A Roadmap for the Development and Validation of ERP Biomarkers in Schizophrenia Research

PubMed Central

Luck, Steven J.; Mathalon, Daniel H.; O'Donnell, Brian F.; Hämäläinen, Matti S.; Spencer, Kevin M.; Javitt, Daniel C.; Uhlhaas, Peter J.

2010-01-01

New efforts to develop treatments for cognitive dysfunction in mental illnesses would benefit enormously from biomarkers that provide sensitive and reliable measures of the neural events underlying cognition. Here we evaluate the promise of event-related potentials (ERPs) as biomarkers of cognitive dysfunction in schizophrenia. We conclude that ERPs have several desirable properties: (a) they provide a direct measure of electrical activity during neurotransmission; (b) their high temporal resolutions makes it possible to measure neural synchrony and oscillations; (c) they are relatively inexpensive and convenient to record; (d) animal models are readily available for several ERP components; (e) decades of research has established the sensitivity and reliability of ERP measures in psychiatric illnesses; and (f) feasibility of large N (>500) multi-site studies has been demonstrated for key measures. Consequently, ERPs may be useful for identifying endophenotypes and defining treatment targets, for evaluating new compounds in animals and in humans, and for identifying individuals who are good candidates for early interventions or for specific treatments. However, several challenges must be overcome before ERPs gain widespread use as biomarkers in schizophrenia research, and we make several recommendations for the research that is necessary to develop and validate ERP-based biomarkers that can have a real impact on treatment development. PMID:21111401

Validation of the Emotiv EPOC® EEG gaming system for measuring research quality auditory ERPs

PubMed Central

Mousikou, Petroula; Mahajan, Yatin; de Lissa, Peter; Thie, Johnson; McArthur, Genevieve

2013-01-01

Background. Auditory event-related potentials (ERPs) have proved useful in investigating the role of auditory processing in cognitive disorders such as developmental dyslexia, specific language impairment (SLI), attention deficit hyperactivity disorder (ADHD), schizophrenia, and autism. However, laboratory recordings of auditory ERPs can be lengthy, uncomfortable, or threatening for some participants – particularly children. Recently, a commercial gaming electroencephalography (EEG) system has been developed that is portable, inexpensive, and easy to set up. In this study we tested if auditory ERPs measured using a gaming EEG system (Emotiv EPOC®, www.emotiv.com) were equivalent to those measured by a widely-used, laboratory-based, research EEG system (Neuroscan). Methods. We simultaneously recorded EEGs with the research and gaming EEG systems, whilst presenting 21 adults with 566 standard (1000 Hz) and 100 deviant (1200 Hz) tones under passive (non-attended) and active (attended) conditions. The onset of each tone was marked in the EEGs using a parallel port pulse (Neuroscan) or a stimulus-generated electrical pulse injected into the O1 and O2 channels (Emotiv EPOC®). These markers were used to calculate research and gaming EEG system late auditory ERPs (P1, N1, P2, N2, and P3 peaks) and the mismatch negativity (MMN) in active and passive listening conditions for each participant. Results. Analyses were restricted to frontal sites as these are most commonly reported in auditory ERP research. Intra-class correlations (ICCs) indicated that the morphology of the research and gaming EEG system late auditory ERP waveforms were similar across all participants, but that the research and gaming EEG system MMN waveforms were only similar for participants with non-noisy MMN waveforms (N = 11 out of 21). Peak amplitude and latency measures revealed no significant differences between the size or the timing of the auditory P1, N1, P2, N2, P3, and MMN peaks. Conclusions. Our findings suggest that the gaming EEG system may prove a valid alternative to laboratory ERP systems for recording reliable late auditory ERPs (P1, N1, P2, N2, and the P3) over the frontal cortices. In the future, the gaming EEG system may also prove useful for measuring less reliable ERPs, such as the MMN, if the reliability of such ERPs can be boosted to the same level as late auditory ERPs. PMID:23638374

Validation of the Emotiv EPOC(®) EEG gaming system for measuring research quality auditory ERPs.

PubMed

Badcock, Nicholas A; Mousikou, Petroula; Mahajan, Yatin; de Lissa, Peter; Thie, Johnson; McArthur, Genevieve

2013-01-01

Background. Auditory event-related potentials (ERPs) have proved useful in investigating the role of auditory processing in cognitive disorders such as developmental dyslexia, specific language impairment (SLI), attention deficit hyperactivity disorder (ADHD), schizophrenia, and autism. However, laboratory recordings of auditory ERPs can be lengthy, uncomfortable, or threatening for some participants - particularly children. Recently, a commercial gaming electroencephalography (EEG) system has been developed that is portable, inexpensive, and easy to set up. In this study we tested if auditory ERPs measured using a gaming EEG system (Emotiv EPOC(®), www.emotiv.com) were equivalent to those measured by a widely-used, laboratory-based, research EEG system (Neuroscan). Methods. We simultaneously recorded EEGs with the research and gaming EEG systems, whilst presenting 21 adults with 566 standard (1000 Hz) and 100 deviant (1200 Hz) tones under passive (non-attended) and active (attended) conditions. The onset of each tone was marked in the EEGs using a parallel port pulse (Neuroscan) or a stimulus-generated electrical pulse injected into the O1 and O2 channels (Emotiv EPOC(®)). These markers were used to calculate research and gaming EEG system late auditory ERPs (P1, N1, P2, N2, and P3 peaks) and the mismatch negativity (MMN) in active and passive listening conditions for each participant. Results. Analyses were restricted to frontal sites as these are most commonly reported in auditory ERP research. Intra-class correlations (ICCs) indicated that the morphology of the research and gaming EEG system late auditory ERP waveforms were similar across all participants, but that the research and gaming EEG system MMN waveforms were only similar for participants with non-noisy MMN waveforms (N = 11 out of 21). Peak amplitude and latency measures revealed no significant differences between the size or the timing of the auditory P1, N1, P2, N2, P3, and MMN peaks. Conclusions. Our findings suggest that the gaming EEG system may prove a valid alternative to laboratory ERP systems for recording reliable late auditory ERPs (P1, N1, P2, N2, and the P3) over the frontal cortices. In the future, the gaming EEG system may also prove useful for measuring less reliable ERPs, such as the MMN, if the reliability of such ERPs can be boosted to the same level as late auditory ERPs.

Alternative approaches for studying humanitarian interventions: propensity score methods to evaluate reintegration packages impact on depression, PTSD, and function impairment among child soldiers in Nepal.

PubMed

Kohrt, B A; Burkey, M; Stuart, E A; Koirala, S

2015-01-01

Ethical, logistical, and funding approaches preclude conducting randomized control trials (RCTs) in some humanitarian crises. A lack of RCTs and other intervention research has contributed to a limited evidence-base for mental health and psychosocial support (MHPS) programs after disasters, war, and disease outbreaks. Propensity score methods (PSMs) are an alternative analysis technique with potential application for evaluating MHPS programs in humanitarian emergencies. PSMs were used to evaluate impacts of education reintegration packages (ERPs) and other (vocational or economic) reintegration packages (ORPs) v. no reintegration programs on mental health of child soldiers. Propensity scores were used to determine weighting of child soldiers in each of the three treatment arms. Multiple linear regression was used to estimate adjusted changes in symptom score severity on culturally validated measures of depression, post-traumatic stress disorder (PTSD), and functional impairment from baseline to 1-year follow-up. Among 258 Nepali child soldiers participating in reintegration programs, 54.7% completed ERP and 22.9% completed ORP. There was a non-significant reduction in depression by 0.59 (95% CI -1.97 to 0.70) for ERP and by 0.60 (95% CI -2.16 to 0.96) for ORP compared with no treatment. There were non-significant increases in PTSD (1.15, 95% CI -1.55 to 3.86) and functional impairment (0.91, 95% CI -0.31 to 2.14) associated with ERP and similar findings for ORP (PTSD: 0.66, 95% CI -2.24 to 3.57; functional impairment (1.05, 95% CI -0.71 to 2.80). In a humanitarian crisis in which a non-randomized intervention assignment protocol was employed, the statistical technique of PSMs addressed differences in covariate distribution between child soldiers who received different integration packages. Our analysis did not demonstrate significant changes in psychosocial outcomes for ERPs and ORPs. We suggest the use of PSMs in evaluating non-randomized interventions in humanitarian crises when non-randomized conditions are not utilized.

A new method to detect event-related potentials based on Pearson's correlation.

PubMed

Giroldini, William; Pederzoli, Luciano; Bilucaglia, Marco; Melloni, Simone; Tressoldi, Patrizio

2016-12-01

Event-related potentials (ERPs) are widely used in brain-computer interface applications and in neuroscience.  Normal EEG activity is rich in background noise, and therefore, in order to detect ERPs, it is usually necessary to take the average from multiple trials to reduce the effects of this noise.  The noise produced by EEG activity itself is not correlated with the ERP waveform and so, by calculating the average, the noise is decreased by a factor inversely proportional to the square root of N , where N is the number of averaged epochs. This is the easiest strategy currently used to detect ERPs, which is based on calculating the average of all ERP's waveform, these waveforms being time- and phase-locked.  In this paper, a new method called GW6 is proposed, which calculates the ERP using a mathematical method based only on Pearson's correlation. The result is a graph with the same time resolution as the classical ERP and which shows only positive peaks representing the increase-in consonance with the stimuli-in EEG signal correlation over all channels.  This new method is also useful for selectively identifying and highlighting some hidden components of the ERP response that are not phase-locked, and that are usually hidden in the standard and simple method based on the averaging of all the epochs.  These hidden components seem to be caused by variations (between each successive stimulus) of the ERP's inherent phase latency period (jitter), although the same stimulus across all EEG channels produces a reasonably constant phase. For this reason, this new method could be very helpful to investigate these hidden components of the ERP response and to develop applications for scientific and medical purposes. Moreover, this new method is more resistant to EEG artifacts than the standard calculations of the average and could be very useful in research and neurology.  The method we are proposing can be directly used in the form of a process written in the well-known Matlab programming language and can be easily and quickly written in any other software language.

The utility of event-related potentials (ERPs) in understanding food-related cognition: A systematic review and recommendations.

PubMed

Carbine, Kaylie A; Rodeback, Rebekah; Modersitzki, Erin; Miner, Marshall; LeCheminant, James D; Larson, Michael J

2018-05-19

Daily dietary decisions have the potential to impact our physical, mental, and emotional health. Event-related potentials (ERPs) can provide insight into cognitive processes, such as attention, working memory, and inhibitory control, that may influence the food-related decisions we make on a daily basis. We conducted a systematic review of the food-related cognition and ERP research in order to summarize the extant literature, identify future research questions, synthesize how food-related ERP components relate to eating habits and appetite, and demonstrate the utility of ERPs in examining food-related cognition. Forty-three articles were systematically extracted. In general, results indicated food cues compared to less palatable foods or neutral cues elicited greater ERP amplitudes reflecting early or late attention allocation (e.g., increased P2, P3, late positive potential amplitudes). Food cues were associated with increased frontocentral P3 and N2 ERP amplitudes compared to neutral or less palatable food cues, suggesting increased recruitment of inhibitory control and conflict monitoring resources. However, there was significant heterogeneity in the literature, as experimental tasks, stimuli, and examined ERP components varied widely across studies, and therefore replication studies are needed. In-depth research is also needed to establish how food-related ERPs differ by BMI groups and relate to real-world eating habits and appetite, in order to establish the ecological validity. Copyright © 2018. Published by Elsevier Ltd.

The Implications of Real Options on ERP-Enabled Adoption

ERIC Educational Resources Information Center

Nwankpa, Joseph K.

2012-01-01

Current research on Enterprise Resource Planning (ERP) systems and real options focuses on valuation and justification issues that manager's face prior to project approval with existing literature attempting to demonstrate that ERP systems as technology positioning investments have option-like characteristics thus making such ERP systems…

Improving Target Detection in Visual Search Through the Augmenting Multi-Sensory Cues

DTIC Science & Technology

2013-01-01

target detection, visual search James Merlo, Joseph E. Mercado , Jan B.F. Van Erp, Peter A. Hancock University of Central Florida 12201 Research Parkway...were controlled by a purpose-created, LabView- based software computer program that synchronised the respective displays and recorded response times and

Event-Related Potentials (ERPs) in Second Language Research: A Brief Introduction to the Technique, a Selected Review, and an Invitation to Reconsider Critical Periods in L2

ERIC Educational Resources Information Center

Steinhauer, Karsten

2014-01-01

This article provides a selective overview of recent event-related brain potential (ERP) studies in L2 morpho-syntax, demonstrating that the ERP evidence supporting the critical period hypothesis (CPH) may be less compelling than previously thought. The article starts with a general introduction to ERP methodology and language-related ERP profiles…

Root Cause Analyses of Nunn-McCurdy Breaches. Volume 2: Excalibur Artillery Projectile and the Navy Enterprise Resource Planning Program, with an Approach to Analyzing Program Complexity and Risk

DTIC Science & Technology

2012-01-01

The mismatch, it was feared, would wreck the processes that the ERP was trying to improve; customers did not have the choice of putting the ERP...program features ahead of attempting a deep dive into the data looking for problems. An initial conceptual framework would allow a decision- maker to

Geochemical database of feed coal and coal combustion products (CCPs) from five power plants in the United States

USGS Publications Warehouse

Affolter, Ronald H.; Groves, Steve; Betterton, William J.; William, Benzel; Conrad, Kelly L.; Swanson, Sharon M.; Ruppert, Leslie F.; Clough, James G.; Belkin, Harvey E.; Kolker, Allan; Hower, James C.

2011-01-01

The principal mission of the U.S. Geological Survey (USGS) Energy Resources Program (ERP) is to (1) understand the processes critical to the formation, accumulation, occurrence, and alteration of geologically based energy resources; (2) conduct scientifically robust assessments of those resources; and (3) study the impacts of energy resource occurrence and (or) their production and use on both the environment and human health. The ERP promotes and supports research resulting in original, geology-based, non-biased energy information products for policy and decision makers, land and resource managers, other Federal and State agencies, the domestic energy industry, foreign governments, non-governmental groups, and academia. Investigations include research on the geology of oil, gas, and coal, and the impacts associated with energy resource occurrence, production, quality, and utilization. The ERP's focus on coal is to support investigations into current issues pertaining to coal production, beneficiation and (or) conversion, and the environmental impact of the coal combustion process and coal combustion products (CCPs). To accomplish these studies, the USGS combines its activities with other organizations to address domestic and international issues that relate to the development and use of energy resources.

Exploring the Effects of Technology Overload on the Outcomes of Enterprise Resource Planning (ERP) Implementation Projects

ERIC Educational Resources Information Center

Kates, Earl B.

2016-01-01

Despite significant investments made by organizations to implement ERP systems and prior research that explored contributing factors of ERP failure, the ERP implementation success rate continues to remain low in practice. Increased technology usage in the workplace coupled with higher dependency on technology to complete project tasks often leads…

Clinch River - Environmental Restoration Program (CR-ERP) pilot study, ambient water toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1997-06-01

Clinch River - Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a pilot study during the week of April 22-29, 1993, prior to initiation of CR-ERP Phase II Sampling and Analysis activities as described in the Statement of Work (SOW) document. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Surface water samples were collected by TVA Field Engineering personnel from Clinch River Mile 9.0 and Poplar Creek Kilometer 1.6 on April 21, 23, and 26. Samples were split and provided to the CR-ERP and TVA toxicology laboratories formore » testing. Exposure of test organisms to these samples resulted in no toxicity (survival, growth, or reproduction) to either species in testing conducted by TVA.« less

Efficacy of cognitive-behavioral therapy for obsessive-compulsive disorder.

PubMed

McKay, Dean; Sookman, Debbie; Neziroglu, Fugen; Wilhelm, Sabine; Stein, Dan J; Kyrios, Michael; Matthews, Keith; Veale, David

2015-05-30

Cognitive-behavioral therapy (CBT), which encompasses exposure with response prevention (ERP) and cognitive therapy (CT), has demonstrated efficacy in the treatment of obsessive-compulsive disorder (OCD). However, the samples studied (reflecting the heterogeneity of OCD), the interventions examined (reflecting the heterogeneity of CBT), and the definitions of treatment response vary considerably across studies. This review examined the meta-analyses conducted on ERP and cognitive therapy (CT) for OCD. Also examined was the available research on long-term outcome associated with ERP and CT. The available research indicates that ERP is the first line evidence based psychotherapeutic treatment for OCD and that concurrent administration of cognitive therapy that targets specific symptom-related difficulties characteristic of OCD may improve tolerance of distress, symptom-related dysfunctional beliefs, adherence to treatment, and reduce drop out. Recommendations are provided for treatment delivery for OCD in general practice and other service delivery settings. The literature suggests that ERP and CT may be delivered in a wide range of clinical settings. Although the data are not extensive, the available research suggests that treatment gains following ERP are durable. Suggestions for future research to refine therapeutic outcome are also considered. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Efficacy of cognitive-behavioral therapy for obsessive-compulsive disorder.

PubMed

McKay, Dean; Sookman, Debbie; Neziroglu, Fugen; Wilhelm, Sabine; Stein, Dan J; Kyrios, Michael; Matthews, Keith; Veale, David

2015-02-28

Cognitive-behavioral therapy (CBT), which encompasses exposure with response prevention (ERP) and cognitive therapy, has demonstrated efficacy in the treatment of obsessive-compulsive disorder (OCD). However, the samples studied (reflecting the heterogeneity of OCD), the interventions examined (reflecting the heterogeneity of CBT), and the definitions of treatment response vary considerably across studies. This review examined the meta-analyses conducted on ERP and cognitive therapy (CT) for OCD. Also examined was the available research on long-term outcome associated with ERP and CT. The available research indicates that ERP is the first line evidence based psychotherapeutic treatment for OCD and that concurrent administration of cognitive therapy that targets specific symptom-related difficulties characteristic of OCD may improve tolerance of distress, symptom-related dysfunctional beliefs, adherence to treatment, and reduce drop out. Recommendations are provided for treatment delivery for OCD in general practice and other service delivery settings. The literature suggests that ERP and CT may be delivered in a wide range of clinical settings. Although the data are not extensive, the available research suggests that treatment gains following ERP are durable. Suggestions for future research to refine therapeutic outcome are also considered. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Family-Based Training Program Improves Brain Function, Cognition, and Behavior in Lower Socioeconomic Status Preschoolers

ERIC Educational Resources Information Center

Pakulak, Eric; Stevens, Courtney; Bell, Theodore A.; Fanning, Jessica; Klein, Scott; Isbell, Elif; Neville, Helen

2013-01-01

Over the course of several years of research, the authors have employed psychophysics, electrophysiological (ERP) and magnetic resonance imaging (MRI) techniques to study the development and neuroplasticity of the human brain. During this time, they observed that different brain systems and related functions display markedly different degrees or…

Choosing MUSE: Validation of a Low-Cost, Portable EEG System for ERP Research

PubMed Central

Krigolson, Olave E.; Williams, Chad C.; Norton, Angela; Hassall, Cameron D.; Colino, Francisco L.

2017-01-01

In recent years there has been an increase in the number of portable low-cost electroencephalographic (EEG) systems available to researchers. However, to date the validation of the use of low-cost EEG systems has focused on continuous recording of EEG data and/or the replication of large system EEG setups reliant on event-markers to afford examination of event-related brain potentials (ERP). Here, we demonstrate that it is possible to conduct ERP research without being reliant on event markers using a portable MUSE EEG system and a single computer. Specifically, we report the results of two experiments using data collected with the MUSE EEG system—one using the well-known visual oddball paradigm and the other using a standard reward-learning task. Our results demonstrate that we could observe and quantify the N200 and P300 ERP components in the visual oddball task and the reward positivity (the mirror opposite component to the feedback-related negativity) in the reward-learning task. Specifically, single sample t-tests of component existence (all p's < 0.05), computation of Bayesian credible intervals, and 95% confidence intervals all statistically verified the existence of the N200, P300, and reward positivity in all analyses. We provide with this research paper an open source website with all the instructions, methods, and software to replicate our findings and to provide researchers with an easy way to use the MUSE EEG system for ERP research. Importantly, our work highlights that with a single computer and a portable EEG system such as the MUSE one can conduct ERP research with ease thus greatly extending the possible use of the ERP methodology to a variety of novel contexts. PMID:28344546

Choosing MUSE: Validation of a Low-Cost, Portable EEG System for ERP Research.

PubMed

Krigolson, Olave E; Williams, Chad C; Norton, Angela; Hassall, Cameron D; Colino, Francisco L

2017-01-01

In recent years there has been an increase in the number of portable low-cost electroencephalographic (EEG) systems available to researchers. However, to date the validation of the use of low-cost EEG systems has focused on continuous recording of EEG data and/or the replication of large system EEG setups reliant on event-markers to afford examination of event-related brain potentials (ERP). Here, we demonstrate that it is possible to conduct ERP research without being reliant on event markers using a portable MUSE EEG system and a single computer. Specifically, we report the results of two experiments using data collected with the MUSE EEG system-one using the well-known visual oddball paradigm and the other using a standard reward-learning task. Our results demonstrate that we could observe and quantify the N200 and P300 ERP components in the visual oddball task and the reward positivity (the mirror opposite component to the feedback-related negativity) in the reward-learning task. Specifically, single sample t -tests of component existence (all p 's < 0.05), computation of Bayesian credible intervals, and 95% confidence intervals all statistically verified the existence of the N200, P300, and reward positivity in all analyses. We provide with this research paper an open source website with all the instructions, methods, and software to replicate our findings and to provide researchers with an easy way to use the MUSE EEG system for ERP research. Importantly, our work highlights that with a single computer and a portable EEG system such as the MUSE one can conduct ERP research with ease thus greatly extending the possible use of the ERP methodology to a variety of novel contexts.

Competitive advantage in the ERP system's value-chain and its influence on future development

NASA Astrophysics Data System (ADS)

Johansson, Björn; Newman, Mike

2010-02-01

Using the resource-based view, we present a set of propositions related to enterprise resource planning (ERP) development, reflections on competitive advantage and the different roles that stakeholders play in the value-chain. This has the goal of building a foundation for future research on ERPs and how stakeholders' desire to achieve competitive advantage influence ERP development, especially when it comes to development of a more standardised or pre-customised ERP system. The propositions also act as a foundation for increasing our knowledge concerning the difficulty in developing improved ERP systems.

Choosing Open Source ERP Systems: What Reasons Are There For Doing So?

NASA Astrophysics Data System (ADS)

Johansson, Björn; Sudzina, Frantisek

Enterprise resource planning (ERP) systems attract a high attention and open source software does it as well. The question is then if, and if so, when do open source ERP systems take off. The paper describes the status of open source ERP systems. Based on literature review of ERP system selection criteria based on Web of Science articles, it discusses reported reasons for choosing open source or proprietary ERP systems. Last but not least, the article presents some conclusions that could act as input for future research. The paper aims at building up a foundation for the basic question: What are the reasons for an organization to adopt open source ERP systems.

Managing the Challenges of Leadership in ERP Implementations: An Exploratory Study of the Leadership Challenges Encountered by Project Managers Involved in ERP Implementation Projects

ERIC Educational Resources Information Center

Wanjagi, James K.

2013-01-01

Increasingly, organizations are conducting more Enterprise Resource Planning (ERP) projects in order to promote organizational efficiencies. Meanwhile, minimal research has been conducted on the leadership challenges faced by project managers during the ERP project implementations and how these challenges are managed. The existing project…

Research in China on event-related potentials in patients with schizophrenia

PubMed Central

Wang, Jijun; Guo, Qian

2012-01-01

Abstract Event-related potentials (ERPs) are objective electrophysiological indicators that can be used to assess cognitive processes in the human brain. Psychiatric researchers in China have applied this method to study schizophrenia since the early 1980s. ERP measures used in the study of schizophrenia include contingent negative variation (CNV), P300, mismatch negativity (MMN), error-related negativity (ERN) and auditory P50 inhibition. This review summarizes the main findings of ERP research in patients with schizophrenia reported by Chinese investigators. PMID:25324605

Is DOD on the Right Path to Financial Auditability?

DTIC Science & Technology

2012-03-22

and DOD decision-making. Moreover, most of the 10 ERPs run the same software applications (i.e. SAP [Systems Applications and Programs] or PeopleSoft...Financial Readiness; GFEBS; DEAMS; Navy ERP 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF...Navy ERP CLASSIFICATION: Unclassified To make every dollar count, the Department of Defense (DOD) must be able to account for every dollar

ERP Reliability Analysis (ERA) Toolbox: An open-source toolbox for analyzing the reliability of event-related brain potentials.

PubMed

Clayson, Peter E; Miller, Gregory A

2017-01-01

Generalizability theory (G theory) provides a flexible, multifaceted approach to estimating score reliability. G theory's approach to estimating score reliability has important advantages over classical test theory that are relevant for research using event-related brain potentials (ERPs). For example, G theory does not require parallel forms (i.e., equal means, variances, and covariances), can handle unbalanced designs, and provides a single reliability estimate for designs with multiple sources of error. This monograph provides a detailed description of the conceptual framework of G theory using examples relevant to ERP researchers, presents the algorithms needed to estimate ERP score reliability, and provides a detailed walkthrough of newly-developed software, the ERP Reliability Analysis (ERA) Toolbox, that calculates score reliability using G theory. The ERA Toolbox is open-source, Matlab software that uses G theory to estimate the contribution of the number of trials retained for averaging, group, and/or event types on ERP score reliability. The toolbox facilitates the rigorous evaluation of psychometric properties of ERP scores recommended elsewhere in this special issue. Copyright © 2016 Elsevier B.V. All rights reserved.

The Event-Related Brain Potential as an Index of Information Processing and Cognitive Activity: A Program of Basic Research.

DTIC Science & Technology

1986-02-20

related brain potential at the Joint EEG Society/ ohp hysioogical Society (ERP) and measures of the electromyogram Meeting. Bristol (England), 1983. and...proving the memory representation of the task ( mem - manipulations of primary-task difficulty attenuated ory data limits). If the P300 amplitude does in

United States Air Force Graduate Student Research Program. Program Technical rept. Volume 3

DTIC Science & Technology

1988-12-01

placing scalp electrodes in a bipolar arrangement. An additional problem we faced in the F4 study was time- loc ::ing the ERP to the eliciting...and Leo Jehl of OEHL for their help with halide and metal analysis that was invalubae to this project. John Barnaby, Will Robinson, Chris Ritter, and...a patient teacher of statistical methods. Dr Eric D. Grassman and Dr Leo Spaccavento explained many technical cardiological points and were generally

Ten years on: a follow-up review of ERP research in attention-deficit/hyperactivity disorder.

PubMed

Johnstone, Stuart J; Barry, Robert J; Clarke, Adam R

2013-04-01

This article reviews the event-related potential (ERP) literature in relation to attention-deficit/hyperactivity disorder (AD/HD) over the years 2002-2012. ERP studies exploring various aspects of brain functioning in children and adolescents with AD/HD are reviewed, with a focus on group effects and interpretations in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions. There has been a distinct shift in research intensity over the past 10 years, with a large increase in ERP studies conducted in the areas of inhibitory control and performance monitoring. Overall, the research has identified a substantial number of ERP correlates of AD/HD. Robust differences from healthy controls have been reported in early orienting, inhibitory control, and error-processing components. These data offer potential to improve our understanding of the specific brain dysfunction(s) which contribute to the disorder. The literature would benefit from a more rigorous approach to clinical group composition and consideration of age effects, as well as increased emphasis on replication and extension studies using exacting participant, task, and analysis parameters. Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Brain-wave measures of workload in advanced cockpits: The transition of technology from laboratory to cockpit simulator, phase 2

NASA Technical Reports Server (NTRS)

Horst, Richard L.; Mahaffey, David L.; Munson, Robert C.

1989-01-01

The present Phase 2 small business innovation research study was designed to address issues related to scalp-recorded event-related potential (ERP) indices of mental workload and to transition this technology from the laboratory to cockpit simulator environments for use as a systems engineering tool. The project involved five main tasks: (1) Two laboratory studies confirmed the generality of the ERP indices of workload obtained in the Phase 1 study and revealed two additional ERP components related to workload. (2) A task analysis' of flight scenarios and pilot tasks in the Advanced Concepts Flight Simulator (ACFS) defined cockpit events (i.e., displays, messages, alarms) that would be expected to elicit ERPs related to workload. (3) Software was developed to support ERP data analysis. An existing ARD-proprietary package of ERP data analysis routines was upgraded, new graphics routines were developed to enhance interactive data analysis, and routines were developed to compare alternative single-trial analysis techniques using simulated ERP data. (4) Working in conjunction with NASA Langley research scientists and simulator engineers, preparations were made for an ACFS validation study of ERP measures of workload. (5) A design specification was developed for a general purpose, computerized, workload assessment system that can function in simulators such as the ACFS.

Design Patterns Application in the ERP Systems Improvements

NASA Astrophysics Data System (ADS)

Jovičić, Bojan; Vlajić, Siniša

Design patterns application have long been present in software engineering. The same is true for ERP systems in business software. Is it possible that ERP systems do not have a good maintenance score? We have found out that there is room for maintenance improvement and that it is possible to improve ERP systems using design patterns. We have conducted comparative analysis of ease of maintenance of the ERP systems. The results show that the average score for our questions is 64%, with most answers for ERP systems like SAP, Oracle EBS, Dynamics AX. We found that 59% of ERP system developer users are not familiar with design patterns. Based on this research, we have chosen Dynamics AX as the ERP system for examination of design patterns improvement possibilities. We used software metrics to measure improvement possibility. We found that we could increase the Conditional Complexity score 17-fold by introducing design patterns.

Assessing the internal consistency of the event-related potential: An example analysis.

PubMed

Thigpen, Nina N; Kappenman, Emily S; Keil, Andreas

2017-01-01

ERPs are widely and increasingly used to address questions in psychophysiological research. As discussed in this special issue, a renewed focus on questions of reliability and stability marks the need for intuitive, quantitative descriptors that allow researchers to communicate the robustness of ERP measures used in a given study. This report argues that well-established indices of internal consistency and effect size meet this need and can be easily extracted from most ERP datasets, as demonstrated with example analyses using a representative dataset from a feature-based visual selective attention task. We demonstrate how to measure the internal consistency of three aspects commonly considered in ERP studies: voltage measurements for specific time ranges at selected sensors, voltage dynamics across all time points of the ERP waveform, and the distribution of voltages across the scalp. We illustrate methods for quantifying the robustness of experimental condition differences, by calculating effect size for different indices derived from the ERP. The number of trials contributing to the ERP waveform was manipulated to examine the relationship between signal-to-noise ratio (SNR), internal consistency, and effect size. In the present example dataset, satisfactory consistency (Cronbach's alpha > 0.7) of individual voltage measurements was reached at lower trial counts than were required to reach satisfactory effect sizes for differences between experimental conditions. Comparing different metrics of robustness, we conclude that the internal consistency and effect size of ERP findings greatly depend on the quantification strategy, the comparisons and analyses performed, and the SNR. © 2016 Society for Psychophysiological Research.

Navy Enterprise Resource Planning System Does Not Comply With the Standard Financial Information Structure and U.S. Government Standard General Ledger

DTIC Science & Technology

2012-02-13

Operations DCMO Deputy Chief Management Officer DDRS Defense Departmental Reporting System DFAS Defense Finance and Accounting Service ERP Enterprise...for your review and comment. The Navy approved deployment of the Navy Enterprise Resource Planning ( ERP ) System without ensuring it complied with the...Comments from the Deputy Assistant Secretary of the Navy (Financial Management and Comptroller, Office of Financial Operations) and the Navy ERP Program

Towards a holistic assessment of the user experience with hybrid BCIs.

PubMed

Lorenz, Romy; Pascual, Javier; Blankertz, Benjamin; Vidaurre, Carmen

2014-06-01

In recent years, brain-computer interfaces (BCIs) have become mature enough to immensely benefit from the expertise and tools established in the field of human-computer interaction (HCI). One of the core objectives in HCI research is the design of systems that provide a pleasurable user experience (UX). While the majority of BCI studies exclusively evaluate common efficiency measures such as classification accuracy and speed, single research groups have begun to look at further usability aspects such as ease of use, workload and learnability. However, these evaluation metrics only cover pragmatic aspects of UX while still not considering the hedonic quality of UX. In order to gain a holistic perspective on UX, hedonic quality aspects such as motivation and frustration were also taken into account for our evaluation of three BCI-driven interfaces, which were proposed to be used as a two-stage neuroprosthetic control within the EU project MUNDUS. At the first stage, one of six possible actions was selected and either confirmed or cancelled at the second stage. For the experiment, a solely event-related-potential-based interface (ERP-ERP) and two hybrid solutions were tested that were controlled by ERP and motor imagery (MI)--resulting in the two possible combinations: ERP selection/MI confirmation (ERP-MI) or MI selection/ERP confirmation (MI-ERP). Behavioural, subjective and encephalographic (EEG) data of 12 healthy subjects were collected during an online experiment with the three graphical user interfaces (GUIs). Results showed a significantly greater pragmatic quality (in terms of accuracy, efficiency, workload, use quality and learnability) for the ERP-ERP and ERP-MI GUIs in contrast to the MI-ERP GUI. Consequently, the MI-ERP GUI is least suited for use as a neuroprosthetic control. With respect to the comparison of the ERP-ERP and ERP-MI GUIs, no significant differences in pragmatic and hedonic quality of UX were found. Since throughout better results were obtained for the conventional approach and it was most preferred by the subjects, the ERP-ERP GUI seems more suitable for its deployment in actual end-users. Nevertheless, for individuals with stable MI patterns, the hybrid interface can be provided as an additional option of choice within the MUNDUS framework. Although the paramount goal in BCI research still remains the improvement of classification accuracy and communication speed, it is of significance to note that it is equally important for end-users to keep up their motivation and prevent frustration. By including pragmatic as well as hedonic quality aspects, this study is the first effort to gain a holistic perspective of the UX while interacting with BCI-driven assistive technology aimed at actual end-users. The broad-scale methodology provided valuable insights into the underlying dynamics causing the users' experience to differ across the GUIs. The results will be used to refine a BCI-driven neuroprosthesis and test it with end-users.

Towards a holistic assessment of the user experience with hybrid BCIs

NASA Astrophysics Data System (ADS)

Lorenz, Romy; Pascual, Javier; Blankertz, Benjamin; Vidaurre, Carmen

2014-06-01

Objective. In recent years, brain-computer interfaces (BCIs) have become mature enough to immensely benefit from the expertise and tools established in the field of human-computer interaction (HCI). One of the core objectives in HCI research is the design of systems that provide a pleasurable user experience (UX). While the majority of BCI studies exclusively evaluate common efficiency measures such as classification accuracy and speed, single research groups have begun to look at further usability aspects such as ease of use, workload and learnability. However, these evaluation metrics only cover pragmatic aspects of UX while still not considering the hedonic quality of UX. In order to gain a holistic perspective on UX, hedonic quality aspects such as motivation and frustration were also taken into account for our evaluation of three BCI-driven interfaces, which were proposed to be used as a two-stage neuroprosthetic control within the EU project MUNDUS. Approach. At the first stage, one of six possible actions was selected and either confirmed or cancelled at the second stage. For the experiment, a solely event-related-potential-based interface (ERP-ERP) and two hybrid solutions were tested that were controlled by ERP and motor imagery (MI)—resulting in the two possible combinations: ERP selection/MI confirmation (ERP-MI) or MI selection/ERP confirmation (MI-ERP). Behavioural, subjective and encephalographic (EEG) data of 12 healthy subjects were collected during an online experiment with the three graphical user interfaces (GUIs). Main results. Results showed a significantly greater pragmatic quality (in terms of accuracy, efficiency, workload, use quality and learnability) for the ERP-ERP and ERP-MI GUIs in contrast to the MI-ERP GUI. Consequently, the MI-ERP GUI is least suited for use as a neuroprosthetic control. With respect to the comparison of the ERP-ERP and ERP-MI GUIs, no significant differences in pragmatic and hedonic quality of UX were found. Since throughout better results were obtained for the conventional approach and it was most preferred by the subjects, the ERP-ERP GUI seems more suitable for its deployment in actual end-users. Nevertheless, for individuals with stable MI patterns, the hybrid interface can be provided as an additional option of choice within the MUNDUS framework. Significance. Although the paramount goal in BCI research still remains the improvement of classification accuracy and communication speed, it is of significance to note that it is equally important for end-users to keep up their motivation and prevent frustration. By including pragmatic as well as hedonic quality aspects, this study is the first effort to gain a holistic perspective of the UX while interacting with BCI-driven assistive technology aimed at actual end-users. The broad-scale methodology provided valuable insights into the underlying dynamics causing the users’ experience to differ across the GUIs. The results will be used to refine a BCI-driven neuroprosthesis and test it with end-users.

Static renewal tests using Pimephales promelas (fathead minnows) and Ceriodaphnia dubia (daphnids). Clinch River-Environmental Restoration Program (CR-ERP) pilot study, ambient water toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1993-12-31

Clinch River-Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a pilot study during the week of April 22--29, 1993, prior to initiation of CR-ERP Phase 2 Sampling and Analysis activities. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Surface water samples were collected by TVA Field Engineering personnel from Clinch River Mile 9.0 and Poplar Creek Kilometer 1.6 on April 21, 23, and 26. Samples were split and provided to the CR-ERP and TVA toxicology laboratories for testing. Exposure of test organisms to these samples resulted in nomore » toxicity (survival, growth, or reproduction) to either species in testing conducted by TVA. Attachments to this report include: Chain of custody forms -- originals; Toxicity test bench sheets and statistical analyses; Reference toxicant test information; and Personnel training documentation.« less

Clinch River - Environmental Restoration Program (CR-ERP) study, ambient water toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russell, C.L.

1997-06-01

Clinch River - Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a study during the week of July 22-29, 1993, as described in the Statement of Work (SOW) document. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Surface water samples were collected by TVA Field Engineering personnel from Clinch River Mile 19.0 and Mile 22.0 on July 21, 23, and 26. Samples were split and provided to the CR-ERP and TVA toxicology laboratories for testing. Exposure of test organisms to these samples resulted in no toxicity (survival, growth,more » or reproduction) to either species in testing conducted by TVA.« less

Usability evaluation of in-housed developed ERP system

NASA Astrophysics Data System (ADS)

Faisal, Chaudhry Muhammad Nadeem; Shakeel Faridi, Muhammad; Javed, Zahid

2011-10-01

Enterprise Resource Planning systems are the combination of different business IS (Information System) applications that are designed according to the organization requirements. Generally ERP systems are suffering from complex user interface issues. Recent research shows that there is a need for improvement concerning, the user interface from their perspectives. In order to design the software applications that are easy to use, memorize and apply to new problems, we must know the users philosophy and something about learning, reminiscence and problems solving. The Usability engineering is the only way to study the deeds of users while interacting with ERP (Enterprise Resource & Planning). This paper will focus on the users' experiences view of financial module in ERP system. The HCI research method, explicitly survey questionnaire method was adopted to gather users understanding in order to evaluate the selected modules for in-housed ERP system. The study involved group of users from two industries, the results can not be generalized as a whole. The study was first time successfully applied Usability evaluation on in-housed ERP in local industry (Masood Textile Mills, Interloop Ltd) in Pakistan. The results may hopefully opened-up an area of research and methodology that could provide considerable further benefits to Industry in developments of Industrial information systems.

[Progress on neuropsychology and event-related potentials in patients with brain trauma].

PubMed

Dong, Ri-xia; Cai, Wei-xiong; Tang, Tao; Huang, Fu-yin

2010-02-01

With the development of information technology, as one of the research frontiers in neurophysiology, event-related potentials (ERP) is concerned increasingly by international scholars, which provides a feasible and objective method for exploring cognitive function. There are many advances in neuropsychology due to new assessment tool for the last years. The basic theories in the field of ERP and neuropsychology were reviewed in this article. The research and development in evaluating cognitive function of patients with syndrome after brain trauma were focused in this review, and the perspectives for the future research of ERP was also explored.

Improving Training in Enterprise Resource Planning Systems Implementation through Communities of Practice

ERIC Educational Resources Information Center

Kerr, Don; Burgess, Kevin J.; Houghton, Luke; Murray, Peter A.

2012-01-01

The Enterprise Resource Planning (ERP) literature suggests that effective training is one of the key reasons for success in ERP implementations. However, limited research has been conducted on what constitutes effective training in an ERP environment. A case study approach was used to explore the effectiveness of traditional training and to…

Large-scale implementation of enhanced recovery programs after surgery. A francophone experience.

PubMed

Veziant, J; Raspado, O; Entremont, A; Joris, J; Pereira, B; Slim, K

2017-06-01

Enhanced recovery after surgery program (ERP) has now surpassed the stage of clinical research in certain specialties and currently poses the problematic of large-scale implementation. The goal of this study was to report the experience during the first year of implementation in three French-speaking countries. This is a prospective study in which 67 healthcare centers, all registered in the Grace-Audit databank, participated. Included were patients undergoing colorectal (CRS), bariatric (BS) and orthopedic hip and knee surgery (OS), performed within an ERP. The main endpoints were duration of hospital stay, postoperative morbidity, the degree of compliance with the elements of the ERP, the relation between the extent of application of the elements and postoperative hospital stay, and finally the completeness of data inclusions in the databank. A total of 1904 patients were included in the Grace-Audit databank between January 1, 2015 and January 31, 2016, undergoing CRS (n=490), BS (n=431), and OS (n=983). The mean implementation rate was 83.7±10.0% for CRS, 75.0±23.7% for BS, and 83.5±14.9% for OS. The duration of hospital stay was 6.5 days for CRS, 2.6 days for BS and 3.4 days for OS. Overall postoperative morbidity (onset of postoperative undesirable event), surgical morbidity (superficial or deep organ space surgical site complications such as bleeding, infection or defective healing) and readmission rates were 20.6%, 7.5%, and 5.7% for CRS; 2.5%, 1.4%, and 1.6% for BS and 2.9%, 0.2%, and 2% for OS, respectively. A statistically significant relationship was found between the degree of compliance of the elements of ERP and the duration of hospital stay for CRS and BS; hospital stay was reduced when at least 15 of the 22 elements of the program were applied (P<0.001). The patients included in the Grace-Audit databank represented less than 20% of the patients undergoing operation in the same establishments during the study period for all three specialties. This study shows that large-scale ERPs are feasible and safe in French-speaking countries. Nonetheless, although encouraging, these preliminary results highlight that implementation must be improved in specialties such as bariatric surgery and that more complete data collection is needed. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Guidance: RCRAInfo Data Appendix for the 2003 Enforcement Response Policy

EPA Pesticide Factsheets

This appendix is designed to translate the information contained in the December 2003 Enforcement Response Policy (ERP) into specific RCRAInfo data terms to ensure data is entered into the system correctly in order to accurately reflect the enforcement program as specified in the attached ERP.

Tracking the dynamics of the social brain: ERP approaches for social cognitive and affective neuroscience

PubMed Central

Amodio, David M.; Ito, Tiffany A.

2014-01-01

Event-related potential (ERP) approaches to social cognitive and affective neuroscience (SCAN) are not as widely used as other neuroimaging techniques, yet they offer several unique advantages. In particular, the high temporal resolution of ERP measures of neural activity make them ideally suited for studying the dynamic interplay of rapidly unfolding cognitive and affective processes. In this article, we highlight the utility of ERP methods for scientists investigating questions of SCAN. We begin with a brief description of the physiological basis of ERPs and discussion of methodological practices. We then discuss how ERPs may be used to address a range of questions concerning social perception, social cognition, attitudes, affect and self-regulation, with examples of research that has used the ERP approach to contribute important theoretical advances in these areas. Whether used alone or in combination with other techniques, the ERP is an indispensable part of the social and affective neuroscientist’s methodological toolkit. PMID:24319116

Tracking the dynamics of the social brain: ERP approaches for social cognitive and affective neuroscience.

PubMed

Amodio, David M; Bartholow, Bruce D; Ito, Tiffany A

2014-03-01

Event-related potential (ERP) approaches to social cognitive and affective neuroscience (SCAN) are not as widely used as other neuroimaging techniques, yet they offer several unique advantages. In particular, the high temporal resolution of ERP measures of neural activity make them ideally suited for studying the dynamic interplay of rapidly unfolding cognitive and affective processes. In this article, we highlight the utility of ERP methods for scientists investigating questions of SCAN. We begin with a brief description of the physiological basis of ERPs and discussion of methodological practices. We then discuss how ERPs may be used to address a range of questions concerning social perception, social cognition, attitudes, affect and self-regulation, with examples of research that has used the ERP approach to contribute important theoretical advances in these areas. Whether used alone or in combination with other techniques, the ERP is an indispensable part of the social and affective neuroscientist's methodological toolkit.

Auditory Evoked Potentials as a Function of Sleep Deprivation and Recovery Sleep

DTIC Science & Technology

1985-09-29

present research: They relate to the effects of: a) 48-hours of sleep deprivation on endogenous event related potentials (ERPs); b) circadian rhythms on...the study were: decreases in amplitude for N2, P3 and N2P3 across the reprivation period; a circadian rhythm was apparent for both ERP recordings and...of cortical evoked response potentials (ERPs)? 2) How do circadian rhythms affect ERPS under conditions of sleep deprivation? 3) How do different

The roles of users personal characteristics and organisational support in the attitude towards using ERP systems in a Spanish public hospital.

PubMed

Escobar-Rodriguez, Tomas; Bartual-Sopena, Lourdes

Enterprise resources planning (ERP) systems enable central and integrative control over all processes throughout an organisation by ensuring one data entry point and the use of a common database. T his paper analyses the attitude of healthcare personnel towards the use of an ERP system in a Spanish public hospital, identifying influencing factors. This research is based on a regression analysis of latent variables using the optimisation technique of partial least squares. We propose a research model including possible relationships among different constructs using the technology acceptance model. Our results show that the personal characteristics of potential users are key factors in explaining attitude towards using ERP systems.

Private and Public Sector Enterprise Resource Planning System Post-Implementation Practices: A Comparative Mixed Method Investigation

ERIC Educational Resources Information Center

Bachman, Charles A.

2010-01-01

While private sector organizations have implemented enterprise resource planning (ERP) systems since the mid 1990s, ERP implementations within the public sector lagged by several years. This research conducted a mixed method, comparative assessment of post "go-live" ERP implementations between public and private sector organization. Based on a…

Effects of people-centred factors on enterprise resource planning implementation project success: empirical evidence from Sri Lanka

NASA Astrophysics Data System (ADS)

Wickramasinghe, Vathsala; Gunawardena, Vathsala

2010-08-01

Extant literature suggests people-centred factors as one of the major areas influencing enterprise resource planning (ERP) implementation project success. Yet, to date, few empirical studies attempted to validate the link between people-centred factors and ERP implementation project success. The purpose of this study is to empirically identify people-centred factors that are critical to ERP implementation projects in Sri Lanka. The study develops and empirically validates a framework for people-centred factors that influence the success of ERP implementation projects. Survey research methodology was used and collected data from 74 ERP implementation projects in Sri Lanka. The people-centred factors of 'project team competence', 'rewards' and 'communication and change' were found to predict significantly the ERP implementation project success.

ERP implementation in hospitals: a case study.

PubMed

Agarwal, Divya; Garg, Poonam

2012-01-01

In a competitive healthcare sector, hospitals have to focus on their processes in order to deliver high-quality care while at the same time reducing costs. Many hospitals have decided to adopt one or another Enterprise Resource Planning (ERP) system to improve their businesses, but implementing an ERP system can be a demanding endeavour. The systems are so difficult to implement that some are successful; many have failed, causing multimillion dollar losses. The challenge of ERP solutions lie in implementation because they are complex, time consuming and expensive too. This paper describes the various process workflows and phases of ERP implementation at Fortis Hospital Cunningham Road, Bangalore, India. This knowledge will provide valuable insights for the researchers and practitioners to understand the different process workflows and to make informed decisions when implementing ERP in any hospital.

Developmental coordination disorder in children - experimental work and data annotation.

PubMed

Vareka, Lukáš; Bruha, Petr; Moucek, Roman; Mautner, Pavel; Cepicka, Ladislav; Holecková, Irena

2017-04-01

Developmental coordination disorder (DCD) is described as a motor skill disorder characterized by a marked impairment in the development of motor coordination abilities that significantly interferes with performance of daily activities and/or academic achievement. Since some electrophysiological studies suggest differences between children with/without motor development problems, we prepared an experimental protocol and performed electrophysiological experiments with the aim of making a step toward a possible diagnosis of this disorder using the event-related potentials (ERP) technique. The second aim is to properly annotate the obtained raw data with relevant metadata and promote their long-term sustainability. The data from 32 school children (16 with possible DCD and 16 in the control group) were collected. Each dataset contains raw electroencephalography (EEG) data in the BrainVision format and provides sufficient metadata (such as age, gender, results of the motor test, and hearing thresholds) to allow other researchers to perform analysis. For each experiment, the percentage of ERP trials damaged by blinking artifacts was estimated. Furthermore, ERP trials were averaged across different participants and conditions, and the resulting plots are included in the manuscript. This should help researchers to estimate the usability of individual datasets for analysis. The aim of the whole project is to find out if it is possible to make any conclusions about DCD from EEG data obtained. For the purpose of further analysis, the data were collected and annotated respecting the current outcomes of the International Neuroinformatics Coordinating Facility Program on Standards for Data Sharing, the Task Force on Electrophysiology, and the group developing the Ontology for Experimental Neurophysiology. The data with metadata are stored in the EEG/ERP Portal. © The Authors 2017. Published by Oxford University Press.

Assessing the internal consistency of the event-related potential: An example analysis

PubMed Central

Thigpen, Nina; Kappenman, Emily; Keil, Andreas

2017-01-01

Event-related potentials (ERPs) are widely and increasingly used to address questions in Psychophysiological research. As discussed in this special issue, a renewed focus on questions of reliability and stability marks the need for intuitive, quantitative descriptors that allow researchers to communicate the robustness of ERP measures used in a given study. This report argues that well-established indices of internal consistency and effect size meet this need and can be easily extracted from most ERP data sets, as demonstrated with example analyses using a representative data set from a feature-based visual selective attention task. We demonstrate how to measure the internal consistency of three aspects commonly considered in ERP studies: Voltage measurements for specific time ranges at selected sensors, voltage dynamics across all time points of the ERP waveform, and the distribution of voltages across the scalp. We illustrate methods for quantifying the robustness of experimental condition differences, by calculating effect size for different indices derived from the ERP. The number of trials contributing to the ERP waveform was manipulated to examine the relationship between signal-to-noise ratio, internal consistency, and effect size. In the present example data set, satisfactory consistency (Cronbach’s alpha > 0.7) of individual voltage measurements was reached at lower trial counts than were required to reach satisfactory effect sizes for differences between experimental conditions. Comparing different metrics of robustness, we conclude that the SNR, internal consistency, and effect size of ERP findings greatly depend on the quantification strategy, the comparisons and analyses performed, and the signal-to-noise ratio. PMID:28000264

Total Cost of Ownership, System Acceptance and Perceived Success of Enterprise Resource Planning Software: Simulating a Dynamic Feedback Perspective of ERP in the Higher Education Environment

ERIC Educational Resources Information Center

Fryling, Meg

2010-01-01

Enterprise Research Planning (ERP) software is advertised as the product that will "run the enterprise", improving data access and accuracy as well as enhancing business process efficiency. Unfortunately, organizations often make implementation decisions with little consideration for the maintenance phase of an ERP, resulting in significant…

The U.S.Geological Survey Energy Resources Program

USGS Publications Warehouse

,

2010-01-01

Energy resources are an essential component of modern society. Adequate, reliable, and affordable energy supplies obtained using environmentally sustainable practices underpin economic prosperity, environmental quality and human health, and political stability. National and global demands for all forms of energy are forecast to increase significantly over the next several decades. Throughout its history, our Nation has faced important, often controversial, decisions regarding the competing uses of public lands, the supply of energy to sustain development and enable growth, and environmental stewardship. The U.S. Geological Survey (USGS) Energy Resources Program (ERP) provides information to address these challenges by supporting scientific investigations of energy resources, such as research on the geology, geochemistry, and geophysics of oil, gas, coal, heavy oil and natural bitumen, oil shale, uranium, and geothermal resources, emerging resources such as gas hydrates, and research on the effects associated with energy resource occurrence, production, and (or) utilization. The results from these investigations provide impartial, robust scientific information about energy resources and support the U.S. Department of the Interior's (DOI's) mission of protecting and responsibly managing the Nation's natural resources. Primary consumers of ERP information and products include the DOI land- and resource-management Bureaus; other Federal, State, and local agencies; the U.S. Congress and the Administration; nongovernmental organizations; the energy industry; academia; international organizations; and the general public.

Making sense of all the conflict: a theoretical review and critique of conflict-related ERPs.

PubMed

Larson, Michael J; Clayson, Peter E; Clawson, Ann

2014-09-01

Cognitive control theory suggests that goal-directed behavior is governed by a dynamic interplay between areas of the prefrontal cortex. Critical to cognitive control is the detection and resolution of competing stimulus or response representations (i.e., conflict). Event-related potential (ERP) research provides a window into the nature and precise temporal sequence of conflict monitoring. We critically review the research on conflict-related ERPs, including the error-related negativity (ERN), Flanker N2, Stroop N450 and conflict slow potential (conflict SP or negative slow wave [NSW]), and provide an analysis of how these ERPs inform conflict monitoring theory. Overall, there is considerable evidence that amplitude of the ERN is sensitive to the degree of response conflict, consistent with a role in conflict monitoring. It remains unclear, however, to what degree contextual, individual, affective, and motivational factors influence ERN amplitudes and how ERN amplitudes are related to regulative changes in behavior. The Flanker N2, Stroop N450, and conflict SP ERPs represent distinct conflict-monitoring processes that reflect conflict detection (N2, N450) and conflict adjustment or resolution processes (N2, conflict SP). The investigation of conflict adaptation effects (i.e., sequence or sequential trial effects) shows that the N2 and conflict SP reflect post-conflict adjustments in cognitive control, but the N450 generally does not. Conflict-related ERP research provides a promising avenue for understanding the effects of individual differences on cognitive control processes in healthy, neurologic and psychiatric populations. Comparisons between the major conflict-related ERPs and suggestions for future studies to clarify the nature of conflict-related neural processes are provided. Copyright © 2014 Elsevier B.V. All rights reserved.

Mindfulness-based exposure and response prevention for obsessive compulsive disorder: study protocol for a pilot randomised controlled trial.

PubMed

Strauss, Clara; Rosten, Claire; Hayward, Mark; Lea, Laura; Forrester, Elizabeth; Jones, Anna-Marie

2015-04-16

Obsessive Compulsive Disorder (OCD) is a distressing and debilitating condition affecting 1-2% of the population. Exposure and response prevention (ERP) is a behaviour therapy for OCD with the strongest evidence for effectiveness of any psychological therapy for the condition. Even so, only about half of people offered ERP show recovery after the therapy. An important reason for ERP failure is that about 25% of people drop out early, and even for those who continue with the therapy, many do not regularly engage in ERP tasks, an essential element of ERP. A mindfulness-based approach has the potential to reduce drop-out from ERP and to improve ERP task engagement with an emphasis on accepting difficult thoughts, feelings and bodily sessions and on becoming more aware of urges, rather than automatically acting on them. This is a pilot randomised controlled trial of mindfulness-based ERP (MB-ERP) with the aim of establishing parameters for a definitive trial. Forty participants diagnosed with OCD will be allocated at random to a 10-session ERP group or to a 10-session MB-ERP group. Primary outcomes are OCD symptom severity and therapy engagement. Secondary outcomes are depressive symptom severity, wellbeing and obsessive-compulsive beliefs. A semi-structured interview with participants will guide understanding of change processes. Findings from this pilot study will inform future research in this area, and if effect sizes on primary outcomes are in favour of MB-ERP in comparison to ERP, funding for a definitive trial will be sought. Current Controlled Trials registration number ISRCTN52684820. Registered on 30 January 2014.

Examining Success Factors Related to ERP Implementations in Higher Education Shared Services Projects

ERIC Educational Resources Information Center

Stoyanoff, Dawn Galadriel Pfeiffer

2012-01-01

This study examined the enterprise resource planning (ERP) implementations that utilized a shared services model in higher education. The purpose of this research was to examine the critical success factors which were perceived to contribute to project success. This research employed a quantitative non-experimental correlational design and the…

Implementing enhanced recovery pathways: a literature review with realist synthesis.

PubMed

Coxon, Astrid; Nielsen, Karina; Cross, Jane; Fox, Chris

2017-10-01

Enhanced Recovery Pathways (ERPs) are an increasingly popular, evidenced-based approach to surgery, designed to improve patient outcomes and reduce costs. Despite evidence demonstrating the benefits of these pathways, implementation and adherence have been inconsistent. Using realist synthesis, this review explored the current literature surrounding the implementation of ERPs in the UK. Knowledge consolidation between authors and consulting with field experts helped to guide the search strategy. Relevant medical and social science databases were searched from 2000 to 2016, as well as a general web search. A total of 17 papers were identified, including original research, reviews, case studies and guideline documents. Full texts were analysed, cross-examined, and data extracted and synthesised. Several implementation strategies were identified, including the contexts in which these operated, the subsequent mechanisms of action that were triggered, and the outcome patterns they produced. Context-Mechanism-Outcome (CMO) configurations were generated, tested, and refined. These were grouped to develop two programme theories concerning ERP implementation, one related to the strategy of consulting with staff, the other with appointing a change agent to coordinate and drive the implementation process. These theories highlight instances in which implementation could be improved. Current literature in ERP research is primarily focussed on measuring patient outcomes and cost effectiveness, and as a result, important detail regarding the implementation process is often not reported or described robustly. This review not only provides recommendations for future improvements in ERP implementation, but also highlights specific areas of focus for furthering ERP implementation research.

"E-Book Flood" for Changing EFL Learners' Reading Attitudes

ERIC Educational Resources Information Center

Lin, Chih-Cheng

2010-01-01

This paper was intended to investigate the effects of using e-books (or texts with multimedia support) in an ERP (extensive reading program) on EFL (English as a foreign language) learners' attitudes toward reading in English. In a junior high school in northern Taiwan, 109 students from 3 intact classes were recruited in the 10-week ERP of…

Anodonta imbecillis QA Test 2, Clinch River - Environmental Restoration Program (CR-ERP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1997-06-01

Toxicity testing of split whole sediment samples using juvenile freshwater mussels (Atiodonta imbecillis) was conducted by TVA to provide a quality assurance mechanism for test organism quality and overall performance of the test being conducted by CR-ERP personnel as part of the CR-ERP biomonitoring study of Clinch River sediments. Testing of sediment samples collected August 14 from Poplar Creek Miles 6.0 and 4.3 was conducted from August 24-September 2, 1993. Results from this test showed no toxicity (survival effects) to fresh--water mussels during a 9-day exposure to the sediments.

Anodonta imbecillis QA Test 3, Clinch River - Environmental Restoration Program (CR-ERP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1997-06-01

Toxicity testing of split whole sediment samples using juvenile freshwater mussels (Anodonta imbecillis) was conducted by TVA to provide a quality assurance mechanism for test organism quality and overall performance of the test being conducted by CR-ERP personnel as part of the CR-ERP biomonitoring study of Clinch River sediments. Testing of sediment samples collected May 5 from Poplar Creek Miles 6.0 and 2.9 was conducted from May 10-19, 1994. Results from this test showed no toxicity (survival effects) to fresh-water mussels during a 9-day exposure to the sediments.

ERP profiles for face and word recognition are based on their status in semantic memory not their stimulus category.

PubMed

Nie, Aiqing; Griffin, Michael; Keinath, Alexander; Walsh, Matthew; Dittmann, Andrea; Reder, Lynne

2014-04-04

Previous research has suggested that faces and words are processed and remembered differently as reflected by different ERP patterns for the two types of stimuli. Specifically, face stimuli produced greater late positive deflections for old items in anterior compared to posterior regions, while word stimuli produced greater late positive deflections in posterior compared to anterior regions. Given that words have existing representations in subjects׳ long-term memories (LTM) and that face stimuli used in prior experiments were of unknown individuals, we conducted an ERP study that crossed face and letter stimuli with the presence or absence of a prior (stable or existing) memory representation. During encoding, subjects judged whether stimuli were known (famous face or real word) or not known (unknown person or pseudo-word). A surprise recognition memory test required subjects to distinguish between stimuli that appeared during the encoding phase and stimuli that did not. ERP results were consistent with previous research when comparing unknown faces and words; however, the late ERP pattern for famous faces was more similar to that for words than for unknown faces. This suggests that the critical ERP difference is mediated by whether there is a prior representation in LTM, and not whether the stimulus involves letters or faces. Published by Elsevier B.V.

Investigation of the mediating effects of IT governance-value delivery on service quality and ERP performance

NASA Astrophysics Data System (ADS)

Tsai, Wen-Hsien; Chou, Yu-Wei; Leu, Jun-Der; Chao Chen, Der; Tsaur, Tsen-Shu

2015-02-01

This study aimed to explore the mediating effects of IT governance (ITG)-value delivery in the relationships among the quality of vendor service, the quality of consultant services, ITG-value delivery and enterprise resource planning (ERP) performance. The sampling of this research was acquired from a questionnaire survey concerning ERP implementations in Taiwan. In this survey, 4366 questionnaires were sent to manufacturing and service companies listed in the TOP 5000: The Largest Corporations in Taiwan 2009. The results showed that an ERP system will exhibit a decreased error rate and improved performance if ERP system vendors and consultants provide good service quality. The results also demonstrated that significant relationships exist among the quality of vendor service, the quality of consultant services and value delivery. The contribution of this article is twofold. First, it found that value delivery provides an effective measure of ERP performance under an ITG framework. Second, it provides evidence of the partial mediating effects of value delivery between service quality and ERP performance. In other words, if enterprises want to improve ERP performance, they need to consider factors such as value delivery and the quality of a vendor/consultant's service.

Validation of the Emotiv EPOC EEG system for research quality auditory event-related potentials in children

PubMed Central

Preece, Kathryn A.; de Wit, Bianca; Glenn, Katharine; Fieder, Nora; Thie, Johnson; McArthur, Genevieve

2015-01-01

Background. Previous work has demonstrated that a commercial gaming electroencephalography (EEG) system, Emotiv EPOC, can be adjusted to provide valid auditory event-related potentials (ERPs) in adults that are comparable to ERPs recorded by a research-grade EEG system, Neuroscan. The aim of the current study was to determine if the same was true for children. Method. An adapted Emotiv EPOC system and Neuroscan system were used to make simultaneous EEG recordings in nineteen 6- to 12-year-old children under “passive” and “active” listening conditions. In the passive condition, children were instructed to watch a silent DVD and ignore 566 standard (1,000 Hz) and 100 deviant (1,200 Hz) tones. In the active condition, they listened to the same stimuli, and were asked to count the number of ‘high’ (i.e., deviant) tones. Results. Intraclass correlations (ICCs) indicated that the ERP morphology recorded with the two systems was very similar for the P1, N1, P2, N2, and P3 ERP peaks (r = .82 to .95) in both passive and active conditions, and less so, though still strong, for mismatch negativity ERP component (MMN; r = .67 to .74). There were few differences between peak amplitude and latency estimates for the two systems. Conclusions. An adapted EPOC EEG system can be used to index children’s late auditory ERP peaks (i.e., P1, N1, P2, N2, P3) and their MMN ERP component. PMID:25922794

Validation of the Emotiv EPOC EEG system for research quality auditory event-related potentials in children.

PubMed

Badcock, Nicholas A; Preece, Kathryn A; de Wit, Bianca; Glenn, Katharine; Fieder, Nora; Thie, Johnson; McArthur, Genevieve

2015-01-01

Background. Previous work has demonstrated that a commercial gaming electroencephalography (EEG) system, Emotiv EPOC, can be adjusted to provide valid auditory event-related potentials (ERPs) in adults that are comparable to ERPs recorded by a research-grade EEG system, Neuroscan. The aim of the current study was to determine if the same was true for children. Method. An adapted Emotiv EPOC system and Neuroscan system were used to make simultaneous EEG recordings in nineteen 6- to 12-year-old children under "passive" and "active" listening conditions. In the passive condition, children were instructed to watch a silent DVD and ignore 566 standard (1,000 Hz) and 100 deviant (1,200 Hz) tones. In the active condition, they listened to the same stimuli, and were asked to count the number of 'high' (i.e., deviant) tones. Results. Intraclass correlations (ICCs) indicated that the ERP morphology recorded with the two systems was very similar for the P1, N1, P2, N2, and P3 ERP peaks (r = .82 to .95) in both passive and active conditions, and less so, though still strong, for mismatch negativity ERP component (MMN; r = .67 to .74). There were few differences between peak amplitude and latency estimates for the two systems. Conclusions. An adapted EPOC EEG system can be used to index children's late auditory ERP peaks (i.e., P1, N1, P2, N2, P3) and their MMN ERP component.

The sentence wrap-up dogma.

PubMed

Stowe, Laurie A; Kaan, Edith; Sabourin, Laura; Taylor, Ryan C

2018-03-30

Current sentence processing research has focused on early effects of the on-line incremental processes that are performed at each word or constituent during processing. However, less attention has been devoted to what happens at the end of the clause or sentence. More specifically, over the last decade and a half, a lot of effort has been put into avoiding measuring event-related brain potentials (ERPs) at the final word of a sentence, because of the possible effects of sentence wrap-up. This article reviews the evidence on how and when sentence wrap-up impacts behavioral and ERP results. Even though the end of the sentence is associated with a positive-going ERP wave, thus far this effect has not been associated with any factors hypothesized to affect wrap-up. In addition, ERP responses to violations have not been affected by this positivity. "Sentence-final" negativities reported in the literature are not unique to sentence final positions, nor do they obscure or distort ERP effects associated with linguistic manipulations. Finally, the empirical evidence used to argue that sentence-final ERPs are different from those recorded at sentence-medial positions is weak at most. Measuring ERPs at sentence-final positions is therefore certainly not to be avoided at all costs, especially not in cases where the structure of the language under investigation requires it. More importantly, researchers should follow rigorous method in their experimental design, avoid decision tasks which may induce ERP confounds, and ensure all other possible explanations for results are considered. Although this article is directed at a particular dogma from a particular literature, this review shows that it is important to reassess what is regarded as "general knowledge" from time to time. Copyright © 2018 Elsevier B.V. All rights reserved.

Static renewal tests using Pimephales promelas (fathead minnows) and Ceriodaphnia dubia (daphnids). Clinch River-Environmental Restoration Program (CR-ERP) study, ambient water toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russell, C.L.

1993-12-31

Clinch River-Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a study during the week of July 22--29, 1993. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Surface water samples were collected by TVA Field engineering personnel from Clinch River Mile 19.0 and Mile 22.0 on July 21, 23, and 26. Samples were split and provided to the CR-ERP and TVA toxicology laboratories for testing. Exposure of test organisms to these samples resulted in no toxicity (survival, growth, or reproduction) to either species in testing conducted by TVA. Attachmentsmore » to this report include: Chain of custody forms -- originals; Toxicity test bench sheets and statistical analyses; and Reference toxicant test information.« less

Overcoming Murphy`s Law to gain ERP - a case study at Gibbons Creek Lignite Mine, Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lancaster, E.M.; Horbaczewski, J.K.

1997-12-31

As of January 1997, there are 2,586 acres of reclaimed land in the Extended Responsibility Period (ERP) at Gibbons Creek Lignite Mine, Texas. This achievement has taken approximately five years to accomplish - from 1991 to 1996. During this period, there were a number of issues, some of which appeared to follow Murphy`s Law (whatever can go wrong, will go wrong!). For example, the ERP candidate areas were split among three permit areas, which first had to be consolidated to facilitate the ERP process. Minesoil issues, identified as ERP prerequisites, became entangled in an overall renewal/revision of the newly-consolidated Permitmore » 26B. Special-purpose vegetation studies were performed to investigate the effects of different minesoil textures. In the meantime, small depressional areas, wetland/wildlife enhancement areas, reclamation ponds and restored drainages became the subjects of attention from landowners and regulatory agencies. Some of these structures and features were subsequently reclaimed; others were approved via the permitting process. In some cases, the only way out of the impasse was through land acquisition. Finally, after all these issues had been resolved, an unforeseen oil-well drilling program crisscrossed the proposed ERP areas with a network of oil well pads and service roads, requiring a post-mining land use change. Eventually, whatever could go wrong, went right, and entry of lands into ERP was accomplished.« less

Implementation of false discovery rate for exploring novel paradigms and trait dimensions with ERPs.

PubMed

Crowley, Michael J; Wu, Jia; McCreary, Scott; Miller, Kelly; Mayes, Linda C

2012-01-01

False discovery rate (FDR) is a multiple comparison procedure that targets the expected proportion of false discoveries among the discoveries. Employing FDR methods in event-related potential (ERP) research provides an approach to explore new ERP paradigms and ERP-psychological trait/behavior relations. In Study 1, we examined neural responses to escape behavior from an aversive noise. In Study 2, we correlated a relatively unexplored trait dimension, ostracism, with neural response. In both situations we focused on the frontal cortical region, applying a channel by time plots to display statistically significant uncorrected data and FDR corrected data, controlling for multiple comparisons.

Effect of ecological restoration programs on dust concentrations in the North China Plain: a case study

NASA Astrophysics Data System (ADS)

Long, Xin; Tie, Xuexi; Li, Guohui; Cao, Junji; Feng, Tian; Zhao, Shuyu; Xing, Li; An, Zhisheng

2018-05-01

In recent decades, the Chinese government has made a great effort in initiating large-scale ecological restoration programs (ERPs) to reduce the dust concentrations in China, especially for dust storm episodes. Using the Moderate Resolution Imaging Spectroradiometer (MODIS) land cover product, the ERP-induced land cover changes are quantitatively evaluated in this study. Two obvious vegetation protective barriers arise throughout China from the southwest to the northeast, which are well known as the Green Great Wall (GGW). Both the grass GGW and forest GGW are located between the dust source region (DSR) and the densely populated North China Plain (NCP). To assess the effect of ERPs on dust concentrations, a regional transport/dust model (WRF-DUST, Weather Research and Forecast model with dust) is applied to investigate the evolution of dust plumes during a strong dust storm episode from 2 to 8 March 2016. The WRF-DUST model generally performs reasonably well in reproducing the temporal variations and spatial distributions of near-surface [PMC] (mass concentration of particulate matter with aerodynamic diameter between 2.5 and 10 µm) during the dust storm event. Sensitivity experiments have indicated that the ERP-induced GGWs help to reduce the dust concentration in the NCP, especially in BTH (Beijing, Tianjin, and Hebei). When the dust storm is transported from the upwind DSR to the downwind NCP, the [PMC] reduction ranges from -5 to -15 % in the NCP, with a maximum reduction of -12.4 % (-19.2 µg m-3) in BTH and -7.6 % (-10.1 µg m-3) in the NCP. We find the dust plumes move up to the upper atmosphere and are transported from the upwind DSR to the downwind NCP, accompanied by dust decrease. During the episode, the forest GGW is nonsignificant in dust concentration control because it is of benefit for dry deposition and not for emission. Conversely, the grass GGW is beneficial in controlling dust erosion and is the dominant reason for [PMC] decrease in the NCP. Because the air pollution is severe in eastern China, especially in the NCP, and the contribution of dust episodes is significant, the reduction of dust concentrations will have important effects on severe air pollution. This study illustrates the considerable contribution of ERPs to the control of air pollution in China, especially in springtime.

Attention-dependent sound offset-related brain potentials.

PubMed

Horváth, János

2016-05-01

When performing sensory tasks, knowing the potentially occurring goal-relevant and irrelevant stimulus events allows the establishment of selective attention sets, which result in enhanced sensory processing of goal-relevant events. In the auditory modality, such enhancements are reflected in the increased amplitude of the N1 ERP elicited by the onsets of task-relevant sounds. It has been recently suggested that ERPs to task-relevant sound offsets are similarly enhanced in a tone-focused state in comparison to a distracted one. The goal of the present study was to explore the influence of attention on ERPs elicited by sound offsets. ERPs elicited by tones in a duration-discrimination task were compared to ERPs elicited by the same tones in not-tone-focused attentional setting. Tone offsets elicited a consistent, attention-dependent biphasic (positive-negative--P1-N1) ERP waveform for tone durations ranging from 150 to 450 ms. The evidence, however, did not support the notion that the offset-related ERPs reflected an offset-specific attention set: The offset-related ERPs elicited in a duration-discrimination condition (in which offsets were task relevant) did not significantly differ from those elicited in a pitch-discrimination condition (in which the offsets were task irrelevant). Although an N2 reflecting the processing of offsets in task-related terms contributed to the observed waveform, this contribution was separable from the offset-related P1 and N1. The results demonstrate that when tones are attended, offset-related ERPs may substantially overlap endogenous ERP activity in the postoffset interval irrespective of tone duration, and attention differences may cause ERP differences in such postoffset intervals. © 2016 Society for Psychophysiological Research.

Classifying four-category visual objects using multiple ERP components in single-trial ERP.

PubMed

Qin, Yu; Zhan, Yu; Wang, Changming; Zhang, Jiacai; Yao, Li; Guo, Xiaojuan; Wu, Xia; Hu, Bin

2016-08-01

Object categorization using single-trial electroencephalography (EEG) data measured while participants view images has been studied intensively. In previous studies, multiple event-related potential (ERP) components (e.g., P1, N1, P2, and P3) were used to improve the performance of object categorization of visual stimuli. In this study, we introduce a novel method that uses multiple-kernel support vector machine to fuse multiple ERP component features. We investigate whether fusing the potential complementary information of different ERP components (e.g., P1, N1, P2a, and P2b) can improve the performance of four-category visual object classification in single-trial EEGs. We also compare the classification accuracy of different ERP component fusion methods. Our experimental results indicate that the classification accuracy increases through multiple ERP fusion. Additional comparative analyses indicate that the multiple-kernel fusion method can achieve a mean classification accuracy higher than 72 %, which is substantially better than that achieved with any single ERP component feature (55.07 % for the best single ERP component, N1). We compare the classification results with those of other fusion methods and determine that the accuracy of the multiple-kernel fusion method is 5.47, 4.06, and 16.90 % higher than those of feature concatenation, feature extraction, and decision fusion, respectively. Our study shows that our multiple-kernel fusion method outperforms other fusion methods and thus provides a means to improve the classification performance of single-trial ERPs in brain-computer interface research.

A final report to the Laboratory Directed Research and Development committee on Project 93-ERP-075: ``X-ray laser propagation and coherence: Diagnosing fast-evolving, high-density laser plasmas using X-ray lasers``

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wan, A.S.; Cauble, R.; Da Silva, L.B.

1996-02-01

This report summarizes the major accomplishments of this three-year Laboratory Directed Research and Development (LDRD) Exploratory Research Project (ERP) entitled ``X-ray Laser Propagation and Coherence: Diagnosing Fast-evolving, High-density Laser Plasmas Using X-ray Lasers,`` tracking code 93-ERP-075. The most significant accomplishment of this project is the demonstration of a new laser plasma diagnostic: a soft x-ray Mach-Zehnder interferometer using a neonlike yttrium x-ray laser at 155 {angstrom} as the probe source. Detailed comparisons of absolute two-dimensional electron density profiles obtained from soft x-ray laser interferograms and profiles obtained from radiation hydrodynamics codes, such as LASNEX, will allow us to validate andmore » benchmark complex numerical models used to study the physics of laser-plasma interactions. Thus the development of soft x-ray interferometry technique provides a mechanism to probe the deficiencies of the numerical models and is an important tool for, the high-energy density physics and science-based stockpile stewardship programs. The authors have used the soft x-ray interferometer to study a number of high-density, fast evolving, laser-produced plasmas, such as the dynamics of exploding foils and colliding plasmas. They are pursuing the application of the soft x-ray interferometer to study ICF-relevant plasmas, such as capsules and hohlraums, on the Nova 10-beam facility. They have also studied the development of enhanced-coherence, shorter-pulse-duration, and high-brightness x-ray lasers. The utilization of improved x-ray laser sources can ultimately enable them to obtain three-dimensional holographic images of laser-produced plasmas.« less

Modeling the effects of changes in new source review on national SO2 and NOx emissions from electricity-generating units.

PubMed

Evans, David A; Hobbs, Benjamin F; Oren, Craig; Palmer, Karen L

2008-01-15

The Clean Air Act establishes New Source Review (NSR) programs that apply to construction or modification of major stationary sources. In 2002 and 2003, EPA revised its rules to narrow NSR's coverage of renovations. Congress mandated a National Research Council study of the revisions' impacts. In that study, we used an electricity-sector model to explore possible effects of the equipment replacement provision (ERP), the principal NSR change directed at power plants. We find that, assuming implementation of the Clean Air Interstate Rule (CAIR), tight enforcement of the prerevision NSR rules would likely lead to no or limited decreases in national emissions compared to policies such as ERP. However, emissions might shift forward in time because the previous NSR rules would depress allowance prices, discouraging banking and encouraging allowance use. Only under the most aggressive prerevision NSR enforcement scenario, in which essentially all coal capacity is compelled to retrofit controls by 2020, do NOx emissions fall below ERP levels. Even then, total 2007-2020 SO2 emissions are unaffected. Further decreases in national emissions could be accomplished more cheaply by tighter emissions caps than through NSR because caps provide incentives for efficient operating strategies, such as fuel switching, as well as retrofits.

ERPLAB: an open-source toolbox for the analysis of event-related potentials

PubMed Central

Lopez-Calderon, Javier; Luck, Steven J.

2014-01-01

ERPLAB toolbox is a freely available, open-source toolbox for processing and analyzing event-related potential (ERP) data in the MATLAB environment. ERPLAB is closely integrated with EEGLAB, a popular open-source toolbox that provides many EEG preprocessing steps and an excellent user interface design. ERPLAB adds to EEGLAB’s EEG processing functions, providing additional tools for filtering, artifact detection, re-referencing, and sorting of events, among others. ERPLAB also provides robust tools for averaging EEG segments together to create averaged ERPs, for creating difference waves and other recombinations of ERP waveforms through algebraic expressions, for filtering and re-referencing the averaged ERPs, for plotting ERP waveforms and scalp maps, and for quantifying several types of amplitudes and latencies. ERPLAB’s tools can be accessed either from an easy-to-learn graphical user interface or from MATLAB scripts, and a command history function makes it easy for users with no programming experience to write scripts. Consequently, ERPLAB provides both ease of use and virtually unlimited power and flexibility, making it appropriate for the analysis of both simple and complex ERP experiments. Several forms of documentation are available, including a detailed user’s guide, a step-by-step tutorial, a scripting guide, and a set of video-based demonstrations. PMID:24782741

ERPLAB: an open-source toolbox for the analysis of event-related potentials.

PubMed

Lopez-Calderon, Javier; Luck, Steven J

2014-01-01

ERPLAB toolbox is a freely available, open-source toolbox for processing and analyzing event-related potential (ERP) data in the MATLAB environment. ERPLAB is closely integrated with EEGLAB, a popular open-source toolbox that provides many EEG preprocessing steps and an excellent user interface design. ERPLAB adds to EEGLAB's EEG processing functions, providing additional tools for filtering, artifact detection, re-referencing, and sorting of events, among others. ERPLAB also provides robust tools for averaging EEG segments together to create averaged ERPs, for creating difference waves and other recombinations of ERP waveforms through algebraic expressions, for filtering and re-referencing the averaged ERPs, for plotting ERP waveforms and scalp maps, and for quantifying several types of amplitudes and latencies. ERPLAB's tools can be accessed either from an easy-to-learn graphical user interface or from MATLAB scripts, and a command history function makes it easy for users with no programming experience to write scripts. Consequently, ERPLAB provides both ease of use and virtually unlimited power and flexibility, making it appropriate for the analysis of both simple and complex ERP experiments. Several forms of documentation are available, including a detailed user's guide, a step-by-step tutorial, a scripting guide, and a set of video-based demonstrations.

Surgical Technical Evidence Review of Hip Fracture Surgery Conducted for the AHRQ Safety Program for Improving Surgical Care and Recovery.

PubMed

Siletz, Anaar; Childers, Christopher P; Faltermeier, Claire; Singer, Emily S; Hu, Q Lina; Ko, Clifford Y; Kates, Stephen L; Maggard-Gibbons, Melinda; Wick, Elizabeth

2018-01-01

Enhanced recovery pathways (ERPs) have been shown to improve patient outcomes in a variety of contexts. This review summarizes the evidence and defines a protocol for perioperative care of patients with hip fracture and was conducted for the Agency for Healthcare Research and Quality safety program for improving surgical care and recovery. Perioperative care was divided into components or "bins." For each bin, a semisystematic review of the literature was conducted using MEDLINE with priority given to systematic reviews, meta-analyses, and randomized controlled trials. Observational studies were included when higher levels of evidence were not available. Existing guidelines for perioperative care were also incorporated. For convenience, the components of care that are under the auspices of anesthesia providers will be reported separately. Recommendations for an evidence-based protocol were synthesized based on review of this evidence. Eleven bins were identified. Preoperative risk factor bins included nutrition, diabetes mellitus, tobacco use, and anemia. Perioperative management bins included thromboprophylaxis, timing of surgery, fluid management, drain placement, early mobilization, early alimentation, and discharge criteria/planning. This review provides the evidence basis for an ERP for perioperative care of patients with hip fracture.

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research.

PubMed

Turcios, Jacqueline; Cook, Barbara; Irwin, Julia; Rispoli, Taylor; Landi, Nicole

2017-07-31

This paper includes a detailed description of a familiarization protocol, which is used as an integral component of a larger research protocol to collect electroencephalography (EEG) data and Event-Related Potentials (ERPs). At present, the systems available for the collection of high-quality EEG/ERP data make significant demands on children with developmental disabilities, such as those with an Autism Spectrum Disorder (ASD). Children with ASD may have difficulty adapting to novel situations, tolerating uncomfortable sensory stimuli, and sitting quietly. This familiarization protocol uses Evidence-Based Practices (EBPs) to increase research participants' knowledge and understanding of the specific activities and steps of the research protocol. The tools in this familiarization protocol are a social narrative, a visual schedule, the Premack principle, role-playing, and modeling. The goal of this familiarization protocol is to increase understanding and agency and to potentially reduce anxiety for child participants, resulting in a greater likelihood of the successful completion of the research protocol for the collection of EEG/ERP data.

Clinch River - Environmental Restoration Program (CR-ERP) study, Ambient water toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1997-06-01

Clinch River - Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a study during the week of January 25-February 1, 1994, as described in the Statement of Work (SOW) document. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Surface water samples were collected by TVA Field Engineering personnel from Clinch River Mile 9.0, Poplar Creek Mile 1.0, and Poplar Creek Mile 2.9 on January 24, 26, and 28. Samples were partitioned (split) and provided to the CR-ERP and TVA toxicology laboratories for testing. Exposure of test organisms tomore » these samples resulted in no toxicity (survival or growth) to fathead minnows; however, toxicity to daphnids (significantly reduced reproduction) was demonstrated in undiluted samples from Poplar Creek Mile 1.0 in testing conducted by TVA based on hypothesis testing of data. Point estimation (IC{sub 25}) analysis of the data, however, showed no toxicity in PCM 1.0 samples.« less

The Use of Electroencephalography in Language Production Research: A Review

PubMed Central

Ganushchak, Lesya Y.; Christoffels, Ingrid K.; Schiller, Niels O.

2011-01-01

Speech production long avoided electrophysiological experiments due to the suspicion that potential artifacts caused by muscle activity of overt speech may lead to a bad signal-to-noise ratio in the measurements. Therefore, researchers have sought to assess speech production by using indirect speech production tasks, such as tacit or implicit naming, delayed naming, or meta-linguistic tasks, such as phoneme-monitoring. Covert speech may, however, involve different processes than overt speech production. Recently, overt speech has been investigated using electroencephalography (EEG). As the number of papers published is rising steadily, this clearly indicates the increasing interest and demand for overt speech research within the field of cognitive neuroscience of language. Our main goal here is to review all currently available results of overt speech production involving EEG measurements, such as picture naming, Stroop naming, and reading aloud. We conclude that overt speech production can be successfully studied using electrophysiological measures, for instance, event-related brain potentials (ERPs). We will discuss possible relevant components in the ERP waveform of speech production and aim to address the issue of how to interpret the results of ERP research using overt speech, and whether the ERP components in language production are comparable to results from other fields. PMID:21909333

A case study of exploiting enterprise resource planning requirements

NASA Astrophysics Data System (ADS)

Niu, Nan; Jin, Mingzhou; Cheng, Jing-Ru C.

2011-05-01

The requirements engineering (RE) processes have become a key to conceptualising corporate-wide integrated solutions based on packaged enterprise resource planning (ERP) software. The RE literature has mainly focused on procuring the most suitable ERP package. Little is known about how an organisation exploits the chosen ERP RE model to frame the business application development. This article reports an exploratory case study of a key tenet of ERP RE adoption, namely that aligning business applications to the packaged RE model leads to integral practices and economic development. The case study analysed a series interrelated pilot projects developed for a business division of a large IT manufacturing and service company, using Oracle's appl1ication implementation method (AIM). The study indicated that AIM RE improved team collaboration and project management experience, but needed to make hidden assumptions explicit to support data visibility and integrity. Our study can direct researchers towards rigorous empirical evaluations of ERP RE adoption, collect experiences and lessons learned for practitioners, and help generate more effective and mature processes when exploiting ERP RE methods.

The effect of a movie soundtrack on auditory event-related potentials in children, adolescents, and adults.

PubMed

Mahajan, Yatin; McArthur, Genevieve

2011-05-01

To determine if an audible movie soundtrack has a degrading effect on the auditory P1, N1, P2, N2, or mismatch negativity (MMN) event-related potentials (ERPs) in children, adolescents, or adults. The auditory ERPs of 36 children, 32 young adolescents, 19 older adolescents, and 10 adults were measured while they watched a movie in two conditions: with an audible soundtrack and with a silent soundtrack. In children and adolescents, the audible movie soundtrack had a significant impact on amplitude, latency or split-half reliability of the N1, P2, N2, and MMN ERPs. The audible soundtrack had minimal impact on the auditory ERPs of adults. These findings challenge previous claims that an audible soundtrack does not degrade the auditory ERPs of children. Further, the reliability of the MMN is poorer than P1, N1, P2, and N2 peaks in both sound-off and sound-on conditions. Researchers should be cautious about using an audible movie soundtrack when measuring auditory ERPs in younger listeners. Copyright © 2010 International Federation of Clinical Neurophysiology. All rights reserved.

After-effects of human-computer interaction indicated by P300 of the event-related brain potential.

PubMed

Trimmel, M; Huber, R

1998-05-01

After-effects of human-computer interaction (HCI) were investigated by using the P300 component of the event-related brain potential (ERP). Forty-nine subjects (naive non-users, beginners, experienced users, programmers) completed three paper/pencil tasks (text editing, solving intelligence test items, filling out a questionnaire on sensation seeking) and three HCI tasks (text editing, executing a tutor program or programming, playing Tetris). The sequence of 7-min tasks was randomized between subjects and balanced between groups. After each experimental condition ERPs were recorded during an acoustic discrimination task at F3, F4, Cz, P3 and P4. Data indicate that: (1) mental after-effects of HCI can be detected by P300 of the ERP; (2) HCI showed in general a reduced amplitude; (3) P300 amplitude varied also with type of task, mainly at F4 where it was smaller after cognitive tasks (intelligence test/programming) and larger after emotion-based tasks (sensation seeking/Tetris); (4) cognitive tasks showed shorter latencies; (5) latencies were widely location-independent (within the range of 356-358 ms at F3, F4, P3 and P4) after executing the tutor program or programming; and (6) all observed after-effects were independent of the user's experience in operating computers and may therefore reflect short-term after-effects only and no structural changes of information processing caused by HCI.

Electrophysiological assessments of cognition and sensory processing in TBI: applications for diagnosis, prognosis and rehabilitation.

PubMed

Folmer, Robert L; Billings, Curtis J; Diedesch-Rouse, Anna C; Gallun, Frederick J; Lew, Henry L

2011-10-01

Traumatic brain injuries are often associated with damage to sensory and cognitive processing pathways. Because evoked potentials (EPs) and event-related potentials (ERPs) are generated by neuronal activity, they are useful for assessing the integrity of neural processing capabilities in patients with traumatic brain injury (TBI). This review of somatosensory, auditory and visual ERPs in assessments of TBI patients is provided with the hope that it will be of interest to clinicians and researchers who conduct or interpret electrophysiological evaluations of this population. Because this article reviews ERP studies conducted in three different sensory modalities, involving patients with a wide range of TBI severity ratings and circumstances, it is difficult to provide a coherent summary of findings. However, some general trends emerge that give rise to the following observations and recommendations: 1) bilateral absence of somatosensory evoked potentials (SEPs) is often associated with poor clinical prognosis and outcome; 2) the presence of normal ERPs does not guarantee favorable outcome; 3) ERPs evoked by a variety of sensory stimuli should be used to evaluate TBI patients, especially those with severe injuries; 4) time since onset of injury should be taken into account when conducting ERP evaluations of TBI patients or interpreting results; 5) because sensory deficits (e.g., vision impairment or hearing loss) affect ERP results, tests of peripheral sensory integrity should be conducted in conjunction with ERP recordings; and 6) patients' state of consciousness, physical and cognitive abilities to respond and follow directions should be considered when conducting or interpreting ERP evaluations. Published by Elsevier B.V.

El Sistema-inspired ensemble music training is associated with changes in children's neurocognitive functional integration: preliminary ERP evidence.

PubMed

Hedayati, Nina; Schibli, Kylie; D'Angiulli, Amedeo

2016-12-01

Children (aged 9-12) training in an El Sistema-inspired program (OrKidstra) and a matched comparison group participated in an auditory Go/No-Go task while event-related potentials (ERPs) were recorded. Entire-sweep waveform patterns correlated with known ERP peaks associated with executive and other cognitive functions and indicated that the spread of neural activity in the initial 250 ms of executive attention processing (pre-P300) showed higher level of topographical overlap in OrKidstra children. In these children, late potentials (post-P300) concurrent with response control were more widely distributed and temporally coordinated. Intensive ensemble music training, we suggest, may be associated with neuroplastic changes facilitating integration of neural information.

Analysis of the interaction of calcitriol with the disulfide isomerase ERp57

NASA Astrophysics Data System (ADS)

Gaucci, Elisa; Raimondo, Domenico; Grillo, Caterina; Cervoni, Laura; Altieri, Fabio; Nittari, Giulio; Eufemi, Margherita; Chichiarelli, Silvia

2016-11-01

Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane-associated receptor, which has been discovered as the disulfide isomerase ERp57. The aim of our research is to identify the binding sites for calcitriol in ERp57 and to analyze their interaction. We first studied the interaction through bioinformatics and fluorimetric analyses. Subsequently, we focused on two protein mutants containing the predicted interaction domains with calcitriol: abb’-ERp57, containing the first three domains, and a’-ERp57, the fourth domain only. To consolidate the achievements we used the calorimetric approach to the whole protein and its mutants. Our results allow us to hypothesize that the interaction with the a’ domain contributes to a greater extent than the other potential binding sites to the dissociation constant, calculated as a Kd of about 10-9 M.

Emotion regulation in the brain: conceptual issues and directions for developmental research.

PubMed

Lewis, Marc D; Stieben, Jim

2004-01-01

Emotion regulation cannot be temporally distinguished from emotion in the brain, but activation patterns in prefrontal cortex appear to mediate cognitive control during emotion episodes. Frontal event-related potentials (ERPs) can tap cognitive control hypothetically mediated by the anterior cingulate cortex, and developmentalists have used these to differentiate age, individual, and emotion-valence factors. Extending this approach, the present article outlines a research strategy for studying emotion regulation in children by combining emotion induction with a go/no-go task known to produce frontal ERPs. Preliminary results indicate that medial-frontal ERP amplitudes diminish with age but become more sensitive to anxiety, and internalizing children show higher amplitudes than noninternalizing children, especially when anxious. These results may reflect age and individual differences in the effortful regulation of negative emotion.

Modeling the effects of changes in new source review on national SO{sub 2} and NOx emissions from electricity-generating units

DOE Office of Scientific and Technical Information (OSTI.GOV)

David A. Evans; Benjamin F. Hobbs; Craig Oren

2008-01-15

The Clean Air Act establishes New Source Review (NSR) programs that apply to construction or modification of major stationary sources. In 2002 and 2003, EPA revised its rules to narrow NSR's coverage of renovations. Congress mandated a National Research Council study of the revisions' impacts. In that study, we used an electricity-sector model to explore possible effects of the equipment replacement provision (ERP), the principal NSR change directed at power plants. We find that, assuming implementation of the Clean Air Interstate Rule (CAIR), tight enforcement of the prerevision NSR rules would likely lead to no or limited decreases in nationalmore » emissions compared to policies such as ERP. However, emissions might shift forward in time because the previous NSR rules would depress allowance prices, discouraging banking and encouraging allowance use. Only under the most aggressive prerevision NSR enforcement scenario, in which essentially all coal capacity is compelled to retrofit controls by 2020, do NOx emissions fall below ERP levels. Even then, total 2007-2020 SO{sub 2} emissions are unaffected. Further decreases in national emissions could be accomplished more cheaply by tighter emissions caps than through NSR because caps provide incentives for efficient operating strategies, such as fuel switching, as well as retrofits. 23 refs., 2 figs., 1 tab.« less

Research on ERP Teaching Model Reform for Application-Oriented Talents Education

ERIC Educational Resources Information Center

Fan, Chongjun; Zhang, Peng; Liu, Qin; Yang, Jianzheng; Xi, Wanyu

2011-01-01

Enterprise Resource Planning is one of the core courses of management. According to the educational characteristics of application-oriented talents training, this paper discussed the issues of ERP teaching for application-oriented talents training at present and proposed a number of ideas and strategies in the aspects of modifying the teaching…

Brain Event-Related Potential Correlates of Concept Learning.

ERIC Educational Resources Information Center

Federico, Pat-Anthony

An irrelevant auditory probe procedure was used to evoke brain event-related potentials (ERPs) in 56 Navy recruits while they learned pulsed radar concepts presented to them in study booklets. A mastery test was administered to assess concept acquisition. The research issue was whether brain ERPs recorded while students are in the process of…

Comparing Objective Measures and Perceptions of Cognitive Learning in an ERP Simulation Game: A Research Note

ERIC Educational Resources Information Center

Cronan, Timothy Paul; Leger, Pierre-Majorique; Robert, Jacques; Babin, Gilbert; Charland, Patrick

2012-01-01

Enterprise Resource Planning (ERP) systems have had a significant impact on business organizations. These large systems offer opportunities for companies regarding the integration and functionality of information technology systems; in effect, companies can realize a competitive advantage that is necessary in today's global companies. However,…

Motion Sickness When Driving With a Head-Slaved Camera System

DTIC Science & Technology

2003-02-01

YPR-765 under armour (Report TM-97-A026). Soesterberg, The Netherlands: TNO Human Factors Research Institute. Van Erp, J.B.F., Padmos, P. & Tenkink, E...Institute. Van Erp, J.B.F., Van den Dobbelsteen, J.J. & Padmos, P. (1998). Improved camera-monitor system for driving YPR-765 under armour (Report TM-98

The Determinants of Student Effort at Learning ERP: A Cultural Perspective

ERIC Educational Resources Information Center

Alshare, Khaled A.; El-Masri, Mazen; Lane, Peggy L.

2015-01-01

This paper develops a research model based on the Unified Theory of Acceptance and Use of Technology model (UTAUT) and Hofstede's cultural dimensions to explore factors that influence student effort at learning Enterprise Resource Planning (ERP) systems. A Structural Equation Model (SEM) using LISREL was utilized to validate the proposed research…

Quantifying the Time Course of Visual Object Processing Using ERPs: It's Time to Up the Game

PubMed Central

Rousselet, Guillaume A.; Pernet, Cyril R.

2011-01-01

Hundreds of studies have investigated the early ERPs to faces and objects using scalp and intracranial recordings. The vast majority of these studies have used uncontrolled stimuli, inappropriate designs, peak measurements, poor figures, and poor inferential and descriptive group statistics. These problems, together with a tendency to discuss any effect p < 0.05 rather than to report effect sizes, have led to a research field very much qualitative in nature, despite its quantitative inspirations, and in which predictions do not go beyond condition A > condition B. Here we describe the main limitations of face and object ERP research and suggest alternative strategies to move forward. The problems plague intracranial and surface ERP studies, but also studies using more advanced techniques – e.g., source space analyses and measurements of network dynamics, as well as many behavioral, fMRI, TMS, and LFP studies. In essence, it is time to stop amassing binary results and start using single-trial analyses to build models of visual perception. PMID:21779262

Overview of external reference pricing systems in Europe

PubMed Central

Rémuzat, Cécile; Urbinati, Duccio; Mzoughi, Olfa; El Hammi, Emna; Belgaied, Wael; Toumi, Mondher

2015-01-01

Background and objectives External reference pricing (ERP) is a price regulation tool widely used by policy makers in the European Union (EU) Member States (MS) to contain drug cost, although in theory, it may contribute to modulate prices up and down. The objective of this article was to summarise and discuss the main findings of part of a large project conducted for the European Commission (‘External reference pricing of medicinal products: simulation-based considerations for cross-country coordination’; see www.ec.europa.eu/health/healthcare/docs/erp_reimbursement_medicinal_products_en.pdf) that aimed to provide an overview of ERP systems, both on processes and potential issues in 31 European countries (28 EU MS, Iceland, Norway, and Switzerland). Methods A systematic structured literature review was conducted to identify and characterise the use of ERP in the selected countries, to describe its impact on the prices of pharmaceuticals, and to discuss the possible cross-country coordination issues in EU MS. This research was complemented with a consultation of competent authorities’ and international organisations’ representatives to address the main issues or uncertainties identified through the literature review. Results All selected countries applied ERP, except the United Kingdom and Sweden. Twenty-three countries used ERP as the main systematic criterion for pricing. In the majority of European countries, ERP was based on legislated pricing rules with different levels of accuracy. ERP was applied either for all marketed drugs or for specific categories of medicines; it was mainly used for publicly reimbursed medicines. The number of reference countries included in the basket varied from 1 to 31. There was a great variation in the calculation methods used to compute the price; 15 countries used the average price, 7 countries used the lowest price, and 7 countries used other calculation methods. Reported limitations of ERP application included the lack of reliable sources of price information, price heterogeneity, exchange rate volatility, and hidden discounts. Spill-over effect and downward price convergence have often been mentioned as ERP's consequences leading to pricing strategies from pharmaceutical companies. Conclusion While ERP is widely used in Europe, processes and availability of price information vary from one country to another, thus limiting ERP implementation. Furthermore, ERP spill-over effect is a major concern of pharmaceutical firms leading to implementation of the so-called ‘launch sequence strategies’. PMID:27123181

Overview of external reference pricing systems in Europe.

PubMed

Rémuzat, Cécile; Urbinati, Duccio; Mzoughi, Olfa; El Hammi, Emna; Belgaied, Wael; Toumi, Mondher

2015-01-01

External reference pricing (ERP) is a price regulation tool widely used by policy makers in the European Union (EU) Member States (MS) to contain drug cost, although in theory, it may contribute to modulate prices up and down. The objective of this article was to summarise and discuss the main findings of part of a large project conducted for the European Commission ('External reference pricing of medicinal products: simulation-based considerations for cross-country coordination'; see www.ec.europa.eu/health/healthcare/docs/erp_reimbursement_medicinal_products_en.pdf) that aimed to provide an overview of ERP systems, both on processes and potential issues in 31 European countries (28 EU MS, Iceland, Norway, and Switzerland). A systematic structured literature review was conducted to identify and characterise the use of ERP in the selected countries, to describe its impact on the prices of pharmaceuticals, and to discuss the possible cross-country coordination issues in EU MS. This research was complemented with a consultation of competent authorities' and international organisations' representatives to address the main issues or uncertainties identified through the literature review. All selected countries applied ERP, except the United Kingdom and Sweden. Twenty-three countries used ERP as the main systematic criterion for pricing. In the majority of European countries, ERP was based on legislated pricing rules with different levels of accuracy. ERP was applied either for all marketed drugs or for specific categories of medicines; it was mainly used for publicly reimbursed medicines. The number of reference countries included in the basket varied from 1 to 31. There was a great variation in the calculation methods used to compute the price; 15 countries used the average price, 7 countries used the lowest price, and 7 countries used other calculation methods. Reported limitations of ERP application included the lack of reliable sources of price information, price heterogeneity, exchange rate volatility, and hidden discounts. Spill-over effect and downward price convergence have often been mentioned as ERP's consequences leading to pricing strategies from pharmaceutical companies. While ERP is widely used in Europe, processes and availability of price information vary from one country to another, thus limiting ERP implementation. Furthermore, ERP spill-over effect is a major concern of pharmaceutical firms leading to implementation of the so-called 'launch sequence strategies'.

Acquiring research-grade ERPs on a shoestring budget: A comparison of a modified Emotiv and commercial SynAmps EEG system.

PubMed

Barham, Michael P; Clark, Gillian M; Hayden, Melissa J; Enticott, Peter G; Conduit, Russell; Lum, Jarrad A G

2017-09-01

This study compared the performance of a low-cost wireless EEG system to a research-grade EEG system on an auditory oddball task designed to elicit N200 and P300 ERP components. Participants were 15 healthy adults (6 female) aged between 19 and 40 (M = 28.56; SD = 6.38). An auditory oddball task was presented comprising 1,200 presentations of a standard tone interspersed by 300 trials comprising a deviant tone. EEG was simultaneously recorded from a modified Emotiv EPOC and a NeuroScan SynAmps RT EEG system. The modifications made to the Emotiv system included attaching research grade electrodes to the Bluetooth transmitter. Additional modifications enabled the Emotiv system to connect to a portable impedance meter. The cost of these modifications and portable impedance meter approached the purchase value of the Emotiv system. Preliminary analyses revealed significantly more trials were rejected from data acquired by the modified Emotiv compared to the SynAmps system. However, the ERP waveforms captured by the Emotiv system were found to be highly similar to the corresponding waveform from the SynAmps system. The latency and peak amplitude of N200 and P300 components were also found to be similar between systems. Overall, the results indicate that, in the context of an oddball task, the ERP acquired by a low-cost wireless EEG system can be of comparable quality to research-grade EEG acquisition equipment. © 2017 Society for Psychophysiological Research.

Measuring the face-sensitive N170 with a gaming EEG system: A validation study.

PubMed

de Lissa, Peter; Sörensen, Sidsel; Badcock, Nicholas; Thie, Johnson; McArthur, Genevieve

2015-09-30

The N170 is a "face-sensitive" event-related potential (ERP) that occurs at around 170ms over occipito-temporal brain regions. The N170's potential to provide insight into the neural processing of faces in certain populations (e.g., children and adults with cognitive impairments) is limited by its measurement in scientific laboratories that can appear threatening to some people. The advent of cheap, easy-to-use portable gaming EEG systems provides an opportunity to record EEG in new contexts and populations. This study tested the validity of the face-sensitive N170 ERP measured with an adapted commercial EEG system (the Emotiv EPOC) that is used at home by gamers. The N170 recorded through both the gaming EEG system and the research EEG system exhibited face-sensitivity, with larger mean amplitudes in response to the face stimuli than the non-face stimuli, and a delayed N170 peak in response to face inversion. The EPOC system produced very similar N170 ERPs to a research-grade Neuroscan system, and was capable of recording face-sensitivity in the N170, validating its use as research tool in this arena. This opens new possibilities for measuring the face-sensitive N170 ERP in people who cannot travel to a traditional ERP laboratory (e.g., elderly people in care), who cannot tolerate laboratory conditions (e.g., people with autism), or who need to be tested in situ for practical or experimental reasons (e.g., children in schools). Copyright © 2015 Elsevier B.V. All rights reserved.

Test-retest reliability of infant event related potentials evoked by faces.

PubMed

Munsters, N M; van Ravenswaaij, H; van den Boomen, C; Kemner, C

2017-04-05

Reliable measures are required to draw meaningful conclusions regarding developmental changes in longitudinal studies. Little is known, however, about the test-retest reliability of face-sensitive event related potentials (ERPs), a frequently used neural measure in infants. The aim of the current study is to investigate the test-retest reliability of ERPs typically evoked by faces in 9-10 month-old infants. The infants (N=31) were presented with neutral, fearful and happy faces that contained only the lower or higher spatial frequency information. They were tested twice within two weeks. The present results show that the test-retest reliability of the face-sensitive ERP components is moderate (P400 and Nc) to substantial (N290). However, there is low test-retest reliability for the effects of the specific experimental manipulations (i.e. emotion and spatial frequency) on the face-sensitive ERPs. To conclude, in infants the face-sensitive ERP components (i.e. N290, P400 and Nc) show adequate test-retest reliability, but not the effects of emotion and spatial frequency on these ERP components. We propose that further research focuses on investigating elements that might increase the test-retest reliability, as adequate test-retest reliability is necessary to draw meaningful conclusions on individual developmental trajectories of the face-sensitive ERPs in infants. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Enterprise resource planning (ERP) implementation using the value engineering methodology and Six Sigma tools

NASA Astrophysics Data System (ADS)

Leu, Jun-Der; Lee, Larry Jung-Hsing

2017-09-01

Enterprise resource planning (ERP) is a software solution that integrates the operational processes of the business functions of an enterprise. However, implementing ERP systems is a complex process. In addition to the technical issues, companies must address problems associated with business process re-engineering, time and budget control, and organisational change. Numerous industrial studies have shown that the failure rate of ERP implementation is high, even for well-designed systems. Thus, ERP projects typically require a clear methodology to support the project execution and effectiveness. In this study, we propose a theoretical model for ERP implementation. The value engineering (VE) method forms the basis of the proposed framework, which integrates Six Sigma tools. The proposed framework encompasses five phases: knowledge generation, analysis, creation, development and execution. In the VE method, potential ERP problems related to software, hardware, consultation and organisation are analysed in a group-decision manner and in relation to value, and Six Sigma tools are applied to avoid any project defects. We validate the feasibility of the proposed model by applying it to an international manufacturing enterprise in Taiwan. The results show improvements in customer response time and operational efficiency in terms of work-in-process and turnover of materials. Based on the evidence from the case study, the theoretical framework is discussed together with the study's limitations and suggestions for future research.

Static renewal tests using Pimephales promelas (fathead minnows) and Ceriodaphnia dubia (daphnids). Clinch River-Environmental Restoration Program (CR-ERP) study, ambient water toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1994-12-31

Clinch River-Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a study during the week of January 25--February 1, 1994. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Surface water samples were collected from Clinch River Mile 9.0, Poplar Creek Mile 1.0, and Poplar Creek Mile 2.9 on January 24, 26, and 28. Samples were partitioned and provided to the CR-ERP and TVA toxicology laboratories for testing. Exposure of test organisms to these samples resulted in no toxicity (survival or growth) to fathead minnows; however, toxicity to daphnids wasmore » demonstrated in undiluted samples from Poplar Creek Mile 1.0 in testing conducted by TVA based on hypothesis testing of data. Point estimation (IC{sub 25}) analysis of the data, however, showed no toxicity in PCM 1.0 samples. Attachments to this report include: Chain of custody forms -- originals; Toxicity test bench sheets and statistical analyses; Meter calibrations; and Reference toxicant test information.« less

Early differential processing of material images: Evidence from ERP classification.

PubMed

Wiebel, Christiane B; Valsecchi, Matteo; Gegenfurtner, Karl R

2014-06-24

Investigating the temporal dynamics of natural image processing using event-related potentials (ERPs) has a long tradition in object recognition research. In a classical Go-NoGo task two characteristic effects have been emphasized: an early task independent category effect and a later task-dependent target effect. Here, we set out to use this well-established Go-NoGo paradigm to study the time course of material categorization. Material perception has gained more and more interest over the years as its importance in natural viewing conditions has been ignored for a long time. In addition to analyzing standard ERPs, we conducted a single trial ERP pattern analysis. To validate this procedure, we also measured ERPs in two object categories (people and animals). Our linear classification procedure was able to largely capture the overall pattern of results from the canonical analysis of the ERPs and even extend it. We replicate the known target effect (differential Go-NoGo potential at frontal sites) for the material images. Furthermore, we observe task-independent differential activity between the two material categories as early as 140 ms after stimulus onset. Using our linear classification approach, we show that material categories can be differentiated consistently based on the ERP pattern in single trials around 100 ms after stimulus onset, independent of the target-related status. This strengthens the idea of early differential visual processing of material categories independent of the task, probably due to differences in low-level image properties and suggests pattern classification of ERP topographies as a strong instrument for investigating electrophysiological brain activity. © 2014 ARVO.

Surgical Technical Evidence Review of Hip Fracture Surgery Conducted for the AHRQ Safety Program for Improving Surgical Care and Recovery

PubMed Central

Siletz, Anaar; Faltermeier, Claire; Singer, Emily S.; Hu, Q. Lina; Ko, Clifford Y.; Kates, Stephen L.; Maggard-Gibbons, Melinda; Wick, Elizabeth

2018-01-01

Background: Enhanced recovery pathways (ERPs) have been shown to improve patient outcomes in a variety of contexts. This review summarizes the evidence and defines a protocol for perioperative care of patients with hip fracture and was conducted for the Agency for Healthcare Research and Quality safety program for improving surgical care and recovery. Study Design: Perioperative care was divided into components or “bins.” For each bin, a semisystematic review of the literature was conducted using MEDLINE with priority given to systematic reviews, meta-analyses, and randomized controlled trials. Observational studies were included when higher levels of evidence were not available. Existing guidelines for perioperative care were also incorporated. For convenience, the components of care that are under the auspices of anesthesia providers will be reported separately. Recommendations for an evidence-based protocol were synthesized based on review of this evidence. Results: Eleven bins were identified. Preoperative risk factor bins included nutrition, diabetes mellitus, tobacco use, and anemia. Perioperative management bins included thromboprophylaxis, timing of surgery, fluid management, drain placement, early mobilization, early alimentation, and discharge criteria/planning. Conclusions: This review provides the evidence basis for an ERP for perioperative care of patients with hip fracture. PMID:29844947

Static renewal tests using Anodonta imbecillis (freshwater mussels). Anodonta imbecillis QA test 4, Clinch River-Environmental Restoration Program (CR-ERP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1994-12-31

Toxicity testing of split whole sediment samples using juvenile freshwater mussels (Anodonta imbecillis) was conducted by TVA to provide a quality assurance mechanism for test organisms quality and overall performance of the test being conducted by CR-ERP personnel as part of the CR-ERP biomonitoring study of Clinch River sediments. Testing of sediment samples collected September 8 from Poplar Creek Miles 6.0 and 1.0 was conducted September 13--22, 1994. Results from this test showed no toxicity (survival effects) to fresh-water mussels during a 9-day exposure to the sediments. Attachments to this report include: Chain of custody form -- original; Toxicity testmore » bench sheets; Ammonia analysis request and results; and Meter calibration log sheets.« less

An ERP Study of the Processing of Subject and Object Relative Clauses in Japanese

ERIC Educational Resources Information Center

Ueno, Mieko; Garnsey, Susan M.

2008-01-01

Using reading times and event-related brain potentials (ERPs), we investigated the processing of Japanese subject and object relative clauses (SRs/ORs). Previous research on English relative clauses shows that ORs take longer to read (King & Just, 1991) and elicit anterior negativity between fillers and gaps (King & Kutas, 1995), which is…

Does Solving Insight-Based Problems Differ from Solving Learning-Based Problems? Some Evidence from an ERP Study

ERIC Educational Resources Information Center

Leikin, Roza; Waisman, Ilana; Leikin, Mark

2016-01-01

We asked: "What are the similarities and differences in mathematical processing associated with solving learning-based and insight-based problems?" To answer this question, the ERP research procedure was employed with 69 male adolescent subjects who solved specially designed insight-based and learning-based tests. Solutions of…

Measuring Business Process Learning with Enterprise Resource Planning Systems to Improve the Value of Education

ERIC Educational Resources Information Center

Monk, Ellen F.; Lycett, Mark

2016-01-01

Enterprise Resource Planning Systems (ERP) are very large and complex software packages that run every aspect of an organization. Increasingly, ERP systems are being used in higher education as one way to teach business processes, essential knowledge for students competing in today's business environment. Past research attempting to measure…

Conceptual Integration of Arithmetic Operations with Real-World Knowledge: Evidence from Event-Related Potentials

ERIC Educational Resources Information Center

Guthormsen, Amy M.; Fisher, Kristie J.; Bassok, Miriam; Osterhout, Lee; DeWolf, Melissa; Holyoak, Keith J.

2016-01-01

Research on language processing has shown that the disruption of conceptual integration gives rise to specific patterns of event-related brain potentials (ERPs)--N400 and P600 effects. Here, we report similar ERP effects when adults performed cross-domain conceptual integration of analogous semantic and mathematical relations. In a problem-solving…

Pay attention to me! Late ERPs reveal gender differences in attention allocated to romantic partners.

PubMed

Burdwood, Erin N; Simons, Robert F

2016-04-01

The present study employed late ERPs to examine differences in the association between neural responses to romantic partners and relationship quality factors across men and women. Participants passively viewed photos of their romantic partners, celebrities, and strangers during a computerized facial processing task. All participants demonstrated enhanced positivity to partner faces at late ERP components (P3 and LPP), furthering the notion that significant others elicit more motivated and sustained attention than do other familiar or unfamiliar individuals. Neural responses to romantic partner faces were influenced by factors including overall relationship quality, investment, and communication quality, with associations varying by gender. Results highlight the key role that relationship quality factors play in the immediate processing of romantic partners-a finding with implications for couples counseling and research. © 2015 Society for Psychophysiological Research.

Social context modulates cognitive markers in Obsessive-Compulsive Disorder.

PubMed

Santamaría-García, Hernando; Soriano-Mas, Carles; Burgaleta, Miguel; Ayneto, Alba; Alonso, Pino; Menchón, José M; Cardoner, Narcis; Sebastián-Gallés, Nuria

2017-08-03

Error monitoring, cognitive control and motor inhibition control are proposed as cognitive alterations disrupted in obsessive-compulsive disorder (OCD). OCD has also been associated with an increased sensitivity to social evaluations. The effect of a social simulation over electrophysiological indices of cognitive alterations in OCD was examined. A case-control cross-sectional study measuring event-related potentials (ERP) for error monitoring (Error-Related Negativity), cognitive control (N2) and motor control (LRP) was conducted. We analyzed twenty OCD patients and twenty control participants. ERP were recorded during a social game consisting of a visual discrimination task, which was performed in the presence of a simulated superior or an inferior player. Significant social effects (different ERP amplitudes in Superior vs. Inferior player conditions) were found for OCD patients, but not for controls, in all ERP components. Performing the task against a simulated inferior player reduced abnormal ERP responses in OCD to levels observed in controls. The hierarchy-induced ERP effects were accompanied effects over reaction times in OCD patients. Social context modulates signatures of abnormal cognitive functioning in OCD, therefore experiencing a social superiority position impacts over cognitive processes in OCD such as error monitoring mechanisms. These results open the door for the research of new therapeutic choices.

The influence of caffeine on sustained attention: an ERP study.

PubMed

Ruijter, J; Lorist, M M; Snel, J; De Ruiter, M B

2000-05-01

The present study investigated the effects of caffeine on sustained attention by measuring concentration and fatigue. Event-related potentials (ERPs) and behavioral measures were recorded from 12 participants who worked continuously for approximately 10 min in a self-paced reaction task under conditions of both caffeine (250 mg) and placebo. The ERP data revealed more positive frontal P2 and parietal P3 components in the caffeine condition. However, a combination of different indices of the behavioral data did not reveal any effects of caffeine intake. These results suggest that caffeine increases arousal, thereby reducing fatigue, as was observed in the ERP results. A probable explanation for the absence of any effects of caffeine in the behavioral data can be found in the demanding properties of the task that was used, thereby supporting evidence for more pronounced effects of caffeine in suboptimal conditions. In addition, these results appeal for an increase in the use of ERPs in drug research, in order to discover possible effects on the brain which do not necessarily result in behavioral changes.

Multi-class ERP-based BCI data analysis using a discriminant space self-organizing map.

PubMed

Onishi, Akinari; Natsume, Kiyohisa

2014-01-01

Emotional or non-emotional image stimulus is recently applied to event-related potential (ERP) based brain computer interfaces (BCI). Though the classification performance is over 80% in a single trial, a discrimination between those ERPs has not been considered. In this research we tried to clarify the discriminability of four-class ERP-based BCI target data elicited by desk, seal, spider images and letter intensifications. A conventional self organizing map (SOM) and newly proposed discriminant space SOM (ds-SOM) were applied, then the discriminabilites were visualized. We also classify all pairs of those ERPs by stepwise linear discriminant analysis (SWLDA) and verify the visualization of discriminabilities. As a result, the ds-SOM showed understandable visualization of the data with a shorter computational time than the traditional SOM. We also confirmed the clear boundary between the letter cluster and the other clusters. The result was coherent with the classification performances by SWLDA. The method might be helpful not only for developing a new BCI paradigm, but also for the big data analysis.

Lexical Planning in Sentence Production Is Highly Incremental: Evidence from ERPs.

PubMed

Zhao, Li-Ming; Yang, Yu-Fang

2016-01-01

The scope of lexical planning, which means how far ahead speakers plan lexically before they start producing an utterance, is an important issue for research into speech production, but remains highly controversial. The present research investigated this issue using the semantic blocking effect, which refers to the widely observed effects that participants take longer to say aloud the names of items in pictures when the pictures in a block of trials in an experiment depict items that belong to the same semantic category than different categories. As this effect is often interpreted as a reflection of difficulty in lexical selection, the current study took the semantic blocking effect and its associated pattern of event-related brain potentials (ERPs) as a proxy to test whether lexical planning during sentence production extends beyond the first noun when a subject noun-phrase includes two nouns, such as "The chair and the boat are both red" and "The chair above the boat is red". The results showed a semantic blocking effect both in onset latencies and in ERPs during the utterance of the first noun of these complex noun-phrases but not for the second noun. The indication, therefore, is that the lexical planning scope does not encompass this second noun-phrase. Indeed, the present findings are in line with accounts that propose radically incremental lexical planning, in which speakers plan ahead only one word at a time. This study also provides a highly novel example of using ERPs to examine the production of long utterances, and it is hoped the present demonstration of the effectiveness of this approach inspires further application of ERP techniques in this area of research.

Event-related brain potentials and the study of reward processing: Methodological considerations.

PubMed

Krigolson, Olave E

2017-11-14

There is growing interest in using electroencephalography and specifically the event-related brain potential (ERP) methodology to study human reward processing. Since the discovery of the feedback related negativity (Miltner et al., 1997) and the development of theories associating the feedback related negativity and more recently the reward positivity with reinforcement learning, midbrain dopamine function, and the anterior cingulate cortex (i.e., Holroyd and Coles, 2002) researchers have used the ERP methodology to probe the neural basis of reward learning in humans. However, examination of the feedback related negativity and the reward positivity cannot be done without an understanding of some key methodological issues that must be taken into account when using ERPs and examining these ERP components. For example, even the component name - the feedback related negativity - is a source of debate within the research community as some now strongly feel that the component should be named the reward positivity (Proudfit, 2015). Here, ten key methodological issues are discussed - confusion in component naming, the reward positivity, component identification, peak quantification and the use of difference waveforms, frequency (the N200) and component contamination (the P300), the impact of feedback timing, action, and task learnability, and how learning results in changes in the amplitude of the feedback-related negativity/reward positivity. The hope here is to not provide a definitive approach for examining the feedback related negativity/reward positivity, but instead to outline the key issues that must be taken into account when examining this component to assist researchers in their study of human reward processing with the ERP methodology. Copyright © 2017 Elsevier B.V. All rights reserved.

N400 Deficits from Semantic Matching of Pictures in Probands and First-Degree Relatives from Multiplex Schizophrenia Families

ERIC Educational Resources Information Center

Guerra, Seidel; Ibanez, Agustin; Martin, Migdyrai; Bobes, Maria Antonieta; Reyes, Adnelys; Mendoza, Raul; Bravo, Tania; Dominguez, Mayelin; Sosa, Mitchell Valdes

2009-01-01

Endophenotypes is one emerging strategy in schizophrenia research that is being used to identify the functional importance of genetically transmitted, brain-based deficits present in this disease. Currently, event-related potentials (ERPs) are timely used in this search. Several ERPs, including N400, present deficits in relation to schizophrenia.…

Executive Function Effects and Numerical Development in Children: Behavioural and ERP Evidence from a Numerical Stroop Paradigm

ERIC Educational Resources Information Center

Soltesz, Fruzsina; Goswami, Usha; White, Sonia; Szucs, Denes

2011-01-01

Most research on numerical development in children is behavioural, focusing on accuracy and response time in different problem formats. However, Temple and Posner (1998) used ERPs and the numerical distance task with 5-year-olds to show that the development of numerical representations is difficult to disentangle from the development of the…

The Processing of Consonants and Vowels during Letter Identity and Letter Position Assignment in Visual-Word Recognition: An ERP Study

ERIC Educational Resources Information Center

Vergara-Martinez, Marta; Perea, Manuel; Marin, Alejandro; Carreiras, Manuel

2011-01-01

Recent research suggests that there is a processing distinction between consonants and vowels in visual-word recognition. Here we conjointly examine the time course of consonants and vowels in processes of letter identity and letter position assignment. Event related potentials (ERPs) were recorded while participants read words and pseudowords in…

Investigation of Effects of Face Rotation on Race Processing: An ERPs Study

ERIC Educational Resources Information Center

Montalan, Benoit; Veujoz, Mathieu; Boitout, Alexis; Leleu, Arnaud; Camus, Odile; Lalonde, Robert; Rebai, Mohamed

2013-01-01

Recent ERP research has indicated that the processing of faces of other races (OR) and same race (SR) as the perceiver differs at the perceptual level, more precisely for the N170 component. The purpose of the present study was to continue the investigation of the race-of-face processing across multiple orientations. Event-related brain potentials…

Brain Responses to Contrastive and Noncontrastive Morphosyntactic Structures in African American English and Mainstream American English: ERP Evidence for the Neural Indices of Dialect

ERIC Educational Resources Information Center

Garcia, Felicidad M.

2017-01-01

Recent research has shown that distinct event-related potential (ERP) signatures are associated with switching between languages compared to switching between dialects or registers (e.g., Khamis-Dakwar & Froud, 2007; Moreno, Federmeier & Kutas, 2002). The current investigation builds on these findings to examine whether contrastive and…

Temporal Dynamics of Late Second Language Acquisition: Evidence from Event-Related Brain Potentials

ERIC Educational Resources Information Center

Steinhauer, Karsten; White, Erin J.; Drury, John E.

2009-01-01

The ways in which age of acquisition (AoA) may affect (morpho)syntax in second language acquisition (SLA) are discussed. We suggest that event-related brain potentials (ERPs) provide an appropriate online measure to test some such effects. ERP findings of the past decade are reviewed with a focus on recent and ongoing research. It is concluded…

Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes Over Time

PubMed Central

Ghosh Hajra, Sujoy; Liu, Careesa C.; Song, Xiaowei; Fickling, Shaun; Liu, Luke E.; Pawlowski, Gabriela; Jorgensen, Janelle K.; Smith, Aynsley M.; Schnaider-Beeri, Michal; Van Den Broek, Rudi; Rizzotti, Rowena; Fisher, Kirk; D'Arcy, Ryan C. N.

2016-01-01

Clinical assessment of brain function relies heavily on indirect behavior-based tests. Unfortunately, behavior-based assessments are subjective and therefore susceptible to several confounding factors. Event-related brain potentials (ERPs), derived from electroencephalography (EEG), are often used to provide objective, physiological measures of brain function. Historically, ERPs have been characterized extensively within research settings, with limited but growing clinical applications. Over the past 20 years, we have developed clinical ERP applications for the evaluation of functional status following serious injury and/or disease. This work has identified an important gap: the need for a clinically accessible framework to evaluate ERP measures. Crucially, this enables baseline measures before brain dysfunction occurs, and might enable the routine collection of brain function metrics in the future much like blood pressure measures today. Here, we propose such a framework for extracting specific ERPs as potential “brain vital signs.” This framework enabled the translation/transformation of complex ERP data into accessible metrics of brain function for wider clinical utilization. To formalize the framework, three essential ERPs were selected as initial indicators: (1) the auditory N100 (Auditory sensation); (2) the auditory oddball P300 (Basic attention); and (3) the auditory speech processing N400 (Cognitive processing). First step validation was conducted on healthy younger and older adults (age range: 22–82 years). Results confirmed specific ERPs at the individual level (86.81–98.96%), verified predictable age-related differences (P300 latency delays in older adults, p < 0.05), and demonstrated successful linear transformation into the proposed brain vital sign (BVS) framework (basic attention latency sub-component of BVS framework reflects delays in older adults, p < 0.05). The findings represent an initial critical step in developing, extracting, and characterizing ERPs as vital signs, critical for subsequent evaluation of dysfunction in conditions like concussion and/or dementia. PMID:27242415

Computers-for-edu: An Advanced Business Application Programming (ABAP) Teaching Case

ERIC Educational Resources Information Center

Boyle, Todd A.

2007-01-01

The "Computers-for-edu" case is designed to provide students with hands-on exposure to creating Advanced Business Application Programming (ABAP) reports and dialogue programs, as well as navigating various mySAP Enterprise Resource Planning (ERP) transactions needed by ABAP developers. The case requires students to apply a wide variety…

Static renewal tests using Anodonta imbecillis (freshwater mussels). Anodonta imbecillis QA test 3, Clinch River-Environmental Restoration Program (CR-ERP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1994-12-31

Toxicity testing of split whole sediment samples using juvenile freshwater mussels (Anodonta imbecillis) was conducted by TVA to provide a quality assurance mechanism for test organism quality and overall performance of the test being conducted by CR-ERP personnel as part of the CR-ERP biomonitoring study of Clinch River sediments. Testing of sediment samples collected May 5 from Poplar Creek Miles 6.0 and 2.9 was conducted from May 10--19, 1994. Results from this test showed no toxicity (survival effects) to fresh-water mussels during a 9-day exposure to the sediments. Attachments to this report include: Chain of custody form -- original; Toxicitymore » test bench sheets; Ammonia analysis request and results; Meter calibration log sheets; and Training documentation forms.« less

Static renewal tests using Anodonta imbecillis (freshwater mussels). Anodonta imbecillis QA test 2, Clinch River-Environmental Restoration Program (CR-ERP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1993-12-31

Toxicity testing of split whole sediment samples using juvenile freshwater mussels (Anodonta imbecillis) was conducted by TVA to provide a quality assurance mechanism for test organism quality and overall performance of the test being conducted by CR-ERP personnel as part of the CR-ERP biomonitoring study of Clinch River sediments. Testing of sediment samples collected August 14 from Poplar Creek Miles 6.0 and 4.3 was conducted from August 24--September 2, 1993. Results from this test showed no toxicity (survival effects) to fresh-water mussels during a 9-day exposure to the sediments. Attachments to this report include: Chain of custody form -- original;more » Toxicity test bench sheets and statistical analyses; and Ammonia analysis request and results.« less

Effect of EEG Referencing Methods on Auditory Mismatch Negativity

PubMed Central

Mahajan, Yatin; Peter, Varghese; Sharma, Mridula

2017-01-01

Auditory event-related potentials (ERPs) have consistently been used in the investigation of auditory and cognitive processing in the research and clinical laboratories. There is currently no consensus on the choice of appropriate reference for auditory ERPs. The most commonly used references in auditory ERP research are the mathematically linked-mastoids (LM) and average referencing (AVG). Since LM and AVG referencing procedures do not solve the issue of electrically-neutral reference, Reference Electrode Standardization Technique (REST) was developed to create a neutral reference for EEG recordings. The aim of the current research is to compare the influence of the reference on amplitude and latency of auditory mismatch negativity (MMN) as a function of magnitude of frequency deviance across three commonly used electrode montages (16, 32, and 64-channel) using REST, LM, and AVG reference procedures. The current study was designed to determine if the three reference methods capture the variation in amplitude and latency of MMN with the deviance magnitude. We recorded MMN from 12 normal hearing young adults in an auditory oddball paradigm with 1,000 Hz pure tone as standard and 1,030, 1,100, and 1,200 Hz as small, medium and large frequency deviants, respectively. The EEG data recorded to these sounds was re-referenced using REST, LM, and AVG methods across 16-, 32-, and 64-channel EEG electrode montages. Results revealed that while the latency of MMN decreased with increment in frequency of deviant sounds, no effect of frequency deviance was present for amplitude of MMN. There was no effect of referencing procedure on the experimental effect tested. The amplitude of MMN was largest when the ERP was computed using LM referencing and the REST referencing produced the largest amplitude of MMN for 64-channel montage. There was no effect of electrode-montage on AVG referencing induced ERPs. Contrary to our predictions, the results suggest that the auditory MMN elicited as a function of increments in frequency deviance does not depend on the choice of referencing procedure. The results also suggest that auditory ERPs generated using REST referencing is contingent on the electrode arrays more than the AVG referencing. PMID:29066945

Inhibitory control gains from higher-order cognitive strategy training.

PubMed

Motes, Michael A; Gamino, Jacquelyn F; Chapman, Sandra B; Rao, Neena K; Maguire, Mandy J; Brier, Matthew R; Kraut, Michael A; Hart, John

2014-02-01

The present study examined the transfer of higher-order cognitive strategy training to inhibitory control. Middle school students enrolled in a comprehension- and reasoning-focused cognitive strategy training program and passive controls participated. The training program taught students a set of steps for inferring essential gist or themes from materials. Both before and after training or a comparable duration in the case of the passive controls, participants completed a semantically cued Go/No-Go task that was designed to assess the effects of depth of semantic processing on response inhibition and components of event-related potentials (ERP) related to response inhibition. Depth of semantic processing was manipulated by varying the level of semantic categorization required for response selection and inhibition. The SMART-trained group showed inhibitory control gains and changes in fronto-central P3 ERP amplitudes on inhibition trials; whereas, the control group did not. The results provide evidence of the transfer of higher-order cognitive strategy training to inhibitory control and modulation of ERPs associated with semantically cued inhibitory control. The findings are discussed in terms of implications for cognitive strategy training, models of cognitive abilities, and education. Published by Elsevier Inc.

Clinch River - Environmental Restoration Program (CR-ERP) study, ambient water toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1997-06-01

Clinch River - Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a study during the week of April 14-21, 1994, as described in the Statement of Work (SOW) document. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Surface water samples were collected by TVA Field Engineering personnel from Poplar Creek Mile 4.3, Poplar Creek Mile 5.1, and Poplar Creek Mile 6.0 on April 13, 15, and 18. Samples were partitioned (split) and provided to the CR-ERP and TVA toxicology laboratories for testing. Exposure of test organisms to thesemore » samples resulted in no toxicity (survival or growth) to daphnids in undiluted samples; however, toxicity to fathead minnows (significantly reduced survival) was demonstrated in undiluted samples from Poplar Creek Miles 4.3 and 6.0 in testing conducted by TVA based on hypothesis testing of data. Daphnid reproduction was significantly less than controls in 50 percent dilutions of samples from Poplar Creek Miles 4.3 and 6.0, while no toxicity to fathead minnows was shown in diluted (50 percent) samples.« less

An app for patient education and self-audit within an enhanced recovery program for bowel surgery: a pilot study assessing validity and usability.

PubMed

Pecorelli, Nicolò; Fiore, Julio F; Kaneva, Pepa; Somasundram, Abarna; Charlebois, Patrick; Liberman, A Sender; Stein, Barry L; Carli, Franco; Feldman, Liane S

2018-05-01

While patient engagement and clinical audit are key components of successful enhanced recovery programs (ERPs), they require substantial resource allocation. The objective of this study was to assess the validity and usability of a novel mobile device application for education and self-reporting of adherence for patients undergoing bowel surgery within an established ERP. Prospectively recruited patients undergoing bowel surgery within an ERP used a novel app specifically designed to provide daily recovery milestones and record adherence to 15 different ERP processes and six patient-reported outcomes (PROs). Validity was measured by the agreement index (Cohen's kappa coefficient for categorical, and interclass correlation coefficient (ICC) for continuous variables) between patient-reported data through the app and data recorded by a clinical auditor. Acceptability and usability of the app were measured by the System Usability Scale (SUS). Forty-five patients participated in the study (mean age 61, 64% male). Overall, patients completed 159 of 179 (89%) of the available questionnaires through the app. Median time to complete a questionnaire was 2 min 49 s (i.q.r. 2'32″-4'36″). Substantial (kappa > 0.6) or almost perfect agreement (kappa > 0.8) and strong correlation (ICC > 0.7) between data collected through the app and by the clinical auditor was found for 14 ERP processes and four PROs. Patient-reported usability was high; mean SUS score was 87 (95% CI 83-91). Only 6 (13%) patients needed technical support to use the app. Forty (89%) patients found the app was helpful to achieve their daily goals, and 34 (76%) thought it increased their motivation to recover after surgery. This novel application provides a tool to record patient adherence to care processes and PROs, with high agreement with traditional clinical audit, high usability, and patient satisfaction. Future studies should investigate the use of mobile device apps as strategies to increase adherence to perioperative interventions.

Teasing apart the anticipatory and consummatory processing of monetary incentives: An event-related potential study of reward dynamics.

PubMed

Novak, Keisha D; Foti, Dan

2015-11-01

The monetary incentive delay (MID) task has been widely used in fMRI studies to investigate the neural networks involved in anticipatory and consummatory reward processing. Previous efforts to adapt the MID task for use with ERPs, however, have had limited success. Here, we sought to further decompose reward dynamics using a comprehensive set of anticipatory (cue-N2, cue-P3, contingent negative variation [CNV]) and consummatory ERPs (feedback negativity [FN], feedback P3 [fb-P3]). ERP data was recorded during adapted versions of the MID task across two experiments. Unlike previous studies, monetary incentive cues modulated the cue-N2, cue-P3, and CNV; however, cue-related ERPs and the CNV were uncorrelated with one another, indicating distinct anticipatory subprocesses. With regard to consummatory processing, FN amplitude primarily tracked outcome valence (reward vs. nonreward), whereas fb-P3 amplitude primarily tracked outcome salience (uncertain vs. certain). Independent modulation of the cue-P3 and fb-P3 was observed, indicating that these two P3 responses may uniquely capture the allocation of attention during anticipatory and consummatory reward processing, respectively. Overall, across two samples, consistent evidence of both anticipatory and consummatory ERP activity was observed on an adapted version of the MID paradigm, demonstrating for the first time how these ERP components may be integrated with one another to more fully characterize the time course of reward processing. This ERP-MID paradigm is well suited to parsing reward dynamics, and can be applied to both healthy and clinical populations. © 2015 Society for Psychophysiological Research.

Distinguishing Neurocognitive Processes Reflected by P600 Effects: Evidence from ERPs and Neural Oscillations

PubMed Central

Regel, Stefanie; Meyer, Lars; Gunter, Thomas C.

2014-01-01

Research on language comprehension using event-related potentials (ERPs) reported distinct ERP components reliably related to the processing of semantic (N400) and syntactic information (P600). Recent ERP studies have challenged this well-defined distinction by showing P600 effects for semantic and pragmatic anomalies. So far, it is still unresolved whether the P600 reflects specific or rather common processes. The present study addresses this question by investigating ERPs in response to a syntactic and pragmatic (irony) manipulation, as well as a combined syntactic and pragmatic manipulation. For the syntactic condition, a morphosyntactic violation was applied, whereas for the pragmatic condition, such as “That is rich”, either an ironic or literal interpretation was achieved, depending on the prior context. The ERPs at the critical word showed a LAN-P600 pattern for syntactically incorrect sentences relative to correct ones. For ironic compared to literal sentences, ERPs showed a P200 effect followed by a P600 component. In comparison of the syntax-related P600 to the irony-related P600, distributional differences were found. Moreover, for the P600 time window (i.e., 500–900 ms), different changes in theta power between the syntax and pragmatics effects were found, suggesting that different patterns of neural activity contributed to each respective effect. Thus, both late positivities seem to be differently sensitive to these two types of linguistic information, and might reflect distinct neurocognitive processes, such as reanalysis of the sentence structure versus pragmatic reanalysis. PMID:24844290

The Effects of Face Inversion and Face Race on the P100 ERP.

PubMed

Colombatto, Clara; McCarthy, Gregory

2017-04-01

Research about the neural basis of face recognition has investigated the timing and anatomical substrates of different stages of face processing. Scalp-recorded ERP studies of face processing have focused on the N170, an ERP with a peak latency of ∼170 msec that has long been associated with the initial structural encoding of faces. However, several studies have reported earlier ERP differences related to faces, suggesting that face-specific processes might occur before N170. Here, we examined the influence of face inversion and face race on the timing of face-sensitive scalp-recorded ERPs by examining neural responses to upright and inverted line-drawn and luminance-matched white and black faces in a sample of white participants. We found that the P100 ERP evoked by inverted faces was significantly larger than that evoked by upright faces. Although this inversion effect was statistically significant at 100 msec, the inverted-upright ERP difference peaked at 138 msec, suggesting that it might represent an activity in neural sources that overlap with P100. Inverse modeling of the inversion effect difference waveform suggested possible neural sources in pericalcarine extrastriate visual cortex and lateral occipito-temporal cortex. We also found that the inversion effect difference wave was larger for white faces. These results are consistent with behavioral evidence that individuals process the faces of their own races more configurally than faces of other races. Taken together, the inversion and race effects observed in the current study suggest that configuration influences face processing by at least 100 msec.

The roles of protein disulphide isomerase family A, member 3 (ERp57) and surface thiol/disulphide exchange in human spermatozoa-zona pellucida binding.

PubMed

Wong, Chi-Wai; Lam, Kevin K W; Lee, Cheuk-Lun; Yeung, William S B; Zhao, Wei E; Ho, Pak-Chung; Ou, Jian-Ping; Chiu, Philip C N

2017-04-01

Are multimeric sperm plasma membrane protein complexes, ERp57 and sperm surface thiol content involved in human spermatozoa-zona pellucida (ZP) interaction? ERp57 is a component of a multimeric spermatozoa-ZP receptor complex involved in regulation of human spermatozoa-ZP binding via up-regulation of sperm surface thiol content. A spermatozoon acquires its fertilization capacity within the female reproductive tract by capacitation. Spermatozoa-ZP receptor is suggested to be a composite structure that is assembled into a functional complex during capacitation. Sperm surface thiol content is elevated during capacitation. ERp57 is a protein disulphide isomerase that modulates the thiol-disulphide status of proteins. The binding ability and components of protein complexes in extracted membrane protein fractions of spermatozoa were studied. The roles of capacitation, thiol-disulphide reagent treatments and ERp57 on sperm functions and sperm surface thiol content were assessed. Spermatozoa were obtained from semen samples from normozoospermic men. Human oocytes were obtained from an assisted reproduction programme. Blue native polyacrylamide gel electrophoresis, western ligand blotting and mass spectrometry were used to identify the components of solubilized ZP/ZP3-binding complexes. The localization and expression of sperm surface thiol and ERp57 were studied by immunostaining and sperm surface protein biotinylation followed by western blotting. Sperm functions were assessed by standard assays. Several ZP-binding complexes were isolated from the cell membrane of capacitated spermatozoa. ERp57 was a component of one of these complexes. Capacitation significantly increased the sperm surface thiol content, acrosomal thiol distribution and ERp57 expression on sperm surface. Sperm surface thiol and ERp57 immunoreactivity were localized to the acrosomal region of spermatozoa, a region responsible for ZP-binding. Up-regulation of the surface thiol content or ERp57 surface expression in vitro stimulated ZP-binding capacity of human spermatozoa. Blocking of ERp57 function by specific antibody or inhibitors against ERp57 reduced the surface thiol content and ZP-binding capacity of human spermatozoa. N/A. The mechanisms by which up-regulation of surface thiol content stimulates spermatozoa-ZP binding have not been depicted. Thiol-disulphide exchange is a crucial event in capacitation. ERp57 modulates the event and the subsequent fertilization process. Modulation of the surface thiol content of the spermatozoa of subfertile men may help to increase fertilization rate in assisted reproduction. This work was supported by The Hong Kong Research Grant Council Grant HKU764611 and HKU764512M to P.C.N.C. The authors have no competing interests. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

A Strategy for Combining the Pollution Prevention Opportunity Assessment with the Environmental Compliance Assessment and Management Program

DTIC Science & Technology

1993-09-01

reductions occur, all government agencies will be faced with a need to streamline their programs and reduce their program implemetation and compliance costs. A...IRP) 14. Does the insta~lation cunuvtly have any designated IRP sites? IS. If ERP sites am preent, does the installanion maintain documentation of

Brain Plasticity in Speech Training in Native English Speakers Learning Mandarin Tones

NASA Astrophysics Data System (ADS)

Heinzen, Christina Carolyn

The current study employed behavioral and event-related potential (ERP) measures to investigate brain plasticity associated with second-language (L2) phonetic learning based on an adaptive computer training program. The program utilized the acoustic characteristics of Infant-Directed Speech (IDS) to train monolingual American English-speaking listeners to perceive Mandarin lexical tones. Behavioral identification and discrimination tasks were conducted using naturally recorded speech, carefully controlled synthetic speech, and non-speech control stimuli. The ERP experiments were conducted with selected synthetic speech stimuli in a passive listening oddball paradigm. Identical pre- and post- tests were administered on nine adult listeners, who completed two-to-three hours of perceptual training. The perceptual training sessions used pair-wise lexical tone identification, and progressed through seven levels of difficulty for each tone pair. The levels of difficulty included progression in speaker variability from one to four speakers and progression through four levels of acoustic exaggeration of duration, pitch range, and pitch contour. Behavioral results for the natural speech stimuli revealed significant training-induced improvement in identification of Tones 1, 3, and 4. Improvements in identification of Tone 4 generalized to novel stimuli as well. Additionally, comparison between discrimination of across-category and within-category stimulus pairs taken from a synthetic continuum revealed a training-induced shift toward more native-like categorical perception of the Mandarin lexical tones. Analysis of the Mismatch Negativity (MMN) responses in the ERP data revealed increased amplitude and decreased latency for pre-attentive processing of across-category discrimination as a result of training. There were also laterality changes in the MMN responses to the non-speech control stimuli, which could reflect reallocation of brain resources in processing pitch patterns for the across-category lexical tone contrast. Overall, the results support the use of IDS characteristics in training non-native speech contrasts and provide impetus for further research.

Ecological Restoration Programs Induced Amelioration of the Dust Pollution in North China Plain

NASA Astrophysics Data System (ADS)

Long, X.; Tie, X.; Li, G.; Junji, C.

2017-12-01

With Moderate Resolution Imaging Spectroradiometer (MODIS) land cover product (MCD12Q1), we quantitatively evaluate the ecological restoration programs (ERP) induced land cover change in China by calculating gridded the land use fraction (LUF). We clearly capture two obvious vegetation (grass and forest) protective barriers arise between the dust source region DSR and North China Plain NCP from 2011 to 2013. The WRF-DUST model is applied to investigate the impact of ERPs on dust pollution from 2 to 8 March 2016, corresponding to a national dust storm event over China. Despite some model biases, the WRF-DUST model reasonably reproduced the temporal variations of dust storm event, involving IOA of 0.96 and NMB of 2% for DSR, with IOA of 0.83 and NMB of -15% for downwind area of NCP. Generally, the WRF-DUST model well capture the spatial variations and evolutions of dust storm events with episode-average [PMC] correlation coefficient (R) of 0.77, especially the dust storm outbreak and transport evolution, involving daily average [PMC] R of 0.9 and 0.73 on 4-5 March, respectively. It is found that the ERPs generally reduce the dust pollution in NCP, especially for BTH, involving upper dust pollution control benefits of -15.3% (-21.0 μg m-3) for BTH, and -6.2% (-9.3 μg m-3) for NCP. We are the first to conduct model sensitivity studies to quantitatively evaluate the impacts of the ERPs on the dust pollution in NCP. And our narrative is independently based on first-hand sources, whereas government statistics.

Prediction during language comprehension: benefits, costs, and ERP components.

PubMed

Van Petten, Cyma; Luka, Barbara J

2012-02-01

Because context has a robust influence on the processing of subsequent words, the idea that readers and listeners predict upcoming words has attracted research attention, but prediction has fallen in and out of favor as a likely factor in normal comprehension. We note that the common sense of this word includes both benefits for confirmed predictions and costs for disconfirmed predictions. The N400 component of the event-related potential (ERP) reliably indexes the benefits of semantic context. Evidence that the N400 is sensitive to the other half of prediction--a cost for failure--is largely absent from the literature. This raises the possibility that "prediction" is not a good description of what comprehenders do. However, it need not be the case that the benefits and costs of prediction are evident in a single ERP component. Research outside of language processing indicates that late positive components of the ERP are very sensitive to disconfirmed predictions. We review late positive components elicited by words that are potentially more or less predictable from preceding sentence context. This survey suggests that late positive responses to unexpected words are fairly common, but that these consist of two distinct components with different scalp topographies, one associated with semantically incongruent words and one associated with congruent words. We conclude with a discussion of the possible cognitive correlates of these distinct late positivities and their relationships with more thoroughly characterized ERP components, namely the P300, P600 response to syntactic errors, and the "old/new effect" in studies of recognition memory. Copyright © 2011 Elsevier B.V. All rights reserved.

Mindfulness training for adolescents: A neurodevelopmental perspective on investigating modifications in attention and emotion regulation using event-related brain potentials.

PubMed

Sanger, Kevanne Louise; Dorjee, Dusana

2015-09-01

Mindfulness training is increasingly being introduced in schools, yet studies examining its impact on the developing brain have been scarce. A neurodevelopmental perspective on mindfulness has been advocated as a powerful tool to enhance our understanding of underlying neurocognitive changes that have implications for developmental well-being research and the implementation of mindfulness in education. To stimulate more research in the developmental cognitive neuroscience of mindfulness, this article outlines possible indexes of mindfulness-based change in adolescence, with a focus on event-related brain potential (ERP) markers. We provide methodological recommendations for future studies and offer examples of research paradigms. We also discuss how mindfulness practice could impact on the development of prefrontal brain structures and enhance attention control and emotion regulation skills in adolescents, impacting in turn on their self-regulation and coping skills. We highlight advantages of the ERP methodology in neurodevelopmental research of mindfulness. It is proposed that research using established experimental tasks targeting ERP components such as the contingent negative variability, N200, error-related negativity and error positivity, P300, and late positive potential could elucidate developmentally salient shifts in the neural plasticity of the adolescent brain induced by mindfulness practice.

How personal earthquake experience impacts on the Stroop interference effect: an event-related potential study.

PubMed

Qiu, Jiang; Su, Yanhua; Li, Hong; Wei, Dongtao; Tu, Shen; Zhang, Qinglin

2010-11-01

Event-related brain potentials (ERPs) were measured when 24 Chinese subjects performed the classical Stroop task. All of subjects had experienced the great Sichuan earthquake (5/12), with 12 people in each of the Far (Chengdu city) and the Close (Deyang city) earthquake experience groups. The behavioral data showed that the Stroop task yielded a robust Stroop interference effect as indexed by longer RT for incongruent than congruent color words in both the Chengdu and Deyang groups. Scalp ERP data showed that incongruent stimuli elicited a more negative ERP deflection (N400-600; Stroop interference effect) than did congruent stimuli between 400-600 ms in the Chengdu group, while the Stroop interference ERP effect was not found in the Deyang group. Dipole source analysis localized the generator of the N400-600 in the right prefrontal cortex (PFC) and was possibly related to conflict monitoring and cognitive control. Copyright © 2010 Society for Psychophysiological Research.

The disulfide isomerase ERp57 is required for fibrin deposition in vivo.

PubMed

Zhou, J; Wu, Y; Wang, L; Rauova, L; Hayes, V M; Poncz, M; Essex, D W

2014-11-01

ERp57 is required for platelet function; however, whether ERp57 contributes to fibrin generation is unknown. Using an inhibitory anti-ERp57 antibody (mAb1), Pf4-Cre/ERp57(fl/fl) mice, Tie2-Cre/ERp57(fl/fl) mice, and mutants of ERp57, we analyzed the function of ERp57 in laser-induced thrombosis. Fibrin deposition was decreased in Pf4-Cre/ERp57(fl/fl) mice, consistent with a role for platelet ERp57 in fibrin generation. Fibrin deposition was further decreased with infusion of mAb1 and in Tie2-Cre/ERp57(fl/fl) mice, consistent with endothelial cells also contributing to fibrin deposition. Infusion of eptibifatide inhibited platelet and fibrin deposition, confirming a role for platelets in fibrin deposition. Infusion of recombinant ERp57 corrected the defect in fibrin deposition but not platelet accumulation, suggesting a direct effect of ERp57 on coagulation. mAb1 inhibited thrombin generation in vitro, consistent with a requirement for ERp57 in coagulation. Platelet accumulation was decreased to similar extents in Pf4-Cre/ERp57(fl/fl) mice, Tie2-Cre/ERp57(fl/fl) mice and normal mice infused with mAb1. Infusion of completely inactivated ERp57 or ERp57 with a non-functional second active site inhibited fibrin deposition and platelet accumulation, indicating that the isomerase activity of the second active site is required for these processes. ERp57 regulates thrombosis via multiple targets. © 2014 International Society on Thrombosis and Haemostasis.

Electrophysiological Responses to Expectancy Violations in Semantic and Gambling Tasks: A Comparison of Different EEG Reference Approaches

PubMed Central

Li, Ya; Wang, Yongchun; Zhang, Baoqiang; Wang, Yonghui; Zhou, Xiaolin

2018-01-01

Dynamically evaluating the outcomes of our actions and thoughts is a fundamental cognitive ability. Given its excellent temporal resolution, the event-related potential (ERP) technology has been used to address this issue. The feedback-related negativity (FRN) component of ERPs has been studied intensively with the averaged linked mastoid reference method (LM). However, it is unknown whether FRN can be induced by an expectancy violation in an antonym relations context and whether LM is the most suitable reference approach. To address these issues, the current research directly compared the ERP components induced by expectancy violations in antonym expectation and gambling tasks with a within-subjects design and investigated the effect of the reference approach on the experimental effects. Specifically, we systematically compared the influence of the LM, reference electrode standardization technique (REST) and average reference (AVE) approaches on the amplitude, scalp distribution and magnitude of ERP effects as a function of expectancy violation type. The expectancy deviation in the antonym expectation task elicited an N400 effect that differed from the FRN effect induced in the gambling task; this difference was confirmed by all the three reference methods. Both the amplitudes of the ERP effects (N400 and FRN) and the magnitude as the expectancy violation increased were greater under the LM approach than those under the REST approach, followed by those under the AVE approach. Based on the statistical results, the electrode sites that showed the N400 and FRN effects critically depended on the reference method, and the results of the REST analysis were consistent with previous ERP studies. Combined with evidence from simulation studies, we suggest that REST is an optional reference method to be used in future ERP data analysis. PMID:29615858

Data of ERPs and spectral alpha power when attention is engaged on visual or verbal/auditory imagery

PubMed Central

Villena-González, Mario; López, Vladimir; Rodríguez, Eugenio

2016-01-01

This article provides data from statistical analysis of event-related brain potentials (ERPs) and spectral power from 20 participants during three attentional conditions. Specifically, P1, N1 and P300 amplitude of ERP were compared when participant׳s attention was oriented to an external task, to a visual imagery and to an inner speech. The spectral power from alpha band was also compared in these three attentional conditions. These data are related to the research article where sensory processing of external information was compared during these three conditions entitled “Orienting attention to visual or verbal/auditory imagery differentially impairs the processing of visual stimuli” (Villena-Gonzalez et al., 2016) [1]. PMID:27077090

Crystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H.

PubMed

Brangulis, Kalvis; Petrovskis, Ivars; Kazaks, Andris; Akopjana, Inara; Tars, Kaspars

2015-05-01

Borrelia burgdorferi is the causative agent of Lyme disease, which can be acquired after the bite of an infected Ixodes tick. As a strategy to resist the innate immunity and to successfully spread and proliferate, B. burgdorferi expresses a set of outer membrane proteins that are capable of binding complement regulator factor H (CFH), factor H-like protein 1 (CFHL-1) and factor H-related proteins (CFHR) to avoid complement-mediated killing. B. burgdorferi B31 contains three proteins that belong to the Erp (OspE/F-related) protein family and are capable of binding CFH and some CFHRs, namely ErpA, ErpC and ErpP. We have determined the crystal structure of ErpP at 2.53Å resolution and the crystal structure of ErpC at 2.15Å resolution. Recently, the crystal structure of the Erp family member OspE from B. burgdorferi N40 was determined in complex with CFH domains 19-20, revealing the residues involved in the complex formation. Despite the high sequence conservation between ErpA, ErpC, ErpP and the homologous protein OspE (78-80%), the affinity for CFH and CFHRs differs markedly among the Erp family members, suggesting that ErpC may bind only CFHRs but not CFH. A comparison of the binding site in OspE with those of ErpC and ErpP revealed that the extended loop region, which is only observed in the potential binding site of ErpC, plays an important role by preventing the binding of CFH. These results can explain the inability of ErpC to bind CFH, whereas ErpP and ErpA still possess the ability to bind CFH. Copyright © 2015 Elsevier B.V. All rights reserved.

Within-subject joint independent component analysis of simultaneous fMRI/ERP in an auditory oddball paradigm

PubMed Central

MANGALATHU-ARUMANA, J.; BEARDSLEY, S. A.; LIEBENTHAL, E.

2012-01-01

The integration of event-related potential (ERP) and functional magnetic resonance imaging (fMRI) can contribute to characterizing neural networks with high temporal and spatial resolution. This research aimed to determine the sensitivity and limitations of applying joint independent component analysis (jICA) within-subjects, for ERP and fMRI data collected simultaneously in a parametric auditory frequency oddball paradigm. In a group of 20 subjects, an increase in ERP peak amplitude ranging 1–8 μV in the time window of the P300 (350–700ms), and a correlated increase in fMRI signal in a network of regions including the right superior temporal and supramarginal gyri, was observed with the increase in deviant frequency difference. JICA of the same ERP and fMRI group data revealed activity in a similar network, albeit with stronger amplitude and larger extent. In addition, activity in the left pre- and post- central gyri, likely associated with right hand somato-motor response, was observed only with the jICA approach. Within-subject, the jICA approach revealed significantly stronger and more extensive activity in the brain regions associated with the auditory P300 than the P300 linear regression analysis. The results suggest that with the incorporation of spatial and temporal information from both imaging modalities, jICA may be a more sensitive method for extracting common sources of activity between ERP and fMRI. PMID:22377443

Recording event-related activity under hostile magnetic resonance environment: Is multimodal EEG/ERP-MRI recording possible?

PubMed

Karakaş, H M; Karakaş, S; Ozkan Ceylan, A; Tali, E T

2009-08-01

Event-related potentials (ERPs) have high temporal resolution, but insufficient spatial resolution; the converse is true for the functional imaging techniques. The purpose of the study was to test the utility of a multimodal EEG/ERP-MRI technique which combines electroencephalography (EEG) and magnetic resonance imaging (MRI) for a simultaneously high temporal and spatial resolution. The sample consisted of 32 healthy young adults of both sexes. Auditory stimuli were delivered according to the active and passive oddball paradigms in the MRI environment (MRI-e) and in the standard conditions of the electrophysiology laboratory environment (Lab-e). Tasks were presented in a fixed order. Participants were exposed to the recording environments in a counterbalanced order. EEG data were preprocessed for MRI-related artifacts. Source localization was made using a current density reconstruction technique. The ERP waveforms for the MRI-e were morphologically similar to those for the Lab-e. The effect of the recording environment, experimental paradigm and electrode location were analyzed using a 2x2x3 analysis of variance for repeated measures. The ERP components in the two environments showed parametric variations and characteristic topographical distributions. The calculated sources were in line with the related literature. The findings indicated effortful cognitive processing in MRI-e. The study provided preliminary data on the feasibility of the multimodal EEG/ERP-MRI technique. It also indicated lines of research that are to be pursued for a decisive testing of this technique and its implementation to clinical practice.

Neural correlates of emotional intelligence in a visual emotional oddball task: an ERP study.

PubMed

Raz, Sivan; Dan, Orrie; Zysberg, Leehu

2014-11-01

The present study was aimed at identifying potential behavioral and neural correlates of Emotional Intelligence (EI) by using scalp-recorded Event-Related Potentials (ERPs). EI levels were defined according to both self-report questionnaire and a performance-based ability test. We identified ERP correlates of emotional processing by using a visual-emotional oddball paradigm, in which subjects were confronted with one frequent standard stimulus (a neutral face) and two deviant stimuli (a happy and an angry face). The effects of these faces were then compared across groups with low and high EI levels. The ERP results indicate that participants with high EI exhibited significantly greater mean amplitudes of the P1, P2, N2, and P3 ERP components in response to emotional and neutral faces, at frontal, posterior-parietal and occipital scalp locations. P1, P2 and N2 are considered indexes of attention-related processes and have been associated with early attention to emotional stimuli. The later P3 component has been thought to reflect more elaborative, top-down, emotional information processing including emotional evaluation and memory encoding and formation. These results may suggest greater recruitment of resources to process all emotional and non-emotional faces at early and late processing stages among individuals with higher EI. The present study underscores the usefulness of ERP methodology as a sensitive measure for the study of emotional stimuli processing in the research field of EI. Copyright © 2014 Elsevier Inc. All rights reserved.

Patient Characterization Protocols for Psychophysiological Studies of Traumatic Brain Injury and Post-TBI Psychiatric Disorders

DTIC Science & Technology

2013-07-22

injury and psychiatric disorders are receiving increased research attention, and ERP technologies are making contributions to this effort. This review has... technology like ERPs. They yield information not evi- dent in RT and allow us to fractionate the stimulus input-response output process with greater...Homaifar et al. (98), who writing specifically about depression following TBI, recommended that multiple means of assessment should be used when diagnosing

The interoperability force in the ERP field

NASA Astrophysics Data System (ADS)

Boza, Andrés; Cuenca, Llanos; Poler, Raúl; Michaelides, Zenon

2015-04-01

Enterprise resource planning (ERP) systems participate in interoperability projects and this participation sometimes leads to new proposals for the ERP field. The aim of this paper is to identify the role that interoperability plays in the evolution of ERP systems. To go about this, ERP systems have been first identified within interoperability frameworks. Second, the initiatives in the ERP field driven by interoperability requirements have been identified from two perspectives: technological and business. The ERP field is evolving from classical ERP as information system integrators to a new generation of fully interoperable ERP. Interoperability is changing the way of running business, and ERP systems are changing to adapt to the current stream of interoperability.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandt, C.C.; Benson, S.B.; Beeler, D.A.

The Clinch River Remedial Investigation (CRRI) is designed to address the transport, fate, and distribution of waterborne contaminants (radionuclides, metals, and organic compounds) released from the US Department of Energy`s (DOE`s) Oak Ridge Reservation (ORR) and to assess potential risks to human health and the environment associated with these contaminants. The remedial investigation is entering Phase 2, which has the following items as its objectives: define the nature and extent of the contamination in areas downstream from the DOE ORR, evaluate the human health and ecological risks posed by these contaminants, and perform preliminary identification and evaluation of potential remediationmore » alternatives. This plan describes the requirements, responsibilities, and roles of personnel during sampling, analysis, and data review for the Clinch River Environmental Restoration Program (CR-ERP). The purpose of the plan is to formalize the process for obtaining analytical services, tracking sampling and analysis documentation, and assessing the overall quality of the CR-ERP data collection program to ensure that it will provide the necessary building blocks for the program decision-making process.« less

Second Language Processing Shows Increased Native-Like Neural Responses after Months of No Exposure

PubMed Central

Morgan-Short, Kara; Finger, Ingrid; Grey, Sarah; Ullman, Michael T.

2012-01-01

Although learning a second language (L2) as an adult is notoriously difficult, research has shown that adults can indeed attain native language-like brain processing and high proficiency levels. However, it is important to then retain what has been attained, even in the absence of continued exposure to the L2—particularly since periods of minimal or no L2 exposure are common. This event-related potential (ERP) study of an artificial language tested performance and neural processing following a substantial period of no exposure. Adults learned to speak and comprehend the artificial language to high proficiency with either explicit, classroom-like, or implicit, immersion-like training, and then underwent several months of no exposure to the language. Surprisingly, proficiency did not decrease during this delay. Instead, it remained unchanged, and there was an increase in native-like neural processing of syntax, as evidenced by several ERP changes—including earlier, more reliable, and more left-lateralized anterior negativities, and more robust P600s, in response to word-order violations. Moreover, both the explicitly and implicitly trained groups showed increased native-like ERP patterns over the delay, indicating that such changes can hold independently of L2 training type. The results demonstrate that substantial periods with no L2 exposure are not necessarily detrimental. Rather, benefits may ensue from such periods of time even when there is no L2 exposure. Interestingly, both before and after the delay the implicitly trained group showed more native-like processing than the explicitly trained group, indicating that type of training also affects the attainment of native-like processing in the brain. Overall, the findings may be largely explained by a combination of forgetting and consolidation in declarative and procedural memory, on which L2 grammar learning appears to depend. The study has a range of implications, and suggests a research program with potentially important consequences for second language acquisition and related fields. PMID:22470434

Computer-Assisted Instruction in Early Literacy for African American, Economically Disadvantaged Children

ERIC Educational Resources Information Center

Shamir, Haya; Feehan, Kathryn; Yoder, Erik

2017-01-01

This study explores the efficacy of the Waterford Early Reading program (ERP) for teaching kindergarten and first grade students' early reading concepts. Students attended 3 elementary schools in Alabama. The treatment group used the software program whereas the control group did not use the software. Analyses revealed a significant treatment…

Chaotic time series analysis of vision evoked EEG

NASA Astrophysics Data System (ADS)

Zhang, Ningning; Wang, Hong

2010-01-01

To investigate the human brain activities for aesthetic processing, beautiful woman face picture and ugly buffoon face picture were applied. Twelve subjects were assigned the aesthetic processing task while the electroencephalogram (EEG) was recorded. Event-related brain potential (ERP) was required from the 32 scalp electrodes and the ugly buffoon picture produced larger amplitudes for the N1, P2, N2, and late slow wave components. Average ERP from the ugly buffoon picture were larger than that from the beautiful woman picture. The ERP signals shows that the ugly buffoon elite higher emotion waves than the beautiful woman face, because some expression is on the face of the buffoon. Then, chaos time series analysis was carried out to calculate the largest Lyapunov exponent using small data set method and the correlation dimension using G-P algorithm. The results show that the largest Lyapunov exponents of the ERP signals are greater than zero, which indicate that the ERP signals may be chaotic. The correlations dimensions coming from the beautiful woman picture are larger than that from the ugly buffoon picture. The comparison of the correlations dimensions shows that the beautiful face can excite the brain nerve cells. The research in the paper is a persuasive proof to the opinion that cerebrum's work is chaotic under some picture stimuli.

The Challenge of Implementing an ERP System in a Small and Medium Enterprise--A Teaching Case of ERP Project Management

ERIC Educational Resources Information Center

Xu, Hongjiang; Rondeau, Patrick J.; Mahenthiran, Sakthi

2011-01-01

Enterprise Resource Planning (ERP) system implementation projects are notoriously risky. While large-scale ERP cases continue to be developed, relatively few new ERP cases have been published that further ERP implementation education in small to medium size firms. This case details the implementation of a new ERP system in a medium sized…

Estimating the impact of enterprise resource planning project management decisions on post-implementation maintenance costs: a case study using simulation modelling

NASA Astrophysics Data System (ADS)

Fryling, Meg

2010-11-01

Organisations often make implementation decisions with little consideration for the maintenance phase of an enterprise resource planning (ERP) system, resulting in significant recurring maintenance costs. Poor cost estimations are likely related to the lack of an appropriate framework for enterprise-wide pre-packaged software maintenance, which requires an ongoing relationship with the software vendor (Markus, M.L., Tanis, C., and Fenema, P.C., 2000. Multisite ERP implementation. CACM, 43 (4), 42-46). The end result is that critical project decisions are made with little empirical data, resulting in substantial long-term cost impacts. The product of this research is a formal dynamic simulation model that enables theory testing, scenario exploration and policy analysis. The simulation model ERPMAINT1 was developed by combining and extending existing frameworks in several research domains, and by incorporating quantitative and qualitative case study data. The ERPMAINT1 model evaluates tradeoffs between different ERP project management decisions and their impact on post-implementation total cost of ownership (TCO). Through model simulations a variety of dynamic insights were revealed that could assist ERP project managers. Major findings from the simulation show that upfront investments in mentoring and system exposure translate to long-term cost savings. The findings also indicate that in addition to customisations, add-ons have a significant impact on TCO.

Emotion Processing by ERP Combined with Development and Plasticity.

PubMed

Ding, Rui; Li, Ping; Wang, Wei; Luo, Wenbo

2017-01-01

Emotions important for survival and social interaction have received wide and deep investigations. The application of the fMRI technique into emotion processing has obtained overwhelming achievements with respect to the localization of emotion processes. The ERP method, which possesses highly temporal resolution compared to fMRI, can be employed to investigate the time course of emotion processing. The emotional modulation of the ERP component has been verified across numerous researches. Emotions, described as dynamically developing along with the growing age, have the possibility to be enhanced through learning (or training) or to be damaged due to disturbances in growth, which is underlain by the neural plasticity of emotion-relevant nervous systems. And mood disorders with typical symptoms of emotion discordance probably have been caused by the dysfunctional neural plasticity.

Emotion Processing by ERP Combined with Development and Plasticity

PubMed Central

2017-01-01

Emotions important for survival and social interaction have received wide and deep investigations. The application of the fMRI technique into emotion processing has obtained overwhelming achievements with respect to the localization of emotion processes. The ERP method, which possesses highly temporal resolution compared to fMRI, can be employed to investigate the time course of emotion processing. The emotional modulation of the ERP component has been verified across numerous researches. Emotions, described as dynamically developing along with the growing age, have the possibility to be enhanced through learning (or training) or to be damaged due to disturbances in growth, which is underlain by the neural plasticity of emotion-relevant nervous systems. And mood disorders with typical symptoms of emotion discordance probably have been caused by the dysfunctional neural plasticity. PMID:28831313

Intrinsic Factors for Continued ERP Learning: A Precursor to Interdisciplinary ERP Curriculum Design

ERIC Educational Resources Information Center

Chen, Kuanchin; Razi, Muhammad; Rienzo, Thomas

2011-01-01

Unilateral enterprise resource planning (ERP) curriculum improvements from the instructor's perspective are likely to generate only limited success. Understanding student motivations and beliefs with ERP systems is the missing link to effective ERP education. Relatively little attention in the ERP literature has been given to student learning…

Anodonta imbecillis QA Test 1, Clinch River - Environmental Restoration Program (CR-ERP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1997-06-01

Toxicity testing of split whole sediment samples using juvenile freshwater mussels (Anodonta imbecillis) was conducted by TVA and CR-ERP personnel as part of the CR-ERP biomonitoring study of Clinch River sediments to provide a quality assurance mechanism for test organism quality and overall performance of the test. In addition, testing included procedures comparing daily renewal versus non-renewal of test sediments. Testing of sediment samples collected July 15 from Poplar Creek Miles 6.0 and 5.1 was conducted from July 21-30, 1993. Results from this test showed no toxicity (survival effects) to fresh-water mussels during a 9-day exposure to the sediments. Sidemore » by side testing of sediments with daily sediment renewal and no sediment renewal showed no differences between methods. This may be due to the absence of toxicity in both samples and may not reflect true differences between the two methods for toxic sediment.« less

P300-based brain-computer interface (BCI) event-related potentials (ERPs): People with amyotrophic lateral sclerosis (ALS) vs. age-matched controls.

PubMed

McCane, Lynn M; Heckman, Susan M; McFarland, Dennis J; Townsend, George; Mak, Joseph N; Sellers, Eric W; Zeitlin, Debra; Tenteromano, Laura M; Wolpaw, Jonathan R; Vaughan, Theresa M

2015-11-01

Brain-computer interfaces (BCIs) aimed at restoring communication to people with severe neuromuscular disabilities often use event-related potentials (ERPs) in scalp-recorded EEG activity. Up to the present, most research and development in this area has been done in the laboratory with young healthy control subjects. In order to facilitate the development of BCI most useful to people with disabilities, the present study set out to: (1) determine whether people with amyotrophic lateral sclerosis (ALS) and healthy, age-matched volunteers (HVs) differ in the speed and accuracy of their ERP-based BCI use; (2) compare the ERP characteristics of these two groups; and (3) identify ERP-related factors that might enable improvement in BCI performance for people with disabilities. Sixteen EEG channels were recorded while people with ALS or healthy age-matched volunteers (HVs) used a P300-based BCI. The subjects with ALS had little or no remaining useful motor control (mean ALS Functional Rating Scale-Revised 9.4 (±9.5SD) (range 0-25)). Each subject attended to a target item as the items in a 6×6 visual matrix flashed. The BCI used a stepwise linear discriminant function (SWLDA) to determine the item the user wished to select (i.e., the target item). Offline analyses assessed the latencies, amplitudes, and locations of ERPs to the target and non-target items for people with ALS and age-matched control subjects. BCI accuracy and communication rate did not differ significantly between ALS users and HVs. Although ERP morphology was similar for the two groups, their target ERPs differed significantly in the location and amplitude of the late positivity (P300), the amplitude of the early negativity (N200), and the latency of the late negativity (LN). The differences in target ERP components between people with ALS and age-matched HVs are consistent with the growing recognition that ALS may affect cortical function. The development of BCIs for use by this population may begin with studies in HVs but also needs to include studies in people with ALS. Their differences in ERP components may affect the selection of electrode montages, and might also affect the selection of presentation parameters (e.g., matrix design, stimulation rate). P300-based BCI performance in people severely disabled by ALS is similar to that of age-matched control subjects. At the same time, their ERP components differ to some degree from those of controls. Attention to these differences could contribute to the development of BCIs useful to those with ALS and possibly to others with severe neuromuscular disabilities. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Topographic ERP analyses: a step-by-step tutorial review.

PubMed

Murray, Micah M; Brunet, Denis; Michel, Christoph M

2008-06-01

In this tutorial review, we detail both the rationale for as well as the implementation of a set of analyses of surface-recorded event-related potentials (ERPs) that uses the reference-free spatial (i.e. topographic) information available from high-density electrode montages to render statistical information concerning modulations in response strength, latency, and topography both between and within experimental conditions. In these and other ways these topographic analysis methods allow the experimenter to glean additional information and neurophysiologic interpretability beyond what is available from canonical waveform analyses. In this tutorial we present the example of somatosensory evoked potentials (SEPs) in response to stimulation of each hand to illustrate these points. For each step of these analyses, we provide the reader with both a conceptual and mathematical description of how the analysis is carried out, what it yields, and how to interpret its statistical outcome. We show that these topographic analysis methods are intuitive and easy-to-use approaches that can remove much of the guesswork often confronting ERP researchers and also assist in identifying the information contained within high-density ERP datasets.

Episodic acidification of small streams in the northeastern united states: episodic response project

USGS Publications Warehouse

Wigington, P.J.; Baker, J.P.; DeWalle, David R.; Kretser, W.A.; Murdoch, Peter S.; Simonin, H.A.; Van Sickle, J.; Mcdowell, M.K.; Peck, D.V.; Barchet, W.R.

1996-01-01

The Episodic Response Project (ERP) was an interdisciplinary study designed to address uncertainties about the occurrence, nature, and biological effects of episodic acidification of streams in the northeastern United States. The ERP research consisted of intensive studies of the chemistry and biological effects of episodes in 13 streams draining forested watersheds in the three study regions: the Northern Appalachian region of Pennsylvania and the Catskill and Adirondack Mountains of New York. Wet deposition was measured in each of the three study regions. Using automated instruments and samplers, discharge and chemistry of each stream was monitored intensively from fall 1988 through spring 1990. Biological studies focused on brook trout and native forage fish. Experimental approaches included in situ bioassays, radio transmitter studies of fish movement, and fish population studies. This paper provides an overview of the ERP, describes the methodology used in hydrologic and water chemistry components of the study, and summarizes the characteristics of the study sites, including the climatic and deposition conditions during the ERP and the general chemical characteristics of the study streams.

Cardiovascular fitness and executive control during task-switching: an ERP study.

PubMed

Scisco, Jenna L; Leynes, P Andrew; Kang, Jie

2008-07-01

Cardiovascular fitness recently has been linked to executive control function in older adults. The present study examined the relationship between cardiovascular fitness and executive control in young adults using event-related potentials (ERPs). Participants completed a two-part experiment. In part one, a graded exercise test (GXT) was administered using a cycle ergometer to obtain VO(2)max, a measure of maximal oxygen uptake. High-fit participants had VO(2)max measures at or above the 70th percentile based on age and sex, and low-fit participants had VO(2)max measures at or below the 30th percentile. In part two, a task-switching paradigm was used to investigate executive control. Task-switching trials produced slower response times and greater amplitude for both the P3a and P3b components of the ERP relative to a non-switch trial block. No ERP components varied as a function of fitness group. These findings, combined with results from previous research, suggest that the relationship between greater cardiovascular fitness and better cognitive function emerges after early adulthood.

Purification and biochemical characterization of native ERp29 from rat liver

PubMed Central

2004-01-01

ERp29 is a recently characterized resident of the ER (endoplasmic reticulum) lumen that has broad biological significance, being expressed ubiquitously and abundantly in animal cells. As an apparent housekeeper, ERp29 is thought to be a general folding assistant for secretory proteins and to probably function as a PDI (protein disulphide isomerase)-like molecular chaperone. In the present paper, we report the first purification to homogeneity and direct functional analysis of native ERp29, which has led to the unexpected finding that ERp29 lacks PDI-like folding activities. ERp29 was purified 4800-fold in non-denaturing conditions exploiting an unusual affinity for heparin. Two additional biochemical hallmarks that will assist the classification of ERp29 homologues were identified, namely the idiosyncratic behaviours of ERp29 on size-exclusion chromatography (Mrmonomeric mass). In contrast with PDI and parallel-purified co-residents (calreticulin, ERp60), native ERp29 lacked classical chaperone, disulphide reductase and isomerase, and calcium-binding activities. In the chaperone assays, ERp29 neither protected substrate proteins against thermal aggregation nor interacted stably with chemically denatured proteins as detected by cross-linking. ERp29 also did not exhibit helper activity toward calreticulin (chaperone) or PDI and ERp60 (disulphide reductase). By refuting long-standing predictions about chaperone activity, these results expose ERp29 as a functionally distinct member of the ER machinery and prompt a revised hypothesis that ERp29 acts as a non-classical folding assistant. The native preparation and biochemical hallmarks established here provide a useful foundation for ongoing efforts to resolve the functional orphan status of ERp29. PMID:15500441

Quantifying fast optical signal and event-related potential relationships during a visual oddball task.

PubMed

Proulx, Nicole; Samadani, Ali-Akbar; Chau, Tom

2018-05-16

Event-related potentials (ERPs) have previously been used to confirm the existence of the fast optical signal (FOS) but validation methods have mainly been limited to exploring the temporal correspondence of FOS peaks to those of ERPs. The purpose of this study was to systematically quantify the relationship between FOS and ERP responses to a visual oddball task in both time and frequency domains. Near-infrared spectroscopy (NIRS) and electroencephalography (EEG) sensors were co-located over the prefrontal cortex while participants performed a visual oddball task. Fifteen participants completed 2 data collection sessions each, where they were instructed to keep a mental count of oddball images. The oddball condition produced a positive ERP at 200 ms followed by a negativity 300-500 ms after image onset in the frontal electrodes. In contrast to previous FOS studies, a FOS response was identified only in DC intensity signals and not in phase delay signals. A decrease in DC intensity was found 150-250 ms after oddball image onset with a 400-trial average in 10 of 15 participants. The latency of the positive 200 ms ERP and the FOS DC intensity decrease were significantly correlated for only 6 (out of 15) participants due to the low signal-to-noise ratio of the FOS response. Coherence values between the FOS and ERP oddball responses were found to be significant in the 3-5 Hz frequency band for 10 participants. A significant Granger causal influence of the ERP on the FOS oddball response was uncovered in the 2-6 Hz frequency band for 7 participants. Collectively, our findings suggest that, for a majority of participants, the ERP and the DC intensity signal of the FOS are spectrally coherent, specifically in narrow frequency bands previously associated with event-related oscillations in the prefrontal cortex. However, these electro-optical relationships were only found in a subset of participants. Further research on enhancing the quality of the event-related FOS signal is required before it can be practically exploited in applications such as brain-computer interfacing. Copyright © 2018. Published by Elsevier Inc.

Teaching ERP Systems: A Multi-Perspective View on the ERP System Market

ERIC Educational Resources Information Center

Winkelmann, Axel; Leyh, Christian

2010-01-01

In order to increase the diversity in IS education, we discuss an approach for teaching medium-sized ERP systems in university courses. Many of today's IS curricula are biased toward a few large ERP packages. Nevertheless, these ERP systems are only a part of the ERP market. Therefore, this paper describes a course outline for an additional course…

Exploring Education Culture by Employing Hofstede?s Cultural Dimensions to Evaluate the Effectiveness of the Current ERP Training Approach in Thailand

ERIC Educational Resources Information Center

Chayakonvikom, Monta; Fuangvut, Parin; Cannell, Stephen

2016-01-01

ERP training is a critical success factor in ERP implementation. The current ERP training was largely ineffective and caused user resistance and ERP implementation failure. The objective of this paper is to investigate whether the current ERP training approach can accommodate the cultural learning behaviors of end-users. Hofstede's cultural…

About the mechanism of ERP-system pilot test

NASA Astrophysics Data System (ADS)

Mitkov, V. V.; Zimin, V. V.

2018-05-01

In the paper the mathematical problem of defining the scope of pilot test is stated, which is a task of quadratic programming. The procedure of the problem solving includes the method of network programming based on the structurally similar network representation of the criterion and constraints and which reduces the original problem to a sequence of simpler evaluation tasks. The evaluation tasks are solved by the method of dichotomous programming.

Surgical Technical Evidence Review for Elective Total Joint Replacement Conducted for the AHRQ Safety Program for Improving Surgical Care and Recovery.

PubMed

Childers, Christopher P; Siletz, Anaar E; Singer, Emily S; Faltermeier, Claire; Hu, Q Lina; Ko, Clifford Y; Golladay, Gregory J; Kates, Stephen L; Wick, Elizabeth C; Maggard-Gibbons, Melinda

2018-01-01

Use of enhanced recovery pathways (ERPs) can improve patient outcomes, yet national implementation of these pathways remains low. The Agency for Healthcare Research and Quality (AHRQ; funder), the American College of Surgeons, and the Johns Hopkins Medicine Armstrong Institute for Patent Safety and Quality have developed the Safety Program for Improving Surgical Care and Recovery-a national effort to catalyze implementation of practices to improve perioperative care and enhance recovery of surgical patients. This review synthesizes evidence that can be used to develop a protocol for elective total knee arthroplasty (TKA) and total hip arthroplasty (THA). This review focuses on potential components of the protocol relevant to surgeons; anesthesia components are reported separately. Components were identified through review of existing pathways and from consultation with technical experts. For each, a structured review of MEDLINE identified systematic reviews, randomized trials, and observational studies that reported on these components in patients undergoing elective TKA/THA. This primary evidence review was combined with existing clinical guidelines in a narrative format. Sixteen components were reviewed. Of the 10 preoperative components, most were focused on risk factor assessment including anemia, diabetes mellitus, tobacco use, obesity, nutrition, immune-modulating therapy, and opiates. Preoperative education, venous thromboembolism (VTE) prophylaxis, and bathing/ Staphylococcus aureus decolonization were also included. The routine use of drains was the only intraoperative component evaluated. The 5 postoperative components included early mobilization, continuous passive motion, extended duration VTE prophylaxis, early oral alimentation, and discharge planning. This review synthesizes the evidence supporting potential surgical components of an ERP for elective TKA/THA. The AHRQ Safety Program for Improving Surgical Care and Recovery aims to guide hospitals and surgeons in identifying the best practices to implement in the surgical care of TKA and THA patients.

Auditory P300 event related potentials in acute and transient psychosis-Comparison with schizophrenia.

PubMed

Sahoo, Swapnajeet; Malhotra, Savita; Basu, Debasish; Modi, Manish

2016-10-01

Limited biological research data are available on acute and transient psychotic disorder (ATPD) vis-à-vis schizophrenia. P300 event related potentials (ERP) have been extensively studied as an important neurophysiological parameter in schizophrenia. However, no P300 ERP studies comparing the two disorders are available. We compared auditory P300 ERP in patients remitted from ATPD with schizophrenia in remission and biologically unrelated healthy controls. In this case-control study design, 25 subjects remitted from ATPD were age-/gender-matched with healthy controls and patients with schizophrenia in remission. Clinical assessment and auditory P300 ERP (amplitude and latencies at central and parietal sites, reaction time) were recorded. The ERP parameters were compared across the three groups. All three groups showed significant differences in P300 amplitudes and latencies at central and parietal sites. Schizophrenia group differed significantly (p<0.001) from the ATPD group in all the P300 parameters. The ATPD group was found to have lower Pz latency (p<0.05) and lower mean reaction time (p<0.001) as compared to healthy controls. The results suggest that P300 could easily distinguish between ATPD and schizophrenia in remission, thus neurophysiologically differentiating the two disorders. Lower P300 latency and reaction time, which indicate hyper-arousability, distinguished ATPD from normal controls, with implications for a better understanding of ATPD. Copyright © 2016 Elsevier B.V. All rights reserved.

A Multi-Dimensional Functional Principal Components Analysis of EEG Data

PubMed Central

Hasenstab, Kyle; Scheffler, Aaron; Telesca, Donatello; Sugar, Catherine A.; Jeste, Shafali; DiStefano, Charlotte; Şentürk, Damla

2017-01-01

Summary The electroencephalography (EEG) data created in event-related potential (ERP) experiments have a complex high-dimensional structure. Each stimulus presentation, or trial, generates an ERP waveform which is an instance of functional data. The experiments are made up of sequences of multiple trials, resulting in longitudinal functional data and moreover, responses are recorded at multiple electrodes on the scalp, adding an electrode dimension. Traditional EEG analyses involve multiple simplifications of this structure to increase the signal-to-noise ratio, effectively collapsing the functional and longitudinal components by identifying key features of the ERPs and averaging them across trials. Motivated by an implicit learning paradigm used in autism research in which the functional, longitudinal and electrode components all have critical interpretations, we propose a multidimensional functional principal components analysis (MD-FPCA) technique which does not collapse any of the dimensions of the ERP data. The proposed decomposition is based on separation of the total variation into subject and subunit level variation which are further decomposed in a two-stage functional principal components analysis. The proposed methodology is shown to be useful for modeling longitudinal trends in the ERP functions, leading to novel insights into the learning patterns of children with Autism Spectrum Disorder (ASD) and their typically developing peers as well as comparisons between the two groups. Finite sample properties of MD-FPCA are further studied via extensive simulations. PMID:28072468

A multi-dimensional functional principal components analysis of EEG data.

PubMed

Hasenstab, Kyle; Scheffler, Aaron; Telesca, Donatello; Sugar, Catherine A; Jeste, Shafali; DiStefano, Charlotte; Şentürk, Damla

2017-09-01

The electroencephalography (EEG) data created in event-related potential (ERP) experiments have a complex high-dimensional structure. Each stimulus presentation, or trial, generates an ERP waveform which is an instance of functional data. The experiments are made up of sequences of multiple trials, resulting in longitudinal functional data and moreover, responses are recorded at multiple electrodes on the scalp, adding an electrode dimension. Traditional EEG analyses involve multiple simplifications of this structure to increase the signal-to-noise ratio, effectively collapsing the functional and longitudinal components by identifying key features of the ERPs and averaging them across trials. Motivated by an implicit learning paradigm used in autism research in which the functional, longitudinal, and electrode components all have critical interpretations, we propose a multidimensional functional principal components analysis (MD-FPCA) technique which does not collapse any of the dimensions of the ERP data. The proposed decomposition is based on separation of the total variation into subject and subunit level variation which are further decomposed in a two-stage functional principal components analysis. The proposed methodology is shown to be useful for modeling longitudinal trends in the ERP functions, leading to novel insights into the learning patterns of children with Autism Spectrum Disorder (ASD) and their typically developing peers as well as comparisons between the two groups. Finite sample properties of MD-FPCA are further studied via extensive simulations. © 2017, The International Biometric Society.

Multivariate Genetic Correlates of the Auditory Paired Stimuli-Based P2 Event-Related Potential in the Psychosis Dimension From the BSNIP Study.

PubMed

Mokhtari, Mohammadreza; Narayanan, Balaji; Hamm, Jordan P; Soh, Pauline; Calhoun, Vince D; Ruaño, Gualberto; Kocherla, Mohan; Windemuth, Andreas; Clementz, Brett A; Tamminga, Carol A; Sweeney, John A; Keshavan, Matcheri S; Pearlson, Godfrey D

2016-05-01

The complex molecular etiology of psychosis in schizophrenia (SZ) and psychotic bipolar disorder (PBP) is not well defined, presumably due to their multifactorial genetic architecture. Neurobiological correlates of psychosis can be identified through genetic associations of intermediate phenotypes such as event-related potential (ERP) from auditory paired stimulus processing (APSP). Various ERP components of APSP are heritable and aberrant in SZ, PBP and their relatives, but their multivariate genetic factors are less explored. We investigated the multivariate polygenic association of ERP from 64-sensor auditory paired stimulus data in 149 SZ, 209 PBP probands, and 99 healthy individuals from the multisite Bipolar-Schizophrenia Network on Intermediate Phenotypes study. Multivariate association of 64-channel APSP waveforms with a subset of 16 999 single nucleotide polymorphisms (SNPs) (reduced from 1 million SNP array) was examined using parallel independent component analysis (Para-ICA). Biological pathways associated with the genes were assessed using enrichment-based analysis tools. Para-ICA identified 2 ERP components, of which one was significantly correlated with a genetic network comprising multiple linearly coupled gene variants that explained ~4% of the ERP phenotype variance. Enrichment analysis revealed epidermal growth factor, endocannabinoid signaling, glutamatergic synapse and maltohexaose transport associated with P2 component of the N1-P2 ERP waveform. This ERP component also showed deficits in SZ and PBP. Aberrant P2 component in psychosis was associated with gene networks regulating several fundamental biologic functions, either general or specific to nervous system development. The pathways and processes underlying the gene clusters play a crucial role in brain function, plausibly implicated in psychosis. © The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Examining Event-Related Potential (ERP) Correlates of Decision Bias in Recognition Memory Judgments

PubMed Central

Hill, Holger; Windmann, Sabine

2014-01-01

Memory judgments can be based on accurate memory information or on decision bias (the tendency to report that an event is part of episodic memory when one is in fact unsure). Event related potentials (ERP) correlates are important research tools for elucidating the dynamics underlying memory judgments but so far have been established only for investigations of accurate old/new discrimination. To identify the ERP correlates of bias, and observe how these interact with ERP correlates of memory, we conducted three experiments that manipulated decision bias within participants via instructions during recognition memory tests while their ERPs were recorded. In Experiment 1, the bias manipulation was performed between blocks of trials (automatized bias) and compared to trial-by-trial shifts of bias in accord with an external cue (flexibly controlled bias). In Experiment 2, the bias manipulation was performed at two different levels of accurate old/new discrimination as the memory strength of old (studied) items was varied. In Experiment 3, the bias manipulation was added to another, bottom-up driven manipulation of bias induced via familiarity. In the first two Experiments, and in the low familiarity condition of Experiment 3, we found evidence of an early frontocentral ERP component at 320 ms poststimulus (the FN320) that was sensitive to the manipulation of bias via instruction, with more negative amplitudes indexing more liberal bias. By contrast, later during the trial (500–700 ms poststimulus), bias effects interacted with old/new effects across all three experiments. Results suggest that the decision criterion is typically activated early during recognition memory trials, and is integrated with retrieved memory signals and task-specific processing demands later during the trial. More generally, the findings demonstrate how ERPs can help to specify the dynamics of recognition memory processes under top-down and bottom-up controlled retrieval conditions. PMID:25264982

Examining Event-Related Potential (ERP) correlates of decision bias in recognition memory judgments.

PubMed

Hill, Holger; Windmann, Sabine

2014-01-01

Memory judgments can be based on accurate memory information or on decision bias (the tendency to report that an event is part of episodic memory when one is in fact unsure). Event related potentials (ERP) correlates are important research tools for elucidating the dynamics underlying memory judgments but so far have been established only for investigations of accurate old/new discrimination. To identify the ERP correlates of bias, and observe how these interact with ERP correlates of memory, we conducted three experiments that manipulated decision bias within participants via instructions during recognition memory tests while their ERPs were recorded. In Experiment 1, the bias manipulation was performed between blocks of trials (automatized bias) and compared to trial-by-trial shifts of bias in accord with an external cue (flexibly controlled bias). In Experiment 2, the bias manipulation was performed at two different levels of accurate old/new discrimination as the memory strength of old (studied) items was varied. In Experiment 3, the bias manipulation was added to another, bottom-up driven manipulation of bias induced via familiarity. In the first two Experiments, and in the low familiarity condition of Experiment 3, we found evidence of an early frontocentral ERP component at 320 ms poststimulus (the FN320) that was sensitive to the manipulation of bias via instruction, with more negative amplitudes indexing more liberal bias. By contrast, later during the trial (500-700 ms poststimulus), bias effects interacted with old/new effects across all three experiments. Results suggest that the decision criterion is typically activated early during recognition memory trials, and is integrated with retrieved memory signals and task-specific processing demands later during the trial. More generally, the findings demonstrate how ERPs can help to specify the dynamics of recognition memory processes under top-down and bottom-up controlled retrieval conditions.

Motivated To Win: Relationship between Anticipatory and Outcome Reward-Related Neural Activity

PubMed Central

Nusslock, Robin

2015-01-01

Reward-processing involves two temporal stages characterized by two distinct neural processes: reward-anticipation and reward-outcome. Intriguingly, very little research has examined the relationship between neural processes involved in reward-anticipation and reward-outcome. To investigate this, one needs to consider the heterogeneity of reward-processing within each stage. To identify different stages of reward processing, we adapted a reward time-estimation task. While EEG data were recorded, participants were instructed to button-press 3.5 s after the onset of an Anticipation-Cue and received monetary reward for good time-estimation on the Reward trials, but not on No-Reward trials. We first separated reward-anticipation into event related potentials (ERPs) occurring at three sub-stages: reward/no-reward cue-evaluation, motor-preparation and feedback-anticipation. During reward/no-reward cue-evaluation, the Reward-Anticipation Cue led to a smaller N2 and larger P3. During motor-preparation, we report, for the first time, that the Reward-Anticipation Cue enhanced the Readiness Potential (RP), starting approximately 1 s before movement. At the subsequent feedback-anticipation stage, the Reward-Anticipation Cue elevated the Stimulus-Preceding Negativity (SPN). We also separated reward-outcome ERPs into different components occurring at different time-windows: the Feedback-Related Negativity (FRN), Feedback-P3 (FB-P3) and Late-Positive Potentials (LPP). Lastly, we examined the relationship between reward-anticipation and reward-outcome ERPs. We report that individual-differences in specific reward-anticipation ERPs uniquely predicted specific reward-outcome ERPs. In particular, the reward-anticipation Early-RP (1 to .8 s before movement) predicted early reward-outcome ERPs (FRN and FB-P3), whereas, the reward-anticipation SPN most strongly predicted a later reward-outcome ERP (LPP). Results have important implications for understanding the nature of the relationship between reward-anticipation and reward-outcome neural-processes. PMID:26433773

Critical challenges in ERP implementation: A qualitative case study in the Canadian oil and gas industry

NASA Astrophysics Data System (ADS)

Menon, Sreekumar A.

This exploratory qualitative single-case study examines critical challenges encountered during ERP implementation based on individual perspectives in four project roles: senior leaders, project managers, project team members, and business users, all specifically in Canadian oil and gas industry. Data was collected by interviewing participants belonging to these categories, and by analyzing project documentation about ERP implementation. The organization for the case study was a leading multinational oil and gas company having a substantial presence in the energy sector in Canada. The study results were aligned with the six management questions regarding critical challenges in ERP: (a) circumstances to implement ERP, (b) benefits and process improvements achieved, (c) best practices implemented, (d) critical challenges encountered, (e) strategies and mitigating actions used, and (f) recommendations to improve future ERP implementations. The study results highlight six key findings. First, the study provided valid circumstances for implementing ERP systems. Second, the study underscored the importance of benefits and process improvements in ERP implementation. Third, the study highlighted that adoption of best practices is crucial for ERP Implementation. Fourth, the study found that critical challenges are encountered in ERP Implementation and are significant during ERP implementation. Fifth, the study found that strategies and mitigating actions can overcome challenges in ERP implementation. Finally, the study provided ten major recommendations on how to improve future ERP implementations.

Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis.

PubMed

Liu, Miao; Du, Lingyao; He, Zhiliang; Yan, Libo; Shi, Ying; Shang, Jin; Tang, Hong

2017-01-01

Aim. ERp57 is involved in virus induced endoplasmic reticulum stress (ERS) and plays an important role in tumorigenesis. This study aimed to find whether HBV infection altered ERp57 expression and whether ERp57 regulation was involved in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) genesis. Materials and Methods. HBV-HCC tissues, chronic hepatitis B (CHB) liver tissues, and normal liver tissues were acquired. ERp57 expressions in these tissues were detected through immunohistochemistry (IHC). And ERp57 expression in liver cell line L02, HBV replicative liver cell line L02-pHBV4.1, and HCC cell lines were detected through western blot for verification. Then medical data on patients providing HCC tissues were collected and analyzed along with ERp57 expression. Results. Higher ERp57 expression was found in HCC and CHB tissues ( p < 0.001). And HCC cell lines and L02-pHBV4.1 presented higher ERp57 expression as well. In patients, ERp57 expression showed significant differences between death and survival groups ( p = 0.037). And cumulative survival in patients with higher ERp57 (score ⩾ 8.75) is significantly lower ( p = 0.009). Conclusion. Our study found increased expression of ERp57 in HBV-HCC. Such altered expression could be related to HBV infection and high ERp57 expression may lead to poor prognosis of HBV-HCC patients.

The t-CWT: a new ERP detection and quantification method based on the continuous wavelet transform and Student's t-statistics.

PubMed

Bostanov, Vladimir; Kotchoubey, Boris

2006-12-01

This study was aimed at developing a method for extraction and assessment of event-related brain potentials (ERP) from single-trials. This method should be applicable in the assessment of single persons' ERPs and should be able to handle both single ERP components and whole waveforms. We adopted a recently developed ERP feature extraction method, the t-CWT, for the purposes of hypothesis testing in the statistical assessment of ERPs. The t-CWT is based on the continuous wavelet transform (CWT) and Student's t-statistics. The method was tested in two ERP paradigms, oddball and semantic priming, by assessing individual-participant data on a single-trial basis, and testing the significance of selected ERP components, P300 and N400, as well as of whole ERP waveforms. The t-CWT was also compared to other univariate and multivariate ERP assessment methods: peak picking, area computation, discrete wavelet transform (DWT) and principal component analysis (PCA). The t-CWT produced better results than all of the other assessment methods it was compared with. The t-CWT can be used as a reliable and powerful method for ERP-component detection and testing of statistical hypotheses concerning both single ERP components and whole waveforms extracted from either single persons' or group data. The t-CWT is the first such method based explicitly on the criteria of maximal statistical difference between two average ERPs in the time-frequency domain and is particularly suitable for ERP assessment of individual data (e.g. in clinical settings), but also for the investigation of small and/or novel ERP effects from group data.

Effects of perceptual and semantic cues on ERP modulations associated with prospective memory.

PubMed

Cousens, Ross; Cutmore, Timothy; Wang, Ya; Wilson, Jennifer; Chan, Raymond C K; Shum, David H K

2015-10-01

Prospective memory involves the formation and execution of intended actions and is essential for autonomous living. In this study (N=32), the effect of the nature of PM cues (semantic versus perceptual) on established event-related potentials (ERPs) elicited in PM tasks (N300 and prospective positivity) was investigated. PM cues defined by their perceptual features clearly elicited the N300 and prospective positivity whereas PM cues defined by semantic relatedness elicited prospective positivity. This calls into question the view that the N300 is a marker of general processes underlying detection of PM cues, but supports existing research showing that prospective positivity represents general post-retrieval processes that follow detection of PM cues. Continued refinement of ERP paradigms for understanding the neural correlates of PM is needed. Copyright © 2015 Elsevier B.V. All rights reserved.

Differentiating location- and distance-based processes in memory for time: an ERP study.

PubMed

Curran, Tim; Friedman, William J

2003-09-01

Memory for the time of events may benefit from reconstructive, location-based, and distance-based processes, but these processes are difficult to dissociate with behavioral methods. Neuropsychological research has emphasized the contribution of prefrontal brain mechanisms to memory for time but has not clearly differentiated location- from distance-based processing. The present experiment recorded event-related brain potentials (ERPs) while subjects completed two different temporal memory tests, designed to emphasize either location- or distance-based processing. The subjects' reports of location-based versus distance-based strategies and the reaction time pattern validated our experimental manipulation. Late (800-1,800 msec) frontal ERP effects were related to location-based processing. The results provide support for a two-process theory of memory for time and suggest that frontal memory mechanisms are specifically related to reconstructive, location-based processing.

An ERP study on initial second language vocabulary learning.

PubMed

Yum, Yen Na; Midgley, Katherine J; Holcomb, Phillip J; Grainger, Jonathan

2014-04-01

This study examined the very initial phases of orthographic and semantic acquisition in monolingual native English speakers learning Chinese words under controlled laboratory conditions. Participants engaged in 10 sessions of vocabulary learning, four of which were used to obtain ERPs. Performance in behavioral tests improved over sessions, and these data were used to define fast and slow learners. Most important is that ERPs in the two groups of learners revealed qualitatively distinct learning patterns. Only fast learners showed a left-lateralized increase in N170 amplitude with training. Furthermore, only fast learners showed an increased N400 amplitude with training, with a distinct anterior distribution. Slow learners, on the other hand, showed a posterior positive effect, with increasingly positive-going waveforms in occipital sites as training progressed. Possible mechanisms underlying these qualitative differences are discussed. Copyright © 2014 Society for Psychophysiological Research.

Self-reflection modulates the outcome evaluation process: Evidence from an ERP study.

PubMed

Zhu, Xiangru; Gu, Ruolei; Wu, Haiyan; Luo, Yuejia

2015-12-01

Recent research demonstrated structural overlap between reward and self processing, but the functional relationship that explains how self processing influences reward processing remains unclear. The present study used an experimentally constrained reflection task to investigate whether individuals' outcome evaluations in a gambling task are modulated by task-unrelated self- and other-reflection processes. The self- and other-reflection task contained descriptions of the self or others, and brain event-related potentials (ERPs) were recorded while 16 normal adults performed a gambling task. The ERP analysis focused on the feedback-related negativity (FRN) component. We found that the difference wave of FRN increased in the self-reflection condition compared with the other-reflection condition. The present findings provide direct evidence that self processing can influence reward processing. Copyright © 2015 Elsevier B.V. All rights reserved.

Behavioral and brain pattern differences between acting and observing in an auditory task

PubMed Central

Karanasiou, Irene S; Papageorgiou, Charalabos; Tsianaka, Eleni I; Matsopoulos, George K; Ventouras, Errikos M; Uzunoglu, Nikolaos K

2009-01-01

Background Recent research has shown that errors seem to influence the patterns of brain activity. Additionally current notions support the idea that similar brain mechanisms are activated during acting and observing. The aim of the present study was to examine the patterns of brain activity of actors and observers elicited upon receiving feedback information of the actor's response. Methods The task used in the present research was an auditory identification task that included both acting and observing settings, ensuring concurrent ERP measurements of both participants. The performance of the participants was investigated in conditions of varying complexity. ERP data were analyzed with regards to the conditions of acting and observing in conjunction to correct and erroneous responses. Results The obtained results showed that the complexity induced by cue dissimilarity between trials was a demodulating factor leading to poorer performance. The electrophysiological results suggest that feedback information results in different intensities of the ERP patterns of observers and actors depending on whether the actor had made an error or not. The LORETA source localization method yielded significantly larger electrical activity in the supplementary motor area (Brodmann area 6), the posterior cingulate gyrus (Brodmann area 31/23) and the parietal lobe (Precuneus/Brodmann area 7/5). Conclusion These findings suggest that feedback information has a different effect on the intensities of the ERP patterns of actors and observers depending on whether the actor committed an error. Certain neural systems, including medial frontal area, posterior cingulate gyrus and precuneus may mediate these modulating effects. Further research is needed to elucidate in more detail the neuroanatomical and neuropsychological substrates of these systems. PMID:19154586

Neural Correlates of Selective Attention With Hearing Aid Use Followed by ReadMyQuips Auditory Training Program.

PubMed

Rao, Aparna; Rishiq, Dania; Yu, Luodi; Zhang, Yang; Abrams, Harvey

The objectives of this study were to investigate the effects of hearing aid use and the effectiveness of ReadMyQuips (RMQ), an auditory training program, on speech perception performance and auditory selective attention using electrophysiological measures. RMQ is an audiovisual training program designed to improve speech perception in everyday noisy listening environments. Participants were adults with mild to moderate hearing loss who were first-time hearing aid users. After 4 weeks of hearing aid use, the experimental group completed RMQ training in 4 weeks, and the control group received listening practice on audiobooks during the same period. Cortical late event-related potentials (ERPs) and the Hearing in Noise Test (HINT) were administered at prefitting, pretraining, and post-training to assess effects of hearing aid use and RMQ training. An oddball paradigm allowed tracking of changes in P3a and P3b ERPs to distractors and targets, respectively. Behavioral measures were also obtained while ERPs were recorded from participants. After 4 weeks of hearing aid use but before auditory training, HINT results did not show a statistically significant change, but there was a significant P3a reduction. This reduction in P3a was correlated with improvement in d prime (d') in the selective attention task. Increased P3b amplitudes were also correlated with improvement in d' in the selective attention task. After training, this correlation between P3b and d' remained in the experimental group, but not in the control group. Similarly, HINT testing showed improved speech perception post training only in the experimental group. The criterion calculated in the auditory selective attention task showed a reduction only in the experimental group after training. ERP measures in the auditory selective attention task did not show any changes related to training. Hearing aid use was associated with a decrement in involuntary attention switch to distractors in the auditory selective attention task. RMQ training led to gains in speech perception in noise and improved listener confidence in the auditory selective attention task.

A simple ERP method for quantitative analysis of cognitive workload in myoelectric prosthesis control and human-machine interaction.

PubMed

Deeny, Sean; Chicoine, Caitlin; Hargrove, Levi; Parrish, Todd; Jayaraman, Arun

2014-01-01

Common goals in the development of human-machine interface (HMI) technology are to reduce cognitive workload and increase function. However, objective and quantitative outcome measures assessing cognitive workload have not been standardized for HMI research. The present study examines the efficacy of a simple event-related potential (ERP) measure of cortical effort during myoelectric control of a virtual limb for use as an outcome tool. Participants trained and tested on two methods of control, direct control (DC) and pattern recognition control (PRC), while electroencephalographic (EEG) activity was recorded. Eighteen healthy participants with intact limbs were tested using DC and PRC under three conditions: passive viewing, easy, and hard. Novel auditory probes were presented at random intervals during testing, and significant task-difficulty effects were observed in the P200, P300, and a late positive potential (LPP), supporting the efficacy of ERPs as a cognitive workload measure in HMI tasks. LPP amplitude distinguished DC from PRC in the hard condition with higher amplitude in PRC, consistent with lower cognitive workload in PRC relative to DC for complex movements. Participants completed trials faster in the easy condition using DC relative to PRC, but completed trials more slowly using DC relative to PRC in the hard condition. The results provide promising support for ERPs as an outcome measure for cognitive workload in HMI research such as prosthetics, exoskeletons, and other assistive devices, and can be used to evaluate and guide new technologies for more intuitive HMI control.

Competitive Semantic Memory Retrieval: Temporal Dynamics Revealed by Event-Related Potentials

PubMed Central

Hellerstedt, Robin; Johansson, Mikael

2016-01-01

Memories compete for retrieval when they are related to a common retrieval cue. Previous research has shown that retrieval of a target memory may lead to subsequent retrieval-induced forgetting (RIF) of currently irrelevant competing memories. In the present study, we investigated the time course of competitive semantic retrieval and examined the neurocognitive mechanisms underlying RIF. We contrasted two theoretical accounts of RIF by examining a critical aspect of this memory phenomenon, namely the extent to which it depends on successful retrieval of the target memory. Participants first studied category-exemplar word-pairs (e.g. Fruit—Apple). Next, we recorded electrophysiological measures of brain activity while the participants performed a competitive semantic cued-recall task. In this task, the participants were provided with the studied categories but they were instructed to retrieve other unstudied exemplars (e.g. Fruit—Ma__?). We investigated the event-related potential (ERP) correlates of retrieval success by comparing ERPs from successful and failed retrieval trials. To isolate the ERP correlates of continuous retrieval attempts from the ERP correlates of retrieval success, we included an impossible retrieval condition, with incompletable word-stem cues (Drinks—Wy__) and compared it with a non-retrieval presentation baseline condition (Occupation—Dentist). The participants’ memory for all the studied exemplars was tested in the final phase of the experiment. Taken together, the behavioural results suggest that RIF is independent of target retrieval. Beyond investigating the mechanisms underlying RIF, the present study also elucidates the temporal dynamics of semantic cued-recall by isolating the ERP correlates of retrieval attempt and retrieval success. The ERP results revealed that retrieval attempt is reflected in a late posterior negativity, possibly indicating construction of candidates for completing the word-stem cue and retrieval monitoring whereas retrieval success was reflected in an anterior positive slow wave. PMID:26901865

Syntax, concepts, and logic in the temporal dynamics of language comprehension: evidence from event-related potentials.

PubMed

Steinhauer, Karsten; Drury, John E; Portner, Paul; Walenski, Matthew; Ullman, Michael T

2010-05-01

Logic has been intertwined with the study of language and meaning since antiquity, and such connections persist in present day research in linguistic theory (formal semantics) and cognitive psychology (e.g., studies of human reasoning). However, few studies in cognitive neuroscience have addressed logical dimensions of sentence-level language processing, and none have directly compared these aspects of processing with syntax and lexical/conceptual-semantics. We used ERPs to examine a violation paradigm involving "Negative Polarity Items" or NPIs (e.g., ever/any), which are sensitive to logical/truth-conditional properties of the environments in which they occur (e.g., presence/absence of negation in: John hasn't ever been to Paris, versus: John has *ever been to Paris). Previous studies examining similar types of contrasts found a mix of effects on familiar ERP components (e.g., LAN, N400, P600). We argue that their experimental designs and/or analyses were incapable of separating which effects are connected to NPI-licensing violations proper. Our design enabled statistical analyses teasing apart genuine violation effects from independent effects tied solely to lexical/contextual factors. Here unlicensed NPIs elicited a late P600 followed in onset by a late left anterior negativity (or "L-LAN"), an ERP profile which has also appeared elsewhere in studies targeting logical semantics. Crucially, qualitatively distinct ERP-profiles emerged for syntactic and conceptual semantic violations which we also tested here. We discuss how these findings may be linked to previous findings in the ERP literature. Apart from methodological recommendations, we suggest that the study of logical semantics may aid advancing our understanding of the underlying neurocognitive etiology of ERP components. 2010 Elsevier Ltd. All rights reserved.

The relationship between somatic and cognitive-affective depression symptoms and error-related ERPs.

PubMed

Bridwell, David A; Steele, Vaughn R; Maurer, J Michael; Kiehl, Kent A; Calhoun, Vince D

2015-02-01

The symptoms that contribute to the clinical diagnosis of depression likely emerge from, or are related to, underlying cognitive deficits. To understand this relationship further, we examined the relationship between self-reported somatic and cognitive-affective Beck'sDepression Inventory-II (BDI-II) symptoms and aspects of cognitive control reflected in error event-related potential (ERP) responses. Task and assessment data were analyzed within 51 individuals. The group contained a broad distribution of depressive symptoms, as assessed by BDI-II scores. ERPs were collected following error responses within a go/no-go task. Individual error ERP amplitudes were estimated by conducting group independent component analysis (ICA) on the electroencephalographic (EEG) time series and analyzing the individual reconstructed source epochs. Source error amplitudes were correlated with the subset of BDI-II scores representing somatic and cognitive-affective symptoms. We demonstrate a negative relationship between somatic depression symptoms (i.e. fatigue or loss of energy) (after regressing out cognitive-affective scores, age and IQ) and the central-parietal ERP response that peaks at 359 ms. The peak amplitudes within this ERP response were not significantly related to cognitive-affective symptom severity (after regressing out the somatic symptom scores, age, and IQ). These findings were obtained within a population of female adults from a maximum-security correctional facility. Thus, additional research is required to verify that they generalize to the broad population. These results suggest that individuals with greater somatic depression symptoms demonstrate a reduced awareness of behavioral errors, and help clarify the relationship between clinical measures of self-reported depression symptoms and cognitive control. Copyright © 2014 Elsevier B.V. All rights reserved.

Analysis of independent components of cognitive event related potentials in a group of ADHD adults.

PubMed

Markovska-Simoska, Silvana; Pop-Jordanova, Nada; Pop-Jordanov, Jordan

In the last decade, many studies have tried to define the neural correlates of attention deficit hyperactivity disorder (ADHD). The main aim of this study is the comparison of the ERPs independent components in the four QEEG subtypes in a group of ADHD adults as a basis for defining the corresponding endophenotypes among ADHD population. Sixty-seven adults diagnosed as ADHD according to the DSM-IV criteria and 50 age-matched control subjects participated in the study. The brain activity of the subjects was recorded by 19 channel quantitative electroencephalography (QEEG) system in two neuropsychological tasks (visual and emotional continuous performance tests). The ICA method was applied for separation of the independent ERPs components. The components were associated with distinct psychological operations, such as engagement operations (P3bP component), comparison (vcomTL and vcom TR), motor inhibition (P3supF) and monitoring (P4monCC) operations. The ERPs results point out that there is disturbance in executive functioning in investigated ADHD group obtained by the significantly lower amplitude and longer latency for the engagement (P3bP), motor inhibition (P3supF) and monitoring (P4monCC) components. Particularly, the QEEG subtype IV was with the most significant ERPs differences comparing to the other subtypes. In particular, the most prominent difference in the ERPs independent components for the QEEG subtype IV in comparison to other three subtypes, rise many questions and becomes the subject for future research. This study aims to advance and facilitate the use of neurophysiological procedures (QEEG and ERPs) in clinical practice as objective measures of ADHD for better assessment, subtyping and treatment of ADHD.

An automated approach towards detecting complex behaviours in deep brain oscillations.

PubMed

Mace, Michael; Yousif, Nada; Naushahi, Mohammad; Abdullah-Al-Mamun, Khondaker; Wang, Shouyan; Nandi, Dipankar; Vaidyanathan, Ravi

2014-03-15

Extracting event-related potentials (ERPs) from neurological rhythms is of fundamental importance in neuroscience research. Standard ERP techniques typically require the associated ERP waveform to have low variance, be shape and latency invariant and require many repeated trials. Additionally, the non-ERP part of the signal needs to be sampled from an uncorrelated Gaussian process. This limits methods of analysis to quantifying simple behaviours and movements only when multi-trial data-sets are available. We introduce a method for automatically detecting events associated with complex or large-scale behaviours, where the ERP need not conform to the aforementioned requirements. The algorithm is based on the calculation of a detection contour and adaptive threshold. These are combined using logical operations to produce a binary signal indicating the presence (or absence) of an event with the associated detection parameters tuned using a multi-objective genetic algorithm. To validate the proposed methodology, deep brain signals were recorded from implanted electrodes in patients with Parkinson's disease as they participated in a large movement-based behavioural paradigm. The experiment involved bilateral recordings of local field potentials from the sub-thalamic nucleus (STN) and pedunculopontine nucleus (PPN) during an orientation task. After tuning, the algorithm is able to extract events achieving training set sensitivities and specificities of [87.5 ± 6.5, 76.7 ± 12.8, 90.0 ± 4.1] and [92.6 ± 6.3, 86.0 ± 9.0, 29.8 ± 12.3] (mean ± 1 std) for the three subjects, averaged across the four neural sites. Furthermore, the methodology has the potential for utility in real-time applications as only a single-trial ERP is required. Copyright © 2013 Elsevier B.V. All rights reserved.

Neural Mechanisms Underlying the Cost of Task Switching: An ERP Study

PubMed Central

Li, Ling; Wang, Meng; Zhao, Qian-Jing; Fogelson, Noa

2012-01-01

Background When switching from one task to a new one, reaction times are prolonged. This phenomenon is called switch cost (SC). Researchers have recently used several kinds of task-switching paradigms to uncover neural mechanisms underlying the SC. Task-set reconfiguration and passive dissipation of a previously relevant task-set have been reported to contribute to the cost of task switching. Methodology/Principal Findings An unpredictable cued task-switching paradigm was used, during which subjects were instructed to switch between a color and an orientation discrimination task. Electroencephalography (EEG) and behavioral measures were recorded in 14 subjects. Response-stimulus interval (RSI) and cue-stimulus interval (CSI) were manipulated with short and long intervals, respectively. Switch trials delayed reaction times (RTs) and increased error rates compared with repeat trials. The SC of RTs was smaller in the long CSI condition. For cue-locked waveforms, switch trials generated a larger parietal positive event-related potential (ERP), and a larger slow parietal positivity compared with repeat trials in the short and long CSI condition. Neural SC of cue-related ERP positivity was smaller in the long RSI condition. For stimulus-locked waveforms, a larger switch-related central negative ERP component was observed, and the neural SC of the ERP negativity was smaller in the long CSI. Results of standardized low resolution electromagnetic tomography (sLORETA) for both ERP positivity and negativity showed that switch trials evoked larger activation than repeat trials in dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC). Conclusions/Significance The results provide evidence that both RSI and CSI modulate the neural activities in the process of task-switching, but that these have a differential role during task-set reconfiguration and passive dissipation of a previously relevant task-set. PMID:22860090

SYNTAX, CONCEPTS, AND LOGIC IN THE TEMPORAL DYNAMICS OF LANGUAGE COMPREHENSION: EVIDENCE FROM EVENT RELATED POTENTIALS

PubMed Central

Steinhauer, Karsten; Drury, John E.; Portner, Paul; Walenski, Matthew; Ullman, Michael T.

2010-01-01

Logic has been intertwined with the study of language and meaning since antiquity, and such connections persist in present day research in linguistic theory (formal semantics) and cognitive psychology (e.g., studies of human reasoning). However, few studies in cognitive neuroscience have addressed logical dimensions of sentence-level language processing, and none have directly compared these aspects of processing with syntax and lexical/conceptual-semantics. We used ERPs to examine a violation paradigm involving “Negative Polarity Items” or NPIs (e.g., ever/any), which are sensitive to logical/truth-conditional properties of the environments in which they occur (e.g., presence/absence of negation in: John hasn’t ever been to Paris, versus: John has *ever been to Paris). Previous studies examining similar types of contrasts found a mix of effects on familiar ERP components (e.g., LAN, N400, P600). We argue that their experimental designs and/or analyses were incapable of separating which effects are connected to NPI-licensing violations proper. Our design enabled statistical analyses teasing apart genuine violation effects from independent effects tied solely to lexical/contextual factors. Here unlicensed NPIs elicited a late P600 followed in onset by a late left anterior negativity (or “L-LAN”), an ERP profile which has also appeared elsewhere in studies targeting logical semantics. Crucially, qualitatively distinct ERP-profiles emerged for syntactic and conceptual semantic violations which we also tested here. We discuss how these findings may be linked to previous findings in the ERP literature. Apart from methodological recommendations, we suggest that the study of logical semantics may aid advancing our understanding of the underlying neurocognitive etiology of ERP components. PMID:20138065

Competitive Semantic Memory Retrieval: Temporal Dynamics Revealed by Event-Related Potentials.

PubMed

Hellerstedt, Robin; Johansson, Mikael

2016-01-01

Memories compete for retrieval when they are related to a common retrieval cue. Previous research has shown that retrieval of a target memory may lead to subsequent retrieval-induced forgetting (RIF) of currently irrelevant competing memories. In the present study, we investigated the time course of competitive semantic retrieval and examined the neurocognitive mechanisms underlying RIF. We contrasted two theoretical accounts of RIF by examining a critical aspect of this memory phenomenon, namely the extent to which it depends on successful retrieval of the target memory. Participants first studied category-exemplar word-pairs (e.g. Fruit-Apple). Next, we recorded electrophysiological measures of brain activity while the participants performed a competitive semantic cued-recall task. In this task, the participants were provided with the studied categories but they were instructed to retrieve other unstudied exemplars (e.g. Fruit-Ma__?). We investigated the event-related potential (ERP) correlates of retrieval success by comparing ERPs from successful and failed retrieval trials. To isolate the ERP correlates of continuous retrieval attempts from the ERP correlates of retrieval success, we included an impossible retrieval condition, with incompletable word-stem cues (Drinks-Wy__) and compared it with a non-retrieval presentation baseline condition (Occupation-Dentist). The participants' memory for all the studied exemplars was tested in the final phase of the experiment. Taken together, the behavioural results suggest that RIF is independent of target retrieval. Beyond investigating the mechanisms underlying RIF, the present study also elucidates the temporal dynamics of semantic cued-recall by isolating the ERP correlates of retrieval attempt and retrieval success. The ERP results revealed that retrieval attempt is reflected in a late posterior negativity, possibly indicating construction of candidates for completing the word-stem cue and retrieval monitoring whereas retrieval success was reflected in an anterior positive slow wave.

Pinpointing the deficit in executive functions in adolescents with dyslexia performing the Wisconsin card sorting test: an ERP study.

PubMed

Horowitz-Kraus, Tzipi

2014-01-01

Adolescents with dyslexia exhibit well-established impairments in executive abilities. The Wisconsin card sorting test (WCST) is an executive test that yields surprisingly inconsistent results with this population. The current study aimed to shed light on the contradictory findings in the literature regarding the performance levels by individuals with dyslexia in WCST. We used a computerized-WCST (named the 'Madrid-Card Sorting Test') assessing executive functions using the Event-Related Potentials (ERPs) methodology. Adolescents with dyslexia exhibited a higher error rate and slower reaction times. This was most evident in the later trials of the series. However, differences in ERPs between the two groups were found only in the "target-locked" conditions, where individuals with dyslexia displayed decreased ERP components (N100, P300) compared to skilled readers. The changes between the groups in the "shift" compared to the "stay" conditions suggest the central role of working memory both in basic (e.g., shifting) and higher order (e.g., reading) processes in individuals with dyslexia. These findings suggest the central role of working memory both in basic (e.g., shifting) and higher order (e.g., reading) processes in individuals with dyslexia. The intact shifting mechanism and the working memory deficit may guide the building of more efficient intervention programs for individuals with dyslexia in the future.

Interaction of Erp Protein of Mycobacterium tuberculosis with Rv2212 Enhances Intracellular Survival of Mycobacterium smegmatis.

PubMed

Ganaie, Arsheed Ahmad; Trivedi, Garima; Kaur, Amanpreet; Jha, Sidharth Shankar; Anand, Shashi; Rana, Vibhuti; Singh, Amit; Kumar, Shekhar; Sharma, Charu

2016-10-15

The Mycobacterium tuberculosis exported repetitive protein (RvErp) is a crucial virulence-associated factor as determined by its role in the survival and multiplication of mycobacteria in cultured macrophages and in vivo Although attempts have been made to understand the function of Erp protein, its exact role in Mycobacterium pathogenesis is still elusive. One way to determine this is by searching for novel interactions of RvErp. Using a yeast two-hybrid assay, an adenylyl cyclase (AC), Rv2212, was found to interact with RvErp. The interaction between RvErp and Rv2212 is direct and occurs at the endogenous level. The Erp protein of Mycobacterium smegmatis (MSMEG_6405, or MsErp) interacts neither with Rv2212 nor with Ms_4279, the M. smegmatis homologue of Rv2212. Deletion mutants of Rv2212 revealed its adenylyl cyclase domain to be responsible for the interaction. RvErp enhances Rv2212-mediated cyclic AMP (cAMP) production. Also, the biological significance of the interaction between RvErp and Rv2212 was demonstrated by the enhanced survival of M. smegmatis within THP-1 macrophages. Taken together, these studies address a novel mechanism by which Erp executes its function. RvErp is one of the important virulence factors of M. tuberculosis This study describes a novel function of RvErp protein of M. tuberculosis by identifying Rv2212 as its interacting protein. Rv2212 is an adenylyl cyclase (AC) and produces cAMP, one of the prime second messengers that regulate the intracellular survival of mycobacteria. Therefore, the significance of investigating novel interactions of RvErp is paramount in unraveling the mechanisms governing the intracellular survival of mycobacteria. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Strategic enterprise resource planning in a health-care system using a multicriteria decision-making model.

PubMed

Lee, Chang Won; Kwak, N K

2011-04-01

This paper deals with strategic enterprise resource planning (ERP) in a health-care system using a multicriteria decision-making (MCDM) model. The model is developed and analyzed on the basis of the data obtained from a leading patient-oriented provider of health-care services in Korea. Goal criteria and priorities are identified and established via the analytic hierarchy process (AHP). Goal programming (GP) is utilized to derive satisfying solutions for designing, evaluating, and implementing an ERP. The model results are evaluated and sensitivity analyses are conducted in an effort to enhance the model applicability. The case study provides management with valuable insights for planning and controlling health-care activities and services.

A Comprehensive, Competency-Based Education Framework Using Medium-Sized ERP Systems

ERIC Educational Resources Information Center

Scholtz, Brenda; Cilliers, Charmain; Calitz, Andre

2012-01-01

Graduates with industry-relevant ERP competencies are highly sought after. This requirement is due to a dominance of Enterprise Resource Planning (ERP) systems and the positive affect which good quality ERP specialists have on the success rate of ERP system implementation projects. Universities are therefore increasingly pressurised to supply…

Electrophysiological quantification of underlying mechanism of decision making from auto dealers advertisement - A neuromarketing research

NASA Astrophysics Data System (ADS)

Samsuri, Norlyiana; Reza, Faruque; Begum, Tahamina; Yusoff, Nasir; Idris, Badrisyah; Omar, Hazim; Isa, Salmi Mohd

2016-10-01

This study focused on which display design of advertisement that would be able to attract most attention by measuring cognitive response and gaze behavior. Total of 15 subjects were recruited from USM undergraduate medical students. The event related potential (ERP) as a cognitive response during viewing different display design were recorded from 17 electrode sites using 128 electrode sensors net which was applied on the subject's scalp according to the 10-20 international electrode placement system. The amplitude of the evoked N100 and P300 ERP components were identified. To determine the statistical significance, amplitude data were analyzed using one way ANOVA test and reaction time was analyzed using Independent t-test. Two out of the 15 subjects participated in the ERP recording in order to measure the fixation duration, pupil size and attention maps of eye movement as a gaze behavioral response to the different display design using Eye Tracking. The ERP and the gaze behavior results were consistent. Higher amplitudes of the N100 and the P300 ERP components during the RLG view proved that participants had larger visual selective attention and visual cognitive processing during visual presentation of the RLG view. Visual interpretation of the attention map together with the fixation duration and the pupil size of gaze behavior data from two case studies revealed that the RLG view attracted more attention than its counterpart. In regards to color as a confounder, gaze performance data from two cases opened an interesting finding is that both subjects showed common interest in red color during both the LLG and the RLG view, indicating color may play a different role in the display design. The finding of this research has important information for the marketers to design their advertisement making it cost-effective and limited space advertising. And on that case, RLG view is the most prioritize display design.

Stimulus-to-matching-stimulus interval influences N1, P2, and P3b in an equiprobable Go/NoGo task.

PubMed

Steiner, Genevieve Z; Barry, Robert J; Gonsalvez, Craig J

2014-10-01

Previous research has shown that as the stimulus-to-matching-stimulus interval (including the target-to-target interval, TTI, and nontarget-to-nontarget interval, NNI) increases, the amplitude of the P300 ERP component increases systematically. Here, we extended previous P300 research and explored TTI and NNI effects on the various ERP components elicited in an auditory equiprobable Go/NoGo task. We also examined whether a similar mechanism was underpinning interval effects in early ERP components (e.g., N1). Thirty participants completed a specially-designed variable-ISI equiprobable task whilst their EEG activity was recorded. Component amplitudes were extracted using temporal PCA with unrestricted Varimax rotation. As expected, N1, P2, and P3b amplitudes increased as TTI and NNI increased, however, Processing Negativity (PN) and Slow Wave (SW) did not show the same systematic change with interval increments. To determine the origin of interval effects in sequential processing, a multiple regression analysis was conducted on each ERP component including stimulus type, interval, and all preceding components as predictors. These analyses showed that matching-stimulus interval predicted N1, P3b, and weakly predicted P2, but not PN or SW; SW was determined by P3b only. These results suggest that N1, P3b, and to some extent, P2, are affected by a similar temporal mechanism. However, the dissimilar pattern of results obtained for sequential ERP components indicates that matching-stimulus intervals are not affecting all aspects of stimulus processing. This argues against a global mechanism, such as a pathway-specific refractory effect, and suggests that stimulus processing is occurring in parallel pathways, some of which are not affected by temporal manipulations of matching-stimulus interval. Copyright © 2014 Elsevier B.V. All rights reserved.

Two stages of directed forgetting: Electrophysiological evidence from a short-term memory task.

PubMed

Gao, Heming; Cao, Bihua; Qi, Mingming; Wang, Jing; Zhang, Qi; Li, Fuhong

2016-06-01

In this study, a short-term memory test was used to investigate the temporal course and neural mechanism of directed forgetting under different memory loads. Within each trial, two memory items with high or low load were presented sequentially, followed by a cue indicating whether the presented items should be remembered. After an interval, subjects were asked to respond to the probe stimuli. The ERPs locked to the cues showed that (a) the effect of cue type was initially observed during the P2 (160-240 ms) time window, with more positive ERPs for remembering relative to forgetting cues; (b) load effects were observed during the N2-P3 (250-500 ms) time window, with more positive ERPs for the high-load than low-load condition; (c) the cue effect was also observed during the N2-P3 time window, with more negative ERPs for forgetting versus remembering cues. These results demonstrated that directed forgetting involves two stages: task-relevance identification and information discarding. The cue effects during the N2 epoch supported the view that directed forgetting is an active process. © 2016 Society for Psychophysiological Research.

Attitude toward money modulates outcome processing: an ERP study.

PubMed

Jia, Shiwei; Zhang, Wenxin; Li, Peng; Feng, Tingyong; Li, Hong

2013-01-01

Love of money (LOM) is concerned with the attitude toward money, which can be measured by the LOM scale through affective, behavioral, and cognitive dimensions. Research has observed that monetary attitude was tightly related to reward processing and could affect economic behavior. This study examined how monetary attitude modulated risky behavior and the underlying neural mechanisms of reward processing using event-related potential (ERP) technique. We compared both the risk level and brain responses of a high-level LOM (HLOM) group to a low-level LOM (LLOM) group using a simple gambling task. The behavioral results showed that the HLOM group was more risky than the LLOM group, particularly after loss. The feedback-related negativity (FRN) was measured as the difference wave (gain-related ERP was subtracted from loss-related ERP). The FRN difference wave was larger in the HLOM group than that in the LLOM group. The P3 in the HLOM group was more positive than that in the LLOM group. These results suggest that monetary attitude can modulate both the underlying neural mechanisms and behavioral performance in a reward-related task. The HLOM participants are more sensitive to gain/loss than the LLOM participants.

Music training and working memory: an ERP study.

PubMed

George, Elyse M; Coch, Donna

2011-04-01

While previous research has suggested that music training is associated with improvements in various cognitive and linguistic skills, the mechanisms mediating or underlying these associations are mostly unknown. Here, we addressed the hypothesis that previous music training is related to improved working memory. Using event-related potentials (ERPs) and a standardized test of working memory, we investigated both neural and behavioral aspects of working memory in college-aged, non-professional musicians and non-musicians. Behaviorally, musicians outperformed non-musicians on standardized subtests of visual, phonological, and executive memory. ERPs were recorded in standard auditory and visual oddball paradigms (participants responded to infrequent deviant stimuli embedded in lists of standard stimuli). Electrophysiologically, musicians demonstrated faster updating of working memory (shorter latency P300s) in both the auditory and visual domains and musicians allocated more neural resources to auditory stimuli (larger amplitude P300), showing increased sensitivity to the auditory standard/deviant difference and less effortful updating of auditory working memory. These findings demonstrate that long-term music training is related to improvements in working memory, in both the auditory and visual domains and in terms of both behavioral and ERP measures. Copyright © 2011 Elsevier Ltd. All rights reserved.

A novel BCI based on ERP components sensitive to configural processing of human faces

NASA Astrophysics Data System (ADS)

Zhang, Yu; Zhao, Qibin; Jing, Jin; Wang, Xingyu; Cichocki, Andrzej

2012-04-01

This study introduces a novel brain-computer interface (BCI) based on an oddball paradigm using stimuli of facial images with loss of configural face information (e.g., inversion of face). To the best of our knowledge, till now the configural processing of human faces has not been applied to BCI but widely studied in cognitive neuroscience research. Our experiments confirm that the face-sensitive event-related potential (ERP) components N170 and vertex positive potential (VPP) have reflected early structural encoding of faces and can be modulated by the configural processing of faces. With the proposed novel paradigm, we investigate the effects of ERP components N170, VPP and P300 on target detection for BCI. An eight-class BCI platform is developed to analyze ERPs and evaluate the target detection performance using linear discriminant analysis without complicated feature extraction processing. The online classification accuracy of 88.7% and information transfer rate of 38.7 bits min-1 using stimuli of inverted faces with only single trial suggest that the proposed paradigm based on the configural processing of faces is very promising for visual stimuli-driven BCI applications.

A novel BCI based on ERP components sensitive to configural processing of human faces.

PubMed

Zhang, Yu; Zhao, Qibin; Jin, Jing; Wang, Xingyu; Cichocki, Andrzej

2012-04-01

This study introduces a novel brain-computer interface (BCI) based on an oddball paradigm using stimuli of facial images with loss of configural face information (e.g., inversion of face). To the best of our knowledge, till now the configural processing of human faces has not been applied to BCI but widely studied in cognitive neuroscience research. Our experiments confirm that the face-sensitive event-related potential (ERP) components N170 and vertex positive potential (VPP) have reflected early structural encoding of faces and can be modulated by the configural processing of faces. With the proposed novel paradigm, we investigate the effects of ERP components N170, VPP and P300 on target detection for BCI. An eight-class BCI platform is developed to analyze ERPs and evaluate the target detection performance using linear discriminant analysis without complicated feature extraction processing. The online classification accuracy of 88.7% and information transfer rate of 38.7 bits min(-1) using stimuli of inverted faces with only single trial suggest that the proposed paradigm based on the configural processing of faces is very promising for visual stimuli-driven BCI applications.

Characterizing switching and congruency effects in the Implicit Association Test as reactive and proactive cognitive control.

PubMed

Hilgard, Joseph; Bartholow, Bruce D; Dickter, Cheryl L; Blanton, Hart

2015-03-01

Recent research has identified an important role for task switching, a cognitive control process often associated with executive functioning, in the Implicit Association Test (IAT). However, switching does not fully account for IAT effects, particularly when performance is scored using more recent d-score formulations. The current study sought to characterize multiple control processes involved in IAT performance through the use of event-related brain potentials (ERPs). Participants performed a race-evaluative IAT while ERPs were recorded. Behaviorally, participants experienced superadditive reaction time costs of incongruency and task switching, consistent with previous studies. The ERP showed a marked medial frontal negativity (MFN) 250-450 ms post-stimulus at midline fronto-central locations that were more negative for incongruent than congruent trials but more positive for switch than for no-switch trials, suggesting separable control processes are engaged by these two factors. Greater behavioral IAT bias was associated with both greater switch-related and congruency-related ERP activity. Findings are discussed in terms of the Dual Mechanisms of Control model of reactive and proactive cognitive control. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Synthetic event-related potentials: a computational bridge between neurolinguistic models and experiments.

PubMed

Barrès, Victor; Simons, Arthur; Arbib, Michael

2013-01-01

Our previous work developed Synthetic Brain Imaging to link neural and schema network models of cognition and behavior to PET and fMRI studies of brain function. We here extend this approach to Synthetic Event-Related Potentials (Synthetic ERP). Although the method is of general applicability, we focus on ERP correlates of language processing in the human brain. The method has two components: Phase 1: To generate cortical electro-magnetic source activity from neural or schema network models; and Phase 2: To generate known neurolinguistic ERP data (ERP scalp voltage topographies and waveforms) from putative cortical source distributions and activities within a realistic anatomical model of the human brain and head. To illustrate the challenges of Phase 2 of the methodology, spatiotemporal information from Friederici's 2002 model of auditory language comprehension was used to define cortical regions and time courses of activation for implementation within a forward model of ERP data. The cortical regions from the 2002 model were modeled using atlas-based masks overlaid on the MNI high definition single subject cortical mesh. The electromagnetic contribution of each region was modeled using current dipoles whose position and orientation were constrained by the cortical geometry. In linking neural network computation via EEG forward modeling to empirical results in neurolinguistics, we emphasize the need for neural network models to link their architecture to geometrically sound models of the cortical surface, and the need for conceptual models to refine and adopt brain-atlas based approaches to allow precise brain anchoring of their modules. The detailed analysis of Phase 2 sets the stage for a brief introduction to Phase 1 of the program, including the case for a schema-theoretic approach to language production and perception presented in detail elsewhere. Unlike Dynamic Causal Modeling (DCM) and Bojak's mean field model, Synthetic ERP builds on models of networks that mediate the relation between the brain's inputs, outputs, and internal states in executing a specific task. The neural networks used for Synthetic ERP must include neuroanatomically realistic placement and orientation of the cortical pyramidal neurons. These constraints pose exciting challenges for future work in neural network modeling that is applicable to systems and cognitive neuroscience. Copyright © 2012 Elsevier Ltd. All rights reserved.

Perceptual reversals during binocular rivalry: ERP components and their concomitant source differences.

PubMed

Britz, Juliane; Pitts, Michael A

2011-11-01

We used an intermittent stimulus presentation to investigate event-related potential (ERP) components associated with perceptual reversals during binocular rivalry. The combination of spatiotemporal ERP analysis with source imaging and statistical parametric mapping of the concomitant source differences yielded differences in three time windows: reversals showed increased activity in early visual (∼120 ms) and in inferior frontal and anterior temporal areas (∼400-600 ms) and decreased activity in the ventral stream (∼250-350 ms). The combination of source imaging and statistical parametric mapping suggests that these differences were due to differences in generator strength and not generator configuration, unlike the initiation of reversals in right inferior parietal areas. These results are discussed within the context of the extensive network of brain areas that has been implicated in the initiation, implementation, and appraisal of bistable perceptual reversals. Copyright © 2011 Society for Psychophysiological Research.

The Association between Aerobic Fitness and Language Processing in Children: Implications for Academic Achievement

PubMed Central

Scudder, Mark R.; Federmeier, Kara D.; Raine, Lauren B.; Direito, Artur; Boyd, Jeremy K.; Hillman, Charles H.

2014-01-01

Event-related brain potentials (ERPs) have been instrumental for discerning the relationship between children’s aerobic fitness and aspects of cognition, yet language processing remains unexplored. ERPs linked to the processing of semantic information (the N400) and the analysis of language structure (the P600) were recorded from higher and lower aerobically fit children as they read normal sentences and those containing semantic or syntactic violations. Results revealed that higher fit children exhibited greater N400 amplitude and shorter latency across all sentence types, and a larger P600 effect for syntactic violations. Such findings suggest that higher fitness may be associated with a richer network of words and their meanings, and a greater ability to detect and/or repair syntactic errors. The current findings extend previous ERP research explicating the cognitive benefits associated with greater aerobic fitness in children and may have important implications for learning and academic performance. PMID:24747513

Psychopathy, attention, and oddball target detection: New insights from PCL-R facet scores.

PubMed

Anderson, Nathaniel E; Steele, Vaughn R; Maurer, J Michael; Bernat, Edward M; Kiehl, Kent A

2015-09-01

Psychopathy is a disorder accompanied by cognitive deficits including abnormalities in attention. Prior studies examining cognitive features of psychopaths using ERPs have produced some inconsistent results. We examined psychopathy-related differences in ERPs during an auditory oddball task in a sample of incarcerated adult males. We extend previous work by deriving ERPs with principal component analysis (PCA) and relate these to the four facets of Hare's Psychopathy Checklist Revised (PCL-R). Features of psychopathy were associated with increased target N1 amplitude (facets 1, 4), decreased target P3 amplitude (facet 1), and reduced slow wave amplitude for frequent standard stimuli (facets 1, 3, 4). We conclude that employing PCA and examining PCL-R facets improve sensitivity and help clarify previously reported associations. Furthermore, attenuated slow wave during standards may be a novel marker for psychopaths' abnormalities in attention. © 2015 Society for Psychophysiological Research.

Mothers' multimodal information processing is modulated by multimodal interactions with their infants.

PubMed

Tanaka, Yukari; Fukushima, Hirokata; Okanoya, Kazuo; Myowa-Yamakoshi, Masako

2014-10-17

Social learning in infancy is known to be facilitated by multimodal (e.g., visual, tactile, and verbal) cues provided by caregivers. In parallel with infants' development, recent research has revealed that maternal neural activity is altered through interaction with infants, for instance, to be sensitive to infant-directed speech (IDS). The present study investigated the effect of mother- infant multimodal interaction on maternal neural activity. Event-related potentials (ERPs) of mothers were compared to non-mothers during perception of tactile-related words primed by tactile cues. Only mothers showed ERP modulation when tactile cues were incongruent with the subsequent words, and only when the words were delivered with IDS prosody. Furthermore, the frequency of mothers' use of those words was correlated with the magnitude of ERP differentiation between congruent and incongruent stimuli presentations. These results suggest that mother-infant daily interactions enhance multimodal integration of the maternal brain in parenting contexts.

Early and late brain signatures of emotional prosody among individuals with high versus low power.

PubMed

Paulmann, Silke; Uskul, Ayse K

2017-04-01

Using ERPs, we explored the relationship between social power and emotional prosody processing. In particular, we investigated differences at early and late processing stages between individuals primed with high or low power. Comparable to previously published findings from nonprimed participants, individuals primed with low power displayed differentially modulated P2 amplitudes in response to different emotional prosodies, whereas participants primed with high power failed to do so. Similarly, participants primed with low power showed differentially modulated amplitudes in response to different emotional prosodies at a later processing stage (late ERP component), whereas participants primed with high power did not. These ERP results suggest that high versus low power leads to emotional prosody processing differences at the early stage associated with emotional salience detection and at a later stage associated with more in-depth processing of emotional stimuli. © 2016 Society for Psychophysiological Research.

Mothers' multimodal information processing is modulated by multimodal interactions with their infants

PubMed Central

Tanaka, Yukari; Fukushima, Hirokata; Okanoya, Kazuo; Myowa-Yamakoshi, Masako

2014-01-01

Social learning in infancy is known to be facilitated by multimodal (e.g., visual, tactile, and verbal) cues provided by caregivers. In parallel with infants' development, recent research has revealed that maternal neural activity is altered through interaction with infants, for instance, to be sensitive to infant-directed speech (IDS). The present study investigated the effect of mother- infant multimodal interaction on maternal neural activity. Event-related potentials (ERPs) of mothers were compared to non-mothers during perception of tactile-related words primed by tactile cues. Only mothers showed ERP modulation when tactile cues were incongruent with the subsequent words, and only when the words were delivered with IDS prosody. Furthermore, the frequency of mothers' use of those words was correlated with the magnitude of ERP differentiation between congruent and incongruent stimuli presentations. These results suggest that mother-infant daily interactions enhance multimodal integration of the maternal brain in parenting contexts. PMID:25322936

Think "360"

ERIC Educational Resources Information Center

Ramaswami, Rama

2007-01-01

No longer do universities have to decide between off-the-shelf and custom programs, or between standalone constituent relationship management (CRM) applications and ERP-integrated solutions. Instead, today's mantra is "360"--an up-close, 360-degree view of student interactions. Whether the processes and technologies employed to achieve…

Local and Global Auditory Processing: Behavioral and ERP Evidence

PubMed Central

Sanders, Lisa D.; Poeppel, David

2007-01-01

Differential processing of local and global visual features is well established. Global precedence effects, differences in event-related potentials (ERPs) elicited when attention is focused on local versus global levels, and hemispheric specialization for local and global features all indicate that relative scale of detail is an important distinction in visual processing. Observing analogous differential processing of local and global auditory information would suggest that scale of detail is a general organizational principle of the brain. However, to date the research on auditory local and global processing has primarily focused on music perception or on the perceptual analysis of relatively higher and lower frequencies. The study described here suggests that temporal aspects of auditory stimuli better capture the local-global distinction. By combining short (40 ms) frequency modulated tones in series to create global auditory patterns (500 ms), we independently varied whether pitch increased or decreased over short time spans (local) and longer time spans (global). Accuracy and reaction time measures revealed better performance for global judgments and asymmetric interference that were modulated by amount of pitch change. ERPs recorded while participants listened to identical sounds and indicated the direction of pitch change at the local or global levels provided evidence for differential processing similar to that found in ERP studies employing hierarchical visual stimuli. ERP measures failed to provide evidence for lateralization of local and global auditory perception, but differences in distributions suggest preferential processing in more ventral and dorsal areas respectively. PMID:17113115

Neuromarkers of Post-Traumatic Stress Disorder (PTSD) in a patient after bilateral hand amputation - ERP case study.

PubMed

Chrapusta, Anna; Kropotov, Juri D; Pąchalska, Maria

2017-06-08

Introduction. There is a lack in the worldwide literature of reports on the Neuromarkers of Post-Traumatic Stress Disorder (PTSD) in patients after bilateral hand amputation The aim of this study was to test a hypothesis regarding developing Post-Traumatic Stress Disorder (PTSD) in a patient after bilateral hand amputation with the use of Event Related Potentials (ERPs). On the basis of previous research, the amplitudes of P3 ERP components elicited in the cued GO/NOGO tasks have been chosen as candidates for neuromarkers of PTSD. Case study. A 24-year-old patient had undergone bilateral hand amputation 12 months previously. The patient was repeatedly operated on (he had undergone successful bilateral hand replantation) and despite the severity of the injuries, he recovered. However, the patient complained of flashbacks, anxiety and sleep difficulties. Specialist tests showed the presence of PTSD. The patient participated in the cued GO/NOGO task (Kropotov, 2009) with recording 19-channel EEG. P3 GO and NOGO waves in this task were found to be significantly smaller, in comparison to a group of healthy control subjects of the same age (N=23) taken from the HBI normative database (https://www.hbimed.com/). This observed pattern of ERP waves in the patient corresponds to the pattern found in PTSD patients. Conclusions. ERPs in a GO/NOGO task can be used in the assessment of the functional brain changes induced by chronic PTSD.

Multivariate assessment of event-related potentials with the t-CWT method.

PubMed

Bostanov, Vladimir

2015-11-05

Event-related brain potentials (ERPs) are usually assessed with univariate statistical tests although they are essentially multivariate objects. Brain-computer interface applications are a notable exception to this practice, because they are based on multivariate classification of single-trial ERPs. Multivariate ERP assessment can be facilitated by feature extraction methods. One such method is t-CWT, a mathematical-statistical algorithm based on the continuous wavelet transform (CWT) and Student's t-test. This article begins with a geometric primer on some basic concepts of multivariate statistics as applied to ERP assessment in general and to the t-CWT method in particular. Further, it presents for the first time a detailed, step-by-step, formal mathematical description of the t-CWT algorithm. A new multivariate outlier rejection procedure based on principal component analysis in the frequency domain is presented as an important pre-processing step. The MATLAB and GNU Octave implementation of t-CWT is also made publicly available for the first time as free and open source code. The method is demonstrated on some example ERP data obtained in a passive oddball paradigm. Finally, some conceptually novel applications of the multivariate approach in general and of the t-CWT method in particular are suggested and discussed. Hopefully, the publication of both the t-CWT source code and its underlying mathematical algorithm along with a didactic geometric introduction to some basic concepts of multivariate statistics would make t-CWT more accessible to both users and developers in the field of neuroscience research.

Empirical models of scalp-EEG responses using non-concurrent intracranial responses

NASA Astrophysics Data System (ADS)

Kaur, Komalpreet; Shih, Jerry J.; Krusienski, Dean J.

2014-06-01

Objective. This study presents inter-subject models of scalp-recorded electroencephalographic (sEEG) event-related potentials (ERPs) using intracranially recorded ERPs from electrocorticography and stereotactic depth electrodes in the hippocampus, generally termed as intracranial EEG (iEEG). Approach. The participants were six patients with medically-intractable epilepsy that underwent temporary placement of intracranial electrode arrays to localize seizure foci. Participants performed one experimental session using a brain-computer interface matrix spelling paradigm controlled by sEEG prior to the iEEG electrode implantation, and one or more identical sessions controlled by iEEG after implantation. All participants were able to achieve excellent spelling accuracy using sEEG, four of the participants achieved roughly equivalent performance in the iEEG sessions, and all participants were significantly above chance accuracy for the iEEG sessions. The sERPs were modeled using a linear combination of iERPs using two different optimization criteria. Main results. The results indicate that sERPs can be accurately estimated from the iERPs for the patients that exhibited stable ERPs over the respective sessions, and that the transformed iERPs can be accurately classified with an sERP-derived classifier. Significance. The resulting models provide a new empirical representation of the formation and distribution of sERPs from underlying composite iERPs. These new insights provide a better understanding of ERP relationships and can potentially lead to the development of more robust signal processing methods for noninvasive EEG applications.

Static renewal tests using Anodonta imbecillis (freshwater mussels). Anodonta imbecillis QA test 1, Clinch River-Environmental Restoration Program (CR-ERP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1993-12-31

Toxicity testing of split whole sediment samples using juvenile freshwater mussels (Anodonta imbecillis) was conducted by TVA and CR-ERP personnel as part of the CR-ERP biomonitoring study of Clinch River sediments to provide a quality assurance mechanism for test organism quality and overall performance of the test. In addition, testing included procedures comparing daily renewal versus non-renewal of test sediments. Testing of sediment samples collected July 15 from Poplar Creek Miles 6.0 and 5.1 was conducted from July 21--30, 1993. Results from this test showed no toxicity (survival effects) to fresh-water mussels during a 9-day exposure to the sediments. Sidemore » by side testing of sediments with daily sediment renewal and no sediment renewal showed no differences between methods. This may be due to the absence of toxicity in both samples and may not reflect true differences between the two methods for toxic sediment. Attachments to this report include: Chain of custody forms -- originals; Toxicity test bench sheets and statistical analyses; and Ammonia analysis request and results.« less

Teaching Medium-Sized ERP Systems - A Problem-Based Learning Approach

NASA Astrophysics Data System (ADS)

Winkelmann, Axel; Matzner, Martin

In order to increase the diversity in IS education, we discuss an approach for teaching medium-sized ERP systems in master courses. Many of today's IS curricula are biased toward large ERP packages. Nevertheless, these ERP systems are only a part of the ERP market. Hence, this chapter describes a course outline for a course on medium-sized ERP systems. Students had to study, analyze, and compare five different ERP systems during a semester. The chapter introduces a procedure model and scenario for setting up similar courses at other universities. Furthermore, it describes some of the students' outcomes and evaluates the contribution of the course with regard to a practical but also academic IS education.

Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis

PubMed Central

2011-01-01

Despite the sparseness of the currently available data, there is accumulating evidence of information processing impairment in post-traumatic stress disorder (PTSD). Studies of event-related potentials (ERPs) are the main tool in real time examination of information processing. In this paper, we sought to critically review the ERP evidence of information processing abnormalities in patients with PTSD. We also examined the evidence supporting the existence of a relationship between ERP abnormalities and symptom profiles or severity in PTSD patients. An extensive Medline search was performed. Keywords included PTSD or post-traumatic stress disorder, electrophysiology or EEG, electrophysiology, P50, P100, N100, P2, P200, P3, P300, sensory gating, CNV (contingent negative variation) and MMN (mismatch negativity). We limited the review to ERP adult human studies with control groups which were reported in the English language. After applying our inclusion-exclusion review criteria, 36 studies were included. Subjects exposed to wide ranges of military and civilian traumas were studied in these reports. Presented stimuli were both auditory and visual. The most widely studied components included P300, P50 gating, N100 and P200. Most of the studies reported increased P300 response to trauma-related stimuli in PTSD patients. A smaller group of studies reported dampening of responses or no change in responses to trauma-related and/or unrelated stimuli. P50 studies were strongly suggestive of impaired gating in patients with PTSD. In conclusion, the majority of reports support evidence of information processing abnormalities in patients with PTSD diagnosis. The predominance of evidence suggests presence of mid-latency and late ERP components differences in PTSD patients in comparison to healthy controls. Heterogeneity of assessment methods used contributes to difficulties in reaching firm conclusions regarding the nature of these differences. We suggest that future ERP-PTSD studies utilize standardized assessment scales that provide detailed information regarding the symptom clusters and the degree of symptom severity. This would allow assessment of electrophysiological indices-clinical symptoms relationships. Based on the available data, we suggest that ERP abnormalities in PTSD are possibly affected by the level of illness severity. If supported by future research, ERP studies may be used for both initial assessment and treatment follow-up. PMID:22738160

Time-course of trigeminal versus olfactory stimulation: evidence from chemosensory evoked potentials.

PubMed

Flohr, Elena L R; Boesveldt, Sanne; Haehner, Antje; Iannilli, Emilia; Sinding, Charlotte; Hummel, Thomas

2015-03-01

Habituation of responses to chemosensory signals has been explored in many ways. Strong habituation and adaptation processes can be observed at the various levels of processing. For example, with repeated exposure, amplitudes of chemosensory event-related potentials (ERP) decrease over time. However, long-term habituation has not been investigated so far and investigations of differences in habituation between trigeminal and olfactory ERPs are very rare. The present study investigated habituation over a period of approximately 80 min for two olfactory and one trigeminal stimulus, respectively. Habituation was examined analyzing the N1 and P2 amplitudes and latencies of chemosensory ERPs and intensity ratings. It was shown that amplitudes of both components - and intensity ratings - decreased from the first to the last block. Concerning ERP latencies no effects of habituation were seen. Amplitudes of trigeminal ERPs diminished faster than amplitudes of olfactory ERPs, indicating that the habituation of trigeminal ERPs is stronger than habituation of olfactory ERPs. Amplitudes of trigeminal ERPs were generally higher than amplitudes of olfactory ERPs, as it has been shown in various studies before. The results reflect relatively selective central changes in response to chemosensory stimuli over time. Copyright © 2015 Elsevier B.V. All rights reserved.

Deployment of ERP Systems at Automotive Industries, Security Inspection (Case Study: IRAN KHODRO Automotive Company)

NASA Astrophysics Data System (ADS)

Ali, Hatamirad; Hasan, Mehrjerdi

Automotive industry and car production process is one of the most complex and large-scale production processes. Today, information technology (IT) and ERP systems incorporates a large portion of production processes. Without any integrated systems such as ERP, the production and supply chain processes will be tangled. The ERP systems, that are last generation of MRP systems, make produce and sale processes of these industries easier and this is the major factor of development of these industries anyhow. Today many of large-scale companies are developing and deploying the ERP systems. The ERP systems facilitate many of organization processes and make organization to increase efficiency. The security is a very important part of the ERP strategy at the organization, Security at the ERP systems, because of integrity and extensive, is more important of local and legacy systems. Disregarding of this point can play a giant role at success or failure of this kind of systems. The IRANKHODRO is the biggest automotive factory in the Middle East with an annual production over 600.000 cars. This paper presents ERP security deployment experience at the "IRANKHODRO Company". Recently, by launching ERP systems, it moved a big step toward more developments.

Prevalence and associated factors of early repolarization pattern in healthy young northeastern Thai men: A correlation study with Brugada electrocardiography

PubMed Central

Makarawate, Pattarapong; Chaosuwannakit, Narumol; Ruamcharoen, Yossavadee; Panthongviriyakul, Aunejit; Pongchaiyakul, Choowong; Tharaksa, Prapapan; Sripo, Temsiri; Sawanyawisuth, Kittisak

2015-01-01

Background Early repolarization pattern (ERP) is characterized by J-point elevation with QRS notching or slurring in the terminal portion of the QRS complex. It may be associated with sudden death. Brugada syndrome (BS) is a genetic and fatal disease commonly found in northeastern Thai men. Data on the rate and predictors of ERP in Asian populations are limited. In addition, the correlation between ERP and BS has never been studied in an endemic area of BS. This study aimed to evaluate the prevalence of ERP and its associated factors in young, healthy male Asian subjects. Methods Between June 2011 and May 2012, 282 young, healthy men aged 20–45 years were enrolled at check-up clinics in Khon Kaen, Thailand. Subjects were divided into the ERP and non-ERP groups. Results There were 29 subjects with ERP (10.3%). The Sokolow–Lyon index was an independent factor for ERP with an adjusted odds ratio of 1.090 (95% CI: 1.027, 1.159). The Brugada ECG pattern was found in 11 (37.9%) subjects in the ERP group. The Brugada ECG pattern (non-type 1) was commonly found in lateral ERP patients. After the placement of high intercostal leads, the Brugada ECG pattern was dramatically increased compared with results obtained during standard ECG lead placement. Conclusions The ERP rate in young, healthy men from northeastern Thailand was 10.3%. A higher Sokolow–Lyon index was the only independent factor associated with ERP. Subjects with ERP should be examined with high intercostal leads to uncover Brugada ECG. PMID:26336562

Modeling the effects of changes in New Source Review on national SO{sub 2} and NOx emissions from electricity-generating units

DOE Office of Scientific and Technical Information (OSTI.GOV)

David A. Evans; Benjamin F. Hobbs; Craig Oren

2007-03-15

The Clean Air Act establishes New Source Review (NSR) programs that apply to the construction or modification of major stationary emissions sources. In 2002 and 2003, the U.S. Environmental Protection Agency revised its rules to narrow the applicability of NSR to facility renovations. Congress then mandated a National Research Council study of the effects of the rules. An electricity-sector model - the Integrated Planning Model (IPM) - was used to explore the possible effects of the equipment replacement provision (ERP), the principal NSR change that was to affect the power-generation industry. The studies focused in particular on coal-fired electricity generatingmore » units, EGUs, for two reasons. First, coal-fired EGUs are important contributors of these pollutants, accounting for approximately 70 and 20% of nations SO{sub 2} and NOx emissions in 2004, respectively. Second, the shares of total capacity of large coal-fired EGUs that lack flue-gas desulfurization to control SO{sub 2} and selective catalytic reduction to reduce NOx emissions are 62 and 63% respectively. Although the analysis cannot predict effects on local emissions, assuming that the Clean Air Interstate Rule (CAIR) is implemented, we find that stringent enforcement of the previous NSR rules would likely lead to no or limited decreases in national emissions compared to policies such as ERP. Our results indicate that tighter emissions caps could achieve further decreases in national emissions more cost-effectively than NSR programs. 15 refs., 3 figs., 1 tab.« less

The effects of semantic congruency: a research of audiovisual P300-speller.

PubMed

Cao, Yong; An, Xingwei; Ke, Yufeng; Jiang, Jin; Yang, Hanjun; Chen, Yuqian; Jiao, Xuejun; Qi, Hongzhi; Ming, Dong

2017-07-25

Over the past few decades, there have been many studies of aspects of brain-computer interface (BCI). Of particular interests are event-related potential (ERP)-based BCI spellers that aim at helping mental typewriting. Nowadays, audiovisual unimodal stimuli based BCI systems have attracted much attention from researchers, and most of the existing studies of audiovisual BCIs were based on semantic incongruent stimuli paradigm. However, no related studies had reported that whether there is difference of system performance or participant comfort between BCI based on semantic congruent paradigm and that based on semantic incongruent paradigm. The goal of this study was to investigate the effects of semantic congruency in system performance and participant comfort in audiovisual BCI. Two audiovisual paradigms (semantic congruent and incongruent) were adopted, and 11 healthy subjects participated in the experiment. High-density electrical mapping of ERPs and behavioral data were measured for the two stimuli paradigms. The behavioral data indicated no significant difference between congruent and incongruent paradigms for offline classification accuracy. Nevertheless, eight of the 11 participants reported their priority to semantic congruent experiment, two reported no difference between the two conditions, and only one preferred the semantic incongruent paradigm. Besides, the result indicted that higher amplitude of ERP was found in incongruent stimuli based paradigm. In a word, semantic congruent paradigm had a better participant comfort, and maintained the same recognition rate as incongruent paradigm. Furthermore, our study suggested that the paradigm design of spellers must take both system performance and user experience into consideration rather than merely pursuing a larger ERP response.

The impact of symptomatic mild traumatic brain injury on complex everyday activities and the link with alterations in cerebral functioning: Exploratory case studies.

PubMed

Bottari, Carolina; Gosselin, Nadia; Chen, Jen-Kai; Ptito, Alain

2017-07-01

The objective of the study was to explore the neurophysiological correlates of altered functional independence using functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) after a mild traumatic brain injury (mTBI). The participants consisted of three individuals with symptomatic mTBI (3.9 ± 3.6 months post-mTBI) and 12 healthy controls. The main measures used were the Instrumental Activities of Daily Living (IADL) Profile observation-based assessment; a visual externally ordered working memory task combined to event-related potentials (ERP) and fMRI recordings; neuropsychological tests; post-concussion symptoms questionnaires; and the Activities of Daily Living (ADL) Profile interview. Compared to normal controls, all three patients had difficulty with a real-world complex budgeting activity due to deficits in planning, ineffective strategy use and/or a prolonged time to detect and correct errors. Reduced activations in the right mid-dorsolateral prefrontal cortex on fMRI as well as abnormal frontal or parietal components of the ERP occurred alongside these deficits. Results of this exploratory study suggest that reduced independence in complex everyday activities in symptomatic mTBI may be at least partly explained by a decrease in brain activation in the prefrontal cortex, abnormal ERP, or slower reaction times on working memory tasks. The study presents an initial attempt at combining research in neuroscience with ecological real-world evaluation research to further our understanding of the difficulties in complex everyday activities experienced by individuals with mTBI.

ERP correlates of processing the auditory consequences of own versus observed actions.

PubMed

Ghio, Marta; Scharmach, Katrin; Bellebaum, Christian

2018-06-01

Research has so far focused on neural mechanisms that allow us to predict the sensory consequences of our own actions, thus also contributing to ascribing them to ourselves as agents. Less attention has been devoted to processing the sensory consequences of observed actions ascribed to another human agent. Focusing on audition, there is consistent evidence of a reduction of the auditory N1 ERP for self- versus externally generated sounds, while ERP correlates of processing sensory consequences of observed actions are mainly unexplored. In a between-groups ERP study, we compared sounds generated by self-performed (self group) or observed (observation group) button presses with externally generated sounds, which were presented either intermixed with action-generated sounds or in a separate condition. Results revealed an overall reduction of the N1 amplitude for processing action- versus externally generated sounds in both the intermixed and the separate condition, with no difference between the groups. Further analyses, however, suggested that an N1 attenuation effect relative to the intermixed condition at frontal electrode sites might exist only for the self but not for the observation group. For both groups, we found a reduction of the P2 amplitude for processing action- versus all externally generated sounds. We discuss whether the N1 and the P2 reduction can be interpreted in terms of predictive mechanisms for both action execution and observation, and to what extent these components might reflect also the feeling of (self) agency and the judgment of agency (i.e., ascribing agency either to the self or to others). © 2017 Society for Psychophysiological Research.

47 CFR 74.796 - Modification of digital transmission systems and analog transmission systems for digital operation.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Subtract the value determined in the previous step from the authorized effective radiated power (“ERP”) of... ERP must be expressed in decibels above one kilowatt: ERP(dBk) = 10 log ERP(kW); (4) Convert the ERP calculated in the previous step to units of kilowatts; and (5) The ERP value determined through the above...

Treatment of obsessive-compulsive disorder complicated by comorbid eating disorders.

PubMed

Simpson, H Blair; Wetterneck, Chad T; Cahill, Shawn P; Steinglass, Joanna E; Franklin, Martin E; Leonard, Rachel C; Weltzin, Theodore E; Riemann, Bradley C

2013-01-01

Eating disorders and obsessive-compulsive disorder (OCD) commonly co-occur, but there is little data for how to treat these complex cases. To address this gap, we examined the naturalistic outcome of 56 patients with both disorders, who received a multimodal treatment program designed to address both problems simultaneously. A residential treatment program developed a cognitive-behavioral approach for patients with both OCD and an eating disorder by integrating exposure and response prevention (ERP) treatment for OCD with ERP strategies targeting eating pathology. Patients also received a supervised eating plan, medication management, and social support. At admission and discharge, patients completed validated measures of OCD severity (the Yale-Brown Obsessive-Compulsive Scale--Self Report [Y-BOCS-SR]), eating disorder severity (the Eating Disorders Examination-Questionnaire), and depressive severity (the Beck Depression Inventory II [BDI-II]). Body mass index (BMI) was also measured. Paired-sample t-tests examined change on these measures. Between 2006 and 2011, 56 individuals completed all study measures at admission and discharge. Mean length of stay was 57 days (SD = 27). Most (89%) were on psychiatric medications. Significant decreases were observed in OCD severity, eating disorder severity, and depression. Those with bulimia nervosa showed more improvement than those with anorexia nervosa. BMI significantly increased, primarily among those underweight at admission. Simultaneous treatment of OCD and eating disorders using a multimodal approach that emphasizes ERP techniques for both OCD and eating disorders can be an effective treatment strategy for these complex cases.

Pharmacogenetics-guided analgesics in major abdominal surgery: Further benefits within an enhanced recovery protocol.

PubMed

Senagore, Anthony J; Champagne, Bradley J; Dosokey, Eslam; Brady, Justin; Steele, Scott R; Reynolds, Harry L; Stein, Sharon L; Delaney, Conor P

2017-03-01

Effective, narcotic sparing analgesia is a major component of Enhanced Recovery Protocols (ERP), however the risk of poor analgesia and opioid related side effects (ORADE) remains an issue related to poor outcomes and satisfaction, and is strongly related to the risk of narcotic dependence after surgery. A variety of genes can impact narcotic and non-steroidal (NSAID) drug efficacy including: the CYP family (drug metabolism-narcotics and NSAID), or COMT/ABCB1/OPRM1 (functional receptor and transport activity for analgesia vs side effects). The purpose of this study was to perform the first assessment of the impact of a pharmacogenetics (PGx) guided selection of analgesics following major abdominal surgery within an ERP. A consecutive series of open and laparoscopic colorectal resections or major ventral hernia repair (PGx group) had a guided analgesic protocol based upon assessment of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, COMT, OPRM1, and ABCB1 genes. Study patients were compared to a recent historical series of patients (H group) managed using our well validated ERP. The primary outcome measure was the Overall Benefit of Analgesia Score (OBAS). Pain scores were also assessed. The data demonstrated a similar mix of procedures and gender between groups and more than half of the PGx group had revised analgesia from the standard ERP. The PGx group demonstrated significantly lower OBAS scores (p = 0.0.1) from POD1 (3.8 vs 5.4) through POD 5 (3.0 vs 4.5) Analgesia was also superior for the PGx group from POD1 through POD 5 (p = 0.04). Pharmacogenetics guidance resulted in frequent modifications of the analgesic program, resulting in excellent analgesia with a 50% reduction in narcotic consumption, and a reduced incidence of analgesic related side effects compared to our standard ERP. These data suggest further improvement in ERP resulting from a patient centric analgesic, reduced narcotic regimen which provides early and durable pain control with fewer narcotic related side effects. Copyright © 2016 Elsevier Inc. All rights reserved.

Environmental Baseline Survey, Real Property Transaction Between Nellis Air Force Base and the City of North Las Vegas for Construction of a Wastewater Treatment Facility, Clark County, Nevada. Phase 1

DTIC Science & Technology

2007-12-06

established action levels characterized pursuant to the Environmental Restoration Program (ERP) that is managed by the Restoration Program Manager (RPM) of...interviews are presented in Appendix E. Mr. D.J. Haarklau, 99 CES/CEVC, Environmental POLs Program Manager Mr. Haarklau provided GSRC with...Program Manager for 10 years, and according to a records search, no reportable spills have occurred within or in the vicinity of the subject property. He

Phase 1 Environmental Baseline Survey for the Acquisition of a Utility Easement by Clark County from Nellis Air Force Base, Clark County, Nevada

DTIC Science & Technology

2008-01-01

ERP) that is managed by the Restoration Program Manager (RPM) of the 99 CES/CEVR. Category 4 – Remedial action required and taken. Property where...are listed below and summaries of their interviews are presented in Appendix E. Mr. D.J. Haarklau, 99 CES/CEVC, Environmental POLs Program Manager ...Mr. Haarklau, who has been the POLs Program manager for 10 years, provided GSRC with information pertaining to reportable quantity spills that have

Effects of hand orientation on motor imagery--event related potentials suggest kinesthetic motor imagery to solve the hand laterality judgment task.

PubMed

Jongsma, Marijtje L A; Meulenbroek, Ruud G J; Okely, Judith; Baas, C Marjolein; van der Lubbe, Rob H J; Steenbergen, Bert

2013-01-01

Motor imagery (MI) refers to the process of imagining the execution of a specific motor action without actually producing an overt movement. Two forms of MI have been distinguished: visual MI and kinesthetic MI. To distinguish between these forms of MI we employed an event related potential (ERP) study to measure interference effects induced by hand orientation manipulations in a hand laterality judgement task. We hypothesized that this manipulation should only affect kinesthetic MI but not visual MI. The ERPs elicited by rotated hand stimuli contained the classic rotation related negativity (RRN) with respect to palm view stimuli. We observed that laterally rotated stimuli led to a more marked RRN than medially rotated stimuli. This RRN effect was observed when participants had their hands positioned in either a straight (control) or an inward rotated posture, but not when their hands were positioned in an outward rotated posture. Posture effects on the ERP-RRN have not previously been studied. Apparently, a congruent hand posture (hands positioned in an outward rotated fashion) facilitates the judgement of the otherwise more demanding laterally rotated hand stimuli. These ERP findings support a kinesthetic interpretation of MI involved in solving the hand laterality judgement task. The RRN may be used as a non-invasive marker for kinesthetic MI and seems useful in revealing the covert behavior of MI in e.g. rehabilitation programs.

Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer

PubMed Central

Chen, Shaohua; Zhang, Daohai

2015-01-01

The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as “friend or foe” in epithelial cancer. PMID:25709888

Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms.

PubMed

Lin, Yen-Feng; Chen, Chia-Yen; Öngür, Dost; Betensky, Rebecca; Smoller, Jordan W; Blacker, Deborah; Hall, Mei-Hua

2018-05-16

Event-related potential (ERP) components have been used to assess cognitive functions in patients with psychotic illness. Evidence suggests that among patients with psychosis there is a distinct heritable neurophysiologic phenotypic subtype captured by impairments across a range of ERP measures. In this study, we investigated the genetic basis of this "globally impaired" ERP cluster and its relationship to psychosis and cognitive abilities. We applied K-means clustering to six ERP measures to re-derive the globally impaired (n = 60) and the non-globally impaired ERP clusters (n = 323) in a sample of cases with schizophrenia (SCZ = 136) or bipolar disorder (BPD = 121) and healthy controls (n = 126). We used genome-wide association study (GWAS) results for SCZ, BPD, college completion, and childhood intelligence as the discovery datasets to derive polygenic risk scores (PRS) in our study sample and tested their associations with globally impaired ERP. We conducted mediation analyses to estimate the proportion of each PRS effect on severity of psychotic symptoms that is mediated through membership in the globally impaired ERP. Individuals with globally impaired ERP had significantly higher PANSS-positive scores (β = 3.95, P = 0.005). The SCZ-PRS was nominally associated with globally impaired ERP (unadjusted P = 0.01; R 2  = 3.07%). We also found a significant positive association between the college-PRS and globally impaired ERP (FDR-corrected P = 0.004; R 2  = 6.15%). The effect of college-PRS on PANSS positivity was almost entirely (97.1%) mediated through globally impaired ERP. These results suggest that the globally impaired ERP phenotype may represent some aspects of brain physiology on the path between genetic influences on educational attainment and psychotic symptoms.

Assimilation of enterprise technology upgrades: a factor-based study

NASA Astrophysics Data System (ADS)

Claybaugh, Craig C.; Ramamurthy, Keshavamurthy; Haseman, William D.

2017-02-01

The purpose of this study is to gain a better understanding of the differences in the propensity of firms to initiate and commit to the assimilation of an enterprise technology upgrade. A research model is proposed that examines the influences that four technological and four organisational factors have on predicting assimilation of a technology upgrade. Results show that firms with a greater propensity to assimilate the new enterprise resource planning (ERP) version have a higher assessment of relative advantage, IS technical competence, and the strategic role of IS relative to those firms with a lower propensity to assimilate a new ERP version.

Training and testing ERP-BCIs under different mental workload conditions

NASA Astrophysics Data System (ADS)

Ke, Yufeng; Wang, Peiyuan; Chen, Yuqian; Gu, Bin; Qi, Hongzhi; Zhou, Peng; Ming, Dong

2016-02-01

Objective. As one of the most popular and extensively studied paradigms of brain-computer interfaces (BCIs), event-related potential-based BCIs (ERP-BCIs) are usually built and tested in ideal laboratory settings in most existing studies, with subjects concentrating on stimuli and intentionally avoiding possible distractors. This study is aimed at examining the effect of simultaneous mental activities on ERP-BCIs by manipulating various levels of mental workload during the training and/or testing of an ERP-BCI. Approach. Mental workload was manipulated during the training or testing of a row-column P300-speller to investigate how and to what extent the spelling performance and the ERPs evoked by the oddball stimuli are affected by simultaneous mental workload. Main results. Responses of certain ERP components, temporal-occipital N200 and the late reorienting negativity evoked by the oddball stimuli and the classifiability of ERP features between targets and non-targets decreased with the increase of mental workload encountered by the subject. However, the effect of mental workload on the performance of ERP-BCI was not always negative but depended on the conditions where the ERP-BCI was built and applied. The performance of ERP-BCI built under an ideal lab setting without any irrelevant mental activities declined with the increasing mental workload of the testing data. However, the performance was significantly improved when an ERP-BCI was built under an appropriate mental workload level, compared to that built under speller-only conditions. Significance. The adverse effect of concurrent mental activities may present a challenge for ERP-BCIs trained in ideal lab settings but which are to be used in daily work, especially when users are performing demanding mental processing. On the other hand, the positive effects of the mental workload of the training data suggest that introducing appropriate mental workload during training ERP-BCIs is of potential benefit to the performance in practical applications.

ERP=Efficiency

ERIC Educational Resources Information Center

Violino, Bob

2008-01-01

This article discusses the enterprise resource planning (ERP) system. Deploying an ERP system is one of the most extensive--and expensive--IT projects a college or university can undertake. The potential benefits of ERP are significant: a more smoothly running operation with efficiencies in virtually every area of administration, from automated…

Synergistic nonuniform shortening of atrial refractory period induced by autonomic stimulation.

PubMed

Takei, M; Furukawa, Y; Narita, M; Ren, L M; Karasawa, Y; Murakami, M; Chiba, S

1991-12-01

We investigated the nonuniform effects of autonomic nerve stimulation of the effective refractory period (ERP) of the right atrium in the anesthetized dog. Stimulation of the discrete intracardiac sympathetic nerves to the sinoatrial (SA) nodal region uniformly shortened ERPs at three sites in the right atrium after administration of atropine. Right ansa subclavia (RS) stimulation similarly shortened ERPs in the absence of atropine. Stimulation of the discrete intracardiac parasympathetic nerves to the SA nodal region (SAP stimulation) shortened ERPs of the right atrium in a nonuniform manner. Simultaneous RS and SAP stimulation additively shortened ERPs at each site and decreased sinus rate much more than SAP stimulation alone. Shortening of ERP induced by SAP stimulation was greater than that induced by RS stimulation at similar absolute changes in heart rate. These results suggest that simultaneous activation of sympathetic and parasympathetic nerves nonuniformly shortens the ERP in the right atrium as the algebraic sum of the individual responses to each stimulation. However, parasympathetics exert the principal neural control over atrial ERP.

Event-related potential studies of outcome processing and feedback-guided learning.

PubMed

San Martín, René

2012-01-01

In order to control behavior in an adaptive manner the brain has to learn how some situations and actions predict positive or negative outcomes. During the last decade cognitive neuroscientists have shown that the brain is able to evaluate and learn from outcomes within a few hundred milliseconds of their occurrence. This research has been primarily focused on the feedback-related negativity (FRN) and the P3, two event-related potential (ERP) components that are elicited by outcomes. The FRN is a frontally distributed negative-polarity ERP component that typically reaches its maximal amplitude 250 ms after outcome presentation and tends to be larger for negative than for positive outcomes. The FRN has been associated with activity in the anterior cingulate cortex (ACC). The P3 (~300-600 ms) is a parietally distributed positive-polarity ERP component that tends to be larger for large magnitude than for small magnitude outcomes. The neural sources of the P3 are probably distributed over different regions of the cortex. This paper examines the theories that have been proposed to explain the functional role of these two ERP components during outcome processing. Special attention is paid to extant literature addressing how these ERP components are modulated by outcome valence (negative vs. positive), outcome magnitude (large vs. small), outcome probability (unlikely vs. likely), and behavioral adjustment. The literature offers few generalizable conclusions, but is beset with a number of inconsistencies across studies. This paper discusses the potential reasons for these inconsistencies and points out some challenges that probably will shape the field over the next decade.

Exposure and response prevention process predicts treatment outcome in youth with OCD.

PubMed

Kircanski, Katharina; Peris, Tara S

2015-04-01

Recent research on the treatment of adults with anxiety disorders suggests that aspects of the in-session exposure therapy process are relevant to clinical outcomes. However, few comprehensive studies have been conducted with children and adolescents. In the present study, 35 youth diagnosed with primary obsessive-compulsive disorder (OCD; M age = 12.9 years, 49% male, 63% Caucasian) completed 12 sessions of exposure and response prevention (ERP) in one of two treatment conditions as part of a pilot randomized controlled testing of a family focused intervention for OCD. Key exposure process variables, including youth self-reported distress during ERP and the quantity and quality of ERP completed, were computed. These variables were examined as predictors of treatment outcomes assessed at mid-treatment, post-treatment, and three-month follow-up, partialing treatment condition. In general, greater variability of distress during ERP and completing a greater proportion of combined exposures (i.e., exposures targeting more than one OC symptom at once) were predictive of better outcomes. Conversely, greater distress at the end of treatment was generally predictive of poorer outcomes. Finally, several variables, including within- and between-session decreases in distress during ERP, were not consistently predictive of outcomes. Findings signal potentially important facets of exposure for youth with OCD and have implications for treatment. A number of results also parallel recent findings in the adult literature, suggesting that there may be some continuity in exposure processes from child to adult development. Future work should examine additional measures of exposure process, such as psychophysiological arousal during exposure, in youth.

Your brain on bikes: P3, MMN/N2b, and baseline noise while pedaling a stationary bike.

PubMed

Scanlon, Joanna E M; Sieben, Alex J; Holyk, Kevin R; Mathewson, Kyle E

2017-06-01

Increasingly, there is a trend to measure brain activity in more ecologically realistic scenarios. Normally, the confines of the laboratory and sedentary tasks mitigate sources of electrical noise on EEG measurement. Moving EEG outside of the lab requires understanding of the impact of complex movements and activities on traditional EEG and ERP measures. Here, we recorded EEG with active electrodes while participants were either riding or sitting on a stationary bike in an electrical and sound-attenuated chamber in the lab. Participants performed an auditory oddball task, pressing a button when they detected rare target tones in a series of standard frequent tones. We quantified both the levels of spectral, single-trial baseline, and ERP baseline noise, as well as classic MMN/N2b and P3 ERP components measured during both biking and sitting still. We observed slight increases in posterior high frequency noise in the spectra, and increased noise in the baseline period during biking. However, morphologically and topographically similar MMN/N2b and P3 components were measured reliably while both biking and sitting. A quantification of the power to reliably measure ERPs as a function of the number of trials revealed slight increases in the number of trials needed during biking to achieve the same level of power. Taken in sum, our results confirm that classic ERPs can be measured reliably during biking activities in the lab. Future directions will employ these techniques outside the lab in ecologically valid situations. © 2017 Society for Psychophysiological Research.

Using ERP and WfM Systems for Implementing Business Processes: An Empirical Study

NASA Astrophysics Data System (ADS)

Aversano, Lerina; Tortorella, Maria

Software systems mainly considered from enterprises for dealing with a business process automation belong to the following two categories: Workflow Management Systems (WfMS) and Enterprise Resource Planning (ERP) systems. The wider diffusion of ERP systems tends to favourite this solution, but there are several limitations of most ERP systems for automating business processes. This paper reports an empirical study aiming at comparing the ability of implementing business processes of ERP systems and WfMSs. Two different case studies have been considered in the empirical study. It evaluates and analyses the correctness and completeness of the process models implemented by using ERP and WfM systems.

Electrical Neuroimaging of Music Processing Reveals Mid-Latency Changes with Level of Musical Expertise

PubMed Central

James, Clara E.; Oechslin, Mathias S.; Michel, Christoph M.; De Pretto, Michael

2017-01-01

This original research focused on the effect of musical training intensity on cerebral and behavioral processing of complex music using high-density event-related potential (ERP) approaches. Recently we have been able to show progressive changes with training in gray and white matter, and higher order brain functioning using (f)MRI [(functional) Magnetic Resonance Imaging], as well as changes in musical and general cognitive functioning. The current study investigated the same population of non-musicians, amateur pianists and expert pianists using spatio-temporal ERP analysis, by means of microstate analysis, and ERP source imaging. The stimuli consisted of complex musical compositions containing three levels of transgression of musical syntax at closure that participants appraised. ERP waveforms, microstates and underlying brain sources revealed gradual differences according to musical expertise in a 300–500 ms window after the onset of the terminal chords of the pieces. Within this time-window, processing seemed to concern context-based memory updating, indicated by a P3b-like component or microstate for which underlying sources were localized in the right middle temporal gyrus, anterior cingulate and right parahippocampal areas. Given that the 3 expertise groups were carefully matched for demographic factors, these results provide evidence of the progressive impact of training on brain and behavior. PMID:29163017

Automated single-trial assessment of laser-evoked potentials as an objective functional diagnostic tool for the nociceptive system.

PubMed

Hatem, S M; Hu, L; Ragé, M; Gierasimowicz, A; Plaghki, L; Bouhassira, D; Attal, N; Iannetti, G D; Mouraux, A

2012-12-01

To assess the clinical usefulness of an automated analysis of event-related potentials (ERPs). Nociceptive laser-evoked potentials (LEPs) and non-nociceptive somatosensory electrically-evoked potentials (SEPs) were recorded in 37 patients with syringomyelia and 21 controls. LEP and SEP peak amplitudes and latencies were estimated using a single-trial automated approach based on time-frequency wavelet filtering and multiple linear regression, as well as a conventional approach based on visual inspection. The amplitudes and latencies of normal and abnormal LEP and SEP peaks were identified reliably using both approaches, with similar sensitivity and specificity. Because the automated approach provided an unbiased solution to account for average waveforms where no ERP could be identified visually, it revealed significant differences between patients and controls that were not revealed using the visual approach. The automated analysis of ERPs characterized reliably and objectively LEP and SEP waveforms in patients. The automated single-trial analysis can be used to characterize normal and abnormal ERPs with a similar sensitivity and specificity as visual inspection. While this does not justify its use in a routine clinical setting, the technique could be useful to avoid observer-dependent biases in clinical research. Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Neural Correlates of Attentional Processing of Threat in Youth with and without Anxiety Disorders.

PubMed

Bechor, Michele; Ramos, Michelle L; Crowley, Michael J; Silverman, Wendy K; Pettit, Jeremy W; Reeb-Sutherland, Bethany C

2018-04-02

Late-stage attentional processing of threatening stimuli, quantified through event-related potentials (ERPs), differentiates youth with and without anxiety disorders. It is unknown whether early-stage attentional processing of threatening stimuli differentiates these groups. Examining both early and late stage attentional processes in youth may advance knowledge and enhance efforts to identify biomarkers for translational prevention and treatment research. Twenty-one youth with primary DSM-IV-TR anxiety disorders (10 males, ages 8-15 years) and 21 typically developing Controls (15 males, ages 8-16 years) completed a dot probe task while electroencephalography (EEG) was recorded, and ERPs were examined. Youth with anxiety disorders showed significantly larger (more positive) P1 amplitudes for threatening stimuli than for neutral stimuli, and Controls showed the opposite pattern. Youth with anxiety showed larger (more negative) N170 amplitudes compared with Controls. Controls showed significantly larger (more positive) P2 and P3 amplitudes, regardless of stimuli valence, compared with youth with anxiety disorders. ERPs observed during the dot probe task indicate youth with anxiety disorders display distinct neural processing during early stage attentional orienting and processing of faces; this was not the case for Controls. Such results suggest these ERP components may have potential as biomarkers of anxiety disorders in youth.

Effects of Pre-Encoding Stress on Brain Correlates Associated with the Long-Term Memory for Emotional Scenes

PubMed Central

Wirkner, Janine; Weymar, Mathias; Löw, Andreas; Hamm, Alfons O.

2013-01-01

Recent animal and human research indicates that stress around the time of encoding enhances long-term memory for emotionally arousing events but neural evidence remains unclear. In the present study we used the ERP old/new effect to investigate brain dynamics underlying the long-term effects of acute pre-encoding stress on memory for emotional and neutral scenes. Participants were exposed either to the Socially Evaluated Cold Pressure Test (SECPT) or a warm water control procedure before viewing 30 unpleasant, 30 neutral and 30 pleasant pictures. Two weeks after encoding, recognition memory was tested using 90 old and 90 new pictures. Emotional pictures were better recognized than neutral pictures in both groups and related to an enhanced centro-parietal ERP old/new difference (400–800 ms) during recognition, which suggests better recollection. Most interestingly, pre-encoding stress exposure specifically increased the ERP old/new-effect for emotional (unpleasant) pictures, but not for neutral pictures. These enhanced ERP/old new differences for emotional (unpleasant) scenes were particularly pronounced for those participants who reported high levels of stress during the SECPT. The results suggest that acute pre-encoding stress specifically strengthens brain signals of emotional memories, substantiating a facilitating role of stress on memory for emotional scenes. PMID:24039697

Electrical Neuroimaging of Music Processing Reveals Mid-Latency Changes with Level of Musical Expertise.

PubMed

James, Clara E; Oechslin, Mathias S; Michel, Christoph M; De Pretto, Michael

2017-01-01

This original research focused on the effect of musical training intensity on cerebral and behavioral processing of complex music using high-density event-related potential (ERP) approaches. Recently we have been able to show progressive changes with training in gray and white matter, and higher order brain functioning using (f)MRI [(functional) Magnetic Resonance Imaging], as well as changes in musical and general cognitive functioning. The current study investigated the same population of non-musicians, amateur pianists and expert pianists using spatio-temporal ERP analysis, by means of microstate analysis, and ERP source imaging. The stimuli consisted of complex musical compositions containing three levels of transgression of musical syntax at closure that participants appraised. ERP waveforms, microstates and underlying brain sources revealed gradual differences according to musical expertise in a 300-500 ms window after the onset of the terminal chords of the pieces. Within this time-window, processing seemed to concern context-based memory updating, indicated by a P3b-like component or microstate for which underlying sources were localized in the right middle temporal gyrus, anterior cingulate and right parahippocampal areas. Given that the 3 expertise groups were carefully matched for demographic factors, these results provide evidence of the progressive impact of training on brain and behavior.

47 CFR 73.525 - TV Channel 6 protection.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... (4) The maximum permissible effective radiated power (ERP) and antenna height may be adjusted for..., the maximum permissible vertically polarized ERP will be the maximum horizontally polarized ERP... it does not. (ii) If the applicant chooses to use mixed polarity, the permissible ERP is as follows...

Neural Patterns of the Implicit Association Test

PubMed Central

Healy, Graham F.; Boran, Lorraine; Smeaton, Alan F.

2015-01-01

The Implicit Association Test (IAT) is a reaction time based categorization task that measures the differential associative strength between bipolar targets and evaluative attribute concepts as an approach to indexing implicit beliefs or biases. An open question exists as to what exactly the IAT measures, and here EEG (Electroencephalography) has been used to investigate the time course of ERPs (Event-related Potential) indices and implicated brain regions in the IAT. IAT-EEG research identifies a number of early (250–450 ms) negative ERPs indexing early-(pre-response) processing stages of the IAT. ERP activity in this time range is known to index processes related to cognitive control and semantic processing. A central focus of these efforts has been to use IAT-ERPs to delineate the implicit and explicit factors contributing to measured IAT effects. Increasing evidence indicates that cognitive control (and related top-down modulation of attention/perceptual processing) may be components in the effective measurement of IAT effects, as factors such as physical setting or task instruction can change an IAT measurement. In this study we further implicate the role of proactive cognitive control and top-down modulation of attention/perceptual processing in the IAT-EEG. We find statistically significant relationships between D-score (a reaction-time based measure of the IAT-effect) and early ERP-time windows, indicating where more rapid word categorizations driving the IAT effect are present, they are at least partly explainable by neural activity not significantly correlated with the IAT measurement itself. Using LORETA, we identify a number of brain regions driving these ERP-IAT relationships notably involving left-temporal, insular, cingulate, medial frontal and parietal cortex in time regions corresponding to the N2- and P3-related activity. The identified brain regions involved with reduced reaction times on congruent blocks coincide with those of previous studies. PMID:26635570

Robust estimation of event-related potentials via particle filter.

PubMed

Fukami, Tadanori; Watanabe, Jun; Ishikawa, Fumito

2016-03-01

In clinical examinations and brain-computer interface (BCI) research, a short electroencephalogram (EEG) measurement time is ideal. The use of event-related potentials (ERPs) relies on both estimation accuracy and processing time. We tested a particle filter that uses a large number of particles to construct a probability distribution. We constructed a simple model for recording EEG comprising three components: ERPs approximated via a trend model, background waves constructed via an autoregressive model, and noise. We evaluated the performance of the particle filter based on mean squared error (MSE), P300 peak amplitude, and latency. We then compared our filter with the Kalman filter and a conventional simple averaging method. To confirm the efficacy of the filter, we used it to estimate ERP elicited by a P300 BCI speller. A 400-particle filter produced the best MSE. We found that the merit of the filter increased when the original waveform already had a low signal-to-noise ratio (SNR) (i.e., the power ratio between ERP and background EEG). We calculated the amount of averaging necessary after applying a particle filter that produced a result equivalent to that associated with conventional averaging, and determined that the particle filter yielded a maximum 42.8% reduction in measurement time. The particle filter performed better than both the Kalman filter and conventional averaging for a low SNR in terms of both MSE and P300 peak amplitude and latency. For EEG data produced by the P300 speller, we were able to use our filter to obtain ERP waveforms that were stable compared with averages produced by a conventional averaging method, irrespective of the amount of averaging. We confirmed that particle filters are efficacious in reducing the measurement time required during simulations with a low SNR. Additionally, particle filters can perform robust ERP estimation for EEG data produced via a P300 speller. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Beyond maximum speed—a novel two-stimulus paradigm for brain-computer interfaces based on event-related potentials (P300-BCI)

NASA Astrophysics Data System (ADS)

Kaufmann, Tobias; Kübler, Andrea

2014-10-01

Objective. The speed of brain-computer interfaces (BCI), based on event-related potentials (ERP), is inherently limited by the commonly used one-stimulus paradigm. In this paper, we introduce a novel paradigm that can increase the spelling speed by a factor of 2, thereby extending the one-stimulus paradigm to a two-stimulus paradigm. Two different stimuli (a face and a symbol) are presented at the same time, superimposed on different characters and ERPs are classified using a multi-class classifier. Here, we present the proof-of-principle that is achieved with healthy participants. Approach. Eight participants were confronted with the novel two-stimulus paradigm and, for comparison, with two one-stimulus paradigms that used either one of the stimuli. Classification accuracies (percentage of correctly predicted letters) and elicited ERPs from the three paradigms were compared in a comprehensive offline analysis. Main results. The accuracies slightly decreased with the novel system compared to the established one-stimulus face paradigm. However, the use of two stimuli allowed for spelling at twice the maximum speed of the one-stimulus paradigms, and participants still achieved an average accuracy of 81.25%. This study introduced an alternative way of increasing the spelling speed in ERP-BCIs and illustrated that ERP-BCIs may not yet have reached their speed limit. Future research is needed in order to improve the reliability of the novel approach, as some participants displayed reduced accuracies. Furthermore, a comparison to the most recent BCI systems with individually adjusted, rapid stimulus timing is needed to draw conclusions about the practical relevance of the proposed paradigm. Significance. We introduced a novel two-stimulus paradigm that might be of high value for users who have reached the speed limit with the current one-stimulus ERP-BCI systems.

[Exploration on Electroencephalogram Mechanism Differences of Negative Emotions Induced by Disgusted and Sad Situation Images].

PubMed

Wang, Xin; Jin, Jingna; Li, Song; Liu, Zhipeng; Yin, Tao

2015-12-01

Evolutionary psychology holds such an opinion that negative situation may threaten survival, trigger avoidance motive and have poor effects on the human-body function and the psychological quality. Both disgusted and sad situations can induce negative emotions. However, differences between the two situations on attention capture and emotion cognition during the emotion induction are still not well known. Typical disgusted and sad situation images were used in the present study to induce two negative emotions, and 15 young students (7 males and 8 females, aged 27 ± 3) were recruited in the experiments. Electroencephalogram of 32 leads was recorded when the subjects were viewing situation images, and event-related potentials (ERP) of all leads were obtained for future analysis. Paired sample t tests were carried out on two ERP signals separately induced by disgusted and sad situation images to get time quantum with significant statistical differences between the two ERP signals. Root-mean-square deviations of two ERP signals during each time quantum were calculated and the brain topographic map based on root-mean-square deviations was drawn to display differences of two ERP signals in spatial. Results showed that differences of ERP signals induced by disgusted and sad situation images were mainly manifested in T1 (120-450 ms) early and T2 (800-1,000 ms) later. During the period of T1, the occipital lobe reflecting attention capture was activated by both disgusted and sad situation images, but the prefrontal cortex reflecting emotion sense was activated only by disgusted situation images. During the period of T2, the prefrontal cortex was activated by both disgusted and sad situation images. However, the parietal lobe was activated only by disgusted situation images, which showed stronger emotional perception. The research results would have enlightenment to deepen understanding of negative emotion and to exploredeep cognitive neuroscience mechanisms of negative emotion induction.

Implementation of an enhanced recovery protocol in pediatric colorectal surgery.

PubMed

Short, Heather L; Heiss, Kurt F; Burch, Katelyn; Travers, Curtis; Edney, John; Venable, Claudia; Raval, Mehul V

2018-04-01

Enhanced recovery protocols (ERPs) have been shown to improve outcomes in adult surgical populations. Our purpose was to compare outcomes before and after implementation of an ERP in children undergoing elective colorectal surgery. A pediatric-specific colorectal ERP was developed and implemented at a single center starting in January 2015. A retrospective review was performed including 43 patients in the pre-ERP period (2012-2014) and 36 patients in the post-ERP period (2015-2016). Outcomes of interest included number of ERP interventions received, length of stay (LOS), complications, and readmissions. The median number of ERP interventions received per patient increased from 5 to 11 from 2012 to 2016. The median LOS decreased from 5days to 3days in the post-ERP period (p=0.01). We observed a simultaneous decrease in median time to regular diet, mean dose of narcotics, and mean volume of intraoperative fluids (p<0.001). The complication rate (21% vs. 17%, p=0.85) and 30-day readmission rate (23% vs. 11%, p=0.63) were not significantly different in the pre- and post-ERP periods. Implementation of a pediatric-specific ERP in children undergoing colorectal surgery is feasible, safe and may lead to improved outcomes. Further experience may highlight other opportunities for increased compliance and improved care. Treatment Study. Level III. Copyright © 2017 Elsevier Inc. All rights reserved.

Risk assessment for enterprise resource planning (ERP) system implementations: a fault tree analysis approach

NASA Astrophysics Data System (ADS)

Zeng, Yajun; Skibniewski, Miroslaw J.

2013-08-01

Enterprise resource planning (ERP) system implementations are often characterised with large capital outlay, long implementation duration, and high risk of failure. In order to avoid ERP implementation failure and realise the benefits of the system, sound risk management is the key. This paper proposes a probabilistic risk assessment approach for ERP system implementation projects based on fault tree analysis, which models the relationship between ERP system components and specific risk factors. Unlike traditional risk management approaches that have been mostly focused on meeting project budget and schedule objectives, the proposed approach intends to address the risks that may cause ERP system usage failure. The approach can be used to identify the root causes of ERP system implementation usage failure and quantify the impact of critical component failures or critical risk events in the implementation process.

An empirical identification and categorisation of training best practices for ERP implementation projects

NASA Astrophysics Data System (ADS)

Esteves, Jose Manuel

2014-11-01

Although training is one of the most cited critical success factors in Enterprise Resource Planning (ERP) systems implementations, few empirical studies have attempted to examine the characteristics of management of the training process within ERP implementation projects. Based on the data gathered from a sample of 158 respondents across four stakeholder groups involved in ERP implementation projects, and using a mixed method design, we have assembled a derived set of training best practices. Results suggest that the categorised list of ERP training best practices can be used to better understand training activities in ERP implementation projects. Furthermore, the results reveal that the company size and location have an impact on the relevance of training best practices. This empirical study also highlights the need to investigate the role of informal workplace trainers in ERP training activities.

Bootstrap Signal-to-Noise Confidence Intervals: An Objective Method for Subject Exclusion and Quality Control in ERP Studies

PubMed Central

Parks, Nathan A.; Gannon, Matthew A.; Long, Stephanie M.; Young, Madeleine E.

2016-01-01

Analysis of event-related potential (ERP) data includes several steps to ensure that ERPs meet an appropriate level of signal quality. One such step, subject exclusion, rejects subject data if ERP waveforms fail to meet an appropriate level of signal quality. Subject exclusion is an important quality control step in the ERP analysis pipeline as it ensures that statistical inference is based only upon those subjects exhibiting clear evoked brain responses. This critical quality control step is most often performed simply through visual inspection of subject-level ERPs by investigators. Such an approach is qualitative, subjective, and susceptible to investigator bias, as there are no standards as to what constitutes an ERP of sufficient signal quality. Here, we describe a standardized and objective method for quantifying waveform quality in individual subjects and establishing criteria for subject exclusion. The approach uses bootstrap resampling of ERP waveforms (from a pool of all available trials) to compute a signal-to-noise ratio confidence interval (SNR-CI) for individual subject waveforms. The lower bound of this SNR-CI (SNRLB) yields an effective and objective measure of signal quality as it ensures that ERP waveforms statistically exceed a desired signal-to-noise criterion. SNRLB provides a quantifiable metric of individual subject ERP quality and eliminates the need for subjective evaluation of waveform quality by the investigator. We detail the SNR-CI methodology, establish the efficacy of employing this approach with Monte Carlo simulations, and demonstrate its utility in practice when applied to ERP datasets. PMID:26903849

47 CFR 22.659 - Effective radiated power limits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... radiated power limits. The purpose of the rules in this section, which limit effective radiated power (ERP... subsequently relocated. (a) Maximum ERP. The ERP of base transmitters must not exceed 100 Watts under any circumstances. The ERP of mobile transmitters must not exceed 60 Watts under any circumstances. (b) Co-channel...

47 CFR 22.913 - Effective radiated power limits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... radiated power (ERP) of transmitters in the Cellular Radiotelephone Service must not exceed the limits in this section. (a) Maximum ERP. In general, the effective radiated power (ERP) of base transmitters and... areas, as those areas are defined in § 22.949, the ERP of base transmitters and cellular repeaters of...

Relationship of Event-Related Potentials to the Vigilance Decrement

PubMed Central

Haubert, Ashley; Walsh, Matt; Boyd, Rachel; Morris, Megan; Wiedbusch, Megan; Krusmark, Mike; Gunzelmann, Glenn

2018-01-01

Cognitive fatigue emerges in wide-ranging tasks and domains, but traditional vigilance tasks provide a well-studied context in which to explore the mechanisms underlying it. Though a variety of experimental methodologies have been used to investigate cognitive fatigue in vigilance, relatively little research has utilized electroencephalography (EEG), specifically event-related potentials (ERPs), to explore the nature of cognitive fatigue, also known as the vigilance decrement. Moreover, much of the research that has been done on vigilance and ERPs uses non-traditional vigilance paradigms, limiting generalizability to the established body of behavioral results and corresponding theories. In this study, we address concerns with prior research by (1) investigating the vigilance decrement using a well-established visual vigilance task, (2) utilizing a task designed to attenuate possible confounding ERP components present within a vigilance paradigm, and (3) informing our interpretations with recent findings from ERP research. We averaged data across electrodes located over the frontal, central, and parietal scalp. Then, we generated waveforms locked to the onset of critical low-frequency or non-critical high-frequency events during a 40 min task that was segregated into time blocks for data analysis. There were three primary findings from the analyses of these data. First, mean amplitude of N1 was greater during later blocks for both low-frequency and high-frequency events, a contradictory finding compared to past visual vigilance studies that is further discussed with respect to current interpretations of the N1 in visual attention tasks. Second, P3b mean amplitude following low-frequency events was reduced during later blocks, with a later onset latency. Third and finally, the decrease in P3b amplitude correlated with individual differences in the magnitude of the vigilance decrement, assessed using d′. The results provide evidence for degradations of cognitive processing efficiency brought on by extended time on task, leading to delayed processing and decreased discriminability of critical stimuli from non-critical stimuli. These conclusions are discussed in the context of the vigilance decrement and corresponding theoretical accounts. PMID:29559936

Effects of an Attachment-Based Intervention on Child Protective Services--Referred Mothers' Event-Related Potentials to Children's Emotions.

PubMed

Bernard, Kristin; Simons, Robert; Dozier, Mary

2015-01-01

This study examined the neurobiology of maternal sensitivity to children's emotions among mothers involved with Child Protective Services (CPS) and low-risk comparison mothers (M(age) = 31.6 years). CPS-referred mothers participated in the Attachment and Biobehavioral Catch-up (ABC) intervention or a control intervention. Mothers' event-related potentials (ERPs) were measured while they categorized images of children with crying, laughing, and neutral expressions. CPS-referred ABC mothers (n = 19) and low-risk comparison mothers (n = 30) showed a larger enhancement of ERP responses for emotional faces relative to neutral faces than CPS-referred control mothers (n = 21). Additionally, the magnitude of ERP responses to emotional faces was associated with observed maternal sensitivity. Findings add to the understanding of the neurobiology of deficits in parenting and suggest that these deficits are changeable through a parenting intervention. © 2015 The Authors. Child Development © 2015 Society for Research in Child Development, Inc.

Conflict-Specific Aging Effects Mainly Manifest in Early Information Processing Stages-An ERP Study with Different Conflict Types.

PubMed

Korsch, Margarethe; Frühholz, Sascha; Herrmann, Manfred

2016-01-01

Aging is usually accompanied by alterations of cognitive control functions such as conflict processing. Recent research suggests that aging effects on cognitive control seem to vary with degree and source of conflict, and conflict specific aging effects on performance measures as well as neural activation patterns have been shown. However, there is sparse information whether and how aging affects different stages of conflict processing as indicated by event related potentials (ERPs) such as the P2, N2 and P3 components. In the present study, 19 young and 23 elderly adults performed a combined Flanker conflict and stimulus-response-conflict (SRC) task. Analysis of the reaction times (RTs) revealed an increased SRC related conflict effect in elderly. ERP analysis furthermore demonstrated an age-related increase of the P2 amplitude in response to the SRC task. In addition, elderly adults exhibited an increased P3 amplitude modulation induced by incongruent SRC and Flanker conflict trials.

Intentional retrieval suppression can conceal guilty knowledge in ERP memory detection tests☆

PubMed Central

Bergström, Zara M.; Anderson, Michael C.; Buda, Marie; Simons, Jon S.; Richardson-Klavehn, Alan

2013-01-01

Brain-activity markers of guilty knowledge have been promoted as accurate and reliable measures for establishing criminal culpability. Tests based on these markers interpret the presence or absence of memory-related neural activity as diagnostic of whether or not incriminating information is stored in a suspect's brain. This conclusion critically relies on the untested assumption that reminders of a crime uncontrollably elicit memory-related brain activity. However, recent research indicates that, in some circumstances, humans can control whether they remember a previous experience by intentionally suppressing retrieval. We examined whether people could use retrieval suppression to conceal neural evidence of incriminating memories as indexed by Event-Related Potentials (ERPs). When people were motivated to suppress crime retrieval, their memory-related ERP effects were significantly decreased, allowing guilty individuals to evade detection. Our findings indicate that brain measures of guilty knowledge may be under criminals’ intentional control and place limits on their use in legal settings. PMID:23664804

Cross-language phonological activation: evidence from masked onset priming and ERPs.

PubMed

Jouravlev, Olessia; Lupker, Stephen J; Jared, Debra

2014-07-01

The goal of the present research was to provide direct evidence for the cross-language interaction of phonologies at the sub-lexical level by using the masked onset priming paradigm. More specifically, we investigated whether there is a cross-language masked onset priming effect (MOPE) with L2 (English) primes and L1 (Russian) targets and whether it is modulated by the orthographic similarity of primes and targets. Primes and targets had onsets that overlapped either only phonologically, only orthographically, both phonologically and orthographically, or did not have any overlap. Phonological overlap, but not orthographic overlap, between primes and targets led to faster naming latencies. In contrast, the ERP data provided evidence for effects of both phonological and orthographic overlap. Finally, the time-course of phonological and orthographic processing for our bilinguals mirrored the time-course previously reported for monolinguals in the ERP data. These results provide evidence for shared representations at the sub-lexical level for a bilingual's two languages. Copyright © 2014 Elsevier Inc. All rights reserved.

Control of a brain-computer interface using stereotactic depth electrodes in and adjacent to the hippocampus

NASA Astrophysics Data System (ADS)

Krusienski, D. J.; Shih, J. J.

2011-04-01

A brain-computer interface (BCI) is a device that enables severely disabled people to communicate and interact with their environments using their brain waves. Most research investigating BCI in humans has used scalp-recorded electroencephalography or intracranial electrocorticography. The use of brain signals obtained directly from stereotactic depth electrodes to control a BCI has not previously been explored. In this study, event-related potentials (ERPs) recorded from bilateral stereotactic depth electrodes implanted in and adjacent to the hippocampus were used to control a P300 Speller paradigm. The ERPs were preprocessed and used to train a linear classifier to subsequently predict the intended target letters. The classifier was able to predict the intended target character at or near 100% accuracy using fewer than 15 stimulation sequences in the two subjects tested. Our results demonstrate that ERPs from hippocampal and hippocampal adjacent depth electrodes can be used to reliably control the P300 Speller BCI paradigm.

The "electrophysiological sandwich": a method for amplifying ERP priming effects.

PubMed

Ktori, Maria; Grainger, Jonathan; Dufau, Stéphane; Holcomb, Phillip J

2012-08-01

We describe the results of a study that combines ERP recordings and sandwich priming, a variant of masked priming that provides a brief preview of the target prior to prime presentation (S. J. Lupker & C. J. Davis, 2009). This has been shown to increase the size of masked priming effects seen in behavioral responses. We found the same increase in sensitivity to ERP priming effects in an orthographic priming experiment manipulating the position of overlap of letters shared by primes and targets. Targets were 6-letter words and primes were formed of the 1st, 3rd, 4th, and 6th letters of targets in the related condition. Primes could be concatenated or hyphenated and could be centered on fixation or displaced by two letter spaces to the left or right. Priming effects with concatenated and/or displaced primes only started to emerge at 250 ms post-target onset, whereas priming effects from centrally located hyphenated primes emerged about 100 ms earlier. Copyright © 2012 Society for Psychophysiological Research.

On the effect of subliminal priming on subjective perception of images: a machine learning approach.

PubMed

Kumar, Parmod; Mahmood, Faisal; Mohan, Dhanya Menoth; Wong, Ken; Agrawal, Abhishek; Elgendi, Mohamed; Shukla, Rohit; Dauwels, Justin; Chan, Alice H D

2014-01-01

The research presented in this article investigates the influence of subliminal prime words on peoples' judgment about images, through electroencephalograms (EEGs). In this cross domain priming paradigm, the participants are asked to rate how much they like the stimulus images, on a 7-point Likert scale, after being subliminally exposed to masked lexical prime words, with EEG recorded simultaneously. Statistical analysis tools are used to analyze the effect of priming on behavior, and machine learning techniques to infer the primes from EEGs. The experiment reveals strong effects of subliminal priming on the participants' explicit rating of images. The subjective judgment affected by the priming makes visible change in event-related potentials (ERPs); results show larger ERP amplitude for the negative primes compared with positive and neutral primes. In addition, Support Vector Machine (SVM) based classifiers are proposed to infer the prime types from the average ERPs, which yields a classification rate of 70%.

The component structure of ERP subsequent memory effects in the Von Restorff paradigm and the word frequency effect in recall.

PubMed

Kamp, Siri-Maria; Brumback, Ty; Donchin, Emanuel

2013-11-01

We examined the degree to which ERP components elicited by items that are isolated from their context, either by their font size ("size isolates") or by their frequency of usage, are correlated with subsequent immediate recall. Study lists contained (a) 15 words including a size isolate, (b) 14 high frequency (HF) words with one low frequency word ("LF isolate"), or (c) 14 LF words with one HF word. We used spatiotemporal PCA to quantify ERP components. We replicated previously reported P300 subsequent memory effects for size isolates and found additional correlations with recall in the novelty P3, a right lateralized positivity, and a left lateralized slow wave that was distinct from the slow wave correlated with recall for nonisolates. LF isolates also showed evidence of a P300 subsequent memory effect and also elicited the left lateralized subsequent memory effect, supporting a role of distinctiveness in word frequency effects in recall. Copyright © 2013 Society for Psychophysiological Research.

Verbal predicates foster conscious recollection but not familiarity of a task-irrelevant perceptual feature--an ERP study.

PubMed

Ecker, Ullrich K H; Arend, Anna M; Bergström, Kirstin; Zimmer, Hubert D

2009-09-01

Research on the effects of perceptual manipulations on recognition memory has suggested that (a) recollection is selectively influenced by task-relevant information and (b) familiarity can be considered perceptually specific. The present experiment tested divergent assumptions that (a) perceptual features can influence conscious object recollection via verbal code despite being task-irrelevant and that (b) perceptual features do not influence object familiarity if study is verbal-conceptual. At study, subjects named objects and their presentation colour; this was followed by an old/new object recognition test. Event-related potentials (ERP) showed that a study-test manipulation of colour impacted selectively on the ERP effect associated with recollection, while a size manipulation showed no effect. It is concluded that (a) verbal predicates generated at study are potent episodic memory agents that modulate recollection even if the recovered feature information is task-irrelevant and (b) commonly found perceptual match effects on familiarity critically depend on perceptual processing at study.

Implicit conditioning of faces via the social regulation of emotion: ERP evidence of early attentional biases for security conditioned faces.

PubMed

Beckes, Lane; Coan, James A; Morris, James P

2013-08-01

Not much is known about the neural and psychological processes that promote the initial conditions necessary for positive social bonding. This study explores one method of conditioned bonding utilizing dynamics related to the social regulation of emotion and attachment theory. This form of conditioning involves repeated presentations of negative stimuli followed by images of warm, smiling faces. L. Beckes, J. Simpson, and A. Erickson (2010) found that this conditioning procedure results in positive associations with the faces measured via a lexical decision task, suggesting they are perceived as comforting. This study found that the P1 ERP was similarly modified by this conditioning procedure and the P1 amplitude predicted lexical decision times to insecure words primed by the faces. The findings have implications for understanding how the brain detects supportive people, the flexibility and modifiability of early ERP components, and social bonding more broadly. Copyright © 2013 Society for Psychophysiological Research.

Neural Manifestations of Implicit Self-Esteem: An ERP Study

PubMed Central

Wu, Lili; Cai, Huajian; Gu, Ruolei; Luo, Yu L. L.; Zhang, Jianxin; Yang, Jing; Shi, Yuanyuan; Ding, Lei

2014-01-01

Behavioral research has established that humans implicitly tend to hold a positive view toward themselves. In this study, we employed the event-related potential (ERP) technique to explore neural manifestations of positive implicit self-esteem using the Go/Nogo association task (GNAT). Participants generated a response (Go) or withheld a response (Nogo) to self or others words and good or bad attributes. Behavioral data showed that participants responded faster to the self paired with good than the self paired with bad, whereas the opposite proved true for others, reflecting the positive nature of implicit self-esteem. ERP results showed an augmented N200 over the frontal areas in Nogo responses relative to Go responses. Moreover, the positive implicit self-positivity bias delayed the onset time of the N200 wave difference between Nogo and Go trials, suggesting that positive implicit self-esteem is manifested on neural activity about 270 ms after the presentation of self-relevant stimuli. These findings provide neural evidence for the positivity and automaticity of implicit self-esteem. PMID:25006966

Emotions in word and face processing: early and late cortical responses.

PubMed

Schacht, Annekathrin; Sommer, Werner

2009-04-01

Recent research suggests that emotion effects in word processing resemble those in other stimulus domains such as pictures or faces. The present study aims to provide more direct evidence for this notion by comparing emotion effects in word and face processing in a within-subject design. Event-related brain potentials (ERPs) were recorded as participants made decisions on the lexicality of emotionally positive, negative, and neutral German verbs or pseudowords, and on the integrity of intact happy, angry, and neutral faces or slightly distorted faces. Relative to neutral and negative stimuli both positive verbs and happy faces elicited posterior ERP negativities that were indistinguishable in scalp distribution and resembled the early posterior negativities reported by others. Importantly, these ERP modulations appeared at very different latencies. Therefore, it appears that similar brain systems reflect the decoding of both biological and symbolic emotional signals of positive valence, differing mainly in the speed of meaning access, which is more direct and faster for facial expressions than for words.

Tracking the voluntary control of auditory spatial attention with event-related brain potentials.

PubMed

Störmer, Viola S; Green, Jessica J; McDonald, John J

2009-03-01

A lateralized event-related potential (ERP) component elicited by attention-directing cues (ADAN) has been linked to frontal-lobe control but is often absent when spatial attention is deployed in the auditory modality. Here, we tested the hypothesis that ERP activity associated with frontal-lobe control of auditory spatial attention is distributed bilaterally by comparing ERPs elicited by attention-directing cues and neutral cues in a unimodal auditory task. This revealed an initial ERP positivity over the anterior scalp and a later ERP negativity over the parietal scalp. Distributed source analysis indicated that the anterior positivity was generated primarily in bilateral prefrontal cortices, whereas the more posterior negativity was generated in parietal and temporal cortices. The anterior ERP positivity likely reflects frontal-lobe attentional control, whereas the subsequent ERP negativity likely reflects anticipatory biasing of activity in auditory cortex.

47 CFR 22.727 - Power limits for conventional rural radiotelephone transmitters.

Code of Federal Regulations, 2011 CFR

2011-10-01

... this section. (a) Maximum ERP. The effective radiated power (ERP) of central office and rural... circumstances. Frequency range (MHz) Maximum ERP (watts) 152-153 1400 157-159 150 454-455 3500 459-460 150 (b) Basic power limit. Except as provided in paragraph (d) of this section, the ERP of central office...

47 CFR 22.727 - Power limits for conventional rural radiotelephone transmitters.

Code of Federal Regulations, 2010 CFR

2010-10-01

... this section. (a) Maximum ERP. The effective radiated power (ERP) of central office and rural... circumstances. Frequency range (MHz) Maximum ERP (watts) 152-153 1400 157-159 150 454-455 3500 459-460 150 (b) Basic power limit. Except as provided in paragraph (d) of this section, the ERP of central office...

47 CFR 22.535 - Effective radiated power limits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... limits. The effective radiated power (ERP) of transmitters operating on the channels listed in § 22.531 must not exceed the limits in this section. (a) Maximum ERP. The ERP must not exceed the applicable limits in this paragraph under any circumstances. Frequency range (MHz) Maximum ERP (Watts) 35-36 600 43...

47 CFR 22.535 - Effective radiated power limits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... limits. The effective radiated power (ERP) of transmitters operating on the channels listed in § 22.531 must not exceed the limits in this section. (a) Maximum ERP. The ERP must not exceed the applicable limits in this paragraph under any circumstances. Frequency range (MHz) Maximum ERP (Watts) 35-36 600 43...

Is Open Source the ERP Cure-All?

ERIC Educational Resources Information Center

Panettieri, Joseph C.

2008-01-01

Conventional and hosted applications thrive, but open source ERP (enterprise resource planning) is coming on strong. In many ways, the evolution of the ERP market is littered with ironies. When Oracle began buying up customer relationship management (CRM) and ERP companies, some universities worried that they would be left with fewer choices and…

Minimal Information for Neural Electromagnetic Ontologies (MINEMO): A standards-compliant method for analysis and integration of event-related potentials (ERP) data

PubMed Central

Frishkoff, Gwen; Sydes, Jason; Mueller, Kurt; Frank, Robert; Curran, Tim; Connolly, John; Kilborn, Kerry; Molfese, Dennis; Perfetti, Charles; Malony, Allen

2011-01-01

We present MINEMO (Minimal Information for Neural ElectroMagnetic Ontologies), a checklist for the description of event-related potentials (ERP) studies. MINEMO extends MINI (Minimal Information for Neuroscience Investigations)to the ERP domain. Checklist terms are explicated in NEMO, a formal ontology that is designed to support ERP data sharing and integration. MINEMO is also linked to an ERP database and web application (the NEMO portal). Users upload their data and enter MINEMO information through the portal. The database then stores these entries in RDF (Resource Description Framework), along with summary metrics, i.e., spatial and temporal metadata. Together these spatial, temporal, and functional metadata provide a complete description of ERP data and the context in which these data were acquired. The RDF files then serve as inputs to ontology-based labeling and meta-analysis. Our ultimate goal is to represent ERPs using a rich semantic structure, so results can be queried at multiple levels, to stimulate novel hypotheses and to promote a high-level, integrative account of ERP results across diverse study methods and paradigms. PMID:22180824

Single-trial event-related potential extraction through one-unit ICA-with-reference

NASA Astrophysics Data System (ADS)

Lih Lee, Wee; Tan, Tele; Falkmer, Torbjörn; Leung, Yee Hong

2016-12-01

Objective. In recent years, ICA has been one of the more popular methods for extracting event-related potential (ERP) at the single-trial level. It is a blind source separation technique that allows the extraction of an ERP without making strong assumptions on the temporal and spatial characteristics of an ERP. However, the problem with traditional ICA is that the extraction is not direct and is time-consuming due to the need for source selection processing. In this paper, the application of an one-unit ICA-with-Reference (ICA-R), a constrained ICA method, is proposed. Approach. In cases where the time-region of the desired ERP is known a priori, this time information is utilized to generate a reference signal, which is then used for guiding the one-unit ICA-R to extract the source signal of the desired ERP directly. Main results. Our results showed that, as compared to traditional ICA, ICA-R is a more effective method for analysing ERP because it avoids manual source selection and it requires less computation thus resulting in faster ERP extraction. Significance. In addition to that, since the method is automated, it reduces the risks of any subjective bias in the ERP analysis. It is also a potential tool for extracting the ERP in online application.

Single-trial event-related potential extraction through one-unit ICA-with-reference.

PubMed

Lee, Wee Lih; Tan, Tele; Falkmer, Torbjörn; Leung, Yee Hong

2016-12-01

In recent years, ICA has been one of the more popular methods for extracting event-related potential (ERP) at the single-trial level. It is a blind source separation technique that allows the extraction of an ERP without making strong assumptions on the temporal and spatial characteristics of an ERP. However, the problem with traditional ICA is that the extraction is not direct and is time-consuming due to the need for source selection processing. In this paper, the application of an one-unit ICA-with-Reference (ICA-R), a constrained ICA method, is proposed. In cases where the time-region of the desired ERP is known a priori, this time information is utilized to generate a reference signal, which is then used for guiding the one-unit ICA-R to extract the source signal of the desired ERP directly. Our results showed that, as compared to traditional ICA, ICA-R is a more effective method for analysing ERP because it avoids manual source selection and it requires less computation thus resulting in faster ERP extraction. In addition to that, since the method is automated, it reduces the risks of any subjective bias in the ERP analysis. It is also a potential tool for extracting the ERP in online application.

Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration.

PubMed

Castillo, Valentina; Oñate, Maritza; Woehlbier, Ute; Rozas, Pablo; Andreu, Catherine; Medinas, Danilo; Valdés, Pamela; Osorio, Fabiola; Mercado, Gabriela; Vidal, René L; Kerr, Bredford; Court, Felipe A; Hetz, Claudio

2015-01-01

ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common neurodegenerative diseases downstream of the endoplasmic reticulum (ER) stress response. Despite accumulating correlative evidence supporting a neuroprotective role of ERp57, the contribution of this foldase to the physiology of the nervous system remains unknown. Here we developed a transgenic mouse model that overexpresses ERp57 in the nervous system under the control of the prion promoter. We analyzed the susceptibility of ERp57 transgenic mice to undergo neurodegeneration. Unexpectedly, ERp57 overexpression did not affect dopaminergic neuron loss and striatal denervation after injection of a Parkinson's disease-inducing neurotoxin. In sharp contrast, ERp57 transgenic animals presented enhanced locomotor recovery after mechanical injury to the sciatic nerve. These protective effects were associated with enhanced myelin removal, macrophage infiltration and axonal regeneration. Our results suggest that ERp57 specifically contributes to peripheral nerve regeneration, whereas its activity is dispensable for the survival of a specific neuronal population of the central nervous system. These results demonstrate for the first time a functional role of a component of the ER proteostasis network in peripheral nerve regeneration.

ERp29 controls invasion and metastasis of gastric carcinoma by inhibition of epithelial-mesenchymal transition via PI3K/Aktsignaling pathway.

PubMed

Ye, Jianxin; Huang, Jinsheng; Xu, Jie; Huang, Qiang; Wang, Jinzhou; Zhong, Wenjing; Lin, Xinjian; Li, Yun; Lin, Xu

2017-09-06

Gastric cancer (GC) accounts for the fourth most occurring malignancy and the third major cause of cancer death. Identifying novel molecular signaling pathways participating in gastric tumorigenesis and progression is pivotal for rational design of targeted therapies to improve advanced GC outcome. Recently, the endoplasmic reticulum (ER) protein 29 (ERp29) has been shown to inversely associate with primary tumor development and function as a tumor suppressor in breast cancer. However, the role of ERp29 in GC patients' prognosis and its function in GC progression is unknown. Clinical importance of ERp29 in the prognosis of GC patients was assessed by examining its expression in 148 GC tumor samples and correlation with clinicopathological characteristics and survival of the patients. The function and underlying mechanisms of ERp29 in GC growth, invasion and metastasis were explored both in vitro and in vivo. Downregulation of ERp29 was commonly found in GC tissues and highly correlated with more aggressive phenotypes and poorer prognosis. Functional assays demonstrated that knockdown of ERp29 increased GC cell migration and invasion and promoted metastasis. Conversely, ectopic overexpression of ERp29 produced opposite effects. Mechanistic studies revealed that loss of ERp29 induced an epithelial-to-mesenchymal transition (EMT) in the GC cells through activation of PI3K/Akt pathway signaling. These findings suggest that downregulation of ERp29 is probably one of the key molecular mechanisms responsible for the development and progression of GC.

Kernel PLS Estimation of Single-trial Event-related Potentials

NASA Technical Reports Server (NTRS)

Rosipal, Roman; Trejo, Leonard J.

2004-01-01

Nonlinear kernel partial least squaes (KPLS) regressior, is a novel smoothing approach to nonparametric regression curve fitting. We have developed a KPLS approach to the estimation of single-trial event related potentials (ERPs). For improved accuracy of estimation, we also developed a local KPLS method for situations in which there exists prior knowledge about the approximate latency of individual ERP components. To assess the utility of the KPLS approach, we compared non-local KPLS and local KPLS smoothing with other nonparametric signal processing and smoothing methods. In particular, we examined wavelet denoising, smoothing splines, and localized smoothing splines. We applied these methods to the estimation of simulated mixtures of human ERPs and ongoing electroencephalogram (EEG) activity using a dipole simulator (BESA). In this scenario we considered ongoing EEG to represent spatially and temporally correlated noise added to the ERPs. This simulation provided a reasonable but simplified model of real-world ERP measurements. For estimation of the simulated single-trial ERPs, local KPLS provided a level of accuracy that was comparable with or better than the other methods. We also applied the local KPLS method to the estimation of human ERPs recorded in an experiment on co,onitive fatigue. For these data, the local KPLS method provided a clear improvement in visualization of single-trial ERPs as well as their averages. The local KPLS method may serve as a new alternative to the estimation of single-trial ERPs and improvement of ERP averages.

The novel white spot syndrome virus-induced gene, PmERP15, encodes an ER stress-responsive protein in black tiger shrimp, Penaeus monodon.

PubMed

Leu, Jiann-Horng; Liu, Kuan-Fu; Chen, Kuan-Yu; Chen, Shu-Hwa; Wang, Yu-Bin; Lin, Chung-Yen; Lo, Chu-Fang

2015-04-01

By microarray screening, we identified a white spot syndrome virus (WSSV)-strongly induced novel gene in gills of Penaeus monodon. The gene, PmERP15, encodes a putative transmembrane protein of 15 kDa, which only showed some degree of similarity (54-59%) to several unknown insect proteins, but had no hits to shrimp proteins. RT-PCR showed that PmERP15 was highly expressed in the hemocytes, heart and lymphoid organs, and that WSSV-induced strong expression of PmERP15 was evident in all tissues examined. Western blot analysis likewise showed that WSSV strongly up-regulated PmERP15 protein levels. In WSSV-infected hemocytes, immunofluorescence staining showed that PmERP15 protein was colocalized with an ER enzyme, protein disulfide isomerase, and in Sf9 insect cells, PmERP15-EGFP fusion protein colocalized with ER -Tracker™ Red dye as well. GRP78, an ER stress marker, was found to be up-regulated in WSSV-infected P. monodon, and both PmERP15 and GRP78 were up-regulated in shrimp injected with ER stress inducers tunicamycin and dithiothreitol. Silencing experiments showed that although PmERP15 dsRNA-injected shrimp succumbed to WSSV infection more rapidly, the WSSV copy number had no significant changes. These results suggest that PmERP15 is an ER stress-induced, ER resident protein, and its induction in WSSV-infected shrimp is caused by the ER stress triggered by WSSV infection. Furthermore, although PmERP15 has no role in WSSV multiplication, its presence is essential for the survival of WSSV-infected shrimp. Copyright © 2014 Elsevier Ltd. All rights reserved.

Enhanced Recovery after Colorectal Surgery: Can We Afford Not to Use It?

PubMed

Jung, Andrew D; Dhar, Vikrom K; Hoehn, Richard S; Atkinson, Sarah J; Johnson, Bobby L; Rice, Teresa; Snyder, Jonathan R; Rafferty, Janice F; Edwards, Michael J; Paquette, Ian M

2018-04-01

Enhanced recovery pathways (ERPs) aim to reduce length of stay without adversely affecting short-term outcomes. High pharmaceutical costs associated with ERP regimens, however, remain a significant barrier to widespread implementation. We hypothesized that ERP would reduce hospital costs after elective colorectal resections, despite the use of more expensive pharmaceutical agents. An ERP was implemented in January 2016 at our institution. We collected data on consecutive colorectal resections for 1 year before adoption of ERP (traditional, n = 160) and compared them with consecutive resections after universal adoption of ERP (n = 146). Short-term surgical outcomes, total direct costs, and direct hospital pharmacy costs were compared between patients who received the ERP and those who did not. After implementation of the ERP, median length of stay decreased from 5.0 to 3.0 days (p < 0.01). There were no differences in 30-day complications (8.1% vs 8.9%) or hospital readmission (11.9% vs 11.0%). The ERP patients required significantly less narcotics during their index hospitalization (211.7 vs 720.2 morphine equivalence units; p < 0.01) and tolerated a regular diet 1 day sooner (p < 0.01). Despite a higher daily pharmacy cost ($477 per day vs $318 per day in the traditional cohort), the total direct pharmacy cost for the hospitalization was reduced in ERP patients ($1,534 vs $1,859; p = 0.016). Total direct cost was also lower in ERP patients ($9,791 vs $11,508; p = 0.004). Implementation of an ERP for patients undergoing elective colorectal resection substantially reduced length of stay, total hospital cost, and direct pharmacy cost without increasing complications or readmission rates. Enhanced recovery pathway after colorectal resection has both clinical and financial benefits. Widespread implementation has the potential for a dramatic impact on healthcare costs. Copyright © 2018 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

Data-driven region-of-interest selection without inflating Type I error rate.

PubMed

Brooks, Joseph L; Zoumpoulaki, Alexia; Bowman, Howard

2017-01-01

In ERP and other large multidimensional neuroscience data sets, researchers often select regions of interest (ROIs) for analysis. The method of ROI selection can critically affect the conclusions of a study by causing the researcher to miss effects in the data or to detect spurious effects. In practice, to avoid inflating Type I error rate (i.e., false positives), ROIs are often based on a priori hypotheses or independent information. However, this can be insensitive to experiment-specific variations in effect location (e.g., latency shifts) reducing power to detect effects. Data-driven ROI selection, in contrast, is nonindependent and uses the data under analysis to determine ROI positions. Therefore, it has potential to select ROIs based on experiment-specific information and increase power for detecting effects. However, data-driven methods have been criticized because they can substantially inflate Type I error rate. Here, we demonstrate, using simulations of simple ERP experiments, that data-driven ROI selection can indeed be more powerful than a priori hypotheses or independent information. Furthermore, we show that data-driven ROI selection using the aggregate grand average from trials (AGAT), despite being based on the data at hand, can be safely used for ROI selection under many circumstances. However, when there is a noise difference between conditions, using the AGAT can inflate Type I error and should be avoided. We identify critical assumptions for use of the AGAT and provide a basis for researchers to use, and reviewers to assess, data-driven methods of ROI localization in ERP and other studies. © 2016 Society for Psychophysiological Research.

Issues and considerations for using the scalp surface Laplacian in EEG/ERP research: A tutorial review

PubMed Central

Kayser, Jürgen; Tenke, Craig E.

2015-01-01

Despite the recognition that the surface Laplacian may counteract adverse effects of volume conduction and recording reference for surface potential data, electrophysiology as a discipline has been reluctant to embrace this approach for data analysis. The reasons for such hesitation are manifold but often involve unfamiliarity with the nature of the underlying transformation, as well as intimidation by a perceived mathematical complexity, and concerns of signal loss, dense electrode array requirements, or susceptibility to noise. We revisit the pitfalls arising from volume conduction and the mandated arbitrary choice of EEG reference, describe the basic principle of the surface Laplacian transform in an intuitive fashion, and exemplify the differences between common reference schemes (nose, linked mastoids, average) and the surface Laplacian for frequently-measured EEG spectra (theta, alpha) and standard event-related potential (ERP) components, such as N1 or P3. We specifically review common reservations against the universal use of the surface Laplacian, which can be effectively addressed by employing spherical spline interpolations with an appropriate selection of the spline flexibility parameter and regularization constant. We argue from a pragmatic perspective that not only are these reservations unfounded but that the continued predominant use of surface potentials poses a considerable impediment on the progress of EEG and ERP research. PMID:25920962

Acceptance and Success Factors for M-Learning of ERP Systems Curricula

ERIC Educational Resources Information Center

Scholtz, Brenda; Kapeso, Mando

2014-01-01

The effective training of users is a key factor of the success of Enterprise Resource Planning (ERP) system projects. This need for ERP system training is exacerbated by a demand for quality ERP consultants which is evident in Europe and in African countries, particularly in South Africa where science and technology education has been identified…

The influence of enterprise resource planning (ERP) systems' performance on earnings management

NASA Astrophysics Data System (ADS)

Tsai, Wen-Hsien; Lee, Kuen-Chang; Liu, Jau-Yang; Lin, Sin-Jin; Chou, Yu-Wei

2012-11-01

We analyse whether there is a linkage between performance measures of enterprise resource planning (ERP) systems and earnings management. We find that earnings management decreases with the higher performance of ERP systems. The empirical result is as expected. We further analyse how the dimension of the DeLone and McLean model of information systems success affects earnings management. We find that the relationship between the performance of ERP systems and earnings management depends on System Quality after ERP implementation. The more System Quality improves, the more earnings management is reduced.

ERP (enterprise resource planning) systems can streamline healthcare business functions.

PubMed

Jenkins, E K; Christenson, E

2001-05-01

Enterprise resource planning (ERP) software applications are designed to facilitate the systemwide integration of complex processes and functions across a large enterprise consisting of many internal and external constituents. Although most currently available ERP applications generally are tailored to the needs of the manufacturing industry, many large healthcare systems are investigating these applications. Due to the significant differences between manufacturing and patient care, ERP-based systems do not easily translate to the healthcare setting. In particular, the lack of clinical standardization impedes the use of ERP systems for clinical integration. Nonetheless, an ERP-based system can help a healthcare organization integrate many functions, including patient scheduling, human resources management, workload forecasting, and management of workflow, that are not directly dependent on clinical decision making.

Surgical Technical Evidence Review for Elective Total Joint Replacement Conducted for the AHRQ Safety Program for Improving Surgical Care and Recovery

PubMed Central

Siletz, Anaar E.; Singer, Emily S.; Faltermeier, Claire; Hu, Q. Lina; Ko, Clifford Y.; Golladay, Gregory J.; Kates, Stephen L.; Wick, Elizabeth C.; Maggard-Gibbons, Melinda

2018-01-01

Background: Use of enhanced recovery pathways (ERPs) can improve patient outcomes, yet national implementation of these pathways remains low. The Agency for Healthcare Research and Quality (AHRQ; funder), the American College of Surgeons, and the Johns Hopkins Medicine Armstrong Institute for Patent Safety and Quality have developed the Safety Program for Improving Surgical Care and Recovery—a national effort to catalyze implementation of practices to improve perioperative care and enhance recovery of surgical patients. This review synthesizes evidence that can be used to develop a protocol for elective total knee arthroplasty (TKA) and total hip arthroplasty (THA). Study Design: This review focuses on potential components of the protocol relevant to surgeons; anesthesia components are reported separately. Components were identified through review of existing pathways and from consultation with technical experts. For each, a structured review of MEDLINE identified systematic reviews, randomized trials, and observational studies that reported on these components in patients undergoing elective TKA/THA. This primary evidence review was combined with existing clinical guidelines in a narrative format. Results: Sixteen components were reviewed. Of the 10 preoperative components, most were focused on risk factor assessment including anemia, diabetes mellitus, tobacco use, obesity, nutrition, immune-modulating therapy, and opiates. Preoperative education, venous thromboembolism (VTE) prophylaxis, and bathing/Staphylococcus aureus decolonization were also included. The routine use of drains was the only intraoperative component evaluated. The 5 postoperative components included early mobilization, continuous passive motion, extended duration VTE prophylaxis, early oral alimentation, and discharge planning. Conclusion: This review synthesizes the evidence supporting potential surgical components of an ERP for elective TKA/THA. The AHRQ Safety Program for Improving Surgical Care and Recovery aims to guide hospitals and surgeons in identifying the best practices to implement in the surgical care of TKA and THA patients. PMID:29468091

ProcessGene-Connect: SOA Integration between Business Process Models and Enactment Transactions of Enterprise Software Systems

NASA Astrophysics Data System (ADS)

Wasser, Avi; Lincoln, Maya

In recent years, both practitioners and applied researchers have become increasingly interested in methods for integrating business process models and enterprise software systems through the deployment of enabling middleware. Integrative BPM research has been mainly focusing on the conversion of workflow notations into enacted application procedures, and less effort has been invested in enhancing the connectivity between design level, non-workflow business process models and related enactment systems such as: ERP, SCM and CRM. This type of integration is useful at several stages of an IT system lifecycle, from design and implementation through change management, upgrades and rollout. The paper presents an integration method that utilizes SOA for connecting business process models with corresponding enterprise software systems. The method is then demonstrated through an Oracle E-Business Suite procurement process and its ERP transactions.

Detection of deception: Event-related potential markers of attention and cognitive control during intentional false responses.

PubMed

Gibbons, Henning; Schnuerch, Robert; Wittinghofer, Christina; Armbrecht, Anne-Simone; Stahl, Jutta

2018-06-01

Successful deception requires the coordination of multiple mental processes, such as attention, conflict monitoring, and the regulation of emotion. We employed a simple classification task, assessing ERPs to further investigate the attentional and cognitive control components of (instructed) deception. In Experiment 1, 20 participants repeatedly categorized visually presented names of five animals and five plants. Prior to the experiment, however, each participant covertly selected one animal and one plant for deliberate misclassification. For these critical items, we observed significantly increased response times (RTs), error rates, and amplitudes of three ERP components: anterior P3a indicating the processing of task relevance, medial-frontal negativity reflecting conflict monitoring, and posterior P3b indicating sustained visual attention. In a blind identification of the individual critical words based on a priori defined criteria, an algorithm using two behavioral and two ERP measures combined showed a sensitivity of 0.73 and a specificity of 0.95, thus performing far above chance (0.2/0.2). Experiment 2 used five clothing and five furniture names and successfully replicated the findings of Experiment 1 in 25 new participants. For detection of the critical words, the algorithm from Experiment 1 was reused with only slight adjustments of the ERP time windows. This resulted in a very high detection performance (sensitivity 0.88, specificity 0.94) and significantly outperformed an algorithm based on RT alone. Thus, at least under controlled laboratory conditions, a highly accurate detection of instructed lies via the attentional and cognitive control components is feasible, and benefits strongly from combined behavioral and ERP measures. © 2017 Society for Psychophysiological Research.

Chemosensory event-related potentials in relation to side of stimulation, age, sex, and stimulus concentration.

PubMed

Stuck, B A; Frey, S; Freiburg, C; Hörmann, K; Zahnert, T; Hummel, T

2006-06-01

For chemosensory event-related potentials (ERP) significant effects of age and sex have been demonstrated. The aim of the present study was to assess the effects of stimulus concentration, side of stimulation, and sex on the topographical distribution of chemosensory ERP in a large group of subjects stratified for different age groups. In addition, psychophysical measures of both olfactory and trigeminal function should be assessed in greater detail compared to previous work. A total of 95 healthy subjects participated in the study. Olfactory functions were tested using the 'Sniffin' Sticks' comprising tests of odor identification, odor discrimination, and odor threshold. Trigeminal sensitivity was assessed on a psychophysical level using a lateralization paradigm. ERP to the olfactory stimulant H2S and the trigeminal irritant CO2 were recorded; stimuli were presented in different concentrations to the left and right nostril. Olfactory thresholds exhibited an age-related increase while the outcome of psychophysical trigeminal tests was not significantly affected by age. In contrast, there was no significant main effect of the factor 'sex' for olfactory tests, while women scored higher than men in the trigeminal task. ERP to olfactory and trigeminal stimuli exhibited a relationship to stimulus concentration, age, and sex with youngest women showing largest amplitudes and shortest latencies. There was no significant main effect of left- or right-sided stimulation on ERP. Measures of olfactory function were found to correlate with parameters of olfactory ERP even when controlling for the subject's age. In addition, correlations between scores in the lateralization task and parameters of the trigeminal ERP were found. Based on electrophysiological data obtained in a large sample size the present results established an age-related loss of olfactory and trigeminal function, which appears to be almost linear. Further, the present results emphasize that responses to chemosensory stimuli are related to sex, while the side of stimulation does not play a major role in the presently used paradigm. Finally, these data establish the lateralization paradigm as a psychophysical tool to investigate intranasal trigeminal function. The present results obtained in a representative group of healthy subjects establishes a comprehensive set of data, which will serve as reference for future work in this area of research.

The relation between race-related implicit associations and scalp-recorded neural activity evoked by faces from different races.

PubMed

He, Yi; Johnson, Marcia K; Dovidio, John F; McCarthy, Gregory

2009-01-01

The neural correlates of the perception of faces from different races were investigated. White participants performed a gender identification task in which Asian, Black, and White faces were presented while event-related potentials (ERPs) were recorded. Participants also completed an implicit association task for Black (IAT-Black) and Asian (IAT-Asian) faces. ERPs evoked by Black and White faces differed, with Black faces evoking a larger positive ERP that peaked at 168 ms over the frontal scalp, and White faces evoking a larger negative ERP that peaked at 244 ms. These Black/White ERP differences significantly correlated with participants' scores on the IAT-Black. ERPs also differentiated White from Asian faces and a significant correlation was obtained between the White-Asian ERP difference waves at approximately 500 ms and the IAT-Asian. A positive ERP at 116 ms over occipital scalp differentiated all three races, but was not correlated with either IAT. In addition, a late positive component (around 592 ms) was greater for the same race compared to either other race faces, suggesting potentially more extended or deeper processing of the same race faces. Taken together, the ERP/IAT correlations observed for both other races indicate the influence of a race-sensitive evaluative process that may include early more automatic and/or implicit processes and relatively later more controlled processes.

The Relation between Race-related Implicit Associations and Scalp-recorded Neural Activity Evoked by Faces from Different Races

PubMed Central

He, Yi; Johnson, Marcia K.; Dovidio, John F.; McCarthy, Gregory

2009-01-01

The neural correlates of the perception of faces from different races were investigated. White participants performed a gender identification task in which Asian, Black, and White faces were presented while event-related potentials (ERPs) were recorded. Participants also completed an implicit association task for Black (IAT-Black) and Asian (IAT-Asian) faces. ERPs evoked by Black and White faces differed, with Black faces evoking a larger positive ERP that peaked at 168 ms over the frontal scalp, and White faces evoking a larger negative ERP that peaked at 244 ms. These Black/White ERP differences significantly correlated with participants’ scores on the IAT-Black. ERPs also differentiated White from Asian faces and a significant correlation was obtained between the White-Asian ERP difference waves at ~500 ms and the IAT-Asian. A positive ERP at 116 ms over occipital scalp differentiated all three races, but was not correlated with either IAT. In addition, a late positive component (around 592 ms) was greater for the same race compared to either other race faces, suggesting potentially more extended or deeper processing of the same race faces. Taken together, the ERP/IAT correlations observed for both other races indicate the influence of a race-sensitive evaluative process that may include early more automatic and/or implicit processes and relatively later more controlled processes. PMID:19562628

Time will tell: A longitudinal investigation of brain-behavior relationships during reading development

DOE PAGES

Stites, Mallory C.; Laszlo, Sarah

2017-02-23

ERPs are a powerful tool for the study of reading, as they are both temporally precise and functionally specific. These are essential characteristics for studying a process that unfolds rapidly and consists of multiple, interactive subprocesses. In work with adults, clear, specific models exist linking components of the ERP with individual subprocesses of reading including orthographic decoding, phonological processing, and semantic access (e.g., Grainger & Holcomb, 2009). The relationships between ERP components and reading subprocesses are less clear in development; here, we address two questions regarding these relationships. First, we ask whether there are ERP markers that predict future readingmore » behaviors across a longitudinal year. Second, we ask whether any relationships observed between ERP components and reading behavior across time map onto the better-established relationships between ERPs and reading subprocesses in adults. To address these questions, we acquired ERPs from children engaging in a silent reading task and then, a year later, collected behavioral assessments of their reading ability. Finally, we find that ERPs collected in Year 1 do predict reading behaviors a year later. Further, we find that these relationships do conform, at least to some extent, to relationships between ERP components and reading subprocesses observed in adults, with, for example, N250 amplitude in Year 1 predicting phonological awareness in Year 2, and N400 amplitude in Year 1 predicting vocabulary in Year 2.« less

Time will tell: A longitudinal investigation of brain-behavior relationships during reading development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stites, Mallory C.; Laszlo, Sarah

ERPs are a powerful tool for the study of reading, as they are both temporally precise and functionally specific. These are essential characteristics for studying a process that unfolds rapidly and consists of multiple, interactive subprocesses. In work with adults, clear, specific models exist linking components of the ERP with individual subprocesses of reading including orthographic decoding, phonological processing, and semantic access (e.g., Grainger & Holcomb, 2009). The relationships between ERP components and reading subprocesses are less clear in development; here, we address two questions regarding these relationships. First, we ask whether there are ERP markers that predict future readingmore » behaviors across a longitudinal year. Second, we ask whether any relationships observed between ERP components and reading behavior across time map onto the better-established relationships between ERPs and reading subprocesses in adults. To address these questions, we acquired ERPs from children engaging in a silent reading task and then, a year later, collected behavioral assessments of their reading ability. Finally, we find that ERPs collected in Year 1 do predict reading behaviors a year later. Further, we find that these relationships do conform, at least to some extent, to relationships between ERP components and reading subprocesses observed in adults, with, for example, N250 amplitude in Year 1 predicting phonological awareness in Year 2, and N400 amplitude in Year 1 predicting vocabulary in Year 2.« less

Majority of Enterprise Resource Planning (ERP) Projects Fail--M-DCPS Is a Rare Exception. Information Capsule. Volume 1108

ERIC Educational Resources Information Center

Blazer, Christie

2012-01-01

A high percentage of ERP projects are classified as failures, leaving organizations with only partially functioning systems or, worse yet, with no ERP systems at all. Those that do succeed usually take significantly longer than expected and encounter staggering budget overruns. This Information Capsule summarizes 10 high profile ERP implementation…

Going with Best-of-Breed

ERIC Educational Resources Information Center

Ramaswami, Rama

2010-01-01

Back in the 1990s, enterprise resource planning (ERP) systems may not have been user-friendly, but what they tried to do was totally reasonable: replace stand-alone systems in various departments--such as finance, logistics, and human resources--with a single integrated software program. The idea was that although each department would still have…

Project Execution Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

DOE /NV

1999-03-22

Created in 1989 to address over 50 years of environmental liabilities arising out of nuclear weapons production and testing in the United States since World War II, the U.S. Department of Energy's (DOE's) Environmental Management (EM) Programs decade-long effort to reduce the costs of those environmental liabilities, collectively known as DOE's ''environmental mortgage,'' includes past as well as future cleanup costs associated with environmental contamination, hazardous and radioactive materials and wastes, contaminated buildings and facilities, and their associated risks. Tasked with the bulk of these cleanup efforts, the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's), Nevada Environmental Restoration Projectmore » (NV ERP) is attempting to complete applicable corrective actions at inactive contaminated sites and facilities managed by DOE/NV, while at the same time protecting human health and the environment. Regulated under the Federal Facility Agreement and Consent Order, the objectives of the NV ERP are to identify the nature and extent of the contamination, determine its potential risk to the public and the environment, and to perform the necessary corrective actions in compliance with this and other state and federal regulations, guidelines, and requirements. Associated with this vast effort are approximately 2,000 sites both on and off of the Nevada Test Site (NTS) that were used primarily for nuclear testing and are addressed in the NV ERP. This includes sites that were underground areas where tests were actually conducted, contaminated surface soils resulting from aboveground testing activities, and sites that supported other related testing hardware paraphenalia and/or NTS real estate properties (e.g., underground storage tanks, leachfields, landfills, contaminated waste areas, injection wells, muckpiles, and ponds). To assist in this effort, a NV ERP Team was assembled which is composed of organizations from both the public and private sectors. The strategy to be employed for environmental restoration is based on commonality of work and the DOE EM Program's vision to remediate the contaminated sites on a project-specific, site-by-site basis over an approximate ten-year period to be completed by the year 2006.« less

Electrophysiological Evidence for Domain-General Processes in Task-Switching

PubMed Central

Capizzi, Mariagrazia; Ambrosini, Ettore; Arbula, Sandra; Mazzonetto, Ilaria; Vallesi, Antonino

2016-01-01

The ability to flexibly switch between tasks is a hallmark of cognitive control. Despite previous studies that have investigated whether different task-switching types would be mediated by distinct or overlapping neural mechanisms, no definitive consensus has been reached on this question yet. Here, we aimed at directly addressing this issue by recording the event-related potentials (ERPs) elicited by two types of task-switching occurring in the context of spatial and verbal cognitive domains. Source analysis was also applied to the ERP data in order to track the spatial dynamics of brain activity underlying task-switching abilities. In separate blocks of trials, participants had to perform either spatial or verbal switching tasks both of which employed the same type of stimuli. The ERP analysis, which was carried out through a channel- and time-uninformed mass univariate approach, showed no significant differences between the spatial and verbal domains in the modulation of switch and repeat trials. Specifically, relative to repeat trials, switch trials in both domains were associated with a first larger positivity developing over left parieto-occipital electrodes and with a subsequent larger negativity distributed over mid-left fronto-central sites. The source analysis reconstruction for the two ERP components complemented these findings by highlighting the involvement of left-lateralized prefrontal areas in task-switching. Overall, our results join and extend recent research confirming the existence of left-lateralized domain-general task-switching processes. PMID:27047366

Spelling is Just a Click Away - A User-Centered Brain-Computer Interface Including Auto-Calibration and Predictive Text Entry.

PubMed

Kaufmann, Tobias; Völker, Stefan; Gunesch, Laura; Kübler, Andrea

2012-01-01

Brain-computer interfaces (BCI) based on event-related potentials (ERP) allow for selection of characters from a visually presented character-matrix and thus provide a communication channel for users with neurodegenerative disease. Although they have been topic of research for more than 20 years and were multiply proven to be a reliable communication method, BCIs are almost exclusively used in experimental settings, handled by qualified experts. This study investigates if ERP-BCIs can be handled independently by laymen without expert support, which is inevitable for establishing BCIs in end-user's daily life situations. Furthermore we compared the classic character-by-character text entry against a predictive text entry (PTE) that directly incorporates predictive text into the character-matrix. N = 19 BCI novices handled a user-centered ERP-BCI application on their own without expert support. The software individually adjusted classifier weights and control parameters in the background, invisible to the user (auto-calibration). All participants were able to operate the software on their own and to twice correctly spell a sentence with the auto-calibrated classifier (once with PTE, once without). Our PTE increased spelling speed and, importantly, did not reduce accuracy. In sum, this study demonstrates feasibility of auto-calibrating ERP-BCI use, independently by laymen and the strong benefit of integrating predictive text directly into the character-matrix.

The role of hunger state and dieting history in neural response to food cues: An event-related potential study.

PubMed

Feig, Emily H; Winter, Samantha R; Kounios, John; Erickson, Brian; Berkowitz, Staci A; Lowe, Michael R

2017-10-01

A history of dieting to lose weight has been shown to be a robust predictor of future weight gain. A potential factor in propensity towards weight gain is the nature of people's reactions to the abundance of highly palatable food cues in the environment. Event Related Potentials (ERPs) have revealed differences in how the brain processes food cues between obese and normal weight individuals, as well as between restrained and unrestrained eaters. However, comparisons by weight status are not informative regarding whether differences predate or follow weight gain in obese individuals and restrained eating has not consistently been found to predict future weight gain. The present study compared ERP responses to food cues in non-obese historic dieters (HDs) to non-obese never dieters (NDs). HDs showed a blunted N1 component relative to NDs overall, and delayed N1 and P2 components compared to NDs in the hungry state, suggesting that early, perceptual processing of food cues differs between these groups, especially when food-deprived. HDs also showed a more hunger-dependent sustained ERP (LPP) compared to NDs. Future research should test ERP-based food cue responsivity as a mediator between dieting history and future weight gain to better identify those most at risk for weight gain as well as the nature of their vulnerability. Copyright © 2017 Elsevier Inc. All rights reserved.

Electrophysiological evidence for strategically orienting retrieval toward the specific age of a memory.

PubMed

Johnson, Jeffrey D; McGhee, Anna K

2015-11-01

For over a century, memory researchers have extensively studied the differences between retrieving memories that were encoded in the remote past as opposed to recently. Although this work has largely focused on the changes that these memory traces undergo over time, an unexplored issue is whether retrieval attempts and other strategic processes might be differentially oriented in order to effectively access memories of different ages. The current study addressed this issue by instructing participants to retrieve words that were encoded either one week (remote) or about 30 minutes earlier (recent). To maximize the possibility that participants adopted distinct retrieval orientations, separate blocks of the memory test employed exclusion task procedures in which the words from only one encoding period were targeted at a given time, in the face of distractors from the other period. Event-related potentials (ERPs) elicited by correctly-rejected new items were contrasted to minimize confounding effects of retrieval success. The new-item ERPs revealed differences according to the targeted week, such that the ERPs over posterior scalp were more positive-going for the recent compared to remote blocks. Furthermore, using multiple methods, these ERP effects were dissociated from differences in difficulty across the two conditions. The findings provide novel evidence that knowledge about when a memory was initially encoded leads to differences in the adoption of retrieval processing strategies. Copyright © 2015 Elsevier Inc. All rights reserved.

Incorporating an ERP Project into Undergraduate Instruction

PubMed Central

Nyhus, Erika; Curtis, Nancy

2016-01-01

Electroencephalogram (EEG) is a relatively non-invasive, simple technique, and recent advances in open source analysis tools make it feasible to implement EEG as a component in undergraduate neuroscience curriculum. We have successfully led students to design novel experiments, record EEG data, and analyze event-related potentials (ERPs) during a one-semester laboratory course for undergraduates in cognitive neuroscience. First, students learned how to set up an EEG recording and completed an analysis tutorial. Students then learned how to set up a novel EEG experiment; briefly, they formed groups of four and designed an EEG experiment on a topic of their choice. Over the course of two weeks students collected behavioral and EEG data. Each group then analyzed their behavioral and ERP data and presented their results both as a presentation and as a final paper. Upon completion of the group project students reported a deeper understanding of cognitive neuroscience methods and a greater appreciation for the strengths and weaknesses of the EEG technique. Although recent advances in open source software made this project possible, it also required access to EEG recording equipment and proprietary software. Future efforts should be directed at making publicly available datasets to learn ERP analysis techniques and making publicly available EEG recording and analysis software to increase the accessibility of hands-on research experience in undergraduate cognitive neuroscience laboratory courses. PMID:27385925

Higher Education ERP: Lessons Learned.

ERIC Educational Resources Information Center

Swartz, Dave; Orgill, Ken

2001-01-01

Shares experiences and lessons learned by chief information officers of large universities about enterprise resource planning (ERP). Specifically, provides a framework for approaching an ERP that could save universities millions of dollars. (EV)

47 CFR 73.207 - Minimum distance separation between stations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... kW ERP and 100 meters antenna HAAT (or equivalent lower ERP and higher antenna HAAT based on a class... which have been notified internationally as Class A are limited to a maximum of 3.0 kW ERP at 100 meters... internationally as Class AA are limited to a maximum of 6.0 kW ERP at 100 meters HAAT, or the equivalent; (iii) U...

47 CFR 73.215 - Contour protection for short-spaced assignments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... station pursuant to 47 CFR 73.211(b)(3): 6 kW ERP/240 meters HAAT—Class A 25 kW ERP/150 meters HAAT—Class B1 50 kW ERP/472 meters HAAT—Class B (b) Applicants requesting short-spaced assignments pursuant to... achieved: (1) The ERP and antenna HAAT of the proposed station in the direction of the contours of other...

47 CFR 73.215 - Contour protection for short-spaced assignments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... station pursuant to 47 CFR 73.211(b)(3): 6 kW ERP/240 meters HAAT—Class A 25 kW ERP/150 meters HAAT—Class B1 50 kW ERP/472 meters HAAT—Class B (b) Applicants requesting short-spaced assignments pursuant to... achieved: (1) The ERP and antenna HAAT of the proposed station in the direction of the contours of other...

A Comparative Study of Average, Linked Mastoid, and REST References for ERP Components Acquired during fMRI

PubMed Central

Yang, Ping; Fan, Chenggui; Wang, Min; Li, Ling

2017-01-01

In simultaneous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) studies, average reference (AR), and digitally linked mastoid (LM) are popular re-referencing techniques in event-related potential (ERP) analyses. However, they may introduce their own physiological signals and alter the EEG/ERP outcome. A reference electrode standardization technique (REST) that calculated a reference point at infinity was proposed to solve this problem. To confirm the advantage of REST in ERP analyses of synchronous EEG-fMRI studies, we compared the reference effect of AR, LM, and REST on task-related ERP results of a working memory task during an fMRI scan. As we hypothesized, we found that the adopted reference did not change the topography map of ERP components (N1 and P300 in the present study), but it did alter the task-related effect on ERP components. LM decreased or eliminated the visual working memory (VWM) load effect on P300, and the AR distorted the distribution of VWM location-related effect at left posterior electrodes as shown in the statistical parametric scalp mapping (SPSM) of N1. ERP cortical source estimates, which are independent of the EEG reference choice, were used as the golden standard to infer the relative utility of different references on the ERP task-related effect. By comparison, REST reference provided a more integrated and reasonable result. These results were further confirmed by the results of fMRI activations and a corresponding EEG-only study. Thus, we recommend the REST, especially with a realistic head model, as the optimal reference method for ERP data analysis in simultaneous EEG-fMRI studies. PMID:28529472

Does the therapy manual or the therapist matter most in treatment of obsessive-compulsive disorder? A randomized controlled trial of exposure with response or ritual prevention in 118 patients.

PubMed

van Oppen, Patricia; van Balkom, Anton J L M; Smit, Johannes H; Schuurmans, Josien; van Dyck, Richard; Emmelkamp, Paul M G

2010-09-01

The importance of the therapist's education and experience for the successful behavior treatment of obsessive-compulsive disorder (OCD) has not been investigated. Data on the relative effectiveness of self-controlled versus therapist-controlled in vivo exposure with response or ritual prevention (ERP) have yielded conflicting results. The present study compared the effectiveness of 4 different modes of delivery of ERP in a referred sample of OCD patients. Of the 146 eligible OCD outpatients, 118 patients enrolled in this randomized controlled trial and were randomly assigned to (1) therapist-controlled ERP performed by experienced behavior therapists; (2) therapist-controlled ERP performed by master's students of clinical psychology; (3) self-controlled ERP performed by experienced behavior therapists; and (4) self-controlled ERP performed by master's students of clinical psychology. This trial was performed from January 1999 to January 2005. Our analyses revealed no significant differences in clinical outcome between any of the different modes of delivery of ERP at posttreatment. The different ERP modes of delivery were associated with significant pretreatment to posttreatment improvement on all measurements, with large effect sizes on the primary outcome measure, the Yale-Brown Obsessive Compulsive Scale. Our results indicate that clinically inexperienced master's students with no postgraduate training can be as capable as experienced and certified behavior therapists in treating OCD patients, as long as therapists adhere to a standardized treatment manual and adequate training and supervision is provided. In contrast to other studies, we did not find a supposed benefit of therapist-controlled ERP versus self-controlled ERP in patients with OCD. www.trialregister.nl Identifier: NTR1444. © Copyright 2010 Physicians Postgraduate Press, Inc.

A Comparative Study of Average, Linked Mastoid, and REST References for ERP Components Acquired during fMRI.

PubMed

Yang, Ping; Fan, Chenggui; Wang, Min; Li, Ling

2017-01-01

In simultaneous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) studies, average reference (AR), and digitally linked mastoid (LM) are popular re-referencing techniques in event-related potential (ERP) analyses. However, they may introduce their own physiological signals and alter the EEG/ERP outcome. A reference electrode standardization technique (REST) that calculated a reference point at infinity was proposed to solve this problem. To confirm the advantage of REST in ERP analyses of synchronous EEG-fMRI studies, we compared the reference effect of AR, LM, and REST on task-related ERP results of a working memory task during an fMRI scan. As we hypothesized, we found that the adopted reference did not change the topography map of ERP components (N1 and P300 in the present study), but it did alter the task-related effect on ERP components. LM decreased or eliminated the visual working memory (VWM) load effect on P300, and the AR distorted the distribution of VWM location-related effect at left posterior electrodes as shown in the statistical parametric scalp mapping (SPSM) of N1. ERP cortical source estimates, which are independent of the EEG reference choice, were used as the golden standard to infer the relative utility of different references on the ERP task-related effect. By comparison, REST reference provided a more integrated and reasonable result. These results were further confirmed by the results of fMRI activations and a corresponding EEG-only study. Thus, we recommend the REST, especially with a realistic head model, as the optimal reference method for ERP data analysis in simultaneous EEG-fMRI studies.

Evaluation of post-traumatic anosmia with MRI and chemosensory ERPs.

PubMed

Miao, Xutao; Yang, Ling; Gu, Hua; Ren, Yuanyuan; Chen, Guowei; Liu, Jia; Wei, Yongxiang

2015-08-01

Magnetic resonance imaging (MRI) and chemosensory event-related potentials (ERPs) are important methods to evaluate olfactory function, but there is lack of study to explore the application of MRI and chemosensory ERPs in the patients with traumatic anosmia. The data of 26 post-traumatic anosmic patients and 21 healthy controls were retrospectively surveyed; olfaction and olfactory pathway of all participants were measured clinically using the T&T olfactometer, the Sniffin' Sticks, chemosensory ERPs and MRI. All patients were anosmic based on complaints and clinical examinations. In five patients, the olfactory bulb volume was significantly lower than control group. In 18 patients, the olfactory sulcus (OS) depth was similar to control group, but all the participants had a deeper right OS (right = 7.79 ± 1.31, left = 7.06 ± 1.44, p < 0.01). Olfactory ERPs (oERPs) could be evoked in 17 patients, but these signals showed longer latencies and lower amplitude than controls in the N1 (latency p < 0.05, amplitude p < 0.01) and P2 (latency p < 0.01, amplitude p < 0.05) waves. Nine traumatic anosmic patients had no identifiable oERPs; most of them had olfactory center injury. Trigeminal ERPs were detected in all anosmic patients and controls; patients had longer latencies for N1 (p < 0.05) and P2 (p < 0.05) waves, while there was no similar change in amplitude. Older subjects had smaller OB volume and OS depth. Closed head injury could induce anosmia; the severity extent, injury site and subsequent consciousness are related to the olfaction. oERP is the gold standard for olfactory subjective examination; MRI could indicate the lesions on the olfactory pathway and reflect the possibility of detectable oERPs.

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer

PubMed Central

Samanta, Soma; Tamura, Shuzo; Dubeau, Louis; Mhawech-Fauceglia, Paulette; Miyagi, Yohei; Kato, Hisamori; Lieberman, Rich; Buckanovich, Ronald J.; Lin, Yvonne G.; Neamati, Nouri

2017-01-01

Objective Protein disulfide isomerase (PDI) is an oxidoreductase that is overexpressed in several cancers. PDI family members (PDIs) play a role in various diseases including cancer. Select PDIs were reported as useful markers in other cancers but their expression in ovarian cancer has not been thoroughly assessed. We sought to evaluate the expression of PDI, PDIA6, PDIR, ERp57, ERp72 and AGR3 in ovarian cancer patient samples and examine their prognostic significance. Methods TMA samples from 415 tissues collected from three cancer centers (UM, USC, and KCCRI) were used to assess the expression levels of PDI family proteins using IHC. Results We observed significant increases in PDI (p = 9.16E-36), PDIA6 (p = 5.51E-33), PDIR (p = 1.81E-12), ERp57 (p = 9.13E-07), ERp72 (p = 3.65E-22), and AGR3 (p = 4.56E-24) expression in ovarian cancers compared to normal tissues. Expression of PDI family members also increases during disease progression (p <0.001). All PDI family members are overexpressed in serous ovarian cancer (p<0.001). However, PDI, PDIA6, PDIR, ERp72 and AGR3 are more significantly overexpressed (p<0.001) than ERp57 (p<0.05) in clear cell ovarian carcinoma. Importantly, overexpression of PDI family members is associated with poor survival in ovarian cancer (p = 0.045 for PDI, p = 0.047 for PDIR, p = 0.037 for ERp57, p = 0.046 for ERp72, p = 0.040 for AGR3) with the exception of PDIA6 (p = 0.381). Conclusions Our findings demonstrate that select PDI family members (PDI, PDIR, ERp72, ERp57 and AGR3) are potential prognostic markers for ovarian cancer. PMID:29262583

47 CFR 22.867 - Effective radiated power limits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Effective radiated power limits. The effective radiated power (ERP) of ground and airborne stations... peak ERP of airborne mobile station transmitters must not exceed 12 Watts. (b) The peak ERP of ground...

Assessing ERP SAP implementation in the small and medium enterprises (SMEs) in Indonesia

NASA Astrophysics Data System (ADS)

Yohannes; Gunawan, W.; Ikhsan, R. B.; Aries

2018-03-01

The consistent growth of Indonesian SMEs has received attention of global IT vendors. One of major ERP player in Indonesian market such as SAP, has introduced ERP solutions for SMEs through SAP Business One. Due to its fast growth, unfortunately, there are still very few articles can be found to understand the ERP implementation in Indonesian SMEs. The article addressed the common factors that affect the successful of the ERP implementation at SMEs. They are: identifying vendor quality, opening balance data migration, and A-SAP methodology. The article applied case study method to examine the fast growth companies owned by same owners, such as: GRK, MMM, and KM25; with the objectives to identify the practical pattern of ERP implementation in SMEs that will be useful for SAP project manager and consultants.

A Mode of Combined ERP and KMS Knowledge Management System Construction

NASA Astrophysics Data System (ADS)

Yuena, Kang; Yangeng, Wen; Qun, Zhou

The core of ERP and knowledge management is quite similar; both will send appropriate knowledge (goods, funds) to the right people (position) at the right time. It is reasonable to believe that increase the knowledge management system in ERP will help companies achieve their goals better. This paper compares the concept of logical point of hall three-dimensional structure of the knowledge management system and the ERP in methodology level. And found they are very similar in the time dimension, logic dimension and knowledge dimension. This laid the basis of methodology in the simultaneous planning, implementation and applications. And then proposed a knowledge-based ERP Multi-Agent Management System Model. Finally, the paper described the process from planning to implementation of knowledge management ERP system with multi-Agent interaction and impact from three concepts, management thinking, software and system.

Probe-evoked event-related potential techniques for evaluating aspects of attention and information processing

NASA Technical Reports Server (NTRS)

Stern, John A.

1988-01-01

The study of probe event related potentials (probe ERPs) is reviewed. Several recent experiments are described which seem to leave in doubt the usefulness of applying ERP to simulation and field conditions as well as laboratory situations. Relatively minor changes in the experimental paradigm can produce major shifts in ERP findings, for reasons that are not clear. However, task-elicited ERPs might be used on a flight simulator if the experimenter takes time of arrival of the eyes on a particular instrument as one variable of concern and dwell time on the instrument as a second variable. One can then look at ERPs triggered by saccade termination for fixation pauses of specified durations. It may well be that ERP to a momentarily important display will differ from that elicited by routine instrument check.

Implementation of an Enhanced Recovery Pathway After Pancreaticoduodenectomy in Patients with Low Drain Fluid Amylase.

PubMed

Sutcliffe, Robert P; Hamoui, Majd; Isaac, John; Marudanayagam, Ravi; Mirza, Darius F; Muiesan, Paolo; Roberts, John K

2015-08-01

The safety and feasibility of an enhanced recovery pathway (ERP) after pancreatic surgery is largely unknown. Our aim was to prospectively evaluate a targeted ERP after pancreaticoduodenectomy (PD), using first postoperative day (POD) drain fluid amylase (DFA1) values to identify patients at low risk of pancreatic fistula (PF). Non-randomized cohort study of 130 consecutive patients. Perioperative outcomes were compared before (pre-ERP; N=65) and after (post-ERP; N=65) implementation of an ERP. Patients in each group were stratified according to the risk of PF using DFA1<350 IU/l. Low-risk patients in the post-ERP group were selected for early oral intake and early drain removal. 81/130 patients had a DFA1<350. Incidence of PF was significantly lower in low-risk patients (9 vs. 45%, P=0.0001). In low-risk patients, morbidity (43 vs. 36%) and mortality (2.7 vs. 4.5%) were similar for both pre- and post-ERP patients. Hospital stay (median 9 vs. 7 days, P=0.03) and 30-day readmissions (17 vs. 2%, P=0.04) were lower in low-risk patients in the post-ERP group. In high-risk patients, there was no difference in outcomes between pre- and post-ERP. Patients at low risk of PF after PD can be identified by first POD DFA1. Enhanced recovery after PD is safe and leads to improved short-term outcomes in low-risk patients.

Interactions between pre-processing and classification methods for event-related-potential classification: best-practice guidelines for brain-computer interfacing.

PubMed

Farquhar, J; Hill, N J

2013-04-01

Detecting event related potentials (ERPs) from single trials is critical to the operation of many stimulus-driven brain computer interface (BCI) systems. The low strength of the ERP signal compared to the noise (due to artifacts and BCI irrelevant brain processes) makes this a challenging signal detection problem. Previous work has tended to focus on how best to detect a single ERP type (such as the visual oddball response). However, the underlying ERP detection problem is essentially the same regardless of stimulus modality (e.g., visual or tactile), ERP component (e.g., P300 oddball response, or the error-potential), measurement system or electrode layout. To investigate whether a single ERP detection method might work for a wider range of ERP BCIs we compare detection performance over a large corpus of more than 50 ERP BCI datasets whilst systematically varying the electrode montage, spectral filter, spatial filter and classifier training methods. We identify an interesting interaction between spatial whitening and regularised classification which made detection performance independent of the choice of spectral filter low-pass frequency. Our results show that pipeline consisting of spectral filtering, spatial whitening, and regularised classification gives near maximal performance in all cases. Importantly, this pipeline is simple to implement and completely automatic with no expert feature selection or parameter tuning required. Thus, we recommend this combination as a "best-practice" method for ERP detection problems.

Aligning ERP systems with companies' real needs: an `Operational Model Based' method

NASA Astrophysics Data System (ADS)

Mamoghli, Sarra; Goepp, Virginie; Botta-Genoulaz, Valérie

2017-02-01

Enterprise Resource Planning (ERP) systems offer standard functionalities that have to be configured and customised by a specific company depending on its own requirements. A consistent alignment is therefore an essential success factor of ERP projects. To manage this alignment, an 'Operational Model Based' method is proposed. It is based on the design and the matching of models, and conforms to the modelling views and constructs of the ISO 19439 and 19440 enterprise-modelling standards. It is characterised by: (1) a predefined design and matching order of the models; (2) the formalisation, in terms of modelling constructs, of alignment and misalignment situations; and (3) their association with a set of decisions in order to mitigate the misalignment risk. Thus, a comprehensive understanding of the alignment management during ERP projects is given. Unlike existing methods, this one includes decisions related to the organisational changes an ERP system can induce, as well as criteria on which the best decision can be based. In this way, it provides effective support and guidance to companies implementing ERP systems, as the alignment process is detailed and structured. The method is applied on the ERP project of a Small and Medium Enterprise, showing that it can be used even in contexts where the ERP project expertise level is low.

Enhanced recovery protocol: implementation at a county institution with limited resources.

PubMed

Rona, Kais; Choi, J; Sigle, G; Kidd, S; Ault, G; Senagore, A J

2012-10-01

The benefits of an enhanced recovery protocol (ERP) in colorectal surgery have been well described; however, data on the implementation process is minimal, especially in a resource-limited institution. The purpose of this study was to evaluate outcomes during implementation of a physician-driven ERP at a public-funded institution. We retrospectively reviewed all elective colorectal surgery during a transition from standard care to an ERP (implemented via a standard order sheet). Data regarding use of care plan, length of stay (LOS), and rates of postoperative complications and readmission were recorded. One hundred eleven patients were included in the study; however, complete use of the ERP after its introduction occurred in a total of 50 patients for a compliance rate of 60 per cent (95% confidence interval [CI], 49 to 70). Late implementation of ERP diet, analgesics, and activity were the most common process errors. Full application of the ERP reduced mean LOS by 3 days (P=0.002), and there was a trend toward decreased postoperative morbidity without an increase in readmission rate (P=0.61). Full implementation of an ERP for colorectal surgery faces many challenges in a resource-limited county institution; however, when fully applied, the ERP safely reduced overall LOS, which is important in cost containment.

Combining features from ERP components in single-trial EEG for discriminating four-category visual objects.

PubMed

Wang, Changming; Xiong, Shi; Hu, Xiaoping; Yao, Li; Zhang, Jiacai

2012-10-01

Categorization of images containing visual objects can be successfully recognized using single-trial electroencephalograph (EEG) measured when subjects view images. Previous studies have shown that task-related information contained in event-related potential (ERP) components could discriminate two or three categories of object images. In this study, we investigated whether four categories of objects (human faces, buildings, cats and cars) could be mutually discriminated using single-trial EEG data. Here, the EEG waveforms acquired while subjects were viewing four categories of object images were segmented into several ERP components (P1, N1, P2a and P2b), and then Fisher linear discriminant analysis (Fisher-LDA) was used to classify EEG features extracted from ERP components. Firstly, we compared the classification results using features from single ERP components, and identified that the N1 component achieved the highest classification accuracies. Secondly, we discriminated four categories of objects using combining features from multiple ERP components, and showed that combination of ERP components improved four-category classification accuracies by utilizing the complementarity of discriminative information in ERP components. These findings confirmed that four categories of object images could be discriminated with single-trial EEG and could direct us to select effective EEG features for classifying visual objects.

Dimension reduction: additional benefit of an optimal filter for independent component analysis to extract event-related potentials.

PubMed

Cong, Fengyu; Leppänen, Paavo H T; Astikainen, Piia; Hämäläinen, Jarmo; Hietanen, Jari K; Ristaniemi, Tapani

2011-09-30

The present study addresses benefits of a linear optimal filter (OF) for independent component analysis (ICA) in extracting brain event-related potentials (ERPs). A filter such as the digital filter is usually considered as a denoising tool. Actually, in filtering ERP recordings by an OF, the ERP' topography should not be changed by the filter, and the output should also be able to be modeled by the linear transformation. Moreover, an OF designed for a specific ERP source or component may remove noise, as well as reduce the overlap of sources and even reject some non-targeted sources in the ERP recordings. The OF can thus accomplish both the denoising and dimension reduction (reducing the number of sources) simultaneously. We demonstrated these effects using two datasets, one containing visual and the other auditory ERPs. The results showed that the method including OF and ICA extracted much more reliable components than the sole ICA without OF did, and that OF removed some non-targeted sources and made the underdetermined model of EEG recordings approach to the determined one. Thus, we suggest designing an OF based on the properties of an ERP to filter recordings before using ICA decomposition to extract the targeted ERP component. Copyright © 2011 Elsevier B.V. All rights reserved.

A graphical user interface for infant ERP analysis.

PubMed

Kaatiala, Jussi; Yrttiaho, Santeri; Forssman, Linda; Perdue, Katherine; Leppänen, Jukka

2014-09-01

Recording of event-related potentials (ERPs) is one of the best-suited technologies for examining brain function in human infants. Yet the existing software packages are not optimized for the unique requirements of analyzing artifact-prone ERP data from infants. We developed a new graphical user interface that enables an efficient implementation of a two-stage approach to the analysis of infant ERPs. In the first stage, video records of infant behavior are synchronized with ERPs at the level of individual trials to reject epochs with noncompliant behavior and other artifacts. In the second stage, the interface calls MATLAB and EEGLAB (Delorme & Makeig, Journal of Neuroscience Methods 134(1):9-21, 2004) functions for further preprocessing of the ERP signal itself (i.e., filtering, artifact removal, interpolation, and rereferencing). Finally, methods are included for data visualization and analysis by using bootstrapped group averages. Analyses of simulated and real EEG data demonstrated that the proposed approach can be effectively used to establish task compliance, remove various types of artifacts, and perform representative visualizations and statistical comparisons of ERPs. The interface is available for download from http://www.uta.fi/med/icl/methods/eeg.html in a format that is widely applicable to ERP studies with special populations and open for further editing by users.

Using ERPs to Investigate Valence Processing in the Affect Misattribution Procedure

PubMed Central

Von Gunten, Curtis D.; Bartholow, Bruce D.; Scherer, Laura D.

2016-01-01

The construct validity of the Affect Misattribution Procedure (AMP) has been challenged by theories proposing that the task does not actually measure affect misattribution. The current study tested the validity of the AMP as a measure of affect misattribution by examining three components of the event-related potential (ERP) known to be associated with the allocation of motivated attention. Results revealed that ERP amplitudes varied in response to affectively ambiguous targets as a function of the valence of preceding primes. Furthermore, differences in ERP responses to the targets were largely similar to differences in ERPs elicited by the primes. The existence of valence differentiation in both the prime-locked and the target-locked ERPs, along with the similarity in this differentiation, provides evidence that the affective content of the primes is psychologically registered, and that this content influences the processing of the subsequent, evaluatively ambiguous targets, both of which are required if the priming effects found in the AMP are the result of affect misattribution. However, the behavioral priming effect was uncorrelated with ERP amplitudes, leaving some question as to the locus of this effect in the information-processing system. Findings are discussed in light of the strengths and weaknesses of using ERPs to understand the priming effects in the AMP. PMID:27754548

Anodonta imbecillis copper sulfate reference toxicant test, Clinch River - Environmental Restoration Program (CR-ERP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

1997-06-01

Reference toxicant testing using juvenile freshwater mussels was conducted as part of the CR-ERP biomonitoring study of Clinch River sediments to assess the sensitivity of test organisms and the overall performance of the test. Tests were conducted using moderately hard synthetic water spiked with known concentrations of copper as copper sulfate. Toxicity testing of copper sulfate reference toxicant was conducted from May 12-21, 1993. The organisms used for testing were juvenile fresh-water mussels (Anodonta imbecillis). Results from this test showed an LC{sub 50} value of 1.12 mg Cu/L which is lower than the value of 2.02 mg Cu/L obtained inmore » a previous test. Too few tests have been conducted with copper as the toxicant to determine a normal range of values.« less

Brain Activity Associated with Logical Inferences in Geometry: Focusing on Students with Different Levels of Ability

ERIC Educational Resources Information Center

Waisman, Ilana; Leikin, Mark; Leikin, Roza

2016-01-01

Mathematical processing associated with solving short geometry problems requiring logical inference was examined among students who differ in their levels of general giftedness (G) and excellence in mathematics (EM) using ERP research methodology. Sixty-seven male adolescents formed four major research groups designed according to various…

Identification of Chemicals of Interest to the Department of Defense and U.S. Air Force Among the U.S. Environmental Protection Agency’s Integrated Risk Information System Chemicals that are Due for Reassessment of their Toxicity Values

DTIC Science & Technology

2010-03-16

Exceeded at ERP Soil and Groundwater Sites 86 A-2a. Identification of IRIS Chemicals of Interest on the ATSDR CERCLA Priority List of Hazardous...the Number (Bold Font) of Air Force ERP Samples in Which They Were Detected 317 A-4d. Air Force ERP Soil Samples: IRIS Chemicals of Interest...Ranked by the Number (Bold Font) of Air Force ERP Soil Samples in Which They Were Detected 333 A-4e. Air Force ERP Groundwater Samples: IRIS Chemicals of

Evaluation of the effectiveness of neurofeedback in the reduction of Posttraumatic stress disorder (PTSD) in a patient following high-voltage electric shock with the use of ERPs.

PubMed

Chrapusta, Anna; Pąchalska, Maria; Wilk-Frańczuk, Magdalena; Starczyńska, Małgorzata; Kropotov, Juri D

2015-01-01

The aim of our research was an evaluation of the effectiveness of neurofeedback in reducing the symptoms of Post-trauma stress disorder (PTSD), which had developed as a result of a high-voltage electric burn to the head. Quantitative EEG (QEEG) and Event related potentials (ERPs) were utilised in the evaluation. A 21-year-old patient, experienced 4(th) degree burns to his head as a result of a high-voltage electric burn. The patient was repeatedly operated on and despite the severity of the injuries was to recover. However the patient complained of flashbacks, difficulties with sleeping as well as an inability to continue work in his given profession. Specialist tests were to show the presence within him of PTSD. As a result of which the patient was provided with neurofeedback therapy. The effectiveness of this therapy in the reduction (eradication) of the symptoms of PTSD were evaluated through the utilisation of qantitative eeg (Qeeg) and event related potentials (ERPs). It was found that in the first examination that ERPs display the most significant deviations from the reference in the two components: (1) the one component is generated within the cingulate cortex. The pattern of its deviation from the norms is similar to that found in a group of OCD patients. In contrast to healthy subjects the component repeats itself twice; (2) the second component is generated in the medial prefrontal cortex. Its pattern (neuromarker) is similar to that found in PTSD patients. There is a delay in the late part of the component, which probably reflects the flashbacks. In the second examination, after neurofeedback training, the ERPs were similar to the norm. The patient returned to work. Chronic PTSD developed within the patient as a result of a high-voltage electric burn. The application of a method of therapy (neurofeedback) resulted in the withdrawal of the syndrome symptoms. ERPs in a GO/NOGO task can be used to plan neurofeedback and in the assessment of functional brain changes induced by neurotherapeutic programmes. Funds Collection: Private sources.

Ingroup categorization and response conflict: Interactive effects of target race, flanker compatibility, and infrequency on N2 amplitude.

PubMed

Dickter, Cheryl L; Bartholow, Bruce D

2010-05-01

Three largely independent lines of research have investigated experimental manipulations that influence the amplitude of the N2 component of the event-related brain potential (ERP), one linking heightened N2 amplitude to response conflict, another showing that N2 is sensitive to stimulus infrequency, and the third showing larger N2 amplitude during categorization of racial ingroup relative to racial outgroup targets. The purpose of this research was to investigate potential interactions between these three features on the amplitude of the N2. ERPs were recorded while participants completed a modified flanker task using pictures of ingroup and outgroup faces. Results showed a 3-way interaction, indicating that the N2 was largest for ingroup targets on high-conflict trials but only when such trials were relatively infrequent. Implications of these findings for theories of both conflict monitoring and person perception are discussed.

Neural correlates of the implicit association test: evidence for semantic and emotional processing.

PubMed

Williams, John K; Themanson, Jason R

2011-09-01

The implicit association test (IAT) has been widely used in social cognitive research over the past decade. Controversies have arisen over what cognitive processes are being tapped into using this task. While most models use behavioral (RT) results to support their claims, little research has examined neurocognitive correlates of these behavioral measures. The present study measured event-related brain potentials (ERPs) of participants while completing a gay-straight IAT in order to further understand the processes involved in a typical group bias IAT. Results indicated significantly smaller N400 amplitudes and significantly larger LPP amplitudes for compatible trials than for incompatible trials, suggesting that both the semantic and emotional congruence of stimuli paired together in an IAT trial contribute to the typical RT differences found, while no differences were present for earlier ERP components including the N2. These findings are discussed with respect to early and late processing in group bias IATs.

Applying Real Options for Evaluating Investments in ERP Systems

NASA Astrophysics Data System (ADS)

Nakagane, Jun; Sekozawa, Teruji

This paper intends to verify effectiveness of real options approach for evaluating investments in Enterprise Resource Planning systems (ERP) and proves how important it is to disclose shadow options potentially embedded in ERP investment. The net present value (NPV) method is principally adopted to evaluate the value of ERP. However, the NPV method assumes no uncertainties exist in the object. It doesn't satisfy the current business circumstances which are filled with dynamic issues. Since the 1990s the effectiveness of option pricing models for Information System (IS) investment to solve issues in the NPV method has been discussed in the IS literature. This paper presents 3 business cases to review the practical advantages of such techniques for IS investments, especially ERP investments. The first case is EDI development. We evaluate the project by a new approach with lighting one of shadow options, EDI implementation. In the second case we reveal an ERP investment has an “expanding option” in a case of eliminating redundancy. The third case describes an option to contract which is deliberately slotted in ERP development to prepare transferring a manufacturing facility.

Case study of open-source enterprise resource planning implementation in a small business

NASA Astrophysics Data System (ADS)

Olson, David L.; Staley, Jesse

2012-02-01

Enterprise resource planning (ERP) systems have been recognised as offering great benefit to some organisations, although they are expensive and problematic to implement. The cost and risk make well-developed proprietorial systems unaffordable to small businesses. Open-source software (OSS) has become a viable means of producing ERP system products. The question this paper addresses is the feasibility of OSS ERP systems for small businesses. A case is reported involving two efforts to implement freely distributed ERP software products in a small US make-to-order engineering firm. The case emphasises the potential of freely distributed ERP systems, as well as some of the hurdles involved in their implementation. The paper briefly reviews highlights of OSS ERP systems, with the primary focus on reporting the case experiences for efforts to implement ERPLite software and xTuple software. While both systems worked from a technical perspective, both failed due to economic factors. While these economic conditions led to imperfect results, the case demonstrates the feasibility of OSS ERP for small businesses. Both experiences are evaluated in terms of risk dimension.

The oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules

PubMed Central

Antoniou, Antony N.; Ford, Stuart; Alphey, Magnus; Osborne, Andrew; Elliott, Tim; Powis, Simon J.

2002-01-01

The oxidoreductase ERp57 is an integral component of the peptide loading complex of major histocompatibility complex (MHC) class I molecules, formed during their chaperone-assisted assembly in the endoplasmic reticulum. Misfolded MHC class I molecules or those denied suitable peptides are retrotranslocated and degraded in the cytosol. The presence of ERp57 during class I assembly suggests it may be involved in the reduction of intrachain disulfides prior to retrotranslocation. We have studied the ability of ERp57 to reduce MHC class I molecules in vitro. Recombinant ERp57 specifically reduced partially folded MHC class I molecules, whereas it had little or no effect on folded and peptide-loaded MHC class I molecules. Reductase activity was associated with cysteines at positions 56 and 405 of ERp57, the N-terminal residues of the active CXXC motifs. Our data suggest that the reductase activity of ERp57 may be involved during the unfolding of MHC class I molecules, leading to targeting for degradation. PMID:12032078

Issues and considerations for using the scalp surface Laplacian in EEG/ERP research: A tutorial review.

PubMed

Kayser, Jürgen; Tenke, Craig E

2015-09-01

Despite the recognition that the surface Laplacian may counteract adverse effects of volume conduction and recording reference for surface potential data, electrophysiology as a discipline has been reluctant to embrace this approach for data analysis. The reasons for such hesitation are manifold but often involve unfamiliarity with the nature of the underlying transformation, as well as intimidation by a perceived mathematical complexity, and concerns of signal loss, dense electrode array requirements, or susceptibility to noise. We revisit the pitfalls arising from volume conduction and the mandated arbitrary choice of EEG reference, describe the basic principle of the surface Laplacian transform in an intuitive fashion, and exemplify the differences between common reference schemes (nose, linked mastoids, average) and the surface Laplacian for frequently-measured EEG spectra (theta, alpha) and standard event-related potential (ERP) components, such as N1 or P3. We specifically review common reservations against the universal use of the surface Laplacian, which can be effectively addressed by employing spherical spline interpolations with an appropriate selection of the spline flexibility parameter and regularization constant. We argue from a pragmatic perspective that not only are these reservations unfounded but that the continued predominant use of surface potentials poses a considerable impediment on the progress of EEG and ERP research. Copyright © 2015 Elsevier B.V. All rights reserved.

Cognitive changes in conjunctive rule-based category learning: An ERP approach.

PubMed

Rabi, Rahel; Joanisse, Marc F; Zhu, Tianshu; Minda, John Paul

2018-06-25

When learning rule-based categories, sufficient cognitive resources are needed to test hypotheses, maintain the currently active rule in working memory, update rules after feedback, and to select a new rule if necessary. Prior research has demonstrated that conjunctive rules are more complex than unidimensional rules and place greater demands on executive functions like working memory. In our study, event-related potentials (ERPs) were recorded while participants performed a conjunctive rule-based category learning task with trial-by-trial feedback. In line with prior research, correct categorization responses resulted in a larger stimulus-locked late positive complex compared to incorrect responses, possibly indexing the updating of rule information in memory. Incorrect trials elicited a pronounced feedback-locked P300 elicited which suggested a disconnect between perception, and the rule-based strategy. We also examined the differential processing of stimuli that were able to be correctly classified by the suboptimal single-dimensional rule ("easy" stimuli) versus those that could only be correctly classified by the optimal, conjunctive rule ("difficult" stimuli). Among strong learners, a larger, late positive slow wave emerged for difficult compared with easy stimuli, suggesting differential processing of category items even though strong learners performed well on the conjunctive category set. Overall, the findings suggest that ERP combined with computational modelling can be used to better understand the cognitive processes involved in rule-based category learning.

47 CFR 95.855 - Transmitter effective radiated power limitation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transmitter effective radiated power limitation. The effective radiated power (ERP) of each CTS and RTU shall... with an ERP exceeding 20 watts. No mobile RTU may transmit with an ERP exceeding 4 watts. [64 FR 59663...

47 CFR 95.855 - Transmitter effective radiated power limitation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transmitter effective radiated power limitation. The effective radiated power (ERP) of each CTS and RTU shall... with an ERP exceeding 20 watts. No mobile RTU may transmit with an ERP exceeding 4 watts. [64 FR 59663...

Predator Force Structure Changes at Indian Springs Air Force Auxiliary Field, Nevada Environmental Assessment

DTIC Science & Technology

2003-07-01

Office Agency for Nuclear Projects Energy Agriculture Business & Industry Minerals Economic Development Tourism Fire Marshal Human Resources...Agriculture Business & Industry Minerals Economic Development Tourism Fire Marshal Human Resources A in Services Indian Commission Colorado...Data EIAP Environmental Impact Analysis Process EMCS Central Energy Management System ERP Environmental Restoration Program ESA Endangered

ERP implementation in rural health care.

PubMed

Trimmer, Kenneth J; Pumphrey, Lela D; Wiggins, Carla

2002-01-01

Enterprise resource planning (ERP) systems provide organizations with the opportunity to integrate individual, functionally-oriented information systems. Although much of the focus in the popular press has been placed on ERP systems in large for-profit organizations, small hospitals and clinics are candidates for ERP systems. Focusing information systems on critical success factors (CSFs) allows the organization to address a limited number of areas associated with performance. This limited number of factors can provide management with an insight into dimensions of information that must be addressed by a system. Focuses on CSFs for small health-care organizations. In addition, also considers factors critical to the implementation of health-care information systems. Presents two cases. The results indicate support for the continuing use of CSFs to help focus on the benefits of ERPs. Focusing on groups of tangible and intangible benefits can also assist the rural health-care organization in the use of ERPs.

ERP-based detection of brain pathology in rat models for preclinical Alzheimer's disease

NASA Astrophysics Data System (ADS)

Nouriziabari, Seyed Berdia

Early pathological features of Alzheimer's disease (AD) include the accumulation of hyperphosphorylated tau protein (HP-tau) in the entorhinal cortex and progressive loss of basal forebrain (BF) cholinergic neurons. These pathologies are known to remain asymptomatic for many years before AD is clinically diagnosed; however, they may induce aberrant brain processing which can be captured as an abnormality in event-related potentials (ERPs). Here, we examined cortical ERPs while a differential associative learning paradigm was applied to adult male rats with entorhinal HP-tau, pharmacological blockade of muscarinic acetylcholine receptors, or both conditions. Despite no impairment in differential associative and reversal learning, each pathological feature induced distinct abnormality in cortical ERPs to an extent that was sufficient for machine classifiers to accurately detect a specific type of pathology based on these ERP features. These results highlight a potential use of ERPs during differential associative learning as a biomarker for asymptomatic AD pathology.

Hyperfocusing of attention on goal-related information in schizophrenia: Evidence from electrophysiology

PubMed Central

Sawaki, Risa; Kreither, Johanna; Leonard, Carly J.; Kaiser, Samuel T.; Hahn, Britta; Gold, James M.; Luck, Steven J.

2016-01-01

Schizophrenia clearly involves impairments of attention, but the precise nature of these impairments has been difficult to determine. One possibility is that the deficit in attention is a secondary consequence of a deficit in goal maintenance. However, recent research suggests that people with schizophrenia (PSZ) actually focus attention more strongly on objects containing goal-relevant features. To test these competing hypotheses, we recorded event-related potentials (ERPs) from PSZ (N = 20) and healthy control subjects (HCS, N = 20) while they looked for a particular target color at fixation and tried to ignore lateral distractors that sometimes matched the target color (target-color distractors). Goal maintenance was made trivially easy by the continual presentation of a goal reminder. We found that HCS were able to successfully suppress target-color distractors (leading to a PD ERP component), whereas PSZ focused attention on these items (leading to an N2pc ERP component). This suggests that, when maintaining a task set, PSZ engage in aberrant focusing of attention, or hyperfocusing, onto goal-relevant features. PMID:27709980

Low-Arousal Speech Noise Improves Performance in N-Back Task: An ERP Study

PubMed Central

Zhang, Dandan; Jin, Yi; Luo, Yuejia

2013-01-01

The relationship between noise and human performance is a crucial topic in ergonomic research. However, the brain dynamics of the emotional arousal effects of background noises are still unclear. The current study employed meaningless speech noises in the n-back working memory task to explore the changes of event-related potentials (ERPs) elicited by the noises with low arousal level vs. high arousal level. We found that the memory performance in low arousal condition were improved compared with the silent and the high arousal conditions; participants responded more quickly and had larger P2 and P3 amplitudes in low arousal condition while the performance and ERP components showed no significant difference between high arousal and silent conditions. These findings suggested that the emotional arousal dimension of background noises had a significant influence on human working memory performance, and that this effect was independent of the acoustic characteristics of noises (e.g., intensity) and the meaning of speech materials. The current findings improve our understanding of background noise effects on human performance and lay the ground for the investigation of patients with attention deficits. PMID:24204607

A periodic spatio-spectral filter for event-related potentials.

PubMed

Ghaderi, Foad; Kim, Su Kyoung; Kirchner, Elsa Andrea

2016-12-01

With respect to single trial detection of event-related potentials (ERPs), spatial and spectral filters are two of the most commonly used pre-processing techniques for signal enhancement. Spatial filters reduce the dimensionality of the data while suppressing the noise contribution and spectral filters attenuate frequency components that most likely belong to noise subspace. However, the frequency spectrum of ERPs overlap with that of the ongoing electroencephalogram (EEG) and different types of artifacts. Therefore, proper selection of the spectral filter cutoffs is not a trivial task. In this research work, we developed a supervised method to estimate the spatial and finite impulse response (FIR) spectral filters, simultaneously. We evaluated the performance of the method on offline single trial classification of ERPs in datasets recorded during an oddball paradigm. The proposed spatio-spectral filter improved the overall single-trial classification performance by almost 9% on average compared with the case that no spatial filters were used. We also analyzed the effects of different spectral filter lengths and the number of retained channels after spatial filtering. Copyright © 2016. Published by Elsevier Ltd.

Effects of a psychophysiological system for adaptive automation on performance, workload, and the event-related potential P300 component

NASA Technical Reports Server (NTRS)

Prinzel, Lawrence J 3rd; Freeman, Frederick G.; Scerbo, Mark W.; Mikulka, Peter J.; Pope, Alan T.

2003-01-01

The present study examined the effects of an electroencephalographic- (EEG-) based system for adaptive automation on tracking performance and workload. In addition, event-related potentials (ERPs) to a secondary task were derived to determine whether they would provide an additional degree of workload specificity. Participants were run in an adaptive automation condition, in which the system switched between manual and automatic task modes based on the value of each individual's own EEG engagement index; a yoked control condition; or another control group, in which task mode switches followed a random pattern. Adaptive automation improved performance and resulted in lower levels of workload. Further, the P300 component of the ERP paralleled the sensitivity to task demands of the performance and subjective measures across conditions. These results indicate that it is possible to improve performance with a psychophysiological adaptive automation system and that ERPs may provide an alternative means for distinguishing among levels of cognitive task demand in such systems. Actual or potential applications of this research include improved methods for assessing operator workload and performance.

Hyperfocusing of attention on goal-related information in schizophrenia: Evidence from electrophysiology.

PubMed

Sawaki, Risa; Kreither, Johanna; Leonard, Carly J; Kaiser, Samuel T; Hahn, Britta; Gold, James M; Luck, Steven J

2017-01-01

Schizophrenia clearly involves impairments of attention, but the precise nature of these impairments has been difficult to determine. One possibility is that the deficit in attention is a secondary consequence of a deficit in goal maintenance. However, recent research suggests that people with schizophrenia (PSZ) actually focus attention more strongly on objects containing goal-relevant features. To test these competing hypotheses, we recorded event-related potentials (ERPs) from PSZ (N = 20) and healthy control subjects (HCS; N = 20) while they looked for a particular target color at fixation and tried to ignore lateral distractors that sometimes matched the target color (target-color distractors). Goal maintenance was made trivially easy by the continual presentation of a goal reminder. We found that HCS were able to successfully suppress target-color distractors (leading to a distractor positivity ERP component), whereas PSZ focused attention on these items (leading to an N2-posterior-contralateral ERP component). This suggests that, when maintaining a task set, PSZ engage in aberrant focusing of attention, or hyperfocusing, on goal-relevant features. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Information system and website design to support theautomotive manufacture ERP system

NASA Astrophysics Data System (ADS)

Amran, T. G.; Azmi, N.; Surjawati, A. A.

2017-12-01

This research is to create an on-time production system design with Heijunka model so that the product diversity for all models could meet time and capacity requirements, own production flexibility, high quality, meet the customers’ demands, realistic in production as well as creating a web-based local components’ order information system that supports the Enterprise Resource Planning (ERP) system. The Heijunka model for equalization with heuristic and stochastic model has been implemented for productions up to 3000 units by implementing Suzuki International Manufacturing. The inefficiency in the local order information system demanded the need for a new information system design that is integrated in ERP. Kaizen needs to be done is the Supplier Network that all vendors can download and utilize those data to deliver the components to the company and for vendors’ internal uses as well. The model design is presumed effective where the model is able to be utilized as a solution so that the production can run according to the schedule and presumed efficient were the model is able to show the reduction of loss time and stock.

Description-based reappraisal regulate the emotion induced by erotic and neutral images in a Chinese population.

PubMed

Peng, Jiaxin; Qu, Chen; Gu, Ruolei; Luo, Yue-Jia

2012-01-01

Previous emotion-regulation research has shown that the late positive potential (LPP) is sensitive to the down-regulation of emotion; however, whether LPP is also sensitive to the up-regulation of emotion remains unclear. The present study examined the description-based reappraisal effects on the up-regulation of positive emotions induced by erotic and neutral images in a Chinese population. Self-reported ratings and event-related potential (ERP) were recorded when subjects viewed pleasant and neutral images, which were shown after either a neutral or positive description. Self-reported results showed that images following positive descriptions were rated as more pleasant compared to images following neutral descriptions. ERP results revealed that the P2, P3, and slow wave (SW) components were larger for erotic pictures than for neutral pictures, while the positive description condition yielded attenuated erotic image-induced P2, P3 and SW and increased SW induced by neutral images. The results demonstrated that description-based reappraisal, as a method of reappraisal, significantly modulates the emotional experience and ERP responses to erotic and neutral images.

Prenatal Cocaine Exposure Impacts Language and Reading Into Late Adolescence: Behavioral and ERP Evidence.

PubMed

Landi, Nicole; Avery, Trey; Crowley, Michael J; Wu, Jia; Mayes, Linda

2017-01-01

Extant research documents impaired language among children with prenatal cocaine exposure (PCE) relative to nondrug exposed (NDE) children, suggesting that cocaine alters development of neurobiological systems that support language. The current study examines behavioral and neural (electrophysiological) indices of language function in older adolescents. Specifically, we compare performance of PCE (N = 59) and NDE (N = 51) adolescents on a battery of cognitive and linguistic assessments that tap word reading, reading comprehension, semantic and grammatical processing, and IQ. In addition, we examine event related potential (ERP) responses in in a subset of these children across three experimental tasks that examine word level phonological processing (rhyme priming), word level semantic processing (semantic priming), and sentence level semantic processing (semantic anomaly). Findings reveal deficits across a number of reading and language assessments, after controlling for socioeconomic status and exposure to other substances. Additionally, ERP data reveal atypical orthography to phonology mapping (reduced N1/P2 response) and atypical rhyme and semantic processing (N400 response). These findings suggest that PCE continues to impact language and reading skills into the late teenage years.

Balloons and bavoons versus spikes and shikes: ERPs reveal shared neural processes for shape-sound-meaning congruence in words, and shape-sound congruence in pseudowords.

PubMed

Sučević, Jelena; Savić, Andrej M; Popović, Mirjana B; Styles, Suzy J; Ković, Vanja

2015-01-01

There is something about the sound of a pseudoword like takete that goes better with a spiky, than a curvy shape (Köhler, 1929:1947). Yet despite decades of research into sound symbolism, the role of this effect on real words in the lexicons of natural languages remains controversial. We report one behavioural and one ERP study investigating whether sound symbolism is active during normal language processing for real words in a speaker's native language, in the same way as for novel word forms. The results indicate that sound-symbolic congruence has a number of influences on natural language processing: Written forms presented in a congruent visual context generate more errors during lexical access, as well as a chain of differences in the ERP. These effects have a very early onset (40-80 ms, 100-160 ms, 280-320 ms) and are later overshadowed by familiar types of semantic processing, indicating that sound symbolism represents an early sensory-co-activation effect. Copyright © 2015 Elsevier Inc. All rights reserved.

Emotion and attention: event-related brain potential studies.

PubMed

Schupp, Harald T; Flaisch, Tobias; Stockburger, Jessica; Junghöfer, Markus

2006-01-01

Emotional pictures guide selective visual attention. A series of event-related brain potential (ERP) studies is reviewed demonstrating the consistent and robust modulation of specific ERP components by emotional images. Specifically, pictures depicting natural pleasant and unpleasant scenes are associated with an increased early posterior negativity, late positive potential, and sustained positive slow wave compared with neutral contents. These modulations are considered to index different stages of stimulus processing including perceptual encoding, stimulus representation in working memory, and elaborate stimulus evaluation. Furthermore, the review includes a discussion of studies exploring the interaction of motivated attention with passive and active forms of attentional control. Recent research is reviewed exploring the selective processing of emotional cues as a function of stimulus novelty, emotional prime pictures, learned stimulus significance, and in the context of explicit attention tasks. It is concluded that ERP measures are useful to assess the emotion-attention interface at the level of distinct processing stages. Results are discussed within the context of two-stage models of stimulus perception brought out by studies of attention, orienting, and learning.

The lasting memory enhancements of retrospective attention

PubMed Central

Reaves, Sarah; Strunk, Jonathan; Phillips, Shekinah; Verhaeghen, Paul; Duarte, Audrey

2016-01-01

Behavioral research has shown that spatial cues that orient attention toward task relevant items being maintained in visual short-term memory (VSTM) enhance item memory accuracy. However, it is unknown if these retrospective attentional cues (“retro-cues”) enhance memory beyond typical short-term memory delays. It is also unknown whether retro-cues affect the spatial information associated with VSTM representations. Emerging evidence suggests that processes that affect short-term memory maintenance may also affect long-term memory (LTM) but little work has investigated the role of attention in LTM. In the current event-related potential (ERP) study, we investigated the duration of retrospective attention effects and the impact of retrospective attention manipulations on VSTM representations. Results revealed that retro-cueing improved both VSTM and LTM memory accuracy and that posterior maximal ERPs observed during VSTM maintenance predicted subsequent LTM performance. N2pc ERPs associated with attentional selection were attenuated by retro-cueing suggesting that retrospective attention may disrupt maintenance of spatial configural information in VSTM. Collectively, these findings suggest that retrospective attention can alter the structure of memory representations, which impacts memory performance beyond short-term memory delays. PMID:27038756

Description-based reappraisal regulate the emotion induced by erotic and neutral images in a Chinese population

PubMed Central

Peng, Jiaxin; Qu, Chen; Gu, Ruolei; Luo, Yue-Jia

2013-01-01

Previous emotion-regulation research has shown that the late positive potential (LPP) is sensitive to the down-regulation of emotion; however, whether LPP is also sensitive to the up-regulation of emotion remains unclear. The present study examined the description-based reappraisal effects on the up-regulation of positive emotions induced by erotic and neutral images in a Chinese population. Self-reported ratings and event-related potential (ERP) were recorded when subjects viewed pleasant and neutral images, which were shown after either a neutral or positive description. Self-reported results showed that images following positive descriptions were rated as more pleasant compared to images following neutral descriptions. ERP results revealed that the P2, P3, and slow wave (SW) components were larger for erotic pictures than for neutral pictures, while the positive description condition yielded attenuated erotic image-induced P2, P3 and SW and increased SW induced by neutral images. The results demonstrated that description-based reappraisal, as a method of reappraisal, significantly modulates the emotional experience and ERP responses to erotic and neutral images. PMID:23335894

The Neural Response to Maternal Stimuli: An ERP Study

PubMed Central

Wu, Lili; Gu, Ruolei; Cai, Huajian; Luo, Yu L. L.; Zhang, Jianxin

2014-01-01

Mothers are important to all humans. Research has established that maternal information affects individuals' cognition, emotion, and behavior. We measured event-related potentials (ERPs) to examine attentional and evaluative processing of maternal stimuli while participants completed a Go/No-go Association Task that paired mother or others words with good or bad evaluative words. Behavioral data showed that participants responded faster to mother words paired with good than the mother words paired with bad but showed no difference in response to these others across conditions, reflecting a positive evaluation of mother. ERPs showed larger P200 and N200 in response to mother than in response to others, suggesting that mother attracted more attention than others. In the subsequent time window, mother in the mother + bad condition elicited a later and larger late positive potential (LPP) than it did in the mother + good condition, but this was not true for others, also suggesting a positive evaluation of mother. These results suggest that people differentiate mother from others during initial attentional stage, and evaluative mother positively during later stage. PMID:25375157

The Interaction of Arousal and Valence in Affective Priming: Behavioral and Electrophysiological Evidence

PubMed Central

Zhang, Qin; Kong, Lingyue; Jiang, Yang

2013-01-01

The affective priming paradigm has been studied extensively and applied in many fields during the past two decades. Most research thus far has focused on the valence dimension. Whether emotional arousal influences affective priming remains poorly understood. The present study demonstrates how arousal impacts evaluation of affective words using reaction time and event-related potential (ERP) measures. Eighteen younger subjects evaluated pleasantness of target words after seeing affective pictures as primes. The participants’ responses were faster and/or more accurate for valence-congruent trials than for incongruent trials, particularly with high-arousal stimuli. An ERP affective priming effect (N400) also occurred mainly in high-arousing stimulus pairs. In addition, whereas valence congruency influenced both the N400 and the LPP, arousal congruency influenced only the LPP, suggesting that arousal congruency mainly modulates post-semantic processes, but valence congruency effects begin with semantic processes. Overall, our current findings indicate that the arousal level of visual images impacts both behavioral and ERP effects of affective priming. Section Cognitive and Behavioral Neuroscience PMID:22820299

Neurocognitive rehabilitation for addiction medicine: From neurophysiological markers to cognitive rehabilitation and relapse prevention.

PubMed

Campanella, Salvatore

2016-01-01

Currently, relapse prevention remains the main challenge in addiction medicine, indicating that the established treatment methods combining psychotherapy with neuropharmacological interventions are not entirely effective. Therefore, there is a push to develop alternatives to psychotherapy- and medication-based approaches to addiction treatment. Two major cognitive factors have been identified that trigger relapse in addicted patients: attentional biases directed toward drug-related cues, which increase the urge to consume, and impaired response inhibition toward these cues, which makes it more difficult for addicted people to resist temptation. Recent studies on newly detoxified alcoholic patients have shown that by using the appropriate tasks to index these cognitive functions with event-related potentials (ERPs), it is possible to discriminate between future relapsers and nonrelapsers. These preliminary data suggest that the ERP technique has great clinical potential for preventing relapse in alcohol-dependent patients, as well as for addictive states in general. Indeed, ERPs may help to identify patients highly vulnerable to relapse and allow the development of individually adapted cognitive rehabilitation programs. The implementation of this combined approach requires an intense collaboration between psychiatry departments, clinical neurophysiology laboratories, and neuropsychological rehabilitation centers. The potential pitfalls and limitations of this approach are also discussed. © 2016 Elsevier B.V. All rights reserved.

Family-based exposure and response prevention therapy for preschool-aged children with obsessive-compulsive disorder: a pilot randomized controlled trial.

PubMed

Lewin, Adam B; Park, Jennifer M; Jones, Anna M; Crawford, Erika A; De Nadai, Alessandro S; Menzel, Jessie; Arnold, Elysse B; Murphy, Tanya K; Storch, Eric A

2014-05-01

To examine the feasibility, acceptability and preliminary efficacy of family-based exposure/response prevention therapy (E/RP) versus treatment as usual (TAU) in a cohort of very young children with early onset obsessive-compulsive disorder (OCD). Thirty-one children ages 3-8 years (M = 5.8 years) with a primary diagnosis of OCD were randomized to E/RP or TAU. The E/RP condition received 12 sessions of family-based E/RP twice weekly over 6 weeks. Families were assessed at baseline, post-treatment, 1-month and 3-month follow up. The Children's Yale Brown Obsessive Compulsive Scale and Clinical Global Impression served as primary outcome measures. A large group effect emerged in favor of the E/RP group (d = 1.69). Sixty-five percent of the E/RP group was considered treatment responders as compared to 7% in the TAU group. Symptom remission was achieved in 35.2% of the E/RP group and 0% of the TAU group. There was no attrition and satisfaction was high; gains were maintained at 3 months. Even amongst children as young as 3 years, developmentally tailored E/RP is efficacious and well-tolerated in reducing OCD symptoms. Key adaptations for younger children include extensive parent involvement, targeting family accommodation, and frequent meetings while delivering a full course of E/RP. NCT01447966 http://clinicaltrials.gov/ct2/show/NCT01447966?term=ocd+and+st+petersburg&rank=1. Copyright © 2014 Elsevier Ltd. All rights reserved.

How to validate similarity in linear transform models of event-related potentials between experimental conditions?

PubMed

Cong, Fengyu; Lin, Qiu-Hua; Astikainen, Piia; Ristaniemi, Tapani

2014-10-30

It is well-known that data of event-related potentials (ERPs) conform to the linear transform model (LTM). For group-level ERP data processing using principal/independent component analysis (PCA/ICA), ERP data of different experimental conditions and different participants are often concatenated. It is theoretically assumed that different experimental conditions and different participants possess the same LTM. However, how to validate the assumption has been seldom reported in terms of signal processing methods. When ICA decomposition is globally optimized for ERP data of one stimulus, we gain the ratio between two coefficients mapping a source in brain to two points along the scalp. Based on such a ratio, we defined a relative mapping coefficient (RMC). If RMCs between two conditions for an ERP are not significantly different in practice, mapping coefficients of this ERP between the two conditions are statistically identical. We examined whether the same LTM of ERP data could be applied for two different stimulus types of fearful and happy facial expressions. They were used in an ignore oddball paradigm in adult human participants. We found no significant difference in LTMs (based on ICASSO) of N170 responses to the fearful and the happy faces in terms of RMCs of N170. We found no methods for straightforward comparison. The proposed RMC in light of ICA decomposition is an effective approach for validating the similarity of LTMs of ERPs between experimental conditions. This is very fundamental to apply group-level PCA/ICA to process ERP data. Copyright © 2014 Elsevier B.V. All rights reserved.

Using Event-related Potentials to Inform the Neurocognitive Processes Underlying Knowledge Extension through Memory Integration.

PubMed

Varga, Nicole L; Bauer, Patricia J

2017-11-01

To build a general knowledge base, it is imperative that individuals acquire, integrate, and further extend knowledge across experiences. For instance, in one episode an individual may learn that George Washington was the first president. In a separate episode they may then learn that Washington was the commander of the Continental Army. Integration of the information in memory may then support self-derivation of the new knowledge that the leader of the Continental Army was also the first president. Despite a considerable amount of fMRI research aimed at further elucidating the neuroanatomical regions supporting this ability, a consensus has yet to be reached with regards to the precise neurocognitive processes involved. In the present research, we capitalized on the high temporal resolution of event-related potentials (ERPs) to inform the time course of processes elicited during successful integration and further extension of new factual knowledge. Adults read novel, related stem facts and were tested for self-derivation of novel integration facts while ERPs were recorded. Consistent with current theoretical models, memory integration was first triggered by novelty detection within 400 msec of experience of a second, related stem fact. Two additional temporally staged encoding processes were then observed interpreted to reflect (1) explicit meaning comprehension and (2) representation of the integrated relation in memory. During the test for self-derivation, a single ERP was elicited, which presumably reflected retrieval and/or recombination of previously integrated knowledge. Together, the present research provides important insight into the time course of neurocognitive processing associated with the formation of a knowledge base.

Sustained dysfunctional information processing in patients with Internet gaming disorder: 6-month follow-up ERP study.

PubMed

Park, Minkyung; Kim, Yeon Jin; Kim, Dai Jin; Choi, Jung-Seok

2017-09-01

Internet gaming disorder (IGD), defined as an inability to control Internet-based game play, leads to serious impairment in psychological and social functioning, but few studies have identified the neurophysiological characteristics of patients with IGD. The aim of this study was to determine neurophysiological markers of P300 components associated with changes in symptoms after outpatient management with pharmacotherapy in patients with IGD. The present prospective longitudinal study included 18 patients with IGD and 29 healthy controls. The patients with IGD completed a 6-month outpatient management program including selective serotonin reuptake inhibitor-based pharmacotherapy. Event-related potentials (ERPs) were acquired during the auditory oddball task. ERPs of the patients with IGD were recorded before and after treatment. Between-group differences and the pre-to-post treatment differences in P300 components were investigated using repeated-measures analysis of variance. The primary treatment outcome was a change in score on Young Internet Addiction Test between before and after treatment. At baseline assessments, the IGD group showed significantly reduced P300 amplitudes and delayed latencies at the midline centro-parietal site compared with those in the healthy controls. No significant changes in the P300 indices were observed between pre and post-treatment in the patients with IGD after 6 months of treatment, even though the patients with IGD exhibited significant improvements in their IGD symptoms. Furthermore, no significant difference in ERPs was observed between responders and nonresponders to a 6-month treatment in patients with IGD. These results suggest that reduced P300 amplitudes and delayed latencies are candidate endophenotypes in the pathophysiology of IGD.

EPA Administrative Order on Consent (AOC) with ERP Compliant Coke, LLC

EPA Pesticide Factsheets

This Administrative Order on Consent with ERP Compliant Coke was effective August 2016. The Walter Coke facility located in North Birmingham was purchased by ERP Compliant Coke, LLC in February 2016 out of bankruptcy proceedings.

Organization Readiness and ERP Implementation in Albaha University

NASA Astrophysics Data System (ADS)

Alaqeel, K.; Shakkah, M. S.; Rahmat, R. F.; Alfageeh, A.; Budiarto, R.

2017-04-01

This work studies the correlation between the organizational readiness in Albaha University and the respective Critical Success Factors with regards to the Enterprise Resource Planning (ERP) implementation. The study also considers some suggestions to improve the ABU’s ERP systems and roadmap towards the self -development strategy and to reduce vendor-dependency. A survey regarding ERP to the end-users, experts and developers in Albaha University was conducted. The analysis of the results in this work confirmed with the results of an existing work. The four significance success factors: Project Management, Business Process Re-engineering, System Integration, and Training and Education are recommended to be adopted to assure the smooth adoption of ERP at Albaha University.

Evaluation of effectiveness of information systems implementation in organization (by example of ERP-systems)

NASA Astrophysics Data System (ADS)

Demyanova, O. V.; Andreeva, E. V.; Sibgatullina, D. R.; Kireeva-Karimova, A. M.; Gafurova, A. Y.; Zakirova, Ch S.

2018-05-01

ERP in a modern enterprise information system allowed optimizing internal business processes, reducing production costs and increasing the attractiveness of enterprises for investors. It is an important component of success in the competition and an important condition for attracting investments in the key sector of the state. A vivid example of these systems are enterprise information systems using the methodology of ERP (Enterprise Resource Planning - enterprise resource planning). ERP is an integrated set of methods, processes, technologies and tools. It is based on: supply chain management; advanced planning and scheduling; sales automation; tool responsible for configuring; final resource planning; intelligence business; OLAP technology; block e- Commerce; management of product data. The main purpose of ERP systems is the automation of interrelated processes of planning, accounting and management in key areas of the company. ERP systems are automated systems that effectively address complex problems, including optimal allocation of business resources, ensuring quick and efficient delivery of goods and services to the consumer. Knowledge embedded in ERP systems provided enterprise-wide automation to introduce the activities of all functional departments of the company as a single complex system. At the level of quality estimates, most managers understand that the implementations of ERP systems is a necessary and useful procedure. Assessment of the effectiveness of the information systems implementation is relevant.

Internal versus external features in triggering the brain waveforms for conjunction and feature faces in recognition.

PubMed

Nie, Aiqing; Jiang, Jingguo; Fu, Qiao

2014-08-20

Previous research has found that conjunction faces (whose internal features, e.g. eyes, nose, and mouth, and external features, e.g. hairstyle and ears, are from separate studied faces) and feature faces (partial features of these are studied) can produce higher false alarms than both old and new faces (i.e. those that are exactly the same as the studied faces and those that have not been previously presented) in recognition. The event-related potentials (ERPs) that relate to conjunction and feature faces at recognition, however, have not been described as yet; in addition, the contributions of different facial features toward ERPs have not been differentiated. To address these issues, the present study compared the ERPs elicited by old faces, conjunction faces (the internal and the external features were from two studied faces), old internal feature faces (whose internal features were studied), and old external feature faces (whose external features were studied) with those of new faces separately. The results showed that old faces not only elicited an early familiarity-related FN400, but a more anterior distributed late old/new effect that reflected recollection. Conjunction faces evoked similar late brain waveforms as old internal feature faces, but not to old external feature faces. These results suggest that, at recognition, old faces hold higher familiarity than compound faces in the profiles of ERPs and internal facial features are more crucial than external ones in triggering the brain waveforms that are characterized as reflecting the result of familiarity.

The concurrent use of three implicit measures (eye movements, pupillometry, and event-related potentials) to assess receptive vocabulary knowledge in normal adults.

PubMed

Ledoux, Kerry; Coderre, Emily; Bosley, Laura; Buz, Esteban; Gangopadhyay, Ishanti; Gordon, Barry

2016-03-01

Recent years have seen the advent and proliferation of the use of implicit techniques to study learning and cognition. One such application is the use of event-related potentials (ERPs) to assess receptive vocabulary knowledge. Other implicit assessment techniques that may be well-suited to other testing situations or to use with varied participant groups have not been used as widely to study receptive vocabulary knowledge. We sought to develop additional implicit techniques to study receptive vocabulary knowledge that could augment the knowledge gained from the use of the ERP technique. Specifically, we used a simple forced-choice paradigm to assess receptive vocabulary knowledge in normal adult participants using eye movement monitoring (EM) and pupillometry. In the same group of participants, we also used an N400 semantic incongruity ERP paradigm to assess their knowledge of two groups of words: those expected to be known to the participants (high-frequency, familiar words) and those expected to be unknown (low-frequency, unfamiliar words). All three measures showed reliable differences between the known and unknown words. EM and pupillometry thus may provide insight into receptive vocabulary knowledge similar to that from ERPs. The development of additional implicit assessment techniques may increase the feasibility of receptive vocabulary testing across a wider range of participant groups and testing situations, and may make the conduct of such testing more accessible to a wider range of researchers, clinicians, and educators.

Introducing an enhanced recovery programme to an established totally intracorporeal robot-assisted radical cystectomy service.

PubMed

Collins, Justin W; Adding, Christofer; Hosseini, Abolfazl; Nyberg, Tommy; Pini, Giovannalberto; Dey, Linda; Wiklund, Peter N

2016-01-01

The aim of this study was to assess the effect of introducing an enhanced recovery programme (ERP) to an established robot-assisted radical cystectomy (RARC) service. Data were prospectively collected on 221 consecutive patients undergoing totally intracorporeal RARC between December 2003 and May 2014. The ERP was specifically designed to support an evolving RARC service, where increasing proportions of patients requiring radical cystectomy underwent RARC. Patient demographics and outcomes before and after implementation of the ERP were compared. The primary endpoint was length of stay (LOS). Secondary outcomes included age, American Society of Anesthesiologists (ASA) score, preoperative staging, operative time, complications and readmissions. Differences in outcomes between patients before and after implementation of ERP were tested with the Jonckheere-Terpstra trend test and quantile regression with backward selection. Following implementation of the ERP, the demographics of the patients (n = 135) changed, with median age increasing from 66 to 70 years (p < 0.01), higher ASA grade (p < 0.001), higher preoperative stage cancer (pT ≥ 2, p < 0.05) and increased likelihood of undergoing an ileal conduit diversion (p < 0.001). Median LOS before ERP was 9 days [interquartile range (IQR) 8-13 days] and after ERP was 8 days (IQR 6-10 days) (p < 0.001). ASA grade and neoadjuvant chemotherapy also affected LOS (p < 0.05 and p < 0.01, respectively). There was no significant difference in 30 day complication rates, readmission rates or 90 day mortality, with 59% experiencing complications before ERP implementation and 57% after implementation. The majority of complications were low grade. Patient demographics changed as the RARC service evolved from selected patients to a general service. Despite worsening demographics, LOS decreased following ERP implementation. This evidence-based ERP safely standardized perioperative care, resulting in decreased LOS and decreased variability in LOS.

ERPS to Monitor Non-conscious Mentation

NASA Technical Reports Server (NTRS)

Donchin, E.

1984-01-01

Event Related Brain Potentials (or ERPs) are extracted from the EEG that can be recorded between a pair of electrodes placed on a person's scalp. The EEG is recorded as a continual fluctuation in voltage. It is the results of the integration of the potential fields generated by a multitude of neuronal ensembles that are active as the brain goes about its business. Within this ongoing signal it is possible to distinguish voltage fluctuations that are triggered in neural structures by the occurrence of specific events. This activity, evoked as it is by an external event, is known as the Evoked, or Event Related, Potential. The ERPs provide a unique opportunity to monitor non-conscious mentation. The inferences that can be based on ERP data are described and the limits of these inferences are emphasized. This, however, will not be an exhaustive review of the use of ERPs in Engineering Psychology. The application, its scope, and its limitations will be illustrated by means of one example. This example is preceded by a brief technical introduction to the methodology used in the study of ERPs. The manner in which ERPs are used to study cognition is described.

Auditory evoked potentials in patients with major depressive disorder measured by Emotiv system.

PubMed

Wang, Dongcui; Mo, Fongming; Zhang, Yangde; Yang, Chao; Liu, Jun; Chen, Zhencheng; Zhao, Jinfeng

2015-01-01

In a previous study (unpublished), Emotiv headset was validated for capturing event-related potentials (ERPs) from normal subjects. In the present follow-up study, the signal quality of Emotiv headset was tested by the accuracy rate of discriminating Major Depressive Disorder (MDD) patients from the normal subjects. ERPs of 22 MDD patients and 15 normal subjects were induced by an auditory oddball task and the amplitude of N1, N2 and P3 of ERP components were specifically analyzed. The features of ERPs were statistically investigated. It is found that Emotiv headset is capable of discriminating the abnormal N1, N2 and P3 components in MDD patients. Relief-F algorithm was applied to all features for feature selection. The selected features were then input to a linear discriminant analysis (LDA) classifier with leave-one-out cross-validation to characterize the ERP features of MDD. 127 possible combinations out of the selected 7 ERP features were classified using LDA. The best classification accuracy was achieved to be 89.66%. These results suggest that MDD patients are identifiable from normal subjects by ERPs measured by Emotiv headset.

Memory Distortion and Its Avoidance: An Event-Related Potentials Study on False Recognition and Correct Rejection

PubMed Central

Beato, Maria Soledad

2016-01-01

Memory researchers have long been captivated by the nature of memory distortions and have made efforts to identify the neural correlates of true and false memories. However, the underlying mechanisms of avoiding false memories by correctly rejecting related lures remains underexplored. In this study, we employed a variant of the Deese/Roediger-McDermott paradigm to explore neural signatures of committing and avoiding false memories. ERP were obtained for True recognition, False recognition, Correct rejection of new items, and, more importantly, Correct rejection of related lures. With these ERP data, early-frontal, left-parietal, and late right-frontal old/new effects (associated with familiarity, recollection, and monitoring processes, respectively) were analysed. Results indicated that there were similar patterns for True and False recognition in all three old/new effects analysed in our study. Also, False recognition and Correct rejection of related lures activities seemed to share common underlying familiarity-based processes. The ERP similarities between False recognition and Correct rejection of related lures disappeared when recollection processes were examined because only False recognition presented a parietal old/new effect. This finding supported the view that actual false recollections underlie false memories, providing evidence consistent with previous behavioural research and with most ERP and neuroimaging studies. Later, with the onset of monitoring processes, False recognition and Correct rejection of related lures waveforms presented, again, clearly dissociated patterns. Specifically, False recognition and True recognition showed more positive going patterns than Correct rejection of related lures signal and Correct rejection of new items signature. Since False recognition and Correct rejection of related lures triggered familiarity-recognition processes, our results suggest that deciding which items are studied is based more on recollection processes, which are later supported by monitoring processes. Results are discussed in terms of Activation-Monitoring Framework and Fuzzy Trace-Theory, the most prominent explanatory theories of false memory raised with the Deese/Roediger-McDermott paradigm. PMID:27711125

Memory Distortion and Its Avoidance: An Event-Related Potentials Study on False Recognition and Correct Rejection.

PubMed

Cadavid, Sara; Beato, Maria Soledad

2016-01-01

Memory researchers have long been captivated by the nature of memory distortions and have made efforts to identify the neural correlates of true and false memories. However, the underlying mechanisms of avoiding false memories by correctly rejecting related lures remains underexplored. In this study, we employed a variant of the Deese/Roediger-McDermott paradigm to explore neural signatures of committing and avoiding false memories. ERP were obtained for True recognition, False recognition, Correct rejection of new items, and, more importantly, Correct rejection of related lures. With these ERP data, early-frontal, left-parietal, and late right-frontal old/new effects (associated with familiarity, recollection, and monitoring processes, respectively) were analysed. Results indicated that there were similar patterns for True and False recognition in all three old/new effects analysed in our study. Also, False recognition and Correct rejection of related lures activities seemed to share common underlying familiarity-based processes. The ERP similarities between False recognition and Correct rejection of related lures disappeared when recollection processes were examined because only False recognition presented a parietal old/new effect. This finding supported the view that actual false recollections underlie false memories, providing evidence consistent with previous behavioural research and with most ERP and neuroimaging studies. Later, with the onset of monitoring processes, False recognition and Correct rejection of related lures waveforms presented, again, clearly dissociated patterns. Specifically, False recognition and True recognition showed more positive going patterns than Correct rejection of related lures signal and Correct rejection of new items signature. Since False recognition and Correct rejection of related lures triggered familiarity-recognition processes, our results suggest that deciding which items are studied is based more on recollection processes, which are later supported by monitoring processes. Results are discussed in terms of Activation-Monitoring Framework and Fuzzy Trace-Theory, the most prominent explanatory theories of false memory raised with the Deese/Roediger-McDermott paradigm.

Psychometric properties of neural responses to monetary and social rewards across development.

PubMed

Ethridge, Paige; Weinberg, Anna

2018-02-02

Reward-related event-related potentials (ERPs) are often used to index individual differences that signal the presence or predict the onset of psychopathology. However, relatively little research has explored the psychometric properties of reward-related ERPs. Without understanding their psychometric properties, the value of using ERPs as biomarkers for psychopathology is limited. The present study, therefore, sought to establish the internal consistency reliability and convergent validity of the reward positivity (RewP) and feedback negativity (FN) elicited by two types of incentives commonly used in individual differences research - monetary and social rewards. A large, developmentally-diverse sample completed a forced-choice guessing task in which they won or lost money, as well as a social interaction task in which they received acceptance and rejection feedback. Data were analyzed at both Cz and at a frontocentral region of interest (ROI) using techniques derived from classical test theory and generalizability theory. Results demonstrated good to excellent internal consistency of the RewP and FN within 20 trials in both tasks, in addition to convergent validity between the two tasks. Results from a regression-based approach to isolating activity specific to a single response demonstrated acceptable to good internal consistency within 20 trials in both tasks, while a subtraction-based approach (∆RewP) did not achieve acceptable internal consistency in either task. Internal consistency was not moderated by age and did not differ between Cz and the frontocentral ROI; however, the magnitudes of the RewP and FN were significantly associated with age at Cz but not at the ROI. This work replicates previous studies demonstrating good psychometric properties of the monetary RewP/FN and provides novel information about the psychometric properties of the social RewP/FN. These data support the use of reward-related ERPs elicited by multiple reward types in studies of biomarkers of psychopathology. Copyright © 2018 Elsevier B.V. All rights reserved.

Using brain potentials to understand prism adaptation: the error-related negativity and the P300

PubMed Central

MacLean, Stephane J.; Hassall, Cameron D.; Ishigami, Yoko; Krigolson, Olav E.; Eskes, Gail A.

2015-01-01

Prism adaptation (PA) is both a perceptual-motor learning task as well as a promising rehabilitation tool for visuo-spatial neglect (VSN)—a spatial attention disorder often experienced after stroke resulting in slowed and/or inaccurate motor responses to contralesional targets. During PA, individuals are exposed to prism-induced shifts of the visual-field while performing a visuo-guided reaching task. After adaptation, with goggles removed, visuomotor responding is shifted to the opposite direction of that initially induced by the prisms. This visuomotor aftereffect has been used to study visuomotor learning and adaptation and has been applied clinically to reduce VSN severity by improving motor responding to stimuli in contralesional (usually left-sided) space. In order to optimize PA's use for VSN patients, it is important to elucidate the neural and cognitive processes that alter visuomotor function during PA. In the present study, healthy young adults underwent PA while event-related potentials (ERPs) were recorded at the termination of each reach (screen-touch), then binned according to accuracy (hit vs. miss) and phase of exposure block (early, middle, late). Results show that two ERP components were evoked by screen-touch: an error-related negativity (ERN), and a P300. The ERN was consistently evoked on miss trials during adaptation, while the P300 amplitude was largest during the early phase of adaptation for both hit and miss trials. This study provides evidence of two neural signals sensitive to visual feedback during PA that may sub-serve changes in visuomotor responding. Prior ERP research suggests that the ERN reflects an error processing system in medial-frontal cortex, while the P300 is suggested to reflect a system for context updating and learning. Future research is needed to elucidate the role of these ERP components in improving visuomotor responses among individuals with VSN. PMID:26124715

Using brain potentials to understand prism adaptation: the error-related negativity and the P300.

PubMed

MacLean, Stephane J; Hassall, Cameron D; Ishigami, Yoko; Krigolson, Olav E; Eskes, Gail A

2015-01-01

Prism adaptation (PA) is both a perceptual-motor learning task as well as a promising rehabilitation tool for visuo-spatial neglect (VSN)-a spatial attention disorder often experienced after stroke resulting in slowed and/or inaccurate motor responses to contralesional targets. During PA, individuals are exposed to prism-induced shifts of the visual-field while performing a visuo-guided reaching task. After adaptation, with goggles removed, visuomotor responding is shifted to the opposite direction of that initially induced by the prisms. This visuomotor aftereffect has been used to study visuomotor learning and adaptation and has been applied clinically to reduce VSN severity by improving motor responding to stimuli in contralesional (usually left-sided) space. In order to optimize PA's use for VSN patients, it is important to elucidate the neural and cognitive processes that alter visuomotor function during PA. In the present study, healthy young adults underwent PA while event-related potentials (ERPs) were recorded at the termination of each reach (screen-touch), then binned according to accuracy (hit vs. miss) and phase of exposure block (early, middle, late). Results show that two ERP components were evoked by screen-touch: an error-related negativity (ERN), and a P300. The ERN was consistently evoked on miss trials during adaptation, while the P300 amplitude was largest during the early phase of adaptation for both hit and miss trials. This study provides evidence of two neural signals sensitive to visual feedback during PA that may sub-serve changes in visuomotor responding. Prior ERP research suggests that the ERN reflects an error processing system in medial-frontal cortex, while the P300 is suggested to reflect a system for context updating and learning. Future research is needed to elucidate the role of these ERP components in improving visuomotor responses among individuals with VSN.

ERP System Implementation: An Oil and Gas Exploration Sector Perspective

NASA Astrophysics Data System (ADS)

Mishra, Alok; Mishra, Deepti

Enterprise Resource Planning (ERP) systems provide integration and optimization of various business processes which leads to improved planning and decision quality, smoother coordination between business units resulting in higher efficiency, and quicker response time to customer demands and inquiries. This paper reports challenges, opportunities and outcome of ERP implementation in Oil & Gas exploration sector. This study will facilitate in understanding transition, constraints and implementation of ERP in this sector and also provide guidelines from lessons learned in this regard.

Transforming the Force: A Comparative Analysis of the Department of Defense’s (DOD’s) Enterprise Resource Planning (ERP) Systems

DTIC Science & Technology

2007-09-01

the smaller ERP companies that produce specialized ERPs for particular industries. Five former IBM employees founded SAP and created the first ERP...Computer Sciences Corporations (CSC), Price Waterhouse Coopers, EDS, and IBM [2]. Selecting the right integrators is critical because they are the link... IBM was chosen as the integrator for the NEMAIS pilot. 5. Pilot Results and Road Ahead Between late 1998 and early 2002, the four Navy pilots took

Enhanced recovery pathways optimize health outcomes and resource utilization: a meta-analysis of randomized controlled trials in colorectal surgery.

PubMed

Adamina, Michel; Kehlet, Henrik; Tomlinson, George A; Senagore, Anthony J; Delaney, Conor P

2011-06-01

Health care systems provide care to increasingly complex and elderly patients. Colorectal surgery is a prime example, with high volumes of major procedures, significant morbidity, prolonged hospital stays, and unplanned readmissions. This situation is exacerbated by an exponential rise in costs that threatens the stability of health care systems. Enhanced recovery pathways (ERP) have been proposed as a means to reduce morbidity and improve effectiveness of care. We have reviewed the evidence supporting the implementation of ERP in clinical practice. Medline, Embase, and the Cochrane library were searched for randomized, controlled trials comparing ERP with traditional care in colorectal surgery. Systematic reviews and papers on ERP based on data published in major surgical and anesthesiology journals were critically reviewed by international contributors, experienced in the development and implementation of ERP. A random-effect Bayesian meta-analysis was performed, including 6 randomized, controlled trials totalizing 452 patients. For patients adhering to ERP, length of stay decreased by 2.5 days (95% credible interval [CrI] -3.92 to -1.11), whereas 30-day morbidity was halved (relative risk, 0.52; 95% CrI, 0.36-0.73) and readmission was not increased (relative risk, 0.59; 95% CrI, 0.14-1.43) when compared with patients undergoing traditional care. Adherence to ERP achieves a reproducible improvement in the quality of care by enabling standardization of health care processes. Thus, while accelerating recovery and safely reducing hospital stay, ERPs optimize utilization of health care resources. ERPs can and should be routinely used in care after colorectal and other major gastrointestinal procedures. Copyright © 2011 Mosby, Inc. All rights reserved.

Patient satisfaction with the use of an enhanced recovery programme for primary arthroplasty

PubMed Central

Phillips, S; Parker, M; Carrannante, J; Hearth, MW

2013-01-01

Introduction Enhanced recovery programmes (ERPs) are increasingly being used for arthroplasty. One of the core aims of an ERP is to improve the quality of patient experience. However, there is currently no published evaluation of patient satisfaction in relation to this new programme of care within orthopaedic surgery. The aim of this study was to compare the ERP against the standard care programme (SCP) at one centre. Methods A satisfaction survey addressing patient opinions on the key objectives of the ERP was conducted by telephone, using a set script. Of the 226 patients contacted, 143 (63.3%) responded (69 from the ERP and 74 from the SCP). Of the respondents, 71 received a total hip arthroplasty and 72 a total knee arthroplasty. Patients were contacted at a mean time from operation to survey of 27.2 weeks. They were asked to rate satisfaction on a five-point scale and complete the EQ-5D™ health questionnaire (EuroQol, Rotterdam, Netherlands) to measure healthcare outcomes. Results The mean patient satisfaction score of 4.07 for speed of recovery in the ERP group was significantly higher than the SCP group’s score of 3.68 (p=0.037). Adjusting for the preoperative health score, the postoperative health score was higher for ERP patients at 74.1 compared with 64.7 for SCP patients (p=0.0029). Furthermore, the percentage of patients who had a better than expected recovery was significantly greater in the ERP group at 85.5% compared with 58.1% (p=0.0004) in the SCP group. Conclusions We believe that the previously established reduction in length of hospital stay delivered by ERPs is not achieved at the expense of the patient’s experience. PMID:24165340

Patient satisfaction with the use of an enhanced recovery programme for primary arthroplasty.

PubMed

Machin, J T; Phillips, S; Parker, M; Carrannante, J; Hearth, M W

2013-11-01

Enhanced recovery programmes (ErPs) are increasingly being used for arthroplasty. One of the core aims of an ErP is to improve the quality of patient experience. However, there is currently no published evaluation of patient satisfaction in relation to this new programme of care within orthopaedic surgery. The aim of this study was to compare the ErP against the standard care programme (SCP) at one centre. A satisfaction survey addressing patient opinions on the key objectives of the ErP was conducted by telephone, using a set script. Of the 226 patients contacted, 143 (63.3%) responded (69 from the ErP and 74 from the SCP). Of the respondents, 71 received a total hip arthroplasty and 72 a total knee arthroplasty. Patients were contacted at a mean time from operation to survey of 27.2 weeks. They were asked to rate satisfaction on a five-point scale and complete the EQ-5D™ health questionnaire (EuroQol, rotterdam, Netherlands) to measure healthcare outcomes. The mean patient satisfaction score of 4.07 for speed of recovery in the ErP group was significantly higher than the SCP group's score of 3.68 (p=0.037). Adjusting for the preoperative health score, the postoperative health score was higher for ErP patients at 74.1 compared with 64.7 for SCP patients (p=0.0029). Furthermore, the percentage of patients who had a better than expected recovery was significantly greater in the ErP group at 85.5% compared with 58.1% (p=0.0004) in the SCP group. We believe that the previously established reduction in length of hospital stay delivered by ErPs is not achieved at the expense of the patient's experience.

ERp29 Regulates ΔF508 and Wild-type Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Trafficking to the Plasma Membrane in Cystic Fibrosis (CF) and Non-CF Epithelial Cells*

PubMed Central

Suaud, Laurence; Miller, Katelyn; Alvey, Lora; Yan, Wusheng; Robay, Amal; Kebler, Catherine; Kreindler, James L.; Guttentag, Susan; Hubbard, Michael J.; Rubenstein, Ronald C.

2011-01-01

Sodium 4-phenylbutyrate (4PBA) improves the intracellular trafficking of ΔF508-CFTR in cystic fibrosis (CF) epithelial cells. The underlying mechanism is uncertain, but 4PBA modulates the expression of some cytosolic molecular chaperones. To identify other 4PBA-regulated proteins that might regulate ΔF508-CFTR trafficking, we performed a differential display RT-PCR screen on IB3-1 CF bronchiolar epithelial cells exposed to 4PBA. One transcript up-regulated by 4PBA encoded ERp29, a luminal resident of the endoplasmic reticulum (ER) thought to be a novel molecular chaperone. We tested the hypothesis that ERp29 is a 4PBA-regulated ER chaperone that influences ΔF508-CFTR trafficking. ERp29 mRNA and protein expression was significantly increased (∼1.5-fold) in 4PBA-treated IB3-1 cells. In Xenopus oocytes, ERp29 overexpression increased the functional expression of both wild-type and ΔF508-CFTR over 3-fold and increased wild-type cystic fibrosis transmembrane conductance regulator (CFTR) plasma membrane expression. In CFBE41o− WT-CFTR cells, expression of and short circuit currents mediated by CFTR decreased upon depletion of ERp29 as did maturation of newly synthesized CFTR. In IB3-1 cells, ΔF508-CFTR co-immunoprecipitated with endogenous ERp29, and overexpression of ERp29 led to increased ΔF508-CFTR expression at the plasma membrane. These data suggest that ERp29 is a 4PBA-regulated ER chaperone that regulates WT-CFTR biogenesis and can promote ΔF508-CFTR trafficking in CF epithelial cells. PMID:21525008

ERp29 regulates DeltaF508 and wild-type cystic fibrosis transmembrane conductance regulator (CFTR) trafficking to the plasma membrane in cystic fibrosis (CF) and non-CF epithelial cells.

PubMed

Suaud, Laurence; Miller, Katelyn; Alvey, Lora; Yan, Wusheng; Robay, Amal; Kebler, Catherine; Kreindler, James L; Guttentag, Susan; Hubbard, Michael J; Rubenstein, Ronald C

2011-06-17

Sodium 4-phenylbutyrate (4PBA) improves the intracellular trafficking of ΔF508-CFTR in cystic fibrosis (CF) epithelial cells. The underlying mechanism is uncertain, but 4PBA modulates the expression of some cytosolic molecular chaperones. To identify other 4PBA-regulated proteins that might regulate ΔF508-CFTR trafficking, we performed a differential display RT-PCR screen on IB3-1 CF bronchiolar epithelial cells exposed to 4PBA. One transcript up-regulated by 4PBA encoded ERp29, a luminal resident of the endoplasmic reticulum (ER) thought to be a novel molecular chaperone. We tested the hypothesis that ERp29 is a 4PBA-regulated ER chaperone that influences ΔF508-CFTR trafficking. ERp29 mRNA and protein expression was significantly increased (∼1.5-fold) in 4PBA-treated IB3-1 cells. In Xenopus oocytes, ERp29 overexpression increased the functional expression of both wild-type and ΔF508-CFTR over 3-fold and increased wild-type cystic fibrosis transmembrane conductance regulator (CFTR) plasma membrane expression. In CFBE41o- WT-CFTR cells, expression of and short circuit currents mediated by CFTR decreased upon depletion of ERp29 as did maturation of newly synthesized CFTR. In IB3-1 cells, ΔF508-CFTR co-immunoprecipitated with endogenous ERp29, and overexpression of ERp29 led to increased ΔF508-CFTR expression at the plasma membrane. These data suggest that ERp29 is a 4PBA-regulated ER chaperone that regulates WT-CFTR biogenesis and can promote ΔF508-CFTR trafficking in CF epithelial cells.

Seven years follow-up of early repolarisation patterns in French elite special forces.

PubMed

Roche, Nicolas-Charles; Massoure, Pierre-Laurent; Deharo, Jean-Claude; Paule, Philippe; Fourcade, Laurent

2018-06-01

The early repolarization pattern (ERP) may be a marker of increased risk for sudden cardiac death (SCD). Influence of ethnicity on the ERP has not been extensively studied. The aim of this study was to evaluate the epidemiology of ERP in a male multiethnic population. ECG analysis was performed among consecutive recruits from the French Foreign Legion. ERP was characterized by a J-point elevation ≥0.1 mV in two continuous inferior-lateral leads, and high amplitude early repolarization (HAER-potentially malignant pattern) by an elevation ≥0.2 mV. Ethnical affiliation and level of physical activity were recorded. A total of 2508 healthy men (24 ± 5 years old) from 105 different native countries were divided into three ethnic groups: 1689 Whites, 388 Afro-Caribbean, and 431 Asians. ERP was found in 489 recruits (19%), 14% in Whites, 33% in Afro-Caribbeans, and 27% in Asians without any difference according to age and physical activity. Sub-Saharan Africans or Caribbeans had the highest rate of ERP (30%), and Hispanics the lowest (8%). People from occidental countries, Middle East, Central Asia or India had a rate of 12%-18%, East and South-Asia 20%-25%. Madagascar was an exception with only 16% of ERP. HAER (2.9%) was more frequent among Asian recruits. After 5 ± 2 years of follow up, one SCD occurred in the ERP group (p = 0.042). This study reports a large multiethnic analysis of ERP. HAER was more frequent in recruits from East and South-East Asia where sudden unexplained nocturnal death syndrome is endemic. © 2018 Wiley Periodicals, Inc.

Vulnerability Management for an Enterprise Resource Planning System

NASA Astrophysics Data System (ADS)

Goel, Shivani; Kiran, Ravi; Garg, Deepak

2012-09-01

Enterprise resource planning (ERP) systems are commonly used in technical educational institutions(TEIs). ERP systems should continue providing services to its users irrespective of the level of failure. There could be many types of failures in the ERP systems. There are different types of measures or characteristics that can be defined for ERP systems to handle the levels of failure. Here in this paper, various types of failure levels are identified along with various characteristics which are concerned with those failures. The relation between all these is summarized. The disruptions causing vulnerabilities in TEIs are identified .A vulnerability management cycle has been suggested along with many commercial and open source vulnerability management tools. The paper also highlights the importance of resiliency in ERP systems in TEIs.

ERp57 interacts with conserved cysteine residues in the MHC class I peptide-binding groove.

PubMed

Antoniou, Antony N; Santos, Susana G; Campbell, Elaine C; Lynch, Sarah; Arosa, Fernando A; Powis, Simon J

2007-05-15

The oxidoreductase ERp57 is a component of the major histocompatibility complex (MHC) class I peptide-loading complex. ERp57 can interact directly with MHC class I molecules, however, little is known about which of the cysteine residues within the MHC class I molecule are relevant to this interaction. MHC class I molecules possess conserved disulfide bonds between cysteines 101-164, and 203-259 in the peptide-binding and alpha3 domain, respectively. By studying a series of mutants of these conserved residues, we demonstrate that ERp57 predominantly associates with cysteine residues in the peptide-binding domain, thus indicating ERp57 has direct access to the peptide-binding groove of MHC class I molecules during assembly.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

Clinch River - Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a study during the week of October 21-28, 1993, as described in the Statement of Work (SOW) document. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Due to serious reproduction/embryo abortion problems with the TVA daphnid cultures, TVA conducted tests during this study period using only fathead minnows. A split sample test using daphnids only will be scheduled during 1994 as a substitute for this study period. Surface water samples were collected by TVA Field Engineering personnelmore » from Poplar Creek Mile 2.9, Mile 4.3, and Mile 5.1 on October 20, 22, and 25. Samples were split and provided to the CR-ERP and TVA toxicology laboratories for testing. Exposure of test organisms to these samples resulted in no toxicity (survival or growth) in testing conducted by TVA.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simbeck, D.J.

Clinch River-Environmental Restoration Program (CR-ERP) personnel and Tennessee Valley Authority (TVA) personnel conducted a study during the week of October 21--28, 1993. The organisms specified for testing were larval fathead minnows, Pimephales promelas, and the daphnid, Ceriodaphnia dubia. Due to serious reproduction/embryo abortion problems with the TVA daphnid cultures, TVA conducted tests during this study period using only fathead minnows. Surface water samples were collected by TVA Field Engineering personnel from Poplar Creek Mile 2.9, Mile 4.3, and Mile 5.1 on October 20, 22, and 25. Samples were split and provided to the CR-ERP and TVA toxicology laboratories for testing.more » Exposure of test organisms to these samples resulted in no toxicity (survival or growth) in testing conducted by TVA. Attachments to this report include: Chain of custody forms -- originals; Toxicity test bench sheets and statistical analyses; and Reference toxicant test information.« less

A frontal cortex event-related potential driven by the basal forebrain

PubMed Central

Nguyen, David P; Lin, Shih-Chieh

2014-01-01

Event-related potentials (ERPs) are widely used in both healthy and neuropsychiatric conditions as physiological indices of cognitive functions. Contrary to the common belief that cognitive ERPs are generated by local activity within the cerebral cortex, here we show that an attention-related ERP in the frontal cortex is correlated with, and likely generated by, subcortical inputs from the basal forebrain (BF). In rats performing an auditory oddball task, both the amplitude and timing of the frontal ERP were coupled with BF neuronal activity in single trials. The local field potentials (LFPs) associated with the frontal ERP, concentrated in deep cortical layers corresponding to the zone of BF input, were similarly coupled with BF activity and consistently triggered by BF electrical stimulation within 5–10 msec. These results highlight the important and previously unrecognized role of long-range subcortical inputs from the BF in the generation of cognitive ERPs. DOI: http://dx.doi.org/10.7554/eLife.02148.001 PMID:24714497

Spatial and Time Domain Feature of ERP Speller System Extracted via Convolutional Neural Network.

PubMed

Yoon, Jaehong; Lee, Jungnyun; Whang, Mincheol

2018-01-01

Feature of event-related potential (ERP) has not been completely understood and illiteracy problem remains unsolved. To this end, P300 peak has been used as the feature of ERP in most brain-computer interface applications, but subjects who do not show such peak are common. Recent development of convolutional neural network provides a way to analyze spatial and temporal features of ERP. Here, we train the convolutional neural network with 2 convolutional layers whose feature maps represented spatial and temporal features of event-related potential. We have found that nonilliterate subjects' ERP show high correlation between occipital lobe and parietal lobe, whereas illiterate subjects only show correlation between neural activities from frontal lobe and central lobe. The nonilliterates showed peaks in P300, P500, and P700, whereas illiterates mostly showed peaks in around P700. P700 was strong in both subjects. We found that P700 peak may be the key feature of ERP as it appears in both illiterate and nonilliterate subjects.

Spatial and Time Domain Feature of ERP Speller System Extracted via Convolutional Neural Network

PubMed Central

2018-01-01

Feature of event-related potential (ERP) has not been completely understood and illiteracy problem remains unsolved. To this end, P300 peak has been used as the feature of ERP in most brain–computer interface applications, but subjects who do not show such peak are common. Recent development of convolutional neural network provides a way to analyze spatial and temporal features of ERP. Here, we train the convolutional neural network with 2 convolutional layers whose feature maps represented spatial and temporal features of event-related potential. We have found that nonilliterate subjects' ERP show high correlation between occipital lobe and parietal lobe, whereas illiterate subjects only show correlation between neural activities from frontal lobe and central lobe. The nonilliterates showed peaks in P300, P500, and P700, whereas illiterates mostly showed peaks in around P700. P700 was strong in both subjects. We found that P700 peak may be the key feature of ERP as it appears in both illiterate and nonilliterate subjects.

Event-related potential evidence of accessing gender stereotypes to aid source monitoring.

PubMed

Leynes, P Andrew; Crawford, Jarret T; Radebaugh, Anne M; Taranto, Elizabeth

2013-01-23

Source memory for the speaker's voice (male or female) was investigated when semantic knowledge (gender stereotypes) could and could not inform the episodic source judgment while event-related potentials (ERPs) were recorded. Source accuracy was greater and response times were faster when stereotypes could predict the speaker's voice at test. Recollection supported source judgments in both conditions as indicated by significant parietal "old/new" ERP effects (500-800ms). Prototypical late ERP effects (the right frontal "old/new" effect and the late posterior negativity, LPN) were evident when source judgment was based solely on episodic memory. However, these two late ERP effects were diminished and a novel, frontal-negative ERP with left-central topography was observed when stereotypes aided source judgments. This pattern of ERP activity likely reflects activation of left frontal or left temporal lobes when semantic knowledge, in the form of a gender stereotype, is accessed to inform the episodic source judgment. Copyright © 2012 Elsevier B.V. All rights reserved.

ERP system implementation in SMEs: exploring the influences of the SME context

NASA Astrophysics Data System (ADS)

Zach, Ondrej; Munkvold, Bjørn Erik; Håkon Olsen, Dag

2014-03-01

Small and medium-sized enterprises (SMEs) are increasingly implementing enterprise resource planning (ERP) systems. Compared to large enterprises, SMEs differ in a number of inherent characteristics, which are likely to impact the ERP system implementations. The purpose of this study is to explore these influences of the SME context on the ERP system implementation process. SME characteristics are synthesised from relevant literature and the influences of the contextual factors on various activities across the ERP life cycle are investigated. The study presents findings from a multiple case study of four SMEs. The ownership type of the companies and limited resources were identified as the most influential contextual factors. Among the ERP life-cycle phases, the implementation phase was affected most by the SME context. The case studies also illustrate the need for a more nuanced view on what should be considered general characteristics of SMEs; for example, regarding the level of IS knowledge, business processes, and market characteristics.

Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.

PubMed

Yang, Kai; Li, De-Feng; Wang, Xi'e; Liang, Jinzhao; Sitia, Roberto; Wang, Chih-Chen; Wang, Xi

2016-10-04

ERp44 controls the localization and transport of diverse proteins in the early secretory pathway. The mechanisms that allow client recognition and the source of the oxidative power for forming intermolecular disulfides are as yet unknown. Here we present the structure of ERp44 bound to a client, peroxiredoxin 4. Our data reveal that ERp44 binds the oxidized form of peroxiredoxin 4 via thiol-disulfide interchange reactions. The structure explains the redox-dependent recognition and characterizes the essential non-covalent interactions at the interface. The ERp44-Prx4 covalent complexes can be reduced by glutathione and protein disulfide isomerase family members in the ER, allowing the two components to recycle. This work provides insights into the mechanisms of thiol-mediated protein retention and indicates the key roles of ERp44 in this biochemical cycle to optimize oxidative folding and redox homeostasis. Copyright © 2016 Elsevier Ltd. All rights reserved.

Amplitude modulation of steady-state visual evoked potentials by event-related potentials in a working memory task

PubMed Central

Yao, Dezhong; Tang, Yu; Huang, Yilan; Su, Sheng

2009-01-01

Previous studies have shown that the amplitude and phase of the steady-state visual-evoked potential (SSVEP) can be influenced by a cognitive task, yet the mechanism of this influence has not been understood. As the event-related potential (ERP) is the direct neural electric response to a cognitive task, studying the relationship between the SSVEP and ERP would be meaningful in understanding this underlying mechanism. In this work, the traditional average method was applied to extract the ERP directly, following the stimulus of a working memory task, while a technique named steady-state probe topography was utilized to estimate the SSVEP under the simultaneous stimulus of an 8.3-Hz flicker and a working memory task; a comparison between the ERP and SSVEP was completed. The results show that the ERP can modulate the SSVEP amplitude, and for regions where both SSVEP and ERP are strong, the modulation depth is large. PMID:19960240

Event-related potentials, cognition, and behavior: a biological approach.

PubMed

Kotchoubey, Boris

2006-01-01

The prevailing cognitive-psychological accounts of event-related brain potentials (ERPs) assume that ERP components manifest information processing operations leading from stimulus to response. Since this view encounters numerous difficulties already analyzed in previous studies, an alternative view is presented here that regards cortical control of behavior as a repetitive sensorimotor cycle consisting of two phases: (i) feedforward anticipation and (ii) feedback cortical performance. This view allows us to interpret in an integrative manner numerous data obtained from very different domains of ERP studies: from biophysics of ERP waves to their relationship to the processing of language, in which verbal behavior is viewed as likewise controlled by the same two basic control processes: feedforward (hypothesis building) and feedback (hypothesis checking). The proposed approach is intentionally simplified, explaining numerous effects on the basis of few assumptions and relating several levels of analysis: neurophysiology, macroelectrical processes (i.e. ERPs), cognition and behavior. It can, therefore, be regarded as a first approximation to a general theory of ERPs.

Insights into MHC class I peptide loading from the structure of the tapasin/ERp57 heterodimer

PubMed Central

Dong, Gang; Wearsch, Pamela A.; Peaper, David R.; Cresswell, Peter; Reinisch, Karin M.

2009-01-01

SUMMARY Tapasin is a glycoprotein critical for loading Major Histocompatibility Complex (MHC) class I molecules with high affinity peptides. It functions within the multimeric peptide-loading complex (PLC) as a disulfide-linked, stable heterodimer with the thiol oxidoreductase ERp57, and this covalent interaction is required to support optimal PLC activity. Here we present the 2.6 Å resolution structure of the tapasin/ERp57 core of the PLC. The structure reveals the basis for the stable dimerization of tapasin and ERp57 and provides the first example of a protein disulfide isomerase family member interacting with a substrate. Mutational analysis identified a conserved surface on tapasin that interacts with MHC class I molecules and is critical for the peptide loading and editing function of the tapasin-ERp57 heterodimer. By combining the tapasin/ERp57 structure with those of other defined PLC components we present a molecular model that illuminates the processes involved in MHC class I peptide loading. PMID:19119025

A Big Bang versus a Small Bang Approach: A Case Study of the Expeditionary Combat Support System (ECSS) and the Maintenance, Repair, and Overhaul Initiative (MROi)

DTIC Science & Technology

resource planning (ERP) solution called the Expeditionary Combat Support System (ECSS), a big - bang approach. In early 2012, the ECSS program was cancelled...Repair, and Overhaul initiative (MROi), a small- bang approach, to increase enterprise visibility and efficiency across all three Air Logistics

The ErpA/NfuA complex builds an oxidation-resistant Fe-S cluster delivery pathway.

PubMed

Py, Béatrice; Gerez, Catherine; Huguenot, Allison; Vidaud, Claude; Fontecave, Marc; Ollagnier de Choudens, Sandrine; Barras, Frédéric

2018-05-18

Fe-S cluster-containing proteins occur in most organisms, wherein they assist in myriad processes from metabolism to DNA repair via gene expression and bioenergetic processes. Here, we used both in vitro and in vivo methods to investigate the capacity of the four Fe-S carriers, NfuA, SufA, ErpA, and IscA, to fulfill their targeting role under oxidative stress. Likewise, Fe-S clusters exhibited varying half-lives, depending on the carriers they were bound to; an NfuA-bound Fe-S cluster was more stable ( t ½ = 100 min) than those bound to SufA ( t ½ = 55 min), ErpA ( t ½ = 54 min), or IscA ( t ½ = 45 min). Surprisingly, the presence of NfuA further enhanced stability of the ErpA-bound cluster to t ½ = 90 min. Using genetic and plasmon surface resonance analyses, we showed that NfuA and ErpA interacted directly with client proteins, whereas IscA or SufA did not. Moreover, NfuA and ErpA interacted with one another. Given all of these observations, we propose an architecture of the Fe-S delivery network in which ErpA is the last factor that delivers cluster directly to most if not all client proteins. NfuA is proposed to assist ErpA under severely unfavorable conditions. A comparison with the strategy employed in yeast and eukaryotes is discussed. © 2018 Py et al.

47 CFR 22.1013 - Effective radiated power limitations.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... The effective radiated power (ERP) of transmitters in the Offshore Radiotelephone Service must not exceed the limits in this section. (a) Maximum power. The ERP of transmitters in this service must not exceed 1000 Watts under any circumstances. (b) Mobile transmitters. The ERP of mobile transmitters must...

47 CFR 22.759 - Power limit for BETRS.

Code of Federal Regulations, 2010 CFR

2010-10-01

... radio systems must not exceed the limits in this section. (a) Maximum ERP. The effective radiated power (ERP) of central office and rural subscriber station transmitters in BETRS must not exceed the applicable limits in this paragraph under any circumstances. Frequency range (MHz) Maximum ERP (watts) 152...

47 CFR 22.759 - Power limit for BETRS.

Code of Federal Regulations, 2011 CFR

2011-10-01

... radio systems must not exceed the limits in this section. (a) Maximum ERP. The effective radiated power (ERP) of central office and rural subscriber station transmitters in BETRS must not exceed the applicable limits in this paragraph under any circumstances. Frequency range (MHz) Maximum ERP (watts) 152...

75 FR 17874 - Digital Audio Broadcasting Systems and Their Impact on the Terrestrial Radio Broadcast Service

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... power (ERP), and implements interference mitigation and remediation procedures to resolve promptly..., and the interference mitigation and remediation procedures will make certain that permissible... ERP to more than 4% of authorized analog ERP. 4. Establishes interference remediation procedures that...

An empirical analysis of ERP adoption by oil and gas firms

NASA Astrophysics Data System (ADS)

Romero, Jorge

2005-07-01

Despite the growing popularity of enterprise-resource-planning (ERP) systems for the information technology infrastructure of large and medium-sized businesses, there is limited empirical evidence on the competitive benefits of ERP implementations. Case studies of individual firms provide insights but do not provide sufficient evidence to draw reliable inferences and cross-sectional studies of firms in multiple industries provide a broad-brush perspective of the performance effects associated with ERP installations. To narrow the focus to a specific competitive arena, I analyze the impact of ERP adoption on various dimensions of performance for firms in the Oil and Gas Industry. I selected the Oil and Gas Industry because several companies installed a specific type of ERP system, SAP R/3, during the period from 1990 to 2002. In fact, SAP was the dominant provider of enterprise software to oil and gas companies during this period. I evaluate performance of firms that implemented SAP R/3 relative to firms that did not adopt ERP systems in the pre-implementation, implementation and post-implementation periods. My analysis takes two different approaches, the first from a financial perspective and the second from a strategic perspective. Using the Sloan (General Motors) model commonly applied in financial statement analysis, I examine changes in performance for ERP-adopting firms versus non-adopting firms along the dimensions of asset utilization and return on sales. Asset utilization is more closely aligned with changes in leanness of operations, and return on sales is more closely aligned with customer-value-added. I test hypotheses related to the timing and magnitude of the impact of ERP implementation with respect to leanness of operations and customer value added. I find that SAP-adopting companies performed relatively better in terms of asset turnover than non-SAP-adopting companies during both the implementation and post-implementation periods and that SAP-adopting firms outperformed non-SAP-adopting firms in terms of return on sales during the post-implementation period. These findings indicate that the impact of ERP implementation on return on sales occurred after an assimilation period. I perform an analysis of the impact of ERP in the Oil and Gas Industry using strategic performance metrics described in Banker et al. (1996) including profitability, productivity, price recovery, product mix, and capacity utilization. My results show that the benefits obtained from ERP implementation in terms of productivity and capacity utilization are persistently positive during and after the installation.

Classification of unconscious like/dislike decisions: First results towards a novel application for BCI technology.

PubMed

Wriessnegger, S C; Hackhofer, D; Muller-Putz, G R

2015-01-01

More and more applications for BCI technology emerge that are not restricted to communication or control, like gaming, rehabilitation, Neuro-IS research, neuro-economics or security. In this context a so called passive BCI, a system that derives its outputs from arbitrary brain activity for enriching a human-machine interaction with implicit information on the actual user state will be used. Concretely EEG-based BCI technology enables the use of signals related to attention, intentions and mental state, without relying on indirect measures based on overt behavior or other physiological signals which is an important point e.g. in Neuromarketing research. The scope of this pilot EEG-study was to detect like/dislike decisions on car stimuli just by means of ERP analysis. Concretely to define user preferences concerning different car designs by implementing an offline BCI based on shrinkage LDA classification. Although classification failed in the majority of participants the elicited early (sub) conscious ERP components reflect user preferences for cars. In a broader sense this study should pave the way towards a "product design BCI" suitable for neuromarketing research.

ERP Project Management Lessons Learned

ERIC Educational Resources Information Center

Carroll, Timothy D.

2009-01-01

Implementing an enterprise resource planning (ERP) system is a major undertaking for any higher education institution, with many challenges along the way. More than three years ago, Roane State Community College began a journey to implement an ERP system. Roane State recently completed a very successful implementation of the SunGard Banner Student…

Stay on the ERP Treadmill!

ERIC Educational Resources Information Center

Panettieri, Joseph C.

2007-01-01

This article discusses University of Central Florida's proactive approach to enterprise resource planning (ERP) and highlights UCF's success with ERP. The article points out that much of this success comes from the strength and management experience of those in leadership positions at UCF, and from the expertise and strong credentials of the team…

30 CFR 75.1507 - Emergency Response Plan; refuge alternatives.

Code of Federal Regulations, 2011 CFR

2011-07-01

....1507 Emergency Response Plan; refuge alternatives. (a) The Emergency Response Plan (ERP) shall include... request and the District Manager may approve an alternative location in the ERP if mining involves two... constructed prior to an event in a secure space and an isolated atmosphere, the ERP shall specify that— (1...

ERPs and Eye Movements Reflect Atypical Visual Perception in Pervasive Developmental Disorder

ERIC Educational Resources Information Center

Kemner, Chantal; van Engeland, Herman

2006-01-01

Many studies of eye tracking or event-related brain potentials (ERPs) in subjects with Pervasive Developmental Disorder (PDD) have yielded inconsistent results on attentional processing. However, recent studies have indicated that there are specific abnormalities in early processing that are probably related to perception. ERP amplitudes in…

Knowledge Management ERP Curriculum Design/Mapping (Theory and Development Tools)

ERIC Educational Resources Information Center

Swanson, Zane; Hepner, Michelle

2011-01-01

This study proposes a knowledge management framework for developing and managing enterprise resource planning (ERP) curriculum within business schools. Both theory and a practical implementation are addressed. The knowledge management (KM) framework has two components which utilize ERP from a big picture curriculum overview and a ground level…

Neural Dynamics Underlying Event-Related Potentials

NASA Technical Reports Server (NTRS)

Shah, Ankoor S.; Bressler, Steven L.; Knuth, Kevin H.; Ding, Ming-Zhou; Mehta, Ashesh D.; Ulbert, Istvan; Schroeder, Charles E.

2003-01-01

There are two opposing hypotheses about the brain mechanisms underlying sensory event-related potentials (ERPs). One holds that sensory ERPs are generated by phase resetting of ongoing electroencephalographic (EEG) activity, and the other that they result from signal averaging of stimulus-evoked neural responses. We tested several contrasting predictions of these hypotheses by direct intracortical analysis of neural activity in monkeys. Our findings clearly demonstrate evoked response contributions to the sensory ERP in the monkey, and they suggest the likelihood that a mixed (Evoked/Phase Resetting) model may account for the generation of scalp ERPs in humans.

Combination of PCA and LORETA for sources analysis of ERP data: an emotional processing study

NASA Astrophysics Data System (ADS)

Hu, Jin; Tian, Jie; Yang, Lei; Pan, Xiaohong; Liu, Jiangang

2006-03-01

The purpose of this paper is to study spatiotemporal patterns of neuronal activity in emotional processing by analysis of ERP data. 108 pictures (categorized as positive, negative and neutral) were presented to 24 healthy, right-handed subjects while 128-channel EEG data were recorded. An analysis of two steps was applied to the ERP data. First, principal component analysis was performed to obtain significant ERP components. Then LORETA was applied to each component to localize their brain sources. The first six principal components were extracted, each of which showed different spatiotemporal patterns of neuronal activity. The results agree with other emotional study by fMRI or PET. The combination of PCA and LORETA can be used to analyze spatiotemporal patterns of ERP data in emotional processing.

Euclidean distance and Kolmogorov-Smirnov analyses of multi-day auditory event-related potentials: a longitudinal stability study

NASA Astrophysics Data System (ADS)

Durato, M. V.; Albano, A. M.; Rapp, P. E.; Nawang, S. A.

2015-06-01

The validity of ERPs as indices of stable neurophysiological traits is partially dependent on their stability over time. Previous studies on ERP stability, however, have reported diverse stability estimates despite using the same component scoring methods. This present study explores a novel approach in investigating the longitudinal stability of average ERPs—that is, by treating the ERP waveform as a time series and then applying Euclidean Distance and Kolmogorov-Smirnov analyses to evaluate the similarity or dissimilarity between the ERP time series of different sessions or run pairs. Nonlinear dynamical analysis show that in the absence of a change in medical condition, the average ERPs of healthy human adults are highly longitudinally stable—as evaluated by both the Euclidean distance and the Kolmogorov-Smirnov test.

Need for speed: evaluating slopes of OCD recovery in behavior therapy enhanced with d-cycloserine.

PubMed

Chasson, Gregory S; Buhlmann, Ulrike; Tolin, David F; Rao, Sowmya R; Reese, Hannah E; Rowley, Theresa; Welsh, Kaitlyn S; Wilhelm, Sabine

2010-07-01

Evidence suggests that the antibiotic d-cycloserine (DCS) enhances the treatment effects of exposure and response prevention (ERP) for Obsessive-Compulsive Disorder (OCD). Further, evidence suggests that the effects of DCS diminish partway through treatment, but it is unclear to what extent. In an effort to evaluate these issues, the current study re-analyzes data from a 10-session randomized controlled trial of ERP+DCS versus ERP+placebo in a sample of 22 adults with OCD. We analyzed repeated-measures mixed models with random slopes and intercepts across different intervals: sessions 1-10, 1-5, and 6-10. The results indicate that the course of ERP was 2.3 times faster over the full 10 sessions for the DCS compared to the placebo group, and nearly six times quicker in the first half of ERP. Further interpretation of the results suggests that DCS does not amplify the effects of ERP, but instead initiates treatment effects sooner in treatment. In addition, DCS does not necessarily lose its effect over repeated use, but instead may exhaust its maximum utility after effectively jump-starting ERP. Ultimately, DCS may provide a means for curtailing treatment costs, decreasing treatment dropout and refusal rates, and enhancing access to care. Copyright 2010 Elsevier Ltd. All rights reserved.

Trust at first sight: evidence from ERPs.

PubMed

Marzi, Tessa; Righi, Stefania; Ottonello, Sara; Cincotta, Massimo; Viggiano, Maria Pia

2014-01-01

We used event-related potentials (ERPs) to tap the temporal dynamics of first impressions based on face appearance. Participants were asked to evaluate briefly presented faces for trustworthiness and political choice. Behaviorally, participants were better at discriminating faces that were pre-rated as untrustworthy. The ERP results showed that the P100 component was enhanced for untrustworthy faces, consistently with the view that signals of potential threat are given precedence in neural processing. The enhanced ERP responses to untrustworthy faces persisted throughout the processing sequence and the amplitude of early posterior negativity (EPN), and subsequent late positive potential (LPP) was increased with respect to trustworthy faces which, in contrast, elicited an enhanced positivity around 150 ms on frontal sites. These ERP patterns were found specifically for the trustworthiness evaluation and not for the political decision task. Political decision yielded an increase in the N170 amplitude, reflecting a more demanding and taxing structural encoding. Similar ERP responses, as previously reported in the literature for facial expressions processing, were found throughout the entire time course specifically elicited by faces explicitly judged as untrustworthy. One possibility might be that evolution has provided the brain with a 'special toolkit' for trust evaluation that is fast and triggers ERPs related to emotional processing.

Neurocognitive mechanisms of statistical-sequential learning: what do event-related potentials tell us?

PubMed Central

Daltrozzo, Jerome; Conway, Christopher M.

2014-01-01

Statistical-sequential learning (SL) is the ability to process patterns of environmental stimuli, such as spoken language, music, or one’s motor actions, that unfold in time. The underlying neurocognitive mechanisms of SL and the associated cognitive representations are still not well understood as reflected by the heterogeneity of the reviewed cognitive models. The purpose of this review is: (1) to provide a general overview of the primary models and theories of SL, (2) to describe the empirical research – with a focus on the event-related potential (ERP) literature – in support of these models while also highlighting the current limitations of this research, and (3) to present a set of new lines of ERP research to overcome these limitations. The review is articulated around three descriptive dimensions in relation to SL: the level of abstractness of the representations learned through SL, the effect of the level of attention and consciousness on SL, and the developmental trajectory of SL across the life-span. We conclude with a new tentative model that takes into account these three dimensions and also point to several promising new lines of SL research. PMID:24994975

Post-repolarization refractoriness increases vulnerability to block and initiation of reentrant impulses in heterogeneous infarcted myocardium.

PubMed

Cabo, Candido

2015-10-01

Myocardial infarction causes remodeling of the tissue structure and the density and kinetics of several ion channels in the cell membrane. Heterogeneities in refractory period (ERP) have been shown to occur in the infarct border zone and have been proposed to lead to initiation of arrhythmias. The purpose of this study is to quantify the window of vulnerability (WV) to block and initiation of reentrant impulses in myocardium with ERP heterogeneities using computer simulations. We found that ERP transitions at the border between normal ventricular cells (NZ) with different ERPs are smooth, whereas ERP transitions between NZ and infarct border zone cells (IZ) are abrupt. The profile of the ERP transitions is a combination of electrotonic interaction between NZ and IZ cells and the characteristic post-repolarization refractoriness (PRR) of IZ cells. ERP heterogeneities between NZ and IZ cells are more vulnerable to block and initiation of reentrant impulses than ERP heterogeneities between NZ cells. The relationship between coupling intervals of premature impulses (V1V2) and coupling intervals between premature and first reentrant impulses (V2T1) at NZ/NZ and NZ/IZ borders is inverse (i.e. the longer the coupling intervals of premature impulses the shorter the coupling interval between the premature and first reentrant impulses); this is in contrast with the reported V1V2/V2T1 relationship measured during initiation of reentrant impulses in canine infarcted hearts which is direct. (1) ERP transitions at the NZ-IZ border are abrupt as a consequence of PRR; (2) PRR increases the vulnerability to block and initiation of reentrant impulses in heterogeneous myocardium; (3) V1V2/V2T1 relationships measured at ERP heterogeneities in the computer model and in experimental canine infarcts are not consistent. Therefore, it is likely that other mechanisms like micro and/or macro structural heterogeneities also contribute to initiation of reentrant impulses in infarcted hearts. Copyright © 2015 Elsevier Ltd. All rights reserved.

Multi-Tasking and Choice of Training Data Influencing Parietal ERP Expression and Single-Trial Detection-Relevance for Neuroscience and Clinical Applications.

PubMed

Kirchner, Elsa A; Kim, Su Kyoung

2018-01-01

Event-related potentials (ERPs) are often used in brain-computer interfaces (BCIs) for communication or system control for enhancing or regaining control for motor-disabled persons. Especially results from single-trial EEG classification approaches for BCIs support correlations between single-trial ERP detection performance and ERP expression. Hence, BCIs can be considered as a paradigm shift contributing to new methods with strong influence on both neuroscience and clinical applications. Here, we investigate the relevance of the choice of training data and classifier transfer for the interpretability of results from single-trial ERP detection. In our experiments, subjects performed a visual-motor oddball task with motor-task relevant infrequent ( targets ), motor-task irrelevant infrequent ( deviants ), and motor-task irrelevant frequent ( standards ) stimuli. Under dual-task condition, a secondary senso-motor task was performed, compared to the simple-task condition. For evaluation, average ERP analysis and single-trial detection analysis with different numbers of electrodes were performed. Further, classifier transfer was investigated between simple and dual task. Parietal positive ERPs evoked by target stimuli (but not by deviants) were expressed stronger under dual-task condition, which is discussed as an increase of task emphasis and brain processes involved in task coordination and change of task set. Highest classification performance was found for targets irrespective whether all 62, 6 or 2 parietal electrodes were used. Further, higher detection performance of targets compared to standards was achieved under dual-task compared to simple-task condition in case of training on data from 2 parietal electrodes corresponding to results of ERP average analysis. Classifier transfer between tasks improves classification performance in case that training took place on more varying examples (from dual task). In summary, we showed that P300 and overlaying parietal positive ERPs can successfully be detected while subjects are performing additional ongoing motor activity. This supports single-trial detection of ERPs evoked by target events to, e.g., infer a patient's attentional state during therapeutic intervention.

Multi-Tasking and Choice of Training Data Influencing Parietal ERP Expression and Single-Trial Detection—Relevance for Neuroscience and Clinical Applications

PubMed Central

Kirchner, Elsa A.; Kim, Su Kyoung

2018-01-01

Event-related potentials (ERPs) are often used in brain-computer interfaces (BCIs) for communication or system control for enhancing or regaining control for motor-disabled persons. Especially results from single-trial EEG classification approaches for BCIs support correlations between single-trial ERP detection performance and ERP expression. Hence, BCIs can be considered as a paradigm shift contributing to new methods with strong influence on both neuroscience and clinical applications. Here, we investigate the relevance of the choice of training data and classifier transfer for the interpretability of results from single-trial ERP detection. In our experiments, subjects performed a visual-motor oddball task with motor-task relevant infrequent (targets), motor-task irrelevant infrequent (deviants), and motor-task irrelevant frequent (standards) stimuli. Under dual-task condition, a secondary senso-motor task was performed, compared to the simple-task condition. For evaluation, average ERP analysis and single-trial detection analysis with different numbers of electrodes were performed. Further, classifier transfer was investigated between simple and dual task. Parietal positive ERPs evoked by target stimuli (but not by deviants) were expressed stronger under dual-task condition, which is discussed as an increase of task emphasis and brain processes involved in task coordination and change of task set. Highest classification performance was found for targets irrespective whether all 62, 6 or 2 parietal electrodes were used. Further, higher detection performance of targets compared to standards was achieved under dual-task compared to simple-task condition in case of training on data from 2 parietal electrodes corresponding to results of ERP average analysis. Classifier transfer between tasks improves classification performance in case that training took place on more varying examples (from dual task). In summary, we showed that P300 and overlaying parietal positive ERPs can successfully be detected while subjects are performing additional ongoing motor activity. This supports single-trial detection of ERPs evoked by target events to, e.g., infer a patient's attentional state during therapeutic intervention. PMID:29636660

Processing temporal agreement in a tenseless language: an ERP study of Mandarin Chinese.

PubMed

Qiu, Yinchen; Zhou, Xiaolin

2012-03-29

Human languages are equipped with an impressive repertoire of time-encoding devices which vary significantly across different cultures. Previous research on temporal processing has focused on morphosyntactic processes in Indo-European languages. This study investigated the neural correlates of temporal processing in Mandarin Chinese, a language that is not morphologically marked for tense. In a sentence acceptability judgment task, we manipulated the agreement between semantically enriched temporal adverbs or a highly grammaticalized aspectual particle (-guo) and temporal noun phrases. Disagreement of both the temporal adverbs and the aspectual particle elicited a centro-parietal P600 effect in event-related potentials (ERPs) whereas only disagreeing temporal adverbs evoked an additional broadly distributed N400 effect. Moreover, a sustained negativity effect was observed on both the words following the critical ones and the last words in sentences with temporal disagreement. These results reveal both commonalities and differences between Chinese and Indo-European languages in temporal agreement processing. In particular, we demonstrate that temporal reference in Chinese relies on both lexical semantics and morphosyntactic processes and that the level of grammaticalization of linguistic devices representing similar temporal information is reflected in differential ERP responses. Copyright © 2012 Elsevier B.V. All rights reserved.

The processing of consonants and vowels during letter identity and letter position assignment in visual-word recognition: an ERP study.

PubMed

Vergara-Martínez, Marta; Perea, Manuel; Marín, Alejandro; Carreiras, Manuel

2011-09-01

Recent research suggests that there is a processing distinction between consonants and vowels in visual-word recognition. Here we conjointly examine the time course of consonants and vowels in processes of letter identity and letter position assignment. Event related potentials (ERPs) were recorded while participants read words and pseudowords in a lexical decision task. The stimuli were displayed under different conditions in a masked priming paradigm with a 50-ms SOA: (i) identity/baseline condition e.g., chocolate-CHOCOLATE); (ii) vowels-delayed condition (e.g., choc_l_te-CHOCOLATE); (iii) consonants-delayed condition (cho_o_ate-CHOCOLATE); (iv) consonants-transposed condition (cholocate-CHOCOLATE); (v) vowels-transposed condition (chocalote-CHOCOLATE), and (vi) unrelated condition (editorial-CHOCOLATE). Results showed earlier ERP effects and longer reaction times for the delayed-letter compared to the transposed-letter conditions. Furthermore, at early stages of processing, consonants may play a greater role during letter identity processing. Differences between vowels and consonants regarding letter position assignment are discussed in terms of a later phonological level involved in lexical retrieval. Copyright © 2010 Elsevier Inc. All rights reserved.

The role of inhibition for working memory processes: ERP evidence from a short-term storage task.

PubMed

Getzmann, Stephan; Wascher, Edmund; Schneider, Daniel

2018-05-01

Human working memory is the central unit for short-term storage of information. In addition to the selection and adequate storage of relevant information, the suppression of irrelevant stimuli from the environment seems to be of importance for working memory processes. To learn more about the interplay of information uptake and inhibition of irrelevant information, the present study used ERP measures and a short-term storage and retrieval task, in which pairs of either numbers or letters had to be compared. Random sequences of four stimuli (two numbers and two letters) were presented, with either the numbers or the letters being relevant for comparison. The analysis of ERPs to each of the four stimuli indicated more pronounced P2 and P3b amplitudes for relevant than irrelevant stimuli. In contrast, the N2 (reflecting inhibitory control) was only elicited by irrelevant stimuli. Moreover, the N2 amplitude of the second irrelevant stimulus was associated with behavioral performance, indicating the importance of inhibition of task-irrelevant stimuli for working memory processes. In sum, the findings demonstrate the role of cognitive control mechanisms for protecting relevant contents in working memory against irrelevant information. © 2017 Society for Psychophysiological Research.

Buffering effect of money priming on negative emotions—An ERP study.

PubMed

Ma, Qingguo; Hu, Yue; Pei, Guanxiong; Xiang, Ting

2015-10-08

Recent studies have accumulated evidences that merely reminding people of money could lead to behavioral changes including alleviating both physical pain and social distress. However, the underlying neural mechanism regarding such pain-buffering effect of money is not clear. In this paper, we applied event-related potentials (ERP) to investigate the neural effect of money reminders on induced negative emotions. Subjects were first primed of money images and subsequently viewing unpleasant pictures, while EEG was recorded. Behavioral results suggested a reduced sensitivity to unpleasant pictures after participants being reminded of money. ERP data showed that money priming, compared to neutral priming, generated a larger N2 in frontal and posterior areas, reflecting an endogenous mental conflict and the recruitment of attention resources, and a smaller late positive potential (LPP) in parietal and occipital regions, indicating a regulating process of negative emotions. Additionally, how brain responded to money and neutral stimuli were also examined, indexed by "N170-P2" complex. This study provided additional neurophysiological evidences to support previous behavioral researches on money priming and discussed the two separated neural dynamic stages involved in emotion regulation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Socio-emotionally Significant Experience and Children’s Processing of Irrelevant Auditory Stimuli

PubMed Central

Schermerhorn, Alice C.; Bates, John E.; Puce, Aina; Molfese, Dennis L.

2017-01-01

Theory and research indicate considerable influence of socio-emotionally significant experiences on children’s functioning and adaptation. In the current study, we examined neurophysiological correlates of children’s allocation of information processing resources to socio-emotionally significant events, specifically, simulated marital interactions. We presented 9- to 11-year-old children (n = 24; 11 females) with 15 videos of interactions between two actors posing as a married couple. Task-irrelevant brief auditory probes were presented during the videos, and event-related potentials (ERPs) elicited to the auditory probes were measured. As hypothesized, exposure to higher levels of interparental conflict was associated with smaller P1, P2, and N2 ERPs to the probes. This finding is consistent with the idea that children who had been exposed to more interparental conflict attended more to the videos and diverted fewer cognitive resources to processing the probes, thereby producing smaller ERPs to the probes. In addition, smaller N2s were associated with more child behavior problems, suggesting that allocating fewer processing resources to the probes was associated with more problem behavior. Results are discussed in terms of implications of socio-emotionally significant experiences for children’s processing of interpersonal interactions. PMID:27993611

Time course of processing emotional stimuli as a function of perceived emotional intelligence, anxiety, and depression

PubMed Central

Fisher, Joscelyn E.; Sass, Sarah M.; Heller, Wendy; Silton, Rebecca Levin; Edgar, J. Christopher; Stewart, Jennifer L.; Miller, Gregory A.

2014-01-01

An individual’s self-reported abilities to attend to, understand, and reinterpret emotional situations or events have been associated with anxiety and depression, but it is unclear how these abilities affect the processing of emotional stimuli, especially in individuals with these symptoms. The present study recorded event-related brain potentials while individuals reporting features of anxiety and depression completed an emotion-word Stroop task. Results indicated that anxious apprehension, anxious arousal, and depression were associated with self-reported emotion abilities, consistent with prior literature. Additionally, lower anxious apprehension and greater reported emotional clarity were related to slower processing of negative stimuli indexed by event-related potentials (ERPs). Higher anxious arousal and reported attention to emotion were associated with ERP evidence of early attention to all stimuli regardless of emotional content. Reduced later engagement with stimuli was also associated with anxious arousal and with clarity of emotions. Depression was not differentially associated with any emotion processing stage indexed by ERPs. Research in this area may lead to the development of therapies that focus on minimization of anxiety in order to foster successful emotion regulation. PMID:20677866

How to get statistically significant effects in any ERP experiment (and why you shouldn't).

PubMed

Luck, Steven J; Gaspelin, Nicholas

2017-01-01

ERP experiments generate massive datasets, often containing thousands of values for each participant, even after averaging. The richness of these datasets can be very useful in testing sophisticated hypotheses, but this richness also creates many opportunities to obtain effects that are statistically significant but do not reflect true differences among groups or conditions (bogus effects). The purpose of this paper is to demonstrate how common and seemingly innocuous methods for quantifying and analyzing ERP effects can lead to very high rates of significant but bogus effects, with the likelihood of obtaining at least one such bogus effect exceeding 50% in many experiments. We focus on two specific problems: using the grand-averaged data to select the time windows and electrode sites for quantifying component amplitudes and latencies, and using one or more multifactor statistical analyses. Reanalyses of prior data and simulations of typical experimental designs are used to show how these problems can greatly increase the likelihood of significant but bogus results. Several strategies are described for avoiding these problems and for increasing the likelihood that significant effects actually reflect true differences among groups or conditions. © 2016 Society for Psychophysiological Research.

Early auditory evoked potential is modulated by selective attention and related to individual differences in visual working memory capacity.

PubMed

Giuliano, Ryan J; Karns, Christina M; Neville, Helen J; Hillyard, Steven A

2014-12-01

A growing body of research suggests that the predictive power of working memory (WM) capacity for measures of intellectual aptitude is due to the ability to control attention and select relevant information. Crucially, attentional mechanisms implicated in controlling access to WM are assumed to be domain-general, yet reports of enhanced attentional abilities in individuals with larger WM capacities are primarily within the visual domain. Here, we directly test the link between WM capacity and early attentional gating across sensory domains, hypothesizing that measures of visual WM capacity should predict an individual's capacity to allocate auditory selective attention. To address this question, auditory ERPs were recorded in a linguistic dichotic listening task, and individual differences in ERP modulations by attention were correlated with estimates of WM capacity obtained in a separate visual change detection task. Auditory selective attention enhanced ERP amplitudes at an early latency (ca. 70-90 msec), with larger P1 components elicited by linguistic probes embedded in an attended narrative. Moreover, this effect was associated with greater individual estimates of visual WM capacity. These findings support the view that domain-general attentional control mechanisms underlie the wide variation of WM capacity across individuals.

The lasting memory enhancements of retrospective attention.

PubMed

Reaves, Sarah; Strunk, Jonathan; Phillips, Shekinah; Verhaeghen, Paul; Duarte, Audrey

2016-07-01

Behavioral research has shown that spatial cues that orient attention toward task relevant items being maintained in visual short-term memory (VSTM) enhance item memory accuracy. However, it is unknown if these retrospective attentional cues ("retro-cues") enhance memory beyond typical short-term memory delays. It is also unknown whether retro-cues affect the spatial information associated with VSTM representations. Emerging evidence suggests that processes that affect short-term memory maintenance may also affect long-term memory (LTM) but little work has investigated the role of attention in LTM. In the current event-related potential (ERP) study, we investigated the duration of retrospective attention effects and the impact of retrospective attention manipulations on VSTM representations. Results revealed that retro-cueing improved both VSTM and LTM memory accuracy and that posterior maximal ERPs observed during VSTM maintenance predicted subsequent LTM performance. N2pc ERPs associated with attentional selection were attenuated by retro-cueing suggesting that retrospective attention may disrupt maintenance of spatial configural information in VSTM. Collectively, these findings suggest that retrospective attention can alter the structure of memory representations, which impacts memory performance beyond short-term memory delays. Copyright © 2016 Elsevier B.V. All rights reserved.

The relationship between brain reaction and English reading tests for non-native English speakers.

PubMed

Cheng, Pei-Wen; Tian, Yu-Jie; Kuo, Ting-Hua; Sun, Koun-Tem

2016-07-01

This research analyzed the brain activity of non-native English speakers while engaged in English reading tests. The brain wave event-related potentials (ERPs) of participants were used to analyze the difference between making correct and incorrect choices on English reading test items. Three English reading tests of differing levels were designed and 20 participants, 10 males and 10 females whose ages ranged from 20 to 24, voluntarily participated in the experiment. Experimental results were analyzed by performing independent t-tests on the ERPs of participants for gender, difficulty level, and correct versus wrong options. Participants who chose incorrect options elicited a larger N600, verifying results found in the literature. Another interesting result was found: For incorrectly answered items, different areas of brain showing a significant difference in ERPs between the chosen and non-chosen options corresponded to gender differences; for males, this area was located in the right hemisphere whereas for females, it was located in the left. Experimental results imply that non-native English speaking males and females employ different areas of the brain to comprehend the meaning of difficult items. Copyright © 2016 Elsevier B.V. All rights reserved.

A real-time detector system for precise timing of audiovisual stimuli.

PubMed

Henelius, Andreas; Jagadeesan, Sharman; Huotilainen, Minna

2012-01-01

The successful recording of neurophysiologic signals, such as event-related potentials (ERPs) or event-related magnetic fields (ERFs), relies on precise information of stimulus presentation times. We have developed an accurate and flexible audiovisual sensor solution operating in real-time for on-line use in both auditory and visual ERP and ERF paradigms. The sensor functions independently of the used audio or video stimulus presentation tools or signal acquisition system. The sensor solution consists of two independent sensors; one for sound and one for light. The microcontroller-based audio sensor incorporates a novel approach to the detection of natural sounds such as multipart audio stimuli, using an adjustable dead time. This aids in producing exact markers for complex auditory stimuli and reduces the number of false detections. The analog photosensor circuit detects changes in light intensity on the screen and produces a marker for changes exceeding a threshold. The microcontroller software for the audio sensor is free and open source, allowing other researchers to customise the sensor for use in specific auditory ERP/ERF paradigms. The hardware schematics and software for the audiovisual sensor are freely available from the webpage of the authors' lab.

Semantic processing during morphological priming: an ERP study.

PubMed

Beyersmann, Elisabeth; Iakimova, Galina; Ziegler, Johannes C; Colé, Pascale

2014-09-04

Previous research has yielded conflicting results regarding the onset of semantic processing during morphological priming. The present study was designed to further explore the time-course of morphological processing using event-related potentials (ERPs). We conducted a primed lexical decision study comparing a morphological (LAVAGE - laver [washing - wash]), a semantic (LINGE - laver [laundry - wash]), an orthographic (LAVANDE - laver [lavender - wash]), and an unrelated control condition (HOSPICE - laver [nursing home - wash]), using the same targets across the four priming conditions. The behavioral data showed significant effects of morphological and semantic priming, with the magnitude of morphological priming being significantly larger than the magnitude of semantic priming. The ERP data revealed significant morphological but no semantic priming at 100-250 ms. Furthermore, a reduction of the N400 amplitude in the morphological condition compared to the semantic and orthographic condition demonstrates that the morphological priming effect was not entirely due to the semantic or orthographic overlap between the prime and the target. The present data reflect an early process of semantically blind morphological decomposition, and a later process of morpho-semantic decomposition, which we discuss in the context of recent morphological processing theories. Copyright © 2014 Elsevier B.V. All rights reserved.

Lexical enhancement during prime-target integration: ERP evidence from matched-case identity priming.

PubMed

Vergara-Martínez, Marta; Gómez, Pablo; Jiménez, María; Perea, Manuel

2015-06-01

A number of experiments have revealed that matched-case identity PRIME-TARGET pairs are responded to faster than mismatched-case identity prime-TARGET pairs for pseudowords (e.g., JUDPE-JUDPE < judpe-JUDPE), but not for words (JUDGE-JUDGE = judge-JUDGE). These findings suggest that prime-target integration processes are enhanced when the stimuli tap onto lexical representations, overriding physical differences between the stimuli (e.g., case). To track the time course of this phenomenon, we conducted an event-related potential (ERP) masked-priming lexical decision experiment that manipulated matched versus mismatched case identity in words and pseudowords. The behavioral results replicated previous research. The ERP waves revealed that matched-case identity-priming effects were found at a very early time epoch (N/P150 effects) for words and pseudowords. Importantly, around 200 ms after target onset (N250), these differences disappeared for words but not for pseudowords. These findings suggest that different-case word forms (lower- and uppercase) tap into the same abstract representation, leading to prime-target integration very early in processing. In contrast, different-case pseudoword forms are processed as two different representations. This word-pseudoword dissociation has important implications for neural accounts of visual-word recognition.

Evidences from Rewarding System, FRN and P300 Effect in Internet-Addiction in Young People SHORT TITLE: Rewarding System and EEG in Internet-Addiction

PubMed Central

Venturella, Irene; Finocchiaro, Roberta

2017-01-01

The present research explored rewarding bias and attentional deficits in Internet addiction (IA) based on the IAT (Internet Addiction Test) construct, during an attentional inhibitory task (Go/NoGo task). Event-related Potentials (ERPs) effects (Feedback Related Negativity (FRN) and P300) were monitored in concomitance with Behavioral Activation System (BAS) modulation. High-IAT young participants showed specific responses to IA-related cues (videos representing online gambling and videogames) in terms of cognitive performance (decreased Response Times, RTs; and Error Rates, ERs) and ERPs modulation (decreased FRN and increased P300). Consistent reward and attentional biases was adduced to explain the cognitive “gain” effect and the anomalous response in terms of both feedback behavior (FRN) and attentional (P300) mechanisms in high-IAT. In addition, BAS and BAS-Reward subscales measures were correlated with both IAT and ERPs variations. Therefore, high sensitivity to IAT may be considered as a marker of dysfunctional reward processing (reduction of monitoring) and cognitive control (higher attentional values) for specific IA-related cues. More generally, a direct relationship among reward-related behavior, Internet addiction and BAS attitude was suggested. PMID:28704978

Neural correlates of foreign-language learning in childhood: a 3-year longitudinal ERP study.

PubMed

Ojima, Shiro; Nakamura, Naoko; Matsuba-Kurita, Hiroko; Hoshino, Takahiro; Hagiwara, Hiroko

2011-01-01

A foreign language (a language not spoken in one's community) is difficult to master completely. Early introduction of foreign-language (FL) education during childhood is becoming a standard in many countries. However, the neural process of child FL learning still remains largely unknown. We longitudinally followed 322 school-age children with diverse FL proficiency for three consecutive years, and acquired children's ERP responses to FL words that were semantically congruous or incongruous with the preceding picture context. As FL proficiency increased, various ERP components previously reported in mother-tongue (L1) acquisition (such as a broad negativity, an N400, and a late positive component) appeared sequentially, critically in an identical order to L1 acquisition. This finding was supported not only by cross-sectional analyses of children at different proficiency levels but also by longitudinal analyses of the same children over time. Our data are consistent with the hypothesis that FL learning in childhood reproduces identical developmental stages in an identical order to L1 acquisition, suggesting that the nature of the child's brain itself may determine the normal course of FL learning. Future research should test the generalizability of the results in other aspects of language such as syntax.

When fear forms memories: threat of shock and brain potentials during encoding and recognition.

PubMed

Weymar, Mathias; Bradley, Margaret M; Hamm, Alfons O; Lang, Peter J

2013-03-01

The anticipation of highly aversive events is associated with measurable defensive activation, and both animal and human research suggests that stress-inducing contexts can facilitate memory. Here, we investigated whether encoding stimuli in the context of anticipating an aversive shock affects recognition memory. Event-related potentials (ERPs) were measured during a recognition test for words that were encoded in a font color that signaled threat or safety. At encoding, cues signaling threat of shock, compared to safety, prompted enhanced P2 and P3 components. Correct recognition of words encoded in the context of threat, compared to safety, was associated with an enhanced old-new ERP difference (500-700 msec; centro-parietal), and this difference was most reliable for emotional words. Moreover, larger old-new ERP differences when recognizing emotional words encoded in a threatening context were associated with better recognition, compared to words encoded in safety. Taken together, the data indicate enhanced memory for stimuli encoded in a context in which an aversive event is merely anticipated, which could assist in understanding effects of anxiety and stress on memory processes. Copyright © 2012 Elsevier Ltd. All rights reserved.

47 CFR 22.1013 - Effective radiated power limitations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... not exceed 100 Watts. The ERP of mobile transmitters, when located within 32 kilometers (20 miles) of the 4.8 kilometer (3 mile) limit, must not exceed 25 Watts. The ERP of airborne mobile stations must.... The ERP of offshore stations located within 128.8 kilometers (80 miles) of the main transmitter...

47 CFR 22.1013 - Effective radiated power limitations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... not exceed 100 Watts. The ERP of mobile transmitters, when located within 32 kilometers (20 miles) of the 4.8 kilometer (3 mile) limit, must not exceed 25 Watts. The ERP of airborne mobile stations must.... The ERP of offshore stations located within 128.8 kilometers (80 miles) of the main transmitter...

The Strategic Academic Enterprise: Why ERPs Will No Longer Be Adequate

ERIC Educational Resources Information Center

Jones, Mary

2009-01-01

In the 1970s and '80s, manufacturing firms began purchasing centralized administrative software--"Enterprise Resource Planning (ERP) systems"--to support their infrastructure needs. In the 1990s, higher education adopted the term ERP to define the back-office systems used by institutions to meet their most pressing business needs--typically those…

Electrophysiological Correlates of Impaired Reading in Dyslexic Pre-Adolescent Children

ERIC Educational Resources Information Center

Araujo, Susana; Bramao, Ines; Faisca, Luis; Petersson, Karl Magnus; Reis, Alexandra

2012-01-01

In this study, event related potentials (ERPs) were used to investigate the extent to which dyslexics (aged 9-13 years) differ from normally reading controls in early ERPs, which reflect prelexical orthographic processing, and in late ERPs, which reflect implicit phonological processing. The participants performed an implicit reading task, which…

Drivers and Effects of Enterprise Resource Planning Post-Implementation Learning

ERIC Educational Resources Information Center

Chang, Hsiu-Hua; Chou, Huey-Wen

2011-01-01

The use of enterprise resource planning (ERP) systems has grown enormously since 1990, but the failure to completely learn how to use them continues to produce disappointing results. Today's rapidly changing business environment and the integrative applications of ERP systems force users to continuously learn new skills after ERP implementation.…

47 CFR 90.303 - Availability of frequencies.

Code of Federal Regulations, 2011 CFR

2011-10-01

...)(2)(ii) of this section, base stations shall be limited to a maximum effective radiated power (ERP... Kull, and Arthur Kill, the maximum ERP and antenna height shall be limited to the entries specified in....0″ W). (iii) Mobile stations shall be limited to 100 watts ERP in areas of operation extending...

47 CFR 22.565 - Transmitting power limits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... channels listed in § 22.561 must not exceed the limits in this section. (a) Maximum ERP. The effective radiated power (ERP) of base and fixed transmitters must not exceed the applicable limits in this paragraph under any circumstances. Frequency range (MHz) Maximum ERP (watts) 152-153 1400 157-159 150 454-455 3500...

14 CFR 431.45 - Mishap investigation plan and emergency response plan.

Code of Federal Regulations, 2011 CFR

2011-01-01

... shall also submit an emergency response plan (ERP) that contains procedures for informing the affected public of a planned RLV mission. An acceptable ERP satisfies the requirements of paragraph (e) of this section. The MIP and ERP shall be signed by an individual authorized to sign and certify the application...

47 CFR 22.565 - Transmitting power limits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... channels listed in § 22.561 must not exceed the limits in this section. (a) Maximum ERP. The effective radiated power (ERP) of base and fixed transmitters must not exceed the applicable limits in this paragraph under any circumstances. Frequency range (MHz) Maximum ERP (watts) 152-153 1400 157-159 150 454-455 3500...

Does ERP Hands-On Experience Help Students Learning Business Process Concepts?

ERIC Educational Resources Information Center

Rienzo, Thomas; Han, Bernard

2011-01-01

Over the past decade, more and more business schools are attempting to teach business processes (BPs) by using enterprise resource planning (ERP) software in their curricula. Currently, most studies involving ERP software in the academy have concentrated on learning and teaching via self-assessment surveys or curriculum integration. This research…

Temporal Dynamics of Awareness for Facial Identity Revealed with ERP

ERIC Educational Resources Information Center

Genetti, Melanie; Khateb, Asaid; Heinzer, Severine; Michel, Christoph M.; Pegna, Alan J.

2009-01-01

In this study, we investigated the scalp recorded event-related potential (ERP) responses related to visual awareness. A backward masking procedure was performed while high-density EEG recordings were carried out. Subjects were asked to detect a familiar face, presented at durations that varied parametrically between 16 and 266 ms. ERPs were…

University ERP Implementation in Germany: Qualitative Exploratory Case Study of Administrative Staff Experiences

ERIC Educational Resources Information Center

Thelen, Anja

2015-01-01

Enterprise Resource Planning (ERP) implementations are expensive, time-consuming, and often do not lead to the expected outcome of integrated IT systems. Many German universities are implementing ERP systems as Campus Management Systems (CMS) and a solution to any problem, need, or requirement the organization has. This exploratory case study…

Gender Differences in Memory Processing: Evidence from Event-Related Potentials to Faces

ERIC Educational Resources Information Center

Guillem, F.; Mograss, M.

2005-01-01

This study investigated gender differences on memory processing using event-related potentials (ERPs). Behavioral data and ERPs were recorded in 16 males and 10 females during a recognition memory task for faces. The behavioral data results showed that females performed better than males. Gender differences on ERPs were evidenced over anterior…

To Use or Not to Use--ERP Resistance Is the Question: The Roles of Tacit Knowledge and Complexity

ERIC Educational Resources Information Center

Freeze, Ronald D.; Schmidt, Pamela J.

2015-01-01

Enterprise Resource Planning (ERP) systems in business environments demand multidisciplinary understanding and collaboration between functional departments. The traditional educational paradigm isolates the learning of each functional discipline as if business people operated in functional isolation. ERP system value can only be realized by…

Mindfulness based cognitive therapy may improve emotional processing in bipolar disorder: pilot ERP and HRV study.

PubMed

Howells, Fleur M; Laurie Rauch, H G; Ives-Deliperi, Victoria L; Horn, Neil R; Stein, Dan J

2014-06-01

Emotional processing in bipolar disorder (BD) is impaired. We aimed to measure the effects of mindfulness based cognitive-behavioral therapy (MBCT) in BD on emotional processing, as measured by event related potentials (ERP) and by heart rate variability (HRV). ERP and HRV were recorded during the completion of a visual matching task, which included object matching, affect matching, and affect labeling. Individuals with BD (n = 12) were compared with controls (n = 9) to obtain baseline data prior to the individuals with BD undergoing an 8-week MBCT intervention. ERP and HRV recording was repeated after the MBCT intervention in BD. Participants with BD had exaggerated ERP N170 amplitude and increased HRV HF peak compared to controls, particularly during the affect matching condition. After an 8-week MBCT intervention, participants with BD showed attenuation of ERP N170 amplitude and reduced HRV HF peak. Our findings support findings from the literature emphasizing that emotional processing in BD is altered, and suggesting that MBCT may improve emotional processing in BD.

Gaze-independent ERP-BCIs: augmenting performance through location-congruent bimodal stimuli

PubMed Central

Thurlings, Marieke E.; Brouwer, Anne-Marie; Van Erp, Jan B. F.; Werkhoven, Peter

2014-01-01

Gaze-independent event-related potential (ERP) based brain-computer interfaces (BCIs) yield relatively low BCI performance and traditionally employ unimodal stimuli. Bimodal ERP-BCIs may increase BCI performance due to multisensory integration or summation in the brain. An additional advantage of bimodal BCIs may be that the user can choose which modality or modalities to attend to. We studied bimodal, visual-tactile, gaze-independent BCIs and investigated whether or not ERP components’ tAUCs and subsequent classification accuracies are increased for (1) bimodal vs. unimodal stimuli; (2) location-congruent vs. location-incongruent bimodal stimuli; and (3) attending to both modalities vs. to either one modality. We observed an enhanced bimodal (compared to unimodal) P300 tAUC, which appeared to be positively affected by location-congruency (p = 0.056) and resulted in higher classification accuracies. Attending either to one or to both modalities of the bimodal location-congruent stimuli resulted in differences between ERP components, but not in classification performance. We conclude that location-congruent bimodal stimuli improve ERP-BCIs, and offer the user the possibility to switch the attended modality without losing performance. PMID:25249947

Mapping the ER Interactome: The P Domains of Calnexin and Calreticulin as Plurivalent Adapters for Foldases and Chaperones.

PubMed

Kozlov, Guennadi; Muñoz-Escobar, Juliana; Castro, Karla; Gehring, Kalle

2017-09-05

The lectin chaperones calreticulin (CRT) and calnexin (CNX) contribute to the folding of glycoproteins in the ER by recruiting foldases such as the protein disulfide isomerase ERp57 and the peptidyl prolyl cis-trans isomerase CypB. Recently, CRT was shown to interact with the chaperone ERp29. Here, we show that ERp29 directly binds to the P domain of CNX. Crystal structures of the D domain of ERp29 in complex with the P domains from CRT and calmegin, a tissue-specific CNX homolog, reveal a commonality in the mechanism of binding whereby the tip of the P domain functions as a plurivalent adapter to bind a variety of folding factors. We show that mutation of a single residue, D348 in CNX, abrogates binding to ERp29 as well as ERp57 and CypB. The structural diversity of the accessory factors suggests that these chaperones became specialized for glycoprotein folding through convergent evolution of their P-domain binding sites. Copyright © 2017 Elsevier Ltd. All rights reserved.

Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study.

PubMed

Barbancho, Miguel A; Berthier, Marcelo L; Navas-Sánchez, Patricia; Dávila, Guadalupe; Green-Heredia, Cristina; García-Alberca, José M; Ruiz-Cruces, Rafael; López-González, Manuel V; Dawid-Milner, Marc S; Pulvermüller, Friedemann; Lara, J Pablo

2015-01-01

Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials. Copyright © 2015 Elsevier Inc. All rights reserved.

Event related potentials to digit learning: tracking neurophysiologic changes accompanying recall performance.

PubMed

Jongsma, Marijtje L A; Gerrits, Niels J H M; van Rijn, Clementina M; Quiroga, Rodrigo Quian; Maes, Joseph H R

2012-07-01

The aim of this study was to track recall performance and event-related potentials (ERPs) across multiple trials in a digit-learning task. When a sequence is practiced by repetition, the number of errors typically decreases and a learning curve emerges. Until now, almost all ERP learning and memory research has focused on effects after a single presentation and, therefore, fails to capture the dynamic changes that characterize a learning process. However, the current study used a free-recall task in which a sequence of ten auditory digits was presented repeatedly. Auditory sequences of ten digits were presented in a logical order (control sequences) or in a random order (experimental sequences). Each sequence was presented six times. Participants had to reproduce the sequence after each presentation. EEG recordings were made at the time of the digit presentations. Recall performance for the control sequences was close to asymptote right after the first learning trial, whereas performance for the experimental sequences initially displayed primacy and recency effects. However, these latter effects gradually disappeared over the six repetitions, resulting in near-asymptotic recall performance for all digits. The performance improvement for the middle items of the list was accompanied by an increase in P300 amplitude, implying a close correspondence between this ERP component and the behavioral data. These results, which were discussed in the framework of theories on the functional significance of the P300 amplitude, add to the scarce empirical data on the dynamics of ERP responses in the process of intentional learning. Copyright © 2011 Elsevier B.V. All rights reserved.

Temporal prediction modulates the evaluative processing of "good" action feedback: An electrophysiological study.

PubMed

Kimura, Kenta; Kimura, Motohiro; Iwaki, Sunao

2016-10-01

The present study aimed to investigate whether or not the evaluative processing of action feedback can be modulated by temporal prediction. For this purpose, we examined the effects of the predictability of the timing of action feedback on an ERP effect that indexed the evaluative processing of action feedback, that is, an ERP effect that has been interpreted as a feedback-related negativity (FRN) elicited by "bad" action feedback or a reward positivity (RewP) elicited by "good" action feedback. In two types of experimental blocks, the participants performed a gambling task in which they chose one of two cards and received an action feedback that indicated monetary gain or loss. In fixed blocks, the time interval between the participant's choice and the onset of the action feedback was fixed at 0, 500, or 1,000 ms in separate blocks; thus, the timing of action feedback was predictable. In mixed blocks, the time interval was randomly chosen from the same three intervals with equal probability; thus, the timing was less predictable. The results showed that the FRN/RewP was smaller in mixed than fixed blocks for the 0-ms interval trial, whereas there was no difference between the two block types for the 500-ms and 1,000-ms interval trials. Interestingly, the smaller FRN/RewP was due to the modulation of gain ERPs rather than loss ERPs. These results suggest that temporal prediction can modulate the evaluative processing of action feedback, and particularly good feedback, such as that which indicates monetary gain. © 2016 Society for Psychophysiological Research.

Preserved frontal memorial processing for pictures in patients with mild cognitive impairment.

PubMed

Ally, Brandon A; McKeever, Joshua D; Waring, Jill D; Budson, Andrew E

2009-08-01

Amnestic mild cognitive impairment (aMCI) has been conceptualized as a transitional stage between healthy aging and Alzheimer's disease (AD). Therefore, understanding which aspects of memory are impaired and which remain relatively intact in these patients can be useful in determining who will ultimately go on to develop AD, and subsequently designing interventions to help patients live more engaged and independent lives. The dual-process model posits that recognition memory decisions can rely on either familiarity or recollection. Whereas research is fairly consistent in showing impaired recollection in patients with aMCI, the results have been mixed regarding familiarity. A noted difference between these studies investigating familiarity has been stimulus type. The goal of the current investigation was to use high-density event-related potentials (ERPs) to help elucidate the neural correlates of recognition decisions in patients with aMCI for words and pictures. We also hoped to help answer the question of whether patients can rely on familiarity to support successful recognition. Patients and controls participated in separate recognition memory tests of words and pictures while ERPs were recorded during retrieval. Results showed that ERP components typically associated with familiarity and retrieval monitoring were similar between groups for pictures. However, these components were diminished in the patient group for words. Based on recent work, the authors discuss the possibility that implicit conceptual priming could have contributed to the enhanced ERP correlate of familiarity. Further, the authors address the possibility that enhanced retrieval monitoring may be needed to modulate increased familiarity engendered by pictures.

Neural correlates of multimodal metaphor comprehension: Evidence from event-related potentials and time-frequency decompositions.

PubMed

Ma, Qingguo; Hu, Linfeng; Xiao, Can; Bian, Jun; Jin, Jia; Wang, Qiuzhen

2016-11-01

The present study examined the event-related potential (ERP) and time-frequency components correlates with the comprehension process of multimodal metaphors that were represented by the combination of "a vehicle picture+a written word of an animal". Electroencephalogram data were recorded when participants decided whether the metaphor using an animal word for the vehicle rendered by a picture was appropriate or not. There were two conditions: appropriateness (e.g., sport utility vehicles+tiger) vs. inappropriateness (e.g., sport utility vehicles+cat). The ERP results showed that inappropriate metaphor elicited larger N300 (280-360ms) and N400 (380-460ms) amplitude than appropriate one, which were different from previous exclusively verbal metaphor studies that rarely observed the N300 effect. A P600 (550-750ms) was also observed and larger in appropriate metaphor condition. Besides, the time-frequency principal component analysis revealed that two independent theta activities indexed the separable processes (retrieval of semantic features and semantic integration) underlying the N300 and N400. Delta band was also induced within a later time window and best characterized the integration process underlying P600. These results indicate the specific cognitive mechanism of multimodal metaphor comprehension that is different from verbal metaphor processing, mirrored by several separable processes indexed by ERP components and time-frequency components. The present study extends the metaphor research by uncovering the functional roles of delta and theta as well as their unique contributions to the ERP components during multimodal metaphor comprehension. Copyright © 2016 Elsevier B.V. All rights reserved.

Specific Reaction Patterns to Distinct Positive Emotional Cues Related to Incentive Motivation in Dependence of the Taq1A-Polymorphism: Molecular Genetic Associations of Early and Late Event-Related Potentials.

PubMed

Munk, Aisha J L; Wielpuetz, Catrin; Osinsky, Roman; Müller, Erik M; Grant, Phillip; Hennig, Jürgen

2016-01-01

Early and late event-related potential (ERP) responses, representing early subconscious and late motivational processes, were recorded for positive emotional words related to 'wanting' and 'liking', in dependence of the dopamine-related Taq1A genotype (ANKK1/DRD2). Research suggests that 'wanting' as opposed to 'liking' is related to dopaminergic processes. Therefore, it was hypothesized that risk allele carriers of the Taq1A polymorphism exhibit late ERP changes in reaction to words representing incentive motivation, i.e. 'wanting' (word categories 'lust' and 'anticipation'), but not to words representing 'liking' ('closeness'). Seventy-two male participants performed an emotional-word Stroop task during EEG recording and were genotyped according to the Taq1A polymorphism of ANKK1/DRD2. Positive emotional words related to anticipation and lust revealed blunted responses in the late positive potential (LPP) in carriers of the A1 allele, an effect absent in response to 'liking'-related words. These differences were not evident in the earlier posterior negativity (EPN). As no differences in dependence of the Taq1A genotype were observed in reaction to 'wanting'- and 'liking'-related words in the EPN, but merely in the LPP, it can be assumed that incentive-motivational stimuli only modify motivation-related ERP responses in carriers of the A1 allele of the Taq1A polymorphism, indicating the role of dopamine in late ERP components. © 2016 S. Karger AG, Basel.

The influence of directed attention at encoding on source memory retrieval in the young and old: an ERP study.

PubMed

Dulas, Michael R; Duarte, Audrey

2013-03-15

Neuroimaging evidence suggests that older adults exhibit deficits in frontally-mediated strategic retrieval processes, such as post-retrieval monitoring. Behavioral research suggests that explicitly directing attention toward source features during encoding may improve source memory for both young and older adults and alleviate age-related source memory impairments, in part, by reducing demands on post-retrieval monitoring. We investigated this hypothesis in the present event-related potential (ERP) study. Young and older adults attended to either objects and their presented color (source) or to the object alone during study and made color source memory decisions at test. We attempted to match performance between groups by halving the memory load for older adults. Behavioral results showed that, while direction of attention to object and color improved source memory for both groups, older adults benefited less than the young. ERPs revealed that demands on late right frontal effects, indicative of post-retrieval monitoring, were similarly reduced by directed attention at encoding for both groups. However, older adults showed reduced ERP correlates of recollection (parietal old-new effect), as well as a sustained widespread negativity, potentially indicative of memory searches for perceptual details in the face of impaired recollection. These results suggest that older adults, like the young, can engage in post-retrieval monitoring when source details are difficult to recover. However, impaired recollection may underlie persistent age-related source memory deficits, even when encoding is supported via directed attention. Copyright © 2013 Elsevier B.V. All rights reserved.

MULTIDISCIPLINARY PERSPECTIVES IN EVENT-RELATED BRAIN POTENTIAL RESEARCH

EPA Science Inventory

The volume is the Proceedings of the Fourth International Congress on Event-Related Potentials of the Brain (EPIC-IV) held in Hendersonville, North Carolina in April 1976. It contains 118 manuscripts including critical reviews and data reports in the following areas of ERP resear...

Enterprise resource planning for hospitals.

PubMed

van Merode, Godefridus G; Groothuis, Siebren; Hasman, Arie

2004-06-30

Integrated hospitals need a central planning and control system to plan patients' processes and the required capacity. Given the changes in healthcare one can ask the question what type of information systems can best support these healthcare delivery organizations. We focus in this review on the potential of enterprise resource planning (ERP) systems for healthcare delivery organizations. First ERP systems are explained. An overview is then presented of the characteristics of the planning process in hospital environments. Problems with ERP that are due to the special characteristics of healthcare are presented. The situations in which ERP can or cannot be used are discussed. It is suggested to divide hospitals in a part that is concerned only with deterministic processes and a part that is concerned with non-deterministic processes. ERP can be very useful for planning and controlling the deterministic processes.

Single-trial detection of visual evoked potentials by common spatial patterns and wavelet filtering for brain-computer interface.

PubMed

Tu, Yiheng; Huang, Gan; Hung, Yeung Sam; Hu, Li; Hu, Yong; Zhang, Zhiguo

2013-01-01

Event-related potentials (ERPs) are widely used in brain-computer interface (BCI) systems as input signals conveying a subject's intention. A fast and reliable single-trial ERP detection method can be used to develop a BCI system with both high speed and high accuracy. However, most of single-trial ERP detection methods are developed for offline EEG analysis and thus have a high computational complexity and need manual operations. Therefore, they are not applicable to practical BCI systems, which require a low-complexity and automatic ERP detection method. This work presents a joint spatial-time-frequency filter that combines common spatial patterns (CSP) and wavelet filtering (WF) for improving the signal-to-noise (SNR) of visual evoked potentials (VEP), which can lead to a single-trial ERP-based BCI.

Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1

PubMed Central

van Anken, Eelco; Pena, Florentina; Hafkemeijer, Nicole; Christis, Chantal; Romijn, Edwin P.; Grauschopf, Ulla; Oorschot, Viola M. J.; Pertel, Thomas; Engels, Sander; Ora, Ari; Lástun, Viorica; Glockshuber, Rudi; Klumperman, Judith; Heck, Albert J. R.; Luban, Jeremy; Braakman, Ineke

2009-01-01

Plasma cells daily secrete their own mass in antibodies, which fold and assemble in the endoplasmic reticulum (ER). To reach these levels, cells require pERp1, a novel lymphocyte-specific small ER-resident protein, which attains expression levels as high as BiP when B cells differentiate into plasma cells. Although pERp1 has no homology with known ER proteins, it does contain a CXXC motif typical for oxidoreductases. In steady state, the CXXC cysteines are locked by two parallel disulfide bonds with a downstream C(X)6C motif, and pERp1 displays only modest oxidoreductase activity. pERp1 emerged as a dedicated folding factor for IgM, associating with both heavy and light chains and promoting assembly and secretion of mature IgM. PMID:19805154

Re-examination of Chinese semantic processing and syntactic processing: evidence from conventional ERPs and reconstructed ERPs by residue iteration decomposition (RIDE).

PubMed

Wang, Fang; Ouyang, Guang; Zhou, Changsong; Wang, Suiping

2015-01-01

A number of studies have explored the time course of Chinese semantic and syntactic processing. However, whether syntactic processing occurs earlier than semantics during Chinese sentence reading is still under debate. To further explore this issue, an event-related potentials (ERPs) experiment was conducted on 21 native Chinese speakers who read individually-presented Chinese simple sentences (NP1+VP+NP2) word-by-word for comprehension and made semantic plausibility judgments. The transitivity of the verbs was manipulated to form three types of stimuli: congruent sentences (CON), sentences with a semantically violated NP2 following a transitive verb (semantic violation, SEM), and sentences with a semantically violated NP2 following an intransitive verb (combined semantic and syntactic violation, SEM+SYN). The ERPs evoked from the target NP2 were analyzed by using the Residue Iteration Decomposition (RIDE) method to reconstruct the ERP waveform blurred by trial-to-trial variability, as well as by using the conventional ERP method based on stimulus-locked averaging. The conventional ERP analysis showed that, compared with the critical words in CON, those in SEM and SEM+SYN elicited an N400-P600 biphasic pattern. The N400 effects in both violation conditions were of similar size and distribution, but the P600 in SEM+SYN was bigger than that in SEM. Compared with the conventional ERP analysis, RIDE analysis revealed a larger N400 effect and an earlier P600 effect (in the time window of 500-800 ms instead of 570-810ms). Overall, the combination of conventional ERP analysis and the RIDE method for compensating for trial-to-trial variability confirmed the non-significant difference between SEM and SEM+SYN in the earlier N400 time window. Converging with previous findings on other Chinese structures, the current study provides further precise evidence that syntactic processing in Chinese does not occur earlier than semantic processing.

Please Reduce Cycle Time

DTIC Science & Technology

2014-12-01

observed an ERP system implementation that encountered this exact model. The modified COTS software worked and passed the acceptance tests but never... software -intensive program. We decided to create a very detailed master sched- ule with multiple supporting subschedules that linked and Implementing ...processes in place as part of the COTS implementation . For hardware , COTS can also present some risks. Many pro- grams use COTS computers and servers

Test Area C-64 Range Environmental Assessment, Revision 1

DTIC Science & Technology

2010-10-01

DOI U.S. Department of the Interior DNL Day–Night Average Sound Level DU Depleted Uranium EBD Environmental Baseline Document EIAP Environmental...vulnerability, burning sensitivity, drop tests, bullet impact tests, sympathetic detonation tests, advanced warhead design tests, and depleted uranium (DU...land back to range use. Source: U.S. Air Force, 2009 DU = depleted uranium ; ERP = Environmental Restoration Program; LUC = land use control; RW

An Exploratory Study on the Application of Multiple Intelligences to MBA Andragogy with Particular Reference to ERP-Controlling Configuration Course

ERIC Educational Resources Information Center

Gaikwad, Sophia S.; Bharathi, S. Vijayakumar

2018-01-01

The purpose of this study is to elicit the application of Multiple Intelligences (MI) theory to a course taught in the MBA Andragogy. Administered to a sample of 47 students of the first year MBA Information Technology Business Management (ITBM) program at a private university in India the study brought out certain interesting implications.…

Differentiating weak ties and strong ties among external sources of influences for enterprise resource planning (ERP) adoption

NASA Astrophysics Data System (ADS)

Aubert, Benoit; Léger, Pierre-Majorique; Larocque, Denis

2012-05-01

Enterprise resource planning (ERP) systems represent a major IT adoption decision. ERP adoption decisions, in the chemicals and allied products sectors, were examined between 1994 and 2005. Networks of strong ties and weak ties partners are investigated. Results show that neighbouring companies linked with strong ties can have an influence on organisations making such adoption decision. Past decisions made by major trading partners have a significant influence on the decision to adopt an ERP system for a given organisation. This reflects the complex nature of the knowledge required for such adoption.

Electrophysiological evidence for phenomenal consciousness.

PubMed

Revonsuo, Antti; Koivisto, Mika

2010-09-01

Abstract Recent evidence from event-related brain potentials (ERPs) lends support to two central theses in Lamme's theory. The earliest ERP correlate of visual consciousness appears over posterior visual cortex around 100-200 ms after stimulus onset. Its scalp topography and time window are consistent with recurrent processing in the visual cortex. This electrophysiological correlate of visual consciousness is mostly independent of later ERPs reflecting selective attention and working memory functions. Overall, the ERP evidence supports the view that phenomenal consciousness of a visual stimulus emerges earlier than access consciousness, and that attention and awareness are served by distinct neural processes.

Evaluation of the ERP dispersion model using Darlington tracer-study data. Report No. 90-200-K

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, S.C.

1990-01-01

In this study, site-boundary atmospheric dilution factors calculated by the atmospheric dispersion model used in the ERP (Emergency Response Planning) computer code were compared to data collected during the Darlington tracer study. The purpose of this comparison was to obtain estimates of model uncertainty under a variety of conditions. This report provides background on ERP, the ERP dispersion model and the Darlington tracer study. Model evaluation techniques are discussed briefly, and the results of the comparison of model calculations with the field data are presented and reviewed.

A Regulatory Circuit Composed of a Transcription Factor, IscR, and a Regulatory RNA, RyhB, Controls Fe-S Cluster Delivery.

PubMed

Mandin, Pierre; Chareyre, Sylvia; Barras, Frédéric

2016-09-20

Fe-S clusters are cofactors conserved through all domains of life. Once assembled by dedicated ISC and/or SUF scaffolds, Fe-S clusters are conveyed to their apo-targets via A-type carrier proteins (ATCs). Escherichia coli possesses four such ATCs. ErpA is the only ATC essential under aerobiosis. Recent studies reported a possible regulation of the erpA mRNA by the small RNA (sRNA) RyhB, which controls the expression of many genes under iron starvation. Surprisingly, erpA has not been identified in recent transcriptomic analysis of the iron starvation response, thus bringing into question the actual physiological significance of the putative regulation of erpA by RyhB. Using an sRNA library, we show that among 26 sRNAs, only RyhB represses the expression of an erpA-lacZ translational fusion. We further demonstrate that this repression occurs during iron starvation. Using mutational analysis, we show that RyhB base pairs to the erpA mRNA, inducing its disappearance. In addition, IscR, the master regulator of Fe-S homeostasis, represses expression of erpA at the transcriptional level when iron is abundant, but depleting iron from the medium alleviates this repression. The conjunction of transcriptional derepression by IscR and posttranscriptional repression by RyhB under Fe-limiting conditions is best described as an incoherent regulatory circuit. This double regulation allows full expression of erpA at iron concentrations for which Fe-S biogenesis switches from the ISC to the SUF system. We further provide evidence that this regulatory circuit coordinates ATC usage to iron availability. Regulatory small RNAs (sRNAs) have emerged as major actors in the control of gene expression in the last few decades. Relatively little is known about how these regulators interact with classical transcription factors to coordinate genetic responses. We show here how an sRNA, RyhB, and a transcription factor, IscR, regulate expression of an essential gene, erpA, in the bacterium E. coli ErpA is involved in the biogenesis of Fe-S clusters, an important class of cofactors involved in a plethora of cellular reactions. Interestingly, we show that RyhB and IscR repress expression of erpA under opposite conditions in regard to iron concentration, forming a regulatory circuit called an "incoherent network." This incoherent network serves to maximize expression of erpA at iron concentrations where it is most needed. Altogether, our study paves the way for a better understanding of mixed regulatory networks composed of RNAs and transcription factors. Copyright © 2016 Mandin et al.

Proposing a New Framework and an Innovative Approach to Teaching Reengineering and ERP Implementation Concepts

ERIC Educational Resources Information Center

Pellerin, Robert; Hadaya, Pierre

2008-01-01

Recognizing the need to teach ERP implementation and business process reengineering (BPR) concepts simultaneously, as well as the pedagogical limitations of the case teaching method and simulation tools, the objective of this study is to propose a new framework and an innovative teaching approach to improve the ERP training experience for IS…

Effects of Rhyme and Spelling Patterns on Auditory Word ERPs Depend on Selective Attention to Phonology

ERIC Educational Resources Information Center

Yoncheva, Yuliya N.; Maurer, Urs; Zevin, Jason D.; McCandliss, Bruce D.

2013-01-01

ERP responses to spoken words are sensitive to both rhyming effects and effects of associated spelling patterns. Are such effects automatically elicited by spoken words or dependent on selectively attending to phonology? To address this question, ERP responses to spoken word pairs were investigated under two equally demanding listening tasks that…

The Drivers of ERP Implementation and Its Impact on Organizational Capabilities and Performance and Customer Value

ERIC Educational Resources Information Center

Hwang, Woosang

2011-01-01

In a constantly changing global business environment, firms have no other choice but to continually expand their capabilities and sharpen their competitive edge. Toward this goal, an increasing number of organizations are turning to Enterprise Resource Planning (ERP) systems. An ERP system utilizes various kinds of information processing…

Inadequate and Infrequent Are Not Alike: ERPs to Deviant Prosodic Patterns in Spoken Sentence Comprehension

ERIC Educational Resources Information Center

Mietz, Anja; Toepel, Ulrike; Ischebeck, Anja; Alter, Kai

2008-01-01

The current study on German investigates Event-Related brain Potentials (ERPs) for the perception of sentences with intonations which are infrequent (i.e. vocatives) or inadequate in daily conversation. These ERPs are compared to the processing correlates for sentences in which the syntax-to-prosody relations are congruent and used frequently…

Factors Influencing Post-Adoptive Enterprise Resource Planning (ERP) Utilization

ERIC Educational Resources Information Center

McGinnis, Thomas C.

2011-01-01

Organizations expend a great deal of time, effort and money on the implementation of enterprise resource planning (ERP) systems. They are considered the price of entry for large organizations to do business. Yet the success rate of ERP systems is poor. IS literature suggests that one possible reason for this is the underutilization of these…

47 CFR 90.545 - TV/DTV interference protection criteria.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contour (41 dBµV/m) (88.5 kilometers or 55.0 miles) of the DTV station. (b) Maximum ERP and HAAT. The maximum effective radiated power (ERP) and the antenna height above average terrain (HAAT) of the proposed... determined using the methods described in this section. (1) Each base station is limited to a maximum ERP of...

47 CFR 5.85 - Frequencies and policy governing their assignment.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Stations within 4.8 kilometers (3 statute miles) with 50 watts or more average ERP in the primary plane of... statute miles) with 1 kW or more average ERP in the primary plane of polarization in the azimuthal... more average ERP in the primary plane of polarization in the azimuthal direction of the Monitoring...

47 CFR 2.1091 - Radiofrequency radiation exposure evaluation: mobile devices.

Code of Federal Regulations, 2011 CFR

2011-10-01

... their effective radiated power (ERP) is 1.5 watts or more, or if they operate at frequencies above 1.5 GHz and their ERP is 3 watts or more. Unlicensed personal communications service devices, unlicensed... exposure prior to equipment authorization or use if their ERP is 3 watts or more or if they meet the...

47 CFR 90.279 - Power limitations applicable to the 421-430 MHz band.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the 421-430 MHz band will be subject to Effective Radiated Power (ERP) and Effective Antenna Height (EAH) limitations as shown in the table below. ERP is defined as the product of the power supplied to... height above mean sea level. Limits of Effective Radiated Power (ERP) Corresponding to Effective Antenna...

47 CFR 22.911 - Cellular geographic service area.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the SAB is calculated as a function of effective radiated power (ERP) and antenna center of radiation...: d is the radial distance in kilometers h is the radial antenna HAAT in meters p is the radial ERP in... the radial distance in kilometers h is the radial antenna HAAT in meters p is the radial ERP in Watts...

Increased Error-Related Negativity (ERN) in Childhood Anxiety Disorders: ERP and Source Localization

ERIC Educational Resources Information Center

Ladouceur, Cecile D.; Dahl, Ronald E.; Birmaher, Boris; Axelson, David A.; Ryan, Neal D.

2006-01-01

Background: In this study we used event-related potentials (ERPs) and source localization analyses to track the time course of neural activity underlying response monitoring in children diagnosed with an anxiety disorder compared to age-matched low-risk normal controls. Methods: High-density ERPs were examined following errors on a flanker task…

Development of Action Monitoring through Adolescence into Adulthood: ERP and Source Localization

ERIC Educational Resources Information Center

Ladouceur, Cecile D.; Dahl, Ronald E.; Carter, Cameron S.

2007-01-01

In this study we examined the development of three action monitoring event-related potentials (ERPs)--the error-related negativity (ERN/Ne), error positivity (P[subscript E]) and the N2--and estimated their neural sources. These ERPs were recorded during a flanker task in the following groups: early adolescents (mean age = 12 years), late…

Investigation of ERP Teaching and Practitioner Experiences Related to ISO 9000 Core Standards

ERIC Educational Resources Information Center

Wiggins, Charles

2010-01-01

Enterprise Resource Planning (ERP) systems have greatly enhanced the efficiency and continuity of the business process and the flow of information technology in order to support organizations. ERP was intended to be used as a tool for manufacturing in an effort to build a more cohesive customer relationship. Lately many "Fortune" 500 companies…