Recycling and Reuse of Radioactive Materials

ERIC Educational Resources Information Center

O'Dou, Thomas Joseph

2012-01-01

The Radiochemistry Program at the University of Nevada, Las Vegas (UNLV) has a Radiation Protection Program that was designed to provide students with the ability to safely work with radioactive materials in quantities that are not available in other academic environments. Requirements for continuous training and supervision make this unique…

Technetium Tetrachloride Revisited: A Precursor to Lower-Valent Binary Technetium Chlorides

DOE PAGES

Johnstone, Erik V.; Poineau, Frederic; Forster, Paul M.; ...

2012-07-09

Technetium (Tc) is the lightest element that doesn't occur in nature. At UNLV, our radiochemistry program gives us access to Tc and the ability to make various Tc compounds. Here we describe the preparation and characterization of TcCl 4. The Tc atom is found to have a magnetic moment and magnetically orders at low temperature. As discerning trends in the transition metals, of which Tc is one, is important for understanding all transition metal compounds, this research is relevant to understanding these materials.

Start, Stop, Restart: The Recent History of Federal Funding for Radiochemistry Education

NASA Astrophysics Data System (ADS)

Williamson, R. Craig

2009-08-01

Over the course of the 2009, Federal Fiscal Year the U.S. Departments of Homeland Security and Defense will introduce university programs designed to provide the U.S. national laboratories with a highly qualified workforce in nuclear forensics. These programs are designed to recruit the best and brightest students, develop universities research and education activities, and to enhance university/laboratory(s) interactions nuclear forensics. The approach will be comprehensive in that it will target undergraduate and graduate students, faculty members and institutions. This will include an undergraduate research program designed to encourage emerging seniors to perform research at designated national laboratories throughout the United States. In addition to the undergraduate program, a nationally competitive graduate fellowship program in nuclear forensics was established in 2008. This program provides a four-year appointment with a monthly stipend, full payment of tuition and fees, the establishment of participating universities, and required post-graduate positions in nuclear forensics. A Nuclear Forensics Education Award program will also be introduced. This broad-based program will have an impact on university programs interested in developing nuclear forensics capabilities. This will include funds for instrumentation and equipment, faculty members, students, and curriculum.

Microfluidic technology platforms for synthesizing, labeling and measuring the kinetics of transport and biochemical reactions for developing molecular imaging probes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phelps, Michael E.

2009-09-01

Radiotracer techniques are used in environmental sciences, geology, biology and medicine. Radiotracers with Positron Emission Tomography (PET) provided biological examinations of ~3 million patients 2008. Despite the success of positron labeled tracers in many sciences, there is limited access in an affordable and convenient manner to develop and use new tracers. Integrated microfluidic chips are a new technology well matched to the concentrations of tracers. Our goal is to develop microfluidic chips and new synthesis approaches to enable wide dissemination of diverse types of tracers at low cost, and to produce new generations of radiochemists for which there are manymore » unfilled jobs. The program objectives are to: 1. Develop an integrated microfluidic platform technology for synthesizing and 18F-labeling diverse arrays of different classes of molecules. 2. Incorporate microfluidic chips into small PC controlled devices (“Synthesizer”) with a platform interfaced to PC for electronic and fluid input/out control. 3. Establish a de-centralized model with Synthesizers for discovering and producing molecular imaging probes, only requiring delivery of inexpensive [18F]fluoride ion from commercial PET radiopharmacies vs the centralized approach of cyclotron facilities synthesizing and shipping a few different types of 18F-probes. 4. Develop a position sensitive avalanche photo diode (PSAPD) camera for beta particles embedded in a microfluidic chip for imaging and measuring transport and biochemical reaction rates to valid new 18F-labeled probes in an array of cell cultures. These objectives are met within a research and educational program integrating radio-chemistry, synthetic chemistry, biochemistry, engineering and biology in the Crump Institute for Molecular Imaging. The Radiochemistry Training Program exposes PhD and post doctoral students to molecular imaging in vitro in cells and microorganisms in microfluidic chips and in vivo with PET, from new technologies for radiochemistry (macro to micro levels), biochemistry and biology to imaging principles, tracer kinetics, pharmacokinetics and biochemical assays. New generations of radiochemists will be immersed in the biochemistry and biology for which their labeled probes are being developed for assays of these processes. In this program engineers and radio-chemists integrate the principles of microfluidics and radiolabeling along with proper system design and chemistry rule sets to yield Synthesizers enabling biological and pharmaceutical scientists to develop diverse arrays of probes to pursue their interests. This progression would allow also radiochemists to focus on the further evolution of rapid, high yield synthetic reactions with new enabling technologies, rather than everyday production of radiotracers that should be done by technologists. The invention of integrated circuits in electronics established a platform technology that allowed an evolution of ideas and applications far beyond what could have been imagined at the beginning. Rather than provide a technology for the solution to a single problem, it is hoped that microfluidic radiochemistry will be an enabling platform technology for others to solve many problems. As part of this objective, another program goal is to commercialize the technologies that come from this work so that they can be provided to others who wish to use it.« less

U.S. Department of Energy Isotope Program

ScienceCinema

None

2018-01-16

The National Isotope Development Center (NIDC) interfaces with the User Community and manages the coordination of isotope production across the facilities and business operations involved in the production, sale, and distribution of isotopes. A virtual center, the NIDC is funded by the Isotope Development and Production for Research and Applications (IDPRA) subprogram of the Office of Nuclear Physics in the U.S. Department of Energy Office of Science. PNNL’s Isotope Program operates in a multi-program category-2 nuclear facility, the Radiochemical Processing Laboratory (RPL), that contains 16 hot cells and 20 gloveboxes. As part of the DOE Isotope Program, the Pacific Northwest National Laboratory dispenses strontium-90, neptunium-237, radium-223, and thorium-227. PNNL’s Isotope Program uses a dedicated hot-cell for strontium-90 dispensing and a dedicated glovebox for radium-223 and thorium-227 dispensing. PNNL’s Isotope Program has access to state of the art analytical equipment in the RPL to support their research and production activities. DOE Isotope Program funded research at PNNL has advanced the application of automated radiochemistry for isotope such as zirconium-89 and astatine-211 in partnership with the University of Washington.

U.S. Department of Energy Isotope Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The National Isotope Development Center (NIDC) interfaces with the User Community and manages the coordination of isotope production across the facilities and business operations involved in the production, sale, and distribution of isotopes. A virtual center, the NIDC is funded by the Isotope Development and Production for Research and Applications (IDPRA) subprogram of the Office of Nuclear Physics in the U.S. Department of Energy Office of Science. PNNL’s Isotope Program operates in a multi-program category-2 nuclear facility, the Radiochemical Processing Laboratory (RPL), that contains 16 hot cells and 20 gloveboxes. As part of the DOE Isotope Program, the Pacific Northwestmore » National Laboratory dispenses strontium-90, neptunium-237, radium-223, and thorium-227. PNNL’s Isotope Program uses a dedicated hot-cell for strontium-90 dispensing and a dedicated glovebox for radium-223 and thorium-227 dispensing. PNNL’s Isotope Program has access to state of the art analytical equipment in the RPL to support their research and production activities. DOE Isotope Program funded research at PNNL has advanced the application of automated radiochemistry for isotope such as zirconium-89 and astatine-211 in partnership with the University of Washington.« less

Applications of inductively coupled plasma-mass spectrometry in environmental radiochemistry

USGS Publications Warehouse

Grain, J.S.

1996-01-01

The state of the art in ICP-MS is now such that there are few discernible differences between radiochemical and mass spectrometric determinations of longlived radionuclides. Indeed, ICP-MS may provide better (more sensitive) data for many radionuclides, depending upon how one wishes to define "long-lived." In lowlevel determinations, sample preparation remains an important part of the analytical procedure, even with ICP-MS, but the speed and isotopic selectivity of the mass spectrometer appear to offer distinct procedural advantages over radiochemical techniques. Therefore, "radioanalytical" ICP-MS applications should continue to grow, especially in the area of radiation protection, but further research (on efficient sample introduction, for example) and method development may be required to get ICP-MS "off the ground" in the geochemical research areas that have traditionally been supported by radiochemistry.

New Mexico Center for Isotopes in Medicine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burchiel, Scott W.

2012-12-13

The purpose of the New Mexico Center for Isotopes in Medicine (NMCIM) is to support research, education and service missions of the UNM College of Pharmacy Radiopharmaceutical Sciences Program (COP RSP) and the Cancer Research and Treatment Center (CRTC). NMCIM developed and coordinated unique translational research in cancer radioimaging and radiotherapy agents based on novel molecules developed at UNM and elsewhere. NMCIM was the primary interface for novel radioisotopes and radiochemistries developed at the Los Alamos National Laboratory (LANL) for SPECT/PET imaging and therapy. NMCIM coordinated the use of the small animal imaging facility with the CRTC provided support servicesmore » to assist investigators in their studies. NMCIM developed education and training programs that benefited professional, graduate, and postdoctoral students that utilized its unique facilities and technologies. UNM COP RSP has been active in writing research and training grants, as well as supporting contract research with industrial partners. The ultimate goal of NMCIM is to bring new radiopharmaceutical imaging and therapeutic agents into clinical trials that will benefit the health and well being of cancer and other patients in New Mexico and the U.S.« less

Final Progress Report for Award DE-FG07-05ID14637.pdf

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cathy Dixon

2012-03-09

2004-2011 Final Report for AFCI University Fellowship Program. The goal of this effort was to be supportive of university students and university programs - particularly those students and programs that will help to strengthen the development of nuclear-related fields. The program also supported the stability of the nuclear infrastructure and developed research partnerships that are helping to enlarge the national nuclear science technology base. In this fellowship program, the U.S. Department of Energy sought master's degree students in nuclear, mechanical, or chemical engineering, engineering/applied physics, physics, chemistry, radiochemistry, or fields of science and engineering applicable to the AFCI/Gen IV/GNEP missionsmore » in order to meet future U.S. nuclear program needs. The fellowship program identified candidates and selected full time students of high-caliber who were taking nuclear courses as part of their degree programs. The DOE Academic Program Managers encouraged fellows to pursue summer internships at national laboratories and supported the students with appropriate information so that both the fellows and the nation's nuclear energy objectives were successful.« less

Support for Students, Postdoctoral Fellows and Trainees to Attend Radiochemistry-­Related Symposia at Pacifichem 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilbur, Daniel Scott

This project was undertaken to meet the growing need for training personnel who will be involved in professional careers requiring knowledge of radiochemistry, such as those working in radionuclide production, and in biological, industrial, medical and environmental fields that use radionuclides in their work. The goal of the project was to provide financial assistance to students and trainees from academic and government institutions (US preferred) to attend selected radiochemistry-­related symposia at the Pacifichem 2015 meeting held in Honolulu, Hawaii in December 2015. The funding, meant to provide a portion of an awardee’s travel cost, was specifically directed at attendance tomore » the following symposia: #363, Isotope production-­ Providing Important Materials for Research and Applications; #215, Chemistry of Molecular Imaging, and #11, Chemistry for Development of Theranostic Radiopharmaceuticals. Those symposia were held December 16th (am & pm: #11, #363), December 17th (am: #11, #363; pm: #275) and December 18th (am & pm: #275). Pacifichem meetings are held every 5 years in Honolulu, Hawaii. The meetings are joint sponsored by a number of Chemistry Societies from Pacific Rim countries. The meetings are composed of a large number of symposia (>300) on a wide variety of topics, which make them similar to small meetings within the larger overall meeting. Therefore, attendance at the three symposia within Pacifichem 2015 was similar to attending a meeting focused entirely on radiochemistry-­related topics. To obtain the financial assistance, the student/trainee: (a) had to be an undergraduate student, graduate student or Postdoctoral Fellow in a physical science department or National Laboratory; (b) had to submit a letter from their supervisor indicating that he/she will be enrolled as a student/trainee at the time of the meeting, and were committed to attending the meeting; and (c) had to submit a resume or curriculum vitae along with a brief statement of why they wanted to attend the symposia. The Bursary Selection Committee reviewed the applications and selected awardees from the students that applied. Attendance of the students/trainees to the Pacifichem 2015 symposia provided information on the role radiochemistry and radionuclides can have in the development of future diagnostic and therapeutic agents. It is very likely that attending the symposia stimulated student interest in radiochemistry, and thus, will provide support for their decision to enter the field, or an impetus to make this technical area a career choice. This stimulus will ultimately help to fill the future workforce needs for professionals trained in radiochemistry needed within US, and in particular the Department of Energy.« less

Ethanolic carbon-11 chemistry: the introduction of green radiochemistry.

PubMed

Shao, Xia; Fawaz, Maria V; Jang, Keunsam; Scott, Peter J H

2014-07-01

The principles of green chemistry have been applied to a radiochemistry setting. Eleven carbon-11 labeled radiopharmaceuticals have been prepared using ethanol as the only organic solvent throughout the entire manufacturing process. The removal of all other organic solvents from the process simplifies production and quality control (QC) testing, moving our PET Center towards the first example of a green radiochemistry laboratory. All radiopharmaceutical doses prepared are suitable for clinical use. Copyright © 2014 Elsevier Ltd. All rights reserved.

ERA—European Radiochemists Association: Report on the activities of the Working Party for Nuclear and Radiochemistry of the Federation of European Chemical Societies

NASA Astrophysics Data System (ADS)

Kolar, Z. I.; Ware, A. R.

2003-01-01

The European Radiochemists Association started almost simultaneously with the appearance of the first issue of the Radiochemistry in Europe newsletter in August 1995. The objective of the European Radiochemists Association (ERA) is to extend and improve communication between radiochemists in Europe through a newsletter. Liaison persons within each country or group exchange details of their activities, set up a diary of relevant international events and exchange details of specialist equipment, facilities and technology. In the year 2000 the Federation of European Chemical Societies decided to form a working party on nuclear and radiochemistry. It is a formalisation of the European Radiochemists Association. Each chemical society is allowed to nominate a member to the Working Party on Nuclear and Radiochemistry. Currently we have 12 nominated members plus two invited and one observer. In addition to the ERA aims and objectives it proposes to put together a syllabus of radiochemistry for undergraduate and post-graduate students—this aspect has been a part of our support of the International Atomic Energy Agency initiative. Also the aim of the working party is to support other working parties and divisions, to press the Federation of the European Chemical Societies for financial structure. To this end an Expression of Interest has been tabled with the Framework 6 Programme for networking within radiochemistry in Europe. The WP will liaise with the International Isotope Society and the International Society on Radiopharmaceutical Chemistry and Biology to seek to communicate and to consider ways of working together.

UCLA Translational Biomarker Development Program (UTBD)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Czernin, Johannes

2014-09-01

The proposed UTBD program integrates the sciences of diagnostic nuclear medicine and (radio)chemistry with tumor biology and drug development. UTBD aims to translate new PET biomarkers for personalized medicine and to provide examples for the use of PET to determine pharmacokinetic (PK) and pharmacodynamic (PD) drug properties. The program builds on an existing partnership between the Ahmanson Translational Imaging Division (ATID) and the Crump Institute of Molecular Imaging (CIMI), the UCLA Department of Chemistry and the Division of Surgical Oncology. ATID provides the nuclear medicine training program, clinical and preclinical PET/CT scanners, biochemistry and biology labs for probe and drugmore » development, radiochemistry labs, and two cyclotrons. CIMI provides DOE and NIH-funded training programs for radio-synthesis (START) and molecular imaging (SOMI). Other participating entities at UCLA are the Department of Chemistry and Biochemistry and the Division of Surgical Oncology. The first UTBD project focuses on deoxycytidine kinase, a rate-limiting enzyme in nucleotide metabolism, which is expressed in many cancers. Deoxycytidine kinase (dCK) positive tumors can be targeted uniquely by two distinct therapies: 1) nucleoside analog prodrugs such as gemcitabine (GEM) are activated by dCK to cytotoxic antimetabolites; 2) recently developed small molecule dCK inhibitors kill tumor cells by starving them of nucleotides required for DNA replication and repair. Since dCK-specific PET probes are now available, PET imaging of tumor dCK activity could improve the use of two different classes of drugs in a wide variety of cancers.« less

Nuclear medicine and imaging research: Quantitative studies in radiopharmaceutical science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Copper, M.; Beck, R.N.

1991-06-01

During the past three years the program has undergone a substantial revitalization. There has been no significant change in the scientific direction of this grant, in which emphasis continues to be placed on developing new or improved methods of obtaining quantitative data from radiotracer imaging studies. However, considerable scientific progress has been made in the three areas of interest: Radiochemistry, Quantitative Methodologies, and Experimental Methods and Feasibility Studies, resulting in a sharper focus of perspective and improved integration of the overall scientific effort. Changes in Faculty and staff, including development of new collaborations, have contributed to this, as has acquisitionmore » of additional and new equipment and renovations and expansion of the core facilities. 121 refs., 30 figs., 2 tabs.« less

Nuclear and Radiochemistry: the First 100 Years

NASA Astrophysics Data System (ADS)

Friedlander, G.; Herrmann, G.

This chapter gives a brief overview of the development of nuclear and radiochemistry from Mme. Curie's chemical isolation of radium toward the end of the twentieth century. The first four sections deal with fairly distinct time periods: (1) the pioneering years when the only radioactive materials available were the naturally occurring ones; (2) the decade of rapid growth and expansion of both the fundamental science and its applications following the discoveries of the neutron and artificial radioactivity; (3) the World War II period characterized by the intense exploration of nuclear fission and its ramifications; (4) what can be called the “golden era” - the 3 to 4 decades following World War II when nuclear science was generously supported and therefore flourished. In the final section, research trends pursued near the end of the century are briefly touched upon.

Learning Nuclear Chemistry through Practice: A High School Student Project Using PET in a Clinical Setting

ERIC Educational Resources Information Center

Liguori, Lucia; Adamsen, Tom Christian Holm

2013-01-01

Practical experience is vital for promoting interest in science. Several aspects of chemistry are rarely taught in the secondary school curriculum, especially nuclear and radiochemistry. Therefore, we introduced radiochemistry to secondary school students through positron emission tomography (PET) associated with computer tomography (CT). PET-CT…

The automated radiosynthesis and purification of the opioid receptor antagonist, [6-O-methyl-11C]diprenorphine on the GE TRACERlab FXFE radiochemistry module.

PubMed

Fairclough, Michael; Prenant, Christian; Brown, Gavin; McMahon, Adam; Lowe, Jonathan; Jones, Anthony

2014-05-15

[6-O-Methyl-(11)C]diprenorphine ([(11)C]diprenorphine) is a positron emission tomography ligand used to probe the endogenous opioid system in vivo. Diprenorphine acts as an antagonist at all of the opioid receptor subtypes, that is, μ (mu), κ (kappa) and δ (delta). The radiosynthesis of [(11)C]diprenorphine using [(11)C]methyl iodide produced via the 'wet' method on a home-built automated radiosynthesis set-up has been described previously. Here, we describe a modified synthetic method to [(11)C]diprenorphine performed using [(11)C]methyl iodide produced via the gas phase method on a GE TRACERlab FXFE radiochemistry module. Also described is the use of [(11)C]methyl triflate as the carbon-11 methylating agent for the [(11)C]diprenorphine syntheses. [(11)C]Diprenorphine was produced to good manufacturing practice standards for use in a clinical setting. In comparison to previously reported [(11)C]diprenorphine radiosyntheisis, the method described herein gives a higher specific activity product which is advantageous for receptor occupancy studies. The radiochemical purity of [(11)C]diprenorphine is similar to what has been reported previously, although the radiochemical yield produced in the method described herein is reduced, an issue that is inherent in the gas phase radiosynthesis of [(11)C]methyl iodide. The yields of [(11)C]diprenorphine are nonetheless sufficient for clinical research applications. Other advantages of the method described herein are an improvement to both reproducibility and reliability of the production as well as simplification of the purification and formulation steps. We suggest that our automated radiochemistry route to [(11)C]diprenorphine should be the method of choice for routine [(11)C]diprenorphine productions for positron emission tomography studies, and the production process could easily be transferred to other radiochemistry modules such as the TRACERlab FX C pro. Copyright © 2014 John Wiley & Sons, Ltd.

Improving cancer treatment with cyclotron produced radionuclides. Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larson, S.M.; Finn, R.D.

1992-08-04

Our goal is to improve the scientific basis for tumor diagnosis, treatment and treatment follow-up based on the use of cyclotron produced radiotracers in oncology. The grant includes 3 interactive components: Radiochemistry/Cyclotron; Pharmacology; and Immunology. The radiochemistry group seeks to develop innovative cyclotron targetry, radiopharmaceuticals, and radiolabeled antibodies, which are then used to assess important unanswered questions in tumor pharmacology and immunology. Examples include selected positron emitting radionuclides, such as Iodine-124, and Ga-66; I-124, I-123, I-131 labeled iododeoxyuridine, C-11 colchicine, and antimetabolites, like C-11 methotrexate; and radiolabeled antibodies, 3F8, M195, A33, and MRK16 for application in the pharmacology and immunologymore » projects. The pharmacology program studies tumor resistance to chemotherapy, particularly the phenomenon of multidrug resistance and the relationship between tumor uptake and retention and the tumor response for anti-metabolite drugs. The immunology program studies the physiology of antibody localization at the tissue level as the basis for novel approaches to improving tumor localization such as through the use of an artificial lymphatic system which mechanically reduces intratumoral pressures in tumors in vivo. Quantitative imaging approaches based on PET and SPECT in radioimmunotherapy are studied to give greater insight into the physiology of tumor localization and dosimetry.« less

Improving cancer treatment with cyclotron produced radionuclides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larson, S.M.; Finn, R.D.

1992-08-04

Our goal is to improve the scientific basis for tumor diagnosis, treatment and treatment follow-up based on the use of cyclotron produced radiotracers in oncology. The grant includes 3 interactive components: Radiochemistry/Cyclotron; Pharmacology; and Immunology. The radiochemistry group seeks to develop innovative cyclotron targetry, radiopharmaceuticals, and radiolabeled antibodies, which are then used to assess important unanswered questions in tumor pharmacology and immunology. Examples include selected positron emitting radionuclides, such as Iodine-124, and Ga-66; I-124, I-123, I-131 labeled iododeoxyuridine, C-11 colchicine, and antimetabolites, like C-11 methotrexate; and radiolabeled antibodies, 3F8, M195, A33, and MRK16 for application in the pharmacology and immunologymore » projects. The pharmacology program studies tumor resistance to chemotherapy, particularly the phenomenon of multidrug resistance and the relationship between tumor uptake and retention and the tumor response for anti-metabolite drugs. The immunology program studies the physiology of antibody localization at the tissue level as the basis for novel approaches to improving tumor localization such as through the use of an artificial lymphatic system which mechanically reduces intratumoral pressures in tumors in vivo. Quantitative imaging approaches based on PET and SPECT in radioimmunotherapy are studied to give greater insight into the physiology of tumor localization and dosimetry.« less

Glenn T. Seaborg and heavy ion nuclear science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loveland, W.

1992-04-01

Radiochemistry has played a limited but important role in the study of nucleus-nucleus collisions. Many of the important radiochemical studies have taken place in Seaborg's laboratory or in the laboratories of others who have spent time in Berkeley working with Glenn T. Seaborg. I will discuss studies of low energy deep inelastic reactions with special emphasis on charge equilibration, studies of the properties of heavy residues in intermediate energy nuclear collisions and studies of target fragmentation in relativistic and ultrarelativistic reactions. The emphasis will be on the unique information afforded by radiochemistry and the physical insight derived from radiochemical studies.more » Future roles of radiochemistry in heavy ion nuclear science also will be discussed.« less

Glenn T. Seaborg and heavy ion nuclear science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loveland, W.

1992-04-01

Radiochemistry has played a limited but important role in the study of nucleus-nucleus collisions. Many of the important radiochemical studies have taken place in Seaborg`s laboratory or in the laboratories of others who have spent time in Berkeley working with Glenn T. Seaborg. I will discuss studies of low energy deep inelastic reactions with special emphasis on charge equilibration, studies of the properties of heavy residues in intermediate energy nuclear collisions and studies of target fragmentation in relativistic and ultrarelativistic reactions. The emphasis will be on the unique information afforded by radiochemistry and the physical insight derived from radiochemical studies.more » Future roles of radiochemistry in heavy ion nuclear science also will be discussed.« less

The Texas A&M Radioisotope Production and Radiochemistry Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akabani, Gamal

The main motivation of the project at Texas A&M University was to carry out the production of critically needed radioisotopes used in medicine for diagnostic and therapy, and to establish an academic program in radionuclide production and separation methods. After a lengthy battle with the Texas A&M University Radiation Safety Office, the Texas Department of State Health Services granted us a license for the production of radionuclides in July 2015, allowing us to work in earnest in our project objectives. Experiments began immediately after licensing, and we started the assembly and testing of our target systems. There were four analytical/theoreticalmore » projects and two experimental target systems. These were for At-211 production and for Zn- 62/Cu-62 production. The theoretical projects were related to the production of Mo-99/Tc-99m using (a) a subcritical aqueous target system and (b) production of Tc-99m from accelerator-generated Mo-99 utilizing a photon-neutron interaction with enriched Mo-100 targets. The two experimental projects were the development of targetry systems and production of At-211 and Zn-62/Cu-62 generator. The targetry system for At-211 has been tested and production of At-211 is chronic depending of availability of beam time at the cyclotron. The installation and testing of the targetry system for the production of Zn-62/Cu-62 has not been finalized. A description of the systems is described. The academic program in radionuclide production and separation methods was initiated in the fall of 2011; due to the lack of a radiochemistry laboratory, it was suspended. We expect to re-start the academic program at the Texas A&M Institute for Preclinical Studies under the Molecular Imaging Program.« less

The Texas A&M Radioisotope Production and Radiochemistry Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akabani, Gamal

The main motivation of the project at Texas A&M University was to carry out the production of critically needed radioisotopes used in medicine for diagnostics and therapy, and to establish an academic program in radionuclide production and separation methods. After a lengthy battle with the Texas A&M University Radiation Safety Office, the Texas Department of State Health Services granted us a license for the production of radionuclides in July 2015, allowing us to work in earnest in our project objectives. Experiments began immediately after licensing, and we started the assembly and testing of our target systems. There were four analytical/theoreticalmore » projects and two experimental target systems. These were for At-211 production and for Zn-62/Cu-62 production. The theoretical projects were related to the production of Mo-99/Tc-99m using a) a subcritical aqueous target system and b) production of Tc-99m from accelerator-generated Mo-99 utilizing a photon-neutron interaction with enriched Mo-100 targets. The two experimental projects were the development of targetry systems and production of At-211 and Zn-62/Cu-62 generator. The targetry system for At-211 has been tested and production of At-211 is chronic depending of availability of beam time at the cyclotron. The installation and testing of the targetry system for the production of Zn-62/Cu-62 has not been finalized. A description of the systems is described. The academic program in radionuclide production and separation methods was initiated in the fall of 2011 and, due to the lack of a radiochemistry laboratory, it was suspended. We expect to re-start the academic program at the Texas A&M Institute for Preclinical Studies under the Molecular Imaging Program.« less

Radiosyntheses using Fluorine-18: the Art and Science of Late Stage Fluorination

PubMed Central

Cole, Erin L.; Stewart, Megan N.; Littich, Ryan; Hoareau, Raphael; Scott, Peter J. H.

2014-01-01

Positron (β+) emission tomography (PE) is a powerful, noninvasive tool for the in vivo, three-dimensional imaging of physiological structures and biochemical pathways. The continued growth of PET imaging relies on a corresponding increase in access to radiopharmaceuticals (biologically active molecules labeled with short-lived radionuclides such as fluorine-18). This unique need to incorporate the short-lived fluorine-18 atom (t1/2 = 109.77 min) as late in the synthetic pathway as possible has made development of methodologies that enable rapid and efficient late stage fluorination an area of research within its own right. In this review we describe strategies for radiolabeling with fluorine-18, including classical fluorine-18 radiochemistry and emerging techniques for late stage fluorination reactions, as well as labeling technologies such as microfluidics and solid-phase radiochemistry. The utility of fluorine-18 labeled radiopharmaceuticals is showcased through recent applications of PET imaging in the healthcare, personalized medicine and drug discovery settings. PMID:24484425

Development of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mossine, Andrew V.; Brooks, Allen F.; Ichiishi, Naoko

In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to radiopharmaceuticals that were challenging to synthesize using traditional fluorine-18 radiochemistry. However, the process of adapting these new reactions for automated radiopharmaceutical production has revealed limitations in fitting them into the confines of traditional radiochemistry systems. In particular, the presence of bases (e.g. K 2CO 3) and/or phase transfer catalysts (PTC) (e.g. kryptofix 2.2.2) associated with fluorine-18 preparation has been found to be detrimental to reaction yields. We hypothesizedmore » that these limitations could be addressed through the development of alternate techniques for preparing [18F]fluoride. This approach also opens the possibility that an eluent can be individually tailored to meet the specific needs of a metal-catalyzed reaction of interest. In this communication, we demonstrate that various solutions of copper salts, bases, and ancillary ligands can be utilized to elute [ 18F]fluoride from ion exchange cartridges. The new procedures we present here are effective for fluorine-18 radiochemistry and, as proof of concept, have been used to optimize an otherwise base-sensitive copper-mediated radiofluorination reaction.« less

Development of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination

DOE PAGES

Mossine, Andrew V.; Brooks, Allen F.; Ichiishi, Naoko; ...

2017-03-22

In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to radiopharmaceuticals that were challenging to synthesize using traditional fluorine-18 radiochemistry. However, the process of adapting these new reactions for automated radiopharmaceutical production has revealed limitations in fitting them into the confines of traditional radiochemistry systems. In particular, the presence of bases (e.g. K 2CO 3) and/or phase transfer catalysts (PTC) (e.g. kryptofix 2.2.2) associated with fluorine-18 preparation has been found to be detrimental to reaction yields. We hypothesizedmore » that these limitations could be addressed through the development of alternate techniques for preparing [18F]fluoride. This approach also opens the possibility that an eluent can be individually tailored to meet the specific needs of a metal-catalyzed reaction of interest. In this communication, we demonstrate that various solutions of copper salts, bases, and ancillary ligands can be utilized to elute [ 18F]fluoride from ion exchange cartridges. The new procedures we present here are effective for fluorine-18 radiochemistry and, as proof of concept, have been used to optimize an otherwise base-sensitive copper-mediated radiofluorination reaction.« less

Click Chemistry and Radiochemistry: The First 10 Years.

PubMed

Meyer, Jan-Philip; Adumeau, Pierre; Lewis, Jason S; Zeglis, Brian M

2016-12-21

The advent of click chemistry has had a profound influence on almost all branches of chemical science. This is particularly true of radiochemistry and the synthesis of agents for positron emission tomography (PET), single photon emission computed tomography (SPECT), and targeted radiotherapy. The selectivity, ease, rapidity, and modularity of click ligations make them nearly ideally suited for the construction of radiotracers, a process that often involves working with biomolecules in aqueous conditions with inexorably decaying radioisotopes. In the following pages, our goal is to provide a broad overview of the first 10 years of research at the intersection of click chemistry and radiochemistry. The discussion will focus on four areas that we believe underscore the critical advantages provided by click chemistry: (i) the use of prosthetic groups for radiolabeling reactions, (ii) the creation of coordination scaffolds for radiometals, (iii) the site-specific radiolabeling of proteins and peptides, and (iv) the development of strategies for in vivo pretargeting. Particular emphasis will be placed on the four most prevalent click reactions-the Cu-catalyzed azide-alkyne cycloaddition (CuAAC), the strain-promoted azide-alkyne cycloaddition (SPAAC), the inverse electron demand Diels-Alder reaction (IEDDA), and the Staudinger ligation-although less well-known click ligations will be discussed as well. Ultimately, it is our hope that this review will not only serve to educate readers but will also act as a springboard, inspiring synthetic chemists and radiochemists alike to harness click chemistry in even more innovative and ambitious ways as we embark upon the second decade of this fruitful collaboration.

Correction to Account for the Isomer of 87Y in the 87Y Radiochemical Diagnostic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hayes-Sterbenz, Anna Catherine; Jungman, Gerard

Here we summarize the need to correct inventories of 87Y reported by the Los Alamos weapons radiochemistry team. The need for a correction arises from the fact that a 13.37 hour isomer of 87Y, that is strongly populated through (n, 2n) reactions on 88Y and isomers of 88Y, has not been included in the experimental analyses of NTS data. Inventories of 87Y reported by LANL’s weapons radiochemistry team should be multiplied by a correction factor that is numerically close to 0.9. Alternatively, the user could increase simulated values of 87Y by 1.1 for comparison with the original method for reportingmore » NTS values. If the inventories in question were directly reported by LLNL’s radiochemistry team, care must be taken to determine whether or not the correction factor has already been applied.« less

DHS National Technical Nuclear Forensics Program FY 10 Summary Report: Graduate Mentoring Assistance Program (GMAP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martha R. Finck Ph.D.

2011-10-01

This program provides practical training to DHS graduate fellows in the DOE laboratory complex. It involves coordinating students, their thesis advisors, and their laboratory project mentors in establishing a meaningful program of research which contributes to the graduate student's formation as a member of the nuclear forensics community. The summary report details the student/mentor experience and future plans after the first summer practicum. This program provides practical training to DHS graduate fellows in the DOE laboratory complex. It involves coordinating students, their thesis advisors, and their laboratory project mentors in establishing a meaningful program of research which contributes to themore » graduate student's formation as a member of the nuclear forensics community. This final written report includes information concerning the overall mentoring experience, including benefits (to the lab, the mentors, and the students), challenges, student research contributions, and lab mentor interactions with students home universities. Idaho National Laboratory hosted two DHS Nuclear Forensics graduate Fellows (nuclear engineering) in summer 2011. Two more Fellows (radiochemistry) are expected to conduct research at the INL under this program starting in 2012. An undergraduate Fellow (nuclear engineering) who worked in summer 2011 at the laboratory is keenly interested in applying for the NF Graduate Fellowship this winter with the aim of returning to INL. In summary, this program appears to have great potential for success in supporting graduate level students who pursue careers in nuclear forensics. This relatively specialized field may not have been an obvious choice for some who have already shown talent in the traditional areas of chemistry or nuclear engineering. The active recruiting for this scholarship program for candidates at universities across the U.S. brings needed visibility to this field. Not only does this program offer critical practical training to these students, it brings attention to a very attractive field of work where young professionals are urgently required in order for the future. The effectiveness of retaining such talent remains to be seen and may be primarily controlled by the availability of DOE laboratory research funding in this field in the years to come.« less

Nuclear Forensics and Radiochemistry: Fission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rundberg, Robert S.

Radiochemistry has been used to study fission since it’ discovery. Radiochemical methods are used to determine cumulative mass yields. These measurements have led to the two-mode fission hypothesis to model the neutron energy dependence of fission product yields. Fission product yields can be used for the nuclear forensics of nuclear explosions. The mass yield curve depends on both the fuel and the neutron spectrum of a device. Recent studies have shown that the nuclear structure of the compound nucleus can affect the mass yield distribution.

Recent advances and results from the solid radiochemistry nuclear diagnostic at the National Ignition Facility

DOE PAGES

Gharibyan, N.; Shaughnessy, D. A.; Moody, K. J.; ...

2016-08-05

The solid debris collection capability at the National Ignition Facility has been expanded to include a third line-of-sight assembly. The solid radiochemistry nuclear diagnostic measurement of the ratio of gold isotopes is dependent on the efficient collection of neutron-activated hohlraum debris by passive metal disks. As a result, the collection of target debris at this new location is more reliable in comparison to the historic locations, and it appears to be independent of collector surface ablation.

Fluorine-18 patents (2009–2015). Part 2: new radiochemistry

PubMed Central

Mossine, Andrew V; Thompson, Stephen; Brooks, Allen F; Sowa, Alexandra R; Miller, Jason M; Scott, Peter JH

2016-01-01

Fluorine-18 (18F) is one of the most common positron-emitting radionuclides used in the synthesis of positron emission tomography radiotracers due to its ready availability, convenient half-life and outstanding imaging properties. In Part 1 of this review, we presented the first analysis of patents issued for novel radiotracers labeled with fluorine-18. In Part 2, we follow-up with a focus on patents issued for new radiochemistry methodology using fluorine-18 issued between January 2009 and December 2015. PMID:27610753

Recent advances and results from the solid radiochemistry nuclear diagnostic at the National Ignition Facility.

PubMed

Gharibyan, N; Shaughnessy, D A; Moody, K J; Grant, P M; Despotopulos, J D; Faye, S A; Jedlovec, D R; Yeamans, C B

2016-11-01

The solid debris collection capability at the National Ignition Facility has been expanded to include a third line-of-sight assembly. The solid radiochemistry nuclear diagnostic measurement of the ratio of gold isotopes is dependent on the efficient collection of neutron-activated hohlraum debris by passive metal disks. The collection of target debris at this new location is more reliable in comparison to the historic locations, and it appears to be independent of collector surface ablation.

California Alliance For Radiotracer Education, CARE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutcliffe, Julie

The report contains a summary of the accomplishments made during the CARE proposal. The overall goal of this proposal was to train graduate students and postdoctoral fellows in the field of radiochemistry. The goal was to expose trainees to the fundamentals of radioisotope production, radiochemistry synthesis, synthetic organic chemistry as well as applications and hands on experience in small animal imaging. In summary approximately 30 trainees were involved including trainees both at the graduate and postdoctoral levels. This funding has to date resulted in publications in high impact journals such as Med Chem Comm, Journal of Nuclear Medicine and Molecularmore » Imaging and Biology. Trainees have gone on to further their careers in both academia, industry and the private sector. The funding will result in seven Master’s and six Ph.D dissertations. Without the DOE funding it simply would not have been possible to continue to train the next generation of radiochemists needed to assure a future US-based Nuclear and Radiochemistry Expertise.« less

User`s and reference guide to the INEL RML/analytical radiochemistry sample tracking database version 1.00

DOE Office of Scientific and Technical Information (OSTI.GOV)

Femec, D.A.

This report discusses the sample tracking database in use at the Idaho National Engineering Laboratory (INEL) by the Radiation Measurements Laboratory (RML) and Analytical Radiochemistry. The database was designed in-house to meet the specific needs of the RML and Analytical Radiochemistry. The report consists of two parts, a user`s guide and a reference guide. The user`s guide presents some of the fundamentals needed by anyone who will be using the database via its user interface. The reference guide describes the design of both the database and the user interface. Briefly mentioned in the reference guide are the code-generating tools, CREATE-SCHEMAmore » and BUILD-SCREEN, written to automatically generate code for the database and its user interface. The appendices contain the input files used by the these tools to create code for the sample tracking database. The output files generated by these tools are also included in the appendices.« less

Radiochemistry Research: Progress Report, October 1, 1974 to September 30, 1975

DOE R&D Accomplishments Database

Rowland, F. S.

1975-01-01

A major effort has been made this year to pursue details of the effects of the chlorofluoromethanes in the environment. The AEC report written in September, 1974, was revised and published as a review article in Reviews of Geophysics and Space Physics. A shorter description was published in the New Scientist in December, 1974. Three additional papers were published on the stratospheric chlorine problem. Testimony was provided at various hearings.

Nuclear Forensics and Radiochemistry: Chemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rundberg, Robert S.

The chemical behavior of radioactive elements can differ from conventional wisdom because the number of atoms can be unusually small. Kinetic effects and unusual oxidation states are phenomena that make radiochemistry different from conventional analytic chemistry. The procedures developed at Los Alamos are designed to minimize these effects and provide reproducible results over a wide range of sample types. The analysis of nuclear debris has the additional complication of chemical fractionation and the incorporation of environmental contaminants. These are dealt with through the use of three component isotope ratios and the use of appropriate end members.

Large Area Solid Radiochemistry (LASR) collector at the National Ignition Facility

NASA Astrophysics Data System (ADS)

Waltz, Cory; Gharibyan, Narek; Hardy, Mike; Shaughnessy, Dawn; Jedlovec, Don; Smith, Cal

2017-08-01

The flux of neutrons and charged particles produced from inertial confinement fusion experiments at the National Ignition Facility (NIF) induces measurable concentrations of nuclear reaction products in various target materials. The collection and radiochemical analysis of the post-shot debris can be utilized as an implosion diagnostic to obtain information regarding fuel areal density and ablator-fuel mixing. Furthermore, assessment of the debris from specially designed targets, material doped in capsules or mounted on the external surface of the target assembly, can support experiments relevant to nuclear forensic research. To collect the shot debris, we have deployed the Large Area Solid Radiochemistry Collector (LASR) at NIF. LASR uses a main collector plate that contains a large collection foil with an exposed 20 cm diameter surface located ˜50 cm from the NIF target. This covers ˜0.12 steradians, or about 1% of the total solid angle. We will describe the design, analysis, and operation of this experimental platform as well as the initial results. To speed up the design process 3-dimensional printing was utilized. Design analysis includes the dynamic loading of the NIF target vaporized mass, which was modeled using LS-DYNA.

Radiochemistry in the twenty-first century: Strenghts, weaknesses, opportunities and threats

NASA Astrophysics Data System (ADS)

de Goeij, J. J. M.

2003-01-01

Strengths, weaknesses, opportunities and threats of radiochemistry and associated nuclear chemistry are discussed. For that purpose radiochemistry is subdivided into three categories. The first category covers fundamental aspects, e.g. nuclear reaction cross-sections, production routes with associated yields and radionuclidic impurities, decay schemes, radiochemical separations, recoil and hot-atom chemistry, isotope effects and fractionation, and interaction of radiation with matter and detection. The second category covers topics where radioactivity is inextricably involved, e.g. the nuclear fuel cycle, very heavy elements and other actinides, primordial and cosmogenic radioactivity, and radionuclide techniques for dating. The third category involves radioactivity as essential part of a technique. On one hand radioactivity is used here as source of ionising radiation for food conservation, polymerisation of plastics, sterilisation, radiotherapy and pain palliation. On the other hand it is used to get information on systems and materials, via radiotracer methods and nuclear activation techniques. In particular the latter field is experiencing strong competition with other, non-nuclear methods. In this frame it is indicated what is required to achieve a situation where nuclear analytical techniques may successfully be exploited to the full extent of their potentials, particularly in providing valuable and sometimes unique information.

Preparation of high purity plutonium oxide for radiochemistry instrument calibration standards and working standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wong, A.S.; Stalnaker, N.D.

1997-04-01

Due to the lack of suitable high level National Institute of Standards and Technology (NIST) traceable plutonium solution standards from the NIST or commercial vendors, the CST-8 Radiochemistry team at Los Alamos National Laboratory (LANL) has prepared instrument calibration standards and working standards from a well-characterized plutonium oxide. All the aliquoting steps were performed gravimetrically. When a {sup 241}Am standardized solution obtained from a commercial vendor was compared to these calibration solutions, the results agreed to within 0.04% for the total alpha activity. The aliquots of the plutonium standard solutions and dilutions were sealed in glass ampules for long termmore » storage.« less

A simple thick target for production of 89Zr using an 11MeV cyclotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Link, Jeanne M.; Krohn, Kenneth A.; O'Hara, Matthew J.

2017-04-01

The growing interest but limited availability of 89Zr for PET led us to test targets for the 89(p,n) reaction. The goal was an easily constructed target for an 11 MeV Siements cyclotron. Yttrium foils were tested at different thicknesses, angles and currents. A 90 degree foil tolerated 41 microAmp without damage and produced ~800 MBq/hr, >20 mCi, an amount adequate for radiochemistry research and human doses in a widely available accelerator. This method should translate to higher energy cyclotrons.

Status of Simulations for the Cyclotron Laboratory at the Institute for Nuclear Research and Nuclear Energy

NASA Astrophysics Data System (ADS)

Asova, G.; Goutev, N.; Tonev, D.; Artinyan, A.

2018-05-01

The Institute for Nuclear Research and Nuclear Energy is preparing to operate a high-power cyclotron for production of radioisotopes for nuclear medicine, research in radiochemistry, radiobiology, nuclear physics, solid state physics. The cyclotron is a TR24 produced by ASCI, Canada, capable to deliver proton beams in the energy range of 15 to 24 MeV with current as high as 400 µA. Multiple extraction lines can be fed. The primary goal of the project is the production of PET and SPECT isotopes as 18F, 67,68Ga, 99mTc, etc. This contribution reports the status of the project. Design considerations for the cyclotron vault will be discussed for some of the target radioisotopes.

Establishment of an Undergraduate Research and Training Program in Radiochemistry at Florida Memorial University, a Historically Black College or University (HBCU)

NASA Astrophysics Data System (ADS)

Tamalis, Dimitri; Stiffin, Rose; Elliott, Michael; Huisso, Ayivi; Biegalski, Steven; Landsberger, Sheldon

2009-08-01

With the passing of the Energy Policy Act of 2005, the United States is experiencing for the first time in over two decades, what some refer to as the "Nuclear Renaissance". The US Nuclear Regulatory Commission (NRC) recognizes this surge in application submissions and is committed to reviewing these applications in a timely manner to support the country's growing energy demands. Notwithstanding these facts, it is understood that the nuclear industry requires appropriately trained and educated personnel to support the growing needs of the nuclear industry and the US NRC. Equally important is the need to educate the next generation of students in nuclear non-proliferation, nuclear forensics and various aspects of homeland security for the national laboratories and the Department of Defense. From mechanical engineers educated and experienced in materials, thermal/fluid dynamics, and component failure analysis, to physicists using advanced computing techniques to design the next generation of nuclear reactor fuel elements, the need for new engineers, scientists, and health physicist has never been greater.

Total Radiosynthesis: Thinking outside "the box".

PubMed

Liang, Steven H; Vasdev, Neil

2015-09-01

The logic of total synthesis transformed a stagnant state of medicinal and synthetic organic chemistry when there was a paucity of methods and reagents to synthesize drug molecules and/or natural products. Molecular imaging by positron emission tomography (PET) is now experiencing a renaissance in the way radiopharmaceuticals for molecular imaging are synthesized, however, a paradigm shift is desperately needed in the discovery pipeline to accelerate in vivo imaging studies. A significant challenge in radiochemistry is the limited choice of labeled reagents (or building blocks) available for the synthesis of novel radiopharmaceuticals with the most commonly used short-lived radionuclides carbon-11 ( 11 C; half-life ~20 minutes) and fluorine-18 ( 18 F; half-life ~2 hours). In fact, most drugs cannot be labeled with 11 C or 18 F due to a lack of efficient and diverse radiosynthetic methods. In general, routine radiopharmaceutical production relies on the incorporation of the isotope at the last or penultimate step of synthesis, ideally within one half-life of the radionuclide, to maximize radiochemical yields and specific activities thereby reducing losses due to radioactive decay. Reliance on radiochemistry conducted within the constraints of an automated synthesis unit ("box") has stifled the exploration of multi-step reactions with short-lived radionuclides. Radiopharmaceutical synthesis can be transformed by considering logic of total synthesis to develop novel approaches for 11 C- and 18 F-radiolabeling complex molecules via retrosynthetic analysis and multi-step reactions. As a result of such exploration, new methods, reagents and radiopharmaceuticals for in vivo imaging studies are discovered. A new avenue to develop radiotracers that were previously unattainable due to the lack of efficient radiosynthetic methods is necessary to work towards our ultimate, albeit impossible goal - the concept we term total radiosynthesis - to radiolabel virtually any molecule. As with the vast majority of drugs, most radiotracers also fail, therefore expeditious evaluation of tracers in preclinical models prior to optimization or derivatization of the lead molecules/drugs is necessary. Furthermore the exact position of the 11 C and 18 F radionuclide in tracers is often critical for metabolic considerations, and flexible methodologies to introduce the radiolabel are needed. Using the principles of total synthesis our laboratory and others have shown that multi-step radiochemical reactions are indeed suitable for preclinical and even clinical use. As the goal of total synthesis is to be concise, we have also simplified the syntheses of radiopharmaceuticals. We are presently developing new strategies via [ 11 C]CO 2 fixation which has enabled library radiosynthesis as well as labeling non-activated arenes using [ 18 F]fluoride via iodonium ylides. Both of which have proven to be suitable for human PET imaging. We concurrently utilize state-of-the-art automation technologies including microfluidic flow chemistry and rapid purification strategies for radiopharmaceutical production. In this account we highlight how total radiosynthesis has impacted our radiochemistry program, with prominent examples from others, focusing on its impact towards preclinical and clinical research studies.

Total Radiosynthesis: Thinking outside “the box”

PubMed Central

Liang, Steven H.; Vasdev, Neil

2016-01-01

The logic of total synthesis transformed a stagnant state of medicinal and synthetic organic chemistry when there was a paucity of methods and reagents to synthesize drug molecules and/or natural products. Molecular imaging by positron emission tomography (PET) is now experiencing a renaissance in the way radiopharmaceuticals for molecular imaging are synthesized, however, a paradigm shift is desperately needed in the discovery pipeline to accelerate in vivo imaging studies. A significant challenge in radiochemistry is the limited choice of labeled reagents (or building blocks) available for the synthesis of novel radiopharmaceuticals with the most commonly used short-lived radionuclides carbon-11 (11C; half-life ~20 minutes) and fluorine-18 (18F; half-life ~2 hours). In fact, most drugs cannot be labeled with 11C or 18F due to a lack of efficient and diverse radiosynthetic methods. In general, routine radiopharmaceutical production relies on the incorporation of the isotope at the last or penultimate step of synthesis, ideally within one half-life of the radionuclide, to maximize radiochemical yields and specific activities thereby reducing losses due to radioactive decay. Reliance on radiochemistry conducted within the constraints of an automated synthesis unit (“box”) has stifled the exploration of multi-step reactions with short-lived radionuclides. Radiopharmaceutical synthesis can be transformed by considering logic of total synthesis to develop novel approaches for 11C- and 18F-radiolabeling complex molecules via retrosynthetic analysis and multi-step reactions. As a result of such exploration, new methods, reagents and radiopharmaceuticals for in vivo imaging studies are discovered. A new avenue to develop radiotracers that were previously unattainable due to the lack of efficient radiosynthetic methods is necessary to work towards our ultimate, albeit impossible goal – the concept we term total radiosynthesis - to radiolabel virtually any molecule. As with the vast majority of drugs, most radiotracers also fail, therefore expeditious evaluation of tracers in preclinical models prior to optimization or derivatization of the lead molecules/drugs is necessary. Furthermore the exact position of the 11C and 18F radionuclide in tracers is often critical for metabolic considerations, and flexible methodologies to introduce the radiolabel are needed. Using the principles of total synthesis our laboratory and others have shown that multi-step radiochemical reactions are indeed suitable for preclinical and even clinical use. As the goal of total synthesis is to be concise, we have also simplified the syntheses of radiopharmaceuticals. We are presently developing new strategies via [11C]CO2 fixation which has enabled library radiosynthesis as well as labeling non-activated arenes using [18F]fluoride via iodonium ylides. Both of which have proven to be suitable for human PET imaging. We concurrently utilize state-of-the-art automation technologies including microfluidic flow chemistry and rapid purification strategies for radiopharmaceutical production. In this account we highlight how total radiosynthesis has impacted our radiochemistry program, with prominent examples from others, focusing on its impact towards preclinical and clinical research studies. PMID:27512156

Estimating Am-241 activity in the body: comparison of direct measurements and radiochemical analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynch, Timothy P.; Tolmachev, Sergei Y.; James, Anthony C.

2009-06-01

The assessment of dose and ultimately the health risk from intakes of radioactive materials begins with estimating the amount actually taken into the body. An accurate estimate provides the basis to best assess the distribution in the body, the resulting dose, and ultimately the health risk. This study continues the time-honored practice of evaluating the accuracy of results obtained using in vivo measurement methods and techniques. Results from the radiochemical analyses of the 241Am activity content of tissues and organs from four donors to the United States Transuranium and Uranium Registries were compared to the results from direct measurements ofmore » radioactive material in the body performed in vivo and post mortem. Two were whole body donations and two were partial body donations The skeleton was the organ with the highest deposition of 241Am activity in all four cases. The activities ranged from 30 Bq to 300 Bq. The skeletal estimates obtained from measurements over the forehead were within 20% of the radiochemistry results in three cases and differed by 78% in one case. The 241Am lung activity estimates ranged from 1 Bq to 30 Bq in the four cases. The results from the direct measurements were within 40% of the radiochemistry results in 3 cases and within a factor of 3 for the other case. The direct measurement estimates of liver activity ranged from 2 Bq to 60 Bq and were generally lower than the radiochemistry results. The results from this study suggest that the measurement methods and calibration techniques used at the In Vivo Radiobioassay and Research Facility to quantify the activity in the lungs, skeleton and liver are reasonable under the most challenging conditions where there is 241Am activity in multiple organs. These methods and techniques are comparable to those used at other Department of Energy sites. This suggests that the current in vivo methods and calibration techniques provide reasonable estimates of radioactive material in the body. Not unexpectedly, there can be significant uncertainty in the estimates especially when activity is also present in other organs.« less

A simple thick target for production of 89Zr using an 11 MeV cyclotron

PubMed Central

Link, Jeanne M.; Krohn, Kenneth A.; O’Hara, Matthew J.

2017-01-01

The growing interest but limited availability of 89Zr for PET led us to test targets for the 89Y(p,n) reaction. The goal was an easily constructed target for an 11 MeV Siemens cyclotron. Yttrium foils were tested at different thicknesses, angles and currents. A 90° foil tolerated 41 μA without damage and produced ~800 MBq/h, > 20 mCi, an amount adequate for radiochemistry research and human doses in a widely available accelerator. This method should translate to higher energy cyclotrons. PMID:28187357

National Center for Nuclear Security: The Nuclear Forensics Project (F2012)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klingensmith, A. L.

These presentation visuals introduce the National Center for Nuclear Security. Its chartered mission is to enhance the Nation’s verification and detection capabilities in support of nuclear arms control and nonproliferation through R&D activities at the NNSS. It has three focus areas: Treaty Verification Technologies, Nonproliferation Technologies, and Technical Nuclear Forensics. The objectives of nuclear forensics are to reduce uncertainty in the nuclear forensics process & improve the scientific defensibility of nuclear forensics conclusions when applied to nearsurface nuclear detonations. Research is in four key areas: Nuclear Physics, Debris collection and analysis, Prompt diagnostics, and Radiochemistry.

Quality Control Guidelines for SAM Radiochemical Methods

EPA Pesticide Factsheets

Learn more about quality control guidelines and recommendations for the analysis of samples using the radiochemistry methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

Sucrose as a dosimetric material for photon and heavy particle radiation: A review

NASA Astrophysics Data System (ADS)

Karakirova, Yordanka; Yordanov, Nicola D.

2015-05-01

The application of high-energy radiation in many areas of human activity and its harmful effects on human health makes necessary knowledge of the radiation chemistry of various materials upon exposure to high-energy radiation. Among these materials, saccharides (particularly sucrose) maintain the greatest advantage for potential radiochemistry applications. Until now, radiation chemistry studies have been conducted primarily with γ-ray irradiation; however, in the past few years there has been increased interest in the fields of radiotherapy and radiochemistry on substances irradiated with heavy particles. To this end, this review discusses the possibilities of employing sucrose as a radiation-sensitive material for the determination of absorbed doses of high-energy radiation both for emergency situations and for dosimeters used in standard applications.

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

PubMed Central

Nwe, Kido

2009-01-01

Summation This update summarizes the growing application of “click” chemistry in diverse areas such as bioconjugation, drug discovery, materials science, and radiochemistry. This update also discusses click chemistry reactions that proceed rapidly with high selectivity, specificity, and yield. Two important characteristics make click chemistry so attractive for assembling compounds, reagents, and biomolecules for preclinical and clinical applications. First, click reactions are bio-orthogonal; neither the reactants nor their product's functional groups interact with functionalized biomolecules. Second, the reactions proceed with ease under mild nontoxic conditions, such as at room temperature and, usually, in water. The copper-catalyzed Huisgen cycloaddition, azide-alkyne [3 + 2] dipolar cycloaddition, Staudinger ligation, and azide-phosphine ligation each possess these unique qualities. These reactions can be used to modify one cellular component while leaving others unharmed or untouched. Click chemistry has found increasing applications in all aspects of drug discovery in medicinal chemistry, such as for generating lead compounds through combinatorial methods. Bioconjugation via click chemistry is rigorously employed in proteomics and nucleic research. In radiochemistry, selective radiolabeling of biomolecules in cells and living organisms for imaging and therapy has been realized by this technology. Bifunctional chelating agents for several radionuclides useful for positron emission tomography and single-photon emission computed tomography imaging have also been prepared by using click chemistry. This review concludes that click chemistry is not the perfect conjugation and assembly technology for all applications, but provides a powerful, attractive alternative to conventional chemistry. This chemistry has proven itself to be superior in satisfying many criteria (e.g., biocompatibility, selectivity, yield, stereospecificity, and so forth); thus, one can expect it will consequently become a more routine strategy in the near future for a wide range of applications. PMID:19538051

Analytical and Radiochemistry for Nuclear Forensics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steiner, Robert Ernest; Dry, Donald E.; Kinman, William Scott

Information about nonproliferation nuclear forensics, activities in forensics at Los Alamos National Laboratory, radio analytical work at LANL, radiochemical characterization capabilities, bulk chemical and materials analysis capabilities, and future interests in forensics interactions.

Modular Approach to Instrumental Analysis.

ERIC Educational Resources Information Center

Deming, Richard L.; And Others

1982-01-01

To remedy certain deficiencies, an instrument analysis course was reorganized into six one-unit modules: optical spectroscopy, magnetic resonance, separations, electrochemistry, radiochemistry, and computers and interfacing. Selected aspects of the course are discussed. (SK)

Radiochemistry and the Study of Fission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rundberg, Robert S.

These are slides from a lecture given at UC Berkeley. Radiochemistry has been used to study fission since its discovery. Radiochemical methods are used to determine cumulative mass yields. These measurements have led to the two-mode fission hypothesis to model the neutron energy dependence of fission product yields. Fission product yields can be used for the nuclear forensics of nuclear explosions. The mass yield curve depends on both the fuel and the neutron spectrum of a device. Recent studies have shown that the nuclear structure of the compound nucleus can affect the mass yield distribution. The following topics are covered:more » In the beginning: the discovery of fission; forensics using fission products: what can be learned from fission products, definitions of R-values and Q-values, fission bases, K-factors and fission chambers, limitations; the neutron energy dependence of the mass yield distribution (the two mode fission hypothesis); the influence of nuclear structure on the mass yield distribution. In summary: Radiochemistry has been used to study fission since its discovery. Radiochemical measurement of fission product yields have provided the highest precision data for developing fission models and for nuclear forensics. The two-mode fission hypothesis provides a description of the neutron energy dependence of the mass yield curve. However, data is still rather sparse and more work is needed near second and third chance fission. Radiochemical measurements have provided evidence for the importance of nuclear states in the compound nucleus in predicting the mass yield curve in the resonance region.« less

Decontamination and decommissioning of the Mayaguez (Puerto Rico) facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackson, P.K.; Freemerman, R.L.

1989-11-01

On February 6, 1987 the US Department of Energy (DOE) awarded the final phase of the decontamination and decommissioning of the nuclear and reactor facilities at the Center for Energy and Environmental Research (CEER), in Mayaguez, Puerto Rico. Bechtel National, Inc., was made the decontamination and decommissioning (D and D) contractor. The goal of the project was to enable DOE to proceed with release of the CEER facility for use by the University of Puerto Rico, who was the operator. This presentation describes that project and lesson learned during its progress. The CEER facility was established in 1957 as themore » Puerto Rico Nuclear Center, a part of the Atoms for Peace Program. It was a nuclear training and research institution with emphasis on the needs of Latin America. It originally consisted of a 1-megawatt Materials Testing Reactor (MTR), support facilities and research laboratories. After eleven years of operation the MTR was shutdown and defueled. A 2-megawatt TRIGA reactor was installed in 1972 and operated until 1976, when it woo was shutdown. Other radioactive facilities at the center included a 10-watt homogeneous L-77 training reactor, a natural uranium graphite-moderated subcritical assembly, a 200KV particle accelerator, and a 15,000 Ci Co-60 irradiation facility. Support facilities included radiochemistry laboratories, counting rooms and two hot cells. As the emphasis shifted to non-nuclear energy technology a name change resulted in the CEER designation, and plans were started for the decontamination and decommissioning effort.« less

Radioactive Dating: A Method for Geochronology.

ERIC Educational Resources Information Center

Rowe, M. W.

1985-01-01

Gives historical background on the discovery of natural radiation and discusses various techniques for using knowledge of radiochemistry in geochronological studies. Indicates that of these radioactive techniques, Potassium-40/Argon-40 dating is used most often. (JN)

Digital microfluidic platform for radiochemistry

DOEpatents

Van Dam, Michael R.; Kim, Chang-Jin; Chen, Supin; Ding, Huijiang; Shah, Gaurav Jitendra; Keng, Pei Yuin

2016-11-01

Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing .sup.18F.

Digital microfluidic platform for radiochemistry

DOEpatents

Van Dam, R. Michael; Kim, Chang -Jin; Chen, Supin; Ding, Huijiang; Shah, Gaurav Jitendra; Keng, Pei Yuin

2015-11-24

Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing .sup.18F.

Experiments in Radiochemistry: Paper Electrophorectic Separation of Superscript 90 Sr and Superscript 90 Y.

ERIC Educational Resources Information Center

Miekely, N.; Roldao, L. A.

1982-01-01

Using different supporting electrolytes, the influence of complex-forming equilibria on migration velocities of strontium-90 and yttrium-90 can be demonstrated in this experiment. Includes procedures and materials needed. (SK)

Digital microfluidics – a new paradigm for radiochemistry

PubMed Central

Keng, Pei Yuin; van Dam, R. Michael

2016-01-01

The emerging technology of digital microfluidics is opening up the possibility to perform radiochemistry at the microliter scale to produce tracers for positron emission tomography (PET) labeled with fluorine-18 or other isotopes. Working at this volume scale not only reduces reagent costs, but also improves specific activity (SA) by reduction of contamination by the stable isotope. This technology could provide a practical means to routinely prepare high SA tracers for applications such as neuroimaging, and could make it possible to routinely achieve high SA using synthesis strategies such as isotopic exchange. Reagent droplets are controlled electronically, providing high reliability, a compact control system, and flexibility for diverse syntheses with a single chip design. The compact size may enable the development of a self-shielded synthesizer that does not require a hot cell. This article reviews the progress of this technology and its application to the synthesis of PET tracers. PMID:26650206

A systematic investigation of PET Radionuclide Specific Activity on Miniaturization of Radiochemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeanne M Link, PhD

2012-03-08

The PET radionuclides, 18F and 11C consist of very high radiation to mass amounts and should be easily adapted to new technologies such as chip chemistry with nanofluidics. However, environmental contamination with nonradioactive fluorine, carbon and other trace contaminants add sufficient mass, micrograms to milligrams, to prevent adapting PET radiochemistry to the nanochip technologies. In addition, the large volumes of material required for beam irradiation make it necessary to also remove the 18F and 11C from their chemical matrices. These steps add contaminants. The work described in this report was a systematic investigation of sources of these contaminants and methodsmore » to reduce these contaminants and the reaction volumes for radiochemical synthesis. Several methods were found to lower the contaminants and matrices to within a factor of 2 to 100 of those needed to fully implement chip technology but further improvements are needed.« less

Nuclear Forensics and Radiochemistry: Radiation Detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rundberg, Robert S.

Radiation detection is necessary for isotope identification and assay in nuclear forensic applications. The principles of operation of gas proportional counters, scintillation counters, germanium and silicon semiconductor counters will be presented. Methods for calibration and potential pitfalls in isotope quantification will be described.

10 CFR Appendix A to Part 725 - Categories of Restricted Data Available

Code of Federal Regulations, 2013 CFR

2013-01-01

... and radiation studies. b. Chemistry, chemical engineering and radiochemistry of all the elements and their compounds. Included are techniques and processes of chemical separations, radioactive waste..., including chemical engineering, processes and techniques. Reactor physics, engineering and criticality...

The Experimental Determination of Thermal Neutron Flux in the Radiochemistry Curriculum

ERIC Educational Resources Information Center

Grant, Patrick M.

1977-01-01

Describes an experiment for determining the thermal neutron flux of the light-water nuclear reactor at the University of California, Irvine. The difficulty of the activity can be varied to match the student's level of proficiency. (SL)

Ray Next-Event Estimator Transport of Primary and Secondary Gamma Rays

DTIC Science & Technology

2011-03-01

McGraw-Hill. Choppin, G. R., Liljenzin, J.-O., & Rydberg, J. (2002). Radiochemistry and Nuclear Chemistry (3rd ed.). Woburn, MA: Butterworth- Heinemann ...time-energy bins. Any performance enhancements (maybe parallel searching?) to the search routines decrease estimator computational time

Laboratory Directed Research and Development FY2011 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, W; Sketchley, J; Kotta, P

2012-03-22

A premier applied-science laboratory, Lawrence Livermore National Laboratory (LLNL) has earned the reputation as a leader in providing science and technology solutions to the most pressing national and global security problems. The LDRD Program, established by Congress at all DOE national laboratories in 1991, is LLNL's most important single resource for fostering excellent science and technology for today's needs and tomorrow's challenges. The LDRD internally directed research and development funding at LLNL enables high-risk, potentially high-payoff projects at the forefront of science and technology. The LDRD Program at Livermore serves to: (1) Support the Laboratory's missions, strategic plan, and foundationalmore » science; (2) Maintain the Laboratory's science and technology vitality; (3) Promote recruiting and retention; (4) Pursue collaborations; (5) Generate intellectual property; and (6) Strengthen the U.S. economy. Myriad LDRD projects over the years have made important contributions to every facet of the Laboratory's mission and strategic plan, including its commitment to nuclear, global, and energy and environmental security, as well as cutting-edge science and technology and engineering in high-energy-density matter, high-performance computing and simulation, materials and chemistry at the extremes, information systems, measurements and experimental science, and energy manipulation. A summary of each project was submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to DOE/NNSA and LLNL mission areas, the technical progress achieved in FY11, and a list of publications that resulted from the research. The projects are: (1) Nuclear Threat Reduction; (2) Biosecurity; (3) High-Performance Computing and Simulation; (4) Intelligence; (5) Cybersecurity; (6) Energy Security; (7) Carbon Capture; (8) Material Properties, Theory, and Design; (9) Radiochemistry; (10) High-Energy-Density Science; (11) Laser Inertial-Fusion Energy; (12) Advanced Laser Optical Systems and Applications; (12) Space Security; (13) Stockpile Stewardship Science; (14) National Security; (15) Alternative Energy; and (16) Climatic Change.« less

Microfluidics for Positron Emission Tomography (PET) Imaging Probe Development

PubMed Central

Wang, Ming-Wei; Lin, Wei-Yu; Liu, Kan; Masterman-Smith, Michael; Shen, Clifton Kwang-Fu

2012-01-01

Due to increased needs for Positron Emission Tomography (PET) scanning, high demands for a wide variety of radiolabeled compounds will have to be met by exploiting novel radiochemistry and engineering technologies to improve the production and development of PET probes. The application of microfluidic reactors to perform radiosyntheses is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional labeling systems. Microfluidic-based radiochemistry can lead to the use of smaller quantities of precursors, accelerated reaction rates and easier purification processes with greater yield and higher specific activity of desired probes. Several ‘proof-of-principle’ examples, along with basics of device architecture and operation, and potential limitations of each design are discussed here. Along with the concept of radioisotope distribution from centralized cyclotron facilities to individual imaging centers and laboratories (“decentralized model”), an easy-to-use, standalone, flexible, fully-automated radiochemical microfluidic platform can open up to simpler and more cost-effective procedures for molecular imaging using PET. PMID:20643021

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jurisson, Silvia S.; Lever, Susan Z.; Robertson, J. David

This grant was situated at the University of Missouri to train Ph.D. scientists in radiochemistry and synthetic chemistry in conjunction with Faculty from the Interdisciplinary Plant Group, Division of Biological Sciences, the MU Research Reactor Center, Molecular Biology and the Radiopharmaceutical Sciences Institute. This project was collaborative with Brookhaven National Laboratory (Richard Ferrieri, PI). Projects for the Ph.D. candidates included novel probe development for peptides, nucleosides, small molecules or radiometals, the direct use of radiometals as probes, or nuclear techniques for analysis. The projects for the postdoctoral fellow involved synthetic chemistry for the preparation of precursors for novel tracers thatmore » will be radiolabeled with 18F or other appropriate radionuclides. The skill sets of our team members allowed us to prepare probes with positron or single photon emitters, as well as ones that are dual-labeled (fluorescent and radiolabeled). We focused our technical advances to those that will be broadly applicable to any research field.« less

Imaging of Prostate Cancer Using Gallium-68-Labeled Bombesin.

PubMed

Sonni, Ida; Baratto, Lucia; Iagaru, Andrei

2017-04-01

Nuclear medicine can play an important role in evaluating prostate cancer combining anatomical and functional information with hybrid techniques. Various PET radiopharmaceuticals have been used for targeting specific biological markers in prostate cancer. Research is ideally oriented towards the development of radiopharmaceuticals targeting antigens overexpressed in prostate cancer, as opposed to normal prostate tissue. In this regard, gastrin-releasing peptide receptors (GRPR) are excellent candidates. Bombesin analogues targeting the GRPR have been investigated. Gallium-68 ( 68 Ga) is an interesting PET radioisotope due to several advantages, such as availability, ease of radiochemistry, half-life, and costs. The focus of this review is on 68 Ga-labeled bombesin analogues in prostate cancer. Copyright © 2016 Elsevier Inc. All rights reserved.

Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes

PubMed Central

2015-01-01

Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear characteristics (97% β+ decay, 109.7 min half-life, 635 keV positron energy), along with high specific activity and ease of large scale production, make it an attractive nuclide for radiochemical labeling and molecular imaging. Versatile chemistry including nucleophilic and electrophilic substitutions allows direct or indirect introduction of 18F into molecules of interest. The significant increase in 18F radiotracers for PET imaging accentuates the need for simple and efficient 18F-labeling procedures. In this review, we will describe the current radiosynthesis routes and strategies for 18F labeling of small molecules and biomolecules. PMID:25473848

Separated isotopes: Vital tools for science and medicine

NASA Astrophysics Data System (ADS)

Deliberations and conclusions of a workshop on stable isotopes and derived radioisotopes organized by the Subcommittee on Nuclear and Radiochemistry of the National Research Council's Committee on Chemical Sciences at the request of the Department of Energy (DOE) are summarized. The workshop was jointly supported by the National Institutes of Health and DOE's Office of Basic Energy Sciences. An overview with three recommendations resulting from the workshop is followed by reports of the four workshop panels. Background papers were prepared by individuals on the Steering Committee and made available to all participants prior to the Workshop. They are reproduced as Appendixes 3 to 8. Short reports on alternate separation techniques were presented at the Workshop and are reproduced in Appendixes 9 to 11.

National cyclotron centre at the Institute for Nuclear Research and Nuclear Energy

NASA Astrophysics Data System (ADS)

Tonev, D.; Goutev, N.; Asova, G.; Artinyan, A.; Demerdjiev, A.; Georgiev, L. S.; Yavahchova, M.; Bashev, V.; Genchev, S. G.; Geleva, E.; Mincheva, M.; Nikolov, A.; Dimitrov, D. T.

2018-05-01

An accelerator laboratory is presently under construction in Sofia at the Institute for Nuclear Research and Nuclear Energy. The laboratory will use a TR24 type of cyclotron, which provides a possibility to accelerate a proton beam with an energy of 15 to 24 MeV and current of up to 0.4 mA. An accelerator with such parameters allows to produce a large variety of radioisotopes for development of radiopharmaceuticals. The most common radioisotopes that can be produced with such a cyclotron are PET isotopes like: 11C, 13N, 15O, 18F, 124I, 64Cu, 68Ge/68Ga, and SPECT isotopes like: 123I, 111In, 67Ga, 57Co, 99mTc. Our aim is to use the cyclotron facility for research in the fields of radiopharmacy, radiochemistry, radiobiology, nuclear physics, materials sciences, applied research, new materials and for education in all these fields including nuclear energy. Presently we perform investigations in the fields of target design for production of radioisotopes, shielding and radioprotection, new ion sources etc.

How to Make the 20-cent Fallout Meter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meade, Roger Allen; Rodriguez, Serena R.; Alvarez, Luis

Nobel Prize winner Luis Alvarez published an article on how to build a homemade fallout meter in the November 12, 1961, issue of the Sunday supplement This Week Magazine. A yellowed copy of the article was recently found in the files of the Radiochemistry Group, C-NR, and is reproduced below in its original form.

The Living Textbook of Nuclear Chemistry: A Peer-Reviewed, Web-Based, Education Resource

ERIC Educational Resources Information Center

Loveland, W.; Gallant, A.; Joiner, C.

2004-01-01

The recent developments in nuclear chemistry education are presented and an attempt is made to collect supplemental materials relating to the study and practice of nuclear chemistry. The Living Textbook of Nuclear Chemistry functions as an authoritative Web site with supplemental material for teaching nuclear and radiochemistry.

Automated radiosynthesis of no-carrier-added 4-[18F]fluoroiodobenzene: a versatile building block in 18F radiochemistry.

PubMed

Way, Jenilee Dawn; Wuest, Frank

2014-02-01

4-[18F]Fluoroiodobenzene ([18F]FIB) is a versatile building block in 18F radiochemistry used in various transition metal-mediated C-C and C-N cross-coupling reactions and [18F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [18F]FIB. However, to date, no automated synthesis of [18F]FIB has been reported to allow access to larger amounts of [18F]FIB in high radiochemical and chemical purity. Herein, we describe an automated synthesis of no-carrier-added [18F]FIB on a GE TRACERlab™ FX automated synthesis unit starting from commercially available(4-iodophenyl)diphenylsulfonium triflate as the labelling precursor. [18F]FIB was prepared in high radiochemical yields of 89 ± 10% (decay-corrected, n = 7) within 60 min, including HPLC purification. The radiochemical purity exceeded 95%, and specific activity was greater than 40 GBq/μmol. Typically, from an experiment, 6.4 GBq of [18F]FIB could be obtained starting from 10.4 GBq of [18F]fluoride.

Development of a beta-spectrometer using PIPS technology

PubMed

Courti; Goutelard; Burger; Blotin

2000-07-01

Various anthropogenic sources contribute to the inventory of long live beta-emitters in the environment. Studies have been carried out to obtain the 90Sr distribution in environment in order to estimate its impact in terms of radiation exposure to humans. The Laboratory routinely measures 90Sr by proportional counter after radiochemistry. An incomplete radiochemical separation leads to a deposit submitted to count polluted by natural beta-emitters. In order to confirm the result, 90Y (daughter of 90Sr), is extracted from the final radiochemical fraction and counted. The 90Y decreasing (T(1/2) = 2.67 days) is checked by successive counts over 64 h. The delay between the end of radiochemistry and the counting is imposed by 15 days to allow radioactive equilibrium between 90Sr and 90Y to be established. In order to remove this delay the purity of the 90Sr fraction source can be verified by beta-spectrometry. Thus, a beta-spectrometer is under development in collaboration with Canberra Semi-Conductor and Canberra Electronic. It consists in a PIPS detector where several silicon layers are combined. Initial results will be presented in this paper.

Recent progress in [11 C]carbon dioxide ([11 C]CO2 ) and [11 C]carbon monoxide ([11 C]CO) chemistry.

PubMed

Taddei, Carlotta; Gee, Antony D

2018-03-01

[ 11 C]Carbon dioxide ([ 11 C]CO 2 ) and [ 11 C]carbon monoxide ([ 11 C]CO) are 2 attractive precursors for labelling the carbonyl position (C═O) in a vast range of functionalised molecules (eg, ureas, amides, and carboxylic acids). The development of radiosynthetic methods to produce functionalised 11 C-labelled compounds is required to enhance the radiotracers available for positron emission tomography, molecular, and medical imaging applications. Following a brief summary of secondary 11 C-precursor production and uses, the review focuses on recent progress with direct 11 C-carboxylation routes with [ 11 C]CO 2 and 11 C-carbonylation with [ 11 C]CO. Novel approaches to generate [ 11 C]CO using CO-releasing molecules (CO-RMs), such as silacarboxylic acids and disilanes, applied to radiochemistry are described and compared with standard [ 11 C]CO production methods. These innovative [ 11 C]CO synthesis strategies represent efficient and reliable [ 11 C]CO production processes, enabling the widespread use of [ 11 C]CO chemistry within the wider radiochemistry community. Copyright © 2017 John Wiley & Sons, Ltd.

Separated isotopes: vital tools for science and medicine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1982-01-01

Deliberations and conclusions of a Workshop on Stable Isotopes and Derived Radioisotopes organized by the Subcommittee on Nuclear and Radiochemistry of the National Research Council's Committee on Chemical Sciences at the request of the Department of Energy (DOE) are summarized. The workshop was jointly supported by the National Institutes of Health and DOE's Office of Basic Energy Sciences. An overview with three recommendations resulting from the Workshop is followed by reports of the four Workshop panels. Background papers were prepared by individuals on the Steering Committee and made available to all participants prior to the Workshop. They are reproduced asmore » Appendixes 3 to 8. Short reports on alternate separation techniques were presented at the Workshop and are reproduced in Appendixes 9 to 11.« less

Cyclotron laboratory of the Institute for Nuclear Research and Nuclear Energy

NASA Astrophysics Data System (ADS)

Tonev, D.; Goutev, N.; Georgiev, L. S.

2016-06-01

An accelerator laboratory is presently under construction in Sofia at the Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences. The laboratory will use a TR24 type of cyclotron, which provides a possibility to accelerate a proton beam with an energy of 15 to 24 MeV and current of up to 0.4 mA. An accelerator with such parameters allows to produce a large variety of radioisotopes for development of radiopharmaceuticals. The most common radioisotopes that could be produced with such a cyclotron are PET isotopes like: 11C, 13N, 15O, 18F, 124I, 64Cu, 68Ge/68Ga, and SPECT isotopes like: 123I, 111In, 67Ga, 57Co, 99m Tc. Our aim is to use the cyclotron facility for research in the fields of radiopharmacy, radiochemistry, radiobiology, nuclear physics, solid state physics, applied research, new materials and for education in all these fields including nuclear energy. The building of the laboratory will be constructed nearby the Institute for Nuclear Research and Nuclear Energy and the cyclotron together with all the equipment needed will be installed there.

AN OVERVIEW ON PET RADIOCHEMISTRY: PART 2 - RADIOMETALS.

PubMed

Brandt, Marie; Cardinale, Jens; Aulsebrook, Margaret; Gasser, Gilles; Mindt, Thomas

2018-05-10

This continuing educational review provides an overview on radiometals used for PET. General aspects of radiometal-based radiotracers are covered and the most frequently applied metallic PET radionuclides 68 Ga, 89 Zr, and 64 Cu are highlighted with a discussion of their strengths and limitations. Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Separated isotopes: vital tools for science and medicine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1982-01-01

This report summarizes the deliberations and conclusions of a Workshop on Stable Isotopes and Derived Radioisotopes organized by the Subcommittee on Nuclear and Radiochemistry of the National Research Council's Committee on Chemical Sciences at the request of the Department of Energy (DOE). The workshop was jointly supported by the National Institutes of Health and DOE's Office of Basic Energy Sciences. An Overview with three recommendations resulting from the Workshop, prepared by the Steering Committee, is followed by Chapters 1 to 4, reports of the following four Workshop panels: (1) panel on research applications in physics, chemistry and geoscience; (2) panelmore » on commercial applications; (3) panel on biomedical research applications; (4) panel on clinical applications. Background papers were prepared by individuals on the Steering Committee and made available to all participants prior to the Workshop. They proved of great value and are reproduced as Appendixes 3 to 8. Short reports on alternate separation techniques were presented at the Workshop and are reproduced in Appendixes 9 to 11. Selected papers have been abstracted and indexed.« less

Isolation and Puification of Uranium Isotopes for Measurement by Mass-Spectrometry (233, 234, 235, 236, 238U) and Alpha Spectrometry (232U)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marinelli, R; Hamilton, T; Brown, T

2006-05-30

This report describes a standardized methodology used by researchers from the Center for Accelerator Mass Spectrometry (CAMS) (Energy and Environment Directorate) and the Environmental Radiochemistry Group (Chemistry and Materials Science Directorate) at the Lawrence Livermore National Laboratory (LLNL) for the full isotopic analysis of uranium from solution. The methodology has largely been developed for use in characterizing the uranium composition of selected nuclear materials but may also be applicable to environmental studies and assessments of public, military or occupational exposures to uranium using in-vitro bioassay monitoring techniques. Uranium isotope concentrations and isotopic ratios are measured using a combination of Multimore » Collector Inductively Coupled Plasma Mass Spectrometry (MC ICP-MS), Accelerator Mass Spectrometry (AMS) and Alpha Spectrometry.« less

Inter-laboratory comparison measurements of radiochemical laboratories in Slovakia.

PubMed

Meresová, J; Belanová, A; Vrsková, M

2010-01-01

The first inter-laboratory comparison organized by the radiochemistry laboratory of Water Research Institute (WRI) in Bratislava was carried out in 1993 and since then is it realized on an annual basis and about 10 radiochemical laboratories from all over Slovakia are participating. The gross alpha and gross beta activities, and the activity concentrations of (222)Rn, tritium, and (226)Ra, and U(nat) concentration in synthetic water samples are compared. The distributed samples are covering the concentration range prevailing in potable and surface waters and are prepared by dilution of certified reference materials. Over the course of the years 1993-2008, we observed the improvement in the quality of results for most of the laboratories. However, the success rate of the gross alpha determination activity is not improving as much as the other parameters. Copyright 2009 Elsevier Ltd. All rights reserved.

Pd-mediated rapid cross-couplings using [(11) C]methyl iodide: groundbreaking labeling methods in (11) C radiochemistry.

PubMed

Doi, Hisashi

2015-03-01

Prof. Bengt Långström is a pioneer in the field of chemistry-driven positron emission tomography (PET) imaging. He has developed a variety of excellent radiolabeling methodologies using the methods of organic chemistry, with the aim of widening the potential of PET in the study of life. Among his groundbreaking achievements in (11) C radiochemistry, there is the discovery of the Pd-mediated rapid cross-coupling reaction using [(11) C]methyl iodide. It was first reported by his Uppsala group in 1994-1995 and was further investigated by his and other groups with a view of enhancing its generality and practicability. This reaction is currently considered one of the basic methods for (11) C-labeling of low-weight organic compounds. This paper presents a short summary of the background and the development of Pd-mediated rapid cross-couplings of [(11) C]methyl iodide, with a focus not only on organostannanes, but also on organoboranes, organozincs, and terminal acetylene compounds. All these reactions have proven to be dependable (11) C-labeling methodologies that use chemically reliable carbon-carbon bond formation reactions. Copyright © 2015 John Wiley & Sons, Ltd.

Molecular Innovations Toward Theranostics of Aggressive Prostate Cancer

DTIC Science & Technology

2017-11-01

the positive control. 3. Proposed biodistribution, pharmacokinetics, and potential cytotoxicity evaluation experiments were accomplished. Task 4...Radiochemistry and in vitro assay of the synthesized theranostic agents (Sun/Hsieh) Task 5: In vivo and PET/CT imaging evaluation of the synthesized...were designed, synthesized and evaluated using a well-validated model ligand (integrin αvβ3 ligand). Our work suggests that the chirality of BFC

Modeled Neutron and Charged-Particle Induced Nuclear Reaction Cross Sections for Radiochemistry in the Region of Yttrium, Zirconium, Niobium, and Molybdenum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffman, R D; Kelley, K; Dietrich, F S

2006-06-13

We have developed a set of modeled nuclear reaction cross sections for use in radiochemical diagnostics. Systematics for the input parameters required by the Hauser-Feshbach statistical model were developed and used to calculate neutron, proton, and deuteron induced nuclear reaction cross sections for targets ranging from strontium (Z = 38) to rhodium (Z = 45).

Review of cyclotron production and quality control of ``High specific activity'' radionuclides for biomedical, biological, industrial and environmental applications at INFN-LASA

NASA Astrophysics Data System (ADS)

Birattari, C.; Bonardi, M.; Groppi, F.; Gini, L.

2001-12-01

At the "Radiochemistry Laboratory" of Accelerators and Applied Superconductivity Laboratory, LASA, a wide range of high specific activity radionuclides, RNs, have been produced in No Carrier Added form, for both basic research and application purposes. Use was made of the AVF proton cyclotron (K=45) of Milan University (up to 1987). More recently, the irradiations were carried out at the Scanditronix MC40 cyclotron (K=38; p, d, He-4 and He-3) of JRC-Ispra, Italy, of the European Community. In order to optimize the irradiation conditions for radioisotope production, a series of thin- and thick-target excitation functions have been experimentally determined. For each RN, a specific radiochemical separation has been developed in order to obtain GBq (mCi) amounts of the radiotracers in "high specific activity" No Carrier Added form (NCA).

Comparison of radium-228 determination in water among Australian laboratories.

PubMed

Zawadzki, Atun; Cook, Megan; Cutmore, Brodie; Evans, Fiona; Fierro, Daniela; Gedz, Alicea; Harrison, Jennifer J; Loosz, Tom; Medley, Peter; Mokhber-Shahin, Lida; Mullins, Sarah; Sdraulig, Sandra

2017-11-01

The National Health and Medical Research Council and Natural Resource Management Ministerial Council of Australia developed the current Australian Drinking Water Guidelines which recommend an annual radiation dose value of 1 mSv year -1 . One of the potential major contributors to the radiation dose from drinking water is radium-228, a naturally occurring radionuclide arising from the thorium decay series. Various methods of analysing for radium-228 in water have been established and adapted by analytical radiochemistry laboratories. Seven laboratories in Australia participated in analysing radium-228 spiked water samples with activity concentrations ranging from 6 mBq L -1 to 20 Bq L -1 . The aim of the exercise was to compare and evaluate radium-228 results reported by the participating laboratories, the methods used and the detection limits. This paper presents the outcome of the exercise. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

Expedited Synthesis of Fluorine-18 Labeled Phenols. A Missing Link in PET Radiochemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katzenellenbogen, John A.; Zhou, Dong

Fluorine-18 (F-18) is arguably the most valuable radionuclide for positron emission tomographic (PET) imaging. However, while there are many methods for labeling small molecules with F-18 at aliphatic positions and on electron-deficient aromatic rings, there are essentially no reliable and practical methods to label electron-rich aromatic rings such as phenols, with F-18 at high specific activity. This is disappointing because fluorine-labeled phenols are found in many drugs; there are also many interesting plant metabolites and hormones that contain either phenols or other electron-rich aromatic systems such as indoles whose metabolism, transport, and distribution would be interesting to study if theymore » could readily be labeled with F-18. Most approaches to label phenols with F-18 involve the labeling of electron-poor precursor arenes by nucleophilic aromatic substitution, followed by subsequent conversion to phenols by oxidation or other multi-step sequences that are often inefficient and time consuming. Thus, the lack of good methods for labeling phenols and other electron-rich aromatics with F-18 at high specific activity represents a significant methodological gap in F-18 radiochemistry that can be considered a “Missing Link in PET Radiochemistry”. The objective of this research project was to develop and optimize a series of unusual synthetic transformations that will enable phenols (and other electron-rich aromatic systems) to be labeled with F-18 at high specific activity, rapidly, reliably, and conveniently, thereby bridging this gap. Through the studies conducted with support of this project, we have substantially advanced synthetic methodology for the preparation of fluorophenols. Our progress is presented in detail in the sections below, and much has been published or presented publication; other components are being prepared for publication. In essence, we have developed a completely new method to prepare o-fluorophenols from non-aromatic precursors (diazocyclohexenones) by a novel reaction sequence that uses fluoride ion as a precursor and various activating electrophiles, and we have improved methods for the preparation of heterodiaryl iodonium salts. Both methods have been used to prepare interesting potential radiotracers. Other advances have been made in labeling dendrimeric nanoparticle structures of increasing interest for multimodal imaging and in advancing labeling through fluorosilane bonds. Thus, the progress we have made substantially fills the significant gap in PET radiochemistry that we originally identified, and it provides for the field new methodology that can be applied to a number of current challenges, including the preparation of several molecules of interest as radiotracers, such as 2-[18F]Fluoroestradiol (2-FES) and m-fluorotyrosine, which we have illustrated. These methods can be used by any skilled radiochemist interesting in preparing these agents or similar fluorine-18 labeled electron-rich arene systems of interested for PET biological imaging in the most general sense.« less

The development, past achievements, and future directions of brain PET

PubMed Central

Jones, Terry; Rabiner, Eugenii A

2012-01-01

The early developments of brain positron emission tomography (PET), including the methodological advances that have driven progress, are outlined. The considerable past achievements of brain PET have been summarized in collaboration with contributing experts in specific clinical applications including cerebrovascular disease, movement disorders, dementia, epilepsy, schizophrenia, addiction, depression and anxiety, brain tumors, drug development, and the normal healthy brain. Despite a history of improving methodology and considerable achievements, brain PET research activity is not growing and appears to have diminished. Assessments of the reasons for decline are presented and strategies proposed for reinvigorating brain PET research. Central to this is widening the access to advanced PET procedures through the introduction of lower cost cyclotron and radiochemistry technologies. The support and expertize of the existing major PET centers, and the recruitment of new biologists, bio-mathematicians and chemists to the field would be important for such a revival. New future applications need to be identified, the scope of targets imaged broadened, and the developed expertize exploited in other areas of medical research. Such reinvigoration of the field would enable PET to continue making significant contributions to advance the understanding of the normal and diseased brain and support the development of advanced treatments. PMID:22434067

Automation of (64)Cu production at Turku PET Centre.

PubMed

Elomaa, Viki-Veikko; Jurttila, Jori; Rajander, Johan; Solin, Olof

2014-07-01

At Turku PET Centre automation for handling solid targets for the production of (64)Cu has been built. The system consists of a module for moving the target from the irradiation position into a lead transport shield and a robotic-arm assisted setup for moving the target within radiochemistry laboratory. The main motivation for designing automation arises from radiation hygiene. Copyright © 2014 Elsevier Ltd. All rights reserved.

Radiochemistry Research and Training, UC Davis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutcliffe, Julie

2012-08-01

The report contains a summary of the accomplishments made during the R2@UCDavis proposal. In brief we proposed to develop new and highly innovative radiotracer methods and to enhance training opportunities to ensure the future availability of human resources for highly specialized fields of radiotracer development chemistry and clinical nuclear medicine research and allied disciplines. The overall scientific objectives of this proposal were to utilize “click” chemistry to facilitate fast and site-specific radiolabeling. Progress was made on all initial goals presented. This funding has to date resulted in publications in high impact journals such as Acta Biomaterialia, Molecular Imaging and Biology,more » Nuclear Medicine and Biology and most recently Environmental Science and technology, and it is anticipated that through the collaborations established during the time course of this funding that future research will be published in clinically relevant journals such as Science Translational Medicine and the Journal of Nuclear Medicine. Trainees involved in this proposal have gone on to further their careers in both academia, industry and the private sector. The collaborative forums established during the time course of this funding will ensure the future availability of human resources for highly specialized fields of radiotracer development chemistry and clinical nuclear medicine research and allied disciplines.« less

Molecular Innovations Toward Theranostics of Aggressive Prostate Cancer

DTIC Science & Technology

2015-09-01

Xiankai Sun, PhD CONTRACTING ORGANIZATION: University of Texas Southwestern Medical Center, Dallas, TX 75390 REPORT DATE : September 2015 TYPE OF REPORT...number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) September 2015 2. REPORT TYPE Annual 3. DATES COVERED (From...toxicity. To date , we have developed the radiochemistry procedure to label the T-SMDC with 68Ga efficiently. We have started evaluating its therapeutic

Current research in nuclear medicine and molecular imaging in Italy: highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging.

PubMed

Cuocolo, A

2011-06-01

The 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (AIMN) took place in Rimini on March 18-21, 2011 under the chairmanship of Professor Stefano Fanti. The program was of excellent quality and put a further step for the settlement of the standardized AIMN congress structure. A large industrial exhibition demonstrated the latest technological innovations and developments within the field. The congress was a great success with more than 1100 total participants and more than 360 abstracts received. Of these, 40 abstracts were accepted for oral and 285 for poster presentations. The original investigations presented were related to different areas of nuclear medicine and molecular imaging, with particular focus on advances in instrumentation and data processing, progress in radiochemistry and pharmacy, novel diagnostics and therapeutics, and new insights in well established areas of clinical application, such as oncology, cardiology, neurology, psychiatry, endocrinology, paediatrics, and infection and inflammation. Noteworthy, several presentations at this congress, focusing on quantitative interpretation of the imaging data and on pragmatic endpoints, such as adverse outcomes, identified when nuclear medicine procedures achieved clinical effectiveness for patient care and patient management and further demonstrated that nuclear medicine plays a crucial role in the contemporary medical scenario. This highlights lecture is only a brief summary of the large amount of data presented and discussed, which can be found in much greater detail in the congress abstract book, published as volume 55, supplement 1 of the Q J Nucl Med Mol Imaging in April 2011.

United States Transuranium and Uranium Registries. Annual Report, October 1, 1993--September 30, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kathren, R.L.; Harwick, L.A.

1995-08-01

This report summarizes the salient activities and progress of the United States Transuranium. and Uranium Registries for the period October 1, 1993 through September 30, 1994, along with details of specific programs areas including the National Human Radiobiology Tissue Repository (NHRTR) and tissue radiochemistry analysis project. Responsibility for tissue radioanalysis was transferred from Los Alamos National Laboratory to Washington State University in February 1994. The University of Washington was selected as the Quality Assurance/Quality Control laboratory and a three way intercomparison with them and LANL has been initiated. The results of the initial alpha spectrometry intercomparison showed excellent agreement amongmore » the laboratories and are documented in full in the Appendices to the report. The NHRTR serves as the initial point of receipt for samples received from participants in the USTUR program. Samples are weighed, divided, and reweighed, and a portion retained by the NHRTR as backup or for use in other studies. Tissue specimens retained in the NHRTR are maintained frozen at -70 C and include not only those from USTUR registrants but also those from the radium dial painter and thorium worker studies formerly conducted by Argonne National Laboratory. In addition, there are fixed tissues and a large collection of histopathology slides from all the studies, plus about 20,000 individual solutions derived from donated tissues. These tissues and tissue related materials are made available to other investigators for legitimate research purposes. Ratios of the concentration of actinides in various tissues have been used to evaluate the biokinetics, and retention half times of plutonium and americium. Retention half times for plutonium in various soft tissues range from 10-20 y except for the testes for which a retention half time of 58 y was observed. For americium, the retention half time in various soft tissues studied was 2.2-3.5 y.« less

Nuclear Forensics and Radiochemistry: Cross Sections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rundberg, Robert S.

The neutron activation of components in a nuclear device can provide useful signatures of weapon design or sophistication. This lecture will cover some of the basics of neutron reaction cross sections. Nuclear reactor cross sections will also be presented to illustrate the complexity of convolving neutron energy spectra with nuclear excitation functions to calculate useful effective reactor cross sections. Deficiencies in the nuclear database will be discussed along with tools available at Los Alamos to provide new neutron cross section data.

The metabolism of the human brain studied with positron emission tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greitz, T.; Ingvar, D.H.; Widen, L.

1985-01-01

This volume presents coverage of the use of positron emission tomography (PET) to study the human brain. The contributors assess new developments in high-resolution positron emission tomography, cyclotrons, radiochemistry, and tracer kinetic models, and explore the use of PET in brain energy metabolism, blood flow, and protein synthesis measurements, receptor analysis, and pH determinations, In addition, they discuss the relevance and applications of positron emission tomography from the perspectives of physiology, neurology, and psychiatry.

ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

MICHAEL R. ZALUTSKY

2012-08-08

Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice hasmore » been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At-labeled targeted radiotherapeutics currently is a daunting task. Our central hypothesis is that improvements in 211At radiochemistry are critically dependent on gaining an understanding of and compensating for the effects of radiolysis induced by 211At {alpha}-particles. Because of the widespread interest in labeling antibodies, antibody fragments and peptides with 211At, our proposed work plan will initially focus on reagents that we have developed for this purpose. Part of our strategy is the use of synthetic precursors immobilized on polymeric resins or perfluorous and triarylphosphonium supports. Their use could eliminate the need for a purification step to separate unreacted tin precursor from labeled product and hopefully provide a simple kit technology that could be utilized at other institutions. The specific aims of this project are: (1) To optimze methods for 211At production and isolation of 211At from cyclotron targets; (2) To develop convenient and reproducible methodologies for high activity level and high specific activity radiohalogenation of biomolecules with 211At; (3) to develop a procedure for extending the shelf-life of 211At beyond a few hours so that this radionuclide can be utilized at centers remote from its site of production; and (4) to work out high activity level synthesis methods for utilizing support immobilized tin precursors for 211At labeling. If we are successful in achieving our goals, the radiochemical methodologies that are developed could greatly facilitate the use of 211At-labeled targeted cancer therapeutics in patients, even at institutions that are distant from the few sites currently available for 211At production.« less

PET Studies in Nonhuman Primate Models of Cocaine Abuse: Translational Research Related to Vulnerability and Neuroadaptations

PubMed Central

Gould, Robert W.; Duke, Angela N.; Nader, Michael A.

2013-01-01

The current review highlights the utility of positron emission tomography (PET) imaging to study the neurobiological substrates underlying vulnerability to cocaine addiction and subsequent adaptations following chronic cocaine self-administration in nonhuman primate models of cocaine abuse. Environmental (e.g., social rank) and sex-specific influences on dopaminergic function and sensitivity to the reinforcing effects of cocaine are discussed. Cocaine-related cognitive deficits have been hypothesized to contribute to high rates of relapse and are described in nonhuman primate models. Lastly, the long-term consequences of cocaine on neurobiology are discussed. PET imaging and longitudinal, within-subject behavioral studies in nonhuman primates have provided a strong framework for designing pharmacological and behavioral treatment strategies to aid drug-dependent treatment seekers. Non-invasive PET imaging will allow for individualized treatment strategies. Recent advances in radiochemistry of novel PET ligands and other imaging modalities can further advance our understanding of stimulant use on the brain. PMID:23458573

Nuclear Research Reactor IEA-R1 - A Study of the Preparing for Decommissioning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopes, Valdir Maciel; Filho, Tufic Madi; Ricci, Walter

2015-07-01

The Institute of Energy and Nuclear Research (IPEN), Sao Paulo, according to the assignments given by the National Commission of Nuclear Energy (CNEN), enabled the development of this study, especially operational reports about refurbishing carried out on 2013, involving the production of radioisotopes and research in the areas of Radiochemistry and Nuclear Physics. These reports are made in accordance with established standard procedures to meet the requirements of CNEN (National Nuclear Energy Commission, the regulator the nuclear area activities in Brazil) and IAEA (International Atomic Energy Agency). This study presents an assessment of the procedures and methods of treatments formore » decontamination of the refrigeration primary circuit and changes parts, equipment and tubes of the of the IEA-R1 nuclear research reactor, pool type, power between 3,5 and 4,5 MW. In order to have a sequence in the work, the well-known contaminant radioisotopes were evaluated firstly, using Geiger- Muller equipment. In the second phase, the decontamination was done manually together with the ultrasound cleaning and washing equipment. From the several water solutions of citric acid assessment, the concentration with better confidence was obtained; in order to achieve the best results for decontamination. This study intends to define the best process for decontamination with low taxes of waste and without expensive costs. (authors)« less

Simplified programming and control of automated radiosynthesizers through unit operations.

PubMed

Claggett, Shane B; Quinn, Kevin M; Lazari, Mark; Moore, Melissa D; van Dam, R Michael

2013-07-15

Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to be created from sequences of low-level, non-intuitive hardware operations. In some cases, the user is even responsible for adding steps to update the graphical representation of the system. In light of these unnecessarily complex approaches, we have created software to perform radiochemistry on the ELIXYS radiosynthesizer with the goal of being intuitive and easy to use. Radiochemists were consulted, and a wide range of radiosyntheses were analyzed to determine a comprehensive set of basic chemistry unit operations. Based around these operations, we created a software control system with a client-server architecture. In an attempt to maximize flexibility, the client software was designed to run on a variety of portable multi-touch devices. The software was used to create programs for the synthesis of several 18F-labeled probes on the ELIXYS radiosynthesizer, with [18F]FDG detailed here. To gauge the user-friendliness of the software, program lengths were compared to those from other systems. A small sample group with no prior radiosynthesizer experience was tasked with creating and running a simple protocol. The software was successfully used to synthesize several 18F-labeled PET probes, including [18F]FDG, with synthesis times and yields comparable to literature reports. The resulting programs were significantly shorter and easier to debug than programs from other systems. The sample group of naive users created and ran a simple protocol within a couple of hours, revealing a very short learning curve. The client-server architecture provided reliability, enabling continuity of the synthesis run even if the computer running the client software failed. The architecture enabled a single user to control the hardware while others observed the run in progress or created programs for other probes. We developed a novel unit operation-based software interface to control automated radiosynthesizers that reduced the program length and complexity and also exhibited a short learning curve. The client-server architecture provided robustness and flexibility.

Simplified programming and control of automated radiosynthesizers through unit operations

PubMed Central

2013-01-01

Background Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to be created from sequences of low-level, non-intuitive hardware operations. In some cases, the user is even responsible for adding steps to update the graphical representation of the system. In light of these unnecessarily complex approaches, we have created software to perform radiochemistry on the ELIXYS radiosynthesizer with the goal of being intuitive and easy to use. Methods Radiochemists were consulted, and a wide range of radiosyntheses were analyzed to determine a comprehensive set of basic chemistry unit operations. Based around these operations, we created a software control system with a client–server architecture. In an attempt to maximize flexibility, the client software was designed to run on a variety of portable multi-touch devices. The software was used to create programs for the synthesis of several 18F-labeled probes on the ELIXYS radiosynthesizer, with [18F]FDG detailed here. To gauge the user-friendliness of the software, program lengths were compared to those from other systems. A small sample group with no prior radiosynthesizer experience was tasked with creating and running a simple protocol. Results The software was successfully used to synthesize several 18F-labeled PET probes, including [18F]FDG, with synthesis times and yields comparable to literature reports. The resulting programs were significantly shorter and easier to debug than programs from other systems. The sample group of naive users created and ran a simple protocol within a couple of hours, revealing a very short learning curve. The client–server architecture provided reliability, enabling continuity of the synthesis run even if the computer running the client software failed. The architecture enabled a single user to control the hardware while others observed the run in progress or created programs for other probes. Conclusions We developed a novel unit operation-based software interface to control automated radiosynthesizers that reduced the program length and complexity and also exhibited a short learning curve. The client–server architecture provided robustness and flexibility. PMID:23855995

Development of an automated modular system for the synthesis of [11C]acetate.

PubMed

Felicini, Chiara; Någren, Kjell; Berton, Andrea; Pascali, Giancarlo; Salvadori, Piero Alberto

2010-12-01

Carboxylation reactions offer a straightforward method for the synthesis of carbon-11 labelled carboxylic acids. Among these, the preparation of carbon-11 (C)-acetate is receiving increasing attention because of diagnostic applications in oncology in addition to its well-established use as a probe for myocardial oxidative metabolism. Although a number of dedicated modules are commercially available, the development of the synthesis on flexible platforms would be beneficial to widen the number of tracers, in particular for preclinical assessment and testing. In this study, the carboxylation reaction was implemented for the synthesis of sodium 1-[C]acetate after the classic route of carboxylation of methylmagnesium chloride by [C]carbon dioxide, followed by the acidic hydrolysis, purification and sterile filtration. This was performed using a commercially available kit of preassembled hardware units and fully compatible components of radiochemistry automation (VarioSystem). The system proved be to highly versatile and inexpensive and allowed a quick translation of the radiochemistry project into a working system even by less experienced personnel, because of predefined interfaces between electronic parts and operating software (preloaded on a laptop and included in the kit). The automatic module proved to be a simple and reliable system for the production of 1-[C]acetate that was prepared in 24 min (total synthesis time) with stable radiochemical yields (20% nondecay corrected) and high radiochemical purity (>97%). The module is used routinely to produce 1-[C]acetate for preclinical studies and is being implemented for the production of the labelled fatty acids.

Nuclear Forensics and Radiochemistry: Reaction Networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rundberg, Robert S.

In the intense neutron flux of a nuclear explosion the production of isotopes may occur through successive neutron induced reactions. The pathway to these isotopes illustrates both the complexity of the problem and the need for high quality nuclear data. The growth and decay of radioactive isotopes can follow a similarly complex network. The Bateman equation will be described and modified to apply to the transmutation of isotopes in a high flux reactor. A alternative model of growth and decay, the GD code, that can be applied to fission products will also be described.

Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions

PubMed Central

Carroll, Valerie; Demoin, Dustin W.; Hoffman, Timothy J; Jurisson, Silvia S

2013-01-01

Summary Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions. PMID:25382874

Separation of Bismuth from Lead with (Ethylenediamine)tetraacetic Acid. Application to Radiochemistry; SEPARACAO DE BISMUTO DO CHUMBO COM ACIDO ETILENODIAMINOTETRAACETICO APLICACAO PARA RADIOQUIMICA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lima, F.W.; Abrao, A.

1958-09-01

Bismuth can be separated from lead radiochemically by using (ethylenediamine)tetraacetic acid. The separation is successful when both elements are in trace concentration when one is in trace concentrations and other in macroconcentrations, and when both are in macroconcentrations. A single separation gives more than 90% of both elements. The process involves simple manipulations and can be done in less than fifteen minutes, which is of importance in the separation of short-lived isotopes. (tr-auth)

Careers and people

NASA Astrophysics Data System (ADS)

2008-04-01

Nuclear scientists needed The US is heading for a serious shortage of nuclear forensics experts, according to a new report by the American Physical Society (APS) and the American Association for the Advancement of Science (AAAS). Nuclear forensics involves using sophisticated technology to analyse the nature, use and origin of nuclear materials, and is key to monitoring the illicit trade in and use of nuclear weapons. Currently there are fewer than 50 nuclear forensic scientists working in the US's network of national laboratories - not enough, the report claims, to deal with an emergency - and half of them are expected to retire within the next 15 years. As university programmes in radiochemistry and related subjects have been dwindling, there are not nearly enough young scientists to replenish the expertise pool. The report calls for a new programme to develop nuclear forensic scientists that would involve funding research at universities, launching graduate scholarships and fellowships, as well as setting up internships for young scientists at the labs where this work is carried out. Stimulating industrial support of faculty positions is also deemed important. Indeed, at least three or four new postdocs need to be hired into nuclear forensics every year for the next 10 years, the report says. It also recognizes that more research is needed to develop new lab and field equipment, and to create better numerical-simulation techniques.

Measurements and evaluation of the risks due to external radiation exposures and to intake of activated elements for operational staff engaged in the maintenance of medical cyclotrons.

PubMed

Calandrino, R; del Vecchio, A; Parisi, R; Todde, S; De Felice, P; Savi, A; Pepe, A; Mrskova, A

2010-06-01

The aim of this paper is to assess the activation phenomena and to evaluate the risk of external exposure and intake doses for the maintenance staff of two medical cyclotrons. Two self-shielded cyclotrons are currently operating in the facility for the routine production of (11)C and (18)F. Four radiochemistry laboratories are linked to the cyclotrons by means of shielded radioisotope delivery lines. Radiopharmaceuticals are prepared both for the PET Diagnostic Department, where four CT-PET scanners are operating with a mean patient workload of 40 d(-1) and for [(18)F]FDG external distribution, to provide radiopharmaceuticals for other institutions. In spite of the fact that air contamination inside the radiochemistry laboratories during the synthesis represents the largest 'slice of the pie' in the evaluation of annual intake dose, potential contamination due to the activated particulate, generated during cyclotron irradiation by micro-corrosion of targets and other components potentially struck by the proton beam and generated neutrons, should be considered. In this regard, the most plausible long-lived (T(1/2) > 30 d) radioisotopes formed are: (97)Tc, (56)Co, (57)Co, (58)Co, (60)Co, (49)V, (55)Fe, (109)Cd, (65)Zn and (22)Na. The results for the operating personnel survey has revealed only low-level contamination for (65)Zn in one test, together with minor (18)F intake, probably due to the environmental dispersion of the radioisotope during the [(18)F]FDG synthesis.

Chemical Research--Radiochemistry Report for Month Ending April 17, 1943

DOE R&D Accomplishments Database

Franck, J. Division Director

1952-01-01

1. A continuation of the detailed analysis of beta and soft and hard gamma activity associated with all fission product elements in a nitrate bombardment is presented. The ?cooling? time has been extended to 170 days. The data for the individual elements are presented in tables as counts/min and in figures as percentage of total beta, soft gamma, and hard gamma radiations. 2. Calculations and graphs have been made on the heat generated by the longer-lived fission products. The method of analysis is presented. 3. Two new short-lived Rh fission product activities have been found. They are probably the daughters of the two long-lived Ru activities (30d, 200d). Re-evaluation of data on 43 leads to the conclusion that the longest lived 43 activity in measureable yields is the 6.1h (formerly 6.6h). New parent-daughter relationships in the rare-earth activities are given. 4. Theoretical beta absorption curves have been made using the Fermi distribution function and linear absorption curves for small energy intervals. A Feather analysis of the absorption curve leads to the theoretical maximum energy.

Low current performance of the Bern medical cyclotron down to the pA range

NASA Astrophysics Data System (ADS)

Auger, M.; Braccini, S.; Ereditato, A.; Nesteruk, K. P.; Scampoli, P.

2015-09-01

A medical cyclotron accelerating H- ions to 18 MeV is in operation at the Bern University Hospital (Inselspital). It is the commercial IBA 18/18 cyclotron equipped with a specifically conceived 6 m long external beam line ending in a separate bunker. This feature is unique for a hospital-based facility and makes it possible to conduct routine radioisotope production for PET diagnostics in parallel with multidisciplinary research activities, among which are novel particle detectors, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. Several of these activities, such as radiobiology experiments for example, require low current beams down to the pA range, while medical cyclotrons are designed for high current operation above 10 μA. In this paper, we present the first results on the low current performance of a PET medical cyclotron obtained by ion source, radio-frequency and main coil tuning. With this method, stable beam currents down to (1.5+/- 0.5 ) pA were obtained and measured with a high-sensitivity Faraday cup located at the end of the beam transport line.

PREFACE: 11th International Workshop on Positron and Positronium Chemistry (PPC-11)

NASA Astrophysics Data System (ADS)

Pujari, P. K.; Sudarshan, K.; Dutta, D.

2015-06-01

The International Workshop on Positron and Positronium Chemistry (PPC) is a prestigious triennial conference series with a rich history. The 11th meeting in the series (PPC-11) was held at Cidade de Goa, Goa, India during 9-14, November, 2014. It was organized by Bhabha Atomic Research Centre (BARC), Mumbai. The co-organizers were Saha Institute of Nuclear Physics (SINP), Kolkata, Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam and Indian Association of Nuclear Chemists and Allied Scientists (IANCAS), Mumbai. PPC-11 attracted participants both from academic institutions and industries. About 120 participants from 20 countries representing all continents participated in the conference. The conference continued the tradition of excellence in terms of quality of presentations and discussions. There were 33 plenary and invited talks, 39 oral presentations and 40 posters. The conference stood true to its multidisciplinary tag with papers presented in the fields of fundamentals of positron and positronium chemistry, applications in polymers, porous materials, metals/alloys, studies in liquids, biological applications as well as developments in theory and experimental techniques. The enthusiastic participation of senior researchers and young students made the scientific program a grand success. In order to encourage the student participants (twenty) and promote excellence, a committee of senior members evaluated their presentations and the top three contributions were awarded. The positron and positronium community paid homage to the memory of late Profs. J. Kristiak and A.T. Stewart. A brief sketch of their life and work was presented by Profs. Jan Kuriplach and Toshio Hyodo, respectively. All the papers published in these proceedings have been peer reviewed by the participants of PPC-11. Editors thank all the reviewers for sparing their valuable time and helping us in bringing out the proceedings with 43 contributed articles in the scheduled time. We are grateful to the members of the International scientific committee, members of the organizing committee and advisory committee for their support. We wish to thank the members of the positron group at the Radiochemistry Division, Bhabha Atomic Research Centre for shouldering the responsibility of organizing the conference and making it a memorable event. We wish to conclude by wishing success to the organizers of PPC-12 and hope to meet you all in Poland.

Management of radioactive waste gases from PET radiopharmaceutical synthesis using cost effective capture systems integrated with a cyclotron safety system.

PubMed

Stimson, D H R; Pringle, A J; Maillet, D; King, A R; Nevin, S T; Venkatachalam, T K; Reutens, D C; Bhalla, R

2016-09-01

The emphasis on the reduction of gaseous radioactive effluent associated with PET radiochemistry laboratories has increased. Various radioactive gas capture strategies have been employed historically including expensive automated compression systems. We have implemented a new cost-effective strategy employing gas capture bags with electronic feedback that are integrated with the cyclotron safety system. Our strategy is suitable for multiple automated 18 F radiosynthesis modules and individual automated 11 C radiosynthesis modules. We describe novel gas capture systems that minimize the risk of human error and are routinely used in our facility.

Dissolution of aerosol particles collected from nuclear facility plutonium production process

DOE PAGES

Xu, Ning; Martinez, Alexander; Schappert, Michael Francis; ...

2015-08-14

Here, a simple, robust analytical chemistry method has been developed to dissolve plutonium containing particles in a complex matrix. The aerosol particles collected on Marple cascade impactor substrates were shown to be dissolved completely with an acid mixture of 12 M HNO 3 and 0.1 M HF. A pressurized closed vessel acid digestion technique was utilized to heat the samples at 130 °C for 16 h to facilitate the digestion. The dissolution efficiency for plutonium particles was 99 %. The resulting particle digestate solution was suitable for trace elemental analysis and isotope composition determination, as well as radiochemistry measurements.

Occurrence of $sup 137$Cs in the biosphere evaluated with environmental and metabolic studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haesaenen, E.

This work forms a part of the fall-out studies carried out in the Department of Radiochemistry, University of Helsinki. Its main emphasis has been on the $gamma$-spectrometric determination of the $sup 137$Cs-levels and changes herein in different environmental samples and in man after the second nuclear testing period in 1961--1962. Special attention has been paid to the aquatic foodchains of $sup 137$Cs, to the foodchain reindeer-lichen-man, and to the biological half-life of $sup 137$Cs in man and in certain fish species. (auth)

BAYES’ THEOREM AND EARLY SOLAR SHORT-LIVED RADIONUCLIDES: THE CASE FOR AN UNEXCEPTIONAL ORIGIN FOR THE SOLAR SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Young, Edward D., E-mail: eyoung@epss.ucla.edu

2016-08-01

The presence of excesses of short-lived radionuclides in the early solar system evidenced in meteorites has been taken as testament to close encounters with exotic nucleosynthetic sources, including supernovae or AGB stars. An analysis of the likelihoods associated with different sources of these extinct nuclides in the early solar system indicates that, rather than being exotic, their abundances were typical of star-forming regions like those observed today in the Galaxy. The radiochemistry of the early solar system is therefore unexceptional, being the consequence of extensive averaging of solids from molecular clouds.

The Basic Principles of FDG-PET/CT Imaging.

PubMed

Basu, Sandip; Hess, Søren; Nielsen Braad, Poul-Erik; Olsen, Birgitte Brinkmann; Inglev, Signe; Høilund-Carlsen, Poul Flemming

2014-10-01

Positron emission tomography (PET) imaging with 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) forms the basis of molecular imaging. FDG-PET imaging is a multidisciplinary undertaking that requires close interdisciplinary collaboration in a broad team comprising physicians, technologists, secretaries, radio-chemists, hospital physicists, molecular biologists, engineers, and cyclotron technicians. The aim of this review is to provide a brief overview of important basic issues and considerations pivotal to successful patient examinations, including basic physics, instrumentation, radiochemistry, molecular and cell biology, patient preparation, normal distribution of tracer, and potential interpretive pitfalls. Copyright © 2014 Elsevier Inc. All rights reserved.

Analytical Chemistry Developmental Work Using a 243Am Solution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spencer, Khalil J.; Stanley, Floyd E.; Porterfield, Donivan R.

2015-02-24

This project seeks to reestablish our analytical capability to characterize Am bulk material and develop a reference material suitable to characterizing the purity and assay of 241Am oxide for industrial use. The tasks associated with this phase of the project included conducting initial separations experiments, developing thermal ionization mass spectrometry capability using the 243Am isotope as an isotope dilution spike , optimizing the spike for the determination of 241Pu- 241 Am radiochemistry, and, additionally, developing and testing a methodology which can detect trace to ultra- trace levels of Pu (both assay and isotopics) in bulk Am samples .

Radiochemistry, PET Imaging, and the Internet of Chemical Things

PubMed Central

2016-01-01

The Internet of Chemical Things (IoCT), a growing network of computers, mobile devices, online resources, software suites, laboratory equipment, synthesis apparatus, analytical devices, and a host of other machines, all interconnected to users, manufacturers, and others through the infrastructure of the Internet, is changing how we do chemistry. While in its infancy across many chemistry laboratories and departments, it became apparent when considering our own work synthesizing radiopharmaceuticals for positron emission tomography (PET) that a more mature incarnation of the IoCT already exists. How does the IoCT impact our lives today, and what does it hold for the smart (radio)chemical laboratories of the future? PMID:27610410

Radiochemistry, PET Imaging, and the Internet of Chemical Things.

PubMed

Thompson, Stephen; Kilbourn, Michael R; Scott, Peter J H

2016-08-24

The Internet of Chemical Things (IoCT), a growing network of computers, mobile devices, online resources, software suites, laboratory equipment, synthesis apparatus, analytical devices, and a host of other machines, all interconnected to users, manufacturers, and others through the infrastructure of the Internet, is changing how we do chemistry. While in its infancy across many chemistry laboratories and departments, it became apparent when considering our own work synthesizing radiopharmaceuticals for positron emission tomography (PET) that a more mature incarnation of the IoCT already exists. How does the IoCT impact our lives today, and what does it hold for the smart (radio)chemical laboratories of the future?

Rapid Radiochemical Methods for Asphalt Paving Material ...

EPA Pesticide Factsheets

Technical Brief Validated rapid radiochemical methods for alpha and beta emitters in solid matrices that are commonly encountered in urban environments were previously unavailable for public use by responding laboratories. A lack of tested rapid methods would delay the quick determination of contamination levels and the assessment of acceptable site-specific exposure levels. Of special concern are matrices with rough and porous surfaces, which allow the movement of radioactive material deep into the building material making it difficult to detect. This research focuses on methods that address preparation, radiochemical separation, and analysis of asphalt paving materials and asphalt roofing shingles. These matrices, common to outdoor environments, challenge the capability and capacity of very experienced radiochemistry laboratories. Generally, routine sample preparation and dissolution techniques produce liquid samples (representative of the original sample material) that can be processed using available radiochemical methods. The asphalt materials are especially difficult because they do not readily lend themselves to these routine sample preparation and dissolution techniques. The HSRP and ORIA coordinate radiological reference laboratory priorities and activities in conjunction with HSRP’s Partner Process. As part of the collaboration, the HSRP worked with ORIA to publish rapid radioanalytical methods for selected radionuclides in building material matrice

Radiochemistry, PET Imaging, and the Internet of Chemical Things

DOE PAGES

Thompson, Stephen; Kilbourn, Michael R.; Scott, Peter J. H.

2016-08-16

The Internet of Chemical Things (IoCT), a growing network of computers, mobile devices, online resources, software suites, laboratory equipment, synthesis apparatus, analytical devices, and a host of other machines, all interconnected to users, manufacturers, and others through the infrastructure of the Internet, is changing how we do chemistry. While in its infancy across many chemistry laboratories and departments, it became apparent when considering our own work synthesizing radiopharmaceuticals for positron emission tomography (PET) that a more mature incarnation of the IoCT already exists. Finally, how does the IoCT impact our lives today, and what does it hold for the smartmore » (radio)chemical laboratories of the future?« less

Radiochemistry, PET Imaging, and the Internet of Chemical Things

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, Stephen; Kilbourn, Michael R.; Scott, Peter J. H.

The Internet of Chemical Things (IoCT), a growing network of computers, mobile devices, online resources, software suites, laboratory equipment, synthesis apparatus, analytical devices, and a host of other machines, all interconnected to users, manufacturers, and others through the infrastructure of the Internet, is changing how we do chemistry. While in its infancy across many chemistry laboratories and departments, it became apparent when considering our own work synthesizing radiopharmaceuticals for positron emission tomography (PET) that a more mature incarnation of the IoCT already exists. Finally, how does the IoCT impact our lives today, and what does it hold for the smartmore » (radio)chemical laboratories of the future?« less

Version 1.00 programmer`s tools used in constructing the INEL RML/analytical radiochemistry sample tracking database and its user interface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Femec, D.A.

This report describes two code-generating tools used to speed design and implementation of relational databases and user interfaces: CREATE-SCHEMA and BUILD-SCREEN. CREATE-SCHEMA produces the SQL commands that actually create and define the database. BUILD-SCREEN takes templates for data entry screens and generates the screen management system routine calls to display the desired screen. Both tools also generate the related FORTRAN declaration statements and precompiled SQL calls. Included with this report is the source code for a number of FORTRAN routines and functions used by the user interface. This code is broadly applicable to a number of different databases.

Nuclear Security Education Program at the Pennsylvania State University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uenlue, Kenan; The Pennsylvania State University, Department of Mechanical and Nuclear Engineering, University Park, PA 16802-2304; Jovanovic, Igor

The availability of trained and qualified nuclear and radiation security experts worldwide has decreased as those with hands-on experience have retired while the demand for these experts and skills have increased. The U.S. Department of Energy's National Nuclear Security Administration's (NNSA) Global Threat Reduction Initiative (GTRI) has responded to the continued loss of technical and policy expertise amongst personnel and students in the security field by initiating the establishment of a Nuclear Security Education Initiative, in partnership with Pennsylvania State University (PSU), Texas A and M (TAMU), and Massachusetts Institute of Technology (MIT). This collaborative, multi-year initiative forms the basismore » of specific education programs designed to educate the next generation of personnel who plan on careers in the nonproliferation and security fields with both domestic and international focus. The three universities worked collaboratively to develop five core courses consistent with the GTRI mission, policies, and practices. These courses are the following: Global Nuclear Security Policies, Detectors and Source Technologies, Applications of Detectors/Sensors/Sources for Radiation Detection and Measurements Nuclear Security Laboratory, Threat Analysis and Assessment, and Design and Analysis of Security Systems for Nuclear and Radiological Facilities. The Pennsylvania State University (PSU) Nuclear Engineering Program is a leader in undergraduate and graduate-level nuclear engineering education in the USA. The PSU offers undergraduate and graduate programs in nuclear engineering. The PSU undergraduate program in nuclear engineering is the largest nuclear engineering programs in the USA. The PSU Radiation Science and Engineering Center (RSEC) facilities are being used for most of the nuclear security education program activities. Laboratory space and equipment was made available for this purpose. The RSEC facilities include the Penn State Breazeale Reactor (PSBR), gamma irradiation facilities (in-pool irradiator, dry irradiator, and hot cells), neutron beam laboratory, radiochemistry laboratories, and various radiation detection and measurement laboratories. A new nuclear security education laboratory was created with DOE NNSA- GTRI funds at RSEC. The nuclear security graduate level curriculum enables the PSU to educate and train future nuclear security experts, both within the United States as well as worldwide. The nuclear security education program at Penn State will grant a Master's degree in nuclear security starting fall 2015. The PSU developed two courses: Nuclear Security- Detector And Source Technologies and Nuclear Security- Applications of Detectors/Sensors/Sources for Radiation Detection and Measurements (Laboratory). Course descriptions and course topics of these courses are described briefly: - Nuclear Security - Detector and Source Technologies; - Nuclear Security - Applications of Detectors/Sensors/Sources for Radiation Detection and Measurements Laboratory.« less

(18)F-labeled positron emission tomographic radiopharmaceuticals in oncology: an overview of radiochemistry and mechanisms of tumor localization.

PubMed

Vallabhajosula, Shankar

2007-11-01

Molecular imaging is the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in a living system. At present, positron emission tomography/computed tomography (PET/CT) is one the most rapidly growing areas of medical imaging, with many applications in the clinical management of patients with cancer. Although [(18)F]fluorodeoxyglucose (FDG)-PET/CT imaging provides high specificity and sensitivity in several kinds of cancer and has many applications, it is important to recognize that FDG is not a "specific" radiotracer for imaging malignant disease. Highly "tumor-specific" and "tumor cell signal-specific" PET radiopharmaceuticals are essential to meet the growing demand of radioisotope-based molecular imaging technology. In the last 15 years, many alternative PET tracers have been proposed and evaluated in preclinical and clinical studies to characterize the tumor biology more appropriately. The potential clinical utility of several (18)F-labeled radiotracers (eg, fluoride, FDOPA, FLT, FMISO, FES, and FCH) is being reviewed by several investigators in this issue. An overview of design and development of (18)F-labeled PET radiopharmaceuticals, radiochemistry, and mechanism(s) of tumor cell uptake and localization of radiotracers are presented here. The approval of clinical indications for FDG-PET in the year 2000 by the Food and Drug Administration, based on a review of literature, was a major breakthrough to the rapid incorporation of PET into nuclear medicine practice, particularly in oncology. Approval of a radiopharmaceutical typically involves submission of a "New Drug Application" by a manufacturer or a company clearly documenting 2 major aspects of the drug: (1) manufacturing of PET drug using current good manufacturing practices and (2) the safety and effectiveness of a drug with specific indications. The potential routine clinical utility of (18)F-labeled PET radiopharmaceuticals depends also on regulatory compliance in addition to documentation of potential safety and efficacy by various investigators.

Radiochemistry Lab Decommissioning and Dismantlement. AECL, Chalk River Labs, Ontario, Canada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kenny, Stephen

2008-01-15

Atomic Energy of Canada (AECL) was originally founded in the mid 1940's to perform research in radiation and nuclear areas under the Canadian Defense Department. In the mid 50's The Canadian government embarked on several research and development programs for the development of the Candu Reactor. AECL was initially built as a temporary site and is now faced with many redundant buildings. Prior to 2004 small amounts of Decommissioning work was in progress. Many reasons for deferring decommissioning activities were used with the predominant ones being: 1. Reduction in radiation doses to workers during the final dismantlement, 2. Development ofmore » a long-term solution for the management of radioactive wastes in Canada, 3. Financial constraints presented by the number of facilities shutdown that would require decommissioning funds and the absence of an approved funding strategy. This has led to the development of a comprehensive decommissioning plan that is all inclusive of AECL's current and legacy liabilities. Canada does not have a long-term disposal site; therefore waste minimization becomes the driving factor behind decontamination for decommissioning before and during dismantlement. This decommissioning job was a great learning experience for decommissioning and the associated contractors who worked on this project. Throughout the life of the project there was a constant focus on waste minimization. This focus was constantly in conflict with regulatory compliance primarily with respect to fire regulations and protecting the facility along with adjacent facilities during the decommissioning activities. Discrepancies in historical documents forced the project to treat every space as a contaminated space until proven differently. Decommissioning and dismantlement within an operating site adds to the complexity of the tasks especially when it is being conducted in the heart of the plant. This project was very successful with no lost time accidents in over one hundred thousand hours worked, on schedule and under budget despite some significant changes throughout the decommissioning phases. The actual cost to decommission this building will come in under 9 million dollars vs. an estimated 14.5 million dollars. This paper will cover some of the unique aspects of dismantling a radioactive building that has seen pretty much every element of the periodic table pass through it with the client requirement focused on minimization of radioactive waste volumes.« less

Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: structural investigations and cellular uptake under hypoxia.

PubMed

Alam, Israt S; Arrowsmith, Rory L; Cortezon-Tamarit, Fernando; Twyman, Frazer; Kociok-Köhn, Gabriele; Botchway, Stanley W; Dilworth, Jonathan R; Carroll, Laurence; Aboagye, Eric O; Pascu, Sofia I

2016-01-07

We report the microwave synthesis of several bis(thiosemicarbazones) and the rapid gallium-68 incorporation to give the corresponding metal complexes. These proved kinetically stable under 'cold' and 'hot' biological assays and were investigated using laser scanning confocal microscopy, flow cytometry and radioactive cell retention studies under normoxia and hypoxia. (68)Ga complex retention was found to be 34% higher in hypoxic cells than in normoxic cells over 30 min, further increasing to 53% at 120 min. Our data suggests that this class of gallium complexes show hypoxia selectivity suitable for imaging in living cells and in vivo tests by microPET in nude athymic mice showed that they are excreted within 1 h of their administration.

Positron emission tomography

NASA Astrophysics Data System (ADS)

Yamamoto, Y. Lucas; Thompson, Christopher J.; Diksic, Mirko; Meyer, Ernest; Feindel, William H.

One of the most exciting new technologies introduced in the last 10 yr is positron emission tomography (PET). PET provides quantitative, three-dimensional images for the study of specific biochemical and physiological processes in the human body. This approach is analogous to quantitative in-vivo autoradiography but has the added advantage of permitting non-invasive in vivo studies. PET scanning requires a small cyclotron to produce short-lived positron emitting isotopes such as oxygen-15, carbon-11, nitrogen-13 and fluorine-18. Proper radiochemical facilities and advanced computer equipment are also needed. Most important, PET requires a multidisciplinary scientific team of physicists, radiochemists, mathematicians, biochemists and physicians. This review analyzes the most recent trends in the imaging technology, radiochemistry, methodology and clinical applications of positron emission tomography.

Comparison between Theoretical Calculation and Experimental Results of Excitation Functions for Production of Relevant Biomedical Radionuclides

NASA Astrophysics Data System (ADS)

Menapace, E.; Birattari, C.; Bonardi, M. L.; Groppi, F.; Morzenti, S.; Zona, C.

2005-05-01

The radionuclide production for biomedical applications has been brought up in the years, as a special nuclear application, at INFN LASA Laboratory, particularly in co-operation with the JRC-Ispra of EC. Mainly scientific aspects concerning radiation detection and the relevant instruments, the measurements of excitation functions of the involved nuclear reactions, the requested radiochemistry studies and further applications have been investigated. On the side of the nuclear data evaluations, based on nuclear model calculations and critically selected experimental data, the appropriate competence has been developed at ENEA Division for Advanced Physics Technologies. A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET radiodiagnostics, are investigated. In this work, last revised measurements and model calculations are reviewed for excitation functions of natZn(d,X)64Cu, 66Ga reactions, referring to irradiation experiments at K=38 variable energy Cyclotron of JRC-Ispra. Concerning the reaction data for producing 186gRe and 211At/211gPo (including significant emission spectra) and 210At, most recent and critically selected experimental results are considered and discussed in comparison with model calculations paying special care to pre-equilibrium effects estimate and to the appropriate overall parameterization. Model calculations are presented for 226Ra(p,2n)225Ac reaction, according to the working program of the ongoing IAEA CRP on the matter.

Prototype development of ion exchanging alpha detectors

NASA Astrophysics Data System (ADS)

Krupp, Dominik; Scherer, Ulrich W.

2018-07-01

In contemporary alpha particle spectrometry, the sample preparation is separated from the detection of the radionuclides. The sample preparation itself requires much time and the equipment of a radiochemistry lab. If sample preparation and detection could be combined in one step, a huge time-saving potential becomes available. One way to realize such a combination is described here. The concept was explored by simulations with the well-established computer programs SRIM and AASI. In a proof of concept, the active surface of commercially available alpha detectors was modified with sulfonic acid groups as a well-known type of cation exchanger. It was shown, that in contrast to a pristine detector, a chemically modified detector is able to extract uranium-238 and -234 selectively as uranyl cations onto the detector surface from a diluted [238/234U]uranyl acetate solution. It was possible to measure directly in the sample solution for one week or to prepare the modified detector surfaces within 30 s for measurements in conventional alpha chambers. In either case, the full width at half maximum of the measured spectra was around 100 keV, allowing a clear nuclide identification. After regenerating the cation exchanger surfaces by rinsing with hydrochloric acid the typical uranium spectra had disappeared, proving chemical bonding of the uranium. Due to the large variety of potential functional groups this new way of alpha spectrometry could be beneficial for all fields of alpha particle spectrometry, from environmental analysis, over security measurements to studies of the heaviest elements.

Comparison between Theoretical Calculation and Experimental Results of Excitation Functions for Production of Relevant Biomedical Radionuclides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Menapace, E.; Birattari, C.; Bonardi, M.L.

The radionuclide production for biomedical applications has been brought up in the years, as a special nuclear application, at INFN LASA Laboratory, particularly in co-operation with the JRC-Ispra of EC. Mainly scientific aspects concerning radiation detection and the relevant instruments, the measurements of excitation functions of the involved nuclear reactions, the requested radiochemistry studies and further applications have been investigated. On the side of the nuclear data evaluations, based on nuclear model calculations and critically selected experimental data, the appropriate competence has been developed at ENEA Division for Advanced Physics Technologies. A series of high specific activity accelerator-produced radionuclides inmore » no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET radiodiagnostics, are investigated. In this work, last revised measurements and model calculations are reviewed for excitation functions of natZn(d,X)64Cu, 66Ga reactions, referring to irradiation experiments at K=38 variable energy Cyclotron of JRC-Ispra. Concerning the reaction data for producing 186gRe and 211At/211gPo (including significant emission spectra) and 210At, most recent and critically selected experimental results are considered and discussed in comparison with model calculations paying special care to pre-equilibrium effects estimate and to the appropriate overall parameterization. Model calculations are presented for 226Ra(p,2n)225Ac reaction, according to the working program of the ongoing IAEA CRP on the matter.« less

Communicating Qualitative Risk to a Rural Audience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vandergraaf, T.T.

Although many risk assessment involve complex mathematical models and a thorough understanding, communicating the risk to the general public can present a considerable challenge. Comprehending a 'one-in-a-million' risk some 10 000 years in the future can be a challenge to the average citizen who is surrounded by more imminent dangers and who has, by virtue of their familiarity, become immune to them. A number of years ago, the then Japan Atomic Energy Institute (JAERI) signed a multi-year cooperative agreement with Atomic Energy of Canada, Ltd (AECL) that included a number of self-contained radioisotope diffusion and migration experiments to be performedmore » under in situ geochemical conditions in a specially designed radiochemistry laboratory at a depth of 240 metres in AECL's Underground Research Laboratory (URL) near Lac du Bonnet, Manitoba, Canada. This underground facility has been excavated in a previously undisturbed granite pluton in the Canadian Shield to study various aspects of high-level nuclear waste management. The region has been the home to AECL's Whiteshell Laboratories since the early 1960's and is surrounded by lakes, forests, some agriculture and mining activity. The economy of town, Lac du Bonnet is based on tourism, forestry, mining and agriculture. The relationship between Lac du Bonnet and AECL has generally been good although there have been attempts by a few local citizens, aided by antinuclear activists from Winnipeg, Manitoba's capital, to curtail the operation of the URL. Although the use of radioisotopes was approved by the then-Atomic Energy Control Board, the Canadian regulatory body, maintaining good working relations with the elected officials of the neighbouring communities was essential to the proposed radioisotope migration experiments. One reason for this was that minute quantities of radioisotope solutions needed to be transported over a distance of {approx}25 km between the URL and the Whiteshell Laboratories over public roads. As part of the public affairs program, the author, before his retirement from AECL, presented a comparison between the amounts of radioisotopes used in the migration experiments and those present in commonly used consumer products. This comparison proved to be adequate to gain the trust and support of the neighbouring communities. This trust was maintained by a rigorous communication program between the project manager and representatives of the local communities, environmental and law enforcement agencies. In summary: The need to present an experimental program to non-scientists presented a golden opportunity to relate the qualitative risk of using radioisotopes in a non-traditional environment to that associated with widely used consumer items and medical therapeutic and diagnostic materials. Although the amounts of radioisotopes used in these experiments are orders of magnitude lower than those in the disposal of nuclear wastes, the approach presented here may have merit in bridging the gap between the scientific community and the general public. The success of the approach used became clear when, towards the end of the experimental program, some of the elected officials expressed satisfaction with the extension of the program for new, a five-year, period. (authors)« less

Geochemistry of polymict ureilite EET83309, and a partially-disruptive impact model for ureilite origin

NASA Technical Reports Server (NTRS)

Warren, Paul H.; Kallemeyn, Gregory W.

1989-01-01

Bulk-compositional data for the EET83309 polymict ureilite were obtained using INAA and radiochemistry procedures and electron probe analysis. It was found that the EET83309 has a bulk composition indistinguishable from ordinary ('monomict') ureilites for all elements except light-middle REEs (which are present in much higher concentrations), suggesting that polymict ureilites are mixtures of ordinary ureilites which were mixed on a very small number of parent bodies. Despite the light-REE enrichments, polymict ureilites are nearly devoid of basaltic (Al-rich) material. It is suggested that the missing basalt may have been blown off the parent body by a partially disruptive collision with a large C-rich projectile. This impact model of ureilite origin reconciles many paradoxical aspects of ureilite composition.

Sediment lithology and radiochemistry from the back-barrier environments along the northern Chandeleur Islands, Louisiana—March 2012

USGS Publications Warehouse

Marot, Marci E.; Smith, Christopher G.; Adams, C. Scott; Richwine, Kathryn A.

2017-04-11

Scientists from the U.S. Geological Survey (USGS) St. Petersburg Coastal and Marine Science Center collected a set of 8 sediment cores from the back-barrier environments along the northern Chandeleur Islands, Louisiana, in March 2012. The sampling efforts were part of a larger USGS study to evaluate effects on the geomorphology of the Chandeleur Islands following the construction of an artificial sand berm to reduce oil transport onto federally managed lands. The objective of this study was to evaluate the response of the back-barrier tidal and wetland environments to the berm. This report serves as an archive for sedimentological and radiochemical data derived from the sediment cores. The data described in this report are available for download on the data downloads page.

Click chemistry in the Development of Contrast Agents for Magnetic Resonance Imaging

PubMed Central

Hapuarachchige, Sudath; Artemov, Dmitri

2016-01-01

Click chemistry provides fast, convenient, versatile and reliable chemical reactions that take place between pairs of functional groups of small molecules that can be purified without chromatographic methods. Due to the fast kinetics and low or no elimination of byproducts, click chemistry is a promising approach that is rapidly gaining acceptance in drug discovery, radiochemistry, bioconjugation, and nanoscience applications. Increasing use of click chemistry in synthetic procedures or as a bioconjugation technique in diagnostic imaging is occurring because click reactions are fast, provide a quantitative yield, and produce minimal amount of nontoxic byproducts. This review summarizes the recent application of click chemistry in magnetic resonance imaging and discusses the directions for applying novel click reactions and strategies for further improving MRI performance. PMID:27748712

Summary and Preliminary Interpretation of Tritium and Dissolved Noble Gas Data from Site 300

DOE Office of Scientific and Technical Information (OSTI.GOV)

Visser, A.; Singleton, M.; Madrid, V.

2014-01-29

In October 2013, groundwater samples were collected from 10 wells from Site 300 and analyzed by the Environmental Radiochemistry Laboratory at Lawrence Livermore National Laboratory (LLNL). Groundwater samples were analyzed for groundwater age tracers: tritium, the helium isotope ratio of dissolved helium and the concentrations of dissolved noble gases (Helium, Neon, Argon, Krypton, and Xenon). A subset of the samples was also analyzed for excess nitrogen due to saturated zone denitrification. The age-dating data were used to evaluate the degree to which groundwater at a particular monitoring well was derived from pre-modern and/or modern sources. More specifically, the analyses canmore » be used to determine whether the recharge age of the groundwater beneath the site pre-dates anthropogenic activities at the site.« less

The performance of hafnium and gadolinium self powered neutron detectors in the TREAT reactor

NASA Astrophysics Data System (ADS)

Imel, G. R.; Hart, P. R.

1996-05-01

The use of gadolinium and hafnium self powered neutron detectors in a transient reactor is described in this paper. The detectors were calibrated to the fission rate of U-235 using calibrated fission chambers; the calibration factors were tested in two reactors in steady state and found to be consistent. Calibration of the detectors in transient reactor conditions was done by using uranium wires that were analyzed by radiochemistry techniques to determine total fissions during the transient. This was correlated to the time-integrated current of the detectors during the transient. A temperature correction factor was derived to account for self-shielding effects in the hafnium and gadolinium detectors. The dynamic response of the detectors under transient conditions was studied, and found to be excellent.

Nanoparticles and Radiotracers: Advances toward Radio-Nanomedicine

PubMed Central

Pratt, Edwin C.; Shaffer, Travis M.; Grimm, Jan

2016-01-01

Here, we cover the convergence of radiochemistry for imaging and therapy with advances in nanoparticle (NP) design for biomedical applications. We first explore NP properties relevant for therapy and theranostics and emphasize the need for biocompatibility. We then explore radionuclide-imaging modalities such as Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Cerenkov Luminescence (CL) with examples utilizing radiolabeled NP for imaging. PET and SPECT have served as diagnostic workhorses in the clinic, while preclinical NP design examples of multimodal imaging with radiotracers show promise in imaging and therapy. CL expands the types of radionuclides beyond PET and SPECT tracers to include high-energy electrons (β−) for imaging purposes. These advances in radionanomedicine will be discussed, showing the potential for radiolabeled NPs as theranostic agents. PMID:27006133

Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation

PubMed Central

Kamlet, Adam S.; Neumann, Constanze N.; Lee, Eunsung; Carlin, Stephen M.; Moseley, Christian K.; Stephenson, Nickeisha; Hooker, Jacob M.; Ritter, Tobias

2013-01-01

New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthetic chemistry development to the preparation of radiotracer doses ready for use in human PET imaging is challenging and rare. Here we describe the process of and the successful translation of a modern palladium-mediated fluorination reaction to non-human primate (NHP) baboon PET imaging–an important milestone on the path to human PET imaging. The method, which transforms [18F]fluoride into an electrophilic fluorination reagent, provides access to aryl–18F bonds that would be challenging to synthesize via conventional radiochemistry methods. PMID:23554994

Simple, rapid method for the preparation of isotopically labeled formaldehyde

DOEpatents

Hooker, Jacob Matthew [Port Jefferson, NY; Schonberger, Matthias [Mains, DE; Schieferstein, Hanno [Aabergen, DE; Fowler, Joanna S [Bellport, NY

2011-10-04

Isotopically labeled formaldehyde (*C.sup..sctn.H.sub.2O) is prepared from labeled methyl iodide (*C.sup..sctn.H.sub.3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C.sup..sctn.H.sub.2O with little or no *C isotopic dilution. The simple, efficient production of .sup.11CH.sub.2O is described. The use of the .sup.11CH.sub.2O for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.

The cyclotron laboratory and the RFQ accelerator in Bern

DOE Office of Scientific and Technical Information (OSTI.GOV)

Braccini, S.; Ereditato, A.; Kreslo, I.

2013-07-18

Two proton accelerators have been recently put in operation in Bern: an 18 MeV cyclotron and a 2 MeV RFQ linac. The commercial IBA 18/18 cyclotron, equipped with a specifically conceived 6 m long external beam line ending in a separate bunker, will provide beams for routine 18-F and other PET radioisotope production as well as for novel detector, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. The accelerator is embedded into a complex building hosting two physics laboratories and four Good Manufacturing Practice (GMP) laboratories. This project is the result of a successful collaboration between the Inselspital, the University ofmore » Bern and private investors, aiming at the constitution of a combined medical and research centre able to provide the most cutting-edge technologies in medical imaging and cancer radiation therapy. The cyclotron is complemented by the RFQ with the primary goals of elemental analysis via Particle Induced Gamma Emission (PIGE), and the detection of potentially dangerous materials with high nitrogen content using the Gamma-Resonant Nuclear Absorption (GRNA) technique. In this context, beam instrumentation devices have been developed, in particular an innovative beam profile monitor based on doped silica fibres and a setup for emittance measurements using the pepper-pot technique. On this basis, the establishment of a proton therapy centre on the campus of the Inselspital is in the phase of advanced study.« less

Review of Angiotensin-converting Enzyme Inhibitory Assay: Rapid Method in Drug Discovery of Herbal Plants

PubMed Central

Ahmad, Islamudin; Yanuar, Arry; Mulia, Kamarza; Mun’im, Abdul

2017-01-01

The renin-angiotensin-aldosterone system is a signaling pathway which responsible in the blood pressure regulation. Angiotensin-converting enzyme (ACE) is one of the key elements responsible for the hypertensive mechanism. It converts angiotensin-I to angiotensin-II. The discovery history of the ACE inhibitory activity assay method has been through a long stage for decades and development continues until today. The ACE inhibitory activity has become an effective screening method in the search for new antihypertensive agents from herbal plants. Some of in vitro assay methods were used to examine the activity of ACE inhibitors based on the substrate usage, such as; Cushman and Cheung Method using a substrate hippuryl-histidyl-leucine (HHL), Holmquist method using a substrate furanacryloyl-tripeptide, Elbl and Wagner method using a substrate benzoil-[l-14C] glicyl-L-histidine-L-leucine, Carmel and Yaron method using a substrate o-aminobenzoylglycyl-p-nitrophenylalanilproline, and Lam method using 3-hydroxybutyrylglycyl-glycyl-glycine as substrate. Several different methods to measure the results of enzymatic reactions or separating substrate with products, including spectrophotometric, fluorometric, high-performance liquid chromatography, electrophoresis, and radiochemistry. Application of the test method for screening the ACE inhibitors activity and investigation of active compounds from natural products can be done easily with this method, it is very helpful in research because the results obtained are simple, accurate, and rapid. PMID:28503045

The cyclotron laboratory and the RFQ accelerator in Bern

NASA Astrophysics Data System (ADS)

Braccini, S.; Ereditato, A.; Kreslo, I.; Nirkko, M.; Scampoli, P.; von Bremen, K.; Weber, M.

2013-07-01

Two proton accelerators have been recently put in operation in Bern: an 18 MeV cyclotron and a 2 MeV RFQ linac. The commercial IBA 18/18 cyclotron, equipped with a specifically conceived 6 m long external beam line ending in a separate bunker, will provide beams for routine 18-F and other PET radioisotope production as well as for novel detector, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. The accelerator is embedded into a complex building hosting two physics laboratories and four Good Manufacturing Practice (GMP) laboratories. This project is the result of a successful collaboration between the Inselspital, the University of Bern and private investors, aiming at the constitution of a combined medical and research centre able to provide the most cutting-edge technologies in medical imaging and cancer radiation therapy. The cyclotron is complemented by the RFQ with the primary goals of elemental analysis via Particle Induced Gamma Emission (PIGE), and the detection of potentially dangerous materials with high nitrogen content using the Gamma-Resonant Nuclear Absorption (GRNA) technique. In this context, beam instrumentation devices have been developed, in particular an innovative beam profile monitor based on doped silica fibres and a setup for emittance measurements using the pepper-pot technique. On this basis, the establishment of a proton therapy centre on the campus of the Inselspital is in the phase of advanced study.

Comprehensive Glossary of Nuclear Science

NASA Astrophysics Data System (ADS)

Langlands, Tracy; Stone, Craig; Meyer, Richard

2001-10-01

We have developed a comprehensive glossary of terms covering the broad fields of nuclear and related areas of science. The glossary has been constructed with two sections. A primary section consists of over 6,000 terms covering the fields of nuclear and high energy physics, nuclear chemistry, radiochemistry, health physics, astrophysics, materials science, analytical science, environmental science, nuclear medicine, nuclear engineering, nuclear instrumentation, nuclear weapons, and nuclear safeguards. Approximately 1,500 terms of specific focus on military and nuclear weapons testing define the second section. The glossary is currently larger than many published glossaries and dictionaries covering the entire field of physics. Glossary terms have been defined using an extensive collection of current and historical publications. Historical texts extend back into the 1800's, the early days of atomic physics. The glossary has been developed both as a software application and as a hard copy document.

Integral cross section measurement of the U 235 ( n , n ' ) U 235 m reaction in a pulsed reactor

DOE PAGES

Bélier, G.; Bond, E. M.; Vieira, D. J.; ...

2015-04-08

The integral measurement of the neutron inelastic cross section leading to the 26-minute half-life 235mU isomer in a fission-like neutron spectrum is presented. The experiment has been performed at a pulsed reactor, where the internal conversion decay of the isomer was measured using a dedicated electron detector after activation. The sample preparation, efficiency measurement, irradiation, radiochemistry purification, and isomer decay measurement will be presented. We determined the integral cross section for the ²³⁵U(n,n') 235mU reaction to be 1.00±0.13b. This result supports an evaluation performed with TALYS-1.4 code with respect to the isomer excitation as well as the total neutron inelasticmore » scattering cross section.« less

Glycine formation in CO2:CH4:NH3 ices induced by 0-70 eV electrons

NASA Astrophysics Data System (ADS)

Esmaili, Sasan; Bass, Andrew D.; Cloutier, Pierre; Sanche, Léon; Huels, Michael A.

2018-04-01

Glycine (Gly), the simplest amino-acid building-block of proteins, has been identified on icy dust grains in the interstellar medium, icy comets, and ice covered meteorites. These astrophysical ices contain simple molecules (e.g., CO2, H2O, CH4, HCN, and NH3) and are exposed to complex radiation fields, e.g., UV, γ, or X-rays, stellar/solar wind particles, or cosmic rays. While much current effort is focused on understanding the radiochemistry induced in these ices by high energy radiation, the effects of the abundant secondary low energy electrons (LEEs) it produces have been mostly assumed rather than studied. Here we present the results for the exposure of multilayer CO2:CH4:NH3 ice mixtures to 0-70 eV electrons under simulated astrophysical conditions. Mass selected temperature programmed desorption (TPD) of our electron irradiated films reveals multiple products, most notably intact glycine, which is supported by control measurements of both irradiated or un-irradiated binary mixture films, and un-irradiated CO2:CH4:NH3 ices spiked with Gly. The threshold of Gly formation by LEEs is near 9 eV, while the TPD analysis of Gly film growth allows us to determine the "quantum" yield for 70 eV electrons to be about 0.004 Gly per incident electron. Our results show that simple amino acids can be formed directly from simple molecular ingredients, none of which possess preformed C—C or C—N bonds, by the copious secondary LEEs that are generated by ionizing radiation in astrophysical ices.

Glycine formation in CO2:CH4:NH3 ices induced by 0-70 eV electrons.

PubMed

Esmaili, Sasan; Bass, Andrew D; Cloutier, Pierre; Sanche, Léon; Huels, Michael A

2018-04-28

Glycine (Gly), the simplest amino-acid building-block of proteins, has been identified on icy dust grains in the interstellar medium, icy comets, and ice covered meteorites. These astrophysical ices contain simple molecules (e.g., CO 2 , H 2 O, CH 4 , HCN, and NH 3 ) and are exposed to complex radiation fields, e.g., UV, γ, or X-rays, stellar/solar wind particles, or cosmic rays. While much current effort is focused on understanding the radiochemistry induced in these ices by high energy radiation, the effects of the abundant secondary low energy electrons (LEEs) it produces have been mostly assumed rather than studied. Here we present the results for the exposure of multilayer CO 2 :CH 4 :NH 3 ice mixtures to 0-70 eV electrons under simulated astrophysical conditions. Mass selected temperature programmed desorption (TPD) of our electron irradiated films reveals multiple products, most notably intact glycine, which is supported by control measurements of both irradiated or un-irradiated binary mixture films, and un-irradiated CO 2 :CH 4 :NH 3 ices spiked with Gly. The threshold of Gly formation by LEEs is near 9 eV, while the TPD analysis of Gly film growth allows us to determine the "quantum" yield for 70 eV electrons to be about 0.004 Gly per incident electron. Our results show that simple amino acids can be formed directly from simple molecular ingredients, none of which possess preformed C-C or C-N bonds, by the copious secondary LEEs that are generated by ionizing radiation in astrophysical ices.

Dose rate prediction methodology for remote handled transuranic waste workers at the waste isolation pilot plant.

PubMed

Hayes, Robert

2002-10-01

An approach is described for estimating future dose rates to Waste Isolation Pilot Plant workers processing remote handled transuranic waste. The waste streams will come from the entire U.S. Department of Energy complex and can take on virtually any form found from the processing sequences for defense-related production, radiochemistry, activation and related work. For this reason, the average waste matrix from all generator sites is used to estimate the average radiation fields over the facility lifetime. Innovative new techniques were applied to estimate expected radiation fields. Non-linear curve fitting techniques were used to predict exposure rate profiles from cylindrical sources using closed form equations for lines and disks. This information becomes the basis for Safety Analysis Report dose rate estimates and for present and future ALARA design reviews when attempts are made to reduce worker doses.

Consensus nomenclature rules for radiopharmaceutical chemistry — Setting the record straight

DOE PAGES

Coenen, Heinz H.; Gee, Antony D.; Adam, Michael; ...

2017-10-21

Over recent years, within the community of radiopharmaceutical sciences, there has been an increased incidence of incorrect usage of established scientific terms and conventions, and even the emergence of ‘self-invented’ terms. Here, in order to address these concerns, an international Working Group on ‘Nomenclature in Radiopharmaceutical Chemistry and related areas’ was established in 2015 to achieve clarification of terms and to generate consensus on the utilisation of a standardised nomenclature pertinent to the field. Upon open consultation, the following consensus guidelines were agreed, which aim to: Provide a reference source for nomenclature good practice in the radiopharma-ceutical sciences; Clarify themore » use of terms and rules concerning exclusively radiopharmaceutical terminology, i.e. nuclear- and radiochemical terms, symbols and expressions; Address gaps and inconsistencies in existing radiochemistry nomenclature rules; Provide source literature for further harmonisation beyond our immediate peer group (publishers, editors, IUPAC, pharmacopoeias, etc.).« less

Molecular Imaging Probe Development using Microfluidics

PubMed Central

Liu, Kan; Wang, Ming-Wei; Lin, Wei-Yu; Phung, Duy Linh; Girgis, Mark D.; Wu, Anna M.; Tomlinson, James S.; Shen, Clifton K.-F.

2012-01-01

In this manuscript, we review the latest advancement of microfluidics in molecular imaging probe development. Due to increasing needs for medical imaging, high demand for many types of molecular imaging probes will have to be met by exploiting novel chemistry/radiochemistry and engineering technologies to improve the production and development of suitable probes. The microfluidic-based probe synthesis is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional systems. Numerous chemical reactions have been successfully performed in micro-reactors and the results convincingly demonstrate with great benefits to aid synthetic procedures, such as purer products, higher yields, shorter reaction times compared to the corresponding batch/macroscale reactions, and more benign reaction conditions. Several ‘proof-of-principle’ examples of molecular imaging probe syntheses using microfluidics, along with basics of device architecture and operation, and their potential limitations are discussed here. PMID:22977436

Excreta Sampling as an Alternative to In Vivo Measurements at the Hanford Site.

PubMed

Carbaugh, Eugene H; Antonio, Cheryl L; Lynch, Timothy P

2015-08-01

The capabilities of indirect radiobioassay by urine and fecal sample analysis were compared with the direct radiobioassay methods of whole body counting and lung counting for the most common radionuclides and inhalation exposure scenarios encountered by Hanford workers. Radionuclides addressed by in vivo measurement included 137Cs, 60Co, 154Eu, and 241Am as an indicator for plutonium mixtures. The same radionuclides were addressed using gamma energy analysis of urine samples, augmented by radiochemistry and alpha spectrometry methods for plutonium in urine and fecal samples. It was concluded that in vivo whole body counting and lung counting capability should be maintained at the Hanford Site for the foreseeable future, however, urine and fecal sample analysis could provide adequate, though degraded, monitoring capability for workers as a short-term alternative, should in vivo capability be lost due to planned or unplanned circumstances.

Radiochemistry of iodine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kahn, M.; Kleinberg, J.

1977-09-01

The preparation of isotopes of the element, with selected procedures for its determination in or separation from various media is described along with the separating of iodine species from each other. Each part of the introductory section is referenced separately from the remainder of the monograph. For the preparative and analytical sections there is an extensive, indexed bibliography which was developed from the indexes of Volumes 19 to 30 inclusive (1965-1974) of Nuclear Science Abstracts (NSA). From these indexes the NSA abstracts of possible pertinent references were selected for examination and a choice was made of those references which weremore » to be included in the bibliography. The bibliography has both primary and secondary references. Although the monograph does not cover hot atom chemistry, the kinetics of exchange reactions, decay schemes, or physiological applications, papers in these areas were examined as possible sources of useful preparative and analytical procedures. (JRD)« less

Targeted and Nontargeted α-Particle Therapies.

PubMed

McDevitt, Michael R; Sgouros, George; Sofou, Stavroula

2018-06-04

α-Particle irradiation of cancerous tissue is increasingly recognized as a potent therapeutic option. We briefly review the physics, radiobiology, and dosimetry of α-particle emitters, as well as the distinguishing features that make them unique for radiopharmaceutical therapy. We also review the emerging clinical role of α-particle therapy in managing cancer and recent studies on in vitro and preclinical α-particle therapy delivered by antibodies, other small molecules, and nanometer-sized particles. In addition to their unique radiopharmaceutical characteristics, the increased availability and improved radiochemistry of α-particle radionuclides have contributed to the growing recent interest in α-particle radiotherapy. Targeted therapy strategies have presented novel possibilities for the use of α-particles in the treatment of cancer. Clinical experience has already demonstrated the safe and effective use of α-particle emitters as potent tumor-selective drugs for the treatment of leukemia and metastatic disease.

Targeted and Nontargeted α-Particle Therapies

PubMed Central

McDevitt, Michael R.; Sgouros, George; Sofou, Stavroula

2018-01-01

α-Particle irradiation of cancerous tissue is increasingly recognized as a potent therapeutic option. We briefly review the physics, radiobiology, and dosimetry of α-particle emitters, as well as the distinguishing features that make them unique for radiopharmaceutical therapy. We also review the emerging clinical role of α-particle therapy in managing cancer and recent studies on in vitro and preclinical α-particle therapy delivered by antibodies, other small molecules, and nanometer-sized particles. In addition to their unique radiopharmaceutical characteristics, the increased availability and improved radiochemistry of α-particle radionuclides have contributed to the growing recent interest in α-particle radiotherapy. Targeted therapy strategies have presented novel possibilities for the use of α-particles in the treatment of cancer. Clinical experience has already demonstrated the safe and effective use of α-particle emitters as potent tumor-selective drugs for the treatment of leukemia and metastatic disease. PMID:29345977

Consensus nomenclature rules for radiopharmaceutical chemistry — Setting the record straight

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coenen, Heinz H.; Gee, Antony D.; Adam, Michael

Over recent years, within the community of radiopharmaceutical sciences, there has been an increased incidence of incorrect usage of established scientific terms and conventions, and even the emergence of ‘self-invented’ terms. Here, in order to address these concerns, an international Working Group on ‘Nomenclature in Radiopharmaceutical Chemistry and related areas’ was established in 2015 to achieve clarification of terms and to generate consensus on the utilisation of a standardised nomenclature pertinent to the field. Upon open consultation, the following consensus guidelines were agreed, which aim to: Provide a reference source for nomenclature good practice in the radiopharma-ceutical sciences; Clarify themore » use of terms and rules concerning exclusively radiopharmaceutical terminology, i.e. nuclear- and radiochemical terms, symbols and expressions; Address gaps and inconsistencies in existing radiochemistry nomenclature rules; Provide source literature for further harmonisation beyond our immediate peer group (publishers, editors, IUPAC, pharmacopoeias, etc.).« less

A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging

PubMed Central

2015-01-01

A new 18F-labeled tetrazine derivative was developed aiming at optimal radiochemistry, fast reaction kinetics in inverse electron-demand Diels–Alder cycloaddition (IEDDA), and favorable pharmacokinetics for in vivo bioorthogonal chemistry. The radiolabeling of the tetrazine was achieved in high yield, purity, and specific activity under mild reaction conditions via conjugation with 5-[18F]fluoro-5-deoxyribose, providing a glycosylated tetrazine derivative with low lipophilicity. The 18F-tetrazine showed fast reaction kinetics toward the most commonly used dienophiles in IEDDA reactions. It exhibited excellent chemical and enzymatic stability in mouse plasma and in phosphate-buffered saline (pH 7.41). Biodistribution in mice revealed favorable pharmacokinetics with major elimination via urinary excretion. The results indicate that the glycosylated 18F-labeled tetrazine is an excellent candidate for in vivo bioorthogonal chemistry applications in pretargeted PET imaging approaches. PMID:26819667

Response of Microbial Community Function to Fluctuating Geochemical Conditions within a Legacy Radioactive Waste Trench Environment

PubMed Central

Kinsela, Andrew S.; Bligh, Mark W.; Harrison, Jennifer J.; Payne, Timothy E.

2017-01-01

ABSTRACT During the 1960s, small quantities of radioactive materials were codisposed with chemical waste at the Little Forest Legacy Site (Sydney, Australia) in 3-meter-deep, unlined trenches. Chemical and microbial analyses, including functional and taxonomic information derived from shotgun metagenomics, were collected across a 6-week period immediately after a prolonged rainfall event to assess the impact of changing water levels upon the microbial ecology and contaminant mobility. Collectively, results demonstrated that oxygen-laden rainwater rapidly altered the redox balance in the trench water, strongly impacting microbial functioning as well as the radiochemistry. Two contaminants of concern, plutonium and americium, were shown to transition from solid-iron-associated species immediately after the initial rainwater pulse to progressively more soluble moieties as reducing conditions were enhanced. Functional metagenomics revealed the potentially important role that the taxonomically diverse microbial community played in this transition. In particular, aerobes dominated in the first day, followed by an increase of facultative anaerobes/denitrifiers at day 4. Toward the mid-end of the sampling period, the functional and taxonomic profiles depicted an anaerobic community distinguished by a higher representation of dissimilatory sulfate reduction and methanogenesis pathways. Our results have important implications to similar near-surface environmental systems in which redox cycling occurs. IMPORTANCE The role of chemical and microbiological factors in mediating the biogeochemistry of groundwaters from trenches used to dispose of radioactive materials during the 1960s is examined in this study. Specifically, chemical and microbial analyses, including functional and taxonomic information derived from shotgun metagenomics, were collected across a 6-week period immediately after a prolonged rainfall event to assess how changing water levels influence microbial ecology and contaminant mobility. Results demonstrate that oxygen-laden rainwater rapidly altered the redox balance in the trench water, strongly impacting microbial functioning as well as the radiochemistry. Two contaminants of concern, plutonium and americium, were shown to transition from solid-iron-associated species immediately after the initial rainwater pulse to progressively more soluble moieties as reducing conditions were enhanced. Functional metagenomics revealed the important role that the taxonomically diverse microbial community played in this transition. Our results have important implications to similar near-surface environmental systems in which redox cycling occurs. PMID:28667104

Response of Microbial Community Function to Fluctuating Geochemical Conditions within a Legacy Radioactive Waste Trench Environment.

PubMed

Vázquez-Campos, Xabier; Kinsela, Andrew S; Bligh, Mark W; Harrison, Jennifer J; Payne, Timothy E; Waite, T David

2017-09-01

During the 1960s, small quantities of radioactive materials were codisposed with chemical waste at the Little Forest Legacy Site (Sydney, Australia) in 3-meter-deep, unlined trenches. Chemical and microbial analyses, including functional and taxonomic information derived from shotgun metagenomics, were collected across a 6-week period immediately after a prolonged rainfall event to assess the impact of changing water levels upon the microbial ecology and contaminant mobility. Collectively, results demonstrated that oxygen-laden rainwater rapidly altered the redox balance in the trench water, strongly impacting microbial functioning as well as the radiochemistry. Two contaminants of concern, plutonium and americium, were shown to transition from solid-iron-associated species immediately after the initial rainwater pulse to progressively more soluble moieties as reducing conditions were enhanced. Functional metagenomics revealed the potentially important role that the taxonomically diverse microbial community played in this transition. In particular, aerobes dominated in the first day, followed by an increase of facultative anaerobes/denitrifiers at day 4. Toward the mid-end of the sampling period, the functional and taxonomic profiles depicted an anaerobic community distinguished by a higher representation of dissimilatory sulfate reduction and methanogenesis pathways. Our results have important implications to similar near-surface environmental systems in which redox cycling occurs. IMPORTANCE The role of chemical and microbiological factors in mediating the biogeochemistry of groundwaters from trenches used to dispose of radioactive materials during the 1960s is examined in this study. Specifically, chemical and microbial analyses, including functional and taxonomic information derived from shotgun metagenomics, were collected across a 6-week period immediately after a prolonged rainfall event to assess how changing water levels influence microbial ecology and contaminant mobility. Results demonstrate that oxygen-laden rainwater rapidly altered the redox balance in the trench water, strongly impacting microbial functioning as well as the radiochemistry. Two contaminants of concern, plutonium and americium, were shown to transition from solid-iron-associated species immediately after the initial rainwater pulse to progressively more soluble moieties as reducing conditions were enhanced. Functional metagenomics revealed the important role that the taxonomically diverse microbial community played in this transition. Our results have important implications to similar near-surface environmental systems in which redox cycling occurs. Copyright © 2017 Vázquez-Campos et al.

Formerly utilized MED/AEC sites remedial action program. Radiological survey of The George Herbert Jones Chemical Laboratory, The University of Chicago, Chicago, Illinois, June 13-17, 1977

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wynveen, R.A.; Smith, W.H.; Mayes, C.B.

A comprehensive radiological survey was conducted at George Herbert Jones Chemical Laboratory at the University of Chicago, Chicago, Illinois. Radiochemistry for the MED/AEC project was performed in this building in the 1940s. The building is now used as laboratories, offices, and classrooms. The survey was undertaken to determine the location and quantities of any radioactive materials remaining from the MED/AEC operations. Forty-three spots of contamination possibly resulting from MED/AEC occupancy in 17 rooms exceeded the allowable limits as given in the ANSI Standard N13.12. Under current use conditions, the potential for radiation exposure to occupants of this building from thesemore » sources of contamination is remote. Concentrations of radon daughters in the air of the building, as measured with grab-sampling techniques, were below the limit of 0.01 WL above background as given in the Surgeon General's Guidelines. No long-lived radionuclides were detected in any air sample. Concentrations of radionuclides in soil samples from near the laboratory generally indicated background levels. In order to reduce the potential for radiation exposure, remedial measures such as stabilization of the contamination in place would be applicable as a short-term measure. In order to reduce the risk in the event that building modifications take place in the future, health physics procedures and coverage are recommended. The long-term solution would involve decontamination by removal of the radioactive residues from the 17 rooms or areas where contamination possibly resulting from MED/AEC activities was detected.« less

Determination of the Spectral Index in the Fission Spectrum Energy Regime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Amy Sarah

2016-05-16

Neutron reaction cross sections play a vital role in tracking the production and destruction of isotopes exposed to neutron fluence. They are central to the process of reconciling the initial and final atom inventories. Measurements of irradiated samples by radiochemical methods in tangent with an algorithm are used to evaluate the fluence a sample is exposed to over the course of the irradiation. This algorithm is the Isotope Production Code (IPC) created and used by the radiochemistry data assessment team at Los Alamos National Laboratory (LANL). An integral result is calculated by varying the total neutron fluence seen by amore » sample. A sample, irradiated in a critical assembly, will be exposed to a unique neutron flux defined by the neutron source and distance of the sample from the source. Neutron cross sections utilized are a function of the hardness of the neutron spectrum at the location of irradiation. A spectral index is used an indicator of the hardness of the neutron spectrum. Cross sections fit forms applied in IPC are collapsed from a LANL 30-group energy structure. Several decades of research and development have been performed to formalize the current IPC cross section library. Basis of the current fission spectrum neutron reaction cross section library is rooted in critical assembly experiments performed from the 1950’s through the early 1970’s at LANL. The focus of this report is development of the spectral index used an indicator of the hardness of the neutron spectrum in the fission spectrum energy regime.« less

Results and Analysis of the Infrastructure Request for Information (DE-SOL-0008318)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heidrich, Brenden John

2015-07-01

The Department of Energy (DOE) Office of Nuclear Energy (NE) released a request for information (RFI) (DE-SOL-0008318) for “University, National Laboratory, Industry and International Input on Potential Office of Nuclear Energy Infrastructure Investments” on April 13, 2015. DOE-NE solicited information on five specific types of capabilities as well as any others suggested by the community. The RFI proposal period closed on June 19, 2015. From the 26 responses, 34 individual proposals were extracted. Eighteen were associated with a DOE national laboratory, including Argonne National Laboratory (ANL), Brookhaven National Laboratory (BNL), Idaho National Laboratory (INL), Los Alamos National Laboratory (LANL), Pacificmore » Northwest National Laboratory (PNNL) and Sandia National Laboratory (SNL). Oak Ridge National Laboratory (ORNL) was referenced in a proposal as a proposed capability location, although the proposal did not originate with ORNL. Five US universities submitted proposals (Massachusetts Institute of Technology, Pennsylvania State University, Rensselaer Polytechnic Institute, University of Houston and the University of Michigan). Three industrial/commercial institutions submitted proposals (AREVA NP, Babcock and Wilcox (B&W) and the Electric Power Research Institute (EPRI)). Eight major themes emerged from the submissions as areas needing additional capability or support for existing capabilities. Two submissions supported multiple areas. The major themes are: Advanced Manufacturing (AM), High Performance Computing (HPC), Ion Irradiation with X-Ray Diagnostics (IIX), Ion Irradiation with TEM Visualization (IIT), Radiochemistry Laboratories (RCL), Test Reactors, Neutron Sources and Critical Facilities (RX) , Sample Preparation and Post-Irradiation Examination (PIE) and Thermal-Hydraulics Test Facilities (THF).« less

Production of Astatine-211 at the Duke University Medical Center for its regional distribution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zalutsky, Michael

Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that accessmore » to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.« less

SWEIS Yearbook-2012 Comparison of 2012 Data to Projections of the 2008 Site-Wide Environmental Impact Statement for Continued Operation of Los Alamos National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahowald, Hallie B.; Wright, Marjorie Alys

2014-01-16

Los Alamos National Laboratory (LANL or the Laboratory) operations data for Calendar Year (CY) 2012 mostly fell within the 2008 Site-Wide Environmental Impact Statement (SWEIS) projections. Operation levels for one LANL facility exceeded the 2008 SWEIS capability projections—Radiochemistry Facility; however, none of the capability increases caused exceedances in radioactive air emissions, waste generation, or National Pollutant Discharge Elimination System (NPDES) discharge. Several facilities exceeded the2008 SWEIS levels for waste generation quantities; however, all were one-time, non-routine events that do not reflect the day-to-day operations of the Laboratory. In addition, total site-wide waste generation quantities were below SWEIS projections for allmore » waste types, reflecting the overall levels of operations at both the Key and Non-Key Facilities. Although gas and electricity consumption have remained within the 2008 SWEIS limits for utilities, water consumption exceeded the 2008 SWEIS projections by 27 million gallons in CY 2012.« less

Calibration and operational data for a compact photodiode detector useful for monitoring the location of moving sources of positron emitting radioisotopes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marsland, M. G.; Dehnel, M. P.; Theroux, J.

2013-04-19

D-Pace has developed a compact cost-effective gamma detector system based on technology licensed from TRIUMF. These photodiode detectors are convenient for detecting the presence of positron emitting radioisotopes, particularly for the case of transport of radioisotopes from a PET cyclotron to hotlab, or from one location to another in an automated radiochemistry processing unit. This paper describes recent calibration experiments undertaken at the Turku PET Centre for stationary and moving sources of F18 and C11 in standard setups. The practical diagnostic utility of using several of these devices to track the transport of radioisotopes from the cyclotron to hotlab ismore » illustrated. For example, such a detector system provides: a semi-quantitative indication of total activity, speed of transport, location of any activity lost en route and effectiveness of follow-up system flushes, a means of identifying bolus break-up, feedback useful for deciding when to change out tubing.« less

Biological shielding test of hot cells with high active source 60Co (300 TBq)

NASA Astrophysics Data System (ADS)

Švrčula, P.; Zoul, D.; Zimina, M.; Petříčková, A.; Adamíková, T.; Schulc, M.; Srba, O.

2017-11-01

This article describes a method for testing of the efficiency of the biological shielding of the hot cell facility, which were constructed as a part of the project SUSEN. Ten hot cells and one semi-hot cell are present in the facility Radiochemistry II. The shielding is made from steel plates. In order to demonstrate sufficient efficiency of the biological shielding of the hot cells and a correspondence between measured and contractual values at selected points. The test was done using sealed high activity 60Co sources. The results are also used as a proof of the optimization of radiation protection for the workplace of this type. The results confirm significant optimization of radiation protection at the workplace. The dose received by a staff do not exceed one tens of annual limit during active service. Obtained results fulfill general requirements of radiation protection and will be used for further active service of hot cells facility.

Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: structural investigations and cellular uptake under hypoxia† †Electronic supplementary information (ESI) available. CCDC 1001632–1001634. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5dt02537k Click here for additional data file. Click here for additional data file.

PubMed Central

Alam, Israt S.; Arrowsmith, Rory L.; Cortezon-Tamarit, Fernando; Twyman, Frazer; Kociok-Köhn, Gabriele; Botchway, Stanley W.; Dilworth, Jonathan R.

2016-01-01

We report the microwave synthesis of several bis(thiosemicarbazones) and the rapid gallium-68 incorporation to give the corresponding metal complexes. These proved kinetically stable under ‘cold’ and ‘hot’ biological assays and were investigated using laser scanning confocal microscopy, flow cytometry and radioactive cell retention studies under normoxia and hypoxia. 68Ga complex retention was found to be 34% higher in hypoxic cells than in normoxic cells over 30 min, further increasing to 53% at 120 min. Our data suggests that this class of gallium complexes show hypoxia selectivity suitable for imaging in living cells and in vivo tests by microPET in nude athymic mice showed that they are excreted within 1 h of their administration. PMID:26583314

Radioactivity in trinitite six decades later.

PubMed

Parekh, Pravin P; Semkow, Thomas M; Torres, Miguel A; Haines, Douglas K; Cooper, Joseph M; Rosenberg, Peter M; Kitto, Michael E

2006-01-01

The first nuclear explosion test, named the Trinity test, was conducted on July 16, 1945 near Alamogordo, New Mexico. In the tremendous heat of the explosion, the radioactive debris fused with the local soil into a glassy material named Trinitite. Selected Trinitite samples from ground zero (GZ) of the test site were investigated in detail for radioactivity. The techniques used included alpha spectrometry, high-efficiency gamma-ray spectrometry, and low-background beta counting, following the radiochemistry for selected radionuclides. Specific activities were determined for fission products (90Sr, 137Cs), activation products (60Co, 133Ba, 152Eu, 154Eu, 238Pu, 241Pu), and the remnants of the nuclear fuel (239Pu, 240Pu). Additionally, specific activities of three natural radionuclides (40K, 232Th, 238U) and their progeny were measured. The determined specific activities of radionuclides and their relationships are interpreted in the context of the fission process, chemical behavior of the elements, as well as the nuclear explosion phenomenology.

A broadly applicable [18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging

NASA Astrophysics Data System (ADS)

Huiban, Mickael; Tredwell, Matthew; Mizuta, Satoshi; Wan, Zehong; Zhang, Xiaomin; Collier, Thomas Lee; Gouverneur, Véronique; Passchier, Jan

2013-11-01

Molecules labelled with the unnatural isotope fluorine-18 are used for positron emission tomography. Currently, this molecular imaging technology is not exploited at its full potential because many 18F-labelled probes are inaccessible or notoriously difficult to produce. Typical challenges associated with 18F radiochemistry are the short half-life of 18F (<2 h), the use of sub-stoichiometric amounts of 18F, relative to the precursor and other reagents, as well as the limited availability of parent 18F sources of suitable reactivity ([18F]F- and [18F]F2). There is a high-priority demand for general methods allowing access to [18F]CF3-substituted molecules for application in pharmaceutical discovery programmes. We report the development of a process for the late-stage [18F]trifluoromethylation of (hetero)arenes from [18F]fluoride using commercially available reagents and (hetero)aryl iodides. This [18F]CuCF3-based protocol benefits from a large substrate scope and is characterized by its operational simplicity.

Quantifying Sediment Characteristics and Infilling Rate within a Ship Shoal Dredge Borrow Area, Offshore Louisiana

NASA Astrophysics Data System (ADS)

Xue, Z.; Wilson, C.; Bentley, S. J.; Xu, K.; Liu, H.; Li, C.; Miner, M. D.

2017-12-01

Barrier islands provide protection to interior wetlands and maintain estuarine gradients. Mississippi River delta plain barrier islands are undergoing rapid disintegration due to high rates of subsidence and a deficit in the coastal sand supply. To mitigate for barrier island land loss, Louisiana has implemented a restoration program that intends to supplement coastal sand deficits by introducing sand from outside of the active coastal system. Inner-shelf shoals offshore Louisiana are one of the only sand resource options containing large volumes of restoration quality sand. Ship Shoal is one of these inner-shelf shoals that was produced by marine reworking of former Mississippi River Delta barrier island sediments during late Holocene time. Though indirect effects to protected areas or infrastructure adjacent to excavations have been considered, there is a paucity of observational data on their evolution. Caminada borrow area, dredged in 2013-2016 for the Caminada Headland Restoration Project, provides a valuable opportunity to validate and improve predictive models for how borrow areas evolve. In July 2017, a subbottom and bathymetric geophysical survey was conducted and sediment cores were collected to test the hypothesis that sedimentation within the excavation is affected by lateral bedload transport after initial rapid infill as slopes equilibrate. Preliminary results show the sediment within the excavation is predominantly very fine sand with isolated mud drapes. These sediments overlay older delta complex muddy strata. This contrasts strongly with other dredge pits outside of shoal areas and closer to shore, which have been infilled largely by advection of fine suspended sediments of fluvial origin. Laboratory work on cores will include laser grain size, x-ray analyses of sedimentary structures, and radiochemistry analyses for rates and age of deposition. With the knowledge of stratigraphy and sediment dynamics surrounding the dredge pit, we can quantify and better understand the timeline of these depositional processes to provide vital knowledge to coastal managers for future borrow area design and management.

5 CFR 470.201 - Purposes of research programs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Purposes of research programs. 470.201... PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.201 Purposes of research programs. The purposes of research programs undertaken...

5 CFR 470.201 - Purposes of research programs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Purposes of research programs. 470.201... PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.201 Purposes of research programs. The purposes of research programs undertaken...

Gold Nanoparticles Doped with (199) Au Atoms and Their Use for Targeted Cancer Imaging by SPECT.

PubMed

Zhao, Yongfeng; Pang, Bo; Luehmann, Hannah; Detering, Lisa; Yang, Xuan; Sultan, Deborah; Harpstrite, Scott; Sharma, Vijay; Cutler, Cathy S; Xia, Younan; Liu, Yongjian

2016-04-20

Gold nanoparticles have been labeled with various radionuclides and extensively explored for single photon emission computed tomography (SPECT) in the context of cancer diagnosis. The stability of most radiolabels, however, still needs to be improved for accurate detection of cancer biomarkers and thereby monitoring of tumor progression and metastasis. Here, the first synthesis of Au nanoparticles doped with (199)Au atoms for targeted SPECT tumor imaging in a mouse triple negative breast cancer (TNBC) model is reported. By directly incorporating (199)Au atoms into the crystal lattice of each Au nanoparticle, the stability of the radiolabel can be ensured. The synthetic procedure also allows for a precise control over both the radiochemistry and particle size. When conjugated with D-Ala1-peptide T-amide, the Au nanoparticles doped with (199)Au atoms can serve as a C-C chemokine receptor 5 (CCR5)-targeted nanoprobe for the sensitive and specific detection of both TNBC and its metastasis in a mouse tumor model. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Final Report 2007: DOE-FG02-87ER60561

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kilbourn, Michael R

2007-04-26

This project involved a multi-faceted approach to the improvement of techniques used in Positron Emission Tomography (PET), from radiochemistry to image processing and data analysis. New methods for radiochemical syntheses were examined, new radiochemicals prepared for evaluation and eventual use in human PET studies, and new pre-clinical methods examined for validation of biochemical parameters in animal studies. The value of small animal PET imaging in measuring small changes of in vivo biochemistry was examined and directly compared to traditional tissue sampling techniques. In human imaging studies, the ability to perform single experimental sessions utilizing two overlapping injections of radiopharmaceuticals wasmore » tested, and it was shown that valid biochemical measures for both radiotracers can be obtained through careful pharmacokinetic modeling of the PET emission data. Finally, improvements in reconstruction algorithms for PET data from small animal PET scanners was realized and these have been implemented in commercial releases. Together, the project represented an integrated effort to improve and extend all basic science aspects of PET imaging at both the animal and human level.« less

Temporal changes in lithology and radiochemistry from the back-barrier environments along the Chandeleur Islands, Louisiana: March 2012-July 2013

USGS Publications Warehouse

Marot, Marci E.; Adams, C. Scott; Richwine, Kathryn A.; Smith, Christopher G.; Osterman, Lisa E.; Bernier, Julie C.

2014-01-01

Scientists from the U.S. Geological Survey, St. Petersburg Coastal and Marine Science Center conducted a time-series collection of shallow sediment cores from the back-barrier environments along the Chandeleur Islands, Louisiana from March 2012 through July 2013. The sampling efforts were part of a larger USGS study to evaluate effects on the geomorphology of the Chandeleur Islands following the construction of an artificial sand berm to reduce oil transport onto federally managed lands. The objective of this study was to evaluate the response of the back-barrier tidal and wetland environments to the berm. This report serves as an archive for sedimentological, radiochemical, and microbiological data derived from the sediment cores. Data are available for a time-series of four sampling periods: March 2012; July 2012; September 2012; and July 2013. Downloadable data are available as Excel spreadsheets and as JPEG files. Additional files include: ArcGIS shapefiles of the sampling sites, detailed results of sediment grain size analyses, and formal Federal Geographic Data Committee metadata.

Future U.S. supply of Mo-99 production through fission based LEU/LEU technology.

PubMed

Welsh, James; Bigles, Carmen I; Valderrabano, Alejandro

Coquí RadioPharmaceuticals Corp. (Coquí) has the goal of establishing a medical isotope production facility for securing a continuous domestic supply of the radioisotope molybdenum-99 for U.S. citizens. Coquí will use an LEU/LEU proven and implemented open pool, light-water, 10 MW, reactor design. The facility is being designed with twin reactors for reliability an on-site hot lab chemical processing and a waste conditioning area and a possible generator producing radio-chemistry lab. Coquí identified a 25 acre site adjacent to an existing industrial park in northern central Florida. This land was gifted and transferred to Coquí by the University of Florida Foundation. We are in the process of developing licensing documents related to the facility. The construction permit application for submission to the U.S. Nuclear Regulatory Commission is currently being prepared. Submission is scheduled for mid to late 2015. Community reaction to the proposed development has been positive. We expect to create 220 permanent jobs and we have an anticipated to be operational by 2020.

Dendrimer Nanoscaffolds for Potential Theranostics of Prostate Cancer with a Focus on Radiochemistry

PubMed Central

Lo, Su-Tang; Kumar, Amit; Hsieh, Jer-Tsong; Sun, Xiankai

2013-01-01

Dendrimers are a class of structurally defined macromolecules featured with a central core, a low-density interior formed by repetitive branching units, and a high-density exterior terminated with surface functional groups. In contrast to their polymeric counterparts, dendrimers are nano-sized and symmetrically shaped, which can be reproducibly synthesized in a large scale with monodispersity. These unique features have made dendrimers of increasing interest for drug delivery and other biomedical applications as a nanoscaffold system. Intended to address the potential use of dendrimers for the development of theranostic agents, which combines therapeutics and diagnostics in a single entity for personalized medicine, this review focuses on the reported methodologies of using dendrimer nanoscaffolds for targeted imaging and therapy of prostate cancer. Of particular interest, relevant chemistry strategies are discussed due to their important roles in the design and synthesis of diagnostic and therapeutic dendrimer-based nanoconjugates and potential theranostic agents, targeted or non-targeted. Given the developing status of nanoscaffolded theranostics, major challenges and potential hurdles are discussed along with the examples representing current advances. PMID:23294202

Review of chemical and radiotoxicological properties of polonium for internal contamination purposes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ansoborlo, Eric; Berard, Philippe; Den Auwer, Christophe

2012-01-01

The discovery of polonium (Po) was first published in July 1898 by P. and M. Curie. It was the first element to be discovered by the radiochemical method. Polonium can be considered as a famous but neglected element: only a few studies of polonium chemistry have been published, mostly between 1950 and 1990. The recent (2006) event in which 2106 Po evidently was used as a poison to kill A. Litvinenko has raised new interest in polonium. 2011 being the 100th 8 anniversary of Marie Curie Nobel Prize in Chemistry, the aim of this paper is to review several aspectmore » of polonium linked to its chemical properties and its radiotoxicity, including : i) its radiochemistry and interaction with matter; ii) its main sources and uses; iii) its physico-chemical properties; iv) its main analytical methods; v) its background exposure risk in water, food, and other environmental media; vi) its biokinetics and distribution following inhalation, ingestion and wound contamination; vii) its dosimetry and viii) treatments available (decorporation) in case of internal contamination.« less

A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio.

PubMed

Grimes, David Robert; Partridge, Mike

2015-12-04

The presence of oxygen in tumours has substantial impact on treatment outcome; relative to anoxic regions, well-oxygenated cells respond better to radiotherapy by a factor 2.5-3. This increased radio-response is known as the oxygen enhancement ratio. The oxygen effect is most commonly explained by the oxygen fixation hypothesis, which postulates that radical-induced DNA damage can be permanently 'fixed' by molecular oxygen, rendering DNA damage irreparable. While this oxygen effect is important in both existing therapy and for future modalities such a radiation dose-painting, the majority of existing mathematical models for oxygen enhancement are empirical rather than based on the underlying physics and radiochemistry. Here we propose a model of oxygen-enhanced damage from physical first principles, investigating factors that might influence the cell kill. This is fitted to a range of experimental oxygen curves from literature and shown to describe them well, yielding a single robust term for oxygen interaction obtained. The model also reveals a small thermal dependency exists but that this is unlikely to be exploitable.

Review of chemical and radiotoxicological properties of polonium for internal contamination purposes.

PubMed

Ansoborlo, Eric; Berard, Philippe; Den Auwer, Christophe; Leggett, Rich; Menetrier, Florence; Younes, Ali; Montavon, Gilles; Moisy, Philippe

2012-08-20

The discovery of polonium (Po) was first published in July, 1898 by P. Curie and M. Curie. It was the first element to be discovered by the radiochemical method. Polonium can be considered as a famous but neglected element: only a few studies of polonium chemistry have been published, mostly between 1950 and 1990. The recent (2006) event in which (210)Po evidently was used as a poison to kill A. Litvinenko has raised new interest in polonium. 2011 being the 100th anniversary of the Marie Curie Nobel Prize in Chemistry, the aim of this review is to look at the several aspects of polonium linked to its chemical properties and its radiotoxicity, including (i) its radiochemistry and interaction with matter; (ii) its main sources and uses; (iii) its physicochemical properties; (iv) its main analytical methods; (v) its background exposure risk in water, food, and other environmental media; (vi) its biokinetics and distribution following inhalation, ingestion, and wound contamination; (vii) its dosimetry; and (viii) treatments available (decorporation) in case of internal contamination.

Evaluation of residual radioactivity in human tissues associated with weapons testing at the nevada test site. Technical report, 1 June 1981-31 March 1989

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wrenn, M.E.; Singh, N.P.; Paschoa, A.S.

1992-11-01

Residual radioactivity consisting of 239 Pu were measured by radiochemistry and alpha spectrometry in samples of bone and soft tissues from 100 autopsies or surgeries from northern and southwestern Utah and from control areas in Colorado and Pennsylvania. Based upon the isotopic ratio 240 Pu/239 Pu contamination was attributable to atmospheric weapons tests at the Nevada Test Site (NTS). In addition, 110 thyroid tissue samples obtained from tissue blocks made at autopsy of veterans dying at the VA hospital in Salt Lake City in the 1940's and 1950's were measured for 129 I (half life 16 million year) and 127more » I (stable) by neutron activation. The results were analyzed by year of death, by periods before and during atmospheric nuclear weapons testing at the NTS and by origin of usual residence. A model was developed to relate thyroid dose from 131 I to the measured 124/127 I ratios, and thyroid dose estimates were made based upon the measured ratios.« less

Electron beam irradiation of fluoropolymers containing polyethers

NASA Astrophysics Data System (ADS)

Bucio, E.; Burillo, G.; Tapia, F.; Adem, E.; Cedillo, G.; Cassidy, P. E.

2009-02-01

A highly fluorinated monomer, 1,3-bis(1,1,1,3,3,3-hexafluoro-2-pentafluorophenyl methoxy-2-propyl)benzene (12F-FBE) was polymerized with some diphenols by polycondensation and then was electron beam irradiated between 100 and 1000 kGy to determine degradation radiochemistry yield ( Gs) by gel permeation chromatography (GPC). The samples were characterized after irradiation by DSC, FTIR, and nuclear magnetic resonance (NMR). The fluoropolymers show apparent degradation in mechanical properties at 300 kGy, except 12F-FBE polymerized with biphenol and bisphenol A, when they did not show any apparent physical change up to 300 kGy; and continue to be flexible and transparent, with a radiochemical yield scission ( Gs) of 0.75, 0.53, 0.88, and 0.38 for 12F-FBE/SDL aliphatic, 12F-FBE/biphenol, 12F-FBE/bisphenol A, and 12F-FBE/bisphenol O, respectively. The number average molecular weights for three of the polymers decrease upon 1000 kGy irradiation to 10% of their original values; however, the polymer from bisphenol A is much more stable and its Mn decreases to only 24% of original.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wegemar, B.

Operating experiences from the Forsmark 3 and Oskarshamn 3 BWRs have been evaluated during the first two cycles of their operation. The objective of this work was to determine the influence on water chemistry quality and radiation field buildup from the special design characteristics of these plants. Important differences from older ASEA-ATOM BWRs include the concept of forward pumped high pressure heater drains, magnetic filtration of high pressure drains and use of more erosion-resistant materials in turbine components. Data obtained from water radiochemistry measurements, shutdown dose rates and gamma scanning surveys, fuel deposit analyses and occuptional exposure statistics have beenmore » used in order to enable a comparsion to older ASEA-ATOM BWRs. At the end of the second cycles, satisfactory feedwater quality was reported in both plants. Radiation levels around components in the primary systems are higher in Forsmark 3 and Oskarshamn 3 as compared to other plants. This is in agreement with reactor water activities, fuel deposits and gamma scanning surveys, indicating somewhat higher amounts of cobalt-60 and cobalt-58. However, in both plants occupational exposures were low during the first two years of operation.« less

Novel Approach to Prepare {sup 99m}Tc-Based Multivalent RGD Peptides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shuang Liu

2012-10-24

This project presents a novel approach to prepare the {sup 99m}Tc-bridged multivalent RGD (arginine-glycine-aspartate) peptides. This project will focus on fundamentals of {sup 99m}Tc radiochemistry. The main objective of this project is to demonstrate the proof-of-principle for the proposed radiotracers. Once a kit formulation is developed for preparation of the {sup 99m}Tc-bridged multivalent RGD peptides, various tumor-bearing animal models will be used to evaluate their potential for SPECT (single photon-emission computed tomography) imaging of cancer. We have demonstrated that (1) multimerization of cyclic RGD peptides enhances the integrin {alpha}{sub v}{beta}{sub 3} bonding affinity and radiotracer tumor uptake; (2) addition ofmore » G{sub 3} or PEG{sub 4} linkers makes it possible for two RGD motifs in 3P-RGD{sub 2} and 3G-RGD{sub 2} to achieve simultaneous integrin {alpha}{sub v}{beta}{sub 3} binding; and (3) multimers are actually bivalent (not multivalent), the presence of extra RGD motifs can enhance the tumor retention time of the radiotracer.« less

USAF Summer Research Program - 1993 Graduate Student Research Program Final Reports, Volume 8, Phillips Laboratory

DTIC Science & Technology

1994-12-01

Research Program Phillips Laboratory Kirtland Air Force Base Albuquerque, New Mexico Sponsored by: Air ...Summer Research Program Phillips Laboratory Sponsored by. Air Force Office of Scientific Research Kirtland Air Force Base, Albuquerque, New Mexico...UNITED STATES AIR FORCE SUMMER RESEARCH PROGRAM -- 1993 SUMMER RESEARCH PROGRAM FINAL REPORTS VOLUME 8

5 CFR 470.205 - Initiation of research programs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Initiation of research programs. 470.205... PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.205 Initiation of research programs. OPM will announce opportunities for research...

5 CFR 470.205 - Initiation of research programs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Initiation of research programs. 470.205... PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.205 Initiation of research programs. OPM will announce opportunities for research...

NASA Lewis Research Center/university graduate research program on engine structures

NASA Technical Reports Server (NTRS)

Chamis, C. C.

1985-01-01

NASA Lewis Research Center established a graduate research program in support of the Engine Structures Research activities. This graduate research program focuses mainly on structural and dynamics analyses, computational mechanics, mechanics of composites and structural optimization. The broad objectives of the program, the specific program, the participating universities and the program status are briefly described.

NASA Lewis Research Center/University Graduate Research Program on Engine Structures

NASA Technical Reports Server (NTRS)

Chamis, C. C.

1985-01-01

NASA Lewis Research Center established a graduate research program in support of the Engine Structures Research activities. This graduate research program focuses mainly on structural and dynamics analyses, computational mechanics, mechanics of composites and structural optimization. The broad objectives of the program, the specific program, the participating universities and the program status are briefly described.

LTRC Annual Research Program : Fiscal Year July 1, 2017 - June 30, 2018.

DOT National Transportation Integrated Search

2017-06-01

FHWA Part II SPR Research Program FAP Number SPR-0010(34) & FHWA Funded Research Program & FHWA LTAP Funded Program & FHWA STP Funded Program & Federal & Self-Generated Funded Research Program & Other DOTD Funded Projects

LTRC Annual Research Program : Fiscal Year July 1, 2012-June 30, 2013

DOT National Transportation Integrated Search

2012-06-01

Contents: Budget Recap Sheets; Project Summary Sheets; FHWA Part II SPR Funded Research Program; FHWA IBRD Funded Research Program; FHWA LTAP Funded Program; FHWA STP Funded Technology Transfer & Education Program; State Funded Research Program; Fede...

LTRC annual research program : fiscal year July 1, 2011-June 30, 2012.

DOT National Transportation Integrated Search

2011-06-01

Contents: Budget Recaps Sheets; Project Summary Sheets; FHWA Part II SPR Funded Research Program; FHWA IBRD Funded Research Program; FHWA LTAP Funded Program; FHWA STP Funded Technology Transfer & Education Program; State Funded Research Program; Sel...

Resident research in internal medicine training programs.

PubMed

Alguire, P C; Anderson, W A; Albrecht, R R; Poland, G A

1996-02-01

To determine how well medical residency programs are prepared to meet the new Accreditation Council of Graduate Medical Education (ACGME) accreditation guidelines for resident scholarly activity. Cross-sectional study using a mailed survey. Program directors of all ACGME-accredited internal medicine residency programs. Program directors were asked to list the scholarly activities and products of their residents and their programs' minimal expectations for resident research; available academic, faculty, technical, and personnel support for resident research; perceived barriers to resident research; and the desired educational and skill outcomes of resident research. The responses of university-based training programs were compared with those of non-university-based programs. 271 program directors returned the survey, yielding a response rate of 65%. Ninety-seven percent of all programs have established scholarly guidelines consistent with accreditation requirements. Although only 37% of programs reported having an organized, comprehensive research curriculum, 70% taught skills important to research. Technical support and resources were generally available for resident research; the most frequently cited barrier to resident research was lack of resident time. University-based and non-university-based training programs differed in important ways. Generally, non-university-based programs had more research activity and structure, and they exceeded university-based programs in the number of oral and poster presentations given at local, state, and national professional meetings. Most programs have in place the basic elements conducive to resident research. Program directors have identified and teach educational outcomes and skills that are likely to have lifelong benefits for most of their graduates.

USAF Summer Research Program - 1993 Summer Research Extension Program Final Reports, Volume 2, Phillips Laboratory

DTIC Science & Technology

1994-11-01

Research Extension Program Phillips Laboratory Kirtland Air Force Base Sponsored by: Air Force Office of Scientific Research Boiling Air Force Base...Program Phillips Laboratory Sponsored by: Air Force Office of Scientific Research Bolling Air Force Base, Washington, D.C. and Arkansas Tech University...Summer Research Extension Program (SREP) Phillips

The development of a TED-Ed online resident research training program.

PubMed

Moreau, Katherine A; Pound, Catherine M; Peddle, Beth; Tokarewicz, Jaclyn; Eady, Kaylee

2014-01-01

Pediatric health research is important for improving the health and well-being of children and their families. To foster the development of physicians' research competencies, it is vital to integrate practical and context-specific research training into residency programs. To describe the development of a resident research training program at one tertiary care pediatric academic health sciences center in Ontario, Canada. We surveyed residents and pediatricians/research staff to establish the need and content for a resident research training program. Residents and resident research supervisors agreed or strongly agreed that research training is important for residents. However, few residents and supervisors believed that their academic health sciences center provided adequate training and resources to support resident research. As such, an online resident research training program was established. Residents and supervisors agreed that the program should focus on the following topics: 1) critically evaluating research literature, 2) writing a research proposal, 3) submitting an application for research funding, and 4) writing a manuscript. This highly accessible, context-specific, and inexpensive online program model may be of interest and benefit to other residency programs as a means to enhance residents' scholarly roles. A formal evaluation of the research training program is now underway.

Status of anesthesiology resident research education in the United States: structured education programs increase resident research productivity.

PubMed

Ahmad, Shireen; De Oliveira, Gildasio S; McCarthy, Robert J

2013-01-01

The enhancement of resident research education has been proposed to increase the number of academic anesthesiologists with the skills and knowledge to conduct meaningful research. Program directors (PDs) of the U.S. anesthesiology residency programs were surveyed to evaluate the status of research education during residency training and to test the hypothesis that structured programs result in greater resident research productivity based on resident publications. Survey responses were solicited from 131 anesthesiology residency PDs. Seventy-four percent of PDs responded to the survey. Questions evaluated department demographic information, the extent of faculty research activity, research resources and research funding in the department, the characteristics of resident research education and resident research productivity, departmental support for resident research, and perceived barriers to resident research education. Thirty-two percent of programs had a structured resident research education program. Structured programs were more likely to be curriculum based, require resident participation in a research project, and provide specific training in presentation and writing skills. Productivity expectations were similar between structured and nonstructured programs. Forty percent of structured programs had > 20% of trainees with a publication in the last 2 years compared with 14% of departments with unstructured programs (difference, 26%; 99% confidence interval [CI], 8%-51%; P = 0.01). The percentage of programs that had research rotations for ≥2 months was not different between the structured and the nonstructured programs. A research rotation of >2 months did not increase the percentage of residents who had published an article within the last 2 months compared with a research rotation of <2 months (difference, 13%; 99% CI, 10%-37%; P = 0.14). There was no difference in the percentage of faculty involved in research in structured compared with unstructured research education. In programs with <20% of faculty involved in research, 15% reported >20% of residents with a publication in the last 2 years compared with 36% in programs with >20% of faculty involvement (difference, 21%; 99% CI, -4% to 46%; P = 0.03). Our findings suggest that structured residency research programs are associated with higher resident research productivity. The program duration and the fraction of faculty in resident research education did not significantly increase research productivity. Research training is an integral component of resident education, but the mandatory enhancement of resident research education will require a significant change in the culture of academic anesthesiology leadership and faculty.

LTRC annual research program : fiscal year July 1, 2015 - June 30, 2016.

DOT National Transportation Integrated Search

2015-06-01

Contents: Budget Recap Sheets; Project Summary Sheets; FHWA Part II SPR Funded Research Program; FHWA LTAP Funded Program; FHWA STP Funded Technology Transfer & Education Program; State Funded Research Program; Self-Generated Funded Research; Other D...

History of the State Water Resources Research Institute Program

USGS Publications Warehouse

Burton, J.S.

1984-01-01

The State Water Resources Research Institute Program, established in 1964, consists of 54 Water Resources Research Institutes located at land-grant universities in each of the 50 states and Puerto Rico, the District of Columbia, Guam, and the Virgin Islands. The program evolved from the Water Resources Research Act of 1964, as amended, the Water Research and Development Act of 1978, Public Law 94-457, and the Water Research and Development Act of 1984. These laws authorize the following components of the Institute Program: (1) the annual allotment and matching grants program for the institutes and (2) the additional and saline water research programs for organizations in addition to the State Water Resources Research Institutes. This report summarizes the legislative history, budget history, research program development, and program accomplishments. The State Water Resources Research Program has been administered to by the Office of Water Resources Research (OWRR) (1964-1974), the Office of Water Research and Technology (OWRT) (1974-1982), the Office of Water Policy (OWP) (1982-1983) , and the U.S. Geological Survey (USGS) (1983-present). (USGS)

77 FR 10455 - National Institutes of Health Loan Repayment Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-22

... Repayment Program for Research with Respect to Acquired Immune Deficiency Syndrome (or AIDS Research LRP); Loan Repayment Program for General Research (or General Research LRP), which includes a program for the... Researchers from Disadvantaged Backgrounds (or Clinical Research LRP for Individuals from Disadvantaged...

Role of EPA in Asset Management Research – The Aging Water Infrastructure Research Program

EPA Science Inventory

This slide presentation provides an overview of the EPA Office of Research and Development’s Aging Water infrastructure Research Program (AWIRP). The research program origins, goals, products, and plans are described. The research program focuses on four areas: condition asses...

United States Air Force Summer Research Program -- 1992 High School Apprenticeship Program (HSAP) Reports. Volume 13. Phillips Laboratory

DTIC Science & Technology

1992-01-01

Research Program Phillips Laboratory I4oJ A*6Iv4 Sponsored by: Air Force Office of Scientific Research Kirtland Air ...UNITED STATES AIR FORCE SUMMER RESEARCH PROGki"A -- 1992 HIGH SCHOOL APPRENTICESHIP PROGRAM (HSAP) REPORTS VOLUME 13 (t PHILLIPS LABORATORY . RESEARCH ...Arlington High School Final Report for: Summer Research Program Geophysics Directorate Phillips Laboratory

7 CFR 3406.17 - Program application materials-research.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Program application materials-research. 3406.17... FOOD AND AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Preparation of a Research Proposal § 3406.17 Program application materials—research. Program application materials in an application...

7 CFR 3406.17 - Program application materials-research.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Program application materials-research. 3406.17... FOOD AND AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Preparation of a Research Proposal § 3406.17 Program application materials—research. Program application materials in an application...

7 CFR 3406.17 - Program application materials-research.

Code of Federal Regulations, 2011 CFR

2011-01-01

... FOOD AND AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Preparation of a Research Proposal § 3406.17 Program application materials—research. Program application materials in an application... 7 Agriculture 15 2011-01-01 2011-01-01 false Program application materials-research. 3406.17...

77 FR 46805 - Small Business Innovation Research Program Policy Directive

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

... Small Business Innovation Research Program Policy Directive; Small Business Technology Transfer Program Policy Directive; Small Business Innovation Research (SBIR) Program and Small Business Technology... ADMINISTRATION 13 CFR Chapter I RIN 3245-AF84 Small Business Innovation Research Program Policy Directive AGENCY...

The development of a TED-Ed online resident research training program

PubMed Central

Moreau, Katherine A.; Pound, Catherine M.; Peddle, Beth; Tokarewicz, Jaclyn; Eady, Kaylee

2014-01-01

Background Pediatric health research is important for improving the health and well-being of children and their families. To foster the development of physicians’ research competencies, it is vital to integrate practical and context-specific research training into residency programs. Purpose To describe the development of a resident research training program at one tertiary care pediatric academic health sciences center in Ontario, Canada. Methods We surveyed residents and pediatricians/research staff to establish the need and content for a resident research training program. Results Residents and resident research supervisors agreed or strongly agreed that research training is important for residents. However, few residents and supervisors believed that their academic health sciences center provided adequate training and resources to support resident research. As such, an online resident research training program was established. Residents and supervisors agreed that the program should focus on the following topics: 1) critically evaluating research literature, 2) writing a research proposal, 3) submitting an application for research funding, and 4) writing a manuscript. Discussion This highly accessible, context-specific, and inexpensive online program model may be of interest and benefit to other residency programs as a means to enhance residents’ scholarly roles. A formal evaluation of the research training program is now underway. PMID:25526717

The development of a TED-Ed online resident research training program.

PubMed

Moreau, Katherine A; Pound, Catherine M; Peddle, Beth; Tokarewicz, Jaclyn; Eady, Kaylee

2014-01-01

Background Pediatric health research is important for improving the health and well-being of children and their families. To foster the development of physicians' research competencies, it is vital to integrate practical and context-specific research training into residency programs. Purpose To describe the development of a resident research training program at one tertiary care pediatric academic health sciences center in Ontario, Canada. Methods We surveyed residents and pediatricians/research staff to establish the need and content for a resident research training program. Results Residents and resident research supervisors agreed or strongly agreed that research training is important for residents. However, few residents and supervisors believed that their academic health sciences center provided adequate training and resources to support resident research. As such, an online resident research training program was established. Residents and supervisors agreed that the program should focus on the following topics: 1) critically evaluating research literature, 2) writing a research proposal, 3) submitting an application for research funding, and 4) writing a manuscript. Discussion This highly accessible, context-specific, and inexpensive online program model may be of interest and benefit to other residency programs as a means to enhance residents' scholarly roles. A formal evaluation of the research training program is now underway.

United States Air Force Summer Research Program -- 1993. Volume 8. Phillips Laboratory

DTIC Science & Technology

1993-12-01

Research Program Phillips Laboratory Kirtland Air Force Base Albuquerque. New Mexico Sponsored by...Best Available Copy UNITED STATES AIR FORCE SUMMER RESEARCH PROGRAM -- 1993 SUMMER RESEARCH PROGRAM FINAL REPORTS VOLUME 8 PHILLIPS LABORATORY ...Alabama Box 870344 Tuscaloosa, AL 35487-0344 Final Report for: Graduate Student Research Program Phillips Laboratory , Hanscom AFB Sponsored by: Air

10 CFR Appendix A to Part 605 - The Energy Research Program Office Descriptions

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false The Energy Research Program Office Descriptions A Appendix... RESEARCH FINANCIAL ASSISTANCE PROGRAM Pt. 605, App. A Appendix A to Part 605—The Energy Research Program Office Descriptions 1. Basic Energy Sciences This program supports basic science research efforts in a...

10 CFR Appendix A to Part 605 - The Energy Research Program Office Descriptions

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false The Energy Research Program Office Descriptions A Appendix... RESEARCH FINANCIAL ASSISTANCE PROGRAM Pt. 605, App. A Appendix A to Part 605—The Energy Research Program Office Descriptions 1. Basic Energy Sciences This program supports basic science research efforts in a...

10 CFR Appendix A to Part 605 - The Energy Research Program Office Descriptions

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false The Energy Research Program Office Descriptions A Appendix... RESEARCH FINANCIAL ASSISTANCE PROGRAM Pt. 605, App. A Appendix A to Part 605—The Energy Research Program Office Descriptions 1. Basic Energy Sciences This program supports basic science research efforts in a...

10 CFR Appendix A to Part 605 - The Energy Research Program Office Descriptions

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false The Energy Research Program Office Descriptions A Appendix... RESEARCH FINANCIAL ASSISTANCE PROGRAM Pt. 605, App. A Appendix A to Part 605—The Energy Research Program Office Descriptions 1. Basic Energy Sciences This program supports basic science research efforts in a...

Reforming the community research program: from Community Clinical Oncology Program to the National Cancer Institute Community Oncology Research Program.

PubMed

Zon, Robin T

2014-01-01

Community research has been an integral and influential component of the National Research Program since the late 1970s. Institutionalization of community research in the Community Clinical Oncology Program (CCOP) has resulted in successful collaborations, meaningful accrual, achievement of quality standards, and translation of research into clinical practice. Although the national clinical trial system is undergoing modernization and improvement, the success of the CCOP and minority-based CCOP in cancer treatment, prevention, and control research is being extended to include cancer care delivery research in the newly created National Cancer Institute (NCI) Community Oncology Research Program. This article briefly presents a historic perspective of community involvement in federally sponsored clinical trials and introduces the continued involvement in the newly created NCI program.

The Social Welfare Practice and Research Center at the Chinese University of Hong Kong

ERIC Educational Resources Information Center

Shek, Daniel T. L.

2009-01-01

The organization and research programs of the Social Welfare Practice and Research Centre (SWPRC) at the Chinese University of Hong Kong are outlined. There are five regular research programs (Family and Group Practice Research Centre, Human Behavior and the Social Environment Research Program, Mutual Aid and Social Capital Research Program,…

7 CFR 3406.17 - Program application materials-research.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Program application materials-research. 3406.17... RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Preparation of a Research Proposal § 3406.17 Program application materials—research...

Otolaryngology Residency Program Research Resources and Scholarly Productivity.

PubMed

Villwock, Jennifer A; Hamill, Chelsea S; Nicholas, Brian D; Ryan, Jesse T

2017-06-01

Objective To delineate research resources available to otolaryngology residents and their impact on scholarly productivity. Study Design Survey of current otolaryngology program directors. Setting Otolaryngology residency programs. Subjects and Methods An anonymous web-based survey was sent to 98 allopathic otolaryngology training program directors. Fisher exact tests and nonparametric correlations were used to determine statistically significant differences among various strata of programs. Results Thirty-nine percent (n = 38) of queried programs responded. Fourteen (37%) programs had 11 to 15 full-time, academic faculty associated with the residency program. Twenty (53%) programs have a dedicated research coordinator. Basic science lab space and financial resources for statistical work were present at 22 programs (58%). Funding is uniformly provided for presentation of research at conferences; a minority of programs (13%) only funded podium presentations. Twenty-four (63%) have resident research requirements beyond the Accreditation Council for Graduate Medical Education (ACGME) mandate of preparing a "manuscript suitable for publication" prior to graduation. Twenty-five (67%) programs have residents with 2 to 3 active research projects at any given time. None of the investigated resources were significantly associated with increased scholarly output. There was no uniformity to research curricula. Conclusions Otolaryngology residency programs value research, evidenced by financial support provided and requirements beyond the ACGME minimum. Additional resources were not statistically related to an increase in resident research productivity, although they may contribute positively to the overall research experience during training. Potential future areas to examine include research curricula best practices, how to develop meaningful mentorship and resource allocation that inspires continued research interest, and intellectual stimulation.

A dedicated research program increases the quantity and quality of orthopaedic resident publications.

PubMed

Torres, Daniel; Gugala, Zbigniew; Lindsey, Ronald W

2015-04-01

Programs seek to expose trainees to research during residency. However, little is known in any formal sense regarding how to do this effectively, or whether these efforts result in more or better-quality research output. The objective of our study was to evaluate a dedicated resident research program in terms of the quantity and quality of resident research peer-reviewed publications. Specifically we asked: (1) Did residents mentored through a dedicated resident research program have more peer-reviewed publications in higher-impact journals with higher citation rates compared with residents who pursued research projects under a less structured approach? (2) Did this effect continue after graduation? In 2006, our department of orthopaedic surgery established a dedicated resident research program, which consisted of a new research policy and a research committee to monitor quality and compliance with this policy. Peer-reviewed publications (determined from PubMed) of residents who graduated 6 years before establishing the dedicated resident research program were compared with publications from an equal period of the research-program-directed residents. The data were assessed using descriptive statistics and regression analysis. Twenty-four residents graduated from 2001 to 2006 (before implementation of the dedicated resident research program); 27 graduated from 2007 to 2012 (after implementation of the dedicated resident research program). There were 74 eligible publications as defined by the study inclusion and exclusion criteria. Residents who trained after implementation of the dedicated resident research program published more papers during residency than did residents who trained before the program was implemented (1.15 versus 0.79 publications per resident; 95% CI [0.05,0.93]; p = 0.047) and the journal impact factor was greater in the group that had the research program (1.25 versus 0.55 per resident; 95% CI [0.2,1.18]; p = 0.005). There were no differences between postresidency publications by trainees who graduated with versus without the research program in the number of publications, citations, and average journal impact factor per resident. A regression analysis showed no difference in citation rates of the residents' published papers before and since implementation of the research program. Currently in the United States, there are no standard policies or requirements that dictate how research should be incorporated in orthopaedic surgery residency training programs. The results of our study suggest that implementation of a dedicated resident research program improves the quantity and to some extent quality of orthopaedic resident research publications, but this effect did not persist after graduation.

American Society for Engineering Education/NASA Summer Faculty Fellowship Program 1982

NASA Technical Reports Server (NTRS)

Spencer, J. H. (Compiler)

1983-01-01

A program of summer faculty fellowships for engineering and science educators is described. The program involves participation in cooperative research and study. Results of the program evaluation are summarized. The research fellows indicated satisfaction with the program. Benefits of the program cited include: (1) enhancement of professional abilities; (2) contact with professionals in a chosen area of research; (3) familiarity with research facilities; and (4) development of new research techniques and their adaptation to an academic setting. Abstracts of each of the research projects undertaken are presented.

15 CFR 256.2 - The Research Associate Program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false The Research Associate Program. 256.2... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES RESEARCH ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific...

15 CFR 256.2 - The Research Associate Program.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false The Research Associate Program. 256.2... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES RESEARCH ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific...

15 CFR 256.2 - The Research Associate Program.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false The Research Associate Program. 256.2... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES RESEARCH ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific...

Challenges in Measuring Benefit of Clinical Research Training Programs--the ASH Clinical Research Training Institute Example.

PubMed

Sung, Lillian; Crowther, Mark; Byrd, John; Gitlin, Scott D; Basso, Joe; Burns, Linda

2015-12-01

The American Society of Hematology developed the Clinical Research Training Institute (CRTI) to address the lack of training in patient-oriented research among hematologists. As the program continues, we need to consider metrics for measuring the benefits of such a training program. This article addresses the benefits of clinical research training programs. The fundamental and key components are education and mentorship. However, there are several other benefits including promotion of collaboration, job and advancement opportunities, and promotion of work-life balance. The benefits of clinical research training programs need to be measured so that funders and society can judge if they are worth the investment in time and resources. Identification of elements that are important to program benefit is essential to measuring the benefit of the program as well as program planning. Future work should focus on the constructs which contribute to benefits of clinical research training programs such as CRTI.

Processes and Procedures of the Higher Education Programs at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Heard, Pamala D.

2002-01-01

The purpose of my research was to investigate the policies, processes, procedures and timelines for the higher education programs at Marshall Space Flight Center. The three higher education programs that comprised this research included: the Graduate Student Researchers Program (GSRP), the National Research Council/Resident Research Associateships Program (NRC/RRA) and the Summer Faculty Fellowship Program (SFFP). The GSRP award fellowships each year to promising U.S. graduate students whose research interest coincides with NASA's mission. Fellowships are awarded for one year and are renewable for up to three years to competitively selected students. Each year, the award provides students the opportunity to spend a period in residence at a NASA center using that installation's unique facilities. This program is renewable for three years, students must reapply. The National Research Council conducts the Resident Research Associateships Program (NRC/RRA), a national competition to identify outstanding recent postdoctoral scientists and engineers and experience senior scientists and engineers, for tenure as guest researchers at NASA centers. The Resident Research Associateship Program provides an opportunity for recipients of doctoral degrees to concentrate their research in association with NASA personnel, often as a culmination to formal career preparation. The program also affords established scientists and engineers an opportunity for research without any interruptions and distracting assignments generated from permanent career positions. All opportunities for research at NASA Centers are open to citizens of the U.S. and to legal permanent residents. The Summer Faculty Fellowship Program (SFFP) is conducted each summer. NASA awards research fellowships to university faculty through the NASA/American Society for Engineering Education. The program is designed to promote an exchange of ideas between university faculties, NASA scientists and engineers. Selected participants in fields of science, engineering, math, and other disciplines spend approximately 10 weeks working with their professional peers on research projects at NASA facilities. Workshops and seminars further enrich the experience. This program is only for U.S. citizens.

Production and separation of (186g)Re from proton bombardment of (186)WC.

PubMed

Richards, Vernal N; Rath, Nigam; Lapi, Suzanne E

2015-06-01

A proof of concept study was undertaken where non-carrier added (186 g)Re was produced from the cyclotron bombardment of (186)WC. (186)WC was carbo-thermally generated from a novel precursor synthesized from (186)WO3, aqueous ammonia and hexamethyltetramine. The inherent high electrical and thermal conductivity of this material, coupled with its high melting point, made it an ideal candidate for proton bombardment for production of (186)Re. An18 μA irradiation for 3h and processing via thermo-chromatography, (186)WC yielded 0.93 mCi of (186 g)Re which corresponds to 89% of the calculated theoretical yields. The radiochemical purity of the desired (186 g)Re species was found to be between 95 and 97% with small contaminants of (186)ReO2. The radiochemistry utility of the product was investigated using S-benzoyl-MAG3, and 100% complexation was achieved with stability being maintained for 96 h. The re-oxidation of (186)WC back to(186)WO3 by oxygen in the thermo-chromatography method of processing ensured that the starting material was regenerated and recovered from the process in 94-98% yield. Copyright © 2015 Elsevier Inc. All rights reserved.

Automated solid-phase radiofluorination using polymer-supported phosphazenes.

PubMed

Mathiessen, Bente; Zhuravlev, Fedor

2013-08-30

The polymer supported phosphazene bases PS-P₂(tBu) and the novel PS-P₂(PEG) allowed for efficient extraction of [¹⁸F]F⁻ from proton irradiated [¹⁸O]H₂O and subsequent radiofluorination of a broad range of substrates directly on the resin. The highest radiochemical yields were obtained with aliphatic sulfonates (69%) and bromides (42%); the total radiosynthesis time was 35-45 min. The multivariate analysis showed that the radiochemical yields and purities were controlled by the resin load, reaction temperature, and column packing effects. The resins could be reused several times with the same or different substrates. The fully automated on-column radiofluorination methodology was applied to the radiosynthesis of the important PET radiotracers [¹⁸F]FLT and [¹⁸F]FDG. The latter was produced with 40% yield on a 120 GBq scale and passed GMP-regulated quality control required for commercial production of [1¹⁸F]FDG. The combination of compact form factor, simplicity of [¹⁸F]F⁻ recovery and processing, and column reusability can make solid phase radiofluorination an attractive radiochemistry platform for the emerging dose-on-demand instruments for bedside production of PET radiotracers.

Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip

PubMed Central

Kimura, Hiroyuki; Tomatsu, Kenji; Saiki, Hidekazu; Arimitsu, Kenji; Ono, Masahiro; Kawashima, Hidekazu; Iwata, Ren; Nakanishi, Hiroaki; Ozeki, Eiichi; Kuge, Yuji; Saji, Hideo

2016-01-01

In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a hot cell. To develop more compact microreactors for radiosynthesis of 18F-labeled compounds required for the multistep procedure, we attempted radiosynthesis of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) via a three-step procedure using a microreactor. We examined individual steps for [18F]SFB using a batch reactor and microreactor and developed a new continuous-flow synthetic method with a single microfluidic chip to achieve rapid and efficient radiosynthesis of [18F]SFB. In the synthesis of [18F]SFB using this continuous-flow method, the three-step reaction was successfully completed within 6.5 min and the radiochemical yield was 64 ± 2% (n = 5). In addition, it was shown that the quality of [18F]SFB synthesized on this method was equal to that synthesized by conventional methods using a batch reactor in the radiolabeling of bovine serum albumin with [18F]SFB. PMID:27410684

Evaluation of 99mTc labeled diadenosine tetraphosphate as an atherosclerotic plaque imaging agent in experimental models.

PubMed

Cao, Wei; Zhang, Yongxue; An, Rui

2006-01-01

The potential of 99mTc labeled P1, P4-di (adenosine-5')-tetraphosphate (Ap4A) for imaging experimental atherosclerotic plaques was evaluated in New Zealand white (NZW) rabbits. To label the 99mTc to Ap4A, stannous tartrate solution was used. 99mTc-Ap4A was purified on a Sephadex G-25 column. The radiochemistry purities of 99mTc-Ap4A were 85% to 91%. Biodistribution study revealed 99mTc-Ap4A cleared from blood rapidly. Thirty min after 99mTc-Ap4A administrated on NZW atherosclerotic rabbits, lesion to blood (target/blood, T/B) ratio was 3.17 +/- 1.27, and lesions to normal (target/non-target, T/NT) ratio was 5.23 +/- 1.87. Shadows of atherosclerotic plaques were clearly visible on radioautographic film. Aortas with atherosclerotic plaques also could be seen on ex vivo gamma camera images. Atherosclerotic abdominal aortas were clearly visible on in vivo images 15 min to 3 h after 99mTc-Ap4A administration. 99mTc-labeled Ap4A can be used for rapid noninvasive detection of experimental atherosclerotic plaque.

Intrinsic radiolabeling of Titanium-45 using mesoporous silica nanoparticles.

PubMed

Chen, Feng; Valdovinos, Hector F; Hernandez, Reinier; Goel, Shreya; Barnhart, Todd E; Cai, Weibo

2017-06-01

Titanium-45 ( 45 Ti) with a three-hour half-life (t 1/2 =3.08 h), low maximum positron energy and high positron emission branching ratio, is a suitable positron emission tomography (PET) isotope whose potential has not yet been fully explored. Complicated radiochemistry and rapid hydrolysis continue to be major challenges to the development of 45 Ti compounds based on a traditional chelator-based radiolabeling strategy. In this study we introduced an intrinsic (or chelator-free) radiolabeling technique for the successful labeling of 45 Ti using mesoporous silica nanoparticle (MSN). We synthesized uniform MSN with an average particle size of ∼150 nm in diameter. The intrinsic 45 Ti-labeling was accomplished through strong interactions between 45 Ti (hard Lewis acid) and hard oxygen donors (hard Lewis bases), the deprotonated silanol groups (-Si-O-) from the outer surface and inner meso-channels of MSN. In vivo tumor-targeted PET imaging of as-developed PEGylated [ 45 Ti]MSN was further demonstrated in the 4T1 murine breast tumor-bearing mice. This MSN-based intrinsic radiolabeling strategy could open up new possibilities and speed up the biomedical applications of 45 Ti in the future.

48 CFR 227.7204 - Contracts under the Small Business Innovative Research Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Business Innovative Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovative Research Program. When contracting under the Small Business Innovative Research Program, follow the procedures at 227-7104. ...

Research studies with the International Ultraviolet Explorer

NASA Technical Reports Server (NTRS)

1991-01-01

The IUE research studies comprises 118 separate research programs involving observations, data analysis, and research conducted of the IUE satellite and the NASA Astrophysics Data Program. Herein are presented 92 programs. For each program there is a title, program ID, name of the investigator, statement of work, summary of results, and list of publications.

Human Research Program Exploration Medical Capability

NASA Technical Reports Server (NTRS)

Barsten, Kristina

2010-01-01

NASA s Human Research Program (HRP) conducts and coordinates research projects that provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. The Program is divided into 6 major elements, which a) Provide the Program s knowledge and capabilities to conduct research, addressing the human health and performance risks. b) Advance the readiness levels of technology and countermeasures to the point of transfer to the customer programs and organizations. The National Space Biomedical Research Institute (NSBRI) is a partner with the HRP in developing a successful research program. 3

USAF Summer Research Program - 1994 Graduate Student Research Program Final Reports, Volume 8, Phillips Laboratory

DTIC Science & Technology

1994-12-01

Research Group at the Phillips Laboratory at Kirtland Air Force Base...for Summer Graduate Student Research Program Phillips Laboratory Sponsored by: Air Force Office of Scientific Research Boiling Air Force Base, DC...2390 S. York Street Denver, CO 80208-0177 Final Report for: Summer Faculty Research Program Phillips Laboratory Sponsored by: Air Force

Effect of two Howard Hughes Medical Institute research training programs for medical students on the likelihood of pursuing research careers.

PubMed

Fang, Di; Meyer, Roger E

2003-12-01

To assess the effect of Howard Hughes Medical Institute's (HHMI) two one-year research training programs for medical students on the awardees' research careers. Awardees of the HHMI Cloister Program who graduated between 1987 and 1995 and awardees of the HHMI Medical Fellows Program who graduated between 1991 and 1995 were compared with unsuccessful applicants to the programs and MD-PhD students who graduated during the same periods. Logistic regression analyses were conducted to assess research career outcomes while controlling for academic and demographic variables that could affect selection to the programs. Participation in both HHMI programs increased the likelihood of receiving National Institutes of Health postdoctoral support. Participation in the Cloister Program also increased the likelihood of receiving a faculty appointment with research responsibility at a medical school. In addition, awardees of the Medical Fellows Program were not significantly less likely than Medical Scientist Training Program (MSTP) and non-MSTP MD-PhD program participants to receive a National Institutes of Health postdoctoral award, and awardees of the Cloister Program were not significantly less likely than non-MSTP MD-PhD students to receive a faculty appointment with research responsibility. Women and underrepresented minority students were proportionally represented among awardees of the two HHMI programs whereas they were relatively underrepresented in MD-PhD programs. The one-year intensive research training supported by the HHMI training programs appears to provide an effective imprinting experience on medical students' research careers and to be an attractive strategy for training physician-scientists.

NASA-OAI Collaborative Aerospace Research and Fellowship Program at NASA Glenn Research Center at Lewis Field

NASA Technical Reports Server (NTRS)

Heyward, Ann O.; Montegani, Francis J.

2003-01-01

During the summer of 2002, a IO-week activity for university faculty entitled the NASA-OAI Collaborative Aerospace Research and Fellowship Program (CFP) was conducted at the NASA Glenn Research Center in collaboration with the Ohio Aerospace Institute (OAI). This is a companion program to the highly successful NASA Faculty Fellowship Program and its predecessor, the NASA- ASEE Summer Faculty Fellowship Program, that operated for 38 years at Glenn. This year s program began officially on June 3, 2002 and continued through August 9, 2002. This report is intended primarily to summarize the research activities comprising the 2002 CFP Program at Glenn. Fifteen research summaries are included.

An Assessment of Research-Doctorate Programs in the United States: Humanities.

ERIC Educational Resources Information Center

Jones, Lyle V., Ed.; And Others

U.S. research-doctorate programs in the humanities were assessed by a committee of the Conference Board of Associated Research Councils. Attention was focused on 522 programs in nine disciplines in the humanities that award research doctorates. The effectiveness of these programs in preparing students for research careers was assessed. Indices…

Creation of an American Holistic Nurses Association research consultation program.

PubMed

Robertson, Sue; Clingerman, Evelyn; Zahourek, Rothlyn P; Mariano, Carla; Lange, Bernadette

2012-12-01

A goal of the American Holistic Nurses Association (AHNA) Research Committee is to prepare holistic nurses to conduct holistic nursing research. This article describes the creation of a Research Consultation Program and how the knowledge gained from the program will contribute to the development of a formal research mentor program.

The NASA Space Radiation Research Program

NASA Technical Reports Server (NTRS)

Cucinotta, Francis A.

2006-01-01

We present a comprehensive overview of the NASA Space Radiation Research Program. This program combines basic research on the mechanisms of radiobiological action relevant for improving knowledge of the risks of cancer, central nervous system and other possible degenerative tissue effects, and acute radiation syndromes from space radiation. The keystones of the NASA Program are five NASA Specialized Center's of Research (NSCOR) investigating space radiation risks. Other research is carried out through peer-reviewed individual investigations and in collaboration with the US Department of Energies Low-Dose Research Program. The Space Radiation Research Program has established the Risk Assessment Project to integrate data from the NSCOR s and other peer-reviewed research into quantitative projection models with the goals of steering research into data and scientific breakthroughs that will reduce the uncertainties in current risk projections and developing the scientific knowledge needed for future individual risk assessment approaches and biological countermeasure assessments or design. The NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory was created by the Program to simulate space radiation on the ground in support of the above research programs. New results from NSRL will be described.

Exploratory Advanced Research Program : Research Associates Program 2014

DOT National Transportation Integrated Search

2014-12-31

Since 1954, the National Research Council (NRC) has conducted the Research Associateship Program (RAP) in cooperation with sponsoring Federal laboratories and other approved participating research organizations. RAP provides highly skilled and exceed...

Exploratory Advanced Research Program : Research Associates Program 2016

DOT National Transportation Integrated Search

2017-02-01

Since 1954, the National Research Council (NRC) has conducted the Research Associateship Program (RAP) in cooperation with sponsoring Federal laboratories and other approved participating research organizations. RAP provides highly skilled and exceed...

Bully Prevention, Peer Mediation and Conflict Resolution: Impact of Prevention Programs on Reducing School Suspensions

ERIC Educational Resources Information Center

Frost, Alice M.

2012-01-01

Previous research examined various factors of program design, specific program curriculum, and student and faculty attitudes, but repeated studies and methodology questions have been raised with some of the research. Much of the research in the field has examined specific program effectiveness where the researcher is the author of the program or…

Characteristics of research tracks in dermatology residency programs: a national survey.

PubMed

Narala, Saisindhu; Loh, Tiffany; Shinkai, Kanade; Paravar, Taraneh

2017-12-15

Pursuing research is encouraged in dermatology residency programs. Some programs offer specific research or investigative tracks. Currently, there is little data on the structure or scope of research tracks in dermatology residency programs. An anonymous online survey was distributed to the Association of Professors of Dermatology listserve in 2016. Program directors of dermatology residency programs in the United States were asked to participate and 38 of the 95 program directors responded. The survey results confirmed that a 2+2 research track, which is two years of clinical training followed by two years of research, was the most common investigator trackmodel and may promote an academic career at the resident's home institution. Further studies will help determine the most effective research track models to promote long-term outcomes.

Designing and implementing an authentic science research program

NASA Astrophysics Data System (ADS)

Rosvally, Harry Edward, Jr.

Science research programs have become a popular elective course in high schools around the country. As the popularity of these programs grows, school districts need a guide by which to implement science research in their own schools. This study sought to provide this information by answering the following questions: (1) What are the most important features in existing research program models? (2) How do schools that have an existing research program define "success"? (3) How do different factors (i.e., budget, professional development, scheduling, recruitment effort, curriculum, and mentors) affect the scope and implementation of a research program? (4) Which features and factors support inclusiveness as a goal for a research program? (5) What kinds of indicators are appropriate for assessing the progress toward an inclusive science research program? After reviewing the literature, six sites with existing research programs were selected for participation in the study. Interviews with teachers and students were conducted during site visits. Interviews with mentors were conducted by telephone. Although the six models in this study were different from one another, there were common characteristics. Students conducted their own review of the literature. Upon completion of the actual research, students published or otherwise communicated their findings to the larger scientific community through regional and national competitions and non-competitive science symposia. This study was also able to identify significant elements that contribute to successful programs. These included: teacher selection; budget requirements; mentor qualities; recruitment and retention practices; and overall structure. As a result of the findings during the research, this study makes recommendations for the successful implementation of a research program.

Collaboration and Community Building in Summer Undergraduate Research Programs in the School of Earth Sciences at Stanford University

NASA Astrophysics Data System (ADS)

Nevle, R. J.; Watson Nelson, T.; Harris, J. M.; Klemperer, S. L.

2012-12-01

In 2012, the School of Earth Sciences (SES) at Stanford University sponsored two summer undergraduate research programs. Here we describe these programs and efforts to build a cohesive research cohort among the programs' diverse participants. The two programs, the Stanford School of Earth Sciences Undergraduate Research (SESUR) Program and Stanford School of Earth Sciences Summer Undergraduate Research in Geoscience and Engineering (SURGE) Program, serve different undergraduate populations and have somewhat different objectives, but both provide students with opportunities to work on strongly mentored yet individualized research projects. In addition to research, enrichment activities co-sponsored by both programs support the development of community within the combined SES summer undergraduate research cohort. Over the course of 6 to 9 months, the SESUR Program engages Stanford undergraduates, primarily rising sophomores and juniors, with opportunities to deeply explore Earth sciences research while learning about diverse areas of inquiry within SES. Now in its eleventh year, the SESUR experience incorporates the breadth of the scientific endeavor: finding an advisor, proposal writing, obtaining funding, conducting research, and presenting results. Goals of the SESUR program include (1) providing a challenging and rewarding research experience for undergraduates who wish to explore the Earth sciences; (2) fostering interdisciplinary study in the Earth sciences among the undergraduate population; and (3) encouraging students to major or minor in the Earth sciences and/or to complete advanced undergraduate research in one of the departments or programs within SES. The SURGE Program, now in its second year, draws high performing students, primarily rising juniors and seniors, from 14 colleges and universities nationwide, including Stanford. Seventy percent of SURGE students are from racial/ethnic backgrounds underrepresented in STEM fields, and approximately one-third are the first in their families to attend college. For eight weeks, SURGE scholars conduct independent research with the guidance of faculty, research group mentors, and program assistants. The primary objectives of the SURGE program are to (1) provide undergraduates with a research experience in SES; (2) prepare undergraduates for the process of applying to graduate school; (3) introduce undergraduates to career opportunities in the geosciences and engineering; and (4) increase diversity in SES graduate programs. Independent research, network building, and intense mentoring culminate in a final oral and poster symposium. SESUR and SURGE scholars jointly participate in enrichment activities including faculty research seminars; career, graduate school, and software training workshops; GRE preparation classes; and geoscience-oriented field trips. Interaction among our students takes place through both research and enrichment activities, creating a critical mass of undergraduate scholars and promoting community development. Pre- and post-program surveys indicate that the overall goals of both programs are being achieved.

Academic research opportunities at the National Geospatial-Intelligence Agency(NGA)

NASA Astrophysics Data System (ADS)

Loomer, Scott A.

2006-05-01

The vision of the National Geospatial-Intelligence Agency (NGA) is to "Know the Earth...Show the Way." To achieve this vision, the NGA provides geospatial intelligence in all its forms and from whatever source-imagery, imagery intelligence, and geospatial data and information-to ensure the knowledge foundation for planning, decision, and action. Academia plays a key role in the NGA research and development program through the NGA Academic Research Program. This multi-disciplinary program of basic research in geospatial intelligence topics provides grants and fellowships to the leading investigators, research universities, and colleges of the nation. This research provides the fundamental science support to NGA's applied and advanced research programs. The major components of the NGA Academic Research Program are: *NGA University Research Initiatives (NURI): Three-year basic research grants awarded competitively to the best investigators across the US academic community. Topics are selected to provide the scientific basis for advanced and applied research in NGA core disciplines. *Historically Black College and University - Minority Institution Research Initiatives (HBCU-MI): Two-year basic research grants awarded competitively to the best investigators at Historically Black Colleges and Universities, and Minority Institutions across the US academic community. *Intelligence Community Post-Doctoral Research Fellowships: Fellowships providing access to advanced research in science and technology applicable to the intelligence community's mission. The program provides a pool of researchers to support future intelligence community needs and develops long-term relationships with researchers as they move into career positions. This paper provides information about the NGA Academic Research Program, the projects it supports and how researchers and institutions can apply for grants under the program. In addition, other opportunities for academia to engage with NGA through training programs and recruitment are discussed.

A Survey of Campus Coordinators of Undergraduate Research Programs

ERIC Educational Resources Information Center

Hensley, Merinda Kaye; Shreeves, Sarah L.; Davis-Kahl, Stephanie

2015-01-01

Interest in supporting undergraduate research programs continues to grow within academic librarianship. This article presents how undergraduate research program coordinators perceive and value library support of their programs. Undergraduate research coordinators from a variety of institutions were surveyed on which elements of libraries and…

Implementation of a volunteer university student research assistant program in an emergency department: the nuts and bolts for success.

PubMed

Steadman, Patrick E; Crudden, Johanna; Boutis, Kathy

2015-09-01

Prospective research studies often advance clinical practice in the emergency department (ED), but they can be costly and difficult to perform. In this report, we describe the implementation of a volunteer university student research assistant program that provides students exposure to medicine and clinical research while simultaneously increasing the capacity of an ED's research program. This type of program provides 15 hours per day of research assistant coverage for patient screening and enrolment for minimal risk research studies, and screening for higher risk studies. The latter is true without the added burden or costs of co-administering university course credit or pay for service, which are common features of most of these types of programs currently in operation. We have shown that our volunteer-based program is effective for an ED's research success as well as for its student participants. For other EDs interested in adopting similar programs, we provide the details on how to get such a program started and highlight the structure and non-monetary incentives that facilitate a program's ongoing success.

Summer Research Program (1992). Graduate Student Research Program (GSRP) Reports. Volume 8. Phillips Laboratory.

DTIC Science & Technology

1992-12-28

Research Program Starfire Optical Range, Phillips Laboratory /LITE Kirtland Air Force Base, Albuquerque, NM 87117 Sponsored by: Air ... Phillips Laboratory Sponsored by: Air Force Office of Scientific Research Kirtland Air Force Base, Albuquerque, New Mexico September, 1992 18-1 PROGRESS...Report for: Summer Research Program Phillips Laboratory Sponsored by: Air

1997 Graduate Student Researchers Program

NASA Technical Reports Server (NTRS)

1996-01-01

In 1980, NASA initiated the Graduate Student Research Program (GSRP) to cultivate additional research ties to the academic community and to support a culturally diverse group of students pursuing advanced degrees in science and engineering. Eligibility requirements for this program are described, and program administrators are listed. Research areas are detailed for NASA Headquarters and all Research and Flight Centers.

The undergraduate research fellows program: a unique model to promote engagement in research.

PubMed

Vessey, Judith A; DeMarco, Rosanna F

2008-01-01

Well-educated nurses with research expertise are needed to advance evidence-based nursing practice. A primary goal of undergraduate nursing curricula is to create meaningful participatory experiences to help students develop a research skill set that articulates with rapid career advancement of gifted, young graduates interested in nursing research and faculty careers. Three research enrichment models-undergraduate honors programs, research assistant work-for-hire programs, and research work/mentorship programs-to be in conjunction with standard research content are reviewed. The development and implementation of one research work/mentorship program, the Boston College undergraduate research fellows program (UGRF), is explicated. This process included surveying previous UGRFs followed by creating a retreat and seminars to address specific research skill sets. The research skill sets included (a) how to develop a research team, (b) accurate data retrieval, (c) ethical considerations, (d) the research process, (e) data management, (f) successful writing of abstracts, and (g) creating effective poster presentations. Outcomes include evidence of involvement in research productivity and valuing of evidenced-based practice through the UGRF mentorship process with faculty partners.

42 CFR 68a.5 - Who is ineligible to participate?

Code of Federal Regulations, 2010 CFR

2010-10-01

..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR...: Physicians Shortage Area Scholarship Program, National Research Service Award Program, Public Health Service...) Professions Scholarship Program, Indian Health Service Scholarship Program, and the NIH AIDS Research Loan...

LDRD 2013 Annual Report: Laboratory Directed Research and Development Program Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bookless, W.

This LDRD project establishes a research program led by Jingguang Chen, who has started a new position as a Joint Appointee between BNL and Columbia University as of FY2013. Under this project, Dr. Chen will establish a new program in catalysis science at BNL and Columbia University. The LDRD program will provide initial research funding to start research at both BNL and Columbia. At BNL, Dr. Chen will initiate laboratory research, including hiring research staff, and will collaborate with the existing BNL catalysis and electrocatalysis research groups. At Columbia, a subcontract to Dr. Chen will provide startup funding for hismore » laboratory research, including initial graduate student costs. The research efforts will be linked under a common Catalysis Program in Sustainable Fuels. The overall impact of this project will be to strengthen the BNL catalysis science program through new linked research thrusts and the addition of an internationally distinguished catalysis scientist.« less

A Summer Research Training Program to Foster PharmD Students' Interest in Research

PubMed Central

Moore, Mariellen J.; Shin, Jaekyu; Frye, Reginald F.

2008-01-01

Objectives To establish and assess the effectiveness of a 10-week summer research program on increasing doctor of pharmacy (PharmD) students' interest in research, particularly as it related to future career choices. Design Survey instruments were sent to 25 participants who had completed the research program in the summer of 2004, 2005, or 2006 to assess their satisfaction with the program and its influence on their career choices after graduation. Assessment Respondents reported a high degree of satisfaction with the program, indicating that the program allowed them to determine their suitability for a career in research, and 55% reported their intention to pursue additional research training. Conclusion A brief introduction to the clinical research environment helped pharmacy students understand the clinical sciences and careers in research. The introduction increased the likelihood of students pursuing a research career path after obtaining their PharmD degree. PMID:18483591

Aeroacoustics Research Program in JIAFS

NASA Technical Reports Server (NTRS)

Myers, Michael K.

2000-01-01

This paper presents a final report on Aeroacoustics Research Program in JIAFS (Joint Institute For Advancement of Flight Sciences). The objectives of the program were to conduct research at the NASA Langley Research Center and to provide a comprehensive education program at the Center leading to advanced degrees in aeroacoustics.

78 FR 20466 - National Institutes of Health Loan Repayment Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-05

... (Extramural LRPs). The Intramural LRPs include the Loan Repayment Program for Research with Respect to Acquired Immune Deficiency Syndrome (or AIDS Research LRP); Loan Repayment Program for General Research (or General Research LRP), which includes a program for the Accreditation Council for Graduate Medical...

30 CFR 402.6 - Water-Resources Research Program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM... Water-Resources Research Program. (a) Subject to the availability of appropriated funds, the Water...

30 CFR 402.6 - Water-Resources Research Program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM... Water-Resources Research Program. (a) Subject to the availability of appropriated funds, the Water...

30 CFR 402.6 - Water-Resources Research Program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM... Water-Resources Research Program. (a) Subject to the availability of appropriated funds, the Water...

30 CFR 402.6 - Water-Resources Research Program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM... Water-Resources Research Program. (a) Subject to the availability of appropriated funds, the Water...

30 CFR 402.6 - Water-Resources Research Program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM... Water-Resources Research Program. (a) Subject to the availability of appropriated funds, the Water...

Center for Prostate Disease Research

MedlinePlus

... 2017 Cancer Statistics programs Clinical Research Program Synopsis Leadership Multi-Disciplinary Clinic Staff Listing 2017 Cancer Statistics Basic Science Research Program Synopsis Leadership Gene Expression Data Research Achievements Staff Listing Lab ...

Army Medical Research and Materiel Command Resident Research Associateship Program

DTIC Science & Technology

2017-05-01

Award Number: W81XWH-12-2-0033 TITLE: Army Medical Research & Materiel Command Resident Research Associateship Program PRINCIPAL INVESTIGATOR...PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for Public...SUBTITLE NRC/AMRMC Resident Research Associateship Program 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-12-2-0033 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S

Improving Defense Health Program Medical Research Processes

DTIC Science & Technology

2017-08-08

needed for DHP medical research , such as the Army’s Clinical and Translational Research Program Office, 38 the Navy’s Research Methods Training Program... research stated, “key infrastructure for a learning health system will encompass three core elements: data networks, methods , and workforce.” 221 A 2012... Research Methods Training Program, 132 which will be further discussed in Appendix D.2. AIR FORCE Air Force Instruction 40-402, Protection of

The Precision Medicine Initiative's All of Us Research Program: an agenda for research on its ethical, legal, and social issues.

PubMed

Sankar, Pamela L; Parker, Lisa S

2017-07-01

The Precision Medicine Initiative (PMI) is an innovative approach to developing a new model of health care that takes into account individual differences in people's genes, environments, and lifestyles. A cornerstone of the initiative is the PMI All of Us Research Program (formerly known as PMI-Cohort Program) which will create a cohort of 1 million volunteers who will contribute their health data and biospecimens to a centralized national database to support precision medicine research. The PMI All of US Research Program is the largest longitudinal study in the history of the United States. The designers of the Program anticipated and addressed some of the ethical, legal, and social issues (ELSI) associated with the initiative. To date, however, there is no plan to call for research regarding ELSI associated with the Program-PMI All of Us program. Based on analysis of National Institutes of Health (NIH) funding announcements for the PMI All of Us program, we have identified three ELSI themes: cohort diversity and health disparities, participant engagement, and privacy and security. We review All of Us Research Program plans to address these issues and then identify additional ELSI within each domain that warrant ongoing investigation as the All of Us Research Program develops. We conclude that PMI's All of Us Research Program represents a significant opportunity and obligation to identify, analyze, and respond to ELSI, and we call on the PMI to initiate a research program capable of taking on these challenges.Genet Med advance online publication 01 December 2016.

[Development of advanced educational programs, including research programs, for undergraduate students in National Universities: the facts in 2010].

PubMed

Kurosaki, Yuji; Tomioka, Yoshihisa; Santa, Tomofumi; Kitamura, Yoshihisa

2012-01-01

This article summarizes detailed facts obtained from the questionnaire conducted in 2010 at about 14 National Universities on the topic of "Research programs and advanced educational programs for undergraduate students". The contents of the questionnaire included: (1) Research programs based on the coalition of university and hospital and/or community pharmacy, other Graduate Schools, such as School of Medicine etc., and the University Hospital, (2) Educational systems for the achievement of research programs and their research outcomes, (3) Research programs based on pharmacist practices, (4) Ongoing advanced educational programs for undergraduate students, taking advantage of the coalition with Graduate School, School of Medicine (and Dentistry), and University Hospital. Some of the advanced educational programs outlined in this questionnaire will be carried out by our group in the coming years and the educational benefits together with associated problems shall as well be clarified. This approach will be informative for the development of the leader-oriented pharmacist programs for the college of Pharmacy.

Photovoltaic Research in the Small Business Innovative Research Program

NASA Astrophysics Data System (ADS)

Bower, Ward I.; Bulawka, Alec

1997-02-01

The Small Business Innovative Research Program (SBIR) is currently authorized to be funded through September 30, 2000. The National Photovoltaics Program is a contributor to the Department of Energy (DOE) SBIR program. The small business photovoltaic industry has been benefiting from the SBIR program through awards that have funded basic research, new processes and products that have PV and other commercial applications. This paper provides information on SBIR opportunities, selected details of the SBIR program, statistics from the 1995 and 1996 DOE SBIR program, and methods for improving PV industry participation and success in the SBIR program.

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7104 - Contracts under the Small Business Innovation Research (SBIR) Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Business Innovation Research (SBIR) Program. 227.7104 Section 227.7104 Federal Acquisition Regulations... Innovation Research (SBIR) Program. (a) Use the clause at 252.227-7018, Rights in Noncommercial Technical Data and Computer Software—Small Business Innovation Research (SBIR) Program, when technical data or...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7104 - Contracts under the Small Business Innovation Research (SBIR) Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Business Innovation Research (SBIR) Program. 227.7104 Section 227.7104 Federal Acquisition Regulations... Innovation Research (SBIR) Program. (a) Use the clause at 252.227-7018, Rights in Noncommercial Technical Data and Computer Software—Small Business Innovation Research (SBIR) Program, when technical data or...

48 CFR 227.7104 - Contracts under the Small Business Innovation Research (SBIR) Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Business Innovation Research (SBIR) Program. 227.7104 Section 227.7104 Federal Acquisition Regulations... Innovation Research (SBIR) Program. (a) Use the clause at 252.227-7018, Rights in Noncommercial Technical Data and Computer Software—Small Business Innovation Research (SBIR) Program, when technical data or...

34 CFR 662.1 - What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Research Abroad Fellowship Program? 662.1 Section 662.1 Education Regulations of the Offices of the... DOCTORAL DISSERTATION RESEARCH ABROAD FELLOWSHIP PROGRAM General § 662.1 What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program? (a) The Fulbright-Hays Doctoral Dissertation...

34 CFR 662.1 - What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Research Abroad Fellowship Program? 662.1 Section 662.1 Education Regulations of the Offices of the... DOCTORAL DISSERTATION RESEARCH ABROAD FELLOWSHIP PROGRAM General § 662.1 What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program? (a) The Fulbright-Hays Doctoral Dissertation...

34 CFR 662.1 - What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Research Abroad Fellowship Program? 662.1 Section 662.1 Education Regulations of the Offices of the... DOCTORAL DISSERTATION RESEARCH ABROAD FELLOWSHIP PROGRAM General § 662.1 What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program? (a) The Fulbright-Hays Doctoral Dissertation...

34 CFR 662.1 - What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Research Abroad Fellowship Program? 662.1 Section 662.1 Education Regulations of the Offices of the... DOCTORAL DISSERTATION RESEARCH ABROAD FELLOWSHIP PROGRAM General § 662.1 What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program? (a) The Fulbright-Hays Doctoral Dissertation...

34 CFR 662.1 - What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Research Abroad Fellowship Program? 662.1 Section 662.1 Education Regulations of the Offices of the... DOCTORAL DISSERTATION RESEARCH ABROAD FELLOWSHIP PROGRAM General § 662.1 What is the Fulbright-Hays Doctoral Dissertation Research Abroad Fellowship Program? (a) The Fulbright-Hays Doctoral Dissertation...

Keeping Clinicians in Clinical Research: The Clinical Research/Reproductive Scientist Training Program

PubMed Central

Armstrong, Alicia Y.; DeCherney, Alan; Leppert, Phyllis; Rebar, Robert; Maddox, Yvonne T.

2009-01-01

In recent years the need for translational and clinical research has increased while the number of physicians involved in clinical research has diminished. There is clearly a need for formalized academic training in the quantitative and methodological principles of clinical research in reproductive medicine. The Clinical Research/Reproductive Scientist Training Program (CREST), a program supported by the National Institute of Child Health and Human Development, the Clinical Research Training Program (CRTP) at Duke University, and the American Society for Reproductive Medicine,(ASRM) meets this existing need. In addition, this program is specifically designed for physicians in private or academic clinical practice in reproductive medicine. Innovative programs such as CREST encourage the practicing physician to engage in clinical research while maintaining an active role in clinical practice. Participants in the program receive didactic on-line training from the CRTP, attend intensive weekend seminars at the National Institutes of Health (NIH) and CREST seminars at the annual meeting of ASRM. Successful participants in the program receive a Certificate in Clinical Research from the CRTP. The program’s goal is to provide practicing physicians with the tools and research credentials that will facilitate collaborations with investigators involved in large clinical trials. PMID:19144332

Summer Research Training for Medical Students: Impact on Research Self‐Efficacy

PubMed Central

Black, Michelle L.; Curran, Maureen C.; Golshan, Shahrokh; Daly, Rebecca; Depp, Colin; Kelly, Carolyn

2013-01-01

Abstract There is a well‐documented shortage of physician researchers, and numerous training programs have been launched to facilitate development of new physician scientists. Short‐term research training programs are the most practical form of research exposure for most medical students, and the summer between their first and second years of medical school is generally the longest period they can devote solely to research. The goal of short‐term training programs is to whet the students’ appetite for research and spark their interest in the field. Relatively little research has been done to test the effectiveness of short‐term research training programs. In an effort to examine short‐term effects of three different NIH‐funded summer research training programs for medical students, we assessed the trainees’ (N = 75) research self‐efficacy prior to and after the programs using an 11‐item scale. These hands‐on training programs combined experiential, didactic, and mentoring elements. The students demonstrated a significant increase in their self‐efficacy for research. Trainees’ gender, ranking of their school, type of research, and specific content of research project did not predict improvement. Effect sizes for different types of items on the scale varied, with the largest gain seen in research methodology and communication of study findings. PMID:24330695

Laboratory Directed Research and Development Program FY2016 Annual Summary of Completed Projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

ORNL FY 2016 Annual Summary of Laboratory Directed Research and Development Program (LDRD) Completed Projects. The Laboratory Directed Research and Development (LDRD) program at ORNL operates under the authority of DOE Order 413.2C, “Laboratory Directed Research and Development” (October 22, 2015), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. The LDRD program funds are obtained through a charge to all Laboratory programs. ORNL reports its status to DOE in March of each year.

NASA's new university engineering space research programs

NASA Technical Reports Server (NTRS)

Sadin, Stanley R.

1988-01-01

The objective of a newly emerging element of NASA's university engineering programs is to provide a more autonomous element that will enhance and broaden the capabilities in academia, enabling them to participate more effectively in the U.S. civil space program. The programs utilize technical monitors at NASA centers to foster collaborative arrangements, exchange of personnel, and the sharing of facilities between NASA and the universities. The elements include: the university advanced space design program, which funds advanced systems study courses at the senior and graduate levels; the university space engineering research program that supports cross-disciplinary research centers; the outreach flight experiments program that offers engineering research opportunities to universities; and the planned university investigator's research program to provide grants to individuals with outstanding credentials.

NASA's Microgravity Research Program

NASA Technical Reports Server (NTRS)

Woodard, Dan R. (Editor); Henderson, Robin N. (Technical Monitor)

2000-01-01

The Fiscal Year 1999 Annual Report describes key elements of the NASA Microgravity Research Program. The Program's goals, approach taken to achieve those goals, and program resources are summarized. A review of the Program's status at the end of FY1999 and highlights of the ground-and-flight research are provided.

Research Programs Constituting U.S. Participation in the International Biological Program.

ERIC Educational Resources Information Center

National Academy of Sciences--National Research Council, Washington, DC. Div. of Biology and Agriculture.

The United States contribution to the International Biological Program, which aims to understand more clearly the interrelationships within ecosystems, is centered on multidisciplinary research programs investigating the biological basis of ecological productivity and human welfare. Integrated research programs have been established for the…

77 FR 68138 - Office of the Director, National Institutes of Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... Program Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds; 93.232, Loan Repayment Program for Research Generally... Loan Repayment Program; 93.187, Undergraduate Scholarship Program for Individuals from Disadvantaged...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uhle, Maria

These funds were transferred from DOE to NSF as DOE's contribution to the U.S. Global Change Research Program in support of 4 internationalnactivities/programs as approved by the U.S. Global Change Research Program on 14 March 2014. The programs are the International Geosphere-Biosphere Programme, the DIVERSITAS programme, and the World Climate Research Program. All program awards ended as of 09-23-2015.

Implementation activities for the Wisconsin Highway Research Program (WHRP).

DOT National Transportation Integrated Search

2010-03-01

The Wisconsin Highway Research Program (WHRP) Steering Committee commissioned an implementation pilot : program in 2006 to facilitate the incorporation of research results into the programs, standards, and processes of : the Wisconsin Department of T...

Glaucoma Symptoms

MedlinePlus

... Alzheimer’s Disease Research Program Macular Degeneration Research Program National Glaucoma Research Program Molecular Neurodegeneration ... Foundation BrightFocus Foundation 22512 Gateway Center Drive Clarksburg, MD ...

77 FR 37022 - Disability and Rehabilitation Research Projects and Centers Program; Rehabilitation Engineering...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

...; Rehabilitation Engineering Research Centers AGENCY: Office of Special Education and Rehabilitative Services... Rehabilitation Research Projects and Centers Program--Rehabilitation Engineering Research Centers (RERC). SUMMARY... amended (Rehabilitation Act). Rehabilitation Engineering Research Centers Program (RERCs) The purpose of...

76 FR 37085 - Applications for New Awards; Rehabilitation Engineering Research Centers (RERCs)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-24

... DEPARTMENT OF EDUCATION Applications for New Awards; Rehabilitation Engineering Research Centers...)--Disability and Rehabilitation Research Projects and Centers Program--Rehabilitation Engineering Research... (Rehabilitation Act). Rehabilitation Engineering Research Centers Program (RERCs) The purpose of the RERC program...

Research Ethics Education in Post-Graduate Medical Curricula in I.R. Iran.

PubMed

Nikravanfard, Nazila; Khorasanizadeh, Faezeh; Zendehdel, Kazem

2017-08-01

Research ethics training during post-graduate education is necessary to improve ethical standards in the design and conduct of biomedical research. We studied quality and quantity of research ethics training in the curricula of post-graduate programs in the medical science in I.R. Iran. We evaluated curricula of 125 post-graduate programs in medical sciences in I.R. Iran. We qualitatively studied the curricula by education level, including the Master and PhD degrees and analyzed the contents and the amount of teaching allocated for ethics training in each curriculum. We found no research ethics training in 72 (58%) of the programs. Among the 53 (42%) programs that considered research ethics training, only 17 programs had specific courses for research ethics and eight of them had detailed topics on their courses. The research ethics training was optional in 25% and mandatory in 76% of the programs. Post-graduate studies that were approved in the more recent years had more attention to the research ethics training. Research ethics training was neglected in most of the medical post-graduate programs. We suggest including sufficient amount of mandatory research ethics training in Master and PhD programs in I.R. Iran. Further research about quality of research ethics training and implementation of curricula in the biomedical institutions is warranted. © 2016 John Wiley & Sons Ltd.

The NCI Community Oncology Research Program: what every clinician needs to know.

PubMed

McCaskill-Stevens, Worta; Lyss, Alan P; Good, Marge; Marsland, Thomas; Lilenbaum, Rogerio

2013-01-01

Research in the community setting is essential for the translation of advances in cancer research into practice and improving cancer care for all populations. The National Cancer Institute is proposing a new community-based program, NCI Community Oncology Research Program (NCORP), which is the alignment of two existing programs, the Community Clinical Oncology Program, Minority-Based Community Clinical Oncology Program, and their Research Bases, and the National Cancer Institute's Community Cancer Centers Program. NCROP will support cancer control, prevention, treatment, and screening clinical trials and expand its research scope to include cancer care delivery research. Cancer disparities research will be integrated into studies across the continuum of NCORP research. Input from current NCI-funded community investigators provides critical insight into the challenges faced by oncology practices within various organizational structures. Furthermore, these investigators identify the resources, both administrative and clinical, that will be required in the community setting to support cancer care delivery research and to meet the requirements for a new generation of clinical research. The American Society for Clinical Oncology (ASCO) has initiated a forum to focus on the conduct of clinical research in the community setting. Resources are being developed to help practices in managing cancer care in community settings.

Research peer exchange, 2017 : final report.

DOT National Transportation Integrated Search

2017-04-01

State DOT research programs are applied research programs, historically focused on materials and structures. In the last several years, the pace and nature of FDOTs research program have evolved. Increased emphasis on implementation and performanc...

NASA Microgravity Research Program

NASA Technical Reports Server (NTRS)

Woodard, Dan

1999-01-01

The Fiscal Year 1998 Annual Report describes key elements of the NASA Microgravity Research Program. The Program's goals, approach taken to achieve those goals, and program resources are summarized. A review of the Program's status at the end of FY1998 and highlights of the ground- and-flight-based research are provided.

Research Issues and Language Program Direction. Issues in Language Program Direction: A Series of Annual Volumes.

ERIC Educational Resources Information Center

Heilenman, L. Kathy, Ed.

This collection of papers is divided into two parts. After "Introduction" (L. Kathy Heilenman), Part 1, "Research and Language Program Directors: The Relationship," includes "Research Domains and Language Program Direction" (Bill VanPatten); "Language Program Direction and the Modernist Agenda" (Celeste…

A Systematic Review of Extramural Presentations and Publications from Pharmacy Student Research Programs

PubMed Central

Martin, Jennifer; Worede, Leah; Islam, Sameer

2016-01-01

Objective. To conduct a systematic review of reports of pharmacy student research programs that describes the programs and resulting publications or presentations. Methods. To be eligible for the review, reports had to be in English and indicate that students were required to collect, analyze data, and report or present findings. The outcome variables were extramural posters/presentations and publications. Results. Database searches resulted in identification of 13 reports for 12 programs. Two-thirds were reports of projects required for a course or for graduation, and the remaining third were elective (participation was optional). Extramural posters resulted from 75% of the programs and publications from 67%. Conclusion. Although reporting on the outcomes of student research programs is limited, three-quarters of the programs indicated that extramural presentations, publications, or both resulted from student research. Additional research is needed to identify relevant outcomes of student research programs in pharmacy. PMID:27667837

A Systematic Review of Extramural Presentations and Publications from Pharmacy Student Research Programs.

PubMed

Slack, Marion K; Martin, Jennifer; Worede, Leah; Islam, Sameer

2016-08-25

Objective. To conduct a systematic review of reports of pharmacy student research programs that describes the programs and resulting publications or presentations. Methods. To be eligible for the review, reports had to be in English and indicate that students were required to collect, analyze data, and report or present findings. The outcome variables were extramural posters/presentations and publications. Results. Database searches resulted in identification of 13 reports for 12 programs. Two-thirds were reports of projects required for a course or for graduation, and the remaining third were elective (participation was optional). Extramural posters resulted from 75% of the programs and publications from 67%. Conclusion. Although reporting on the outcomes of student research programs is limited, three-quarters of the programs indicated that extramural presentations, publications, or both resulted from student research. Additional research is needed to identify relevant outcomes of student research programs in pharmacy.

Enhancing pediatric residents’ scholar role: the development of a Scholarly Activity Guidance and Evaluation program

PubMed Central

Pound, Catherine M.; Moreau, Katherine A.; Ward, Natalie; Eady, Kaylee; Writer, Hilary

2015-01-01

Background Research training is essential to the development of well-rounded physicians. Although many pediatric residency programs require residents to complete a research project, it is often challenging to integrate research training into educational programs. Objective We aimed to develop an innovative research program for pediatric residents, called the Scholarly Activity Guidance and Evaluation (SAGE) program. Methods We developed a competency-based program which establishes benchmarks for pediatric residents, while providing ongoing academic mentorship. Results Feedback from residents and their research supervisors about the SAGE program has been positive. Preliminary evaluation data have shown that all final-year residents have met or exceeded program expectations. Conclusions By providing residents with this supportive environment, we hope to influence their academic career paths, increase their research productivity, promote evidence-based practice, and ultimately, positively impact health outcomes. PMID:26059213

MINDFULNESS GOES TO SCHOOL: THINGS LEARNED (SO FAR) FROM RESEARCH AND REAL-WORLD EXPERIENCES.

PubMed

Semple, Randye J; Droutman, Vita; Reid, Brittany Ann

2017-01-01

Mindfulness-based curricula are being implemented in K-12 schools across the nation. Many of these programs, although well-considered and implemented, have little or no research support for their effectiveness. Recognizing the paucity of published research in this area, a sampling of school-based programs currently being implemented in the schools is reviewed. The programs reviewed are Inner Explorer, Master Mind and Moment Program, Mindfulness and Mind-Body Skills for Children, Mindful Schools, Resilient Kids, Still Quiet Place, Stress Reduction and Mindfulness Curriculum and Mindful Moment , and Wellness and Resilience Program . We offer a summary of research support for each program and discussion of unpublished, mostly qualitative indicators of feasibility, acceptability, efficacy, and effectiveness. Strengths and limitations of each program are described, along with suggestions for bolstering informative and useful research. We encourage researchers, educators, and mindfulness practitioners to work collaboratively to conduct rigorous program evaluations.

MINDFULNESS GOES TO SCHOOL: THINGS LEARNED (SO FAR) FROM RESEARCH AND REAL-WORLD EXPERIENCES

PubMed Central

Semple, Randye J.; Droutman, Vita; Reid, Brittany Ann

2016-01-01

Mindfulness-based curricula are being implemented in K-12 schools across the nation. Many of these programs, although well-considered and implemented, have little or no research support for their effectiveness. Recognizing the paucity of published research in this area, a sampling of school-based programs currently being implemented in the schools is reviewed. The programs reviewed are Inner Explorer, Master Mind and Moment Program, Mindfulness and Mind-Body Skills for Children, Mindful Schools, Resilient Kids, Still Quiet Place, Stress Reduction and Mindfulness Curriculum and Mindful Moment, and Wellness and Resilience Program. We offer a summary of research support for each program and discussion of unpublished, mostly qualitative indicators of feasibility, acceptability, efficacy, and effectiveness. Strengths and limitations of each program are described, along with suggestions for bolstering informative and useful research. We encourage researchers, educators, and mindfulness practitioners to work collaboratively to conduct rigorous program evaluations. PMID:28458403

Summaries of FY 1993 Engineering Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-09-01

This report documents the BES Engineering Research Program for fiscal year 1993; it provides a summary for each of the program projects in addition to a brief program overview. The report is intended to provide staff of Congressional committees, other executive departments, and other DOE offices with substantive program information so as to facilitate governmental overview and coordination of Federal research programs. Of equal importance, its availability facilitates communication of program information to interested research engineers and scientists. The organizational chart for the DOE Office of Energy Research (OER) on the next page delineates the six Divisions within the OERmore » Office of Basic Energy Sciences (BES). Each BES Division administers basic, mission oriented research programs in the area indicated by its title. The BES Engineering Research Program is one such program; it is administered by the Engineering and Geosciences Division of BES. In preparing this report we asked the principal investigators to submit summaries for their projects that were specifically applicable to fiscal year 1993. The summaries received have been edited if necessary.« less

Lewis' Educational and Research Collaborative Intership Program Grant Closeout Report

NASA Technical Reports Server (NTRS)

2003-01-01

The Lewis' Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships and 10 or 12-week fellowships for undergraduate/graduate students and secondary school teachers. Approximately 130 interns are selected to participate in this program each year and begin arriving the second week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, lectures and short courses. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds.

Integration of NASA Research into Undergraduate Education in Math, Science, Engineering and Technology at North Carolina A&T State University

NASA Technical Reports Server (NTRS)

Monroe, Joseph; Kelkar, Ajit

2003-01-01

The NASA PAIR program incorporated the NASA-Sponsored research into the undergraduate environment at North Carolina Agricultural and Technical State University. This program is designed to significantly improve undergraduate education in the areas of mathematics, science, engineering, and technology (MSET) by directly benefiting from the experiences of NASA field centers, affiliated industrial partners and academic institutions. The three basic goals of the program were enhancing core courses in MSET curriculum, upgrading core-engineering laboratories to compliment upgraded MSET curriculum, and conduct research training for undergraduates in MSET disciplines through a sophomore shadow program and through Research Experience for Undergraduates (REU) programs. Since the inception of the program nine courses have been modified to include NASA related topics and research. These courses have impacted over 900 students in the first three years of the program. The Electrical Engineering circuit's lab is completely re-equipped to include Computer controlled and data acquisition equipment. The Physics lab is upgraded to implement better sensory data acquisition to enhance students understanding of course concepts. In addition a new instrumentation laboratory in the department of Mechanical Engineering is developed. Research training for A&T students was conducted through four different programs: Apprentice program, Developers program, Sophomore Shadow program and Independent Research program. These programs provided opportunities for an average of forty students per semester.

The DOE Program Guide for Universities and Other Research Groups. Part I - DOE Research and Development Programs. Part II - DOE Procurement and Assistance Policies/Procedures.

ERIC Educational Resources Information Center

Department of Energy, Washington, DC. Procurement and Contracts Management Directorate.

This guide is intended to orient research organizations interested in establishing a program relationship with the United States Department of Energy (DOE). The publication is divided into two parts. Part I describes DOE research and development programs, summarizes budget data, and lists contact persons for DOE programs. In addition, this section…

78 FR 34901 - Final Priority; National Institute on Disability and Rehabilitation Research-Advanced...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... Institute on Disability and Rehabilitation Research--Advanced Rehabilitation Research Training Program... priority for the Advanced Rehabilitation Research Training (ARRT) program under the Disability and Rehabilitation Research Projects and Centers Program administered by the National Institute on Disability and...

Assessment team report on flight-critical systems research at NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Siewiorek, Daniel P. (Compiler); Dunham, Janet R. (Compiler)

1989-01-01

The quality, coverage, and distribution of effort of the flight-critical systems research program at NASA Langley Research Center was assessed. Within the scope of the Assessment Team's review, the research program was found to be very sound. All tasks under the current research program were at least partially addressing the industry needs. General recommendations made were to expand the program resources to provide additional coverage of high priority industry needs, including operations and maintenance, and to focus the program on an actual hardware and software system that is under development.

Summer Research Program (1992). Summer Faculty Research Program (SFRP) Reports. Volume 5A. Wright Laboratory

DTIC Science & Technology

1992-12-01

1992 6-~1 SOME RESULTS IN MACIIINE- LEARNING Mike Breen Assistant Professor Department of Mathematics Tennessee Technological Universitv Abstract The...Research Laboratory; Wilford Hall Medical Center 12 High School Apprenticeship Program Reports: Armstrong Laboratory 13 High School Apprenticeship ...Program Reports: Phillips Laboratory 14 High School Apprenticeship Program Reports: Rome Laboratory 15 High School Apprenticeship Program Reports

SU-E-T-565: RAdiation Resistance of Cancer CElls Using GEANT4 DNA: RACE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perrot, Y; Payno, H; Delage, E

2014-06-01

Purpose: The objective of the RACE project is to develop a comparison between Monte Carlo simulation using the Geant4-DNA toolkit and measurements of radiation damage on 3D melanoma and chondrosarcoma culture cells coupled with gadolinium nanoparticles. We currently expose the status of the developments regarding simulations. Methods: Monte Carlo studies are driven using the Geant4 toolkit and the Geant4-DNA extension. In order to model the geometry of a cell population, the opensource CPOP++ program is being developed for the geometrical representation of 3D cell populations including a specific cell mesh coupled with a multi-agent system. Each cell includes cytoplasm andmore » nucleus. The correct modeling of the cell population has been validated with confocal microscopy images of spheroids. The Geant4 Livermore physics models are used to simulate the interactions of a 250 keV X-ray beam and the production of secondaries from gadolinium nanoparticles supposed to be fixed on the cell membranes. Geant4-DNA processes are used to simulate the interactions of charged particles with the cells. An atomistic description of the DNA molecule, from PDB (Protein Data Bank) files, is provided by the so-called PDB4DNA Geant4 user application we developed to score energy depositions in DNA base pairs and sugar-phosphate groups. Results: At the microscopic level, our simulations enable assessing microscopic energy distribution in each cell compartment of a realistic 3D cell population. Dose enhancement factors due to the presence of gadolinium nanoparticles can be estimated. At the nanometer scale, direct damages on nuclear DNA are also estimated. Conclusion: We successfully simulated the impact of direct radiations on a realistic 3D cell population model compatible with microdosimetry calculations using the Geant4-DNA toolkit. Upcoming validation and the future integration of the radiochemistry module of Geant4-DNA will propose to correlate clusters of ionizations with in vitro experiments. All those developments will be released publicly. This work was supported by grants from Plan Cancer 2009-2013 French national initiative managed by INSERM (Institut National de la Sante et de la Recherche Medicale)« less

Evaluation of WYDOT's research center and research program.

DOT National Transportation Integrated Search

2008-03-01

This study examined multiple aspects of the Wyoming Department of Transportations Research Program. It provides numerous observations of : the overall program and the research investment portfolio as well as guidance for developing a strategic res...

Clinician scientist training program: a proposal for training medical students in clinical research.

PubMed

Mark, A L; Kelch, R P

2001-11-01

There is national alarm about a decline in the number of clinician scientists. Most of the proposed solutions have focused on housestaff and junior faculty. We propose a new national program for training medical students in clinical research. This program, coined "Clinician Scientist Training Program" (CSTP), would consist of a combined degree program in medicine (MD) and clinical research (eg, masters in translational research or masters in clinical epidemiology). Students could enroll in the program at any stage during medical school. After 3 years of medical school, students would spend at least 2 years in a combined didactic and mentored clinical research training program and then complete medical school. Students could elect to pursue more prolonged clinical research training toward a combined PhD and MD. The CSTP is designed to meet six critical challenges: 1) engage students early in clinical research training; 2) provide a didactic clinical research curriculum; 3) expose students to several years of mentored clinical research training; 4) promote debt prevention by providing tuition payments during medical education and a stipend during clinical research training; 5) facilitate prolonged exposure to a community of peers and mentors in a program with national and institutional identity and respect; and 6) permit enrollment in the program as students enter medical school or at any stage during medical school. If the success of the Medical Scientist Training Program in training medical students in basic research is a guide, the CSTP could become a linchpin for training future generations of clinician scientists.

The Role of Research in Advanced Dental Education.

ERIC Educational Resources Information Center

Profitt, William R.; Vig, Peter S.

1980-01-01

Even though research is an integral part of quality advanced dental programs, many dental departments with postdoctoral programs lack faculty and other resources for research productivity. Programs to produce clinical faculty with research training are called for through the development of clinical research centers. (JSR)

Dissemination research: the University of Wisconsin Population Health Institute.

PubMed

Remington, Patrick L; Moberg, D Paul; Booske, Bridget C; Ceraso, Marion; Friedsam, Donna; Kindig, David A

2009-08-01

Despite significant accomplishments in basic, clinical, and population health research, a wide gap persists between research discoveries (ie, what we know) and actual practice (ie, what we do). The University of Wisconsin Population Health Institute (Institute) researchers study the process and outcomes of disseminating evidence-based public health programs and policies into practice. This paper briefly describes the approach and experience of the Institute's programs in population health assessment, health policy, program evaluation, and education and training. An essential component of this dissemination research program is the active engagement of the practitioners and policymakers. Each of the Institute's programs conducts data collection, analysis, education, and dialogue with practitioners that is closely tied to the planning, implementation, and evaluation of programs and policies. Our approach involves a reciprocal exchange of knowledge with non-academic partners, such that research informs practice and practice informs research. Dissemination research serves an important role along the continuum of research and is increasingly recognized as an important way to improve population health by accelerating the translation of research into practice.

Overview of EPA Superfund human health research program.

PubMed

Kowalski, Lorelei; Denne, Jane; Dyer, Robert; Garrahan, Kevin; Wentsel, Randall S

2002-03-01

This paper presents major research needs for the Superfund program, and provides an overview of the EPA Office of Research and Development's (ORDs) current human health research program designed to fill some of those data gaps. Research is presented in terms of the risk paradigm and covers exposure, effects, and assessment activities directly funded by Superfund, as well as research not funded by Superfund but directly applicable to Superfund research needs. Research on risk management is not covered. Current research activities conducted by the Superfund program office are also included to provide a full picture of Superfund human health research activities being conducted by EPA.

View How Glaucoma May Affect Vision

MedlinePlus

... Alzheimer’s Disease Research Program Macular Degeneration Research Program National Glaucoma Research Program Molecular Neurodegeneration ... Foundation BrightFocus Foundation 22512 Gateway Center Drive Clarksburg, MD ...

Human Research Program Science Management: Overview of Research and Development Activities

NASA Technical Reports Server (NTRS)

Charles, John B.

2007-01-01

An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews

Development of a surgical educational research program-fundamental principles and challenges.

PubMed

Ahmed, Kamran; Ibrahim, Amel; Anderson, Oliver; Patel, Vanash M; Zacharakis, Emmanouil; Darzi, Ara; Paraskeva, Paraskevas; Athanasiou, Thanos

2011-05-15

Surgical educational research is the scientific investigation of any aspect of surgical learning, teaching, training, and assessment. The research into development and validation of educational tools is vital to optimize patient care. This can be accomplished by establishing high quality educational research programs within academic surgical departments. This article aims to identify the components involved in educational research and describes the challenges as well as solutions to establishing a high quality surgical educational research program. A variety of sources including journal articles, books, and online literature were reviewed in order to determine the pathways involved in conducting educational research and establishing a research program. It is vital to ensure that educational research is acceptable, innovative, robust in design, funded correctly, and disseminated successfully. Challenges faced by the current surgical research programs include structural organization, academic support, credibility, time, funding, relevance, and growth. The solutions to these challenges have been discussed. To ensure research in surgical education is of high quality and yields credible results, strong leadership in the organization of an educational research program is necessary. Copyright © 2011 Elsevier Inc. All rights reserved.

Outcomes and Research in Out-of-School Time Program Design.

ERIC Educational Resources Information Center

Peter, Nancy

Out-of-school time (OST) programs have taken on a new importance in recent years because of changes in society. This paper examines OST programming and suggests reasons and mechanisms for integrating outcomes and research into program design. It explains and promotes the integration of outcomes and research into program development, provides…

Federal High Performance Computing and Communications Program. The Department of Energy Component.

ERIC Educational Resources Information Center

Department of Energy, Washington, DC. Office of Energy Research.

This report, profusely illustrated with color photographs and other graphics, elaborates on the Department of Energy (DOE) research program in High Performance Computing and Communications (HPCC). The DOE is one of seven agency programs within the Federal Research and Development Program working on HPCC. The DOE HPCC program emphasizes research in…

25-year analysis of a dental undergraduate research training program (BSc Dent) at the University of Manitoba Faculty of Dentistry.

PubMed

Scott, J E; de Vries, J; Iacopino, A M

2008-12-01

Research in the context of the dental school has traditionally been focused on institutional/faculty accomplishments and generating new knowledge to benefit the profession. Only recently have significant efforts been made to expand the overall research programming into the formal dental curriculum, to provide students with a baseline exposure to the research and critical thinking processes, encourage evidence-based decision-making, and stimulate interest in academic/research careers. Various approaches to curriculum reform and the establishment of multiple levels of student research opportunities are now part of the educational fabric of many dental schools worldwide. Many of the preliminary reports regarding the success and vitality of these programs have used outcomes measures and metrics that emphasize cultural changes within institutions, student research productivity, and student career preferences after graduation. However, there have not been any reports from long-standing programs (a minimum of 25 years of cumulative data) that describe dental school graduates who have had the benefit of research/training experiences during their dental education. The University of Manitoba Faculty of Dentistry initiated a BSc Dent program in 1980 that awarded a formal degree for significant research experiences taking place within the laboratories of the Faculty-based researchers and has continued to develop and expand this program. The success of the program has been demonstrated by the continued and increasing demands for entry, the academic achievements of the graduates, and the numbers of graduates who have completed advanced education/training programs or returned to the Faculty as instructors. Analysis of our long-term data validates many recent hypotheses and short-term observations regarding the benefits of dental student research programs. This information may be useful in the design and implementation of dental student research programs at other dental schools.

A Collaborative Translational Autism Research Program for the Military

DTIC Science & Technology

2016-02-26

AFRL-SA-WP-TR-2016-0001 A Collaborative Translational Autism Research Program for the Military Gail E. Herman, MD, PhD; Emily...DATES COVERED (From – To) September 2012 – December 2015 4. TITLE AND SUBTITLE A Collaborative Translational Autism Research Program for the...proposed research is that a collaborative translational autism research program with the military will result in the improved diagnosis and care of those

The Department of Defense Congressionally Directed Medical Research Program: innovations in the federal funding of biomedical research.

PubMed

Young-McCaughan, Stacey; Rich, Irene M; Lindsay, Gaylord C; Bertram, Kenneth A

2002-04-01

In response to the lobbying efforts of the women's advocacy movement, in 1993 Congress authorized funds for a substantial increase in support of new and promising research aimed at the eradication of breast cancer. This appropriation resulted in a major expansion of the United States Army Medical Research and Materiel Command, Department of Defense Breast Cancer Research Program. The Office of Congressionally Directed Medical Research Programs was established within the United States Army Medical Research and Materiel Command to facilitate the management of the expanded extramural research program. Since that time, the programs have grown to include not just breast cancer but also prostate cancer, ovarian cancer, and neurofibromatosis. The unique appropriations to the Office of Congressionally Directed Medical Research Programs has resulted in a number of programmatic innovations. These include development of unique mechanisms of grant support, inclusion of consumer advocates on peer and programmatic review panels, and the introduction of criteria-based evaluation and scoring in peer review. This article describes these novel scientific management strategies and outlines their success in meeting program visions and goals.

Summer faculty fellowship program, 1984

NASA Technical Reports Server (NTRS)

Spencer, J. H. (Compiler)

1984-01-01

Since 1964, the National Aeronautics and Space Administration (NASA) has supported a program of summer faculty fellowships for engineering and science educators. In a series of collaborations between NASA research and development centers and nearby universities, engineering faculty members spend 10 or 11 weeks working with professional peers on research. The Summer Faculty Program Committee of the American Society of Engineering Education supervises the programs. Objectives: (1) to further the professional knowledge of a qualified between participants and NASA; (3) to enrich and refresh the research and teaching activities of participants institutions; and (4) to contribute to the research objectives of the NASA center. Program Description: College or university faculty members will be appointed as research fellows to spend 10 weeks in cooperative research and study at the NASA-Langley Research Center. The fellow will devote approximately 90 percent of the time to a research problem and the remaining time to a study program. The study program will consist of lectures and seminars on topics of general interest or that are directly relevant to the fellow's research project. The lecturers and seminar leaders will be distinguished scientists and engineers from NASA, education, or industry.

NASA/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program 1987

NASA Technical Reports Server (NTRS)

Tiwari, Surendra N. (Compiler)

1987-01-01

Since 1964, NASA has supported a program of summer faculty fellowships for engineering and science educators. In a series of collaborations between NASA research and development centers and nearby universities, engineering faculty members spend 10 or 11 weeks working with professional peers on research. The Summer Faculty Program Committee of the American Society for Engineering Education supervises the programs. Objectives: (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate and exchange ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of participants' institutions; (4) to contribute to the research objectives of the NASA center. Program Description: College or university faculty members were appointed as Research Fellows to spend 10 weeks in cooperative research and study at the NASA Langley Research Center. The Fellow devoted approximately 90 percent of the time to a research problem and the remaining time to a study program. The study program consisted of lectures and seminars on topics of interest or that are directly relevant to the Fellows' research topic.

The Future of Nearshore Processes Research: U.S. Integrated Coastal Research Program

NASA Astrophysics Data System (ADS)

Elko, N.; Feddersen, F.; Foster, D. L.; Hapke, C. J.; Holman, R. A.; McNinch, J.; Mulligan, R. P.; Ozkan-Haller, H. T.; Plant, N. G.; Raubenheimer, B.

2016-02-01

The authors, representing the acting Nearshore Advisory Council, have developed an implementation plan for a U.S. Nearshore Research Program based on the 2015 Future of Nearshore Processes report that was authored by the nearshore community. The objectives of the plan are to link research programs across federal agencies, NGOs, industry, and academia into an integrated national program and to increase academic and NGO participation in federal agency nearshore processes research. A primary recommendation is interagency collaboration to build a research program that will coordinate and fund U.S. nearshore processes research across three broad research themes: 1) long-term coastal evolution due to natural and anthropogenic processes; 2) extreme events; and 3) physical, biological and chemical processes impacting human and ecosystem health. The plan calls for a new program to be developed by an executive committee of federal agency leaders, NGOs, and an academic representative, created similarly to the existing NOPP program. This leadership will be established prior to the 2016 Ocean Sciences meeting and will have agreed on responsibilities and a schedule for development of the research program. To begin to understand the scope of today's U.S. coastal research investment, a survey was distributed to ten federal agency R&D program heads. Six of the ten agencies indicated that they fund coastal research, with a combined annual coastal research budget of nearly 100 million (NSF has not responded). The priority of the three research themes were ranked nearly equally and potential research support ranged from 15-19 million for each theme, with approximately 12 million as direct contribution to academic research. Beyond addressing our fundamental science questions, it is critical that the nearshore community stay organized to represent academic interests on the new executive committee. The program goal is the integration of academic, NGO, and federal agencies.

Urologic Oncology Branch - Training - NCI/AFUD | Center for Cancer Research

Cancer.gov

Postdoctoral Research Training Program This program is designed to train Ph.D. postdoctoral scientists in the growing field of urologic oncology. This program offers fellows the opportunity to participate in a diverse training experience that includes clinical and laboratory research on several urologic malignancies. The program provides an opportunity for selected individuals to complete a research project under the direction of a Senior Investigator in the Intramural Program of the National Cancer Institute.

Summer Research Program (1992). Summer Faculty Research Program (SFRP) Reports. Volume 3. Phillips Laboratory.

DTIC Science & Technology

1992-12-28

Phillips Laboratory Kirtland Air Force Base NM 87117-6008 Sponsored by: Air Force Office of Scientific Research Bolling Air Force Base...Zindel, D.: 1963, Z. Astrophys. 57, 82. 29-13 FINAL REPORT SUMMER FACULTY RESEARCH PROGRAM AT PHILLIPS LABORATORY KIRTLAND AIR FORCE BASE...Program Phillips Laboratory Sponsored by: Air Force Office of Scientific

Reading Programs for Students in the Lower Elementary Grades: What Does the Research Say?

ERIC Educational Resources Information Center

Briggs, Kerri L.; Clark, Catherine

This report aims to disseminate research findings about reading programs for early elementary grades in a summary format useful for educators. The report features programs with clear descriptions and useful research, programs for non-English speaking children and research on basal reader series were not included. The four sections of the report…

WisDOT research program : 2014 annual report.

DOT National Transportation Integrated Search

2015-01-01

WisDOT managed a $4.2 million program for research, library and technology transfer services : during federal fiscal year 2014. Ninety percent ($3.76 million) of the program is funded by the state : planning and research part 2 (SPR2) federal program...

WisDOT research program : 2013 annual report.

DOT National Transportation Integrated Search

2013-01-01

WisDOT managed a $4.2 million program for research, library : and technology transfer services during federal fiscal year 2013. : Ninety percent ($3.76 million) of the program is funded by the State Planning and Research Part 2 (SPR2) federal program...

ORD Water Quality Research Program Mid-Cycle Review - June 2009

EPA Pesticide Factsheets

The Board of Scientific Counselors (BOSC) completed a mid-cycle review of the Office of Research and Development’s (ORD) Water Quality Research Program (WQRP), focusing on Agency efforts to enhance the program following the 2006 BOSC program review.

7 CFR 1207.311 - Programs and projects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan Definitions § 1207.311 Programs and projects. Programs and projects mean those research, development, advertising or promotion programs or projects developed by the...

Programs for developing the pipeline of early-career geriatric mental health researchers: outcomes and implications for other fields.

PubMed

Bartels, Stephen J; Lebowitz, Barry D; Reynolds, Charles F; Bruce, Martha L; Halpain, Maureen; Faison, Warachal E; Kirwin, Paul D

2010-01-01

This report summarizes the findings and recommendations of an expert consensus workgroup that addressed the endangered pipeline of geriatric mental health (GMH) researchers. The workgroup was convened at the Summit on Challenges in Recruitment, Retention, and Career Development in Geriatric Mental Health Research in late 2007. Major identified challenges included attracting and developing early-career investigators into the field of GMH research; a shortfall of geriatric clinical providers and researchers; a disproportionate lack of minority researchers; inadequate mentoring and career development resources; and the loss of promising researchers during the vulnerable period of transition from research training to independent research funding. The field of GMH research has been at the forefront of developing successful programs that address these issues while spanning the spectrum of research career development. These programs serve as a model for other fields and disciplines. Core elements of these multicomponent programs include summer internships to foster early interest in GMH research (Summer Training on Aging Research Topics-Mental Health Program), research sponsorships aimed at recruitment into the field of geriatric psychiatry (Stepping Stones), research training institutes for early career development (Summer Research Institute in Geriatric Psychiatry), mentored intensive programs on developing and obtaining a first research grant (Advanced Research Institute in Geriatric Psychiatry), targeted development of minority researchers (Institute for Research Minority Training on Mental Health and Aging), and a Web-based clearinghouse of mentoring seminars and resources (MedEdMentoring.org). This report discusses implications of and principles for disseminating these programs, including examples of replications in fields besides GMH research.

Glenn Research Center Human Research Program: Overview

NASA Technical Reports Server (NTRS)

Nall, Marsha M.; Myers, Jerry G.

2013-01-01

The NASA-Glenn Research Centers Human Research Program office supports a wide range of technology development efforts aimed at enabling extended human presence in space. This presentation provides a brief overview of the historical successes, current 2013 activities and future projects of NASA-GRCs Human Research Program.

Gas Research Institute research program summary: Goals and accomplishments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-07-01

Gas Research Institute's research and development programs pursue technologies that maximize the value of gas energy services while minimizing the cost of supplying and delivering gaseous fuels. Four program areas, Supply Options, End Use, Gas Operations, and Crosscutting Research, are described in the report, together with related project titles and numbers. Also included are summaries of 1990 research results, research collaboration and supported work, and patents and licensing agreements. Glossaries of budget and program terms and of acronyms and abbreviations often used in the GRI literature are added.

Agricultural Research Service: biodefense research.

PubMed

Gay, C G

2013-01-01

The National Animal Health Program at the Agricultural Research Service (ARS), United States Department of Agriculture (USDA), includes research programs dedicated to the defense of animal agriculture against the treat of biological agents with the potential of significant economic harm and/or public health consequences. This article provides a summary of the program and identifies its relevance to national initiatives to protect livestock and poultry as well as global food security. An introduction to setting research priorities and a selection of research accomplishments that define the scope of the biodefense research program is provided.

Increasing chronic disease research capacity in Guatemala through a mentoring program.

PubMed

Barnoya, Joaquin; Monzon, Jose C; Colditz, Graham A

2013-09-12

The Chronic Disease Research Fellowship Program (RFP) aims to build the research capacity of recent medical graduates to support the development of chronic disease control strategies. Guatemala is undergoing an epidemiologic transition. However, given the way universities and the health care system are structured, it lacks an environment that fosters research careers and generates the required knowledge to implement sound public health policies and clinical strategies. The RFP was implemented at the Cardiovascular Unit of Guatemala. This 4-year Program recruited two one-year fellows and provided funding to define a research topic, write a protocol and implement the research. Strong emphasis is placed on developing skills in knowledge translation and exchange to bridge the "know-do" gap. Close mentoring relationships between the Principal Investigator and former and current fellows are fostered through the Program. The mentoring Program has generated strategic data to support the implementation of sound chronic disease control strategies, mainly related to tobacco control. Results have been presented nationally and internationally. Research training has included principles of biostatistics and epidemiology, and a journal club. The Program is increasingly generating interest among medical graduates to pursue further research training abroad and is building local research capacity. Fellows and research assistants have created a research network in Guatemala and abroad. The main obstacle the Program faces is ensuring long-term sustainability. A mentoring program can lead to an increase in research interest and capacity in a low-income country with little research infrastructure.

National Geospatial-Intelligence Agency Academic Research Program

NASA Astrophysics Data System (ADS)

Loomer, S. A.

2004-12-01

"Know the Earth.Show the Way." In fulfillment of its vision, the National Geospatial-Intelligence Agency (NGA) provides geospatial intelligence in all its forms and from whatever source-imagery, imagery intelligence, and geospatial data and information-to ensure the knowledge foundation for planning, decision, and action. To achieve this, NGA conducts a multi-disciplinary program of basic research in geospatial intelligence topics through grants and fellowships to the leading investigators, research universities, and colleges of the nation. This research provides the fundamental science support to NGA's applied and advanced research programs. The major components of the NGA Academic Research Program (NARP) are: - NGA University Research Initiatives (NURI): Three-year basic research grants awarded competitively to the best investigators across the US academic community. Topics are selected to provide the scientific basis for advanced and applied research in NGA core disciplines. - Historically Black College and University - Minority Institution Research Initiatives (HBCU-MI): Two-year basic research grants awarded competitively to the best investigators at Historically Black Colleges and Universities, and Minority Institutions across the US academic community. - Director of Central Intelligence Post-Doctoral Research Fellowships: Fellowships providing access to advanced research in science and technology applicable to the intelligence community's mission. The program provides a pool of researchers to support future intelligence community needs and develops long-term relationships with researchers as they move into career positions. This paper provides information about the NGA Academic Research Program, the projects it supports and how other researchers and institutions can apply for grants under the program.

7 CFR 3403.4 - Three-phase program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Program Description § 3403.4 Three-phase program. The Small Business Innovation Research Grants Program is carried out in three separate phases...

7 CFR 3403.4 - Three-phase program.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Program Description § 3403.4 Three-phase program. The Small Business Innovation Research Grants Program is carried out in three separate phases...

7 CFR 3403.4 - Three-phase program.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Program Description § 3403.4 Three-phase program. The Small Business Innovation Research Grants Program is carried out in three separate phases...

1999 Research Reports: NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Hosler, E. Ramon (Editor); Buckingham, Gregg (Editor)

2000-01-01

This document is a collection of technical reports on research conducted by the participants in the 1999 NASA/ASEE Summer Faculty Fellowship Program at the Kennedy Space Center (KSC). This was the 15th year that a NASA/ASEE program has been conducted at KSC. The 1999 program was administered by the University of Central Florida in cooperation with KSC. The program was operated under the auspices of the American Society for Engineering Education (ASEE and the Education Division, NASA Headquarters, Washington, DC, and KSC. The KSC Program was one of nine such Aeronautics and Space Research Programs funded by NASA Headquarters in 1999. The NASA/ASEE Program is intended to be a two-year program to allow in-depth research by the university faculty member.

A potential role of anti-poverty programs in health promotion

PubMed Central

Silverman, Kenneth; Holtyn, August F.; Jarvis, Brantley

2016-01-01

Poverty is one of the most pervasive risk factors underlying poor health, but is rarely targeted to improve health. Research on the effects of anti-poverty interventions on health has been limited, at least in part because funding for that research has been limited. Anti-poverty programs have been applied on a large scale, frequently by governments, but without systematic development and cumulative programmatic experimental studies. Anti-poverty programs that produce lasting effects on poverty have not been developed. Before evaluating the effect of anti-poverty programs on health, programs must be developed that can reduce poverty consistently. Anti-poverty programs require systematic development and cumulative programmatic scientific evaluation. Research on the therapeutic workplace could provide a model for that research and an adaptation of the therapeutic workplace could serve as a foundation of a comprehensive anti-poverty program. Once effective anti-poverty programs are developed, future research could determine if those programs improve health in addition to increasing income. The potential personal, health and economic benefits of effective anti-poverty programs could be substantial, and could justify the major efforts and expenses that would be required to support systematic research to develop such programs. PMID:27235603

A potential role of anti-poverty programs in health promotion.

PubMed

Silverman, Kenneth; Holtyn, August F; Jarvis, Brantley P

2016-11-01

Poverty is one of the most pervasive risk factors underlying poor health, but is rarely targeted to improve health. Research on the effects of anti-poverty interventions on health has been limited, at least in part because funding for that research has been limited. Anti-poverty programs have been applied on a large scale, frequently by governments, but without systematic development and cumulative programmatic experimental studies. Anti-poverty programs that produce lasting effects on poverty have not been developed. Before evaluating the effect of anti-poverty programs on health, programs must be developed that can reduce poverty consistently. Anti-poverty programs require systematic development and cumulative programmatic scientific evaluation. Research on the therapeutic workplace could provide a model for that research and an adaptation of the therapeutic workplace could serve as a foundation of a comprehensive anti-poverty program. Once effective anti-poverty programs are developed, future research could determine if those programs improve health in addition to increasing income. The potential personal, health and economic benefits of effective anti-poverty programs could be substantial, and could justify the major efforts and expenses that would be required to support systematic research to develop such programs. Copyright © 2016 Elsevier Inc. All rights reserved.

How does investment in research training affect the development of research networks and collaborations?

PubMed

Paina, Ligia; Ssengooba, Freddie; Waswa, Douglas; M'imunya, James M; Bennett, Sara

2013-05-20

Whether and how research training programs contribute to research network development is underexplored. The Fogarty International Center (FIC) has supported overseas research training programs for over two decades. FIC programs could provide an entry point in the development of research networks and collaborations. We examine whether FIC's investment in research training contributed to the development of networks and collaborations in two countries with longstanding FIC investments - Uganda and Kenya - and the factors which facilitated this process. As part of two case studies at Uganda's Makerere University and Kenya's University of Nairobi, we conducted 53 semi-structured in-depth interviews and nine focus group discussions. To expand on our case study findings, we conducted a focused bibliometric analysis on two purposively selected topic areas to examine scientific productivity and used online network illustration tools to examine the resulting network structures. FIC support made important contributions to network development. Respondents from both Uganda and Kenya confirmed that FIC programs consistently provided trainees with networking skills and exposure to research collaborations, primarily within the institutions implementing FIC programs. In both countries, networks struggled with inclusiveness, particularly in HIV/AIDS research. Ugandan respondents perceived their networks to be more cohesive than Kenyan respondents did. Network cohesiveness was positively correlated with the magnitude and longevity of FIC's programs. Support from FIC grants to local and regional research network development and networking opportunities, such as conferences, was rare. Synergies between FIC programs and research grants helped to solidify and maintain research collaborations. Networks developed where FIC's programs focused on a particular institution, there was a critical mass of trainees with similar interests, and investments for network development were available from early implementation. Networks were less likely to emerge where FIC efforts were thinly scattered across multiple institutions. The availability of complementary research grants created opportunities for researchers to collaborate in grant writing, research implementation, and publications. FIC experiences in Uganda and Kenya showcase the important role of research training programs in creating and sustaining research networks. FIC programs should consider including support to research networks more systematically in their capacity development agenda.

Global Scale Atmospheric Processes Research Program Review

NASA Technical Reports Server (NTRS)

Worley, B. A. (Editor); Peslen, C. A. (Editor)

1984-01-01

Global modeling; satellite data assimilation and initialization; simulation of future observing systems; model and observed energetics; dynamics of planetary waves; First Global Atmospheric Research Program Global Experiment (FGGE) diagnosis studies; and National Research Council Research Associateship Program are discussed.

23 CFR 420.201 - What is the purpose of this subpart?

Code of Federal Regulations, 2010 CFR

2010-04-01

....201 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING AND RESEARCH PROGRAM ADMINISTRATION Research, Development and Technology Transfer Program... requirements for research, development, and technology transfer (RD&T) activities, programs, and studies...

Medical Research Volunteer Program (MRVP): innovative program promoting undergraduate research in the medical field.

PubMed

Dagher, Michael M; Atieh, Jessica A; Soubra, Marwa K; Khoury, Samia J; Tamim, Hani; Kaafarani, Bilal R

2016-06-06

Most educational institutions lack a structured system that provides undergraduate students with research exposure in the medical field. The objective of this paper is to describe the structure of the Medical Research Volunteer Program (MRVP) which was established at the American University of Beirut, Lebanon, as well as to assess the success of the program. The MRVP is a program that targets undergraduate students interested in becoming involved in the medical research field early on in their academic career. It provides students with an active experience and the opportunity to learn from and support physicians, clinical researchers, basic science researchers and other health professionals. Through this program, students are assigned to researchers and become part of a research team where they observe and aid on a volunteer basis. This paper presents the MRVP's four major pillars: the students, the faculty members, the MRVP committee, and the online portal. Moreover, details of the MRVP process are provided. The success of the program was assessed by carrying out analyses using information gathered from the MRVP participants (both students and faculty). Satisfaction with the program was assessed using a set of questions rated on a Likert scale, ranging from 1 (lowest satisfaction) to 5 (highest satisfaction). A total of 211 students applied to the program with a total of 164 matches being completed. Since the beginning of the program, three students have each co-authored a publication in peer-reviewed journals with their respective faculty members. The majority of the students rated the program positively. Of the total number of students who completed the program period, 35.1 % rated the effectiveness of the program with a 5, 54.8 % rated 4, and 8.6 % rated 3. A small number of students gave lower ratings of 2 and 1 (1.1 % and 0.4 %, respectively). The MRVP is a program that provides undergraduate students with the opportunity to learn about research firsthand as they volunteer and aid in different research projects. This program also provides faculty members with the help to conduct their research projects and opportunity to influence future generations. It was shown that so far the MRVP has been successful in reaching its goals, for both students and faculty.

Mentoring advanced practice nurses in research: recommendations from a pilot program.

PubMed

Leung, Doris; Widger, Kimberley; Howell, Doris; Nelson, Sioban; Molassiotis, Alex

2012-01-01

Advanced Practice Nurses (APNs) need research skills to develop and advance their practice and, yet, many have limited access to research training and support following completion of their advanced degree. In this paper we report on the development, delivery, and evaluation of an innovative pilot program that combined research training and one-to-one mentorship for nine APNs in conducting research relevant to their practice. The program was organized within an academic institution and its affiliated hospitals in Toronto, Canada. Our experience with this program may assist those in other organizations to plan and deliver a similar program for APN research mentorship.

QUARTERLY TECHNICAL PROGRESS REPORT, JULY, AUGUST, SEPTEMBER 1966.

DTIC Science & Technology

Contents: Circuit research program; Hardware systems research; Software systems research program; Numerical methods, computer arithmetic and...artificial languages; Library automation; Illiac II service , use, and program development; IBM service , use, and program development; Problem specifications; Switching theory and logical design; General laboratory information.

Evolution of a Teacher Professional Development Program that Promotes Teacher and Student Research

NASA Astrophysics Data System (ADS)

Pompea, S. M.; Croft, S. K.; Garmany, C. D.; Walker, C. E.

2005-12-01

The Research Based Science Education (RBSE) and Teacher Leaders in Research Based Science (TLRBSE) programs at the National Optical Astronomy Observatory have been evolving for nearly ten years. Our current program is actually a team of programs aiding teachers in doing research with small telescopes, large research-grade telescopes, astronomical data archives, and the Spitzer Space Telescope. Along the way, as these programs evolved, a number of basic questions were continuously discussed by the very talented program team. These questions included: 1) What is real research and why should we encourage it? 2) How can it be successfully brought to the classroom? 3) What is the relative importance of teacher content knowledge versus science process knowledge? 4) How frustrating should an authentic research experience be? 5) How do we measure the success of our professional development program? 6) How should be evaluate and publish student work? 7) How can teachers work together on a team to pursue research? 8) What is the model for interaction of teachers and researchers - equal partners versus the graduate student/apprentice model? 9) What is the ideal mix of skills for a professional development team at NOAO? 10) What role can distance learning play in professional preparation? 11) What tools are needed for data analysis? 12) How can we stay funded? Our evolving program has also been used as a test bed to examine new models of teacher's professional development that may aid our outreach efforts in the Large Synoptic Survey Telescope program, the Thirty-Meter Telescope program, and the National Virtual Observatory program. We will describe a variety of lessons learned (and relearned) and try to describe best practices in promoting teacher and student research. The TLRBSE Program is funded by the National Science Foundation under ESI 0101982, funded through the AURA/NSF Cooperative Agreement AST-9613615. NOAO is operated by the Association of Universities for Research in Astronomy (AURA), Inc. under cooperative agreement with the National Science Foundation.

Institute for Scientific and Educational Technology (ISET)-Education, Research and Training Programs in Engineering and Sciences

NASA Technical Reports Server (NTRS)

Tiwari, S. N. (Principal Investigator); Massenberg, Samuel E. (Technical Monitor)

2002-01-01

The 'Institute for Scientific and Educational Technology' has been established to provide a mechanism through which universities and other research organizations may cooperate with one another and with different government agencies and industrial organizations to further and promote research, education, and training programs in science, engineering, and related fields. This effort has been undertaken consistent with the national vision to 'promote excellence in America s educational system through enhancing and expanding scientific and technological competence.' The specific programs are directed in promoting and achieving excellence for individuals at all levels (elementary and secondary schools, undergraduate and graduate education, and postdoctoral and faculty research). The program is consistent with the existing activities of the Institute for Computational and Applied Mechanics (ICAM) and the American Society for Engineering Education (ASEE) at NASA Langley Research Center (LaRC). The efforts will be directed to embark on other research, education, and training activities in various fields of engineering, scientific, and educational technologies. The specific objectives of the present program may be outlined briefly as follows: 1) Cooperate in the various research, education, and technology programs of the Office of Education at LaRC. 2) Develop procedures for interactions between precollege, college, and graduate students, and between faculty and students at all levels. 3) Direct efforts to increase the participation by women and minorities in educational programs at all levels. 4) Enhance existing activities of ICAM and ASEE in education, research, and training of graduate students and faculty. 5) Invite distinguished scholars as appropriate and consistent with ISET goals to spend their summers and/or sabbaticals at NASA Langley andor ODU and interact with different researchers and graduate students. Perform research and administrative activities as needed to carry out the above mentioned activities. 6) The implementation of various activities of the ISET programs is carried out through cooperative efforts between Old Dominion University (ODU) and the Office of Education at LaRC. At present, major efforts are directed on the following ISET Programs: ICAM Programs, Academic Programs, Educational Research, Outreach Programs, Educational Technology and Cooperative Programs. These programs are described in the following sections.

Guidelines for the Evaluation of Bilingual Education Programs.

ERIC Educational Resources Information Center

Cardoza, Desdemona

Principles of program evaluation research are outlined so that bilingual education program coordinators can conduct methodologically acceptable program evaluations. The three basic principles of evaluation research are: identification of the program participants, definition of the program intervention, and assessment of program effectiveness.…

Overview of NASA's Pulsed Plasma Thruster Development Program

NASA Technical Reports Server (NTRS)

Pencil, Eric J.; Kamhawi, Hani; Arrington, Lynn A.

2004-01-01

NASA's Pulsed Plasma Thruster Program consists of flight demonstration experiments, base research, and development efforts being conducted through a combination of in-house work, contracts, and collaborative programs. The program receives sponsorship from Energetics Project, the New Millennium Program, and the Small Business Innovative Research Program. The Energetics Project sponsors basic and fundamental research to increase thruster life, improve thruster performance, and reduce system mass. The New Millennium Program sponsors the in-orbit operation of the Pulsed Plasma Thruster experiment on the Earth Observing 1 spacecraft. The Small Business Innovative Research Program sponsors the development of innovative diamond-film capacitors, piezoelectric ignitors, and advanced fuels. Programmatic background, recent technical accomplishments, and future activities for each programmatic element are provided.

Lessons Learned: The Evolution of an Undergraduate Research Program

ERIC Educational Resources Information Center

Smith, Gregory; Laker, Lauren; Tesch, Debbie

2013-01-01

Undergraduate research programs are commonplace at many universities. However, little research has been conducted to evaluate their ongoing and long-term effectiveness from the standpoint of the undergraduate student researcher. In an effort to gain perspective from the student researcher, including their thoughts on such a program, a survey was…

Broadening measures of success: results of a behavioral health translational research training program.

PubMed

Baldwin, Julie A; Williamson, Heather J; Eaves, Emery R; Levin, Bruce L; Burton, Donna L; Massey, Oliver T

2017-07-24

While some research training programs have considered the importance of mentoring in inspiring professionals to engage in translational research, most evaluations emphasize outcomes specific to academic productivity as primary measures of training program success. The impact of such training or mentoring programs on stakeholders and local community organizations engaged in translational research efforts has received little attention. The purpose of this evaluation is to explore outcomes other than traditional academic productivity in a translational research graduate certificate program designed to pair graduate students and behavioral health professionals in collaborative service-learning projects. Semi-structured qualitative interviews with scholars, community mentors, and academic mentors were conducted regarding a translational research program to identify programmatic impacts. Interviews were transcribed and coded by the research team to identify salient themes related to programmatic outcomes. Results are framed using the Translational Research Impact Scale which is organized into three overarching domains of potential impact: (1) research-related impacts, (2) translational impacts, and (3) societal impacts. This evaluation demonstrates the program's impact in all three domains of the TRIS evaluation framework. Graduate certificate participants (scholars) reported that gaining experience in applied behavioral health settings added useful skills and expertise to their present careers and increased their interest in pursuing translational research. Scholars also described benefits resulting from networks gained through participation in the program, including valuable ties between the university and community behavioral health organizations. This evaluation of the outcomes of a graduate certificate program providing training in translational research highlights the need for more community-oriented and practice-based measures of success. Encouraging practitioner involvement in translational research is vital to translate knowledge into practice and to enable practice-based needs to inform research and policy. A more flexible approach to measuring programmatic success in research training programs can help bridge the knowledge translation gap.

Human Research Program Requirements Document. Human Research Program Revision E

NASA Technical Reports Server (NTRS)

Vargas, Paul

2011-01-01

This document defines, documents, and allocates the Human Research Program (HRP) requirements to the HRP Program Elements. It also establishes the flow of requirements from the Human Exploration and Operations Mission Directorate (HEOMD) and the Office of the Chief Health and Medical Officer (OCHMO) down to the various HRP Program Elements to ensure that human research and technology countermeasure investments support the delivery of countermeasures and technologies that satisfy HEOMD's and OCHMO's exploration mission requirements.

Lewis' Educational and Research Collaborative Internship Program

NASA Technical Reports Server (NTRS)

Heyward, Ann; Gott, Susan (Technical Monitor)

2004-01-01

The Lewis Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships in addition to summer and winter extensions if funding is available and/or is requested by mentor (no less than 1 week no more than 4 weeks) for undergraduate/graduate students and secondary school teachers. Students who meet the travel reimbursement criteria receive up to $500 for travel expenses. Approximately 178 interns are selected to participate in this program each year and begin arriving the fourth week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, and lectures. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds. The purpose of this report is to document the program accomplishments for 2004.

The New Mexico EPSCoR Undergraduate Research Opportunities Program: A Successful Summer Research Program for Community College and PUI College Students

NASA Astrophysics Data System (ADS)

Pullin, M. J.

2013-12-01

The statewide NSF New Mexico EPSCoR Program (Climate Change and Water in New Mexico) sponsored a summer undergraduate research program from 2009 to 2013. This program was open to undergraduates attending the state's community colleges and primarily undergraduate institutions (PUIs). Participants who are chosen for the program attend a week of workshops on climate change, hydrology, water quality and professional development. Following that, they spend eight weeks working with an EPSCoR-funded scientist at a research intensive university or related field site. Participants are paired during their research project. This strategy has been shown to be a key factor in the success and comfort level of the participants. The program concludes with a research conference and many of the participants later present their work at national and regional conferences. The program has shown to be effective at introducing students from non-research institutions to authentic research in the Earth and Environmental Sciences and improving their confidence in future success at higher degree levels. The program is also successful at recruiting underrepresented minority students, mainly from Hispanic and Native American populations. We will also present data on participant degree completions, transfers to four year colleges, STEM career attainment, and graduate school admissions.

Research-Practice Linkages in Extension Leadership Development Programs: Focus on Community Leadership Development Programs. A Report.

ERIC Educational Resources Information Center

Vandenberg, Lela; And Others

The Research-Practice Linkages Project sought to identify the knowledge base supporting community leadership development (CLD) programs of the Cooperative Extension Service and to determine linkages between Extension programs and CLD research. A mail questionnaire was completed by 492 Extension staff involved in CLD programs in 18 states and 42…

Advancing Research in the National Science Foundation's Advanced Technological Education Program

ERIC Educational Resources Information Center

Wingate, Lori A.

2017-01-01

Advanced Technological Education is distinct from typical National Science Foundation programs in that it is essentially a training--not research--program, and most grantees are located at technical and two-year colleges. This article presents empirical data on the status of research in the program, discusses the program's role in supporting NSF's…

78 FR 55084 - Proposed Collection; 60-day Comment Request; Data Collection To Understand How NIH Programs Apply...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-09

..., network leadership, program administrators, and research site staff. Survey 2500 1 30/60 1250 Interview... Research Programs (MIRP) SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A) of the... to Understand How NIH Programs Apply Methodologies to Improve Their Research Programs (MIRP), 0925New...

Environmental Sciences Division annual progress report for period ending September 30, 1981

DOE Office of Scientific and Technical Information (OSTI.GOV)

Auerbach, S.I.; Reichle, D.E.

1982-04-01

Research programs from the following sections and programs are summarized: aquatic ecology, environmental resources, earth sciences, terrestrial ecology, advanced fossil energy program, toxic substances program, environmental impacts program, biomass, low-level waste research and development program, US DOE low-level waste management program, and waste isolation program.

STC Synthesis of Best Practices for Determining Value of Research Results : Research Project Capsule

DOT National Transportation Integrated Search

2012-09-01

The RAC Region II has initiated a collaborative research program consortium : through the Transportation Pooled Fund (TPF) Program. The research program : is called the Southeast Transportation Consortium (STC) and is intended to : encourage coordina...

STC synthesis of research results for water quality management at construction sites : research project capsule.

DOT National Transportation Integrated Search

2012-07-01

The RAC Region II has initiated a collaborative research program consortium through the : Transportation Pooled Fund (TPF) Program. The research program is called the Southeast : Transportation Consortium (STC) and is intended to encourage coordinati...

Evaluating department of transportation's research program : a methodology and case study.

DOT National Transportation Integrated Search

2012-06-01

An effective research program within a transportation organization can be a valuable asset to accomplish the goals of the overall : mission. Determining whether a research program is pursuing relevant research projects and obtaining results for the s...

7 CFR 1206.50 - Programs, plans, and projects.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions Promotion, Research, and Information § 1206.50 Programs, plans, and projects. (a) The Board shall receive and evaluate... establishment, issuance, effectuation, and administration of appropriate programs for promotion, research, and...

7 CFR 1221.121 - Programs, plans, and projects.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Promotion, Research, and Information § 1221.121 Programs, plans, and projects. (a) The Board shall receive and... establishment, issuance, effectuation, and administration of appropriate programs for promotion, research, and...

7 CFR 1206.50 - Programs, plans, and projects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions Promotion... establishment, issuance, effectuation, and administration of appropriate programs for promotion, research, and... the Board to ensure that it contributes to an effective program of promotion, research, or information...

Developing a Research Program Using Qualitative and Quantitative Approaches.

ERIC Educational Resources Information Center

Beck, Cheryl Tatano

1997-01-01

A research program on postpartum depression is used to illustrate the use of both qualitative and quantitative approaches. The direction of a research program is thus not limited by the type of methods in which a researcher has expertise. (SK)

Aeronautics Research and Technology Program and specific objectives, fiscal year 1982

NASA Technical Reports Server (NTRS)

Olstad, W. B.

1981-01-01

The Aeronautics Research and Technology program is broken down into two program areas (research and technology base, and systems technology programs) which are further broken down into succeedingly more detailed activities to form a work breakdown structure for the aeronautics program: program area, program/discipline objective, specific objective, and research and technology objective and plan (RTOP). A detailed view of this work breakdown structure down to the specific objective level is provided, and goals or objectives at each of these levels are set forth. What is to be accomplished and why are addressed, but not how. The letter falls within the domain of the RTOP.

Program of Research in Flight Dynamics in The George Washington University at NASA Langley Research Center, Hampton, Virginia

NASA Technical Reports Server (NTRS)

Klein, Vladislav

2002-01-01

The program objectives were defined in the original proposal entitled 'Program of Research in Flight Dynamics in the JIAFS at NASA Langley Research Center' which was originated March 20, 1975, and yearly renewals of the research program dated December 1, 1998 to December 31, 2002. The program included three major topics: 1) Improvement of existing methods and development of new methods for flight and wind tunnel data analysis based on system identification methodology; 2) Application of these methods to flight and wind tunnel data obtained from advanced aircraft; 3) Modeling and control of aircraft. The principal investigator of the program was Dr. Vladislav Klein, Professor Emeritus at The George Washington University, DC. Seven Graduate Research Scholar Assistants (GRSA) participated in the program. The results of the research conducted during four years of the total co-operative period were published in 2 NASA Technical Reports, 3 thesis and 3 papers. The list of these publications is included.

1997 NASA-ODU American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Tiwari, Surendra N. (Compiler); Young, Deborah B. (Compiler)

1998-01-01

Since 1964, the National Aeronautics and Space Administration (NASA) has supported a program of summer faculty fellowships for engineering and science educators. In a series of collaborations between NASA research and development centers and nearby universities, engineering faculty members spend 10 weeks working with professional peers on research. The Summer Faculty Program Committee of the American Society for Engineering Education supervises the programs. Objectives of the program are as follows: (1) To further the professional knowledge of qualified engineering and science faculty members, (2) To stimulate and exchange ideas between participants and NASA; (3) To enrich and refresh the research and teaching activities of participants' institutions; and (4) To contribute to the research objectives of the NASA center. Program description is as follows: College or university faculty members will be appointed as Research Fellows to spend 10 weeks in cooperative research and study at the NASA Langley Research Center. The Fellow will devote approximately 90 percent of the time to a research problem and the remaining time to a study program. The study program will consist of lectures and seminars on topics of interest or that are directly relevant to the Fellows' research topics. The lectures and seminar leaders will be distinguished scientists and engineers from NASA, education, and industry.

Developing a Successful High School Science Research Program via Teacher Training, Student Internships, and Community Support

NASA Astrophysics Data System (ADS)

Danch, J. M.; Darytichen, F.

2004-12-01

The purpose of the Science Research Program is to allow students to perform authentic scientific research in disciplines of their choosing over a period of 3 years. The success of the program has allowed for expansion including community involvement, student mentorship, and a series of professional development programs. Through state and national competition and community symposia, student research is evaluated, showcased, and subsequently supported both idealistically and financially by local government and industrial partnerships. Student internships and university/industrial mentorship programs allow students to pursue research topics and utilize equipment exceeding the scope of the secondary science classroom. Involved teachers have developed and delivered professional development workshops to foster the successful implementation of scientific research programs at additional high schools throughout the state.

NASA's Microgravity Research Program

NASA Technical Reports Server (NTRS)

Woodard, Dan

1998-01-01

This fiscal year (FY) 1997 annual report describes key elements of the NASA Microgravity Research Program (MRP) as conducted by the Microgravity Research Division (MRD) within NASA's Office of Life and Microgravity, Sciences and Applications. The program's goals, approach taken to achieve those goals, and program resources are summarized. All snapshots of the program's status at the end of FY 1997 and a review of highlights and progress in grounds and flights based research are provided. Also described are major space missions that flew during FY 1997, plans for utilization of the research potential of the International Space Station, the Advanced Technology Development (ATD) Program, and various educational/outreach activities. The MRP supports investigators from academia, industry, and government research communities needing a space environment to study phenomena directly or indirectly affected by gravity.

Selective Separation of Trivalent Actinides from Lanthanides by Aqueous Processing with Introduction of Soft Donor Atoms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kenneth L. Nash

2009-09-22

Implementation of a closed loop nuclear fuel cycle requires the utilization of Pu-containing MOX fuels with the important side effect of increased production of the transplutonium actinides, most importantly isotopes of Am and Cm. Because the presence of these isotopes significantly impacts the long-term radiotoxicity of high level waste, it is important that effective methods for their isolation and/or transmutation be developed. Furthermore, since transmutation is most efficiently done in the absence of lanthanide fission products (high yield species with large thermal neutron absorption cross sections) it is important to have efficient procedures for the mutual separation of Am andmore » Cm from the lanthanides. The chemistries of these elements are nearly identical, differing only in the slightly stronger strength of interaction of trivalent actinides with ligand donor atoms softer than O (N, Cl-, S). Research being conducted around the world has led to the development of new reagents and processes with considerable potential for this task. However, pilot scale testing of these reagents and processes has demonstrated the susceptibility of the new classes of reagents to radiolytic and hydrolytic degradation. In this project, separations of trivalent actinides from fission product lanthanides have been investigated in studies of 1) the extraction and chemical stability properties of a class of soft-donor extractants that are adapted from water-soluble analogs, 2) the application of water soluble soft-donor complexing agents in tandem with conventional extractant molecules emphasizing fundamental studies of the TALSPEAK Process. This research was conducted principally in radiochemistry laboratories at Washington State University. Collaborators at the Radiological Processing Laboratory (RPL) at the Pacific Northwest National Laboratory (PNNL) have contributed their unique facilities and capabilities, and have supported student internships at PNNL to broaden their academic experience. New information has been developed to qualify the extraction potential of a class of pyridine-functionalized tetraaza complexants indicating potential single contact Am-Nd separation factors of about 40. The methodology developed for characterization will find further application in our continuing efforts to synthesize and characterize new reagents for this separation. Significant new insights into the performance envelope and supporting information on the TALSPEAK process has also been developed.« less

Radiochemistry, pre-clinical studies and first clinical investigation of 90Y-labeled hydroxyapatite (HA) particles prepared utilizing 90Y produced by (n,γ) route.

PubMed

Vimalnath, K V; Chakraborty, Sudipta; Rajeswari, A; Sarma, H D; Nuwad, Jitendra; Pandey, Usha; Kamaleshwaran, K; Shinto, Ajit; Dash, Ashutosh

2015-05-01

The scope of using no carrier added (NCA) (90)Y [T(1/2) = 64.1 h, Eβ(max) = 2.28 MeV] obtained from (90)Sr/(90)Y generator in radiation synovectomy (RSV) is widely accepted. In the present study, the prospect of using (90)Y produced by (n,γ) route in a medium flux research reactor for use in RSV was explored. Yttrium-90 was produced by thermal neutron irradiation of Y(2)O(3) target at a neutron flux of ~1×10(14) n/cm(2).s for 14 d. The influence of various experimental parameters were systematically investigated and optimized to arrive at the most favorable conditions for the formulation of (90)Y labeled hydroxyapatite (HA) using HA particles of 1-10 μm size range. An optimized kit formulation strategy was developed for convenient one-step compounding of (90)Y-HA, which is easily adaptable at hospital radiopharmacy. The pre-clinical biological evaluation of (90)Y-HA particles was studied by carrying out biodistribution and bioluminiscence imaging studies in Wistar rats. The first clinical investigation using the radiolabeled preparation was performed on a patient suffering from chronic arthritis in knee joint by administering 185 MBq (90)Y-HA formulated at the hospital radiopharmacy deploying the proposed strategy. Yttrium-90 was produced with a specific activity of 851 ± 111 MBq/mg and radionuclidic purity of 99.95 ± 0.02%. (90)Y-labeled HA particles (185 ± 10 MBq doses) were formulated in high radiochemical purity (>99%) and excellent in vitro stability. The preparation showed promising results in pre-clinical studies carried out in Wistar rats. The preliminary results of the first clinical investigation of (90)Y-HA preparation in a patient with rheumatoid arthritis in knee joints demonstrated the effectiveness of the formulation prepared using (90)Y produced via (n,γ) route in the management of the disease. The studies revealed that effective utilization of (90)Y produced via (n,γ) route in a medium flux research reactor coupled with the developed strategy of using HA kits for convenient formulation of (90)Y-HA at the hospital radiopharmacy can contribute to sustainable growth in the clinical utilization of (90)Y in RSV in the foreseeable future. Copyright © 2015 Elsevier Inc. All rights reserved.

2002 Research Reports: NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Kotnour, Tim (Editor); Black, Cassandra (Editor)

2002-01-01

This document is a collection of technical reports on research conducted by the participants in the 2002 NASA/ASEE Faculty Fellowship Program at the John F. Kennedy Space Center (KSC). This was the 18th year that a NASA/ASEE program has been conducted at KSC. The 2002 program was administered by the University of Central Florida (UCF) in cooperation with KSC. The program was operated under the auspices of the American Society for Engineering Education (ASEE) and the Education Division, NASA Headquarters, Washington, D.C. The KSC Program was one of nine such Aeronautics and Space Research Programs funded by NASA Headquarters in 2002. The KSC Faculty Fellows spent ten weeks working with NASA scientists and engineers on research of mutual interest to the university faculty member and the NASA colleague. The editors of this document were responsible for selecting appropriately qualified faculty to address some of the many research areas of current interest to NASA/KSC. The NASA/ASEE program is intended to be a two-year program to allow in-depth research by the university faculty member.

An Analysis of Research Quality and Productivity at Six Academic Orthopaedic Residencies.

PubMed

Osborn, Patrick M; Ames, S Elizabeth; Turner, Norman S; Caird, Michelle S; Karam, Matthew D; Mormino, Matthew A; Krueger, Chad A

2018-06-06

It remains largely unknown what factors impact the research productivity of residency programs. We hypothesized that dedicated resident research time would not affect the quantity and quality of a program's peer-reviewed publication within orthopedic residencies. These findings may help programs improve structure their residency programs to maximize core competencies. Three hundred fifty-nine residents and 240 staff from six different US orthopedic residency programs were analyzed. All publications published by residents and faculty at each program from January 2007 to December 2015 were recorded. SCImago Journal Rankings (SJR) were found for each journal. There were no significant differences in publications by residents at each program (p > 0.05). Faculty with 10+ years of on staff, had significantly more publications than those with less than 10years (p < 0.01). Programs with increased resident research time did not consistently produce publications with higher SJR than those without dedicated research time. Increased dedicated resident research time did not increase resident publication rates or lead to publications with higher SJR. Copyright © 2018 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

How the Build Up of Aqueous Humor Can Damage the Optic Nerve

MedlinePlus

... Alzheimer’s Disease Research Program Macular Degeneration Research Program National Glaucoma Research Program Molecular Neurodegeneration ... Foundation BrightFocus Foundation 22512 Gateway Center Drive Clarksburg, MD ...

76 FR 12717 - Disability and Rehabilitation Research Projects and Centers Program; Field Initiated (FI...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-08

... DEPARTMENT OF EDUCATION Disability and Rehabilitation Research Projects and Centers Program; Field...; National Institute on Disability and Rehabilitation Research (NIDRR)--Disability and Rehabilitation Research Projects and Centers Program--Field Initiated (FI) Projects AGENCY: Office of Special Education...

7 CFR 1221.121 - Programs, plans, and projects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Promotion... establishment, issuance, effectuation, and administration of appropriate programs for promotion, research, and... contributes to an effective program of promotion, research, or information. If it is found by the Board that...

7 CFR 1218.54 - Programs, plans, and projects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROMOTION, RESEARCH, AND INFORMATION ORDER Blueberry Promotion, Research, and Information Order Expenses and..., effectuation, and administration of appropriate programs for promotion, research, and information, including... ensure that it contributes to an effective program of promotion, research, or information. If it is found...

A distributed model: redefining a robust research subject advocacy program at the Harvard Clinical and Translational Science Center.

PubMed

Winkler, Sabune J; Cagliero, Enrico; Witte, Elizabeth; Bierer, Barbara E

2014-08-01

The Harvard Clinical and Translational Science Center ("Harvard Catalyst") Research Subject Advocacy (RSA) Program has reengineered subject advocacy, distributing the delivery of advocacy functions through a multi-institutional, central platform rather than vesting these roles and responsibilities in a single individual functioning as a subject advocate. The program is process-oriented and output-driven, drawing on the strengths of participating institutions to engage local stakeholders both in the protection of research subjects and in advocacy for subjects' rights. The program engages stakeholder communities in the collaborative development and distributed delivery of accessible and applicable educational programming and resources. The Harvard Catalyst RSA Program identifies, develops, and supports the sharing and distribution of expertise, education, and resources for the benefit of all institutions, with a particular focus on the frontline: research subjects, researchers, research coordinators, and research nurses. © 2014 Wiley Periodicals, Inc.

The 1995 Research Reports: NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Hosler, E. Ramon (Editor); Buckingham, Gregg (Editor)

1995-01-01

This document is a collection of technical reports on research conducted by the participants in the 1995 NASA/ASEE Summer Faculty Fellowship Program at the Kennedy Space Center (KSC). This was the eleventh year that a NASA/ASEE program has been conducted at KSC. The 1995 program was administered by the University of Central Florida in cooperation with KSC. The program was operated under the auspices of the American Society for Engineering Education (ASEE) with sponsorship and funding from the Office of Educational Affairs, NASA Headquarters, Washington, D.C. The KSC Program was one of nine such Aeronautics and Space Research Programs funded by NASA Headquarters in 1995. The NASA/ASEE Program is intended to be a two-year program to allow in-depth research by the University faculty member.

7 CFR 1150.153 - Qualified dairy product promotion, research or nutrition education programs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... nutrition education programs. 1150.153 Section 1150.153 Agriculture Regulations of the Department of... Qualified dairy product promotion, research or nutrition education programs. (a) Any producer organization that conducts a State or regional dairy product promotion, research or nutrition education program...

7 CFR 1150.153 - Qualified dairy product promotion, research or nutrition education programs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... nutrition education programs. 1150.153 Section 1150.153 Agriculture Regulations of the Department of... Qualified dairy product promotion, research or nutrition education programs. (a) Any producer organization that conducts a State or regional dairy product promotion, research or nutrition education program...

7 CFR 1150.153 - Qualified dairy product promotion, research or nutrition education programs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... nutrition education programs. 1150.153 Section 1150.153 Agriculture Regulations of the Department of... Qualified dairy product promotion, research or nutrition education programs. (a) Any producer organization that conducts a State or regional dairy product promotion, research or nutrition education program...

77 FR 28887 - Office of the Director, National Institutes of Health, Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... Assistance Program Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment... Research Loan Repayment Program; 93.187, Undergraduate Scholarship Program for Individuals from.../Outreach Program Specialist, Office of Communications and Public Liaison, Office of the Director, National...

75 FR 63493 - Office of the Director, National Institutes of Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... Assistance Program Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment... Research Loan Repayment Program; 93.187, Undergraduate Scholarship Program for Individuals from..., Executive Secretary/Outreach Program Specialist, Office of Communications and Public Liaison, Office of the...

Teaching Global Change in Local Places: The HERO Research Experiences for Undergraduates Program

ERIC Educational Resources Information Center

Yarnal, Brent; Neff, Rob

2007-01-01

The Human-Environment Research Observatory (HERO) Research Experience for Undergraduates (REU) program aimed to develop the next generation of researchers working on place-based human-environment problems. The program followed a cooperative learning model to foster an integrated approach to geographic research and to build collaborative research…

Forest productivity: an integrated research and development program

Treesearch

Daniel C. Dey; Thomas R. Crow; Don E. Riemenschneider

2003-01-01

In 2000, the North Central Research Station initiated the Forest Productivity Integrated Research Program (North Central Research Station 2001). This program combines the efforts of scientists from across the Station's 13 research work units to examine the current condition of the forests in the North Central Region and their prospects for producing wood and fiber...

Pediatric Oncology Branch - Psychosocial Support and Research Program-Science | Center for Cancer Research

Cancer.gov

Psychosocial Support & Research Program Research is another critical component of the psychosocial program. Our research studies are designed to learn how to best help patients and their families prepare for, adjust to, and cope with the effects of cancer and other related medical conditions while enrolled on research protocols in several NCI Branches and NIH Institutes.  

NASULGC Council on Extension, Committee on Program Innovation and Action Oriented Research; 1968 Report. Part 1. Program Innovations. Part 2. Action Oriented Research.

ERIC Educational Resources Information Center

National Association of State Universities and Land Grant Colleges, Washington, DC.

This report on extension activities of member institutions of the National Association of State Universities and Land Grant Colleges describes 91 program innovations and action oriented research activities. Objectives, sponsorship, program evaluations, and other data are cited for program innovations in such areas as continuing medical education,…

Social multiplier effects: academics' and practitioners' perspective on the benefits of a tuberculosis operational research capacity-building program in Indonesia.

PubMed

Probandari, Ari; Mahendradhata, Yodi; Widjanarko, Bagoes; Alisjahbana, Bachti

2017-01-01

The Tuberculosis Operational Research Group (TORG) implemented a capacity-building model involving academics and practitioners (i.e. clinicians or program staff) in an operational research (OR) team in Indonesia. This study explored academics' and practitioners' perspectives regarding the benefits of participating in a tuberculosis (TB) OR capacity-building program in Indonesia. We conducted a qualitative study involving in-depth interviews with 36 academics and 23 practitioners undertaking the TORG capacity-building program. We asked open-ended questions about their experience of the program. Data were analyzed via content analysis. The findings demonstrated the social multiplier effects of the OR capacity-building program. Both academics and practitioners reported perceived improvements in research knowledge, skills, and experience, and described additional individual- and institutional-level benefits. The individual-level benefits level included improvements in understanding of the TB program, motivation for research and self-satisfaction, the development/enhancement of individual networking, receipt of recognition, and new opportunities. The additional benefits reported at an institutional level included improvement in research curricula, in-house training, and program management and the development/enhancement of institutional partnerships. The program improved not only individuals' capacity for conducting OR but also the quality of the TB program management and public health education. OR should be included in research methodology curricula for postgraduate public health/disease control programs. The capacity-building model, in which academics and program staff collaborated within an OR team, should be promoted.

NASA gear research and its probable effect on rotorcraft transmission design

NASA Technical Reports Server (NTRS)

Zaretsky, E. V.; Townsend, D. P.; Coy, J. J.

1979-01-01

The NASA Lewis Research Center devised a comprehensive gear technology research program beginning in 1969, the results of which are being integrated into the NASA civilian Helicopter Transmission System Technology Program. Attention is given to the results of this gear research and those programs which are presently being undertaken. In addition, research programs studying pitting fatigue, gear steels and processing, life prediction methods, gear design and dynamics, elastohydrodynamic lubrication, lubrication methods and gear noise are presented. Finally, the impact of advanced gear research technology on rotorcraft transmission design is discussed.

1998 NASA-HU American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Marable, William P. (Compiler); Murray, Deborah B. (Compiler)

1998-01-01

Since 1964, the National Aeronautics and Space Administration (NASA) has supported a program of summer faculty fellowships for engineering and science educators. In a series of collaborations between NASA research and development centers and nearby universities, engineering faculty members spend 10 weeks working with professional peers on research. The Summer Faculty Program Committee of the American Society for Engineering Education supervises the programs. The program objectives include: (1) To further the professional knowledge of qualified engineering and science faculty members; (2) To stimulate and exchange ideas between participants and NASA; (3) To enrich and refresh the research and teaching activities of participants' institutions; (4) To contribute to the research objectives of the NASA center. College or university faculty members will be appointed as Research Fellows to spend 10 weeks in cooperative research and study at the NASA Langley Research Center. The Fellow will devote approximately 90 percent of the time to a research problem and the remaining time to a study program. The study program will consist of lectures and seminars on topics of interest or that are directly relevant to the Fellows' research topics. The lecture and seminar leaders will be distinguished scientists and engineers from NASA, education, and industry.

2001 NASA-ODU American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Tiwari, Surendra N. (Compiler); Murray, Deborah B. (Compiler); Hathaway, Roger A. (Technical Monitor)

2002-01-01

Since 1964, the National Aeronautics and Space Administration (NASA) has supported a program of summer faculty fellowships for engineering and science educators. In a series of collaborations between NASA research and development centers and nearby universities, engineering faculty members spend 10 weeks working with professional peers on research. The Summer Faculty Program Committee of the American Society for Engineering Education supervises these programs. Objectives: (1) To further the professional knowledge of qualified engineering and science faculty members; (2) To stimulate and exchange ideas between participants and NASA; (3) To enrich and refresh the research and teaching activities of participants' institutions; (4 To contribute to the research objectives of the NASA center. Program Description: College or university faculty members will be appointed as Research Fellows to spend 10 weeks in cooperative research and study at the NASA Langley Research Center. The Fellow will devote approximately 90 percent of the time to a research problem and the remaining time to a study program. The study program will consist of lectures and seminars on topics of interest or that are directly relevant to the Fellow's research topics. The lecture and seminar leaders wil be distinguished scientists and engineers from NASA, education and industry.

1996 NASA-Hampton University American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Spencer, John H. (Compiler); Young, Deborah B. (Compiler)

1996-01-01

NASA has supported a program of summer faculty fellowships for engineering and science educators. In a series of collaborations between NASA research and development centers and nearby universities, engineering faculty members spend 10 weeks working with professional peers on research. The Summer Faculty Program Committee of the American Society for Engineering Education supervises the programs. The objectives were: (1) To further the professional knowledge of qualified engineering and science faculty members; (2) To stimulate and exchange ideas between participants and NASA; (3) To enrich and refresh the research and teaching activities of participants institutions; (4) To contribute to the research objectives of the NASA Center. Program Description: College or university faculty members will be appointed as Research Fellows to spend 10 weeks in cooperative research and study at the NASA Langley Research Center. The Fellow will devote approximately 90 percent of the time to a research problem and the remaining time to a study program. The study program will consist of lectures and seminars on topics of interest or that are directly relevant to the Fellows' research topics. The lectures and seminar leaders will be distinguished scientists and engineers from NASA, education, or industry.

1999 NASA - ODU American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Tiwari, Surendra N. (Compiler); Murray, Deborah B. (Compiler)

2000-01-01

Since 1964, the National Aeronautics and Space Administration (NASA) has supported a program or summer faculty fellowships for engineering and science educators. In a series of collaborations between NASA research and development centers and nearby universities, engineering faculty members spend 10 weeks working with professional peers on research. The Summer Faculty Program Committee of the American Society for Engineering Education supervises the programs. Objectives: (1) To further the professional knowledge of qualified engineering and science faculty members; (2) To stimulate and exchange ideas between participants and NASA; (3) To enrich and refresh the research and teaching activities of participants' institutions; (4) To contribute to the research objectives of the NASA center. Program Description: College or university faculty members will be appointed as Research Fellows to spend 10 weeks in cooperative research and study at the NASA Langley Research Center. The Fellow will devote approximately 90 percent of the time to a research problem and the remaining time to a study program. The study program will consist of lectures and seminars on topics of interest or that are directly relevant to the Fellows' research topics. The lecture and seminar leaders will be distinguished scientists and engineers from NASA, education, and industry.

Space and nuclear research and technology

NASA Technical Reports Server (NTRS)

1975-01-01

A fact sheet is presented on the space and nuclear research and technology program consisting of a research and technology base, system studies, system technology programs, entry systems technology, and experimental programs.

A Program of Research and Education in Astronautics at the NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Tolson, Robert H.

2000-01-01

The objectives of the Program were to conduct research at the NASA Langley Research Center in the area of astronautics and to provide a comprehensive education program at the Center leading to advanced degrees in Astronautics. We believe that the program has successfully met the objectives and has been of significant benefit to NASA LaRC, the GWU and the nation.

Federal Early Childhood Programs: A Description and Analysis of Research, Child Care, State Grant and Teacher Training Programs Pertaining to Young Children. Interim Report.

ERIC Educational Resources Information Center

Searcy, Ellen Ouhl

The main objectives of this report about the Federal effort in early learning research are to assist the National Program on Early Childhood Education (NPECE) in planning its research and development program, to identify predicted "popular" areas of research for the future, and to identify possible NPECE funding sources. The report…

United States Air Force Summer Faculty Research Program (1986). Program Management Report

DTIC Science & Technology

1986-12-01

become better acquainted with experimental techniques. Obtained new insights into aerodynamic research programs of interest to the Air Force. Broadened his...Provided in-depth analysis and new insights into aerodynamic data. He looked at some new radiations that we are considering for use with printed circuit...1979-1983 period through an AFOSR Minigrant Program. On 1 September 1983, AFOSR replaced the Minigrant Program with a new Research Initiation Program

Interventions to support and develop clinician-researcher leadership in one health district.

PubMed

Fry, Margaret; Dombkins, Anthony

2017-07-10

Purpose Clinical leadership, researcher capacity and a culture of clinical inquiry are needed in the clinical workforce. The purpose of this paper is to report on a program which was used to develop and support clinicians to explore practice, implement innovation, translate evidence and build researcher capacity. Design/methodology/approach This pragmatic paper presents a case study of a nursing and midwifery clinician-researcher development program. The multi-site, multi-modal program focused on education, mentoring and support, communication networks, and clinician-university partnerships strategies to build workforce capacity and leadership. Findings Over 2,000 staff have been involved in the program representing a range of health disciplines. The study day program has been delivered to 500 participants with master classes having over 1,500 attendees. The research mentor program has demonstrated that participants increased their confidence for research leadership roles and are pursuing research and quality assurance projects. Communication strategies improved the visibility of nursing and midwifery. Research limitations/implications This case study was conducted in one health district, which may not have relevance to other geographical areas. The small numbers involved in the research mentor program need to be considered when reviewing the findings. Practical implications The program has been a catalyst for developing a research culture, clinical leadership and research networks that strengthen workforce capacity. Building researcher skills in the workforce will better support quality healthcare and the examination of everyday practice. Social implications Building a culture of healthcare that is based on inquiry and evidence-based practice will lead to more appropriate and consistent healthcare delivery. Consumers have the right to expect health clinicians will challenge everyday practice and have the skills and capability to translate or generate best evidence to underpin professional and service delivery. Originality/value This paper provides strategies for building workforce researcher capacity and capability. The program provides opportunity for building research networks and role modeling the value and importance of research to practice and quality improvement.

Liver Biopsy

MedlinePlus

... Funding Current Funding Opportunities Research Programs & Contacts Human Subjects Research Funding Process Research Training & Career Development Funded ... Funding Current Funding Opportunities Research Programs & Contacts Human Subjects Research Funding Process Research Training & Career Development Funded ...

Perceived Value of Required Research in Orthodontic Postgraduate Programs.

ERIC Educational Resources Information Center

Lancaster, Diana M.; And Others

Graduates' perceptions concerning the value of required research experience in orthodontic postdoctoral programs were determined. Factors in the postdoctoral research program that provided positive/negative experiences were also identified. Fifteen attitude statements concerning the merits of required research projects and demographic items on the…

78 FR 15022 - Office of the Director, National Institutes of Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-08

... Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment Program for... Program; 93.187, Undergraduate Scholarship Program for Individuals from Disadvantaged Backgrounds..., Director of Scientific and Program Operations, Office of Aids Research, Office of the Director, NIH, 5635...

34 CFR 660.1 - What is the International Research and Studies Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... outcomes and effectiveness of supported programs; (f) Comparative studies of the effectiveness of... 34 Education 3 2012-07-01 2012-07-01 false What is the International Research and Studies Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM...

34 CFR 660.1 - What is the International Research and Studies Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... outcomes and effectiveness of supported programs; (f) Comparative studies of the effectiveness of... 34 Education 3 2013-07-01 2013-07-01 false What is the International Research and Studies Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM...

34 CFR 660.1 - What is the International Research and Studies Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... outcomes and effectiveness of supported programs; (f) Comparative studies of the effectiveness of... 34 Education 3 2014-07-01 2014-07-01 false What is the International Research and Studies Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM...

34 CFR 660.1 - What is the International Research and Studies Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... outcomes and effectiveness of supported programs; (f) Comparative studies of the effectiveness of... 34 Education 3 2011-07-01 2011-07-01 false What is the International Research and Studies Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM...

34 CFR 660.1 - What is the International Research and Studies Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... outcomes and effectiveness of supported programs; (f) Comparative studies of the effectiveness of... 34 Education 3 2010-07-01 2010-07-01 false What is the International Research and Studies Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM...

Western Mountain Initiative - Research Links

Science.gov Websites

Parks programS Forest Service Climate Change Resource Center (CCRC) North American Nitrogen Center to be told." US Global Change Research Program (GlobalChange.gov) USGS Climate and Land Use Rocky Mountain Science Center Global Change Research Program -- A Focus on Mountain Ecosystems Western

7 CFR 1150.109 - Qualified program.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AGREEMENTS AND ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.109 Qualified program. Qualified program means any dairy product promotion, research or nutrition education program which is certified as a qualified program pursuant to § 1150.153...

7 CFR 1150.109 - Qualified program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.109 Qualified program. Qualified program means any dairy product promotion, research or nutrition education program which is certified as a qualified program pursuant to § 1150.153...

7 CFR 1150.109 - Qualified program.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AGREEMENTS AND ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.109 Qualified program. Qualified program means any dairy product promotion, research or nutrition education program which is certified as a qualified program pursuant to § 1150.153...

Creating a Research-Rich Curriculum at Miami University

NASA Astrophysics Data System (ADS)

Rauckhorst, William H.

2007-10-01

Miami University has attempted in recent years to build upon a collection of individual student research participation opportunities at the University, and develop a comprehensive ``research-rich'' undergraduate curriculum. A major step in this direction was the creation of the Undergraduate Summer Scholars (USS) program. This program provides 10-week summer research experiences with faculty mentors for 100 juniors or seniors each year. The USS Program is not limited to science and engineering areas, as approximately 30 academic departments participate annually. Development of the USS program at Miami was motivated by the University's prior experience with student research appointments funded by the National Science Foundation, the Howard Hughes Medical Institute, and other sponsoring agencies. The University's evaluation of these earlier student research experiences provided evidence that such experiences were at least as significant in a student's education as formal course work. A second important step in Miami's effort was obtaining a grant from the National Science Foundation's Comprehensive Reform of Undergraduate Education program. This funding enabled the University to enhance the Undergraduate Summer Scholars (USS) Program and evaluate student intellectual growth within the program. Two outcomes of this NSF-funded project are noteworthy: first, the USS program now is firmly established within the University's offerings; second, the evaluation ndicated profound student intellectual growth as a result of mentored research experiences. We will describe the development of the Undergraduate Summer Scholars Program, our evaluation of the Program, and ongoing efforts to extend the benefits of research experience to more students by incorporating research components within traditional coursework.

Health economics and outcomes research fellowship practices reviewed.

PubMed

Suh, Kangho; Gabriel, Susan; Adams, Michelle A; Arcona, Steve

2015-01-01

The guidelines for health economics and outcomes research (HEOR) fellowship training programs devised by the American College of Clinical Pharmacy (ACCP) and the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) suggest that continuous improvements are made to ensure that postgraduate training through didactic and professional experiences prepare fellows for HEOR research careers. The HEOR Fellowship Program at Novartis Pharmaceuticals Corporation was standardized to enhance the fellows' HEOR research understanding and align professional skill sets with the ACCP-ISPOR Fellowship Program Guidelines. Based on feedback from an internal task force comprised of HEOR employees and current and former fellows, the HEOR Fellowship Program was normatively and qualitatively assessed to evaluate the current curricular program. Fellowship program activities were instituted to ensure that the suggested minimum level requirements established by the guidelines were being met. Research opportunities enabling fellows to work hand-in-hand with other fellows and HEOR professionals were emphasized. Curricular enhancements in research methodology and professional training and development, and materials for a structured journal club focusing on specific methodological and HEOR research topics were developed. A seminar series (e.g., creating SMART Goals, StrengthsFinder 2.0) and professional courses (e.g., ISPOR short courses, statistics.com) were included to enhance the fellows' short- and long-term professional experience. Additional program attributes include an online reference library developed to enrich the current research facilities and a Statistical Analysis Software training program. Continuously assessing and updating HEOR fellowship programs keeps programs up-to-date in the latest HEOR concepts and approaches used to evaluate health care, both professionally and educationally. Copyright © 2015 Elsevier Inc. All rights reserved.

Cleveland Clinic's summer research program in reproductive medicine: an inside look at the class of 2014

PubMed Central

Durairajanayagam, Damayanthi; Kashou, Anthony H; Tatagari, Sindhuja; Vitale, Joseph; Cirenza, Caroline; Agarwal, Ashok

2015-01-01

Background The American Center for Reproductive Medicine's summer internship course in reproductive medicine and research at Cleveland Clinic is a rigorous, results-oriented annual program that began in 2008 to train both local and international students in the fundamentals of scientific research and writing. The foremost goal of the program is to encourage premedical and medical students to aspire toward a career as a physician–scientist. The internship provides participants with an opportunity to engage in original bench research and scientific writing while developing theoretical knowledge and soft skills. This study describes selected survey responses from interns who participated in the 2014 internship program. The objective of these surveys was to elicit the interns' perspective on the internship program, its strengths and weaknesses, and to obtain insight into potential areas for improvement. Methods Questionnaires were structured around the five fundamental aspects of the program: 1) theoretical knowledge, 2) bench research, 3) scientific writing, 4) mentorship, and 5) soft skills. In addition, an exit survey gathered information on factors that attracted the interns to the program, communication with mentors, and overall impression of the research program. Results The opportunity to experience hands-on bench research and scientific writing, personalized mentorship, and the reputation of the institution were appreciated and ranked highly among the interns. Nearly 90% of the interns responded that the program was beneficial and well worth the time and effort invested by both interns and faculty. Conclusion The outcomes portrayed in this study will be useful in the implementation of new programs or refinement of existing medical research training programs. PMID:26563960

Fifteen years of occupational and environmental health projects support in Brazil, Chile, and Mexico: a report from Mount Sinai School of Medicine ITREOH program, 1995-2010.

PubMed

Peres, Frederico; Claudio, Luz

2013-01-01

The Fogarty International Center of the National Institutes of Health created the International Training and Research Program in Occupational and Environmental Health (ITREOH program) in 1995 with the aim to train environmental and occupational health scientists in developing countries. Mount Sinai School of Medicine was a grantee of this program since its inception, partnering with research institutions in Brazil, Chile, and Mexico. This article evaluates Mount Sinai's program in order to determine whether it has contributed to the specific research capacity needs of the international partners. Information was obtained from: (a) international and regional scientific literature databases; (b) databases from the three participating countries; and (c) MSSM ITREOH Program Database. Most of the research projects supported by the program were consistent with the themes found to be top priorities for the partner countries based on mortality/morbidity and research themes in the literature. Indirect effects of the training and the subsequent research projects completed by the trained fellows in the program included health policy changes and development of collaborative international projects. International research training programs, such as the MSSM ITREOH, that strengthen scientific research capacity in occupational and environmental health in Latin America can make a significant impact on the most pressing health issues in the partner countries. Copyright © 2012 Wiley Periodicals, Inc.

7 CFR 1210.311 - Programs and projects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROMOTION PLAN Watermelon Research and Promotion Plan Definitions § 1210.311 Programs and projects. Programs and projects mean those research, development, advertising, or promotion programs or projects...

Path to a Research Plan

NASA Technical Reports Server (NTRS)

Chiaramonte, Fran

2003-01-01

This viewgraph presentation discusses the status and goals for the NASA OBPR Physical Science Research Program. The following text was used to summarize the presentation. The OBPR Physical Sciences Research program has been comprehensively reviewed and endorsed by National Research Council. The value and need for the research have been re-affirmed. The research program has been prioritized and resource re-allocations have been carried out through an OBPR-wide process. An increasing emphasis on strategic, mission-oriented research is planned. The program will strive to maintain a balance between strategic and fundamental research. A feasible ISS flight research program fitting within the budgetary and ISS resource envelopes has been formulated for the near term (2003-2007). The current ISS research program will be significantly strengthened starting 2005 by using discipline dedicated research facility racks. A research re-planning effort has been initiated and will include active participation from the research community in the next few months. The research re-planning effort will poise PSR to increase ISS research utilization for a potential enhancement beyond ISS IP Core Complete. The Physical Sciences research program readily integrates the cross-disciplinary requirements of the NASA and OBPR strategic objectives. Each fundamental research thrust will develop a roadmap through technical workshops and Discipline Working Groups (DWGs). Most fundamental research thrusts will involve cross-disciplinary efforts. A Technology Roadmap will guide the Strategic Research for Exploration thrust. The Research Plan will integrate and coordinate fundamental Research Thrusts Roadmaps with the Technology Roadmap. The Technology Roadmap will be developed in coordination with other OBPR programs as well as other Enterprise (R,S,M,N). International Partners will contribute to the roadmaps and through research coordination. The research plan will be vetted with the discipline working groups, the BPRAC subcommittees, and with the BPRAC. Recommendations from NRC past and current committees will be implemented whenever appropriate.Proposed theme element content will be "missionized" around planned content and potential new projects (facilities, modules, initiatives) on approximately a five-year horizon, with the approval of PSRD management. Center/science working group teams will develop descriptions of "mission" objectives, value, and requirements. Purpose is to create a competitive environment for concept development and to stimulate community ownership/advocacy. Proposed theme elements reviewed and approved by PSRD management. Strawman roadmaps for themes developed. Program budget and technology requirements verified. Theme elements are prioritized with the input of advisory groups. Integration into program themes (questions) and required technology investments are defined by science and technology roadmaps. Review and assessment by OBPR management.

Emergency Medicine Resources within the Clinical Translational Science Institutes: A Cross-Sectional Study

PubMed Central

Meurer, William J.; Quinn, James; Lindsell, Christopher; Schneider, Sandra; Newgard, Craig D.

2016-01-01

Background The Clinical and Translational Science Award (CTSA) program aims to strengthen and support translational research by accelerating the process of translating laboratory discoveries into treatments for patients, training a new generation of clinical and translational researchers, and engaging communities in clinical research efforts. Yet, little is known about how emergency care researchers have interacted with and utilized the resources of academic institutions with CTSAs. Objective The purpose of this survey was to describe how emergency care researchers use local CTSA resources, to ascertain what proportion of CTSA consortium members have active emergency care research programs, and to solicit participation in a national CTSA-associated emergency care translational research network. Methods Survey of all emergency departments affiliated with a CTSA. Results Of the 65 CTSA consortium members, three had no emergency care research program and we obtained responses from 46 of the remaining 62 (74% response rate). The interactions with and resources used by emergency care researchers varied widely. Methodology and biostatistics support was most frequently accessed (77%), followed closely by education and training programs (60%). Several emergency care research programs (76%) had submitted for funding through CTSAs, with 71% receiving awards. Most CTSA consortium members had an active emergency care research infrastructure: 21 (46%) had 24/7 availability to recruit and screen for research, 21 (46%) had less than 24/7 research recruitment. A number of emergency care research programs participated in NIH research networks with the Neurological Emergencies Treatment Trials network most highly represented with 23 (59%) sites. Most emergency care research programs (96%) were interested in participating in a CTSA-based emergency care translational research network. Conclusions Despite little initial involvement in development of the CTSA program, there has been moderate interaction between CTSAs and emergency care. There is considerable interest in participating in a CTSA consortium based emergency care translational research network. PMID:26826059

NASA Early Career Fellowship Program

NASA Astrophysics Data System (ADS)

Smith, H. D.

2012-12-01

The Early Career Fellowship program was established in 2005 to facilitate the integration of outstanding early career planetary science researchers into established research funding programs by providing tools and experience useful to maintain a successful research program. Executing a successful research program requires a few key elements such as: successful proposal writing; adequate (paid) research time; management of a laboratory; collaboration and networking; frequent and high-quality publications; and adequate start-up equipment funds. These elements may be particularly critical for early career researchers searching for a tenure- track or equivalent position. The Early Career Fellowship program recognizes the importance of these skills and provides extra funding and resources to begin a successful research program. For consideration into The Early Career Fellowship program, the candidate needs to be the P. I. or Science P.I. of a funded research proposal from one of the participating R&A program areas, be within 7 years of earning a PhD, hold a non-tenure track position, and indicate the early career candidacy when submitting the research proposal. If the research proposal is funded and the discipline scientist nominates the candidate as an early career fellow, the candidate is then considered a Fellow and eligible to propose for Step 2. Upon obtaining a tenure-track equivalent position the Fellow submits a Step 2 proposal for up to one hundred thousand dollars in start-up funds. Start-up funds may be used for salary; undergraduate and/or graduate research assistants; supplies and instrument upgrades; travel to conferences, meetings, and advisory groups; time and travel for learning new skills; publication page charges; books and journal subscriptions; computer time and/or specialized software; and other justified research-specific needs. The early career fellowship program provides resources that a more established scientist would have acquired allowing the Fellow to be a better job applicant. NASA opportunities from the undergraduate to postdoctoral level are also discussed.

Building Innovation and Sustainability in Programs of Research.

PubMed

Villarruel, Antonia M

2018-01-01

Innovation and sustainability are two important concepts of impactful programs of research. While at first glance these concepts and approaches may seem at odds, they are synergistic. We examine the social, political, and policy context as it relates to innovation and sustainability. We present an exemplar of a program of research and discuss factors to consider in developing innovative and sustainable programs of research. Innovation is an important component of sustainable programs of research. Understanding the social and political context and addressing relevant policy issues are factors to be considered in both innovation and sustainability. Innovation and sustainability, important components of research, are also central to clinical practice. Open communication between researchers and clinicians can support the acceleration of innovations and the integration of evidence-based findings in practice. © 2017 Sigma Theta Tau International.

Educating nurses about research ethics and practices with a self-directed practice-based learning program.

PubMed

Cibulka, Nancy J

2011-11-01

Learner-driven and practice-based education programs are recommended for integration of learning. A continuing education program on research ethics was introduced to five nurses in an ambulatory care setting at a Magnet® hospital, using a commercially available web-based course followed by a research practicum. The seasoned nurses reported little previous education in this area. Working with a nurse researcher, three nurses participated in a research project for improving clinic care delivery. The success of the continuing education program was determined by knowledge acquisition, satisfaction with learning activities, and perceived confidence in research participation. This continuing education program was effective in providing for knowledge and skill development in research ethics. The integrative learning format was well received. Copyright 2011, SLACK Incorporated.

USDA Forest Service, Pacific Southwest Research Station Sudden Oak Death Research Program: 2001-2005

Treesearch

Patrick J. Shea

2006-01-01

The Pacific Southwest Research Station (PSW), U.S. Department of Agriculture (USDA) Forest Service initiated the Sudden Oak Death Research (SOD) Program in late 2000. The program was prompted by late fiscal year funding dedicated directly to begin research on this newly discovered disease. The history of discovery of Phytophthora ramorum, the...

Motivations of Educators for Participating in an Authentic Astronomy Research Experience Professional Development Program

ERIC Educational Resources Information Center

Rebull, L. M.; Roberts, T.; Laurence, W.; Fitzgerald, M. T.; French, D. A.; Gorjian, V.; Squires, G. K.

2018-01-01

[This paper is part of the Focused Collection on Astronomy Education Research.] The NASA/IPAC Teacher Archive Research Program (NITARP) partners small groups of educators with a research astronomer for a year-long authentic research project. This program aligns well with the characteristics of high-quality professional development (PD) programs…

The Costs of Commonality: Examination of the JLTV as a Case Study

DTIC Science & Technology

2016-07-15

Acquisition Research Program Graduate School of Business & Public Policy Naval Postgraduate School NPS-16-AM-151 ACQUISITION RESEARCH ... Research Program Graduate School of Business & Public Policy Naval Postgraduate School The research ...presented in this report was supported by the Acquisition Research Program of the Graduate School of Business & Public Policy at the Naval

The Center for Aerospace Research: A NASA Center of Excellence at North Carolina Agricultural and Technical State University

NASA Technical Reports Server (NTRS)

Lai, Steven H.-Y.

1992-01-01

This report documents the efforts and outcomes of our research and educational programs at NASA-CORE in NCA&TSU. The goal of the center was to establish a quality aerospace research base and to develop an educational program to increase the participation of minority faculty and students in the areas of aerospace engineering. The major accomplishments of this center in the first year are summarized in terms of three different areas, namely, the center's research programs area, the center's educational programs area, and the center's management area. In the center's research programs area, we focus on developing capabilities needed to support the development of the aerospace plane and high speed civil transportation system technologies. In the educational programs area, we developed an aerospace engineering option program ready for university approval.

Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology into NASA Programs Associated with the Aeronautics Research Mission Directorate

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2015-01-01

This report is intended to help NASA program and project managers incorporate Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) technologies that have gone through Phase II of the SBIR program into NASA Aeronautics and Mission Directorate (ARMD) programs. Other Government and commercial program managers can also find this information useful.

76 FR 15964 - Funding Priorities: Disability and Rehabilitation Research Projects and Centers Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... past five years, the DBTACs have published numerous journal articles, held a series of research... and Rehabilitation Research Projects and Centers Program AGENCY: Office of Special Education and... Disability and Rehabilitation Research Projects and Centers Program administered by the National Institute on...

NASA LANGLEY RESEARCH CENTER AND THE TIDEWATER INTERAGENCY POLLUTION PREVENTION PROGRAM

EPA Science Inventory

National Aeronautics and Space Administration (NASA)'s Langley Research Center (LaRC) is an 807-acre research center devoted to aeronautics and space research. aRC has initiated a broad-based pollution prevention program guided by a Pollution Prevention Program Plan and implement...

Towards a Lakatosian Analysis of the Piagetian and Alternative Conceptions Research Programs.

ERIC Educational Resources Information Center

Gilbert, John K.; Swift, David J.

1985-01-01

Lakatos's methodology of scientific research programs is summarized and discussed for Piagetian schools and alternative conceptions movement. Commonalities/differences between these two rival programs are presented along with fundamental assumptions, auxiliary hypotheses, and research policy. Suggests that research findings should not be merely…

Critical Measurement Issues in Translational Research

ERIC Educational Resources Information Center

Glasgow, Russell E.

2009-01-01

This article summarizes critical evaluation needs, challenges, and lessons learned in translational research. Evaluation can play a key role in enhancing successful application of research-based programs and tools as well as informing program refinement and future research. Discussion centers on what is unique about evaluating programs and…

Building up careers in translational neuroscience and mental health research: Education and training in the Centre for Biomedical Research in Mental Health.

PubMed

Rapado-Castro, Marta; Pazos, Ángel; Fañanás, Lourdes; Bernardo, Miquel; Ayuso-Mateos, Jose Luis; Leza, Juan Carlos; Berrocoso, Esther; de Arriba, Jose; Roldán, Laura; Sanjuán, Julio; Pérez, Victor; Haro, Josep M; Palomo, Tomás; Valdizan, Elsa M; Micó, Juan Antonio; Sánchez, Manuel; Arango, Celso

2015-01-01

The number of large collaborative research networks in mental health is increasing. Training programs are an essential part of them. We critically review the specific implementation of a research training program in a translational Centre for Biomedical Research in Mental Health in order to inform the strategic integration of basic research into clinical practice to have a positive impact in the mental health system and society. Description of training activities, specific educational programs developed by the research network, and challenges on its implementation are examined. The Centre for Biomedical Research in Mental Health has focused on training through different activities which have led to the development of an interuniversity master's degree postgraduate program in mental health research, certified by the National Spanish Agency for Quality Evaluation and Accreditation. Consolidation of training programs within the Centre for Biomedical Research in Mental Health has considerably advanced the training of researchers to meet competency standards on research. The master's degree constitutes a unique opportunity to accomplish neuroscience and mental health research career-building within the official framework of university programs in Spain. Copyright © 2014 SEP y SEPB. Published by Elsevier España. All rights reserved.

Enhancing the Careers of Under-Represented Junior Faculty in Biomedical Research: The Summer Institute Program to Increase Diversity (SIPID).

PubMed

Rice, Treva K; Liu, Li; Jeffe, Donna B; Jobe, Jared B; Boutjdir, Mohamed; Pace, Betty S; Rao, Dabeeru C

2014-01-01

The Summer Institute Program to Increase Diversity (SIPID) in Health-Related Research is a career advancement opportunity sponsored by the National Heart, Lung, and Blood Institute. Three mentored programs address difficulties experienced by junior investigators in establishing independent research careers and academic advancement. Aims are to increase the number of faculty from under-represented minority groups who successfully compete for external research funding. Data were collected using a centralized data-entry system from three Summer Institutes. Outcomes include mentees' satisfaction rating about the program, grant and publications productivity and specific comments. Fifty-eight junior faculty mentees (38% male) noticeably improved their rates of preparing/submitting grant applications and publications, with a 18-23% increase in confidence levels in planning and conducting research. According to survey comments, the training received in grantsmanship skills and one-on-one mentoring were the most valuable program components. The SIPID mentoring program was highly valued by the junior faculty mentees. The program will continue in 2011-2014 as PRIDE (PRogram to Increase Diversity among individuals Engaged in health-related research). Long-term follow-up of current mentees will be indexed at five years post training (2013). In summary, these mentoring programs hope to continue increasing the diversity of the next generation of scientists in biomedical research.

An intensive primary-literature-based teaching program directly benefits undergraduate science majors and facilitates their transition to doctoral programs.

PubMed

Kozeracki, Carol A; Carey, Michael F; Colicelli, John; Levis-Fitzgerald, Marc; Grossel, Martha

2006-01-01

UCLA's Howard Hughes Undergraduate Research Program (HHURP), a collaboration between the College of Letters and Science and the School of Medicine, trains a group of highly motivated undergraduates through mentored research enhanced by a rigorous seminar course. The course is centered on the presentation and critical analysis of scientific journal articles as well as the students' own research. This article describes the components and objectives of the HHURP and discusses the results of three program assessments: annual student evaluations, interviews with UCLA professors who served as research advisors for HHURP scholars, and a survey of program alumni. Students indicate that the program increased their ability to read and present primary scientific research and to present their own research and enhanced their research experience at UCLA. After graduating, they find their involvement in the HHURP helped them in securing admission to the graduate program of their choice and provided them with an advantage over their peers in the interactive seminars that are the foundation of graduate education. On the basis of the assessment of the program from 1998-1999 to 2004-2005, we conclude that an intensive literature-based training program increases student confidence and scientific literacy during their undergraduate years and facilitates their transition to postgraduate study.

Prostate Cancer Research Training Program

DTIC Science & Technology

2017-09-01

Award Number: W81XWH-16-1-0549 TITLE: Prostate Cancer Research Training Program PRINCIPAL INVESTIGATOR: David M. Lubaroff, PhD CONTRACTING...ORGANIZATION: University of Iowa Iowa City, IA 52242 REPORT DATE: September 2017 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research ...Prostate Cancer Research Training Program 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-16-1-0549 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S

PVAMU/XULA/BCM Summer Prostate Cancer Research Program

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-15-1-0677 TITLE: PVAMU/XULA/BCM Summer Prostate Cancer Research Program PRINCIPAL INVESTIGATOR: Nancy L. Weigel...Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited...PVAMU/XULA/BCM Summer Prostate Cancer Research Program 5b. GRANT NUMBER W81XWH-15-1-0677 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Nancy L. Weigel

Federal Geothermal Research Program Update - Fiscal Year 2001

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laney, P.T.

2002-08-31

This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2001. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

Human Research Program Integrated Research Plan: December 20, 2007, Interim Baseline

NASA Technical Reports Server (NTRS)

2008-01-01

The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. This Integrated Research Plan (IRP) describes the program s research activities that are intended to address the needs of human space exploration and serve HRP customers. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration. The document serves several purposes for the Human Research Program: The IRP provides a means to assure that the most significant risks to human space explorers are being adequately mitigated and/or addressed, The IRP shows the relationship of research activities to expected outcomes and need dates, The IRP shows the interrelationships among research activities that may interact to produce products that are integrative or cross defined research disciplines, The IRP illustrates the non-deterministic nature of research and technology activities by showing expected decision points and potential follow-on activities, The IRP shows the assignments of responsibility within the program organization and, as practical, the intended solicitation approach, The IRP shows the intended use of research platforms such as the International Space Station, NASA Space Radiation Laboratory, and various space flight analogs. The IRP does not show all budgeted activities of the Human research program, as some of these are enabling functions, such as management, facilities and infrastructure

Qualilty, isotopes, and radiochemistry of water sampled from the Upper Moenkopi Village water-supply wells, Coconino County, Arizona

USGS Publications Warehouse

Carruth, Rob; Beisner, Kimberly; Smith, Greg

2013-01-01

The Hopi Tribe Water Resources Program has granted contracts for studies to evaluate water supply conditions for the Moenkopi villages in Coconino County, Arizona. The Moenkopi villages include Upper Moenkopi Village and the village of Lower Moencopi, both on the Hopi Indian Reservation south of the Navajo community of Tuba City. These investigations have determined that water supplies are limited and vulnerable to several potential sources of contamination, including the Tuba City Landfill and a former uranium processing facility known as the Rare Metals Mill. Studies are ongoing to determine if uranium and other metals in groundwater beneath the landfill are greater than regional groundwater concentrations. The source of water supply for the Upper Moenkopi Village is three public-supply wells. The wells are referred to as MSW-1, MSW-2, and MSW-3 and all three wells obtain water from the regionally extensive N aquifer. The N aquifer is the principal aquifer in this region of northern Arizona and consists of thick beds of sandstone between less permeable layers of siltstone and mudstone. The relatively fine-grained character of the N aquifer inhibits rapid movement of water and large yields to wells. In recent years, water levels have declined in the three public-supply wells, causing concern that the current water supply will not be able to accommodate peak demand and allow for residential and economic growth. Analyses of major ions, nutrients, selected trace metals, stable and radioactive isotopes, and radiochemistry were performed on the groundwater samples from the three public-supply wells to describe general water-quality conditions and groundwater ages in and immediately surrounding the Upper Moenkopi Village area. None of the water samples collected from the public-supply wells exceeded the U.S. Environmental Protection Agency primary drinking water standards. The ratios of the major dissolved ions from the samples collected from MSW-1 and MSW-2 indicate water with a major ion composition of calcium and sulfate. There is no significant vertical distribution of ion concentrations in the samples collected from the upper and lower portion of the water column within the two wells. The samples collected at MSW-3 are higher in sodium and lower in calcium than the samples collected from MSW-1 and MSW-2, and contain a similar sulfate-ion percentage. There is a vertical distribution of ion concentrations in the samples collected from the upper and lower portion of the water column in MSW-3. Groundwater samples from the three water-supply wells analyzed for oxygen-18 and deuterium stable isotopes plot on a local water line that is approximately parallel to the global meteoric water line. Tritium concentrations in samples from MSW-1 and MSW-3 were equal to or less than laboratory detection limits and were interpreted to contain no modern (post-1952) water. Tritium concentration in a sample from the top of the water column at MSW-2 was 0.41 tritium units, indicating that the composition is primarily pre-bomb (pre-1952) water, but may contain a small fraction of post-bomb modern water. The calculated carbon-14 ages of groundwater in MSW-1 and MSW-2, both completed about 140 feet into the Navajo Sandstone, are about 3,000 years before present. The calculated carbon-14 age of groundwater in MSW-3, completed about 240 feet into the Kayenta Formation-Navajo Sandstone transition zone is about 5,000 years before present in the upper portion of the water column and about 8,500 years before present in the lower portion of the water column. The gross alpha radioactivity of samples collected from the three water-supply wells ranged from 5.1 to 9.8 picocuries per liter-less than the U.S. Environmental Protection Agency primary drinking water standard of 15 picocuries per liter. The gross beta radioactivity of samples collected from the wells ranged from 0.9 to 2.8 picocuries per liter and are not considered elevated relative to the U.S. Environmental Protection Agency primary drinking water standard.

Family medicine research capacity building: five-weekend programs in Ontario.

PubMed

Rosser, Walter; Godwin, Marshall; Seguin, Rachelle

2010-03-01

Research is not perceived as an integral part of family practice by most family physicians working in community practices. OBJECTIVE OF THE PROGRAM To assist community-based practitioners in answering research questions that emerge from their practices in order for them to gain a better understanding of research and its value. The Ontario College of Family Physicians developed a program consisting of 5 sets of weekend workshops, each 2 months apart. Two pilots of the 5-weekend program occurred between 2000 and 2003. After the pilots, thirteen 5-weekend programs were held in 2 waves by 20 facilitators, who were trained in one of two 1-day seminars. This 5-weekend program, developed and tested in Ontario, stimulates community practitioners to learn how to answer research questions emerging from their practices. A 1-day seminar is adequate to train facilitators to successfully run these programs. Evaluations by both facilitators and program participants were very positive, with many participants stating that their clinical practices were improved as a result of the program. The program has been adapted for residency training, and it has already been used internationally.

NASA Hydrogen Research at Florida Universities, Program Year 2003

NASA Technical Reports Server (NTRS)

Block, David L.; Raissi, Ali

2006-01-01

This document presents the final report for the NASA Hydrogen Research at Florida Universities project for program year 2003. This multiyear hydrogen research program has positioned Florida to become a major player in future NASA space and space launch projects. The program is funded by grants from NASA Glenn Research Center with the objective of supporting NASA's hydrogen-related space, space launch and aeronautical research activities. The program conducts over 40 individual projects covering the areas of cryogenics, storage, production, sensors, fuel cells, power and education. At the agency side, this program is managed by NASA Glenn Research Center and at the university side, co-managed by FSEC and the University of Florida with research being conducted by FSEC and seven Florida universities: Florida International University, Florida State University, Florida A&M University, University of Central Florida, University of South Florida, University of West Florida and University of Florida. For detailed information, see the documents section of www.hydrogenresearch.org. This program has teamed these universities with the nation's premier space research center, NASA Glenn, and the nation's premier space launch facility, NASA Kennedy Space Center. It should be noted that the NASA Hydrogen Research at Florida Universities program has provided a shining example and a conduit for seven Florida universities within the SUS to work collaboratively to address a major problem of national interest, hydrogen energy and the future of energy supply in the U.S.

Program of Research in Flight Dynamics, The George Washington University at NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Murphy, Patrick C. (Technical Monitor); Klein, Vladislav

2005-01-01

The program objectives are fully defined in the original proposal entitled Program of Research in Flight Dynamics in GW at NASA Langley Research Center, which was originated March 20, 1975, and in the renewals of the research program from January 1, 2003 to September 30, 2005. The program in its present form includes three major topics: 1. the improvement of existing methods and development of new methods for wind tunnel and flight data analysis, 2. the application of these methods to wind tunnel and flight test data obtained from advanced airplanes, 3. the correlation of flight results with wind tunnel measurements, and theoretical predictions.

ECUT: Energy Conversion and Utilization Technologies program. Industry, university and research interest in the US Department of Energy ECUT biocatalysis research activity

NASA Technical Reports Server (NTRS)

Wilcox, R. E.

1983-01-01

The results of a Research Opportunity Notice (RON) disseminated by the Jet Propulsion Laboratory for the U.S. Department of Energy Conversion and Utilization Technologies (ECUT) Program's Biocatalysis Research Activity are presented. The RON was issued in late April of 1983 and solicited expressions of interest from petrochemical and chemical companies, bioengineering firms, biochemical engineering consultants, private research laboratories, and universities for participating in a federal research program to investigate potential applications of biotechnology in producing chemicals. The RON results indicate that broad interest exists within the nation's industry, universities, and research institutes for the Activity and its planned research and development program.

FTA multi-year research program plan (FY 2009 - FY 2013).

DOT National Transportation Integrated Search

2008-09-01

The Multi-Year Research Program Plan (Program Plan), prepared by the Federal Transit Administrations (FTA) Office of : Research, Demonstration, and Innovation (TRI), is part of FTAs strategic planning process. It provides descriptive : summarie...

Research peer exchange, 2014.

DOT National Transportation Integrated Search

2017-08-01

The WSDOT Research Peer Exchange was held in Olympia, Washington on May 13 and 14, 2014 and addressed Research Program and Project Management as described in the following paragraphs: Program Management There are numerous funding programs, standing c...

QUARTERLY TECHNICAL PROGRESS REPORT, JULY, AUGUST, SEPTEMBER 1967.

DTIC Science & Technology

Contents: Circuit research program; Hardware systems research; Computer system software research; Illinois pattern recognition computer: ILLIAC II... service , use, and program development; IBM 7094/1401 service , use, and program development; Problem specifications; General laboratory information.

Exploratory technology research program for electrochemical energy storage

NASA Astrophysics Data System (ADS)

Kinoshita, K.

1992-06-01

The U.S. Department of Energy's Office of Propulsion Systems provides support for an electrochemical energy storage program, that includes research and development (R&D) on advanced rechargeable batteries and fuel cells. A major goal of this program is to develop electrochemical power sources suitable for application in electric vehicles. The program centers on advanced systems that offer the potential for high performance and low life-cycle costs. The DOE Electrochemical Energy Storage Program is divided into two projects: the Electric Vehicle Advanced Battery Systems Development (EVABS) Program and the Exploratory Technology Research (ETR) Program. The EVABS Program management responsibility has been assigned to Sandia National Laboratory, and the Lawrence Berkeley Laboratory is responsible for management of the ETR Program. The EVABS and ETR Programs include an integrated matrix of R&D efforts designed to advance progress on several candidate electrochemical systems. The United States Advanced Battery Consortium (USABC), a tripartite undertaking between DOE, the U.S. automobile manufacturers and the Electric Power Research Institute (EPRI), was formed in 1991 to accelerate the development of advanced batteries for consumer EVs. The role of the ETR Program is to perform supporting research on the advanced battery systems under development by the USABC and EVABS Program, and to evaluate new systems with potentially superior performance, durability and/or cost characteristics. The specific goal of the ETR Program is to identify the most promising electrochemical technologies and transfer them to the USABC, the battery industry and/or the EVABS Program for further development and scaleup. This report summarizes the research, financial and management activities relevant to the ETR Program in FY 1991.

A study of the minority college programs at the NASA Johnson Space Center

NASA Technical Reports Server (NTRS)

Tryman, Mfanya Donald

1987-01-01

Research programs in science and engineering at predominantly black and white universities which assist in training and furthering the capabilities of minorities in the field, are examined. The Minority Graduate Researcher's Program and the Historically Black College and University Program were the focus of this research. The objectives included investigating the organizational structure and processes of the programs, how they are run, how they differ, defining particular administrative tasks for these programs, the collection of data related to these programs, and recommending ways in which these programs can be improved for greater efficiency and effectiveness through the Equal Opportunity Programs Office.

Protected Resident Research Time Does Not Increase the Quantity or Quality of Residency Program Research Publications: A Comparison of 3 Orthopedic Residencies.

PubMed

Krueger, Chad A; Hoffman, Jeffery D; Balazs, George C; Johnson, Anthony E; Potter, Benjamin K; Belmont, Philip J

The effect of dedicated resident research time in terms of residency program research productivity remains largely unknown. We hypothesize that the quantity and quality of a residency program's peer-reviewed publications (PRPs) increase proportionately with the amount of dedicated research time given to residents. Three residency programs (P1, P2, and P3) were examined. P1 has a mandatory research year for all residents between postgraduate years 3 and 4. P2 has an elective research year for 1 resident between postgraduate years 2 and 3. P3 has no dedicated research time for residents. All publications produced by residents and staff at each program from January 2007 through December were recorded from PUBMED. SCImago Journal Rankings were used as a proxy to measure research quality. There was no significant difference in the number of publications produced between the institutions on a per-staff (p = 0.27) and per-resident (p = 0.80) basis. There were no residents at P3 who graduated without at least 1 PRP, whereas there were 7 residents from P1 and 8 residents from P2 who graduated without a PRP. There were no significant differences between programs in terms of the SCImago Journal Ranking for the journals containing their publications (p = 0.135). Residency programs with dedicated research time did not produce significantly (p > 0.05) more, or higher quality, PRPs than residencies without dedicated research time. It may be that the quantity and quality of PRPs is related more to faculty engagement, research interest, and mentorship at individual programs rather than the number of residents given dedicated time to complete research. Level 3. Published by Elsevier Inc.

Human Research Program Integrated Research Plan. Revision A January 2009

NASA Technical Reports Server (NTRS)

2009-01-01

The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

7 CFR 1150.153 - Qualified State or regional dairy product promotion, research or nutrition education programs.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., research or nutrition education programs. 1150.153 Section 1150.153 Agriculture Regulations of the... § 1150.153 Qualified State or regional dairy product promotion, research or nutrition education programs... nutrition education program may apply to the Secretary for certification of qualification so that producers...

7 CFR 1150.153 - Qualified State or regional dairy product promotion, research or nutrition education programs.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., research or nutrition education programs. 1150.153 Section 1150.153 Agriculture Regulations of the... § 1150.153 Qualified State or regional dairy product promotion, research or nutrition education programs... nutrition education program may apply to the Secretary for certification of qualification so that producers...

77 FR 1785 - FTA Fiscal Year 2012 Apportionments, Allocations, and Program Information

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-11

... and Research Program Grants, dated September 1, 2008. For more information, contact Victor Austin... Fund of the United States Treasury, which are Administrative Expenses, the New Starts and Research... Planning Program (49 U.S.C. 5305(d)) B. State Planning and Research Program (49 U.S.C. 5305(e)) C...

Urologic Oncology Branch - Training - NCI/AFUD | Center for Cancer Research

Cancer.gov

Postdoctoral Research Training Program This program is designed to train Ph.D. postdoctoral scientists in the growing field of urologic oncology. This program offers fellows the opportunity to participate in a diverse training experience that includes clinical and laboratory research on several urologic malignancies. The program provides an opportunity for selected individuals

Research of the Rio Grande Ecosystem Management Program

Treesearch

Deborah M. Finch

2000-01-01

This paper describes the mission, objectives, and preliminary results of the Middle Rio Grande Ecosystem Management Research Program managed at the Rocky Mountain Research Station's Albuquerque laboratory. This program was initiated in 1994 to address growing pressures to effectively manage the limited resources of the middle Rio Grande Basin. The program is...

Evaluation of a Research Mentorship Program in Community Care

ERIC Educational Resources Information Center

Ploeg, Jenny; de Witt, Lorna; Hutchison, Brian; Hayward, Lynda; Grayson, Kim

2008-01-01

This article describes the results of a qualitative case study evaluating a research mentorship program in community care settings in Ontario, Canada. The purpose of the program was to build evaluation and research capacity among staff of community care agencies through a mentorship program. Data were collected through in-depth, semi-structured…

Environmental Quality Research and Development. A Review and Analysis of Federal Programs.

ERIC Educational Resources Information Center

Executive Office of the President, Washington, DC.

This is the first interagency report on Federal environmental quality research and development programs that presents program descriptions, levels of funding, and analyses. Undertaken at the request of the Federal Council for Science and Technology, the study may be useful in identifying environmental quality research and development programs in…

Program of Research in Flight Dynamics in the JIAFS, George Washington University at NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Klein, Vladislav

2002-01-01

The program objectives are fully defined in the original proposal entitled 'Program of Research in Flight Dynamics in GW at NASA Langley Research Center,' which was originated March 20, 1975, and in the renewals of the research program from December 1, 2000 to November 30, 2001. The program in its present form includes three major topics: 1) the improvement of existing methods and development of new methods for wind tunnel and flight test data analysis, 2) the application of these methods to wind tunnel and flight test data obtained from advanced airplanes, 3) the correlation of flight results with wind tunnel measurements, and theoretical predictions. The Principal Investigator of the program is Dr. Vladislav Klein. Three Graduate Research Scholar Assistants (K. G. Mas, M. M. Eissa and N. M. Szyba) also participated in the program. Specific developments in the program during the period Dec. 1, 2001 through Nov. 30, 2002 included: 1) Data analysis of highly swept delta wing aircraft from wind and water tunnel data, and 2) Aerodynamic characteristics of the radio control aircraft from flight test.

Situated Research Design and Methodological Choices in Formative Program Evaluation

ERIC Educational Resources Information Center

Supovitz, Jonathan

2013-01-01

Design-based implementation research offers the opportunity to rethink the relationships between intervention, research, and situation to better attune research and evaluation to the program development process. Using a heuristic called the intervention development curve, I describe the rough trajectory that programs typically follow as they…

INCREASING DIVERSITY IN ENVIRONMENTAL SCIENCE AND ENGINEERING: THE ORD RESEARCH APPRENTICESHIP PROGRAM FOR HIGH SCHOOL STUDENTS

EPA Science Inventory

The "Research Apprenticeship Program for High School Students" began in 1990 as a collaborative effort between EPA's Office of Research and Development in Research Triangle Park, NC and Shaw University, an Historically Black College/University (HBCU) in Raleigh, NC. The program a...

Undergraduate Research Experience in Ocean/Marine Science (URE-OMS) with African Student Component

DTIC Science & Technology

2011-01-01

The Undergraduate Research Experience in Ocean/Marine Science program supports active participation by underrepresented undergraduate students in remote sensing and Ocean/Marine Science research training activities. The program is based on a model for undergraduate research programs supported by the National Science Foundation . The

Evaluation of NSF's International Research Fellowship Program: Final Report

ERIC Educational Resources Information Center

Martinez, Alina; Epstein, Carter; Parsad, Amanda; Whittaker, Karla

2012-01-01

Among the National Science Foundation's (NSF) postdoctoral programs, the International Research Fellowship Program (IRFP) is unique in its emphasis on providing postdoctoral fellows with international research experiences. Established in 1992, IRFP provides financial support to postdoctoral scientists for a research experience abroad lasting…

78 FR 46597 - Agency Information Collection Activities: State Water Resources Research Institute Program Annual...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-01

... Activities: State Water Resources Research Institute Program Annual Application and Reporting AGENCY: U.S....gov . SUPPLEMENTARY INFORMATION: Title: State Water Resources Research Institute Program Annual.... Abstract The Water Resources Research Act of 1984, as amended (42 U.S.C. 10301 et seq.), authorizes a water...

How To Create an Independent Research Program.

ERIC Educational Resources Information Center

Krieger, Melanie Jacobs

This guide explains how to establish a research program within a school and how to get students involved in independent research projects and national research competitions. Chapter 1, "Selling the Program," examines benefits to the community, school, teachers, and students. Chapter 2, "Assessing Your Situation," discusses how independent research…

A Framework of Operating Models for Interdisciplinary Research Programs in Clinical Service Organizations

ERIC Educational Resources Information Center

King, Gillian; Currie, Melissa; Smith, Linda; Servais, Michelle; McDougall, Janette

2008-01-01

A framework of operating models for interdisciplinary research programs in clinical service organizations is presented, consisting of a "clinician-researcher" skill development model, a program evaluation model, a researcher-led knowledge generation model, and a knowledge conduit model. Together, these models comprise a tailored, collaborative…

78 FR 52997 - Connected Vehicle Research Program Public Meeting; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... DEPARTMENT OF TRANSPORTATION Connected Vehicle Research Program Public Meeting; Notice of Public... overview of the ITS JPO Connected Vehicle research program. The meeting will take place September 24 to 26... . The public meeting is the best opportunity to learn details about the Connected Vehicle research...

Participatory Research in an Arts Integration Professional Development Program

ERIC Educational Resources Information Center

Cawthon, Stephanie W.; Dawson, Kathryn M.; Judd-Glossy, Laura; Ihorn, Shasta

2012-01-01

Drama for Schools (DFS) is an arts integration professional development program rooted in critical pedagogy and constructivism that emphasizes partnerships between school districts and a major research university. As a part of the research initiative embedded in this professional development program, DFS began an Arts integration Research Teacher…

Program of Research for Forests and Associated Rangelands

Treesearch

Nelson S. Loftus; Joseph G. Massey; [Compilers

1978-01-01

This research plan for the Southern Region is a companion publication to the National Program of Research for Forests and Associated Rangelands. While the national program reflects both regional and national priorities, this plan provides details on forestry research matters concerning the South. For the reader's convenience, background information on development...

NASA/OAI Research Associates program

NASA Technical Reports Server (NTRS)

Keith, Theo G., Jr.

1994-01-01

The intent of this activity was the development of a cooperative program between the Ohio Aerospace Institute and the NASA Lewis Research Center with the objective of better preparing recent university graduates for careers in government aerospace research laboratories. The selected individuals were given the title of research associate. To accomplish the aims of this effort: (1) the research associates were introduced to the NASA Lewis Research Center and its mission/programs, (2) the research associates directly participated in NASA research and development programs, and (3) the research associates were given continuing educational opportunities in specialized areas. A number of individuals participated in this project during the discourse of this cooperative agreement. Attached are the research summaries of eight of the research associates. These reports give a very good picture of the research activities that were conducted by the associates.

Highlights of the Annual Congress of the European Association of Nuclear Medicine, Helsinki 2004, and a dash of horizon scanning.

PubMed

Ell, Peter J

2005-01-01

The Annual Congress of the European Association of Nuclear Medicine represents the major scientific and professional event in the field of nuclear medicine in Europe. Specialists from all allied professions meet to discuss the latest findings and discoveries. A very large industrial exhibition demonstrates the latest technological innovations and developments. This Highlights Lecture summarises the scientific and medical advances discussed at this important gathering. The lecture covers a significant proportion of the data presented and/or discussed in up-to-date reviews, and places some of the trends encountered in the context of the evolution of the field as a whole. There is much food for thought in most areas of nuclear medicine: advances in instrumentation and data processing, progress in radiochemistry and pharmacy, novel diagnostics and therapeutics, and new insights in known areas of clinical application such as neurology and psychiatry, cardiology, oncology, endocrine disorders, paediatrics, nephro-urology and musculoskeletal disorders. This Highlights Lecture is, however, only a brief resume of the vast amount of data discussed, which can be found in much greater detail in the Congress Proceedings, published as volume 31, supplement 2 of Eur J Nucl Med Mol Imaging in August 2004.

A Hypothesis on Biological Protection from Space Radiation Through the Use of New Therapeutic Gases as Medical Counter Measures

NASA Technical Reports Server (NTRS)

Schoenfeld, Michael P.; Ansari, Rafat R.; Nakao, Atsunori; Wink, David

2011-01-01

Exposure to astronauts could be a significant obstacle for long duration manned space exploration because of current uncertainties regarding the extent of biological effects. Furthermore, concepts for protective shielding also pose a technically challenging issue due to the nature of cosmic radiation and current mass and power constraints with modern exploration technology. As biological damage from exposure is associated with increased oxidative stress, it would be enabling to mitigate and/or prevent stress prior to the development of clinical symptoms and disease. This paper hypothesizes a "systems biology" approach in which a combination of chemical and biological mitigation techniques are used conjunctively. It proposes using new, therapeutic, medical gases as both chemical radioprotectors for radical scavenging and biological promoters for management of the body s response to exposure. From reviewing radiochemistry of water, biological effects of CO, H2, NO, and H2S gas, and mechanisms of radiation biology, it is concluded that this approach may have great therapeutic potential for exposure. Furthermore, it also appears to have potential for curtailing the pathogenesis of other diseases in which oxidative stress has been implicated including cardiovascular disease, cancer, chronic inflammatory disease, hypertension, ischemia/reperfusion injury, acute respiratory distress syndrome, Parkinson s and Alzheimer s disease, cataracts, and aging.

Spectral analysis of rare earth elements using laser-induced breakdown spectroscopy

NASA Astrophysics Data System (ADS)

Martin, Madhavi Z.; Fox, Robert V.; Miziolek, Andrzej W.; DeLucia, Frank C.; André, Nicolas

2015-06-01

There is growing interest in rapid analysis of rare earth elements (REEs) both due to the need to find new natural sources to satisfy increased demand in their use in various electronic devices, as well as the fact that they are used to estimate actinide masses for nuclear safeguards and nonproliferation. Laser-Induced Breakdown Spectroscopy (LIBS) appears to be a particularly well-suited spectroscopy-based technology to rapidly and accurately analyze the REEs in various matrices at low concentration levels (parts-per-million). Although LIBS spectra of REEs have been reported for a number of years, further work is still necessary in order to be able to quantify the concentrations of various REEs in realworld complex samples. LIBS offers advantages over conventional solution-based radiochemistry in terms of cost, analytical turnaround, waste generation, personnel dose, and contamination risk. Rare earth elements of commercial interest are found in the following three matrix groups: 1) raw ores and unrefined materials, 2) as components in refined products such as magnets, lighting phosphors, consumer electronics (which are mostly magnets and phosphors), catalysts, batteries, etc., and 3) waste/recyclable materials (aka e-waste). LIBS spectra for REEs such as Gd, Nd, and Sm found in rare earth magnets are presented.

A novel radiochemical approach to 1-(2'-deoxy-2'-[(18) F]fluoro-β-d-arabinofuranosyl)cytosine ((18) F-FAC).

PubMed

Meyer, Jan-Philip; Probst, Katrin C; Trist, Iuni M L; McGuigan, Christopher; Westwell, Andrew D

2014-09-01

(18) F-FAC (1-(2'-deoxy-2'-[(18) F]fluoro-β-D-arabinofuranosyl)-cytosine) is an important 2'-fluoro-nucleoside-based positron emission tomography (PET) tracer that has been used for in vivo prediction of response to the widely used cancer chemotherapy drug gemcitabine. Previously reported synthetic routes to (18) F-FAC have relied on early introduction of the (18) F radiolabel prior to attachment to protected cytosine base. Considering the (18) F radiochemical half-life (110 min) and the technical challenges of multi-step syntheses on PET radiochemistry modular systems, late-stage radiofluorination is preferred for reproducible and reliable radiosynthesis with in vivo applications. Herein, we report the first late-stage radiosynthesis of (18) F-FAC. Cytidine derivatives with leaving groups at the 2'-position are particularly prone to undergo anhydro side-product formation upon heating because of their electron density at the 2-carbonyl pyrimidone oxygen. Our rationally developed fluorination precursor showed an improved reactivity-to-stability ratio at elevated temperatures. (18) F-FAC was obtained in radiochemical yields of 4.3-5.5% (n = 8, decay-corrected from end of bombardment), with purities ≥98% and specific activities ≥63 GBq/µmol. The synthesis time was 168 min. Copyright © 2014 John Wiley & Sons, Ltd.

Spectral Analysis of Rare Earth Elements using Laser-Induced Breakdown Spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Madhavi Z; Fox, Dr. Richard V; Miziolek, Andrzej W

2015-01-01

There is growing interest in rapid analysis of rare earth elements (REEs) both due to the need to find new natural sources to satisfy increased demand in their use in various electronic devices, as well as the fact that they are used to estimate actinide masses for nuclear safeguards and nonproliferation. Laser-Induced Breakdown Spectroscopy (LIBS) appears to be a particularly well-suited spectroscopy-based technology to rapidly and accurately analyze the REEs in various matrices at low concentration levels (parts-per-million). Although LIBS spectra of REEs have been reported for a number of years, further work is still necessary in order to bemore » able to quantify the concentrations of various REEs in real-world complex samples. LIBS offers advantages over conventional solution-based radiochemistry in terms of cost, analytical turnaround, waste generation, personnel dose, and contamination risk. Rare earth elements of commercial interest are found in the following three matrix groups: 1) raw ores and unrefined materials, 2) as components in refined products such as magnets, lighting phosphors, consumer electronics (which are mostly magnets and phosphors), catalysts, batteries, etc., and 3) waste/recyclable materials (aka e-waste). LIBS spectra for REEs such as Gd, Nd, and Sm found in rare earth magnets are presented.« less

Spectral Analysis of Rare Earth Elements using Laser-Induced Breakdown Spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Madhavi Z; Fox, Dr. Richard V; Miziolek, Andrzej W

2015-01-01

There is growing interest in rapid analysis of rare earth elements (REEs) both due to the need to find new natural sources to satisfy increased demand in their use in various electronic devices, as well as the fact that they are used to estimate actinide masses for nuclear safeguards and nonproliferation. Laser-Induced Breakdown Spectroscopy (LIBS) appears to be a particularly well-suited spectroscopy-based technology to rapidly and accurately analyze the REEs in various matrices at low concentration levels (parts-per-million). Although LIBS spectra of REEs have been reported for a number of years, further work is still necessary in order to bemore » able to quantify the concentrations of various REEs in realworld complex samples. LIBS offers advantages over conventional solution-based radiochemistry in terms of cost, analytical turnaround, waste generation, personnel dose, and contamination risk. Rare earth elements of commercial interest are found in the following three matrix groups: 1) raw ores and unrefined materials, 2) as components in refined products such as magnets, lighting phosphors, consumer electronics (which are mostly magnets and phosphors), catalysts, batteries, etc., and 3) waste/recyclable materials (aka e-waste). LIBS spectra for REEs such as Gd, Nd, and Sm found in rare earth magnets are presented.« less

Spectral Analysis of Rare Earth Elements using Laser-Induced Breakdown Spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Madhavi Z. Martin; Robert V. Fox; Andrzej W. Miziolek

2001-05-01

There is growing interest in rapid analysis of rare earth elements (REEs) both due to the need to find new natural sources to satisfy increased demand in their use in various electronic devices, as well as the fact that they are used to estimate actinide masses for nuclear safeguards and nonproliferation. Laser-Induced Breakdown Spectroscopy (LIBS) appears to be a particularly well-suited spectroscopy-based technology to rapidly and accurately analyze the REEs in various matrices at low concentration levels (parts-per-million). Although LIBS spectra of REEs have been reported for a number of years, further work is still necessary in order to bemore » able to quantify the concentrations of various REEs in realworld complex samples. LIBS offers advantages over conventional solution-based radiochemistry in terms of cost, analytical turnaround, waste generation, personnel dose, and contamination risk. Rare earth elements of commercial interest are found in the following three matrix groups: 1) raw ores and unrefined materials, 2) as components in refined products such as magnets, lighting phosphors, consumer electronics (which are mostly magnets and phosphors), catalysts, batteries, etc., and 3) waste/recyclable materials (aka e-waste). LIBS spectra for REEs such as Gd, Nd, and Sm found in rare earth magnets are presented.« less

New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease

PubMed Central

Sogbein, Oyebola O.; Pelletier-Galarneau, Matthieu; Schindler, Thomas H.; Wei, Lihui; Wells, R. Glenn; Ruddy, Terrence D.

2014-01-01

Nuclear cardiology has experienced exponential growth within the past four decades with converging capacity to diagnose and influence management of a variety of cardiovascular diseases. Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m radiotracers or thallium-201 has dominated the field; however new hardware and software designs that optimize image quality with reduced radiation exposure are fuelling a resurgence of interest at the preclinical and clinical levels to expand beyond MPI. Other imaging modalities including positron emission tomography (PET) and magnetic resonance imaging (MRI) continue to emerge as powerful players with an expanded capacity to diagnose a variety of cardiac conditions. At the forefront of this resurgence is the development of novel target vectors based on an enhanced understanding of the underlying pathophysiological process in the subcellular domain. Molecular imaging with novel radiopharmaceuticals engineered to target a specific subcellular process has the capacity to improve diagnostic accuracy and deliver enhanced prognostic information to alter management. This paper, while not comprehensive, will review the recent advancements in radiotracer development for SPECT and PET MPI, autonomic dysfunction, apoptosis, atherosclerotic plaques, metabolism, and viability. The relevant radiochemistry and preclinical and clinical development in addition to molecular imaging with emerging modalities such as cardiac MRI and PET-MR will be discussed. PMID:24901002

Microgravity Research Results and Experiences from the NASA Mir Space Station Program

NASA Technical Reports Server (NTRS)

Schagheck, R. A.; Trach, B.

2000-01-01

The Microgravity Research Program Office (MRPO) participated aggressively in Phase I of the International Space Station Program using the Russian Mir Space Station. The Mir Station offered an otherwise unavailable opportunity to explore the advantages and challenges to long duration microgravity space research. Payloads with both NASA and commercial backing were included as well as cooperative research with the Canadian Space Agency (CSA). From this experience, much was learned about dealing with long duration on orbit science utilization and developing new working relationships with our Russian partner to promote efficient planning, operations, and integration to solve complexities associated with a multiple partner program. Microgravity participation in the NASA Mir Program began with the first joint NASA Mir flight to the Mir Space Station. The earliest participation setup acceleration measurement capabilities that were used throughout the Program. Research, conducted by all Microgravity science disciplines, continued on each subsequent increment for the entire three-year duration of the Program. The Phase I Program included the Microgravity participation of over 30 Fluids, Combustion, Materials, and Biotechnology Sciences and numerous commercially sponsored research payloads. In addition to the research gained from Microgravity investigations, long duration operation of facility hardware was tested. Microgravity facilities operated on Mir included the Space Acceleration Measurement System (SAMS), the Microgravity Glovebox (MGBX), the Biotechnology System (BTS) and the Canadian Space Agency sponsored Microgravity Isolation Mount (MIM). The Russian OPTIZONE Furnace was also incorporated into our material science research. All of these efforts yielded significant and useful scientific research data. This paper focuses on the microgravity research conducted onboard the Mir space station. It includes the Program preparation and planning necessary to support this type of cross increment research experience; the payloads which were flown; and summaries of significant microgravity science findings. Most importantly this paper highlights the various disciplines of microgravity research conducted during the International Space Station, Phase 1 Program onboard the Mir Station. A capsulation of significant research and the applicability of our findings are provided. In addition, a brief discussion of how future microgravity science gathering capabilities, hardware development and payload operations techniques have enhanced our ability to conduct long duration microgravity research.