Structured Hierarchical Ada Presentation Using Pictographs (SHARP) definition, Application and Automation

DTIC Science & Technology

1986-09-01

implement a computer program as a function of the Function Point Total. As shown in Table 9, the software product (referred to as SPQR ) establishes the...language being used. Source code statements are defined in SPQR as consisting of executable statements and data definitions. The factors used to calculate... SPQR is a trademark of Software Productivity Research, Inc, 233 TABLE 9 NUMBER OF COMPUTER PROGRAM SOURCE STATEMENTS PER FUNCTION POINT TOTAL

Effectiveness of a School-based Academic Asthma Health Education and Counseling Program on Fostering Acceptance of Asthma in Older School-age Students with Asthma

PubMed Central

Kintner, Eileen K.; Cook, Gwendolyn; Marti, C. Nathan; Gomes, Melissa; Meeder, Linda; Van Egeren, Laurie A.

2014-01-01

Purpose The purpose was to evaluate the effectiveness of the academic asthma education and counseling SHARP program on fostering psychosocial acceptance of asthma. Design and Methods This was a phase III, two-group, cluster randomized, single-blinded, longitudinal study. Students from grades 4 and 5 (N = 205) with asthma and their caregivers completed surveys at pre-intervention and at 1, 12, and 24 months post-intervention. Analysis involved multilevel modeling. Results All students demonstrated significant improvement in aspects of acceptance; students in SHARP demonstrated significant improvement in openness to sharing and connectedness with teachers over students in the control condition. Practice Implications The SHARP program offers a well-tested, effective program for psychosocial acceptance of asthma, which is welcomed by schools. PMID:25443593

Post Flight Analysis Of SHEFEX I: Shock Tunnel Testing And Related CFD Analysis

NASA Astrophysics Data System (ADS)

Schramm, Jan Martinez; Barth, Tarik; Wagner, Alexander; Hannemann, Klaus

2011-05-01

The SHarp Edge Flight EXperiment (SHEFEX) program of the German Aerospace Center (DLR) is primarily focused on the investigation of the potential to utilise improved shapes for space vehicles by considering sharp edges and facetted surfaces. One goal is to set up a sky based test facility to gain knowledge of the physics of hypersonic flow, complemented by numerical analysis and ground based testing. Further, the series of SHEFEX flight experiments is an excellent test bed for new technological concepts and flight instrumentation, and it is a source of motivation for young scientist and engineers providing an excellent school for future space-program engineers and managers. After the successful first SHEFEX flight in October 2005, a second flight is scheduled for September 2011 and additional flights are planned for 2015 ff. With the SHEFEX-I flight and the subsequent numerical and experimental post flight analysis, DLR could for the first time close the loop between the three major disciplines of aerothermodynamic research namely CFD, ground based testing and flight.

Electronic research and technology requirements for marine resources

NASA Technical Reports Server (NTRS)

Ewing, G. C.

1971-01-01

The Woods Hole air/space oceanographic program for 1969 is discussed. Studies included: (1) monitoring the sharp temperature boundary of the Gulf Stream by microwave and infrared observation, (2) spectrophotometry of the Gulf Stream and the adjacent continental slope and shelf water over Georges Bank, (3) interpretation of cloud and other meteorological data in terms of the effects of wind and sun on the upper ocean, (4) a sea state test plan, (5) systems research, and (6) ocean data recovery by aircraft and satellite.

Preparing the workforce for healthy aging programs: the Skills for Healthy Aging Resources and Programs (SHARP) model.

PubMed

Frank, Janet C; Altpeter, Mary; Damron-Rodriguez, JoAnn; Driggers, Joann; Lachenmayr, Susan; Manning, Colleen; Martinez, Dana M; Price, Rachel M; Robinson, Patricia

2014-10-01

Current public health and aging service agency personnel have little training in gerontology, and virtually no training in evidence-based health promotion and disease management programs for older adults. These programs are rapidly becoming the future of our community-based long-term care support system. The purpose of this project was to develop and test a model community college career technical education program, Skills for Healthy Aging Resources and Programs (SHARP), for undergraduate college students, current personnel in aging service and community organizations, and others interested in retraining. A multidisciplinary cross-sector team from disciplines of public health, sociology, gerontology and nursing developed four competency-based courses that focus on healthy aging, behavior change strategies, program management, an internship, and an option for leader training in the Chronic Disease Self-Management Program. To enhance implementation and fidelity, intensive faculty development training was provided to all instructors and community agency partners. Baseline and postprogram evaluation of competencies for faculty and students was conducted. Process evaluation for both groups focused on satisfaction with the curricula and suggestions for program improvement. SHARP has been piloted five times at two community colleges. Trainees (n = 113) were primarily community college students (n = 108) and current aging service personnel (n = 5). Statistically significant improvements in all competencies were found for both faculty and students. Process evaluation outcomes identified the needed logical and component adaptations to enhance the feasibility of program implementation, dissemination, and student satisfaction. The SHARP program provides a well-tested, evidence-based effective model for addressing workforce preparation in support of healthy aging service program expansion and delivery. © 2014 Society for Public Health Education.

The impact of sharps injuries on student nurses: a systematic review.

PubMed

Hambridge, Kevin; Nichols, Andrew; Endacott, Ruth

2016-10-27

The purpose of this review was to discover the impact of sharps injuries in the student nurse population. Much is known and reported about sharps injuries in registered nurses, but there has been a lack of published evidence regarding sharps injuries within the student nurse population. A systematic review of nursing, health and psychology databases was conducted. The limits set were publications between 1980 and 2014 in the English language. Studies were identified then, following a rigorous critical and quality appraisal with validated tools, were selected for the systematic review. A total of 40 articles met the inclusion criteria, reporting studies conducted in 18 countries. Psychological and physical impacts of sharps injuries in student nurses were reported, such as fear, anxiety and depression, although these impacts were not quantified using a validated instrument. The impact of sharps injuries can be severe, both psychological and physical. This systematic review shows that further research is needed into this, especially in under-researched areas such as the UK, to establish the impact of sharps injuries within this population. Further research would also aid the education and prevention of this harmful problem. The review also emphasises the psychological issues relating to sharps injuries, the impact these can have on individuals and the support and counselling that student nurses require after injury. These findings highlight the potential psychological issues that can result from sharps injuries in this population.

Fiscal 1982 Budget highlights R&D

NASA Astrophysics Data System (ADS)

Richman, Barbara T.

Geophysical research and development programs show growth beyond inflation in the $739.3 billion budget for fiscal 1982 that Jimmy Carter sent to Congress 5 days before completing his term. Included in the budget are provisions for increased support for the Ocean Margin Drilling Program and funds for an interagency Geological Applications Program, funds for an agriculture and resource surveys program that relies on remote sensing, and funds for the Venus Orbiting Imaging Radar mission.Ronald Reagan is expected to make changes in the budget as early as late February, although in mid January the heads of the scientific agencies could not characterize possible changes. Some Washingtonians say sharp cuts are inevitable, with basic research a prime candidate. Others, however, contend that the Reagan administration's push for productivity and innovation could prevent severe carving. Eos will track the FY 1982 budget changes through congressional approval.

Estimating site occupancy and detection probabilities for cooper's and sharp-shinned hawks in the Southern Sierra Nevada

Treesearch

Jennifer E. Carlson; Douglas D. Piirto; John J. Keane; Samantha J. Gill

2015-01-01

Long-term monitoring programs that can detect a population change over time can be useful for managers interested in assessing population trends in response to forest management activities for a particular species. Such long-term monitoring programs have been designed for the Northern Goshawk (Accipiter gentilis), but not for the more elusive Sharp...

Understanding sharps injuries in home healthcare: The Safe Home Care qualitative methods study to identify pathways for injury prevention.

PubMed

Markkanen, Pia; Galligan, Catherine; Laramie, Angela; Fisher, June; Sama, Susan; Quinn, Margaret

2015-04-11

Home healthcare is one of the fastest growing sectors in the United States. Percutaneous injuries from sharp medical devices (sharps) are a source of bloodborne pathogen infections among home healthcare workers and community members. Sharps use and disposal practices in the home are highly variable and there is no comprehensive analysis of the system of sharps procurement, use and disposal in home healthcare. This gap is a barrier to effective public health interventions. The objectives of this study were to i) identify the full range of pathways by which sharps enter and exit the home, stakeholders involved, and barriers for using sharps with injury prevention features; and ii) assess the leverage points for preventive interventions. This study employed qualitative research methods to develop two systems maps of the use of sharps and prevention of sharps injuries in home healthcare. Twenty-six in-depth interview sessions were conducted including home healthcare agency clinicians, public health practitioners, sharps device manufacturers, injury prevention advocates, pharmacists and others. Interview transcripts were audio-recorded and analyzed thematically using NVIVO qualitative research analysis software. Analysis of supporting archival material also was conducted. All findings guided development of the two maps. Sharps enter the home via multiple complex pathways involving home healthcare providers and home users. The providers reported using sharps with injury prevention features. However, home users' sharps seldom had injury prevention features and sharps were commonly re-used for convenience and cost-savings. Improperly discarded sharps present hazards to caregivers, waste handlers, and community members. The most effective intervention potential exists at the beginning of the sharps systems maps where interventions can eliminate or minimize sharps injuries, in particular with needleless treatment methods and sharps with injury prevention features. Manufacturers and insurance providers can improve safety with more affordable and accessible sharps with injury prevention features for home users. Sharps disposal campaigns, free-of-charge disposal containers, and convenient disposal options remain essential. Sharps injuries are preventable through public health actions that promote needleless treatment methods, sharps with injury prevention features, and safe disposal practices. Communication about hazards regarding sharps is needed for all home healthcare stakeholders.

Space Resources Utilization Roundtable

NASA Technical Reports Server (NTRS)

1999-01-01

This volume contains abstracts that have been accepted for presentation at the Space Resources Utilization Roundtable, October 27-29, 1999, in Golden, Colorado. The program committee consisted of M. B. Duke (Lunar and Planetary Institute), G. Baughman (Colorado School of Mines), D. Criswell (University of Houston), C. Graham (Canadian Mining Industry Research Organization), H. H. Schmitt (Apollo Astronaut), W. Sharp (Colorado School of Mines), L. Taylor (University of Tennessee), and a space manufacturing representative. Administration and publications support for this meeting were provided by the staff of the Publications and Program Services Department at the Lunar and Planetary Institute.

After an exposure to sharps or body fluids

MedlinePlus

... the area with soap and water. For a splash exposure to the nose, mouth, or skin, flush ... designing, implementing, and evaluating a sharps injury prevention program. www.cdc.gov/sharpssafety/pdf/sharpsworkbook_2008.pdf . ...

Aerothermodynamic Reentry Flight Experiments - EXPERT

DTIC Science & Technology

2005-10-01

IXV ( PRE-X – USV ) 3. IN FLIGHT RESEARCH VEHICLES e.g. - SHARP B1, B2 FLIGHTS, HYSHOT, X43, - IRDT, PAET, RAMC, FIRE - MIRKA, EXPRESS, SHEFEX ...PRE-X – USV ) 3. IN FLIGHT RESEARCH VEHICLES e.g. - SHARP B1, B2 FLIGHTS, HYSHOT, X43, - IRDT, PAET, RAMC, FIRE - MIRKA, EXPRESS, SHEFEX , SFYFE...RESEARCH VEHICLES e.g. - SHARP B1, B2 FLIGHTS, HYSHOT, X43, - IRDT, PAET, RAMC, FIRE - MIRKA, EXPRESS, SHEFEX , SFYFE - EXPERT Hypersonic Flight

Implementing AORN recommended practices for sharps safety.

PubMed

Ford, Donna A

2014-01-01

Prevention of percutaneous sharps injuries in perioperative settings remains a challenge. Occupational transmission of bloodborne pathogens, not only from patients to health care providers but also from health care providers to patients, is a significant concern. Legislation and position statements geared toward ensuring the safety of patients and health care workers have not resulted in significantly reduced sharps injuries in perioperative settings. Awareness and understanding of the types of percutaneous injuries that occur in perioperative settings is fundamental to developing an effective sharps injury prevention program. The AORN "Recommended practices for sharps safety" clearly delineates evidence-based recommendations for sharps injury prevention. Perioperative RNs can lead efforts to change practice for the safety of patients and perioperative team members by promoting the elimination of sharps hazards; the use of engineering, work practice, and administrative controls; and the proper use of personal protective equipment, including double gloving. Copyright © 2014 AORN, Inc. Published by Elsevier Inc. All rights reserved.

SHARP-B2: Flight Test Objectives, Project Implementation and Initial Results

NASA Technical Reports Server (NTRS)

Salute, Joan; Bull, Jeff; Rasky, Dan; Keese, David; Arnold, Jim (Technical Monitor)

2001-01-01

On September 28, 2000 the SHARP-B2 flight experiment was launched from Vandenberg Air Force Base, California. SHARP-B2 is the 2nd Ballistic flight test in the SHARP (Slender Hypervelocity Aerothermodynamic Research Probes) program which develops and tests new thermal protection materials and sharp body concepts. The flight tested Ultra-High Temperature Ceramics (UHTCs), which may radically change the design and performance of future aerospace vehicles. The new designs may overturn an age-old tenet of aerodynamics: that blunt-body aerospace vehicles, but not those with sharp leading edges, can survive the searing temperatures created as the vehicles tear through the atmosphere. Sharp leading edges offer numerous advantages over the blunt-body design currently in use. They could allow a space shuttle or crew return vehicle to maneuver in space more like an airplane and potentially allow astronauts to return to Earth from anywhere on orbit. They may allow improved astronaut safety by decreasing the risk of aborting into the ocean. They may reduce the electromagnetic interference that causes the communications blackouts that plague reentering blunt-body space vehicles. Reducing the amount of drag could lead to a reduction in propulsion requirements. Planetary probes could make use of sharp-body technology for aerobraking and to maximize their maneuvering capability. SHARP-B2 was a joint effort among NASA Ames, Sandia National Laboratories, the U.S. Air Force and the U.S. Army. It was funded by the Pathfinder Program at NASA's Marshall Space Flight Center. The SHARP-B2 payload was carried aboard a U.S. Air Force Minuteman III missile carrying a modified Mk 12A reentry vehicle (RV), which blasted off from Vandenberg Air Force Base near Lompoc, CA, at 3:01 a.m. PDT on Sept. 28. The RV was equipped with four 5. 1 inch-long strakes, or sharp leading edges. Each strake contained three UHTCs: ZrB2/SiC/C; ZrB2/SiC; and HfB2/SiC. Once it reached an altitude of about 400 nautical miles, the RV was released, returning through Earth's atmosphere at speeds exceeding Mach 22. One pair of strakes was designed to retract just before reaching temperatures high enough to cause the material to begin ablating. The other pair was designed to retract shortly after ablation began, at an expected temperature of nearly 5,100 degrees Fahrenheit. Sensors in the strakes measured how closely performance matched pre-flight calculations, and data was successfully collected throughout the 23-minute flight. A parachute was deployed (but not fully inflated) and the RV splashed down in a lagoon at the Kwajalein missile range in the Pacific Ocean. Within 3 hours radar track analysis showed ocean entry to be precisely at the latitude/longitude coordinates estimated during pre-flight simulation. An hour later a ship was deployed by the Army to recover the reentry vehicle, which was recovered in 165 feet of water, just 500 feet from its planned splash-down point. This is the first RV recovery in over a decade.

A Sharp methodology for VLSI layout

NASA Astrophysics Data System (ADS)

Bapat, Shekhar

1993-01-01

The layout problem for VLSI circuits is recognized as a very difficult problem and has been traditionally decomposed into the several seemingly independent sub-problems of placement, global routing, and detailed routing. Although this structure achieves a reduction in programming complexity, it is also typically accompanied by a reduction in solution quality. Most current placement research recognizes that the separation is artificial, and that the placement and routing problems should be solved ideally in tandem. We propose a new interconnection model, Sharp and an associated partitioning algorithm. The Sharp interconnection model uses a partitioning shape that roughly resembles the musical sharp 'number sign' and makes extensive use of pre-computed rectilinear Steiner trees. The model is designed to generate strategic routing information along with the partitioning results. Additionally, the Sharp model also generates estimates of the routing congestion. We also propose the Sharp layout heuristic that solves the layout problem in its entirety. The Sharp layout heuristic makes extensive use of the Sharp partitioning model. The use of precomputed Steiner tree forms enables the method to model accurately net characteristics. For example, the Steiner tree forms can model both the length of the net and more importantly its route. In fact, the tree forms are also appropriate for modeling the timing delays of nets. The Sharp heuristic works to minimize both the total layout area by minimizing total net length (thus reducing the total wiring area), and the congestion imbalances in the various channels (thus reducing the unused or wasted channel area). Our heuristic uses circuit element movements amongst the different partitioning blocks and selection of alternate minimal Steiner tree forms to achieve this goal. The objective function for the algorithm can be modified readily to include other important circuit constraints like propagation delays. The layout technique first computes a very high-level approximation of the layout solution (i.e., the positions of the circuit elements and the associated net routes). The approximate solution is alternately refined, objective function. The technique creates well defined sub-problems and offers intermediary steps that can be solved in parallel, as well as a parallel mechanism to merge the sub-problem solutions.

Sexual Health and Responsibility Program (SHARP): Preventing HIV, STIs, and Unplanned Pregnancies in the Navy and Marine Corps

PubMed Central

MacDonald, Michael R. (Bob)

2013-01-01

In 1999, the Navy and Marine Corps Public Health Center converted an HIV train-the-trainer program into a broader effort of preventing not just HIV, but also other sexually transmitted infections (STIs) and unplanned pregnancies. The premise for this broader approach was that a more comprehensive sexual health promotion message of STI, HIV, and unplanned pregnancy prevention is more likely to include at least one personally relevant concern for any given individual and is, therefore, more likely to be internalized and acted upon by the greatest number of individuals, and that risk reduction for any one of these consequences of sexual activity may reduce risk for all. This new effort was labeled the Sexual Health and Responsibility Program (SHARP). Within the Navy and Marine Corps, SHARP has become a focal and trusted source of sexual health promotion products, consultative services, and training, as well as a conduit for multidisciplinary collaboration and coordination. The existence of this central sexual health program normalizes integrated and comprehensive sexual health messages, enables efficiencies, promotes program and policy uniformity, and provides a forum for cross-organizational collaboration and continuous improvement. PMID:23450888

Female Staff Members in the Fabrication Shop

NASA Image and Video Library

1944-06-21

The loss of male NACA employees to the war effort and the military’s increased demand for expedited aeronautical research results resulted in a sharp demand for increased staffing in the early 1940s. The Aircraft Engine Research Laboratory (AERL) undertook an extensive recruiting effort to remedy the situation. Current employees were asked to bring in friends and family members, including women. The number of women employed at the AERL nearly doubled to 412 between 1943 and 1944. In May 1944 Director Raymond Sharp initiated a program to train women as machine operators, electricians, instrumentation engineers, and other technical positions. The move coincided with the lab’s implementation of a third shift to meet the military’s demands for improved aircraft performance. There was also a modest, but important, number of female engineers and chemists, as well as large group employed in more traditional positions such as data analysts, editors, and clerks. The integration of women in the research process was critical. Researchers developed a test and submitted plans to the Drafting Section to be converted into blueprints. In some instances the Instrumentation Shop was asked to create instruments for the test. During the test, computers gathered and analyzed the data. The researcher then wrote the report which was reviewed by the Editorial Department and printed in the Duplication Unit. All of these tasks were generally performed by female employees.

PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP, VOLUME 77, RBRC SCIENTIFIC REVIEW COMMITTEE MEETING, OCTOBER 10-12, 2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

SAMIOS, N.P.

The eighth evaluation of the RIKEN BNL Research Center (RBRC) took place on October 10-12, 2005, at Brookhaven National Laboratory. The members of the Scientific Review Committee (SRC) were Dr. Jean-Paul Blaizot, Professor Makoto Kobayashi, Dr. Akira Masaike, Professor Charles Young Prescott (Chair), Professor Stephen Sharpe (absent), and Professor Jack Sandweiss. We are grateful to Professor Akira Ukawa who was appointed to the SRC to cover Professor Sharpe's area of expertise. In addition to reviewing this year's program, the committee, augmented by Professor Kozi Nakai, evaluated the RBRC proposal for a five-year extension of the RIKEN BNL Collaboration MOU beyondmore » 2007. Dr. Koji Kaya, Director of the Discovery Research Institute, RIKEN, Japan, presided over the session on the extension proposal. In order to illustrate the breadth and scope of the RBRC program, each member of the Center made a presentation on higher research efforts. In addition, a special session was held in connection with the RBRC QCDSP and QCDOC supercomputers. Professor Norman H. Christ, a collaborator from Columbia University, gave a presentation on the progress and status of the project, and Professor Frithjof Karsch of BNL presented the first physics results from QCDOC. Although the main purpose of this review is a report to RIKEN Management (Dr. Ryoji Noyori, RIKEN President) on the health, scientific value, management and future prospects of the Center, the RBRC management felt that a compendium of the scientific presentations are of sufficient quality and interest that they warrant a wider distribution. Therefore we have made this compilation and present it to the community for its information and enlightenment.« less

National Dam Inspection Program. Lake Catalpa Dam (NDS-ID Number PA-560), (DER-ID Number 40-57) Susquehanna River Basin, Falls Creek, Luzerne County, Pennsylvania. Phase I Inspection Report,

DTIC Science & Technology

1980-09-01

Ogee spillway crest 1269.5 Sharp crest weir (rigid fish screen) 1271.5 N Upstream invert of spillway 1265.4 Downstream invert of spillway 1260.9 Maximum...Sluice gate Access Valve house upstream Regulating facilities Sluice gate i. Spillway. Type Concrete ogee to sharp crested weir Length 26 feet Ogee... crest elevation 1269.5 Sharp crest weir (rigid fish screen) 1271.5 Upstream channel Lake Downstream channel Reinforced concrete channel for

Traj_opt User's Guide

NASA Technical Reports Server (NTRS)

Saunders, David A.

2005-01-01

Trajectory optimization program Traj_opt was developed at Ames Research Center to help assess the potential benefits of ultrahigh temperature ceramic materials applied to reusable space vehicles with sharp noses and wing leading edges. Traj_opt loosely couples the Ames three-degrees-of-freedom trajectory package Traj (see NASA-TM-2004-212847) with the SNOPT optimization package (Stanford University Technical Report SOL 98-1). Traj_opt version January 22, 2003 is covered by this user guide. The program has been applied extensively to entry and ascent abort trajectory calculations for sharp and blunt crew transfer vehicles. The main optimization variables are control points for the angle of attack and bank angle time histories. No propulsion options are provided, but numerous objective functions may be specified and the nonlinear constraints implemented include a distributed surface heating constraint capability. Aero-capture calculations are also treated with an option to minimize orbital eccentricity at apoapsis. Traj_opt runs efficiently on a single processor, using forward or central differences for the gradient calculations. Results may be displayed conveniently with Gnuplot scripts. Control files recommended for five standard reentry and ascent abort trajectories are included along with detailed descriptions of the inputs and outputs.

Automated Consultation for the Diagnosis of Interplanetary Telecommunications

NASA Technical Reports Server (NTRS)

Quan, A. G.; Schwuttke, U. M.; Herstein, J. S.; Spagnuolo, J. S.; Burleigh, S.

1995-01-01

SHARP (Spacecraft Health Automated Reasoning Program) is a knowledge-based system for the diagnosis of problems in NASA's Deep Space Network (DSN) telecommunications system. This system provides the means of communication between a spacecraft and operations personnel at Jet Propulsion Laboratory. SHARP analyzes problems that occur in both the on-board spacecraft telecom subsystem, and the DSN.

Implementing a sharps injury reduction program at a charity hospital in India.

PubMed

Gramling, Joshua J; Nachreiner, Nancy

2013-08-01

Health care workers in India are at high risk of developing bloodborne infections from needlestick injuries. Indian hospitals often do not have the resources to invest in safety devices and protective equipment to decrease this risk. In collaboration with hospital staff, the primary author implemented a sharps injury prevention and biomedical waste program at an urban 60-bed charity hospital in northern India. The program aligned with hospital organizational objectives and was designed to be low-cost and sustainable. Occupational health nurses working in international settings or with international workers should be aware of employee and employer knowledge and commitment to occupational health and safety. Copyright 2013, SLACK Incorporated.

Behavior of healthcare workers after injuries from sharp instruments.

PubMed

Adib-Hajbaghery, Mohsen; Lotfi, Mohammad Sajjad

2013-09-01

Injuries with sharps are common occupational hazards for healthcare workers. Such injuries predispose the staff to dangerous infections such as hepatitis B, C and HIV. The present study was conducted to investigate the behaviors of healthcare workers in Kashan healthcare centers after needle sticks and injuries with sharps in 2012. A cross-sectional study was conducted on 298 healthcare workers of medical centers governed by Kashan University of Medical Sciences. A questionnaire was used in this study. The first part included questions about demographic characteristics. The second part of the questionnaire consisted of 16 items related to the sharp instrument injuries. For data analysis, descriptive and analytical statistics (chi-square, ANOVA and Pearson correlation coefficient) SPSS version 16.0 software was used. From a total of 298 healthcare workers, 114 (38.3%) had a history of injury from needles and sharp instruments in the last six months. Most needle stick and sharp instrument injuries had occurred among the operating room nurses and midwifes; 32.5% of injuries from sharp instruments occurred in the morning shift. Needles were responsible for 46.5% of injuries. The most common actions taken after needle stick injuries were compression (27.2%) and washing the area with soap and water (15.8%). Only 44.6% of the injured personnel pursued follow-up measures after a needle stick or sharp instrument injury. More than a half of the healthcare workers with needle stick or sharp instrument injury had refused follow-up for various reasons. The authorities should implement education programs along with protocols to be implemented after needle stick injuries or sharps.

UHTC Research at NASA Ames

NASA Technical Reports Server (NTRS)

Johnson, Sylvia M.

2011-01-01

For enhanced aerodynamic performance. Materials for sharp leading edges can be reusable but need different properties because of geometry and very high temperatures. Require materials with significantly higher temperature capabilities, but for short duration. Current shuttle RCC leading edge materials: T approx. 1650 C. Materials for vehicles with sharp leading edges: T>2000 C. >% Figure depicts: High Temperature at Tip and Steep Temperature Gradient. Passive cooling is simplest option to manage the intense heating on sharp leading edges.

Stories from the Sharp End: Case Studies in Safety Improvement

PubMed Central

McCarthy, Douglas; Blumenthal, David

2006-01-01

Motivated by pressure and a wish to improve, health care organizations are implementing programs to improve patient safety. This article describes six natural experiments in health care safety that show where the safety field is heading and opportunities for and barriers to improvement. All these programs identified organizational culture change as critical to making patients safer, differing chiefly in their methods of creating a patient safety culture. Their goal is a safety culture that promotes continuing innovation and improvement, transcending whatever particular safety methodology is used. Policymakers could help stimulate a culture of safety by linking regulatory goals to safety culture expectations, sponsoring voluntary learning collaborations, rewarding safety improvements, better using publicly reported data, encouraging consumer involvement, and supporting research and education. PMID:16529572

A Model for Postdoctoral Education That Promotes Minority and Majority Success in the Biomedical Sciences

PubMed Central

Eisen, Arri; Eaton, Douglas C.

2017-01-01

How does the United States maintain the highest-quality research and teaching in its professional science workforce and ensure that those in this workforce are effectively trained and representative of national demographics? In the pathway to science careers, the postdoctoral stage is formative, providing the experiences that define the independent work of one’s first faculty position. It is also a stage in which underrepresented minorities (URMs) disproportionately lose interest in pursuing academic careers in science and, models suggest, a point at which interventions to increase proportions of URMs in such careers could be most effective. We present a mixed-methods, case study analysis from 17 years of the Fellowships in Research and Science Teaching (FIRST) postdoctoral program, to our knowledge the largest and longest continuously running science postdoctoral program in the United States. We demonstrate that FIRST fellows, in sharp contrast to postdocs overall, are inclusive of URMs (50% African American; 70% women) and as or more successful in their fellowships and beyond as a comparison group (measured by publication rate, attainment of employment in academic science careers, and eventual research grant support). Analysis of alumni surveys and focus group discussions reveals that FIRST fellows place highest value on the cohort-driven community and the developmental teaching and research training the program provides. PMID:29196426

The Next Generation of Ground Operations Command and Control; Scripting in C Sharp and Visual Basic

NASA Technical Reports Server (NTRS)

Ritter, George; Pedoto, Ramon

2010-01-01

This slide presentation reviews the use of scripting languages in Ground Operations Command and Control. It describes the use of scripting languages in a historical context, the advantages and disadvantages of scripts. It describes the Enhanced and Redesigned Scripting (ERS) language, that was designed to combine the features of a scripting language and the graphical and IDE richness of a programming language with the utility of scripting languages. ERS uses the Microsoft Visual Studio programming environment and offers custom controls that enable an ERS developer to extend the Visual Basic and C sharp language interface with the Payload Operations Integration Center (POIC) telemetry and command system.

Overview of the SHARP campaign: Motivation, design, and major outcomes

NASA Astrophysics Data System (ADS)

Olaguer, Eduardo P.; Kolb, Charles E.; Lefer, Barry; Rappenglück, Bernhard; Zhang, Renyi; Pinto, Joseph P.

2014-03-01

The Study of Houston Atmospheric Radical Precursors (SHARP) was a field campaign developed by the Houston Advanced Research Center on behalf of the Texas Environmental Research Consortium. SHARP capitalized on previous research associated with the Second Texas Air Quality Study and the development of the State Implementation Plan (SIP) for the Houston-Galveston-Brazoria (HGB) ozone nonattainment area. These earlier studies pointed to an apparent deficit in ozone production in the SIP attainment demonstration model despite the enhancement of simulated emissions of highly reactive volatile organic compounds in accordance with the findings of the original Texas Air Quality Study in 2000. The scientific hypothesis underlying the SHARP campaign was that there are significant undercounted primary and secondary sources of the radical precursors, formaldehyde, and nitrous acid, in both heavily industrialized and more typical urban areas of Houston. These sources, if properly taken into account, could increase the production of ozone in the SIP model and the simulated efficacy of control strategies designed to bring the HGB area into ozone attainment. This overview summarizes the precursor studies and motivations behind SHARP, as well as the overall experimental design and major findings of the 2009 field campaign. These findings include significant combustion sources of formaldehyde at levels greater than accounted for in current point source emission inventories; the underestimation of formaldehyde and nitrous acid emissions, as well as CO/NOx and NO2/NOx ratios, by mobile source models; and the enhancement of nitrous acid by atmospheric organic aerosol.

Enhancements to the SHARP Build System and NEK5000 Coupling

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCaskey, Alex; Bennett, Andrew R.; Billings, Jay Jay

The SHARP project for the Department of Energy's Nuclear Energy Advanced Modeling and Simulation (NEAMS) program provides a multiphysics framework for coupled simulations of advanced nuclear reactor designs. It provides an overall coupling environment that utilizes custom interfaces to couple existing physics codes through a common spatial decomposition and unique solution transfer component. As of this writing, SHARP couples neutronics, thermal hydraulics, and structural mechanics using PROTEUS, Nek5000, and Diablo respectively. This report details two primary SHARP improvements regarding the Nek5000 and Diablo individual physics codes: (1) an improved Nek5000 coupling interface that lets SHARP achieve a vast increase inmore » overall solution accuracy by manipulating the structure of the internal Nek5000 spatial mesh, and (2) the capability to seamlessly couple structural mechanics calculations into the framework through improvements to the SHARP build system. The Nek5000 coupling interface now uses a barycentric Lagrange interpolation method that takes the vertex-based power and density computed from the PROTEUS neutronics solver and maps it to the user-specified, general-order Nek5000 spectral element mesh. Before this work, SHARP handled this vertex-based solution transfer in an averaging-based manner. SHARP users can now achieve higher levels of accuracy by specifying any arbitrary Nek5000 spectral mesh order. This improvement takes the average percentage error between the PROTEUS power solution and the Nek5000 interpolated result down drastically from over 23 % to just above 2 %, and maintains the correct power profile. We have integrated Diablo into the SHARP build system to facilitate the future coupling of structural mechanics calculations into SHARP. Previously, simulations involving Diablo were done in an iterative manner, requiring a large amount manual work, and left only as a task for advanced users. This report will detail a new Diablo build system that was implemented using GNU Autotools, mirroring much of the current SHARP build system, and easing the use of structural mechanics calculations for end-users of the SHARP multiphysics framework. It lets users easily build and use Diablo as a stand-alone simulation, as well as fully couple with the other SHARP physics modules. The top-level SHARP build system was modified to allow Diablo to hook in directly. New dependency handlers were implemented to let SHARP users easily build the framework with these new simulation capabilities. The remainder of this report will describe this work in full, with a detailed discussion of the overall design philosophy of SHARP, the new solution interpolation method introduced, and the Diablo integration work. We will conclude with a discussion of possible future SHARP improvements that will serve to increase solution accuracy and framework capability.« less

A report on SHARP (Spacecraft Health Automated Reasoning Prototype) and the Voyager Neptune encounter

NASA Technical Reports Server (NTRS)

Martin, R. G. (Editor); Atkinson, D. J.; James, M. L.; Lawson, D. L.; Porta, H. J.

1990-01-01

The development and application of the Spacecraft Health Automated Reasoning Prototype (SHARP) for the operations of the telecommunications systems and link analysis functions in Voyager mission operations are presented. An overview is provided of the design and functional description of the SHARP system as it was applied to Voyager. Some of the current problems and motivations for automation in real-time mission operations are discussed, as are the specific solutions that SHARP provides. The application of SHARP to Voyager telecommunications had the goal of being a proof-of-capability demonstration of artificial intelligence as applied to the problem of real-time monitoring functions in planetary mission operations. AS part of achieving this central goal, the SHARP application effort was also required to address the issue of the design of an appropriate software system architecture for a ground-based, highly automated spacecraft monitoring system for mission operations, including methods for: (1) embedding a knowledge-based expert system for fault detection, isolation, and recovery within this architecture; (2) acquiring, managing, and fusing the multiple sources of information used by operations personnel; and (3) providing information-rich displays to human operators who need to exercise the capabilities of the automated system. In this regard, SHARP has provided an excellent example of how advanced artificial intelligence techniques can be smoothly integrated with a variety of conventionally programmed software modules, as well as guidance and solutions for many questions about automation in mission operations.

The Sharpness of Blades Used in Dermatologic Surgery.

PubMed

Awadalla, Farah; Hexsel, Camile; Goldberg, Leonard H

2016-01-01

There are numerous blades available for use in dermatologic procedures. There are different advantages that are inhere.nt to different blades due to their shape and size. One aspect of the blade that is instrumental to its performance, but is not objectively defined, is sharpness. This information could be useful when choosing a blade for a particular procedure. This study aims to objectively define the sharpness of blades used in dermatologic surgery. The Sharpness Tester (Cutlery and Allied Trades Research Association, Sheffield, UK) was used to test the force in Newtons a blade requires to cut through a silicone cylinder. New blades were used to determine a standard for the sharpness of new blades. Blades used for surgery were tested to determine the sharpness after use. The sharpest blade is the double-edged razor blade (0.395 N) followed by the dermablade (0.46 N), plastic handled #15 (0.541 N), #15c (0.575 N), #10 (0.647 N), and the #15 blade (0.664 N). The sharpness of a blade is an important factor in its ability to perform a task and should be taken into account when choosing a particular blade for a particular procedure.

Preparing the Workforce for Healthy Aging Programs: The Skills for Healthy Aging Resources and Programs (SHARP) Model

ERIC Educational Resources Information Center

Frank, Janet C.; Altpeter, Mary; Damron-Rodriguez, JoAnn; Driggers, Joann; Lachenmayr, Susan; Manning, Colleen; Martinez, Dana M.; Price, Rachel M.; Robinson, Patricia

2014-01-01

Current public health and aging service agency personnel have little training in gerontology, and virtually no training in evidence-based health promotion and disease management programs for older adults. These programs are rapidly becoming the future of our community-based long-term care support system. The purpose of this project was to develop…

Understanding the Hospital Sharps Injury Reporting Pathway

PubMed Central

Boden, Leslie I.; Petrofsky, Yolanta V.; Hopcia, Karen; Wagner, Gregory R.; Hashimoto, Dean

2016-01-01

Introduction Patient-care workers are frequently exposed to sharps injuries, which can involve the risk of serious illness. Underreporting of these injuries can compromise prevention efforts. Materials and Methods We linked survey responses of 1572 non-physician patient-care workers with the Occupational Health Services (OHS) database at two academic hospitals. We determined whether survey respondents who said they had sharps injuries indicated that they had reported them and whether reported injuries were recorded in the OHS database. Results Respondents said that they reported 62 of 78 sharps injuries occurring over a 12-month period. Only 28 appeared in the OHS data. Safety practices were positively associated with respondents’ saying they reported sharps injuries but not with whether reported injuries appeared in the OHS data. Conclusions Administrators should consider creating reporting mechanisms that are simpler and more direct. Administrators and researchers should attempt to understand how incidents might be lost before they are recorded. PMID:25308763

A NASA SHARP Mentoring Experience Utilizing GP-B

NASA Technical Reports Server (NTRS)

Estes, Howard

2004-01-01

The goal of this program is to increase the participation and success rates of students who are traditionally underrepresented in science, mathematics, technology , and geography. Students are selected based on aptitude and oi nterests. It is a NASA sponsored, 8 week program.

Ethical practice in internet research involving vulnerable people: lessons from a self-harm discussion forum study (SharpTalk).

PubMed

Sharkey, Siobhan; Jones, Ray; Smithson, Janet; Hewis, Elaine; Emmens, Tobit; Ford, Tamsin; Owens, Christabel

2011-12-01

The internet is widely used for health information and support, often by vulnerable people. Internet-based research raises both familiar and new ethical problems for researchers and ethics committees. While guidelines for internet-based research are available, it is unclear to what extent ethics committees use these. Experience of gaining research ethics approval for a UK study (SharpTalk), involving internet-based discussion groups with young people who self-harm and health professionals is described. During ethical review, unsurprisingly, concerns were raised about the vulnerability of potential participants. These were dominated by the issue of anonymity, which also affected participant safety and consent. These ethical problems are discussed, and our solutions, which included: participant usernames specific to the study, a closed website, private messaging facilities, a direct contact email to researchers, information about forum rules displayed on the website, a 'report' button for participants, links to online support, and a discussion room for forum moderators. This experience with SharpTalk suggests that an approach to ethics, which recognises the relational aspects of research with vulnerable people, is particularly useful for internet-based health research. The solutions presented here can act as guidance for researchers developing proposals and for ethics committees reviewing them.

International organisation of ocean programs: Making a virtue of necessity

NASA Technical Reports Server (NTRS)

Mcewan, Angus

1992-01-01

When faced with the needs of climate prediction, a sharp contrast is revealed between existing networks for the observation of the atmosphere and for the ocean. Even the largest and longest-serving ocean data networks were created for their value to a specific user (usually with a defence, fishing or other maritime purpose) and the major compilations of historical data have needed extensive scientific input to reconcile the differences and deficiencies of the various sources. Vast amounts of such data remain inaccessible or unusable. Observations for research purposes have been generally short lived and funded on the basis of single initiatives. Even major programs such as FGGE, TOGA and WOCE have been driven by the dedicated interest of a surprisingly small number of individuals, and have been funded from a wide variety of temporary allocations. Recognising the global scale of ocean observations needed for climate research, international cooperation and coordination is an unavoidable necessity, resulting in the creation of such bodies as the Committee for Climatic Changes and the Ocean (CCCO), with the tasks of: (1) defining the scientific elements of research and ocean observation which meet the needs of climate prediction and amelioration; (2) translating these elements into terms of programs, projects or requirements that can be understood and participated in by individual nations and marine agencies; and (3) the sponsorship of specialist groups to facilitate the definition of research programs, the implementation of cooperative international activity and the dissemination of results.

Health care transformation through collaboration on open-source informatics projects: integrating a medical applications platform, research data repository, and patient summarization.

PubMed

Klann, Jeffrey G; McCoy, Allison B; Wright, Adam; Wattanasin, Nich; Sittig, Dean F; Murphy, Shawn N

2013-05-30

The Strategic Health IT Advanced Research Projects (SHARP) program seeks to conquer well-understood challenges in medical informatics through breakthrough research. Two SHARP centers have found alignment in their methodological needs: (1) members of the National Center for Cognitive Informatics and Decision-making (NCCD) have developed knowledge bases to support problem-oriented summarizations of patient data, and (2) Substitutable Medical Apps, Reusable Technologies (SMART), which is a platform for reusable medical apps that can run on participating platforms connected to various electronic health records (EHR). Combining the work of these two centers will ensure wide dissemination of new methods for synthesized views of patient data. Informatics for Integrating Biology and the Bedside (i2b2) is an NIH-funded clinical research data repository platform in use at over 100 sites worldwide. By also working with a co-occurring initiative to SMART-enabling i2b2, we can confidently write one app that can be used extremely broadly. Our goal was to facilitate development of intuitive, problem-oriented views of the patient record using NCCD knowledge bases that would run in any EHR. To do this, we developed a collaboration between the two SHARPs and an NIH center, i2b2. First, we implemented collaborative tools to connect researchers at three institutions. Next, we developed a patient summarization app using the SMART platform and a previously validated NCCD problem-medication linkage knowledge base derived from the National Drug File-Reference Terminology (NDF-RT). Finally, to SMART-enable i2b2, we implemented two new Web service "cells" that expose the SMART application programming interface (API), and we made changes to the Web interface of i2b2 to host a "carousel" of SMART apps. We deployed our SMART-based, NDF-RT-derived patient summarization app in this SMART-i2b2 container. It displays a problem-oriented view of medications and presents a line-graph display of laboratory results. This summarization app can be run in any EHR environment that either supports SMART or runs SMART-enabled i2b2. This i2b2 "clinical bridge" demonstrates a pathway for reusable app development that does not require EHR vendors to immediately adopt the SMART API. Apps can be developed in SMART and run by clinicians in the i2b2 repository, reusing clinical data extracted from EHRs. This may encourage the adoption of SMART by supporting SMART app development until EHRs adopt the platform. It also allows a new variety of clinical SMART apps, fueled by the broad aggregation of data types available in research repositories. The app (including its knowledge base) and SMART-i2b2 are open-source and freely available for download.

Sustained Assessment, Version n.0: Efforts of the Sustained Assessment Working Group

NASA Astrophysics Data System (ADS)

Leidner, A. K.; Barrie, D.; Reidmiller, D.; Lewis, K.

2017-12-01

In parallel with the development of the Third National Climate Assessment (NCA3, 2014), the U.S. Global Change Research Program, with inputs from the non-federal climate assessment community, sought to define a sustained assessment process. Although many elements of a sustained process were initiated during NCA3 and continued into the NCA4 era, progress is still needed. To address this need, a new Federal Interagency working group of the U.S. Global Change Research Program (USGCRP) - the Sustained Assessment Working Group (SAWG) - was established in summer 2017. Its formation was motivated by a desire to avoid the sharp peaks in effort that accompanies production of the Congressionally-mandated quadrennial Assessment, followed by the dips in activity after a report is completed. With a goal of distributing and flattening effort, and providing a way to sustain engagement and better connect assessment-relevant activities, the SAWG is using inputs from the thirteen USGCRP agencies, federal advisory groups, and other sources to make recommendations to the agencies of the U.S. Global Change Research Program. The group will work with the agencies to implement these recommendations and monitor progress toward creating a sustained - and sustainable - assessment process. This presentation will detail the efforts and goals of SAWG and report on recent milestones.

SHARK: Flight Results of an UHTC-Based Nose Related to USV Hot Structures

NASA Astrophysics Data System (ADS)

Gardi, R.; Del Vecchio, A.; Russo, G.; Marino, G.

2011-05-01

In the frame of USV program, CIRA is developing different projects aimed to develop new technologies for the future hypersonic vehicles. One of these technological projects is Sharp Hot Structures (SHS) and it is aimed to the realization of innovative thermo- structures, based on innovative material solution, able to sustain the heat loads generated during the hypersonic flight. Because the slender configuration of the USV program vehicles, SHS is focused on sharp geometries, like sharp leading edges and sharp nose cones. CIRA, for many years, is investigating the effectiveness of ultra high temperature ceramic materials (UHTC) by means of numerical simulations, ground testing in plasma torch and in SCIROCCO, the 70MW plasma wind tunnel (PWT) facility at CIRA. More recently CIRA is moving the experimentation in real flight environment, boarding UHTC components on the re-entering space capsules EXPERT and SHARK. The former is a European experimental test bed boarding a couple of UHTC fins, already qualified and integrated on the vehicle. SHARK is a 20kg capsule launched on March the 26th 2010 from Kiruna with the European sounding rocker Maxus-8. During the ascent parabola, the capsule was released and successfully executed its 15 minutes ballistic flight and then re-entered in the atmosphere from a 700km altitude. The capsule has been recovered on July the 1st and all data have been acquired. All the instrumentation worked nicely and the data acquisition continued even after the landing, confirming the robustness of the design.

The internet worm

NASA Technical Reports Server (NTRS)

Denning, Peter J.

1989-01-01

In November 1988 a worm program invaded several thousand UNIX-operated Sun workstations and VAX computers attached to the Research Internet, seriously disrupting service for several days but damaging no files. An analysis of the work's decompiled code revealed a battery of attacks by a knowledgeable insider, and demonstrated a number of security weaknesses. The attack occurred in an open network, and little can be inferred about the vulnerabilities of closed networks used for critical operations. The attack showed that passwork protection procedures need review and strengthening. It showed that sets of mutually trusting computers need to be carefully controlled. Sharp public reaction crystalized into a demand for user awareness and accountability in a networked world.

Some aspects of precise laser machining - Part 2: Experimental

NASA Astrophysics Data System (ADS)

Grabowski, Marcin; Wyszynski, Dominik; Ostrowski, Robert

2018-05-01

The paper describes the role of laser beam polarization on quality of laser beam machined cutting tool edge. In micromachining the preparation of the cutting tools in play a key role on dimensional accuracy, sharpness and the quality of the cutting edges. In order to assure quality and dimensional accuracy of the cutting tool edge it is necessary to apply laser polarization control. In the research diode pumped Nd:YAG 532nm pulse laser was applied. Laser beam polarization used in the research was linear (horizontal, vertical). The goal of the carried out research was to describe impact of laser beam polarization on efficiency of the cutting process and quality of machined parts (edge, surface) made of polycrystalline diamond (PCD) and cubic boron nitride (cBN). Application of precise cutting tool in micromachining has significant impact on the minimum uncut chip thickness and quality of the parts. The research was carried within the INNOLOT program funded by the National Centre for Research and Development.

Black carbon emission reduction strategies in healthcare industry for effective global climate change management.

PubMed

Raila, Emilia Mmbando; Anderson, David O

2017-04-01

Climate change remains one of the biggest threats to life on earth to date with black carbon (BC) emissions or smoke being the strongest cause after carbon dioxide (CO 2 ). Surprisingly, scientific evidence about black carbon emissions reduction in healthcare settings is sparse. This paper presents new research findings on the reduction of black carbon emissions from an observational study conducted at the UN Peacekeeping Operations (MINUSTAH) in Haiti in 2014. Researchers observed 20 incineration cycles, 30 minutes for each cycle of plastic and cardboard sharps healthcare waste (HCW) containers ranged from 3 to 14.6 kg. The primary aim was to determine if black carbon emissions from healthcare waste incineration can be lowered by mainstreaming the use of cardboard sharps healthcare waste containers instead of plastic sharps healthcare waste containers. Similarly, the study looks into whether burning temperature was associated with the smoke levels for each case or not. Independent samples t-tests demonstrated significantly lower black carbon emissions during the incineration of cardboard sharps containers (6.81 ± 4.79% smoke) than in plastic containers (17.77 ± 8.38% smoke); a statistically significant increase of 10.96% smoke (95% Confidence Interval ( CI) [4.4 to 17.5% smoke], p = 0.003). Correspondingly, lower bottom burner temperatures occurred during the incineration of cardboard sharps containers than in plastic (95% Cl [16 to 126°C], p = 0.014). Finally, we expect the application of the new quantitative evidence to form the basis for policy formulation, mainstream the use of cardboard sharps containers and opt for non-incineration disposal technologies as urgent steps for going green in healthcare waste management.

Spectrophotometer properties of vein blood plasma in UF-region patients with sharp surgical pathology of abdominal region organs

NASA Astrophysics Data System (ADS)

Guminestskij, S. G.; Polianski, I. J.; Motrich, A. V.; Grunchuk, F. W.

2006-05-01

It is set that there are two maximums in UF- region absorption of vein blood plasma of a man: at λ = 235 nm and at λ = 280 nm. It is shown that there are the substantial changes of values of the optical density D comparative with controls (for donors) exactly in a maximum at development of sharp surgical diseases of organs of abdominal region λ = 280 nm, in that time as maximum at λ = 235 nm in this plan is not informing. Resulted results of researches of dynamics of changes of optical properties of vein blood plasma in UF- region of patients with pathology of abdominal region organs in after operating period (sharp appendicitis, sharp pancreatitis, intestinal impassability and others like that), which can have the diagnostic value.

Rapid Growth of Psychology Programs in Turkey: Undergraduate Curriculum and Structural Challenges

ERIC Educational Resources Information Center

Sümer, Nebi

2016-01-01

Similar to the other developing countries, undergraduate psychology programs in Turkish universities have rapidly grown in the last two decades. Although this sharp increment signifies the need for psychologists, it has also caused a number of challenges for effective teaching of psychology. The department chairs (N = 42) were interviewed with an…

Geology of the Early Arikareean sharps formation on the Pine Ridge Indian Reservation and surrounding areas of South Dakota and Nebraska.

PubMed

McConnell, Thomas H; Dibenedetto, Joseph N

2012-01-01

Based on geologic mapping, measured sections, and lithologic correlations, the local features of the upper and lower type areas of the Early Arikareean (30.8-20.6 million years ago) Sharps Formation are revised and correlated. The Sharps Formation above the basal Rockyford Member is divided into two members of distinct lithotypes. The upper 233 feet of massive siltstones and sandy siltstones is named the Gooseneck Road Member. The middle member, 161 feet of eolian volcaniclastic siltstones with fluvially reworked volcaniclastic lenses and sandy siltstone sheets, is named the Wolff Camp Member. An ashey zone at the base of the Sharps Formation is described and defined as the Rockyford Ash Zone (RAZ) in the same stratigraphic position as the Nonpareil Ash Zone (NPAZ) in Nebraska. Widespread marker beds of fresh water limestones at 130 feet above the base of the Sharps Formation and a widespread reddish-brown clayey siltstone at 165 feet above the base of the Sharps Formation are described. The Brown Siltstone Beds of Nebraska are shown to be a southern correlative of the Wolff Camp Member and the Rockyford Member of the Sharps Formation. Early attempts to correlate strata in the Great Plains were slow in developing. Recognition of the implications of the paleomagnetic and lithologic correlations of this paper will provide an added datum assisting researchers in future biostratigraphic studies. Based on similar lithologies, the Sharps Formation, currently assigned to the Arikaree Group, should be reassigned to the White River Group.

Effectiveness of a School- and Community-based Academic Asthma Health Education Program on Use of Effective Asthma Self-care Behaviors in Older School-age Students

PubMed Central

Kintner, Eileen K.; Cook, Gwendolyn; Marti, C. Nathan; Allen, April; Stoddard, Debbie; Harmon, Phyllis; Gomes, Melissa; Meeder, Linda; Van Egeren, Laurie A.

2014-01-01

Purpose The purpose was to evaluate the effectiveness of SHARP, an academic asthma health education and counseling program, on fostering use of effective asthma self-care behaviors. Design and Methods This was a phase III, two-group, cluster randomized, single-blinded, longitudinal design guided the study. Caregivers of 205 fourth- and fifth-grade students completed the asthma health behaviors survey at pre-intervention and 1, 12, and 24 months post-intervention. Analysis involved multilevel modeling. Results All students demonstrated improvement in episode management, risk-reduction/prevention, and health promotion behaviors; SHARP students demonstrated increased improvement in episode management and risk-reduction/prevention behaviors. Practice Implications Working with schoolteachers, nurses can improve use of effective asthma self-care behaviors. PMID:25443867

NiCd battery electrodes

NASA Technical Reports Server (NTRS)

Holleck, G.; Turchan, M.; Hopkins, J.

1972-01-01

The objective of this research program was to develop and evaluate electrodes for a negative limited nickel-cadmium cell and to prove its feasibility. The program consisted of three phases: (1) the development of cadmium electrodes with high hydrogen overvoltage characteristics, (2) the testing of positive and negative plates, and (3) the fabrication and testing of complete negative limited NiCd cells. The following electrode structures were manufactured and their physical and electrochemical characteristics were evaluated: (1) silver sinter-based Cd electrodes, (2) Teflon-bonded Cd electrodes, (3) electrodeposited Cd sponge, and (4) Cd-sinter structures. All cadmium electrode structures showed a sharp increase in potential at the end of charge, with the advent of hydrogen evolution occurring at approximately -1.3 V versus Hg/HgO. The hydrogen advent potentials on pure cadmium structures were 50 to 70 mV more cathodic than those of their silver-containing counterparts.

Software Analyzes Complex Systems in Real Time

NASA Technical Reports Server (NTRS)

2008-01-01

Expert system software programs, also known as knowledge-based systems, are computer programs that emulate the knowledge and analytical skills of one or more human experts, related to a specific subject. SHINE (Spacecraft Health Inference Engine) is one such program, a software inference engine (expert system) designed by NASA for the purpose of monitoring, analyzing, and diagnosing both real-time and non-real-time systems. It was developed to meet many of the Agency s demanding and rigorous artificial intelligence goals for current and future needs. NASA developed the sophisticated and reusable software based on the experience and requirements of its Jet Propulsion Laboratory s (JPL) Artificial Intelligence Research Group in developing expert systems for space flight operations specifically, the diagnosis of spacecraft health. It was designed to be efficient enough to operate in demanding real time and in limited hardware environments, and to be utilized by non-expert systems applications written in conventional programming languages. The technology is currently used in several ongoing NASA applications, including the Mars Exploration Rovers and the Spacecraft Health Automatic Reasoning Pilot (SHARP) program for the diagnosis of telecommunication anomalies during the Neptune Voyager Encounter. It is also finding applications outside of the Space Agency.

Computer program for calculating supersonic flow on the windward side conical delta wings by the method of lines

NASA Technical Reports Server (NTRS)

Klunker, E. B.; South, J. C., Jr.; Davis, R. M.

1972-01-01

A user's manual is presented for a program that calculates the supersonic flow on the windward side of conical delta wings with shock attached at the sharp leading edge by the method of lines. The program also has a limited capability for computing the flow about circular and elliptic cones at incidence. It provides information including the shock shape, flow field, isentropic surface-flow properties, and force coefficients. A description of the program operation, a sample computation, and a FORTRAN 4 program listing are included.

Particle trajectory computer program for icing analysis of axisymmetric bodies

NASA Technical Reports Server (NTRS)

Frost, Walter; Chang, Ho-Pen; Kimble, Kenneth R.

1982-01-01

General aviation aircraft and helicopters exposed to an icing environment can accumulate ice resulting in a sharp increase in drag and reduction of maximum lift causing hazardous flight conditions. NASA Lewis Research Center (LeRC) is conducting a program to examine, with the aid of high-speed computer facilities, how the trajectories of particles contribute to the ice accumulation on airfoils and engine inlets. This study, as part of the NASA/LeRC research program, develops a computer program for the calculation of icing particle trajectories and impingement limits relative to axisymmetric bodies in the leeward-windward symmetry plane. The methodology employed in the current particle trajectory calculation is to integrate the governing equations of particle motion in a flow field computed by the Douglas axisymmetric potential flow program. The three-degrees-of-freedom (horizontal, vertical, and pitch) motion of the particle is considered. The particle is assumed to be acted upon by aerodynamic lift and drag forces, gravitational forces, and for nonspherical particles, aerodynamic moments. The particle momentum equation is integrated to determine the particle trajectory. Derivation of the governing equations and the method of their solution are described in Section 2.0. General features, as well as input/output instructions for the particle trajectory computer program, are described in Section 3.0. The details of the computer program are described in Section 4.0. Examples of the calculation of particle trajectories demonstrating application of the trajectory program to given axisymmetric inlet test cases are presented in Section 5.0. For the examples presented, the particles are treated as spherical water droplets. In Section 6.0, limitations of the program relative to excessive computer time and recommendations in this regard are discussed.

Financial Aid and Students' College Decisions: Evidence from the District of Columbia Tuition Assistance Grant Program

ERIC Educational Resources Information Center

Abraham, Katharine G.; Clark, Melissa A.

2006-01-01

The District of Columbia Tuition Assistance Grant Program (DCTAG), instituted in 1999, allows D.C. residents to attend public colleges and universities throughout the country at considerably lower in-state tuition rates. We use the sharp decline in the price of public colleges and universities faced by D.C. residents to estimate the effects of…

Photofragment slice imaging studies of pyrrole and the Xe…pyrrole cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rubio-Lago, L.; Zaouris, D.; Sakellariou, Y.

The photolysis of pyrrole has been studied in a molecular beam at wavelengths 250 nm, 240 nm and 193.3 nm, using 2 different carrier gases, He and Xe. A broad bimodal distribution of H atom fragment velocities has been observed at all wavelengths. Near threshold at both 240 and 250 nm, , sharp features have been observed in the fast part of the H-atom distribution. Under appropriate molecular beam conditions, these sharp features and the photolysis of pyrrole at both 240 and 250 nm disappear when using Xe as opposed to He as the carrier gas. We attribute this phenomenonmore » to cluster formation between Xe and pyrrole, and this assumption is supported by observation of resonance enhanced multiphoton ionization spectra for the (Xe…pyrrole) cluster followed by photofragmentation of the nascent cation cluster. Ab initio calculations are performed to support the experimental data. Part of this work is supported by the transfer of knowledge program SOUTHERN DYNAMICS MTKD-CT-2004-014306. The experimental work was performed at the Ultraviolet Laser Facility operating at IESL-FORTH and has been supported in part by the European Commission through the Research Infrastructures activity of FP6 (“Laserlab- Europe” RII3-CT-2003-506350). We also wish to thank the graduate program Applied Molecular Spectroscopy (EPEAEK). Part of this work was supported by the Division of Chemical Sciences, Geosciences and Biosciences, Office of Basic Energy Sciences, US Department of Energy with Battelle Memorial Institute, which operates the Pacific Northwest National Laboratory. Computer resources were provided by the Office of Science, US Department of Energy.« less

Dispersion, Mixing, and Combustion in Uniform- and Variable-Density Air-Breathing High-Speed Propulsion Flows

DTIC Science & Technology

2013-08-28

and dispersion whose behavior is relevant to fuel-injection in propulsion devices. The latter investigations were conducted in water that allows...initially sharp scalar gradients in this high Schmidt-number fluid medium ( water : ⁄ ). Generally, such scalar plumes re reported to exhibit... Flowmetering : The Characteristics of Cylindrical Nozzles with Sharp Upstream Edges. Int. J. Heat and Fluid Flow 1(3):123-132. 3. Research personnel

Relationship between sharps disposal containers and Clostridium difficile infections in acute care hospitals.

PubMed

Pogorzelska-Maziarz, Monika

2015-10-01

Sharps disposal containers are ubiquitous in health care facilities; however, there is paucity of data on their potential role in pathogen transmission. This study assessed the relationship between use of single-use versus reusable sharps containers and rates of Clostridium difficile infections in a national sample of hospitals. A 2013 survey of 1,990 hospitals collected data on the use of sharps containers. Responses were linked to the 2012 Medicare Provider Analysis and Review dataset. Bivariate and multivariable negative binomial regression were conducted to examine differences in C difficile rates between hospitals using single-use versus reusable containers. There were 604 hospitals who completed the survey; of these, 539 provided data on use of sharps containers in 2012 (27% response rate). Hospitals had, on average, 289 beds (SD ± 203) and were predominantly non-for-profit (67%) and nonteaching (63%). Most used reusable sharps containers (72%). In bivariate regression, hospitals using single-use containers had significantly lower rates of C difficile versus hospitals using reusable containers (incidence rate ratio [IRR] = 0.846, P = .001). This relationship persisted in multivariable regression (IRR = 0.870, P = .003) after controlling for other hospital characteristics. This is the first study to show a link between use of single-use sharps containers and lower C difficile rates. Future research should investigate the potential for environmental contamination of reusable containers and the role they may play in pathogen transmission. Copyright © 2015 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Risk of Potential Exposure Incident in Non-healthcare Workers in Contact with Infectious and Municipal Waste

PubMed Central

Kanisek, Sanja; Gmajnić, Rudika; Barać, Ivana

2018-01-01

Abstract Introduction The proper classification of sharp and infectious waste in situ by the healthcare workers is an important measure of prevention of sharps and other exposure incidents in non-healthcare workers, who handle such waste. The aim was to examine the practice of classifying sharp and infectious waste in family and dental practices. Methods An analysis of 50 bags of infectious and 50 bags of municipal waste from five family and five dental practices for five days in October 2016 at the Health centre Osijek. Results Healthcare workers in 70% of the practices deposited sharps in infectious waste. In 56% of infectious waste bags, sharp object were found. More risky bags of infectious waste were produced by family practices (64%), but with no significant differences in relation to dental practices (48%), (P=0.143). Disposing of infectious into municipal waste was the case in 90% of the practitioners, where in 60% of municipal waste bags, infectious waste was disposed. Dental practices produced more risky bags of municipal waste (76%) in relation to family practices (44%), but with no significant difference (P=0.714). Conclusions The results of this research point to importance of performing audits of proper disposal of sharps and infectious waste to reduce the risks of injury to non-healthcare workers who come into contact with the said waste. Given results could be used for framing written protocols of proper disposal of sharps and infectious waste that should be visibly available in family and dental practices and for education of healthcare workers. PMID:29651317

Building a robust, scalable and standards-driven infrastructure for secondary use of EHR data: the SHARPn project.

PubMed

Rea, Susan; Pathak, Jyotishman; Savova, Guergana; Oniki, Thomas A; Westberg, Les; Beebe, Calvin E; Tao, Cui; Parker, Craig G; Haug, Peter J; Huff, Stanley M; Chute, Christopher G

2012-08-01

The Strategic Health IT Advanced Research Projects (SHARP) Program, established by the Office of the National Coordinator for Health Information Technology in 2010 supports research findings that remove barriers for increased adoption of health IT. The improvements envisioned by the SHARP Area 4 Consortium (SHARPn) will enable the use of the electronic health record (EHR) for secondary purposes, such as care process and outcomes improvement, biomedical research and epidemiologic monitoring of the nation's health. One of the primary informatics problem areas in this endeavor is the standardization of disparate health data from the nation's many health care organizations and providers. The SHARPn team is developing open source services and components to support the ubiquitous exchange, sharing and reuse or 'liquidity' of operational clinical data stored in electronic health records. One year into the design and development of the SHARPn framework, we demonstrated end to end data flow and a prototype SHARPn platform, using thousands of patient electronic records sourced from two large healthcare organizations: Mayo Clinic and Intermountain Healthcare. The platform was deployed to (1) receive source EHR data in several formats, (2) generate structured data from EHR narrative text, and (3) normalize the EHR data using common detailed clinical models and Consolidated Health Informatics standard terminologies, which were (4) accessed by a phenotyping service using normalized data specifications. The architecture of this prototype SHARPn platform is presented. The EHR data throughput demonstration showed success in normalizing native EHR data, both structured and narrative, from two independent organizations and EHR systems. Based on the demonstration, observed challenges for standardization of EHR data for interoperable secondary use are discussed. Copyright © 2012 Elsevier Inc. All rights reserved.

Building a robust, scalable and standards-driven infrastructure for secondary use of EHR data: The SHARPn project

PubMed Central

Rea, Susan; Pathak, Jyotishman; Savova, Guergana; Oniki, Thomas A.; Westberg, Les; Beebe, Calvin E.; Tao, Cui; Parker, Craig G.; Haug, Peter J.; Huff, Stanley M.; Chute, Christopher G.

2016-01-01

The Strategic Health IT Advanced Research Projects (SHARP) Program, established by the Office of the National Coordinator for Health Information Technology in 2010 supports research findings that remove barriers for increased adoption of health IT. The improvements envisioned by the SHARP Area 4 Consortium (SHARPn) will enable the use of the electronic health record (EHR) for secondary purposes, such as care process and outcomes improvement, biomedical research and epidemiologic monitoring of the nation’s health. One of the primary informatics problem areas in this endeavor is the standardization of disparate health data from the nation’s many health care organizations and providers. The SHARPn team is developing open source services and components to support the ubiquitous exchange, sharing and reuse or ‘liquidity’ of operational clinical data stored in electronic health records. One year into the design and development of the SHARPn framework, we demonstrated end to end data flow and a prototype SHARPn platform, using thousands of patient electronic records sourced from two large healthcare organizations: Mayo Clinic and Intermountain Healthcare. The platform was deployed to (1) receive source EHR data in several formats, (2) generate structured data from EHR narrative text, and (3) normalize the EHR data using common detailed clinical models and Consolidated Health Informatics standard terminologies, which were (4) accessed by a phenotyping service using normalized data specifications. The architecture of this prototype SHARPn platform is presented. The EHR data throughput demonstration showed success in normalizing native EHR data, both structured and narrative, from two independent organizations and EHR systems. Based on the demonstration, observed challenges for standardization of EHR data for interoperable secondary use are discussed. PMID:22326800

Growth of a Pharmacy School Through Planning, Cooperation, and Establishment of a Satellite Campus

PubMed Central

Roffman, David S.; Cooper, William J.

2009-01-01

University of Maryland School of Pharmacy was in a quandary: its comprehensive mission required meeting state workforce needs while increasing educational quality, expanding research, and responding to service needs, but state resources were declining, faculty members were stressed, construction of a long-needed new building was stalled, and pressure to increase doctor of pharmacy (PharmD) enrollment was growing. A sharp challenge from the Board of Regents mobilized the school to quickly launch a growth initiative to accelerate PharmD program expansion through a satellite campus. Within 4 months, a plan was approved that not only led to enrollment growth, but also to a significant expansion of the faculty and staff, increased operating and capital budgets, and ground breaking for an $83 million new building. This case study illustrates how seemingly competitive needs such as teaching, research, and service can be woven together synergistically to accomplish multiple goals. PMID:19885071

Scientific approaches to AIDS prevention and control in China.

PubMed

Teng, T; Shao, Y

2011-04-01

The HIV epidemic in China started among intravenous drug users in the late 1980s. The second wave of the epidemic was caused by an outbreak in the paid plasma donors in central China in the mid-1990s. Sexually transmitted HIV cases have steadily increased and comprised more than half the reported HIV/AIDS infections since 2007. In the last 5 years, there has been a sharp increase of HIV infection in men who have sex with men. The HIV epidemic in China has expanded from high-risk groups to the general population and from rural regions to urban areas. This brief article discusses the history of HIV epidemics in China and the challenges facing the current AIDS control efforts in the country. It explains that only scientific approaches can sustain the national AIDS control programs and introduce the type of research needed to address those challenges. The selected research areas include molecular epidemiology, drug resistance surveillance, and the Chinese HIV vaccine research.

Electrostatic atomization: Effect of electrode materials on electrostatic atomizer performance

NASA Astrophysics Data System (ADS)

Sankaran, Abhilash; Staszel, Christopher; Kashir, Babak; Perri, Anthony; Mashayek, Farzad; Yarin, Alexander

2016-11-01

Electrostatic atomization was studied experimentally with a pointed electrode in a converging nozzle. Experiments were carried out on poorly conductive canola oil where it was observed that electrode material may affect charge transfer. This points at the possible faradaic reactions that can occur at the surfaces of the electrodes. The supply voltage is applied to the sharp electrode and the grounded nozzle body constitutes the counter-electrode. The charge transfer is controlled by the electrochemical reactions on both the electrodes. The electrical performance study of the atomizer issuing a charged oil jet was conducted using three different nozzle body materials - brass, copper and stainless steel. Also, two sharp electrode materials - brass and stainless steel - were tested. The experimental results revealed that both the nozzle body material, as well as the sharp electrode material affected the spray and leak currents. Moreover, the effect of the sharp electrode material is quite significant. This research is supported by NSF Grant 1505276.

Comparing non-safety with safety device sharps injury incidence data from two different occupational surveillance systems.

PubMed

Mitchell, A H; Parker, G B; Kanamori, H; Rutala, W A; Weber, D J

2017-06-01

The United States Occupational Safety and Health Administration (OSHA) Bloodborne Pathogens Standard as amended by the Needlestick Safety and Prevention Act requiring the use of safety-engineered medical devices to prevent needlesticks and sharps injuries has been in place since 2001. Injury changes over time include differences between those from non-safety compared with safety-engineered medical devices. This research compares two US occupational incident surveillance systems to determine whether these data can be generalized to other facilities and other countries either with legislation in place or considering developing national policies for the prevention of sharps injuries among healthcare personnel. Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Patents for critical pharmaceuticals: the AZT case.

PubMed

Ackiron, E

1991-01-01

Patents and other statutory types of market protections are used in the United States to promote scientific research and innovation. This incentive is especially important in research intensive fields such as the pharmaceutical industry. Unfortunately, these same protections often result in higher monopoly pricing once a successful product is brought to market. Usually this consequence is viewed as the necessary evil of an incentive system that encourages costly research and development by promising large rewards to the successful inventor. However, in the case of the AIDS drug Zidovudine (AZT), the high prices charged by the pharmaceutical company owning the drug have led to public outcry and a re-examination of government incentive systems. This Note traces the evolution of these incentive programs--the patent system, and, to a lesser extent, the orphan drug program--and details the conflicting interests involved in their development. It then demonstrates how the AZT problem brings the interest of providing inventors with incentives for risky innovative efforts into a sharp collision with the ultimate goal of such systems: ensuring that the public has access to the resulting products at a reasonable price. Finally, the Note describes how Congress and the courts have attempted to resolve these problems in the past, and how they might best try to solve the AZT problem in the near future.

Characteristics of Pediatric Antimicrobial Stewardship Programs: Current Status of the Sharing Antimicrobial Reports for Pediatric Stewardship (SHARPS) Collaborative

PubMed Central

McPherson, Christopher; Lee, Brian R.; Terrill, Cindy; Hersh, Adam L.; Gerber, Jeffrey S.; Kronman, Matthew P.; Newland, Jason G.

2018-01-01

In response to the growing epidemic of antibiotic-resistant bacterial infections, antimicrobial stewardship programs (ASP) have been rapidly implemented in the United States (US). This study examines the prevalence of the Centers for Disease Control and Prevention’s (CDC) seven core elements of a successful ASP within a large subset of US Children’s Hospitals. In 2016, a survey was conducted of 52 pediatric hospitals assessing the presence of the seven core elements: leadership commitment, accountability, drug expertise, action, tracking, reporting, and education. Forty-nine hospitals (94%) had established ASPs and 41 hospitals (79%) included all seven core elements. Physician accountability (87%) and a dedicated ASP pharmacist or drug expert (88%) were present in the vast majority of hospitals. However, substantial variability existed in the financial support allotted to these positions. This variability did not predict program actions, tracking, reporting, and education. When compared with previous surveys, these results document a dramatic increase in the prevalence and resources of pediatric stewardship programs, although continued expansion is warranted. Further research is required to understand the feasibility of various core stewardship activities and the impact on patient outcomes in the setting of finite resources. PMID:29370071

Characteristics of Pediatric Antimicrobial Stewardship Programs: Current Status of the Sharing Antimicrobial Reports for Pediatric Stewardship (SHARPS) Collaborative.

PubMed

McPherson, Christopher; Lee, Brian R; Terrill, Cindy; Hersh, Adam L; Gerber, Jeffrey S; Kronman, Matthew P; Newland, Jason G

2018-01-25

In response to the growing epidemic of antibiotic-resistant bacterial infections, antimicrobial stewardship programs (ASP) have been rapidly implemented in the United States (US). This study examines the prevalence of the Centers for Disease Control and Prevention's (CDC) seven core elements of a successful ASP within a large subset of US Children's Hospitals. In 2016, a survey was conducted of 52 pediatric hospitals assessing the presence of the seven core elements: leadership commitment, accountability, drug expertise, action, tracking, reporting, and education. Forty-nine hospitals (94%) had established ASPs and 41 hospitals (79%) included all seven core elements. Physician accountability (87%) and a dedicated ASP pharmacist or drug expert (88%) were present in the vast majority of hospitals. However, substantial variability existed in the financial support allotted to these positions. This variability did not predict program actions, tracking, reporting, and education. When compared with previous surveys, these results document a dramatic increase in the prevalence and resources of pediatric stewardship programs, although continued expansion is warranted. Further research is required to understand the feasibility of various core stewardship activities and the impact on patient outcomes in the setting of finite resources.

Solution Methods for Stochastic Dynamic Linear Programs.

DTIC Science & Technology

1980-12-01

16, No. 11, pp. 652-675, July 1970. [28] Glassey, C.R., "Dynamic linear programs for production scheduling", OR 19, pp. 45-56. 1971 . 129 Glassey, C.R...Huang, C.C., I. Vertinsky, W.T. Ziemba, ’Sharp bounds on the value of perfect information", OR 25, pp. 128-139, 1977. [37 Kall , P., ’Computational... 1971 . [701 Ziemba, W.T., *Computational algorithms for convex stochastic programs with simple recourse", OR 8, pp. 414-431, 1970. 131 UNCLASSI FIED

Scientometric indicators for Brazilian research on High Energy Physics, 1983-2013.

PubMed

Alvarez, Gonzalo R; Vanz, Samile A S; Barbosa, Marcia C

2017-01-01

This article presents an analysis of Brazilian research on High Energy Physics (HEP) indexed by Web of Science (WoS) from 1983 to 2013. Scientometric indicators for output, collaboration and impact were used to characterize the field under study. The results show that the Brazilian articles account for 3% of total HEP research worldwide and that the sharp rise in the scientific activity between 2009 and 2013 may have resulted from the consolidation of graduate programs, the increase of the funding and of the international collaboration as well as the implementation of the Rede Nacional de Física de Altas Energias (RENAFAE) in 2008. Our results also indicate that the collaboration patterns in terms of the authors, the institutions and the countries confirm the presence of Brazil in multinational Big Science experiments, which may also explain the prevalence of foreign citing documents (all types), emphasizing the international prestige and visibility of the output of Brazilian scientists. We concluded that the scientometric indicators suggested scientific maturity in the Brazilian HEP community due to its long history of experimental research.

Work Disability Among Native-born and Foreign-born Americans: On Origins, Health, and Social Safety Nets.

PubMed

Engelman, Michal; Kestenbaum, Bert M; Zuelsdorff, Megan L; Mehta, Neil K; Lauderdale, Diane S

2017-12-01

Public debates about both immigration policy and social safety net programs are increasingly contentious. However, little research has explored differences in health within America's diverse population of foreign-born workers, and the effect of these workers on public benefit programs is not well understood. We investigate differences in work disability by nativity and origins and describe the mix of health problems associated with receiving Social Security Disability Insurance benefits. Our analysis draws on two large national data sources-the American Community Survey and comprehensive administrative records from the Social Security Administration-to determine the prevalence and incidence of work disability between 2001 and 2010. In sharp contrast to prior research, we find that foreign-born adults are substantially less likely than native-born Americans to report work disability, to be insured for work disability benefits, and to apply for those benefits. Overall and across origins, the foreign-born also have a lower incidence of disability benefit award. Persons from Africa, Northern Europe, Canada, and parts of Asia have the lowest work disability benefit prevalence rates among the foreign-born; persons from Southern Europe, Western Europe, the former Soviet Union, and the Caribbean have the highest rates.

Fully developed pipe and triangular channel flow measurement using Magnetic Resonance Velocimetry

NASA Astrophysics Data System (ADS)

Baek, Seungchan; Hwang, Wontae

2017-11-01

Magnetic resonance velocimetry (MRV) is a non-intrusive flow visualization method which is able to measure the 3 dimensional 3 component (3D3C) mean velocity field in complex geometries, using a healthcare MRI scanner. Since this technique is based on nuclear magnetic resonance (NMR), it is free from optical distortion and does not require tracer particles. Due to these powerful advantages, MRV usage is gradually expanding from biomedical fields to the engineering domain. In this study, we validate the performance of MRV by measuring fully developed pipe flow and compare measured data with time averaged DNS data. We then investigate the overall flow characteristics in a triangular channel with a sharp corner. At the sharp corner, boundary layer effects dominate and the effect of turbulence is reduced. This information has implications for engineering applications such as flow in a turbine blade internal cooling passage at the sharp trailing edge. This research was supported by the Seoul National University Research Grant in 2017, and Doosan Heavy Industries & Construction. (Contract No. 2016900298 and 2017900095).

Influence and evolution mechanism of different sharpness contact forms to mechanical property of cortical bone by nanoindentation

NASA Astrophysics Data System (ADS)

Sun, Xingdong; Guo, Yue; Li, Lijia; Liu, Zeyang; Wu, Di; Shi, Dong; Zhao, Hongwei; Zhang, Shizhong

2018-03-01

Based on different damage forms of various contact forms to bone, the mechanical response and mechanism were investigated by nanoindentation under different sharpness contact forms. For the purpose of simulating the different sharpness contact forms, two kinds of indenters were used in experiments and finite elements simulations. Through nanoindentation experiments, it was concluded that the residual depth of sharp indenter was bigger than that of blunt indenter with small penetration depth. However, the contrary law was obtained with bigger penetration depth. There was a turning point of transition from blunt tendency to sharp tendency. By calculation, it was concluded that the sharper the indenter was, the bigger the proportion of plastic energy in total energy was. Basically, results of finite elements simulation could correspond with the experimental conclusions. By the observation of FE-SEM, the surface of cortical bone compressed was more seriously directly below the blunt indenter than the lateral face. For the berkovich indenter, the surface of indentation compressed was less directly below the indenter, but seriously on three lateral faces. This research may provide some new references to the studies of bone fracture mechanism in different load patterns in the initial press-in stage and offer new explanation for bone trauma diagnosis in clinical treatment and criminal investigation.

Sharp and the Jules Verne Launcher

NASA Astrophysics Data System (ADS)

Hunter, John; Cartland, Harry

1996-03-01

Lawrence Livermore National Laboratory (LLNL) has built the worlds largest hydrogen gas gun called SHARP, (Super High Altitude Research Project). Originally designed to launch 5 kg to a 450 km altitude, SHARP is configured horizontally at Site 300 in Tracy, California. SHARP is successfully delivering 5 kg scramjets at Mach 9 in aerophysics tests. Some of the results of the scramjet tests are enlightening and are presented insofar as they are relevant to future launches into space. Using a light gas gun to launch payloads into orbit has been analyzed. We look at LEO (Low Earth Orbit), GEO (Geosynchronous Earth Orbit), and LO (Lunar Orbit). We present a conceptual design for a large light gas gun called the Jules Verne Launcher (JVL). The JVL can deliver 3.3 metric tons to a 500 km low earth orbit. We anticipate one launch per day. We present the history of light gas guns, the SHARP design and performance, and the JVL design. Another section is devoted to the vehicle environment and resultant design. Lastly, we present a cost analysis. Our results indicated that the JVL will be able to deliver 1000 metric tons of payload to LEO yearly. The cost will be 5% of the best US rocket delivery cost. This technology will enable the next phase of man's exploration of space.

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, SHARPE MANUFACTURING TITANIUM T1-CG SPRAY GUN

EPA Science Inventory

Under EPA’s Environmental Technology Verification program, which provides objective and scientific third party analysis of new technology that can benefit the environment, the pollution prevention capabilities of a high transfer efficiency liquid spray gun was tested. This ...

Tilt changes of short duration

USGS Publications Warehouse

McHugh, Stuart

1976-01-01

Section I of this report contains a classification scheme for short period tilt data. For convenience, all fluctuations in the local tilt field of less than 24 hours duration will be designated SP (i.e., short period) tilt events. Three basic categories of waveshape appearance are defined, and the rules for naming the waveforms are outlined. Examples from tilt observations at four central California sites are provided. Section II contains some coseismic tilt data. Fourteen earthquakes in central California, ranging in magnitude from 2.9 to 5.2, were chosen for study on four tiltmeters within 10 source dimensions of the epicenters. The raw records from each of the four tiltmeters at the times of the earthquakes were photographed and are presented in this section. Section III contains documentation of computer programs used in the analysis of the short period tilt data. Program VECTOR computes the difference vector of a tilt event and displays the sequence of events as a head-to-tail vector plot. Program ONSTSP 1) requires two component digitized tilt data as input, 2) scales and plots the data, and 3) computes and displays the amplitude, azimuth, and normalized derivative of the tilt amplitude. Program SHARPS computes the onset sharpness, (i.e., the normalized derivative of the tilt amplitude at the onset of the tilt event) as a function of source-station distance from a model of creep-related tilt changes. Program DSPLAY plots the digitized data.

Occupational Health Update: Focus on Preventing the Acquisition of Infections with Pre-exposure Prophylaxis and Postexposure Prophylaxis.

PubMed

Weber, David J; Rutala, William A

2016-09-01

Health care personnel are commonly exposed to infectious agents via sharp injuries (eg, human immunodeficiency virus, hepatitis B virus, and hepatitis C virus), direct patient care (eg, pertussis and meningococcus), and the contaminated environment (eg, Clostridium difficile). An effective occupational program is a key aspect of preventing acquisition of an infection by offering the following: (1) education of health care personnel regarding proper handling of sharps, early identification and isolation of potentially infectious patients, and hand hygiene; (2) assuring immunity to vaccine-preventable diseases; and, (3) immediate availability of a medical evaluation after a nonprotected exposure to an infectious disease. Copyright © 2016 Elsevier Inc. All rights reserved.

Performance of Handicapped Students in a Competency Testing Program.

ERIC Educational Resources Information Center

Serow, Robert C.; O'Brien, Kathleen

1983-01-01

Samples of handicapped and nonhandicapped pupils were compared on the following: initial Minimum Competency Test (MCT) performance, participation in remediation, improvements in subsequent MCT, and eligibility for receiving high school diplomas. Nonhandicapped pupils generally fared better on all measures, although sharp differences were found…

Glitch game testers: The design and study of a learning environment for computational production with young African American males

NASA Astrophysics Data System (ADS)

DiSalvo, Elizabeth Betsy

The implementation of a learning environment for young African American males, called the Glitch Game Testers, was launched in 2009. The development of this program was based on formative work that looked at the contrasting use of digital games between young African American males and individuals who chose to become computer science majors. Through analysis of cultural values and digital game play practices, the program was designed to intertwine authentic game development practices and computer science learning. The resulting program employed 25 African American male high school students to test pre-release digital games full-time in the summer and part-time in the school year, with an hour of each day dedicated to learning introductory computer science. Outcomes for persisting in computer science education are remarkable; of the 16 participants who had graduated from high school as of 2012, 12 have gone on to school in computing-related majors. These outcomes, and the participants' enthusiasm for engaging in computing, are in sharp contrast to the crisis in African American male education and learning motivation. The research presented in this dissertation discusses the formative research that shaped the design of Glitch, the evaluation of the implementation of Glitch, and a theoretical investigation of the way in which participants navigated conflicting motivations in learning environments.

Lock-in of elastically mounted airfoils at a 90° angle of attack

NASA Astrophysics Data System (ADS)

Ehrmann, R. S.; Loftin, K. M.; Johnson, S.; White, E. B.

2014-01-01

Reducing vortex-induced vibration (VIV) of elastically mounted cylinders has applications to petroleum, nuclear, and civil engineering. One simple method is streamlining the cylinder into an airfoil shape. However, if flow direction changes, an elastic airfoil could experience similar oscillations with even more drag. To better understand a general airfoil's response, three elastically mounted airfoil shapes are tested at a 90° angle of attack in a 3 ft by 4 ft wind tunnel. The shapes are a NACA 0018, a sharp leading- and trailing-edge (sharp-sharp) model, and a round leading- and trailing-edge (round-round) model. Mass-damping ranges from 0.96 to 1.44. For comparison to canonical VIV research, a cylinder is also tested. Since lock-in occurs near Rec=125×103, the models are also tested with a trip strip. The NACA 0018 and sharp-sharp configuration show nearly identical responses. The cylinder and round-round airfoil have responses five to eight times larger. Thus, the existence of a single sharp edge is sufficient to greatly reduce VIV at 90° angle of attack. Whereas the cylinder and round-round maximum response amplitudes are similar, cylinder lock-in occurs over a velocity range three times larger than the round-round. The tripped cylinder and round-round models' response is attenuated by 70% compared to their respective clean configurations. Hysteresis is only observed in the circular cylinder and round-round models. Hotwire data indicates the clean cylinder has a unique vortex pattern compared to the other configurations.

Not Working: Unskilled Youth and Displaced Adults. A Look at the Demographic, Technological, and Educational Causes of Youth and Adult Unemployment and at Some Program Responses of the Ford Foundation. A Working Paper.

ERIC Educational Resources Information Center

Ford Foundation, New York, NY.

While minority youth and adults have traditionally experienced high rates of unemployment, recent demographic, educational, and technological changes have all combined to cause a sharp increase in the numbers of unemployed and displaced minority group workers. A review of past employment and training programs such as the Comprehensive Employment…

Proceedings of the NASA Workshop on Registration and Rectification

NASA Technical Reports Server (NTRS)

Bryant, N. A. (Editor)

1982-01-01

Issues associated with the registration and rectification of remotely sensed data. Near and long range applications research tasks and some medium range technology augmentation research areas are recommended. Image sharpness, feature extraction, inter-image mapping, error analysis, and verification methods are addressed.

29 CFR 1910.1030 - Bloodborne pathogens.

Code of Federal Regulations, 2010 CFR

2010-07-01

... designated representative. Engineering controls means controls (e.g., sharps disposal containers, self...-volume or high concentration production of HIV or HBV. Regulated Waste means liquid or semi-liquid blood... research-laboratory-scale amounts of HIV or HBV. Research laboratories may produce high concentrations of...

The Issue of Quality in Qualitative Research

ERIC Educational Resources Information Center

Hammersley, Martyn

2007-01-01

This article addresses the perennial issue of the criteria by which qualitative research should be evaluated. At the present time, there is a sharp conflict between demands for explicit criteria, for example in order to serve systematic reviewing and evidence-based practice, and arguments on the part of some qualitative researchers that such…

A Model for Postdoctoral Education That Promotes Minority and Majority Success in the Biomedical Sciences.

PubMed

Eisen, Arri; Eaton, Douglas C

2017-01-01

How does the United States maintain the highest-quality research and teaching in its professional science workforce and ensure that those in this workforce are effectively trained and representative of national demographics? In the pathway to science careers, the postdoctoral stage is formative, providing the experiences that define the independent work of one's first faculty position. It is also a stage in which underrepresented minorities (URMs) disproportionately lose interest in pursuing academic careers in science and, models suggest, a point at which interventions to increase proportions of URMs in such careers could be most effective. We present a mixed-methods, case study analysis from 17 years of the Fellowships in Research and Science Teaching (FIRST) postdoctoral program, to our knowledge the largest and longest continuously running science postdoctoral program in the United States. We demonstrate that FIRST fellows, in sharp contrast to postdocs overall, are inclusive of URMs (50% African American; 70% women) and as or more successful in their fellowships and beyond as a comparison group (measured by publication rate, attainment of employment in academic science careers, and eventual research grant support). Analysis of alumni surveys and focus group discussions reveals that FIRST fellows place highest value on the cohort-driven community and the developmental teaching and research training the program provides. © 2017 A. Eisen and D. C. Eaton. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

DSMC simulations of shock interactions about sharp double cones

NASA Astrophysics Data System (ADS)

Moss, James N.

2001-08-01

This paper presents the results of a numerical study of shock interactions resulting from Mach 10 flow about sharp double cones. Computations are made by using the direct simulation Monte Carlo (DSMC) method of Bird. The sensitivity and characteristics of the interactions are examined by varying flow conditions, model size, and configuration. The range of conditions investigated includes those for which experiments have been or will be performed in the ONERA R5Ch low-density wind tunnel and the Calspan-University of Buffalo Research Center (CUBRC) Large Energy National Shock (LENS) tunnel.

DSMC Simulations of Shock Interactions About Sharp Double Cones

NASA Technical Reports Server (NTRS)

Moss, James N.

2000-01-01

This paper presents the results of a numerical study of shock interactions resulting from Mach 10 flow about sharp double cones. Computations are made by using the direct simulation Monte Carlo (DSMC) method of Bird. The sensitivity and characteristics of the interactions are examined by varying flow conditions, model size, and configuration. The range of conditions investigated includes those for which experiments have been or will be performed in the ONERA R5Ch low-density wind tunnel and the Calspan-University of Buffalo Research Center (CUBRC) Large Energy National Shock (LENS) tunnel.

Standard Hardware Acquisition and Reliability Program's (SHARP's) efforts in incorporating fiber optic interconnects into standard electronic module (SEM) connectors

NASA Astrophysics Data System (ADS)

Riggs, William R.

1994-05-01

SHARP is a Navy wide logistics technology development effort aimed at reducing the acquisition costs, support costs, and risks of military electronic weapon systems while increasing the performance capability, reliability, maintainability, and readiness of these systems. Lower life cycle costs for electronic hardware are achieved through technology transition, standardization, and reliability enhancement to improve system affordability and availability as well as enhancing fleet modernization. Advanced technology is transferred into the fleet through hardware specifications for weapon system building blocks of standard electronic modules, standard power systems, and standard electronic systems. The product lines are all defined with respect to their size, weight, I/O, environmental performance, and operational performance. This method of defining the standard is very conducive to inserting new technologies into systems using the standard hardware. This is the approach taken thus far in inserting photonic technologies into SHARP hardware. All of the efforts have been related to module packaging; i.e. interconnects, component packaging, and module developments. Fiber optic interconnects are discussed in this paper.

Impact of Competency-Based Education and Assessment on Program Outcomes

ERIC Educational Resources Information Center

Konkoth, Shanthi

2016-01-01

Since the publication of the "College Scorecard" by The U.S. Department of Education in 2015, comparisons between college attendance costs and institutional outcomes (i.e., graduation rates, post-graduation earnings) have come into sharp focus. This increased scrutiny requires institutions of higher learning to be more transparent about…

Cosmic String Searches

NASA Astrophysics Data System (ADS)

Hoffman, Y.; Hogan, C.

The author discusses observational strategies for finding effects associated with the gravitational lensing of distant objects by strings. In particular, the requirements of a survey to find chains of galaxy image pairs or single galaxies with sharp edges are studied in some detail, and a proposed search program at Steward Observatory is described.

An overview of a 5-year research program on acid deposition in China

NASA Astrophysics Data System (ADS)

Wang, T.; He, K.; Xu, X.; Zhang, P.; Bai, Y.; Wang, Z.; Zhang, X.; Duan, L.; Li, W.; Chai, F.

2011-12-01

Despite concerted research and regulative control of sulfur dioxide in China, acid rain remained a serious environmental issue, due to a sharp increase in the combustion of fossil fuel in the 2000s. In 2005, the Ministry of Science and Technology of China funded a five-year comprehensive research program on acid deposition. This talk will give an overview of the activities and the key findings from this study, covering emission, atmospheric processes, and deposition, effects on soil and stream waters, and impact on typical trees/plants in China. The main results include (1) China still experiences acidic rainfalls in southern and eastern regions, although the situation has stabilized after 2006 due to stringent control of SO2 by the Chinese Government; (2) Sulfate is the dominant acidic compound, but the contribution of nitrate has increased; (3) cloud-water composition in eastern China is strongly influenced by anthropogenic emissions; (4) the persistent fall of acid rain in the 30 years has lead to acidification of some streams/rivers and soils in southern China; (5) the studied plants have shown varying response to acid rain; (6) some new insights have been obtained on atmospheric chemistry, atmospheric transport, soil chemistry, and ecological impacts, some of which will be discussed in this talk. Compared to the situation in North America and Europe, China's acid deposition is still serious, and continued control of sulfur and nitrogen emission is required. There is an urgent need to establish a long-term observation network/program to monitor the impact of acid deposition on soil, streams/rivers/lakes, and forests.

Real time mitigation of atmospheric turbulence in long distance imaging using the lucky region fusion algorithm with FPGA and GPU hardware acceleration

NASA Astrophysics Data System (ADS)

Jackson, Christopher Robert

"Lucky-region" fusion (LRF) is a synthetic imaging technique that has proven successful in enhancing the quality of images distorted by atmospheric turbulence. The LRF algorithm selects sharp regions of an image obtained from a series of short exposure frames, and fuses the sharp regions into a final, improved image. In previous research, the LRF algorithm had been implemented on a PC using the C programming language. However, the PC did not have sufficient sequential processing power to handle real-time extraction, processing and reduction required when the LRF algorithm was applied to real-time video from fast, high-resolution image sensors. This thesis describes two hardware implementations of the LRF algorithm to achieve real-time image processing. The first was created with a VIRTEX-7 field programmable gate array (FPGA). The other developed using the graphics processing unit (GPU) of a NVIDIA GeForce GTX 690 video card. The novelty in the FPGA approach is the creation of a "black box" LRF video processing system with a general camera link input, a user controller interface, and a camera link video output. We also describe a custom hardware simulation environment we have built to test the FPGA LRF implementation. The advantage of the GPU approach is significantly improved development time, integration of image stabilization into the system, and comparable atmospheric turbulence mitigation.

Identifying Future Scientists: Predicting Persistence into Research Training

PubMed Central

2007-01-01

This study used semistructured interviews and grounded theory to look for characteristics among college undergraduates that predicted persistence into Ph.D. and M.D./Ph.D. training. Participants in the summer undergraduate and postbaccalaureate research programs at the Mayo Clinic College of Medicine were interviewed at the start, near the end, and 8–12 months after their research experience. Of more than 200 themes considered, five characteristics predicted those students who went on to Ph.D. and M.D./Ph.D. training or to M.D. training intending to do research: 1) Curiosity to discover the unknown, 2) Enjoyment of problem solving, 3) A high level of independence, 4) The desire to help others indirectly through research, and 5) A flexible, minimally structured approach to the future. Web-based surveys with different students confirmed the high frequency of curiosity and/or problem solving as the primary reason students planned research careers. No evidence was found for differences among men, women, and minority and nonminority students. Although these results seem logical compared with successful scientists, their constancy, predictive capabilities, and sharp contrast to students who chose clinical medicine were striking. These results provide important insights into selection and motivation of potential biomedical scientists and the early experiences that will motivate them toward research careers. PMID:18056303

Identifying future scientists: predicting persistence into research training.

PubMed

McGee, Richard; Keller, Jill L

2007-01-01

This study used semistructured interviews and grounded theory to look for characteristics among college undergraduates that predicted persistence into Ph.D. and M.D./Ph.D. training. Participants in the summer undergraduate and postbaccalaureate research programs at the Mayo Clinic College of Medicine were interviewed at the start, near the end, and 8-12 months after their research experience. Of more than 200 themes considered, five characteristics predicted those students who went on to Ph.D. and M.D./Ph.D. training or to M.D. training intending to do research: 1) Curiosity to discover the unknown, 2) Enjoyment of problem solving, 3) A high level of independence, 4) The desire to help others indirectly through research, and 5) A flexible, minimally structured approach to the future. Web-based surveys with different students confirmed the high frequency of curiosity and/or problem solving as the primary reason students planned research careers. No evidence was found for differences among men, women, and minority and nonminority students. Although these results seem logical compared with successful scientists, their constancy, predictive capabilities, and sharp contrast to students who chose clinical medicine were striking. These results provide important insights into selection and motivation of potential biomedical scientists and the early experiences that will motivate them toward research careers.

Air Force Officers Visit Aircraft Engine Research Laboratory

NASA Image and Video Library

1945-08-21

A group of 60 Army Air Forces officers visited the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory on August 27, 1945. The laboratory enacted strict security regulations throughout World War II. During the final months of the war, however, the NACA began opening its doors to groups of writers, servicemen, and aviation industry leaders. These events were the first exposure of the new engine laboratory to the outside world. Grandstands were built alongside the Altitude Wind Tunnel specifically for group photographs. George Lewis, Raymond Sharp, and Addison Rothrock (right to left) addressed this group of officers in the Administration Building auditorium. Lewis was the NACA’s Director of Aeronautical Research, Sharp was the lab’s manager, and Rothrock was the lab’s chief of research. Abe Silverstein, Jesse Hall and others watch from the rear of the room. The group toured several facilities after the talks, including the Altitude Wind Tunnel and a new small supersonic wind tunnel. The visit concluded with a NACA versus Army baseball game and cookout.

Sharp Refractory Composite Leading Edges on Hypersonic Vehicles

NASA Technical Reports Server (NTRS)

Walker, Sandra P.; Sullivan, Brian J.

2003-01-01

On-going research of advanced sharp refractory composite leading edges for use on hypersonic air-breathing vehicles is presented in this paper. Intense magnitudes of heating and of heating gradients on the leading edge lead to thermal stresses that challenge the survivability of current material systems. A fundamental understanding of the problem is needed to further design development. Methodology for furthering the technology along with the use of advanced fiber architectures to improve the thermal-structural response is explored in the current work. Thermal and structural finite element analyses are conducted for several advanced fiber architectures of interest. A tailored thermal shock parameter for sharp orthotropic leading edges is identified for evaluating composite material systems. The use of the tailored thermal shock parameter has the potential to eliminate the need for detailed thermal-structural finite element analyses for initial screening of material systems being considered for a leading edge component.

Human Response to Simulated Low-Intensity Sonic Booms

NASA Technical Reports Server (NTRS)

Sullivan, Brenda M.

2004-01-01

NASA's High Speed Research (HSR ) program in the 1990s was intended to develop a technology base for a future High-Speed Civil Transport (HSCT). As part of this program, the NASA Langley Research Center sonic boom simulator (SBS) was built and used for a series of tests on subjective response to sonic booms. At the end of the HSR program, an HSCT was deemed impractical, but since then interest in supersonic flight has reawakened, this time focusing on a smaller aircraft suitable for a business jet. To respond to this interest, the Langley sonic boom simulator has been refurbished. The upgraded computer-controlled playback system is based on an SGI O2 computer, in place of the previous DEC MicroVAX. As the frequency response of the booth is not flat, an equalization filter is required. Because of the changes made during the renovation (new loudspeakers), the previous equalization filter no longer performed as well as before, so a new equalization filter has been designed. Booms to be presented in the booth are preprocessed using the filter. When the preprocessed signals are presented into the booth and measured with a microphone, the results are very similar to the intended shapes. Signals with short rise times and sharp "corners" are observed to have a small amount of "ringing" in the response. During the HSR program a considerable number of subjective tests were completed in the SBS. A summary of that research is given in Leatherwood et al. (Individual reports are available at http://techreports.larc.nasa.gov/ltrs/ltrs.html.) Topics of study included shaped sonic booms, asymmetrical booms, realistic (recorded) boom waveforms, indoor and outdoor booms shapes, among other factors. One conclusion of that research was that a loudness metric, like the Stevens Perceived Level (PL), predicted human reaction much more accurately than overpressure or unweighted sound pressure level. Structural vibration and rattle were not included in these studies.

Switchable vanadium dioxide (VO2) metamaterials fabricated from tungsten doped vanadia-based colloidal nanocrystals

NASA Astrophysics Data System (ADS)

Paik, Taejong; Hong, Sung-Hoon; Gordon, Thomas; Gaulding, Ashley; Kagan, Cherie; Murray, Christopher

2013-03-01

We report the fabrication of thermochromic VO2-based metamaterials using solution-processable colloidal nanocrystals. Vanadium-based nanoparticles are prepared through a non-hydrolytic reaction, resulting in stable colloidal dispersions in solution. Thermochromic nanocrystalline VO2 thin-films are prepared via rapid thermal annealing of colloidal nanoparticles coated on a variety of substrates. Nanostructured VO2 can be patterned over large areas by nanoimprint lithography. Precise control of tungsten (W) doping concentration in colloidal nanoparticles enables tuning of the phase transition temperature of the nanocrystalline VO2 thin-films. W-doped VO2 films display a sharp temperature dependent phase transition, similar to the undoped VO2 film, but at lower temperatures tunable with the doping level. By sequential coating of doped VO2 with different doping concentrations, we fabricate ?smart? multi-layered VO2 films displaying multiple phase transition temperatures within a single structure, allowing for dynamic modulation of the metal-dielectric layered structure. The optical properties programmed into the layered structure are switchable with temperature, which provides additional degrees of freedom to design tunable optical metamaterials. This work is supported by the US Office of Naval Research Multidisciplinary University Research Initiative (MURI) program grant number ONR-N00014-10-1-0942.

The evolution of the Brewer-Dobson Circulation from 1960-2100 in simulations with the Chemistry Climate Model EMAC

NASA Astrophysics Data System (ADS)

Oberländer, Sophie; Langematz, Ulrike; Kubin, Anne; Abalichin, Janna; Meul, Stefanie; Jöckel, Patrick; Brühl, Christoph

2010-05-01

First results of research performed within the new DFG Research Unit Stratospheric Change and its Role for Climate Prediction (SHARP) will be presented. SHARP investigates past and future changes in stratospheric dynamics and composition to improve the understanding of global climate change and the accuracy of climate change predictions. SHARP combines the efforts of eight German research institutes and expertise in state-of-the-art climate modelling and observations. Within the scope of the scientific sub-project SHARP-BDC (Brewer-Dobson-Circulation) the past and future evolution of the BDC in an atmosphere with changing composition will be analysed. Radiosonde data show an annual mean cooling of the tropical lower stratosphere over the past few decades (Thompson and Solomon, 2005). Several independent model simulations indicate an acceleration of the BDC due to higher greenhouse gas (GHG) concentrations with direct impact on the exchange of air masses between the troposphere and stratosphere (e.g., Butchart et al, 2006). In contrast, from balloon-born measurements no significant acceleration in the BDC could be identified (Engel et al, 2008). This disagreement between observations and model analyses motivates further studies. For the future, expected changes in planetary wave generation and propagation in an atmosphere with increasing GHG concentrations are a major source of uncertainty for predicting future levels of stratospheric composition. To analyse and interpret the past and future evolution of the BDC, results from a transient multi-decadal simulation with the Chemistry-Climate Model (CCM) EMAC will be presented. The model has been integrated from 1960 to 2100 following the SCN2d scenario recommendations of the SPARC CCMVal initiative for the temporal evolution of GHGs, ozone depleting substances and sea surface temperatures as well as sea ice. The role of increasing GHG concentrations for the BDC will be assessed by comparing the SCN2d-results with a ‘non-climate change' (NCC) simulation, in which greenhouse gases have been kept fixed at their 1960 concentrations.

Course Level and the Relationship between Research Productivity and Teaching Effectiveness

ERIC Educational Resources Information Center

Arnold, Ivo J. M.

2008-01-01

The author examines the relationship between research productivity and teaching effectiveness using data from the Erasmus School of Economics. The initial findings indicate a positive overall relationship between the variables. A more detailed analysis reveals a sharp reversal in the nature of the relationship. Although the relationship is…

75 FR 65657 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-International SAE...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-26

..., pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et...; Clinical Data, Inc., Newton, MA; and Merck Sharp & Dohme Corp., Rahway, NJ, has been added as parties to...

The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs.

PubMed

Arieti, Fabiana; Gabus, Caroline; Tambalo, Margherita; Huet, Tiphaine; Round, Adam; Thore, Stéphane

2014-06-01

The Split Ends (SPEN) protein was originally discovered in Drosophila in the late 1990s. Since then, homologous proteins have been identified in eukaryotic species ranging from plants to humans. Every family member contains three predicted RNA recognition motifs (RRMs) in the N-terminal region of the protein. We have determined the crystal structure of the region of the human SPEN homolog that contains these RRMs-the SMRT/HDAC1 Associated Repressor Protein (SHARP), at 2.0 Å resolution. SHARP is a co-regulator of the nuclear receptors. We demonstrate that two of the three RRMs, namely RRM3 and RRM4, interact via a highly conserved interface. Furthermore, we show that the RRM3-RRM4 block is the main platform mediating the stable association with the H12-H13 substructure found in the steroid receptor RNA activator (SRA), a long, non-coding RNA previously shown to play a crucial role in nuclear receptor transcriptional regulation. We determine that SHARP association with SRA relies on both single- and double-stranded RNA sequences. The crystal structure of the SHARP-RRM fragment, together with the associated RNA-binding studies, extend the repertoire of nucleic acid binding properties of RRM domains suggesting a new hypothesis for a better understanding of SPEN protein functions. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Rerouting Success: Several Academic Pathways Programs Are Fueling Reform at Community Colleges

ERIC Educational Resources Information Center

Woods, Bob

2015-01-01

"Completion" has become the rallying cry at community colleges. As the 21st century unfolds, the earlier emphasis on guaranteeing greater access to a postsecondary education has evolved into a sharp focus on student success. Whether that means earning a workforcerelated certificate or an associate degree transferable to a four-year…

Closed-loop separation control over a sharp edge ramp using genetic programming

NASA Astrophysics Data System (ADS)

Debien, Antoine; von Krbek, Kai A. F. F.; Mazellier, Nicolas; Duriez, Thomas; Cordier, Laurent; Noack, Bernd R.; Abel, Markus W.; Kourta, Azeddine

2016-03-01

We experimentally perform open and closed-loop control of a separating turbulent boundary layer downstream from a sharp edge ramp. The turbulent boundary layer just above the separation point has a Reynolds number Re_{θ }≈ 3500 based on momentum thickness. The goal of the control is to mitigate separation and early re-attachment. The forcing employs a spanwise array of active vortex generators. The flow state is monitored with skin-friction sensors downstream of the actuators. The feedback control law is obtained using model-free genetic programming control (GPC) (Gautier et al. in J Fluid Mech 770:442-457, 2015). The resulting flow is assessed using the momentum coefficient, pressure distribution and skin friction over the ramp and stereo PIV. The PIV yields vector field statistics, e.g. shear layer growth, the back-flow area and vortex region. GPC is benchmarked against the best periodic forcing. While open-loop control achieves separation reduction by locking-on the shedding mode, GPC gives rise to similar benefits by accelerating the shear layer growth. Moreover, GPC uses less actuation energy.

Swedish austerity: benefits at risk.

PubMed

Carroll, E

1993-01-01

The Swedish welfare state is facing the greatest threat since its inception. Attacks stem from the country's sharp economic downturn since 1989 and the related currency crisis of September 1992. Politicians of the right and left have responded to the economic crisis by initiating cutbacks in social welfare programs and supporting policies that will lead to a massive transfer of income from working people to corporations. The focus on cutting social programs is misplaced. The Swedish economy flourished for decades with the network of social service programs in place; the welfare state cannot be blamed for economic problems that have only recently arisen.

Common ground, not a battle ground. Violence prevention at a detoxification facility.

PubMed

Adamson, Mary A; Vincent, Audrey A; Cundiff, Jeff

2009-08-01

This article evaluates the results of a workplace violence prevention program implemented in a Colorado detoxification facility. The program interventions are modeled after federal Occupational Safety and Health Administration guidelines and use theories from both nursing and criminology for philosophy and direction. Serving as its own control, the detoxification facility shares data measured over a 4-year period, demonstrating a sharp decline in assault rates after program implementation. The importance of administrative controls, environmental adjustments, recordkeeping and evaluation, and education and training are emphasized as key components of success. Copyright (c) 2009, SLACK Incorporated.

Screening and treatment of asymptomatic bacteriuria in pregnancy prevent pyelonephritis.

PubMed

Gratacós, E; Torres, P J; Vila, J; Alonso, P L; Cararach, V

1994-06-01

Although asymptomatic bacteriuria during pregnancy is associated with an increased risk of developing pyelonephritis, the effectiveness of screening programs to reduce this risk is controversial. A sharp reduction in the annual incidence of pyelonephritis (1.8% to 0.6%, P < .001) occurred after the introduction of a program to screen and treat asymptomatic bacteriuria among pregnant women followed at a large teaching hospital. The data provide retrospective and prospective evidence that screening and treatment programs for asymptomatic bacteriuria during pregnancy reduce the risk of pyelonephritis in a population with a moderate to high prevalence of bacteriuria.

FY04 Engineering Technology Reports Laboratory Directed Research and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharpe, R M

2005-01-27

This report summarizes the science and technology research and development efforts in Lawrence Livermore National Laboratory's Engineering Directorate for FY2004, and exemplifies Engineering's more than 50-year history of developing the technologies needed to support the Laboratory's missions. Engineering has been a partner in every major program and project at the Laboratory throughout its existence and has prepared for this role with a skilled workforce and the technical resources developed through venues like the Laboratory Directed Research and Development Program (LDRD). This accomplishment is well summarized by Engineering's mission: ''Enable program success today and ensure the Laboratory's vitality tomorrow''. Engineering's investmentmore » in technologies is carried out through two programs, the ''Tech Base'' program and the LDRD program. LDRD is the vehicle for creating those technologies and competencies that are cutting edge. These require a significant level of research or contain some unknown that needs to be fully understood. Tech Base is used to apply technologies to a Laboratory need. The term commonly used for Tech Base projects is ''reduction to practice''. Therefore, the LDRD report covered here has a strong research emphasis. Areas that are presented all fall into those needed to accomplish our mission. For FY2004, Engineering's LDRD projects were focused on mesoscale target fabrication and characterization, development of engineering computational capability, material studies and modeling, remote sensing and communications, and microtechnology and nanotechnology for national security applications. Engineering's five Centers, in partnership with the Division Leaders and Department Heads, are responsible for guiding the long-term science and technology investments for the Directorate. The Centers represent technologies that have been identified as critical for the present and future work of the Laboratory, and are chartered to develop their respective areas. Their LDRD projects are the key resources to attain this competency, and, as such, nearly all of Engineering's portfolio falls under one of the five Centers. The Centers and their Directors are: (1) Center for Computational Engineering: Robert M. Sharpe; (2) Center for Microtechnology and Nanotechnology: Raymond P. Mariella, Jr.; (3) Center for Nondestructive Characterization: Harry E. Martz, Jr.; (4) Center for Precision Engineering: Keith Carlisle; and (5) Center for Complex Distributed Systems: Gregory J. Suski, Acting Director.« less

Exploring Reticence in Research Methods: The Experience of Studying Psychological Research Methods in Higher Education

ERIC Educational Resources Information Center

Kingsley, Barbara E.; Robertson, Julia M.

2017-01-01

As a fundamental element of any psychology degree, the teaching and learning of research methods is repeatedly brought into sharp focus, and it is often regarded as a real challenge by undergraduate students. The reasons for this are complex, but frequently attributed to an aversion of maths. To gain a more detailed understanding of students'…

Postoperative pain and neuropathy after caesarean operation featuring blunt or sharp opening of the fascia: a randomised, parallel group, double-blind study.

PubMed

Yazici Yilmaz, Fatma; Aydogan Mathyk, Begum; Yildiz, Serhat; Yenigul, Nefise Nazli; Saglam, Ceren

2018-03-21

The purpose of this study was to compare postoperative pain and neuropathy after primary caesarean sections with either blunt or sharp fascial expansions. A total of 123 women undergoing primary caesarean sections were included in the study. The sharp group had 61 patients, and the blunt group had 62. In the sharp group, the fascia was incised sharply and extended using scissors. In blunt group, the fascia was bluntly opened by lateral finger-pulling. The primary outcome was postoperative pain. The long-term chronic pain scores were significantly lower in the blunt group during mobilisation (p = .012 and p = .022). Neuropathy was significantly more prevalent in the sharp group at both 1 and 3 months postoperatively (p = .043 and p = .016, respectively). The odds ratio (OR) and 95%CI for postoperative neuropathy at 1 and 3 months were as follows; OR 3.71, 95%CI 0.97-14.24 and OR 5.67, 95%CI 1.18-27.08, respectively. The OR for postoperative pain after 3 months was 3.26 (95%CI 1.09-9.73). The prevelance of postsurgical neuropathy and chronic pain at 3 months were significantly lower in the blunt group. Blunt fascial opening reduces the complication rate of postoperative pain and neuropathy after caesarean sections. Impact statement What is already known on this subject? The anatomic relationship of the abdominal fascia and the anterior abdominal wall nerves is a known fact. The fascia during caesarean sections can be opened by either a sharp or blunt extension. Data on the isolated impact of different fascial incisions on postoperative pain is limited. What do the results of this study add? The postoperative pain scores on the incision area are lower in the bluntly opened group compared to the sharp fascial incision group. By extending the fascia bluntly, a decrease in trauma and damage to nerves was observed. What are the implications of these findings for clinical practice and/or future research? The lateral extension of the fascia during caesarean sections must be done cautiously to prevent temporary damage to nerves and vessels. The blunt opening of the fascia by lateral finger pulling might be a preferred method over the sharp approach that uses scissors. We included only primary caesarean cases, however, comparisons of blunt and sharp fascial incisions in patients with more than one abdominal surgery should be explored in future studies.

Selection Criteria for New Materials For Thermoelectric Applications

NASA Astrophysics Data System (ADS)

Tritt, T. M.

1997-11-01

Recently there has been renewed interest in materials for thermoelectric refrigeration and power generation applications.(Terry M. Tritt, Science, 272, 1276, 1996),(G. Mahan, B. Sales and J. Sharp, Physics Today, March 50, 42, 1997) We have established a multidisciplinary program within the Physics Department and in collaboration with the Chemistry Department at Clemson University. The focus of our research utilizes a broad understanding of solid state physics coupled with solid state chemistry to synthesize and fully characterize promising materials for their potential as the "next generation" thermoelectric materials. An introduction to thermoelectric materials and the criteria for their selection and potential for applications will be given. To be promising as a thermoelectric material, a material must have a high Seebeck coefficient, α, high electrical conductivity, σ, and a low thermal conductivity, λ. These parameters go into the materials dimensionless figure of merit ZT = α^2σT/λ. We will discuss these parameters in relation to this materials performance as a potential thermoelectric material. We will also discuss some of the materials that are currently being investigated in the program at Clemson University.

Improving medium-range ensemble streamflow forecasts through statistical post-processing

NASA Astrophysics Data System (ADS)

Mendoza, Pablo; Wood, Andy; Clark, Elizabeth; Nijssen, Bart; Clark, Martyn; Ramos, Maria-Helena; Nowak, Kenneth; Arnold, Jeffrey

2017-04-01

Probabilistic hydrologic forecasts are a powerful source of information for decision-making in water resources operations. A common approach is the hydrologic model-based generation of streamflow forecast ensembles, which can be implemented to account for different sources of uncertainties - e.g., from initial hydrologic conditions (IHCs), weather forecasts, and hydrologic model structure and parameters. In practice, hydrologic ensemble forecasts typically have biases and spread errors stemming from errors in the aforementioned elements, resulting in a degradation of probabilistic properties. In this work, we compare several statistical post-processing techniques applied to medium-range ensemble streamflow forecasts obtained with the System for Hydromet Applications, Research and Prediction (SHARP). SHARP is a fully automated prediction system for the assessment and demonstration of short-term to seasonal streamflow forecasting applications, developed by the National Center for Atmospheric Research, University of Washington, U.S. Army Corps of Engineers, and U.S. Bureau of Reclamation. The suite of post-processing techniques includes linear blending, quantile mapping, extended logistic regression, quantile regression, ensemble analogs, and the generalized linear model post-processor (GLMPP). We assess and compare these techniques using multi-year hindcasts in several river basins in the western US. This presentation discusses preliminary findings about the effectiveness of the techniques for improving probabilistic skill, reliability, discrimination, sharpness and resolution.

Philosophical Challenges for Researchers at the Interface between Neuroscience and Education

ERIC Educational Resources Information Center

Howard-Jones, Paul

2008-01-01

This article examines how discussions around the new interdisciplinary research area combining neuroscience and education have brought into sharp relief differences in the philosophies of learning in these two areas. It considers the difficulties faced by those working at the interface between these two areas and, in particular, it focuses on the…

Conceptions of the Principles and Practices of Effective Staff Development: A Caribbean Perspective.

ERIC Educational Resources Information Center

Clarke, Desmond C.

This research focused on the perceptions of primary teachers (N=337) in the Eastern Caribbean concerning the principles, activities, and delivery strategies that would inform staff development efforts to meet their professional needs. In particular, the research sought to establish whether, given the sharp contextual differences between the…

Two-Dimensional Grids About Airfoils and Other Shapes

NASA Technical Reports Server (NTRS)

Sorenson, R.

1982-01-01

GRAPE computer program generates two-dimensional finite-difference grids about airfoils and other shapes by use of Poisson differential equation. GRAPE can be used with any boundary shape, even one specified by tabulated points and including limited number of sharp corners. Numerically stable and computationally fast, GRAPE provides aerodynamic analyst with efficient and consistant means of grid generation.

An Empirical Study about the Critical Factors Affecting MIS Students' Job Opportunities

ERIC Educational Resources Information Center

Fang, Xiang; Lee, Sooun

2005-01-01

For the first time in many years, Management Information Systems (MIS) students and faculty are seeking ways to improve full-time job placement for program graduates. Due to sharp IT budget cuts, the slowing economy, and outsourcing, job opportunities for MIS graduates have become scarcer than ever before. In addition to achieving good academic…

Argo Development Program.

DTIC Science & Technology

1986-06-01

nonlinear form and account for uncertainties in model parameters, structural simplifications of the model, and disturbances. This technique summarizes...SHARPS system. *The take into account the coupling between axes two curves are nearly identical, except that the without becoming unwieldy. The low...are mainly caused by errors and control errors and accounts for the bandwidth limitations and the simulated current. observed offsets. The overshoot

Needlestick and Sharp Instruments Injuries among Brazilian Dentistry Students

PubMed Central

Fernandes, Liege Helena Freitas; Nunes, Wanúbia Barbosa; Silva, Larissa Costa; Wanderley, Rayssa Lucena; Barros, Criseuda Maria Benício; Cavalcanti, Alessandro Leite

2017-01-01

Background: The occurrence of occupational accidents is common among students and dentists. The present study is aimed to evaluate the prevalence and characteristics of needlestick and sharp instrument injuries among dentistry students. Materials and Methods: A documentary research was carried out with data being obtained from the analysis of 137 medical records of injuries caused by needlestick and sharp instruments occurring in the period from 2012 to 2016 and were analyzed regarding the characteristics of the victim (gender and age) and the accident (year, time, environment, and time interval between exposure and search for care). Data were organized in the Statistical Package for Social Sciences software version 18 and were presented through descriptive statistics. Results: The occurrence of accidents was high (43.1%), with the predominance of female victims (66.1%) and aged up to 23 years (55.9%). The majority of events occurred in the afternoon (54.4%), in the clinical setting (70.7%), and in 75% of the cases, the search for care occurred within 2 h after exposure. Conclusion: Accidents with needlestick and sharp instruments have high frequency and involve mainly female students. They are more common in the afternoon and in the clinical setting and the time interval was between exposure and the search for care complied with recommendations of the Brazilian legislation. PMID:28566861

Analysis of sharpness increase by image noise

NASA Astrophysics Data System (ADS)

Kurihara, Takehito; Aoki, Naokazu; Kobayashi, Hiroyuki

2009-02-01

Motivated by the reported increase in sharpness by image noise, we investigated how noise affects sharpness perception. We first used natural images of tree bark with different amounts of noise to see whether noise enhances sharpness. Although the result showed sharpness decreased as noise amount increased, some observers seemed to perceive more sharpness with increasing noise, while the others did not. We next used 1D and 2D uni-frequency patterns as stimuli in an attempt to reduce such variability in the judgment. The result showed, for higher frequency stimuli, sharpness decreased as the noise amount increased, while sharpness of the lower frequency stimuli increased at a certain noise level. From this result, we thought image noise might reduce sharpness at edges, but be able to improve sharpness of lower frequency component or texture in image. To prove this prediction, we experimented again with the natural image used in the first experiment. Stimuli were made by applying noise separately to edge or to texture part of the image. The result showed noise, when added to edge region, only decreased sharpness, whereas when added to texture, could improve sharpness. We think it is the interaction between noise and texture that sharpens image.

Comparison of healing rate in diabetes-related foot ulcers with low frequency ultrasonic debridement versus non-surgical sharps debridement: a randomised trial protocol

PubMed Central

2014-01-01

Background Foot ulceration has been reported as the leading cause of hospital admission and amputation in individuals with diabetes. Diabetes-related foot ulcers require multidisciplinary management and best practice care, including debridement, offloading, dressings, management of infection, modified footwear and management of extrinsic factors. Ulcer debridement is a commonly applied management approach involving removal of non-viable tissue from the ulcer bed. Different methods of debridement have been reported in the literature including autolytic debridement via moist wound healing, mechanical debridement utilising wet to dry dressings, theatre based sharps debridement, biological debridement, non-surgical sharps debridement and newer technology such as low frequency ultrasonic debridement. Methods People with diabetes and a foot ulcer, referred to and treated by the Podiatry Department at Monash Health and who meet the inclusion criteria will be invited to participate in this randomised controlled trial. Participants will be randomly and equally allocated to either the non-surgical sharps debridement (control) or low frequency ultrasonic debridement (intervention) group (n = 322 ulcers/n = 108 participants). Where participants have more than one ulcer, only the participant will be randomised, not the ulcer. An investigator not involved in participant recruitment or assessment will be responsible for preparing the random allocation sequence and envelopes. Each participant will receive weekly treatment for six months including best practice podiatric management. Each ulcer will be measured on a weekly basis by calculating total area in centimetres squared. Measurement will be undertaken by a trained research assistant to ensure outcomes are blinded from the treating podiatrist. Another member of the research team will assess the final primary outcome. Discussion The primary aim of this study is to compare healing rates for diabetes-related foot ulcers using non-surgical sharps debridement versus low frequency ultrasonic debridement over a six month period. The primary outcome measure for this study is the proportion of ulcers healed by the six month follow-up period. Secondary outcomes will include a quality of life measure, assessment of pain and health care resource use between the two treatment modalities. Trial registration Australian New Zealand Clinical Trial Registry: ACTRN12612000490875. PMID:24423411

The High Cost of Complexity in Experimental Design and Data Analysis: Type I and Type II Error Rates in Multiway ANOVA.

ERIC Educational Resources Information Center

Smith, Rachel A.; Levine, Timothy R.; Lachlan, Kenneth A.; Fediuk, Thomas A.

2002-01-01

Notes that the availability of statistical software packages has led to a sharp increase in use of complex research designs and complex statistical analyses in communication research. Reports a series of Monte Carlo simulations which demonstrate that this complexity may come at a heavier cost than many communication researchers realize. Warns…

Study of hydrodynamic characteristics of a Sharp Eagle wave energy converter

NASA Astrophysics Data System (ADS)

Zhang, Ya-qun; Sheng, Song-wei; You, Ya-ge; Huang, Zhen-xin; Wang, Wen-sheng

2017-06-01

According to Newton's Second Law and the microwave theory, mechanical analysis of multiple buoys which form Sharp Eagle wave energy converter (WEC) is carried out. The movements of every buoy in three modes couple each other when they are affected with incident waves. Based on the above, mechanical models of the WEC are established, which are concerned with fluid forces, damping forces, hinge forces, and so on. Hydrodynamic parameters of one buoy are obtained by taking the other moving buoy as boundary conditions. Then, by taking those hydrodynamic parameters into the mechanical models, the optimum external damping and optimal capture width ratio are calculated out. Under the condition of the optimum external damping, a plenty of data are obtained, such as the displacements amplitude of each buoy in three modes (sway, heave, pitch), damping forces, hinge forces, and speed of the hydraulic cylinder. Research results provide theoretical references and basis for Sharp Eagle WECs in the design and manufacture.

Brown CA et al 2016 Dataset

EPA Pesticide Factsheets

This dataset contains the research described in the following publication:Brown, C.A., D. Sharp, and T. Mochon Collura. 2016. Effect of Climate Change on Water Temperature and Attainment of Water Temperature Criteria in the Yaquina Estuary, Oregon (USA). Estuarine, Coastal and Shelf Science. 169:136-146, doi: 10.1016/j.ecss.2015.11.006.This dataset is associated with the following publication:Brown , C., D. Sharp, and T. MochonCollura. Effect of Climate Change on Water Temperature and Attainment of Water Temperature Criteria in the Yaquina Estuary, Oregon (USA). ESTUARINE, COASTAL AND SHELF SCIENCE. Elsevier Science Ltd, New York, NY, USA, 169: 136-146, (2016).

Versatile and declarative dynamic programming using pair algebras.

PubMed

Steffen, Peter; Giegerich, Robert

2005-09-12

Dynamic programming is a widely used programming technique in bioinformatics. In sharp contrast to the simplicity of textbook examples, implementing a dynamic programming algorithm for a novel and non-trivial application is a tedious and error prone task. The algebraic dynamic programming approach seeks to alleviate this situation by clearly separating the dynamic programming recurrences and scoring schemes. Based on this programming style, we introduce a generic product operation of scoring schemes. This leads to a remarkable variety of applications, allowing us to achieve optimizations under multiple objective functions, alternative solutions and backtracing, holistic search space analysis, ambiguity checking, and more, without additional programming effort. We demonstrate the method on several applications for RNA secondary structure prediction. The product operation as introduced here adds a significant amount of flexibility to dynamic programming. It provides a versatile testbed for the development of new algorithmic ideas, which can immediately be put to practice.

Pocket computers: a new aid to nutritional support.

PubMed Central

Colley, C M; Fleck, A; Howard, J P

1985-01-01

A program has been written to run on a pocket computer (Sharp PC-1500) that can be used at the bedside to predict the nutritional requirements of patients with a wide range of clinical conditions. The predictions of the program showed good correlation with measured values for energy and nitrogen requirements. The program was used, with good results, in the management of over 100 patients needing nutritional support. The calculation of nutritional requirements for each patient individually facilitates more appropriate treatment and may also produce financial savings when compared with administration of a standard feeding regimen to all patients. Images FIG 1 PMID:3922512

Time accurate application of the MacCormack 2-4 scheme on massively parallel computers

NASA Technical Reports Server (NTRS)

Hudson, Dale A.; Long, Lyle N.

1995-01-01

Many recent computational efforts in turbulence and acoustics research have used higher order numerical algorithms. One popular method has been the explicit MacCormack 2-4 scheme. The MacCormack 2-4 scheme is second order accurate in time and fourth order accurate in space, and is stable for CFL's below 2/3. Current research has shown that the method can give accurate results but does exhibit significant Gibbs phenomena at sharp discontinuities. The impact of adding Jameson type second, third, and fourth order artificial viscosity was examined here. Category 2 problems, the nonlinear traveling wave and the Riemann problem, were computed using a CFL number of 0.25. This research has found that dispersion errors can be significantly reduced or nearly eliminated by using a combination of second and third order terms in the damping. Use of second and fourth order terms reduced the magnitude of dispersion errors but not as effectively as the second and third order combination. The program was coded using Thinking Machine's CM Fortran, a variant of Fortran 90/High Performance Fortran, and was executed on a 2K CM-200. Simple extrapolation boundary conditions were used for both problems.

Development of a Flush Airdata Sensing System on a Sharp-Nosed Vehicle for Flight at Mach 3 to 8

NASA Technical Reports Server (NTRS)

Davis, Mark C.; Pahle, Joseph W.; White, John Terry; Marshall, Laurie A.; Mashburn, Michael J.; Franks, Rick

2000-01-01

NASA Dryden Flight Research Center has developed a flush airdata sensing (FADS) system on a sharp-nosed, wedge-shaped vehicle. This paper details the design and calibration of a real-time angle-of-attack estimation scheme developed to meet the onboard airdata measurement requirements for a research vehicle equipped with a supersonic-combustion ramjet engine. The FADS system has been designed to perform in flights at Mach 3-8 and at -6 deg - 12 deg angle of attack. The description of the FADS architecture includes port layout, pneumatic design, and hardware integration. Predictive models of static and dynamic performance are compared with wind-tunnel results across the Mach and angle-of-attack range. Results indicate that static angle-of-attack accuracy and pneumatic lag can be adequately characterized and incorporated into a real-time algorithm.

[Herpetic encephalitis: a clinical case].

PubMed

Dryhant, L P; Sereda, V H; Kushpiĭ, O V; Tkachenko, V V; Kravchuk, N A; Inhula, N I; Sizina, A V; Sachko, Iu Iu; Andrusenko, A S; Tytenko, Iu I; Babirad, A M

2012-01-01

An example of diagnostics and treatment of patient is in-process made with herpetic encephalitis. It is well-proven in researches, that a herpetic encephalitis is 11.5% among sharp encephalitises. Morbidity is sporadic, some researchers specify on an increase its spring. An infection can be passed tiny and pin a way. Seasonal vibrations are not incident to the herpetic encephalitis. Two peaks of morbidity are on 5-30 years and age more senior 50 years. More than in 95% cases the virus of simple herpes of type serves as an exciter of herpetic encephalitis 1. A characteristic triad of herpetic encephalitis is the sharp feverish beginning, development of cramps of dzheksonovskogo type and violation of consciousness, developing usually after a brief respirator infection. Sometimes sudden development of cramps and loss of consciousness is preceded a fever. Example of such development of disease is made an in our work.

Development of a Flush Airdata Sensing System on a Sharp-Nosed Vehicle for Flight at Mach 3 to 8

NASA Technical Reports Server (NTRS)

Davis, Mark C.; Pahle, Joseph W.; White, John Terry; Marshall, Laurie A.; Mashburn, Michael J.; Franks, Rick

2000-01-01

NASA Dryden Flight Research Center has developed a flush airdata sensing (FADS) system on a sharp-nosed, wedge-shaped vehicle. This paper details the design and calibration of a real-time angle-of-attack estimation scheme developed to meet the onboard airdata measurement requirements for a research vehicle equipped with a supersonic-combustion ramjet engine. The FADS system has been designed to perform in flights at speeds between Mach 3 and Mach 8 and at angles of attack between -6 deg. and 12 deg. The description of the FADS architecture includes port layout, pneumatic design, and hardware integration. Predictive models of static and dynamic performance are compared with wind-tunnel results across the Mach and angle-of-attack range. Results indicate that static angle-of-attack accuracy and pneumatic lag can be adequately characterized and incorporated into a real-time algorithm.

The Impact of Changing Funding and Authority Relationships on Scientific Innovations

ERIC Educational Resources Information Center

Whitley, Richard; Gläser, Jochen; Laudel, Grit

2018-01-01

The past three decades have witnessed a sharp reduction in the rate of growth of public research funding, and sometimes an actual decline in its level. In many countries, this decline has been accompanied by substantial changes in the ways that such funding has been allocated and monitored. In addition, the institutions governing how research is…

Nursing Faculty Experiences of Virtual Learning Environments for Teaching Clinical Reasoning

ERIC Educational Resources Information Center

Zacharzuk-Marciano, Tara

2017-01-01

Nurses need sharp, clinical reasoning skills to respond to critical situations and to be successful at work in a complex and challenging healthcare system. While past research has focused on using virtual learning environments to teach clinical reasoning, there has been limited research on the experiences of nursing faculty and there is a need for…

The Use of Theory in School Effectiveness Research Revisited

ERIC Educational Resources Information Center

Scheerens, Jaap

2013-01-01

From an international review of 109 school effectiveness research studies, only 6 could be seen as theory driven. As the border between substantive conceptual models of educational effectiveness and theory-based models is not always very sharp, this number might be increased to 11 by including those studies that are based on models that make…

Theory of space charge limited currents in films and nanowires with dopants

NASA Astrophysics Data System (ADS)

Zhang, Xiaoguang; Pantelides, Sokrates

2015-03-01

We show that proper description of the space charge limited currents (SCLC) in a homogeneous bulk material must account fully for the effect of the dopants and the interplay between dopants and traps. The sharp rise in the current at the trap-filled-limit (TFL) is partially mitigated by the dopant energy levels and the Frenkel effect, namely the lowering of the ionization energy by the electric field, which is screened by the free carriers. In nanowires, lack of effective screening causes the trap occupation at small biases to reach a high level comparable to the TFL in bulk. This explains the high current density in SCLCs observed in nanowires. This work is supported by the LDRD program at ORNL. Portion of this research was conducted at the Center for Nanophase Materials Sciences, which is a DOE Office of Science User Facility.

EHS Open House: Learning Lab and Life Safety | Poster

Cancer.gov

Attendees of the Environment, Health, and Safety Program’s (EHS’) Open House had a chance to learn self-defense techniques, as well as visit with vendors demonstrating the latest trends in laboratory safety. “Working with sharps in labs is inherently dangerous, so EHS proactively focused on featuring equipment that would promote safer techniques,” said Siobhan Tierney, program manager, EHS.

SIGMA Release v1.2 - Capabilities, Enhancements and Fixes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahadevan, Vijay; Grindeanu, Iulian R.; Ray, Navamita

In this report, we present details on SIGMA toolkit along with its component structure, capabilities, and feature additions in FY15, release cycles, and continuous integration process. These software processes along with updated documentation are imperative to successfully integrate and utilize in several applications including the SHARP coupled analysis toolkit for reactor core systems funded under the NEAMS DOE-NE program.

EHS Open House: Learning Lab and Life Safety | Poster

Cancer.gov

Attendees of the Environment, Health, and Safety Program’s (EHS’) Open House had a chance to learn self-defense techniques, as well as visit with vendors demonstrating the latest trends in laboratory safety. “Working with sharps in labs is inherently dangerous, so EHS proactively focused on featuring equipment that would promote safer techniques,” said Siobhan Tierney, program

Partnership to Enhance Diversity in Marine Geosciences: Holocene Climate and Anthorpogenic Changes from Long Island Sound, NY

NASA Astrophysics Data System (ADS)

McHugh, C. M.; Cormier, M.; Marchese, P.; Zheng, Y.; Kohfeld, K.

2006-12-01

This NSF-funded program developed an oceanographic field experience coupled to a strong curriculum and one-on-one mentoring of individual research projects, as a means to increase diversity in the geosciences. The working hypothesis is that New York City students will be attracted to geosciences through an integrated field and research experience that familiarizes them with their environment. As part of this program, multidisciplinary investigations of Long Island Sound were conducted from the R/V Hugh Sharp, part of the University-National Oceanographic Laboratory System (UNOLS) fleet, for one-week during June 2006. Nine students from underrepresented groups in the geosciences (native Americans, Hispanics, and African- Americans) and five investigators from various institutions specializing in marine geophysics, geology, geochemistry, biology, and physical oceanography participate in this project. The expedition introduced the students to a variety of oceanographic techniques, including multibeam bathymetric mapping, high-resolution subbottom profiling, side scan sonar, sediment, water, and biological sampling, and current profiling. The collected dataset is now analyzed by the students to extract the late Quaternary history of Long Island Sound and to assess the impact of anthropogenic activities in the sediments, waters, and ecosystems. 85 % of the student participants have declared either a geoscience and/or environmental science major with concentrations in biology and geosciences. Recruiting for the program relied on partnerships with: 1) Alliance for Minority Participation (AMP) Program of the City University of New York (CUNY). A program supported by the National Science Foundation and in which Queens College (QC) and CUNY participate; 2) the Search for Education, Elevation, and Knowledge Program (SEEK) in place at Queens College. A program designed to provide educational opportunities for academically motivated students who need substantial financial assistance to attend college; and 3) through our regular teaching schedule for non-geoscience majors. The PIs work at four different institutions from NY metropolitan area: 1) Queens College (QC) from the City University of New York (CUNY.); 2) Queensborough Community College (CUNY), a minority serving college; 3) Lehman College (CUNY), a minority serving college; and 4) Lamont-Doherty Earth Observatory (LDEO), a world-class earth science research institution. External financial support for the program has been secured through the City University of New York Graduate Center through a MAGNET fellowship, Minorities Striving and Pursuing Higher Degrees of Success in Earth Systems Science Professional Development Program 2006, through two industry grants (Entergy Co. and NRG Energy), and in the future, through the availability at competitive rates of local research vessels for day- trips. We anticipate that the program will further gain momentum through partnerships with other City University of New York senior and community colleges, and thanks to word of mouth from those students who participated in the program.

Sharps Injuries and Other Blood and Body Fluid Exposures Among Home Health Care Nurses and Aides

PubMed Central

Markkanen, Pia K.; Galligan, Catherine J.; Kriebel, David; Chalupka, Stephanie M.; Kim, Hyun; Gore, Rebecca J.; Sama, Susan R.; Laramie, Angela K.; Davis, Letitia

2009-01-01

Objectives. We quantified risks of sharp medical device (sharps) injuries and other blood and body fluid exposures among home health care nurses and aides, identified risk factors, assessed the use of sharps with safety features, and evaluated underreporting in workplace-based surveillance. Methods. We conducted a questionnaire survey and workplace-based surveillance, collaborating with 9 home health care agencies and 2 labor unions from 2006 to 2007. Results. Approximately 35% of nurses and 6.4% of aides had experienced at least 1 sharps injury during their home health care career; corresponding figures for other blood and body fluid exposures were 15.1% and 6.7%, respectively. Annual sharps injuries incidence rates were 5.1 per 100 full-time equivalent (FTE) nurses and 1.0 per 100 FTE aides. Medical procedures contributing to sharps injuries were injecting medications, administering fingersticks and heelsticks, and drawing blood. Other contributing factors were sharps disposal, contact with waste, and patient handling. Sharps with safety features frequently were not used. Underreporting of sharps injuries to the workplace-based surveillance system was estimated to be about 50%. Conclusions. Sharps injuries and other blood and body fluid exposures are serious hazards for home health care nurses and aides. Improvements in hazard intervention are needed. PMID:19890177

Needlestick and Sharps Injuries in Dermatologic Surgery: A Review of Preventative Techniques and Post-exposure Protocols

PubMed Central

Monroe, Holly; Orengo, Ida; Rosen, Theodore

2016-01-01

Background: Needlestickand sharps injuries are the leading causes of morbidity in the dermatologicfield. Among medical specialties, surgeons and dermatologists have the highest rates of needlestickand sharps injuries.The high rates of needlestickand sharps injuries in dermatology not only apply to physicians, but also to nurses, physician assistants, and technicians in the demnatologic field. Needlestickand sharps injuries are of great concern due to the monetary, opportunity, social, and emotional costs associated with their occurrence. Objective: A review of preventative techniques and post-exposure protocols for the majortypes of sharps injuries encountered in dermatologic practice. Design: The terms “needle-stick injuryT’sharps injuryTdermatologic surgery? “post-exposure prophylaxis,”and “health-care associated injury” were used in combinations to search the PubMed database. Relevant studies were reviewed for validity and included. Results The authors discuss the major types of sharps injuries that occur in the dermatologic surgery setting and summarize preventative techniques with respect to each type of sharps injury.The authors also summarize and discuss relevant post-exposure protocols in the event of a sharps injury. Conclusion: The adoption of the discussed methods, techniques, practices, and attire can result in the elimination of the vast majority of dermatologic sharps injuries. PMID:27847548

Sharp and blunt force trauma concealment by thermal alteration in homicides: An in-vitro experiment for methodology and protocol development in forensic anthropological analysis of burnt bones.

PubMed

Macoveciuc, Ioana; Márquez-Grant, Nicholas; Horsfall, Ian; Zioupos, Peter

2017-06-01

Burning of human remains is one method used by perpetrators to conceal fatal trauma and expert opinions regarding the degree of skeletal evidence concealment are often disparate. This experiment aimed to reduce this incongruence in forensic anthropological interpretation of burned human remains and implicitly contribute to the development of research methodologies sufficiently robust to withstand forensic scrutiny in the courtroom. We have tested the influence of thermal alteration on pre-existing sharp and blunt trauma on twenty juvenile sheep radii in the laboratory using an automated impact testing system and an electric furnace. The testing conditions simulated a worst-case scenario where remains with pre-existing sharp or blunt trauma were exposed to burning with an intentional vehicular fire scenario in mind. All impact parameters as well as the burning conditions were based on those most commonly encountered in forensic cases and maintained constant throughout the experiment. The results have shown that signatures associated with sharp and blunt force trauma were not masked by heat exposure and highlights the potential for future standardization of fracture analysis in burned bone. Our results further emphasize the recommendation given by other experts on handling, processing and recording burned remains at the crime scene and mortuary. Copyright © 2017 Elsevier B.V. All rights reserved.

Towards a sharp-interface volume-of-fluid methodology for modeling evaporation

NASA Astrophysics Data System (ADS)

Pathak, Ashish; Raessi, Mehdi

2017-11-01

In modeling evaporation, the diffuse-interface (one-domain) formulation yields inaccurate results. Recent efforts approaching the problem via a sharp-interface (two-domain) formulation have shown significant improvements. The reasons behind their better performance are discussed in the present work. All available sharp-interface methods, however, exclusively employ the level-set. In the present work, we develop a sharp-interface evaporation model in a volume-of-fluid (VOF) framework in order to leverage its mass-conserving property as well as its ability to handle large topographical changes. We start with a critical review of the assumptions underlying the mathematical equations governing evaporation. For example, it is shown that the assumption of incompressibility can only be applied in special circumstances. The famous D2 law used for benchmarking is valid exclusively to steady-state test problems. Transient is present over significant lifetime of a micron-size droplet. Therefore, a 1D spherical fully transient model is developed to provide a benchmark transient solution. Finally, a 3D Cartesian Navier-Stokes evaporation solver is developed. Some preliminary validation test-cases are presented for static and moving drop evaporation. This material is based upon work supported by the Department of Energy, Office of Energy Efficiency and Renewable Energy and the Department of Defense, Tank and Automotive Research, Development, and Engineering Center, under Award Number DEEE0007292.

Emulation of anamorphic imaging on the SHARP extreme ultraviolet mask microscope

DOE PAGES

Benk, Markus P.; Wojdyla, Antoine; Chao, Weilun; ...

2016-07-12

The SHARP high-numerical aperture actinic reticle review project is a synchrotron-based, extreme ultraviolet (EUV) microscope dedicated to photomask research. SHARP emulates the illumination and imaging conditions of current EUV lithography scanners and those several generations into the future. An anamorphic imaging optic with increased mask-side numerical aperture (NA) in the horizontal and increased demagnification in the vertical direction has been proposed in this paper to overcome limitations of current multilayer coatings and extend EUV lithography beyond 0.33 NA. Zoneplate lenses with an anamorphic 4×/8× NA of 0.55 are fabricated and installed in the SHARP microscope to emulate anamorphic imaging. SHARP’smore » Fourier synthesis illuminator with a range of angles exceeding the collected solid angle of the newly designed elliptical zoneplates can produce arbitrary angular source spectra matched to anamorphic imaging. A target with anamorphic dense features down to 50-nm critical dimension is fabricated using 40 nm of nickel as the absorber. In a demonstration experiment, anamorphic imaging at 0.55 4×/8× NA and 6 deg central ray angle (CRA) is compared with conventional imaging at 0.5 4× NA and 8 deg CRA. A significant contrast loss in horizontal features is observed in the conventional images. Finally, the anamorphic images show the same image quality in the horizontal and vertical directions.« less

Emulation of anamorphic imaging on the SHARP extreme ultraviolet mask microscope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benk, Markus P.; Wojdyla, Antoine; Chao, Weilun

The SHARP high-numerical aperture actinic reticle review project is a synchrotron-based, extreme ultraviolet (EUV) microscope dedicated to photomask research. SHARP emulates the illumination and imaging conditions of current EUV lithography scanners and those several generations into the future. An anamorphic imaging optic with increased mask-side numerical aperture (NA) in the horizontal and increased demagnification in the vertical direction has been proposed in this paper to overcome limitations of current multilayer coatings and extend EUV lithography beyond 0.33 NA. Zoneplate lenses with an anamorphic 4×/8× NA of 0.55 are fabricated and installed in the SHARP microscope to emulate anamorphic imaging. SHARP’smore » Fourier synthesis illuminator with a range of angles exceeding the collected solid angle of the newly designed elliptical zoneplates can produce arbitrary angular source spectra matched to anamorphic imaging. A target with anamorphic dense features down to 50-nm critical dimension is fabricated using 40 nm of nickel as the absorber. In a demonstration experiment, anamorphic imaging at 0.55 4×/8× NA and 6 deg central ray angle (CRA) is compared with conventional imaging at 0.5 4× NA and 8 deg CRA. A significant contrast loss in horizontal features is observed in the conventional images. Finally, the anamorphic images show the same image quality in the horizontal and vertical directions.« less

Post-Secondary Plans, Aspirations and Profile Characteristics of Grade Ten and Eleven Students in Manitoba, 1976-1977.

ERIC Educational Resources Information Center

Russell, C. Neil; And Others

This study was undertaken because of a sharp dip in the increase rate in post-secondary enrollments in Manitoba for Fall, 1970. Research was carried out to examine the process by which Manitoba's twelfth grade students make decisions concerning post-secondary enrollment. The research provides information on students' career plans, post-secondary…

Migrant cap 'may damage' UK physics

NASA Astrophysics Data System (ADS)

Harris, Margaret

2011-01-01

Scientists have expressed concern that changes to UK immigration rules - including a sharp drop in the number of visas available for the most highly skilled migrants - could make it more difficult for universities and other institutions to recruit talented researchers from overseas.

Photoluminescence characteristics of ZnTe bulk crystal and ZnTe epilayer grown on GaAs substrate by MOVPE

NASA Astrophysics Data System (ADS)

Lü, Hai-Yan; Mu, Qi; Zhang, Lei; Lü, Yuan-Jie; Ji, Zi-Wu; Feng, Zhi-Hong; Xu, Xian-Gang; Guo, Qi-Xin

2015-12-01

Excitation power and temperature-dependent photoluminescence (PL) spectra of the ZnTe epilayer grown on (100) GaAs substrate and ZnTe bulk crystal are investigated. The measurement results show that both the structures are of good structural quality due to their sharp bound excitonic emissions and absence of the deep level structural defect-related emissions. Furthermore, in contrast to the ZnTe bulk crystal, although excitonic emissions for the ZnTe epilayer are somewhat weak, perhaps due to As atoms diffusing from the GaAs substrate into the ZnTe epilayer and/or because of the strain-induced degradation of the crystalline quality of the ZnTe epilayer, neither the donor-acceptor pair (DAP) nor conduction band-acceptor (e-A) emissions are observed in the ZnTe epilayer. This indicates that by further optimizing the growth process it is possible to obtain a high-crystalline quality ZnTe heteroepitaxial layer that is comparable to the ZnTe bulk crystal. Project supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20120131110006), the Key Science and Technology Program of Shandong Province, China (Grant No. 2013GGX10221), the Key Laboratory of Functional Crystal Materials and Device (Shandong University, Ministry of Education), China (Grant No. JG1401), the National Natural Science Foundation of China (Grant No. 61306113), the Major Research Plan of the National Natural Science Foundation of China (Grant No. 91433112), and the Partnership Project for Fundamental Technology Researches of the Ministry of Education, Culture, Sports, Science and Technology, Japan.

High-resolution dynamic imaging and quantitative analysis of lung cancer xenografts in nude mice using clinical PET/CT

PubMed Central

Wang, Ying Yi; Wang, Kai; Xu, Zuo Yu; Song, Yan; Wang, Chu Nan; Zhang, Chong Qing; Sun, Xi Lin; Shen, Bao Zhong

2017-01-01

Considering the general application of dedicated small-animal positron emission tomography/computed tomography is limited, an acceptable alternative in many situations might be clinical PET/CT. To estimate the feasibility of using clinical PET/CT with [F-18]-fluoro-2-deoxy-D-glucose for high-resolution dynamic imaging and quantitative analysis of cancer xenografts in nude mice. Dynamic clinical PET/CT scans were performed on xenografts for 60 min after injection with [F-18]-fluoro-2-deoxy-D-glucose. Scans were reconstructed with or without SharpIR method in two phases. And mice were sacrificed to extracting major organs and tumors, using ex vivo γ-counting as a reference. Strikingly, we observed that the image quality and the correlation between the all quantitive data from clinical PET/CT and the ex vivo counting was better with the SharpIR reconstructions than without. Our data demonstrate that clinical PET/CT scanner with SharpIR reconstruction is a valuable tool for imaging small animals in preclinical cancer research, offering dynamic imaging parameters, good image quality and accurate data quatification. PMID:28881772

High-resolution dynamic imaging and quantitative analysis of lung cancer xenografts in nude mice using clinical PET/CT.

PubMed

Wang, Ying Yi; Wang, Kai; Xu, Zuo Yu; Song, Yan; Wang, Chu Nan; Zhang, Chong Qing; Sun, Xi Lin; Shen, Bao Zhong

2017-08-08

Considering the general application of dedicated small-animal positron emission tomography/computed tomography is limited, an acceptable alternative in many situations might be clinical PET/CT. To estimate the feasibility of using clinical PET/CT with [F-18]-fluoro-2-deoxy-D-glucose for high-resolution dynamic imaging and quantitative analysis of cancer xenografts in nude mice. Dynamic clinical PET/CT scans were performed on xenografts for 60 min after injection with [F-18]-fluoro-2-deoxy-D-glucose. Scans were reconstructed with or without SharpIR method in two phases. And mice were sacrificed to extracting major organs and tumors, using ex vivo γ-counting as a reference. Strikingly, we observed that the image quality and the correlation between the all quantitive data from clinical PET/CT and the ex vivo counting was better with the SharpIR reconstructions than without. Our data demonstrate that clinical PET/CT scanner with SharpIR reconstruction is a valuable tool for imaging small animals in preclinical cancer research, offering dynamic imaging parameters, good image quality and accurate data quatification.

Fatal Injuries of Law Enforcement/Correctional Officers Attacked with Sharp-Edged Weapons.

PubMed

Chenpanas, Patsy; Bir, Cynthia

2017-05-01

According to the National Law Enforcement Memorial Fund, there were 117 law enforcement fatalities in the United States in 2015. Assaults with sharp-edged weapons have resulted in a total of over 400 fatalities in the United States. The goal of the current research was to examine sharp-edged weapon assaults against law enforcement and correctional agents that resulted in a fatal outcome. A total of twelve autopsy reports were reviewed from across the United States. Four cases involved law enforcement officers, seven involved correctional officers, and one was an off-duty border officer. The male-to-female ratio was 11:1. A total of 70.2% of the wounds analyzed were stab wounds (n = 85), and 29.8% of the wounds were slash wounds (n = 36). Based on this review, the neck, shoulder, and chest regions were the most vulnerable to single fatal stab/slash wounds. Multiple stab/slash wounds often resulted in exsanguination. The use of body armor was only noted in one case. © 2016 American Academy of Forensic Sciences.

Evaluation of biologic occupational risk control practices: quality indicators development and validation.

PubMed

Takahashi, Renata Ferreira; Gryschek, Anna Luíza F P L; Izumi Nichiata, Lúcia Yasuko; Lacerda, Rúbia Aparecida; Ciosak, Suely Itsuko; Gir, Elucir; Padoveze, Maria Clara

2010-05-01

There is growing demand for the adoption of qualification systems for health care practices. This study is aimed at describing the development and validation of indicators for evaluation of biologic occupational risk control programs. The study involved 3 stages: (1) setting up a research team, (2) development of indicators, and (3) validation of the indicators by a team of specialists recruited to validate each attribute of the developed indicators. The content validation method was used for the validation, and a psychometric scale was developed for the specialists' assessment. A consensus technique was used, and every attribute that obtained a Content Validity Index of at least 0.75 was approved. Eight indicators were developed for the evaluation of the biologic occupational risk prevention program, with emphasis on accidents caused by sharp instruments and occupational tuberculosis prevention. The indicators included evaluation of the structure, process, and results at the prevention and biologic risk control levels. The majority of indicators achieved a favorable consensus regarding all validated attributes. The developed indicators were considered validated, and the method used for construction and validation proved to be effective. Copyright (c) 2010 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

Assessing the viability of `over-the-loop' real-time short-to-medium range ensemble streamflow forecasts

NASA Astrophysics Data System (ADS)

Wood, A. W.; Clark, E.; Mendoza, P. A.; Nijssen, B.; Newman, A. J.; Clark, M. P.; Arnold, J.; Nowak, K. C.

2016-12-01

Many if not most national operational short-to-medium range streamflow prediction systems rely on a forecaster-in-the-loop approach in which some parts of the forecast workflow are automated, but others require the hands-on-effort of an experienced human forecaster. This approach evolved out of the need to correct for deficiencies in the models and datasets that were available for forecasting, and often leads to skillful predictions despite the use of relatively simple, conceptual models. On the other hand, the process is not reproducible, which limits opportunities to assess and incorporate process variations, and the effort required to make forecasts in this way is an obstacle to expanding forecast services - e.g., though adding new forecast locations or more frequent forecast updates, running more complex models, or producing forecast ensembles and hindcasts that can support verification. In the last decade, the hydrologic forecasting community has begun to develop more centralized, `over-the-loop' systems. The quality of these new forecast products will depend on their ability to leverage research in areas including earth system modeling, parameter estimation, data assimilation, statistical post-processing, weather and climate prediction, verification, and uncertainty estimation through the use of ensembles. Currently, the operational streamflow forecasting and water management communities have little experience with the strengths and weaknesses of over-the-loop approaches, even as the systems are being rolled out in major operational forecasting centers. There is thus a need both to evaluate these forecasting advances and to demonstrate their potential in a public arena, raising awareness in forecast user communities and development programs alike. To address this need, the National Center for Atmospheric Research is collaborating with the University of Washington, the Bureau of Reclamation and the US Army Corps of Engineers, using the NCAR 'System for Hydromet Analysis, Research, and Prediction' (SHARP) to implement, assess and demonstrate real-time over-the-loop forecasts. We present early hindcast and verification results from SHARP for short to medium range streamflow forecasts in a number of US case study watersheds.

Moving graphene devices from lab to market: advanced graphene-coated nanoprobes

NASA Astrophysics Data System (ADS)

Hui, Fei; Vajha, Pujashree; Shi, Yuanyuan; Ji, Yanfeng; Duan, Huiling; Padovani, Andrea; Larcher, Luca; Li, Xiao Rong; Xu, Jing Juan; Lanza, Mario

2016-04-01

After more than a decade working with graphene there is still a preoccupying lack of commercial devices based on this wonder material. Here we report the use of high-quality solution-processed graphene sheets to fabricate ultra-sharp probes with superior performance. Nanoprobes are versatile tools used in many fields of science, but they can wear fast after some experiments, reducing the quality and increasing the cost of the research. As the market of nanoprobes is huge, providing a solution for this problem should be a priority for the nanotechnology industry. Our graphene-coated nanoprobes not only show enhanced lifetime, but also additional unique properties of graphene, such as hydrophobicity. Moreover, we have functionalized the surface of graphene to provide piezoelectric capability, and have fabricated a nano relay. The simplicity and low cost of this method, which can be used to coat any kind of sharp tip, make it suitable for the industry, allowing production on demand.After more than a decade working with graphene there is still a preoccupying lack of commercial devices based on this wonder material. Here we report the use of high-quality solution-processed graphene sheets to fabricate ultra-sharp probes with superior performance. Nanoprobes are versatile tools used in many fields of science, but they can wear fast after some experiments, reducing the quality and increasing the cost of the research. As the market of nanoprobes is huge, providing a solution for this problem should be a priority for the nanotechnology industry. Our graphene-coated nanoprobes not only show enhanced lifetime, but also additional unique properties of graphene, such as hydrophobicity. Moreover, we have functionalized the surface of graphene to provide piezoelectric capability, and have fabricated a nano relay. The simplicity and low cost of this method, which can be used to coat any kind of sharp tip, make it suitable for the industry, allowing production on demand. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr06235g

Spacecraft Health Automated Reasoning Prototype (SHARP): The fiscal year 1989 SHARP portability evaluations task for NASA Solar System Exploration Division's Voyager project

NASA Technical Reports Server (NTRS)

Atkinson, David J.; Doyle, Richard J.; James, Mark L.; Kaufman, Tim; Martin, R. Gaius

1990-01-01

A Spacecraft Health Automated Reasoning Prototype (SHARP) portability study is presented. Some specific progress is described on the portability studies, plans for technology transfer, and potential applications of SHARP and related artificial intelligence technology to telescience operations. The application of SHARP to Voyager telecommunications was a proof-of-capability demonstration of artificial intelligence as applied to the problem of real time monitoring functions in planetary mission operations. An overview of the design and functional description of the SHARP system is also presented as it was applied to Voyager.

Development of Solution Algorithm and Sensitivity Analysis for Random Fuzzy Portfolio Selection Model

NASA Astrophysics Data System (ADS)

Hasuike, Takashi; Katagiri, Hideki

2010-10-01

This paper focuses on the proposition of a portfolio selection problem considering an investor's subjectivity and the sensitivity analysis for the change of subjectivity. Since this proposed problem is formulated as a random fuzzy programming problem due to both randomness and subjectivity presented by fuzzy numbers, it is not well-defined. Therefore, introducing Sharpe ratio which is one of important performance measures of portfolio models, the main problem is transformed into the standard fuzzy programming problem. Furthermore, using the sensitivity analysis for fuzziness, the analytical optimal portfolio with the sensitivity factor is obtained.

Strengthening community-based programming for juvenile sexual offenders: key concepts and paradigm shifts.

PubMed

Hunter, John A; Gilbertson, Stephen A; Vedros, Dani; Morton, Michael

2004-05-01

The past decade has been witness to a sharp increase in residential placement of adjudicated delinquent youth, including juvenile sexual offenders. It is argued that this trend has fiscal implications and may be clinically contraindicated for less characterologically disturbed and dangerous youth. The authors advocate greater investment of public funds in the development and refinement of community-based intervention programs. It is believed that clinically and legally integrated programming, using newer social-ecological methodologies and supports, offers promise of reducing the number of youth who require residential placement, shortening residential lengths of stay and improving the transition of residentially treated youth back into community settings. Key concepts relevant to bolstering community-based programming for juvenile sexual offenders are identified and discussed. Two programs are described, and program evaluation data reviewed, in support of the viability of innovative community-based approaches to the management of this population.

Effect of an Expenditure Cap on Low-Income Seniors' Drug Use and Spending in a State Pharmacy Assistance Program

PubMed Central

Bishop, Christine E; Ryan, Andrew M; Gilden, Daniel M; Kubisiak, Joanna; Thomas, Cindy Parks

2009-01-01

Objective To estimate the impact of a soft cap (a ceiling on utilization beyond which insured enrollees pay a higher copayment) on low-income elders' use of prescription drugs. Data Sources and Setting Claims and enrollment files for the first year (June 2002 through May 2003) of the Illinois SeniorCare program, a state pharmacy assistance program, and Medicare claims and enrollment files, 2001 through 2003. SeniorCare enrolled non-Medicaid-eligible elders with income less than 200 percent of Federal Poverty Level. Minimal copays increased by 20 percent of prescription cost when enrollee expenditures reached $1,750. Research Design Models were estimated for three dependent variables: enrollees' average monthly utilization (number of prescriptions), spending, and the proportion of drugs that were generic rather than brand. Observations included all program enrollees who exceeded the cap and covered two periods, before and after the cap was exceeded. Principle Findings On average, enrollees exceeding the cap reduced the number of drugs they purchased by 14 percent, monthly expenditures decreased by 19 percent, and the proportion generic increased by 4 percent, all significant at p<.01. Impacts were greater for enrollees with greater initial spending, for enrollees without one of five chronic illness diagnoses in the previous calendar year, and for enrollees with lower income. Conclusions Near-poor elders enrolled in plans with caps or coverage gaps, including Part D plans, may face sharp declines in utilization when they exceed these thresholds. PMID:19291168

The SMART Platform: early experience enabling substitutable applications for electronic health records.

PubMed

Mandl, Kenneth D; Mandel, Joshua C; Murphy, Shawn N; Bernstam, Elmer Victor; Ramoni, Rachel L; Kreda, David A; McCoy, J Michael; Adida, Ben; Kohane, Isaac S

2012-01-01

The Substitutable Medical Applications, Reusable Technologies (SMART) Platforms project seeks to develop a health information technology platform with substitutable applications (apps) constructed around core services. The authors believe this is a promising approach to driving down healthcare costs, supporting standards evolution, accommodating differences in care workflow, fostering competition in the market, and accelerating innovation. The Office of the National Coordinator for Health Information Technology, through the Strategic Health IT Advanced Research Projects (SHARP) Program, funds the project. The SMART team has focused on enabling the property of substitutability through an app programming interface leveraging web standards, presenting predictable data payloads, and abstracting away many details of enterprise health information technology systems. Containers--health information technology systems, such as electronic health records (EHR), personally controlled health records, and health information exchanges that use the SMART app programming interface or a portion of it--marshal data sources and present data simply, reliably, and consistently to apps. The SMART team has completed the first phase of the project (a) defining an app programming interface, (b) developing containers, and (c) producing a set of charter apps that showcase the system capabilities. A focal point of this phase was the SMART Apps Challenge, publicized by the White House, using http://www.challenge.gov website, and generating 15 app submissions with diverse functionality. Key strategic decisions must be made about the most effective market for further disseminating SMART: existing market-leading EHR vendors, new entrants into the EHR market, or other stakeholders such as health information exchanges.

A Safe Place to Stay Sharp: Action Learning Meets Cooperative Inquiry in the Service of NHS OD Capacity Building

ERIC Educational Resources Information Center

Traeger, James; Norgate, Carolyn

2015-01-01

This is an account of practice. It explores the meeting point between action learning and action research, as a way of doing capacity building in organisational development (OD) in the NHS in the UK. The authors were part of a short cooperative inquiry (Heron, J. 1996. "Co-operative Inquiry: Research into the Human Condition." London:…

Demonstrating Understanding, a Whole Body Experience? Can Year One Children Show Their Science Understanding through the Use of Gestures?

ERIC Educational Resources Information Center

Davis, Anthony

2016-01-01

This research project uses the methods of Crowder and Callinan and Sharp to assess year one children's (age 5-6) personal understanding of scientific concepts. This research project uses video recording as a primary resource of data collection within a case study approach using a participant observer method. Analysis supports the work of Crowder…

Explorations in Education and Public Outreach in Space Sciences - a Wisconsin Experience

NASA Astrophysics Data System (ADS)

Limaye, S. S.; Pertzborn, R. A.

1999-09-01

To better serve the Education and Public Outreach needs of federally funded space science research programs at the University of Wisconsin, an Office of Space Science Education has recently been established on the University of Wisconsin-Madison campus. This office also acts as the campus focus for the Wisconsin Space Grant Consortium, and has undertaken a broad spectrum of interdisciplinary space science programs in the past several years. These activities range from a public exhibition focusing on current space exploration in conjunction with the DPS '98 meeting in Madison, WI that attracted over 5,000 students and teachers from across the state, to organizing state-of-the-art HDTV presentations on earth remote sensing topics at a Milwaukee science museum. Programs for students have included development and support of a six week solar system exploration program in the Milwaukee Public Schools for at-risk students, a two week college access program for minority middle school students, the NASA/QEM/SHARP Plus program for minority high school students, and a web based journal for middle school science projects (SPARK). Teacher professional development efforts include summer workshops for academic credit, year-round classroom support for pilot school programs, and support for development of standards-based curriculum in both space science and earth remote sensing topics. Public outreach activities have included evening family activities and public lectures at the Space Place, an off-campus outreach center, and an ask-a-scientist web based program. These efforts continue to affirm the need for effective outreach programs for diverse and multigenerational communities. In spite of the growing recognition at both the state and federal level for an improved level of literacy in the space-related sciences, sustainable support, program opportunities and logistical implementation continue to pose significant challenges. We gratefully acknowledge the support we have received from NASA, NOAA, the Division for Planetary Sciences of the AAS (space exploration exhibition), the University of Wisconsin System and the Eisenhower Professional Development Program.

Culturally Responsive Pedagogies in Arizona and Latino Students' Achievement

ERIC Educational Resources Information Center

López, Francesca A.

2016-01-01

Background: Despite numerous educational reform efforts aimed at aggressively addressing achievement disparities, Latinos continue to underperform in school. In sharp contrast to the belief that the inordinate achievement disparities among Latino students stem from deficiencies, some researchers assert that culturally responsive teaching (CRT)…

Mice Lacking the Circadian Modulators SHARP1 and SHARP2 Display Altered Sleep and Mixed State Endophenotypes of Psychiatric Disorders

PubMed Central

Shahmoradi, Ali; Reinecke, Lisa; Kroos, Christina; Wichert, Sven P.; Oster, Henrik; Wehr, Michael C.; Taneja, Reshma; Hirrlinger, Johannes; Rossner, Moritz J.

2014-01-01

Increasing evidence suggests that clock genes may be implicated in a spectrum of psychiatric diseases, including sleep and mood related disorders as well as schizophrenia. The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC2/BHLHE40 has been shown to regulate homeostatic sleep drive in humans. In this study, we characterized Sharp1 and Sharp2 double mutant mice (S1/2-/-) using online EEG recordings in living animals, behavioral assays and global gene expression profiling. EEG recordings revealed attenuated sleep/wake amplitudes and alterations of theta oscillations. Increased sleep in the dark phase is paralleled by reduced voluntary activity and cortical gene expression signatures reveal associations with psychiatric diseases. S1/2-/- mice display alterations in novelty induced activity, anxiety and curiosity. Moreover, mutant mice exhibit impaired working memory and deficits in prepulse inhibition resembling symptoms of psychiatric diseases. Network modeling indicates a connection between neural plasticity and clock genes, particularly for SHARP1 and PER1. Our findings support the hypothesis that abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 and SHARP2. PMID:25340473

[Perceptual sharpness metric for visible and infrared color fusion images].

PubMed

Gao, Shao-Shu; Jin, Wei-Qi; Wang, Xia; Wang, Ling-Xue; Luo, Yuan

2012-12-01

For visible and infrared color fusion images, objective sharpness assessment model is proposed to measure the clarity of detail and edge definition of the fusion image. Firstly, the contrast sensitivity functions (CSF) of the human visual system is used to reduce insensitive frequency components under certain viewing conditions. Secondly, perceptual contrast model, which takes human luminance masking effect into account, is proposed based on local band-limited contrast model. Finally, the perceptual contrast is calculated in the region of interest (contains image details and edges) in the fusion image to evaluate image perceptual sharpness. Experimental results show that the proposed perceptual sharpness metrics provides better predictions, which are more closely matched to human perceptual evaluations, than five existing sharpness (blur) metrics for color images. The proposed perceptual sharpness metrics can evaluate the perceptual sharpness for color fusion images effectively.

Quantifying and Modelling the Effect of Cloud Shadows on the Surface Irradiance at Tropical and Midlatitude Forests

NASA Astrophysics Data System (ADS)

Kivalov, Sergey N.; Fitzjarrald, David R.

2018-02-01

Cloud shadows lead to alternating light and dark periods at the surface, with the most abrupt changes occurring in the presence of low-level forced cumulus clouds. We examine multiyear irradiance time series observed at a research tower in a midlatitude mixed deciduous forest (Harvard Forest, Massachusetts, USA: 42.53{°}N, 72.17{°}W) and one made at a similar tower in a tropical rain forest (Tapajós National Forest, Pará, Brazil: 2.86{°}S, 54.96{°}W). We link the durations of these periods statistically to conventional meteorological reports of sky type and cloud height at the two forests and present a method to synthesize the surface irradiance time series from sky-type information. Four classes of events describing distinct sequential irradiance changes at the transition from cloud shadow and direct sunlight are identified: sharp-to-sharp, slow-to-slow, sharp-to-slow, and slow-to-sharp. Lognormal and the Weibull statistical distributions distinguish among cloudy-sky types. Observers' qualitative reports of `scattered' and `broken' clouds are quantitatively distinguished by a threshold value of the ratio of mean clear to cloudy period durations. Generated synthetic time series based on these statistics adequately simulate the temporal "radiative forcing" linked to sky type. Our results offer a quantitative way to connect the conventional meteorological sky type to the time series of irradiance experienced at the surface.

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, HVLP COATING EQUIPMENT, SHARPE MANUFACTURING COMPANY PLATINUM 2012 HVLP SPRAY GUN

EPA Science Inventory

This report presents the results of the verification test of the Sharpe Platinum 2013 high-volume, low-pressure gravity-feed spray gun, hereafter referred to as the Sharpe Platinum, which is designed for use in automotive refinishing. The test coating chosen by Sharpe Manufacturi...

High Strain Rate Material Behavior

DTIC Science & Technology

1985-12-01

data. iii Mr. Dennis Paisely conducted the single plate impact test. Mr. Danny Yaziv is responsible for developing the double flyer plate technique and...neck developed . The sharp rise in the flow stress is due to the increased strain-rates during necking. The maximum observed value of effective stress...for the material modeling. Computer programs and special purpose subroutines were developed to use the Bodner-Partom model in the STEALTH finite

Swirl-Stabilized Injector Flow and Combustion Dynamics for Liquid Propellants at Supercritical Conditions

DTIC Science & Technology

2007-02-08

was employed to study the vapor cavitation during liquid carbon dioxide expansion through a sharp-orifice nozzle. Numerical experiments demonstrated...Combustion Dynamics for 6b. GRANT NUMBER Liquid Propellants at Supercritical Conditions FA9550-04-1-0014 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...fundamental knowledge of supercritical combustion of liquid propellants under conditions representative of contemporary rocket engines. Both shear and

The large-scale structure of the asteroid belt

NASA Technical Reports Server (NTRS)

Zellner, B.; Thirunagari, A.; Bender, D.

1985-01-01

The distributions of 2888 numbered minor planets over orbital inclination, eccentricity, and semimajor axis are examined, and 19 zones believed to adequately isolate the selection biases in survey programs of the physical properties of minor planets are defined. Six numbered asteroids have exceptional orbits and fall into no zone. Attention is called to rather sharp upper limits, which become increasingly stringent at larger heliocentric distances, on orbital inclinations and eccentricity.

Using Computers in the Programming of Qualifying Teachers of Arabic in the Faculties of Education in Egypt.

ERIC Educational Resources Information Center

Mahmoud, Abdelrahman Kamel Abdelrahman

In Egypt, teachers of Arabic do not study the computer in the syllabus of their preparation in Faculties of Education. Moreover, they do not use it in studying any of the syllabi until they graduate as teachers. This issue seems to have been lost between the extreme simplification of technicians from one side, and the sharp overlook of linguistics…

77 FR 52061 - Notice of Proposed Exemption Involving Sharp HealthCare Located in San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-28

...This document contains a notice of pendency (the Notice) before the Department of Labor (the Department) of a proposed individual exemption from certain prohibited transaction restrictions of the Employee Retirement Income Security Act of 1974 (the Act or ERISA). The transactions involve the Sharp HealthCare Health and Dental Plan (the Plan). The proposed exemption, if granted, would affect the Plan, its participants and beneficiaries, Sharp Healthcare (Sharp), and the Sharp Health Plan (the HMO).

Insulin stimulates the expression of the SHARP-1 gene via multiple signaling pathways.

PubMed

Takagi, K; Asano, K; Haneishi, A; Ono, M; Komatsu, Y; Yamamoto, T; Tanaka, T; Ueno, H; Ogawa, W; Tomita, K; Noguchi, T; Yamada, K

2014-06-01

The rat enhancer of split- and hairy-related protein-1 (SHARP-1) is a basic helix-loop-helix transcription factor. An issue of whether SHARP-1 is an insulin-inducible transcription factor was examined. Insulin rapidly increased the level of SHARP-1 mRNA both in vivo and in vitro. Then, signaling pathways involved with the increase of SHARP-1 mRNA by insulin were determined in H4IIE rat hepatoma cells. Pretreatments with LY294002, wortmannin, and staurosporine completely blocked the induction effect, suggesting the involvement of both phosphoinositide 3-kinase (PI 3-K) and protein kinase C (PKC) pathways. In fact, overexpression of a dominant negative form of atypical protein kinase C lambda (aPKCλ) significantly decreased the induction of the SHARP-1 mRNA. In addition, inhibitors for the small GTPase Rac or Jun N-terminal kinase (JNK) also blocked the induction of SHARP-1 mRNA by insulin. Overexpression of a dominant negative form of Rac1 prevented the activation by insulin. Furthermore, actinomycin D and cycloheximide completely blocked the induction of SHARP-1 mRNA by insulin. Finally, when a SHARP-1 expression plasmid was transiently transfected with various reporter plasmids into H4IIE cells, the promoter activity of PEPCK reporter plasmid was specifically decreased. Thus, we conclude that insulin induces the SHARP-1 gene expression at the transcription level via a both PI 3-K/aPKCλ/JNK- and a PI 3-K/Rac/JNK-signaling pathway; protein synthesis is required for this induction; and that SHARP-1 is a potential repressor of the PEPCK gene expression. © Georg Thieme Verlag KG Stuttgart · New York.

Background field removal technique using regularization enabled sophisticated harmonic artifact reduction for phase data with varying kernel sizes.

PubMed

Kan, Hirohito; Kasai, Harumasa; Arai, Nobuyuki; Kunitomo, Hiroshi; Hirose, Yasujiro; Shibamoto, Yuta

2016-09-01

An effective background field removal technique is desired for more accurate quantitative susceptibility mapping (QSM) prior to dipole inversion. The aim of this study was to evaluate the accuracy of regularization enabled sophisticated harmonic artifact reduction for phase data with varying spherical kernel sizes (REV-SHARP) method using a three-dimensional head phantom and human brain data. The proposed REV-SHARP method used the spherical mean value operation and Tikhonov regularization in the deconvolution process, with varying 2-14mm kernel sizes. The kernel sizes were gradually reduced, similar to the SHARP with varying spherical kernel (VSHARP) method. We determined the relative errors and relationships between the true local field and estimated local field in REV-SHARP, VSHARP, projection onto dipole fields (PDF), and regularization enabled SHARP (RESHARP). Human experiment was also conducted using REV-SHARP, VSHARP, PDF, and RESHARP. The relative errors in the numerical phantom study were 0.386, 0.448, 0.838, and 0.452 for REV-SHARP, VSHARP, PDF, and RESHARP. REV-SHARP result exhibited the highest correlation between the true local field and estimated local field. The linear regression slopes were 1.005, 1.124, 0.988, and 0.536 for REV-SHARP, VSHARP, PDF, and RESHARP in regions of interest on the three-dimensional head phantom. In human experiments, no obvious errors due to artifacts were present in REV-SHARP. The proposed REV-SHARP is a new method combined with variable spherical kernel size and Tikhonov regularization. This technique might make it possible to be more accurate backgroud field removal and help to achive better accuracy of QSM. Copyright © 2016 Elsevier Inc. All rights reserved.

Simulating shock-bubble interactions at water-gelatin interfaces

NASA Astrophysics Data System (ADS)

Adami, Stefan; Kaiser, Jakob; Bermejo-Moreno, Ivan; Adams, Nikolaus

2016-11-01

Biomedical problems are often driven by fluid dynamics, as in vivo organisms are usually composed of or filled with fluids that (strongly) affected their physics. Additionally, fluid dynamical effects can be used to enhance certain phenomena or destroy organisms. As examples, we highlight the benign potential of shockwave-driven kidney-stone lithotripsy or sonoporation (acoustic cavitation of microbubbles) to improve drug delivery into cells. During the CTR SummerProgram 2016 we have performed axisymmetric three-phase simulations of a shock hitting a gas bubble in water near a gelatin interface mimicking the fundamental process during sonoporation. We used our multi-resolution finite volume method with sharp interface representation (level-set), WENO-5 shock capturing and interface scale-separation and compared the results with a diffuse-interface method. Qualitatively our simulation results agree well with the reference. Due to the interface treatment the pressure profiles are sharper in our simulations and bubble collapse dynamics are predicted at shorter time-scales. Validation with free-field collapse (Rayleigh collapse) shows very good agreement. The project leading to this application has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No 667483).

Connections between density, wall-normal velocity, and coherent structure in a heated turbulent boundary layer

NASA Astrophysics Data System (ADS)

Saxton-Fox, Theresa; Gordeyev, Stanislav; Smith, Adam; McKeon, Beverley

2015-11-01

Strong density gradients associated with turbulent structure were measured in a mildly heated turbulent boundary layer using an optical sensor (Malley probe). The Malley probe measured index of refraction gradients integrated along the wall-normal direction, which, due to the proportionality of index of refraction and density in air, was equivalently an integral measure of density gradients. The integral output was observed to be dominated by strong, localized density gradients. Conditional averaging and Pearson correlations identified connections between the streamwise gradient of density and the streamwise gradient of wall-normal velocity. The trends were suggestive of a process of pick-up and transport of heat away from the wall. Additionally, by considering the density field as a passive marker of structure, the role of the wall-normal velocity in shaping turbulent structure in a sheared flow was examined. Connections were developed between sharp gradients in the density and flow fields and strong vertical velocity fluctuations. This research is made possible by the Department of Defense through the National Defense & Engineering Graduate Fellowship (NDSEG) Program and by the Air Force Office of Scientific Research Grant # FA9550-12-1-0060.

Pilot Biofeedback Training in the Cognitive Awareness Training Study (CATS)

NASA Technical Reports Server (NTRS)

Uenking, M.

2000-01-01

One of the ongoing problems that pilots face today is a diminished state of awareness such as boredom, sleepiness, or fatigue during cruise conditions that could result in various pilot errors. This study utilized a cognitive training exercise to sharpen the pilot's awareness during simulated flight thereby providing them with a means to overcome these diminished states of awareness. This study utilizes psychophysiological methods in an attempt to assess a pilot's state of awareness more directly. In turn, the pilots will be able to train themselves to recognize these states of awareness and be more mentally sharp during mundane tasks such as those experienced in cruise conditions. The use of these measurement tools may be beneficial for researchers working within the NASA Aviation Safety Program. This paper will provide the reader with some background information concerning the motivation for the study, a brief description of the experimental setup and design matrix, the dependent and independent variables that were employed, and some preliminary findings based on some of the subjective and objective data that was collected. These preliminary findings are of part of an ongoing study being conducted at the NASA Langley Research Center in Hampton, Virginia.

Swept shock/boundary layer interaction experiments in support of CFD code validation

NASA Technical Reports Server (NTRS)

Settles, G. S.; Lee, Y.

1992-01-01

Research on the topic of shock wave/turbulent boundary-layer interaction was carried out during the past three years at the Penn State Gas Dynamics Laboratory. This report describes the experimental research program which provides basic knowledge and establishes new data on heat transfer in swept shock wave/boundary-layer interactions. An equilibrium turbulent boundary-layer on a flat plate is subjected to impingement by swept planar shock waves generated by a sharp fin. Five different interactions with fin angle ranging from 10 deg to 20 deg at freestream Mach numbers of 3.0 and 4.0 produce a variety of interaction strengths from weak to very strong. A foil heater generates a uniform heat flux over the flat plate surface, and miniature thin-film-resistance sensors mounted on it are used to measure the local surface temperature. The heat convection equation is then solved for the heat transfer distribution within an interaction, yielding a total uncertainty of about +/- 10 percent. These experimental data are compared with the results of numerical Navier-Stokes solutions which employ a k-epsilon turbulence model. Finally, a simplified form of the peak heat transfer correlation for fin interactions is suggested.

SHARP: Spacecraft Health Automated Reasoning Prototype

NASA Technical Reports Server (NTRS)

Atkinson, David J.

1991-01-01

The planetary spacecraft mission OPS as applied to SHARP is studied. Knowledge systems involved in this study are detailed. SHARP development task and Voyager telecom link analysis were examined. It was concluded that artificial intelligence has a proven capability to deliver useful functions in a real time space flight operations environment. SHARP has precipitated major change in acceptance of automation at JPL. The potential payoff from automation using AI is substantial. SHARP, and other AI technology is being transferred into systems in development including mission operations automation, science data systems, and infrastructure applications.

The Evolution of Organization Analysis in ASQ, 1959-1979.

ERIC Educational Resources Information Center

Daft, Richard L.

1980-01-01

During the period 1959-1979, a sharp trend toward low-variety statistical languages has taken place, which may represent an organizational mapping phase in which simple, quantifiable relationships have been formally defined and measured. A broader scope of research languages will be needed in the future. (Author/IRT)

Metaphor Foundations in Creativity Research: Boundary vs. Organism

ERIC Educational Resources Information Center

Moran, Seana

2009-01-01

Two metaphors explicitly or implicitly used in the conceptualization of creativity are examined and compared. The boundary metaphor describes creativity in terms of crossing or pushing out a frontier. This metaphor underlies studies that emphasize creativity as a moment--an "aha!" experience or a sharp break from tradition. The organism metaphor…

Lecture 3: Some Suggestions and Remarks upon Observing Children

ERIC Educational Resources Information Center

Montessori, Maria

2016-01-01

These next two lectures succinctly discuss the necessary preparation and methods for observation. Using the naturalist Fabre as an example of scientific training of the faculties for sharp observation, Montessori compares the observer to a researcher and gives many suggestions for conducting thorough yet unobtrusive observation. Self-awareness of…

Mentoring: A Model for Leadership Development?

ERIC Educational Resources Information Center

Stead, Valerie

2005-01-01

There appears to be a paucity of research on mentoring senior leaders (Hobson & Sharp, 2005) and yet a growing interest in the development of leadership through experience (Abra "et al.," 2003; McCauley "et al.," 1998). This paper therefore presents and evaluates a case study of a pilot mentoring scheme and programme for…

Integrating Place and Time with Tasks: Supporting the Student Commuter

ERIC Educational Resources Information Center

Lackey, Stephen

2014-01-01

Though the role of traveler information in transportation has been widely recognized in Activity Analysis research, the needs of specific populations receive limited attention. The commuting burden on community college students received comparatively little attention, despite first semester attrition rates and sharp declines in observed parking…

EXPERIMENTAL EVALUATION OF TWO SHARP FRONT MODELS FOR VADOSE ZONE NON-AQUEOUS PHASE LIQUID TRANSPORT

EPA Science Inventory

Recent research efforts on the transport of immiscible organic wastes in subsurface the development of numerical models of various levels of sophistication. Systems have focused on the site characterization data needed to obtain. However, in real field applications, the model p...

The Ethno-Cultural Concept of Classical Eurasianism

ERIC Educational Resources Information Center

Ivanov, Andrey V.; Fotieva, Irina V.; Shishin, Michail Yu.; Belokurovac, Sofja M.

2016-01-01

The purpose of this study is to analyze of Eurasianism, which began during the Russian scientific and philosophical emigration and has generated sharp discussion over the last century. Within the framework of Eurasianism, extensive research has been conducted on a wide range of interrelated topics, much of whose theoretical and practical…

Prediction of Cavitating Waterjet Propulsor Performance Using a Boundary Element Method

DTIC Science & Technology

2007-10-01

addressed. Instead, the Young, Y.L., Numerical Modeling of Supercavitating round trailing edge is modified to be a sharp one by and Surface-Piercing... Supercavitating Propeller Flows," Journal of Ship circulation distribution, and thus on the predicted thrust Research, Vol. 47, pp. 48-62, March 2003. and

Shame, Guilt, and Depressive Symptoms: A Meta-Analytic Review

ERIC Educational Resources Information Center

Kim, Sangmoon; Thibodeau, Ryan; Jorgensen, Randall S.

2011-01-01

Recent theoretical and empirical work has facilitated the drawing of sharp conceptual distinctions between shame and guilt. A clear view of these distinctions has permitted development of a research literature aimed at evaluating the differential associations of shame and guilt with depressive symptoms. This study quantitatively summarized the…

Sex as Reported in a Recent Sample of Psychological Research

ERIC Educational Resources Information Center

Reardon, Patrice; Prescott, Suzanne

1977-01-01

Articles taken from the Journal of Personality and Social Psychology 1974 were reviewed for sex of subjects and type of conclusion drawn. Contrary to the Schwabacher study, the percentage of all male studies show a sharp drop of 15 percent while all female studies rose 22 percent. (Author)

Preoperative and Postoperative Photographs and Surgical Outcomes of Patients With Kyphosis.

PubMed

Albayrak, Akif; Balioglu, Mehmet Bulent; Misir, Abdulhamit; Kargin, Deniz; Tacal, Mehmet Temel; Atici, Yunus; Kaygusuz, Mehmet Akif

2016-10-01

A retrospective clinical study was performed. The aim of the study was to show patients their pre- and postoperative body photographs, and determine the effect on postoperative patient satisfaction for thoracic and thoracolumbar sharp and round angular kyphosis. Previous studies have reported the normative values of pelvic sagittal parameters and the classification of normal patterns of sagittal curvature, but no study has investigated and compared the clinical photographs of sharp and round kyphosis. In patients who underwent surgery for thoracic and thoracolumbar sharp and round angular kyphosis, whole spine anteroposterior and lateral radiographs, and clinical photographs were obtained preoperatively and at the final follow-up. Pelvic and spinal parameters were measured, and the pre- and postoperative photographs were shown to patients. The Scoliosis Research Society 22r (SRS22r) and Short Form 36 surveys were administered to all patients, and the scores were analyzed. Thirty-eight patients diagnosed with kyphosis (mean age 19.6 yr, mean follow-up duration 26.4 mo) were divided into two groups: sharp (18 patients, mean age 20.1 yr) and round (20 patients, mean age 19.6 yr) kyphosis. There was no difference between values in the sharp and round groups in terms of age, follow-up duration, and Risser score (P > 0.05). In both groups, the subscores for pain, self-image, mental health, and satisfaction, except for the function/activity score, and the total score of the SRS22r survey were, however, significantly different between pre- and postoperative photographs. In addition, there was no significant difference between the two groups in any SRS22r domain and Short Form 36 scores. The surgical treatment of kyphosis was uniformly associated with improved quality of life, regardless of the kyphosis type. Thus, showing patients their pre- and postoperative photographs may enhance patient satisfaction, as measured by SRS22r scores. 4.

Psychometric properties of the Children's Scale of Hostility and Aggression: Reactive/Proactive (C-SHARP).

PubMed

Farmer, Cristan A; Aman, Michael G

2010-01-01

Although often lacking "malice", aggression is fairly common in children with intellectual or developmental disability (I/DD). Despite this, there are no scales available that are appropriate for an in-depth analysis of aggressive behavior in this population. Such scales are needed for the study of aggressive behavior, which is a common target symptom in clinical trials. We assessed the reliability and validity of the Children's Scale of Hostility and Aggression: Reactive/Proactive (C-SHARP), a new aggression scale created for children with I/DD. Data are presented from a survey of 365 children with I/DD aged 3-21 years. Interrater reliability was very high for the Problem Scale, which characterizes type of aggression. Reliability was lower but largely acceptable for the Provocation Scale, which assesses motivation. Validity of the Problem Scale was supported by expected differences in children with autism, Down syndrome, comorbid disruptive behavior disorders (DBDs) and ADHD. The Provocation Scale, which categorizes behavior as proactive or reactive, showed expected differences in children with DBD, but was less effective in those with ADHD. The C-SHARP appears to have fundamentally sound psychometric characteristics, although more research is needed.

"Mr. Dewey Is Crazy and Katharine Sharp Hates the University of Chicago:" Gender, Power, and Personality and the Demise of the University of Chicago Course in Library Science 1897-1903

ERIC Educational Resources Information Center

Stauffer, Suzanne M.

2015-01-01

In 1897, the University of Chicago Extension Division began offering what we today would call "bibliographic instruction" under the aegis of the Bureau of Information of the Illinois State Library Association. The program was expanded under university librarian Zella Allen Dixson, and by 1900 was designed to train librarians and library…

An acoustofluidic micromixer based on oscillating sidewall sharp-edges.

PubMed

Huang, Po-Hsun; Xie, Yuliang; Ahmed, Daniel; Rufo, Joseph; Nama, Nitesh; Chen, Yuchao; Chan, Chung Yu; Huang, Tony Jun

2013-10-07

Rapid and homogeneous mixing inside a microfluidic channel is demonstrated via the acoustic streaming phenomenon induced by the oscillation of sidewall sharp-edges. By optimizing the design of the sharp-edges, excellent mixing performance and fast mixing speed can be achieved in a simple device, making our sharp-edge-based acoustic micromixer a promising candidate for a wide variety of applications.

Composite, ordered material having sharp surface features

DOEpatents

D'Urso, Brian R.; Simpson, John T.

2006-12-19

A composite material having sharp surface features includes a recessive phase and a protrusive phase, the recessive phase having a higher susceptibility to a preselected etchant than the protrusive phase, the composite material having an etched surface wherein the protrusive phase protrudes from the surface to form a sharp surface feature. The sharp surface features can be coated to make the surface super-hydrophobic.

Image sharpness assessment based on wavelet energy of edge area

NASA Astrophysics Data System (ADS)

Li, Jin; Zhang, Hong; Zhang, Lei; Yang, Yifan; He, Lei; Sun, Mingui

2018-04-01

Image quality assessment is needed in multiple image processing areas and blur is one of the key reasons of image deterioration. Although great full-reference image quality assessment metrics have been proposed in the past few years, no-reference method is still an area of current research. Facing this problem, this paper proposes a no-reference sharpness assessment method based on wavelet transformation which focuses on the edge area of image. Based on two simple characteristics of human vision system, weights are introduced to calculate weighted log-energy of each wavelet sub band. The final score is given by the ratio of high-frequency energy to the total energy. The algorithm is tested on multiple databases. Comparing with several state-of-the-art metrics, proposed algorithm has better performance and less runtime consumption.

Models to describe the thermal development rates of Cycloneda sanguinea L. (Coleoptera: Coccinelidae).

PubMed

Pachú, Jéssica Ks; Malaquias, José B; Godoy, Wesley Ac; de S Ramalho, Francisco; Almeida, Bruna R; Rossi, Fabrício

2018-04-01

Precise estimates of the lower (T min ) and higher (T max ) thermal thresholds as well as the temperature range that provides optimum performance (T opt ) enable to obtain the desired number of individuals in conservation systems, rearing and release of natural enemies. In this study, the relationship between the development rates of Cycloneda sanguinea L. (Coleoptera: Coccinelidae) and temperature was described using non-linear models developed by Analytis, Brière, Lactin, Lamb, Logan and Sharpe & DeMichele. There were differences between the models, considering the estimates of the parameters T min , T max , and T opt . All of the tested models were able to describe non-linear responses involving the development rates of C. sanguinea at constant temperatures. Lactin and Lamb gave the highest z weight for egg, while Analytis, Sharpe & DeMichele and Brière gave the highest values for larvae and pupae. The more realistic T opt estimated by the models varied from 29° to 31°C for egg, 27-28 °C for larvae and 28-29 °C for pupae. The Logan, Lactin and Analytis models estimated the T max for egg, larvae and pupae to be approximately 34 °C, while the T min estimated by the Analytis model was 16 °C for larvae and pupae. The information generated by our research will contribute towards improving the rearing and release of C. sanguinea in biological control programs, accurately controlling the rate of development in laboratory conditions or even scheduling the most favourable this species' release. Copyright © 2018 Elsevier Ltd. All rights reserved.

Beyond SHARP-- Primary Formaldehyde from Oil and Gas Exploration and Production in the Gulf of Mexico Region

NASA Astrophysics Data System (ADS)

Olaguer, E. P.

2010-12-01

Formaldehyde has been named by the EPA as a hazardous air pollutant that may be carcinogenic and also cause irritation to the eyes, nose, throat and lung. Moreover, it is a powerful radical and ozone precursor. The 2009 Study of Houston Atmospheric Radical Precursors (SHARP) was conceived by the Houston Advanced Research Center (HARC) on behalf of the Texas Environmental Research Consortium (TERC) to examine the relative importance of primary and secondary formaldehyde (HCHO) and nitrous acid (HONO) in ozone formation. SHARP confirmed that primary combustion sources of HCHO, such as flares end engines, may be underestimated (by an order of magnitude or more) in official emission inventories used for the purpose of air quality modeling in highly industrialized areas such as Houston. This presentation provides recently generated modeling and observational evidence that the same may be true in both rural and urban areas with oil and gas exploration and production (E&P) activities, such as the Upper Green River Basin of Wyoming and the Barnett Shale of Texas. Oil and gas E&P is increasing in the Gulf of Mexico region, particularly in the Barnett, Haynesville, Eagle Ford, Cana-Woodford, and Fayetteville shale basins. In the Barnett Shale, E&P activities are moving into urban neighborhoods, and may affect the ability to bring the Dallas-Ft. Worth region into attainment of the federal ozone standard. Data concerning formaldehyde emissions from drill rig and pipeline compressor engines, flares, and glycol or amine reboilers, should be obtained in order to more accurately model air quality in the Gulf of Mexico region.

An Evaluation of Sharp Cut Cyclones for Sampling Diesel Particulate Matter Aerosol in the Presence of Respirable Dust

PubMed Central

Cauda, Emanuele; Sheehan, Maura; Gussman, Robert; Kenny, Lee; Volkwein, Jon

2015-01-01

Two prototype cyclones were the subjects of a comparative research campaign with a diesel particulate matter sampler (DPMS) that consists of a respirable cyclone combined with a downstream impactor. The DPMS is currently used in mining environments to separate dust from the diesel particulate matter and to avoid interferences in the analysis of integrated samples and direct-reading monitoring in occupational environments. The sampling characteristics of all three devices were compared using ammonium fluorescein, diesel, and coal dust aerosols. With solid spherical test aerosols at low particle loadings, the aerodynamic size-selection characteristics of all three devices were found to be similar, with 50% penetration efficiencies (d50) close to the design value of 0.8 µm, as required by the US Mine Safety and Health Administration for monitoring occupational exposure to diesel particulate matter in US mining operations. The prototype cyclones were shown to have ‘sharp cut’ size-selection characteristics that equaled or exceeded the sharpness of the DPMS. The penetration of diesel aerosols was optimal for all three samplers, while the results of the tests with coal dust induced the exclusion of one of the prototypes from subsequent testing. The sampling characteristics of the remaining prototype sharp cut cyclone (SCC) and the DPMS were tested with different loading of coal dust. While the characteristics of the SCC remained constant, the deposited respirable coal dust particles altered the size-selection performance of the currently used sampler. This study demonstrates that the SCC performed better overall than the DPMS. PMID:25060240

Psychology of the Embrace: How Body Rhythms Communicate the Need to Indulge or Separate.

PubMed

Koch, Sabine C; Rautner, Helena

2017-11-29

In the context of embodiment research, there has been a growing interest in phenomena of interpersonal resonance. Given that haptic communication is particularly under-researched, we focused on the phenomenon of embracing. When we embrace a dear friend to say good-bye at the end of a great evening, we typically first employ smooth and yielding movements with round transitions between muscular tensing and relaxing ( smooth , indulging rhythms ), and when the embrace is getting too long, we start to use slight patting ( sharp , fighting rhythms with sharp transitions) on the back or the shoulders of the partner in order to indicate that we now want to end the embrace. On the ground of interpersonal resonance, most persons (per-sonare, latin = to sound through) understand these implicit nonverbal signals, expressed in haptic tension-flow changes, and will react accordingly. To experimentally test the hypothesis that smooth, indulgent rhythms signal the wish to continue, and sharp, fighting rhythms signal the wish to separate from an embrace, we randomly assigned 64 participants, all students at the University of Heidelberg, to two differently sequenced embrace conditions: (a) with the fighting rhythm at the end of the sequence of two indulgent rhythms (Sequence A: smooth-smooth-sharp); and (b) with the fighting rhythm between two indulgent rhythms (Sequence B: smooth-sharp-smooth). Participants were embraced for 30 s by a female confe-derate with their eyes blindfolded to focus on haptic and kinesthetic cues without being distracted by visual cues. They were instructed to let go of a handkerchief that they held between the fingers of their dominant hand during the embrace, when they felt that the embracer signaled the wish to finish the embrace. Participants significantly more often dropped the handkerchief in the phase of the fighting rhythm, no matter in which location it occurred in the embrace sequence. We assume that we learn such rhythmic behaviors and their meaning from the beginning of life in the communication with caregivers and meaningful others. Some are universal and some are quite idiosyncratic. Infants seem to be highly sensitive to the dynamic nuances presented to them, demonstrating a high capacity for embodied resonance and a high behavioral plasticity. Such adaptive mechanisms are assumed to lay the foundations of family culture (including the degree to which nonverbal cues are attended to, the communication of taboos, etc.) and larger culture, and may also play an important role in interpersonal attraction and aesthetic experience.

Psychology of the Embrace: How Body Rhythms Communicate the Need to Indulge or Separate

PubMed Central

Rautner, Helena

2017-01-01

In the context of embodiment research, there has been a growing interest in phenomena of interpersonal resonance. Given that haptic communication is particularly under-researched, we focused on the phenomenon of embracing. When we embrace a dear friend to say good-bye at the end of a great evening, we typically first employ smooth and yielding movements with round transitions between muscular tensing and relaxing (smooth, indulging rhythms), and when the embrace is getting too long, we start to use slight patting (sharp, fighting rhythms with sharp transitions) on the back or the shoulders of the partner in order to indicate that we now want to end the embrace. On the ground of interpersonal resonance, most persons (per-sonare, latin = to sound through) understand these implicit nonverbal signals, expressed in haptic tension-flow changes, and will react accordingly. To experimentally test the hypothesis that smooth, indulgent rhythms signal the wish to continue, and sharp, fighting rhythms signal the wish to separate from an embrace, we randomly assigned 64 participants, all students at the University of Heidelberg, to two differently sequenced embrace conditions: (a) with the fighting rhythm at the end of the sequence of two indulgent rhythms (Sequence A: smooth-smooth-sharp); and (b) with the fighting rhythm between two indulgent rhythms (Sequence B: smooth-sharp-smooth). Participants were embraced for 30 s by a female confe­derate with their eyes blindfolded to focus on haptic and kinesthetic cues without being distracted by visual cues. They were instructed to let go of a handkerchief that they held between the fingers of their dominant hand during the embrace, when they felt that the embracer signaled the wish to finish the embrace. Participants significantly more often dropped the handkerchief in the phase of the fighting rhythm, no matter in which location it occurred in the embrace sequence. We assume that we learn such rhythmic behaviors and their meaning from the beginning of life in the communication with caregivers and meaningful others. Some are universal and some are quite idiosyncratic. Infants seem to be highly sensitive to the dynamic nuances presented to them, demonstrating a high capacity for embodied resonance and a high behavioral plasticity. Such adaptive mechanisms are assumed to lay the foundations of family culture (including the degree to which nonverbal cues are attended to, the communication of taboos, etc.) and larger culture, and may also play an important role in interpersonal attraction and aesthetic experience. PMID:29186070

An acoustofluidic micromixer based on oscillating sidewall sharp-edges†

PubMed Central

Huang, Po-Hsun; Xie, Yuliang; Ahmed, Daniel; Rufo, Joseph; Nama, Nitesh; Chen, Yuchao; Chan, Chung Yu; Huang, Tony Jun

2014-01-01

Rapid and homogeneous mixing inside a microfluidic channel is demonstrated via the acoustic streaming phenomenon induced by the oscillation of sidewall sharp-edges. By optimizing the design of the sharp-edges, excellent mixing performance and fast mixing speed can be achieved in a simple device, making our sharp-edge-based acoustic micromixer a promising candidate for a wide variety of applications. PMID:23896797

SHARP User Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Y. Q.; Shemon, E. R.; Thomas, J. W.

SHARP is an advanced modeling and simulation toolkit for the analysis of nuclear reactors. It is comprised of several components including physical modeling tools, tools to integrate the physics codes for multi-physics analyses, and a set of tools to couple the codes within the MOAB framework. Physics modules currently include the neutronics code PROTEUS, the thermal-hydraulics code Nek5000, and the structural mechanics code Diablo. This manual focuses on performing multi-physics calculations with the SHARP ToolKit. Manuals for the three individual physics modules are available with the SHARP distribution to help the user to either carry out the primary multi-physics calculationmore » with basic knowledge or perform further advanced development with in-depth knowledge of these codes. This manual provides step-by-step instructions on employing SHARP, including how to download and install the code, how to build the drivers for a test case, how to perform a calculation and how to visualize the results. Since SHARP has some specific library and environment dependencies, it is highly recommended that the user read this manual prior to installing SHARP. Verification tests cases are included to check proper installation of each module. It is suggested that the new user should first follow the step-by-step instructions provided for a test problem in this manual to understand the basic procedure of using SHARP before using SHARP for his/her own analysis. Both reference output and scripts are provided along with the test cases in order to verify correct installation and execution of the SHARP package. At the end of this manual, detailed instructions are provided on how to create a new test case so that user can perform novel multi-physics calculations with SHARP. Frequently asked questions are listed at the end of this manual to help the user to troubleshoot issues.« less

The SMART Platform: early experience enabling substitutable applications for electronic health records

PubMed Central

Mandel, Joshua C; Murphy, Shawn N; Bernstam, Elmer Victor; Ramoni, Rachel L; Kreda, David A; McCoy, J Michael; Adida, Ben; Kohane, Isaac S

2012-01-01

Objective The Substitutable Medical Applications, Reusable Technologies (SMART) Platforms project seeks to develop a health information technology platform with substitutable applications (apps) constructed around core services. The authors believe this is a promising approach to driving down healthcare costs, supporting standards evolution, accommodating differences in care workflow, fostering competition in the market, and accelerating innovation. Materials and methods The Office of the National Coordinator for Health Information Technology, through the Strategic Health IT Advanced Research Projects (SHARP) Program, funds the project. The SMART team has focused on enabling the property of substitutability through an app programming interface leveraging web standards, presenting predictable data payloads, and abstracting away many details of enterprise health information technology systems. Containers—health information technology systems, such as electronic health records (EHR), personally controlled health records, and health information exchanges that use the SMART app programming interface or a portion of it—marshal data sources and present data simply, reliably, and consistently to apps. Results The SMART team has completed the first phase of the project (a) defining an app programming interface, (b) developing containers, and (c) producing a set of charter apps that showcase the system capabilities. A focal point of this phase was the SMART Apps Challenge, publicized by the White House, using http://www.challenge.gov website, and generating 15 app submissions with diverse functionality. Conclusion Key strategic decisions must be made about the most effective market for further disseminating SMART: existing market-leading EHR vendors, new entrants into the EHR market, or other stakeholders such as health information exchanges. PMID:22427539

New Academic Partnerships in Global Health: Innovations at Mount Sinai School of Medicine

PubMed Central

Landrigan, Philip J.; Ripp, Jonathan; Murphy, Ramon J. C.; Claudio, Luz; Jao, Jennifer; Hexom, Braden; Bloom, Harrison G.; Shirazian, Taraneh; Elahi, Ebby; Koplan, Jeffrey P.

2011-01-01

Global health has become an increasingly important focus of education, research, and clinical service in North American universities and academic health centers. Today there are at least 49 academically based global health programs in the United States and Canada, as compared with only one in 1999. A new academic society, the Consortium of Universities for Global Health, was established in 2008 and has grown significantly. This sharp expansion reflects convergence of 3 factors: (1) rapidly growing student and faculty interest in global health; (2) growing realization–powerfully catalyzed by the acquired immune deficiency syndrome epidemic, the emergence of other new infections, climate change, and globalization–that health problems are interconnected, cross national borders, and are global in nature; and (3) rapid expansion in resources for global health. This article examines the evolution of the concept of global health and describes the driving forces that have accelerated interest in the field. It traces the development of global health programs in academic health centers in the United States. It presents a blueprint for a new school-wide global health program at Mount Sinai School of Medicine. The mission of that program, Mount Sinai Global Health, is to enhance global health as an academic field of study within the Mount Sinai community and to improve the health of people around the world. Mount Sinai Global Health is uniting and building synergies among strong, existing global health programs within Mount Sinai; it is training the next generation of physicians and health scientists to be leaders in global health; it is making novel discoveries that translate into blueprints for improving health worldwide; and it builds on Mount Sinai’s long and proud tradition of providing medical and surgical care in places where need is great and resources few. PMID:21598272

Microstructural and hardness investigations on a dissimilar metal weld between low alloy steel and Alloy 82 weld metal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Z.R., E-mail: raymix@aliyun.com

The investigation on microstructure and hardness at the fusion boundary (FB) region of a dissimilar metal weld (DMW) between low alloy steel (LAS) A508-III and Alloy 82 weld metal (WM) was carried out. The results indicated that there were two kinds of FBs, martensite FB and sharp FB, with obvious different microstructures, alternately distributed in the same FB. The martensite FB region had a gradual change of elemental concentration across FB, columnar WM grains with high length/width ratios, a thick martensite layer and a wide heat affected zone (HAZ) with large prior austenite grains. By comparison, the sharp FB regionmore » had a relatively sharp change of elemental concentration across the FB, WM grains with low length/width ratios and a narrow HAZ with smaller prior austenite grains. The martensite possessed a K-S orientation relationship with WM grains, while no orientation relationship was found between the HAZ grains and WM grains at the sharp FB. Compared with sharp FB there were much more Σ3 boundaries in the HAZ beside martensite FB. The hardness maximum of the martensite FB was much higher than that of the sharp FB, which was attributed to the martensite layer at the martensite FB. - Highlights: •Martensite and sharp FBs with different microstructures were found in the same FB. •There were high length/width-ratio WM grains and a wide HAZ beside martensite FB. •There were low length/width-ratio WM grains and a narrow HAZ beside sharp FB. •Compared with sharp FB, there were much more Σ3 boundaries in HAZ of martensite FB. •Hardness maximium of martensite FB was much higher than that of sharp FB.« less

Predicting changes in drug use and treatment entry for local programs: a case study.

PubMed

Flaherty, E W; Olsen, K; Bencivengo, M

1980-01-01

Recent sharp decline in treatment admissions by opiate abusers stimulated the conduct of a study designed to provide timely data to treatment system administrators for the next cycle of program and budgetary planning. The process of designing the study involved definition of required study characteristics, review of four categories of drug abuse research, and generation of seven locally relevant hypotheses. Interviews were conducted with 335 heroin adicts: 196 new admissions to treatment and 139 "street" addicts not currently in treatment. Major findings were a marked reduction in the quality, availability, and price of heroin; very negative perceptions of methadone maintenance, especially by female respondents; decline in heroin popularity and increase in reported use of alcohol, amphetamines, and barbiturates; and differing perceptions of treatment by sex of respondent. Response patterns suggest that users who are not entering treatment are less "strung-out than those entering treatment because of decline in availability and quality of heroin and consequent increased mixing of drugs. The emphasis in the report is on the conduct of a study which can be timely, feasible, and useful to local planners. The study weaknesses and recommended remedies are discussed, as well as the characteristics which made the findings immediately useful to administrators and planners.

Notes on breeding sharp-shinned hawks and cooper’s hawks in Barnwell County, South Carolina

Treesearch

Mark Vukovich; John C. Kilgo

2009-01-01

Breeding records of Accipiter striatus (Sharp-shinned Hawks) in the southeastern US are scattered and isolated. We documented a Sharp-shinned Hawk and Accipiter cooperii (Cooper’s Hawk) nest while conducting a telemetry study on Melanerpes erythrocephalus (Red-headed Woodpeckers) in Barnwell County, SC in 2006 and 2007. We report the first known nest of a Sharp-shinned...

Edge Sharpness Assessment by Parametric Modeling: Application to Magnetic Resonance Imaging.

PubMed

Ahmad, R; Ding, Y; Simonetti, O P

2015-05-01

In biomedical imaging, edge sharpness is an important yet often overlooked image quality metric. In this work, a semi-automatic method to quantify edge sharpness in the presence of significant noise is presented with application to magnetic resonance imaging (MRI). The method is based on parametric modeling of image edges. First, an edge map is automatically generated and one or more edges-of-interest (EOI) are manually selected using graphical user interface. Multiple exclusion criteria are then enforced to eliminate edge pixels that are potentially not suitable for sharpness assessment. Second, at each pixel of the EOI, an image intensity profile is read along a small line segment that runs locally normal to the EOI. Third, the profiles corresponding to all EOI pixels are individually fitted with a sigmoid function characterized by four parameters, including one that represents edge sharpness. Last, the distribution of the sharpness parameter is used to quantify edge sharpness. For validation, the method is applied to simulated data as well as MRI data from both phantom imaging and cine imaging experiments. This method allows for fast, quantitative evaluation of edge sharpness even in images with poor signal-to-noise ratio. Although the utility of this method is demonstrated for MRI, it can be adapted for other medical imaging applications.

S-HARP: A parallel dynamic spectral partitioner

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sohn, A.; Simon, H.

1998-01-01

Computational science problems with adaptive meshes involve dynamic load balancing when implemented on parallel machines. This dynamic load balancing requires fast partitioning of computational meshes at run time. The authors present in this report a fast parallel dynamic partitioner, called S-HARP. The underlying principles of S-HARP are the fast feature of inertial partitioning and the quality feature of spectral partitioning. S-HARP partitions a graph from scratch, requiring no partition information from previous iterations. Two types of parallelism have been exploited in S-HARP, fine grain loop level parallelism and coarse grain recursive parallelism. The parallel partitioner has been implemented in Messagemore » Passing Interface on Cray T3E and IBM SP2 for portability. Experimental results indicate that S-HARP can partition a mesh of over 100,000 vertices into 256 partitions in 0.2 seconds on a 64 processor Cray T3E. S-HARP is much more scalable than other dynamic partitioners, giving over 15 fold speedup on 64 processors while ParaMeTiS1.0 gives a few fold speedup. Experimental results demonstrate that S-HARP is three to 10 times faster than the dynamic partitioners ParaMeTiS and Jostle on six computational meshes of size over 100,000 vertices.« less

Cognition-Emotion Interaction as a Predictor of Adolescent Depressive Symptoms

ERIC Educational Resources Information Center

Rudolph, Karen D.; Davis, Megan M.; Monti, Jennifer D.

2017-01-01

Given the sharp increase in rates of depression during adolescence, especially in girls, it is important to identify which youth are at greatest risk across this critical developmental transition. During the present research, we examined whether (a) individual differences in cognition-emotion interaction, as reflected in cognitive control (CC)…

Healthcare Personnel's Use of E-Information Sources in Riyadh Governmental Hospitals

ERIC Educational Resources Information Center

Khudair, Ahmad A.; Cooke, Louise

2008-01-01

ICT has enabled a wide dissemination of information and a sharp increase in the magnitude of electronic information sources. The use of e-information sources by healthcare personnel within Saudi Arabia has received little research attention. This paper discusses the use of e-information sources by healthcare personnel in the kingdom. A…

Focused Group Interviews as an Innovative Quanti-Qualitative Methodology (QQM): Integrating Quantitative Elements into a Qualitative Methodology

ERIC Educational Resources Information Center

Grim, Brian J.; Harmon, Alison H.; Gromis, Judy C.

2006-01-01

There is a sharp divide between quantitative and qualitative methodologies in the social sciences. We investigate an innovative way to bridge this gap that incorporates quantitative techniques into a qualitative method, the "quanti-qualitative method" (QQM). Specifically, our research utilized small survey questionnaires and experiment-like…

Research Journal Prices--Trends and Problems. Update. CRS Report for Congress.

ERIC Educational Resources Information Center

Rowberg, Richard E.

This report highlights the trends and problems associated with rapid price increases of foreign-published journals, especially science and technology journals. It is observed that a combination of effects--e.g., discriminatory pricing on the part of some foreign publishers, the sharp decline of the U.S. dollar--have resulted in subscription…

The Experiences of Disabled Pupils and Their Families

ERIC Educational Resources Information Center

Lewis, Ann; Davison, Ian; Ellins, Jean; Niblett, Louise; Parsons, Sarah; Robertson, Christopher; Sharpe, Jeremy

2007-01-01

In this article, Ann Lewis, Professor of Education at the University of Birmingham, and Ian Davison, Jean Ellins, Louise Niblett, Sarah Parsons, Christopher Robertson and Jeremy Sharpe from the research team provide a summary of discussions and selected recommendations arising from four linked projects run between 2004 and 2006. The projects were…

A sharp image or a sharp knife: norms for the modality-exclusivity of 774 concept-property items.

PubMed

van Dantzig, Saskia; Cowell, Rosemary A; Zeelenberg, René; Pecher, Diane

2011-03-01

According to recent embodied cognition theories, mental concepts are represented by modality-specific sensory-motor systems. Much of the evidence for modality-specificity in conceptual processing comes from the property-verification task. When applying this and other tasks, it is important to select items based on their modality-exclusivity. We collected modality ratings for a set of 387 properties, each of which was paired with two different concepts, yielding a total of 774 concept-property items. For each item, participants rated the degree to which the property could be experienced through five perceptual modalities (vision, audition, touch, smell, and taste). Based on these ratings, we computed a measure of modality exclusivity, the degree to which a property is perceived exclusively through one sensory modality. In this paper, we briefly sketch the theoretical background of conceptual knowledge, discuss the use of the property-verification task in cognitive research, provide our norms and statistics, and validate the norms in a memory experiment. We conclude that our norms are important for researchers studying modality-specific effects in conceptual processing.

Microsoft C#.NET program and electromagnetic depth sounding for large loop source

NASA Astrophysics Data System (ADS)

Prabhakar Rao, K.; Ashok Babu, G.

2009-07-01

A program, in the C# (C Sharp) language with Microsoft.NET Framework, is developed to compute the normalized vertical magnetic field of a horizontal rectangular loop source placed on the surface of an n-layered earth. The field can be calculated either inside or outside the loop. Five C# classes with member functions in each class are, designed to compute the kernel, Hankel transform integral, coefficients for cubic spline interpolation between computed values and the normalized vertical magnetic field. The program computes the vertical magnetic field in the frequency domain using the integral expressions evaluated by a combination of straightforward numerical integration and the digital filter technique. The code utilizes different object-oriented programming (OOP) features. It finally computes the amplitude and phase of the normalized vertical magnetic field. The computed results are presented for geometric and parametric soundings. The code is developed in Microsoft.NET visual studio 2003 and uses various system class libraries.

Needle Stick Injuries, Sharp Injuries and other Occupational Exposures to Blood and Body Fluids among Health Care Workers in a general hospital in Sarajevo, Bosnia and Herzegovina.

PubMed

Musa, Sanjin; Peek-Asa, Corinne; Young, Tracy; Jovanovic, Nina

2014-01-01

Health Professional exposures of health care workers (HCW) to potentially infective blood and body fluids presents a serious health threat, including hepatitis B, hepatitis C and HIV transmission. This study was conducted to assess the risk for and reporting of needle stick injuries, sharp injuries and other occupational exposures of health care workers in a large healthcare center in Sarajevo. This cross-sectional survey was conducted in May 2013. The study target population included all hospital health care workers who had a high potential for exposure. The estimated sample size was 48 physicians, 132 nurses/technicians and 30 auxiliary personnel. During their career, 124 (63.3%) HCW reported exposures to blood and body fluids. In total, needle stick injuries (66.1%) were the most common source of exposure, followed by contact with intact skin (12.1%) and cut with sharp object (11.3%). Only 43 (35.5%) reported any of these exposures to health authorities during their career. The odds of exposure to needle stick injuries and other occupational exposures to blood and bodily fluids were significantly higher among medical nurses/technicians (AOR=4.98, 95%CI=1.52-16,1) and auxiliary (AOR=4.30, 95% CI=1.07-17.34) personnel when compared to physicians. HCW in the operation room, intervention ambulance and laboratory (AOR=3.73, 95%CI=1.43-9.72) had higher odds of exposure than workers in the ambulatory departments. Needle stick Injuries, Sharp Injuries and other Occupational Exposures to Blood and Body Fluids among health care workers are underestimated hazard. Especially, for HCW who work in operation room/interventional ambulance. There is a need for preventive programs for HCW and further work on the establishment of an effective surveillance system.

Induction of the SHARP-2 mRNA level by insulin is mediated by multiple signaling pathways.

PubMed

Kanai, Yukiko; Asano, Kosuke; Komatsu, Yoshiko; Takagi, Katsuhiro; Ono, Moe; Tanaka, Takashi; Tomita, Koji; Haneishi, Ayumi; Tsukada, Akiko; Yamada, Kazuya

2017-02-01

The rat enhancer of split- and hairy-related protein-2 (SHARP-2) is an insulin-inducible transcription factor which represses transcription of the rat phosphoenolpyruvate carboxykinase gene. In this study, a regulatory mechanism of the SHARP-2 mRNA level by insulin was analyzed. Insulin rapidly induced the level of SHARP-2 mRNA. This induction was blocked by inhibitors for phosphoinositide 3-kinase (PI 3-K), protein kinase C (PKC), and mammalian target of rapamycin (mTOR), actinomycin D, and cycloheximide. Whereas an adenovirus infection expressing a dominant negative form of atypical PKC lambda (aPKCλ) blocked the insulin-induction of the SHARP-2 mRNA level, insulin rapidly activated the mTOR. Insulin did not enhance transcriptional activity from a 3.7 kb upstream region of the rat SHARP-2 gene. Thus, we conclude that insulin induces the expression of the rat SHARP-2 gene at the transcription level via both a PI 3-K/aPKCλ- and a PI 3-K/mTOR- pathways and that protein synthesis is required for this induction.

Audit of sharp weapon deaths in metropolis of Karachi--an autopsy based study.

PubMed

Mirza, Farhat Hussain; Hasan, Qudsia; Memon, Akhtar Amin; Adil, Syeda Ezz-e-Rukhshan

2010-01-01

Sharp weapons are one of the most violent and abhorrent means of deaths. This study assesses the frequency of sharp weapon deaths in Karachi. This was a cross sectional study, and involves the deaths by sharp weapons autopsied in Karachi during Mar 2008-Feb 2009. This study reports that the frequency of sharp weapon deaths in Karachi is similar to some other studies conducted in different regions of Pakistan, yet it is very high as the population of Karachi is way more than any other metropolis of Pakistan. Our study reported that out of 2090 medico-legal deaths in Karachi during the study period, 91 deaths were due to sharp weapons, including 73 (80.2%) males and 18 (19.8%) females. 100% of the deaths were homicides, so none were suicides. Deaths were more frequent in age group ranging from 20-39 years (59.3%). Sharp weapon deaths continue to be a means of quite a number of deaths in Karachi. Such violence depicts intolerant and frustrated nature of the citizens.

Sparse Recovery via Differential Inclusions

DTIC Science & Technology

2014-07-01

2242. [Wai09] Martin J. Wainwright, Sharp thresholds for high-dimensional and noisy spar- sity recovery using l1 -constrained quadratic programming...solution, (1.11) βt = { 0, if t < 1/y; y(1− e−κ(t−1/y)), otherwise, which converges to the unbiased Bregman ISS estimator exponentially fast. Let us ...are not given the support set S, so the following two prop- erties are used to evaluate the performance of an estimator β̂. 1. Model selection

Picturing Video

NASA Technical Reports Server (NTRS)

2000-01-01

Video Pics is a software program that generates high-quality photos from video. The software was developed under an SBIR contract with Marshall Space Flight Center by Redhawk Vision, Inc.--a subsidiary of Irvine Sensors Corporation. Video Pics takes information content from multiple frames of video and enhances the resolution of a selected frame. The resulting image has enhanced sharpness and clarity like that of a 35 mm photo. The images are generated as digital files and are compatible with image editing software.

Susceptibility, Oviposition Preference, and Biology of Grapholita molesta (Lepidoptera: Tortricidae) in Prunus Spp. Rootstock Genotypes.

PubMed

Bernardi, D; Lazzari, J C; Andreazza, F; Mayer, N A; Botton, M; Nava, D E

2017-08-01

Studying the susceptibility of peach trees to Grapholita molesta (Busck) is one of the major steps in the development of pest-resistant peach varieties. This work evaluated the susceptibility of 55 genotypes of the "Prunus Rootstock Collection" ("Coleção Porta-enxerto de Prunus") of Embrapa Temperate Climate (Pelotas, Rio Grande do Sul, Brazil) to the natural infestation of G. molesta, assessed the oviposition preference of G. molesta in choice and no-choice bioassays, and estimated the biological parameters and the fertility life table on different Prunus spp. genotypes in the laboratory. Genotypes Prunus kansuensis (Rehder), I-67-52-9, and I-67-52-4 were the most susceptible to G. molesta infestation in the field (>60% of branches infested), while 'Sharpe' (Prunus angustifolia x Prunus spp.) and Prunus sellowii (Koehne) were the least infested (0% of branches infested). In choice and no-choice bioassays, G. molesta preferred to oviposit on P. kansuensis when compared with Sharpe. The Sharpe genotype also showed an antibiosis effect, resulting in negative effects on the fertility life table parameters when compared with the genotypes P. kansuensis and 'Capdeboscq.' The results found in the present study can provide information to initiate a long-term breeding program moving desired G. molesta resistance traits from the rootstock into the Prunus spp. cultivars. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Sumoylation of the Basic Helix-Loop-Helix Transcription Factor Sharp-1 Regulates Recruitment of the Histone Methyltransferase G9a and Function in Myogenesis*

PubMed Central

Wang, Yaju; Shankar, Shilpa Rani; Kher, Devaki; Ling, Belinda Mei Tze; Taneja, Reshma

2013-01-01

Sumoylation is an important post-translational modification that alters the activity of many transcription factors. However, the mechanisms that link sumoylation to alterations in chromatin structure, which culminate in tissue specific gene expression, are not fully understood. In this study, we demonstrate that SUMO modification of the transcription factor Sharp-1 is required for its full transcriptional repression activity and function as an inhibitor of skeletal muscle differentiation. Sharp-1 is modified by sumoylation at two conserved lysine residues 240 and 255. Mutation of these SUMO acceptor sites in Sharp-1 does not impact its subcellular localization but attenuates its ability to act as a transcriptional repressor and inhibit myogenic differentiation. Consistently, co-expression of the SUMO protease SENP1 with wild type Sharp-1 abrogates Sharp-1-dependent inhibition of myogenesis. Interestingly, sumoylation acts as a signal for recruitment of the co-repressor G9a. Thus, enrichment of G9a, and histone H3 lysine 9 dimethylation (H3K9me2), a signature of G9a activity, is dramatically reduced at muscle promoters in cells expressing sumoylation-defective Sharp-1. Our findings demonstrate how sumoylation of Sharp-1 exerts an impact on chromatin structure and transcriptional repression of muscle gene expression through recruitment of G9a. PMID:23637228

Confirmation of the Factor Structure and Measurement Invariance of the Children's Scale of Hostility and Aggression: Reactive/Proactive in Clinic-Referred Children With and Without Autism Spectrum Disorder.

PubMed

Farmer, Cristan A; Kaat, Aaron J; Mazurek, Micah O; Lainhart, Janet E; DeWitt, Mary Beth; Cook, Edwin H; Butter, Eric M; Aman, Michael G

2016-02-01

The measurement of aggression in its different forms (e.g., physical and verbal) and functions (e.g., impulsive and instrumental) is given little attention in subjects with developmental disabilities (DD). In this study, we confirm the factor structure of the Children's Scale for Hostility and Aggression: Reactive/Proactive (C-SHARP) and demonstrate measurement invariance (consistent performance across clinical groups) between clinic-referred groups with and without autism spectrum disorder (ASD). We also provide evidence of the construct validity of the C-SHARP. Caregivers provided C-SHARP, Child Behavior Checklist (CBCL), and Proactive/Reactive Rating Scale (PRRS) ratings for 644 children, adolescents, and young adults 2-21 years of age. Five types of measurement invariance were evaluated within a confirmatory factor analytic framework. Associations among the C-SHARP, CBCL, and PRRS were explored. The factor structure of the C-SHARP had a good fit to the data from both groups, and strict measurement invariance between ASD and non-ASD groups was demonstrated (i.e., equivalent structure, factor loadings, item intercepts and residuals, and latent variance/covariance between groups). The C-SHARP Problem Scale was more strongly associated with CBCL Externalizing than with CBCL Internalizing, supporting its construct validity. Subjects classified with the PRRS as both Reactive and Proactive had significantly higher C-SHARP Proactive Scores than those classified as Reactive only, who were rated significantly higher than those classified by the PRRS as Neither Reactive nor Proactive. A similar pattern was observed for the C-SHARP Reactive Score. This study provided evidence of the validity of the C-SHARP through confirmation of its factor structure and its relationship with more established scales. The demonstration of measurement invariance demonstrates that differences in C-SHARP factor scores were the result of differences in the construct rather than to error or unmeasured/nuisance variables. These data suggest that the C-SHARP is useful for quantifying subtypes of aggressive behavior in children, adolescents, and young adults with DD.

Machinery safety of lathe machine using SHARP-systemic human action reliability procedure: a pilot case study in academic laboratory

NASA Astrophysics Data System (ADS)

Suryoputro, M. R.; Sari, A. D.; Sugarindra, M.; Arifin, R.

2017-12-01

This research aimed to understand the human reliability analysis, to find the SHARP method with its functionality on case study and also emphasize the practice in Lathe machine, continued with identifying improvement that could be made to the existing safety system. SHARP comprises of 7 stages including definition, screening, breakdown, representation, impact assessment, quantification and documentation. These steps were combined and analysed using HIRA, FTA and FMEA. HIRA analysed the lathe at academic laboratory showed the level of the highest risk with a score of 9 for the activities of power transmission parts and a score of 6 for activities which shall mean the moving parts required to take action to reduce the level of risk. Hence, the highest RPN values obtained in the power transmission activities with a value of 18 in the power transmission and then the activities of moving parts is 12 and the activities of the operating point of 8. Thus, this activity has the highest risk of workplace accidents in the operation. On the academic laboratory the improvement made on the engineering control initially with a machine guarding and completed with necessary administrative controls (SOP, work permit, training and routine cleaning) and dedicated PPEs.

Simulation-Based Analysis of Reentry Dynamics for the Sharp Atmospheric Entry Vehicle

NASA Technical Reports Server (NTRS)

Tillier, Clemens Emmanuel

1998-01-01

This thesis describes the analysis of the reentry dynamics of a high-performance lifting atmospheric entry vehicle through numerical simulation tools. The vehicle, named SHARP, is currently being developed by the Thermal Protection Materials and Systems branch of NASA Ames Research Center, Moffett Field, California. The goal of this project is to provide insight into trajectory tradeoffs and vehicle dynamics using simulation tools that are powerful, flexible, user-friendly and inexpensive. Implemented Using MATLAB and SIMULINK, these tools are developed with an eye towards further use in the conceptual design of the SHARP vehicle's trajectory and flight control systems. A trajectory simulator is used to quantify the entry capabilities of the vehicle subject to various operational constraints. Using an aerodynamic database computed by NASA and a model of the earth, the simulator generates the vehicle trajectory in three-dimensional space based on aerodynamic angle inputs. Requirements for entry along the SHARP aerothermal performance constraint are evaluated for different control strategies. Effect of vehicle mass on entry parameters is investigated, and the cross range capability of the vehicle is evaluated. Trajectory results are presented and interpreted. A six degree of freedom simulator builds on the trajectory simulator and provides attitude simulation for future entry controls development. A Newtonian aerodynamic model including control surfaces and a mass model are developed. A visualization tool for interpreting simulation results is described. Control surfaces are roughly sized. A simple controller is developed to fly the vehicle along its aerothermal performance constraint using aerodynamic flaps for control. This end-to-end demonstration proves the suitability of the 6-DOF simulator for future flight control system development. Finally, issues surrounding real-time simulation with hardware in the loop are discussed.

Buscando Trabajo: Social Networking among Immigrants from Mexico to the United States

ERIC Educational Resources Information Center

Garcia, Carlos

2005-01-01

The growth of the Latino population in the United States has placed a sharp focus on immigration. Previous research on immigration has taken for granted the existence of immigrant networks. This is a significant oversight given their importance in both conveying social capital and their contribution to the growth of immigrant communities. Using…

Education: Past, Present and Future Global Challenges. Policy Research Working Paper 5616

ERIC Educational Resources Information Center

Patrinos, Harry Anthony; Psacharopoulos, George

2011-01-01

Progress in educational development in the world since 1900 has been slow and uneven between countries. Providing basic education for all children in developing countries has been and remains an unmet challenge of governments and international organizations alike. This is in sharp contrast to recent findings in the economics literature on the…

A New Classification Scheme for For-Profit Institutions

ERIC Educational Resources Information Center

Institute for Higher Education Policy, 2012

2012-01-01

For-profit institutions are more visible today among policymakers, researchers, and investors, due in large part to the sharp rise in the number of students attending them over the last decade. From 2000 to 2009, enrollment in the for-profit sector tripled while enrollment in the public and not-for-profit sectors increased by less than 25 percent.…

ADHD Delays, Rather Than Alters, Brain Development. Science Briefs

ERIC Educational Resources Information Center

National Scientific Council on the Developing Child, 2008

2008-01-01

"Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This brief reports on the study "Attention-deficit/Hyperactivity Disorder is Characterized by a Delay in Cortical Maturation" (P. Shaw; K. Eckstrand; W. Sharp; J. Blumenthal; J. P. Lerch; D. Greenstein; L. Clasen; A. Evans; J. Giedd;…

A Forced but Passionate Marriage: The Changing Relationship between Past and Present in Dutch History Education 1945-1979

ERIC Educational Resources Information Center

Albicher, Alexander

2012-01-01

Although the history of history education is an under-researched topic worldwide, the international literature about history education contains a clear image of the historical development of the school subject. This image basically consists of a sharp dichotomy between traditional history education, which was largely insensitive to topical affairs…

Doing Much More with Less: Implementing Operational Excellence at UC Berkeley. Research & Occasional Paper Series: CSHE.10.13

ERIC Educational Resources Information Center

Szeri, Andrew J.; Lyons, Richard; Huston, Peggy; Wilton, John

2013-01-01

Universities are undergoing historic change, from the sharp downward shift in government funding to widespread demands to document performance. At the University of California Berkeley, this led to an operational change effort unlike any the university had ever attempted, dubbed Operational Excellence. The authors describe their experiences…

75 FR 70915 - Intent To Grant an Exclusive License for a U.S. Government-Owned Invention

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... Vaccine, Methods of Making and Use Thereof,'' to Merck Sharp & Dohme Corp., with its principal place of business at One Merck Drive, Whitehouse Station, NJ 08889-3400. ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, ATTN: Command Judge Advocate, MCMR-JA, 504 Scott Street, Fort Detrick...

Sharp Focus on Film; A Brief Guide to Research on Movies and Movie People.

ERIC Educational Resources Information Center

Smith, Phil; Sasse, Margo

An attempt to increase individuals' sophistication in finding information about movies is made in this guide. Strategies to uncover reviews, criticism, biographies and other film data in the University of California at San Diego libraries are outlined. The first major section deals with approaches to the card catalog and suggests ways of getting…

The "Insider" Principal: Perceptions of the Leadership Effectiveness of an Internal Successor

ERIC Educational Resources Information Center

Rivera-McCutchen, Rosa L.

2014-01-01

The current study builds on earlier leader succession research, focusing on a school where the "insider"--who was believed to be strong before being hired as the formal school leader--drew sharp criticism after assuming the principalship. Interviews with staff members who worked with the insider leader in her role as teacher and…

High-angular-resolution NIR astronomy with large arrays (SHARP I and SHARP II)

NASA Astrophysics Data System (ADS)

Hofmann, Reiner; Brandl, Bernhard; Eckart, Andreas; Eisenhauer, Frank; Tacconi-Garman, Lowell E.

1995-06-01

SHARP I and SHARP II are near infrared cameras for high-angular-resolution imaging. Both cameras are built around a 256 X 256 pixel NICMOS 3 HgCdTe array from Rockwell which is sensitive in the 1 - 2.5 micrometers range. With a 0.05'/pixel scale, they can produce diffraction limited K-band images at 4-m-class telescopes. For a 256 X 256 array, this pixel scale results in a field of view of 12.8' X 12.8' which is well suited for the observation of galactic and extragalactic near-infrared sources. Photometric and low resolution spectroscopic capabilities are added by photometric band filters (J, H, K), narrow band filters ((lambda) /(Delta) (lambda) approximately equals 100) for selected spectral lines, and a CVF ((lambda) /(Delta) (lambda) approximately equals 70). A cold shutter permits short exposure times down to about 10 ms. The data acquisition electronics permanently accepts the maximum frame rate of 8 Hz which is defined by the detector time constants (data rate 1 Mbyte/s). SHARP I has been especially designed for speckle observations at ESO's 3.5 m New Technology Telescope and is in operation since 1991. SHARP II is used at ESO's 3.6 m telescope together with the adaptive optics system COME-ON + since 1993. A new version of SHARP II is presently under test, which incorporates exchangeable camera optics for observations with scales of 0.035, 0.05, and 0.1'/pixel. The first scale extends diffraction limited observations down to the J-band, while the last one provides a larger field of view. To demonstrate the power of the cameras, images of the galactic center obtained with SHARP I, and images of the R136 region in 30 Doradus observed with SHARP II are presented.

The risk of capsular breakage from phacoemulsification needle contact with the lens capsule: a laboratory study.

PubMed

Meyer, Jay J; Kuo, Annie F; Olson, Randall J

2010-06-01

To determine capsular breakage risk from contact by phacoemulsification needles by machine and tip type. Experimental laboratory investigation. Infiniti (Alcon, Inc.) with Intrepid cartridges and Signature (Abbott Medical Optics, Inc.) phacoemulsification machines were tested using 19- and 20-gauge sharp and rounded tips. Actual and unoccluded flow vacuum were determined at 550 mm Hg, bottle height of 75 cm, and machine-indicated flow rate of 60 mL/minute. Breakage from brief tip contact with a capsular surrogate and human cadaveric lenses was calculated. Nineteen-gauge tips had more flow and less unoccluded flow vacuum than 20-gauge tips for both machines, with highest unoccluded flow vacuum in the Infiniti. The 19-gauge sharp tip was more likely than the 20-gauge sharp tip to cause surrogate breakage for Signature with micropulse and Ellips (Abbott Medical Optics, Inc.) ultrasound at 100% power. For Infiniti using OZil (Alcon, Inc.) ultrasound, 20-gauge sharp tips were more likely than 19-gauge sharp tips to break the membrane. For cadaveric lenses, using rounded 20-gauge tips at 100% power, breakage rates were micropulse (2.3%), Ellips (2.3%), OZil (5.3%). Breakage rates for sharp 20-gauge Ellips tips were higher than for rounded tips. Factors influencing capsular breakage may include active vacuum at the tip, flow rate, needle gauge, and sharpness. Nineteen-gauge sharp tips were more likely than 20-gauge tips to cause breakage in lower vacuum methods. For higher-vacuum methods, breakage is more likely with 20-gauge than with 19-gauge tips. Rounded-edge tips are less likely than sharp-edged tips to cause breakage. Copyright 2010 Elsevier Inc. All rights reserved.

SHARP Multiphysics Tutorials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Y. Q.; Shemon, E. R.; Mahadevan, Vijay S.

SHARP, developed under the NEAMS Reactor Product Line, is an advanced modeling and simulation toolkit for the analysis of advanced nuclear reactors. SHARP is comprised of three physics modules currently including neutronics, thermal hydraulics, and structural mechanics. SHARP empowers designers to produce accurate results for modeling physical phenomena that have been identified as important for nuclear reactor analysis. SHARP can use existing physics codes and take advantage of existing infrastructure capabilities in the MOAB framework and the coupling driver/solver library, the Coupled Physics Environment (CouPE), which utilizes the widely used, scalable PETSc library. This report aims at identifying the coupled-physicsmore » simulation capability of SHARP by introducing the demonstration example called sahex in advance of the SHARP release expected by Mar 2016. sahex consists of 6 fuel pins with cladding, 1 control rod, sodium coolant and an outer duct wall that encloses all the other components. This example is carefully chosen to demonstrate the proof of concept for solving more complex demonstration examples such as EBR II assembly and ABTR full core. The workflow of preparing the input files, running the case and analyzing the results is demonstrated in this report. Moreover, an extension of the sahex model called sahex_core, which adds six homogenized neighboring assemblies to the full heterogeneous sahex model, is presented to test homogenization capabilities in both Nek5000 and PROTEUS. Some primary information on the configuration and build aspects for the SHARP toolkit, which includes capability to auto-download dependencies and configure/install with optimal flags in an architecture-aware fashion, is also covered by this report. A step-by-step instruction is provided to help users to create their cases. Details on these processes will be provided in the SHARP user manual that will accompany the first release.« less

National Dam Safety Program. Bayman Dam - No Name 381 (MO 20240), Missouri - Kansas City Basin, Jackson County, Missouri. Phase I Inspection Report.

DTIC Science & Technology

1978-08-01

broad - crested weir equation and the sharp crested circular... weir equation. Broad - crested weir equation: Q = CLH 1 .5 (C = varies, L = varies, H is the head on weir ). Circular weir equation: Q = C0 2rR (H0 )5 (C0...the toe of the downstream embankment. The spillway inlet is about 25 feet upstream of the crest of the dam. (3) Pertinent physical data are given

Smartphone Microscopy of Parasite Eggs Accumulated into a Single Field of View

PubMed Central

Sowerby, Stephen J.; Crump, John A.; Johnstone, Maree C.; Krause, Kurt L.; Hill, Philip C.

2016-01-01

A Nokia Lumia 1020 cellular phone (Microsoft Corp., Auckland, New Zealand) was configured to image the ova of Ascaris lumbricoides converged into a single field of view but on different focal planes. The phone was programmed to acquire images at different distances and, using public domain computer software, composite images were created that brought all the eggs into sharp focus. This proof of concept informs a framework for field-deployable, point of care monitoring of soil-transmitted helminths. PMID:26572870

Maintaining knife sharpness in industrial meat cutting: A matter of knife or meat cutter ability.

PubMed

Karltun, J; Vogel, K; Bergstrand, M; Eklund, J

2016-09-01

Knife sharpness is imperative in meat cutting. The aim of this study was to compare the impact of knife blade steel quality with meat cutters' individual ability to maintain the cutting edge sharp in an industrial production setting. Twelve meat cutters in two different companies using three different knives during normal production were studied in this quasi-experimental study. Methods included were measuring knife cutting force before and after knife use, time knives were used, ratings of sharpness and discomfort and interviews. Results showed that the meat cutters' skill of maintaining sharpness during work had a much larger effect on knife sharpness during work than the knife steel differences. The ability was also related to feelings of discomfort and to physical exertion. It was found that meat cutters using more knives were more likely to suffer from discomfort in the upper limbs, which is a risk for developing MSD. Copyright © 2016 Elsevier Ltd. All rights reserved.

Weapon Use in Korean Homicide: Differences Between Homicides Involving Sharp and Blunt Instruments.

PubMed

Park, Jisun; Son, Hyeonseo

2017-10-23

On the basis of information regarding 276 homicides committed in South Korea between 1987 and 2008, we compared offenders' and victims' characteristics, injury locations, weapon-related behavior, and offending behavior between homicides involving sharp and blunt instruments. The victims of sharp-force homicide were much younger relative to those of blunt-force homicide. In addition, homicides involving blunt instruments were more likely to be committed by offenders who lived with the victims. Most sharp-force homicides involved injuries to the torso, while blunt-force homicides involved mainly head injuries. Furthermore, perpetrators of sharp-force homicides tended to preselect their weapons, while those of blunt-force homicides were likely to use weapons of opportunity. Logistic regression analysis identified a number of factors, including injury location and body transportation, which significantly predicted weapon type. As this was the first South Korean study to compare sharp- and blunt-force homicides, the results have practical implications for homicide investigations. © 2017 American Academy of Forensic Sciences.

Improvement in perception of image sharpness through the addition of noise and its relationship with memory texture

NASA Astrophysics Data System (ADS)

Wan, Xiazi; Kobayashi, Hiroyuki; Aoki, Naokazu

2015-03-01

In a preceding study, we investigated the effects of image noise on the perception of image sharpness using white noise, and one- and two-dimensional single-frequency sinusoidal patterns as stimuli. This study extends our preceding study by evaluating natural color images, rather than black-and-white patterns. The results showed that the effect of noise in improving image sharpness perception is more evident in blurred images than in sharp images. This is consistent with the results of the preceding study. In another preceding study, we proposed "memory texture" to explain the preferred granularity of images, as a concept similar to "memory color" for preferred color reproduction. We observed individual differences in type of memory texture for each object, that is, white or 1/f noise. This study discusses the relationship between improvement of sharpness perception by adding noise, and the memory texture, following its individual differences. We found that memory texture is one of the elements that affect sharpness perception.

Timbral Sharpness and Modulations in Frequency and Amplitude: Implications for the Fusion of Musical Sounds.

NASA Astrophysics Data System (ADS)

Goad, Pamela Joy

The fusion of musical voices is an important aspect of musical blend, or the mixing of individual sounds. Yet, little research has been done to explicitly determine the factors involved in fusion. In this study, the similarity of timbre and modulation were examined for their contribution to the fusion of sounds. It is hypothesized that similar timbres will fuse better than dissimilar timbres, and, voices with the same kind of modulation will fuse better than voices of different modulations. A perceptually-based measure, known as sharpness was investigated as a measure of timbre. The advantages of using sharpness are that it is based on hearing sensitivities and masking phenomena of inner ear processing. Five musical instrument families were digitally recorded in performances across a typical playing range at two extreme dynamic levels. Analyses reveal that sharpness is capable of uncovering subtle changes in timbre including those found in musical dynamics, instrument design, and performer-specific variations. While these analyses alone are insufficient to address fusion, preliminary calculations of timbral combinations indicate that sharpness has the potential to predict the fusion of sounds used in musical composition. Three experiments investigated the effects of modulation on the fusion of a harmonic major sixth interval. In the first experiment using frequency modulation, stimuli varied in deviation about a mean fundamental frequency and relative modulation phase between the two tones. Results showed smaller frequency deviations promoted fusion and relative phase differences had a minimal effect. In a second experiment using amplitude modulation, stimuli varied in deviation about a mean amplitude level and relative phase of modulation. Results showed smaller amplitude deviations promoted better fusion, but unlike frequency modulation, relative phase differences were also important. In a third experiment, frequency modulation, amplitude modulation and mixed modulation were arranged in all possible voicings. Results showed frequency modulation in the lower voice and less variance in amplitude envelopes contributed to an increase in fusion. The theory that similar modulations would promote better fusion was only marginally supported. For these experiments, results revealed differences depending on modulation type and that a lesser amount of modulation fosters greater fusion.

Predictors of proximal tibia anterior shear force during a vertical stop-jump.

PubMed

Sell, Timothy C; Ferris, Cheryl M; Abt, John P; Tsai, Yung-Shen; Myers, Joseph B; Fu, Freddie H; Lephart, Scott M

2007-12-01

Anterior cruciate ligament (ACL) continues to be a significant medical issue for athletes participating in sports and recreational activities. Biomechanical analyses have determined that anterior shear force is the most direct loading mechanism of the ACL and a probable component of noncontact ACL injury. The purpose of this study was to examine the biomechanical predictors of proximal tibia anterior shear force during a stop-jump task. A biomechanical and electromyographic (EMG) analysis of the knee was conducted while subjects performed a vertical stop-jump task. The task was chosen to simulate an athletic maneuver that included a landing with a sharp deceleration and a change in direction. The final regression model indicated that posterior ground reaction force, external knee flexion moment, knee flexion angle, integrated EMG activity of the vastus lateralis, and sex (female) would significantly predict proximal tibia anterior shear force (p < 0.0001, R2 = 0.8609). Knee flexion moment had the greatest influence on proximal tibia anterior shear force. The mathematical relationships elucidated in the current study support previous clinical and basic science research examining noncontact ACL injuries. This data provides important evidence for clinicians who are examining the risk factors for these injuries and developing/validating training programs to reduce the incidence of injury. Copyright 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

SHARP: Subsonic High Altitude Research Platform

NASA Technical Reports Server (NTRS)

Beals, Todd; Burton, Craig; Cabatan, Aileen; Hermano, Christine; Jones, Tom; Lee, Susan; Radloff, Brian

1991-01-01

The Universities Space Research Association is sponsoring an undergraduate program which is geared to designing an aircraft that can study the ozone layer at the equator. This aircraft must be able to satisfy four mission profiles. Mission one is a polar mission that ranges from Chile to the South Pole and back to Chile, a total range of 6000 n.mi. at 100,000 ft with a 2500 lb payload. The second mission is also a polar mission, with an altitude of 70,000 ft and an increased payload of 4000 lbs. For the third mission, the aircraft will takeoff at NASA Ames, cruise at 100,000 ft carrying a 2500 lb payload, and land at Puerto Montt, Chile. The final mission requires the aircraft to take off at NASA Ames, cruise at 100,000 ft with a 1000 lb payload, make an excursion to 120,000 ft, and land at Howard AFB, Panama. Three missions require that a subsonic Mach number be maintained due to constraints imposed by the air sampling equipment. The aircraft need not be manned for all four missions. Three aircraft configurations have been determined to be the most suitable for meeting the above requirements. In the event that a requirement cannot be obtained within the given constraints, recommendations for proposal modifications are given.

Soil respiration at the Amargosa Desert Research site: A section in U.S. Geological Survey Toxic Substances Hydrology Program: Proceedings of the technical meeting, Charleston, South Carolina, March 8-12, 1999: Volume 3 (Part C) (WRI 99-4018C)

USGS Publications Warehouse

Riggs, Alan C.; Striegl, Robert G.; Maestas, Florentino B.; Morganwalp, David W.; Buxton, Herbert T.

1999-01-01

Automated opaque flux-chamber measurements of soil carbon dioxide (CO2) flux (soil respiration) into the atmosphere at the Amargosa Desert Research Site show seasonal and diel cycles of soil respiration that are closely linked with soil temperature and soil moisture. During 1998, soil respiration increased with soil warming through spring, reaching a maximum rate (not counting anomalously high values scattered through the record) of about 0.055 moles CO2 m-2 day-1 around Julian Day 120. Respiration rates then declined along with volumetric soil moisture content, tending to stay at or below about 0.02 moles CO2 per square meter per day (m-2 day -1) for the rest of the year, except after summer rainfalls when respiration sharply increased for short periods. The diel respiration pattern during dry spells is marked by a sharp rise in CO2 flux coincident with steeply rising soil temperatures in the morning, then dropping back to low levels about the time of maximum soil temperature. The reason for this pattern in unclear.

Surface-enhanced Raman scattering on periodic metal nanotips with tunable sharpness.

PubMed

Linn, Nicholas C; Sun, Chih-Hung; Arya, Ajay; Jiang, Peng; Jiang, Bin

2009-06-03

This paper reports on a scalable bottom-up technology for producing periodic gold nanotips with tunable sharpness as surface-enhanced Raman scattering (SERS) substrates. Inverted silicon pyramidal pits, which are templated from non-close-packed colloidal crystals prepared by a spin-coating technology, are used as structural templates to replicate arrays of polymer nanopyramids with nanoscale sharp tips. The deposition of a thin layer of gold on the polymer nanopyramids leads to the formation of SERS-active substrates with a high enhancement factor (up to 10(8)). The thickness of the deposited metal determines the sharpness of the nanotips and the resulting Raman enhancement factor. Finite-element electromagnetic modeling shows that the nanotips can significantly enhance the local electromagnetic field and the sharpness of nanotips greatly affects the SERS enhancement.

Relationship of intentional self-harm using sharp objects with depressive and dissociative tendencies in pre-adolescence-adolescence.

PubMed

Sho, Noriko; Oiji, Arata; Konno, Chizue; Toyohara, Koji; Minami, Tatsuya; Arai, Takashi; Seike, Yoji

2009-06-01

The objectives of the present study were to (i) evaluate the prevalence of children and adolescents who have engaged in intentional self-harm using a sharp object; and (ii) investigate the relationship between self-harm with sharp objects and depressive tendencies or dissociative tendencies. A total of 1938 students in grades 5-12 in Yokohama, Japan, were enrolled, and they completed anonymous self-report questionnaires including a question about intentional self-harm with a sharp object, the Depression Self-Rating Scale for Children (DSRSC) and the Adolescent Dissociative Experiences Scale (A-DES). The prevalence of self-harm using sharp object was 5.4% among male 5th-6th graders, 4.0% among female 5th-6th graders, 5.3% among male 7th-9th graders, 15.1% among female 7th-9th graders, 6.6% among male 10th-12th graders, and 9.6% among female 10th-12th graders. Categorical regression analysis showed that a small amount of variance in self-harm by sharp object was explained by DSRSC and A-DES scores. Self-harm with a sharp object was prevalent among pre-adolescents and adolescents and was associated with depressive and dissociative tendencies.

The Helioseismic and Magnetic Imager (HMI) Vector Magnetic Field Pipeline: SHARPs - Space-Weather HMI Active Region Patches

NASA Astrophysics Data System (ADS)

Bobra, M. G.; Sun, X.; Hoeksema, J. T.; Turmon, M.; Liu, Y.; Hayashi, K.; Barnes, G.; Leka, K. D.

2014-09-01

A new data product from the Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics Observatory (SDO) called Space-weather HMI Active Region Patches ( SHARPs) is now available. SDO/HMI is the first space-based instrument to map the full-disk photospheric vector magnetic field with high cadence and continuity. The SHARP data series provide maps in patches that encompass automatically tracked magnetic concentrations for their entire lifetime; map quantities include the photospheric vector magnetic field and its uncertainty, along with Doppler velocity, continuum intensity, and line-of-sight magnetic field. Furthermore, keywords in the SHARP data series provide several parameters that concisely characterize the magnetic-field distribution and its deviation from a potential-field configuration. These indices may be useful for active-region event forecasting and for identifying regions of interest. The indices are calculated per patch and are available on a twelve-minute cadence. Quick-look data are available within approximately three hours of observation; definitive science products are produced approximately five weeks later. SHARP data are available at jsoc.stanford.edu and maps are available in either of two different coordinate systems. This article describes the SHARP data products and presents examples of SHARP data and parameters.

INFORMATIONAL STRESS AS A DEPRESSION INDUCING FACTOR (EXPERIMENTAL STUDY).

PubMed

Matitaishvili, T; Domianidze, T; Burdjanadze, G; Nadareishvili, D; Khananashvili, M

2017-01-01

Chronic psychogenic stress represents the major initiating agent of psychoneural diseases including depression. We used informational stress model for the purpose of modelling chronic psychogenic stress and depression. The aim of the research was to study behavior of dominant and submissive rats at different stages of informational stress and during depression state. In order to study anxiety and depressive behavior of rats we used "forced swim", "elevated cross maze" and "open-field" tests. The obtained results showed that chronic stressing procedure performed on rats by using the mentioned "informational" stress model led to the development of depression both in dominant and submissive rats. Stressing procedure caused sharp increase of serotonin concentration in hypothalamus of dominant and submissive rats. Under behavioral depression background, sharp increase of serotonin concentration in hypothalamus has been revealed which is caused by the peculiarities of stress model (by uncontrollable stressor. Specifically, by inevitable electric painful irritation).

Creating Resilient IT: How the Sign-Out Sheet Shows Clinicians Make Healthcare Work

PubMed Central

Nemeth, Christopher; Nunnally, Mark; O’Connor, Michael; Cook, Richard

2006-01-01

Information technology (IT) systems have been described as brittle and prone to automation surprises. Recent report of information system failure, particularly computerized physician order entry (CPOE) systems, shows the result of IT failure in actual practice. Such mismatches with healthcare work requirements necessitate improvement to IT research and development. Efforts to develop successful IT systems for healthcare’s sharp end must incorporate properties that reflect workers’ initiative in respose to domain constraints. Resilience is the feature of some systems that makes it possible for them to respond to sudden, unanticipated demands for performance and return to normal operation quickly, with minimum decrement in performance. Workers create resilience at healthcare’s sharp end by daily confronting constraints and obstacles that need to be surmounted in order to accomplish results. The sign-out sheet is an example of resilience that can be used to guide IT development. PMID:17238408

Vertical versus Lateral Two-Dimensional Heterostructures: On the Topic of Atomically Abrupt p/n-Junctions.

PubMed

Zhou, Ruiping; Ostwal, Vaibhav; Appenzeller, Joerg

2017-08-09

The key appeal of two-dimensional (2D) materials such as graphene, transition metal dichalcogenides (TMDs), or phosphorene for electronic applications certainly lies in their atomically thin nature that offers opportunities for devices beyond conventional transistors. It is also this property that makes them naturally suited for a type of integration that is not possible with any three-dimensional (3D) material, that is, forming heterostructures by stacking dissimilar 2D materials together. Recently, a number of research groups have reported on the formation of atomically sharp p/n-junctions in various 2D heterostructures that show strong diode-type rectification. In this article, we will show that truly vertical heterostructures do exhibit much smaller rectification ratios and that the reported results on atomically sharp p/n-junctions can be readily understood within the framework of the gate and drain voltage response of Schottky barriers that are involved in the lateral transport.

Shefex -a Low Cost Highly Efficient Flight Experiment

NASA Astrophysics Data System (ADS)

Longo, J. M. A.

2005-02-01

The SHarp Edge Flight EXperiment, SHEFEX is aimed to investigate the behavior and the possibilities of an improved shape for aerospace vehicles considering sharp edges and facetted surfaces. It is a basic in-flight experimentation research on hypersonic technologies for future launcher vehicles but not a re-entry experiment, being performed under responsibility of the German Aerospace Center (DLR). Here it is briefly described the overall philosophy of the project, schedule for flight on top of a sounding rocket in the first half of 2005. The approaches adopted on each of the involved disciplines, i.e. mission system and launcher; aerodynamics, aerothermodynamics and in-flight measurement techniques; structure and thermal protection systems, including the passenger experiments are also discussed. The paper is aimed to show that the approach here proposed is an economical way to acquire important knowledge in the physics of the hypersonic flow.

Investigation of a “Sharps” Incident

DOE PAGES

Cournoyer, Michael Edward; Trujillo, Stanley; Schreiber, Stephen Bruce

2016-08-03

Special nuclear material research, process development, technology demonstration, and manufacturing capabilities are provided at the Los Alamos National Laboratory Plutonium Facility. Engineered barriers provide the most effective protection from radioactive and hazardous materials. The Worker Safety Security Team augments these passive safety feature by investigating incidents to identify appropriate prevention and mitigation measures. “Learning Teams” facilitate employee feedback loop and integration toward process improvement. Here, this article reports an investigation of a “Sharps” incident and reviews a case study of a technician that cuts his left thumb while making a gasket. Causal analysis of the sharps incident uncovered contributing factorsmore » that created the environment in which the incident occurred. Finally, latent organizational conditions that created error-likely situations or weakened defenses were identified and controlled. Effective improvements that reduce the probability or consequence of similar sharps incidents were implemented.« less

FY16 Status Report on NEAMS Neutronics Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, C. H.; Shemon, E. R.; Smith, M. A.

2016-09-30

The goal of the NEAMS neutronics effort is to develop a neutronics toolkit for use on sodium-cooled fast reactors (SFRs) which can be extended to other reactor types. The neutronics toolkit includes the high-fidelity deterministic neutron transport code PROTEUS and many supporting tools such as a cross section generation code MC 2-3, a cross section library generation code, alternative cross section generation tools, mesh generation and conversion utilities, and an automated regression test tool. The FY16 effort for NEAMS neutronics focused on supporting the release of the SHARP toolkit and existing and new users, continuing to develop PROTEUS functions necessarymore » for performance improvement as well as the SHARP release, verifying PROTEUS against available existing benchmark problems, and developing new benchmark problems as needed. The FY16 research effort was focused on further updates of PROTEUS-SN and PROTEUS-MOCEX and cross section generation capabilities as needed.« less

A modified Holly-Preissmann scheme for simulating sharp concentration fronts in streams with steep velocity gradients using RIV1Q

NASA Astrophysics Data System (ADS)

Liu, Zhao-wei; Zhu, De-jun; Chen, Yong-can; Wang, Zhi-gang

2014-12-01

RIV1Q is the stand-alone water quality program of CE-QUAL-RIV1, a hydraulic and water quality model developed by U.S. Army Corps of Engineers Waterways Experiment Station. It utilizes an operator-splitting algorithm and the advection term in governing equation is treated using the explicit two-point, fourth-order accurate, Holly-Preissmann scheme, in order to preserve numerical accuracy for advection of sharp gradients in concentration. In the scheme, the spatial derivative of the transport equation, where the derivative of velocity is included, is introduced to update the first derivative of dependent variable. In the stream with larger cross-sectional variation, steep velocity gradient can be easily found and should be estimated correctly. In the original version of RIV1Q, however, the derivative of velocity is approximated by a finite difference which is first-order accurate. Its leading truncation error leads to the numerical error of concentration which is related with the velocity and concentration gradients and increases with the decreasing Courant number. The simulation may also be unstable when a sharp velocity drop occurs. In the present paper, the derivative of velocity is estimated with a modified second-order accurate scheme and the corresponding numerical error of concentration decreases. Additionally, the stability of the simulation is improved. The modified scheme is verified with a hypothetical channel case and the results demonstrate that satisfactory accuracy and stability can be achieved even when the Courant number is very low. Finally, the applicability of the modified scheme is discussed.

A New Classification Scheme for For-Profit Institutions. Fact Sheet

ERIC Educational Resources Information Center

Institute for Higher Education Policy, 2012

2012-01-01

For-profit institutions are more visible today among policymakers, researchers, and investors, due in large part to the sharp rise in the number of students attending them over the last decade. From 2000 to 2009, enrollment in the for-profit sector tripled while enrollment in the public and not-for-profit sectors increased by less than 25 percent.…

School Finance Reform and the Distribution of Student Achievement. NBER Working Paper No. 22011. Revised

ERIC Educational Resources Information Center

Lafortune, Julien; Rothstein, Jesse; Schanzenbach, Diane Whitmore

2016-01-01

We study the impact of post-1990 school finance reforms, during the so-called "adequacy" era, on absolute and relative spending and achievement in low-income school districts. Using an event study research design that exploits the apparent randomness of reform timing, we show that reforms lead to sharp, immediate, and sustained increases…

The Provision and Completion of Gender-Specific Services for Girls on Probation: Variation by Race and Ethnicity

ERIC Educational Resources Information Center

Wolf, Angela M.; Graziano, Juliette; Hartney, Christopher

2009-01-01

Beginning in the late 1980s, the number of girls entering the juvenile justice system increased dramatically. Although historically girls had entered the justice system with status offenses, recent examinations suggest a sharp rise in the number of girls charged with more serious crimes. Researchers and policy makers have increasingly acknowledged…

Corner smoothing of 2D milling toolpath using b-spline curve by optimizing the contour error and the feedrate

NASA Astrophysics Data System (ADS)

Özcan, Abdullah; Rivière-Lorphèvre, Edouard; Ducobu, François

2018-05-01

In part manufacturing, efficient process should minimize the cycle time needed to reach the prescribed quality on the part. In order to optimize it, the machining time needs to be as low as possible and the quality needs to meet some requirements. For a 2D milling toolpath defined by sharp corners, the programmed feedrate is different from the reachable feedrate due to kinematic limits of the motor drives. This phenomena leads to a loss of productivity. Smoothing the toolpath allows to reduce significantly the machining time but the dimensional accuracy should not be neglected. Therefore, a way to address the problem of optimizing a toolpath in part manufacturing is to take into account the manufacturing time and the part quality. On one hand, maximizing the feedrate will minimize the manufacturing time and, on the other hand, the maximum of the contour error needs to be set under a threshold to meet the quality requirements. This paper presents a method to optimize sharp corner smoothing using b-spline curves by adjusting the control points defining the curve. The objective function used in the optimization process is based on the contour error and the difference between the programmed feedrate and an estimation of the reachable feedrate. The estimation of the reachable feedrate is based on geometrical information. Some simulation results are presented in the paper and the machining times are compared in each cases.

Postabortion Care: 20 Years of Strong Evidence on Emergency Treatment, Family Planning, and Other Programming Components

PubMed Central

Huber, Douglas; Curtis, Carolyn; Irani, Laili; Pappa, Sara; Arrington, Lauren

2016-01-01

ABSTRACT Worldwide 75 million women need postabortion care (PAC) services each year following safe or unsafe induced abortions and miscarriages. We reviewed more than 550 studies on PAC published between 1994 and 2013 in the peer-reviewed and gray literature, covering emergency treatment, postabortion family planning, organization of services, and related topics that impact practices and health outcomes, particularly in the Global South. In this article, we present findings from studies with strong evidence that have major implications for programs and practice. For example, vacuum aspiration reduced morbidity, costs, and time in comparison to sharp curettage. Misoprostol 400 mcg sublingually or 600 mcg orally achieved 89% to 99% complete evacuation rates within 2 weeks in multiple studies and was comparable in effectiveness, safety, and acceptability to manual vacuum aspiration. Misoprostol was safely introduced in several PAC programs through mid-level providers, extending services to secondary hospitals and primary health centers. In multiple studies, postabortion family planning uptake before discharge increased by 30–70 percentage points within 1–3 years of strengthening postabortion family planning services; in some cases, increases up to 60 percentage points in 4 months were achieved. Immediate postabortion contraceptive acceptance increased on average from 32% before the interventions to 69% post-intervention. Several studies found that women receiving immediate postabortion intrauterine devices and implants had fewer unintended pregnancies and repeat abortions than those who were offered delayed insertions. Postabortion family planning is endorsed by the professional organizations of obstetricians/gynecologists, midwives, and nurses as a standard of practice; major donors agree, and governments should be encouraged to provide universal access to postabortion family planning. Important program recommendations include offering all postabortion women family planning counseling and services before leaving the facility, especially because fertility returns rapidly (within 2 to 3 weeks); postabortion family planning services can be quickly replicated to multiple sites with high acceptance rates. Voluntary family planning uptake by method should always be monitored to document program and provider performance. In addition, vacuum aspiration and misoprostol should replace sharp curettage to treat incomplete abortion for women who meet eligibility criteria. PMID:27571343

A comparison of coupled freshwater-saltwater sharp-interface and convective-dispersive models of saltwater intrusion in a layered aquifer system

USGS Publications Warehouse

Hill, Mary C.

1988-01-01

Simulated results of the coupled freshwater-saltwater sharp interface and convective-dispersive numerical models are compared by using steady-state cross-sectional simulations. The results indicate that in some aquifers the calculated sharp interface is located further landward than would be expected.

Notes on distribution and ecology of Philonthus spinipes Sharp (Coleoptera: Staphylinidae) in the Polish Carpathians.

PubMed

Mazur, Andrzej; Guo, Wanyue; Górz, Andrzej

2017-11-30

Philonthus spinipes Sharp for the first time was described from East Asia (Sharp 1874). Presently the species occurs in the whole Palaearctic region. Original distribution of this species is difficult to define because it has obviously extended its distribution range westwards (Schillhammer 1999).

Development of the Adult Scale of Hostility and Aggression: Reactive-Proactive (A-SHARP)

ERIC Educational Resources Information Center

Matlock, Scott Thomas; Aman, Michael G.

2011-01-01

In this study, the authors developed the Adult Scale of Hostility and Aggression Reactive-Proactive (A-SHARP). Sixty-one caregivers rated 512 individuals with intellectual and developmental disabilities on the A-SHARP. Exploratory factor analysis revealed 5 factors on the Problem Scale: (a) Verbal Aggression, (b) Physical Aggression, (c) Hostile…

The Russian Way of War: Post Soviet Adaptations in the Russian Military

DTIC Science & Technology

2013-12-13

226Thomas Goltz , Georgia Diary (London: M. E. Sharpe, 2006), 253. 227Pavel Felgenhauer, “After August 7: The Escalation of the Russian-Georgian War,” in The...Sharpe, 2009. Goltz , Thomas. Georgia Diary. London: M. E. Sharpe, 2006. Goytisolo, Juan. Landscapes of War: From Sarajevo to Chechnya. Translated

Numerical analysis of mixing by sharp-edge-based acoustofluidic micromixer

NASA Astrophysics Data System (ADS)

Nama, Nitesh; Huang, Po-Hsun; Jun Huang, Tony; Costanzo, Francesco

2015-11-01

Recently, acoustically oscillated sharp-edges have been employed to realize rapid and homogeneous mixing at microscales (Huang, Lab on a Chip, 13, 2013). Here, we present a numerical model, qualitatively validated by experimental results, to analyze the acoustic mixing inside a sharp-edge-based micromixer. We extend our previous numerical model (Nama, Lab on a Chip, 14, 2014) to combine the Generalized Lagrangian Mean (GLM) theory with the convection-diffusion equation, while also allowing for the presence of a background flow as observed in a typical sharp-edge-based micromixer. We employ a perturbation approach to divide the flow variables into zeroth-, first- and second-order fields which are successively solved to obtain the Lagrangian mean velocity. The Langrangian mean velocity and the background flow velocity are further employed with the convection-diffusion equation to obtain the concentration profile. We characterize the effects of various operational and geometrical parameters to suggest potential design changes for improving the mixing performance of the sharp-edge-based micromixer. Lastly, we investigate the possibility of generation of a spatio-temporally controllable concentration gradient by placing sharp-edge structures inside the microchannel.

SHARP: A multi-mission artificial intelligence system for spacecraft telemetry monitoring and diagnosis

NASA Technical Reports Server (NTRS)

Lawson, Denise L.; James, Mark L.

1989-01-01

The Spacecraft Health Automated Reasoning Prototype (SHARP) is a system designed to demonstrate automated health and status analysis for multi-mission spacecraft and ground data systems operations. Telecommunications link analysis of the Voyager 2 spacecraft is the initial focus for the SHARP system demonstration which will occur during Voyager's encounter with the planet Neptune in August, 1989, in parallel with real time Voyager operations. The SHARP system combines conventional computer science methodologies with artificial intelligence techniques to produce an effective method for detecting and analyzing potential spacecraft and ground systems problems. The system performs real time analysis of spacecraft and other related telemetry, and is also capable of examining data in historical context. A brief introduction is given to the spacecraft and ground systems monitoring process at the Jet Propulsion Laboratory. The current method of operation for monitoring the Voyager Telecommunications subsystem is described, and the difficulties associated with the existing technology are highlighted. The approach taken in the SHARP system to overcome the current limitations is also described, as well as both the conventional and artificial intelligence solutions developed in SHARP.

A Note on Trader Sharpe Ratios

PubMed Central

Coates, John M.; Page, Lionel

2009-01-01

Traders in the financial world are assessed by the amount of money they make and, increasingly, by the amount of money they make per unit of risk taken, a measure known as the Sharpe Ratio. Little is known about the average Sharpe Ratio among traders, but the Efficient Market Hypothesis suggests that traders, like asset managers, should not outperform the broad market. Here we report the findings of a study conducted in the City of London which shows that a population of experienced traders attain Sharpe Ratios significantly higher than the broad market. To explain this anomaly we examine a surrogate marker of prenatal androgen exposure, the second-to-fourth finger length ratio (2D∶4D), which has previously been identified as predicting a trader's long term profitability. We find that it predicts the amount of risk taken by traders but not their Sharpe Ratios. We do, however, find that the traders' Sharpe Ratios increase markedly with the number of years they have traded, a result suggesting that learning plays a role in increasing the returns of traders. Our findings present anomalous data for the Efficient Markets Hypothesis. PMID:19946367

SHARPs - A Near-Real-Time Space Weather Data Product from HMI

NASA Astrophysics Data System (ADS)

Bobra, M.; Turmon, M.; Baldner, C.; Sun, X.; Hoeksema, J. T.

2012-12-01

A data product from the Helioseismic and Magnetic Imager (HMI) on the Solar Dynamics Observatory (SDO), called Space-weather HMI Active Region Patches (SHARPs), is now available through the SDO Joint Science Operations Center (JSOC) and the Virtual Solar Observatory. SHARPs are magnetically active regions identified on the solar disk and tracked automatically in time. SHARP data are processed within a few hours of the observation time. The SHARP data series contains active region-sized disambiguated vector magnetic field data in both Lambert Cylindrical Equal-Area and CCD coordinates on a 12 minute cadence. The series also provides simultaneous HMI maps of the line-of-sight magnetic field, continuum intensity, and velocity on the same ~0.5 arc-second pixel grid. In addition, the SHARP data series provides space weather quantities computed on the inverted, disambiguated, and remapped data. The values for each tracked region are computed and updated in near real time. We present space weather results for several X-class flares; furthermore, we compare said space weather quantities with helioseismic quantities calculated using ring-diagram analysis.

A note on trader Sharpe Ratios.

PubMed

Coates, John M; Page, Lionel

2009-11-25

Traders in the financial world are assessed by the amount of money they make and, increasingly, by the amount of money they make per unit of risk taken, a measure known as the Sharpe Ratio. Little is known about the average Sharpe Ratio among traders, but the Efficient Market Hypothesis suggests that traders, like asset managers, should not outperform the broad market. Here we report the findings of a study conducted in the City of London which shows that a population of experienced traders attain Sharpe Ratios significantly higher than the broad market. To explain this anomaly we examine a surrogate marker of prenatal androgen exposure, the second-to-fourth finger length ratio (2D:4D), which has previously been identified as predicting a trader's long term profitability. We find that it predicts the amount of risk taken by traders but not their Sharpe Ratios. We do, however, find that the traders' Sharpe Ratios increase markedly with the number of years they have traded, a result suggesting that learning plays a role in increasing the returns of traders. Our findings present anomalous data for the Efficient Markets Hypothesis.

SHARP: A multi-mission AI system for spacecraft telemetry monitoring and diagnosis

NASA Technical Reports Server (NTRS)

Lawson, Denise L.; James, Mark L.

1989-01-01

The Spacecraft Health Automated Reasoning Prototype (SHARP) is a system designed to demonstrate automated health and status analysis for multi-mission spacecraft and ground data systems operations. Telecommunications link analysis of the Voyager II spacecraft is the initial focus for the SHARP system demonstration which will occur during Voyager's encounter with the planet Neptune in August, 1989, in parallel with real-time Voyager operations. The SHARP system combines conventional computer science methodologies with artificial intelligence techniques to produce an effective method for detecting and analyzing potential spacecraft and ground systems problems. The system performs real-time analysis of spacecraft and other related telemetry, and is also capable of examining data in historical context. A brief introduction is given to the spacecraft and ground systems monitoring process at the Jet Propulsion Laboratory. The current method of operation for monitoring the Voyager Telecommunications subsystem is described, and the difficulties associated with the existing technology are highlighted. The approach taken in the SHARP system to overcome the current limitations is also described, as well as both the conventional and artificial intelligence solutions developed in SHARP.

Nanoscale thermal imaging of VO2 via Poole-Frenkel conduction

NASA Astrophysics Data System (ADS)

Spitzig, Alyson; Hoffman, Jason D.; Pivonka, Adam E.; Mickalide, Harry; Frenzel, Alex; Kim, Jeehoon; Ko, Changhyun; Zhou, You; O'Connor, Kevin; Hudson, Eric W.; Ramanathan, Shriram; Hoffman, Jennifer E.

We present a novel method for nanoscale thermal imaging of insulating thin films. We demonstrate this method on VO2, which undergoes a sharp insulator-to-metal transition at 340 K. We sweep the voltage applied to a conducting atomic force microscope tip in contact mode at room temperature and measure the resultant current through a VO2 film. The Poole-Frenkel (PF) conduction mechanism, which dominates in the insulating state of VO2, is fit to extract the local temperature of the film using fundamental constants and known film properties. We measure the local electric field and temperature immediately preceding the insulator-to-metal transition in VO2 to determine whether the transition can be triggered by an applied electric field alone. We calculate an average temperature of 334 +/- 5 K, implying that Joule heating has locally warmed the sample very close to the transition temperature. Our thermometry technique opens up the possibility to measure the local temperature of any film dominated by the PF conduction mechanism, and presents the opportunity to extend our technique to other conduction mechanisms. Canada Excellence Research Chair program and NSERC - CGSM.

Panelists Remarks -- The Start of the Forum on Physics and Society

NASA Astrophysics Data System (ADS)

Schwartz, Brian

2012-03-01

The early days of the Forum on Physics and Society, its leadership and programs will be reviewed. Science was late in joining the major changes taking place in American society in the late 1960s. At the time, APS and other professional science societies were limited to research, education and history. The concept that the APS would, at its meetings, deal with physics and society matters was not seen as part of the Society's mission. At the time there was turmoil in American society concerning the Vietnam War, civil rights, free speech issues and the military-industrial complex. Also exacerbating the situation was the sharp downturn of employment opportunities for the large numbers of Ph.D. scientist produced by the post sputnik encouragement and funding of science education. I and Emanuel Maxwell of MIT collected the 1 percent (approximately 200) signatures of the then APS membership required to establish a new unit to be named, The Division of Physics and Society. This resulted in much debate within the Society and ultimately resolved with the establishment of new class of APS units designated as Forums.

MO-FG-204-09: High Spatial Resolution and Artifact-Free CT Bone Imaging at Off-Centered Positions: An Application of Model-Based Iterative Reconstruction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, G; Li, K; Gomez-Cardona, D

Purpose: Although the anatomy of interest should be positioned as close as possible to the isocenter of CT scanners, off-centering may be inevitable during certain exams in clinical practice such as lumbar spine and elbow imaging. Off-centering degrades image sharpness, generates streak artifacts, and sometimes creates blooming artifacts due to truncation. The purpose of this work was to investigate whether the use of model-based image reconstruction (MBIR) can alleviate the negative impacts of off-centering to achieve high quality CT bone imaging. Methods: Both an anthropomorphic phantom and an ex vivo swine elbow sample were scanned at centered and off-centered positionsmore » using clinical CT bone scan protocols. The magnitude of off-centering was determined from localizer radiographs. Both FBP and MBIR reconstructions were performed. For FBP, both standard and Bone Plus kernels commonly used in bone imaging were used. Objective assessment of image sharpness, noise standard deviation, and noise nonuniformity were performed. Additionally, we retrospectively analyzed human subject data acquired under off-centered conditions as a validation study. Results: In FBP images of the phantom, off-centering by 10 cm led to a 14% increase in noise (p<1e-3) and a 68% increase in noise nonuniformity (p<0.02). A visible drop in bone sharpness was observed. In contrast, no significant difference in the noise magnitude or the noise nonuniformity between the centered and off-centered MBIR images was found. The image sharpness of off-centered MBIR images outperformed that of FBP images reconstructed with the Bone Plus kernel. In images of the swine elbow off-centered by 20 cm, not only was the noise and spatial resolution performance improved by MBIR, truncation artifacts were also elliminated. The human subject study generated similar results, in which the visibility of the off-centered lumbar spine was significantly improved. Conclusion: High quality CT bone imaging at off-centered positions can be achieved using MBIR. This work was partially supported by an NIH grant R01CA169331 and GE Healthcare. K. Li, D. Gomez-Cardona: Nothing to disclose. G.-H. Chen: Research funded, GE Healthcare; Research funded, Siemens AX. A. Budde, J. Hsieh: Employee, GE Healthcare.« less

Comparative study of helimagnets MnSi and Cu2OSeO3 at high pressures

NASA Astrophysics Data System (ADS)

Stishov, Sergei; Sidorov, Vladimir; Petrova, Alla; Berdonosov, Peter; Dolgikh, Valery

2014-03-01

The heat capacity of helical magnets Cu2OSeO3 and MnSi has been investigated at high pressures by the ac-calorimetric technique. Despite the differing nature of their magnetic moments, Cu2OSeO3 and MnSi demonstrate a surprising similarity in behavior of their magnetic and thermodynamic properties at the phase transition. Two characteristic features of the heat capacity at the phase transitions of both substances (peak and shoulder) behave also in a similar way at high pressures if analyzed as a function of temperature. This probably implies that the longitudinal spin fluctuations typical of weak itinerant magnets like MnSi contribute little to the phase transition. The shoulders of the heat capacity curves shrink with decreasing temperature suggesting that they arise from classical fluctuations. In case of MnSi the sharp peak and shoulder at the heat capacity disappear simultaneously probably signifying the existence of a tricritical point and confirming the fluctuation nature of the first order phase transition in MnSi as well as in Cu2OSeO3. This work was supported by the Russian Foundation for Basic Research (grant 12-02-00376-a, 12-03-92604), Program of the Physics Department of RAS on Strongly Correlated Electron Systems and Program of the Presidium of RAS on Strongly Compressed Matter.

Microgravity

NASA Image and Video Library

2001-06-06

X-rays diffracted from a well-ordered protein crystal create sharp patterns of scattered light on film. A computer can use these patterns to generate a model of a protein molecule. To analyze the selected crystal, an X-ray crystallographer shines X-rays through the crystal. Unlike a single dental X-ray, which produces a shadow image of a tooth, these X-rays have to be taken many times from different angles to produce a pattern from the scattered light, a map of the intensity of the X-rays after they diffract through the crystal. The X-rays bounce off the electron clouds that form the outer structure of each atom. A flawed crystal will yield a blurry pattern; a well-ordered protein crystal yields a series of sharp diffraction patterns. From these patterns, researchers build an electron density map. With powerful computers and a lot of calculations, scientists can use the electron density patterns to determine the structure of the protein and make a computer-generated model of the structure. The models let researchers improve their understanding of how the protein functions. They also allow scientists to look for receptor sites and active areas that control a protein's function and role in the progress of diseases. From there, pharmaceutical researchers can design molecules that fit the active site, much like a key and lock, so that the protein is locked without affecting the rest of the body. This is called structure-based drug design.

Safety climate and mindful safety practices in the oil and gas industry.

PubMed

Dahl, Øyvind; Kongsvik, Trond

2018-02-01

The existence of a positive association between safety climate and the safety behavior of sharp-end workers in high-risk organizations is supported by a considerable body of research. Previous research has primarily analyzed two components of safety behavior, namely safety compliance and safety participation. The present study extends previous research by looking into the relationship between safety climate and another component of safety behavior, namely mindful safety practices. Mindful safety practices are defined as the ability to be aware of critical factors in the environment and to act appropriately when dangers arise. Regression analysis was used to examine whether mindful safety practices are, like compliance and participation, promoted by a positive safety climate, in a questionnaire-based study of 5712 sharp-end workers in the oil and gas industry. The analysis revealed that a positive safety climate promotes mindful safety practices. The regression model accounted for roughly 31% of the variance in mindful safety practices. The most important safety climate factor was safety leadership. The findings clearly demonstrate that mindful safety practices are highly context-dependent, hence, manageable and susceptible to change. In order to improve safety climate in a direction which is favorable for mindful safety practices, the results demonstrate that it is important to give the fundamental features of safety climate high priority and in particular that of safety leadership. Copyright © 2017 National Safety Council and Elsevier Ltd. All rights reserved.

How sharp is sharp? Towards quantification of the sharpness and penetration ability of kitchen knives used in stabbings.

PubMed

Hainsworth, S V; Delaney, R J; Rutty, G N

2008-07-01

Stabbing is the most common method for violent death in the UK. As part of their investigation, forensic pathologists are commonly asked to estimate or quantify the degree of force required to create a wound. The force required to penetrate the skin and body by a knife is a complex function of the sharpness of the knife, the area of the body and alignment with cleavage lines of the skin, the angle of attack and the relative movement of the person stabbing relative to the victim being stabbed. This makes it difficult for the forensic pathologist to give an objective answer to the question; hence, subjective estimations are often used. One area where some degree of quantification is more tractable is in assessing how sharp an implement (particularly a knife) is. This paper presents results of a systematic study of how the different aspects of knife geometry influence sharpness and presents a simple test for assessing knife sharpness using drop testing. The results show that the radius of the blunt edge at the tip is important for controlling the penetration ability of a kitchen knife. Using high-speed video, it also gives insight into the mechanism of knife penetration into the skin. The results of the study will aid pathologists in giving a more informed answer to the question of the degree of force used in stabbing.

Keeping up with the Red Queen: the pace of aging as an adaptation.

PubMed

Lenart, Peter; Bienertová-Vašků, Julie

2017-08-01

For decades, a vast majority of biogerontologists assumed that aging is not and cannot be an adaptation. In recent years, however, several authors opposed this predominant view and repeatedly suggested that not only is aging an adaptation but that it is the result of a specific aging program. This issue almost instantaneously became somewhat controversial and many important authors produced substantial works refuting the notion of the aging program. In this article we review the current state of the debate and list the most important arguments proposed by both sides. Furthermore, although classical interpretations of the evolution of aging are in sharp contrast with the idea of programmed aging, we suggest that the truth might in fact very well lie somewhere in between. We also propose our own interpretation which states that although aging is in essence inevitable and results from damage accumulation rather than from a specific program, the actual rate of aging in nature may still be adaptive to some extent.

The Relevance of Culturally Based Curriculum and Instruction: The Case of Nancy Sharp

ERIC Educational Resources Information Center

Lipka, Jerry; Sharp, Nancy; Brenner, Betsy; Yanez, Evelyn; Sharp, Ferdinand

2005-01-01

Ms. Sharp's case is particularly instructive as it shows how this experienced Yup'ik teacher steeped in the traditions of her culture effectively implemented a culturally based math module. Ms. Sharp's pedagogical creatively allowed her to authentically bring together a core academic content area, math, with Yup'ik traditions, knowledge, and ways…

78 FR 59425 - Proposed Collection: Comment Request

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2013-09-26

... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... Service, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov... INFORMATION CONTACT: Requests for additional information or copies should be directed to Bruce A. Sharp...

77 FR 13176 - Proposed Collection: Comment Request

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... 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the Bureau of the Public Debt within the Department of the.... Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity...: Requests for additional information or copies should be directed to Bruce A. Sharp, Bureau of the Public...

77 FR 31689 - Proposed Information Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

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... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the.... Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity...: Requests for additional information or copies should be directed to Bruce A. Sharp, Bureau of the Public...

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... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently the.... Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The opportunity...: Requests for additional information or copies should be directed to Bruce A. Sharp, Bureau of the Public...

78 FR 21706 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

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... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas... INFORMATION CONTACT: Requests for additional information or copies should be directed to Bruce A. Sharp...

77 FR 60026 - Proposed Collection: Comment Request

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... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas... INFORMATION CONTACT: Requests for additional information or copies should be directed to Bruce A. Sharp...

77 FR 19424 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

..., as required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A..., Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.treas.gov . The...: Requests for additional information or copies should be directed to Bruce A. Sharp, Bureau of the Public...

77 FR 32180 - Proposed Collection: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-31

... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd... INFORMATION CONTACT: Requests for additional information or copies should be directed to Bruce A. Sharp...

The Formation and Erosion History of Mt. Sharp

NASA Technical Reports Server (NTRS)

Allen, Carlton C.; Dapremont, Angela M.

2014-01-01

The Curiosity rover is exploring 155 km diameter Gale crater and Mt. Sharp, Gale's 5 km high central mound (Fig. 1). This study addresses the formation and erosion history of Mt. Sharp. Gale lies on the topographic dichotomy between the southern highlands and the northern plains - a drop of over 2 km [1,2]. Altitude differences between the north and south rim reflect this regional slope, as do altitude differences between the deep annulus north of Mt. Sharp and the southern crater floor. Orbiter and rover images demonstrate that most exposed areas on Mt. Sharp consist of thin, sub-parallel units interpreted as sedimentary layers [3]. Gale is typical of the 50 large martian craters that have been totally or partially filled with such layers [4,5]. In many craters these sediments have been deeply eroded. Central Peak and Peak Ring: The highest point on Mt. Sharp, near the crater's center, is interpreted as a central peak [6]. The peak has a massive lower portion and a thin, smooth capping deposit (Fig. 2). Gale's size is transitional between martian craters with single central peaks and craters with peak rings approximately half the crater's diameter [2,6]. The boundaries of Mt. Sharp, as well as an arc of hills to the southeast of the mountain, closely match a circle approximately 80 km in diameter (Fig. 3). This morphology suggests that the Gale impact may have formed both a central peak and a partial peak ring, which is covered by the sediments of Mt. Sharp in the north and possibly exposed in the arc of eroded hills in the southeast quadrant (Figs. 3,4).

A comprehensive numerical analysis of background phase correction with V-SHARP.

PubMed

Özbay, Pinar Senay; Deistung, Andreas; Feng, Xiang; Nanz, Daniel; Reichenbach, Jürgen Rainer; Schweser, Ferdinand

2017-04-01

Sophisticated harmonic artifact reduction for phase data (SHARP) is a method to remove background field contributions in MRI phase images, which is an essential processing step for quantitative susceptibility mapping (QSM). To perform SHARP, a spherical kernel radius and a regularization parameter need to be defined. In this study, we carried out an extensive analysis of the effect of these two parameters on the corrected phase images and on the reconstructed susceptibility maps. As a result of the dependence of the parameters on acquisition and processing characteristics, we propose a new SHARP scheme with generalized parameters. The new SHARP scheme uses a high-pass filtering approach to define the regularization parameter. We employed the variable-kernel SHARP (V-SHARP) approach, using different maximum radii (R m ) between 1 and 15 mm and varying regularization parameters (f) in a numerical brain model. The local root-mean-square error (RMSE) between the ground-truth, background-corrected field map and the results from SHARP decreased towards the center of the brain. RMSE of susceptibility maps calculated with a spatial domain algorithm was smallest for R m between 6 and 10 mm and f between 0 and 0.01 mm -1 , and for maps calculated with a Fourier domain algorithm for R m between 10 and 15 mm and f between 0 and 0.0091 mm -1 . We demonstrated and confirmed the new parameter scheme in vivo. The novel regularization scheme allows the use of the same regularization parameter irrespective of other imaging parameters, such as image resolution. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Sustainable Hydro Assessment and Groundwater Recharge Projects (SHARP) in Germany - Water Balance Models

NASA Astrophysics Data System (ADS)

Niemand, C.; Kuhn, K.; Schwarze, R.

2010-12-01

SHARP is a European INTERREG IVc Program. It focuses on the exchange of innovative technologies to protect groundwater resources for future generations by considering the climate change and the different geological and geographical conditions. Regions involved are Austria, United Kingdom, Poland, Italy, Macedonia, Malta, Greece and Germany. They will exchange practical know-how and also determine know-how demands concerning SHARP’s key contents: general groundwater management tools, artificial groundwater recharge technologies, groundwater monitoring systems, strategic use of groundwater resources for drinking water, irrigation and industry, techniques to save water quality and quantity, drinking water safety plans, risk management tools and water balance models. SHARP Outputs & results will influence the regional policy in the frame of sustainable groundwater management to save and improve the quality and quantity of groundwater reservoirs for future generations. The main focus of the Saxon State Office for Environment, Agriculture and Landscape in this project is the enhancement and purposive use of water balance models. Already since 1992 scientists compare different existing water balance models on different scales and coupled with groundwater models. For example in the KLIWEP (Assessment of Impacts of Climate Change Projections on Water and Matter Balance for the Catchment of River Parthe in Saxony) project the coupled model WaSiM-ETH - PCGEOFIM® has been used to study the impact of climate change on water balance and water supplies. The project KliWES (Assessment of the Impacts of Climate Change Projections on Water and Matter Balance for Catchment Areas in Saxony) still running, comprises studies of fundamental effects of climate change on catchments in Saxony. Project objective is to assess Saxon catchments according to the vulnerability of their water resources towards climate change projections in order to derive region-specific recommendations for management actions. The model comparisons within reference areas showed significant differences in outcome. The values of water balance components calculated with different models partially fluctuate by a multiple of their value. The SHARP project was prepared in several previous projects that were testing suitable water balance models and is now able to assist the knowledge transfer.

An experimental study of the sources of fluctuating pressure loads beneath swept shock/boundary-layer interactions

NASA Technical Reports Server (NTRS)

Settles, G. S.; Garg, S.

1993-01-01

An experimental research program providing basic knowledge and establishing a database on the fluctuating pressure loads produced on aerodynamic surfaces beneath three dimensional shock wave/boundary layer interactions is described. Such loads constitute a fundamental problem of critical concern to future supersonic and hypersonic flight vehicles. A turbulent boundary layer on a flat plate is subjected to interactions with swept planar shock waves generated by sharp fins at angle of attack. Fin angles from 10 to 20 deg at freestream Mach numbers of 3 and 4 produce a variety of interaction strengths from weak to very strong. Miniature Kulite pressure transducers flush-mounted in the flat plate are used to measure interaction-induced wall pressure fluctuations. The distributions of properties of the pressure fluctuations, such as their ring levels, amplitude distributions, and power spectra, are also determined. Measurements were made for the first time in the aft regions of these interactions, revealing fluctuating pressure levels as high as 160 dB. These fluctuations are dominated by low frequency (0-5 kHz) signals. The maximum ring levels in the interactions show an increasing trend with increasing interaction strength. On the other hand, the maximum ring levels in the forward portion of the interactions decrease linearly with increasing interaction sweep back. These ring pressure distributions and spectra are correlated with the features of the interaction flowfield. The unsteadiness of the off-surface flowfield is studied using a new, non-intrusive technique based on the shadow graph method. The results indicate that the entire lambda-shock structure generated by the interaction undergoes relatively low-frequency oscillations. Some regions where particularly strong fluctuations are generated were identified. Fluctuating pressure measurements are also made along the line of symmetry of an axisymmetric jet impinging upon a flat plate at an angle. This flow was chosen as a simple analog to the impinging jet region found in the rear portion of the shock wave/boundary layer interactions under study. It is found that a sharp peak in ring pressure level exists at or near the mean stagnation point. It is suggested that the phenomena responsible for this peak may be active in the swept interactions as well, and may cause the extremely high fluctuating pressures observed in the impinging jet region in the present experimental program.

Development of renewable energy in China: Studying the experience and making recommendations for Russia

NASA Astrophysics Data System (ADS)

Lanshina, T. A.; Kulakov, A. V.

2017-07-01

The article reviews a state policy of China, due to which the country has managed to develop the world's largest sector of renewable energy sources (RES). Basic aspects of the formation and development of a comprehensive system of state support for the sector, i.e., the creation of scientific and technological advancement, stimulation of renewable energy equipment manufacturing, and support for RES electricity generation, are studied. Key programs implemented in specific stages are analyzed. Considerable attention is paid to the role and characteristics of foreign technology transfers. The dynamics of China's RES sector and the results of its rapid growth with the active participation of the state are researched. On the basis of the analysis, it is concluded that, in general, China's experience in development of RES is successful. Using the example of China, it is safe to say that, in the presence of a balanced state policy, a country is able to create in a decade a strong renewable energy equipment industry and to become a leader in the area of RES electricity generation. Specific features and main problems of the Russian RES sector are considered. On the basis of China's experience, recommendations for improving the state policy in RES are made for Russia. According to the authors, first of all, a sharp increase in state support for scientific research and development (R&D), pilot and demonstration projects, recognition of RES as a part of the fuel and energy sector at all tiers of authority, guarantees of state support for RES in the long run, ensuring access to long-term funds, and the creation of state programs supporting households participation in the distributed power generation are needed.

FY04 Engineering Technology Reports Technology Base

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharpe, R M

2005-01-27

Lawrence Livermore National Laboratory's Engineering Directorate has two primary discretionary avenues for its investment in technologies: the Laboratory Directed Research and Development (LDRD) program and the ''Tech Base'' program. This volume summarizes progress on the projects funded for technology-base efforts in FY2004. The Engineering Technical Reports exemplify Engineering's more than 50-year history of researching and developing (LDRD), and reducing to practice (technology-base) the engineering technologies needed to support the Laboratory's missions. Engineering has been a partner in every major program and project at the Laboratory throughout its existence, and has prepared for this role with a skilled workforce and technicalmore » resources. This accomplishment is well summarized by Engineering's mission: ''Enable program success today and ensure the Laboratory's vitality tomorrow''. LDRD is the vehicle for creating those technologies and competencies that are cutting edge. These require a significant level of research or contain some unknown that needs to be fully understood. Tech Base is used to apply those technologies, or adapt them to a Laboratory need. The term commonly used for Tech Base projects is ''reduction to practice''. Tech Base projects effect the natural transition to reduction-to-practice of scientific or engineering methods that are well understood and established. They represent discipline-oriented, core competency activities that are multi-programmatic in application, nature, and scope. The objectives of technology-base funding include: (1) the development and enhancement of tools and processes to provide Engineering support capability, such as code maintenance and improved fabrication methods; (2) support of Engineering science and technology infrastructure, such as the installation or integration of a new capability; (3) support for technical and administrative leadership through our technology Centers; and (4) the initial scoping and exploration of selected technology areas with high strategic potential, such as assessment of university, laboratory, and industrial partnerships. Engineering's five Centers, in partnership with the Division Leaders and Department Heads, focus and guide longer-term investments within Engineering. The Centers attract and retain top staff, develop and maintain critical core technologies, and enable programs. Through their technology-base projects, they oversee the application of known engineering approaches and techniques to scientific and technical problems. The Centers and their Directors are as follows: (1) Center for Computational Engineering: Robert M. Sharpe; (2) Center for Microtechnology and Nanotechnology: Raymond P. Mariella, Jr. (3) Center for Nondestructive Characterization: Harry E. Martz, Jr.; (4) Center for Precision Engineering: Keith Carlisle; and (5) Center for Complex Distributed Systems: Gregory J. Suski, Acting Director.« less

Distinctive distribution of defects in CdZnTe:In ingots and their effects on the photoelectric properties

NASA Astrophysics Data System (ADS)

Fu, Xu; Wang, Fang-Bao; Zuo, Xi-Ran; Wang, Ze-Jian; Wang, Qian-Ru; Wang, Ke-Qin; Xu, Ling-Yan; Xu, Ya-Dong; Guo, Rong-Rong; Yu, Hui; Jie, Wan-Qi

2018-03-01

Photoelectric properties of CdZnTe:In samples with distinctive defect distributions are investigated using various techniques. Samples cut from the head (T04) and tail (W02) regions of a crystal ingot show distinct differences in Te inclusion distribution. Obvious difference is not observed in Fourier transform infrared (FTIR) spectra, UV–Vis–NIR transmittance spectra, and I–V measurements. However, carrier mobility of the tip sample is higher than that of the tail according to the laser beam induced current (LBIC) measurements. Low temperature photoluminescence (PL) measurement presents sharp emission peaks of D0X and A0X, and relatively large peak of D0X (or A0X) / Dcomplex for T04, indicating a better crystalline quality. Thermally stimulated current (TSC) spectrum shows higher density of shallow point defects, i.e., Cd vacancies, {In}}{{Cd}}+, etc., in W02 sample, which could be responsible for the deterioration of electron mobility. Project supported by the National Natural Science Foundations of China (Grant Nos. 51502244, 51702271, U1631116, and 51372205), the National Key Research and Development Program of China (Grant Nos. 2016YFF0101301 and 2016YFE0115200), the Fund of the State Key Laboratory of Solidification Processing in Northwestern Polytechnical University, China (Grant No. SKLSP201741) the Natural Science Basic Research Plan in Shaanxi Province, China (Grant No. 2016KJXX-09), and the Fundamental Research Funds for the Central Universities, China (Grant No. 3102015BJ(II)ZS014).

[Childhood vaccines and autism--much ado about nothing?].

PubMed

Solt, Ido; Bornstein, Jacob

2010-04-01

The increased diagnoses of autism and developmental disorders in recent decades, together with the childhood vaccination program, has led to the hypothesis that vaccination in general, and the measles, mumps, and rubella virus live vaccine, and vaccines that contain mercury, in particular, cause autism. It has been hypothesized that intestinal infection caused by live virus vaccines change the permeability of the intestinal wall, and subsequently, the passage of peptides through the intestinal wall to the blood, and from there to the brain. It has been suggested that the accumulation of these peptides in the central nervous system causes autism. Studies that investigated this theory did not find an association between vaccine administration and between digestive system symptoms and autism. According to a second hypothesis, an organomercury compound (Thimerosal), used as a preservative in vaccines that do not include live viruses, is a cause of autism. Like the former, this hypothesis has been well researched, and refuted. Some studies have in fact found an increase in autism diagnosis among children who were vaccinated after Thimerosal was removed from the vaccine preparation. Recent studies have refuted the theory that the consecutive administration of vaccines weakens the young immune system in children, and leads to an autoimmune process that causes autism. The etiology of autism is still unknown, with research continuing from different directions. The extensive research conducted so far indicates that childhood vaccination is not a cause of the sharp increase in autism diagnoses in recent decades.

National Dam Safety Program. Roxbury Dam (Inventory Number 788) Delaware River Basin, Delaware County, New York. Phase I Inspection Report,

DTIC Science & Technology

1980-05-21

service spillway was analyzed as a sharp - crested weir with:.a discharge coefficient (c) of 3.1. The auxiliary spillway channel was analyzed as a broad ...upstream portion of this channel is a concrete structure which forms a 27.4 foot long rectangular weir . There is a 5 foot vertical drop beyond the crest ...I on 1.5 Crest Width (ft) 12 g. Service Spillway Type: Concrete channel-rectangular weir . Five foot vertical drop beyond crest . Masonry and laid up

Experimental and computational flow-field results for an all-body hypersonic aircraft

NASA Technical Reports Server (NTRS)

Cleary, Joseph W.

1989-01-01

A comprehensive test program is defined which is being implemented in the NASA/Ames 3.5 foot Hypersonic Wind Tunnel for obtaining data on a generic all-body hypersonic vehicle for computational fluid dynamics (CFD) code validation. Computational methods (approximate inviscid methods and an upwind parabolized Navier-Stokes code) currently being applied to the all-body model are outlined. Experimental and computational results on surface pressure distributions and Pitot-pressure surveys for the basic sharp-nose model (without control surfaces) at a free-stream Mach number of 7 are presented.

Workplace safety and health for the veterinary health care team.

PubMed

Gibbins, John D; MacMahon, Kathleen

2015-03-01

Veterinary clinic employers have a legal and ethical responsibility to provide a safe and healthy workplace. Clinic members are responsible for consistently using safe practices and procedures set up by their employer. Development and implementation of a customized comprehensive workplace safety and health program is emphasized, including an infection control plan. Occupational safety and health regulations are reviewed. The hazards of sharps, animal bites and scratches, and drugs are discussed. Strategies to prevent or minimize adverse health effects and resources for training and education are provided. Published by Elsevier Inc.

Smartphone Microscopy of Parasite Eggs Accumulated into a Single Field of View.

PubMed

Sowerby, Stephen J; Crump, John A; Johnstone, Maree C; Krause, Kurt L; Hill, Philip C

2016-01-01

A Nokia Lumia 1020 cellular phone (Microsoft Corp., Auckland, New Zealand) was configured to image the ova of Ascaris lumbricoides converged into a single field of view but on different focal planes. The phone was programmed to acquire images at different distances and, using public domain computer software, composite images were created that brought all the eggs into sharp focus. This proof of concept informs a framework for field-deployable, point of care monitoring of soil-transmitted helminths. © The American Society of Tropical Medicine and Hygiene.

Proceedings of the Army Science Conference (14th) Held at the United States Military Academy, West Point, New York on 19-21 June 1984. Volume 3. Principal Authors P through Z.

DTIC Science & Technology

1984-06-22

relesel Distibution Unlimited .- -. POHLMANN, SHARP, AND WOOD systems is providing insight into the dynamics of molecular states in such fundamental ...ARR, Wash, DC 20310 Combat Support Systems Directorate, ATTN: DAMA-CSZ, Wash, DC 20310 Materiel Plans & Programs Directorate, ATTN: DAMA-PPF, Wash...DC 20310 Weapons Systems Directorate, ATTN: DAMA-WSZ, Wash, DC 20310 Office of the Chief of Engineers, ATTN: DAEN-RDZ-A, Wash, DC 20314 Office of the

Apparatus Tests Thermocouples For Seebeck Inhomogeneity

NASA Technical Reports Server (NTRS)

Burkett, Cecil G., Jr.; Bauserman, Willard A., Jr.; West, James W.

1995-01-01

Automated apparatus reveals sources of error not revealed in calibration. Computer-controlled apparatus detects and measures Seebeck inhomogeneities in sheathed thermocouples. Measures thermocouple output voltage as function of position of probe along sharp gradient of temperature. Abnormal variations in voltage-versus-position data indicative of Seebeck inhomogeneities. Prototype for development of standard method and equipment for routine acceptance/rejection testing of sheathed thermocouples in industrial and research laboratories.

Do Humans Have Two Systems to Track Beliefs and Belief-Like States?

ERIC Educational Resources Information Center

Apperly, Ian A.; Butterfill, Stephen A.

2009-01-01

The lack of consensus on how to characterize humans' capacity for belief reasoning has been brought into sharp focus by recent research. Children fail critical tests of belief reasoning before 3 to 4 years of age (H. Wellman, D. Cross, & J. Watson, 2001; H. Wimmer & J. Perner, 1983), yet infants apparently pass false-belief tasks at 13 or 15…

Federal Research and Development Contract Trends and the Supporting Industrial Base, 2000-2014

DTIC Science & Technology

2016-04-30

Homeland Security, and government-wide services contracting trends; sourcing policy and cost estimation methodologies; and recent U.S. Army modernization ...been fears that the sharp downturn in federal contract obligations would disproportionately impact the R&D contracting portfolios within individual...329 - contracting portfolios , and the industrial base that supports those efforts, within each R&D contracting agency. The main finding of this

Implementation of Structures in the CMS: Part 2, Weir

DTIC Science & Technology

2013-08-01

sharp - crested weir , it is between 0.55 and 0.58, and a broad - crested ...implementation, different weir coefficients are specified for the weir structure design, sharp - crested or broad - crested weir . The lowest value in the...coefficient range is used for the sharp - crested (0.55) and broad - crested (0.46) weir , respectively; the flux comparison between these two

78 FR 60376 - Proposed Collection: Direct Deposit Sign-Up Form

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

..., as required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A... Fiscal Service, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp@bpd.... Sharp, Bureau of the Fiscal Service, 200 Third Street A4-A, Parkersburg, WV 26106-1328, (304) 480- 8150...

77 FR 38394 - Proposed Collection: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A). Currently the... of the Public Debt, Bruce A. Sharp, 200 Third Street A4-A, Parkersburg, WV 26106-1328, or bruce.sharp.... Sharp, Bureau of the Public Debt, 200 Third Street A4-A, Parkersburg, WV 26106-1328, (304) 480-8150...

Consideration of vision and picture quality: psychological effects induced by picture sharpness

NASA Astrophysics Data System (ADS)

Kusaka, Hideo

1989-08-01

A psychological hierarchy model of human vision(1)(2) suggests that the visual signals are processed in a serial manner from lower to higher stages: that is "sensation" - "perception" - "emotion." For designing a future television system, it is important to find out what kinds of physical factors affect the "emotion" experienced by an observer in front of the display. This paper describes the psychological effects induced by the sharpness of the picture. The subjective picture quality was evaluated for the same pictures with five different levels of sharpness. The experiment was performed on two kinds of printed pictures: (A) a woman's face, and (B) a town corner. From these experiments, it was found that the amount of high-frequency peaking (physical value of the sharpness) which psychologically gives the best picture quality, differs between pictures (A) and (B). That is, the optimum picture sharpness differs depending on the picture content. From these results, we have concluded that the psychophysical sharpness of the picture is not only determined at the stage of "perception" (e.g., resolution or signal to noise ratio, which everyone can judge immediately), but also at the stage of "emotion" (e.g., sensation of reality or beauty).

Objective assessment of knife sharpness over a working day cutting meat.

PubMed

Savescu, Adriana; Cuny-Guerrier, Aude; Wild, Pascal; Reno, Gilles; Aublet-Cuvelier, Agnès; Claudon, Laurent

2018-04-01

Knife sharpness is one of multiple factors involved in musculoskeletal disorders in industrial meat cutting. The aim of this study was to objectively evaluate, in real working situations, how knife sharpness changed over a working day cutting meat, and to analyse the impact of sharpening, steeling and meat-cutting activities on these variations. Twenty-two meat-cutting workers from three different companies participated in the study. The methods included measurements of knife sharpness in relation to real work situations and consideration of the way meat-cutting and sharpening operations were organised. Results showed that the type of meat-cutting activities, the steeling strategy adopted by the worker, including the types of tool used, and the overall organisation of the sharpening task all had a significant influence on how knife sharpness evolved over a 2-h period and over an entire working day. To improve MSD prevention, sharpening and steeling operations should not be considered as independent activities, but taken into account as a continuity of working actions. Appropriate assessment of knife sharpness by meat cutters affects how they organise meat-cutting and sharpening tasks. Copyright © 2017 Elsevier Ltd. All rights reserved.

The current status of immunotoxins: an overview of experimental and clinical studies as presented at the Third International Symposium on Immunotoxins.

PubMed

Uckun, F M; Frankel, A

1993-02-01

The Third International Symposium on Immunotoxins was held on June 19-21, 1992 in Orlando, Florida. This symposium was sponsored by NATO, NIH, Pierce Chemical Company, Walt Disney Cancer Institute at Florida Hospital, Duke Comprehensive Cancer Center, Xoma, Immunogen, Seragen, Bristol-Myers Squibb, Chiron, Ortho Biotech, Upjohn, Merck Sharp & Dohme Research Laboratories, Abbot Laboratories, Lilly Research Laboratories, and Evans & Sutherland. The Pierce Immunotoxin Award which recognizes outstanding contributions to immunotoxin research and development, was presented to Drs David FitzGerald, Fatih Uckun, David Eisenberg, and Ira Wool, for their contributions to the immunotoxin field.

The stratigraphy and evolution of lower Mount Sharp from spectral, morphological, and thermophysical orbital data sets.

PubMed

Fraeman, A A; Ehlmann, B L; Arvidson, R E; Edwards, C S; Grotzinger, J P; Milliken, R E; Quinn, D P; Rice, M S

2016-09-01

We have developed a refined geologic map and stratigraphy for lower Mount Sharp using coordinated analyses of new spectral, thermophysical, and morphologic orbital data products. The Mount Sharp group consists of seven relatively planar units delineated by differences in texture, mineralogy, and thermophysical properties. These units are (1-3) three spatially adjacent units in the Murray formation which contain a variety of secondary phases and are distinguishable by thermal inertia and albedo differences, (4) a phyllosilicate-bearing unit, (5) a hematite-capped ridge unit, (6) a unit associated with material having a strongly sloped spectral signature at visible near-infrared wavelengths, and (7) a layered sulfate unit. The Siccar Point group consists of the Stimson formation and two additional units that unconformably overlie the Mount Sharp group. All Siccar Point group units are distinguished by higher thermal inertia values and record a period of substantial deposition and exhumation that followed the deposition and exhumation of the Mount Sharp group. Several spatially extensive silica deposits associated with veins and fractures show that late-stage silica enrichment within lower Mount Sharp was pervasive. At least two laterally extensive hematitic deposits are present at different stratigraphic intervals, and both are geometrically conformable with lower Mount Sharp strata. The occurrence of hematite at multiple stratigraphic horizons suggests redox interfaces were widespread in space and/or in time, and future measurements by the Mars Science Laboratory Curiosity rover will provide further insights into the depositional settings of these and other mineral phases.

Secure Container For Discarded Hypodermic Needles

NASA Technical Reports Server (NTRS)

Lee, Angelene M.

1992-01-01

Container designed for safe retention of discarded blood-collecting hypodermic needles and similar sharp objects used in life-science experiments aboard spacecraft. Needles inserted through self-closing lid and retained magnetically. They are inserted, sharp end first, through spring-loaded flap. Long needles and needles on syringes cannot turn around in container. Can be emptied, cleaned, and reused. Used on Earth to provide unusually secure containment of sharp objects.

Injuries caused by sharp instruments among healthcare workers--international and Polish perspectives.

PubMed

Goniewicz, Mariusz; Włoszczak-Szubzda, Anna; Niemcewicz, Marcin; Witt, Magdalena; Marciniak-Niemcewicz, Anna; Jarosz, Mirosław Jerzy

2012-01-01

Health care workers (HCW) worldwide are especially exposed to injury by sharp instruments in the course of their duty. The most often executed procedures with injury risk are: intramuscular or subcutaneous injection (22%), taking blood samples, or during intravenous cannulation (20%), and repeatedly replacing the cap on an already used needle (30%). Even a minor sharp injury with only a small loss of blood carries the risk of transfer of over 20 pathogens: Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), HIV/AIDS virus, malaria, syphilis, tuberculosis, brucellosis, herpes virus and diphtheria. The World Health Organization (WHO) estimates that more than two million health care workers experience the stressful event of a percutaneous injury with a contaminated sharp object each year (25-90% of them, however, remain unreported). These exposures result in about 16,000 infections with HCV, 66,000 with HBV and about 1,000 (200-5000) with HIV, which lead to about 1,100 deaths or significant disability. Exposures to sharp injuries and their consequences are highly preventable through simple interventions, such as HBV vaccination, education and providing containers for sharp instruments. Specific guidelines, similar to the American Occupational Safety and Health Administration (OSHA) regulations that have lowered by up to 88% of needle stabbing incidents, should be introduced by the European Union (EU) and other countries. The results of a review of reports leads to the following conclusions: 1) elaboration and implementation of new State regulations, especially in EU countries and in countries where such regulations do not exist; 2) the training of health care personnel should always be undertaken for new employees, and periodically for those already employed; 3) periodical control by appointed inspectors of knowledge of procedures for the prevention of injuries by sharp instruments among health care workers; 4) introducing and training in the use of equipment, which can prevent the sharp injuries; 5) an advanced monitoring system of sharp injuries sustained by worker should also be introduced. Successful implementation of these prevention measures will result in progress for public health and HCW's health and safety.

Next generation fire suppressants

NASA Technical Reports Server (NTRS)

Brown, Jerry A.

1995-01-01

Spectrex, Inc., located in Cedar Grove, NJ is a manufacturer of fire detection and suppression equipment. Spectrex is one of the original pioneers in high speed fire detection and suppression systems for combat vehicles. Spectrex has installed fire suppressions systems in thousands of combat vehicles and ships throughout the world. Additionally, they manufacture flame explosion detectors, ship damage control systems, and optical gas and vapor detectors. The culmination of several years of research and development has recently produced an innovative electro-optical continuous monitoring systems called SharpEye 20/20I IR(sup 3) and SAFEYE that provide fast and reliable gas, vapor, aerosol, flame, and explosion detection. SharpEye 20/20I IR(sup 3) is a self-contained triple spectrum flame detector which scans for oscillating IR radiation (1 to 10 Hz) in the spectral bands ranging from 4.0 to 5.0 microns and uses programmed algorithms to check the ratio and correlation of data received by the three sensors to make the system highly immune to false alarms. It is extremely sensitive as it can detect a 1 x 1 square foot gasoline pan fire at 200 feet in less than 3 seconds. The sensitivity is user programmable, offering 4 ranges of detection. SAFEYE is comprised of a selected number of multispectral ban microprocessors controlled detectors which are in communication with one or more radiation sources that is projected along a 600 feet optical path. The signals from the selected narrow bands are processed and analyzed by highly sophisticated algorithms. It is ideal for high risk, remote, large areas such as petroleum and chemical manufacturing sites, waste dumps, aircraft cargo bays, and ship compartments. The SAFEYE will perform direct readings of the presence or rate of rise of concentrations of gases, vapors, or aerosols at the range of parts per million and provide alarms at various set points at different levels of concentrations.

Occupational safety among dental health-care workers.

PubMed

Shimoji, Shigehiro; Ishihama, Kohji; Yamada, Hidefumi; Okayama, Masaki; Yasuda, Kouichi; Shibutani, Tohru; Ogasawara, Tadashi; Miyazawa, Hiroo; Furusawa, Kiyofumi

2010-01-01

Compared to other health-care workers, dental health-care workers come in close contact with patients and use a variety of sharp and high-speed rotating instruments. It is important to understand the characteristics of the occupational accidents that occur. We reviewed incident reports from April 1, 2005, to March 31, 2010, at Matsumoto Dental University Hospital. In addition, questionnaires dealing with identification of occupational safety issues, especially splash exposures, were conducted for dentists, dental hygienists, and nurses. Thirty-two occupational injuries were reported during the study period, including 23 sharp instrument injuries (71.9%), 6 splash exposures (18.8%), and 3 others. Of the six splash exposures, only two cases involved potential contamination with blood or other potentially infectious patient material. Of the 66 workers who experienced sharps injuries, 20 workers (30.3%, 20/66) reported them to the hospital work safety team. The questionnaire revealed high incident of splash exposures and conjunctiva exposures: 87.9% (51/58) and 60.3% (35/58) in dentists and 88.6% (39/44) and 61.4% (27/44) in dental hygienists. The compliance rate for routine use of protective eyewear was 60.3% (35/58) for dentists and 34.1% (15/44) for hygienists. Of the presented informational items included in the questionnaire, those that strongly persuaded respondents to use protective eyewear were 'splatters from the patient's mouth contain blood' (90%, 99/110) and 'dental operations at our clinic are performed based only on a questionnaire without serious examinations for HBV, HCV, and HIV' (71.8%, 79/110). The reason of low compliance of protective eyewear among dentists might relate to fine dental procedures. Appropriate information is important for the motive of wearing personal protective equipment, and an early educational program may have a potential to increase compliance with the use of that equipment.

Surface-Wave Pulse Routing around Sharp Right Angles

NASA Astrophysics Data System (ADS)

Gao, Z.; Xu, H.; Gao, F.; Zhang, Y.; Luo, Y.; Zhang, B.

2018-04-01

Surface-plasmon polaritons (SPPs), or localized electromagnetic surface waves propagating on a metal-dielectric interface, are deemed promising information carriers for future subwavelength terahertz and optical photonic circuitry. However, surface waves fundamentally suffer from scattering loss when encountering sharp corners in routing and interconnection of photonic signals. Previous approaches enabling scattering-free surface-wave guidance around sharp corners are limited to either volumetric waveguide environments or extremely narrow bandwidth, being unable to guide a surface-wave pulse (SPP wave packet) on an on-chip platform. Here, in a surface-wave band-gap crystal implemented on a single metal surface, we demonstrate in time-domain routing a surface-wave pulse around multiple sharp right angles without perceptible scattering. Our work not only offers a solution to on-chip surface-wave pulse routing along an arbitrary path, but it also provides spatiotemporal information on the interplay between surface-wave pulses and sharp corners, both of which are desirable in developing high-performance large-scale integrated photonic circuits.

A real-time evaluation and demonstration of strategies for 'Over-The-Loop' ensemble streamflow forecasting in US watersheds

NASA Astrophysics Data System (ADS)

Wood, Andy; Clark, Elizabeth; Mendoza, Pablo; Nijssen, Bart; Newman, Andy; Clark, Martyn; Nowak, Kenneth; Arnold, Jeffrey

2017-04-01

Many if not most national operational streamflow prediction systems rely on a forecaster-in-the-loop approach that require the hands-on-effort of an experienced human forecaster. This approach evolved from the need to correct for long-standing deficiencies in the models and datasets used in forecasting, and the practice often leads to skillful flow predictions despite the use of relatively simple, conceptual models. Yet the 'in-the-loop' forecast process is not reproducible, which limits opportunities to assess and incorporate new techniques systematically, and the effort required to make forecasts in this way is an obstacle to expanding forecast services - e.g., though adding new forecast locations or more frequent forecast updates, running more complex models, or producing forecast and hindcasts that can support verification. In the last decade, the hydrologic forecasting community has begun develop more centralized, 'over-the-loop' systems. The quality of these new forecast products will depend on their ability to leverage research in areas including earth system modeling, parameter estimation, data assimilation, statistical post-processing, weather and climate prediction, verification, and uncertainty estimation through the use of ensembles. Currently, many national operational streamflow forecasting and water management communities have little experience with the strengths and weaknesses of over-the-loop approaches, even as such systems are beginning to be deployed operationally in centers such as ECMWF. There is thus a need both to evaluate these forecasting advances and to demonstrate their potential in a public arena, raising awareness in forecast user communities and development programs alike. To address this need, the US National Center for Atmospheric Research is collaborating with the University of Washington, the Bureau of Reclamation and the US Army Corps of Engineers, using the NCAR 'System for Hydromet Analysis Research and Prediction Applications' (SHARP) to implement, assess and demonstrate real-time over-the-loop ensemble flow forecasts in a range of US watersheds. The system relies on fully ensemble techniques, including: an 100-member ensemble of meteorological model forcings and an ensemble particle filter data assimilation for initializing watershed states; analog/regression-based downscaling of ensemble weather forecasts from GEFS; and statistical post-processing of ensemble forecast outputs, all of which run in real-time within a workflow managed by ECWMF's ecFlow libraries over large US regional domains. We describe SHARP and present early hindcast and verification results for short to seasonal range streamflow forecasts in a number of US case study watersheds.

16 CFR 1500.48 - Technical requirements for determining a sharp point in toys and other articles intended for use...

Code of Federal Regulations, 2012 CFR

2012-01-01

... sharp point in toys and other articles intended for use by children under 8 years of age. 1500.48... requirements for determining a sharp point in toys and other articles intended for use by children under 8... intended for use by children under 8 years of age, and such points exposed in normal use or as a result of...

16 CFR § 1500.48 - Technical requirements for determining a sharp point in toys and other articles intended for use...

Code of Federal Regulations, 2013 CFR

2013-01-01

... sharp point in toys and other articles intended for use by children under 8 years of age. § 1500.48... by children under 8 years of age. (a) Objective. The sharp point test prescribed by paragraph (d) of... and other articles intended for use by children under 8 years of age, and such points exposed in...

16 CFR 1500.48 - Technical requirements for determining a sharp point in toys and other articles intended for use...

Code of Federal Regulations, 2011 CFR

2011-01-01

... sharp point in toys and other articles intended for use by children under 8 years of age. 1500.48... requirements for determining a sharp point in toys and other articles intended for use by children under 8... intended for use by children under 8 years of age, and such points exposed in normal use or as a result of...

16 CFR 1500.48 - Technical requirements for determining a sharp point in toys and other articles intended for use...

Code of Federal Regulations, 2014 CFR

2014-01-01

... sharp point in toys and other articles intended for use by children under 8 years of age. 1500.48... requirements for determining a sharp point in toys and other articles intended for use by children under 8... intended for use by children under 8 years of age, and such points exposed in normal use or as a result of...

Investigation of micromixing by acoustically oscillated sharp-edges

PubMed Central

Nama, Nitesh; Huang, Po-Hsun; Huang, Tony Jun; Costanzo, Francesco

2016-01-01

Recently, acoustically oscillated sharp-edges have been utilized to achieve rapid and homogeneous mixing in microchannels. Here, we present a numerical model to investigate acoustic mixing inside a sharp-edge-based micromixer in the presence of a background flow. We extend our previously reported numerical model to include the mixing phenomena by using perturbation analysis and the Generalized Lagrangian Mean (GLM) theory in conjunction with the convection-diffusion equation. We divide the flow variables into zeroth-order, first-order, and second-order variables. This results in three sets of equations representing the background flow, acoustic response, and the time-averaged streaming flow, respectively. These equations are then solved successively to obtain the mean Lagrangian velocity which is combined with the convection-diffusion equation to predict the concentration profile. We validate our numerical model via a comparison of the numerical results with the experimentally obtained values of the mixing index for different flow rates. Further, we employ our model to study the effect of the applied input power and the background flow on the mixing performance of the sharp-edge-based micromixer. We also suggest potential design changes to the previously reported sharp-edge-based micromixer to improve its performance. Finally, we investigate the generation of a tunable concentration gradient by a linear arrangement of the sharp-edge structures inside the microchannel. PMID:27158292

Investigation of micromixing by acoustically oscillated sharp-edges.

PubMed

Nama, Nitesh; Huang, Po-Hsun; Huang, Tony Jun; Costanzo, Francesco

2016-03-01

Recently, acoustically oscillated sharp-edges have been utilized to achieve rapid and homogeneous mixing in microchannels. Here, we present a numerical model to investigate acoustic mixing inside a sharp-edge-based micromixer in the presence of a background flow. We extend our previously reported numerical model to include the mixing phenomena by using perturbation analysis and the Generalized Lagrangian Mean (GLM) theory in conjunction with the convection-diffusion equation. We divide the flow variables into zeroth-order, first-order, and second-order variables. This results in three sets of equations representing the background flow, acoustic response, and the time-averaged streaming flow, respectively. These equations are then solved successively to obtain the mean Lagrangian velocity which is combined with the convection-diffusion equation to predict the concentration profile. We validate our numerical model via a comparison of the numerical results with the experimentally obtained values of the mixing index for different flow rates. Further, we employ our model to study the effect of the applied input power and the background flow on the mixing performance of the sharp-edge-based micromixer. We also suggest potential design changes to the previously reported sharp-edge-based micromixer to improve its performance. Finally, we investigate the generation of a tunable concentration gradient by a linear arrangement of the sharp-edge structures inside the microchannel.

Sample Skewness as a Statistical Measurement of Neuronal Tuning Sharpness

PubMed Central

Samonds, Jason M.; Potetz, Brian R.; Lee, Tai Sing

2014-01-01

We propose using the statistical measurement of the sample skewness of the distribution of mean firing rates of a tuning curve to quantify sharpness of tuning. For some features, like binocular disparity, tuning curves are best described by relatively complex and sometimes diverse functions, making it difficult to quantify sharpness with a single function and parameter. Skewness provides a robust nonparametric measure of tuning curve sharpness that is invariant with respect to the mean and variance of the tuning curve and is straightforward to apply to a wide range of tuning, including simple orientation tuning curves and complex object tuning curves that often cannot even be described parametrically. Because skewness does not depend on a specific model or function of tuning, it is especially appealing to cases of sharpening where recurrent interactions among neurons produce sharper tuning curves that deviate in a complex manner from the feedforward function of tuning. Since tuning curves for all neurons are not typically well described by a single parametric function, this model independence additionally allows skewness to be applied to all recorded neurons, maximizing the statistical power of a set of data. We also compare skewness with other nonparametric measures of tuning curve sharpness and selectivity. Compared to these other nonparametric measures tested, skewness is best used for capturing the sharpness of multimodal tuning curves defined by narrow peaks (maximum) and broad valleys (minima). Finally, we provide a more formal definition of sharpness using a shape-based information gain measure and derive and show that skewness is correlated with this definition. PMID:24555451

The stratigraphy and evolution of lower Mount Sharp from spectral, morphological, and thermophysical orbital data sets

PubMed Central

Ehlmann, B. L.; Arvidson, R. E.; Edwards, C. S.; Grotzinger, J. P.; Milliken, R. E.; Quinn, D. P.; Rice, M. S.

2016-01-01

Abstract We have developed a refined geologic map and stratigraphy for lower Mount Sharp using coordinated analyses of new spectral, thermophysical, and morphologic orbital data products. The Mount Sharp group consists of seven relatively planar units delineated by differences in texture, mineralogy, and thermophysical properties. These units are (1–3) three spatially adjacent units in the Murray formation which contain a variety of secondary phases and are distinguishable by thermal inertia and albedo differences, (4) a phyllosilicate‐bearing unit, (5) a hematite‐capped ridge unit, (6) a unit associated with material having a strongly sloped spectral signature at visible near‐infrared wavelengths, and (7) a layered sulfate unit. The Siccar Point group consists of the Stimson formation and two additional units that unconformably overlie the Mount Sharp group. All Siccar Point group units are distinguished by higher thermal inertia values and record a period of substantial deposition and exhumation that followed the deposition and exhumation of the Mount Sharp group. Several spatially extensive silica deposits associated with veins and fractures show that late‐stage silica enrichment within lower Mount Sharp was pervasive. At least two laterally extensive hematitic deposits are present at different stratigraphic intervals, and both are geometrically conformable with lower Mount Sharp strata. The occurrence of hematite at multiple stratigraphic horizons suggests redox interfaces were widespread in space and/or in time, and future measurements by the Mars Science Laboratory Curiosity rover will provide further insights into the depositional settings of these and other mineral phases. PMID:27867788

Determining How to Best Predict Navy Recruiting Using Various Economic Variables

DTIC Science & Technology

2015-03-01

M ., & Ajzen , I . (1975). Belief, attitude, intention and behavior: An introduction to theory and research. Reading, MA: Addison-Wesley. Leonhardt, D... Fishbein & Ajzen , 1975), behavioral intentions are strong predictors of actual behavior. The higher propensity rates are at a given time inherently...J. R., Arkes, J., Fair, C. C., Sharp, J., & Totten, M . (2002). Military recruiting and retention after the fiscal year 2000 military pay (MR-1532-OSD

Medical waste management plan.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, Todd W.; VanderNoot, Victoria A.

2004-12-01

This plan describes the process for managing research generated medical waste at Sandia National Laboratories/California. It applies to operations at the Chemical and Radiation Detection Laboratory (CRDL), Building 968, and other biosafety level 1 or 2 activities at the site. It addresses the accumulation, storage, treatment and disposal of medical waste and sharps waste. It also describes the procedures to comply with regulatory requirements and SNL policies applicable to medical waste.

Solution-processed phase-change VO(2) metamaterials from colloidal vanadium oxide (VO(x)) nanocrystals.

PubMed

Paik, Taejong; Hong, Sung-Hoon; Gaulding, E Ashley; Caglayan, Humeyra; Gordon, Thomas R; Engheta, Nader; Kagan, Cherie R; Murray, Christopher B

2014-01-28

We demonstrate thermally switchable VO2 metamaterials fabricated using solution-processable colloidal nanocrystals (NCs). Vanadium oxide (VOx) NCs are synthesized through a nonhydrolytic reaction and deposited from stable colloidal dispersions to form NC thin films. Rapid thermal annealing transforms the VOx NC thin films into monoclinic, nanocrystalline VO2 thin films that show a sharp, reversible metal-insulator phase transition. Introduction of precise concentrations of tungsten dopings into the colloidal VOx NCs enables the still sharp phase transition of the VO2 thin films to be tuned to lower temperatures as the doping level increases. We fabricate "smart", differentially doped, multilayered VO2 films to program the phase and therefore the metal-insulator behavior of constituent vertically structured layers with temperature. With increasing temperature, we tailored the optical response of multilayered films in the near-IR and IR regions from that of a strong light absorber, in a metal-insulator structure, to that of a Drude-like reflector, characteristic of a pure metallic structure. We demonstrate that nanocrystal-based nanoimprinting can be employed to pattern multilayered subwavelength nanostructures, such as three-dimensional VO2 nanopillar arrays, that exhibit plasmonic dipolar responses tunable with a temperature change.

Nighttime ionospheric D region parameters from VLF phase and amplitude

NASA Astrophysics Data System (ADS)

Thomson, Neil R.; Clilverd, Mark A.; McRae, Wayne M.

2007-07-01

Nighttime ionospheric D region heights and electron densities are determined from an extensive set of VLF radio phase and amplitude observations. The D region parameters are characterized by the traditional H' (height in kilometers) and β (sharpness in km-1) as used by Wait and by the U. S. Navy in their Earth-ionosphere waveguide programs. The VLF measurements were made with several frequencies in the range 10 kHz to 41 kHz on long, mainly all-sea paths, including Omega La Reunion and Omega Argentina to Dunedin, New Zealand, NAU (Puerto Rico) and NAA (Maine, USA) to Cambridge, UK, and NPM (Hawaii) to San Francisco. Because daytime VLF propagation on such paths is readily measured and predicted, the differences between night and day amplitudes and phases were measured and compared with calculations for a range of nighttime ionospheric parameters. This avoided the problem of uncertainties in the transmitter powers. In this way the height, H', and the sharpness, β, when averaged over periods of several days, at least for the midlatitude D region near solar minimum, were found to be 85.1 ± 0.4 km and 0.63 ± 0.04 km-1, respectively.

Implementation of Open-Source Web Mapping Technologies to Support Monitoring of Governmental Schemes

NASA Astrophysics Data System (ADS)

Pulsani, B. R.

2015-10-01

Several schemes are undertaken by the government to uplift social and economic condition of people. The monitoring of these schemes is done through information technology where involvement of Geographic Information System (GIS) is lacking. To demonstrate the benefits of thematic mapping as a tool for assisting the officials in making decisions, a web mapping application for three government programs such as Mother and Child Tracking system (MCTS), Telangana State Housing Corporation Limited (TSHCL) and Ground Water Quality Mapping (GWQM) has been built. Indeed the three applications depicted the distribution of various parameters thematically and helped in identifying the areas with higher and weaker distributions. Based on the three applications, the study tends to find similarities of many government schemes reflecting the nature of thematic mapping and hence deduces to implement this kind of approach for other schemes as well. These applications have been developed using SharpMap Csharp library which is a free and open source mapping library for developing geospatial applications. The study highlights upon the cost benefits of SharpMap and brings out the advantage of this library over proprietary vendors and further discusses its advantages over other open source libraries as well.

Establishing imaging sensor specifications for digital still cameras

NASA Astrophysics Data System (ADS)

Kriss, Michael A.

2007-02-01

Digital Still Cameras, DSCs, have now displaced conventional still cameras in most markets. The heart of a DSC is thought to be the imaging sensor, be it Full Frame CCD, and Interline CCD, a CMOS sensor or the newer Foveon buried photodiode sensors. There is a strong tendency by consumers to consider only the number of mega-pixels in a camera and not to consider the overall performance of the imaging system, including sharpness, artifact control, noise, color reproduction, exposure latitude and dynamic range. This paper will provide a systematic method to characterize the physical requirements of an imaging sensor and supporting system components based on the desired usage. The analysis is based on two software programs that determine the "sharpness", potential for artifacts, sensor "photographic speed", dynamic range and exposure latitude based on the physical nature of the imaging optics, sensor characteristics (including size of pixels, sensor architecture, noise characteristics, surface states that cause dark current, quantum efficiency, effective MTF, and the intrinsic full well capacity in terms of electrons per square centimeter). Examples will be given for consumer, pro-consumer, and professional camera systems. Where possible, these results will be compared to imaging system currently on the market.

Look Sharp While Seeing Sharp

NASA Technical Reports Server (NTRS)

2006-01-01

The two scientists James B. Stephens and Dr. Charles G. Miller were tasked with studying the harmful properties of light in space, as well as the artificial radiation produced during laser and welding work, for the purpose of creating an enhanced means of eye protection in industrial welding applications. While working to apply their space research to these terrestrial applications, Stephens and Miller became engrossed with previously discovered research showing evidence that the eyes of hawks, eagles, and other birds of prey contain unique oil droplets that actually protect them from intensely radiated light rays (blue, violet, ultraviolet) while allowing vision-enhancing light rays (red, orange, green) to pass through. These oil droplets absorb short wavelength light rays which, in turn, reduce glare and provide heightened color contrast and definition for optimal visual acuity. Accordingly, birds of prey possess the ability to distinguish their targeted prey in natural surroundings and from great distances. Pairing the findings from their initial studies with what they learned from the bird studies, the scientists devised a methodology to incorporate the light-filtering/vision-enhancing dual-action benefits into a filtering system, using light-filtering dyes and tiny particles of zinc oxide. (Zinc oxide, which absorbs ultraviolet light, is also found in sunscreen lotions that protect the skin from sunburn.)

Details on Silica-Rich Elk Target near Marias Pass

NASA Image and Video Library

2015-12-17

This image from the Chemistry and Camera (ChemCam) instrument on NASA's Curiosity Mars rover shows detailed texture of a rock target called "Elk" on Mars' Mount Sharp, revealing laminations that are present in much of the Murray Formation geological unit of lower Mount Sharp. Researchers also used ChemCam's laser and spectrometers to assess Elk's composition and found it to be rich in silica. The image covers a patch of rock surface about 2.8 inches (7 centimeters) across. It was taken on May 22, 2015, during the mission's 992nd Martian day, or sol. ChemCam's Remote Micro-Imager camera, on top of Curiosity's mast, captured the image from a distance of about 9 feet (2.75 meters). Annotations in red identify five points on Elk that were hit with ChemCam's laser. Each of the highlighted points is a location where ChemCam fired its laser 30 times to ablate a tiny amount of target material. By analyzing the light emitted from this laser-ablation, researchers can deduce the composition of that point. For some purposes, composition is presented as a combination of the information from multiple points on the same rock. However, using the points individually can track fine-scale variations in targets. http://photojournal.jpl.nasa.gov/catalog/PIA20267

TEA: A Code Calculating Thermochemical Equilibrium Abundances

NASA Astrophysics Data System (ADS)

Blecic, Jasmina; Harrington, Joseph; Bowman, M. Oliver

2016-07-01

We present an open-source Thermochemical Equilibrium Abundances (TEA) code that calculates the abundances of gaseous molecular species. The code is based on the methodology of White et al. and Eriksson. It applies Gibbs free-energy minimization using an iterative, Lagrangian optimization scheme. Given elemental abundances, TEA calculates molecular abundances for a particular temperature and pressure or a list of temperature-pressure pairs. We tested the code against the method of Burrows & Sharp, the free thermochemical equilibrium code Chemical Equilibrium with Applications (CEA), and the example given by Burrows & Sharp. Using their thermodynamic data, TEA reproduces their final abundances, but with higher precision. We also applied the TEA abundance calculations to models of several hot-Jupiter exoplanets, producing expected results. TEA is written in Python in a modular format. There is a start guide, a user manual, and a code document in addition to this theory paper. TEA is available under a reproducible-research, open-source license via https://github.com/dzesmin/TEA.

Indian pharmaceutical patent prosecution: The changing role of Section 3(d).

PubMed

Sampat, Bhaven N; Shadlen, Kenneth C

2018-01-01

India, like many developing countries, only recently began to grant pharmaceutical product patents. Indian patent law includes a provision, Section 3(d), which tries to limit grant of "secondary" pharmaceutical patents, i.e. patents on new forms of existing molecules and drugs. Previous research suggests the provision was rarely used against secondary applications in the years immediately following its enactment, and where it was, was redundant to other aspects of the patent law, raising concerns that 3(d) was being under-utilized by the Indian Patent Office. This paper uses a novel data source, the patent office's first examination reports, to examine changes in the use of the provision. We find a sharp increase over time in the use of Section 3(d), including on the main claims of patent applications, though it continues to be used in conjunction with other types of objections to patentability. More surprisingly, see a sharp increase in the use of the provision against primary patent applications, contrary to its intent, raising concerns about potential over-utilization.

Involvement of Mossy Cells in Sharp Wave-Ripple Activity In Vitro.

PubMed

Swaminathan, Aarti; Wichert, Ines; Schmitz, Dietmar; Maier, Nikolaus

2018-05-29

The role of mossy cells (MCs) of the hippocampal dentate area has long remained mysterious. Recent research has begun to unveil their significance in spatial computation of the hippocampus. Here, we used an in vitro model of sharp wave-ripple complexes (SWRs), which contribute to hippocampal memory formation, to investigate MC involvement in this fundamental population activity. We find that a significant fraction of MCs (∼47%) is recruited into the active neuronal network during SWRs in the CA3 area. Moreover, MCs receive pronounced, ripple-coherent, excitatory and inhibitory synaptic input. Finally, we find evidence for SWR-related synaptic activity in granule cells that is mediated by MCs. Given the widespread connectivity of MCs within and between hippocampi, our data suggest a role for MCs as a hub functionally coupling the CA3 and the DG during ripple-associated computations. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Kitchen knives and homicide: a systematic study of people charged with murder in the Lothian and Borders region of Scotland.

PubMed

Kidd, S H; Hughes, N S; Crichton, J H M

2014-07-01

A recent English study demonstrated high rates of kitchen knife use in homicides by mentally disordered offenders subject to independent inquiries. Everyone accused of homicide in Scotland undergoes psychiatric examination; all such evaluations in a Scottish region between 2006 and 2011 were systematically analysed to identify homicide characteristics. It was hypothesised that kitchen knives would be the commonest sharp instruments used, and would be associated with unplanned domestic homicide against known victims, with no independent association with mental disorder. Kitchen knives were used in 32 of 55 homicides: 94% of 34 sharp object homicides (p < 0.05). No independent association was found between kitchen knife use and planning, location, relationship, intoxication or mental disorder. Kitchen knife use in homicide appears to be a significant public health issue, and not only in the mentally disordered population. Research is recommended into kitchen knife use in non-fatal violence, and weapon control in populations at increased risk of knife violence.

TEA: A CODE CALCULATING THERMOCHEMICAL EQUILIBRIUM ABUNDANCES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blecic, Jasmina; Harrington, Joseph; Bowman, M. Oliver, E-mail: jasmina@physics.ucf.edu

2016-07-01

We present an open-source Thermochemical Equilibrium Abundances (TEA) code that calculates the abundances of gaseous molecular species. The code is based on the methodology of White et al. and Eriksson. It applies Gibbs free-energy minimization using an iterative, Lagrangian optimization scheme. Given elemental abundances, TEA calculates molecular abundances for a particular temperature and pressure or a list of temperature–pressure pairs. We tested the code against the method of Burrows and Sharp, the free thermochemical equilibrium code Chemical Equilibrium with Applications (CEA), and the example given by Burrows and Sharp. Using their thermodynamic data, TEA reproduces their final abundances, but withmore » higher precision. We also applied the TEA abundance calculations to models of several hot-Jupiter exoplanets, producing expected results. TEA is written in Python in a modular format. There is a start guide, a user manual, and a code document in addition to this theory paper. TEA is available under a reproducible-research, open-source license via https://github.com/dzesmin/TEA.« less

X-ray crystallography

NASA Technical Reports Server (NTRS)

2001-01-01

X-rays diffracted from a well-ordered protein crystal create sharp patterns of scattered light on film. A computer can use these patterns to generate a model of a protein molecule. To analyze the selected crystal, an X-ray crystallographer shines X-rays through the crystal. Unlike a single dental X-ray, which produces a shadow image of a tooth, these X-rays have to be taken many times from different angles to produce a pattern from the scattered light, a map of the intensity of the X-rays after they diffract through the crystal. The X-rays bounce off the electron clouds that form the outer structure of each atom. A flawed crystal will yield a blurry pattern; a well-ordered protein crystal yields a series of sharp diffraction patterns. From these patterns, researchers build an electron density map. With powerful computers and a lot of calculations, scientists can use the electron density patterns to determine the structure of the protein and make a computer-generated model of the structure. The models let researchers improve their understanding of how the protein functions. They also allow scientists to look for receptor sites and active areas that control a protein's function and role in the progress of diseases. From there, pharmaceutical researchers can design molecules that fit the active site, much like a key and lock, so that the protein is locked without affecting the rest of the body. This is called structure-based drug design.

Design and experimentation of an empirical multistructure framework for accurate, sharp and reliable hydrological ensembles

NASA Astrophysics Data System (ADS)

Seiller, G.; Anctil, F.; Roy, R.

2017-09-01

This paper outlines the design and experimentation of an Empirical Multistructure Framework (EMF) for lumped conceptual hydrological modeling. This concept is inspired from modular frameworks, empirical model development, and multimodel applications, and encompasses the overproduce and select paradigm. The EMF concept aims to reduce subjectivity in conceptual hydrological modeling practice and includes model selection in the optimisation steps, reducing initial assumptions on the prior perception of the dominant rainfall-runoff transformation processes. EMF generates thousands of new modeling options from, for now, twelve parent models that share their functional components and parameters. Optimisation resorts to ensemble calibration, ranking and selection of individual child time series based on optimal bias and reliability trade-offs, as well as accuracy and sharpness improvement of the ensemble. Results on 37 snow-dominated Canadian catchments and 20 climatically-diversified American catchments reveal the excellent potential of the EMF in generating new individual model alternatives, with high respective performance values, that may be pooled efficiently into ensembles of seven to sixty constitutive members, with low bias and high accuracy, sharpness, and reliability. A group of 1446 new models is highlighted to offer good potential on other catchments or applications, based on their individual and collective interests. An analysis of the preferred functional components reveals the importance of the production and total flow elements. Overall, results from this research confirm the added value of ensemble and flexible approaches for hydrological applications, especially in uncertain contexts, and open up new modeling possibilities.

Sediment Scaling for Mud Mountain Fish Barrier Structure

DTIC Science & Technology

2017-06-28

2nd Int. Conf. on the Application of Physical Modeling to Port and Coastal Protection – Coastlab ’08, International Association for Hydro...Structure by Jeremy A. Sharp, Gary L. Brown, and Gary L. Bell PURPOSE: This Coastal and Hydraulics Laboratory technical note describes the process of... Coastal and Hydraulics Laboratory. Questions about this technical note can be addressed to Mr. Sharp at 601-634-4212 or Jeremy.A.Sharp@usace.army.mil

A faunistic study of genus Chasmogenus Sharp, 1882 of China (Coleoptera, Hydrophilidae).

PubMed

Jia, Fenglong; Tang, Yu-Dan

2018-01-01

Chasmogenus Sharp, 1882 is newly reported from the Chinese Mainland. A new species, C. parorbus sp. n. , is described from China (Yunnan). Chasmogenus orbus Watanabe, 1987 is reported from Hong Kong, the first record outside Japan. Chasmogenus abnormalis (Sharp, 1890) is reported from the Chinese mainland for the first time. The male genitalia of each species are illustrated. A key to the Chinese species of the genus is provided.

Novel Laser-Based Technique for Measurements of Primary Atomization Characteristics of Liquid Jets

DTIC Science & Technology

2012-08-22

worth noting that round supercavitating nozzles were used that had sharp edged inlets and exits, with length-to-diameter ratios smaller than 3. This...noting that round supercavitating nozzles were used that had sharp edged inlets and exits, with length-to-diameter ratios smaller than 3. This...breakup. It is worth noting that round supercavitating nozzles were used that had sharp edged inlets and exits, with length-to-diameter ratios

Occurrence of Greater Sage-Grouse X Sharp-tailed Grouse hybrids in Alberta

USGS Publications Warehouse

Aldridge, Cameron L.; Oyler-McCance, S.J.; Brigham, R.M.

2001-01-01

Two distinct grouse were regularly observed at two Greater Sage-Grouse (Centrocercus urophasianus) leks in both 1999 and 2000 in southeastern Alberta. Physically and behaviorally, the birds exhibited characteristics of both Greater Sage-Grouse and Sharp-tailed Grouse (Tympanuchus phasianellus), suggesting they were hybrids. DNA analyses of blood and feather samples indicated that both birds were males with Greater Sage-Grouse mothers and thus, fathers that were likely Sharp-tailed Grouse.

Testing local-realism and macro-realism under generalized dichotomic measurements

NASA Astrophysics Data System (ADS)

Das, Debarshi; Mal, Shiladitya; Home, Dipankar

2018-04-01

Generalized quantum measurements with two outcomes are fully characterized by two real parameters, dubbed as sharpness parameter and biasedness parameter and they can be linked with different aspects of the experimental setup. It is known that sharpness parameter characterizes precision of the measurements and decreasing sharpness parameter of the measurements reduces the possibility of probing quantum features like quantum mechanical (QM) violation of local-realism (LR) or macro-realism (MR). Here we investigate the effect of biasedness together with that of sharpness of measurements and find a trade-off between those two parameters in the context of probing QM violations of LR and MR. Interestingly, we also find that the above mentioned trade-off is more robust in the latter case.

The Case for Using Blunt-Tipped Lightning Rods as Strike Receptors.

NASA Astrophysics Data System (ADS)

Moore, C. B.; Aulich, G. D.; Rison, William

2003-07-01

Conventional lightning rods used in the United States have sharp tips, a practice derived from Benjamin Franklin's discovery of a means to obtain protection from lightning. However, the virtue of sharp tips for strike reception has never been established. An examination of the relevant physics shows that very strong electric fields are required above the tips of rods in order that they function as strike receptors but that the gradients of the field strength over sharp-tipped rods are so great that, at distances of a few millimeters, the local fields are often too weak for the development of upward-going streamers. In field tests, rods with rounded tips have been found to be better strike receptors than were nearby sharp-tipped rods.

Practitioner involvement in clinical evaluation.

PubMed

Penka, C E; Kirk, S A

1991-11-01

Contrary to popular belief, social workers are evaluating their practice, but what they do falls short of the use of quantitative procedures that researchers have promoted. Data obtained from a survey of social workers drawn from the National Association of Social Workers national membership list suggest that the gap between practitioners and clinical researchers may stem in part from different mindsets as well as from actual differences in the commitment to the importance of clinical evaluation. Moreover, in the minds of practitioners there appears to be a sharp distinction between formal single-subject design studies and the general evaluative tasks in which they routinely engage.

Freedom of Information Act: scalpel or just a sharp knife?

PubMed

Hammond, Simon P; Cross, Jane L; Poland, Fiona M; Patel, Martyn; Penhale, Bridget; Smith, Toby O; Fox, Chris

2017-01-01

The concluding statement of the Burns Commission, established to evaluate whether changes are needed to the Freedom of Information Act (FOIA), ruled no major legislative changes were required. As such Freedom of Information (FOI) legislation still enables anyone to obtain information from public authorities. In this brief report article we explore arguments regarding FOI as an instrument for healthcare research using an international research programme as a case study. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Ant colony algorithm for clustering in portfolio optimization

NASA Astrophysics Data System (ADS)

Subekti, R.; Sari, E. R.; Kusumawati, R.

2018-03-01

This research aims to describe portfolio optimization using clustering methods with ant colony approach. Two stock portfolios of LQ45 Indonesia is proposed based on the cluster results obtained from ant colony optimization (ACO). The first portfolio consists of assets with ant colony displacement opportunities beyond the defined probability limits of the researcher, where the weight of each asset is determined by mean-variance method. The second portfolio consists of two assets with the assumption that each asset is a cluster formed from ACO. The first portfolio has a better performance compared to the second portfolio seen from the Sharpe index.

Pollution and Infant Health.

PubMed

Currie, Janet

2013-12-01

In this article, I review recent research showing that even relatively low levels of pollution can affect infants' health. This research attempts to go beyond documenting correlations by using sharp changes in pollution levels, carefully selecting control groups (including unexposed siblings as controls for exposed children), and considering behavioral responses to pollution such as maternal mobility. Poor and minority children are more likely to be affected and differential exposure could be responsible for some of the observed group-level differences in health at birth. Policymakers concerned about the roots of inequality should consider the role played by environmental exposures of pregnant mothers.

Don Sharp Home Improvements Information Sheet

EPA Pesticide Factsheets

Don Sharp Home Improvements (the Company) is located in Bartlett, Tennessee. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Memphis, Tennessee.

Magnified Effects of Changes in NIH Research Funding Levels.

PubMed

Larson, Richard C; Ghaffarzadegan, Navid; Diaz, Mauricio Gomez

2012-12-01

What happens within the university-based research enterprise when a federal funding agency abruptly changes research grant funding levels, up or down? We use simple difference equation models to show that an apparently modest increase or decrease in funding levels can have dramatic effects on researchers, graduate students, postdocs, and the overall research enterprise. The amplified effect is due to grants lasting for an extended period, thereby requiring the majority of funds available in one year to pay for grants awarded in previous years. We demonstrate the effect in various ways, using National Institutes of Health data for two situations: the historical doubling of research funding from 1998 to 2003 and the possible effects of "sequestration" in January 2013. We posit human responses to such sharp movements in funding levels and offer suggestions for amelioration.

Research Assistants Caught in Limbo: Considering Their Role in Quantitative, Longitudinal Research with Vulnerable Populations.

PubMed

Zerger, Suzanne; Pridham, Katherine Francombe; Plenert, Erin; Newberry, Caitlin; Whisler, Adam; Fernando, Indira; Ahmed, Naveed

2015-11-01

Research assistants (RAs) play a variety of roles that are critical in making research happen and in determining its quality and effectiveness. Yet their locus of power in the production of knowledge stands in sharp contrast to their relative powerlessness in the hierarchical research organization. This article explores the experiences of RAs engaged in a randomized controlled longitudinal field trial of a Housing First intervention for individuals experiencing homelessness and mental illness in Toronto. They encountered several unexpected effects of navigating the power ascribed to them by both study participants and community service providers. This study underscores the importance of acknowledging that RAs are the face of the research study in the field, and of better understanding implications associated with that fact, especially when marginalized populations and their providers are involved.

Magnified Effects of Changes in NIH Research Funding Levels

PubMed Central

Larson, Richard C.; Ghaffarzadegan, Navid; Diaz, Mauricio Gomez

2013-01-01

What happens within the university-based research enterprise when a federal funding agency abruptly changes research grant funding levels, up or down? We use simple difference equation models to show that an apparently modest increase or decrease in funding levels can have dramatic effects on researchers, graduate students, postdocs, and the overall research enterprise. The amplified effect is due to grants lasting for an extended period, thereby requiring the majority of funds available in one year to pay for grants awarded in previous years. We demonstrate the effect in various ways, using National Institutes of Health data for two situations: the historical doubling of research funding from 1998 to 2003 and the possible effects of “sequestration” in January 2013. We posit human responses to such sharp movements in funding levels and offer suggestions for amelioration. PMID:24489978

Classification of Global Urban Centers Using ASTER Data: Preliminary Results From the Urban Environmental Monitoring Program

NASA Astrophysics Data System (ADS)

Stefanov, W. L.; Stefanov, W. L.; Christensen, P. R.

2001-05-01

Land cover and land use changes associated with urbanization are important drivers of global ecologic and climatic change. Quantification and monitoring of these changes are part of the primary mission of the ASTER instrument, and comprise the fundamental research objective of the Urban Environmental Monitoring (UEM) Program. The UEM program will acquire day/night, visible through thermal infrared ASTER data twice per year for 100 global urban centers over the duration of the mission (6 years). Data are currently available for a number of these urban centers and allow for initial comparison of global city structure using spatial variance texture analysis of the 15 m/pixel visible to near infrared ASTER bands. Variance texture analysis highlights changes in pixel edge density as recorded by sharp transitions from bright to dark pixels. In human-dominated landscapes these brightness variations correlate well with urbanized vs. natural land cover and are useful for characterizing the geographic extent and internal structure of cities. Variance texture analysis was performed on twelve urban centers (Albuquerque, Baghdad, Baltimore, Chongqing, Istanbul, Johannesburg, Lisbon, Madrid, Phoenix, Puebla, Riyadh, Vancouver) for which cloud-free daytime ASTER data are available. Image transects through each urban center produce texture profiles that correspond to urban density. These profiles can be used to classify cities into centralized (ex. Baltimore), decentralized (ex. Phoenix), or intermediate (ex. Madrid) structural types. Image texture is one of the primary data inputs (with vegetation indices and visible to thermal infrared image spectra) to a knowledge-based land cover classifier currently under development for application to ASTER UEM data as it is acquired. Collaboration with local investigators is sought to both verify the accuracy of the knowledge-based system and to develop more sophisticated classification models.

Quality Assurance and Control Considerations in Environmental Measurements and Monitoring

NASA Astrophysics Data System (ADS)

Sedlet, Jacob

1982-06-01

Quality assurance and quality control have become accepted as essential parts of all environmental surveillance, measurements, and monitoring programs, both nuclear and non-nuclear. The same principles and details apply to each. It is primarily the final measurement technique that differs. As the desire and need to measure smaller amounts of pollutants with greater accuracy has increased, it has been recognized that quality assurance and control programs are cost-effective in achieving the expected results. Quality assurance (QA) consists of all the actions necessary to provide confidence in the results. Quality control (QC) is a part of QA, and consists of those actions and activities that permit the control of the individual steps in the environmental program. The distinction between the two terms is not always clearly defined, but a sharp division is not necessary. The essential principle of QA and QC is a commitment to high quality results. The essential components of a QA and QC program are a complete, written procedures manual for all parts of the environmental program, the use of standard or validated procedures, participation in applicable interlaboratory comparison or QA programs, replicate analysis and measurement, training of personnel, and a means of auditing or checking that the QA and QC programs are properly conducted. These components are discussed below in some detail.

A model for managing sources of groundwater pollution

USGS Publications Warehouse

Gorelick, Steven M.

1982-01-01

The waste disposal capacity of a groundwater system can be maximized while maintaining water quality at specified locations by using a groundwater pollutant source management model that is based upon linear programing and numerical simulation. The decision variables of the management model are solute waste disposal rates at various facilities distributed over space. A concentration response matrix is used in the management model to describe transient solute transport and is developed using the U.S. Geological Survey solute transport simulation model. The management model was applied to a complex hypothetical groundwater system. Large-scale management models were formulated as dual linear programing problems to reduce numerical difficulties and computation time. Linear programing problems were solved using a numerically stable, available code. Optimal solutions to problems with successively longer management time horizons indicated that disposal schedules at some sites are relatively independent of the number of disposal periods. Optimal waste disposal schedules exhibited pulsing rather than constant disposal rates. Sensitivity analysis using parametric linear programing showed that a sharp reduction in total waste disposal potential occurs if disposal rates at any site are increased beyond their optimal values.

Social marketing to plan a fall prevention program for Latino construction workers.

PubMed

Menzel, Nancy N; Shrestha, Pramen P

2012-08-01

Latino construction workers experience disparities in occupational death and injury rates. The Occupational Safety and Health Administration funded a fall prevention training program at the University of Nevada, Las Vegas in response to sharp increases in fall-related accidents from 2005 to 2007. The grant's purpose was to improve fall protection for construction workers, with a focus on Latinos. This study assessed the effectiveness of social marketing for increasing fall prevention behaviors. A multi-disciplinary team used a social marketing approach to plan the program. We conducted same day class evaluations and follow-up interviews 8 weeks later. The classes met trainee needs as evidenced by class evaluations and increased safety behaviors. However, Spanish-speaking Latinos did not attend in the same proportion as their representation in the Las Vegas population. A social marketing approach to planning was helpful to customize the training to Latino worker needs. However, due to the limitations of behavior change strategies, future programs should target employers and their obligation to provide safer workplaces. Copyright © 2012 Wiley Periodicals, Inc.

Computed tomography coronary stent imaging with iterative reconstruction: a trade-off study between medium kernel and sharp kernel.

PubMed

Zhou, Qijing; Jiang, Biao; Dong, Fei; Huang, Peiyu; Liu, Hongtao; Zhang, Minming

2014-01-01

To evaluate the improvement of iterative reconstruction in image space (IRIS) technique in computed tomographic (CT) coronary stent imaging with sharp kernel, and to make a trade-off analysis. Fifty-six patients with 105 stents were examined by 128-slice dual-source CT coronary angiography (CTCA). Images were reconstructed using standard filtered back projection (FBP) and IRIS with both medium kernel and sharp kernel applied. Image noise and the stent diameter were investigated. Image noise was measured both in background vessel and in-stent lumen as objective image evaluation. Image noise score and stent score were performed as subjective image evaluation. The CTCA images reconstructed with IRIS were associated with significant noise reduction compared to that of CTCA images reconstructed using FBP technique in both of background vessel and in-stent lumen (the background noise decreased by approximately 25.4% ± 8.2% in medium kernel (P

Langley Full-scale-tunnel Investigation of Maximum Lift and Stability Characteristics of an Airplane Having Approximately Triangular Plan Form (DM-1 Glider)

NASA Technical Reports Server (NTRS)

Lovell, J Calvin; Wilson, Herbert A JR

1947-01-01

An investigation of the DM-1 Glider, which had approximately triangular plan form, an aspect ratio of 1.8 and a 60 degree sweptback leading edge, has been conducted in the Langley full-scale tunnel. The investigation consisted of the determination of the separate effects of the following modifications made to the glider on its maximum lift and stability characteristics: (a) installation of sharp leading edges over the inboard semispan of the wing, (b) removal of the vertical fin, (c) sealing of the elevon control-balance slots, (d) installation of redesigned thin vertical surfaces, (e) installation of faired sharp leading edges, and (f) installation of canopy. The maximum lift coefficient of the DM-1 glider was increased from 0.61 to 1.01 by the installation of semispan sharp leading edges, and from 1.01 to 1.24 by the removal of the vertical fin and sealing of the elevon control-balance slots. The highest maximum lift coefficient (1.32) was obtained when the faired sharp leading edges and the thin vertical surfaces were attached to the glider. The original DM-1 glider was longitudinally stable. The semispan sharp leading edges shifted the neutral point forward approximately 3 percent of the root chord at moderate lift coefficients, and the glider configuration with these sharp leading edges attached was longitudinally unstable, for the assumed center-of-gravity location, at lift coefficients above 0.73. Sealing the elevon control-balance slots and installing the faired sharp leading edges, the thin vertical surfaces, and the canopy shifted the neutral point forward approximately 8 percent of the root chord.

National Dam Inspection Program. Johnson’s Pond (NDI-ID Number MD-11), Wicomico River Basin, Wicomico River, Wicomico County, Maryland. Phase I Inspection Report,

DTIC Science & Technology

1980-07-01

a mean high tide of 2.07 feet above m.s.l. and a mean low tide of 0.93 feet below mean sea level. Driven timber sheeting forming a sharp crested weir ...dam for Johnson’s Pond since its crest elevation exceeds mean high tide events. However, during record high tide events, the weir becomes submerged...comprised of a 300 foot long ogee spillway with wingwalls at the left and right abutments. According to the dam crest survey, the lowest point along the

Consumerism and wellness: rising tide, falling cost.

PubMed

Domaszewicz, Alexander

2008-01-01

Annual employer-sponsored health plan cost increases have been slowing incrementally due to slowing health care utilization--a phenomenon very likely tied to the proliferation of health management activities, wellness programs and other consumerism strategies. This article describes the sharp rise in recent years of consumer-directed health plans (CDHPs) and explains what developments must happen for genuine consumer-directed health care to realize its full potential. These developments include gathering transparent health care information, increasing consumer demand for that information and creating truly intuitive data solutions that allow consumers to easily access information in order to make better health care decisions.

A review of the Z2-FET 1T-DRAM memory: Operation mechanisms and key parameters

NASA Astrophysics Data System (ADS)

Cristoloveanu, S.; Lee, K. H.; Parihar, M. S.; El Dirani, H.; Lacord, J.; Martinie, S.; Le Royer, C.; Barbe, J.-Ch.; Mescot, X.; Fonteneau, P.; Galy, Ph.; Gamiz, F.; Navarro, C.; Cheng, B.; Duan, M.; Adamu-Lema, F.; Asenov, A.; Taur, Y.; Xu, Y.; Kim, Y.-T.; Wan, J.; Bawedin, M.

2018-05-01

The band-modulation and sharp-switching mechanisms in Z2-FET device operated as a capacitorless 1T-DRAM memory are reviewed. The main parameters that govern the memory performance are discussed based on detailed experiments and simulations. This 1T-DRAM memory does not suffer from super-coupling effect and can be integrated in sub-10 nm thick SOI films. It offers low leakage current, high current margin, long retention, low operating voltage especially for programming, and high speed. The Z2-FET is suitable for embedded memory applications.

How Financial Incentives Induce Disability Insurance Recipients to Return to Work.

PubMed

Kostol, Andreas Ravndal; Mogstad, Magne

2014-02-01

Using a local randomized experiment that arises from a sharp discontinuity in Disability Insurance (DI) policy in Norway, we provide transparent and credible identification of how financial incentives induce DI recipients to return to work. We find that many DI recipients have considerable capacity to work that can be effectively induced by providing financial work incentives. We further show that providing work incentives to DI recipients may both increase their disposable income and reduce program costs. Our findings also suggest that targeted policies may be the most effective in encouraging DI recipients to return to work.

Metallic Hydrogen

NASA Astrophysics Data System (ADS)

Silvera, Isaac; Zaghoo, Mohamed; Salamat, Ashkan

2015-03-01

Hydrogen is the simplest and most abundant element in the Universe. At high pressure it is predicted to transform to a metal with remarkable properties: room temperature superconductivity, a metastable metal at ambient conditions, and a revolutionary rocket propellant. Both theory and experiment have been challenged for almost 80 years to determine its condensed matter phase diagram, in particular the insulator-metal transition. Hydrogen is predicted to dissociate to a liquid atomic metal at multi-megabar pressures and T =0 K, or at megabar pressures and very high temperatures. Thus, its predicted phase diagram has a broad field of liquid metallic hydrogen at high pressure, with temperatures ranging from thousands of degrees to zero Kelvin. In a bench top experiment using static compression in a diamond anvil cell and pulsed laser heating, we have conducted measurements on dense hydrogen in the region of 1.1-1.7 Mbar and up to 2200 K. We observe a first-order phase transition in the liquid phase, as well as sharp changes in optical transmission and reflectivity when this phase is entered. The optical signature is that of a metal. The mapping of the phase line of this transition is in excellent agreement with recent theoretical predictions for the long-sought plasma phase transition to metallic hydrogen. Research supported by the NSF, Grant DMR-1308641, the DOE Stockpile Stewardship Academic Alliance Program, Grant DE-FG52-10NA29656, and NASA Earth and Space Science Fellowship Program, Award NNX14AP17H.

Nano Electronics on Atomically Controlled van der Waals Quantum Heterostructures

DTIC Science & Technology

2015-03-30

for the structural of the atomically sharp interface between hBN and Bi2Te3. Finally, we have developed unprecedentedly clean graphene supercoductor...crystals by MBE method. We also use transmission electron microscopy (TEM) analysis for the structural of the atomically sharp interface between hBN and...by MBE method. We also use transmission electron microscopy (TEM) analysis for the structural of the atomically sharp interface between hBN and Bi2Te3

Sharp-front wave of strong magnetic field diffusion in solid metal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao, Bo; Gu, Zhuo-wei; Kan, Ming-xian

When a strong magnetic field diffuses into a solid metal, if the metal's resistance possesses an abrupt rise at some critical temperature and the magnetic field strength is above some critical value, the magnetic field will diffuse into the metal in the form of a sharp-front wave. Formulas for the critical conditions under which a sharp-front magnetic diffusion wave emerges and a formula for the wave-front velocity are derived in this work.

Variational Implicit Solvation with Solute Molecular Mechanics: From Diffuse-Interface to Sharp-Interface Models.

PubMed

Li, Bo; Zhao, Yanxiang

2013-01-01

Central in a variational implicit-solvent description of biomolecular solvation is an effective free-energy functional of the solute atomic positions and the solute-solvent interface (i.e., the dielectric boundary). The free-energy functional couples together the solute molecular mechanical interaction energy, the solute-solvent interfacial energy, the solute-solvent van der Waals interaction energy, and the electrostatic energy. In recent years, the sharp-interface version of the variational implicit-solvent model has been developed and used for numerical computations of molecular solvation. In this work, we propose a diffuse-interface version of the variational implicit-solvent model with solute molecular mechanics. We also analyze both the sharp-interface and diffuse-interface models. We prove the existence of free-energy minimizers and obtain their bounds. We also prove the convergence of the diffuse-interface model to the sharp-interface model in the sense of Γ-convergence. We further discuss properties of sharp-interface free-energy minimizers, the boundary conditions and the coupling of the Poisson-Boltzmann equation in the diffuse-interface model, and the convergence of forces from diffuse-interface to sharp-interface descriptions. Our analysis relies on the previous works on the problem of minimizing surface areas and on our observations on the coupling between solute molecular mechanical interactions with the continuum solvent. Our studies justify rigorously the self consistency of the proposed diffuse-interface variational models of implicit solvation.

Long working hours increase the risk of sharp and needlestick injury in nurses: the need for new policy implication.

PubMed

Ilhan, Mustafa N; Durukan, Elif; Aras, Evin; Türkçüoğlu, Sertaç; Aygün, Remzi

2006-12-01

This paper reports a study to determine the sharp and needlestick injury incidence in nurses working at a university hospital and the contributing factors. Although it is generally felt that working in the healthcare sector is clean and without risk, healthcare staff and especially physicians and nurses who generally work very long hours are actually exposed to various occupational risks. Sharps and needlestick injuries are important problems for healthcare workers as they increase the risk of spread of infection. A self-administered questionnaire was completed in October 2005 by 449 of the 516 nurses working at a Turkish hospital (response rate 87.0%). The percentage of nurses experiencing a sharp or needlestick injury during their professional life was 79.7%. The incidence of exposure to sharp or needlestick injury in the last year was 68.4%. The factors increasing the rate of sharp and needlestick injury were: age 24 years and less,

Analysis of regulatory mechanisms of an insulin-inducible SHARP-2 gene by (S)-Equol.

PubMed

Haneishi, Ayumi; Takagi, Katsuhiro; Asano, Kosuke; Yamamoto, Taichi; Tanaka, Takashi; Nakamura, Soichiro; Noguchi, Tamio; Yamada, Kazuya

2012-09-01

Small compounds that activate the insulin-dependent signaling pathway have potential therapeutic applications in controlling type 2 diabetes mellitus. The rat enhancer of split- and hairy-related protein-2 (SHARP-2) is an insulin-inducible transcription factor that decreases expression of the phosphoenolpyruvate carboxykinase gene, a gluconeogenic enzyme gene. In this study, we screened for soybean isoflavones that can induce the rat SHARP-2 gene expression and analyzed their mechanism(s). Genistein and (S)-Equol, a metabolite of daidzein, induced rat SHARP-2 gene expression in H4IIE rat hepatoma cells. The (S)-Equol induction was mediated by both the phosphoinositide 3-kinase- and protein kinase C (PKC)-pathways. When a dominant negative form of atypical PKC lambda (aPKCλ) was expressed, the induction of SHARP-2 mRNA level by (S)-Equol was inhibited. In addition, Western blot analyses showed that (S)-Equol rapidly activated both aPKCλ and classical PKC alpha. Furthermore, the (S)-Equol induction was inhibited by treatment with a RNA polymerase inhibitor or a protein synthesis inhibitor. Finally, a reporter gene assay revealed that the transcriptional stimulation by (S)-Equol was mediated by nucleotide sequences located between -4687 and -4133 of the rat SHARP-2 gene. Thus, we conclude that (S)-Equol is an useful dietary supplement to control type 2 diabetes mellitus. Copyright © 2012 Elsevier Inc. All rights reserved.

Design of multiplier-less sharp transition width non-uniform filter banks using gravitational search algorithm

NASA Astrophysics Data System (ADS)

Bindiya T., S.; Elias, Elizabeth

2015-01-01

In this paper, multiplier-less near-perfect reconstruction tree-structured filter banks are proposed. Filters with sharp transition width are preferred in filter banks in order to reduce the aliasing between adjacent channels. When sharp transition width filters are designed as conventional finite impulse response filters, the order of the filters will become very high leading to increased complexity. The frequency response masking (FRM) method is known to result in linear-phase sharp transition width filters with low complexity. It is found that the proposed design method, which is based on FRM, gives better results compared to the earlier reported results, in terms of the number of multipliers when sharp transition width filter banks are needed. To further reduce the complexity and power consumption, the tree-structured filter bank is made totally multiplier-less by converting the continuous filter bank coefficients to finite precision coefficients in the signed power of two space. This may lead to performance degradation and calls for the use of a suitable optimisation technique. In this paper, gravitational search algorithm is proposed to be used in the design of the multiplier-less tree-structured uniform as well as non-uniform filter banks. This design method results in uniform and non-uniform filter banks which are simple, alias-free, linear phase and multiplier-less and have sharp transition width.

Evaluation of Candidate Millimeter Wave Sensors for Synthetic Vision

NASA Technical Reports Server (NTRS)

Alexander, Neal T.; Hudson, Brian H.; Echard, Jim D.

1994-01-01

The goal of the Synthetic Vision Technology Demonstration Program was to demonstrate and document the capabilities of current technologies to achieve safe aircraft landing, take off, and ground operation in very low visibility conditions. Two of the major thrusts of the program were (1) sensor evaluation in measured weather conditions on a tower overlooking an unused airfield and (2) flight testing of sensor and pilot performance via a prototype system. The presentation first briefly addresses the overall technology thrusts and goals of the program and provides a summary of MMW sensor tower-test and flight-test data collection efforts. Data analysis and calibration procedures for both the tower tests and flight tests are presented. The remainder of the presentation addresses the MMW sensor flight-test evaluation results, including the processing approach for determination of various performance metrics (e.g., contrast, sharpness, and variability). The variation of the very important contrast metric in adverse weather conditions is described. Design trade-off considerations for Synthetic Vision MMW sensors are presented.

Effect of individual blade control on noise radiation

NASA Technical Reports Server (NTRS)

Swanson, S. M.; Jacklin, Stephen A.; Niesl, G.; Blaas, Achim; Kube, R.

1995-01-01

In a joint research program of NASA Ames Research Center, ZF Luftfahrttechnik, the German Aerospace Research Establishment (DLR), and EUROCOPTER Deutschland, a wind tunnel test was performed to evaluate the effects of Individual Blade Control (IBC) on rotor noise. This test was conducted in the 40x80 ft wind tunnel at NASA Ames Research Center, utilizing a full scale MBB-BO 105 four-bladed rotor system. Three microphones were installed for determination of the radiated noise, two of them on a moveable traverse below the advancing blade side and one in a fixed location below the retreating side. Acoustic results are presented for flight conditions with Blade-Vortex-Interaction (BVI) noise radiation. High noise level reductions were measured for single harmonic control inputs. In addition to the single harmonic inputs, multi-harmonic inputs were evaluated by superimposing 2/rev to 6/rev harmonics. For the first time the efficiency of sharp wavelets (60 deg and 90 deg width) on acoustic noise were measured. In order to achieve an adequate wavelet shape at the blade tip, corrections were made to account for the blade torsional behavior. In parallel with the acoustic measurements, vibratory loads were measured during the BVI flight condition to correlate the effects of IBC on noise and vibrations. It is shown how noise levels and vibrations are affected by specific IBC control inputs. In addition, correlations are made between noise levels and acoustic time histories with IBC phase and amplitude variations. For one IBC input mode with high noise reducing efficiency, a sweep of the moveable microphone traverse below the advancing side shows the effect on BVI noise directivity.

Public perception of hazardousness caused by current trends of municipal solid waste management.

PubMed

Al-Khatib, Issam A; Kontogianni, Stamatia; Abu Nabaa, Hendya; Alshami, Ni'meh; Al-Sari', Majed I

2015-02-01

Municipal solid waste (MSW) piling up is becoming a serious problem in all developing countries (DC) as a result of inequitable waste collection and treatment. Citizens' collaboration is partly based on understanding their views and their active involvement in MSW planning; on the other hand the assessment of the perception of hazardousness related with MSW is considered rather important as well since the identification of the weak points of the applied MWM strategy is eased and the level of required training is determined. Researchers implemented a case study in the West Bank (WB) and Gaza Strip (GS) regions of Palestine, taking into consideration previous researches in other developing countries. They reached to safe and useful conclusions regarding the parameters which mean the greatest in the waste management field as far as DC are concerned. Lack of skilled manpower, irregular collection services, inadequate equipment used for waste collection, inadequate legal provisions, and resource constraints are additional factors that are confirmed to be challenging the waste management scenarios in all DCs today. The research takes those factors under consideration but focuses on the educational gap and the results revealed interesting trends a significant relationship between respondent's educational attainment and their awareness of hazardous waste (hazard perception); the results will indicate the measure taking required to avoid accidents occurred in those regions (burns from toxics, cuts from sharps, etc). National policy and legislation development based on the research outcomes will ensure equitable and accessible services are in place in order to move towards a healthier environment. Specialized health education and training programs on national scale are also needed to enhance awareness on hazardous waste. Copyright © 2014 Elsevier Ltd. All rights reserved.

Special Report: Iraq and the Gulf States. The Balance of Fear

DTIC Science & Technology

2007-08-01

Iraq, the Muslim Scholars Association;48 Adnan Al - Dulaymi , leader of the Iraqi Sunni bloc al -Tawafoq; and, via recorded audio, Ibrahim al -Shammari...Congressional Research Service Report for Congress, no. RL31718 (Washington, DC: CRS, March 17, 2004), 4. 30. Jeremy M . Sharp, The Al -Jazeera News Network...Snelling, former State Senator and former Lieutenant Governor, Shelburne, Vt. MeMbers ex officio Robert M . Gates, Secretary of Defense • Barry lowenkron

Finite element analysis of low speed viscous and inviscid aerodynamic flows

NASA Technical Reports Server (NTRS)

Baker, A. J.; Manhardt, P. D.

1977-01-01

A weak interaction solution algorithm was established for aerodynamic flow about an isolated airfoil. Finite element numerical methodology was applied to solution of each of differential equations governing potential flow, and viscous and turbulent boundary layer and wake flow downstream of the sharp trailing edge. The algorithm accounts for computed viscous displacement effects on the potential flow. Closure for turbulence was accomplished using both first and second order models. The COMOC finite element fluid mechanics computer program was modified to solve the identified equation systems for two dimensional flows. A numerical program was completed to determine factors affecting solution accuracy, convergence and stability for the combined potential, boundary layer, and parabolic Navier-Stokes equation systems. Good accuracy and convergence are demonstrated. Each solution is obtained within the identical finite element framework of COMOC.

MULTISHOCKED,THREE-DIMENSIONAL SUPERSONIC FLOWFIELDS WITH REAL GAS EFFECTS

NASA Technical Reports Server (NTRS)

Kutler, P.

1994-01-01

This program determines the supersonic flowfield surrounding three-dimensional wing-body configurations of a delta wing. It was designed to provide the numerical computation of three dimensional inviscid, flowfields of either perfect or real gases about supersonic or hypersonic airplanes. The governing equations in conservation law form are solved by a finite difference method using a second order noncentered algorithm between the body and the outermost shock wave, which is treated as a sharp discontinuity. Secondary shocks which form between these boundaries are captured automatically. The flowfield between the body and outermost shock is treated in a shock capturing fashion and therefore allows for the correct formation of secondary internal shocks . The program operates in batch mode, is in CDC update format, has been implemented on the CDC 7600, and requires more than 140K (octal) word locations.

HIV Transmission

MedlinePlus

... stuck with an HIV-contaminated needle or other sharp object. This is a risk mainly for health ... stuck with an HIV-contaminated needle or other sharp object. However, even this risk is small. Scientists ...

Dangers of dermatologic surgery: protect your feet.

PubMed

Barr, Jerome; Siegel, Daniel

2004-12-01

Dermatologists frequently utilize scalpels, which are reported to be to culprit in around seven percent of the 385,000 sharps-related injuries sustained by healthcare personnel a year. Injuries from sharp devices are associated with the occupational transmission of more than 20 pathogens. Dropped scalpels may penetrate unprotected lower extremity skin, and there is no published data regarding what a shoe's actual degree of protection is against the danger of falling sharps. The purpose of this study was to evaluate and determine which types of shoes will protect their wearers. Although every shoe decreased falling sharp's degree of penetration into the feet, shoes cannot be relied on to prevent injury. More than half of the shoes allowed the scalpel blade to pass through the shoes and penetrate into the meat.

Artificial intelligence for multi-mission planetary operations

NASA Technical Reports Server (NTRS)

Atkinson, David J.; Lawson, Denise L.; James, Mark L.

1990-01-01

A brief introduction is given to an automated system called the Spacecraft Health Automated Reasoning Prototype (SHARP). SHARP is designed to demonstrate automated health and status analysis for multi-mission spacecraft and ground data systems operations. The SHARP system combines conventional computer science methodologies with artificial intelligence techniques to produce an effective method for detecting and analyzing potential spacecraft and ground systems problems. The system performs real-time analysis of spacecraft and other related telemetry, and is also capable of examining data in historical context. Telecommunications link analysis of the Voyager II spacecraft is the initial focus for evaluation of the prototype in a real-time operations setting during the Voyager spacecraft encounter with Neptune in August, 1989. The preliminary results of the SHARP project and plans for future application of the technology are discussed.

Saturday Driving Restrictions Fail to Improve Air Quality in Mexico City.

PubMed

Davis, Lucas W

2017-02-02

Policymakers around the world are turning to license-plate based driving restrictions in an effort to address urban air pollution. The format differs across cities, but most programs restrict driving once or twice a week during weekdays. This paper focuses on Mexico City, home to one of the oldest and best-known driving restriction policies. For almost two decades Mexico City's driving restrictions applied during weekdays only. This changed recently, however, when the program was expanded to include Saturdays. This paper uses hourly data from pollution monitoring stations to measure the effect of the Saturday expansion on air quality. Overall, there is little evidence that the program expansion improved air quality. Across eight major pollutants, the program expansion had virtually no discernible effect on pollution levels. These disappointing results stand in sharp contrast to estimates made before the expansion which predicted a 15%+ decrease in vehicle emissions on Saturdays. To understand why the program has been less effective than expected, the paper then turns to evidence from subway, bus, and light rail ridership, finding no evidence that the expansion was successful in getting drivers to switch to lower-emitting forms of transportation.

Saturday Driving Restrictions Fail to Improve Air Quality in Mexico City

NASA Astrophysics Data System (ADS)

Davis, Lucas W.

2017-02-01

Policymakers around the world are turning to license-plate based driving restrictions in an effort to address urban air pollution. The format differs across cities, but most programs restrict driving once or twice a week during weekdays. This paper focuses on Mexico City, home to one of the oldest and best-known driving restriction policies. For almost two decades Mexico City’s driving restrictions applied during weekdays only. This changed recently, however, when the program was expanded to include Saturdays. This paper uses hourly data from pollution monitoring stations to measure the effect of the Saturday expansion on air quality. Overall, there is little evidence that the program expansion improved air quality. Across eight major pollutants, the program expansion had virtually no discernible effect on pollution levels. These disappointing results stand in sharp contrast to estimates made before the expansion which predicted a 15%+ decrease in vehicle emissions on Saturdays. To understand why the program has been less effective than expected, the paper then turns to evidence from subway, bus, and light rail ridership, finding no evidence that the expansion was successful in getting drivers to switch to lower-emitting forms of transportation.

Saturday Driving Restrictions Fail to Improve Air Quality in Mexico City

PubMed Central

Davis, Lucas W.

2017-01-01

Policymakers around the world are turning to license-plate based driving restrictions in an effort to address urban air pollution. The format differs across cities, but most programs restrict driving once or twice a week during weekdays. This paper focuses on Mexico City, home to one of the oldest and best-known driving restriction policies. For almost two decades Mexico City’s driving restrictions applied during weekdays only. This changed recently, however, when the program was expanded to include Saturdays. This paper uses hourly data from pollution monitoring stations to measure the effect of the Saturday expansion on air quality. Overall, there is little evidence that the program expansion improved air quality. Across eight major pollutants, the program expansion had virtually no discernible effect on pollution levels. These disappointing results stand in sharp contrast to estimates made before the expansion which predicted a 15%+ decrease in vehicle emissions on Saturdays. To understand why the program has been less effective than expected, the paper then turns to evidence from subway, bus, and light rail ridership, finding no evidence that the expansion was successful in getting drivers to switch to lower-emitting forms of transportation. PMID:28151487

Adding A Spending Metric To Medicare's Value-Based Purchasing Program Rewarded Low-Quality Hospitals.

PubMed

Das, Anup; Norton, Edward C; Miller, David C; Ryan, Andrew M; Birkmeyer, John D; Chen, Lena M

2016-05-01

In fiscal year 2015 the Centers for Medicare and Medicaid Services expanded its Hospital Value-Based Purchasing program by rewarding or penalizing hospitals for their performance on both spending and quality. This represented a sharp departure from the program's original efforts to incentivize hospitals for quality alone. How this change redistributed hospital bonuses and penalties was unknown. Using data from 2,679 US hospitals that participated in the program in fiscal years 2014 and 2015, we found that the new emphasis on spending rewarded not only low-spending hospitals but some low-quality hospitals as well. Thirty-eight percent of low-spending hospitals received bonuses in fiscal year 2014, compared to 100 percent in fiscal year 2015. However, low-quality hospitals also began to receive bonuses (0 percent in fiscal year 2014 compared to 17 percent in 2015). All high-quality hospitals received bonuses in both years. The Centers for Medicare and Medicaid Services should consider incorporating a minimum quality threshold into the Hospital Value-Based Purchasing program to avoid rewarding low-quality, low-spending hospitals. Project HOPE—The People-to-People Health Foundation, Inc.

The Effects of Aperiodic Perturbation on the Last Good Surface of a Single-Null Divertor Tokamak

NASA Astrophysics Data System (ADS)

Jordan, Joseph; Punjabi, Alkesh; Ali, Halima

2003-10-01

An area-preserving discrete mapping, called the Simple Map is used to analyze the effects of aperiodic perturbation on the last good magnetic surface of a single-null divertor tokamak. The SM was developed by Punjabi and Boozer /1/. The SM equations are modified to reflect the effect of aperiodic perturbation: Xn + 1 = Xn - (k+δ_aperiodics(n))Y_n(1-Y_n), Y_n+1 = Yn + kX_n+1 where δ_aperiodic is the amplitude of the aperiodic perturbation. The equations are coded into FORTRAN and used in conjunction with a graphing program to show the trajectories for different amplitudes of aperiodic perturbation. As the aperiodic perturbation is increased, the trajectories break from a clean curve and develop strange behavior as they approach chaos. The progression of the trajectories from a clean curve to a chaotic one is observed, and the results are presented in this paper. This project is supported by NASA SHARP and US DOE Grant Number DE-F02-02ER54673. The research was done under the mentorship of Profs. Punjabi and Ali. 1. Punjabi A., Verma A., and Boozer A., Phys. Rev. Lett, 69, 3322 (1992)

Groundwater vulnerability indices conditioned by Supervised Intelligence Committee Machine (SICM).

PubMed

Nadiri, Ata Allah; Gharekhani, Maryam; Khatibi, Rahman; Sadeghfam, Sina; Moghaddam, Asghar Asghari

2017-01-01

This research presents a Supervised Intelligent Committee Machine (SICM) model to assess groundwater vulnerability indices of an aquifer. SICM uses Artificial Neural Networks (ANN) to overarch three Artificial Intelligence (AI) models: Support Vector Machine (SVM), Neuro-Fuzzy (NF) and Gene Expression Programming (GEP). Each model uses the DRASTIC index, the acronym of 7 geological, hydrological and hydrogeological parameters, which collectively represents intrinsic (or natural) vulnerability and gives a sense of contaminants, such as nitrate-N, penetrating aquifers from the surface. These models are trained to modify or condition their DRASTIC index values by measured nitrate-N concentration. The three AI-techniques often perform similarly but have differences as well and therefore SICM exploits the situation to improve the modeled values by producing a hybrid modeling results through selecting better performing SVM, NF and GEP components. The models of the study area at Ardabil aquifer show that the vulnerability indices by the DRASTIC framework produces sharp fronts but AI models smoothen the fronts and reflect a better correlation with observed nitrate values; SICM improves on the performances of three AI models and cope well with heterogeneity and uncertain parameters. Copyright © 2016 Elsevier B.V. All rights reserved.

Final Report: Identification and Manipulation of Novel Topological Phases

DTIC Science & Technology

2016-02-09

ps at TG and then exhibits a marked change in temperature dependence below TG [Fig. 4(d)]. A sharp rise in relaxation time at TN typically signifies...description, which predicts sharp first-order MITs like in V2O3.28 Although our measurements do not rule out gaps beginning to form in microscopically...Sr2IrO4 defies a strictMott-Hubbard description.We rule out the possibility of a disorder broadened TMIT in our samples based on their sharp magnetic

Numerical Modeling of Compressible Flow and Its Control

DTIC Science & Technology

2014-03-01

surface just outbound of the fin . This impinging jet is believed to be responsible for the high surface pressure, skin friction, and heat transfer in...and fine grid simulations over predict the heat transfer by roughly 13% for this case. E. LF12 Case, Sharp Fin at 12° In the LF12 case, a sharp...Dolling, D. S., and Knight, D. D., “An Experimental/Computational Study of Heat Transfer in Sharp Fin Induced Turbulent Interactions at Mach 5,” AIAA

Cuts and puncture wounds

MedlinePlus

... pointed object such as a nail, knife, or sharp tooth. Symptoms Symptoms include: Bleeding Problems with function ... the last 10 years. Prevention Keep knives, scissors, sharp objects, firearms, and fragile items out of the ...

Analysis of methods for determining high cycle fatigue strength of a material with investigation of titanium-aluminum-vanadium gigacycle fatigue behavior

NASA Astrophysics Data System (ADS)

Pollak, Randall D.

Today, aerospace engineers still grapple with the qualitative and quantitative understanding of fatigue behavior in the design and testing of turbine-driven jet engines. The Department of Defense has taken a very active role in addressing this problem with the formation of the National High Cycle Fatigue Science & Technology Program in 1994. The primary goal of this program is to further the understanding of high cycle fatigue (HCF) behavior and develop methods in order to mitigate the negative impact of HCF on aerospace operations. This research supports this program by addressing the fatigue strength testing guidance currently provided by the DoD to engine manufacturers, with the primary goal to investigate current methods and recommend a test strategy to characterize the fatigue strength of a material at a specified number of cycles, such as the 109 design goal specified by MIL-HDBK-1783B, or range of cycles. The research utilized the benefits of numerical simulation to initially investigate the staircase method for use in fatigue strength testing. The staircase method is a commonly used fatigue strength test, but its ability to characterize fatigue strength variability is extremely suspect. A modified staircase approach was developed and shown to significantly reduce bias and scatter in estimates for fatigue strength variance. Experimental validation of this proposed test strategy was accomplished using a dual-phase Ti-6Al-4V alloy. The HCF behavior of a second material with a very different microstructure (beta annealed Ti-6Al-4V) was also investigated. The random fatigue limit (RFL) model, a recently developed analysis tool, was investigated to characterize stress-life behavior but found to have difficulty representing fatigue life curves with sharp transitions. Two alternative models (bilinear and hyperbolic) were developed based on maximum likelihood methods to better characterize the Ti-6Al-4V fatigue life behavior. These models provided a good fit to the experimental data for the dual-phase Ti-6Al-4V and were applied to the beta annealed variant in order to estimate stress-life behavior using a small-sample approach. Based on this research, designers should be better able to make reliable estimates of fatigue strength parameters using small-sample testing.

Mount Sharp Inside Gale Crater, Mars

NASA Image and Video Library

2012-03-28

Curiosity, the big rover of NASA Mars Science Laboratory mission, will land in August 2012 near the foot of a mountain inside Gale Crater. The mission project science group is calling the mountain Mount Sharp.

10 CFR 960.5-2-7 - Transportation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... of sharp curves or steep grades and are not likely to be affected by landslides or rock slides. (v... highways and railroads such that steep grades, sharp switchbacks, rivers, lakes, landslides, rock slides...

Behold Mount Sharp!

NASA Image and Video Library

2012-08-06

This image taken by NASA Curiosity shows what lies ahead for the rover -- its main science target, informally called Mount Sharp. The rover shadow can be seen in the foreground, and the dark bands beyond are dunes.

Knowledge Base Editor (SharpKBE)

NASA Technical Reports Server (NTRS)

Tikidjian, Raffi; James, Mark; Mackey, Ryan

2007-01-01

The SharpKBE software provides a graphical user interface environment for domain experts to build and manage knowledge base systems. Knowledge bases can be exported/translated to various target languages automatically, including customizable target languages.

View from west sharp perspective, foundry/propeller shop. Naval Base ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View from west sharp perspective, foundry/propeller shop. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Foundry-Propeller Shop, North of Porter Avenue, west of Third Street West, Philadelphia, Philadelphia County, PA

The Heights of Mount Sharp

NASA Image and Video Library

2012-08-20

With the addition of four high-resolution Navigation Camera, or Navcam, images, taken on Aug. 18 Sol 12, Curiosity 360-degree landing-site panorama now includes the highest point on Mount Sharp visible from the rover.

American Association for Pediatric Ophthalmology and Strabismus

MedlinePlus

... to the emergency room or ophthalmologist. If a sharp object has penetrated the eye (like a fish ... room as soon as possible. Other blunt or sharp injuries should be examined by an ophthalmologist, since ...

Sharps injuries in UK health care: a review of injury rates, viral transmission and potential efficacy of safety devices.

PubMed

Elder, Alexander; Paterson, Caron

2006-12-01

To review the literature on sharps injuries and occupational bloodborne virus transmission in health care in the UK and the worldwide evidence for injury prevention of sharps safety devices. Literature review by online database and Internet resource search. Twenty-four relevant publications were identified regarding UK reported sharps injury rates. UK studies showed as much as a 10-fold difference between injuries reported through standard reporting systems (0.78-5.15 per 100 person-years) and rates estimated from retrospective questionnaires of clinical populations (30-284 per 100 person-years). National surveillance data from England, Wales and Northern Ireland gives a rate of 1.43 known hepatitis C virus or human immunodeficiency virus (HIV) transmissions to health care workers per annum. When extrapolated, this suggests an approximate rate of 0.009 such viral transmissions per 1000 hospital beds per annum. Risk of infection from sources with no risk factors is extremely small (less than one in one million for HIV transmission based on Scottish data). Thirty-one studies on the efficacy of sharps safety devices showed evidence of a reduction in injuries, with the greatest reductions achieved by blunt suture needles and safety cannulae. Although injuries remain common, confirmed viral transmission in the UK has been relatively rare. The degree of under-reporting of sharps injuries may be as much as 10-fold. Safety-engineered devices are likely to be effective at injury reduction.

Splitting hairs: differentiating between entomological activity, taphonomy, and sharp force trauma on hair.

PubMed

Mazzarelli, Debora; Vanin, Stefano; Gibelli, Daniele; Maistrello, Lara; Porta, Davide; Rizzi, Agostino; Cattaneo, Cristina

2015-03-01

The analysis of hair can provide useful information for the correct evaluation of forensic cases, but studies of trauma on hair are extremely rare. Hair may present lesions caused by traumatic events or by animals: in fact, signs of sharp force weapons on hair may provide important information for the reconstruction of the manner of death, and, for example, may suggest fetishist practice. This study stemmed from a judicial case where it was fundamental to distinguish between sharp force lesions and insect activity on hair. In order to highlight differences between sharp force lesions and insect feeding activity, different experiments were performed with high power microscopy: hair samples were subjected to several lesions by blunt and sharp force trauma; then samples were used as pabulum for two taxa of insects: the common clothes moth (Tineola bisselliella Lepidoptera, Tineidae) and the carpet beetle (Anthrenus sp., Coleoptera, Dermestidae). Hairs were examined from a macroscopic and microscopic point of view by stereomicroscopy and scanning electron microscopy (SEM): the morphological characteristics of the lesions obtained from the different experimental samples were compared. Results show that sharp force trauma produces lesions with regular edges, whereas insects leave concave lesions caused by their "gnawing" activity. These two types of lesions are easily distinguishable from breaking and tearing using SEM. This study demonstrates that insect activity leaves very specific indications on hair and sheds some light on different hair lesions that may be found in forensic cases.

What's in a Name? Sound Symbolism and Gender in First Names.

PubMed

Sidhu, David M; Pexman, Penny M

2015-01-01

Although the arbitrariness of language has been considered one of its defining features, studies have demonstrated that certain phonemes tend to be associated with certain kinds of meaning. A well-known example is the Bouba/Kiki effect, in which nonwords like bouba are associated with round shapes while nonwords like kiki are associated with sharp shapes. These sound symbolic associations have thus far been limited to nonwords. Here we tested whether or not the Bouba/Kiki effect extends to existing lexical stimuli; in particular, real first names. We found that the roundness/sharpness of the phonemes in first names impacted whether the names were associated with round or sharp shapes in the form of character silhouettes (Experiments 1a and 1b). We also observed an association between femaleness and round shapes, and maleness and sharp shapes. We next investigated whether this association would extend to the features of language and found the proportion of round-sounding phonemes was related to name gender (Analysis of Category Norms). Finally, we investigated whether sound symbolic associations for first names would be observed for other abstract properties; in particular, personality traits (Experiment 2). We found that adjectives previously judged to be either descriptive of a figuratively 'round' or a 'sharp' personality were associated with names containing either round- or sharp-sounding phonemes, respectively. These results demonstrate that sound symbolic associations extend to existing lexical stimuli, providing a new example of non-arbitrary mappings between form and meaning.

Taxonomic revision of Afrotropical Laccophilus Leach, 1815 (Coleoptera, Dytiscidae)

PubMed Central

Biström, Olof; Nilsson, Anders N.; Bergsten, Johannes

2015-01-01

Abstract The African species of the genus Laccophilus Leach, 1815, are revised, on the basis of study of adult specimens. In all, 105 species are now recognized. A phenetic character-analysis was undertaken, which resulted in a split of the genus into 17 species groups. Diagnoses and a description of each species are given together with keys for identification of species groups and species. We also provide habitus photos, illustration of male genitalia and distribution maps for all species. New species are described as follows: Laccophilus grossus sp. n. (Angola, Namibia), Laccophilus rocchii sp. n. (Tanzania, Namibia, Botswana, Mozambique), Laccophilus ferrugo sp. n. (Mozambique), Laccophilus furthi sp. n. (Madagascar), Laccophilus isamberti sp. n. (Madagascar), Laccophilus inobservatus sp. n. (Gambia, Senegal, Mali, Niger, Sudan, Chad, Ethiopia, Burkina Faso, Ivory Coast, Ghana, Nigeria, Cameroon, Zaire and Asia: Yemen), Laccophilus cryptos sp. n. (Zaire, Mozambique, Zimbabwe, Namibia, Botswana, South Africa), Laccophilus enigmaticus sp. n. (Nigeria, Sudan), Laccophilus bellus sp. n. (Benin, Nigeria), Laccophilus guentheri sp. n. (Guinea, Ghana), Laccophilus guineensis sp. n. (Guinea), Laccophilus decorosus sp. n. (Uganda), Laccophilus empheres sp. n. (Kenya), Laccophilus inconstans sp. n. (Guinea, Ivory Coast, Ghana, Nigeria, Cameroon), Laccophilus brancuccii sp. n. (Central African Republic), Laccophilus incomptus sp. n. (Cameroon), Laccophilus australis sp. n. (Tanzania, South Africa), Laccophilus minimus sp. n. (Namibia), Laccophilus eboris sp. n. (Ivory Coast), Laccophilus insularum sp. n. (Madagascar), Laccophilus occidentalis sp. n. (Gambia, Senegal, Mali, Guinea, Sierra Leone, Ivory Coast, Ghana, Benin, Nigeria, Central African Republic, Zaire) and Laccophilus transversovittatus sp. n. (Madagascar). Laccophilus restrictus Sharp, 1882, is restored as good species; not junior synonym of Laccophilus pictipennis Sharp, 1882. New synonyms are established as follows: Laccophilus continentalis Gschwendtner, 1935 = Laccophilus perplexus Omer-Cooper, 1970, syn. n., Laccophilus taeniolatus Régimbart, 1889 = Laccophilus congener Omer-Cooper, 1957, syn. n., Laccophilus adspersus Boheman, 1848 = Laccophilus vitshumbii Guignot, 1959, syn. n. = Laccophilus adspersus nigeriensis Omer-Cooper, 1970, syn. n. = Laccophilus adspersus sudanensis Omer-Cooper, 1970, syn. n., Laccophilus modestus Régimbart, 1895 = Laccophilus espanyoli Hernando, 1990, syn. n., Laccophilus flaveolus Régimbart, 1906 = Laccophilus pampinatus Guignot, 1941, syn. n., Laccophilus trilineola Régimbart, 1889 = Laccophilus simulator Omer-Cooper, 1958, syn. n., Laccophilus mediocris Guignot, 1952 = Laccophilus meii Rocchi, 2000, syn. n., Laccophilus epinephes Guignot, 1955 = Laccophilus castaneus Guignot, 1956, syn. n., Laccophilus saegeri Guignot, 1958 = Laccophilus comoensis Pederzani & Reintjes, 2002, syn. n., Laccophilus restrictus Sharp, 1882 = Laccophilus evanescens Régimbart, 1895, syn. n., Laccophilus incrassatus Gschwendtner, 1933 = Laccophilus virgatus Guignot, 1953, syn. n., Laccophilus cyclopis Sharp, 1882 = Laccophilus shephardi Omer-Cooper, 1965, syn. n., Laccophilus burgeoni Gschwendtner, 1930 = Laccophilus wittei Guignot, 1952, syn. n., Laccophilus secundus Régimbart, 1895 = Laccophilus torquatus Guignot, 1956, syn. n., Laccophilus desintegratus Régimbart, 1895 = Laccophilus sanguinosus Régimbart, 1895, syn. n. and Laccophilus flavopictus Régimbart, 1889 = Laccophilus bergeri Guignot, 1953, syn. n. = Laccophilus segmentatus Omer-Cooper, 1957, syn. n. Lectotypes are designated for the following taxa: Laccophilus productus Régimbart, 1906, Laccophilus ruficollis Zimmermann, 1919, Laccophilus sordidus Sharp, 1882, Laccophilus alluaudi Régimbart, 1899, Laccophilus pictipennis Sharp, 1882, Laccophilus wehnckei Sharp, 1882, Laccophilus continentalis Gschwendtner, 1935, Laccophilus simplicistriatus Gschwendtner, 1932, Laccophilus complicatus Sharp, 1882, Laccophilus rivulosus Klug, 1833, Laccophilus ampliatus Régimbart, 1895, Laccophilus pilitarsis Régimbart, 1906, Laccophilus adspersus Boheman, 1848, Laccophilus livens Régimbart, 1895, Laccophilus modestus Régimbart, 1895, Laccophilus nodieri Régimbart, 1895, Laccophilus flaveolus Régimbart, 1906, Laccophilus pallescens Régimbart, 1903, Laccophilus restrictus Sharp, 1882, Laccophilus vermiculosus Gerstaecker, 1867, Laccophilus mocquerysi Régimbart, 1895, Laccophilus bizonatus Régimbart, 1895, Laccophilus tschoffeni Régimbart, 1895, Laccophilus persimilis Régimbart, 1895, Laccophilus poecilus Klug, 1834, Laccophilus lateralis Sharp, 1882, Laccophilus lateralis var. polygrammus Régimbart, 1903, Laccophilus cyclopis Sharp, 1882, Laccophilus shephardi Omer-Cooper, 1965, Laccophilus conjunctus Guignot, 1950, Laccophilus grammicus Sharp, 1882, Laccophilus flavoscriptus Régimbart, 1895, Laccophilus flavosignatus Régimbart, 1895, Laccophilus brevicollis Sharp, 1882, Laccophilus secundus Régimbart, Laccophilus desintegratus Régimbart, 1895, Laccophilus gutticollis Régimbart, 1895, Laccophilus luctuosus Sharp, 1882 and Laccophilus inornatus Zimmermann, 1926. Laccophilus remex Guignot, 1952, comprises a species complex with uncertain taxonomic delimitation; the complex includes Laccophilus concisus Guignot, 1953, Laccophilus turneri Omer-Cooper, 1957 and Laccophilus praeteritus Omer-Cooper, 1957, as tentative synonyms of Laccophilus remex Guignot, 1952. PMID:26798285

New simple evaluation method of the monosyllable /sa/ using a psychoacoustic system in maxillectomy patients.

PubMed

Chowdhury, Nafees Uddin; Otomaru, Takafumi; Murase, Mai; Inohara, Ken; Hattori, Mariko; Sumita, Yuka I; Taniguchi, Hisashi

2011-01-01

An objective assessment of speech would benefit the prosthetic rehabilitation of maxillectomy patients. This study aimed to establish a simple, objective evaluation of monosyllable /sa/ utterances in maxillectomy patients by using a psychoacoustic system typically used in industry. This study comprised two experiments. Experiment 1 involved analysis of the psychoacoustic parameters (loudness, sharpness and roughness) in monosyllable /sa/ utterances by 18 healthy subjects (9 males, 9 females). The utterances were recorded in a sound-treated room. The coefficient of variation (CV) for each parameter was compared to identify the most suitable parameter for objective evaluation of speech. Experiment 2 involved analysis of /sa/ utterances by 18 maxillectomy patients (9 males, 9 females) with and without prosthesis, and comparisons of the psychoacoustic data between the healthy subjects and maxillectomy patients without prosthesis, between the maxillectomy patients with and without prosthesis, and between the healthy subjects and maxillectomy patients with prosthesis. The CV for sharpness was the lowest among the three psychoacoustic parameters in both the healthy males and females. There were significant differences in the sharpness of /sa/ between the healthy subjects and the maxillectomy patients without prosthesis (but not with prosthesis), and between the maxillectomy patients with and without prosthesis. We found that the psychoacoustic parameters typically adopted in industrial research could also be applied to evaluate the psychoacoustics of the monosyllable /sa/ utterance, and distinguished the monosyllable /sa/ in maxillectomy patients with an obturator from that without an obturator using the system. Copyright © 2010 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

Joint Center for Operational Analysis Quarterly Bulletin. Volume 7, Issue 3, June 2005

DTIC Science & Technology

2005-06-01

sharp salute. Then, between us, coffins draped in the Romanian colors and holding the remains of Romanian soldiers killed in action slowly passed by... Armoured Division integrated with the US 1st Marine Expeditionary Force was helped by similar doctrine, and the Royal Air Force’s (RAF) ability to...various situations. While research continues in this focus area across the coalition, there are some findings to convey. 3.3.1 Armour in the Urban

HYPERSONIC BOUNDARY LAYER TRANSITION EXPERIMENTS- HYPERSONIC INTERNATIONAL FLIGHT RESEARCH EXPERIMENTATION 5 (HIFIRE-5) AND CIRCULAR CONE

DTIC Science & Technology

2016-10-01

each case in the present study , and two examples for a sharp and blunt case are presented in Figure 3-4. While the freestream unit Reynolds number is...conditions for shot 2821 in 50% CO2, 50% air by mass. For further details on this condition see Jewell and Shepherd...Several advances were made under this task during FY16. Quantitative simultaneous infrared thermography and fluctuating pressure measurements on the

Cutting moments and grip forces in meat cutting operations and the effect of knife sharpness.

PubMed

McGorry, Raymond W; Dowd, Peter C; Dempsey, Patrick G

2003-07-01

The force exposure associated with meat cutting operations and the effect of knife sharpness on performance and productivity have not been well documented. Specialized hardware was used to measure grip force and reactive moments with 15 professional meat cutters performing lamb shoulder boning, beef rib trimming and beef loin trim operations in a field study conducted in two meat packing plants. A system for measuring relative blade sharpness was developed for this study. Mean and peak cutting moments observed for the meat cutting operations, averaged across subjects were 4.7 and 17.2 Nm for the shoulder boning, 3.5 and 12.9 Nm for the rib trim, and 2.3 and 10.6 Nm for the loin trim, respectively. Expressed as percent of MVC, mean grip forces of 28.3% and peak grip forces of 72.6% were observed overall. Blade sharpness was found to effect grip forces, cutting moments and cutting time, with sharper blades requiring statistically significantly lower peak and mean cutting moments, and grip forces than dull knives. Efforts aimed at providing and maintaining sharp blades could have a significant impact on force exposure.

White House Budget Proposal Favorable Overall for Federal Science Agencies

NASA Astrophysics Data System (ADS)

Showstack, Randy

2012-02-01

President Barack Obama's proposed federal budget of 3.8 trillion for fiscal year (FY) 2013, released on 13 February, provides an overall favorable funding picture for federal science agencies in a tight economic environment. However, there are also a number of proposed decreases, including a sharp cut to NASA's Planetary Science account. Overall, the budget proposal includes 140.8 billion for the federal investment in research and development, a 1.4% increase above the FY 2012 enacted level. Funding for federal basic and applied research would be 64 billion, 3.3% above FY 2012 enacted levels. Funding for defense research and development (R&D) would decrease to 75.9 billion, a drop of 1.5%; nondefense R&D would increase 5% to $64.9 billion.

A rare case of a sharp foreign body on the vocal cord.

PubMed

Nor Hisyam, C I; Misron, K; Mohamad, I

2017-01-01

A foreign body (FB) in the upper aerodigestive tract is a common clinical problem that presents as as acute emergency. Sharp FB, such as fish bone or chicken bone, commonly lodges in the tonsil, base of tongue, vallecula or pyriform fossa. Dislodgement of a FB into the laryngopharynx is very rare and specifically onto the vocal cord is extremely uncommon. This case report illustrates a rare case of a sharp FB that was dislodged into the airway and stuck on to the right vocal cord, which was removed under local anaesthesia.

Sharps container

NASA Technical Reports Server (NTRS)

Lee, Angelene M. (Inventor)

1992-01-01

This invention relates to a system for use in disposing of potentially hazardous items and more particularly a Sharps receptacle for used hypodermic needles and the like. A Sharps container is constructed from lightweight alodined nonmagnetic metal material with a cup member having an elongated tapered shape and length greater than its transverse dimensions. A magnet in the cup member provides for metal retention in the container. A nonmagnetic lid member has an opening and spring biased closure flap member. The flap member is constructed from stainless steel. A Velcro patch on the container permits selective attachment at desired locations.

Automated Geometry assisted PEC for electron beam direct write nanolithography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ocola, Leonidas E.; Gosztola, David J.; Rosenmann, Daniel

Nanoscale geometry assisted proximity effect correction (NanoPEC) is demonstrated to improve PEC for nanoscale structures over standard PEC, in terms of feature sharpness for sub-100 nm structures. The method was implemented onto an existing commercially available PEC software. Plasmonic arrays of crosses were fabricated using regular PEC and NanoPEC, and optical absorbance was measured. Results confirm that the improved sharpness of the structures leads to increased sharpness in the optical absorbance spectrum features. We also demonstrated that this method of PEC is applicable to arbitrary shaped structures beyond crosses.

Hollow structure formation of intense ion beams with sharp edge in background plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Zhang-Hu; Wang, You-Nian, E-mail: ynwang@dlut.edu.cn

The transport of intense ion beams with sharp radial beam edge in plasmas has been studied with two-dimensional electromagnetic particle simulations. The initial solid beam evolves into a hollow beam due to the nonlinear sharp transverse force peak in the regions of beam edge. The magnitude and nonlinearity of this peak are enhanced as the ion beam travels further into the plasma, due to the self-consistent interactions between the beam ions and the plasma electrons. This structure formation is shown to be independent on the beam radius.

Retooling Laser Speckle Contrast Analysis Algorithm to Enhance Non-Invasive High Resolution Laser Speckle Functional Imaging of Cutaneous Microcirculation

NASA Astrophysics Data System (ADS)

Gnyawali, Surya C.; Blum, Kevin; Pal, Durba; Ghatak, Subhadip; Khanna, Savita; Roy, Sashwati; Sen, Chandan K.

2017-01-01

Cutaneous microvasculopathy complicates wound healing. Functional assessment of gated individual dermal microvessels is therefore of outstanding interest. Functional performance of laser speckle contrast imaging (LSCI) systems is compromised by motion artefacts. To address such weakness, post-processing of stacked images is reported. We report the first post-processing of binary raw data from a high-resolution LSCI camera. Sharp images of low-flowing microvessels were enabled by introducing inverse variance in conjunction with speckle contrast in Matlab-based program code. Extended moving window averaging enhanced signal-to-noise ratio. Functional quantitative study of blood flow kinetics was performed on single gated microvessels using a free hand tool. Based on detection of flow in low-flow microvessels, a new sharp contrast image was derived. Thus, this work presents the first distinct image with quantitative microperfusion data from gated human foot microvasculature. This versatile platform is applicable to study a wide range of tissue systems including fine vascular network in murine brain without craniotomy as well as that in the murine dorsal skin. Importantly, the algorithm reported herein is hardware agnostic and is capable of post-processing binary raw data from any camera source to improve the sensitivity of functional flow data above and beyond standard limits of the optical system.

Retooling Laser Speckle Contrast Analysis Algorithm to Enhance Non-Invasive High Resolution Laser Speckle Functional Imaging of Cutaneous Microcirculation

PubMed Central

Gnyawali, Surya C.; Blum, Kevin; Pal, Durba; Ghatak, Subhadip; Khanna, Savita; Roy, Sashwati; Sen, Chandan K.

2017-01-01

Cutaneous microvasculopathy complicates wound healing. Functional assessment of gated individual dermal microvessels is therefore of outstanding interest. Functional performance of laser speckle contrast imaging (LSCI) systems is compromised by motion artefacts. To address such weakness, post-processing of stacked images is reported. We report the first post-processing of binary raw data from a high-resolution LSCI camera. Sharp images of low-flowing microvessels were enabled by introducing inverse variance in conjunction with speckle contrast in Matlab-based program code. Extended moving window averaging enhanced signal-to-noise ratio. Functional quantitative study of blood flow kinetics was performed on single gated microvessels using a free hand tool. Based on detection of flow in low-flow microvessels, a new sharp contrast image was derived. Thus, this work presents the first distinct image with quantitative microperfusion data from gated human foot microvasculature. This versatile platform is applicable to study a wide range of tissue systems including fine vascular network in murine brain without craniotomy as well as that in the murine dorsal skin. Importantly, the algorithm reported herein is hardware agnostic and is capable of post-processing binary raw data from any camera source to improve the sensitivity of functional flow data above and beyond standard limits of the optical system. PMID:28106129

Heterogeneous sharpness for cross-spectral face recognition

NASA Astrophysics Data System (ADS)

Cao, Zhicheng; Schmid, Natalia A.

2017-05-01

Matching images acquired in different electromagnetic bands remains a challenging problem. An example of this type of comparison is matching active or passive infrared (IR) against a gallery of visible face images, known as cross-spectral face recognition. Among many unsolved issues is the one of quality disparity of the heterogeneous images. Images acquired in different spectral bands are of unequal image quality due to distinct imaging mechanism, standoff distances, or imaging environment, etc. To reduce the effect of quality disparity on the recognition performance, one can manipulate images to either improve the quality of poor-quality images or to degrade the high-quality images to the level of the quality of their heterogeneous counterparts. To estimate the level of discrepancy in quality of two heterogeneous images a quality metric such as image sharpness is needed. It provides a guidance in how much quality improvement or degradation is appropriate. In this work we consider sharpness as a relative measure of heterogeneous image quality. We propose a generalized definition of sharpness by first achieving image quality parity and then finding and building a relationship between the image quality of two heterogeneous images. Therefore, the new sharpness metric is named heterogeneous sharpness. Image quality parity is achieved by experimentally finding the optimal cross-spectral face recognition performance where quality of the heterogeneous images is varied using a Gaussian smoothing function with different standard deviation. This relationship is established using two models; one of them involves a regression model and the other involves a neural network. To train, test and validate the model, we use composite operators developed in our lab to extract features from heterogeneous face images and use the sharpness metric to evaluate the face image quality within each band. Images from three different spectral bands visible light, near infrared, and short-wave infrared are considered in this work. Both error of a regression model and validation error of a neural network are analyzed.

Investigation of a Major Stratigraphic Unconformity with the Curiosity Rover

NASA Astrophysics Data System (ADS)

Lewis, K. W.; Grotzinger, J. P.; Gupta, S.; Rubin, D. M.

2015-12-01

Since its departure from the plains of Aeolis Palus, the Curiosity rover has traversed through a number of new geologic units at the base of Mount Sharp in Gale crater. These have included both units inferred to comprise the lower strata of Mount Sharp itself, along with units that appear to superpose Mount Sharp. Over the last 100 sols, Curiosity has documented several occurrences of a stratigraphic contact between fine-grained mudstones of the Murray Formation, and coarser sandstones of the overlying Stimson Unit. Detailed mapping from both orbital and rover image and topographic data suggests an unconformable relationship between the two units. From orbit, inferred exposures of the unconformity span at least several tens of meters, climbing up the lowermost slopes of Mount Sharp. Although the absolute timing of the two units is poorly constrained, this unconformity between likely represents a geologically significant gap in time. Deposition of the overlying Stimson Unit is inferred to post-date the large-scale erosion of Mount Sharp, likely requiring late stage aqueous interaction in the lithification of the Stimson Unit. From the rover, stereo imaging reveals the small-scale topography preserved at the Murray-Stimson contact, and allows the determination of bedding geometries within the units. Where laminations are expressed, the basal Mount Sharp rocks exhibit planar stratification at low angles to horizontal. In contrast, the coarser-grained Stimson Unit exhibits large-scale cross stratification. Three dimensional bedding geometry within this unit indicates a predominant southward transport direction uphill towards Mount Sharp. The observation of rounded calcium sulfate clasts in the lowermost Stimson Unit, interpreted to be reworked veins from the underlying Murray formation, supports the interpretation of an erosional unconformity. Investigations at the boundary between these two distinct units present a unique opportunity to probe the long-term environmental history of the Gale crater basin.

Ethical Issues in Stem Cell Research

PubMed Central

Lo, Bernard; Parham, Lindsay

2009-01-01

Stem cell research offers great promise for understanding basic mechanisms of human development and differentiation, as well as the hope for new treatments for diseases such as diabetes, spinal cord injury, Parkinson’s disease, and myocardial infarction. However, human stem cell (hSC) research also raises sharp ethical and political controversies. The derivation of pluripotent stem cell lines from oocytes and embryos is fraught with disputes about the onset of human personhood. The reprogramming of somatic cells to produce induced pluripotent stem cells avoids the ethical problems specific to embryonic stem cell research. In any hSC research, however, difficult dilemmas arise regarding sensitive downstream research, consent to donate materials for hSC research, early clinical trials of hSC therapies, and oversight of hSC research. These ethical and policy issues need to be discussed along with scientific challenges to ensure that stem cell research is carried out in an ethically appropriate manner. This article provides a critical analysis of these issues and how they are addressed in current policies. PMID:19366754

Grand Canyon Similar to Mount Sharp

NASA Image and Video Library

2012-08-27

Before NASA Curiosity rover landed on Mars, the strata exposed in Mount Sharp were compared to those in the Grand Canyon of the western United States, shown here. Scientists are surprised by just how close the similarities are.

Confidence Hills -- The First Mount Sharp Drilling Site

NASA Image and Video Library

2014-11-04

This image shows the first holes drilled by NASA Mars rover Curiosity at Mount Sharp. The loose material near the drill holes is drill tailings and an accumulation of dust that slid down the rock during drilling.

Needles and Other Sharps (Safe Disposal Outside of Health Care Settings)

MedlinePlus

... sharps containers are generally available through pharmacies, medical supply companies, health care providers and online. These containers are made of puncture-resistant plastic with leak-resistant sides and bottom. They also have a ...

Mount Sharp Panorama in Raw Colors

NASA Image and Video Library

2013-03-15

This mosaic of images from the Mastcam onboard NASA Mars rover Curiosity shows Mount Sharp in raw color. Raw color shows the scene colors as they would look in a typical smart-phone camera photo, before any adjustment.

Best Way to Get Rid of Used Needles and Other Sharps

MedlinePlus

... other options are not available. If traveling by plane, check the Transportation Security Administration (TSA) website for ... be thrown away in the common trash. Additional Consumer Information How to Get Rid of a Sharps ...

First Sampling Hole in Mount Sharp

NASA Image and Video Library

2014-09-25

This image from the Mars Hand Lens Imager MAHLI camera on NASA Curiosity Mars rover shows the first sample-collection hole drilled in Mount Sharp, the layered mountain that is the science destination of the rover extended mission.

Microfabricated instruments and methods to treat recurrent corneal erosions

DOEpatents

Britton, Jr., Charles L.; D'urso, Brian R.; Chaum, Edward; Simpson, John T.; Baba, Justin S.; Ericson, M. Nance; Warmack, Robert J.

2015-06-02

In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.

Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate.

PubMed

Kudlacek, Jan; Chvojka, Jan; Posusta, Antonin; Kovacova, Lubica; Hong, Seung Bong; Weiss, Shennan; Volna, Kamila; Marusic, Petr; Otahal, Jakub; Jiruska, Premysl

2017-01-01

Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it is well documented that pathological HFOs are suppressed by antiepileptic drugs (AEDs), the effect of AEDs on normal HFOs is not well known. In this experimental study, we have explored whether physiological HFOs (sharp-wave ripples) of hippocampal origin respond to AED treatment. The results show that application of a single dose of levetiracetam or lacosamide does not reduce the rate of sharp-wave ripples. In addition, it seems that these new generation drugs do not negatively affect the cellular and network mechanisms involved in sharp-wave ripple generation, which may provide a plausible explanation for the absence of significant negative effects on cognitive functions of these drugs, particularly on memory.

Microfabricated instruments and methods to treat recurrent corneal erosion

DOEpatents

Britton, Charles L; D& #x27; Urso, Brian R; Chaum, Edward; Simpson, John T; Baba, Justin S; Ericson, M. Nance; Warmack, Robert J

2013-11-26

In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.

Measurements of lightning rod responses to nearby strikes

NASA Astrophysics Data System (ADS)

Moore, C. B.; Aulich, G. D.; Rison, W.

2000-05-01

Following Benjamin Franklin's invention of the lightning rod, based on his discovery that electrified objects could be discharged by approaching them with a metal needle in hand, conventional lightning rods in the U.S. have had sharp tips. In recent years, the role of the sharp tip in causing a lightning rod to act as a strike receptor has been questioned leading to experiments in which pairs of various sharp-tipped and blunt rods have been exposed beneath thunderclouds to determine the better strike receptor. After seven years of tests, none of the sharp Franklin rods or of the so-called “early streamer emitters” has been struck, but 12 blunt rods with tip diameters ranging from 12.7 mm to 25.4 mm have taken strikes. Our field experiments and our analyses indicate that the strike-reception probabilities of Franklin's rods are greatly increased when their tips are made moderately blunt.

The ISR Asymmetrical Capacitor Thruster: Experimental Results and Improved Designs

NASA Technical Reports Server (NTRS)

Canning, Francis X.; Cole, John; Campbell, Jonathan; Winet, Edwin

2004-01-01

A variety of Asymmetrical Capacitor Thrusters has been built and tested at the Institute for Scientific Research (ISR). The thrust produced for various voltages has been measured, along with the current flowing, both between the plates and to ground through the air (or other gas). VHF radiation due to Trichel pulses has been measured and correlated over short time scales to the current flowing through the capacitor. A series of designs were tested, which were increasingly efficient. Sharp features on the leading capacitor surface (e.g., a disk) were found to increase the thrust. Surprisingly, combining that with sharp wires on the trailing edge of the device produced the largest thrust. Tests were performed for both polarizations of the applied voltage, and for grounding one or the other capacitor plate. In general (but not always) it was found that the direction of the thrust depended on the asymmetry of the capacitor rather than on the polarization of the voltage. While no force was measured in a vacuum, some suggested design changes are given for operation in reduced pressures.

Characterization, modeling and simulation of fused deposition modeling fabricated part surfaces

NASA Astrophysics Data System (ADS)

Taufik, Mohammad; Jain, Prashant K.

2017-12-01

Surface roughness is generally used for characterization, modeling and simulation of fused deposition modeling (FDM) fabricated part surfaces. But the average surface roughness is not able to provide the insight of surface characteristics with sharp peaks and deep valleys. It deals in the average sense for all types of surfaces, including FDM fabricated surfaces with distinct surface profile features. The present research work shows that kurtosis and skewness can be used for characterization, modeling and simulation of FDM surfaces because these roughness parameters have the ability to characterize a surface with sharp peaks and deep valleys. It can be critical in certain application areas in tribology and biomedicine, where the surface profile plays an important role. Thus, in this study along with surface roughness, skewness and kurtosis are considered to show a novel strategy to provide new transferable knowledge about FDM fabricated part surfaces. The results suggest that the surface roughness, skewness and kurtosis are significantly different at 0° and in the range (0°, 30°], [30°, 90°] of build orientation.

Far-Field Noise Induced by Bubble near Free Surface

NASA Astrophysics Data System (ADS)

Ye, Xi; Li, Jiang-tao; Liu, Jian-hua; Chen, Hai-long

2018-03-01

The motion of a bubble near the free surface is solved by the boundary element method based on the linear wave equation, and the influence of fluid compressibility on bubble dynamics is analyzed. Based on the solution of the bubble motion, the far-field radiation noise induced by the bubble is calculated using Kirchhoff moving boundary integral equation, and the influence of free surface on far-field noise is researched. As the results, the oscillation amplitude of the bubble is weakened in compressible fluid compared with that in incompressible fluid, and the free surface amplifies the effect of fluid compressibility. When the distance between the bubble and an observer is much larger than that between the bubble and free surface, the sharp wave trough of the sound pressure at the observer occurs. With the increment of the distance between the bubble and free surface, the time of the wave trough appearing is delayed and the value of the wave trough increase. When the distance between the observer and the bubble is reduced, the sharp wave trough at the observer disappears.

Interference lithographically defined and catalytically etched, large-area silicon nanocones from nanowires.

PubMed

Dawood, M K; Liew, T H; Lianto, P; Hong, M H; Tripathy, S; Thong, J T L; Choi, W K

2010-05-21

We report a simple and cost effective method for the synthesis of large-area, precisely located silicon nanocones from nanowires. The nanowires were obtained from our interference lithography and catalytic etching (IL-CE) method. We found that porous silicon was formed near the Au catalyst during the fabrication of the nanowires. The porous silicon exhibited enhanced oxidation ability when exposed to atmospheric conditions or in wet oxidation ambient. Very well located nanocones with uniform sharpness resulted when these oxidized nanowires were etched in 10% HF. Nanocones of different heights were obtained by varying the doping concentration of the silicon wafers. We believe this is a novel method of producing large-area, low cost, well defined nanocones from nanowires both in terms of the control of location and shape of the nanocones. A wide range of potential applications of the nanocone array can be found as a master copy for nanoimprinted polymer substrates for possible biomedical research; as a candidate for making sharp probes for scanning probe nanolithography; or as a building block for field emitting tips or photodetectors in electronic/optoelectronic applications.

Indian pharmaceutical patent prosecution: The changing role of Section 3(d)

PubMed Central

2018-01-01

India, like many developing countries, only recently began to grant pharmaceutical product patents. Indian patent law includes a provision, Section 3(d), which tries to limit grant of “secondary” pharmaceutical patents, i.e. patents on new forms of existing molecules and drugs. Previous research suggests the provision was rarely used against secondary applications in the years immediately following its enactment, and where it was, was redundant to other aspects of the patent law, raising concerns that 3(d) was being under-utilized by the Indian Patent Office. This paper uses a novel data source, the patent office’s first examination reports, to examine changes in the use of the provision. We find a sharp increase over time in the use of Section 3(d), including on the main claims of patent applications, though it continues to be used in conjunction with other types of objections to patentability. More surprisingly, see a sharp increase in the use of the provision against primary patent applications, contrary to its intent, raising concerns about potential over-utilization. PMID:29608604

Vocal effort modulates the motor planning of short speech structures

NASA Astrophysics Data System (ADS)

Taitz, Alan; Shalom, Diego E.; Trevisan, Marcos A.

2018-05-01

Speech requires programming the sequence of vocal gestures that produce the sounds of words. Here we explored the timing of this program by asking our participants to pronounce, as quickly as possible, a sequence of consonant-consonant-vowel (CCV) structures appearing on screen. We measured the delay between visual presentation and voice onset. In the case of plosive consonants, produced by sharp and well defined movements of the vocal tract, we found that delays are positively correlated with the duration of the transition between consonants. We then used a battery of statistical tests and mathematical vocal models to show that delays reflect the motor planning of CCVs and transitions are proxy indicators of the vocal effort needed to produce them. These results support that the effort required to produce the sequence of movements of a vocal gesture modulates the onset of the motor plan.

Justices challenge notion that prisons are exempt from ADA.

PubMed

1998-05-15

The U. S. Supreme Court questioned Paul Tufano, a Pennsylvania general council member, in a case involving whether prisoners are exempt from the Americans with Disabilities Act (ADA). The case, brought by former inmate [name removed] [name removed] against the Pennsylvania Department of Corrections, claimed that because [name removed] suffered from hypertension he was prevented from participating in a boot camp program or other programs that might have led to an earlier release. As a result, [name removed] was incarcerated a year longer than he might have been. Pennsylvania's position is that prisoners are exempt from the ADA. However, under sharp questioning by several justices, Tufano agreed that the statute does apply to prison employees and visitors. The verdict could have wide-ranging implications for prisoners with HIV. Circuit courts have been divided on the issue of what a public entity is and whether the ADA applies. A decision is expected by June 30.

Numerical Flight Mechanics Analysis Of The SHEFEX I Ascent And Re-Entry Phases

NASA Astrophysics Data System (ADS)

Bartolome Calvo, Javier; Eggers, Thino

2011-08-01

The SHarp Edge Flight EXperiment (SHEFEX) I provides a huge amount of scientific data to validate numerical tools in hypersonic flows. These data allow the direct comparison of flight measurements with the current numerical tools available at DLR. Therefore, this paper is devoted to apply a recently developed direct coupling between aerodynamics and flight dynamics to the SHEFEX I flight. In a first step, mission analyses are carried out using the trajectory optimization program REENT 6D coupled to missile DATCOM. In a second step, the direct coupling between the trajectory program and the DLR TAU code, in which the unsteady Euler equations including rigid body motion are solved, is applied to analyze some interesting parts of ascent and re-entry phases of the flight experiment. The agreement of the numerical predictions with the obtained flight data is satisfactory assuming a variable fin deflection angle.

Groundbreaking Ceremony at the NACA's Plum Brook Station

NASA Image and Video Library

1956-09-21

Addison Rothrock, the National Advisory Committee for Aeronautics’s (NACA) Assistant Director of Research, speaks at the groundbreaking ceremony for the Lewis Flight Propulsion Laboratory’s new test reactor at Plum Brook Station. This dedication event was held almost exactly one year after the NACA announced that it would build its $4.5 million nuclear reactor on 500 acres of the army’s 9000-acre Plum Brook Ordnance Works. The site was located in Sandusky, Ohio, approximately 60 miles west of the NACA Lewis laboratory in Cleveland. Lewis Director Raymond Sharp is seated to the left of Rothrock, Congressman Albert Baumhart and NACA Secretary John Victory are to the right. Many government and local officials were on hand for the press conference and ensuing luncheon. In the wake of World War II the military, the Atomic Energy Commission, and the NACA became interested in the use of atomic energy for propulsion and power. A Nuclear Division was established at NACA Lewis in the early 1950s. The division’s request for a 60-megawatt research reactor was approved in 1955. The semi-remote Plum Brook location was selected over 17 other possible sites. Construction of the Plum Brook Reactor Facility lasted five years. By the time of its first trial runs in 1961 the aircraft nuclear propulsion program had been cancelled. The space age had arrived, however, and the reactor would be used to study materials for a nuclear powered rocket.

Rotary Wing Propulsion Specialists' Meeting, Williamsburg, VA, Nov. 13-15, 1990, Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-01-01

Topics presented include sound diffraction at a sharp trailing edge in a supersonic flow, the MTR390 turboshaft development program, progress report of the electrostatic engine monitoring system, some corrosion resistant magnesium alloys, handling severe inlet conditions in aircraft fuel pumps, and an over view of inlet protection systems for Army aircraft. Also presented are the advanced control system architecture for the T800 engine, an expert system to perform on-line controller restructuring for abrupt model changes, an enhanced APU for the H-60 series and Sh-2G helicopters, and a linear theory of the North Atlantic blocking during January 1979.

National Dam Inspection Program. Sharpe’s Pond Dam (NDI I.D. PA-0888 DER I.D. 066-009) Susquehanna River Basin, Little Mehoopany Creek, Wyoming County, Pennsylvania. Phase I Inspection Report.

DTIC Science & Technology

1981-01-01

quadrangle. a. Drainage Area 0.99 square mile b. Discharge at Dam Site ( cfs ) Maximum known flood at dam site Unknown Outlet conduit at maximum pool...located near the left abutment. The capacity of the spillway was determined to be 35 cfs , based on the available 1.1-foot freeboard relative to the lov...peak flows of 3014 and 1507 cfs for full and 50 percent of PMF, respectively. Computer input and summary of computer output are also included in

Role of Microstructure on the Performance of UHTC's

NASA Technical Reports Server (NTRS)

Johnson, Sylvia M.; Gasch, Matthew J.; Stackpoole, Mairead; Gusman, Mike; Thornton, Jeremy

2009-01-01

UHTCs, because of their refractory nature and high thermal conductivity, are candidates for use on sharp leading edges of hypersonic vehicles. NASA Ames has been investigating the use of UHTCs in the HfB2/SiC family under NASA's Fundamental Aeronautics Program. The goal of this work has been to tailor the microstructure to improve mechanical properties and the performance in reentry conditions, as determined by arcjet testing. This talk discusses results of mechanical evaluation and arcjet testing of various materials with different microstructures, including the incorporation of high-temperature fibers in these materials to improve fracture toughness. Some preliminary information on UHTC composites will also be discussed.

Study of low Reynolds number nozzle flows, including radial pressure gradients

NASA Technical Reports Server (NTRS)

Rae, W. J.

1972-01-01

An analysis is presented of the laminar, axisymmetric flow in a nozzle, including both axial and radial variations of the pressure. The system of equations derived is believed to contain all of the terms necessary for describing the flow through a relatively sharp throat (i.e., one for which the longitudinal radius of curvature of the throat is comparable to, or less than, the transverse radius). A finite difference approximation of these equations is described, together with a computer program for finding numerical solutions. An instability was found in the starting solution; a series of attempts to eliminate this instability is described.

Impact of flow unsteadiness on maneuvers and loads of agile aircraft

NASA Technical Reports Server (NTRS)

Jarrah, M. Ameen; Ashley, Holt

1989-01-01

A program of airload measurements on a family of low-aspect-ratio delta wings with sharp leading edges, subjected to large amplitude pitch transients with angles of attack up to 90 deg, is reviewed. Even for small values of the pitch-rate parameter, representative of maneuvers anticipated for agile aircraft, the force and moment overshoots can exceed by 50 percent their steady-state values. This is explained in terms of the hysteretic behavior of the breakdown locations of leading-edge vortices. An approximate theoretical model is proposed which includes the breakdown hysteresis as part of a three-term representation of the unsteady chordwise load distribution.

Mount Sharp Panorama in White-Balanced Colors

NASA Image and Video Library

2013-03-15

This mosaic of images from the Mast Camera Mastcam on NASA Mars rover Curiosity shows Mount Sharp in a white-balanced color adjustment that makes the sky look overly blue but shows the terrain as if under Earth-like lighting.

Scintillator high-gain avalanche rushing photoconductor active-matrix flat panel imager: Zero-spatial frequency x-ray imaging properties of the solid-state SHARP sensor structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wronski, M.; Zhao, W.; Tanioka, K.

Purpose: The authors are investigating the feasibility of a new type of solid-state x-ray imaging sensor with programmable avalanche gain: scintillator high-gain avalanche rushing photoconductor active matrix flat panel imager (SHARP-AMFPI). The purpose of the present work is to investigate the inherent x-ray detection properties of SHARP and demonstrate its wide dynamic range through programmable gain. Methods: A distributed resistive layer (DRL) was developed to maintain stable avalanche gain operation in a solid-state HARP. The signal and noise properties of the HARP-DRL for optical photon detection were investigated as a function of avalanche gain both theoretically and experimentally, and themore » results were compared with HARP tube (with electron beam readout) used in previous investigations of zero spatial frequency performance of SHARP. For this new investigation, a solid-state SHARP x-ray image sensor was formed by direct optical coupling of the HARP-DRL with a structured cesium iodide (CsI) scintillator. The x-ray sensitivity of this sensor was measured as a function of avalanche gain and the results were compared with the sensitivity of HARP-DRL measured optically. The dynamic range of HARP-DRL with variable avalanche gain was investigated for the entire exposure range encountered in radiography/fluoroscopy (R/F) applications. Results: The signal from HARP-DRL as a function of electric field showed stable avalanche gain, and the noise associated with the avalanche process agrees well with theory and previous measurements from a HARP tube. This result indicates that when coupled with CsI for x-ray detection, the additional noise associated with avalanche gain in HARP-DRL is negligible. The x-ray sensitivity measurements using the SHARP sensor produced identical avalanche gain dependence on electric field as the optical measurements with HARP-DRL. Adjusting the avalanche multiplication gain in HARP-DRL enabled a very wide dynamic range which encompassed all clinically relevant medical x-ray exposures. Conclusions: This work demonstrates that the HARP-DRL sensor enables the practical implementation of a SHARP solid-state x-ray sensor capable of quantum noise limited operation throughout the entire range of clinically relevant x-ray exposures. This is an important step toward the realization of a SHARP-AMFPI x-ray flat-panel imager.« less

Long work hours and chronic insomnia are associated with needlestick and sharps injuries among hospital nurses in Taiwan: A national survey.

PubMed

Lo, Wen-Yen; Chiou, Shu-Ti; Huang, Nicole; Chien, Li-Yin

2016-12-01

Needlestick and sharps injuries are prevalent work-related injuries among nurses. Safety devices prevent only one-quarter of related injuries. More studies of modifiable risk factors are needed. To examine whether long work hours and chronic insomnia are associated with needlestick and sharps injuries among hospital nurses in Taiwan. Cross-sectional survey. This analysis included 19,386 full-time bedside nurses working in 104 hospitals across Taiwan. Participants filled out an anonymous questionnaire from July to September 2014. Chronic insomnia, needlestick injuries, and sharps injuries during the past year were each measured by a yes/no question. Multivariate logistic regression models were applied to examine the effects of long work hours and chronic insomnia on needlestick and sharps injuries, given with control for sex, marital status, educational level, age, years of practice, work unit, and hospital level in the model. More than 70% of study nurses worked long hours during the previous week (>50h: 27.5%; 41-50h: 43.2%), and 15.5% of nurses reported chronic insomnia. The percentage of sharps injuries (38.8%) was higher than that for needlestick injuries (22.4%) during the previous year among nurses. After adjusting for potential confounders, logistic regression yielded significant results showing that those who worked 41 to 50h per week, >50h per week, and had chronic insomnia were 1.17 times (95% C.I.=1.04-1.32), 1.51 times (95% C.I.=1.32-1.72), and 1.45 times (95% C.I.=1.25-1.68) more likely to experience needlestick injuries, and 1.29 times (95% C.I.=1.17-1.42), 1.37 times (95% C.I.=1.23-1.53), and 1.56 times (95% C.I.=1.37-1.77) more likely to experience sharps injuries, respectively, than those who worked fewer hours and did not have insomnia. This nationwide nurse survey showed that high rates of needlestick and sharps injuries persist in hospital nurses in Taiwan. The common problems of long work hours and chronic insomnia increase the risk of these injuries. We suggest that hospital managers follow regulations on work hours and optimize shift schedules for nurses to decrease related injuries. Copyright © 2016 Elsevier Ltd. All rights reserved.

Occupational safety among dental health-care workers

PubMed Central

Shimoji, Shigehiro; Ishihama, Kohji; Yamada, Hidefumi; Okayama, Masaki; Yasuda, Kouichi; Shibutani, Tohru; Ogasawara, Tadashi; Miyazawa, Hiroo; Furusawa, Kiyofumi

2010-01-01

Compared to other health-care workers, dental health-care workers come in close contact with patients and use a variety of sharp and high-speed rotating instruments. It is important to understand the characteristics of the occupational accidents that occur. We reviewed incident reports from April 1, 2005, to March 31, 2010, at Matsumoto Dental University Hospital. In addition, questionnaires dealing with identification of occupational safety issues, especially splash exposures, were conducted for dentists, dental hygienists, and nurses. Thirty-two occupational injuries were reported during the study period, including 23 sharp instrument injuries (71.9%), 6 splash exposures (18.8%), and 3 others. Of the six splash exposures, only two cases involved potential contamination with blood or other potentially infectious patient material. Of the 66 workers who experienced sharps injuries, 20 workers (30.3%, 20/66) reported them to the hospital work safety team. The questionnaire revealed high incident of splash exposures and conjunctiva exposures: 87.9% (51/58) and 60.3% (35/58) in dentists and 88.6% (39/44) and 61.4% (27/44) in dental hygienists. The compliance rate for routine use of protective eyewear was 60.3% (35/58) for dentists and 34.1% (15/44) for hygienists. Of the presented informational items included in the questionnaire, those that strongly persuaded respondents to use protective eyewear were ‘splatters from the patient’s mouth contain blood’ (90%, 99/110) and ‘dental operations at our clinic are performed based only on a questionnaire without serious examinations for HBV, HCV, and HIV’ (71.8%, 79/110). The reason of low compliance of protective eyewear among dentists might relate to fine dental procedures. Appropriate information is important for the motive of wearing personal protective equipment, and an early educational program may have a potential to increase compliance with the use of that equipment. PMID:23745061

Economic benefits of safety-engineered sharp devices in Belgium - a budget impact model.

PubMed

Hanmore, Emma; Maclaine, Grant; Garin, Fiona; Alonso, Alexander; Leroy, Nicolas; Ruff, Lewis

2013-11-25

Measures to protect healthcare workers where there is risk of injury or infection from medical sharps became mandatory in the European Union (EU) from May 2013. Our research objective was to estimate the net budget impact of introducing safety-engineered devices (SEDs) for prevention of needlestick injuries (NSIs) in a Belgian hospital. A 5-year incidence-based budget impact model was developed from the hospital inpatient perspective, comparing costs and outcomes with SEDs and prior-used conventional (non-safety) devices. The model accounts for device acquisition costs and costs of NSI management in 4 areas of application where SEDs are currently used: blood collection, infusion, injection and diabetes insulin administration. Model input data were sourced from the Institut National d'Assurance Maladie-Invalidité, published studies, clinical guidelines and market research. Costs are discounted at 3%. For a 420-bed hospital, 100% substitution of conventional devices by SEDs is estimated to decrease the cumulative 5-year incidence of NSIs from 310 to 75, and those associated with exposure to blood-borne viral diseases from 60 to 15. Cost savings from managing fewer NSIs more than offset increased device acquisition costs, yielding estimated 5-year overall savings of €51,710. The direction of these results is robust to a range of sensitivity and model scenario analyses. The model was most sensitive to variation in the acquisition costs of SEDs, rates of NSI associated with conventional devices, and the acquisition costs of conventional devices. NSIs are a significant potential risk with the use of sharp devices. The incidence of NSIs and the costs associated with their management can be reduced through the adoption of safer work practices, including investment in SEDs. For a Belgian hospital, the budget impact model reports that the incremental acquisition costs of SEDs are offset by the savings from fewer NSIs. The availability of more robust data for NSI reduction rates, and broadening the scope of the model to include ancillary measures for hospital conversion to SED usage, outpatient and paramedic device use, and transmission of other blood-borne diseases, would strengthen the model.

ONR (Office of Naval Research) Far East Scientific Bulletin. Volume 9, Number 2, April - June 1984,

DTIC Science & Technology

1984-06-01

minutes. The DH unit is also used for aluminum killing, removal of nonmetallic inclusions (mainly oxides ), calcium treatment for sulfide inclusion...life sciences. His scientific interests include environmental physiology and a more recent interest in membrane phenomena. Dr. lampietro is a member...and 35 kV and is applied to a 5 mm vacuum spark gap but the gap does not break down -. - until a laser pulse is focused on the sharp anode . Enough of

Observations of copolar correlation coefficient through a bright band at vertical incidence

NASA Technical Reports Server (NTRS)

Zrnic, D. S.; Raghavan, R.; Chandrasekar, V.

1994-01-01

This paper discusses an application of polarimetric measurements at vertical incidence. In particular, the correlation coefficients between linear copolar components are examined, and measurements obtained with the National Severe Storms Laboratory (NSSL)'s and National Center for Atmospheric Research (NCAR)'s polarimetric radars are presented. The data are from two well-defined bright bands. A sharp decrease of the correlation coefficient, confined to a height interval of a few hundred meters, marks the bottom of the bright band.

428th Brookhaven Lecture. Lighthouses, Light Sources and the Kinoform Route to 1nm

ScienceCinema

Evans-Lutterodt, Kenneth

2017-12-11

At Brookhaven Lab, a team of researchers has overcome a major x-ray focusing obstacle to allow the study of molecules, atoms, and advanced materials at the nanoscale, which is on the order of billionths of a meter. Their innovative method uses a type of refractive lens called a kinoform lens --similar to the kind found in lighthouses -- in order to focus the x-rays down to the extremely small spots needed for a sharp image at small dimensions.

Historical Perspectives in Frost Heave Research: The Early Works of S. Taber and G. Beskow

DTIC Science & Technology

1991-12-01

beginning of freezing. In addition, if the quite efficiently plowed by motor power, the effect of different types of soils are separated by a sharp...frozen clay is not greater than unfro- efficient forthe coarse soils (sand) in adry condition can zen clay, but in coarser soils, the coefficient of con...will reduce the heaving and smooth and slopes slightly outwards with depth. Forex - eliminate the frost boils. Of course, the effect of deep ample

Intense Ion Pulses for Radiation Effects Research

DTIC Science & Technology

2017-04-01

station; here, the time dependent beam current can be measured with a fast Faraday cup (ə ns time resolution). The transverse distribution of the...focused into a spot with a diameter of about 2 mm [8]. The helium ion current and the integrated charge ver- sus time, measured with the fast Faraday cup...target measured with the fast Faraday cup. The sharp peak in the current measurement shows the beam pulse compression from 1 μs to a few ns. The full

Dropout is a problem in lifestyle intervention programs for overweight and obese infertile women: a systematic review.

PubMed

Mutsaerts, M A Q; Kuchenbecker, W K H; Mol, B W; Land, J A; Hoek, A

2013-04-01

What are the dropout rates in lifestyle intervention programs (LIPs) for overweight and obese infertile women and can intervention- or patient-related baseline factors associated with dropout be identified in these women? The median dropout rate was 24% in overweight and obese infertile women who participated in a LIP; clinical useful intervention or patient-related factors associated with dropout could not be identified. Overweight and obese infertile women might improve their chance of conception when they improve their lifestyle and lose weight. Dropout from LIPs reduces the chance of losing considerable weight and is therefore considered to be an important limiting factor of the success of LIPs. This systematic review included 15 studies published between January 1980 and December 2012. The included studies investigated the effect of LIPs for overweight and obese infertile women with infertility. From these studies, dropout rates and intervention- and patient-related baseline factors associated with dropout, as well as weight loss and pregnancy rates, were recorded. There were 15 studies identified, of which 10 reported dropout rates. The median dropout rate was 24% (range: 0-31%). Four studies reported baseline characteristics of women who dropped out, but modifiable predictors of dropout could not be identified. Weight loss and pregnancy rates were lower in women who dropped out than in women who completed the LIPs. There were limited numbers of studies investigating patient-related factors associated with dropout. The heterogeneity in the studies precluded us from drawing firm conclusions on the relation between the type of intervention and dropout. Dropout from LIPs is a major drawback because it predisposes to less weight loss and lower pregnancy rates. Identification of predictors of dropout is needed to identify overweight and obese infertile women who are prone for dropout. These women might benefit from extra support and monitoring, to potentially increasing adherence rates, weight loss and pregnancy chances. M.A.Q.M. was supported by a research grant from the Dutch Organization for Health Research and Development (ZonMw). The department of obstetrics and gynaecology received research grants from Merck Sharpe and Dohme BV, feering pharmaceuticals, Merck Serono, the Netherlands.

SharP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Venkata, Manjunath Gorentla; Aderholdt, William F

The pre-exascale systems are expected to have a significant amount of hierarchical and heterogeneous on-node memory, and this trend of system architecture in extreme-scale systems is expected to continue into the exascale era. along with hierarchical-heterogeneous memory, the system typically has a high-performing network ad a compute accelerator. This system architecture is not only effective for running traditional High Performance Computing (HPC) applications (Big-Compute), but also for running data-intensive HPC applications and Big-Data applications. As a consequence, there is a growing desire to have a single system serve the needs of both Big-Compute and Big-Data applications. Though the system architecturemore » supports the convergence of the Big-Compute and Big-Data, the programming models and software layer have yet to evolve to support either hierarchical-heterogeneous memory systems or the convergence. A programming abstraction to address this problem. The programming abstraction is implemented as a software library and runs on pre-exascale and exascale systems supporting current and emerging system architecture. Using distributed data-structures as a central concept, it provides (1) a simple, usable, and portable abstraction for hierarchical-heterogeneous memory and (2) a unified programming abstraction for Big-Compute and Big-Data applications.« less

Stereoscopic medical imaging collaboration system

NASA Astrophysics Data System (ADS)

Okuyama, Fumio; Hirano, Takenori; Nakabayasi, Yuusuke; Minoura, Hirohito; Tsuruoka, Shinji

2007-02-01

The computerization of the clinical record and the realization of the multimedia have brought improvement of the medical service in medical facilities. It is very important for the patients to obtain comprehensible informed consent. Therefore, the doctor should plainly explain the purpose and the content of the diagnoses and treatments for the patient. We propose and design a Telemedicine Imaging Collaboration System which presents a three dimensional medical image as X-ray CT, MRI with stereoscopic image by using virtual common information space and operating the image from a remote location. This system is composed of two personal computers, two 15 inches stereoscopic parallax barrier type LCD display (LL-151D, Sharp), one 1Gbps router and 1000base LAN cables. The software is composed of a DICOM format data transfer program, an operation program of the images, the communication program between two personal computers and a real time rendering program. Two identical images of 512×768 pixcels are displayed on two stereoscopic LCD display, and both images show an expansion, reduction by mouse operation. This system can offer a comprehensible three-dimensional image of the diseased part. Therefore, the doctor and the patient can easily understand it, depending on their needs.

Property Taxes and Elderly Mobility

PubMed Central

Shan, Hui

2009-01-01

The 2000–05 housing market boom in the U.S. has caused sharp increases in residential property taxes. Housing-rich but income-poor elderly homeowners often complain about rising tax burdens, and anecdotal evidence suggests that some move to reduce their tax burden. There has been little systematic analysis, however, of the link between property tax levels and the mobility rate of elderly homeowners. This paper investigates this link using household-level panel data from the Health and Retirement Study (HRS) and a newly collected data set on state-provided property tax relief programs. These relief programs generate variation in effective property tax burdens that is not due solely to arguably endogenous local community choices about taxes and expenditure programs. The findings provide evidence suggesting that higher property taxes raise mobility among elderly homeowners. The point estimates from instrumental variable estimation using relief programs to generate instruments suggest that a $100 increase in annual property taxes is associated with a 0.73 percentage point increase in the two-year mobility rate for homeowners over the age of 50. This is an eight percent increase from the baseline two-year mobility rate of nine percent. These results are robust to alternative specifications. PMID:20161617

Flow-field in a vortex with breakdown above sharp edged delta wings

NASA Technical Reports Server (NTRS)

Hayashi, Y.; Nakaya, T.

1978-01-01

The behavior of vortex-flow, accompanied with breakdown, formed above sharp-edged delta wings, was studied experimentally as well as theoretically. Emphasis is placed particularly on the criterion for the breakdown at sufficiently large Reynolds numbers

Sharp Crater Rim with Dark Material and Boulders

NASA Image and Video Library

2012-03-02

This image from NASA Dawn spacecraft shows part of the sharp, fresh rim of a large crater on asteroid Vesta. There is some bright material slumping towards the center of this crater but this is mostly overshadowed by the dark material.

LLNL contributions to ANL Report ANL/NE-16/6 "Sharp User Manual"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Solberg, J. M.

Diablo is a Multiphysics implicit finite element code with an emphasis on coupled structural/thermal analysis. In the SHARP framework, it is used as the structural solver, and may also be used as the mesh smoother.

The Space High Angular Resolution Probe for the Infrared (SHARP-IR)

NASA Technical Reports Server (NTRS)

Rinehart, S. A.; Rizzo, M. J.; Leisawitz, D. T.; Staguhn, J. G.; Dipirro, M.; Mentzell, J. E.; Juanola-Parramon, R.; Dhabal, A.; Mundy, L. G.; Moseley, S. H.;

[Overview of sharps injuries among health-care workers].

PubMed

Gopar-Nieto, Rodrigo; Juárez-Pérez, Cuauhtémoc Arturo; Cabello-López, Alejandro; Haro-García, Luis Cuauhtémoc; Aguilar-Madrid, Guadalupe

2015-01-01

Sharps injuries are one of the most frequent health-care related accidents. It is estimated globally that 35 million workers are at risk; in Mexico there is no data available for this type of injuries. They are associated with lack of training, instrument and procedure risk, fatigue and stress. The occupational distribution is nurses 45 %, technicians 20 %, doctors 20 % and maintenance workers 5 %. The most commonly associated procedures are injection, venipuncture, suture, and insertion and manipulation of IV catheters. Hepatitis B is the most commonly transmitted agent. Emotional distress is huge as well as the cost of prophylaxis and follow-up. More than half of the injuries are not notified. The most common reasons for not reporting are: the belief that the exposure has low risk of infection, the lack of knowledge of reporting systems and the assumption that it is difficult to notify. Many strategies have been created to reduce the incidence of sharps injuries, such as: identifying the risk of blood exposure, the creation of politics to minimize the risk, the education and training to create a safe workplace, the enhancing of the reporting system, the use of double-gloving and using safety-engineered sharps devices. In many countries these politics have reduced the incidence of sharps injuries as well as the economic burden.

Sharp Injuries Among Medical Students.

PubMed

Ghasemzadeh, Iman; Kazerooni, Mitra; Davoodian, Parivash; Hamedi, Yaghoob; Sadeghi, Payam

2015-03-30

Sharp injuries threaten the health of healthcare employees. They cause the transmission of many diseases such as hepatitis B and C, AIDS, etc., which can increase the associated costs associated with them. The aim of this study was to investigate the frequency of sharp injuries among the students of Hormozgan University of Medical Sciences. This cross-sectional study was conducted during 2012-2013 in Hormozgan University of Medical Sciences, IR Iran. The target population consisted of the medical, nursing, midwifery, operating room technician, and medical laboratory students in the 2012-2013 academic year. Census sampling was conducted, and accordingly, 500 students participated in the study Data was collected using modified questionnaire of the University of San Diego's injury report form. The collected data were entered into SPSS V.19 and analyzed using descriptive statistical tests. Finally 377 students (75.4%) returned the questionnaire. Among the studied students, 184 students (39.3%) had had sharp injuries. The frequency of damaging Vein puncture was the most common mechanism of injury The prevalence of sharp injuries is high among students which can increase the risk of disease and its subsequent risks, and thus, increase the cost and stress among students. It seems that holding workshops and increasing students' awareness and skills to face these risks can be effective in mitigating them.

Process and outcome constructs for evaluating community-based participatory research projects: a matrix of existing measures.

PubMed

Sandoval, Jennifer A; Lucero, Julie; Oetzel, John; Avila, Magdalena; Belone, Lorenda; Mau, Marjorie; Pearson, Cynthia; Tafoya, Greg; Duran, Bonnie; Iglesias Rios, Lisbeth; Wallerstein, Nina

2012-08-01

Community-based participatory research (CBPR) has been widely used in public health research in the last decade as an approach to develop culturally centered interventions and collaborative research processes in which communities are directly involved in the construction and implementation of these interventions and in other application of findings. Little is known, however, about CBPR pathways of change and how these academic-community collaborations may contribute to successful outcomes. A new health CBPR conceptual model (Wallerstein N, Oetzel JG, Duran B et al. CBPR: What predicts outcomes? In: Minkler M, Wallerstein N (eds). Communication Based Participatory Research, 2nd edn. San Francisco, CA: John Wiley & Co., 2008) suggests that relationships between four components: context, group dynamics, the extent of community-centeredness in intervention and/or research design and the impact of these participatory processes on CBPR system change and health outcomes. This article seeks to identify instruments and measures in a comprehensive literature review that relates to these distinct components of the CBPR model and to present them in an organized and indexed format for researcher use. Specifically, 258 articles were identified in a review of CBPR (and related) literature from 2002 to 2008. Based on this review and from recommendations of a national advisory board, 46 CBPR instruments were identified and each was reviewed and coded using the CBPR logic model. The 46 instruments yielded 224 individual measures of characteristics in the CBPR model. While this study does not investigate the quality of the instruments, it does provide information about reliability and validity for specific measures. Group dynamics proved to have the largest number of identified measures, while context and CBPR system and health outcomes had the least. Consistent with other summaries of instruments, such as Granner and Sharpe's inventory (Granner ML, Sharpe PA. Evaluating community coalition characteristics and functioning: a summary of measurement tools. Health Educ Res 2004; 19: 514-32), validity and reliability information were often lacking, and one or both were only available for 65 of the 224 measures. This summary of measures provides a place to start for new and continuing partnerships seeking to evaluate their progress.

Increased understanding of cellulose crystallinity

USDA-ARS?s Scientific Manuscript database

According to the International Union of Crystallography, “material is a crystal if it has essentially a sharp diffraction pattern. The word essentially means that most of the intensity of the diffraction is concentrated in relatively sharp Bragg peaks, besides the always present diffuse scattering.”...

Implementation of a comprehensive pharmaceutical care program for an underserved population.

PubMed

Mascardo, Lisa A; Spading, Kimberly A; Abramowitz, Paul W

2012-07-15

The implementation of a prescription benefit program for low-income patients emphasizing clinical pharmacist services and strict formulary control is described, with a review of program expenditures and cost avoidance. In 2006, University of Iowa Hospitals and Clinics (UIHC) launched a program to provide a limited prescription benefit to indigent patients under the IowaCare Medicaid demonstration waiver. Sudden dramatic growth in IowaCare enrollment, combined with sharp budget cuts, forced UIHC pharmacy leaders to implement creative cost-control strategies: (1) the establishment of an ambulatory care clinic staffed by a clinical pharmacy specialist, (2) increased reliance on an almost exclusively generic formulary, (3) collaboration with social services staff to help secure medication assistance for patients requiring brand-name drugs, (4) optimized purchasing through the federal 340B Drug Pricing Program, and (5) the imposition of medication copayments and mailing fees for prescription refills. Now in its seventh year, the UIHC pharmacy program has expanded indigent patients' access to pharmaceutical care services while reducing their use of hospital and emergency room services and lowering program medication costs by an estimated 50% (from $2.6 million in fiscal year 2009 to $1.3 million in fiscal year 2010). The UIHC ambulatory care pharmacy implemented a prescription program in collaboration with social service workers to address the medication needs of the state's low-income and uninsured patients in a fiscally responsible manner by managing purchasing contracts, revising a generic formulary, implementing copayments and mailing fees, and reviewing medication profiles.

The History of Science as a Tool To Identify and Confront Pseudoscience

NASA Astrophysics Data System (ADS)

Rasmussen, Seth C.

2007-06-01

Many are concerned by the widespread popularity pseudoscience has achieved in modern society. While it is easy to dismiss such beliefs as belonging to the uneducated, numerous studies have shown that such beliefs are not significantly reduced by a university education. In fact, one study found that belief in astrology was largely unaffected by the completion of a U.S. science degree: students who commenced a degree program believing in astrology finished that program still believing in it. This illustrates the extent to which even a successful science education has failed to transform students’ intellectual outlook, and should raise sharp concern as to the deficiencies in our present science curriculum. Over the years various authors have given sound justification for the inclusion of a historical component in science programs. I would like to add to these arguments the fact that knowledge of science history allows one to more easily identify and confront pseudoscience and that rectifying the current deficiency of historical context in our science education may be an effective approach to change the way students view claims and ideas presented to them.

Reliability testing of the Larsen and Sharp classifications for rheumatoid arthritis of the elbow.

PubMed

Jew, Nicholas B; Hollins, Anthony M; Mauck, Benjamin M; Smith, Richard A; Azar, Frederick M; Miller, Robert H; Throckmorton, Thomas W

2017-01-01

Two popular systems for classifying rheumatoid arthritis affecting the elbow are the Larsen and Sharp schemes. To our knowledge, no study has investigated the reliability of these 2 systems. We compared the intraobserver and interobserver agreement of the 2 systems to determine whether one is more reliable than the other. The radiographs of 45 patients diagnosed with rheumatoid arthritis affecting the elbow were evaluated. Anteroposterior and lateral radiographs were deidentified and distributed to 6 evaluators (4 fellowship-trained upper extremity surgeons and 2 orthopedic trainees). Each evaluator graded all 45 radiographs according to the Larsen and Sharp scoring methods on 2 occasions, at least 2 weeks apart. Overall intraobserver reliability was 0.93 (95% confidence interval [CI], 0.90-0.95) for the Larsen system and 0.92 (95% CI, 0.86-0.96) for the Sharp classification, both indicating substantial agreement. Overall interobserver reliability was 0.70 (95% CI, 0.60-0.80) for the Larsen classification and 0.68 (95% CI, 0.54-0.81) for the Sharp system, both indicating good agreement. There were no significant differences in the intraobserver or interobserver reliability of the systems overall and no significant differences in reliability between attending surgeons and trainees for either classification system. The Larsen and Sharp systems both show substantial intraobserver reliability and good interobserver agreement for the radiographic classification of rheumatoid arthritis affecting the elbow. Differences in training level did not result in substantial variances in reliability for either system. We conclude that both systems can be reliably used to evaluate rheumatoid arthritis of the elbow by observers of varying training levels. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Different Temperature and Cooling Patterns at the Blunt and Sharp Egg Poles Reflect the Arrangement of Eggs in an Avian Clutch

PubMed Central

Šálek, Miroslav E.; Zárybnická, Markéta

2015-01-01

Incubation is an energetically demanding process during which birds apply heat to their eggs to ensure embryonic development. Parent behaviours such as egg turning and exchanging the outer and central eggs in the nest cup affect the amount of heat lost to the environment from individual eggs. Little is known, however, about whether and how egg surface temperature and cooling rates vary among the different areas of an egg and how the arrangement of eggs within the clutch influences heat loss. We performed laboratory (using Japanese quail eggs) and field (with northern lapwing eggs) experiments using infrared imaging to assess the temperature and cooling patterns of heated eggs and clutches. We found that (i) the sharp poles of individual quail eggs warmed to a higher egg surface temperature than did the blunt poles, resulting in faster cooling at the sharp poles compared to the blunt poles; (ii) both quail and lapwing clutches with the sharp poles oriented towards the clutch centre (arranged clutches) maintained higher temperatures over the central part of the clutch than occurred in those clutches where most of the sharp egg poles were oriented towards the exterior (scattered clutches); and (iii) the arranged clutches of both quail and lapwing showed slower cooling rates at both the inner and outer clutch positions than did the respective parts of scattered clutches. Our results demonstrate that egg surface temperature and cooling rates differ between the sharp and blunt poles of the egg and that the orientation of individual eggs within the nest cup can significantly affect cooling of the clutch as a whole. We suggest that birds can arrange their eggs within the nest cup to optimise thermoregulation of the clutch. PMID:25658846

Different temperature and cooling patterns at the blunt and sharp egg poles reflect the arrangement of eggs in an avian clutch.

PubMed

Šálek, Miroslav E; Zárybnická, Markéta

2015-01-01

Incubation is an energetically demanding process during which birds apply heat to their eggs to ensure embryonic development. Parent behaviours such as egg turning and exchanging the outer and central eggs in the nest cup affect the amount of heat lost to the environment from individual eggs. Little is known, however, about whether and how egg surface temperature and cooling rates vary among the different areas of an egg and how the arrangement of eggs within the clutch influences heat loss. We performed laboratory (using Japanese quail eggs) and field (with northern lapwing eggs) experiments using infrared imaging to assess the temperature and cooling patterns of heated eggs and clutches. We found that (i) the sharp poles of individual quail eggs warmed to a higher egg surface temperature than did the blunt poles, resulting in faster cooling at the sharp poles compared to the blunt poles; (ii) both quail and lapwing clutches with the sharp poles oriented towards the clutch centre (arranged clutches) maintained higher temperatures over the central part of the clutch than occurred in those clutches where most of the sharp egg poles were oriented towards the exterior (scattered clutches); and (iii) the arranged clutches of both quail and lapwing showed slower cooling rates at both the inner and outer clutch positions than did the respective parts of scattered clutches. Our results demonstrate that egg surface temperature and cooling rates differ between the sharp and blunt poles of the egg and that the orientation of individual eggs within the nest cup can significantly affect cooling of the clutch as a whole. We suggest that birds can arrange their eggs within the nest cup to optimise thermoregulation of the clutch.

Sharps injury reduction: a six-year, three-phase study comparing use of a small patient-room sharps disposal container with a larger engineered container

PubMed Central

Naisoro, W

2014-01-01

A 350-bed Sydney hospital noted excessive container-associated sharps injuries (CASI) using small sharps containers and compared the effect from 2004 to 2010 of using a larger container engineered to reduce CASI. In Phase 1 (Ph1), disposable 1.4L containers (BD Australia) were carried to/from patients’ rooms. In Phase 2 (Ph2), this stopped and a safety-engineered 32L reusable container (the Device; Sharpsmart, SteriHealth) was mounted in medication stations only and sharps were carried to and from patient rooms using kidney dishes. In Phase 3 (Ph3), the Device was wall-mounted in patient rooms. Sharps injuries were categorised as ‘during-procedure’, ‘after-procedure but before disposal’, ‘CASI’, and ‘improper disposal SI’. Disposal-related SI comprised CASI plus improper-disposal SI. Injuries per 100 full-time-equivalent staff were analysed using Chi2; p ≤ 0.05; and relative risk and 95% confidence limits were calculated. In Ph1 (small containers) 19.4% of SI were CASI and transport injuries were zero. In Ph2 (Device in medication station) CASI fell 94.9% (p <0.001); Disposal-related SI fell 71.1% (p=0.002) but transport injuries rose significantly. In Ph3 (Device in patient room) zero CASI occurred (p<0.001); Disposal-related SI fell 83.1% (p=0.001). Recapping SI fell 85.1% (p=0.01) with the Device. The Device’s volume, large aperture, passive overfill-protection and close-at-hand siting are postulated as SI reduction factors. PMID:28989381

Cannula Versus Sharp Needle for Placement of Soft Tissue Fillers: An Observational Cadaver Study.

PubMed

van Loghem, Jani A J; Humzah, Dalvi; Kerscher, Martina

2017-12-13

Soft-tissue fillers have become important products for facial rejuvenation. Deep fat compartments and facial bones lose volume during the natural aging process. For the most natural-looking results, deep volumetric injections at strategic sites are therefore preferred. Supraperiosteal placement is performed with a sharp needle or a non-traumatic cannula. The primary objective was to determine whether there is a difference in precision between supraperiosteal placement with a sharp needle compared with a non-traumatic cannula in cadaver specimens. A secondary objective was to analyze the safety profiles of both injection techniques. Cadaver heads were injected with dye material and soft-tissue fillers at multiple aesthetic facial sites on the supraperiosteum and subsequently dissected for observation of dye and filler placement. The non-traumatic cannula technique resulted in product being confined to the deep anatomic layers. In contrast, with the sharp needle technique, material was placed in multiple anatomic layers, from the periosteum to more superficial skin layers. For both techniques results were consistent for all facial sites. Although direct extrapolation from cadavers to the in vivo situation cannot be made, cannulae showed more precision in placement of product. With the sharp needle, the material was injected on the periosteum, and then migrated in a retrograde direction along the trajectory of the needle path, ending up in multiple anatomic layers. The sharp needle technique also showed a higher complication risk with intra-arterial injection occurring, even though the needle tip was positioned on the periosteum and the product was injected with the needle in constant contact with the periosteum. © 2016 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com

Ultra-high spatial resolution multi-energy CT using photon counting detector technology

NASA Astrophysics Data System (ADS)

Leng, S.; Gutjahr, R.; Ferrero, A.; Kappler, S.; Henning, A.; Halaweish, A.; Zhou, W.; Montoya, J.; McCollough, C.

2017-03-01

Two ultra-high-resolution (UHR) imaging modes, each with two energy thresholds, were implemented on a research, whole-body photon-counting-detector (PCD) CT scanner, referred to as sharp and UHR, respectively. The UHR mode has a pixel size of 0.25 mm at iso-center for both energy thresholds, with a collimation of 32 × 0.25 mm. The sharp mode has a 0.25 mm pixel for the low-energy threshold and 0.5 mm for the high-energy threshold, with a collimation of 48 × 0.25 mm. Kidney stones with mixed mineral composition and lung nodules with different shapes were scanned using both modes, and with the standard imaging mode, referred to as macro mode (0.5 mm pixel and 32 × 0.5 mm collimation). Evaluation and comparison of the three modes focused on the ability to accurately delineate anatomic structures using the high-spatial resolution capability and the ability to quantify stone composition using the multi-energy capability. The low-energy threshold images of the sharp and UHR modes showed better shape and texture information due to the achieved higher spatial resolution, although noise was also higher. No noticeable benefit was shown in multi-energy analysis using UHR compared to standard resolution (macro mode) when standard doses were used. This was due to excessive noise in the higher resolution images. However, UHR scans at higher dose showed improvement in multi-energy analysis over macro mode with regular dose. To fully take advantage of the higher spatial resolution in multi-energy analysis, either increased radiation dose, or application of noise reduction techniques, is needed.

GENERAL VIEW OF SHARP FREEZE ROOM ON LEVEL 2; LOOKING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF SHARP FREEZE ROOM ON LEVEL 2; LOOKING WEST; PIPES ON CEILING CARRIED COMPRESSED AMMONIA; NOTE NONBEARING GLAZED TILE WALLS BETWEEN COLUMNS; FLOORS ARE BRICK - Rath Packing Company, Cooler Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

Effective superelevation for large trucks on sharp curves and steep grades

DOT National Transportation Integrated Search

2002-10-01

This project was undertaken to identify the particular problems faced by trucks on sharp curves on steep grades, such as rebuilt switchback curves on mountainous two-lane, two-way roads and the high speed downgrade curves found on West Virginia's lim...

78 FR 43183 - Notice of Availability for Sharpe Permit Relinquishment Project Environmental Assessment Finding...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-19

... for Sharpe Permit Relinquishment Project Environmental Assessment Finding of No Significant Impact... Relinquishment Project Environmental Assessment (EA) Finding of No Significant Impact (FONSI). SUMMARY: On April... environment. Human environment was interpreted comprehensively to include the natural and physical environment...

Ripples Beside Pahrump Hills Outcrop at Base of Mount Sharp

NASA Image and Video Library

2014-11-18

This northeast-facing view from the lower edge of the pale Pahrump Hills outcrop at the base of Mount Sharp includes wind-sculpted ripples of sand and dust in the middle ground. It was taken by Curiosity Navcam on Nov. 13, 2014.

Overview of the relevant CFD work at Thiokol Corporation

NASA Technical Reports Server (NTRS)

Chwalowski, Pawel; Loh, Hai-Tien

1992-01-01

An in-house developed proprietary advanced computational fluid dynamics code called SHARP (Trademark) is a primary tool for many flow simulations and design analyses. The SHARP code is a time dependent, two dimensional (2-D) axisymmetric numerical solution technique for the compressible Navier-Stokes equations. The solution technique in SHARP uses a vectorizable implicit, second order accurate in time and space, finite volume scheme based on an upwind flux-difference splitting of a Roe-type approximated Riemann solver, Van Leer's flux vector splitting, and a fourth order artificial dissipation scheme with a preconditioning to accelerate the flow solution. Turbulence is simulated by an algebraic model, and ultimately the kappa-epsilon model. Some other capabilities of the code are 2-D two-phase Lagrangian particle tracking and cell blockages. Extensive development and testing has been conducted on the 3-D version of the code with flow, combustion, and turbulence interactions. The emphasis here is on the specific applications of SHARP in Solid Rocket Motor design. Information is given in viewgraph form.

Vatellini Sharp (Coleoptera, Dytiscidae) from Brazil: two new species, new records, and a checklist.

PubMed

Braga, Rafael Benzi; Ferreira, Nelson

2016-05-12

The tribe Vatellini Sharp, 1882 is composed of 55 species divided in two genera. Even though a recent revision of the tribe was made, Vatellini of the new world are weakly explored with great gaps in the distributions of species. In Brazil the knowledge is based only on a few localities. In this work two new species are described and illustrated, Vatellus caissara sp. nov. and Vatellus yanomami sp. nov.; new records are given for Brazil: Vatellus maculosus Miller, 2005 in the state of Mato Grosso, Derovatellus lentus (Wehncke, 1876) in Amazonas, Pará and Rio de Janeiro, Vatellus lateralis (Sharp, 1882) in Alagoas, Ceará, Espírito Santo, Pará, Pernambuco and Rio Grande do Sul, Vatellus sahlbergi (Sharp, 1882) in Rio de Janeiro, and Vatellus tarsatus (Laporte, 1835) in Pará. A checklist with all species of Vatellini occurring in Brazil is provided and steps for identification of the new species are added in the key of Miller (2005).

Spectrally selective solar absorber with sharp and temperature dependent cut-off based on semiconductor nanowire arrays

NASA Astrophysics Data System (ADS)

Wang, Yang; Zhou, Lin; Zheng, Qinghui; Lu, Hong; Gan, Qiaoqiang; Yu, Zongfu; Zhu, Jia

2017-05-01

Spectrally selective absorbers (SSA) with high selectivity of absorption and sharp cut-off between high absorptivity and low emissivity are critical for efficient solar energy conversion. Here, we report the semiconductor nanowire enabled SSA with not only high absorption selectivity but also temperature dependent sharp absorption cut-off. By taking advantage of the temperature dependent bandgap of semiconductors, we systematically demonstrate that the absorption cut-off profile of the semiconductor-nanowire-based SSA can be flexibly tuned, which is quite different from most of the other SSA reported so far. As an example, silicon nanowire based selective absorbers are fabricated, with the measured absorption efficiency above (below) bandgap ˜97% (15%) combined with an extremely sharp absorption cut-off (transition region ˜200 nm), the sharpest SSA demonstrated so far. The demonstrated semiconductor-nanowire-based SSA can enable a high solar thermal efficiency of ≳86% under a wide range of operating conditions, which would be competitive candidates for the concentrated solar energy utilizations.

Modeling the Geologic History of Mt. Sharp

NASA Technical Reports Server (NTRS)

Pascuzzo, A.; Allen, C.

2015-01-01

Gale is an approximately 155 km diameter crater located on the martian dichotomy boundary (5 deg S 138 deg E). Gale is estimated to have formed 3.8 - 3.5 Gya, in the late Noachian or early Hesperian. Mt. Sharp, at the center of Gale Crater, is a crescent shaped sedimentary mound that rises 5.2 km above the crater floor. Gale is one of the few craters that has a peak reaching higher than the rim of the crater wall. The Curiosity rover is currently fighting to find its way across a dune field at the northwest base of the mound searching for evidence of habitability. This study used orbital images and topographic data to refine models for the geologic history of Mt. Sharp by analyzing its morphological features. In addition, it assessed the possibility of a peak ring in Gale. The presence of a peak ring can offer important information to how Mt. Sharp was formed and eroded early in Gale's history.

Enhanced Transmissions Through Three-dimensional Cascade Sharp Waveguide Bends Using C-slit Diaphragms.

PubMed

Yang, Rui; Hu, Bowei; Zhang, Aofang; Gao, Dongxing; Wang, Hui; Shi, Ayuan; Lei, Zhenya; Yang, Pei

2017-03-21

Transmission properties through sharp rectangular waveguide bends are investigated to determine the cut-off bending angles of the wave propagation. We show that a simple metallic diaphragm at the bending corner with properly devised sub-wavelength defect apertures of C-slits would be readily to turn on the transmissions with scarce reflections of the propagating modes, while preserving the integrity of the transmitting fields soon after the bends. In particularly, our design also demonstrates the capability of eliminating all the unwanted cavity resonant transmissions that exist in the three-dimensional cascade sharp waveguide bends, and solely let the desired signals travel along the whole passage of the waveguide. The present approach, using C-slit diaphragms to support the sharp bending behaviors of the guided waves with greatly enhanced transmissions, would be especially effective in constructing novel waveguides and pave the way for the development of more compact and miniaturized electromagnetic systems that exploit these waveguide bends.

A High Order Finite Difference Scheme with Sharp Shock Resolution for the Euler Equations

NASA Technical Reports Server (NTRS)

Gerritsen, Margot; Olsson, Pelle

1996-01-01

We derive a high-order finite difference scheme for the Euler equations that satisfies a semi-discrete energy estimate, and present an efficient strategy for the treatment of discontinuities that leads to sharp shock resolution. The formulation of the semi-discrete energy estimate is based on a symmetrization of the Euler equations that preserves the homogeneity of the flux vector, a canonical splitting of the flux derivative vector, and the use of difference operators that satisfy a discrete analogue to the integration by parts procedure used in the continuous energy estimate. Around discontinuities or sharp gradients, refined grids are created on which the discrete equations are solved after adding a newly constructed artificial viscosity. The positioning of the sub-grids and computation of the viscosity are aided by a detection algorithm which is based on a multi-scale wavelet analysis of the pressure grid function. The wavelet theory provides easy to implement mathematical criteria to detect discontinuities, sharp gradients and spurious oscillations quickly and efficiently.

Room-temperature mobility above 2200 cm{sup 2}/V·s of two-dimensional electron gas in a sharp-interface AlGaN/GaN heterostructure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Jr-Tai, E-mail: jrche@ifm.liu.se; Persson, Ingemar; Nilsson, Daniel

A high mobility of 2250 cm{sup 2}/V·s of a two-dimensional electron gas (2DEG) in a metalorganic chemical vapor deposition-grown AlGaN/GaN heterostructure was demonstrated. The mobility enhancement was a result of better electron confinement due to a sharp AlGaN/GaN interface, as confirmed by scanning transmission electron microscopy analysis, not owing to the formation of a traditional thin AlN exclusion layer. Moreover, we found that the electron mobility in the sharp-interface heterostructures can sustain above 2000 cm{sup 2}/V·s for a wide range of 2DEG densities. Finally, it is promising that the sharp-interface AlGaN/GaN heterostructure would enable low contact resistance fabrication, less impurity-related scattering, andmore » trapping than the AlGaN/AlN/GaN heterostructure, as the high-impurity-contained AlN is removed.« less

Mechanisms for Selective Single-Cell Reactivation during Offline Sharp-Wave Ripples and Their Distortion by Fast Ripples.

PubMed

Valero, Manuel; Averkin, Robert G; Fernandez-Lamo, Ivan; Aguilar, Juan; Lopez-Pigozzi, Diego; Brotons-Mas, Jorge R; Cid, Elena; Tamas, Gabor; Menendez de la Prida, Liset

2017-06-21

Memory traces are reactivated selectively during sharp-wave ripples. The mechanisms of selective reactivation, and how degraded reactivation affects memory, are poorly understood. We evaluated hippocampal single-cell activity during physiological and pathological sharp-wave ripples using juxtacellular and intracellular recordings in normal and epileptic rats with different memory abilities. CA1 pyramidal cells participate selectively during physiological events but fired together during epileptic fast ripples. We found that firing selectivity was dominated by an event- and cell-specific synaptic drive, modulated in single cells by changes in the excitatory/inhibitory ratio measured intracellularly. This mechanism collapses during pathological fast ripples to exacerbate and randomize neuronal firing. Acute administration of a use- and cell-type-dependent sodium channel blocker reduced neuronal collapse and randomness and improved recall in epileptic rats. We propose that cell-specific synaptic inputs govern firing selectivity of CA1 pyramidal cells during sharp-wave ripples. Copyright © 2017 Elsevier Inc. All rights reserved.

Network state-dependent inhibition of identified hippocampal CA3 axo-axonic cells in vivo

PubMed Central

Tukker, John J; Klausberger, Thomas; Somogyi, Peter

2015-01-01

Hippocampal sharp waves are population discharges initiated by an unknown mechanism in pyramidal cell networks of CA3. Axo-axonic cells (AACs) regulate action potential generation through GABAergic synapses on the axon initial segment. We found that CA3 AACs in anesthetized rats and AACs in freely moving rats stopped firing during sharp waves, when pyramidal cells fire most. AACs fired strongly and rhythmically around the peak of theta oscillations, when pyramidal cells fire at low probability. Distinguishing AACs from other parvalbumin-expressing interneurons by their lack of detectable SATB1 transcription factor immunoreactivity, we discovered a somatic GABAergic input originating from the medial septum that preferentially targets AACs. We recorded septo-hippocampal GABAergic cells that were activated during hippocampal sharp waves and projected to CA3. We hypothesize that inhibition of AACs, and the resulting subcellular redistribution of inhibition from the axon initial segment to other pyramidal cell domains, is a necessary condition for the emergence of sharp waves promoting memory consolidation. PMID:24141313

Acupuncture, the limbic system, and the anticorrelated networks of the brain.

PubMed

Hui, Kathleen K S; Marina, Ovidiu; Liu, Jing; Rosen, Bruce R; Kwong, Kenneth K

2010-10-28

The study of the mechanism of acupuncture action was revolutionized by the use of functional magnetic resonance imaging (fMRI). Over the past decade, our fMRI studies of healthy subjects have contributed substantially to elucidating the central effect of acupuncture on the human brain. These studies have shown that acupuncture stimulation, when associated with sensations comprising deqi, evokes deactivation of a limbic-paralimbic-neocortical network, which encompasses the limbic system, as well as activation of somatosensory brain regions. These networks closely match the default mode network and the anti-correlated task-positive network described in the literature. We have also shown that the effect of acupuncture on the brain is integrated at multiple levels, down to the brainstem and cerebellum. Our studies support the hypothesis that the effect of acupuncture on the brain goes beyond the effect of attention on the default mode network or the somatosensory stimulation of acupuncture needling. The amygdala and hypothalamus, in particular, show decreased activation during acupuncture stimulation that is not commonly associated with default mode network activity. At the same time, our research shows that acupuncture stimulation needs to be done carefully, limiting stimulation when the resulting sensations are very strong or when sharp pain is elicited. When acupuncture induced sharp pain, our studies show that the deactivation was attenuated or reversed in direction. Our results suggest that acupuncture mobilizes the functionally anti-correlated networks of the brain to mediate its actions, and that the effect is dependent on the psychophysical response. In this work we also discuss multiple avenues of future research, including the role of neurotransmitters, the effect of different acupuncture techniques, and the potential clinical application of our research findings to disease states including chronic pain, major depression, schizophrenia, autism, and Alzheimer's disease. Published by Elsevier B.V.

Biomass District Heat System for Interior Rural Alaska Villages

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wall, William A.; Parker, Charles R.

2014-09-01

Alaska Village Initiatives (AVI) from the outset of the project had a goal of developing an integrated village approach to biomass in Rural Alaskan villages. A successful biomass project had to be ecologically, socially/culturally and economically viable and sustainable. Although many agencies were supportive of biomass programs in villages none had the capacity to deal effectively with developing all of the tools necessary to build a complete integrated program. AVI had a sharp learning curve as well. By the end of the project with all the completed tasks, AVI developed the tools and understanding to connect all of the dotsmore » of an integrated village based program. These included initially developing a feasibility model that created the capacity to optimize a biomass system in a village. AVI intent was to develop all aspects or components of a fully integrated biomass program for a village. This meant understand the forest resource and developing a sustainable harvest system that included the “right sized” harvest equipment for the scale of the project. Developing a training program for harvesting and managing the forest for regeneration. Making sure the type, quality, and delivery system matched the needs of the type of boiler or boilers to be installed. AVI intended for each biomass program to be of the scale that would create jobs and a sustainable business.« less

Morphology-Dependent Resonances of Spherical Droplets with Numerous Microscopic Inclusions

NASA Technical Reports Server (NTRS)

Mishchenko, Michael I.; Liu, Li; Mackowski, Daniel W.

2014-01-01

We use the recently extended superposition T-matrix method to study the behavior of a sharp Lorenz-Mie resonance upon filling a spherical micrometer-sized droplet with tens and hundreds of randomly positioned microscopic inclusions. We show that as the number of inclusions increases, the extinction cross-section peak and the sharp asymmetry-parameter minimum become suppressed, widen, and move toward smaller droplet size parameters, while ratios of diagonal elements of the scattering matrix exhibit sharp angular features indicative of a distinctly nonspherical particle. Our results highlight the limitedness of the concept of an effective refractive index of an inhomogeneous spherical particle.