Science.gov

Sample records for research varian associates

  1. The Varian story.

    PubMed

    Freeman, Ray; Morris, Gareth A

    2015-01-01

    This Perspective offers a personal view of the story of Varian NMR, a courageous initiative that began in the 1950s but came to an abrupt end some 60 years later. Without doubt, Varian leaves behind a priceless legacy, particularly in the field of structural chemistry. The highlights are set out in four main sections, named after the four seasons, but not necessarily in strict chronology. How did the accepted business practices influence the evolution, growth, and eventual demise of this exciting venture? How well did management handle an unconventional group of young scientific entrepreneurs? What does it all mean for the future of magnetic resonance? The subject can be viewed on two different levels, the Varian story itself, and the larger picture - the Silicon Valley phenomenon as a whole, with Varian considered as an interesting microcosm. PMID:25532932

  2. The Varian story

    NASA Astrophysics Data System (ADS)

    Freeman, Ray; Morris, Gareth A.

    2015-01-01

    This Perspective offers a personal view of the story of Varian NMR, a courageous initiative that began in the 1950s but came to an abrupt end some 60 years later. Without doubt, Varian leaves behind a priceless legacy, particularly in the field of structural chemistry. The highlights are set out in four main sections, named after the four seasons, but not necessarily in strict chronology. How did the accepted business practices influence the evolution, growth, and eventual demise of this exciting venture? How well did management handle an unconventional group of young scientific entrepreneurs? What does it all mean for the future of magnetic resonance? The subject can be viewed on two different levels, the Varian story itself, and the larger picture - the Silicon Valley phenomenon as a whole, with Varian considered as an interesting microcosm.

  3. Researching Teacher Associations

    ERIC Educational Resources Information Center

    Smith, Richard; Kuchah, Kuchah

    2016-01-01

    In this article, we argue not only for more research "into" English language teacher associations (TAs) but also for research to be carried out "by" and "within" TAs. That is, we advocate their becoming "Researching TAs" themselves. This suggestion derives from our recent collaborative work with/within the…

  4. Morphological plasticity in the tropical sponge Anthosigmella varians: responses to predators and wave energy.

    PubMed

    Hill, Malcolm S; Hill, April L

    2002-02-01

    The goal of the research presented here was to examine phenotypic plasticity exhibited by three morphotypes of the common Caribbean sponge Anthosigmella varians (Duchassaing & Michelotti). We were interested in examining the biotic (and, to a lesser extent, abiotic) factors responsible for branch production in this species. We also tested the hypothesis that the skeleton may serve an antipredator function in this sponge, focusing on vertebrate fish predators (i.e., angelfish) in this work. In transplant and caging experiments, unprotected forma varians replicates were immediately consumed by angelfish, while caged replicates persisted on the reef for several months. These findings support the hypothesis that predators (and not wave energy) restrict forma varians to lagoonal habitats. Branch production was not observed in A. varians forma incrustans when sponges were protected from predators or placed in predator-free, low-wave-energy environments. It is not clear from our work whether forma incrustans is capable of producing branches (i.e., whether branch production is a plastic trait in this morph). Additional field experiments demonstrated that A. varians forma varians increased spicule concentrations, compared to uninjured sponges, in response to artificial predation events, and A. varians forma rigida reduced spicule concentrations, compared to uncaged controls, when protected from predators. These findings indicate that spicule concentration is a plastic morphological trait that can be induced by damage, and that A. varians may be able to reduce spicule concentrations when environmental conditions change (e.g., in the absence of predators). The potential significance of inducible defenses and structural anti-predator defenses in sponges is discussed in relation to recent work on sponge chemical defenses.

  5. Comparison of measured Varian Clinac 21EX and TrueBeam accelerator electron field characteristics.

    PubMed

    Lloyd, Samantha A M; Zavgorodni, Sergei; Gagne, Isabelle M

    2015-07-08

    Dosimetric comparisons of radiation fields produced by Varian's newest linear accelerator, the TrueBeam, with those produced by older Varian accelerators are of interest from both practical and research standpoints. While photon fields have been compared in the literature, similar comparisons of electron fields have not yet been reported. In this work, electron fields produced by the TrueBeam are compared with those produced by Varian's Clinac 21EX accelerator. Diode measurements were taken of fields shaped with electron applicators and delivered at 100 cm SSD, as well as those shaped with photon MLCs without applicators and delivered at 70 cm SSD for field sizes ranging from 5 × 5 to 25 × 25 cm² at energies between 6 and 20 MeV. Additionally, EBT2 and EBT3 radio-chromic film measurements were taken of an MLC-shaped aperture with closed leaf pairs delivered at 70 cm SSD using 6 and 20 MeV electrons. The 6 MeV fields produced by the TrueBeam and Clinac 21EX were found to be almost indistinguishable. At higher energies, TrueBeam fields shaped by electron applicators were generally flatter and had less photon contamination compared to the Clinac 21EX. Differences in PDDs and profiles fell within 3% and 3 mm for the majority of measurements. The most notable differences for open fields occurred in the profile shoulders for the largest applicator field sizes. In these cases, the TrueBeam and Clinac 21EX data differed by as much as 8%. Our data indicate that an accurate electron beam model of the Clinac 21EX could be used as a starting point to simulate electron fields that are dosimetrically equivalent to those produced by the TrueBeam. Given that the Clinac 21EX shares head geometry with Varian's iX, Trilogy, and Novalis TX accelerators, our findings should also be applicable to these machines.

  6. Comparison of measured Varian Clinac 21EX and TrueBeam accelerator electron field characteristics.

    PubMed

    Lloyd, Samantha A M; Zavgorodni, Sergei; Gagne, Isabelle M

    2015-01-01

    Dosimetric comparisons of radiation fields produced by Varian's newest linear accelerator, the TrueBeam, with those produced by older Varian accelerators are of interest from both practical and research standpoints. While photon fields have been compared in the literature, similar comparisons of electron fields have not yet been reported. In this work, electron fields produced by the TrueBeam are compared with those produced by Varian's Clinac 21EX accelerator. Diode measurements were taken of fields shaped with electron applicators and delivered at 100 cm SSD, as well as those shaped with photon MLCs without applicators and delivered at 70 cm SSD for field sizes ranging from 5 × 5 to 25 × 25 cm² at energies between 6 and 20 MeV. Additionally, EBT2 and EBT3 radio-chromic film measurements were taken of an MLC-shaped aperture with closed leaf pairs delivered at 70 cm SSD using 6 and 20 MeV electrons. The 6 MeV fields produced by the TrueBeam and Clinac 21EX were found to be almost indistinguishable. At higher energies, TrueBeam fields shaped by electron applicators were generally flatter and had less photon contamination compared to the Clinac 21EX. Differences in PDDs and profiles fell within 3% and 3 mm for the majority of measurements. The most notable differences for open fields occurred in the profile shoulders for the largest applicator field sizes. In these cases, the TrueBeam and Clinac 21EX data differed by as much as 8%. Our data indicate that an accurate electron beam model of the Clinac 21EX could be used as a starting point to simulate electron fields that are dosimetrically equivalent to those produced by the TrueBeam. Given that the Clinac 21EX shares head geometry with Varian's iX, Trilogy, and Novalis TX accelerators, our findings should also be applicable to these machines. PMID:26219015

  7. Characterization of gamma radiation inducible thioredoxin h from Spirogyra varians.

    PubMed

    Yoon, Minchul; Yang, Ho-Yeon; Lee, Seung-Sik; Kim, Dong-Ho; Kim, Gwang-Hoon; Choi, Jong-il

    2013-08-15

    In this study, thioredoxin h (Trxh) was isolated and characterized from the fresh water green alga Spirogyra varians, which was one amongst the pool of proteins induced upon gamma radiation treatment. cDNA clones encoding S. varians thioredoxin h were isolated from a pre-constructed S. varians cDNA library. Trxh had a molecular mass of 13.5kDa and contained the canonical WCGPC active site. Recombinant Trxh showed the disulfide reduction activity, and exhibited insulin reduction activity. Also, Trxh had higher 5,5'-dithiobis(2-nitrobenzoic acid) reduction activity with Arabidopsis thioredoxin reductase (TR) than with Escherichia coli TR. Specific expression of the Trxh gene was further analyzed at mRNA and protein levels and was found to increase by gamma irradiation upto the absorbed dose of 3kGy, suggesting that Trxh may have potential functions in protection of biomolecules from gamma irradiation. PMID:23830452

  8. Characterization of gamma radiation inducible thioredoxin h from Spirogyra varians.

    PubMed

    Yoon, Minchul; Yang, Ho-Yeon; Lee, Seung-Sik; Kim, Dong-Ho; Kim, Gwang-Hoon; Choi, Jong-il

    2013-08-15

    In this study, thioredoxin h (Trxh) was isolated and characterized from the fresh water green alga Spirogyra varians, which was one amongst the pool of proteins induced upon gamma radiation treatment. cDNA clones encoding S. varians thioredoxin h were isolated from a pre-constructed S. varians cDNA library. Trxh had a molecular mass of 13.5kDa and contained the canonical WCGPC active site. Recombinant Trxh showed the disulfide reduction activity, and exhibited insulin reduction activity. Also, Trxh had higher 5,5'-dithiobis(2-nitrobenzoic acid) reduction activity with Arabidopsis thioredoxin reductase (TR) than with Escherichia coli TR. Specific expression of the Trxh gene was further analyzed at mRNA and protein levels and was found to increase by gamma irradiation upto the absorbed dose of 3kGy, suggesting that Trxh may have potential functions in protection of biomolecules from gamma irradiation.

  9. NASA/OAI Research Associates program

    NASA Technical Reports Server (NTRS)

    Keith, Theo G., Jr.

    1994-01-01

    The intent of this activity was the development of a cooperative program between the Ohio Aerospace Institute and the NASA Lewis Research Center with the objective of better preparing recent university graduates for careers in government aerospace research laboratories. The selected individuals were given the title of research associate. To accomplish the aims of this effort: (1) the research associates were introduced to the NASA Lewis Research Center and its mission/programs, (2) the research associates directly participated in NASA research and development programs, and (3) the research associates were given continuing educational opportunities in specialized areas. A number of individuals participated in this project during the discourse of this cooperative agreement. Attached are the research summaries of eight of the research associates. These reports give a very good picture of the research activities that were conducted by the associates.

  10. Varian HDR surface applicators - commissioning and clinical implementation.

    PubMed

    Iftimia, Ileana; McKee, Andrea B; Halvorsen, Per H

    2016-01-01

    The purpose of this study was to validate the dosimetric performance of Varian surface applicators with the source vertically positioned and develop procedures for clinical implementation. The Varian surface applicators with the source vertically positioned provide a wide range of apertures making them clinically advantageous, though the steep dose gradient in the region of 3-4 mm prescription depth presents multiple challenges. The following commissioning tests were performed: 1) verification of functional integrity and physical dimensions; and 2) dosimetric measurements to validate data provided by Varian as well as data obtained using the Acuros algorithm for heterogeneity corrected dose calculation. A solid water (SW) phantom was scanned and the Acuros algorithm was used to compute the dose at 5 mm depth and at surface for all applicators. Two sets of reference dose measurements were performed, with the source positioned at (i) -10 mm and (ii) -15 mm from the center of the first nominal dwell position. Measurements were taken at 5 mm depth in a SW phantom and in air at the applicator surface. The results were then compared to the vendor's data and to the Acuros calculated dose. Relative dose measurements using Gafchromic films were taken at a depth of 4 mm in SW. Percent depth ionization (PDI) measurements using ion chamber were performed in SW. The profiles generated from film measurements and the PDI plots were compared with those computed using the Acuros algorithm and vendor's data, when available. Preliminary leakage tests were performed using optically stimulated luminescence dosimeters (OSLDs) and the results were compared with Acuros predictions. All applicators were found to be functional with physical dimensions within 1 mm of specifications. For scenario (ii) measurements taken in SW at 5 mm depth and in air at the surface of each applicator were within 10% and 4% agreement with vendor's data, respectively. Compared with Acuros predictions, these

  11. Determination of Initial Beam Parameters of Varian 2100 CD Linac for Various Therapeutic Electrons Using PRIMO.

    PubMed

    Maskani, Reza; Tahmasebibirgani, Mohammad Javad; Hoseini-Ghahfarokhi, Mojtaba; Fatahiasl, Jafar

    2015-01-01

    The aim of the present research was to establish primary characteristics of electron beams for a Varian 2100C/D linear accelerator with recently developed PRIMO Monte Carlo software and to verify relations between electron energy and dose distribution. To maintain conformity of simulated and measured dose curves within 1%/1mm, mean energy, Full Width at Half Maximum (FWHM) of energy and focal spot FWHM of initial beam were changed iteratively. Mean and most probable energies were extracted from validated phase spaces and compared with related empirical equation results. To explain the importance of correct estimation of primary energy on a clinical case, computed tomography images of a thorax phantom were imported in PRIMO. Dose distributions and dose volume histogram (DVH) curves were compared between validated and artificial cases with overestimated energy. Initial mean energies were obtained of 6.68, 9.73, 13.2 and 16.4 MeV for 6, 9, 12 and 15 nominal energies, respectively. Energy FWHM reduced with increase in energy. Three mm focal spot FWHM for 9 MeV and 4 mm for other energies made proper matches of simulated and measured profiles. In addition, the maximum difference of calculated mean electrons energy at the phantom surface with empirical equation was 2.2 percent. Finally, clear differences in DVH curves of validated and artificial energy were observed as heterogeneity indexes were 0.15 for 7.21 MeV and 0.25 for 6.68 MeV. The Monte Carlo model presented in PRIMO for Varian 2100 CD was precisely validated. IAEA polynomial equations estimated mean energy more accurately than a known linear one. Small displacement of R50 changed DVH curves and homogeneity indexes. PRIMO is a user-friendly software which has suitable capabilities to calculate dose distribution in water phantoms or computerized tomographic volumes accurately.

  12. Determination of Initial Beam Parameters of Varian 2100 CD Linac for Various Therapeutic Electrons Using PRIMO.

    PubMed

    Maskani, Reza; Tahmasebibirgani, Mohammad Javad; Hoseini-Ghahfarokhi, Mojtaba; Fatahiasl, Jafar

    2015-01-01

    The aim of the present research was to establish primary characteristics of electron beams for a Varian 2100C/D linear accelerator with recently developed PRIMO Monte Carlo software and to verify relations between electron energy and dose distribution. To maintain conformity of simulated and measured dose curves within 1%/1mm, mean energy, Full Width at Half Maximum (FWHM) of energy and focal spot FWHM of initial beam were changed iteratively. Mean and most probable energies were extracted from validated phase spaces and compared with related empirical equation results. To explain the importance of correct estimation of primary energy on a clinical case, computed tomography images of a thorax phantom were imported in PRIMO. Dose distributions and dose volume histogram (DVH) curves were compared between validated and artificial cases with overestimated energy. Initial mean energies were obtained of 6.68, 9.73, 13.2 and 16.4 MeV for 6, 9, 12 and 15 nominal energies, respectively. Energy FWHM reduced with increase in energy. Three mm focal spot FWHM for 9 MeV and 4 mm for other energies made proper matches of simulated and measured profiles. In addition, the maximum difference of calculated mean electrons energy at the phantom surface with empirical equation was 2.2 percent. Finally, clear differences in DVH curves of validated and artificial energy were observed as heterogeneity indexes were 0.15 for 7.21 MeV and 0.25 for 6.68 MeV. The Monte Carlo model presented in PRIMO for Varian 2100 CD was precisely validated. IAEA polynomial equations estimated mean energy more accurately than a known linear one. Small displacement of R50 changed DVH curves and homogeneity indexes. PRIMO is a user-friendly software which has suitable capabilities to calculate dose distribution in water phantoms or computerized tomographic volumes accurately. PMID:26625800

  13. Studying Associations in Health Care Research.

    PubMed

    Flannelly, Kevin J; Flannelly, Laura T; Jankowski, Katherine R B

    2016-01-01

    This article discusses some of the types of relationships observed in healthcare research and depicts them in graphic form. The article begins by explaining two basic associations observed in chemistry and physics (Boyles' Law and Charles' Law), and illustrates how these associations are similar to curvilinear and linear associations, respectively, found in healthcare. Graphs of curvilinear associations include morbidity curves and survival and mortality curves. Several examples of linear relationships are given and methods of testing linear relationships with interval and ratio data are introduced (i.e., correlation and ordinary least-squares regression). In addition, 2 × 2 contingency tables for testing the association between categorical (or nominal) data are described. Finally, Sir Austin Bradford Hill's eight criteria for assessing causality from research on associations between variables are presented and explained. Three appendices provide interested readers with opportunities to practice interpreting selected curvilinear and linear relationships.

  14. Spirogyra varians mutant generated by high dose gamma-irradiation shows increased antioxidant properties

    NASA Astrophysics Data System (ADS)

    Lee, Hak-Jyung; Yoon, Minchul; Sung, Nak-Yun; Choi, Jong-il

    2012-08-01

    The aim of this study was to evaluate the antioxidant properties of a Spirogyra varians mutant (Mut) produced by gamma irradiation. Methanol extracts were prepared from Spirogyra varians wild-type and Mut plants, and their antioxidant activities and total phenolic content (TPC) were determined. Antioxidant parameters, including the 2-diphenyl-1-picrylhydrazyl radical-scavenging activity and ferric-reducing/antioxidant power, were higher in the Mut extract. Moreover, the TPC level was higher (P<0.05) in the Mut methanol extract. Therefore, these results suggest that gamma irradiation-induced S. varians Mut has superior antioxidant properties.

  15. Current status of the CBCT project at Varian Medical Systems

    NASA Astrophysics Data System (ADS)

    Matsinos, Evangelos

    2005-04-01

    Tracking and targeting the tumors are simultaneous processes in the image-guided radiotherapy (IGRT); this is expected to boost the efficiency, the reliability, and the safety in the treatment. Varian Medical Systems (VMS) has already produced and installed the first IGRT machine; the device comprises the VMS Clinac equipped with the On-Board Imager (OBI) component. Cone-beam CT (CBCT) imaging, one of the options of the OBI machine, aims at high-quality volumetric reconstruction. A number of calibrations are needed in order to operate our CT-imaging machines properly; they ensure that the machine components are properly aligned, the mechanical distortions are small, and yield important output that is used in the reconstruction of the actual scan data. The geometrical calibration is achieved by using a needle phantom. In order to increase the dynamic range of our imager (hence, to obtain reliable information simultaneously in the high- and the low-attenuation areas of the irradiated object), VMS has developed a dual-gain mode. Next on our agenda is the suppression of (ring, streak, and beam-hardening) artefacts in our reconstructed images and the further development of our detectors in order to remove patterns relating to lag and ghosting effects.

  16. SU-E-T-588: Characterization and Clinical Validation of the Varian Pivotal™ Treatment Solution for Prone Breast Care

    SciTech Connect

    Dewyngaert, K; Jozsef, G; Formenti, S

    2014-06-01

    Purpose: To report on the clinical validation of the Varian Pivotal™ Treatment Solution for Prone Breast Care: a platform for prone breast radiation therapy. Methods: Patients treated using Breast Conserving Radiation Therapy may benefit from treatment in the prone position with the breast tissue falling freely away from the body. This geometry allows the breast tissue to be treated while avoiding the lung and heart tissue. Eighteen patients simulated and treated using the Varian Medical Systems Pivotal™ Treatment Solution for Prone Breast Care were monitored over the course of treatment for positioning integrity and reproducibility. As this carbon-fiber platform actually replaces a portion of the couch top, indexing is inherent to its design. Patients were positioned on the couch and aligned using fiducial markers and lateral SSD to the breast fiducial point. The daily couch coordinates then serves as indicators for positioning variability with this system. Results: The variations in couch vertical, longitudinal and lateral positions were centered on a mean value of zero with standard deviations of 0.44cm, 0.75cm and 0.79cm respectively. Other factors explored were variations in distance of mid-sternum to table edge and patient rotation into the opening. The median rotation of the chest wall was found to be 11.5 degrees at CT-Simulation with a median distance of 2.5cm from midsternum to support opening. Patient rotation was not associated with either breast size or distance from edge of platform. Conclusion: The Pivotal™ Treatment solution consists of a couch top that replaces the standard top and as such is open from beneath without obstruction. This is a distinction from all other solutions which rely on a platform positioned above and indexed to the treatment couch. We found the reproducibility to be consistent with our historical measures while offering benefits of an integrated solution as stated above. supported by Professional Services Agreeement with

  17. Molecular Phylogeny, Laboratory Rearing, and Karyotype of the Bombycid Moth, Trilocha varians

    PubMed Central

    Daimon, Takaaki; Yago, Masaya; Hsu, Yu-Feng; Fujii, Tsuguru; Nakajima, Yumiko; Kokusho, Ryuhei; Abe, Hiroaki; Katsuma, Susumu; Shimada, Toru

    2012-01-01

    This study describes the molecular phylogeny, laboratory rearing, and karyotype of a bombycid moth, Trilocha varians (F. Walker) (Lepidoptera: Bombycidae), which feeds on leaves of Ficus spp. (Rosales: Moraceae). The larvae of this species were collected in Taipei city, Taiwan, and the Ryukyu Archipelago (Ishigaki and Okinawa Islands, Japan). Molecular phylogenetic analyses revealed that T. varians belongs to the subfamily Bombycinae, thus showing a close relationship to the domesticated silkworm Bombyx mori (L.), a lepidopteran model insect. A laboratory method was developed for rearing T. varians and the time required for development from the embryo to adult was determined. From oviposition to adult emergence, the developmental zero was 10.47 °C and total effective temperature was 531.2 day—degrees, i.e., approximately 30 days for one generation when reared at 28 °C. The haploid of T. varians consisted of n = 26 chromosomes. In highly polyploid somatic nuclei, females showed a large heterochromatin body, indicating that the sex chromosome system in T. varians is WZ/ZZ (female/male). The results of the present study should facilitate the utilization of T. varians as a reference species for B. mori, thereby leading to a greater understanding of the ecology and evolution of bombycid moths. PMID:22963522

  18. Training needs of clinical research associates.

    PubMed

    Ajay, Samyuktha; Bhatt, Arun

    2010-10-01

    Clinical research is a relatively new field in our country that has seen very rapid growth in the last few years. Availability of personnel appropriately trained to the specific requirements of the role they will perform in clinical research is critical for capacity expansion. Our study attempts to understand the specific areas of knowledge and skills that are important for the role of a clinical research associate. The survey was conducted among clinical research professionals from industry and academia who had more than five years of clinical research experience and held important decision making positions in clinical research (stakeholders). The survey questionnaire was designed as a matrix of various clinical research roles on the y-axis and six knowledge modules and eight skills on the x-axis. Respondents were asked to rate the importance of the knowledge /skills to the role of clinical research associates on a three point scale. In discussing results, a significant response was considered to be 50% or greater positive response from the total group. The significant findings were that general, ethics and clinical trial execution modules were rated as critical for the role of clinical research associate. Regulatory module was rated as important for the role. The other significant responses were that three of the sub-topics in the methodology module - framing a research proposal/protocol and experimental design, designing case report forms and EDCs and conducting PK studies - were rated as important and one sub topic in the data management and statistics module was rated as not important. All the skills except leadership skills were rated as critical for the role. The findings of our survey were in general on the lines of expectations of performance of the role. The general, ethics and clinical trial execution modules are critical knowledge areas for the role of a clinical research associate. No clear trends emerged for some of the other modules. Leadership

  19. Singapore Meeting of Education Research Associations Sets the Stage for Establishing a World Education Research Association

    ERIC Educational Resources Information Center

    Educational Researcher, 2009

    2009-01-01

    This article discusses a meeting of education research associations from around the world which achieved a major goal toward establishing a World Education Research Association (WERA) in Singapore on November 24-25, 2008. At the meeting, representatives reaffirmed a commitment to establish WERA and finalized several key documents for its…

  20. Commissioning of a Varian Clinac iX 6 MV photon beam using Monte Carlo simulation

    NASA Astrophysics Data System (ADS)

    Dirgayussa, I. Gde Eka; Yani, Sitti; Rhani, M. Fahdillah; Haryanto, Freddy

    2015-09-01

    Monte Carlo modelling of a linear accelerator is the first and most important step in Monte Carlo dose calculations in radiotherapy. Monte Carlo is considered today to be the most accurate and detailed calculation method in different fields of medical physics. In this research, we developed a photon beam model for Varian Clinac iX 6 MV equipped with MilleniumMLC120 for dose calculation purposes using BEAMnrc/DOSXYZnrc Monte Carlo system based on the underlying EGSnrc particle transport code. Monte Carlo simulation for this commissioning head LINAC divided in two stages are design head Linac model using BEAMnrc, characterize this model using BEAMDP and analyze the difference between simulation and measurement data using DOSXYZnrc. In the first step, to reduce simulation time, a virtual treatment head LINAC was built in two parts (patient-dependent component and patient-independent component). The incident electron energy varied 6.1 MeV, 6.2 MeV and 6.3 MeV, 6.4 MeV, and 6.6 MeV and the FWHM (full width at half maximum) of source is 1 mm. Phase-space file from the virtual model characterized using BEAMDP. The results of MC calculations using DOSXYZnrc in water phantom are percent depth doses (PDDs) and beam profiles at depths 10 cm were compared with measurements. This process has been completed if the dose difference of measured and calculated relative depth-dose data along the central-axis and dose profile at depths 10 cm is ≤ 5%. The effect of beam width on percentage depth doses and beam profiles was studied. Results of the virtual model were in close agreement with measurements in incident energy electron 6.4 MeV. Our results showed that photon beam width could be tuned using large field beam profile at the depth of maximum dose. The Monte Carlo model developed in this study accurately represents the Varian Clinac iX with millennium MLC 120 leaf and can be used for reliable patient dose calculations. In this commissioning process, the good criteria of dose

  1. Commissioning of a Varian Clinac iX 6 MV photon beam using Monte Carlo simulation

    SciTech Connect

    Dirgayussa, I Gde Eka Yani, Sitti; Haryanto, Freddy; Rhani, M. Fahdillah

    2015-09-30

    Monte Carlo modelling of a linear accelerator is the first and most important step in Monte Carlo dose calculations in radiotherapy. Monte Carlo is considered today to be the most accurate and detailed calculation method in different fields of medical physics. In this research, we developed a photon beam model for Varian Clinac iX 6 MV equipped with MilleniumMLC120 for dose calculation purposes using BEAMnrc/DOSXYZnrc Monte Carlo system based on the underlying EGSnrc particle transport code. Monte Carlo simulation for this commissioning head LINAC divided in two stages are design head Linac model using BEAMnrc, characterize this model using BEAMDP and analyze the difference between simulation and measurement data using DOSXYZnrc. In the first step, to reduce simulation time, a virtual treatment head LINAC was built in two parts (patient-dependent component and patient-independent component). The incident electron energy varied 6.1 MeV, 6.2 MeV and 6.3 MeV, 6.4 MeV, and 6.6 MeV and the FWHM (full width at half maximum) of source is 1 mm. Phase-space file from the virtual model characterized using BEAMDP. The results of MC calculations using DOSXYZnrc in water phantom are percent depth doses (PDDs) and beam profiles at depths 10 cm were compared with measurements. This process has been completed if the dose difference of measured and calculated relative depth-dose data along the central-axis and dose profile at depths 10 cm is ≤ 5%. The effect of beam width on percentage depth doses and beam profiles was studied. Results of the virtual model were in close agreement with measurements in incident energy electron 6.4 MeV. Our results showed that photon beam width could be tuned using large field beam profile at the depth of maximum dose. The Monte Carlo model developed in this study accurately represents the Varian Clinac iX with millennium MLC 120 leaf and can be used for reliable patient dose calculations. In this commissioning process, the good

  2. WE-G-BRF-07: Non-Circular Scanning Trajectories with Varian Developer Mode

    SciTech Connect

    Davis, A; Pearson, E; Pan, X; Pelizzari, C

    2014-06-15

    testing these and other new scanning trajectories. Support was provided in part by the University of Chicago Research Computing Center, Varian Medical Systems, and NIH Grants 1RO1CA120540, T32EB002103, S10 RR021039 and P30 CA14599. The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of the supporting organizations.

  3. Research Activity and the Association with Mortality

    PubMed Central

    Ozdemir, Baris A.; Karthikesalingam, Alan; Sinha, Sidhartha; Poloniecki, Jan D.; Hinchliffe, Robert J.; Thompson, Matt M.; Gower, Jonathan D.; Boaz, Annette; Holt, Peter J. E.

    2015-01-01

    Introduction The aims of this study were to describe the key features of acute NHS Trusts with different levels of research activity and to investigate associations between research activity and clinical outcomes. Methods National Institute for Health Research (NIHR) Comprehensive Clinical Research Network (CCRN) funding and number of patients recruited to NIHR Clinical Research Network (CRN) portfolio studies for each NHS Trusts were used as markers of research activity. Patient-level data for adult non-elective admissions were extracted from the English Hospital Episode Statistics (2005-10). Risk-adjusted mortality associations between Trust structures, research activity and, clinical outcomes were investigated. Results Low mortality Trusts received greater levels of funding and recruited more patients adjusted for size of Trust (n = 35, 2,349 £/bed [95% CI 1,855–2,843], 5.9 patients/bed [2.7–9.0]) than Trusts with expected (n = 63, 1,110 £/bed, [864–1,357] p<0.0001, 2.6 patients/bed [1.7–3.5] p<0.0169) or, high (n = 42, 930 £/bed [683–1,177] p = 0.0001, 1.8 patients/bed [1.4–2.1] p<0.0005) mortality rates. The most research active Trusts were those with more doctors, nurses, critical care beds, operating theatres and, made greater use of radiology. Multifactorial analysis demonstrated better survival in the top funding and patient recruitment tertiles (lowest vs. highest (odds ratio & 95% CI: funding 1.050 [1.033–1.068] p<0.0001, recruitment 1.069 [1.052–1.086] p<0.0001), middle vs. highest (funding 1.040 [1.024–1.055] p<0.0001, recruitment 1.085 [1.070–1.100] p<0.0001). Conclusions Research active Trusts appear to have key differences in composition than less research active Trusts. Research active Trusts had lower risk-adjusted mortality for acute admissions, which persisted after adjustment for staffing and other structural factors. PMID:25719608

  4. SU-C-304-02: Robust and Efficient Process for Acceptance Testing of Varian TrueBeam Linacs Using An Electronic Portal Imaging Device (EPID)

    SciTech Connect

    Yaddanapudi, S; Cai, B; Sun, B; Li, H; Noel, C; Goddu, S; Mutic, S; Harry, T; Pawlicki, T

    2015-06-15

    Purpose: The purpose of this project was to develop a process that utilizes the onboard kV and MV electronic portal imaging devices (EPIDs) to perform rapid acceptance testing (AT) of linacs in order to improve efficiency and standardize AT equipment and processes. Methods: In this study a Varian TrueBeam linac equipped with an amorphous silicon based EPID (aSi1000) was used. The conventional set of AT tests and tolerances was used as a baseline guide, and a novel methodology was developed to perform as many tests as possible using EPID exclusively. The developer mode on Varian TrueBeam linac was used to automate the process. In the current AT process there are about 45 tests that call for customer demos. Many of the geometric tests such as jaw alignment and MLC positioning are performed with highly manual methods, such as using graph paper. The goal of the new methodology was to achieve quantitative testing while reducing variability in data acquisition, analysis and interpretation of the results. The developed process was validated on two machines at two different institutions. Results: At least 25 of the 45 (56%) tests which required customer demo can be streamlined and performed using EPIDs. More than half of the AT tests can be fully automated using the developer mode, while others still require some user interaction. Overall, the preliminary data shows that EPID-based linac AT can be performed in less than a day, compared to 2–3 days using conventional methods. Conclusions: Our preliminary results show that performance of onboard imagers is quite suitable for both geometric and dosimetric testing of TrueBeam systems. A standardized AT process can tremendously improve efficiency, and minimize the variability related to third party quality assurance (QA) equipment and the available onsite expertise. Research funding provided by Varian Medical Systems. Dr. Sasa Mutic receives compensation for providing patient safety training services from Varian Medical

  5. 15 CFR 256.2 - The Research Associate Program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false The Research Associate Program. 256.2... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES RESEARCH ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities,...

  6. 15 CFR 256.2 - The Research Associate Program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific competence, and technical supervision for defined scientific or technical research by a Research Associate when such research is complementary to and compatible with scientific or technical research...

  7. 15 CFR 256.2 - The Research Associate Program.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific competence, and technical supervision for defined scientific or technical research by a Research Associate when such research is complementary to and compatible with scientific or technical research...

  8. 15 CFR 256.2 - The Research Associate Program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific competence, and technical supervision for defined scientific or technical research by a Research Associate when such research is complementary to and compatible with scientific or technical research...

  9. 15 CFR 256.2 - The Research Associate Program.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific competence, and technical supervision for defined scientific or technical research by a Research Associate when such research is complementary to and compatible with scientific or technical research...

  10. Enhanced dynamic wedge output factors for Varian 2300CD and the case for a reference database.

    PubMed

    Njeh, Christopher F

    2015-01-01

    Dose inhomogeneity in treatment planning can be compensated using physical wedges. Enhanced dynamic wedges (EDW) were introduced by Varian to overcome some of the shortcomings of physical wedges. The objectives of this study were to measure EDW output factors for 6 MV and 20 MV photon energies for a Varian 2300CD. Secondly, to review the literature in terms of published enhanced dynamic wedge output factors (EDWOF) for different Varian models and thereby add credence to the case of the validity of reference databases. The enhanced dynamic wedge output factors were measured for the Varian 2300CD for both 6MV and 20 MV photon energies. Twelve papers with published EDWOF for different Varian linac models were found in the literature. Comparing our results with the published mean, we found an excellent agreement for 6 MV EDWOF, with the percentage differences ranging from 0.01% to 0.57%, with a mean of 0.03%. The coefficient of variation of published EDWOF ranged from 0.17% to 0.85% and 0.1% to 0.9% for the for 6 MV and 18 MV photon energies, respectively. This paper provides the first published EDWOF for 20 MV photon energy. In addition, we have provided the first compendium of EDWOFs for different Varian linac models. The consistency of value across models and institution provide further support that a standard dataset of basic photon and electron dosimetry could be established as a guide for future commissioning, beam modeling, and quality assurance purposes. PMID:26699307

  11. Active heater control and regulation for the Varian VGT-8011 gyrotron

    SciTech Connect

    Harris, T.E.

    1991-10-01

    The Varian VGT-8011 gyrotron is currently being used in the new 110 GHz 2 MW ECH system installed on D3-D. This new ECH system augments the 60 GHz system which uses Varian VA-8060 gyrotrons. The new 110 GHz system will be used for ECH experiments on D3-D with a pulse width capability of 10 sec. In order to maintain a constant RF outpower level during long pulse operation, active filament-heater control and regulation is required to maintain a constant cathode current. On past D3-D experiments involving the use of Varian VA-8060 gyrotrons for ECH power, significant gyrotron heater-emission depletion was experienced for pulse widths > 300 msec. This decline in heater-emission directly results in gyrotron-cathode current droop. Since RF power from gyrotrons decreases as cathode current decreases, it is necessary to maintain a constant cathode current level during gyrotron pulses for efficient gyrotron operation. Therefore, it was determined that a filament-heater control system should be developed for the Varian VGT-8011 gyrotron which will include cathode-current feed-back. This paper discusses the mechanisms used to regulate gyrotron filament-heater voltage by using cathode-current feed-back. 1 fig.

  12. Factors Associated with Research Wrongdoing in Nigeria

    PubMed Central

    Adeleye, Omokhoa A.; Adebamowo, Clement A.

    2013-01-01

    Concerns about research wrongdoing in biomedical research are growing in developing countries, where research ethics training and research regulatory systems are just emerging. In a first-time study in Africa, medical/dental researchers (N = 132) in two states in Nigeria were interviewed on a wide range of research wrongdoings and potential predictors. Using multivariate logistic regression, significant predictors of research wrongdoing were identified. Some 22.0% admitted to at least one of fabrication, falsification, and plagiarism, the predictors of which were knowledge gaps in research ethics and pressure to publish enough papers for promotion. Acknowledging inadequate knowledge of research ethics was a predictor of admitting a wrongdoing. Systems that support ethical research, including skilled training and funding, are recommended. PMID:23324199

  13. Analysis of output trends from Varian 2100C/D and 600C/D accelerators.

    PubMed

    Grattan, M W D; Hounsell, A R

    2011-01-01

    Analysis of Varian linear accelerator output trends is reported. Two groups, consisting of four matched Varian 2100C/D and four matched Varian 600C/D accelerators, with different designs of monitor chamber, have been investigated and the data acquired from regular calibrated ion chamber/electrometer measurements of the output performance of the eight accelerators analysed. The trend of machine output with time, having removed the effect of adjusting the monitor chamber response, was compared on a monthly and annual basis for monitor chambers with ages ranging between 1 year and 7 years. The results indicate that the response is generally consistent within each set of accelerators with different monitor chamber designs. Those used in a Varian 600C/D machine result in a reduction in measured output over time, with an average monthly reduction of 0.35 ± 0.09% over the course of the first 4 years of use. The chambers used in a 2100C/D accelerator result in an increase in measured output over time, with an average monthly increase of 0.26 ± 0.09% over the course of the first 4 years of use. The output increase then reduces towards the end of this period of time, with the average monthly change falling to -0.03 ± 0.02% for the following 3 years. The output response trend was similar for all clinical energies used on the 2100C/D accelerators--6, 15 MV x-ray beams, and 4, 6, 9, 12, 16 and 20 MeV electron beams. By tracking these changes it has been possible to predict the response over time to allow appropriate adjustments in monitor chamber response to maintain a measured accelerator output within tolerance and give confidence in performance. It has also provided data to indicate the need for planned preventative intervention and indicate if the monitor chamber response is behaving as expected.

  14. Implicit Measures of Association in Psychopathology Research

    ERIC Educational Resources Information Center

    Roefs, Anne; Huijding, Jorg; Smulders, Fren T. Y.; MacLeod, Colin M.; de Jong, Peter J.; Wiers, Reinout W.; Jansen, Anita T. M.

    2011-01-01

    Validity;Measures (Individuals);Studies obtaining implicit measures of associations in "Diagnostic and Statistical Manual of Mental Disorders" (4th ed., Text Revision; American Psychiatric Association, 2000) Axis I psychopathology are organized into three categories: (a) studies comparing groups having a disorder with controls, (b) experimental…

  15. The implications of temperature-mediated plasticity in larval instar number for development within a marine invertebrate, the shrimp Palaemonetes varians.

    PubMed

    Oliphant, Andrew; Hauton, Chris; Thatje, Sven

    2013-01-01

    Variations in larval instar number are common among arthropods. Here, we assess the implications of temperature-mediated variations in larval instar number for larval development time, larval growth rates, and juvenile dry weight within the palaemonid shrimp, Palaemonetes varians. In contrast with previous literature, which focuses on terrestrial arthropods, particularly model and pest species often of laboratory lines, we use wild shrimp, which differ in their life history from previous models. Newly-hatched P. varians larvae were first reared at 5, 10, 17, 25, and 30 °C to assess their thermal scope for development. Larvae developed at 17, 25, and 30 °C. At higher temperatures, larvae developed through fewer larval instars. Two dominant developmental pathways were observed; a short pathway of four instars and a long pathway of five instars. Longer developmental pathways of six to seven instars were rarely observed (mostly at lower temperatures) and consisted of additional instars as 'repeat' instars; i.e. little developmental advance over the preceding instar. To assess the implications of temperature-mediated variation in larval instar number, newly-hatched larvae were then reared at 15, 20, and 25 °C. Again, the proportion of larvae developing through four instars increased with temperature. At all temperatures, larval development time and juvenile dry weight were greater for larvae developing through five instars. Importantly, because of the increasing proportion of larvae developing through four instars with increasing temperature, larval traits associated with this pathway (reduced development time and juvenile dry weight) became more dominant. As a consequence of increasing growth rate with temperature, and the shift in the proportion of larvae developing through four instars, juvenile dry weight was greatest at intermediate temperatures (20 °C). We conclude that at settlement P. varians juveniles do not follow the temperature-size rule; this is of

  16. The Implications of Temperature-Mediated Plasticity in Larval Instar Number for Development within a Marine Invertebrate, the Shrimp Palaemonetes varians

    PubMed Central

    Oliphant, Andrew; Hauton, Chris; Thatje, Sven

    2013-01-01

    Variations in larval instar number are common among arthropods. Here, we assess the implications of temperature-mediated variations in larval instar number for larval development time, larval growth rates, and juvenile dry weight within the palaemonid shrimp, Palaemonetes varians. In contrast with previous literature, which focuses on terrestrial arthropods, particularly model and pest species often of laboratory lines, we use wild shrimp, which differ in their life history from previous models. Newly-hatched P. varians larvae were first reared at 5, 10, 17, 25, and 30°C to assess their thermal scope for development. Larvae developed at 17, 25, and 30°C. At higher temperatures, larvae developed through fewer larval instars. Two dominant developmental pathways were observed; a short pathway of four instars and a long pathway of five instars. Longer developmental pathways of six to seven instars were rarely observed (mostly at lower temperatures) and consisted of additional instars as ‘repeat’ instars; i.e. little developmental advance over the preceding instar. To assess the implications of temperature-mediated variation in larval instar number, newly-hatched larvae were then reared at 15, 20, and 25°C. Again, the proportion of larvae developing through four instars increased with temperature. At all temperatures, larval development time and juvenile dry weight were greater for larvae developing through five instars. Importantly, because of the increasing proportion of larvae developing through four instars with increasing temperature, larval traits associated with this pathway (reduced development time and juvenile dry weight) became more dominant. As a consequence of increasing growth rate with temperature, and the shift in the proportion of larvae developing through four instars, juvenile dry weight was greatest at intermediate temperatures (20°C). We conclude that at settlement P. varians juveniles do not follow the temperature-size rule; this is of

  17. SU-F-BRE-11: Neutron Measurements Around the Varian TrueBeam Linac

    SciTech Connect

    Maglieri, R; Seuntjens, J; Kildea, J; Liang, L; DeBlois, F; Evans, M; Licea, A; Dubeau, J; Witharana, S

    2014-06-15

    Purpose: With the emergence of flattening filter free (FFF) photon beams, several authors have noted many advantages to their use. One such advantage is the decrease in neutron production by photonuclear reactions in the linac head. In the present work we investigate the reduction in neutrons from a Varian TrueBeam linac using the Nested Neutron Spectrometer (NNS, Detec). The neutron spectrum, total fluence and source strength were measured and compared for 10 MV with and without flattening filter and the effect of moderation by the room and maze was studied for the 15 MV beam. Methods: The NNS, similar to traditional Bonner sphere detectors but operated in current mode, was used to measure the neutron fluence and spectrum. The NNS was validated for use in high dose rate environments using Monte Carlo simulations and calibrated at NIST and NRC Canada. Measurements were performed at several positions within the treatment room and maze with the linac jaws closed to maximize neutron production. Results: The measurements showed a total fluence reduction between 35-40% in the room and maze when the flattening filter was removed. The neutron source strength Qn was calculated from in-room fluence measurements and was found to be 0.042 × 10{sup 2} n/Gy, 0.026 × 10{sup 2} n/Gy and 0.59 × 101{sup 2} n/Gy for the 10 MV, the 10 MV FFF and 15 MV beams, respectively. We measured ambient equivalent doses of 11 mSv/hr, 7 mSv/hr and 218 mSv/hr for the 10 MV, 10 MV FFF and 15 MV by the head. Conclusion: Our measurements revealed a decrease in total fluence, neutron source strength and equivalent dose of approximately 35-40% across the treatment room for the FFF compared to FF modes. This demonstrates, as expected, that the flattening filter is a major component of the neutron production for the TrueBeam. The authors greatly acknowledge support form the Canadian Nuclear Commission and the Natural Sciences and Engineering Research Council of Canada through the CREATE program. Co

  18. SU-E-J-235: Varian Portal Dosimetry Accuracy at Detecting Simulated Delivery Errors

    SciTech Connect

    Gordon, J; Bellon, M; Barton, K; Gulam, M; Chetty, I

    2014-06-01

    Purpose: To use receiver operating characteristic (ROC) analysis to quantify the Varian Portal Dosimetry (VPD) application's ability to detect delivery errors in IMRT fields. Methods: EPID and VPD were calibrated/commissioned using vendor-recommended procedures. Five clinical plans comprising 56 modulated fields were analyzed using VPD. Treatment sites were: pelvis, prostate, brain, orbit, and base of tongue. Delivery was on a Varian Trilogy linear accelerator at 6MV using a Millenium120 multi-leaf collimator. Image pairs (VPD-predicted and measured) were exported in dicom format. Each detection test imported an image pair into Matlab, optionally inserted a simulated error (rectangular region with intensity raised or lowered) into the measured image, performed 3%/3mm gamma analysis, and saved the gamma distribution. For a given error, 56 negative tests (without error) were performed, one per 56 image pairs. Also, 560 positive tests (with error) with randomly selected image pairs and randomly selected in-field error location. Images were classified as errored (or error-free) if percent pixels with γ<κ was < (or ≥) τ. (Conventionally, κ=1 and τ=90%.) A ROC curve was generated from the 616 tests by varying τ. For a range of κ and τ, true/false positive/negative rates were calculated. This procedure was repeated for inserted errors of different sizes. VPD was considered to reliably detect an error if images were correctly classified as errored or error-free at least 95% of the time, for some κ+τ combination. Results: 20mm{sup 2} errors with intensity altered by ≥20% could be reliably detected, as could 10mm{sup 2} errors with intensity was altered by ≥50%. Errors with smaller size or intensity change could not be reliably detected. Conclusion: Varian Portal Dosimetry using 3%/3mm gamma analysis is capable of reliably detecting only those fluence errors that exceed the stated sizes. Images containing smaller errors can pass mathematical analysis, though

  19. The Associability of CVC Pairs. Research Report.

    ERIC Educational Resources Information Center

    Montague, William E.; Kiess, Harold O.

    To obtain an a priori estimate of natural language mediators (NLM's) 320 pairs of words with the consonant-vowel-consonant-pattern (CVC's) were broken into four series of 90 pairs and presented to 240 male and female undergraduates. Pairs were shown for 15 seconds while the subjects wrote down any associative device or NLM they could generate that…

  20. Organising Continuity and Quality of the European Educational Research Association

    ERIC Educational Resources Information Center

    Jochems, Wim; Wubbels, Theo

    2014-01-01

    Research associations tend to be voluntary by nature and therefore unstable in character, and thus are subject to threat for their continuity. History has shown that the European Educational Research Association (EERA) is not an exception to this rule. Because EERA Council and the board members are volunteers with limited time, experience and…

  1. Trophic transfer of trace metals from the polychaete worm Nereis diversicolor to the polychaete N. virens and the decapod crustacean Palaemonetes varians

    USGS Publications Warehouse

    Rainbow, P.S.; Poirier, L.; Smith, B.D.; Brix, K.V.; Luoma, S.N.

    2006-01-01

    Diet is an important exposure route for the uptake of trace metals by aquatic invertebrates, with trace metal trophic transfer depending on 2 stages - assimilation and subsequent accumulation by the predator. This study investigated the trophic transfer of trace metals from the sediment-dwelling polychaete worm Nereis diversicolor from metal-rich estuarine sediments in southwestern UK to 2 predators - another polychaete N. virens (Cu, Zn, Pb, Cd, Fe) and the decapod crustacean Palaemonetes varians (Cu, Zn, Pb, Cd, Fe, Ag, As, Mn). N. virens showed net accumulation of Cu, Zn, Pb and Cd from the prey; accumulation increased with increasing prey concentration, but a coefficient of trophic transfer decreased with increasing prey concentration, probably because a higher proportion of accumulated metal in the prey is bound in less trophically available (insoluble) detoxified forms. The trace metal accumulation patterns of P. varians apparently restricted significant net accumulation of metals from the diet of N. diversicolor to just Cd. There was significant mortality of the decapods fed on the diets of metal-rich worms. Metal-rich invertebrates that have accumulated metals from the rich historical store in the sediments of particular SW England estuaries can potentially pass these metals along food chains, with accumulation and total food chain transfer depending on the metal assimilation efficiencies and accumulation patterns of the animal at each trophic level. This trophic transfer may be significant enough to have ecotoxicological effects. ?? Inter-Research 2006.

  2. Photonuclear dose calculations for high-energy photon beams from Siemens and Varian linacs.

    PubMed

    Chibani, Omar; Ma, Chang-Ming Charlie

    2003-08-01

    The dose from photon-induced nuclear particles (neutrons, protons, and alpha particles) generated by high-energy photon beams from medical linacs is investigated. Monte Carlo calculations using the MCNPX code are performed for three different photon beams from two different machines: Siemens 18 MV, Varian 15 MV, and Varian 18 MV. The linac head components are simulated in detail. The dose distributions from photons, neutrons, protons, and alpha particles are calculated in a tissue-equivalent phantom. Neutrons are generated in both the linac head and the phantom. This study includes (a) field size effects, (b) off-axis dose profiles, (c) neutron contribution from the linac head, (d) dose contribution from capture gamma rays, (e) phantom heterogeneity effects, and (f) effects of primary electron energy shift. Results are presented in terms of absolute dose distributions and also in terms of DER (dose equivalent ratio). The DER is the maximum dose from the particle (neutron, proton, or alpha) divided by the maximum photon dose, multiplied by the particle quality factor and the modulation scaling factor. The total DER including neutrons, protons, and alphas is about 0.66 cSv/Gy for the Siemens 18 MV beam (10 cm x 10 cm). The neutron DER decreases with decreasing field size while the proton (or alpha) DER does not vary significantly except for the 1 cm x 1 cm field. Both Varian beams (15 and 18 MV) produce more neutrons, protons, and alphas particles than the Siemens 18 MV beam. This is mainly due to their higher primary electron energies: 15 and 18.3 MeV, respectively, vs 14 MeV for the Siemens 18 MV beam. For all beams, neutrons contribute more than 75% of the total DER, except for the 1 cm x 1 cm field (approximately 50%). The total DER is 1.52 and 2.86 cSv/Gy for the 15 and 18 MV Varian beams (10 cm x 10 cm), respectively. Media with relatively high-Z elements like bone may increase the dose from heavy charged particles by a factor 4. The total DER is sensitive to

  3. Ethical and legal risks associated with archival research.

    PubMed

    Taube, Daniel O; Burkhardt, Susan

    1997-01-01

    Mental health facilities and practitioners commonly permit resarchers to have direct access to patients' records for the purposes of archival research without the informed consent of patient-participants. Typically these researchers have access to all information in such records as long as they agree to maintain confidentiality and remove any identifying data from subsequent research reports. Changes in the American Psychological Association's Ethical Principles (American Psychological Association, 1992) raise ethical and legal issues that require consideration by practitioners, researchers, and facility Institutional Review Boards. This article addresses these issues and provides recommendations for changes in ethical standards as well as alternative avenues for conducting research using archival mental health records.

  4. Research Administrator Salary: Association with Education, Experience, Credentials and Gender

    ERIC Educational Resources Information Center

    Shambrook, Jennifer; Roberts, Thomas J.; Triscari, Robert

    2011-01-01

    The 2010 Research Administrators Stress Perception Survey (2010 RASPerS) collected data from 1,131 research administrators on salary, years experience, educational level, Certified Research Administrator (CRA) status, and gender. Using these data, comparisons were made to show how salary levels are associated with each of these variables. Using…

  5. Evaluation of Radiation Dose and Image Quality for the Varian Cone Beam Computed Tomography System

    SciTech Connect

    Cheng, Harry C.Y.; Wu, Vincent W.C.; Liu, Eva S.F.; Kwong, Dora L.W.

    2011-05-01

    Purpose: To compare the image quality and dosimetry on the Varian cone beam computed tomography (CBCT) system between software Version 1.4.13 and Version 1.4.11 (referred to as 'new' and 'old' protocols, respectively, in the following text). This study investigated organ absorbed dose, total effective dose, and image quality of the CBCT system for the head-and-neck and pelvic regions. Methods and Materials: A calibrated Farmer chamber and two standard cylindrical Perspex CT dosimetry phantoms with diameter of 16 cm (head phantom) and 32 cm (body phantom) were used to measure the weighted cone-beam computed tomography dose index (CBCTDIw) of the Varian CBCT system. The absorbed dose of different organs was measured in a female anthropomorphic phantom with thermoluminescent dosimeters (TLD) and the total effective dose was estimated according to International Commission on Radiological Protection (ICRP) Publication 103. The dose measurement and image quality were studied for head-and-neck and pelvic regions, and comparison was made between the new and old protocols. Results: The values of the new CBCTDIw head-and-neck and pelvic protocols were 36.6 and 29.4 mGy, respectively. The total effective doses from the new head-and-neck and pelvic protocols were 1.7 and 8.2 mSv, respectively. The absorbed doses of lens for the new 200{sup o} and old 360{sup o} head-and-neck protocols were 3.8 and 59.4 mGy, respectively. The additional secondary cancer risk from daily CBCT might be up to 2.8%. Conclusions: The new Varian CBCT provided volumetric information for image guidance with acceptable image quality and lower radiation dose. This imaging tool gave a better standard for patient daily setup verification.

  6. Student Science Research Associates (SSRA) 1996 Research Journal

    SciTech Connect

    Knezovich, J.

    1996-12-01

    The following student projects are reported: SSRA water research projects, various effects on polliwogs` growth and development, effects of Willow Park Golf Course on nitrate and phosphate levels in San Leandro Creek, water quality evaluation using color infrared photography, biochemical analysis of aquatic insects, effects of miracid/calcium chloride/liquid plant food on stringless bush beans, effects of vegetable oil on bean growth, effect of river water on lima beans, effect of storm water runoff on pH and phosphate levels of Dry Creek, acid rain in Modesto, use of random amplified polymorphic DNA to study Egeria Densa, and effect of marination on formation of heterocyclic aromatic amines in cooked chicken meat.

  7. Research of Geochemical Associations of Nephelin Ores

    NASA Astrophysics Data System (ADS)

    Vulf, M.; Simonov, K.; Sazonov, A.

    The instant paper concerns research of distribution petrogenic chemical members in urtit ore body of Kia-Shaltyrsk deposit. Rocks of the deposit are ore for producing alum earth. Actuality of the subject based on outlooks of detection noble metal ore-bearing (Au, Pt, Pd, Rh, Ru) in alkaline rocks of Siberia, including rocks of Kia-Shaltyrsk deposit (Kuznetsk Alatau). The main purpose of analysis of distribution of members is directed to detection of a non-uniformity of distribution of substance and segments enriched with alum earth and noble members. The basic solved problems are following: o Creation regression models of ore body; o Definition of cumulative distribution functions of members in a contour of ore body; o The analysis of the obtained outcomes in geologic terms. For construction regression models the full-scale data was used, which was presented by the results of the spectral and silicate analyses of gold and petrogenic members containing 130 assays arranged in ore body. A non-linear multiparameter model of the ore body based on components of nephelin ore using neural net approach was constructed. For each member the corresponding distribution function is produced. The model is constructed on the following members: Au, Al2O3, SiO2, Fe2O3, CaO, MgO, SO3, R2O ((Na2O+K2O) -1) and losses of burning. The error of model forecasting membersS concentrations was from 0.02 up to 20%. Large errors basically connected with assays located near contact of ore body and ad- jacent strata or with very high concentrations of members; also they can be connected with different genesis of rocks or superposition of other processes. The analysis of concentrations of members and normalised absolute errors of the fore- cast has shown, that all members can be sectioned into two groups: first: Al2O3, SiO2, R2O, Fe2O3 and second: Au, losses of burning, CaO, MgO, SO3. The distribution of 1 gold is tightly connected with calcium and losses of burning and spatially linked with zones

  8. Inhomogeneity effect in Varian Trilogy Clinac iX 10 MV photon beam using EGSnrc and Geant4 code system

    NASA Astrophysics Data System (ADS)

    Yani, S.; Rhani, M. F.; Haryanto, F.; Arif, I.

    2016-08-01

    Treatment fields consist of tissue other than water equivalent tissue (soft tissue, bones, lungs, etc.). The inhomogeneity effect can be investigated by Monte Carlo (MC) simulation. MC simulation of the radiation transport in an absorbing medium is the most accurate method for dose calculation in radiotherapy. The aim of this work is to evaluate the effect of inhomogeneity phantom on dose calculations in photon beam radiotherapy obtained by different MC codes. MC code system EGSnrc and Geant4 was used in this study. Inhomogeneity phantom dimension is 39.5 × 30.5 × 30 cm3 and made of 4 material slices (12.5 cm water, 10 cm aluminium, 5 cm lung and 12.5 cm water). Simulations were performed for field size 4 × 4 cm2 at SSD 100 cm. The spectrum distribution Varian Trilogy Clinac iX 10 MV was used. Percent depth dose (PDD) and dose profile was investigated in this research. The effects of inhomogeneities on radiation dose distributions depend on the amount, density and atomic number of the inhomogeneity, as well as on the quality of the photon beam. Good agreement between dose distribution from EGSnrc and Geant4 code system in inhomogeneity phantom was observed, with dose differences around 5% and 7% for depth doses and dose profiles.

  9. Proteomic analysis of Spirogyra varians mutant with high starch content and growth rate induced by gamma irradiation.

    PubMed

    Yoon, Minchul; Choi, Jong-il; Kim, Gwang Hoon; Kim, Dong-Ho; Park, Don-Hee

    2013-06-01

    This study was conducted to develop a high-efficiency strain of Spirogyra varians for the production of biomass by radiation breeding. The characteristics of wild-type and mutant S. varians were analyzed through phenomenological and proteomic observations. The results of our phenomenological observations of the S. varians mutant demonstrated increases in growth rate and content of chlorophyll a, b, and a + b; in particular, a significant threefold increase was observed in starch accumulation. Proteomic analysis to investigate the differences in expression between wild-type and mutant proteins identified 18 proteins with significantly different expressions. From the literature review, it was confirmed that the up-regulated proteins were mainly involved in photosynthesis, carbohydrate biosynthesis, and energy metabolism. These results suggest the possibility of algae development by radiation breeding for the production of biofuel. PMID:23370702

  10. Proteomic analysis of Spirogyra varians mutant with high starch content and growth rate induced by gamma irradiation.

    PubMed

    Yoon, Minchul; Choi, Jong-il; Kim, Gwang Hoon; Kim, Dong-Ho; Park, Don-Hee

    2013-06-01

    This study was conducted to develop a high-efficiency strain of Spirogyra varians for the production of biomass by radiation breeding. The characteristics of wild-type and mutant S. varians were analyzed through phenomenological and proteomic observations. The results of our phenomenological observations of the S. varians mutant demonstrated increases in growth rate and content of chlorophyll a, b, and a + b; in particular, a significant threefold increase was observed in starch accumulation. Proteomic analysis to investigate the differences in expression between wild-type and mutant proteins identified 18 proteins with significantly different expressions. From the literature review, it was confirmed that the up-regulated proteins were mainly involved in photosynthesis, carbohydrate biosynthesis, and energy metabolism. These results suggest the possibility of algae development by radiation breeding for the production of biofuel.

  11. The Creation of the European Social Work Research Association

    ERIC Educational Resources Information Center

    Taylor, Brian J.; Sharland, Elaine

    2015-01-01

    As the social work profession matures, the need for robust knowledge becomes more pressing. Greater coordination is required to develop the research community and an infrastructure to support this nationally and internationally. This article discusses the foundation, in 2014, of the European Social Work Research Association and its roots in the…

  12. SU-E-T-543: Measurement of Neutron Activation From Different High Energy Varian Linear Accelerators

    SciTech Connect

    Thatcher, T; Madsen, S; Sudowe, R; Meigooni, A Soleimani

    2015-06-15

    Purpose: Linear accelerators producing photons above 10 MeV may induce photonuclear reactions in high Z components of the accelerator. These liberated neutrons can then activate the structural components of the accelerator and other materials in the beam path through neutron capture reactions. The induced activity within the accelerator may contribute to additional dose to both patients and personnel. This project seeks to determine the total activity and activity per activated isotope following irradiation in different Varian accelerators at energies above 10 MeV. Methods: A Varian 21IX accelerator was used to irradiate a 30 cm × 30 cm × 20 cm solid water phantom with 15 MV x-rays. The phantom was placed at an SSD of 100 cm and at the center of a 20 cm × 20 cm field. Activation induced gamma spectra were acquired over a 5 minute interval after 1 and 15 minutes from completion of the irradiation. All measurements were made using a CANBERRA Falcon 5000 Portable HPGe detector. The majority of measurements were made in scattering geometry with the detector situated at 90° to the incident beam, 30 cm from the side of the phantom and approximately 10 cm from the top. A 5 minute background count was acquired and automatically subtracted from all subsequent measurements. Photon spectra were acquired for both open and MLC fields. Results: Based on spectral signatures, nuclides have been identified and their activities calculated for both open and MLC fields. Preliminary analyses suggest that activities from the activation products in the microcurie range. Conclusion: Activation isotopes have been identified and their relative activities determined. These activities are only gross estimates since efficiencies have not been determined for this source-detector geometry. Current efforts are focused on accurate determination of detector efficiencies using Monte Carlo calculations.

  13. A novel technique for VMAT QA with EPID in cine mode on a Varian TrueBeam linac.

    PubMed

    Liu, Bo; Adamson, Justus; Rodrigues, Anna; Zhou, Fugen; Yin, Fang-fang; Wu, Qiuwen

    2013-10-01

    Volumetric modulated arc therapy (VMAT) is a relatively new treatment modality for dynamic photon radiation therapy. Pre-treatment quality assurance (QA) is necessary and many efforts have been made to apply electronic portal imaging device (EPID)-based IMRT QA methods to VMAT. It is important to verify the gantry rotation speed during delivery as this is a new variable that is also modulated in VMAT. In this paper, we present a new technique to perform VMAT QA using an EPID. The method utilizes EPID cine mode and was tested on Varian TrueBeam in research mode. The cine images were acquired during delivery and converted to dose matrices after profile correction and dose calibration. A sub-arc corresponding to each cine image was extracted from the original plan and its portal image prediction was calculated. Several analyses were performed including 3D γ analysis (2D images + gantry angle axis), 2D γ analysis, and other statistical analyses. The method was applied to 21 VMAT photon plans of 3 photon energies. The accuracy of the cine image information was investigated. Furthermore, this method's sensitivity to machine delivery errors was studied. The pass rate (92.8 ± 1.4%) for 3D γ analysis was comparable to those from Delta(4) system (99.9 ± 0.1%) under similar criteria (3%, 3 mm, 5% threshold and 2° angle to agreement) at 6 MV. The recorded gantry angle and start/stop MUs were found to have sufficient accuracy for clinical QA. Machine delivery errors can be detected through combined analyses of 3D γ, gantry angle, and percentage dose difference. In summary, we have developed and validated a QA technique that can simultaneously verify the gantry angle and delivered MLC fluence for VMAT treatment.This technique is efficient and its accuracy is comparable to other QA methods.

  14. A novel technique for VMAT QA with EPID in cine mode on a Varian TrueBeam linac

    NASA Astrophysics Data System (ADS)

    Liu, Bo; Adamson, Justus; Rodrigues, Anna; Zhou, Fugen; Yin, Fang-fang; Wu, Qiuwen

    2013-10-01

    Volumetric modulated arc therapy (VMAT) is a relatively new treatment modality for dynamic photon radiation therapy. Pre-treatment quality assurance (QA) is necessary and many efforts have been made to apply electronic portal imaging device (EPID)-based IMRT QA methods to VMAT. It is important to verify the gantry rotation speed during delivery as this is a new variable that is also modulated in VMAT. In this paper, we present a new technique to perform VMAT QA using an EPID. The method utilizes EPID cine mode and was tested on Varian TrueBeam in research mode. The cine images were acquired during delivery and converted to dose matrices after profile correction and dose calibration. A sub-arc corresponding to each cine image was extracted from the original plan and its portal image prediction was calculated. Several analyses were performed including 3D γ analysis (2D images + gantry angle axis), 2D γ analysis, and other statistical analyses. The method was applied to 21 VMAT photon plans of 3 photon energies. The accuracy of the cine image information was investigated. Furthermore, this method's sensitivity to machine delivery errors was studied. The pass rate (92.8 ± 1.4%) for 3D γ analysis was comparable to those from Delta4 system (99.9 ± 0.1%) under similar criteria (3%, 3 mm, 5% threshold and 2° angle to agreement) at 6 MV. The recorded gantry angle and start/stop MUs were found to have sufficient accuracy for clinical QA. Machine delivery errors can be detected through combined analyses of 3D γ, gantry angle, and percentage dose difference. In summary, we have developed and validated a QA technique that can simultaneously verify the gantry angle and delivered MLC fluence for VMAT treatment.This technique is efficient and its accuracy is comparable to other QA methods.

  15. DOE-NREL Minority University Research Associates Program

    SciTech Connect

    Posey Eddy, F.

    2005-01-01

    The DOE-NREL Minority University Research Associates Program (MURA) encourages minority students to pursue careers in science and technology. In this program, undergraduate students work with principal investigators at their universities to perform research projects on solar technology. Then, students are awarded summer internships in industry or at national laboratories, such as NREL, during the summer. Because of its success, the program has been expanded to include additional minority-serving colleges and universities and all solar energy technologies.

  16. Children's understanding of the risks and benefits associated with research

    PubMed Central

    Burke, T; Abramovitch, R; Zlotkin, S

    2005-01-01

    Objective: The objective of the current study was to maximise the amount of information children and adolescents understand about the risks and benefits associated with participation in a biomedical research study. Design: Participants were presented with one of six hypothetical research protocols describing how to fix a fractured thigh using either a "standard" cast or "new" pins procedure. Risks and benefits associated with each of the treatment options were manipulated so that for each one of the six protocols there was either a correct or ambiguous choice. Participants and setting: Two hundred and fifty one children, ages 6–15 (53% boys), and 237 adults (30% men) were interviewed while waiting for a clinic appointment at the Hospital for Sick Children. Results: Using standardised procedures and questionnaires, it was determined that most participants, regardless of age group, were able to understand the basic purpose and procedures involved in the research, and most were able to choose the "correct" operation. The younger children, however, showed an overall preference for a cast operation, whereas the older participants were more likely to choose the pins. Conclusions: By creating age appropriate modules of information, children as young as six years can understand potentially difficult and complex concepts such as the risks and benefits associated with participation in biomedical research. It appears, however, that different criteria were used for treatment preference, regardless of associated risks; older participants tended to opt for mobility (the pins procedure) whereas younger participants stayed with the more familiar cast operation. PMID:16319237

  17. American Educational Research Association Paper Abstracts, 1967 Annual Meeting.

    ERIC Educational Resources Information Center

    Page, Ellis B., Ed.

    This document contains abstracts of approximately 300 papers presented at the 1967 annual meeting of the American Educational Research Association. A sampling of the varied subjects covered includes: dynamics of the school board role, concept learning, programed instruction, administrative behavior and organizational characteristics, correlates of…

  18. Visibility of Diversity within Association of Research Libraries Websites

    ERIC Educational Resources Information Center

    Mestre, Lori S.

    2011-01-01

    Libraries in the United States have worked towards developing more inclusive environments and programs. This inclusiveness should also extend to the online library presence. This article provides results of a web page scan of all Association of Research Libraries (ARL) in the United States to document the visibility of diversity on their pages. A…

  19. Association of Researcher Characteristics with Views on Return of Incidental Findings from Genomic Research.

    PubMed

    Wynn, Julia; Martinez, Josue; Duong, Jimmy; Zhang, Yuan; Phelan, Jo; Fyer, Abby; Klitzman, Robert; Appelbaum, Paul S; Chung, Wendy K

    2015-10-01

    Whole exome/ genome sequencing (WES/WGS) is now commonly used in research and is increasingly used in clinical care to identify the genetic basis of rare and unknown diseases. The management of incidental findings (IFs) generated through these analyses is debated within the research community. To examine how views regarding genomic research IFs are associated with researcher characteristics and experiences, we surveyed genetic professionals and assessed the effect of professional background and experience on their opinions. Researchers who did not have clinical training, provide clinical care to research participants, or have prior experience returning research results were in general more inclined to offer return of IFs than their colleagues with these characteristics. Understanding this will be important to fully appreciate the impact that policies on return of genetic IFs could have on participants, researchers, and genomic research.

  20. Association of researcher characteristics with views on return of incidental findings from genomic research

    PubMed Central

    Wynn, Julia; Martinez, Josue; Duong, Jimmy; Zhang, Yuan; Phelan, Jo; Fyer, Abby; Klitzman, Robert; Appelbaum, Paul S.; Chung, Wendy K.

    2015-01-01

    Whole exome/genome sequencing (WES/WGS) is now commonly used in research and is increasingly used in clinical care to identify the genetic basis of rare and unknown diseases. The management of incidental findings (IFs) generated through these analyses is debated within the research community. To examine how views regarding genomic research IFs are associated with researcher characteristics and experiences, we surveyed genetic professionals and assessed the effect of professional background and experience on their opinions. Researchers who did not have clinical training, provide clinical care to research participants, or have prior experience returning research results were in general more inclined to offer return of IFs than their colleagues with these characteristics. Understanding this will be important to fully appreciate the impact that policies on return of genetic IFs could have on participants, researchers, and genomic research. PMID:25592144

  1. Research Note--Online Dissemination of Research: Are Professional Associations Making the Grade?

    ERIC Educational Resources Information Center

    Borah, Elisa Vinson; Aguiniga, Donna M.

    2013-01-01

    Efficient and practical means of disseminating research to social workers are needed. The authors examined how 10 social work and 10 other helping profession association websites used their sites to disseminate research to their members. A rubric was used to rate the websites in 4 domains: (1) promotion, (2) accessibility, (3) dissemination, and…

  2. Research Dilemmas Associated with Photo Elicitation in Comparative Early Childhood Education Research

    ERIC Educational Resources Information Center

    Birkeland, Asta

    2013-01-01

    Photo elicitation has become an important method to produce data in qualitative research. There is quite an extensive literature indicating the benefits of photo elicitation in order to facilitate collaboration in meaning making between researcher and the interviewee. This article addresses dilemmas associated with using photo elicitation in a…

  3. Genome-wide association studies in pharmacogenetics research debate

    PubMed Central

    Bailey, Kent R; Cheng, Cheng

    2016-01-01

    Will genome-wide association studies (GWAS) ‘work’ for pharmacogenetics research? This question was the topic of a staged debate, with pro and con sides, aimed to bring out the strengths and weaknesses of GWAS for pharmacogenetics studies. After a full day of seminars at the Fifth Statistical Analysis Workshop of the Pharmacogenetics Research Network, the lively debate was held – appropriately – at Goonies Comedy Club in Rochester (MN, USA). The pro side emphasized that the many GWAS successes for identifying genetic variants associated with disease risk show that it works; that the current genotyping platforms are efficient, with good imputation methods to fill in missing data; that its global assessment is always a success even if no significant associations are detected; and that genetic effects are likely to be large because humans have not evolved in a drug-therapy environment. By contrast, the con side emphasized that we have limited knowledge of the complexity of the genome; limited clinical phenotypes compromise studies; the likely multifactorial nature of drug response clouding the small genetic effects; and limitations of sample size and replication studies in pharmacogenetic studies. Lively and insightful discussions emphasized further research efforts that might benefit GWAS in pharmacogenetics. PMID:20235786

  4. Flocculation and adsorption of enzymes during growth of a moderate halophile, Micrococcus varians var. Halophilus.

    PubMed

    Kamekura, M; Onishi, H

    1978-06-01

    Flocculation of a moderate halophile, Micrococcus varians ATCC 2197, occurred during growth in complex medium containing 3 M NaCl and a concentration of MgSO4 and KH2PO4 greater than 40 and 14 mM, respectively. Extracellular nuclease activity was absent in the flocculated cultures. Repeated washing of flocs by Mg2+-free Tris buffer containing 3 M NaCl, lowering of pH value of floc suspension below 6.3, or addition of ethylenediaminetetraacetic acid resulted in complete dissociation of the flocs and release of Mg2+ ions as well as nuclease and amylase. Inhibition of extracellular enzyme production accompanied by flocculation appeared to be the result of adsorption of enzyme proteins to surfaces of the flocs, but not of inhibition of biosynthesis. Floc formation could also occur in media containing 18 mM CaCl2 and 3.0 mM KH2PO4, but the Ca flocs were not deflocculated by washing with Ca2+-free buffer, suggesting that the affinity of Ca2+ for cell envelopes was stronger than that of Mg2+. It was also observed that most halophilic Planococcus and Micrococcus flocculated in the presence of MgSO4 and phosphate but halophilic Pseudomonas, Acinetobacter, and Bacillus did not.

  5. Quality assurance of electron beams using a Varian electronic portal imaging device

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Heaton, R.; Norrlinger, B.; Islam, M.

    2013-08-01

    The feasibility of utilizing an electronic portal imaging device (EPID) for the quality assurance of electron beams was investigated. This work was conducted on a Varian 2100iX machine equipped with an amorphous silicon (aS1000) portal imager. The linearity of the imager pixel response as a function of exposed dose was first confirmed. The short-term reproducibility of the EPID response to electron beams was verified. Low (6 MeV), medium (12 MeV) and high (20 MeV) energies were tested, each along with small (6 × 6 cm2), medium (10 × 10 cm2) and large (20 × 20 cm2) applicators. Acquired EPID images were analyzed using an in-house MATLAB code for radiation field size, penumbra, symmetry and flatness. Field sizes and penumbra values agreed with those from film dosimetry to within 1 mm. Field symmetry and flatness constancies were measured over a period of three weeks. The results indicate that EPID can be used for routine quality assurance of electron beams.

  6. A self-sufficient method for calibration of Varian electronic portal imaging device

    NASA Astrophysics Data System (ADS)

    Sun, Baozhou; Yaddanapudi, Sridhar; Goddu, Sreekrishna M.; Mutic, Sasa

    2015-01-01

    Electronic portal imaging device (EPID) is currently used for dosimetric verification of IMRT fields and linac quality assurance (QA). It is critical to understand the dosimetric response and perform an accurate and robust calibration of EPID. We present the implementation of an efficient method for the calibration and the validation of a Varian EPID, which relies only on data collected with that specific device. The calibration method is based on images obtained with five shifts of EPID panel. With this method, the relative gain (sensitivity) of each element of a detector matrix is calculated and applied on top of the calibration determined with the flood-field procedure. The calibration procedure was verified using a physical wedge inserted in the beam line and the corrected profile shows consistent results with the measurements using a calibrated 2D array. This method does not rely on the beam profile used in the flood-field calibration process, which allows EPID calibration in 10 minutes with no additional equipment compared to at least 2 hours to obtain beam profile and scanning beam equipment requirement with the conventional method.

  7. Neutron dose measurements of Varian and Elekta linacs by TLD600 and TLD700 dosimeters and comparison with MCNP calculations.

    PubMed

    Nedaie, Hassan Ali; Darestani, Hoda; Banaee, Nooshin; Shagholi, Negin; Mohammadi, Kheirollah; Shahvar, Arjang; Bayat, Esmaeel

    2014-01-01

    High-energy linacs produce secondary particles such as neutrons (photoneutron production). The neutrons have the important role during treatment with high energy photons in terms of protection and dose escalation. In this work, neutron dose equivalents of 18 MV Varian and Elekta accelerators are measured by thermoluminescent dosimeter (TLD) 600 and TLD700 detectors and compared with the Monte Carlo calculations. For neutron and photon dose discrimination, first TLDs were calibrated separately by gamma and neutron doses. Gamma calibration was carried out in two procedures; by standard 60Co source and by 18 MV linac photon beam. For neutron calibration by (241)Am-Be source, irradiations were performed in several different time intervals. The Varian and Elekta linac heads and the phantom were simulated by the MCNPX code (v. 2.5). Neutron dose equivalent was calculated in the central axis, on the phantom surface and depths of 1, 2, 3.3, 4, 5, and 6 cm. The maximum photoneutron dose equivalents which calculated by the MCNPX code were 7.06 and 2.37 mSv.Gy(-1) for Varian and Elekta accelerators, respectively, in comparison with 50 and 44 mSv.Gy(-1) achieved by TLDs. All the results showed more photoneutron production in Varian accelerator compared to Elekta. According to the results, it seems that TLD600 and TLD700 pairs are not suitable dosimeters for neutron dosimetry inside the linac field due to high photon flux, while MCNPX code is an appropriate alternative for studying photoneutron production.

  8. Neutron dose measurements of Varian and Elekta linacs by TLD600 and TLD700 dosimeters and comparison with MCNP calculations

    PubMed Central

    Nedaie, Hassan Ali; Darestani, Hoda; Banaee, Nooshin; Shagholi, Negin; Mohammadi, Kheirollah; Shahvar, Arjang; Bayat, Esmaeel

    2014-01-01

    High-energy linacs produce secondary particles such as neutrons (photoneutron production). The neutrons have the important role during treatment with high energy photons in terms of protection and dose escalation. In this work, neutron dose equivalents of 18 MV Varian and Elekta accelerators are measured by thermoluminescent dosimeter (TLD) 600 and TLD700 detectors and compared with the Monte Carlo calculations. For neutron and photon dose discrimination, first TLDs were calibrated separately by gamma and neutron doses. Gamma calibration was carried out in two procedures; by standard 60Co source and by 18 MV linac photon beam. For neutron calibration by 241Am-Be source, irradiations were performed in several different time intervals. The Varian and Elekta linac heads and the phantom were simulated by the MCNPX code (v. 2.5). Neutron dose equivalent was calculated in the central axis, on the phantom surface and depths of 1, 2, 3.3, 4, 5, and 6 cm. The maximum photoneutron dose equivalents which calculated by the MCNPX code were 7.06 and 2.37 mSv.Gy-1 for Varian and Elekta accelerators, respectively, in comparison with 50 and 44 mSv.Gy-1 achieved by TLDs. All the results showed more photoneutron production in Varian accelerator compared to Elekta. According to the results, it seems that TLD600 and TLD700 pairs are not suitable dosimeters for neutron dosimetry inside the linac field due to high photon flux, while MCNPX code is an appropriate alternative for studying photoneutron production. PMID:24600167

  9. Optimization of image quality and dose for Varian aS500 electronic portal imaging devices (EPIDs)

    NASA Astrophysics Data System (ADS)

    McGarry, C. K.; Grattan, M. W. D.; Cosgrove, V. P.

    2007-12-01

    This study was carried out to investigate whether the electronic portal imaging (EPI) acquisition process could be optimized, and as a result tolerance and action levels be set for the PIPSPro QC-3V phantom image quality assessment. The aim of the optimization process was to reduce the dose delivered to the patient while maintaining a clinically acceptable image quality. This is of interest when images are acquired in addition to the planned patient treatment, rather than images being acquired using the treatment field during a patient's treatment. A series of phantoms were used to assess image quality for different acquisition settings relative to the baseline values obtained following acceptance testing. Eight Varian aS500 EPID systems on four matched Varian 600C/D linacs and four matched Varian 2100C/D linacs were compared for consistency of performance and images were acquired at the four main orthogonal gantry angles. Images were acquired using a 6 MV beam operating at 100 MU min-1 and the low-dose acquisition mode. Doses used in the comparison were measured using a Farmer ionization chamber placed at dmax in solid water. The results demonstrated that the number of reset frames did not have any influence on the image contrast, but the number of frame averages did. The expected increase in noise with corresponding decrease in contrast was also observed when reducing the number of frame averages. The optimal settings for the low-dose acquisition mode with respect to image quality and dose were found to be one reset frame and three frame averages. All patients at the Northern Ireland Cancer Centre are now imaged using one reset frame and three frame averages in the 6 MV 100 MU min-1 low-dose acquisition mode. Routine EPID QC contrast tolerance (±10) and action (±20) levels using the PIPSPro phantom based around expected values of 190 (Varian 600C/D) and 225 (Varian 2100C/D) have been introduced. The dose at dmax from electronic portal imaging has been reduced

  10. Assessment of dosimetrical performance in 11 Varian a-Si500 electronic portal imaging devices

    NASA Astrophysics Data System (ADS)

    Kavuma, Awusi; Glegg, Martin; Currie, Garry; Elliott, Alex

    2008-12-01

    Dosimetrical characteristics of 11 Varian a-Si-500 electronic portal imaging devices (EPIDs) in clinical use for periods ranging between 10 and 86 months were investigated for consistency of performance and portal dosimetry implications. Properties studied include short-term reproducibility, signal linearity with monitor units, response to reference beam, signal uniformity across the detector panel, signal dependence on field size, dose-rate influence, memory effects and image profiles as a function of monitor units. The EPID measurements were also compared with those of the ionization chambers' to ensure stability of the linear accelerators. Depending on their clinical installation date, the EPIDs were interfaced with one of the two different acquisition control software packages, IAS2/IDU-II or IAS3/IDU-20. Both the EPID age and image acquisition system influenced the dosimetric characteristics with the newer version (IAS3 with IDU-20) giving better data reproducibility and linearity fit than the older version (IAS2 with IDU-II). The relative signal response (uniformity) after 50 MU was better than 95% of the central value and independent of detector. Sensitivity for all EPIDs reduced continuously with increasing dose rates for the newer image acquisition software. In the dose-rate range 100-600 MU min-1, the maximum variation in sensitivity ranged between 1 and 1.8% for different EPIDs. For memory effects, the increase in the measured signal at the centre of the irradiated field for successive images was within 1.8% and 1.0% for the older and newer acquisition systems, respectively. Image profiles acquired at a lower MU in the radial plane (gun-target) had gradients in measured pixel values of up to 25% for the older system. Detectors with software/hardware versions IAS3/IDU-20 have a high degree of accuracy and are more suitable for routine quantitative IMRT dosimetrical verification.

  11. Calculation of size specific dose estimates (SSDE) value at cylindrical phantom from CBCT Varian OBI v1.4 X-ray tube EGSnrc Monte Carlo simulation based

    NASA Astrophysics Data System (ADS)

    Nasir, M.; Pratama, D.; Anam, C.; Haryanto, F.

    2016-03-01

    The aim of this research was to calculate Size Specific Dose Estimates (SSDE) generated by the varian OBI CBCT v1.4 X-ray tube working at 100 kV using EGSnrc Monte Carlo simulations. The EGSnrc Monte Carlo code used in this simulation was divided into two parts. Phase space file data resulted by the first part simulation became an input to the second part. This research was performed with varying phantom diameters of 5 to 35 cm and varying phantom lengths of 10 to 25 cm. Dose distribution data were used to calculate SSDE values using trapezoidal rule (trapz) function in a Matlab program. SSDE obtained from this calculation was compared to that in AAPM report and experimental data. It was obtained that the normalization of SSDE value for each phantom diameter was between 1.00 and 3.19. The normalization of SSDE value for each phantom length was between 0.96 and 1.07. The statistical error in this simulation was 4.98% for varying phantom diameters and 5.20% for varying phantom lengths. This study demonstrated the accuracy of the Monte Carlo technique in simulating the dose calculation. In the future, the influence of cylindrical phantom material to SSDE would be studied.

  12. The International Permafrost Association: current initiatives for cryospheric research

    NASA Astrophysics Data System (ADS)

    Schollaen, Karina; Lewkowicz, Antoni G.; Christiansen, Hanne H.; Romanovsky, Vladimir E.; Lantuit, Hugues; Schrott, Lothar; Sergeev, Dimitry; Wei, Ma

    2015-04-01

    The International Permafrost Association (IPA), founded in 1983, has as its objectives to foster the dissemination of knowledge concerning permafrost and to promote cooperation among persons and national or international organizations engaged in scientific investigation and engineering work on permafrost. The IPA's primary responsibilities are convening International Permafrost Conferences, undertaking special projects such as preparing databases, maps, bibliographies, and glossaries, and coordinating international field programs and networks. Membership is through adhering national or multinational organizations or as individuals in countries where no Adhering Body exists. The IPA is governed by its Executive Committee and a Council consisting of representatives from 26 Adhering Bodies having interests in some aspect of theoretical, basic and applied frozen ground research, including permafrost, seasonal frost, artificial freezing and periglacial phenomena. This presentation details the IPA core products, achievements and activities as well as current projects in cryospheric research. One of the most important core products is the circumpolar permafrost map. The IPA also fosters and supports the activities of the Global Terrestrial Network on Permafrost (GTN-P) sponsored by the Global Terrestrial Observing System, GTOS, and the Global Climate Observing System, GCOS, whose long-term goal is to obtain a comprehensive view of the spatial structure, trends, and variability of changes in the active layer thickness and permafrost temperature. A further important initiative of the IPA are the biannually competitively-funded Action Groups which work towards the production of well-defined products over a period of two years. Current IPA Action Groups are working on highly topical and interdisciplinary issues, such as the development of a regional Palaeo-map of Permafrost in Eurasia, the integration of multidisciplinary knowledge about the use of thermokarst and permafrost

  13. SU-E-T-06: A Comparison of IMRT Treatment of Esophageal Carcinoma in Elekta-Precise and Varian23EX Linac

    SciTech Connect

    Bai, W; Fan, X; Qiu, R; Qiao, X; Zhang, R

    2014-06-01

    Purpose: To compare and analyze the characteristics of static intensity-modulated radiotherapy (IMRT) plans designed on Elekta and Varian Linac in different esophageal cancer(EC), exploring advantages and disadvantages of different vendor Linac, thus can be better serve for clinical. Methods: Twenty-four patients with EC were selected, including 6 cases located in the cervical, upper, middle and the lower thorax, respectively. Two IMRT plans were generated with the Oncentra planning system: in Elekta and Varian Linac, prescription dose of 60Gy in 30 fractions to the PTV. We examined the dose-volume histogram parameters of PTV and the organs at risk (OAR) such as lungs, spinal cord and heart, and additional Monitor units(MU), treatment time, Homogeneity index(HI), Conformity index(CI) and Gamma index comparisons were performed. Results: All plans resulted in abundant dose coverage of PTV for EC of different locations. The doses to PTV, HI and OAR in Elekta plans were not statistically different in comparison with Varian plans, with the following exceptions: in cervical, upper and lower thoracic EC the PTV's CI, and in middle thorax EC PTV's D2, D50, V105 and PTV-average were better in Elekta plans than in Varian plans. In the cervical, upper and the middle thorax EC, treatment time were significantly decreased in Varian plans as against Elekta plans, while in the lower thoracic EC treatment time were no striking difference. MUs and gamma index were similar between the two Linac plans. Conclusion: For the the middle thorax EC Varian plans is better than Elekta plans, not only in treatment time but in the PTV dose; while for the lower thorax EC Elekta plans is the first choice for better CI; for the other part of the EC usually Elekta plans can increase the CI, while Varian plans can reduce treatment time, can be selected according to the actual situation of the patient treatment.

  14. Ability of Kocuria varians LTH 1540 To Degrade Putrescine: Identification and Characterization of a Novel Amine Oxidase.

    PubMed

    Callejón, Sara; Sendra, Ramón; Ferrer, Sergi; Pardo, Isabel

    2015-04-29

    This work describes the identification and characterization of an amine oxidase from Kocuria varians LTH 1540 (syn. Micrococcus varians) primarily acting on putrescine. Data from MALDI-TOF MS/MS and the identification of Δ(1)-pyrroline as degradation product from putrescine indicate that the enzyme is a flavin-dependent putrescine oxidase (PuO). Properties of partially purified enzyme have been determined. The enzyme oxidizes diamines, putrescine and cadaverine, and, to a lesser extent, polyamines, such as spermidine, but not monoamines. The kinetic constants (Km and Vmax) for the two major substrates were 94 ± 10 μM and 2.3 ± 0.1 μmol/min·mg for putrescine and 75 ± 5 μM and 0.15 ± 0.02 μmol/min·mg for cadaverine. Optimal temperature and pH were 45 °C and 8.5, respectively. Enzyme was stable until 50 °C. K. varians PuO is sensitive to human flavin-dependent amine oxidase inhibitors and carboxyl-modifying compounds. The new enzyme has been isolated from a bacterial starter used in the manufacture of fermented meat. One of the problems of fermented foods or beverages is the presence of toxic biogenic amines produced by bacteria. The importance of this works lies in the description of a new enzyme able to degrade two of the most abundant biogenic amines (putrescine and cadaverine), the use of which could be envisaged to diminish biogenic amines content in foods in the future.

  15. Correlates of gut community composition across an ant species (Cephalotes varians) elucidate causes and consequences of symbiotic variability.

    PubMed

    Hu, Yi; Łukasik, Piotr; Moreau, Corrie S; Russell, Jacob A

    2014-03-01

    Insect guts are often colonized by multispecies microbial communities that play integral roles in nutrition, digestion and defence. Community composition can differ across host species with increasing dietary and genetic divergence, yet gut microbiota can also vary between conspecific hosts and across an individual's lifespan. Through exploration of such intraspecific variation and its correlates, molecular profiling of microbial communities can generate and test hypotheses on the causes and consequences of symbioses. In this study, we used 454 pyrosequencing and TRFLP to achieve these goals in an herbivorous ant, Cephalotes varians, exploring variation in bacterial communities across colonies, populations and workers reared on different diets. C. varians bacterial communities were dominated by 16 core species present in over two-thirds of the sampled colonies. Core species comprised multiple genotypes, or strains and hailed from ant-specific clades containing relatives from other Cephalotes species. Yet three were detected in environmental samples, suggesting the potential for environmental acquisition. In spite of their prevalence and long-standing relationships with Cephalotes ants, the relative abundance and genotypic composition of core species varied across colonies. Diet-induced plasticity is a likely cause, but only pollen-based diets had consistent effects, altering the abundance of two types of bacteria. Additional factors, such as host age, genetics, chance or natural selection, must therefore shape natural variation. Future studies on these possibilities and on bacterial contributions to the use of pollen, a widespread food source across Cephalotes, will be important steps in developing C. varians as a model for studying widespread social insect-bacteria symbioses.

  16. Poster — Thur Eve — 55: An automated XML technique for isocentre verification on the Varian TrueBeam

    SciTech Connect

    Asiev, Krum; Mullins, Joel; DeBlois, François; Liang, Liheng; Syme, Alasdair

    2014-08-15

    Isocentre verification tests, such as the Winston-Lutz (WL) test, have gained popularity in the recent years as techniques such as stereotactic radiosurgery/radiotherapy (SRS/SRT) treatments are more commonly performed on radiotherapy linacs. These highly conformal treatments require frequent monitoring of the geometrical accuracy of the isocentre to ensure proper radiation delivery. At our clinic, the WL test is performed by acquiring with the EPID a collection of 8 images of a WL phantom fixed on the couch for various couch/gantry angles. This set of images is later analyzed to determine the isocentre size. The current work addresses the acquisition process. A manual WL test acquisition performed by and experienced physicist takes in average 25 minutes and is prone to user manipulation errors. We have automated this acquisition on a Varian TrueBeam STx linac (Varian, Palo Alto, USA). The Varian developer mode allows the execution of custom-made XML script files to control all aspects of the linac operation. We have created an XML-WL script that cycles through each couch/gantry combinations taking an EPID image at each position. This automated acquisition is done in less than 4 minutes. The reproducibility of the method was verified by repeating the execution of the XML file 5 times. The analysis of the images showed variation of the isocenter size less than 0.1 mm along the X, Y and Z axes and compares favorably to a manual acquisition for which we typically observe variations up to 0.5 mm.

  17. Commissioning of the Varian TrueBeam linear accelerator: A multi-institutional study

    SciTech Connect

    Glide-Hurst, C.; Bellon, M.; Wen, N.; Zhao, B.; Chetty, I. J.; Foster, R.; Speiser, M.; Solberg, T.; Altunbas, C.; Westerly, D.; Miften, M.; Altman, M.

    2013-03-15

    Purpose: Latest generation linear accelerators (linacs), i.e., TrueBeam (Varian Medical Systems, Palo Alto, CA) and its stereotactic counterpart, TrueBeam STx, have several unique features, including high-dose-rate flattening-filter-free (FFF) photon modes, reengineered electron modes with new scattering foil geometries, updated imaging hardware/software, and a novel control system. An evaluation of five TrueBeam linacs at three different institutions has been performed and this work reports on the commissioning experience. Methods: Acceptance and commissioning data were analyzed for five TrueBeam linacs equipped with 120 leaf (5 mm width) MLCs at three different institutions. Dosimetric data and mechanical parameters were compared. These included measurements of photon beam profiles (6X, 6XFFF, 10X, 10XFFF, 15X), photon and electron percent depth dose (PDD) curves (6, 9, 12 MeV), relative photon output factors (Scp), electron cone factors, mechanical isocenter accuracy, MLC transmission, and dosimetric leaf gap (DLG). End-to-end testing and IMRT commissioning were also conducted. Results: Gantry/collimator isocentricity measurements were similar (0.27-0.28 mm), with overall couch/gantry/collimator values of 0.46-0.68 mm across the three institutions. Dosimetric data showed good agreement between machines. The average MLC DLGs for 6, 10, and 15 MV photons were 1.33 {+-} 0.23, 1.57 {+-} 0.24, and 1.61 {+-} 0.26 mm, respectively. 6XFFF and 10XFFF modes had average DLGs of 1.16 {+-} 0.22 and 1.44 {+-} 0.30 mm, respectively. MLC transmission showed minimal variation across the three institutions, with the standard deviation <0.2% for all linacs. Photon and electron PDDs were comparable for all energies. 6, 10, and 15 MV photon beam quality, %dd(10){sub x} varied less than 0.3% for all linacs. Output factors (Scp) and electron cone factors agreed within 0.27%, on average; largest variations were observed for small field sizes (1.2% coefficient of variation, 10 MV, 2

  18. Out-of-field doses and neutron dose equivalents for electron beams from modern Varian and Elekta linear accelerators.

    PubMed

    Cardenas, Carlos E; Nitsch, Paige L; Kudchadker, Rajat J; Howell, Rebecca M; Kry, Stephen F

    2016-01-01

    Out-of-field doses from radiotherapy can cause harmful side effects or eventually lead to secondary cancers. Scattered doses outside the applicator field, neutron source strength values, and neutron dose equivalents have not been broadly investigated for high-energy electron beams. To better understand the extent of these exposures, we measured out-of-field dose characteristics of electron applicators for high-energy electron beams on two Varian 21iXs, a Varian TrueBeam, and an Elekta Versa HD operating at various energy levels. Out-of-field dose profiles and percent depth-dose curves were measured in a Wellhofer water phantom using a Farmer ion chamber. Neutron dose was assessed using a combination of moderator buckets and gold activation foils placed on the treatment couch at various locations in the patient plane on both the Varian 21iX and Elekta Versa HD linear accelerators. Our findings showed that out-of-field electron doses were highest for the highest electron energies. These doses typically decreased with increasing distance from the field edge but showed substantial increases over some distance ranges. The Elekta linear accelerator had higher electron out-of-field doses than the Varian units examined, and the Elekta dose profiles exhibited a second dose peak about 20 to 30 cm from central-axis, which was found to be higher than typical out-of-field doses from photon beams. Electron doses decreased sharply with depth before becoming nearly constant; the dose was found to decrease to a depth of approximately E(MeV)/4 in cm. With respect to neutron dosimetry, Q values and neutron dose equivalents increased with electron beam energy. Neutron contamination from electron beams was found to be much lower than that from photon beams. Even though the neutron dose equivalent for electron beams represented a small portion of neutron doses observed under photon beams, neutron doses from electron beams may need to be considered for special cases. PMID:27455499

  19. Bioinspired artificial photonic nanoarchitecture using the elytron of the beetle Trigonophorus rothschildi varians as a ‘blueprint’

    PubMed Central

    Biró, L. P.; Kertész, K.; Horváth, E.; Márk, G. I.; Molnár, G.; Vértesy, Z.; Tsai, J.-F.; Kun, A.; Bálint, Zs.; Vigneron, J. P.

    2010-01-01

    An unusual, intercalated photonic nanoarchitecture was discovered in the elytra of Taiwanese Trigonophorus rothschildi varians beetles. It consists of a multilayer structure intercalated with a random distribution of cylindrical holes normal to the plane of the multilayer. The nanoarchitectures were characterized structurally by scanning electron microscopy and optically by normal incidence, integrated and goniometric reflectance measurements. They exhibit an unsaturated specular and saturated non-specular component of the reflected light. Bioinspired, artificial nanoarchitectures of similar structure and with similar properties were realized by drilling holes of submicron size in a multilayer structure, showing that such photonic nanoarchitectures of biological origin may constitute valuable blueprints for artificial photonic materials. PMID:19933221

  20. Monitor backscatter factors for the Varian 21EX and TrueBeam linear accelerators: measurements and Monte Carlo modelling.

    PubMed

    Zavgorodni, Sergei; Alhakeem, Eyad; Townson, Reid

    2014-02-21

    Linac backscattered radiation (BSR) into the monitor chamber affects the chamber's signal and has to be accounted for in radiotherapy dose calculations. In Monte Carlo (MC) calculations, the BSR can be modelled explicitly and accounted for in absolute dose. However, explicit modelling of the BSR becomes impossible if treatment head geometry is not available. In this study, monitor backscatter factors (MBSFs), defined as the ratio of the charge collected in the monitor chamber for a reference field to that of a given field, have been evaluated experimentally and incorporated into MC modelling of linacs with either known or unknown treatment head geometry. A telescopic technique similar to that by Kubo (1989 Med. Phys. 16 295-98) was used. However, instead of lead slits, a 1.8 mm diameter collimator and a small (2 mm diameter) detector positioned at extended source to detector distance were used. This setup provided a field of view to the source of less than 3.1 mm and allowed for MBSF measurements of open fields from 1 × 1 to 40 × 40 cm(2). For the fields with both X and Y dimensions exceeding 15 cm, a diode detector was used. A pinpoint ionization chamber was used for smaller fields. MBSFs were also explicitly modelled in MC calculations using BEAMnrc and DOSXYZnrc codes for 6 and 18 MV beams of a Varian 21EX linac. A method for deriving the D(ch)(forward) values that are used in MC absolute dose calculations was demonstrated. These values were derived from measured MBSFs for two 21EX and four TrueBeam energies. MBSFs were measured for 6 and 18 MV beams from Varian 21EX, and for 6 MV, 10 MV-FFF, 10 MV, and 15 MV beams from Varian TrueBeam linacs. For the open field sizes modelled in this study for the 21EX, the measured MBSFs agreed with MC calculated values within combined statistical (0.4%) and experimental (0.2%) uncertainties. Variation of MBSFs across field sizes was about a factor of two smaller for the TrueBeam compared to 21EX Varian linacs. Measured

  1. Monitor backscatter factors for the Varian 21EX and TrueBeam linear accelerators: measurements and Monte Carlo modelling

    NASA Astrophysics Data System (ADS)

    Zavgorodni, Sergei; Alhakeem, Eyad; Townson, Reid

    2014-02-01

    Linac backscattered radiation (BSR) into the monitor chamber affects the chamber's signal and has to be accounted for in radiotherapy dose calculations. In Monte Carlo (MC) calculations, the BSR can be modelled explicitly and accounted for in absolute dose. However, explicit modelling of the BSR becomes impossible if treatment head geometry is not available. In this study, monitor backscatter factors (MBSFs), defined as the ratio of the charge collected in the monitor chamber for a reference field to that of a given field, have been evaluated experimentally and incorporated into MC modelling of linacs with either known or unknown treatment head geometry. A telescopic technique similar to that by Kubo (1989 Med. Phys. 16 295-98) was used. However, instead of lead slits, a 1.8 mm diameter collimator and a small (2 mm diameter) detector positioned at extended source to detector distance were used. This setup provided a field of view to the source of less than 3.1 mm and allowed for MBSF measurements of open fields from 1 × 1 to 40 × 40 cm2. For the fields with both X and Y dimensions exceeding 15 cm, a diode detector was used. A pinpoint ionization chamber was used for smaller fields. MBSFs were also explicitly modelled in MC calculations using BEAMnrc and DOSXYZnrc codes for 6 and 18 MV beams of a Varian 21EX linac. A method for deriving the D_ch^forward values that are used in MC absolute dose calculations was demonstrated. These values were derived from measured MBSFs for two 21EX and four TrueBeam energies. MBSFs were measured for 6 and 18 MV beams from Varian 21EX, and for 6 MV, 10 MV-FFF, 10 MV, and 15 MV beams from Varian TrueBeam linacs. For the open field sizes modelled in this study for the 21EX, the measured MBSFs agreed with MC calculated values within combined statistical (0.4%) and experimental (0.2%) uncertainties. Variation of MBSFs across field sizes was about a factor of two smaller for the TrueBeam compared to 21EX Varian linacs. Measured MBSFs

  2. A novel sucrose hydrolase from the bombycoid silkworms Bombyx mori, Trilocha varians, and Samia cynthia ricini with a substrate specificity for sucrose.

    PubMed

    Wang, Huabing; Kiuchi, Takashi; Katsuma, Susumu; Shimada, Toru

    2015-06-01

    Although membrane-associated sucrase activity has been detected in the midgut of various lepidopteran species, it has not yet been identified and characterized at the molecular level. In the present study, we identified a novel sucrose hydrolase (SUH) gene from the following three bombycoid silkworms: Bombyx mori, Trilocha varians, and Samia cynthia ricini and named them BmSuh, TvSuh, and ScSuh, respectively. The EST dataset showed that BmSuh is one of the major glycoside hydrolase genes in the larval midgut of B. mori. These genes were almost exclusively expressed in the larval midgut in all three species, mainly at the feeding stage. SUHs are classified into the glycoside hydrolase family 13 and show significant homology to insect maltases. Enzymatic assays revealed that recombinant SUHs were distinct from conventional maltases and exhibited substrate specificity for sucrose. The recombinant BmSUH was less sensitive to sugar-mimic alkaloids than TvSUH and ScSUH, which may explain the reason why the sucrase activity in the B. mori midgut was less affected by the sugar-mimic alkaloids derived from mulberry.

  3. Association of a Biweekly Research Workgroup With Enhanced Resident Research Productivity.

    PubMed

    Brackmann, Melissa; Reynolds, R Kevin; Uppal, Shitanshu; McLean, Karen

    2016-09-01

    Almost all residency programs require a resident research project, yet teaching and mentoring of the required skills are often lacking. We established an every-other-week gynecologic oncology research workgroup at our institution for obstetrics and gynecology faculty, fellows, and residents with the goal of increasing resident research education, involvement, and productivity. An informal, discussion-style format was adopted as a forum for brainstorming research ideas, formulating study protocols, and collaborating on institutional review board submissions. Additional aims included editorial feedback on abstracts and manuscripts as well as oral presentation preparation. The academic productivity of trainees mentored by the gynecologic oncology division was queried for 27 months before and 27 months after workgroup initiation, specifically assessing resident involvement in institutional review board submission, abstract presentation, and manuscript preparation. Institution of our workgroup was associated with a dramatic increase in resident research output, including manuscript preparation and presentations at national meetings. We describe our experience because it may benefit other residency programs wishing to improve both resident research education and productivity. PMID:27500350

  4. Landfalling Tropical Cyclones: Forecast Problems and Associated Research Opportunities

    USGS Publications Warehouse

    Marks, F.D.; Shay, L.K.; Barnes, G.; Black, P.; Demaria, M.; McCaul, B.; Mounari, J.; Montgomery, M.; Powell, M.; Smith, J.D.; Tuleya, B.; Tripoli, G.; Xie, Lingtian; Zehr, R.

    1998-01-01

    The Fifth Prospectus Development Team of the U.S. Weather Research Program was charged to identify and delineate emerging research opportunities relevant to the prediction of local weather, flooding, and coastal ocean currents associated with landfalling U.S. hurricanes specifically, and tropical cyclones in general. Central to this theme are basic and applied research topics, including rapid intensity change, initialization of and parameterization in dynamical models, coupling of atmospheric and oceanic models, quantitative use of satellite information, and mobile observing strategies to acquire observations to evaluate and validate predictive models. To improve the necessary understanding of physical processes and provide the initial conditions for realistic predictions, a focused, comprehensive mobile observing system in a translating storm-coordinate system is required. Given the development of proven instrumentation and improvement of existing systems, three-dimensional atmospheric and oceanic datasets need to be acquired whenever major hurricanes threaten the United States. The spatial context of these focused three-dimensional datasets over the storm scales is provided by satellites, aircraft, expendable probes released from aircraft, and coastal (both fixed and mobile), moored, and drifting surface platforms. To take full advantage of these new observations, techniques need to be developed to objectively analyze these observations, and initialize models aimed at improving prediction of hurricane track and intensity from global-scale to mesoscale dynamical models. Multinested models allow prediction of all scales from the global, which determine long- term hurricane motion to the convective scale, which affect intensity. Development of an integrated analysis and model forecast system optimizing the use of three-dimensional observations and providing the necessary forecast skill on all relevant spatial scales is required. Detailed diagnostic analyses of these

  5. Measurement of eye lens dose for Varian On-Board Imaging with different cone-beam computed tomography acquisition techniques.

    PubMed

    Deshpande, Sudesh; Dhote, Deepak; Thakur, Kalpna; Pawar, Amol; Kumar, Rajesh; Kumar, Munish; Kulkarni, M S; Sharma, S D; Kannan, V

    2016-01-01

    The objective of this work was to measure patient eye lens dose for different cone-beam computed tomography (CBCT) acquisition protocols of Varian's On-Board Imaging (OBI) system using optically stimulated luminescence dosimeter (OSLD) and to study the variation in eye lens dose with patient geometry and distance of isocenter to the eye lens. During the experimental measurements, OSLD was placed on the patient between the eyebrows of both eyes in line of nose during CBCT image acquisition to measure eye lens doses. The eye lens dose measurements were carried out for three different cone-beam acquisition protocols (standard dose head, low-dose head [LDH], and high-quality head [HQH]) of Varian OBI. Measured doses were correlated with patient geometry and distance between isocenter and eye lens. Measured eye lens doses for standard head and HQH protocols were in the range of 1.8-3.2 mGy and 4.5-9.9 mGy, respectively. However, the measured eye lens dose for the LDH protocol was in the range of 0.3-0.7 mGy. The measured data indicate that eye lens dose to patient depends on the selected imaging protocol. It was also observed that eye lens dose does not depend on patient geometry but strongly depends on distance between eye lens and treatment field isocenter. However, undoubted advantages of imaging system should not be counterbalanced by inappropriate selection of imaging protocol, especially for very intense imaging protocol. PMID:27651564

  6. Supporting medical education research quality: the Association of American Medical Colleges' Medical Education Research Certificate program.

    PubMed

    Gruppen, Larry D; Yoder, Ernie; Frye, Ann; Perkowski, Linda C; Mavis, Brian

    2011-01-01

    The quality of the medical education research (MER) reported in the literature has been frequently criticized. Numerous reasons have been provided for these shortcomings, including the level of research training and experience of many medical school faculty. The faculty development required to improve MER can take various forms. This article describes the Medical Education Research Certificate (MERC) program, a national faculty development program that focuses exclusively on MER. Sponsored by the Association of American Medical Colleges and led by a committee of established medical education researchers from across the United States, the MERC program is built on a set of 11 interactive workshops offered at various times and places across the United States. MERC participants can customize the program by selecting six workshops from this set to fulfill requirements for certification. This article describes the history, operations, current organization, and evaluation of the program. Key elements of the program's success include alignment of program content and focus with needs identified by prospective users, flexibility in program organization and logistics to fit participant schedules, an emphasis on practical application of MER principles in the context of the participants' activities and interests, consistency in program content and format to ensure standards of quality, and a sustainable financial model. The relationship between the national MERC program and local faculty development initiatives is also described. The success of the MERC program suggests that it may be a possible model for nationally disseminated faculty development programs in other domains.

  7. Determining the factors associated with health research participation.

    PubMed

    Gucciardi, Enza; Di Liao, Chen; Cameron, Jill I

    2010-01-01

    This study explores factors and attitudes that affect willingness to participate in health research in an ambulatory population of 175 individuals. Respondents reported on their sociodemographic characteristics and rated statements on a questionnaire regarding their likelihood to participate in and attitudes toward health research. Multivariate ordinal regression analysis revealed that having more positive and less negative attitudes toward health research, access to the Internet, previous participation experience, higher education, and being Canadian-born contribute to a greater willingness to participate in health research. Understanding factors that influence research participation can help identify and direct efforts to improve research volunteer recruitment. PMID:20539155

  8. Implicit measure for yoga research: Yoga implicit association test

    PubMed Central

    Ilavarasu, Judu V; Rajesh, Sasidharan K; Hankey, Alex

    2014-01-01

    Context: The implicit association test (IAT), a new tool for yoga research is presented. Implicit measures could be used in those situations where (1) The construct is difficult to self-report, (2) there is a threat of social desirability. Clinically, we can assess cognitive dissonance by evaluating incongruence between implicit and explicit measures. Explicit preferences are self-reported. Implicit preferences are what we inherently believe, often without our conscious awareness. Aims: The primary objective of this study is to provide a bird's eye view of the field, implicit cognition, with emphasis on the IAT and the secondary objective is to illustrate through an example of our study to develop an implicit tool to assess implicit preference toward yoga. Settings and Design: A total of 5 independent samples of total 69 students undergoing short and long-term yoga courses in a Yoga University were assessed for their implicit and explicit preferences towards yoga. Materials and Methods: The yoga-IAT (Y-IAT), explicit self-rating scale was administered through computers using the Inquisit program by Millisecond Software. Experimental and scoring materials are provided. Results: A moderate preference toward yoga was detected, with a lower implicit-explicit congruence, reflecting possible confound of social desirability in the self-report of preference toward yoga. Conclusions: Implicit measures may be used in the yoga field to assess constructs, which are difficult to self-report or may have social desirability threat. Y-IAT may be used to evaluate implicit preference toward yoga. PMID:25035621

  9. Book Review: The history of the Quaternary Research Association

    NASA Astrophysics Data System (ADS)

    Bowen, D. Q.

    2016-06-01

    This is a book that should be in the library of every member of the QRA as well as their institutions. This volume is a celebration of 50 years of the Quaternary Studies Field Group (1964), which was renamed the Quaternary Research Association (QRA) in 1969. What follows is a combination of a review with some further information based on the recollection of someone who was there. In examining the origins of the QSFG due credit is paid to Richard Hey and Richard West, but an inexplicable omission is the earlier discussion between Hey, Allan Straw and others during the field meeting of the Yorkshire Geological Society in September 1962 (Worsley, 2014). It is said that history is always written by the victors, or in modern parlance by those who write the minutes! But, in the writing of history there are only degrees of unsuccess. In Chapter 2 John Catt comments on the less than perfect early archival records of the QRA. So it is to his credit that 50 years of archival material has been diligently sifted and edited. In this he was assisted by memories of some named QRA members who are thanked. Wider consultation may have filled some of the gaps. At earlier meetings it was always a pleasure to greet long retired colleagues, such as Archie Lamont at the Carlops glacial drainage system when being demonstrated by Brian Sissons in 1966, or Tony Farringdon at Ballycotton Bay in 1968, or Hallam Movius in 1971 at a London discussion meeting. Similarly, who can forget the field meeting at Canterbury in 1967 when Alec Skempton demonstrated the Sevenoaks by-pass late-glacial slope failures, and John Hutchinson's use of Pomatias elegans for dating the Folkestone Warren landslips? Jan Mangerud's first QRA meeting on the Isle of Man (1971) was notable for his prescient recognition of glaciomarine deposits.

  10. Factors Associated with Research Productivity of Agricultural Education Faculty.

    ERIC Educational Resources Information Center

    Kotrlik, Joe W.; Bartlett, James E., II; Higgins, Chadwick C.; Williams, Heather A.

    2002-01-01

    Factors influencing the research productivity of full-time agriculture professors (n=114) included the following: number of doctoral students advised to completion, self-perceptions of research confidence, and number of graduate assistant hours allocated. Not influential were percent of time on research, salary, age, gender, rank, or years in…

  11. SU-E-T-386: A Monte Carlo Dose Calculation Framework for Electron Beams On Varian TrueBeam

    SciTech Connect

    Rodrigues, A; Yin, F; Wu, Q; Sawkey, D

    2014-06-01

    Purpose: The design of the linac head is different for TrueBeam than Clinac, and there are differences in measured dose distributions in water phantoms between TrueBeam and Clinac for electron beams. Therefore, MC models for Clinac may not be applied directly to the Truebeam linac. The purpose of this study is to validate a Monte Carlo (MC) dose calculation framework for electron beams on Varian TrueBeam with phase space files provided by Varian. Methods: The particle histories from the phase space file were used as input for the down-stream simulation including jaws, applicators, and water phantom. MC packages BEAMnrc/DOSYXZnrc were used. The down-stream beam components were modeled according to manufacturer specifications and the dose distributions were compared with the measured data of standard cones. The measurements were performed in a water phantom with a p-type electron field diode (diameter 0.2cm) and ion chamber (CC13). Depth dose and orthogonal profiles at depths defined by R{sub 1} {sub 0} {sub 0}, R{sub 5} {sub 0}, Rp were compared. Results: Preliminary results for a 16 MeV phase space and 10x10, 15x15, and 20x20 cm{sup 2} applicator are presented. Simulations were run for a statistical uncertainty of <2% at depth of maximum dose for a voxel resolution of 0.5x0.5x0.2cm{sup 2}. Dose and range differences for the PDD profiles were within 2% and 1 mm, respectively. Dose differences within the central 80% of the beam width for the orthogonal profiles at depth of maximum dose were less than 2% for the 10x10, 15x15, and 20x20 cm{sup 2} applicator, respectively. Conclusion: Varian electron phase space files simulations are in agreement with measured commissioning data. These phase space files can be used in the simulation of TrueBeam linacs, and will provide reproducibility across publications. Analyses for all electron energies and standard applicators are under way and results will be included in the presentation.

  12. SU-E-T-370: Measurement of Conical Cone Output Factors for the Varian Edge Linear Accelerator

    SciTech Connect

    Li, H; Kim, J; Gordon, J; Chetty, I; Wang, S; Zhong, H; Wen, N

    2014-06-01

    Purpose: To quantify the impact of detector type, SSD/depth, and intermediate reference on conical cone output factor (OF) measurements for the Varian Edge linac. Methods: OF's for 4, 5, 7.5, 10, 12.5, 15, and 17.5 mm diameter cones relative to 10cmx10cm field were measured for the 6X FFF and 10X FFF energies, with jaws set to 5cmx5cm. Measurements were performed with an Edge diode (0.8mmx0.8mmx0.03mm WxLxT), stereotatic diode SFD, photon diode, CC01 and pinpoint chambers (2mm diameter for both). 95cm SSD/5cm depth were used in a water tank. For the measurement with diodes, OF's were cross-referred to CC13 ion chamber measurements with 3cmx3cm field, as recommended, to help mitigate the energy variation in diode response with field size. Results were compared to the representative data from Varian measured with Edge detector. With SFD, OF's at 98.5cm SSD/1.5cm depth and 90cm SSD/10cm depth were also measured. Results: OF's measured with the Edge detector matched within 1.3% (max diff) with the representative data from Varian. For the SFD, OF's matched within 1.3% for the 4, 5 and 17.5 mm cones and within 3.7% for the other cones. OF's with photon diode were within 1.3% except for the 4 and 5 mm cones where they were 8.1% and 3.7%, respectively. OF's for the CC01 and pinpoint chamber deviated up to 36% and 44%, respectively for the 4 mm cone. OF's after intermediate reference with 3cmx3cm field changed by 3.7% for SFD, 0.8% for photon diode, and 0.6% for Edge detector. OF's at 98.5cm SSD/1.5cm depth were 10.8% higher than that at 95cm SSD/5cm depth, and OF's at 90cm SSD/1.5cm depth were 7.5% lower. Conclusion: OF's measured with the Edge detector appear to be reliable. CC01 and pinpoint chambers do not appear suitable for measuring the small cone OF's. SSD/depth affects OF measurements significantly.

  13. Sea Education Association's sailing research vessels as innovative platforms for long-term research and education

    NASA Astrophysics Data System (ADS)

    Joyce, P.; Carruthers, E. A.; Engels, M.; Goodwin, D.; Lavender Law, K. L.; Lea, C.; Schell, J.; Siuda, A.; Witting, J.; Zettler, E.

    2012-12-01

    Sea Education Association's (SEA) two research vessels, the SSV Corwith Cramer and the SSV Robert C. Seamans are unique in the research world. Not only do these ships perform advanced research using state of the art equipment, they do so under sail with high school, undergraduate, and graduate students serving as both the science team and the crew. Because of SEA's educational mission and reliance on prevailing winds for sailing, the vessels have been studying repeated tracks for decades, providing valuable long-term data sets while educating future marine scientists. The Corwith Cramer has been collecting data in the North Atlantic between New England, the Sargasso Sea, Bermuda, and the Caribbean since 1987 while the Robert C. Seamans has been operating in the Eastern Pacific between the US West Coast, Hawaii, and French Polynesia since 2001. The ships collect continuous electronic data from hull mounted ADCP, chirp, and a clean flowing seawater system logging temperature, salinity, in-vivo chlorophyll and CDOM fluorescence, and beam attenuation. The ships also periodically collect data from profiling CTDs with chlorophyll and CDOM fluorometers, transmissometers, and dissolved oxygen and PAR sensors. In addition to electronic data, archived long term data sets include physical samples from net tows such as marine plastic debris and tar, and plankton including Halobates (a marine insect), leptocephali (eel larvae), and phyllosoma (spiny lobster larvae). Both vessels are 134' brigantine rig tall ships and are designated sailing school vessels (SSV) by the US Coast Guard, and both have received instrumentation grants from NSF to provide high quality, reliable data that is submitted to the NSF R2R archives. Students sailing on these ships spend time on shore at the SEA campus in Woods Hole, MA taking classes in oceanography, nautical science, maritime studies and public policy. Each student is required to write a proposal for their research before heading to sea, and

  14. SU-E-T-406: Use of TrueBeam Developer Mode and API to Increase the Efficiency and Accuracy of Commissioning Measurements for the Varian EDGE Stereotactic Linac

    SciTech Connect

    Gardner, S; Gulam, M; Song, K; Li, H; Huang, Y; Zhao, B; Qin, Y; Snyder, K; Kim, J; Gordon, J; Chetty, I; Wen, N

    2014-06-01

    hours). The scripting also allowed for creation of the files in advance without requiring access to TPS. The API scripting functionality enabled efficient creation/mining of TPS data. Finally, automation reduces the potential for human error in entering linac values at the machine console,and the script provides a log of measurements acquired for each session. This research was supported in part by a grant from Varian Medical Systems, Palo Alto, CA.

  15. Bioconcentration of the anionic surfactant linear alkylbenzene sulfonate (LAS) in the marine shrimp Palaemonetes varians: a radiotracer study.

    PubMed

    Renaud, Florent; Warnau, Michel; Oberhänsli, François; Teyssié, Jean-Louis; Temara, Ali; Rouleau, Claude; Metian, Marc

    2014-08-15

    Uptake and depuration kinetics of dissolved [(14)C]C₁₂-6-linear alkylbenzene sulfonate (LAS) were determined in the shrimp Palaemonetes varians using environmentally relevant exposure concentration. The shrimp concentrated LAS from seawater with a mean BCF value of 120 L kg(-1) after a 7-day exposure. Uptake biokinetics were best described by a saturation model, with an estimated BCFss, of 159 ± 34 L kg(-1), reached after 11.5 days. Shrimp weight influenced significantly BCF value with smaller individuals presenting higher affinity to LAS. To the light of a whole body autoradiography, major accumulation of LAS occurred in the cephalothorax circulatory system (gills, heart, hepatopancreas) and ocular peduncle, but not in the flesh, limiting potential transfer to human consumers. LAS depuration rate constant value of the shrimp was 1.18 ± 0.08 d(-1) leading to less than 1% of remaining LAS in its tissues after 8 days of depuration.

  16. Characterization of the radiation environment at the UNLV accelerator facility during operation of the Varian M6 linac

    NASA Astrophysics Data System (ADS)

    Hodges, M.; Barzilov, A.; Chen, Y.; Lowe, D.

    2016-10-01

    The bremsstrahlung photon flux from the UNLV particle accelerator (Varian M6 model) was determined using MCNP5 code for 3 MeV and 6 MeV incident electrons. Human biological equivalent dose rates due to accelerator operation were evaluated using the photon flux with the flux-to-dose conversion factors. Dose rates were computed for the accelerator facility for M6 linac use under different operating conditions. The results showed that the use of collimators and linac internal shielding significantly reduced the dose rates throughout the facility. It was shown that the walls of the facility, in addition to the earthen berm enveloping the building, provide equivalent shielding to reduce dose rates outside to below the 2 mrem/h limit.

  17. Female sex pheromone and male behavioral responses of the bombycid moth Trilocha varians: comparison with those of the domesticated silkmoth Bombyx mori

    NASA Astrophysics Data System (ADS)

    Daimon, Takaaki; Fujii, Takeshi; Yago, Masaya; Hsu, Yu-Feng; Nakajima, Yumiko; Fujii, Tsuguru; Katsuma, Susumu; Ishikawa, Yukio; Shimada, Toru

    2012-03-01

    Analysis of female sex pheromone components and subsequent field trap experiments demonstrated that the bombycid moth Trilocha varians uses a mixture of ( E, Z)-10,12-hexadecadienal (bombykal) and ( E,Z)-10,12-hexadecadienyl acetate (bombykyl acetate) as a sex pheromone. Both of these components are derivatives of ( E,Z)-10,12-hexadecadienol (bombykol), the sex pheromone of the domesticated silkmoth Bombyx mori. This finding prompted us to compare the antennal and behavioral responses of T. varians and B. mori to bombykol, bombykal, and bombykyl acetate in detail. The antennae of T. varians males responded to bombykal and bombykyl acetate but not to bombykol, and males were attracted only when lures contained both bombykal and bombykyl acetate. In contrast, the antennae of B. mori males responded to all the three components. Behavioral analysis showed that B. mori males responded to neither bombykal nor bombykyl acetate. Meanwhile, the wing fluttering response of B. mori males to bombykol was strongly inhibited by bombykal and bombykyl acetate, thereby indicating that bombykal and bombykyl acetate act as behavioral antagonists for B. mori males. T. varians would serve as a reference species for B. mori in future investigations into the molecular mechanisms underlying the evolution of sex pheromone communication systems in bombycid moths.

  18. Measurement of eye lens dose for Varian On-Board Imaging with different cone-beam computed tomography acquisition techniques

    PubMed Central

    Deshpande, Sudesh; Dhote, Deepak; Thakur, Kalpna; Pawar, Amol; Kumar, Rajesh; Kumar, Munish; Kulkarni, M. S.; Sharma, S. D.; Kannan, V.

    2016-01-01

    The objective of this work was to measure patient eye lens dose for different cone-beam computed tomography (CBCT) acquisition protocols of Varian's On-Board Imaging (OBI) system using optically stimulated luminescence dosimeter (OSLD) and to study the variation in eye lens dose with patient geometry and distance of isocenter to the eye lens. During the experimental measurements, OSLD was placed on the patient between the eyebrows of both eyes in line of nose during CBCT image acquisition to measure eye lens doses. The eye lens dose measurements were carried out for three different cone-beam acquisition protocols (standard dose head, low-dose head [LDH], and high-quality head [HQH]) of Varian OBI. Measured doses were correlated with patient geometry and distance between isocenter and eye lens. Measured eye lens doses for standard head and HQH protocols were in the range of 1.8–3.2 mGy and 4.5–9.9 mGy, respectively. However, the measured eye lens dose for the LDH protocol was in the range of 0.3–0.7 mGy. The measured data indicate that eye lens dose to patient depends on the selected imaging protocol. It was also observed that eye lens dose does not depend on patient geometry but strongly depends on distance between eye lens and treatment field isocenter. However, undoubted advantages of imaging system should not be counterbalanced by inappropriate selection of imaging protocol, especially for very intense imaging protocol. PMID:27651564

  19. Efficacy evaluation of retrospectively applying the Varian normal breathing predictive filter for volume definition and artifact reduction in 4D CT lung patients.

    PubMed

    Malone, Ciaran; Rock, Luke; Skourou, Christina

    2014-05-08

    Phase-based sorting of four-dimensional computed tomography (4D CT) datasets is prone to image artifacts due to patient's breathing irregularities that occur during the image acquisition. The purpose of this study is to investigate the effect of the Varian normal breathing predictive filter (NBPF) as a retrospective phase-sorting parameter in 4D CT. Ten 4D CT lung cancer datasets were obtained. The volumes of all tumors present, as well as the total lung volume, were calculated on the maximum intensity projection (MIP) images as well as each individual phase image. The NBPF was varied retrospectively within the available range, and changes in volume and image quality were recorded. The patients' breathing trace was analysed and the magnitude and location of any breathing irregularities were correlated to the behavior of the NBPF. The NBPF was found to have a considerable effect on the quality of the images in MIP and single-phase datasets. When used appropriately, the NBPF is shown to have the ability to account for and correct image artifacts. However, when turned off (0%) or set above a critical level (approximately 40%), it resulted in erroneous volume reconstructions with variations in tumor volume up to 26.6%. Those phases associated with peak inspiration were found to be more susceptible to changes in the NBPF. The NBPF settings selected prior to exporting the breathing trace for patients evaluated using 4D CT directly affect the accuracy of the targeting and volume estimation of lung tumors. Recommendations are made to address potential errors in patient anatomy introduced by breathing irregularities, specifically deep breath or cough irregularities, by implementing the proper settings and use of this tool.

  20. Faculty Research Productivity: Some Moderators of Associated Stressors.

    ERIC Educational Resources Information Center

    Blackburn, Robert T.; Bently, Richard J.

    1993-01-01

    A study with 894 college faculty investigated the effects of certain stress variables on different kinds of faculty research activity; psychological and organizational variables thought to moderate stress; and the effects of stressors and moderators for gender, institution type, and discipline (humanities, social sciences, natural sciences)…

  1. Weak associations in epidemiological research: some examples and their interpretation.

    PubMed

    Florey, C D

    1988-12-01

    The study of the epidemiology of chronic non-infectious diseases grew rapidly after the Second World War. In the early 1950s strong associations were found in studies based on hypotheses derived from clinical, demographic and animal observations. The associations between smoking and lung cancer, physical exercise and myocardial infarction, and air pollution and mortality all led to more than three decades of epidemiological endeavour to refine our understanding of the initial observations. As the large effects were discovered, new associations were perforce of smaller magnitude. The benefits of milk supplements to the diet of school-age children was elegantly shown in an MRC trial in 1920s using small numbers of deprived children, whereas in the 1970s, when the population's nutrition was vastly improved, many thousands of children were needed to give an answer. The impact of passive smoking on cancer incidence, on children's health and on pregnancy is a current debate because of the vanishingly small effects. Studies of the relation between alcohol consumption during pregnancy and the outcome of pregnancy has given rise to conflicting findings so that clear cut scientifically based recommendations cannot be given to social drinkers. The demands of governments for epidemiological evidence on which to base standards for pollutants in the air, water and ground, has resulted in the need for multiple studies using different techniques to suggest whether or not an association between health and exposure exists. These examples are used to illustrate the difficulties of interpretation of epidemiological studies when the effects of suspected risk factors are small.

  2. Defining Educational Research: A Perspective of/on Presidential Addresses and the Australian Association for Research in Education

    ERIC Educational Resources Information Center

    Lingard, Bob; Gale, Trevor

    2010-01-01

    This paper is concerned with the definition of the field of educational research and the changing and developing role of the Australian Association for Research in Education (AARE) in representing and constituting this field. The evidence for the argument is derived from AARE Presidential Addresses across its 40-year history. The paper documents…

  3. Alternative Research Perspectives on the Effects of School Organization and Social Contexts. An American Education Research Association Symposium.

    ERIC Educational Resources Information Center

    McPartland, James M.; McDill, Edward L.

    This report was prepared as part of the School Organization Program, a program focusing on authority-control structures, task structures, reward systems, and peer group processes in schools. It contains five papers delivered at an American Education Research Association Symposium. The papers examine current research on the effects of school…

  4. A Retrospective Appraisal of 15 Years' Proceedings of the Hungarian Research Student Association

    ERIC Educational Resources Information Center

    Revesz, Tamas; Olah, Mate

    2013-01-01

    In 1996 the Hungarian Research Student Association (HRSA) was founded. Since then more than 6000 young, talented researchers have belonged to the Association. The founders set two principal aims: (1) to support the gifted and the most promising high school students and (2) to establish an active community. The movement has grown through the work…

  5. A Monte Carlo simulation framework for electron beam dose calculations using Varian phase space files for TrueBeam Linacs

    SciTech Connect

    Rodrigues, Anna; Yin, Fang-Fang; Wu, Qiuwen; Sawkey, Daren

    2015-05-15

    Purpose: To develop a framework for accurate electron Monte Carlo dose calculation. In this study, comprehensive validations of vendor provided electron beam phase space files for Varian TrueBeam Linacs against measurement data are presented. Methods: In this framework, the Monte Carlo generated phase space files were provided by the vendor and used as input to the downstream plan-specific simulations including jaws, electron applicators, and water phantom computed in the EGSnrc environment. The phase space files were generated based on open field commissioning data. A subset of electron energies of 6, 9, 12, 16, and 20 MeV and open and collimated field sizes 3 × 3, 4 × 4, 5 × 5, 6 × 6, 10 × 10, 15 × 15, 20 × 20, and 25 × 25 cm{sup 2} were evaluated. Measurements acquired with a CC13 cylindrical ionization chamber and electron diode detector and simulations from this framework were compared for a water phantom geometry. The evaluation metrics include percent depth dose, orthogonal and diagonal profiles at depths R{sub 100}, R{sub 50}, R{sub p}, and R{sub p+} for standard and extended source-to-surface distances (SSD), as well as cone and cut-out output factors. Results: Agreement for the percent depth dose and orthogonal profiles between measurement and Monte Carlo was generally within 2% or 1 mm. The largest discrepancies were observed within depths of 5 mm from phantom surface. Differences in field size, penumbra, and flatness for the orthogonal profiles at depths R{sub 100}, R{sub 50}, and R{sub p} were within 1 mm, 1 mm, and 2%, respectively. Orthogonal profiles at SSDs of 100 and 120 cm showed the same level of agreement. Cone and cut-out output factors agreed well with maximum differences within 2.5% for 6 MeV and 1% for all other energies. Cone output factors at extended SSDs of 105, 110, 115, and 120 cm exhibited similar levels of agreement. Conclusions: We have presented a Monte Carlo simulation framework for electron beam dose calculations for

  6. Relationships between Association of Research Libraries (ARL) Statistics and Bibliometric Indicators: A Principal Components Analysis

    ERIC Educational Resources Information Center

    Hendrix, Dean

    2010-01-01

    This study analyzed 2005-2006 Web of Science bibliometric data from institutions belonging to the Association of Research Libraries (ARL) and corresponding ARL statistics to find any associations between indicators from the two data sets. Principal components analysis on 36 variables from 103 universities revealed obvious associations between…

  7. 76 FR 23537 - Hass Avocado Promotion, Research, and Information Order; Importer Associations and Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... Agricultural Marketing Service Hass Avocado Promotion, Research, and Information Order; Importer Associations... announces an updated computation for assessments received by importer associations under the Hass Avocado... consumption of Hass avocados in the United States. A state association receives 85 percent of the...

  8. Exploring Ethical Issues Associated with Using Online Surveys in Educational Research

    ERIC Educational Resources Information Center

    Roberts, Lynne D.; Allen, Peter J.

    2015-01-01

    Online surveys are increasingly used in educational research, yet little attention has focused on ethical issues associated with their use in educational settings. Here, we draw on the broader literature to discuss 5 key ethical issues in the context of educational survey research: dual teacher/researcher roles; informed consent; use of…

  9. Mid-South Educational Research Association Proceedings (21st, Knoxville, Tennessee, November 11-13, 1992).

    ERIC Educational Resources Information Center

    Petry, John R., Ed.; And Others

    The Mid-South Educational Research Association is a non-profit organization that exists to encourage quality educational research in the mid-south and to promote the applications of such research in the schools. These proceedings contain abstracts of the discussion sessions, display sessions, symposia, and training sessions of the 1992 annual…

  10. AERA Code of Ethics: American Educational Research Association Approved by the AERA Council February 2011

    ERIC Educational Resources Information Center

    Educational Researcher, 2011

    2011-01-01

    The Code of Ethics of the American Educational Research Association (AERA) articulates a common set of values upon which education researchers build their professional and scientific work. The Code is intended to provide both the principles and the rules to cover professional situations encountered by education researchers. It has as its primary…

  11. First reported fatalities associated with the 'research chemical' 2-methoxydiphenidine.

    PubMed

    Elliott, Simon P; Brandt, Simon D; Wallach, Jason; Morris, Hamilton; Kavanagh, Pierce V

    2015-05-01

    2-Methoxydiphenidine, i.e. 1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine, also known as 'MXP' or '2-MeO-diphenidine' (or 2-MXP), has been available as a 'research chemical' since 2013 as a purported alternative to the 'dissociative anesthetics' methoxetamine and ketamine. Three deaths which involved the detection of 2-MXP in post-mortem blood and urine were encountered in forensic casework. The 2-, 3- and 4-methoxyphenyl positional isomers were synthesized to confirm the identity and concentration of 2-MXP. The 2-MXP femoral blood concentrations in the cases were found to be 24.0, 2.0 and 1.36 mg/L (the latter with an alternative cause of death). Some additional prescription drugs were encountered at therapeutic concentrations in all three cases. Analysis of the biofluids allowed the detection and characterization of various metabolites, including the suggested presence of hydroxy-2-MXP as the main metabolite with the hydroxyl group located on the piperidine rather than the phenyl or benzyl moiety. Additional metabolites included O-desmethyl-2-MXP and hydroxylated O-desmethyl-2-MXP. Diphenidine and hydroxy-diphenidine, also showing the presence of the hydroxyl group on the piperidine ring, were also detected. It was not possible to identify whether these arose from 2-MXP biotransformation or whether they represented the presence of diphenidine as a separate substance. These are the first published fatalities involving 2-MXP and presents analytical data to assist analytical toxicologists with future casework.

  12. The potential for climate-driven bathymetric range shifts: sustained temperature and pressure exposures on a marine ectotherm, Palaemonetes varians

    PubMed Central

    Morris, J. P.; Thatje, S.; Cottin, D.; Oliphant, A.; Brown, A.; Shillito, B.; Ravaux, J.; Hauton, C.

    2015-01-01

    Range shifts are of great importance as a response for species facing climate change. In the light of current ocean-surface warming, many studies have focused on the capacity of marine ectotherms to shift their ranges latitudinally. Bathymetric range shifts offer an important alternative, and may be the sole option for species already at high latitudes or those within enclosed seas; yet relevant data are scant. Hydrostatic pressure (HP) and temperature have wide ranging effects on physiology, importantly acting in synergy thermodynamically, and therefore represent key environmental constraints to bathymetric migration. We present data on transcriptional regulation in a shallow-water marine crustacean (Palaemonetes varians) at atmospheric and high HP following 168-h exposures at three temperatures across the organisms’ thermal scope, to establish the potential physiological limit to bathymetric migration by neritic fauna. We observe changes in gene expression indicative of cellular macromolecular damage, disturbances in metabolic pathways and a lack of acclimation after prolonged exposure to high HP. Importantly, these effects are ameliorated (less deleterious) at higher temperatures, and exacerbated at lower temperatures. These data, alongside previously published behavioural and heat-shock analyses, have important implications for our understanding of the potential for climate-driven bathymetric range shifts PMID:26716003

  13. Effect of magnesium and some nutrients on the growth and nuclease formation of a moderate halophile, Micrococcus varians var. halophilus.

    PubMed

    Kamekura, M; Onishi, H

    1976-10-01

    Production of halophilic nuclease by a moderate halophile, Micrococcus varians, ATCC 21971, was maximal at 2.5 to 3.5 M NaCl concentration in a complex medium (CM) composed of 1% casamino acids, 1% yeast extract, and NaCl. The addition of 81 mM MgSO4 to CM inhibited nuclease production in spite of good growth. Microscopic observation showed that this inhibition was accompanied by complete clumping of the cells. The Sehgal and Gibbons complex medium (SGC) which contained 0.75% vitamin-free casamino acids, 1% yeast extract, and NaCl, however, supported good production of the nuclease in spite of the presence of 81 mM MgSO4. It seemed that both magnesium sulfate and some substances present in CM might be responsible for this inhibition and clumping. A synthetic medium optimal for enzyme production was developed consisting of 16 amino acids, 4 vitamins, 0.73 mM KH2PO4, 2.7 mM KCl, 20 mM MgSO4, and 2.5 M NaCl. The organism required biotin as an essential growth factor, and thiamine, riboflavin, and choline as stimulating factors. Omission of isoleucine from the medium reduced markedly the growth rate. Glutamic acid, proline, and arginine were consumed completely during cultivation in the synthetic medium.

  14. Improvement of Varian a-Si EPID dosimetry measurements using a lead-shielded support-arm

    SciTech Connect

    Rowshanfarzad, Pejman; Sabet, Mahsheed; O'Connor, Daryl J.; Greer, Peter B.

    2012-07-01

    Dosimetry measurements with Varian amorphous silicon electronic portal imaging devices (a-Si EPIDs) are affected by the backscattered radiation from the EPID support arm. In this study, the nonuniform backscatter from an E-type support arm was reduced by fixing a thick (12.2 Multiplication-Sign 10.5 Multiplication-Sign 0.5 cm{sup 3}) piece of lead on top of the arm, and the remaining backscatter was modeled and included in an existing dose prediction algorithm. The applied backscatter kernel was the average of kernels on different regions of the EPID over the arm. The lead-shielded arm reduced the nonuniform backscatter component by about 50% for field sizes ranging from 3 Multiplication-Sign 3 to 30 Multiplication-Sign 30 cm{sup 2} and the field symmetry improved for medium to large fields up to 3%. Gamma evaluation of the measured and modeled doses (2%, 2-mm criteria) showed that using the lead-shielded arm in the model increased the number of points with Gamma index <1 by 5.7% and decreased the mean Gamma by 0.201. Even using the lead alone (no modeling) could increase the number of points with Gamma index <1 by 4.7% and decrease the mean Gamma by 0.153. This is a simple and easy method to decrease the nonuniform arm backscatter and improve the accuracy of dosimetry measurements with the existing EPIDs used for clinical applications.

  15. Varian 2100C/D Clinac 18 MV photon phase space file characterization and modeling by using MCNP Code

    NASA Astrophysics Data System (ADS)

    Ezzati, Ahad Ollah

    2015-07-01

    Multiple points and a spatial mesh based surface source model (MPSMBSS) was generated for 18MV Varian 2100 C/D Clinac phase space file (PSF) and implemented in MCNP code. The generated source model (SM) was benchmarked against PSF and measurements. PDDs and profiles were calculated using the SM and original PSF for different field sizes from 5 × 5 to 20 × 20 cm2. Agreement was within 2% of the maximum dose at 100cm SSD for beam profiles at the depths of 4cm and 15cm with respect to the original PSF. Differences between measured and calculated points were less than 2% of the maximum dose or 2mm distance to agreement (DTA) at 100 cm SSD. Thus it can be concluded that the modified MCNP code can be used for radiotherapy calculations including multiple source model (MSM) and using the source biasing capability of MPSMBSS can increase the simulation speed up to 3600 for field sizes smaller than 5 × 5 cm2.

  16. SU-E-T-403: Measurement of the Neutron Ambient Dose Equivalent From the TrueBeam Linac Head and Varian 2100 Clinac

    SciTech Connect

    Harvey, M; Pollard, J; Wen, Z; Gao, S

    2014-06-01

    Purpose: High-energy x-ray therapy produces an undesirable source of stray neutron dose to healthy tissues, and thus, poses a risk for second cancer induction years after the primary treatment. Hence, the purpose of this study was to measure the neutron ambient dose equivalent, H*(10), produced from the TrueBeam and Varian 2100 linac heads, respectively. Of particular note is that there is no measured data available in the literature on H*(10) production from the TrueBeam treatment head. Methods: Both linacs were operated in flattening filter mode using a 15 MV x-ray beam on TrueBeam and an 18 MV x-ray beam for the Varian 2100 Clinac with the jaws and multileaf collimators in the fully closed position. A dose delivery rate of 600 MU/min was delivered on the TrueBeam and the Varian 2100 Clinac, respectively and the H*(10) rate was measured in triplicate using the WENDI-2 detector located at multiple positions including isocenter and longitudinal (gun-target) to the isocenter. Results: For each measurement, the H*(10) rate was relatively constant with increasing distance away from the isocenter with standard deviations on the order of a tenth of a mSv/h or less for the given beam energy. In general, fluctuations in the longitudinal H*(10) rate between the anterior-posterior couch directions were approximately a percent for both beam energies. Conclusion: Our preliminary results suggest an H*(10) rate of about 30 mSv/h (40 mSv/h) or less for TrueBeam (Varian Clinac 2100) for all measurements considered in this study indicating a relatively low contribution of produced secondary neutrons to the primary therapeutic beam.

  17. Transforming Catholic Education through Research: The American Educational Research Association Catholic Education Special Interest Group

    ERIC Educational Resources Information Center

    Martin, Shane

    2014-01-01

    Catholic schools in the United States and abroad face numerous financial, cultural, and structural challenges due to contemporary education policies and economic trends. Within this climate, research about Catholic education is often conducted and leveraged in efforts to serve schools' most immediate needs. To be certain, research aimed at…

  18. Becoming a Researcher: Forms of Capital Associated with "Research Capacity" Trajectories of Young British Social Anthropologists

    ERIC Educational Resources Information Center

    Holligan, Chris

    2015-01-01

    The paper privileges the "voices" of British social anthropologists examining their perceptions of how their research expertise was acquired. Reference is made to the case of education research in Britain, which, by comparison with social anthropology, reveals limited capacity as measured through performance audits of scientific research…

  19. Integrating Human Resources and Technology. Proceedings of the Association for Institutional Research Forum (Toronto, Canada, May 23-26, 1983). Association for Institutional Research 1983-1984 Directory.

    ERIC Educational Resources Information Center

    Coleman, Daniel R., Ed.

    Abstracts and four papers from the 1983 Association for Institutional Research (AIR) Forum on integrating human resources and technology are presented. AIR membership and organizational information are also provided. Paper titles and authors are as follows: "It Ain't All Bad" (Dean F. Berkley); "Technological Innovation and Strategies for…

  20. SU-F-BRE-10: Methods to Simulate and Measure the Attenuation for Modeling a Couch Top with Rails for FFF Treatment Delivery On the Varian Edge Linac

    SciTech Connect

    Gulam, M; Gardner, S; Zhao, B; Snyder, K; Song, K; Li, H; Gordon, J; Wen, N; Chetty, I; Kearns, W

    2014-06-15

    Purpose: To measure attenuation for modelling of the KVue Couchtop for 6X and 10X FFF SRS/SBRT treatment Methods: Treatment planning simulation studies were done using 6X FFF beams to estimate the dosimetric impact of KVue couchtops (including the Q-Fix IGRT [carbon fiber] and Calypso [nonconductive Kevlar material]) with a structure model obtained from a research workstation (Eclipse, advanced planning interface (API) v13). Prior to installation on the Varian Edge linac, the couchtop along with (Kevlar) rails were CT scanned with the rails at various positions. An additional scan with the couchtop 15cm above the CT table top was obtained with 20cm solid water to facilitate precised/indexed data acquisition. Measurements for attenuation were obtained for field sizes of 2, 4 and 10 cm{sup 2} at 42 gantry angles including 6 pairs of opposing fields and other angles for oblique delivery where the beams traversed the couchtop and or rails. The delivery was fully automated with xml scripts running in developer mode. The results were then used to determine an accurate structure model for AAA (Eclipse v11) planning of IMRT and RapidArc delivery. Results: The planning simulation relative dose attenuation for oblique entry was not significantly different than the Exact IGRT or BrainLab iBeam couch except that the rails added 6% additional attenuation. The relative attenuation measurements for PA, PA (rails: inner position), oblique, oblique (rails: outer position), oblique (rails: inner position) were: −2.0%, −2.5%, −15.6%, −2.5%, −5.0% for 6X FFF and −1.4%, −1.5%, −12.2%, − 2.5%, −5.0% for 10X FFF with slight decrease in attenuation versus field size. A Couch structure model (with HU values) was developed. Calculation compared to measurement showed good agreement except for oblique (rails: outer position) where differences approached a magnitude of 6%. Conclusion: A model of the couch structures has been developed accounting for attenuation for FFF

  1. 78 FR 20664 - Society of Clinical Research Associates-Food and Drug Administration: Food and Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... Administration: Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good... Society of Clinical Research Associates (SOCRA). The conference on FDA's clinical trial requirements is... relationships among FDA and clinical trial staff, investigators, and institutional review boards...

  2. Self-Regulation of a Chiropractic Association through Participatory Action Research

    ERIC Educational Resources Information Center

    Sheppard, Lorraine A.; Jorgensen, Anna Maria S.; Crowe, Michael J.

    2012-01-01

    Participatory action research (PAR) can be used in the health professions to redefine their roles. This study investigated a small health professional group, the members of The Chiropractic Association Singapore (TCAS), by using a PAR method; researchers and participants gained insights into the self-regulation of a health profession. A…

  3. Longitudinal Associations among Undergraduates' Research Experience, Self-Efficacy, and Identity

    ERIC Educational Resources Information Center

    Robnett, Rachael D.; Chemers, Martin M.; Zurbriggen, Eileen L.

    2015-01-01

    Prior research shows that undergraduates tend to identify more strongly with the field of science after participating in scientific research. However, mediators that might account for this association are not well understood. In the current study, we propose that science self-efficacy may serve this mediational function. Specifically, data from a…

  4. American Vocational Education Research Association (AVERA) Proceedings (New Orleans, Louisiana, December 10-13, 1998).

    ERIC Educational Resources Information Center

    American Vocational Education Research Association.

    This document contains 14 research paper presentations and 5 "mini-tips" from the 1998 American Vocational Education Research Association (AVERA) annual meeting. The first section includes three papers on international and distance education: "Determining Success of Vocational Students Enrolled in Distance Education Courses" (Michael K. Swan,…

  5. Lysinibacillus varians sp. nov., an endospore-forming bacterium with a filament-to-rod cell cycle.

    PubMed

    Zhu, Chunjie; Sun, Guoping; Chen, Xingjuan; Guo, Jun; Xu, Meiying

    2014-11-01

    Six Gram-stain-positive, motile, filamentous and/or rod-shaped, spherical spore-forming bacteria (strains GY32(T), L31, F01, F03, F06 and F07) showing polybrominated diphenyl ether transformation were investigated to determine their taxonomic status. After spore germination, these organisms could grow more than one hundred microns long as intact single cells and then divide into rod cells and form endospores in 33 h. The cell-wall peptidoglycan of these strains was type A4α, the predominant menaquinone was MK-7 and the major fatty acids were iso-C(16:0), iso-C(15:0) and C(16:1)ω7C. Diphosphatidylglycerol, phosphatidylglycerol and phosphatidylethanolamine were detected in the polar lipid profile. Analysis of the 16S rRNA gene sequences indicated that these strains should be placed in the genus Lysinibacillus and they were most closely related to Lysinibacillus sphaericus DSM 28(T) (99% 16S rRNA gene sequence similarity). The gyrB sequence similarity and DNA-DNA relatedness between strain GY32(T) and L. sphaericus JCM 2502(T) were 81% and 52%, respectively. The G+C content of the genomic DNA of strain GY32(T) was 43.2 mol%. In addition, strain GY32(T) showed differences in nitrate reduction, starch and gelatin hydrolysis, carbon resource utilization and cell morphology. The phylogenetic distance from its closest relative measured by DNA-DNA relatedness and DNA G+C content, and its phenotypic properties demonstrated that strain GY32(T) represents a novel species of the genus Lysinibacillus, for which the name Lysinibacillus varians sp. nov. is proposed. The type strain is GY32(T) ( = NBRC 109424(T) = CGMCC 1.12212(T) = CCTCC M 2011307(T)).

  6. Personality Traits Are Associated with Research Misbehavior in Dutch Scientists: A Cross-Sectional Study

    PubMed Central

    Tijdink, Joeri K.; Bouter, Lex M.; Veldkamp, Coosje L. S.; van de Ven, Peter M.; Wicherts, Jelte M.; Smulders, Yvo M.

    2016-01-01

    Background Personality influences decision making and ethical considerations. Its influence on the occurrence of research misbehavior has never been studied. This study aims to determine the association between personality traits and self-reported questionable research practices and research misconduct. We hypothesized that narcissistic, Machiavellianistic and psychopathic traits as well as self-esteem are associated with research misbehavior. Methods Included in this cross-sectional study design were 535 Dutch biomedical scientists (response rate 65%) from all hierarchical layers of 4 university medical centers in the Netherlands. We used validated personality questionnaires such as the Dark Triad (narcissism, psychopathy, and Machiavellianism), Rosenberg's Self-Esteem Scale, the Publication Pressure Questionnaire (PPQ), and also demographic and job-specific characteristics to investigate the association of personality traits with a composite research misbehavior severity score. Findings Machiavellianism was positively associated (beta 1.28, CI 1.06–1.53) with self-reported research misbehavior, while narcissism, psychopathy and self-esteem were not. Exploratory analysis revealed that narcissism and research misconduct were more severe among persons in higher academic ranks (i.e., professors) (p<0.01 and p<0.001, respectively), and self-esteem scores and publication pressure were lower (p<0.001 and p<0.01, respectively) as compared to postgraduate PhD fellows. Conclusions Machiavellianism may be a risk factor for research misbehaviour. Narcissism and research misbehaviour were more prevalent among biomedical scientists in higher academic positions. These results suggest that personality has an impact on research behavior and should be taken into account in fostering responsible conduct of research. PMID:27684371

  7. The Ninth Annual American Association for Cancer Research International Conference on Frontiers in Cancer Prevention Research

    PubMed Central

    Xu, Li; Wang, Sophia S.; Healey, Megan A.; Faupel-Badger, Jessica M.; Wilken, Jason A.; Battaglia, Tracy; Szabo, Eva; Mao, Jenny T.; Bergan, Raymond C.

    2016-01-01

    The Ninth Annual AACR Frontiers in Cancer Prevention Research conference was held in Philadelphia in November 7–10, 2010. Its thematic focus was “Prevention: From Basic Science to Public Health Benefit.” Telomere plasticity, the microenvironment, inflammation, transformation to the metastatic phenotype, and pathways to obesity were highlighted as important elements of carcinogenesis amenable to intervention. The integration of information from novel technologies related to physical biology, molecular and genetic profiles, and imaging along with behavioral and clinical parameters have advanced risk stratification and early detection. Cancer prevention represents a powerful testing ground for the development of individually tailored intervention and for increasing the efficiency of drug discovery. Advances in clinical trials relate to more efficient design strategies, have shown first-in-human targeting capabilities, and have developed powerful strategies to overcome accrual barriers. Tailored intervention strategies now show high efficacy on large cohorts across several cancer types. These successes are expected to increase. PMID:21464034

  8. NASA Space Biology Research Associate Program for the 21st Century

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, Gerald

    1999-01-01

    The Space Biology Research Associate Program for the 21st Century provided a unique opportunity to train individuals to conduct biological research in hypo- and hyper-gravity, and to conduct ground-based research. This grant was developed to maximize the potential for Space Biology as an emerging discipline and to train a cadre of space biologists. The field of gravitational and space biology is rapidly growing at the future of the field is reflected in the quality and education of its personnel. Our chief objective was to train and develop these scientists rapidly and in a cost effective manner. The program began on June 1, 1980 with funding to support several Research Associates each year. 113 awards, plus 1 from an independently supported minority component were made for the Research Associates program. The program was changed from a one year award with a possibility for renewal to a two year award. In 1999, the decision was made by NASA to discontinue the program due to development of new priorities for funding. This grant was discontinued because of the move of the Program Director to a new institution; a new grant was provided to that new institution to allow completion of the training of the remaining 2 research associates in 1999. After 1999, the program will be discontinued.

  9. Unpacking capacity to utilize research: A tale of the Burkina Faso public health association.

    PubMed

    Hamel, Nadia; Schrecker, Ted

    2011-01-01

    One of the most important challenges in addressing global health is for institutions to monitor and use research in policy-making. In low- and middle-income countries (LMICs), civil society organizations such as health professional associations can be key contributors to effective national health systems. However, there is little empirical data on their capacity to use research. This case study was used to gain insight into the factors that affect the knowledge translation performance of health professional associations in LMICs by describing the organizational elements and processes constituting capacity to use research, and examining the potential determinants of this capacity. Case study methodology was chosen for its flexibility to capture the multiple and often tacit processes within organizational routines. The Burkina Faso Public Health Association (ABSP) was studied, using in-depth, semi-structured interviews and key documents review. Five key dimensions that affect the association's capacity to use research to influence health policy emerged: organizational motivation; catalysts; organizational capacity to acquire and organizational capacity to transform research findings; moderating organizational factors. Also examined were the dissemination strategies used by ABSP and its abilities to enhance its capacity through networking, to advocate for more relevant research and to develop its potential role as knowledge broker, as well as limitations due to scarce resources. We conclude that a better understanding of the organizational capacity to use research of health professional associations in LMICs is needed to assess, improve and reinforce such capacity. Increased knowledge translation potential may leverage research resources and promote knowledge-sharing.

  10. Unpacking capacity to utilize research: A tale of the Burkina Faso public health association.

    PubMed

    Hamel, Nadia; Schrecker, Ted

    2011-01-01

    One of the most important challenges in addressing global health is for institutions to monitor and use research in policy-making. In low- and middle-income countries (LMICs), civil society organizations such as health professional associations can be key contributors to effective national health systems. However, there is little empirical data on their capacity to use research. This case study was used to gain insight into the factors that affect the knowledge translation performance of health professional associations in LMICs by describing the organizational elements and processes constituting capacity to use research, and examining the potential determinants of this capacity. Case study methodology was chosen for its flexibility to capture the multiple and often tacit processes within organizational routines. The Burkina Faso Public Health Association (ABSP) was studied, using in-depth, semi-structured interviews and key documents review. Five key dimensions that affect the association's capacity to use research to influence health policy emerged: organizational motivation; catalysts; organizational capacity to acquire and organizational capacity to transform research findings; moderating organizational factors. Also examined were the dissemination strategies used by ABSP and its abilities to enhance its capacity through networking, to advocate for more relevant research and to develop its potential role as knowledge broker, as well as limitations due to scarce resources. We conclude that a better understanding of the organizational capacity to use research of health professional associations in LMICs is needed to assess, improve and reinforce such capacity. Increased knowledge translation potential may leverage research resources and promote knowledge-sharing. PMID:21074923

  11. Misconduct in research: a descriptive survey of attitudes, perceptions and associated factors in a developing country

    PubMed Central

    2014-01-01

    Background Misconduct in research tarnishes the reputation, credibility and integrity of research institutions. Studies on research or scientific misconduct are still novel in developing countries. In this study, we report on the attitudes, perceptions and factors related to the work environment thought to be associated with research misconduct in a group of researchers in Nigeria - a developing country. Method A survey of researchers attending a scientific conference was done using an adapted Scientific Misconduct Questionnaire-Revised (SMQ-R). Initial descriptive analysis of individual items using frequencies and proportions for all quantitative data was performed. Thereafter, Likert scale responses were transformed into dichotomous responses. Fisher exact test was performed for associations as appropriate. A two-tailed p-value of less than 0.05 was accepted as significant. Result Half of the respondents (50.4%) were aware of a colleague who had committed misconduct, defined as “non-adherence to rules, regulations, guidelines, and commonly accepted professional codes or norms”. Over 88% of the researchers were concerned about the perceived amount of misconduct prevalent in their institution and 96.2% believed that one or more forms of scientific misconduct had occurred in their workplace. More than half (52.7%) rated the severity of penalties for scientific misconduct in their work environment as low. Furthermore¸ the majority (56.1%) were of the view that the chance of getting caught for scientific misconduct in their work environment was low. Conclusion Researchers in Nigeria perceive that scientific misconduct is commonplace in their institutions, but are however worried about the negative effects of scientific misconduct on the credibility of scientific research. We recommend that researchers be empowered with the knowledge and virtues necessary for self-regulation that advance research integrity. Research institutions should however also step into their

  12. SU-E-T-325: The New Evaluation Method of the VMAT Plan Delivery Using Varian DynaLog Files and Modulation Complexity Score (MCS)

    SciTech Connect

    Tateoka, K; Fujimomo, K; Hareyama, M; Saitou, Y; Nakazawa, T; Abe, T; Nakata, A; Yano, M

    2014-06-01

    Purpose: The aim of the study is to evaluate the use of Varian DynaLog files to verify VMAT plans delivery and modulation complexity score (MCS) of VMAT. Methods: Delivery accuracy of machine performance was quantified by multileaf collimator (MLC) position errors, gantry angle errors and fluence delivery accuracy for volumetric modulated arc therapy (VMAT). The relationship between machine performance and plan complexity were also investigated using the modulation complexity score (MCS). Plan and Actual MLC positions, gantry angles and delivered fraction of monitor units were extracted from Varian DynaLog files. These factors were taken from the record and verify system of MLC control file. Planned and delivered beam data were compared to determine leaf position errors and gantry angle errors. Analysis was also performed on planned and actual fluence maps reconstructed from those of the DynaLog files. This analysis was performed for all treatment fractions of 5 prostate VMAT plans. The analysis of DynaLog files have been carried out by in-house programming in Visual C++. Results: The root mean square of leaf position and gantry angle errors were about 0.12 and 0.15, respectively. The Gamma of planned and actual fluence maps at 3%/3 mm criterion was about 99.21. The gamma of the leaf position errors were not directly related to plan complexity as determined by the MCS. Therefore, the gamma of the gantry angle errors were directly related to plan complexity as determined by the MCS. Conclusion: This study shows Varian dynalog files for VMAT plan can be diagnosed delivery errors not possible with phantom based quality assurance. Furthermore, the MCS of VMAT plan can evaluate delivery accuracy for patients receiving of VMAT. Machine performance was found to be directly related to plan complexity but this is not the dominant determinant of delivery accuracy.

  13. Gray's Reinforcement Sensitivity Theory as a framework for research on personality-psychopathology associations.

    PubMed

    Bijttebier, Patricia; Beck, Ilse; Claes, Laurence; Vandereycken, Walter

    2009-07-01

    Gray's Reinforcement Sensitivity Theory (RST) presupposes individual differences in the sensitivity of basic brain systems that respond to punishing and reinforcing stimuli. These differences are thought to underlie the personality dimensions of anxiety and impulsivity, and to have relevance for psychopathology. The present article aims at reviewing RST-based research on personality-psychopathology associations. First, RST and its revisions are described and the link between RST systems and personality dimensions is discussed. Second, studies investigating associations between RST systems and specific types of psychopathology are summarized. Although the available research yields a rather consistent picture with respect to constellations of BIS/BAS sensitivity that are associated with specific types of psychopathology, it also provides a clear indication that much work remains to be done. The discussion section highlights several topics that deserve future research attention.

  14. The site of the Varian Temple of Elagabal in Rome: topographical and astronomical approach to the question

    NASA Astrophysics Data System (ADS)

    de Arrizabalaga y Prado, L.; de La Fuente Marcos, R.

    2005-03-01

    Ancient historians refer to a temple in Rome, dedicated to the Syrian sun god Elagabal, by his high priest, the Roman emperor called Varius (204-222AD, commonly called Elagabalus or Heliogabalus). On the basis of their texts, it has been thought that Varius either built a new temple, or rededicated an existing one, expropriated from some other deity, in order to house his god's principal cult object: a large black meteorite, or baetyl, which Varius brought from its temple at Emesa, in Syria, to Rome. In this paper we analyze the hypothesis that the site of the Varian Temple of Elagabal may have been that now known as the Vigna Barberini. A stratigraphic analysis shows that the Vigna Barberini is an artificial platform, built on the rubble of earlier hillside structures, dating from prehistoric times to the Julio-Claudian period. The platform, with more or less its present shape, is of Flavian date, and at that time contained a portico surrounding a central garden. On top of these, a Severan level corresponds to the base of the foundations of a temple that are very solid and go very deep. The azimuth of the temple wall oriented south-east is about 113°. Using a computer program, we have thoroughly scan ned the night sky in AD 1-250, looking for celestial objects that may have been worshipped in the temple. After taking into account the effects of precession, the main candidate for a celestial body worshipped from this site appears to be the star Sirius. In several Mediterranean cultures, the heliacal ortus, or earliest pre-dawn sighting of Sirius (when Sirius again rises into visibility after being hidden by the Sun's light for about 70 days) was thought to have astrological significance. We have compiled the relevant astronomical data for the heliacal ortus of Sirius in the time span 0-250 AD. During that period of time, it falls between 18th and 20th July. The azimuth angle of Sirius, when rising on the heliacal ortus day ci rca 150 AD, is about 111°. Being

  15. Production of 5' Nucleotide by Using Halophilic Nuclease H Preferentially Adsorbed on Flocculated Cells of the Halophile Micrococcus varians subsp. halophilus.

    PubMed

    Onishi, H; Kamekura, M; Yokoi, H; Kobayashi, T

    1988-11-01

    A bioreactor with a column of flocculated cells of the moderate halophile Micrococcus varians subsp. halophilus which adsorbed the halophilic nuclease H was designed to be used in the production of 5' nucleotides from RNA. A remarkable characteristic of the flocculated cells was that they preferentially adsorbed much exogenous nuclease, excluding adsorbed 5' nucleotidase. Furthermore, desalting treatment of the flocculated cells in the presence of 2% MgSO(4) . 7H(2)O gave rise to selective inactivation of 5' nucleotidase without the loss of nuclease H activity, and 5'-guanylic acid was produced with the bioreactor.

  16. Production of 5′ Nucleotide by Using Halophilic Nuclease H Preferentially Adsorbed on Flocculated Cells of the Halophile Micrococcus varians subsp. halophilus

    PubMed Central

    Onishi, Hiroshi; Kamekura, Masahiro; Yokoi, Haruhiko; Kobayashi, Takekazu

    1988-01-01

    A bioreactor with a column of flocculated cells of the moderate halophile Micrococcus varians subsp. halophilus which adsorbed the halophilic nuclease H was designed to be used in the production of 5′ nucleotides from RNA. A remarkable characteristic of the flocculated cells was that they preferentially adsorbed much exogenous nuclease, excluding adsorbed 5′ nucleotidase. Furthermore, desalting treatment of the flocculated cells in the presence of 2% MgSO4 · 7H2O gave rise to selective inactivation of 5′ nucleotidase without the loss of nuclease H activity, and 5′-guanylic acid was produced with the bioreactor. PMID:16347767

  17. Factors associated with willingness to participate in biospecimen research among Chinese Americans.

    PubMed

    Gao, Wanzhen; Ma, Grace X; Tan, Yin; Fang, Carolyn; Weaver, JoEllen; Jin, Ming; Lai, Philip

    2014-04-01

    A paucity of information exists on the recruitment of Asian Americans for biospecimen research. Although studies show that Chinese Americans are at high risk for hepatitis B virus (HBV) infection, little is known about their willingness to participate in HBV-related biospecimen research and how knowledge, attitudes, and cultural factors impact their willingness to participate. The study was guided by Community-Based Participatory Research principles. Data were derived from an assessment study on HBV-related biospecimen research participation among Chinese Americans in the Philadelphia region. The assessment was conducted with 415 Chinese Americans recruited from eight Chinese community-based organizations. Cultural beliefs, knowledge, and attitudes toward biospecimen research were examined for associations with their willingness to participate in biospecimen banking research. Overall, 192 (46.3%) of 415 participants who completed the assessment indicated they were willing to participate if they were invited to donate blood to be frozen and stored for future HBV biospecimen studies. Cultural variables significant in bivariate analysis included collectivism, knowledge about biospecimen research, and Yin-Yang beliefs. Fatalism and individualism were not associated with participation willingness. In multivariate analysis, age, health care attitudes, and trust were significantly associated with willingness to participate in biospecimen banking research. Asian American communities have little knowledge of biospecimen banking and will benefit from educational campaigns that emphasize collective benefits and attitudes towards and trust in the health care system. Understanding cultural factors is important for improving Chinese Americans' knowledge, awareness, and intentions of participation in biospecimen research. Similar efforts need to be undertaken to develop culturally appropriate educational intervention programs to increase participation in biospecimen research

  18. Factors associated with willingness to participate in biospecimen research among Chinese Americans.

    PubMed

    Gao, Wanzhen; Ma, Grace X; Tan, Yin; Fang, Carolyn; Weaver, JoEllen; Jin, Ming; Lai, Philip

    2014-04-01

    A paucity of information exists on the recruitment of Asian Americans for biospecimen research. Although studies show that Chinese Americans are at high risk for hepatitis B virus (HBV) infection, little is known about their willingness to participate in HBV-related biospecimen research and how knowledge, attitudes, and cultural factors impact their willingness to participate. The study was guided by Community-Based Participatory Research principles. Data were derived from an assessment study on HBV-related biospecimen research participation among Chinese Americans in the Philadelphia region. The assessment was conducted with 415 Chinese Americans recruited from eight Chinese community-based organizations. Cultural beliefs, knowledge, and attitudes toward biospecimen research were examined for associations with their willingness to participate in biospecimen banking research. Overall, 192 (46.3%) of 415 participants who completed the assessment indicated they were willing to participate if they were invited to donate blood to be frozen and stored for future HBV biospecimen studies. Cultural variables significant in bivariate analysis included collectivism, knowledge about biospecimen research, and Yin-Yang beliefs. Fatalism and individualism were not associated with participation willingness. In multivariate analysis, age, health care attitudes, and trust were significantly associated with willingness to participate in biospecimen banking research. Asian American communities have little knowledge of biospecimen banking and will benefit from educational campaigns that emphasize collective benefits and attitudes towards and trust in the health care system. Understanding cultural factors is important for improving Chinese Americans' knowledge, awareness, and intentions of participation in biospecimen research. Similar efforts need to be undertaken to develop culturally appropriate educational intervention programs to increase participation in biospecimen research

  19. Proceedings of the American Association of Oral and Maxillofacial Surgeons 2015 Research Summit.

    PubMed

    Cillo, Joseph E; Basi, David; Peacock, Zachary; Aghaloo, Tara; Bouloux, Gary; Dodson, Thomas; Edwards, Sean P; Kademani, Deepak

    2016-03-01

    The Fifth Biennial Research Summit of the American Association of Oral and Maxillofacial Surgeons and its Committee on Research Planning and Technology Assessment was held in Rosemont, Illinois on May 6 and 7, 2015. The goal of the symposium is to provide a forum for the most recent clinical and scientific advances to be brought to the specialty. The proceedings of the events of that summit are presented in this report. PMID:26707430

  20. Overview of innovative PMI research on NSTX-U and associated PMI facilities at PPPL

    SciTech Connect

    M. Ono; Jaworski, M.; Kaita, R.; Skinner, C. N.; Allain, J. P.; Maingi, R.; Scotti, F.; Soukhanovskii, V. A.

    2013-05-01

    Developing a reactor compatible divertor and managing the associated plasma material interaction (PMI) has been identified as a high priority research area for magnetic confinement fusion. Accordingly on NSTX-U, the PMI research has received a strong emphasis. Moreover, with ˜15 MW of auxiliary heating power, NSTX-U will be able to test the PMI physics with the peak divertor plasma facing component (PFC) heat loads of up to 40-60 MW/m2.

  1. Overview of innovative PMI research on NSTX-U and associated PMI facilities at PPPL

    DOE PAGES

    M. Ono; Jaworski, M.; Kaita, R.; Skinner, C. N.; Allain, J. P.; Maingi, R.; Scotti, F.; Soukhanovskii, V. A.

    2013-05-01

    Developing a reactor compatible divertor and managing the associated plasma material interaction (PMI) has been identified as a high priority research area for magnetic confinement fusion. Accordingly on NSTX-U, the PMI research has received a strong emphasis. Moreover, with ˜15 MW of auxiliary heating power, NSTX-U will be able to test the PMI physics with the peak divertor plasma facing component (PFC) heat loads of up to 40-60 MW/m2.

  2. NASA Space Biology Research Associate Program for the 21st Century

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, Gerald

    2000-01-01

    The Space Biology Research Associate Program for the 21st Century provided a unique opportunity to train individuals to conduct biological research in hypo- and hyper-gravity, and to conduct ground-based research. This grant was developed to maximize the potential for Space Biology as an emerging discipline and to train a cadre of space biologists. The field of gravitational and space biology is rapidly growing at the future of the field is reflected in the quality and education of its personnel. Our chief objective was to train and develop these scientists rapidly and in a cost effective model.

  3. A Research on the Association of Pavement Surface Damages Using Data Mining

    NASA Astrophysics Data System (ADS)

    Hung, Ching-Tsung; Chang, Jia-Ray; Chen, Jian-Da; Chou, Chien-Cheng; Chen, Shih-Huang

    The association of pavement surface damages used to rely on the judgments of the experts. However, with the accumulation of data in the pavement surface maintenance database and the improvement of Data Mining, there are more and more methods available to explore the association of pavement surface damages. This research adopts Apriori algorithm to conduct association analysis on pavement surface damages. From the experience of experts, it has been believed that the association of road damages is complicated. However, through case studies, it has been found that pavement surface damages are caused among longitudinal cracking, alligator cracking and pen-holes, and they are unidirectional influence. In addition, with the help of association rules, it has been learned that, in pavement surface preventative maintenance, the top priority should be the repair of longitudinal cracking and alligator cracking, which can greatly reduce the occurrence of pen-holes and the risk of state compensations.

  4. Advances in the prevention of oral disease; the role of the International Association for Dental Research

    PubMed Central

    2015-01-01

    Abstract Background Since its foundation in 1920, prevention of oral disease has been a priority for the International Association for Dental Research (IADR) and the commitment of the organisation to the subject area is clearly expressed in its mission to improve oral health worldwide. The IADR has a current global membership of almost 11,000 people who share an interest in oral and craniofacial research. Contribution of IADR This paper provides an overview of the contribution of IADR to supporting research and associated activities in disease prevention, in disseminating knowledge and in advocating for better oral health for all citizens of the world. It looks back over time and summarises current supports. Two more recent initiatives in disease prevention are described in more detail, the Global Oral Health Inequalities Research Agenda (GOHIRA) and the proceedings at the 2013 World Conference on Preventive Dentistry (WCPD, 2013), a joint initiative between IADR and WHO. Through organisational structure, meetings, publications, scientific groups and networks and external relations, IADR has been at the forefront of advancing research for the prevention of oral diseases. Conclusions IADR is committed to ensuring research advances get disseminated and implemented and at the same time encourages and advocates for basic, clinical and translational research across disciplines so that we may uncover the major breakthrough in prevention of oral disease. PMID:26391001

  5. Competence for Children's Sake: Summary Report of a Research Project on the Child Development Associate Credential.

    ERIC Educational Resources Information Center

    Pettygrove, Willa Bowman

    This report summarizes a research project on the Child Development Associate (CDA) assessment and credentialing system. The issues covered in the report fall under two general categories: validity (the ability of the CDA assessment/credential system to identify competent child care staff) and career development potential (the benefits of the CDA…

  6. A Report on the Peace Education Commission Program, International Peace Research Association Conference 2010, Sydney, Australia

    ERIC Educational Resources Information Center

    Toh, Swee-Hin

    2010-01-01

    From July 6th to 10th, 2010, International Peace Research Association (IPRA) held its biennial conference at the University of Sydney in Australia. Hosted by the University's Centre for Peace & Conflict Studies and coordinated by Jake Lynch and a team of dedicated staff and volunteers, the conference featured seven plenary panels and many papers…

  7. Recruitment Strategies and Costs Associated with Community-Based Research in a Mexican-Origin Population

    ERIC Educational Resources Information Center

    Mendez-Luck, Carolyn A.; Trejo, Laura; Miranda, Jeanne; Jimenez, Elizabeth; Quiter, Elaine S.; Mangione, Carol M.

    2011-01-01

    Purpose: We describe the recruitment strategies and personnel and materials costs associated with two community-based research studies in a Mexican-origin population. We also highlight the role that academic-community partnerships played in the outreach and recruitment process for our studies. We reviewed study documents using case study…

  8. AERA 2010 Web Communications Survey Report: "American Educational Research Association" January 2011

    ERIC Educational Resources Information Center

    Educational Researcher, 2011

    2011-01-01

    This report is intended to provide information to facilitate revision of the American Educational Research Association (AERA) website. All AERA members were invited to participate in an electronic survey to respond to questions about their assessments of the current website and their use of technology to access it. This report presents findings…

  9. National Association for Research in Science Teaching 48th Annual Meeting, Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    Helgeson, Stanley L., Ed.

    This publication was produced by the ERIC Information Analysis Center for Science, Mathematics, and Environmental Education in cooperation with the National Association for Research in Science Teaching (NARST) to provide abstracts of most of the papers presented at the 48th annual conference in Los Angeles, California, March 17-19, 1975. The…

  10. National Association for Research in Science Teaching 49th Annual Meeting, Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    Helgeson, Stanley L., Ed.

    This publication provides abstracts of papers presented at the 49th annual meeting of the National Association for Research in Science Teaching (NARST) held in San Francisco, April 23-25, 1976. The entries represent a wide range of topics in the field of science education. The themes recurring most often are related to the fields of: (1)…

  11. National Association for Research in Science Teaching 47th Annual meeting, Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    Helgeson, Stanley L., Ed.

    This publication was produced by the ERIC Information Analysis Center for Science, Mathematics, and Environmental Education in cooperation with the National Association for Research in Science Teaching (NARST) to provide abstracts of most of the papers presented at the NARST annual conference in Chicago, Illinois, on April 15-18, 1974. The…

  12. National Association for Research in Science Teaching, 45th Annual Meeting, Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    ERIC Information Analysis Center for Science Education, Columbus, OH.

    Abstracts of papers presented to the 45th Annual Meeting of the National Association for Research in Science Teaching are arranged according to the topic for the session at which they were presented. Series of sessions were devoted to test and instrument development, evaluation, learning theory, verbal behavior, instructional methods and…

  13. National Association for Research in Science Teaching. 50th Annual Meeting, Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    Helgeson, Stanley L., Ed.

    This publication provides abstracts of papers presented at the 50th annual meeting of the National Association for Research in Science Teaching held in Cincinnati, Ohio March 22-24, 1977. The entries represent a wide range of topics in the field of science education. Topics include instruction, teacher education, learning, enrollments, concept…

  14. National Association for Research in Science Teaching 44th Annual Meeting, Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    ERIC Information Analysis Center for Science Education, Columbus, OH.

    Abstracts of papers presented to the 44th Annual Meeting of the National Association for Research in Science Teaching are arranged according to the topic of the session at which they were presented. Separate sessions were devoted to elementary, secondary, junior high school, and college and university science teaching, with papers on evaluation,…

  15. The Dominance of Associative Theorizing in Implicit Attitude Research: Propositional and Behavioral Alternatives

    ERIC Educational Resources Information Center

    Hughes, Sean; Barnes-Holmes, Dermot; De Houwer, Jan

    2011-01-01

    In the present article we re-examine one of the most deeply entrenched assumptions in modern attitude research, namely, that implicit social cognition is a product of associations between mental representations. More precisely, we argue that the analysis of implicit social cognition in psychology is curtailed by the widespread adoption of the…

  16. 75 FR 44266 - Submission for OMB Review; Comment Request; Application for the Pharmacology Research Associate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... the Pharmacology Research Associate Program SUMMARY: Under the provisions of Section 3507(a)(1)(D) of... National Institutes of Health (NIH) has submitted to the Office of Management and Budget (OMB) a request to... valid OMB control number. Proposed Collection: Title: Application for the Pharmacology...

  17. DOE-NREL Minority University Research Associates Program FY 2005 Accomplishments

    SciTech Connect

    Eddy, F. P.

    2005-11-01

    The DOE-NREL Minority University Research Associates (MURA) Program encourages minority students to pursue careers in science and technology. In 2003, eight minority-serving institutions were awarded 3-year subcontracts that began in the summer/fall of FY 2004. This paper lists accomplishments made in the project's first phase.

  18. Factors Associated with Research Anxiety of University Human Resource Education Faculty

    ERIC Educational Resources Information Center

    Higgins, Chadwick C.; Kotrlik, Joe W.

    2006-01-01

    Factors associated with research anxiety of university faculty members in human resource educations fields were examined. Most of the participating faculty members were male and half were full professors. The mean age was 52 and all but one held a doctorate. Relationships between selected demographic characteristics and The Higgins-Kotrlik…

  19. High School Accreditation in Maine: Perceptions of Costs and Benefits. Penquis Superintendents' Association Research Report

    ERIC Educational Resources Information Center

    Fairman, Janet; Peirce, Brenda; Harris, Walter

    2009-01-01

    This report presents the findings of an exploratory study conducted by the Center for Research and Evaluation during the summer and fall of 2009, which focuses on perceptions of the costs and benefits of the accreditation process for high schools in Maine. The study was commissioned by the Penquis Superintendents' Association, a professional…

  20. Expanding the Epistemological Terrain: Increasing Equity and Diversity within the American Educational Research Association

    ERIC Educational Resources Information Center

    Banks, James A.

    2016-01-01

    During the civil rights movement of the 1960s and 1970s, the quest for civil rights by African Americans and other groups of color reverberated throughout the United States and the world, including within educational professional and research organizations, such as the Association for Supervision and Curriculum Development, the National Council of…

  1. Association for Counselor Education and Supervision Guidelines for Research Mentorship: Development and Implementation

    ERIC Educational Resources Information Center

    Borders, L. DiAnne; Wester, Kelly L.; Granello, Darcy Haag; Chang, Catherine Y.; Hays, Danica G.; Pepperell, Jennifer; Spurgeon, Shawn L.

    2012-01-01

    The authors describe guidelines endorsed by the Association for Counselor Education and Supervision for research mentorship, including characteristics of mentors and mentees. Suggestions for implementing the guidelines at the individual, program, institution, and professional levels are focused on enhancing mentoring relationships as well as…

  2. History and Culture of Alara--The Action Learning and Action Research Association

    ERIC Educational Resources Information Center

    Zuber-Skerritt, Ortrun; Passfield, Ron

    2016-01-01

    As co-founders of the Action Learning and Action Research Association (ALARA), we tell the story of this international network organisation through our personal experience. Our history traces the evolution of ALARA from origins at the first World Congress in 1990 in Brisbane, Australia, through development over two and a half decades, to its…

  3. The benefits associated with volunteering among seniors: a critical review and recommendations for future research.

    PubMed

    Anderson, Nicole D; Damianakis, Thecla; Kröger, Edeltraut; Wagner, Laura M; Dawson, Deirdre R; Binns, Malcolm A; Bernstein, Syrelle; Caspi, Eilon; Cook, Suzanne L

    2014-11-01

    There is an urgent need to identify lifestyle activities that reduce functional decline and dementia associated with population aging. The goals of this article are to review critically the evidence on the benefits associated with formal volunteering among older adults, propose a theoretical model of how volunteering may reduce functional limitations and dementia risk, and offer recommendations for future research. Database searches identified 113 papers on volunteering benefits in older adults, of which 73 were included. Data from descriptive, cross-sectional, and prospective cohort studies, along with 1 randomized controlled trial, most consistently reveal that volunteering is associated with reduced symptoms of depression, better self-reported health, fewer functional limitations, and lower mortality. The extant evidence provides the basis for a model proposing that volunteering increases social, physical, and cognitive activity (to varying degrees depending on characteristics of the volunteer placement) which, through biological and psychological mechanisms, leads to improved functioning; we further propose that these volunteering-related functional improvements should be associated with reduced dementia risk. Recommendations for future research are that studies (a) include more objective measures of psychosocial, physical, and cognitive functioning; (b) integrate qualitative and quantitative methods in prospective study designs; (c) explore further individual differences in the benefits associated with volunteering; (d) include occupational analyses of volunteers' specific jobs in order to identify their social, physical, and cognitive complexity; (e) investigate the independent versus interactive health benefits associated with volunteering relative to engagement in other forms of activity; and (f) examine the relationship between volunteering and dementia risk.

  4. Policy recommendations for addressing privacy challenges associated with cell-based research and interventions

    PubMed Central

    2014-01-01

    Background The increased use of human biological material for cell-based research and clinical interventions poses risks to the privacy of patients and donors, including the possibility of re-identification of individuals from anonymized cell lines and associated genetic data. These risks will increase as technologies and databases used for re-identification become affordable and more sophisticated. Policies that require ongoing linkage of cell lines to donors’ clinical information for research and regulatory purposes, and existing practices that limit research participants’ ability to control what is done with their genetic data, amplify the privacy concerns. Discussion To date, the privacy issues associated with cell-based research and interventions have not received much attention in the academic and policymaking contexts. This paper, arising out of a multi-disciplinary workshop, aims to rectify this by outlining the issues, proposing novel governance strategies and policy recommendations, and identifying areas where further evidence is required to make sound policy decisions. The authors of this paper take the position that existing rules and norms can be reasonably extended to address privacy risks in this context without compromising emerging developments in the research environment, and that exceptions from such rules should be justified using a case-by-case approach. In developing new policies, the broader framework of regulations governing cell-based research and related areas must be taken into account, as well as the views of impacted groups, including scientists, research participants and the general public. Summary This paper outlines deliberations at a policy development workshop focusing on privacy challenges associated with cell-based research and interventions. The paper provides an overview of these challenges, followed by a discussion of key themes and recommendations that emerged from discussions at the workshop. The paper concludes that

  5. Factors influencing clinical students' perceptions of an embedded research project and associated publication output.

    PubMed

    Weller, Renate; May, Stephen A

    2013-01-01

    In this article, we describe student perceptions of the value of a short, compulsory research project embedded in a clinical degree program, the research output in terms of publications, and the factors influencing this. It was hypothesized that student attitudes toward the project, student perceptions of how much the project contributed to their generic skills, and the number of publications submitted or prepared for submission would be associated with perceived quality of supervision, perceived difficulty of the project, career plans, and attitude before commencement of the project. We explored this using a questionnaire comprising 30 questions that included demographics, Likert scales, and categorical responses. Student attitudes toward research were found to be associated with student attitude before the start of the project, perceived difficulty of the project, perceived quality of supervision, and perceived relevance to the profession. Students thought that the research project contributed most to the skills of "information gathering" and "critical evaluation" and the least to "teamwork," "problem solving," and "oral communication." Research output was significantly linked to perceived quality of supervision and the help students received with data analysis and data collection, though not with the project report itself. In conclusion, although the success of the research project was influenced by many factors, the perceived quality of supervision influenced all three outcome measures. Therefore it is clear that optimization of this aspect offers the most scope for enhancing the student learning experience.

  6. Implementation of phantom-less IMRT delivery verification using Varian DynaLog files and R/V output.

    PubMed

    Agnew, C E; King, R B; Hounsell, A R; McGarry, C K

    2012-11-01

    This study aims to evaluate the use of Varian radiotherapy dynamic treatment log (DynaLog) files to verify IMRT plan delivery as part of a routine quality assurance procedure. Delivery accuracy in terms of machine performance was quantified by multileaf collimator (MLC) position errors and fluence delivery accuracy for patients receiving intensity modulated radiation therapy (IMRT) treatment. The relationship between machine performance and plan complexity, quantified by the modulation complexity score (MCS) was also investigated. Actual MLC positions and delivered fraction of monitor units (MU), recorded every 50 ms during IMRT delivery, were extracted from the DynaLog files. The planned MLC positions and fractional MU were taken from the record and verify system MLC control file. Planned and delivered beam data were compared to determine leaf position errors with and without the overshoot effect. Analysis was also performed on planned and actual fluence maps reconstructed from the MLC control file and delivered treatment log files respectively. This analysis was performed for all treatment fractions for 5 prostate, 5 prostate and pelvic node (PPN) and 5 head and neck (H&N) IMRT plans, totalling 82 IMRT fields in ∼5500 DynaLog files. The root mean square (RMS) leaf position errors without the overshoot effect were 0.09, 0.26, 0.19 mm for the prostate, PPN and H&N plans respectively, which increased to 0.30, 0.39 and 0.30 mm when the overshoot effect was considered. Average errors were not affected by the overshoot effect and were 0.05, 0.13 and 0.17 mm for prostate, PPN and H&N plans respectively. The percentage of pixels passing fluence map gamma analysis at 3%/3 mm was 99.94 ± 0.25%, which reduced to 91.62 ± 11.39% at 1%/1 mm criterion. Leaf position errors, but not gamma passing rate, were directly related to plan complexity as determined by the MCS. Site specific confidence intervals for average leaf position errors were set at -0.03-0.12 mm for

  7. Motivation to Work: How to Sustain a Research Career in Higher Education: A Summary of the 2011 Ohio Music Education Association Research Forum

    ERIC Educational Resources Information Center

    Bond, Vanessa L.

    2011-01-01

    Dr. James R. Austin, Professor of Music Education and Associate Dean for Undergraduate Studies at the University of Colorado at Boulder, was the guest speaker for the 2011 Ohio Music Education Association (OMEA) Research Committee's Graduate Research Forum held in conjunction with the annual OMEA Professional Development Conference. During his…

  8. Overview of Innovative PMI Research on NSTX-U and Associated PMI Facilities at PPPL

    SciTech Connect

    M. Ono, M. Jaworski, R. Kaita, C. N. Skinner, J.P. Allain, R. Maingi, F. Scotti, V.A. Soukhanovskii, and the NSTX-U Team

    2012-09-19

    Developing a reactor compatible divertor and managing the associated plasma material interaction (PMI) has been identified as a high priority research area for magnetic confinement fusion. Accordingly on NSTXU, the PMI research has received a strong emphasis. With ~ 15 MW of auxiliary heating power, NSTX-U will be able to test the PMI physics with the peak divertor plasma facing component (PFC) heat loads of up to 40-60 MW/m2 . To support the PMI research, a comprehensive set of PMI diagnostic tools are being implemented. The snow-flake configuration can produce exceptionally high divertor flux expansion of up to ~ 50. Combined with the radiative divertor concept, the snow-flake configuration has reduced the divertor heat flux by an order of magnitude in NSTX. Another area of active PMI investigation is the effect of divertor lithium coating (both in solid and liquid phases). The overall NSTX lithium PFC coating results suggest exciting opportunities for future magnetic confinement research including significant electron energy confinement improvements, Hmode power threshold reduction, the control of Edge Localized Modes (ELMs), and high heat flux handling. To support the NSTX-U/PPPL PMI research, there are also a number of associated PMI facilities implemented at PPPL/Princeton University including the Liquid Lithium R&D facility, Lithium Tokamak Experiment, and Laboratories for Materials Characterization and Surface Chemistry.

  9. Historical Research: A Thematic Analysis of Convention and Conference Themes for Selected Professional Health Education Associations from 1975 to 2009

    ERIC Educational Resources Information Center

    Black, Jill M.; Ubbes, Valerie A.

    2009-01-01

    Many professional organizations and associations hold conventions and conferences on an annual basis. Health Education professional associations take part in this process. Using a historical research perspective, this article delineates conference themes for four prominent professional Health Education associations: the American Association for…

  10. The Association of Polar Early Career Scientists - A Model for Young Researcher Programs

    NASA Astrophysics Data System (ADS)

    Pope, A.; Baeseman, J. L.

    2010-12-01

    Established in 2006 by young researchers in the early stages of the International Polar Year (IPY), the Association of Polar Early Career Scientists (APECS) has evolved into the pre-eminent international organization for polar researchers at early stages of their careers. Now comprising around 2000 members from approximately 45 countries, APECS represents a body of undergraduate and graduate students, postdoctoral researchers, early faculty members, educators and others with interests in Polar Regions and the cryosphere with the key aim of raising the profile of polar research by providing a continuum of leadership that is both international and interdisciplinary in focus, and stimulating collaborative projects in research, education and outreach. APECS provides a strong voice for young researchers, enabling information sharing between early-career and more established professionals, promoting and organizing science, education and outreach events, and being actively involved with other organizations in the support of polar research activities. These activities are guided by three overarching goals: *Facilitate international and interdisciplinary networking to share ideas and experiences and to develop new research directions and collaborations; *Provide opportunities for professional career development; and *Promote education and outreach as integral components of polar research and to stimulate future generations of polar researchers. This presentation highlights the major achievements of APECS since its inception as well as future steps that APECS plans to take to ensure its sustainability. APECS can serve as a model for other groups looking to encourage the next generation of researchers. Since its founding, APECS has strived to develop strong partnerships with international organizations and scientific bodies. This network has not only facilitated early-career representation on an international level but has also furthered many education and outreach

  11. [Experince accumulated by RADON Industrial Research Association in treating radioactive waste].

    PubMed

    Dmitriev, S A; Lifanov, F A; Kobelev, A P; Savkin, A E

    2006-01-01

    To reduce volume of radioactive waste for long storage, specialists in "RADON" Industrial Research Association according to qualitative contents of the waste use methods of filtration and selective sorption of radionuclides, electrolysis, monoselective purification, burning, plasmic burning and pressing. Overall volume of the waste processed by various plants exceeds 50 thousand cubic meters. The mentioned technologies could be widely used in radiochemical works and other nuclear energy plants. PMID:16568841

  12. Estrogen-receptor independent effects of two ubiquitous environmental estrogens on Melosira varians Agardh, a common component of the aquatic primary production community.

    PubMed

    Julius, Matthew L; Stepanek, Joshua; Tedrow, O'Neill; Gamble, Carolyn; Schoenfuss, Heiko L

    2007-11-15

    Estrogenic compounds have been discovered in many surface water samples in many anthropogenically altered surface waters. Wastewater effluent has been identified as a major pathway of contamination and found to revert much of the metabolic products of these biologically active compounds back to their original form. This presentation explains methodology for determining exposure effects through a newly developed bioassay, examining the physiological response of a diatom to these compounds. Diatoms represent an important aspect of the primary production community. They are a desirable food source over other members of the primary production community through storage of photosynthetically produced sugars in the form of lipids rather than starch. Therefore, many members of higher trophic levels selectively feed on diatoms when present with other members of the primary production community. This study examines the effects of 17beta-estradiol and 4-nonylphenol on the physiological development of the diatom species Melosira varians. Clearly, unicellular protists such as diatoms are not susceptible to these contaminants in a manner directly analogous to that expressed in vertebrates. However, estradiol and nonylphenol are lipophilic making them particularly effective in entering the diatom cell membrane. Melosira varians was selected because it commonly occurs in most freshwater environments and has been the subject of other toxicological studies. An adequate literature base also exists for evaluating results of this experiment. The species grows rapidly and is easy to maintain in culture. Comparing cell density, chl-a, and lipid content in control and exposed cultures allowed interpretation of how the species responded to varying compound concentrations. Results of this study revealed differences in responses to each compound. 17beta-estradiol appears to have no detrimental effect on M. varians, while 4-nonylphenol results in cell mortality with sufficient dosage. Similar

  13. Evaluation of IsoCal geometric calibration system for Varian linacs equipped with on-board imager and electronic portal imaging device imaging systems.

    PubMed

    Gao, Song; Du, Weiliang; Balter, Peter; Munro, Peter; Jeung, Andrew

    2014-01-01

    The purpose of this study is to evaluate the accuracy and reproducibility of the IsoCal geometric calibration system for kilovoltage (kV) and megavoltage (MV) imagers on Varian C-series linear accelerators (linacs). IsoCal calibration starts by imaging a phantom and collimator plate using MV images with different collimator angles, as well as MV and kV images at different gantry angles. The software then identifies objects on the collimator plate and in the phantom to determine the location of the treatment isocenter and its relation to the MV and kV imager centers. It calculates offsets between the positions of the imaging panels and the treatment isocenter as a function of gantry angle and writes a correction file that can be applied to MV and kV systems to correct for those offsets in the position of the panels. We performed IsoCal calibration three times on each of five Varian C-series linacs, each time with an independent setup. We then compared the IsoCal calibrations with a simplified Winston-Lutz (WL)-based system and with a Varian cubic phantom (VC)-based system. The maximum IsoCal corrections ranged from 0.7 mm to 1.5 mm for MV and 0.9 mm to 1.8 mm for kV imagers across the five linacs. The variations in the three calibrations for each linac were less than 0.2 mm. Without IsoCal correction, the WL results showed discrepancies between the treatment isocenter and the imager center of 0.9 mm to 1.6 mm (for the MV imager) and 0.5 mm to 1.1 mm (for the kV imager); with IsoCal corrections applied, the differences were reduced to 0.2 mm to 0.6 mm (MV) and 0.3 mm to 0.6 mm (kV) across the five linacs. The VC system was not as precise as the WL system, but showed similar results, with discrepancies of less than 1.0 mm when the IsoCal corrections were applied. We conclude that IsoCal is an accurate and consistent method for calibration and periodic quality assurance of MV and kV imaging systems.

  14. The European Hematology Association Roadmap for European Hematology Research: a consensus document

    PubMed Central

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    2016-01-01

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. PMID:26819058

  15. The European Hematology Association Roadmap for European Hematology Research: a consensus document.

    PubMed

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    2016-02-01

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. PMID:26819058

  16. The European Hematology Association Roadmap for European Hematology Research: a consensus document.

    PubMed

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    2016-02-01

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.

  17. The Association of Polar Early Career Scientists - Developing a Continuum of Polar Research

    NASA Astrophysics Data System (ADS)

    Pope, A.; Baeseman, J. L.

    2011-12-01

    Established in 2006 by young researchers in the early stages of the International Polar Year (IPY), the Association of Polar Early Career Scientists (APECS) has evolved into the pre-eminent international organization for polar researchers at early stages of their careers. Now comprising around 2600 members from approximately 74 countries, APECS represents a body of students, postdoctoral researchers, early faculty members, educators and others with interests in Polar Regions and the cryosphere with the key aim of raising the profile of polar research by providing a continuum of leadership that is both international and interdisciplinary in focus, and stimulating collaborative projects in research, education and outreach. APECS provides a strong voice for young researchers, enabling information sharing between early-career and more established professionals, promoting and organizing science, education and outreach events, and being actively involved with other organizations in the support of polar research. These activities are guided by three overarching goals: *Facilitate international and interdisciplinary networking to share ideas and experiences and to develop new research directions and collaborations; *Provide opportunities for professional career development; and *Promote education and outreach as integral components of polar research and to stimulate future generations of polar researchers. This presentation highlights the major achievements of APECS since its inception as well as future steps that APECS plans to take to ensure its sustainability. Since its founding, APECS has strived to develop strong partnerships with international organizations and scientific bodies. This network has not only facilitated early-career representation on an international level but has also furthered many education and outreach opportunities for young polar researchers. APECS core programs that include career development workshops and panels (including several associated

  18. The prostate, lung, colorectal, and ovarian cancer screening trial and its associated research resource.

    PubMed

    Zhu, Claire S; Pinsky, Paul F; Kramer, Barnett S; Prorok, Philip C; Purdue, Mark P; Berg, Christine D; Gohagan, John K

    2013-11-20

    The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial is a large-scale research effort conducted by the National Cancer Institute. PLCO offers an example of coordinated research by both the extramural and intramural communities of the National Institutes of Health. The purpose of this article is to describe the PLCO research resource and how it is managed and to assess the productivity and the costs associated with this resource. Such an in-depth analysis of a single large-scale project can shed light on questions such as how large-scale projects should be managed, what metrics should be used to assess productivity, and how costs can be compared with productivity metrics. A comprehensive publication analysis identified 335 primary research publications resulting from research using PLCO data and biospecimens from 2000 to 2012. By the end of 2012, a total of 9679 citations (excluding self-citations) have resulted from this body of research publications, with an average of 29.7 citations per article, and an h index of 45, which is comparable with other large-scale studies, such as the Nurses' Health Study. In terms of impact on public health, PLCO trial results have been used by the US Preventive Services Task Force in making recommendations concerning prostate and ovarian cancer screening. The overall cost of PLCO was $454 million over 20 years, adjusted to 2011 dollars, with approximately $37 million for the collection, processing, and storage of biospecimens, including blood samples, buccal cells, and pathology tissues.

  19. Institutional Research: New Challenges to an Evolving Role. Proceedings of the North East Association for Institutional Research Annual Conference (13th, Philadelphia, Pennsylvania, October 26-28, 1986).

    ERIC Educational Resources Information Center

    Baylis, Bayard, Comp.

    New challenges facing the institutional research profession are covered in these 1986 conference proceedings of the North East Association for Institutional Research. Paper titles and authors include: "Institutional Research at Mercer County Community College: The Changing Role in the Eighties" (F. L. Edwards); "Course Placement and Academic…

  20. Publishing Your Music Education Research: A Seminar for Future Authors--A Summary of the 2009 Ohio Music Education Association Research Forum Presented By Dr. Wendy Sims

    ERIC Educational Resources Information Center

    Schatt, Matthew D.

    2009-01-01

    The Ohio Music Education Association (OMEA) Research Committee annually hosts a Graduate Research Forum in conjunction with the OMEA's Professional Development Conference. In 2009, the guest speaker was Dr. Wendy Sims, Director of Music Education at the University of Missouri--Columbia and Editor of the Journal of Research in Music Education. An…

  1. Developing a clinical research associate training program at Dillard University: the impact of collaboration.

    PubMed

    Hurst, Charlotte; Dennis, Betty P

    2013-01-01

    In 2010 Dillard University and Louisiana State University Health Sciences Center in New Orleans collaborated to secure a five year-grant from the National Institute of Minority Health and Health Disparities of the National Institutes of Health to establish a Minority Health and Health Disparities Research Center (MHHDRC) located on the campus of Dillard University. The MHHDRC is the first Federally funded Center of Excellence in the state of Louisiana. Three cores of the Center operate to achieve its mission. One core includes a clinical research associate (CRA) training program. The major goal of the program is to increase the number of minority CRAs in the state of Louisiana, especially in New Orleans and, ultimately promote greater participation and retention of minorities in clinical trials research. This article discusses the initiation of the CRA training program, its planning, community outreach, implementation, integration of multiple resources and role of collaboration in the development of the MHHDRC including accomplishments, challenges and future plans.

  2. The Association of Religion Data Archives (ARDA): Online Research Data, Tools, and References

    PubMed Central

    Finke, Roger; Adamczyk, Amy

    2014-01-01

    The Association of Religion Data Archives (ARDA) currently archives over 400 local, national, and international data files, and offers a wide range of research tools to build surveys, preview data on-line, develop customized maps and reports of U.S. church membership, and examine religion differences across nations and regions of the world. The ARDA also supports reference and teaching tools that draw on the rich data archive. This research note offers a brief introduction to the quantitative data available for exploration or download, and a few of the website features most useful for research and teaching. Supported by the Lilly Endowment, the John Templeton Foundation, the Pennsylvania State University, and the Baylor Institute for Studies of Religion, all data downloads and online services are free of charge. PMID:25484914

  3. Common Alzheimer's Disease Research Ontology: National Institute on Aging and Alzheimer's Association collaborative project.

    PubMed

    Refolo, Lorenzo M; Snyder, Heather; Liggins, Charlene; Ryan, Laurie; Silverberg, Nina; Petanceska, Suzana; Carrillo, Maria C

    2012-07-01

    Alzheimer's disease is recognized as a public health crisis worldwide. As public and private funding agencies around the world enhance and expand their support of Alzheimer's disease research, there is an urgent need to coordinate funding strategies and leverage resources to maximize the impact on public health and avoid duplication of effort and inefficiency. Such coordination requires a comprehensive assessment of the current landscape of Alzheimer's disease research in the United States and internationally. To this end, the National Institute on Aging at the National Institutes of Health and the Alzheimer's Association developed the Common Alzheimer's Disease Research Ontology (CADRO) as a dynamic portfolio analysis tool that can be used by funding agencies worldwide for strategic planning and coordination.

  4. The benefits associated with volunteering among seniors: a critical review and recommendations for future research.

    PubMed

    Anderson, Nicole D; Damianakis, Thecla; Kröger, Edeltraut; Wagner, Laura M; Dawson, Deirdre R; Binns, Malcolm A; Bernstein, Syrelle; Caspi, Eilon; Cook, Suzanne L

    2014-11-01

    There is an urgent need to identify lifestyle activities that reduce functional decline and dementia associated with population aging. The goals of this article are to review critically the evidence on the benefits associated with formal volunteering among older adults, propose a theoretical model of how volunteering may reduce functional limitations and dementia risk, and offer recommendations for future research. Database searches identified 113 papers on volunteering benefits in older adults, of which 73 were included. Data from descriptive, cross-sectional, and prospective cohort studies, along with 1 randomized controlled trial, most consistently reveal that volunteering is associated with reduced symptoms of depression, better self-reported health, fewer functional limitations, and lower mortality. The extant evidence provides the basis for a model proposing that volunteering increases social, physical, and cognitive activity (to varying degrees depending on characteristics of the volunteer placement) which, through biological and psychological mechanisms, leads to improved functioning; we further propose that these volunteering-related functional improvements should be associated with reduced dementia risk. Recommendations for future research are that studies (a) include more objective measures of psychosocial, physical, and cognitive functioning; (b) integrate qualitative and quantitative methods in prospective study designs; (c) explore further individual differences in the benefits associated with volunteering; (d) include occupational analyses of volunteers' specific jobs in order to identify their social, physical, and cognitive complexity; (e) investigate the independent versus interactive health benefits associated with volunteering relative to engagement in other forms of activity; and (f) examine the relationship between volunteering and dementia risk. PMID:25150681

  5. Genetic Associations and Mechanisms in Oncology (GAME-ON): A Network of Consortia for Post-Genome Wide Association (Post-GWA) Research

    Cancer.gov

    The Genetic Associations and Mechanisms in Oncology's (GAME-ON) overall goal is to foster an intra-disciplinary and collaborative approach to the translation of promising research leads deriving from the initial wave of cancer GWAS.

  6. Mechanical characterization of the Varian Exact-arm and R-arm support systems for eight aS500 electronic portal imaging devices

    SciTech Connect

    Grattan, Mark W. D.; McGarry, Conor K.

    2010-04-15

    Purpose: The aim of this study is to compare the positioning accuracy at different gantry angles of two electronic portal imaging devices (EPIDs) support arm systems by using EPID difference images as a measure for displacement. This work presents a comparison of the mechanical performance of eight Varian aS500 (Varian Medical Systems, Palo Alto, CA) EPIDs, mounted using either the Varian Exact-arm or R-arm. Methods: The mechanical performance of the two arm systems was compared by investigating the variation in sensitivity with gantry angle, both before and after the EPID position was adjusted after gantry rotation. Positional errors were investigated by subtracting images from a reference image taken at gantry 0 deg., and the amplitude of the peaks and troughs at the field edges for longitudinal (radial) and lateral (transverse) profiles across the resulting image was related to the distance of displacement. Calibration curves based on a pixel-by-pixel shift were generated for each EPID and the Varian hand pendant accuracy was compared to the calibration data. Results: The response of the EPIDs was found to change with gantry rotation, with the largest difference at 180 deg. The Exact-arm was found to correct well for any displacement, while the R-arm tended to overcorrect following repositioning using the hand pendant. The calibration curves were consistent within each set of matched linacs, and the hand pendant accuracy was similar for both arm systems, although generally in different directions. With respect to gantry rotation effects, the mechanical performance of the Exact-arm systems was found to be much better than that of the R-arm systems. At gantry positions 90 deg., 270 deg., and 180 deg. the average misalignment in the longitudinal direction was +4.2{+-}0.2, +1.8{+-}1.6, and +7.4{+-}0.5 mm for the R-arms, and +2.9{+-}0.2, +2.1{+-}0.8, and +4.9{+-}0.7 mm for the Exact-arms. In the lateral direction the average positional errors were +2.1{+-}0.4, -4

  7. Poster — Thur Eve — 36: Implementation of constant dose rate and gantry speed arc therapy(CDR-CAS-IMAT) for thoracic esophageal carcinoma on Varian 23EX

    SciTech Connect

    Zhang, Ruohui; Fan, Xiaomei; Bai, Wenwen; Han, Chun

    2014-08-15

    Objective: The purpose of this study is to propose an alternative planning approach for VMAT using constant dose rate and gantry speed arc therapy(CDR-CAS-IMAT) implementation on conventional Linac Varian 23EX and used IMRT as a benchmark to evaluate the performance. Methods and materials: Eighteen patients with thoracic esophageal carcinoma who were previously treated with IMRT on Varian 23EX were retrospectively planned for CDR-CAS-IMAT plans. Dose prescription was set to 60 Gy to PTVs in 30 fractions. The planning objectives for PTVs and OAR were corresponding with the IMRT plans. Dose to the PTVs and OAR were compared to IMRT with respect to plan quality, MU, treatment time and delivery accuracy. Results: CDR-CAS-IMAT plans led to equivalent or superior plan quality as compared to IMRT, PTV's CI relative increased 16.2%, while small deviations were observed on minimum dose for PTV. Volumes in the cord receiving 40Gy were increased from 3.6% with IMRT to 7.0%. Treatment times were reduced significantly with CDR-CAS-IMAT(mean 85.7s vs. 232.1s, p < .05), however, MU increased by a factor of 1.3 and lung V10/5/3.5/aver were relative increase 6.7%,12%,17.9%,4.2%, respectively. And increased the E-P low dose area volume decreased the hight dose area. There were no significant difference in Delta4 measurements results between both planning techniques. Conclusion: CDR-CAS-IMAT plans can be implemented smoothly and quickly into a busy cancer center, which improved PTV CI and reduces treatment time but increased the MU and low dose irradiated area. An evaluation of weight loss must be performed during treatment for CDR-CAS-IMAT patients.

  8. Growth of a species, an association, a science: 80 years of growth and development research.

    PubMed

    Sherwood, Richard J; Duren, Dana L

    2013-01-01

    Physical anthropological research was codified in the United States with the creation of the American Association of Physical Anthropology (AAPA) in 1929. That same year, a study began in yellow springs, Ohio, with a goal of identifying "what makes people different." The approach used to answer that question was to study the growth and development of Homo sapiens. The resulting study, the Fels Longitudinal Study, is currently the longest continuous study of human growth and development in the world. Although the AAPA and the Fels Longitudinal Study have existed as separate entities for more than 80 years now, it is not surprising, given the relationship between anatomical and developmental research, there has been considerable overlap between the two. As the field of physical anthropology has blossomed to include subdisciplines such as forensics, genetics, primatology, as well as sophisticated statistical methodologies, the importance of growth and development research has escalated. Although current Fels Longitudinal Study research is largely directed at biomedical questions, virtually all findings are relevant to physical anthropology, providing insights into basic biological processes and life history parameters. Some key milestones from the early years of the AAPA and the Fels Longitudinal Study are highlighted here that address growth and development research in physical anthropology. These are still held as fundamental concepts that underscore the importance of this line of inquiry, not only across the subdisciplines of physical anthropology, but also among anthropological, biological, and biomedical inquiries.

  9. Navigating the Thin Line between Education and Incarceration: An Action Research Case Study on Gang-Associated Latino Youth

    ERIC Educational Resources Information Center

    Rios, Victor M.

    2010-01-01

    This article examines data collected from an ethnographic research project conducted with 56 gang-associated Latino youths ages 15 to 21 from 2007 to 2009. The objectives of the study were to examine how poor Latino gang-associated youths perceived schooling and policing and to find out if the research process could promote educational aspirations…

  10. Federated Search and the Library Web Site: A Study of Association of Research Libraries Member Web Sites

    ERIC Educational Resources Information Center

    Williams, Sarah C.

    2010-01-01

    The purpose of this study was to investigate how federated search engines are incorporated into the Web sites of libraries in the Association of Research Libraries. In 2009, information was gathered for each library in the Association of Research Libraries with a federated search engine. This included the name of the federated search service and…

  11. Images of Illness: How Causal Claims and Racial Associations Influence Public Preferences toward Diabetes Research Spending

    PubMed Central

    Gollust, Sarah E.; Lantz, Paula M.; Ubel, Peter A.

    2013-01-01

    Despite the salience of health disparities in media and policy discourse, little previous research has investigated if imagery associating an illness with a certain racial group influences public perceptions. This study evaluated the influence of the media’s presentation of the causes of type 2 diabetes and its implicit racial associations on attitudes toward people with diabetes and preferences toward research spending. Survey participants who viewed an article on genetic causation or social determinants of diabetes were more likely to support increased government spending on research than those viewing an article with no causal language, while participants viewing an article on behavioral choices were more likely to attribute negative stereotypes to people with diabetes. Participants who viewed a photo of a black woman accompanying the article were less likely to endorse negative stereotypes than those viewing a photo of a white woman, but those who viewed a photo of a glucose-testing device expressed the lowest negative stereotypes. The effect of social determinants language was significantly different for blacks and whites, lowering stereotypes only among blacks. Emphasizing the behavioral causes of diabetes, as is common in media coverage, may perpetuate negative stereotypes. While drawing attention to the social determinants that shape these behaviors could mitigate stereotypes, this strategy is unlikely to influence the public uniformly. PMID:21451158

  12. Association of Clinical Researchers and Educators a statement on relationships between physicians and industry.

    PubMed

    Weber, Michael A; Black, Henry R; Fonseca, Rafael; Garber, Jeffrey; Gonzalez-Campoy, J Michael; Kimmelstiel, Carey; Markowitz, Avi B; Nakayama, Don; Stell, Lance K; Stossel, Thomas P

    2012-01-01

    Collaborations between physicians, particularly those in academic medicine, and industries that develop pharmaceutical products, medical devices, and diagnostic tests have led to substantial advances in patient care. At the same time, there is a strong awareness that these relationships, however beneficial they may be, should conform to established principles of ethical professional practice. Through a writing committee drawn from diverse disciplines across several institutions, the Association of Clinical Researchers and Educators (ACRE) has written a code of conduct to provide guidance to physicians in observing these principles. Our recommendations are not intended to be prescriptive or inflexible, but rather to be of assistance to physicians in making their own personal decisions on whether, or how, to be involved in research, education, or other collaborations with industry.

  13. Research Opportunities for Cancer Associated with Indoor Air Pollution from Solid-Fuel Combustion

    PubMed Central

    Ghazarian, Armen A.; DeMarini, David M.; Sapkota, Amir; Jack, Darby; Lan, Qing; Winn, Deborah M.; Birnbaum, Linda S.

    2012-01-01

    Background: Indoor air pollution (IAP) derived largely from the use of solid fuels for cooking and heating affects about 3 billion people worldwide, resulting in substantial adverse health outcomes, including cancer. Women and children from developing countries are the most exposed populations. A workshop was held in Arlington, Virginia, 9–11 May 2011, to better understand women’s and children’s potential health effects from IAP in developing countries. Workshop participants included international scientists, manufacturers, policy and regulatory officials, community leaders, and advocates who held extensive discussions to help identify future research needs. Objectives: Our objective was to identify research opportunities regarding IAP and cancer, including research questions that could be incorporated into studies of interventions to reduce IAP exposure. In this commentary, we describe the state of the science in understanding IAP and its associations with cancer and suggest research opportunities for improving our understanding of the issues. Discussion: Opportunities for research on IAP and cancer include studies of the effect of IAP on cancers other than lung cancer; studies of genetic factors that modify susceptibility; studies to determine whether the effects of IAP are mediated via germline, somatic, and/or epigenetic changes; and studies of the effects of IAP exposure via dermal and/or oral routes. Conclusions: IAP from indoor coal use increases the risk of lung cancer. Installing chimneys can reduce risk, and some genotypes, including GSTM1-null, can increase risk. Additional research is needed regarding the effects of IAP on other cancers and the effects of different types of solid fuels, oral and dermal routes of IAP exposure, genetic and epigenetic mechanisms, and genetic susceptibility. PMID:22846419

  14. Factors associated with past research participation among low-income persons living with HIV.

    PubMed

    Slomka, Jacquelyn; Kypriotakis, Georgios; Atkinson, John; Diamond, Pamela M; Williams, Mark L; Vidrine, Damon J; Andrade, Roberto; Arduino, Roberto

    2012-08-01

    We described influences on past research participation among low-income persons living with HIV (PLWH) and examined whether such influences differed by study type. We analyzed a convenience sample of individuals from a large, urban clinic specializing in treating low-income PLWH. Using a computer-assisted survey, we elicited perceptions of research and participating in research, barriers, benefits, "trigger" influences, and self-efficacy in participating in research. Of 193 participants, we excluded 14 who did not identify any type of study participation, and 17 who identified "other" as study type, resulting in 162 cases for analysis. We compared results among four groups (i.e., 6 comparisons): past medical participants (n=36, 22%), past behavioral participants (n=49, 30%), individuals with no past research participation (n=52, 32%), and persons who had participated in both medical and behavioral studies (n=25, 15%). Data were analyzed using chi-square tests for categorical variables and ANOVA for continuous variables. We employed a multinomial probit (MNP) model to examine the association of multiple factors with the outcome. Confidence in ability to keep appointments, and worry about being a 'guinea pig' showed statistical differences in bivariate analyses. The MNP regression analysis showed differences between and across all 6 comparison groups. Fewer differences were seen across groupings of medical participants, behavioral participants, and those with no past research experience, than in comparisons with the medical-behavioral group. In the MNP regression model 'age' and level of certainty regarding 'keeping yourself from being a guinea pig' showed significant differences between past medical participants and past behavioral participants.

  15. The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and Its Associated Research Resource

    PubMed Central

    2013-01-01

    The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial is a large-scale research effort conducted by the National Cancer Institute. PLCO offers an example of coordinated research by both the extramural and intramural communities of the National Institutes of Health. The purpose of this article is to describe the PLCO research resource and how it is managed and to assess the productivity and the costs associated with this resource. Such an in-depth analysis of a single large-scale project can shed light on questions such as how large-scale projects should be managed, what metrics should be used to assess productivity, and how costs can be compared with productivity metrics. A comprehensive publication analysis identified 335 primary research publications resulting from research using PLCO data and biospecimens from 2000 to 2012. By the end of 2012, a total of 9679 citations (excluding self-citations) have resulted from this body of research publications, with an average of 29.7 citations per article, and an h index of 45, which is comparable with other large-scale studies, such as the Nurses’ Health Study. In terms of impact on public health, PLCO trial results have been used by the US Preventive Services Task Force in making recommendations concerning prostate and ovarian cancer screening. The overall cost of PLCO was $454 million over 20 years, adjusted to 2011 dollars, with approximately $37 million for the collection, processing, and storage of biospecimens, including blood samples, buccal cells, and pathology tissues. PMID:24115361

  16. Mid-South Educational Research Association Proceedings of the Annual Meeting (26th, Memphis, Tennessee, November 12-14, 1997).

    ERIC Educational Resources Information Center

    Petry, John R., Ed.; Post, Kathy, Ed.; Allen, Lorraine; Welch, Elizabeth

    The Mid-South Educational Research Association (MSERA) is a nonprofit organization with the purpose of encouraging quality educational research in the mid-south and promoting the application of results of quality research in the schools. This volume contains summaries of the papers, discussion sessions, display sessions, symposia, and training…

  17. Challenges of Implementing the NIH Extramural Associate Research Development Award (EARDA) at a Minority-Serving University

    ERIC Educational Resources Information Center

    Pickens, Jeffrey

    2010-01-01

    The impacts and challenges of implementing an NIH/NICHD Extramural Associate Research Development Award (EARDA) at a private Minority-Serving-Institution (MSI) are examined. This article outlines efforts to gain institutional buy-in and challenges encountered in creating a functioning Office of Sponsored Research and implementing research policies…

  18. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.

    PubMed

    2014-01-01

    Published research in English-language journals are increasingly required to carry a statement that the study has been approved and monitored by an Institutional Review Board in conformance with 45 CFR 46 standards if the study was conducted in the United States. Alternative language attesting conformity with the Helsinki Declaration is often included when the research was conducted in Europe or elsewhere. The Helsinki Declaration was created by the World Medical Association in 1964 (ten years before the Belmont Report) and has been amended several times. The Helsinki Declaration differs from its American version in several respects, the most significant of which is that it was developed by and for physicians. The term "patient" appears in many places where we would expect to see "subject." It is stated in several places that physicians must either conduct or have supervisory control of the research. The dual role of the physician-researcher is acknowledged, but it is made clear that the role of healer takes precedence over that of scientist. In the United States, the federal government developed and enforces regulations on researcher; in the rest of the world, the profession, or a significant part of it, took the initiative in defining and promoting good research practice, and governments in many countries have worked to harmonize their standards along these lines. The Helsinki Declaration is based less on key philosophical principles and more on prescriptive statements. Although there is significant overlap between the Belmont and the Helsinki guidelines, the latter extends much further into research design and publication. Elements in a research protocol, use of placebos, and obligation to enroll trials in public registries (to ensure that negative findings are not buried), and requirements to share findings with the research and professional communities are included in the Helsinki Declaration. As a practical matter, these are often part of the work of American

  19. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.

    PubMed

    2014-01-01

    Published research in English-language journals are increasingly required to carry a statement that the study has been approved and monitored by an Institutional Review Board in conformance with 45 CFR 46 standards if the study was conducted in the United States. Alternative language attesting conformity with the Helsinki Declaration is often included when the research was conducted in Europe or elsewhere. The Helsinki Declaration was created by the World Medical Association in 1964 (ten years before the Belmont Report) and has been amended several times. The Helsinki Declaration differs from its American version in several respects, the most significant of which is that it was developed by and for physicians. The term "patient" appears in many places where we would expect to see "subject." It is stated in several places that physicians must either conduct or have supervisory control of the research. The dual role of the physician-researcher is acknowledged, but it is made clear that the role of healer takes precedence over that of scientist. In the United States, the federal government developed and enforces regulations on researcher; in the rest of the world, the profession, or a significant part of it, took the initiative in defining and promoting good research practice, and governments in many countries have worked to harmonize their standards along these lines. The Helsinki Declaration is based less on key philosophical principles and more on prescriptive statements. Although there is significant overlap between the Belmont and the Helsinki guidelines, the latter extends much further into research design and publication. Elements in a research protocol, use of placebos, and obligation to enroll trials in public registries (to ensure that negative findings are not buried), and requirements to share findings with the research and professional communities are included in the Helsinki Declaration. As a practical matter, these are often part of the work of American

  20. Clinical-histological associations in gastroparesis: Results from the Gastroparesis Clinical Research Consortium

    PubMed Central

    2012-01-01

    Background Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. Aim Relate cellular changes to symptoms and gastric emptying in patients with gastroparesis. Methods Earlier, using full thickness gastric body biopsies from 20 DG, 20 IG and 20 matched controls, we found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both DG and IG. Here, demographic, symptoms (gastroparesis cardinal symptom index score), and gastric emptying were related to cellular alterations using Pearson’s correlation coefficients. Results ICC counts inversely correlated with 4 hours gastric retention in DG but not in IG (r=−0.6, p=0.008, DG, r=0.2, p=0.4, IG). There was also a significant correlation between loss of ICC and enteric nerves in DG but not in IG (r=0.5, p=0.03 for DG, r=0.3, p=0.16, IG). IG with a myenteric immune infiltrate scored higher on the average GCSI (3.6±0.7 vs 2.7±0.9, p=0.05) and nausea score (3.8±0.9 vs 2.6±1.0, p=0.02) as compared to those without an infiltrate. Conclusions In DG, loss of ICC is associated with delayed gastric emptying. ICC or enteric nerve loss did not correlate with symptom severity. Overall clinical severity and nausea in IG is associated with a myenteric immune infiltrate. Thus, full thickness gastric biopsies can help define specific cellular abnormalities in gastroparesis, some of which are associated with physiological and clinical characteristics of gastroparesis. PMID:22339929

  1. Arts and Learning Research, 1994. The Journal of the Arts and Learning Special Interest Group of the American Educational Research Association (New Orleans, Louisiana, April 1994).

    ERIC Educational Resources Information Center

    Blair, Lorrie, Ed.; Morbey, Mary Leigh, Ed.

    1994-01-01

    The research papers gathered in this volume were presented at the 1994 meeting of the American Educational Research Association as part of the Arts and Learning Special Interest Group program. Papers collected in the volume represent an eclectic view of arts education and include music education. Following an editorial, papers are: "Arts and…

  2. Research in Science Education, Volume 1990. Selected Refereed Papers from the Annual Conference of the Australasian Science Education Research Association (21st, Perth, Western Australia, July 1990).

    ERIC Educational Resources Information Center

    Gardner, Paul L., Ed.

    1990-01-01

    This book contains selected refereed papers from the 21st Annual Conference of the Australasian Science Education Research Association. The papers are as follows: "A Learning Model for Science Education: Developing Teaching Strategies" (Appleton); "Researching Balance between Cognition and Affect in Science Teaching" (Baird et al.); "Toward a…

  3. The Future of Institutional Research. Proceedings of the Annual Conference of the Southern Association for Institutional Research (Orlando, Florida, October 24-26, 1979).

    ERIC Educational Resources Information Center

    Salley, Charles D., Ed.; And Others

    Proceedings of the 1979 conference of the Southern Association for Institutional Research (SAIR) are presented. The conference theme was the future of institutional research. Contents include reports of preconference workshops, speeches, panel reports, abstracts of papers, and reports pertaining to the affairs of the SAIR. Documents and authors…

  4. Institutional Research and Academic Outcomes. Proceedings of the Association for Institutional Research Annual Forum. (8th, San Francisco, California, May 6-9, 1968.)

    ERIC Educational Resources Information Center

    Fincher, Cameron, Ed.

    The theme of the 8th Annual Forum on Institutional Research was "Institutional Research and Academic Outcomes" -- intended as a continuation of the 1966 Forum discussion dealing with academic inputs and the 1967 Forum on the instructional process. After an address by the Association's president in which he urged his academic colleagues to…

  5. Institutional Research: Leadership through Excellence. North East Association for Institutional Research Annual Conference Proceedings (28th, Cambridge, Massachusetts, November 17-20, 2001).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    The theme of the 2001 annual conference of the Northeast Association for Institutional Research was Institutional Research: Leadership through Excellence. These proceedings represent the intellectual content and insights shared during the conference. The papers are: (1) The Rocky Road to Graduation: An Academic Career Flow Model for Tracking…

  6. The 1984 Research Report to the Texas Association of Junior and Community College Instructional Administrators. Junior and Community College Research: Texas, 1983-84.

    ERIC Educational Resources Information Center

    Texas Association of Junior and Community Coll. Instructional Administrators.

    Reports and abstracts of research studies conducted by members of the Research Committee of the Texas Association of Junior and Community College Instructional Administrators are provided. Section I presents the following reports: "A Learner Analysis Experiment: Cognitive Style versus Learning Style in Undergraduate Nursing Education," by Charles…

  7. Hispanic Association of Colleges and Universities (HACU) Hispanic Higher Education Research Collective (H3ERC) Research Agenda: Impacting Education and Changing Lives through Understanding

    ERIC Educational Resources Information Center

    Hispanic Association of Colleges and Universities, 2011

    2011-01-01

    With support from the Lumina Foundation, the Hispanic Association of Colleges and Universities (HACU) has launched HACU's Hispanic Higher Education Research Collective (H3ERC). The first major task of this virtual gathering of researchers and practitioners in Hispanic higher education has been to assess the state of our knowledge of the key issues…

  8. Research Libraries: Measurement, Management, Marketing. Minutes of the Meeting of the Association of Research Libraries (108th, Minneapolis, Minnesota, May 1-2, 1986).

    ERIC Educational Resources Information Center

    Daval, Nicola, Ed.

    Program presentations on issues related to the use of statistics by research libraries and business meeting minutes are combined in this report from the Association of Research Libraries (ARL). The full text is provided for the three papers on the program theme that were presented at the meeting: (1) "Information to Manage--The Economics of…

  9. Workshop Report from the NIH Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD)

    PubMed Central

    Bochner, Bruce S.; Book, Wendy; Busse, William W.; Butterfield, Joseph; Furuta, Glenn T.; Gleich, Gerald J.; Klion, Amy D.; Lee, James J.; Leiferman, Kristin M.; Minnicozzi, Michael; Moqbel, Redwan; Rothenberg, Marc E.; Schwartz, Lawrence B.; Simon, Hans-Uwe; Wechsler, Michael E.; Weller, Peter F.

    2012-01-01

    Background Eosinophils are blood cells that are often found in high numbers in the tissues of allergic conditions and helminthic parasite infections. The pathophysiological roles that eosinophils may serve in other human ‘eosinophil-associated’ diseases remain obscure. Objective NIH Institutes and the Office of Disease Prevention assembled an international taskforce of clinical and basic scientists with the charge to propose and prioritize unmet research needs in eosinophil-associated diseases. Methods The taskforce used an organ system approach to dissect out the different and common themes of eosinophil cell involvement in these diseases. In early 2012, a draft document was circulated for review. The document was amended and the prioritizations were set at a NIH-organized workshop in June 2012. Results The taskforce identified significant research needs. These needs cross disease entities but some are disease-specific. There are substantial shortcomings to the various preclinical animal models, as well as significant gaps in our epidemiologic, pathophysiologic, diagnostic, prognostic and therapeutic knowledge. The taskforce recognized that recent efforts by patient advocacy groups have played instrumental roles in improving the identification and characterization of these disorders. However, communication amongst the eosinophil interested communities, e.g., governmental funding and regulatory agencies, and industry and clinician scientists need to be more comprehensive. Conclusions Significant efforts are required to address our knowledge gaps in order to improve the outcomes of eosinophil-associated diseases. NIH Institutes, other federal agencies, lay organizations and the pharmaceutical industry should consider the taskforce’s recommendations in their future research activities. PMID:22935587

  10. Challenges Associated With Using Large Data Sets for Quality Assessment and Research in Clinical Settings.

    PubMed

    Cohen, Bevin; Vawdrey, David K; Liu, Jianfang; Caplan, David; Furuya, E Yoko; Mis, Frederick W; Larson, Elaine

    2015-08-01

    The rapidly expanding use of electronic records in health-care settings is generating unprecedented quantities of data available for clinical, epidemiological, and cost-effectiveness research. Several challenges are associated with using these data for clinical research, including issues surrounding access and information security, poor data quality, inconsistency of data within and across institutions, and a paucity of staff with expertise to manage and manipulate large clinical data sets. In this article, we describe our experience with assembling a data-mart and conducting clinical research using electronic data from four facilities within a single hospital network in New York City. We culled data from several electronic sources, including the institution's admission-discharge-transfer system, cost accounting system, electronic health record, clinical data warehouse, and departmental records. The final data-mart contained information for more than 760,000 discharges occurring from 2006 through 2012. Using categories identified by the National Institutes of Health Big Data to Knowledge initiative as a framework, we outlined challenges encountered during the development and use of a domain-specific data-mart and recommend approaches to overcome these challenges.

  11. Challenges Associated With Using Large Data Sets for Quality Assessment and Research in Clinical Settings

    PubMed Central

    Cohen, Bevin; Vawdrey, David K.; Liu, Jianfang; Caplan, David; Furuya, E. Yoko; Mis, Frederick W.; Larson, Elaine

    2015-01-01

    The rapidly expanding use of electronic records in health-care settings is generating unprecedented quantities of data available for clinical, epidemiological, and cost-effectiveness research. Several challenges are associated with using these data for clinical research, including issues surrounding access and information security, poor data quality, inconsistency of data within and across institutions, and a paucity of staff with expertise to manage and manipulate large clinical data sets. In this article, we describe our experience with assembling a data-mart and conducting clinical research using electronic data from four facilities within a single hospital network in New York City. We culled data from several electronic sources, including the institution’s admission-discharge-transfer system, cost accounting system, electronic health record, clinical data warehouse, and departmental records. The final data-mart contained information for more than 760,000 discharges occurring from 2006 through 2012. Using categories identified by the National Institutes of Health Big Data to Knowledge initiative as a framework, we outlined challenges encountered during the development and use of a domain-specific data-mart and recommend approaches to overcome these challenges. PMID:26351216

  12. Challenges Associated With Using Large Data Sets for Quality Assessment and Research in Clinical Settings.

    PubMed

    Cohen, Bevin; Vawdrey, David K; Liu, Jianfang; Caplan, David; Furuya, E Yoko; Mis, Frederick W; Larson, Elaine

    2015-08-01

    The rapidly expanding use of electronic records in health-care settings is generating unprecedented quantities of data available for clinical, epidemiological, and cost-effectiveness research. Several challenges are associated with using these data for clinical research, including issues surrounding access and information security, poor data quality, inconsistency of data within and across institutions, and a paucity of staff with expertise to manage and manipulate large clinical data sets. In this article, we describe our experience with assembling a data-mart and conducting clinical research using electronic data from four facilities within a single hospital network in New York City. We culled data from several electronic sources, including the institution's admission-discharge-transfer system, cost accounting system, electronic health record, clinical data warehouse, and departmental records. The final data-mart contained information for more than 760,000 discharges occurring from 2006 through 2012. Using categories identified by the National Institutes of Health Big Data to Knowledge initiative as a framework, we outlined challenges encountered during the development and use of a domain-specific data-mart and recommend approaches to overcome these challenges. PMID:26351216

  13. Monte Carlo simulation of TrueBeam flattening-filter-free beams using Varian phase-space files: Comparison with experimental data

    SciTech Connect

    Belosi, Maria F.; Fogliata, Antonella E-mail: afc@iosi.ch; Cozzi, Luca; Clivio, Alessandro; Nicolini, Giorgia; Vanetti, Eugenio; Rodriguez, Miguel; Sempau, Josep; Krauss, Harald; Khamphan, Catherine; Fenoglietto, Pascal; Puxeu, Josep; Fedele, David; Mancosu, Pietro; Brualla, Lorenzo

    2014-05-15

    Purpose: Phase-space files for Monte Carlo simulation of the Varian TrueBeam beams have been made available by Varian. The aim of this study is to evaluate the accuracy of the distributed phase-space files for flattening filter free (FFF) beams, against experimental measurements from ten TrueBeam Linacs. Methods: The phase-space files have been used as input in PRIMO, a recently released Monte Carlo program based on thePENELOPE code. Simulations of 6 and 10 MV FFF were computed in a virtual water phantom for field sizes 3 × 3, 6 × 6, and 10 × 10 cm{sup 2} using 1 × 1 × 1 mm{sup 3} voxels and for 20 × 20 and 40 × 40 cm{sup 2} with 2 × 2 × 2 mm{sup 3} voxels. The particles contained in the initial phase-space files were transported downstream to a plane just above the phantom surface, where a subsequent phase-space file was tallied. Particles were transported downstream this second phase-space file to the water phantom. Experimental data consisted of depth doses and profiles at five different depths acquired at SSD = 100 cm (seven datasets) and SSD = 90 cm (three datasets). Simulations and experimental data were compared in terms of dose difference. Gamma analysis was also performed using 1%, 1 mm and 2%, 2 mm criteria of dose-difference and distance-to-agreement, respectively. Additionally, the parameters characterizing the dose profiles of unflattened beams were evaluated for both measurements and simulations. Results: Analysis of depth dose curves showed that dose differences increased with increasing field size and depth; this effect might be partly motivated due to an underestimation of the primary beam energy used to compute the phase-space files. Average dose differences reached 1% for the largest field size. Lateral profiles presented dose differences well within 1% for fields up to 20 × 20 cm{sup 2}, while the discrepancy increased toward 2% in the 40 × 40 cm{sup 2} cases. Gamma analysis resulted in an agreement of 100% when a 2%, 2 mm criterion

  14. The Undergraduate-Postgraduate-Faculty Triad: Unique Functions and Tensions Associated with Undergraduate Research Experiences at Research Universities

    ERIC Educational Resources Information Center

    Dolan, Erin L.; Johnson, Deborah

    2010-01-01

    We present an exploratory study of how undergraduates' involvement in research influences postgraduates (i.e., graduate and postdoctoral researchers) and faculty. We used a qualitative approach to examine the relationships among undergraduates, postgraduates, and the faculty head in a research group. In this group, undergraduates viewed…

  15. Who Shares? Who Doesn't? Factors Associated with Openly Archiving Raw Research Data

    PubMed Central

    Piwowar, Heather A.

    2011-01-01

    Many initiatives encourage investigators to share their raw datasets in hopes of increasing research efficiency and quality. Despite these investments of time and money, we do not have a firm grasp of who openly shares raw research data, who doesn't, and which initiatives are correlated with high rates of data sharing. In this analysis I use bibliometric methods to identify patterns in the frequency with which investigators openly archive their raw gene expression microarray datasets after study publication. Automated methods identified 11,603 articles published between 2000 and 2009 that describe the creation of gene expression microarray data. Associated datasets in best-practice repositories were found for 25% of these articles, increasing from less than 5% in 2001 to 30%–35% in 2007–2009. Accounting for sensitivity of the automated methods, approximately 45% of recent gene expression studies made their data publicly available. First-order factor analysis on 124 diverse bibliometric attributes of the data creation articles revealed 15 factors describing authorship, funding, institution, publication, and domain environments. In multivariate regression, authors were most likely to share data if they had prior experience sharing or reusing data, if their study was published in an open access journal or a journal with a relatively strong data sharing policy, or if the study was funded by a large number of NIH grants. Authors of studies on cancer and human subjects were least likely to make their datasets available. These results suggest research data sharing levels are still low and increasing only slowly, and data is least available in areas where it could make the biggest impact. Let's learn from those with high rates of sharing to embrace the full potential of our research output. PMID:21765886

  16. SU-E-T-128: Dosimetric Evaluation of MLC Modeling in Pinnacle V9.2 for Varian TrueBeam STx

    SciTech Connect

    Otageri, P; Grant, E; Maricle, S; Mathews, B

    2014-06-01

    Purpose: To evaluate the effects of MLC modeling after commissioning the Varian TrueBeam LINAC in Pinnacle version 9.2. Methods: Stepand-shoot IMRT QAs were investigated when we observed our measured absolute dose results using ion chamber (Capintec PR-05P) were uncharacteristically low; about 4–5% compared to doses calculated by Pinnacle{sup 3} (Phillips, Madison, WI). This problem was predominant for large and highly modulated head and neck (HN) treatments. Intuitively we knew this had to be related to shortcomings in the MLC modeling in Pinnacle. Using film QA we were able to iteratively adjust the MLC parameters. We confirmed results by re-testing five failed IMRT QA patients; and ion chamber measurements were verified in Quasar anthropomorphic phantom. Results: After commissioning the LINAC in Pinnacle version 9.2, the MLC transmission for 6X, 10X and 15X were 2.0%, 1.7% and 2.0%, respectively, and additional Interleaf leakage for all three energies was 0.5%. These parameters were obtained from profiles scanned with an Edge detector (Sun Nuclear, Melbourne, FL) during machine commissioning. A Verification testing with radiographic EDR2 film (Kodak, Rochester, NY) measurement was performed by creating a closed MLC leaf pattern and analyzing using RIT software (RIT, Colorado Springs, CO). This reduced MLC transmission for 6X, 10X and 15X to 0.7%, 0.9% and 0.9%, respectively; while increasing additional Interleaf leakage for all three energies to 1.0%. Conclusion: Radiographic film measurements were used to correct MLC transmission values for step and shoot IMRT fields used in Pinnacle version 9.2. After adjusting the MLC parameters to correlate with the film QA, there was still very good agreement between the Pinnacle model and commissioning data. Using the same QA methodology, we were also able to improve the beam models for the Varian C-series linacs, Novalis-Tx, and TrueBeam M-120 linacs.

  17. American Vocational Education Research Association (AVERA) Annual Research Meeting in Conjunction with the Annual Convention of the Association for Career and Technical Education. Proceedings (Orlando, Florida, December 11-13, 1999).

    ERIC Educational Resources Information Center

    Camp, William G., Ed.

    This document contains 14 research papers presented at the American Vocational Education Research Association (AVERA) annual meeting. The following papers are included: "Factors that Influence Students to Attend 4-Year Automotive Programs" (Gregory G. Belcher, Robert L. Frisbee); "The Training Needs of Vocational Teachers for Working with Special…

  18. The real-time learning mechanism of the Scientific Research Associates Advanced Robotic System (SRAARS)

    NASA Technical Reports Server (NTRS)

    Chen, Alexander Y.

    1990-01-01

    Scientific research associates advanced robotic system (SRAARS) is an intelligent robotic system which has autonomous learning capability in geometric reasoning. The system is equipped with one global intelligence center (GIC) and eight local intelligence centers (LICs). It controls mainly sixteen links with fourteen active joints, which constitute two articulated arms, an extensible lower body, a vision system with two CCD cameras and a mobile base. The on-board knowledge-based system supports the learning controller with model representations of both the robot and the working environment. By consecutive verifying and planning procedures, hypothesis-and-test routines and learning-by-analogy paradigm, the system would autonomously build up its own understanding of the relationship between itself (i.e., the robot) and the focused environment for the purposes of collision avoidance, motion analysis and object manipulation. The intelligence of SRAARS presents a valuable technical advantage to implement robotic systems for space exploration and space station operations.

  19. The General Electric-Association of University Radiologists Radiology Research Academic Fellowship (GERRAF). An industry-academic collaboration to improve clinical research in radiology.

    PubMed

    Hillman, B J; Fryback, D G; Holden, R W; McNeil, B J; Molitor, R M; Moss, A A; Peck, P V; Putman, C E; Thompson, W M

    1993-05-01

    The association of GE Medical Systems and the AUR represents a unique collaboration between academic radiology and industry that bears important potential for elevating the quality of clinical research in radiology and developing a cadre of high-quality radiologist researchers for the future. The establishment of the GERRAF is especially timely given the new imperatives of the rapidly changing health care environment, with its emphasis on expenditure reduction. The ultimate goals of GERRAF are to develop research leaders for radiology that will provide guidance for appropriate clinical practice, better train future researchers, and secure the role of radiologists in caring for patients.

  20. Trends in health sciences library and information science research: an analysis of research publications in the Bulletin of the Medical Library Association and Journal of the Medical Library Association from 1991 to 2007*

    PubMed Central

    Gore, Sally A.; Nordberg, Judith M.; Palmer, Lisa A.

    2009-01-01

    Objective: This study analyzed trends in research activity as represented in the published research in the leading peer-reviewed professional journal for health sciences librarianship. Methodology: Research articles were identified from the Bulletin of the Medical Library Association and Journal of the Medical Library Association (1991–2007). Using content analysis and bibliometric techniques, data were collected for each article on the (1) subject, (2) research method, (3) analytical technique used, (4) number of authors, (5) number of citations, (6) first author affiliation, and (7) funding source. The results were compared to a previous study, covering the period 1966 to 1990, to identify changes over time. Results: Of the 930 articles examined, 474 (51%) were identified as research articles. Survey (n = 174, 37.1%) was the most common methodology employed, quantitative descriptive statistics (n = 298, 63.5%) the most used analytical technique, and applied topics (n = 332, 70%) the most common type of subject studied. The majority of first authors were associated with an academic health sciences library (n = 264, 55.7%). Only 27.4% (n = 130) of studies identified a funding source. Conclusion: This study's findings demonstrate that progress is being made in health sciences librarianship research. There is, however, room for improvement in terms of research methodologies used, proportion of applied versus theoretical research, and elimination of barriers to conducting research for practicing librarians. PMID:19626146

  1. Opportunities in multi dimensional trace metal imaging: Taking copper associated disease research to the next level

    PubMed Central

    Vogt, Stefan; Ralle, Martina

    2012-01-01

    Copper plays an important role in numerous biological processes across all living systems predominantly because of its versatile redox behavior. Cellular copper homeostasis is tightly regulated and disturbances lead to severe disorders such as Wilson disease (WD) and Menkes disease. Age related changes of copper metabolism have been implicated in other neurodegenerative disorders such as Alzheimer’s disease (AD). The role of copper in these diseases has been topic of mostly bioinorganic research efforts for more than a decade, metal-protein interactions have been characterized and cellular copper pathways have been described. Despite these efforts, crucial aspects of how copper is associated with AD, for example, is still only poorly understood. To take metal related disease research to the next level, emerging multi dimensional imaging techniques are now revealing the copper metallome as the basis to better understand disease mechanisms. This review will describe how recent advances in X-ray fluorescence microscopy and fluorescent copper probes have started to contribute to this field specifically WD and AD. It furthermore provides an overview of current developments and future applications in X-ray microscopic methodologies. PMID:23079951

  2. American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome.

    PubMed

    Semenkovich, Clay F; Danska, Jayne; Darsow, Tamara; Dunne, Jessica L; Huttenhower, Curtis; Insel, Richard A; McElvaine, Allison T; Ratner, Robert E; Shuldiner, Alan R; Blaser, Martin J

    2015-12-01

    From 27-29 October 2014, more than 100 people gathered in Chicago, IL, to participate in a research symposium titled "Diabetes and the Microbiome," jointly sponsored by the American Diabetes Association and JDRF. The conference brought together international scholars and trainees from multiple disciplines, including microbiology, bioinformatics, endocrinology, metabolism, and immunology, to share the current understanding of host-microbe interactions and their influences on diabetes and metabolism. Notably, this gathering was the first to assemble specialists with distinct expertise in type 1 diabetes, type 2 diabetes, immunology, and microbiology with the goal of discussing and defining potential pathophysiologies linking the microbiome and diabetes. In addition to reviewing existing evidence in the field, speakers presented their own original research to provide a comprehensive view of the current understanding of the topics under discussion.Presentations and discussions throughout the conference reflected a number of important concepts. The microbiota in any host represent a complex ecosystem with a high degree of interindividual variability. Different microbial communities, comprising bacteria, archaea, viruses, and fungi, occupy separate niches in and on the human body. Individually and collectively, these microbes provide benefits to the host-including nutrient harvest from food and protection against pathogens. They are dynamically regulated by both host genes and the environment, and they critically influence both physiology and lifelong health. The objective of the symposium was to discuss the relationship between the host and the microbiome-the combination of microbiota and their biomolecular environment and ecology-specifically with regard to metabolic and immunological systems and to define the critical research needed to understand and potentially target the microbiome in the prevention and treatment of diabetes. In this report, we present meeting

  3. Digitization as a Method of Preservation? Final Report of a Working Group of the Deutsche Forschungsgemeinschaft (German Research Association).

    ERIC Educational Resources Information Center

    Weber, Hartmut; Dorr, Marianne

    The German Research Association (DFG) is actively involved in preservation of research materials; it takes the view that in preservation, the enormous potential of digitization for access should be combined with the stability of microfilm for long-term storage. A working group was convened to investigate the technical state of digitization of…

  4. North East Association for Institutional Research Annual Conference Proceedings (29th, Annapolis, Maryland, November 16-19, 2002).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    This proceedings contains papers from the 2002 annual conference of the Northeast Association for Institutional Research, a meeting devoted to assessment in the 21st century and the challenges that face institutional research. The papers are: (1) "Putting Community College Enrollment Trends in Perspective by the Use of Census Data and Market…

  5. ARL Preservation Statistics, 1997-98: A Compilation of Statistics from the Members of the Association of Research Libraries.

    ERIC Educational Resources Information Center

    Blixrud, Julia C., Comp.; Hipps, Kaylyn, Comp.; Kyrillidou, Martha, Comp.; O'Connor, Michael, Comp.

    This document presents data from 118 U.S. and Canadian research libraries that were members of the Association of Research Libraries (ARL) during the 1997-98 fiscal year. Since 1987-88, the number of preservation programs managed by a preservation administrator has grown irregularly from 66 to around 80 in more recent years. A fluctuating growth…

  6. The Barriers to Achieving the Wider Goals of General Education and Their Implications for the British Educational Research Association.

    ERIC Educational Resources Information Center

    Raven, John

    1990-01-01

    Advocates revamping the British educational system from technical-rational content model to student-centered process programs designed to promote critical thinking, individual initiative, and communication skills. Discusses obstacles to this educational reform, emphasizing research orientation. Urges the British Educational Research Association to…

  7. ARL Preservation Statistics, 2001-02. A Compilation of Statistics from the Members of the Association of Research Libraries

    ERIC Educational Resources Information Center

    Young, Mark, Comp.; Kyrillidou, Martha, Comp.

    2003-01-01

    This document presents data from 124 U.S. and Canadian research libraries that were members of the Association of Research Libraries (ARL) during the 2001-2002 fiscal year. Since 1987-1988, the number of preservation programs managed by a preservation administrator has grown irregularly from 66 to around 80 in more recent years. A fluctuating…

  8. Association Reports: Council on Undergraduate Research: An Investment in Tomorrow: Undergraduate Research Students Meet Members of Congress

    NASA Astrophysics Data System (ADS)

    Halstead, Judith A.

    1997-08-01

    This past April 10th, 58 college and university students met Members of Congress and their staffs at the first Undergraduate Research Poster Session on Capitol Hill sponsored by the Council on Undergraduate Research (CUR). These students represented 46 institutions of higher learning in 31 states, from as far away as California and Alaska to as near as Virginia and Maryland.

  9. The Evolving Landscape of Healthcare-Associated Infections: Recent Advances in Prevention and a Road Map for Research

    PubMed Central

    Safdar, Nasia; Anderson, Deverick J.; Braun, Barbara I.; Carling, Philip; Cohen, Stuart; Donskey, Curtis; Drees, Marci; Harris, Anthony; Henderson, David K.; Huang, Susan S.; Juthani-Mehta, Manisha; Lautenbach, Ebbing; Linkin, Darren R.; Meddings, Jennifer; Miller, Loren G.; Milstone, Aaron; Morgan, Daniel; Sengupta, Sharmila; Varman, Meera; Yokoe, Deborah; Zerr, Danielle M.

    2014-01-01

    This white paper identifies knowledge gaps and new challenges in healthcare epidemiology research, assesses the progress made toward addressing research priorities, provides the Society for Healthcare Epidemiology of America (SHEA) Research Committee’s recommendations for high-priority research topics, and proposes a road map for making progress toward these goals. It updates the 2010 SHEA Research Committee document, “Charting the Course for the Future of Science in Healthcare Epidemiology: Results of a Survey of the Membership of SHEA,” which called for a national approach to healthcare-associated infections (HAIs) and a prioritized research agenda. This paper highlights recent studies that have advanced our understanding of HAIs, the establishment of the SHEA Research Network as a collaborative infrastructure to address research questions, prevention initiatives at state and national levels, changes in reporting and payment requirements, and new patterns in antimicrobial resistance. PMID:24709716

  10. The European Safeguards Research and Development Association Addresses Safeguards and Nonproliferation

    SciTech Connect

    Janssens-Maenhout, Greet; Kusumi, R.; Daures, Pascal A.; Janssens, Willem; Dickman, Deborah A.

    2010-06-16

    The renaissance of efforts to expand the use of nuclear energy requires the parallel development of a renewed and more sophisticated work force. Growth in the nuclear sector with high standard of safety, safeguards and security requires skilled staff for design, operations, inspections etc. High-quality nuclear technology educational programs are diminished from past years, and the ability of universities to attract students and to meet future staffing requirements of the nuclear industry is becoming seriously compromised. Thus, education and training in nuclear engineering and sciences is one of the cornerstones for the nuclear sector. Teaching in the nuclear field still seems strongly influenced by national history but it is time to strengthen resources and collaborate. Moreover with the current nuclear security threats it becomes critical that nuclear technology experts master the basic principles not only of safety, but also of nuclear safeguards, nonproliferation and nuclear security. In Europe the European Nuclear Education Network (ENEN) Association has established the certificate 'European Master of Science in Nuclear Engineering (EMSNE)' as the classic nuclear engineering program covering reactor operation and nuclear safety. However, it does not include courses on nonproliferation, safeguards, or dual-use technologies. The lack of education in nuclear safeguards was tackled by the European Safeguards Research and Development Association (ESARDA), through development and implementation of safeguards course modules. Since 2005 the ESARDA Working Group, called the Training and Knowledge Management Working Group, (TKMWG) has worked with the Joint Research Centre (JRC) in Ispra, Italy to organize a Nuclear Safeguards and Nonproliferation course. This five-day course is held each spring at the JRC, and continues to show increasing interest as evidenced by the positive responses of international lecturers and students. The standard set of lectures covers a broad

  11. Minerals associated with biofilms occurring on exposed rock in a granitic underground research laboratory.

    PubMed

    Brown, D A; Kamineni, D C; Sawicki, J A; Beveridge, T J

    1994-09-01

    The concept of disposal of nuclear fuel waste in crystalline rock requires the effects of microbial action to be investigated. The Underground Research Laboratory excavated in a pluton of the Canadian Shield provides a unique opportunity to study these effects. Three biofilms kept moist by seepage through fractures in granitic rock faces of the Underground Research Laboratory have been examined. The biofilms contained a variety of gram-negative and gram-positive morphotypes held together by an organic extracellular matrix. Nutrient levels in the groundwater were low, but energy-dispersive X-ray spectroscopy has shown biogeochemical immobilization of several elements in the biofilms; some of these elements were concentrated from extremely dilute environmental concentrations, and all elements were chemically complexed together to form amorphous or crystalline fine-grained minerals. These were seen by transmission electron microscopy to be both associated with the surfaces of the bacteria and scattered throughout the extracellular matrix, suggesting their de novo development through bacterial surface-mediated nucleation. The biofilm consortia are thought to concentrate elements both by passive sorption and by energy metabolism. By Mössbauer spectroscopy and X-ray diffraction, one of the biofilms showed that iron was both oxidized and precipitated as ferrihydrite or hematite aerobically and reduced and precipitated as siderite anaerobically. We believe that some Archean banded-iron formations could have been formed in a manner similar to this, as it would explain the deposition of hematite and siderite in close proximity. This biogeochemical development of minerals may also affect the transport of material in waste disposal sites. PMID:16349374

  12. Systematic Review: The Association and Impact of Financial Conflicts of Interest in Basic Science Research

    PubMed Central

    Bennett, Charles L.; Boyle, Simone N.; Kuykendal, Adam; Fisher, Matthew J.; Samaras, Athena T.; Barnato, Sara E.; Wagner, Robin L.; Goldstein, Carolyn E.; Tallman, Jacob; Munshi, Hidayatullah G.; Lai, Stephen Y.; Henke, Michael

    2009-01-01

    Background No prior study has evaluated financial relationships of investigators with pharmaceutical manufacturers for basic science. An example of the importance and impact of such relationships is in the evaluation of erythropoietin receptors’(EpoRs) effects on cancer cell lines, since studies have reported increased mortality when cancer patients receive erythropoiesis stimulating agents (ESAs). Purpose To assess the disclosed association that exist between pharmaceutical industry support and EpoRs effects on solid cancer cell lines. Data Sources MEDLINE and EMBASE (1988- July 2008) and two EpoR conferences sponsored by the National Institutes of Health. Study Selection All publications investigating EpoRs that met inclusion criteria were identified and included. Data Extraction Data were extracted on detection of EpoRs, presence of erythropoietin-induced signaling events, presence of erythropoietin-induced changes in cellular function, nature of qualitative conclusions, and sources of funding for all 74 studies. Data Synthesis In comparison to studies of academic investigators with no disclosed funding support from ESA manufacturers (n=64), the studies from academic investigators with funding support from ESA manufacturers (n= 7) and the laboratories directed by investigators employed by ESA manufacturers (n=3) were both less likely to identify: EpoR presence on solid tumor cells; erythropoietin-induced signaling events; erythropoietin-induced changes in cellular function; and less likely to conclude that their research had identified potentially harmful effects of erythropoietin on cancer cells. Additionally, presentations from industry-based investigator teams at NIH conferences were less likely to report EpoRs on cancer cell lines, downstream effects of erythropoietin, and cell proliferation and migration effects following EpoR administration. Conclusion Financial conflicts of interest impact the outcomes and presentation of basic science research data as

  13. Minerals associated with biofilms occurring on exposed rock in a granitic underground research laboratory.

    PubMed

    Brown, D A; Kamineni, D C; Sawicki, J A; Beveridge, T J

    1994-09-01

    The concept of disposal of nuclear fuel waste in crystalline rock requires the effects of microbial action to be investigated. The Underground Research Laboratory excavated in a pluton of the Canadian Shield provides a unique opportunity to study these effects. Three biofilms kept moist by seepage through fractures in granitic rock faces of the Underground Research Laboratory have been examined. The biofilms contained a variety of gram-negative and gram-positive morphotypes held together by an organic extracellular matrix. Nutrient levels in the groundwater were low, but energy-dispersive X-ray spectroscopy has shown biogeochemical immobilization of several elements in the biofilms; some of these elements were concentrated from extremely dilute environmental concentrations, and all elements were chemically complexed together to form amorphous or crystalline fine-grained minerals. These were seen by transmission electron microscopy to be both associated with the surfaces of the bacteria and scattered throughout the extracellular matrix, suggesting their de novo development through bacterial surface-mediated nucleation. The biofilm consortia are thought to concentrate elements both by passive sorption and by energy metabolism. By Mössbauer spectroscopy and X-ray diffraction, one of the biofilms showed that iron was both oxidized and precipitated as ferrihydrite or hematite aerobically and reduced and precipitated as siderite anaerobically. We believe that some Archean banded-iron formations could have been formed in a manner similar to this, as it would explain the deposition of hematite and siderite in close proximity. This biogeochemical development of minerals may also affect the transport of material in waste disposal sites.

  14. The role of Water Resources Users Associations in hydrological research: experiences from Lake Naivasha Basin, Kenya

    NASA Astrophysics Data System (ADS)

    Agol, D.

    2012-04-01

    This paper is based on recent studies in Lake Naivasha Basin that explored the ways in which locally based institutions namely the Water Resources Users Associations (WRUAs) are contributing to hydrological knowledge for decision-making processes. Lake Naivasha is a shallow freshwater body which is situated on the floor of Kenya's Rift Valley. It covers approximately 140 Km2 and supports a rich diversity of plants and animals. The Lake Naivasha Basin faces several challenges associated with over- population, urbanization and intensive agricultural activities. For example, the large-scale floricultural and horticultural export industries around the Lake have attracted thousands of migrants from different parts of Kenya who have settled around the Lake and exert a lot of pressure on its resources. The Lake Naivasha is one of the best examples in Kenya where the WRUAs development process has shown some progress. There are 12 WRUAS across the Lake Basin representing its various sub-catchments. In recent years, the role of WRUAs in the Lake has changed rapidly as they are no longer restricted to just resolving conflicts and fostering cooperation between water users. They now have an additional responsibility of collecting hydrological data within their respective sub-catchments. The majority of WRUA officials have been trained on how to collect data such as reading rain gauges, measuring stream flows, turbidity and sediment loads. The data collected are sent to the relevant government authorities for validation and interpretation and the information derived from this process is used to formulate important strategies such as water allocation plans. Using secondary data analysis, interviews and focus group discussions the study investigated how this new role of the WRUAs is changing the water resource management landscape in the Lake Naivasha Basin. In particular it presents key challenges and opportunities associated with attempts to build capacities of lower level

  15. Tobacco and cancer: an American Association for Cancer Research policy statement.

    PubMed

    Viswanath, Kasisomayajula; Herbst, Roy S; Land, Stephanie R; Leischow, Scott J; Shields, Peter G

    2010-05-01

    The evidence against tobacco use is clear, incontrovertible, and convincing; so is the need for urgent and immediate action to stem the global tide of tobacco-related death and suffering and to improve public health. The American Association for Cancer Research makes an unequivocal call to all who are concerned about public health to take the following immediate steps:Increase the investment in tobacco-related research, commensurate with the enormous toll that tobacco use takes on human health, to provide the scientific evidence to drive the development of effective policies and treatments necessary to dramatically reduce tobacco use and attendant disease. Develop new evidence-based strategies to more effectively prevent the initiation of tobacco use, especially for youth and young adults. Promote the further development of evidence-based treatments for tobacco cessation, including individualized therapies, and ensure coverage of and access to evidence-based behavioral and pharmacological treatments. Develop evidence-based strategies for more effective public communication to prevent, reduce, and eliminate tobacco use and to guide health policies and clinical practice. Develop effective, evidence-based policies to reduce disparities across the tobacco continuum among social groups and developed and developing nations. Implement to the fullest extent existing evidence-based, systems-wide tobacco control programs to prevent initiation and foster cessation. Adapt and implement appropriate approaches to reduce the growing burden of tobacco use in the developing world. Enhance and coordinate surveillance efforts, both in the United States and globally, to monitor tobacco products, tobacco use, and tobacco-related disease, including tobacco use in oncology clinical trials. Establish a comprehensive, science-based regulatory framework to evaluate tobacco products and manufacturers' claims. Promote research that addresses the following: the potential harms of current and

  16. Global positioning system and associated technologies in animal behaviour and ecological research

    PubMed Central

    Tomkiewicz, Stanley M.; Fuller, Mark R.; Kie, John G.; Bates, Kirk K.

    2010-01-01

    Biologists can equip animals with global positioning system (GPS) technology to obtain accurate (less than or equal to 30 m) locations that can be combined with sensor data to study animal behaviour and ecology. We provide the background of GPS techniques that have been used to gather data for wildlife studies. We review how GPS has been integrated into functional systems with data storage, data transfer, power supplies, packaging and sensor technologies to collect temperature, activity, proximity and mortality data from terrestrial species and birds. GPS ‘rapid fixing’ technologies combined with sensors provide location, dive frequency and duration profiles, and underwater acoustic information for the study of marine species. We examine how these rapid fixing technologies may be applied to terrestrial and avian applications. We discuss positional data quality and the capability for high-frequency sampling associated with GPS locations. We present alternatives for storing and retrieving data by using dataloggers (biologging), radio-frequency download systems (e.g. very high frequency, spread spectrum), integration of GPS with other satellite systems (e.g. Argos, Globalstar) and potential new data recovery technologies (e.g. network nodes). GPS is one component among many rapidly evolving technologies. Therefore, we recommend that users and suppliers interact to ensure the availability of appropriate equipment to meet animal research objectives. PMID:20566494

  17. Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD

    PubMed Central

    Inagaki, Takeshi

    2015-01-01

    Fibroblast growth factor 21 (FGF21) is a metabolic hormone primarily secreted from the liver and functions in multiple tissues. Various transcription factors induce FGF21 expression in the liver, which indicates that FGF21 is a mediator of multiple environmental cues. FGF21 alters metabolism under starvation conditions, protects the body from energy depletion, and extends life span. Pharmacological administration of FGF21 alleviates dyslipidemia and induces weight loss in obese animals. In addition to the well-studied functions of FG21, several lines of recent evidence indicate a possible link between FGF21 and non-alcoholic fatty liver disease (NAFLD). High serum levels of FGF21 are associated with NAFLD and its risk factors, such as endoplasmic reticulum stress and chronic inflammation. In addition, FGF21 alleviates the major risk factors of NAFLD, including obesity, dyslipidemia, and insulin insensitivity. Thus, FGF21 is a potential drug candidate for diseases, such as NAFLD, dyslipidemia, and type 2 diabetes. In this review, the research perspectives of FGF21 and therapeutic potencies of FGF21 as a modulator of NAFLD are summarized. PMID:26441837

  18. Global positioning system and associated technologies in animal behaviour and ecological research

    USGS Publications Warehouse

    Tomkiewicz, Stanley M.; Fuller, Mark R.; Kie, John G.; Bates, Kirk K.

    2010-01-01

    Biologists can equip animals with global positioning system (GPS) technology to obtain accurate (less than or equal to 30 m) locations that can be combined with sensor data to study animal behaviour and ecology. We provide the background of GPS techniques that have been used to gather data for wildlife studies. We review how GPS has been integrated into functional systems with data storage, data transfer, power supplies, packaging and sensor technologies to collect temperature, activity, proximity and mortality data from terrestrial species and birds. GPS 'rapid fixing' technologies combined with sensors provide location, dive frequency and duration profiles, and underwater acoustic information for the study of marine species. We examine how these rapid fixing technologies may be applied to terrestrial and avian applications. We discuss positional data quality and the capability for high-frequency sampling associated with GPS locations. We present alternatives for storing and retrieving data by using dataloggers (biologging), radio-frequency download systems (e.g. very high frequency, spread spectrum), integration of GPS with other satellite systems (e.g. Argos, Globalstar) and potential new data recovery technologies (e.g. network nodes). GPS is one component among many rapidly evolving technologies. Therefore, we recommend that users and suppliers interact to ensure the availability of appropriate equipment to meet animal research objectives.

  19. Arts and Learning Research, 1998-1999. The Journal of the Arts and Learning Special Interest Group of the American Educational Research Association (Chicago, Illinois, April 1998).

    ERIC Educational Resources Information Center

    Bresler, Liora, Ed.; Ellis, Nancy C., Ed.

    1999-01-01

    This volume highlights thought-provoking issues in visual arts, drama, and music education presented at the 1998 meeting of the American Educational Research Association. Following a message from the Special Interest Group Chair, Larry Kantner, and an editorial, articles in section 1 are: "Art Beginnings" (L. A. Kantner); "Teachers' Conceptions of…

  20. Bridges to the Future: Building Linkages for Institutional Research. North East Association for Institutional Research Annual Conference Proceedings (27th, Pittsburgh, PA, November 4-7, 2000).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    This document contains papers, summaries of panel presentations, and work share meetings from the annual conference of the North East Association for Institutional Research. The papers are: (1) "The Influence of Personality Traits, Pre-College Characteristics, and Co-Curricular Experiences on College Outcomes" (Karen W. Bauer); (2) "Threading the…

  1. Factors Associated with Research Productivity among Oral Healthcare Educators in an Asian University

    ERIC Educational Resources Information Center

    Bay, Bernardo E., Jr.; Clerigo, Maria Eloisa C.

    2013-01-01

    Research writing confidence and organizational support toward research activities are two essential factors that may affect research productivity among higher educational institutions. This study investigated the possible relationships of these two factors to research productivity among faculty members of the College of Dentistry at Lyceum of the…

  2. National Association and Organization Reports. American Library Association; Association of American Publishers; American Booksellers Association; Association of Research Libraries; Scholarly Publishing and Academic Resources Coalition (SPARC); Council on Library and Information Resources.

    ERIC Educational Resources Information Center

    Freedman, Maurice J.; Platt, Judith; Hoynes, Michael; Webster, Duane E.; Johnson, Richard; Smith, Kathlin

    2003-01-01

    Includes six reports from national associations and organizations. Highlights include annual meetings; government affairs; copyright; administration; diversity; new technologies; international programs; scholarly communication; information policy; access to information; preservation; statistics and measurement; digital libraries; economics of…

  3. The International Permafrost Association: new structure and initiatives for cryospheric research

    NASA Astrophysics Data System (ADS)

    May, I.; Lewkowicz, A. G.; Christiansen, H.; Romanovsky, V. E.; Lantuit, H.; Schrott, L.; Sergeev, D.; Wei, M.

    2012-12-01

    The International Permafrost Association (IPA), founded in 1983, has as its objectives to foster the dissemination of knowledge concerning permafrost and to promote cooperation among persons and national or international organizations engaged in scientific investigation and engineering work on permafrost. The IPA's primary responsibilities are convening International Permafrost Conferences, undertaking special projects such as preparing databases, maps, bibliographies, and glossaries, and coordinating international field programs and networks. Membership is through adhering national or multinational organizations or as individuals in countries where no Adhering Body exists. The IPA is governed by its Executive Committee and a Council consisting of representatives from 26 Adhering Bodies having interests in some aspect of theoretical, basic and applied frozen ground research, including permafrost, seasonal frost, artificial freezing and periglacial phenomena. This presentation details recent and ongoing changes in the functioning of the IPA that will influence the way cryospheric research is conducted under its auspices. One of the most important is the development of competitively-funded Action Groups which work towards the production of well-defined products over a period of two years. Since the first call, four proposals have been accepted by the Executive Committee and the teams are currently working on high topical issues, such as the assessment of the deep permafrost organic carbon pools and the mapping of subsea permafrost, as well as fundamental questions such as the extent of permafrost during the Last Permafrost Maximum. The IPA also decided to put additional effort into facilitating the study of the significance of permafrost to the global climate systems, with human aspects playing a very important role. To achieve this goal, the IPA will encourage and assist the climate modeling community in improving the representation of perennially frozen ground

  4. Factors associated with biosafety level-2 research workers' laboratory exit handwashing behaviors and glove removal compliance.

    PubMed

    Johnston, James D; Merrill, Ray M; Zimmerman, Grant C; Collingwood, Scott C; Reading, James C

    2016-01-01

    Biosafety level-2 laboratories are designated for work with human-derived samples or moderate-risk microorganisms that transmit primarily by direct contact exposures. Many laboratory procedures generate unseen droplets that contaminate workers' hands, equipment, and work surfaces. Workers' strict adherence to glove removal and handwashing is required prior to laboratory exit to prevent inadvertent transmission of pathogens to self or others. However, little is known about biosafety level-2 workers' compliance with these behaviors. In this article, glove removal and handwashing compliance upon laboratory exit were measured by direct observation of 93 biosafety level-2 research workers from 21 university laboratories. Participants completed a 41-item survey measuring social cognitive theory-based variables related to handwashing, self-reported compliance, and demographic factors. Survey items, observed exit frequency, and laboratory characteristics were evaluated for associations with handwashing compliance. Overall, observed glove removal and handwashing compliance upon laboratory exit were 43.0% (Standard Error [SE] = 2.3%), and 8.2% (SE = 1.2%), respectively, while workers' self-reported glove removal and handwashing compliance were 73.7% (SE = 3.6%) and 35.5% (SE = 4.1%), respectively. The average number of observed laboratory exits per hour was 2.8 for workers with any handwashing compliance vs. 5.4 for workers with no handwashing compliance (p = 0.0013). Among the cognitive variables, behavioral modeling by supervisors and coworkers had the strongest association with workers' compliance (slope = 3.5, SE = 1.3, p = 0.0113). Workers in laboratories with a written handwashing policy had higher compliance (Mean = 14.1%, SE = 5.9%) than workers in laboratories with no written policy (Mean = 1.1%, SE = 1.0%; p = 0.0488). Multi-faceted interventions that encourage modeling of the behavior by supervisors and coworkers, implementation of written handwashing policies

  5. SU-E-T-317: The Development of a DIBH Technique for Left Sided Breast Patients Undergoing Radiation Therapy Utilizing Varians RPM System in a Community Hospital

    SciTech Connect

    Hasson, B; Young, M; Workie, D; Geraghty, C

    2014-06-01

    Purpose: To develop and implement a Deep Inhalation Breath Hold program (DIBH) for treatment of patients with Left-sided breast cancer in a community hospital. Methods: All patients with left sided breast cancer underwent a screening free breathing CT. Evaluation of the conventional tangent treatment fields and the heart was conducted. If the heart would not be excluded using tangents, the patient then received DIBH breathe coaching. The patients returned for a 4D CT simulation. The patients breathing cycle was monitored using the Varian Real-Time position ManagementTM (RPM) system to assess duration of DIBH, amplitude, phase and recovery time to normal breathing. Then a DIBH CT was obtained at the desired amplitude. Duplicate plans were developed for both free breathing and DIBH on the Eclipse planning system and comparison DVH's were created. The plan that provided the prescribed treatment coverage and the least doses to the OAR (heart, Lt. Lung) was determined. Those patients selected to receive treatment with DIBH were set up for treatment, and breathing was monitored using the RPM system. Practice trials were used to confirm that the amplitude, phase and recovery were consistent with findings from simulation. Results: 10 patients have been treated using the DIBH procedure in our clinic. The DIBH patients had an average increase of 80% lung volume on DIBH, decreased lung volume receiving 50% of the dose, and decreases in the V20 dose. Significant reduction in the maximum and mean dose to the heart, as well as the dose to 1CC of the volume for the DIBH plans. Conclusion: Using the RPM system already available in the clinic, staff training, and patient coaching a simple DIBH program was setup. The use of DIBH has shown promise in reducing doses to the critical organs while maintaining PTV coverage for left sided breast treatments.

  6. Reduction of the effect of non-uniform backscatter from an E-type support arm of a Varian a-Si EPID used for dosimetry

    NASA Astrophysics Data System (ADS)

    Rowshanfarzad, Pejman; Sabet, Mahsheed; O'Connor, Daryl J.; Greer, Peter B.

    2010-11-01

    Backscatter from the metallic components in the support arm is one of the sources of inaccuracy in dosimetry with Varian amorphous silicon electronic portal imaging devices (a-Si EPIDs). In this study, the non-uniform arm backscatter is blocked by adding lead sheets between the EPID and an E-type support arm. By comparing the EPID responses on and off the arm, with and without lead and considering the extra weight on the imager, 2 mm of lead was determined as the optimum thickness for both 6 and 18 MV beam energies. The arm backscatter at the central axis with the 2 mm lead in place decreased to 0.1% and 0.2% for the largest field size of 30 × 30 cm2 using 6 and 18 MV beams, from 2.3% and 1.3% without lead. Changes in the source-to-detector distance (SDD) did not affect the backscatter component more than 1%. The symmetry of the in-plane profiles improved for all field sizes for both beam energies. The addition of lead decreased the contrast-to-noise ratio and resolution by 1.3% and 0.84% for images taken in 6 MV and by 0.5% and 0.38% for those in 18 MV beams. The displacement of the EPID central pixel was measured during a 360° gantry rotation with and without lead which was 1 pixel different. While the backscatter reduces with increasing lead thickness, a 2 mm lead sheet seems sufficient for acceptable dosimetry results without any major degradation to the routine performance of the imager. No increase in patient skin dose was detected.

  7. Commissioning and validation of BrainLAB cones for 6X FFF and 10X FFF beams on a Varian TrueBeam STx.

    PubMed

    Wiant, David B; Terrell, Jonathon A; Maurer, Jacqueline M; Yount, Caroline L; Sintay, Benjamin J

    2013-11-04

    Small field dosimetry is a challenging task. The difficulties of small field measurements, particularly stereotactic field size measurements, are highlighted by the large interinstitution variability that can be observed for circular cone collimator commissioning measurements. We believe the best way to improve the consistency of small field measurements is to clearly document and share the results of small field measurements. In this work we report on the commissioning and validation of a BrainLAB cone system for 6 MV and 10 MV flattening filter-free (FFF) beams on a Varian TrueBeam STx. Commissioning measurements consisted of output factors, percent depth dose, and off-axis factor measurements with a diode. Validation measurements were made in a polystyrene slab phantom at depths of 5 cm, 10 cm, and 15 cm using radiochromic film. Output factors for the 6xFFF cones are 0.689, 0.790, 0.830, 0.871, 0.890, and 0.901 for 4 mm, 6 mm, 7.5 mm, 10 mm, 12.5 mm, and the 15 mm cones, respectively. Output factors for the 10xFFF cones are 0.566, 0.699, 0.756, 0.826, 0.864, and 0.888 for 4 mm, 6 mm, 7.5 mm, 10 mm, 12.5 mm, and the 15 mm cones, respectively. The full width half maximum values of the off-axis factors agreed with the nominal cone size to within 0.5 mm. Validation measurements showed an agreement of absolute dose between calculation and plan of < 3.6%, and an agreement of field sizes of ≤ 0.3 mm in all cases. Radiochromic film validation measurements show reasonable agreement with beam models for circular collimators based on diode commissioning measurements.

  8. SU-E-J-11: Measurement of Eye Lens Dose for Varian On-Board Imaging with Different CBCT Acquisition Techniques

    SciTech Connect

    Deshpande, S; Dhote, D; Kumar, R; Thakur, K

    2015-06-15

    Purpose: To measure actual patient eye lens dose for different cone beam computed tomography (CBCT) acquisition protocol of Varian’s On Board Imagining (OBI) system using Optically Stimulated Luminescence (OSL) dosimeter and study the eye lens dose with patient geometry and distance of isocenter to the eye lens Methods: OSL dosimeter was used to measure eye lens dose of patient. OSL dosimeter was placed on patient forehead center during CBCT image acquisition to measure eye lens dose. For three different cone beam acquisition protocol (standard dose head, low dose head and high quality head) of Varian On-Board Imaging, eye lens doses were measured. Measured doses were correlated with patient geometry and distance between isocenter to eye lens. Results: Measured eye lens dose for standard dose head was in the range of 1.8 mGy to 3.2 mGy, for high quality head protocol dose was in range of 4.5mGy to 9.9 mGy whereas for low dose head was in the range of 0.3mGy to 0.7mGy. Dose to eye lens is depends upon position of isocenter. For posterioraly located tumor eye lens dose is less. Conclusion: From measured doses it can be concluded that by proper selection of imagining protocol and frequency of imaging, it is possible to restrict the eye lens dose below the new limit set by ICRP. However, undoubted advantages of imaging system should be counter balanced by careful consideration of imaging protocol especially for very intense imaging sequences for Adoptive Radiotherapy or IMRT.

  9. Priorities for mental health research in Europe: A survey among national stakeholders' associations within the ROAMER project

    PubMed Central

    Fiorillo, Andrea; Luciano, Mario; Del Vecchio, Valeria; Sampogna, Gaia; Obradors-Tarragó, Carla; Maj, Mario

    2013-01-01

    Within the ROAMER project, funded by the European Commission, a survey was conducted with national associations/organizations of psychiatrists, other mental health professionals, users and/or carers, and psychiatric trainees in the 27 countries of the European Union, aiming to explore their views about priorities for mental health research in Europe. One hundred and eight associations/organizations returned the questionnaire. The five most frequently selected research priorities were early detection and management of mental disorders, quality of mental health services, prevention of mental disorders, rehabilitation and social inclusion, and new medications for mental disorders. All these areas, except the last one, were among the top ten research priorities according to all categories of stakeholders, along with stigma and discrimination. These results seem to support the recent argument that some rebalancing in favor of psychosocial and health service studies may be needed in psychiatric research. PMID:23737426

  10. Entertainers or Education Researchers? The Challenges Associated with Presenting While Black

    ERIC Educational Resources Information Center

    McGee, Ebony O.; Kazembe, Lasana

    2016-01-01

    How black faculty experience presenting their research in educational venues within the context of historical objectification of black people as sources of entertainment is an underexplored topic in higher education research. Presenting research has far-reaching implications for black academics' advancement, such as future employment and…

  11. National University Consortium on Microwave Research (NUCOMR)

    NASA Astrophysics Data System (ADS)

    Barker, Robert J.; Agee, Forrest J.

    1995-09-01

    This paper introduces a new cooperative research program of national scale that is focused on crucial research issues in the development of high energy microwave sources. These have many applications in the DOD and industry. The Air Force Office of Scientific Research (AFOSR), in coopertaion with the Phillips Laboratory, the Naval Research Laboratory, and the Army Research Laboratory, has established a tri-service research consortium to investigate novel high energy microwave sources. The program is part of the DODs 'Multidisciplinary University Research Initiative' and will be funded at a rate of $DLR3.0M per year for up to five years. All research performed under this program will be unclassified. Under its auspices, HPM scientists at nine US universities will be attacking twenty-two separate research projects under the leadership of Neville Luhmann at UC-Davis, Victor Granatstein at Maryland, Magne Kristiansen at Texas Tech, Edl Schamiloglu at New Mexico, John Nation at Cornell, Ned Birdsall at UC-Berkeley, George Caryotakis at Standord, Ronald Gilgenbach at Michigan, and Anthony Lin at UCLA. To facilitate the rapid transition of research results into the industrial community, formal collaborative subcontracts are already in place with James Benford at Physics International, Carter Armstrong at Northrop, and Glen Huffman at Varian Associates. Although this new program officially only came into existence in mid-March of this year, it builds on over a decade of microwave research efforts funded by the plasma physics office at AFOSR. It also is synergistic with the ongoing Tri-Service Vacuum Electronics Initiative led by Robert Parker of NRL as well as with the AFOSR's and Rome Laboratory's long standing Advanced Thermionic Research Initiative. An overview will be given of the broad spectrum of research objectives encompassed by NUCOMR. Areas of collaboration and technology transfer will be highlighted. The areas in which the three university consortia will conduct

  12. Future Research, Research Futures. Proceedings of the National Conference of the Australian Vocational Education and Training Research Association (AVETRA) (3rd, Canberra, Australia, March 23-24, 2000).

    ERIC Educational Resources Information Center

    Australian Vocational Education and Training Research Association, Alexandria.

    These proceedings consist of 66 conference papers on these themes: changing nature of work; emerging technologies; internationalization of vocational education and training (VET); enterprise and educational innovation; flexible delivery approaches; and research and technology and using technology in research. The papers are "Training Needs of…

  13. Research and Development for a Course in Ethics in Nursing Practice for Community College Associate Degree Nursing Students. Final Report.

    ERIC Educational Resources Information Center

    Roediger, Jeanette

    A project was undertaken to research and acquire the instructional sources needed for a course in ethics for community college associate degree nursing students and to develop such a course. Addressed in the individual units of the course were the following topics: bioethics and ethical decision making, basic ethical concepts and principles,…

  14. Organizational and Institutional Factors Associated with National Institutes of Health Research Grant Awards to Social Work Programs

    ERIC Educational Resources Information Center

    Corvo, Kenneth; Zlotnik, Joan; Chen, Wan-Yi

    2008-01-01

    This study examines the organizational and institutional factors that may be associated with the success of schools of social work (SOSWs) in securing research grant awards from the National Institutes of Health (NIH) and constituent agencies. Using data from the CRISP database on NIH grant funding, the Lombardi Program on Measuring University…

  15. Literacy Promises. The Thirty-Third Yearbook: A Doubled Peer Reviewed Publication of the Association of Literacy Educators and Researchers

    ERIC Educational Resources Information Center

    Morrison, Timothy, Ed.; Martin, Linda, Ed.; Boggs, Merry, Ed.; Szabo, Susan, Ed.; Haas, Leslie, Ed.

    2011-01-01

    For its 54th annual meeting, the Association of Educators and Researchers met in Omaha, Nebraska at the Hilton Omaha. This year's conference theme was "Literacy Promises", which was also used as the title for this year's Yearbook, Volume 33. This organization has long been the home of some of the nation's most notable literacy experts. At the…

  16. ARL Supplementary Statistics, 2001-02. A Compilation of Statistics from the Members of the Association of Research Libraries

    ERIC Educational Resources Information Center

    Young, Mark, Comp.; Kyrillidou, Martha, Comp.

    2003-01-01

    This report presents statistics on how Association of Research Libraries (ARL) member libraries spend money on electronic resources. This report indicates that expenditures for electronic resources account for 19.6%, on average, of ARL institutions' library materials budgets. ARL libraries reported spending more than $171 million on electronic…

  17. Statement of the American Sociological Association on the Importance of Collecting Data and Doing Social Scientific Research on Race.

    ERIC Educational Resources Information Center

    American Sociological Association, Washington, DC.

    This statement describes the basis for the American Sociological Association's (ASA) position regarding scientific research on race, illustrating the importance of such data to further scientific investigation and inform public policy. Race is a complex, sensitive, and controversial topic in scientific discourse and public policy. The controversy…

  18. Research among Learners of Chinese as a Foreign Language. Chinese Language Teachers Association Monograph Series. Volume IV

    ERIC Educational Resources Information Center

    Everson, Michael E., Ed.; Shen, Helen H., Ed.

    2010-01-01

    Cutting-edge in its approach and international in its authorship, this fourth monograph in a series sponsored by the Chinese Language Teachers Association features eight research studies that explore a variety of themes, topics, and perspectives important to a variety of stakeholders in the Chinese language learning community. Employing a wide…

  19. State Library Agencies and Member Libraries of the Association of Research Libraries. Final Report of Two Surveys.

    ERIC Educational Resources Information Center

    Chobot, Mary C.

    State Library Agencies (SLAs) and library members of the Association of Research Libraries (ARL) were surveyed to collect data from potential audiences for American Memory products to assist the planners for this Library of Congress (LC) project. This summary report briefly explains the purpose of the surveys; describes the survey methodology and…

  20. Association for Research in Vision and Ophthalmology (ARVO)--2010 Annual Meeting. For Sight: The Future of Eye and Vision Research--part 1.

    PubMed

    Hookes, Livia

    2010-07-01

    The 2010 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), held in Fort Lauderdale, FL, USA, included topics covering new therapeutic developments in the field of eye and vision research. This conference report highlights selected presentations on the development of FOV-2304 (Fovea Pharmaceuticals SA) for the potential treatment of diabetic macular edema; PHA-666859 (Pfizer Inc) for diabetic retinopathy; GTx-878 (GTx Inc) and FCFD-4514S (Genentech Inc) for age-related macular degeneration; SYL-040012 (Sylentis Sau) for ocular hypertension associated with open-angle glaucoma; PEG-PLA-TNP-470 (Harvard Medical School) for ocular neovascularization; recombinant galectin-3 (Senju Pharmaceutical Co Ltd) for corneal injury; and CellBead Neuro (CellMed Inc) for neurological trauma and neurodegeneration.

  1. Relationships Matter: Some Benefits, Challenges and Tensions Associated with Forming a Collaborative Educational Researcher Group

    ERIC Educational Resources Information Center

    Wong, Sandie; Murray, E.; Rivalland, C.; Monk, H.; Piazza-McFarland, L.; Daniel, G.

    2014-01-01

    Growing recognition of the complexity of children's lives has led to strong advocacy in education research literature for greater collaboration between researchers from different paradigms to address the "wicked" problems that face contemporary children and families. There is little literature, however, exploring how collaboration…

  2. Dealing with Data: Science Librarians' Participation in Data Management at Association of Research Libraries Institutions

    ERIC Educational Resources Information Center

    Antell, Karen; Foote, Jody Bales; Turner, Jaymie; Shults, Brian

    2014-01-01

    As long as empirical research has existed, researchers have been doing "data management" in one form or another. However, funding agency mandates for doing formal data management are relatively recent, and academic libraries' involvement has been concentrated mainly in the last few years. The National Science Foundation implemented a new…

  3. Directory of Human Sciences Research Organizations and Professional Associations in South Africa. Second Edition.

    ERIC Educational Resources Information Center

    van der Berg, Henda, Ed.; Prinsloo, Roelf, Ed.; Pienaar, Drienie, Ed.

    This directory is intended to be a comprehensive reference source for identifying research organizations and institutions, and for promoting research cooperation and facilitating networking. This second edition provides a broad background to the development of the human sciences as well as an overview of existing and emerging science and…

  4. SU-E-T-109: Development of An End-To-End Test for the Varian TrueBeamtm with a Novel Multiple-Dosimetric Modality H and N Phantom

    SciTech Connect

    Zakjevskii, V; Knill, C; Rakowski, J; Snyder, M

    2014-06-01

    Purpose: To develop a comprehensive end-to-end test for Varian's TrueBeam linear accelerator for head and neck IMRT using a custom phantom designed to utilize multiple dosimetry devices. Methods: The initial end-to-end test and custom H and N phantom were designed to yield maximum information in anatomical regions significant to H and N plans with respect to: i) geometric accuracy, ii) dosimetric accuracy, and iii) treatment reproducibility. The phantom was designed in collaboration with Integrated Medical Technologies. A CT image was taken with a 1mm slice thickness. The CT was imported into Varian's Eclipse treatment planning system, where OARs and the PTV were contoured. A clinical template was used to create an eight field static gantry angle IMRT plan. After optimization, dose was calculated using the Analytic Anisotropic Algorithm with inhomogeneity correction. Plans were delivered with a TrueBeam equipped with a high definition MLC. Preliminary end-to-end results were measured using film and ion chambers. Ion chamber dose measurements were compared to the TPS. Films were analyzed with FilmQAPro using composite gamma index. Results: Film analysis for the initial end-to-end plan with a geometrically simple PTV showed average gamma pass rates >99% with a passing criterion of 3% / 3mm. Film analysis of a plan with a more realistic, ie. complex, PTV yielded pass rates >99% in clinically important regions containing the PTV, spinal cord and parotid glands. Ion chamber measurements were on average within 1.21% of calculated dose for both plans. Conclusion: trials have demonstrated that our end-to-end testing methods provide baseline values for the dosimetric and geometric accuracy of Varian's TrueBeam system.

  5. SU-E-T-562: Scanned Percent Depth Dose Curve Discrepancy for Photon Beams with Physical Wedge in Place (Varian IX) Using Different Sensitive Volume Ion Chambers

    SciTech Connect

    Zhao, H; Sarkar, V; Rassiah-Szegedi, P; Huang, Y; Szegedi, M; Huang, L; Salter, B

    2014-06-01

    Purpose: To investigate and report the discrepancy of scanned percent depth dose (PDD) for photon beams with physical wedge in place when using ion chambers with different sensitive volumes. Methods/Materials: PDD curves of open fields and physical wedged fields (15, 30, 45, and 60 degree wedge) were scanned for photon beams (6MV and 10MV, Varian iX) with field size of 5x5 and 10x10 cm using three common scanning chambers with different sensitive volumes - PTW30013 (0.6cm3), PTW23323 (0.1cm3) and Exradin A16 (0.007cm3). The scanning system software used was OmniPro version 6.2, and the scanning water tank was the Scanditronix Wellhoffer RFA 300.The PDD curves from the three chambers were compared. Results: Scanned PDD curves of the same energy beams for open fields were almost identical between three chambers, but the wedged fields showed non-trivial differences. The largest differences were observed between chamber PTW30013 and Exradin A16. The differences increased as physical wedge angle increased. The differences also increased with depth, and were more pronounced for 6MV beam. Similar patterns were shown for both 5x5 and 10x10 cm field sizes. For open fields, all PDD values agreed with each other within 1% at 10cm depth and within 1.62% at 20 cm depth. For wedged fields, the difference of PDD values between PTW30013 and A16 reached 4.09% at 10cm depth, and 5.97% at 20 cm depth for 6MV with 60 degree physical wedge. Conclusion: We observed a significant difference in scanned PDD curves of photon beams with physical wedge in place obtained when using different sensitive volume ion chambers. The PDD curves scanned with the smallest sensitive volume ion chamber showed significant difference from larger chamber results, beyond 10cm depth. We believe this to be caused by varying response to beam hardening by the wedges.

  6. SU-E-J-28: Gantry Speed Significantly Affects Image Quality and Imaging Dose for 4D Cone-Beam Computed Tomography On the Varian Edge Platform

    SciTech Connect

    Santoso, A; Song, K; Gardner, S; Chetty, I; Wen, N

    2015-06-15

    Purpose: 4D-CBCT facilitates assessment of tumor motion at treatment position. We investigated the effect of gantry speed on 4D-CBCT image quality and dose using the Varian Edge On-Board Imager (OBI). Methods: A thoracic protocol was designed using a 125 kVp spectrum. Image quality parameters were obtained via 4D acquisition using a Catphan phantom with a gating system. A sinusoidal waveform was executed with a five second period and superior-inferior motion. 4D-CBCT scans were sorted into 4 and 10 phases. Image quality metrics included spatial resolution, contrast-to-noise ratio (CNR), uniformity index (UI), Hounsfield unit (HU) sensitivity, and RMS error (RMSE) of motion amplitude. Dosimetry was accomplished using Gafchromic XR-QA2 films within a CIRS Thorax phantom. This was placed on the gating phantom using the same motion waveform. Results: High contrast resolution decreased linearly from 5.93 to 4.18 lp/cm, 6.54 to 4.18 lp/cm, and 5.19 to 3.91 lp/cm for averaged, 4 phase, and 10 phase 4DCBCT volumes respectively as gantry speed increased from 1.0 to 6.0 degs/sec. CNRs decreased linearly from 4.80 to 1.82 as the gantry speed increased from 1.0 to 6.0 degs/sec, respectively. No significant variations in UIs, HU sensitivities, or RMSEs were observed with variable gantry speed. Ion chamber measurements compared to film yielded small percent differences in plastic water regions (0.1–9.6%), larger percent differences in lung equivalent regions (7.5–34.8%), and significantly larger percent differences in bone equivalent regions (119.1–137.3%). Ion chamber measurements decreased from 17.29 to 2.89 cGy with increasing gantry speed from 1.0 to 6.0 degs/sec. Conclusion: Maintaining technique factors while changing gantry speed changes the number of projections used for reconstruction. Increasing the number of projections by decreasing gantry speed decreases noise, however, dose is increased. The future of 4DCBCT’s clinical utility relies on further

  7. SU-E-J-155: Utilizing Varian TrueBeam Developer Mode for the Quantification of Mechanical Limits and the Simulation of 4D Respiratory Motion

    SciTech Connect

    Moseley, D; Dave, M

    2014-06-01

    Purpose: Use Varian TrueBeam Developer mode to quantify the mechanical limits of the couch and to simulate 4D respiratory motion. Methods: An in-house MATLAB based GUI was created to make the BEAM XML files. The couch was moved in a triangular wave in the S/I direction with varying amplitudes (1mm, 5mm, 10mm, and 50mm) and periods (3s, 6s, and 9s). The periods were determined by specifying the speed. The theoretical positions were compared to the values recorded by the machine at 50 Hz. HD videos were taken for certain tests as external validation. 4D Respiratory motion was simulated by an A/P MV beam being delivered while the couch moved in an elliptical manner. The ellipse had a major axis of 2 cm (S/I) and a minor axis of 1 cm (A/P). Results: The path planned by the TrueBeam deviated from the theoretical triangular form as the speed increased. Deviations were noticed starting at a speed of 3.33 cm/s (50mm amplitude, 6s period). The greatest deviation occurred in the 50mm- 3s sequence with a correlation value of −0.13 and a 27% time increase; the plan essentially became out of phase. Excluding these two, the plans had correlation values of 0.99. The elliptical sequence effectively simulated a respiratory pattern with a period of 6s. The period could be controlled by changing the speeds or the dose rate. Conclusion: The work first shows the quantification of the mechanical limits of the couch and the speeds at which the proposed plans begin to deviate. These limits must be kept in mind when programming other couch sequences. The methodology can be used to quantify the limits of other axes. Furthermore, the work shows the possibility of creating 4D respiratory simulations without using specialized phantoms or motion-platforms. This can be further developed to program patient-specific breathing patterns.

  8. Monte Carlo modeling of HD120 multileaf collimator on Varian TrueBeam linear accelerator for verification of 6X and 6X FFF VMAT SABR treatment plans.

    PubMed

    Bergman, Alanah M; Gete, Ermias; Duzenli, Cheryl; Teke, Tony

    2014-01-01

    A Monte Carlo (MC) validation of the vendor-supplied Varian TrueBeam 6 MV flattened (6X) phase-space file and the first implementation of the Siebers-Keall MC MLC model as applied to the HD120 MLC (for 6X flat and 6X flattening filter-free (6X FFF) beams) are described. The MC model is validated in the context of VMAT patient-specific quality assurance. The Monte Carlo commissioning process involves: 1) validating the calculated open-field percentage depth doses (PDDs), profiles, and output factors (OF), 2) adapting the Siebers-Keall MLC model to match the new HD120-MLC geometry and material composition, 3) determining the absolute dose conversion factor for the MC calculation, and 4) validating this entire linac/MLC in the context of dose calculation verification for clinical VMAT plans. MC PDDs for the 6X beams agree with the measured data to within 2.0% for field sizes ranging from 2 × 2 to 40 × 40 cm2. Measured and MC profiles show agreement in the 50% field width and the 80%-20% penumbra region to within 1.3 mm for all square field sizes. MC OFs for the 2 to 40 cm2 square fields agree with measurement to within 1.6%. Verification of VMAT SABR lung, liver, and vertebra plans demonstrate that measured and MC ion chamber doses agree within 0.6% for the 6X beam and within 2.0% for the 6X FFF beam. A 3D gamma factor analysis demonstrates that for the 6X beam, > 99% of voxels meet the pass criteria (3%/3 mm). For the 6X FFF beam, > 94% of voxels meet this criteria. The TrueBeam accelerator delivering 6X and 6X FFF beams with the HD120 MLC can be modeled in Monte Carlo to provide an independent 3D dose calculation for clinical VMAT plans. This quality assurance tool has been used clinically to verify over 140 6X and 16 6X FFF TrueBeam treatment plans.

  9. SU-E-J-24: An Evaluation of the Stability of Image Quality Parameters of Varian On-Board Imaging (OBI) and EPID Imaging Systems

    SciTech Connect

    Stanley, D; Papanikolaou, N; Gutierrez, A

    2014-06-01

    Purpose: Quality assurance of the image quality for image guided localization systems is crucial to ensure accurate visualization and localization of target volumes. In this study, the long term stability of selected image parameters was assessed and evaluated for CBCT mode, planar radiographic kV mode and the radiographic MV EPID mode. Methods: The CATPHAN, QckV-1 and QC-3 phantoms were used to evaluate the image quality parameters. The planar radiographic images were analyzed in PIPSpro™ with spatial resolution (f30, f40, f50) being recorded. For OBI CBCT, High quality head Full-Fan acquisition and Pelvis Half-Fan acquisition modes were evaluated for Uniformity, Noise, Spatial Resolution, HU constancy and geometric distortion. Dose and kVp for the OBI were recorded using the Unfors RaySafe Xi system with the R/F High Detector for planar kV and the CT detector for CBCT. Dose for the MV EPID was recorded using a PTW975 Semiflex Ion Chamber, PTW Unidos electrometer and SolidWater™. Results: For each metric, values were normalized to the mean and the standard deviations were recorded. For the planar radiographic spatial resolution the f30, f40, f50 were 0.015, 0.008, 0.004 and 0.006, 0.009, 0.018 for the kV and MV, respectively. The standard deviation of the dose for kV was 0.010 and 0.005 for the MV. The standard deviations for Full and half fan were averaged together and the following standard deviations for each metric were recorded: 0.075(uniformity), 0.071(noise), 0.006(AP-Geometric Distortion), 0.005(LAT-Geometric Distortion), 0.058(mean slice thickness), 0.098(f30),0.101(f40),0.124(f50), 0.031(Lung/PMP-HU constancy), 0.063(Water/poly-HU constancy), 0.015(Bone/Derlin-HU constancy),0.006(Dose-Center), 0.004(Dose-Periphery). Using these, tolerances can be reported as a warning and action threshold of 1σ and 2σ. Conclusion: A study was performed to assess the stability of the basic image quality parameters recommended by TG-142 for the Varian OBI and EPID

  10. An Associative Memory Model for Integration of Fragmented Research Data and Identification of Treatment Correlations in Breast Cancer Care.

    PubMed

    Banerjee, Ashis Gopal; Khan, Mridul; Higgins, John; Giani, Annarita; Das, Amar K

    2015-01-01

    A major challenge in advancing scientific discoveries using data-driven clinical research is the fragmentation of relevant data among multiple information systems. This fragmentation requires significant data-engineering work before correlations can be found among data attributes in multiple systems. In this paper, we focus on integrating information on breast cancer care, and present a novel computational approach to identify correlations between administered drugs captured in an electronic medical records and biological factors obtained from a tumor registry through rapid data aggregation and analysis. We use an associative memory (AM) model to encode all existing associations among the data attributes from both systems in a high-dimensional vector space. The AM model stores highly associated data items in neighboring memory locations to enable efficient querying operations. The results of applying AM to a set of integrated data on tumor markers and drug administrations discovered anomalies between clinical recommendations and derived associations.

  11. Ethical issues associated with the use of animal experimentation in behavioral neuroscience research.

    PubMed

    Ohl, Frauke; Meijboom, Franck

    2015-01-01

    This chapter briefly explores whether there are distinct characteristics in the field of Behavioral Neuroscience that demand specific ethical reflection. We argue that although the ethical issues in animal-based Behavioral Neuroscience are not necessarily distinct from those in other research disciplines using animal experimentation, this field of endeavor makes a number of specific, ethically relevant, questions more explicit and, as a result, may expose to discussion a series of ethical issues that have relevance beyond this field of science. We suggest that innovative research, by its very definition, demands out-of-the-box thinking. At the same time, standardization of animal models and test procedures for the sake of comparability across experiments inhibits the potential and willingness to leave well-established tracks of thinking, and leaves us wondering how open minded research is and whether it is the researcher's established perspective that drives the research rather than the research that drives the researcher's perspective. The chapter finishes by introducing subsequent chapters of this book volume on Ethical Issues in Behavioral Neuroscience.

  12. Future research needs associated with the assessment of potential human health risks from exposure to toxic ambient air pollutants.

    PubMed Central

    Möller, L; Schuetzle, D; Autrup, H

    1994-01-01

    This paper presents key conclusions and future research needs from a Workshop on the Risk Assessment of Urban Air, Emissions, Exposure, Risk Identification, and Quantification, which was held in Stockholm during June 1992 by 41 participants from 13 countries. Research is recommended in the areas of identification and quantification of toxics in source emissions and ambient air, atmospheric transport and chemistry, exposure level assessment, the development of improved in vitro bioassays, biomarker development, the development of more accurate epidemiological methodologies, and risk quantification techniques. Studies are described that will be necessary to assess and reduce the level of uncertainties associated with each step of the risk assessment process. International collaborative research efforts between industry and government organizations are recommended as the most effective way to carry out this research. PMID:7529703

  13. Behavioral Outcomes of Supervisory Education in the Association for Clinical Pastoral Education: A Qualitative Research Study.

    PubMed

    Ragsdale, Judith R; Orme-Rogers, Charles; Bush, Johnny C; Stowman, Sheryl Lyndes; Seeger, Rodney W

    2016-03-01

    This study advances the work of developing a theory for educating Clinical Pastoral Education (CPE) Supervisors by describing the behaviors which result from the successful completion of CPE supervisory education. Twenty-eight Association for Clinical Pastoral Education (ACPE) Certification Commissioners were interviewed to identify the behaviors demonstrated by Supervisory Education Students (Candidates) which influenced the decision to certify them at the level of Associate Supervisor. Specific behavioral descriptors are listed for each ACPE supervisory competency. PMID:26956745

  14. Behavioral Outcomes of Supervisory Education in the Association for Clinical Pastoral Education: A Qualitative Research Study.

    PubMed

    Ragsdale, Judith R; Orme-Rogers, Charles; Bush, Johnny C; Stowman, Sheryl Lyndes; Seeger, Rodney W

    2016-03-01

    This study advances the work of developing a theory for educating Clinical Pastoral Education (CPE) Supervisors by describing the behaviors which result from the successful completion of CPE supervisory education. Twenty-eight Association for Clinical Pastoral Education (ACPE) Certification Commissioners were interviewed to identify the behaviors demonstrated by Supervisory Education Students (Candidates) which influenced the decision to certify them at the level of Associate Supervisor. Specific behavioral descriptors are listed for each ACPE supervisory competency.

  15. Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan.

    PubMed

    Koga, Hiroshi; Iida, Koichi; Maeda, Tomoki; Takahashi, Mizuho; Fukushima, Naoki; Goshi, Terufumi

    2016-01-01

    To investigate malformations associated with cleft lip and cleft palate, we conducted surveys at neonatal intensive care units (NICUs) and other non-NICU facilities and to determine whether there are differences among facilities. The regional survey investigated NICU facilities located in Oita Prefecture, including 92 patients with cleft lip and palate (CLP) or cleft palate (CP) that occurred between 2004 and 2013, and the national survey investigated oral surgery, plastic surgery, and obstetrics and gynecology facilities located in Japan, including 16,452 patients with cleft lip (CL), CLP, or CP that occurred since 2000. The incidence per 10,000 births was 4.2, 6.2, and 2.8 for CL, CLP, and CP, respectively, according to the national survey, and 6.3 and 2.9 for CLP and CP, respectively according to the regional survey. These results indicated comparable incidences between the two surveys. In contrast, when the survey results on malformations associated with CLP and CP according to the ICD-10 classification were compared between the national survey conducted at oral surgery or plastic surgery facilities and the regional survey conducted at NICU facilities, the occurrence of associated malformations was 19.8% vs. 41.3% for any types of associated malformation, 6.8% vs. 21.7% for congenital heart disease, and 0.5% vs. 16.3% for chromosomal abnormalities. These results indicated that the incidences of all of these associated malformations were significantly greater in the survey conducted at NICU facilities and similar to the findings from international epidemiological surveys. When comparing the survey conducted at obstetrics facilities vs. NICU facilities, the occurrence of associated malformations was similar results as above. The incidence of CLP and CP was not different between surveys conducted at NICU facilities vs. non-NICU facilities; however, when conducting surveys on associated malformations, it is possible to obtain accurate epidemiological data by

  16. Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan

    PubMed Central

    Koga, Hiroshi; Iida, Koichi; Maeda, Tomoki; Takahashi, Mizuho; Fukushima, Naoki; Goshi, Terufumi

    2016-01-01

    To investigate malformations associated with cleft lip and cleft palate, we conducted surveys at neonatal intensive care units (NICUs) and other non-NICU facilities and to determine whether there are differences among facilities. The regional survey investigated NICU facilities located in Oita Prefecture, including 92 patients with cleft lip and palate (CLP) or cleft palate (CP) that occurred between 2004 and 2013, and the national survey investigated oral surgery, plastic surgery, and obstetrics and gynecology facilities located in Japan, including 16,452 patients with cleft lip (CL), CLP, or CP that occurred since 2000. The incidence per 10,000 births was 4.2, 6.2, and 2.8 for CL, CLP, and CP, respectively, according to the national survey, and 6.3 and 2.9 for CLP and CP, respectively according to the regional survey. These results indicated comparable incidences between the two surveys. In contrast, when the survey results on malformations associated with CLP and CP according to the ICD-10 classification were compared between the national survey conducted at oral surgery or plastic surgery facilities and the regional survey conducted at NICU facilities, the occurrence of associated malformations was 19.8% vs. 41.3% for any types of associated malformation, 6.8% vs. 21.7% for congenital heart disease, and 0.5% vs. 16.3% for chromosomal abnormalities. These results indicated that the incidences of all of these associated malformations were significantly greater in the survey conducted at NICU facilities and similar to the findings from international epidemiological surveys. When comparing the survey conducted at obstetrics facilities vs. NICU facilities, the occurrence of associated malformations was similar results as above. The incidence of CLP and CP was not different between surveys conducted at NICU facilities vs. non-NICU facilities; however, when conducting surveys on associated malformations, it is possible to obtain accurate epidemiological data by

  17. [Pharmacogenetic research in the association between human leukocyte antigen and adverse drug reactions].

    PubMed

    Xiong, Yan; Zhang, Wei; Chen, Xiaoping

    2014-07-01

    With the rapid development of pharmacogenetics, more and more studies have shown evidence in the association between polymorphisms at the human leukocyte antigen (HLA) loci and severe adverse drug reactions (SADRs). Several HLA-B alleles proved to be associated with SADRs for drugs such as carbamazepine, allopurinol, lamotrigine, and flucloxacillin. The USA Food and Drug Administration (FDA) has even recommended routine screening for HLA-B allele before the use of abacavir and carbamazepine. With the completion of human genome project and the Hapmap project, several new pharmacogenetics approaches such as genome-wide association study (GWAS) have emerged. These newly developed methods will undoubtedly accelerate the identification and clinical utilization of the pharmacogenetic biomakers. In addition, the immunogenetic mechanisms by which the HLA alleles cause SADRs are explored at the cellular and molecular level. This review focuses on the recent progresses in HLA alleles and ADRs regarding both the clinical translation and modern pharmacogenetic methods. PMID:25080918

  18. The dysregulated cluster in personality profiling research: Longitudinal stability and associations with bulimic behaviors and correlates

    PubMed Central

    Slane, Jennifer D.; Klump, Kelly L.; Donnellan, M. Brent; McGue, Matthew; Iacono, William G.

    2013-01-01

    Among cluster analytic studies of the personality profiles associated with bulimia nervosa, a group of individuals characterized by emotional lability and behavioral dysregulation (i.e., a dysregulated cluster) has emerged most consistently. However, previous studies have all been cross-sectional and mostly used clinical samples. This study aimed to replicate associations between the dysregulated personality cluster and bulimic symptoms and related characteristics using a longitudinal, population-based sample. Participants were females assessed at ages 17 and 25 from the Minnesota Twin Family Study, clustered based on their personality traits. The Dysregulated cluster was successfully identified at both time points and was more stable across time than either the Resilient or Sensation Seeking clusters. Rates of bulimic symptoms and related behaviors (e.g., alcohol use problems) were also highest in the dysregulated group. Findings suggest that the dysregulated cluster is a relatively stable and robust profile that is associated with bulimic symptoms. PMID:23398096

  19. [Management of biofilm-associated infections: what can we expect from recent research on biofilm lifestyles?].

    PubMed

    Lebeaux, David; Ghigo, Jean-Marc

    2012-01-01

    Biofilms are surface-associated microbial communities present in all environments. Although biofilms play important ecological roles, they also lead to negative or deleterious effects in industrial and medical settings. In the latter, high levels of antibiotic tolerance of bacterial biofilms developing on medical devices and during chronic infections determine the physiopathology of many healthcare-associated infections. Original approaches have been developed to avoid bacterial adhesion or biofilm development targetting specific mechanisms or pathways. We herein review recent data about biofilm lifestyle understanding and ways to fight against related infections.

  20. Helmet-mounted display and associated research activities recently conducted by the NASA Johnson Space Center

    NASA Astrophysics Data System (ADS)

    Marmolejo, Jose A.

    1994-06-01

    To enhance manned extravehicular activity (EVA) utilizing an extravehicular mobility unit (EMU)(i.e., a space suit and portable life support backpack), NASA has conducted research into implementing helmet mounted display (HMD) and related technology within its next generation of space suits. The NASA/Johnson Space Center has completed four feasibility development programs for the design and development of an EMU HMD, each resulting in the delivery of a binocular or biocular HMD breadboard unit utilizing conventional optical elements (i.e., glass lenses and beamsplitters) and/or holographic optics. Additional research into combining the use of voice recognition for astronaut 'hands- free' access to information via the HMD has also been conducted. Research conducted since 1983 will be summarized along with current shuttle EMU display enhancements. In addition, recommendations for the design of the next generation of displays for use within the EMU will be presented.

  1. A Scientometric Study of Research Papers Published by Visiting Associates of IUCAA, Pune, India during 2003-2013

    NASA Astrophysics Data System (ADS)

    Rai, V. K.; Senger, K. P. S.; Pathak, S. K.

    2015-04-01

    The Inter-University Centre for Astronomy and Astrophysics (IUCAA) is set up by the University Grants Commission (UGC) to promote the development and growth of active groups in astronomy and astrophysics at Indian universities. To highlight the IUCAA Associates program and associates' output during their tenure in the program, we decided to study the academic scientific output of IUCAA associates from 2003 to 2013. This paper is an Informetric analysis of 1009 papers published by IUCAA associates from 2003 to 2013, compiled and downloaded from the institute's website, annual reports, and the ADS. There is no doubt that collaboration is a common phenomenon in research. This paper examines the collaborative strength and patterns of authorship among IUCAA associates, covering a period of 10 years. The results of the data were analyzed based on the number of articles published per year, patterns of authorship, and the degree and strength of collaboration of authors. Further, the study investigated highly prolific authors and highly preferred journals by the IUCAA associates during the study period.

  2. An Examination of the Navy's Associate Degree Completion Program; A Research Report Submitted to the Faculty.

    ERIC Educational Resources Information Center

    Thornsley, John T.

    The present Associate Degree Completion Program (ADCOP), which enrolls approximately 2,700 senior enlisted personnel in 14 junior colleges for full-time vocational/technical study at Navy expense, is costly and of little tangible benefit to the Navy. The ADCOP was designed in 1966 as a method of retraining career enlisted personnel and encouraging…

  3. The Associate Degree Nursing Program at Rio Hondo College: A Research Report.

    ERIC Educational Resources Information Center

    Michaels, Joseph

    During 1975-76, an evaluation of the Associate Degree Nursing (ADN) program at Rio Hondo College was undertaken which involved: (1) surveying all nursing graduates in the classes of 1973, 1974, and 1975, and all fourth semester students currently enrolled in the program; (2) surveying or interviewing all instructional staff for the ADN program;…

  4. Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps

    PubMed Central

    Bailey, Kathryn A.; Smith, Allan H.; Tokar, Erik J.; Graziano, Joseph H.; Kim, Kyoung-Woong; Navasumrit, Panida; Ruchirawat, Mathuros; Thiantanawat, Apinya; Suk, William A.; Fry, Rebecca C.

    2015-01-01

    Background Millions of individuals worldwide, particularly those living in rural and developing areas, are exposed to harmful levels of inorganic arsenic (iAs) in their drinking water. Inorganic As exposure during key developmental periods is associated with a variety of adverse health effects, including those that are evident in adulthood. There is considerable interest in identifying the molecular mechanisms that relate early-life iAs exposure to the development of these latent diseases, particularly in relationship to cancer. Objectives This work summarizes research on the molecular mechanisms that underlie the increased risk of cancer development in adulthood that is associated with early-life iAs exposure. Discussion Epigenetic reprogramming that imparts functional changes in gene expression, the development of cancer stem cells, and immunomodulation are plausible underlying mechanisms by which early-life iAs exposure elicits latent carcinogenic effects. Conclusions Evidence is mounting that relates early-life iAs exposure and cancer development later in life. Future research should include animal studies that address mechanistic hypotheses and studies of human populations that integrate early-life exposure, molecular alterations, and latent disease outcomes. Citation Bailey KA, Smith AH, Tokar EJ, Graziano JH, Kim KW, Navasumrit P, Ruchirawat M, Thiantanawat A, Suk WA, Fry RC. 2016. Mechanisms underlying latent disease risk associated with early-life arsenic exposure: current research trends and scientific gaps. Environ Health Perspect 124:170–175; http://dx.doi.org/10.1289/ehp.1409360 PMID:26115410

  5. A Report on the Activities, Publications, and Pending Research of DHS/DOD Sponsored Post-doctoral Research Associate at Los Alamos National Laboratory

    SciTech Connect

    Stanley, Floyd E.; Tandon, Lav

    2012-04-26

    Since beginning at Los Alamos National Laboratory in February of 2012, I have been working as a DHS./DNDO Postdoctoral Research Associate under the mentorship of Lav Tandon and Khalil Spencer (NA-22 and mass spectrometry). The focus of my efforts, in addition to pursuing needed training and qualifications, has been the application of various instrumental approaches (e.g. Thermal Ionization Mass Spectrometry; TIMS) to a range of systems of interest in materials characterization and nuclear forensics. Research to be pursued in the coming months shall include the continued use of such approaches to advance current methods for: modified total evaporation, monitoring critical minor isotope systems, and chronometry. Each of the above points will be discussed.

  6. Association for Research in Vision and Ophthalmology (ARVO)--2010 Annual Meeting. For Sight: The Future of Eye and Vision Research--part 2.

    PubMed

    Hookes, Livia

    2010-07-01

    The 2010 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), held in Fort Lauderdale, FL, USA, included topics covering new therapeutic developments in the field of eye and vision research. This conference report highlights selected presentations on the development of OT-440 (Othera Pharmaceuticals Inc) for the potential treatment of glaucoma, an extended-release implant of brimonidine (pSivida Corp) for ocular hypertension, AR-12286 (Aerie Pharmaceuticals Inc) for ocular hypertension or glaucoma, AC-8 (Calmune Corp/RiboVax Biotechnologies SA) for ocular diseases following HSV infection, and fidarestat (Sanwa Kagaku Kenkyusho Co Ltd) and the recombinant proteins NOV and NOVCter (INSERM/University Rene Descartes) for corneal neovascularization.

  7. Research and Teaching: Association of Summer Bridge Program Outcomes with STEM Retention of Targeted Demographic Groups

    ERIC Educational Resources Information Center

    Tomasko, David L.; Ridgway, Judith S.; Waller, Rocquel J.; Olesik, Susan V.

    2016-01-01

    Retention of students to science, technology, engineering, and mathematics (STEM) major has been studied for four cohorts participating in a summer bridge program supported by the National Science Foundation. Students participated in a 6-week program prior to their first term of enrollment at a research-intensive land grant university. Comparisons…

  8. Maryland 2000. Journal of the Maryland Association for Institutional Research, 1993.

    ERIC Educational Resources Information Center

    Clagett, Craig A., Ed.; Huntington, Robin B., Ed.

    1993-01-01

    This volume offers nine papers on higher education research in Maryland all of which were presented at annual meetings from 1990 through 1993. The following papers are included: (1) "The Geo-Demographic Approach to Student Recruitment: The PG-TRAK90" Lifestyle Cluster System" (Karl Boughan); (2) "Evaluating College Services: A QUEST for…

  9. 78 FR 55728 - Society of Clinical Research Associates-Food and Drug Administration: Food and Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... Administration: Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good... workshop regarding FDA's clinical trial requirements is designed to aid the clinical research professional... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical...

  10. Recycling rubber wastes. (Latest citations from the rubber and plastics research association database). Published Search

    SciTech Connect

    Not Available

    1994-05-01

    The bibliography contains citations concerning research and innovations in the recycling of rubber wastes. Recycling methods and equipment, applications of recycled rubber, and energy recovery systems and performance are among the topics discussed. Recycling methods compared and contrasted with various rubber waste disposal techniques are also included. (Contains a minimum of 89 citations and includes a subject term index and title list.)

  11. Recycling rubber wastes. (Latest citations from the Rubber and Plastics Research Association database). Published Search

    SciTech Connect

    1995-02-01

    The bibliography contains citations concerning research and innovations in the recycling of rubber wastes. Recycling methods and equipment, applications of recycled rubber, and energy recovery systems and performance are among the topics discussed. Recycling methods compared and contrasted with various rubber waste disposal techniques are also included. (Contains a minimum of 96 citations and includes a subject term index and title list.)

  12. The Information Search Process: A Study of Elements Associated with Meaningful Research Tasks.

    ERIC Educational Resources Information Center

    Garland, Kathleen

    1995-01-01

    Describes a study at a Michigan high school that investigated elements that contributed to a meaningful library research task. Highlights include information literacy; students' feelings of satisfaction and achievement; student questionnaires and student and teacher interviews; group work; and process instruction. (LRW)

  13. The Information Search Process: A Study of Elements Associated with Meaningful Research Tasks.

    ERIC Educational Resources Information Center

    Garland, Kathleen

    1995-01-01

    Describes a study that investigated research projects at a secondary professional development school to determine successful task factors. Results show that student choice of topic, group work, topics related to course content, clear communication by teachers of goals and evaluation methods, and process instruction were related to student…

  14. Treatment Integrity in Psychotherapy Research: Analysis of the Studies and Examination of the Associated Factors

    ERIC Educational Resources Information Center

    Perepletchikova, Francheska; Treat, Teresa A.; Kazdin, Alan E.

    2007-01-01

    Treatment integrity refers to the degree to which an intervention is delivered as intended. Two studies evaluated the adequacy of treatment integrity procedures (including establishing, assessing, evaluating, and reporting integrity; therapist treatment adherence; and therapist competence) implemented in psychotherapy research, as well as…

  15. Education, Science, and the Politics of Knowledge: The American Educational Research Association, 1915-1940

    ERIC Educational Resources Information Center

    Mershon, Sherie; Schlossman, Steven

    2008-01-01

    In the early twentieth century, a new alliance formed between university-based scholars who dedicated themselves to the scientific study of education and public school officials. This alliance centered on the proposition that applied research could advance the professionalization of schooling and become a prestigious academic specialty in its own…

  16. American Vocational Education Research Association Proceedings (Cincinnati, Ohio, December 5-8, 1996).

    ERIC Educational Resources Information Center

    Redmann, Donna H., Ed.

    The following papers are included: "Research and Teaching from the Web/Multimedia" (Swan); "Vocational Teachers' Attitude toward, Knowledge of, and Use of National Skill Standards" (Belcher, McCaslin); "Predicting the Leadership Effectiveness of Vocational Education Administrators" (Daughtry, Finch); "Coping Behaviors and Transitions of Managerial…

  17. A Quantitative Assessment of the Research Chefs Association Core Competencies for the Practicing Culinologist

    ERIC Educational Resources Information Center

    Bissett, Rachel L.; Cheng, Michael S. H.; Brannan, Robert G.

    2010-01-01

    Professional organizations have linked core competency to professional success and competitive strategy. The Research Chefs Assn. (RCA) recently released 43 core competencies for practicing culinologists. Culinology[R] is a profession that links skills of culinary arts and food science and technology in the development of food products. An online…

  18. Water Footprint Assessment and the Panta Rhei research initiative of the International Association of Hydrological Sciences (IAHS).

    NASA Astrophysics Data System (ADS)

    Savenije, H.

    2014-12-01

    "Panta Rhei - Everything Flows" is the new scientific decade, 2013-2022, of the International Association of Hydrological Sciences (IAHS). It is dedicated to understanding issues linked with the interactions between hydrology and society in the context of change. The purpose of Panta Rhei is to reach an improved interpretation of the processes governing the water cycle in the Anthropocene, an improved prediction of such systems, and where possible to provide input for policy and practice, aimed at water security, human wellbeing and development. This talk discusses the research initiative, explores the possibility of research innovations offered by the research initiative and how water footprint assessment is a valuable tool to understand and assess human impacts on the water cycle in the Anthropocene.

  19. Melanoma Associated with TNFα Inhibitors: a Research on Adverse Drug events And Reports (RADAR) Project

    PubMed Central

    Nardone, B.; Hammel, J.A.; Raisch, D.W.; Weaver, L.L.; Schneider, D.; West, D.P.

    2014-01-01

    Background Tumor necrosis factor-alpha inhibitors (TNFαIs) are used for treatment of inflammatory disorders. There is evidence linking these agents with occurrence of malignancies. For four out of five TNFαIs the Food and Drug Administration (FDA) label states, “melanoma has been reported in patients treated with these agents.” Objectives Determine whether a statistically-significant association exists between administration of TNFαIs and development of malignant melanoma. Methods We searched the FDA Adverse Events Reporting System (FAERS) database for terms related to melanoma and TNFαIs for detection of safety signals. We also searched a large urban academic electronic medical record (EMR) database for which we calculated the relative risk (RR) of melanoma in subjects exposed to TNFαIs vs. non-exposed subjects. Results There were 972 reports of melanoma associated with a TNFαIs identified in the FAERS database, with 69 reports among individuals using more than one TNFαI. A safety signal was detected for infliximab (I) golimumab (G), etanercept (E), and adalimumab (A). Cetrolizumab pegol (CP) had no detectible safety signal. For TNFαIs as a class of drugs, a safety signal was detectable in the FAERS database, and RR was significant in the EMR database. For the EMR cohort, 6,045 patients were exposed to TNFαIs and 35 cases of melanoma were detected. Significance for RR was detected for A (RR = 1.8, p = 0.02) and E (RR 2.35, p = 0.0004). Conclusions We identified a significant association between exposure to TNFαIs and malignant melanoma in two different analyses. Our findings add to existing evidence linking these agents with the occurrence of malignant melanoma. Additional investigations are required to further explore this association and the risk of melanoma with TNFαI therapy. PMID:24328939

  20. Controversies and challenges in research on urogenital schistosomiasis-associated bladder cancer

    PubMed Central

    Honeycutt, Jared; Hammam, Olfat; Fu, Chi-Ling; Hsieh, Michael H.

    2014-01-01

    Urogenital schistosomiasis, infection with Schistosoma haematobium, is linked to increased risk for the development of bladder cancer, but the importance of various mechanisms responsible for this association remains unclear, in part due to lack of sufficient and appropriate animal models. New advances in the study of this parasite, bladder regenerative processes, and human schistosomal bladder cancers may shed new light on the complex biological processes that connect S. haematobium infection to bladder carcinogenesis. PMID:24913983

  1. Big data challenges in bone research: genome-wide association studies and next-generation sequencing

    PubMed Central

    Alonso, Nerea; Lucas, Gavin; Hysi, Pirro

    2015-01-01

    Genome-wide association studies (GWAS) have been developed as a practical method to identify genetic loci associated with disease by scanning multiple markers across the genome. Significant advances in the genetics of complex diseases have been made owing to advances in genotyping technologies, the progress of projects such as HapMap and 1000G and the emergence of genetics as a collaborative discipline. Because of its great potential to be used in parallel by multiple collaborators, it is important to adhere to strict protocols assuring data quality and analyses. Quality control analyses must be applied to each sample and each single-nucleotide polymorphism (SNP). The software package PLINK is capable of performing the whole range of necessary quality control tests. Genotype imputation has also been developed to substantially increase the power of GWAS methodology. Imputation permits the investigation of associations at genetic markers that are not directly genotyped. Results of individual GWAS reports can be combined through meta-analysis. Finally, next-generation sequencing (NGS) has gained popularity in recent years through its capacity to analyse a much greater number of markers across the genome. Although NGS platforms are capable of examining a higher number of SNPs compared with GWA studies, the results obtained by NGS require careful interpretation, as their biological correlation is incompletely understood. In this article, we will discuss the basic features of such protocols. PMID:25709812

  2. Evaluation of Strategies to Separate Root-Associated Microbial Communities: A Crucial Choice in Rhizobiome Research

    PubMed Central

    Richter-Heitmann, Tim; Eickhorst, Thilo; Knauth, Stefan; Friedrich, Michael W.; Schmidt, Hannes

    2016-01-01

    Plants shape distinct, species-specific microbiomes in their rhizospheres. A main premise for evaluating microbial communities associated with root-soil compartments is their successful separation into the rhizosphere (soil-root interface), the rhizoplane (root surface), and the endosphere (inside roots). We evaluated different approaches (washing, sonication, and bleaching) regarding their efficiency to separate microbial cells associated with different root compartments of soil-grown rice using fluorescence microscopy and community fingerprinting of 16S rRNA genes. Vigorous washing detached 45% of the rhizoplane population compared to untreated roots. Additional sonication reduced rhizoplane-attached microorganisms by up to 78% but caused various degrees of root tissue destruction at all sonication intensities tested. Treatment with sodium hypochlorite almost completely (98%) removed rhizoplane-associated microbial cells. Community fingerprinting revealed that microbial communities obtained from untreated, washed, and sonicated roots were not statistically distinguishable. Hypochlorite-treated roots harbored communities significantly different from all other samples, likely representing true endospheric populations. Applying these procedures to other root samples (bean and clover) revealed that treatment efficiencies were strongly affected by root morphological parameters such as root hair density and rigidity of epidermis. Our findings suggest that a careful evaluation of separation strategies prior to molecular community analysis is indispensable, especially when endophytes are the subject of interest. PMID:27252690

  3. Evaluation of Strategies to Separate Root-Associated Microbial Communities: A Crucial Choice in Rhizobiome Research.

    PubMed

    Richter-Heitmann, Tim; Eickhorst, Thilo; Knauth, Stefan; Friedrich, Michael W; Schmidt, Hannes

    2016-01-01

    Plants shape distinct, species-specific microbiomes in their rhizospheres. A main premise for evaluating microbial communities associated with root-soil compartments is their successful separation into the rhizosphere (soil-root interface), the rhizoplane (root surface), and the endosphere (inside roots). We evaluated different approaches (washing, sonication, and bleaching) regarding their efficiency to separate microbial cells associated with different root compartments of soil-grown rice using fluorescence microscopy and community fingerprinting of 16S rRNA genes. Vigorous washing detached 45% of the rhizoplane population compared to untreated roots. Additional sonication reduced rhizoplane-attached microorganisms by up to 78% but caused various degrees of root tissue destruction at all sonication intensities tested. Treatment with sodium hypochlorite almost completely (98%) removed rhizoplane-associated microbial cells. Community fingerprinting revealed that microbial communities obtained from untreated, washed, and sonicated roots were not statistically distinguishable. Hypochlorite-treated roots harbored communities significantly different from all other samples, likely representing true endospheric populations. Applying these procedures to other root samples (bean and clover) revealed that treatment efficiencies were strongly affected by root morphological parameters such as root hair density and rigidity of epidermis. Our findings suggest that a careful evaluation of separation strategies prior to molecular community analysis is indispensable, especially when endophytes are the subject of interest. PMID:27252690

  4. Evaluation of medical research performance – position paper of the Association of the Scientific Medical Societies in Germany (AWMF)

    PubMed Central

    Herrmann-Lingen, Christoph; Brunner, Edgar; Hildenbrand, Sibylle; Loew, Thomas H.; Raupach, Tobias; Spies, Claudia; Treede, Rolf-Detlef; Vahl, Christian-Friedrich; Wenz, Hans-Jürgen

    2014-01-01

    Objective: The evaluation of medical research performance is a key prerequisite for the systematic advancement of medical faculties, research foci, academic departments, and individual scientists’ careers. However, it is often based on vaguely defined aims and questionable methods and can thereby lead to unwanted regulatory effects. The current paper aims at defining the position of German academic medicine toward the aims, methods, and consequences of its evaluation. Methods: During the Berlin Forum of the Association of the Scientific Medical Societies in Germany (AWMF) held on 18 October 2013, international experts presented data on methods for evaluating medical research performance. Subsequent discussions among representatives of relevant scientific organizations and within three ad-hoc writing groups led to a first draft of this article. Further discussions within the AWMF Committee for Evaluation of Performance in Research and Teaching and the AWMF Executive Board resulted in the final consented version presented here. Results: The AWMF recommends modifications to the current system of evaluating medical research performance. Evaluations should follow clearly defined and communicated aims and consist of both summative and formative components. Informed peer reviews are valuable but feasible in longer time intervals only. They can be complemented by objective indicators. However, the Journal Impact Factor is not an appropriate measure for evaluating individual publications or their authors. The scientific “impact” rather requires multidimensional evaluation. Indicators of potential relevance in this context may include, e.g., normalized citation rates of scientific publications, other forms of reception by the scientific community and the public, and activities in scientific organizations, research synthesis and science communication. In addition, differentiated recommendations are made for evaluating the acquisition of third-party funds and the

  5. Recycling rubber wastes. (Latest citations from the Rubber and Plastics Research Association database). Published Search

    SciTech Connect

    1996-04-01

    The bibliography contains citations concerning research and innovations in the recycling of rubber wastes. Recycling methods and equipment, applications of recycled rubber, and energy recovery systems and performance are among the topics discussed. Recycling methods compared and contrasted with various rubber waste disposal techniques are also included. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  6. SU-E-J-47: Comparison of Online Image Registrations of Varian TrueBeam Cone-Beam CT and BrainLab ExacTrac Imaging Systems

    SciTech Connect

    Li, J; Shi, W; Andrews, D; Werner-Wasik, M; Yu, Y; Liu, H

    2015-06-15

    Purpose To compare online image registrations of TrueBeam cone-beam CT (CBCT) and BrainLab ExacTrac imaging systems. Methods Tests were performed on a Varian TrueBeam STx linear accelerator (Version 2.0), which is integrated with a BrainLab ExacTrac imaging system (Version 6.0.5). The study was focused on comparing the online image registrations for translational shifts. A Rando head phantom was placed on treatment couch and immobilized with a BrainLab mask. The phantom was shifted by moving the couch translationally for 8 mm with a step size of 1 mm, in vertical, longitudinal, and lateral directions, respectively. At each location, the phantom was imaged with CBCT and ExacTrac x-ray. CBCT images were registered with TrueBeam and ExacTrac online registration algorithms, respectively. And ExacTrac x-ray image registrations were performed. Shifts calculated from different registrations were compared with nominal couch shifts. Results The averages and ranges of absolute differences between couch shifts and calculated phantom shifts obtained from ExacTrac x-ray registration, ExacTrac CBCT registration with default window, ExaxTrac CBCT registration with adjusted window (bone), Truebeam CBCT registration with bone window, and Truebeam CBCT registration with soft tissue window, were: 0.07 (0.02–0.14), 0.14 (0.01–0.35), 0.12 (0.02–0.28), 0.09 (0–0.20), and 0.06 (0–0.10) mm, in vertical direction; 0.06 (0.01–0.12), 0.27 (0.07–0.57), 0.23 (0.02–0.48), 0.04 (0–0.10), and 0.08 (0– 0.20) mm, in longitudinal direction; 0.05 (0.01–0.21), 0.35 (0.14–0.80), 0.25 (0.01–0.56), 0.19 (0–0.40), and 0.20 (0–0.40) mm, in lateral direction. Conclusion The shifts calculated from ExacTrac x-ray and TrueBeam CBCT registrations were close to each other (the differences between were less than 0.40 mm in any direction), and had better agreements with couch shifts than those from ExacTrac CBCT registrations. There were no significant differences between True

  7. Ten Years A-Talking! Reflecting on the Role of the EERA Council from the Perspective of National Educational Research Associations

    ERIC Educational Resources Information Center

    O'Hara, Joe; Holm, Gunilla

    2014-01-01

    Drawing on their personal experiences, the authors reflect on the relationship between the European Educational Research Association (EERA) Council and the National Educational Research Associations (NERAs). The article will argue that while much of the work undertaken by the EERA Council is hugely valuable, at times it can be difficult to see a…

  8. Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research.

    PubMed

    Lee, Sung Jong; Yang, Andrew; Wu, T C; Hung, Chien Fu

    2016-09-01

    Cervical cancer is the fourth most lethal women's cancer worldwide. Current treatments against cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenic agents. However, despite the various treatments utilized for the treatment of cervical cancer, its disease burden remains a global issue. Persistent infection of human papillomavirus (HPV) has been identified as an essential step of pathogenesis of cervical cancer and many other cancers, and nation-wide HPV screening as well as preventative HPV vaccination program have been introduced globally. However, even though the commercially available prophylactic HPV vaccines, Gardasil (Merck) and Cervarix (GlaxoSmithKline), are effective in blocking the entry of HPV into the epithelium of cervix through generation of HPV-specific neutralizing antibodies, they cannot eliminate the pre-existing HPV infection. For these reason, other immunotherapeutic options against HPV-associated diseases, including therapeutic vaccines, have been continuously explored. Therapeutic HPV vaccines enhance cell-mediated immunity targeting HPV E6 and E7 antigens by modulating primarily dendritic cells and cytotoxic T lymphocyte. Our review will cover various therapeutic vaccines in development for the treatment of HPV-associated lesions and cancers. Furthermore, we will discuss the potential of immune checkpoint inhibitors that have recently been adopted and tested for their treatment efficacy against HPV-induced cervical cancer.

  9. RESEARCH: Perceptions of Risk Associated with Use of Farm Chemicals: Implications for Conservation Initiatives

    PubMed

    Tucker; Napier

    1998-07-01

    / Data were collected from 245 farmers within the Darby Creek hydrologic unit in central Ohio to assess perceptions of risk associated with use of farm chemicals. Farmers were asked to evaluate the level of risk associated with use of agricultural chemicals for water quality, food safety, food quality, health of applicator, health of farm animals, wildlife, beneficial plants, beneficial insects, and human health. Study findings revealed that respondents perceived use of farm chemicals posed little or no threat to any of the assessed items. A composite index was formulated from the responses to the nine items and was titled Perceived Risk. Variance in the Perceived Risk index was regressed against social learning variables. The findings revealed that approximately 32% of the variance was explained by the predictive variables included in the model. It was concluded that the theoretical perspective was somewhat useful for understanding perceptions held about agricultural chemical use at the farm level. The findings are discussed in the context of future conservation and educational-information programs within the study region.KEY WORDS: Risk perception; Risk assessment; Groundwater; Pesticide contamination; Food safety; Environmental quality

  10. Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research

    PubMed Central

    2016-01-01

    Cervical cancer is the fourth most lethal women's cancer worldwide. Current treatments against cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenic agents. However, despite the various treatments utilized for the treatment of cervical cancer, its disease burden remains a global issue. Persistent infection of human papillomavirus (HPV) has been identified as an essential step of pathogenesis of cervical cancer and many other cancers, and nation-wide HPV screening as well as preventative HPV vaccination program have been introduced globally. However, even though the commercially available prophylactic HPV vaccines, Gardasil (Merck) and Cervarix (GlaxoSmithKline), are effective in blocking the entry of HPV into the epithelium of cervix through generation of HPV-specific neutralizing antibodies, they cannot eliminate the pre-existing HPV infection. For these reason, other immunotherapeutic options against HPV-associated diseases, including therapeutic vaccines, have been continuously explored. Therapeutic HPV vaccines enhance cell-mediated immunity targeting HPV E6 and E7 antigens by modulating primarily dendritic cells and cytotoxic T lymphocyte. Our review will cover various therapeutic vaccines in development for the treatment of HPV-associated lesions and cancers. Furthermore, we will discuss the potential of immune checkpoint inhibitors that have recently been adopted and tested for their treatment efficacy against HPV-induced cervical cancer. PMID:27329199

  11. Changes in heart rate variability associated with acute alcohol consumption: current knowledge and implications for practice and research.

    PubMed

    Romanowicz, Magdalena; Schmidt, John E; Bostwick, John M; Mrazek, David A; Karpyak, Victor M

    2011-06-01

    Alcohol consumption is associated with a broad array of physiologic and behavioral effects including changes in heart rate. However, the physiologic mechanisms of alcohol effects and the reasons for individual differences in the cardiac response remain unknown. Measuring changes in resting heart rate (measured as beats/min) has not been found to be as sensitive to alcohol's effects as changes in heart rate variability (HRV). HRV is defined as fluctuations in interbeat interval length which reflect the heart's response to extracardiac factors that affect heart rate. HRV allows simultaneous assessment of both sympathetic and parasympathetic activity and the interplay between them. Increased HRV has been associated with exercise and aerobic fitness, while decreased HRV has been associated with aging, chronic stress, and a wide variety of medical and psychiatric disorders. Decreased HRV has predictive value for mortality in general population samples and patients with myocardial infarction and used as an indicator of altered autonomic function. A significant inverse correlation was found between HRV and both the severity of depression and the duration of the depressive episode. HRV analysis provides insights into mechanisms of autonomic regulation and is extensively used to clarify relationships between depression and cardiovascular disease. This article will review the methodology of HRV measurements and contemporary knowledge about effects of acute alcohol consumption on HRV. Potential implications of this research include HRV response to alcohol that could serve as a marker for susceptibility to alcoholism. At present however there is almost no research data supporting this hypothesis. PMID:21332532

  12. A Global Perspective on Using Implementation Research to Address Hypertension-Associated Target Organ Damage.

    PubMed

    Peprah, Emmanuel; Lopez-Class, Maria; Shero, Susan; John-Sowah, Joylene; Engelgau, Michael

    2016-01-01

    Hypertension, a major risk factor for cardiovascular disease, imposes a significant public health burden and challenge to address it worldwide. Scaling up delivery of proven, effective interventions for hypertension could significantly advance the goal of reducing the global burden. Although significant progress has been made in many countries, some lament that large-scale initiatives focused on reducing blood pressure in global populations have not effectively addressed this challenge. Late-stage implementation research plays a critical role in determining effective and sustainable scale-up of these initiatives. In this article, we briefly discuss some of the global initiatives that have been funded by the National Heart, Lung, and Blood Institute of the US National Institutes of Health. Intervention delivery strategies in low resource settings must have demonstrated effectiveness and consideration for the social, cultural and physical context (eg, access, affordability, and availability of medications) in which a program is being delivered in order to be sustainable nationally and globally. Hence, the use of implementation research is central to determining sustainable delivery of evidence-based and tailored interventions focused on hypertension control. The sustained control of hypertension in global populations holds tremendous potential for reducing morbidity, premature mortality, and the adverse economic impact of cardiovascular disease in all regions. PMID:27440980

  13. Antidepressants and Breast and Ovarian Cancer Risk: A Review of the Literature and Researchers' Financial Associations with Industry

    PubMed Central

    Cosgrove, Lisa; Shi, Ling; Creasey, David E.; Anaya-McKivergan, Maria; Myers, Jessica A.; Huybrechts, Krista F.

    2011-01-01

    Background Antidepressant (AD) use has been purported to increase the risk of breast and ovarian cancer, although both epidemiological and pre-clinical studies have reported mixed results [1]–[6]. Previous studies in a variety of biomedical fields have found that financial ties to drug companies are associated with favorable study conclusions [7]. Methods and Findings We searched English-language articles in MEDLINE, PsychINFO, the Science Citations Index and the Cochrane Central Register of Controlled Clinical Trials (through November 2010). A total of 61 articles that assessed the relationship between breast and ovarian cancer and AD use and articles that examined the effect of ADs on cell growth were included. Multi-modal screening techniques were used to investigate researchers' financial ties with industry. A random effects meta-analysis was used to pool the findings from the epidemiological literature. Thirty-three percent (20/61) of the studies reported a positive association between ADs and cancer. Sixty-seven percent (41/61) of the studies reported no association or antiproliferative effect. The pooled odds ratio for the association between AD use and breast/ovarian cancer in the epidemiologic studies was 1.11 (95% CI, 1.03–1.20). Researchers with industry affiliations were significantly less likely than researchers without those ties to conclude that ADs increase the risk of breast or ovarian cancer. (0/15 [0%] vs 20/46 [43.5%] (Fisher's Exact test P = 0.0012). Conclusions Both the pre-clinical and clinical data are mixed in terms of showing an association between AD use and breast and ovarian cancer. The possibility that ADs may exhibit a bi-phasic effect, whereby short-term use and/or low dose antidepressants may increase the risk of breast and ovarian cancer, warrants further investigation. Industry affiliations were significantly associated with negative conclusions regarding cancer risk. The findings have implications in light of the 2009

  14. Research Update: Synthesis, properties, and applications of ultrathin metallic nanowires and associated heterostructures

    NASA Astrophysics Data System (ADS)

    Liu, Haiqing; Li, Luyao; Scofield, Megan E.; Wong, Stanislaus S.

    2015-08-01

    The properties of one-dimensional (1D) nanostructured materials can change considerably and unexpectedly, when their diameters attain the "ultrathin" level, i.e., below 10 nm. Herein, we have summarized recent developments associated with not only the synthesis but also more importantly, the applications of ultrathin 1D nanowires. Specifically, various classes of ultrathin metallic nanowires have been shown to be excellent, high-performing structural motifs for electrocatalysts, superconducting materials, electrical devices, and nano-sized pressure sensors. Moreover, the fabrication of ultrathin-based 0D-1D, 1D-1D, and 1D-2D composite hybrid structures may represent one of the most promising designs for novel architectures in energy storage and conversion, photovoltaic devices, photoconductivity, and photoelectrocatalysis.

  15. Treatment integrity in psychotherapy research: analysis of the studies and examination of the associated factors.

    PubMed

    Perepletchikova, Francheska; Treat, Teresa A; Kazdin, Alan E

    2007-12-01

    Treatment integrity refers to the degree to which an intervention is delivered as intended. Two studies evaluated the adequacy of treatment integrity procedures (including establishing, assessing, evaluating, and reporting integrity; therapist treatment adherence; and therapist competence) implemented in psychotherapy research, as well as predictors of their implementation. Randomized controlled trials of psychosocial interventions published in 6 influential psychological and psychiatric journals were reviewed and coded for treatment integrity implementation. Results indicate that investigations that systematically addressed treatment integrity procedures are virtually absent in the literature. Treatment integrity was adequately addressed for only 3.50% of the evaluated psychosocial interventions. Journal of publication and treatment approach predicted integrity implementation. Skill-building treatments (e.g., cognitive-behavioral) as compared with non-skill-building interventions (e.g., psychodynamic, nondirective counseling) were implemented with higher attention to integrity procedures. Guidelines for implementation of treatment integrity procedures need to be reevaluated.

  16. Issues in collecting, processing and storing human tissues and associated information to support biomedical research.

    PubMed

    Grizzle, William E; Bell, Walter C; Sexton, Katherine C

    2010-01-01

    The availability of human tissues to support biomedical research is critical to advance translational research focused on identifying and characterizing approaches to individualized (personalized) medical care. Providing such tissues relies on three acceptable models - a tissue banking model, a prospective collection model and a combination of these two models. An unacceptable model is the "catch as catch can" model in which tissues are collected, processed and stored without goals or a plan or without standard operating procedures, i.e., portions of tissues are collected as available and processed and stored when time permits. In the tissue banking model, aliquots of tissues are collected according to SOPs. Usually specific sizes and types of tissues are collected and processed (e.g., 0.1 gm of breast cancer frozen in OCT). Using the banking model, tissues may be collected that may not be used and/or do not meet specific needs of investigators; however, at the time of an investigator request, tissues are readily available as is clinical information including clinical outcomes. In the model of prospective collection, tissues are collected based upon investigator requests including specific requirements of investigators. For example, the investigator may request that two 0.15 gm matching aliquots of breast cancer be minced while fresh, put in RPMI media with and without fetal calf serum, cooled to 4°C and shipped to the investigator on wet ice. Thus, the tissues collected prospectively meet investigator needs, all collected specimens are utilized and storage of specimens is minimized; however, investigators must wait until specimens are collected, and if needed, for clinical outcome. The operation of any tissue repository requires well trained and dedicated personnel. A quality assurance program is required which provides quality control information on the diagnosis of a specimen that is matched specifically to the specimen provided to an investigator instead of an

  17. Field support, data analysis and associated research for the acoustic grenade sounding program

    NASA Technical Reports Server (NTRS)

    Barnes, T. G.; Bullard, E. R.

    1976-01-01

    Temperature and horizontal winds in the 30 to 90 km altitude range of the upper atmosphere, were determined by acoustic grenade soundings conducted at Wallops Island, Virginia and Kourou, French Guiana. Field support provided at these locations included deployment of the large area microphone system, supervision, maintenance and operation of sound ranging stations; and coordination of activities. Data analysis efforts included the analysis of field data to determine upper atmospheric meteorological parameters. Profiles for upper atmospheric temperature, wind and density are provided in plots and tables for each of the acoustic grenade soundings conducted during the contract period. Research efforts were directed toward a systematic comparison of temperature data from acoustic grenade with other meteorological sensor probes in the upper atmosphere.

  18. Tumor-Associated Glycans and Their Role in Gynecological Cancers: Accelerating Translational Research by Novel High-Throughput Approaches

    PubMed Central

    Pochechueva, Tatiana; Jacob, Francis; Fedier, Andre; Heinzelmann-Schwarz, Viola

    2012-01-01

    Glycans are important partners in many biological processes, including carcinogenesis. The rapidly developing field of functional glycomics becomes one of the frontiers of biology and biomedicine. Aberrant glycosylation of proteins and lipids occurs commonly during malignant transformation and leads to the expression of specific tumor-associated glycans. The appearance of aberrant glycans on carcinoma cells is typically associated with grade, invasion, metastasis and overall poor prognosis. Cancer-associated carbohydrates are mostly located on the surface of cancer cells and are therefore potential diagnostic biomarkers. Currently, there is increasing interest in cancer-associated aberrant glycosylation, with growing numbers of characteristic cancer targets being detected every day. Breast and ovarian cancer are the most common and lethal malignancies in women, respectively, and potential glycan biomarkers hold promise for early detection and targeted therapies. However, the acceleration of research and comprehensive multi-target investigation of cancer-specific glycans could only be successfully achieved with the help of a combination of novel high-throughput glycomic approaches. PMID:24957768

  19. American Association of Orthodontists Foundation Craniofacial Growth Legacy Collection: Overview of a powerful tool for orthodontic research and teaching.

    PubMed

    Baumrind, Sheldon; Curry, Sean

    2015-08-01

    This article reports on the current status of the American Association of Orthodontists Foundation (AAOF) Craniofacial Growth Legacy Collection--an AAOF-supported multi-institutional project that uses the Internet and cloud computing to collect and share craniofacial images and data for orthodontic research and education. The project gives investigators and clinicians all over the world online access to longitudinal information on craniofacial development in untreated children with malocclusions of various types. It also is a unique source of control samples for testing the validity of consensually accepted beliefs about the effects of orthodontic treatment or of failure to treat. PMID:26232829

  20. American Association of Orthodontists Foundation Craniofacial Growth Legacy Collection: Overview of a powerful tool for orthodontic research and teaching.

    PubMed

    Baumrind, Sheldon; Curry, Sean

    2015-08-01

    This article reports on the current status of the American Association of Orthodontists Foundation (AAOF) Craniofacial Growth Legacy Collection--an AAOF-supported multi-institutional project that uses the Internet and cloud computing to collect and share craniofacial images and data for orthodontic research and education. The project gives investigators and clinicians all over the world online access to longitudinal information on craniofacial development in untreated children with malocclusions of various types. It also is a unique source of control samples for testing the validity of consensually accepted beliefs about the effects of orthodontic treatment or of failure to treat.

  1. The Universities in a Changing World--Adaptation or Guidance? Proceedings of the European Association for Institutional Research Forum (4th, Uppsala, Sweden, August 25-27, 1982).

    ERIC Educational Resources Information Center

    Belanger, Charles H., Ed.

    Changes in higher education that affect teaching and research are addressed in the proceedings of the 1982 forum of the European Association for Institutional Research. In addition to six invited papers on adaptation or guidance of universities, papers on faculty, resources and cost indicators, research facilities and equipment, and institutional…

  2. Use of a modified Delphi approach to develop research priorities for the Association of Coloproctology of Great Britain and Ireland

    PubMed Central

    Tiernan, J; Cook, A; Geh, I; George, B; Magill, L; Northover, J; Verjee, A; Wheeler, J; Fearnhead, N

    2014-01-01

    Aim The modified Delphi approach is an established method for reaching a consensus opinion among a group of experts in a particular field. We have used this technique to survey the entire membership of the Association of Coloproctology of Great Britain and Ireland (ACPGBI) to reach a consensus on prioritizing clinical research questions in colorectal disease. Method Three rounds of surveys were conducted using a web-based tool. In the first, the ACPGBI membership was invited to submit research questions. In Rounds 2 and 3 they were asked to score questions on priority. A steering group analysed the results of each round to identify those questions ranked as being of highest priority. Results Five hundred and two questions were submitted in Round 1. Following two rounds of voting and analysis, a list of 25 priority questions was produced, including 15 cancer-related and 10 noncancer-related questions. Conclusion It is anticipated that these results will: (i) set the research agenda over the next few years for the study of colorectal disease in the United Kingdom, (ii) promote development and (iii) define funding of new research and prioritize areas of unmet clinical need where the potential clinical impact is greatest. PMID:25284641

  3. Tohoku Earthquake-associated Marine Sciences: the research project for the Great East Japan Earthquake on March 11, 2011

    NASA Astrophysics Data System (ADS)

    Kitazato, Hiroshi; Kijima, Akihiro; Kogure, Kazuhiro; Hara, Motoyuki; Nagata, Toshi; Fujikura, Kasunori; Sonoda, Akira

    2015-04-01

    At 2:46 pm on March 11, 2011, a huge earthquake (M 9.0) occurred off the Pacific coast of Tohoku Region, Japan. The subsequent Tsunamis hit the coasts and seriously damaged fishing villages and towns in the area. Tohoku Region faces Northwestern Pacific where is one of the most productive oceans on the Earth. Then, what happened to the marine ecosystems in the Tohoku Region? What happened to the fishery bioresources? What is the mechanism to sustain high productivity in the Region? Is the ecosystem restoring after 4 years? What is required for the recovery of fisheries in the area? In order to answer these questions, the 10 years research project, TEAMS (Tohoku Ecosystem-Associated Marine Sciences) was launched in January 2012 funded by MEXT (Ministry of Education, Culture, Sports, Science and Technology, Japan) to conduct comprehensive research on the area. Tohoku University (TU), Atmosphere and Ocean Research Institute, the University of Tokyo (AORIUT), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), and 25 other institutions are conducting research for this project in close association with local government and fishery people. Currently, approximately 400 people (200 scientists, 160 students and others) covering physical, chemical, biological, and geological sciences including modeling take part in the project from all over Japan. MEXT also supports TEAMS by constructing R/V Shinsei Maru in 2013 for the oceanic investigations in the region. In this report, the overview of the ecosystem before and after the disaster, major findings and challenges of TEAMS will be described.

  4. Benefits and concerns associated with biotechnology-derived foods: can additional research reduce children health risks?

    PubMed

    Cantani, A

    2006-01-01

    The development of techniques devised for the genetic manipulation of foods poses new risks for children with food allergy (FA). The introduction of foreign allergenic proteins from different foods into previously tolerated foods may trigger allergic reactions, often complicating with anaphylactic shock in a subset of allergic babies. Children with FA, even if subjected to preventative diets, always challenge the risk of developing allergic manifestations after unintentional intake of a non tolerated food in restaurant settings, with relatives or schoolmates, etc, where product labelling is necessarily lacking. The introduction of potentially allergenic proteins into foods generally considered safe for allergic children can be done deliberately, by either substantially altering the food ingredients, or by genetic manipulation which change the composition or transfer allergens, or unintentionally by quality-control failures, due to contaminations in the production process, or to genetic mismanipulation. There is a controversy between multinationals often favored by governments and consumer association resistance, thus an equidistant analysis poses some unprecedented impediments. The importance of FA and the potential of transgenic plants to bring food allergens into the food supply should not be disregarded. The expression in soybeans of a Brazil nut protein resulted in a food allergen expressed in widely used infant formulas, so paving the way to an often reported multinational debacle. Genetic engineering poses innovative ethical and social concerns, as well as serious challenges to the environment, human health, animal welfare, and the future of agriculture. In this paper will be emphasized practical concepts more crucial for pediatricians.

  5. Additional research on instabilities in atmospheric flow systems associated with clear air turbulence

    NASA Technical Reports Server (NTRS)

    Stoeffler, R. C.

    1972-01-01

    Analytical and experimental fluid mechanics studies were conducted to investigate instabilities in atmospheric flow systems associated with clear air turbulence. The experimental portion of the program was conducted using an open water channel which allows investigation of flows having wide ranges of shear and density stratification. The program was primarily directed toward studies of the stability of straight, stratified shear flows with particular emphasis on the effects of velocity profile on stability; on studies of three-dimensional effects on the breakdown region in shear layers; on the the interaction of shear flows with long-wave length internal waves; and on the stability of shear flows consisting of adjacent stable layers. The results of these studies were used to evaluate methods used in analyses of CAT encounters in the atmosphere involving wave-induced shear layer instabilities of the Kelvin-Helmholta type. A computer program was developed for predicting shear-layer instability and CAT induced by mountain waves. This technique predicts specific altitudes and locations where CAT would be expected.

  6. Recent advances in globin research using genome-wide association studies and gene editing.

    PubMed

    Orkin, Stuart H

    2016-03-01

    A long-sought goal in the hemoglobin field has been an improved understanding of the mechanisms that regulate the switch from fetal (HbF) to adult (HbA) hemoglobin during development. With such knowledge, the hope is that strategies for directed reactivation of HbF in adults could be devised as an approach to therapy for the β-hemoglobinopathies thalassemia and sickle cell disease. Recent genome-wide association studies (GWAS) led to identification of three loci (BCL11A, HBS1L-MYB, and the β-globin cluster itself) in which natural genetic variation is correlated with different HbF levels in populations. Here, the central role of BCL11A in control of HbF is reviewed from the perspective of how findings may be translated to gene therapy in the not-too-distant future. This summary traces the evolution of recent studies from the initial recognition of BCL11A through GWAS to identification of critical sequences in an enhancer required for its erythroid-specific expression, thereby highlighting an Achilles heel for genome editing.

  7. Increased Perceived Stress is Associated with Blunted Hedonic Capacity: Potential Implications for Depression Research

    PubMed Central

    Pizzagalli, Diego A.; Bogdan, Ryan; Ratner, Kyle G.; Jahn, Allison L.

    2007-01-01

    Preclinical studies suggest that stress exerts depressogenic effects by impairing hedonic capacity; in humans, however, the precise mechanisms linking stress and depression are largely unknown. As an initial step towards better understanding the association between stress and anhedonia, the present study tested, in two independent samples, whether individuals reporting elevated stress exhibit decreased hedonic capacity. The Perceived Stress Scale (PSS) measured the degree to which participants appraised their daily life as unpredictable, uncontrollable, and overwhelming. Hedonic capacity was objectively assessed using a signal-detection task based on a differential reinforcement schedule. Decreased reward responsiveness (i.e., the participants' propensity to modulate behavior as a function of reward) was used as an operational measure of hedonic capacity. In both Study 1 (n = 88) and Study 2 (n = 80), participants with high PSS scores displayed blunted reward responsiveness and reported elevated anhedonic symptoms. Additionally, PSS scores predicted reduced reward responsiveness even after controlling for general distress and anxiety symptoms. These findings are consistent with preclinical data highlighting links between stress and anhedonia, and offer promising insights into potential mechanisms linking stress to depression. PMID:17854766

  8. Benefits and concerns associated with biotechnology-derived foods: can additional research reduce children health risks?

    PubMed

    Cantani, A

    2009-01-01

    The development of techniques devised for the genetic manipulation of foods poses new risks for children with food allergy (FA). The introduction of foreign allergenic proteins from different foods into previously tolerated foods may trigger allergic reactions, often complicating with anaphylactic shock in a subset of allergic babies. Children with FA, even if subjected to preventative diets, always challenge the risk of developing allergic manifestations after unintentional intake of a non tolerated food in restaurant settings, with relatives or schoolmates, etc, where product labelling is necessarily lacking. The introduction of potentially allergenic proteins into foods generally considered safe for allergic children can be done deliberately, by either substantially altering the food ingredients, or by genetic manipulation which change the composition or transfer allergens, or unintentionally by qualitycontrol failures, due to contaminations in the production process, or to genetic mismanipulation. There is a controversy between multinationals often favored by governments and consumer association resistance, thus an equidistant analysis poses some unprecedented impediments. The importance of FA and the potential of transgenic plants to bring food allergens into the food supply should not be disregarded. The expression in soybeans of a Brazil nut protein resulted in a food allergen ex-pressed in widely used infant formulas, so paving the way to an often reported multinational debacle. Genetic engineering poses innovative ethical and social concerns, as well as serious challenges to the environment, human health, animal welfare, and the future of agriculture. In this paper will be emphasized practical concepts more crucial for pediatricians.

  9. Benefits and concerns associated with biotechnology-derived foods: can additional research reduce children health risks?

    PubMed

    Cantani, A

    2006-01-01

    The development of techniques devised for the genetic manipulation of foods poses new risks for children with food allergy (FA). The introduction of foreign allergenic proteins from different foods into previously tolerated foods may trigger allergic reactions, often complicating with anaphylactic shock in a subset of allergic babies. Children with FA, even if subjected to preventative diets, always challenge the risk of developing allergic manifestations after unintentional intake of a non tolerated food in restaurant settings, with relatives or schoolmates, etc, where product labelling is necessarily lacking. The introduction of potentially allergenic proteins into foods generally considered safe for allergic children can be done deliberately, by either substantially altering the food ingredients, or by genetic manipulation which change the composition or transfer allergens, or unintentionally by quality-control failures, due to contaminations in the production process, or to genetic mismanipulation. There is a controversy between multinationals often favored by governments and consumer association resistance, thus an equidistant analysis poses some unprecedented impediments. The importance of FA and the potential of transgenic plants to bring food allergens into the food supply should not be disregarded. The expression in soybeans of a Brazil nut protein resulted in a food allergen expressed in widely used infant formulas, so paving the way to an often reported multinational debacle. Genetic engineering poses innovative ethical and social concerns, as well as serious challenges to the environment, human health, animal welfare, and the future of agriculture. In this paper will be emphasized practical concepts more crucial for pediatricians. PMID:16910351

  10. Benefits and concerns associated with biotechnology-derived foods: can additional research reduce children health risks?

    PubMed

    Cantani, A

    2009-01-01

    The development of techniques devised for the genetic manipulation of foods poses new risks for children with food allergy (FA). The introduction of foreign allergenic proteins from different foods into previously tolerated foods may trigger allergic reactions, often complicating with anaphylactic shock in a subset of allergic babies. Children with FA, even if subjected to preventative diets, always challenge the risk of developing allergic manifestations after unintentional intake of a non tolerated food in restaurant settings, with relatives or schoolmates, etc, where product labelling is necessarily lacking. The introduction of potentially allergenic proteins into foods generally considered safe for allergic children can be done deliberately, by either substantially altering the food ingredients, or by genetic manipulation which change the composition or transfer allergens, or unintentionally by qualitycontrol failures, due to contaminations in the production process, or to genetic mismanipulation. There is a controversy between multinationals often favored by governments and consumer association resistance, thus an equidistant analysis poses some unprecedented impediments. The importance of FA and the potential of transgenic plants to bring food allergens into the food supply should not be disregarded. The expression in soybeans of a Brazil nut protein resulted in a food allergen ex-pressed in widely used infant formulas, so paving the way to an often reported multinational debacle. Genetic engineering poses innovative ethical and social concerns, as well as serious challenges to the environment, human health, animal welfare, and the future of agriculture. In this paper will be emphasized practical concepts more crucial for pediatricians. PMID:19364084

  11. Physiological Effects Associated with Quinoa Consumption and Implications for Research Involving Humans: a Review.

    PubMed

    Simnadis, Thomas George; Tapsell, Linda C; Beck, Eleanor J

    2015-09-01

    Quinoa is a pseudo-grain consumed as a dietary staple in South America. In recent years, consumer demand for quinoa in the developed world has grown steadily. Its perceived health benefits have been cited as a driving force behind this trend, but there are very few human studies investigating the impact of quinoa consumption. The aim of this review was to identify physiological effects of quinoa consumption with potential for human health. A critical evaluation of animal model studies was conducted. The quality of identified studies was assessed using a methodological quality assessment tool and summative conclusions were drawn to guide the direction of future human research. The majority of studies were of fair quality. Purported physiological effects of quinoa consumption included decreased weight gain, improved lipid profile and improved capacity to respond to oxidative stress. These physiological effects were attributed to the presence of saponins, protein and 20-hydroxyecdysone in the quinoa seed. The implications of these findings are that human studies should investigate the impact of quinoa consumption on weight gain and lipid levels. The role of quinoa as an antioxidant is still unclear and requires further elucidation in animal models.

  12. Physiological Effects Associated with Quinoa Consumption and Implications for Research Involving Humans: a Review.

    PubMed

    Simnadis, Thomas George; Tapsell, Linda C; Beck, Eleanor J

    2015-09-01

    Quinoa is a pseudo-grain consumed as a dietary staple in South America. In recent years, consumer demand for quinoa in the developed world has grown steadily. Its perceived health benefits have been cited as a driving force behind this trend, but there are very few human studies investigating the impact of quinoa consumption. The aim of this review was to identify physiological effects of quinoa consumption with potential for human health. A critical evaluation of animal model studies was conducted. The quality of identified studies was assessed using a methodological quality assessment tool and summative conclusions were drawn to guide the direction of future human research. The majority of studies were of fair quality. Purported physiological effects of quinoa consumption included decreased weight gain, improved lipid profile and improved capacity to respond to oxidative stress. These physiological effects were attributed to the presence of saponins, protein and 20-hydroxyecdysone in the quinoa seed. The implications of these findings are that human studies should investigate the impact of quinoa consumption on weight gain and lipid levels. The role of quinoa as an antioxidant is still unclear and requires further elucidation in animal models. PMID:26249220

  13. The Role of Institutional Research in Institutional Governance. Proceedings, Annual Meeting of the North Carolina Association for Institutional Research (8th, Wrightsville, North Carolina, November 12-24, 1980).

    ERIC Educational Resources Information Center

    Brown, Charles I., Ed.

    Proceedings of the 1980 meeting of the North Carolina Association for Institutional Research, which focused on the role of institutional research in institutional governance, are presented. Contents are as follows: "The Role of Institutional Research in Academic Program Evaluation: An Overview" (Dennis R. Hengstler); "The Role of Institutional…

  14. Institutional Research and Planning in the Next Decade. Proceedings from the Annual Conference of the North East Association for Institutional Research (10th, Hershey, Pennsylvania, October 16-18, 1983). Tenth Anniversary Issue.

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    Proceedings of the 1983 conference of the North East Association for Institutional Research are presented. The contribution of institutional research to university decision making and the topics of student outcomes assessment, retention/attrition studies, marketing/market research, departmental studies, computer and technological applications, and…

  15. Preservation: A Research Library Priority for the 1990s. Minutes of the Meeting of the Association of Research Libraries (111th, Washington, D.C., October 21-22, 1987).

    ERIC Educational Resources Information Center

    Daval, Nicola, Ed.; Merrill-Oldham, Jan, Ed.

    These minutes of the October 1987 ARL (Association of Research Libraries) membership meeting include the following papers on preservation in the research library: (1) "A Challenge for Research Libraries" (David C. Weber); (2) "The Moral Imperative of Conservation" (James H. Billington); (3) "The Role of the Library Director: Wherefore and…

  16. Research.

    ERIC Educational Resources Information Center

    Raudenbush, Stephen

    In May of 1999, the American Academy of Arts and Sciences hosted a conference on ways to improve the scientific quality of educational research. In medicine, thanks to work 40 years ago by 2 researchers, Howard Hyatt and Frederick Mosteller, the commitment of medical professionals to base their diagnoses and prescriptions on clinical trials in…

  17. Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield Personalized Medicine Research Project Biobank.

    PubMed

    Hall, Molly A; Dudek, Scott M; Goodloe, Robert; Crawford, Dana C; Pendergrass, Sarah A; Peissig, Peggy; Brilliant, Murray; McCarty, Catherine A; Ritchie, Marylyn D

    2014-01-01

    Environment-wide association studies (EWAS) provide a way to uncover the environmental mechanisms involved in complex traits in a high-throughput manner. Genome-wide association studies have led to the discovery of genetic variants associated with many common diseases but do not take into account the environmental component of complex phenotypes. This EWAS assesses the comprehensive association between environmental variables and the outcome of type 2 diabetes (T2D) in the Marshfield Personalized Medicine Research Project Biobank (Marshfield PMRP). We sought replication in two National Health and Nutrition Examination Surveys (NHANES). The Marshfield PMRP currently uses four tools for measuring environmental exposures and outcome traits: 1) the PhenX Toolkit includes standardized exposure and phenotypic measures across several domains, 2) the Diet History Questionnaire (DHQ) is a food frequency questionnaire, 3) the Measurement of a Person's Habitual Physical Activity scores the level of an individual's physical activity, and 4) electronic health records (EHR) employs validated algorithms to establish T2D case-control status. Using PLATO software, 314 environmental variables were tested for association with T2D using logistic regression, adjusting for sex, age, and BMI in over 2,200 European Americans. When available, similar variables were tested with the same methods and adjustment in samples from NHANES III and NHANES 1999-2002. Twelve and 31 associations were identified in the Marshfield samples at p<0.01 and p<0.05, respectively. Seven and 13 measures replicated in at least one of the NHANES at p<0.01 and p<0.05, respectively, with the same direction of effect. The most significant environmental exposures associated with T2D status included decreased alcohol use as well as increased smoking exposure in childhood and adulthood. The results demonstrate the utility of the EWAS method and survey tools for identifying environmental components of complex diseases

  18. Spatial Distribution of Uranium in Groundwater and Associated Geologic Material at the NABIR Field Research Center Site, Oak Ridge, Tennessee

    NASA Astrophysics Data System (ADS)

    Phillips, D. H.; Watson, D. B.

    2001-05-01

    The Natural and Accelerated Bioremediation Research Program (NABIR) has established a Field Research Center (FRC) on the Oak Ridge Reservation in Oak Ridge, Tennessee. The FRC provides a site for investigators to conduct research and obtain samples related to in situ bioremediation. This site is in the form of four buried unlined ponds where uranium and other contaminants were disposed in nitric acid for 32 years. In 1984, the ponds were neutralized with limestone, RCRA capped and paved with a parking lot. Analysis of groundwater and geologic material sampled from the site show that uranium is preferentially migrating away from the ponds and towards the nearby Bear Creek. Preferential flow appears to be associated with an ancient buried stream bed and remnant fractures in the saprolite where the uranium content of the groundwater is as high as 7 ppm. Due to the greater discharge of the contaminant source in this portion of the regolith, there is higher weathering of the shallow regolith (top 20 ft)and a greater accumulation of uranium compared to other sections of geologic material surrounding the disposal site.

  19. Poster — Thur Eve — 12: Implementation of a Clinical Lung Tumour High Dose Containment Verification Procedure using Respiratory Cone-Beam CT (4DCBCT) on a Varian TrueBeam Linac

    SciTech Connect

    Beaudry, J.; Bergman, A.

    2014-08-15

    Lung tumours move due to respiratory motion. This is managed during planning by acquiring a 4DCT and capturing the excursion of the GTV (gross tumour volume) throughout the breathing cycle within an IGTV (Internal Gross Tumour Volume) contour. Patients undergo a verification cone-beam CT (CBCT) scan immediately prior to treatment. 3D reconstructed images do not consider tumour motion, resulting in image artefacts, such as blurring. This may lead to difficulty in identifying the tumour on reconstructed images. It would be valuable to create a 4DCBCT reconstruction of the tumour motion to confirm that does indeed remain within the planned IGTV. CBCT projections of a Quasar Respiratory Motion Phantom are acquired in Treatment mode (half-fan scan) on a Varian TrueBeam accelerator. This phantom contains a mobile, low-density lung insert with an embedded 3cm diameter tumour object. It is programmed to create a 15s periodic, 2cm (sup/inf) displacement. A Varian Real-time Position Management (RPM) tracking-box is placed on the phantom breathing platform. Breathing phase information is automatically integrated into the projection image files. Using in-house Matlab programs and RTK (Reconstruction Tool Kit) open-source toolboxes, the projections are re-binned into 10 phases and a 4DCBCT scan reconstructed. The planning IGTV is registered to the 4DCBCT and the tumour excursion is verified to remain within the planned contour. This technique successfully reconstructs 4DCBCT images using clinical modes for a breathing phantom. UBC-BCCA ethics approval has been obtained to perform 4DCBCT reconstructions on lung patients (REB#H12-00192). Clinical images will be accrued starting April 2014.

  20. Research

    ERIC Educational Resources Information Center

    Mathematics Teaching, 1973

    1973-01-01

    Implications for teachers from Piagetian-oriented piagetian-oriented research on problem solving reported in an article by Eleanor Duckworth are presented. Edward de Bono's Children Solve Problems,'' a collection of examples, is also discussed. (MS)

  1. The evaluation of research papers in the XXI century. The Open Peer Discussion system of the World Economics Association

    PubMed Central

    Ietto-Gillies, Grazia

    2012-01-01

    The paper starts with a brief discussion of the traditional peer review (TPR) system of research evaluation, its role, and the criticisms levelled at it. An analysis of specific problems in economics leads to a full discussion of the Open Peer Review (OPR) system developed by the World Economics Association (WEA) and the principles behind it. The system is open in the following two respects: (a) disclosure of names of authors and reviewers; and (b) inclusivity of potential reviewers in terms of paradigmatic approaches, country, and community. The paper then discusses the applicability of the same system to other disciplines. In doing so, it stressed the aims of various evaluation systems and the possible pitfalls of rating systems. It also speculates on the future of journal publication. PMID:22891057

  2. Assessing tobacco use by cancer patients and facilitating cessation: an American Association for Cancer Research policy statement.

    PubMed

    Toll, Benjamin A; Brandon, Thomas H; Gritz, Ellen R; Warren, Graham W; Herbst, Roy S

    2013-04-15

    When diagnosed with cancer, patients can immediately make a meaningful positive impact on their health by stopping their tobacco use. Scientific evidence clearly shows that tobacco use in patients with cancer leads to poorer outcomes. The specific biological processes driving tobacco consumption's interference in cancer therapy are the subject of continuing research, but the evidence is clear that tobacco use in patients with cancer leads to decreased treatment efficacy and safety, decreased survival, decreased quality of life, increased treatment-related toxicity, and increased risk of cancer recurrence and second primary tumors. Data suggest that tobacco cessation can improve outcomes and survival in patients with cancer, yet full execution of evidence-based cessation interventions is infrequent in oncology settings. Therefore, both improved provision of cessation assistance to all patients with cancer who use tobacco or have recently quit and further study of the deleterious effects of tobacco use and benefits of tobacco cessation on cancer progression and treatment are needed and recommended by the American Association for Cancer Research. Progress on both fronts begins with universal assessment and documentation of tobacco use as a standard of quality cancer care regardless of treatment setting and will be further facilitated through the development of reliable, valid, and standard measures of tobacco use, incorporation of evidence-based procedures into quality and accreditation procedures, and the development of appropriate training, clinical infrastructure, and incentives for delivery of tobacco cessation interventions.

  3. A Review of Research on Health Outcomes for Workers, Home and Host Communities of Population Mobility Associated with Extractive Industries.

    PubMed

    Carney, Jason G; Gushulak, Brian D

    2016-06-01

    With a growing awareness of the association between extractive industries, the nature of work in remote locations, population mobility and health status, there is a need to advance an evidence-based approach to ensuring the health of migrant and mobile populations, and the home and host communities with whom they interact. Through a narrative synthesis of peer-reviewed and grey literature, this review examines what is known, and the nature of research activity concerning the range of health impacts determined by the social conditions inherent with population mobility alongside mining and extractive industries; and the extent to which health outcomes impact on workers, and home and host communities. While much of the literature reviewed in the study considered health in a traditional disease or illness based approach, it is clear that many risk factors for the health of mobile workers in the sector reflect broader social determinants. To support the mitigation of individual and population vulnerability to infectious disease endemics, consideration of both the etiology and the social conditions that give rise to adverse health outcomes is required, including an improvement to workers' living conditions, the expansion of diagnostic and medical services, and an approach that ensures the right to health for mobile populations. To further improve upon the rich body of research, resources are required to implement robust data collection including epidemiological surveillance, outbreak monitoring and investigation, and the long term tracking of standardized health information at both origin locations and destination communities. PMID:26902231

  4. Nurses’ research utilization two years after graduation—a national survey of associated individual, organizational, and educational factors

    PubMed Central

    2012-01-01

    Background Nurses’ research utilization (RU) as part of evidence-based practice is strongly emphasized in today’s nursing education and clinical practice. The primary aim of RU is to provide high-quality nursing care to patients. Data on newly graduated nurses’ RU are scarce, but a predominance of low use has been reported in recent studies. Factors associated with nurses’ RU have previously been identified among individual and organizational/contextual factors, but there is a lack of knowledge about how these factors, including educational ones, interact with each other and with RU, particularly in nurses during the first years after graduation. The purpose of this study was therefore to identify factors that predict the probability for low RU among registered nurses two years after graduation. Methods Data were collected as part of the LANE study (Longitudinal Analysis of Nursing Education), a Swedish national survey of nursing students and registered nurses. Data on nurses’ instrumental, conceptual, and persuasive RU were collected two years after graduation (2007, n = 845), together with data on work contextual factors. Data on individual and educational factors were collected in the first year (2002) and last term of education (2004). Guided by an analytic schedule, bivariate analyses, followed by logistic regression modeling, were applied. Results Of the variables associated with RU in the bivariate analyses, six were found to be significantly related to low RU in the final logistic regression model: work in the psychiatric setting, role ambiguity, sufficient staffing, low work challenge, being male, and low student activity. Conclusions A number of factors associated with nurses’ low extent of RU two years postgraduation were found, most of them potentially modifiable. These findings illustrate the multitude of factors related to low RU extent and take their interrelationships into account. This knowledge might serve as useful input in

  5. The Joy of Teaching Literacy. The Thirty-Fourth Yearbook: A Double Peer Reviewed Publication of the Association of Literacy Educators and Researchers

    ERIC Educational Resources Information Center

    Marin, Linda, Ed.; Boggs, Merry, Ed.; Szabo, Susan, Ed.; Morrision, Timothy, Ed.; Garza-Garcia, Lizabeth, Ed.

    2012-01-01

    The Association of Literacy Educators and Researchers (ALER) Yearbook, Volume 34, includes papers presented at the annual conference, which have gone through a double peer review process. It also includes the Presidential Address and the keynote addresses given at the conference. For ALER's 55th annual meeting, the Association of Literacy…

  6. Confronting the Challenges of the Digital Era. Proceedings of the Membership Meeting of the Association of Research Libraries (133rd, Washington, DC, October 14-16, 1998).

    ERIC Educational Resources Information Center

    Bhalla, Nicole, Ed.; Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

    The 133rd meeting of the Association of Research Libraries (ARL) focused on strategies for confronting critical challenges associated with the digital era and for fostering understanding from university leaders and supporters regarding the resources needed to perform successfully in this print plus digital environment. Program Session I,…

  7. Renewing the ARL Agenda. Proceedings of the Annual Meeting of the Association of Research Libraries (125th, Washington, DC, October 19-21, 1994).

    ERIC Educational Resources Information Center

    Page, Jennifer, Ed.; Brennan, Patricia, Ed.

    The 125th meeting of the Association of Research Libraries (ARL) reviewed the mission statement, goals, and objectives of the Association. Major themes from the review process included the effect of technology on access and preservation; the critical need to develop measures of library effectiveness and performance; and the importance of…

  8. [Current modalities and concepts on access and use of biospecimen samples and associated data for research from human biobanks].

    PubMed

    Siddiqui, Roman; Semler, Sebastian Claudius

    2016-03-01

    It is accepted worldwide that biospecimen and data sharing (BDS) play an essential role for the future of medical research to improve diagnostics and prognostics, e.g. by validated biomarkers. BDS is also pivotal to the development of new therapeutic treatments and for the improvement of population health. Human biobanks can generate an added value to this need by providing biospecimens and/or associated data to researchers. An inspection of several examples of epidemiological as well as clinical/disease-oriented biobanks in Germany shows that best practice procedures (BPP) that are internationally agreed on are being installed for biospecimen and/or data access. In general, fair access is aimed at requiring a written application by the requesting scientist, which is then peer-reviewed for scientific and ethical validity by the Biobank. Applied BPP take into account (i) patient education/agreement according to the informed consent model, (ii) privacy protection, (iii) intellectual property rights, the (iv) notification obligation of health-related findings (including incidental findings), the (v) use of material (MTA) and data transfer agreements (DTA) for mutual legal security, the avoidance of conflicts of interests, as well as for cost recovery/fee for service as a basis for sustainability of the biobank. BPP are rooted in the self-regulation efforts of life sciences and are supported by parent ethics committees in Germany. Central biobank registries displaying aggregated information on biospecimens stored and the research foci constitute an important tool to make biobanks that are scattered across the country visible to each other, and, can thus promote access to hitherto unknown biospecimen and data resources. PMID:26809822

  9. National Libraries' Leadership Roles and Responsibilities. Minutes of the Semiannual Meeting of the Association of Research Libraries (115th, Bethesda, Maryland, October 18-20, 1989).

    ERIC Educational Resources Information Center

    Harvey, Diane, Ed.

    This membership meeting of the Association of Research Libraries (ARL) opened with an overview of the challenges facing research libraries and the relationships between the three U.S. national libraries and the members of ARL by Sidney Verba of Harvard University. The directors of the national libraries then spoke on their current programs and…

  10. Proceedings of the Annual Meeting of the Mid-South Educational Research Association (23rd, Nashville, Tennessee, November 9-11, 1994).

    ERIC Educational Resources Information Center

    Petry, John R., Ed.; And Others

    This volume of proceedings of the Mid-South Educational Research Association's 23rd annual meeting contains abstracts of discussion sessions, display sessions, symposia, and training sessions. Over 320 abstracts and annotations are included, for sessions that cover the whole range of educational research. Assessment and measurement, educational…

  11. National Association for Research in Science Teaching Annual Meeting, Abstracts of Presented Papers (53rd, Boston, Massachusetts, April 11-13, 1980).

    ERIC Educational Resources Information Center

    White, Arthur L., Ed.

    This publication contains abstracts of papers presented at the 53rd annual meeting of the National Association for Research in Science Teaching (NARST), held in Boston, Massachusetts, April 11-13, 1980. Papers relate to research techniques, learning, cognitive development, instruction, science curriculum, teacher education (preservice, inservice)…

  12. Science and Math Education Information Report: National Association for Research in Science Teaching. 43rd Annual Meeting. Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    ERIC Information Analysis Center for Science Education, Columbus, OH.

    This report contains abstracts of most of the research papers in science education presented at the 43rd annual meeting of the National Association for Research in Science Teaching in Minneapolis, Minnesota, March 5-8, 1970. Also included are the topics and names of participants of several symposia at the conference. The abstracts are organized…

  13. National Association for Research in Science Teaching, Annual Meeting (66th, Atlanta, Georgia, April 15-19, 1993). Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    Gallard, Alejandro Jose, Ed.; De Albuquerque, Haroldo Guerreiro, Ed.

    This book provides titles, author information, and abstracts of presented papers at the 1993 National Association of Research in Science Teaching Conference. The abstracts are divided into the following sections: (1) Alternative Assessment; (2) Approaches to Research; (3) Conceptual Change; (4) Gender and Equity; (5) History, Philosophy, and…

  14. IFLA General Conference, 1985. International Association of Law Libraries (IALL) Round-Table on Access to Information in International Legal Research. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations, The Hague (Netherlands).

    Papers on international access to information pertaining to legal research, which were presented at the 1985 conference of the International Federation of Library Associations (IFLA) include: (1) "Materials of European Intergovernmental Organizations and Their Accessibility through Available Research Tools" (Irene Berkey, Northwestern University…

  15. Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (31st, Orlando, FL, 2008)

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2008-01-01

    For the thirty-first year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) sponsored the publication of these Proceedings. Papers were presented at the annual AECT Convention in Orlando, Florida. This year's Proceedings has two sections--Section 1 includes research and development papers and…

  16. From Joint Experimentation to Laissez-Faire: Transdisciplinary Innovation Research for the Institutional Strengthening of a Water Users Association in Khorezm, Uzbekistan

    ERIC Educational Resources Information Center

    Djanibekov, Nodir; Hornidge, Anna-Katharina; Ul-Hassan, Mehmood

    2012-01-01

    Purpose: This article assesses a participatory action and innovation research experience, in which project researchers, farmers and staff members of a local water users association (WUA) came together to: (a) jointly test and adapt a social mobilization and institutional strengthening approach according to the local context, and by doing so, to…

  17. Redefining Higher Education. Proceedings of the Meeting of the Association of Research Libraries (129th, Washington, DC, October 16-18, 1996).

    ERIC Educational Resources Information Center

    Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

    The 129th meeting of the Association of Research Libraries (ARL) focused on anticipating the future of higher education in North America and identifying responses from research libraries that will contribute to emerging agendas for change. An opening session (convened by Nancy Cline, ARL Presiding President) began the meeting. The first session,…

  18. ARL Statistics, 1999-2000: A Compilation of Statistics from the One Hundred and Twenty-Two Members of the Association of Research Libraries.

    ERIC Educational Resources Information Center

    Kyrillidou, Martha, Comp.; Young, Mark, Comp.

    This is the latest in a series of annual publications that describe collections, staffing, expenditures, and service activities for the 122 member libraries of the Association of Research Libraries (ARL). Of these, 112 are universities libraries; the remaining 10 are public, governmental, and private research libraries. ARL member libraries are…

  19. Arts and Learning SIG Proceedings: American Educational Research Association Annual Meeting (New Orleans, Louisiana, April 23-27, 1984). Volume 2.

    ERIC Educational Resources Information Center

    Koroscik, Judith S., Ed.; Barrett, Terry, Ed.

    Sixteen conference papers representing diverse topics concerning research in the arts and presented as part of the 1984 Arts and Learning Special Interest Group (SIG) program of the American Educational Research Association are presented in the second of two volumes. Papers presented include: "First Graders' Conversations about Art Making: Social…

  20. 1991 AAIR Forum. Refereed Proceedings of the Conference of the Australasian Association for Institutional Research (AAIR) (2nd, Melbourne, Victoria, Australia, October 1-3, 1991).

    ERIC Educational Resources Information Center

    Swinburne Inst. of Technology, Hawthorn, Victoria (Australia).

    The Australasian Association for Institutional Research (AAIR) conference provided a comprehensive coverage of issues, concepts, and techniques in the areas of planning, data analysis and research, and related aspects of management support in tertiary education. Refereed papers from the conference include: (1) "Changes in Student Approaches to…

  1. ARL Statistics 2002-03: A Compilation of Statistics from the One Hundred and Twenty-Three Members of the Association of Research Libraries

    ERIC Educational Resources Information Center

    Kyrillidou, Martha, Comp.; Young, Mark, Comp.

    2004-01-01

    This document is the latest in a series of annual publications that describe collections, staffing, expenditures, and service activities for the 123 members of the Association of Research Libraries (ARL). Of these, 113 are university libraries, the remaining 10 are public, governmental, and nonprofit research libraries. Data reported by member…

  2. Energies for Transition. Proceedings of the National Conference of the Association of College and Research Libraries (4th, Baltimore, Maryland, April 9-12, 1986).

    ERIC Educational Resources Information Center

    Nitecki, Danuta A., Ed.

    This proceedings of the 1986 conference of the Association of College and Research Libraries contains 60 papers--44 position papers, 7 research reports, and 9 idea briefs--dealing with the issue of transitions facing librarians and ways to respond to these transitions through both formal and informal means. Papers are organized under eight broad…

  3. International Federation of Library Associations Annual Conference Papers. General Research Libraries Division: Parliamentary Libraries and National Libraries Sections (47th, Leipzig, East Germany, August 17-22, 1981).

    ERIC Educational Resources Information Center

    Gude, Gilbert; And Others

    This set of papers presented to the General Research Libraries Division of the International Federation of Library Associations (IFLA) during its 47th annual conference (1981) includes: "The Effect of the Introduction of Computers on Library and Research Staff," by Gilbert Gude; "Libraries as Information Service Agencies (IVS)," by Franz Georg…

  4. Arts and Learning Research, 1996-1997. The Journal of the Arts and Learning Special Interest Group of the American Educational Research Association (New York, New York, April 1996).

    ERIC Educational Resources Information Center

    Diket, Read M., Ed.; Klein, Sheri R., Ed.

    1997-01-01

    The papers gathered in this volume were presented at the 1996 meeting of the American Educational Research Association, mostly at programs of the Arts and Learning Special Interest Group. Papers in the volume focus on research in the arts in the areas of profiles of learning and assessment (section 1), community-based art education (section 2),…

  5. Research in Science Education, 1994. Selected Refereed Papers from the Annual Conference of the Australasian Science Education Research Association (25th, Hobart, Tasmania, Australia, July 10-13, 1994).

    ERIC Educational Resources Information Center

    Gardner, Paul L., Ed.

    1994-01-01

    This volume contains 41 papers, 10 abstracts/research notes, and an after-dinner speech "The Book of Genesis and the Chronicles of the People of ASERA (Australasian Science Education Research Association). Paper titles include: "Improving students' understanding of carbohydrate metabolism in first-year Biochemistry at tertiary level"; "Students'…

  6. Sailing into the New Millennium: Charting the Course for Institutional Research. North East Association for Institutional Research Annual Conference Proceedings (26th, Newport, Rhode Island, November 13-16, 1999).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    This proceedings contains papers from the 1999 annual conference of the North East Association for Institutional Research. The papers are: (1) "A Marketing Research Program for Commuter Colleges" (Michelle S. Appel and Craig A. Clagett); (2) "Where Do I Start? Determining Institutional Information Needs beyond Mandated Reporting" (Michelle S.…

  7. Doing Institutional Research: A Focus on Professional Development. Papers from the Annual Meeting of the North East Association for Institutional Research (9th, Durham, New Hampshire, October 17-19, 1982).

    ERIC Educational Resources Information Center

    Green, Diana M., Ed.

    Institutional research that focuses on professional development is addressed in 35 papers from the 1982 meeting of the North East Association for Institutional Research. Titles and authors include the following: "Modeling College Student Adjustment and Retention for the Individual Institution" (Norman D. Aitken); "The Development Saga of an…

  8. Handbook of Research for Educational Communications and Technology. A Project of the Association for Educational Communications and Technology (AECT).

    ERIC Educational Resources Information Center

    Jonassen, David H., Ed.

    This handbook provides an overview of research in the field of educational communications and technology. The handbook may be used to familiarize students and researchers with a domain of research in this field prior to their own research, or may be used as a guide for selecting research topics or methodologies. The book consists of 42 papers by…

  9. SU-E-J-13: Six Degree of Freedom Image Fusion Accuracy for Cranial Target Localization On the Varian Edge Stereotactic Radiosurgery System: Comparison Between 2D/3D and KV CBCT Image Registration

    SciTech Connect

    Xu, H; Song, K; Chetty, I; Kim, J; Wen, N

    2015-06-15

    Purpose: To determine the 6 degree of freedom systematic deviations between 2D/3D and CBCT image registration with various imaging setups and fusion algorithms on the Varian Edge Linac. Methods: An anthropomorphic head phantom with radio opaque targets embedded was scanned with CT slice thicknesses of 0.8, 1, 2, and 3mm. The 6 DOF systematic errors were assessed by comparing 2D/3D (kV/MV with CT) with 3D/3D (CBCT with CT) image registrations with different offset positions, similarity measures, image filters, and CBCT slice thicknesses (1 and 2 mm). The 2D/3D registration accuracy of 51 fractions for 26 cranial SRS patients was also evaluated by analyzing 2D/3D pre-treatment verification taken after 3D/3D image registrations. Results: The systematic deviations of 2D/3D image registration using kV- kV, MV-kV and MV-MV image pairs were within ±0.3mm and ±0.3° for translations and rotations with 95% confidence interval (CI) for a reference CT with 0.8 mm slice thickness. No significant difference (P>0.05) on target localization was observed between 0.8mm, 1mm, and 2mm CT slice thicknesses with CBCT slice thicknesses of 1mm and 2mm. With 3mm CT slice thickness, both 2D/3D and 3D/3D registrations performed less accurately in longitudinal direction than thinner CT slice thickness (0.60±0.12mm and 0.63±0.07mm off, respectively). Using content filter and using similarity measure of pattern intensity instead of mutual information, improved the 2D/3D registration accuracy significantly (P=0.02 and P=0.01, respectively). For the patient study, means and standard deviations of residual errors were 0.09±0.32mm, −0.22±0.51mm and −0.07±0.32mm in VRT, LNG and LAT directions, respectively, and 0.12°±0.46°, −0.12°±0.39° and 0.06°±0.28° in RTN, PITCH, and ROLL directions, respectively. 95% CI of translational and rotational deviations were comparable to those in phantom study. Conclusion: 2D/3D image registration provided on the Varian Edge radiosurgery, 6 DOF

  10. Child Well-Being in Same-Sex Parent Families: Review of Research Prepared for American Sociological Association Amicus Brief.

    PubMed

    Manning, Wendy D; Fettro, Marshal Neal; Lamidi, Esther

    2014-08-01

    Recent legal cases before the Supreme Court of the United States were challenging federal definitions of marriage created by the Defense of Marriage Act and California's voter approved Proposition 8 which limited marriage to different-sex couples only. Social science literature regarding child well-being was being used within these cases, and the American Sociological Association sought to provide a concise evaluation of the literature through an amicus curiae brief. The authors were tasked in the assistance of this legal brief by reviewing literature regarding the well-being of children raised within same-sex parent families. This article includes our assessment of the literature, focusing on those studies, reviews and books published within the past decade. We conclude that there is a clear consensus in the social science literature indicating that American children living within same-sex parent households fare just, as well as those children residing within different-sex parent households over a wide array of well-being measures: academic performance, cognitive development, social development, psychological health, early sexual activity, and substance abuse. Our assessment of the literature is based on credible and methodologically sound studies that compare well-being outcomes of children residing within same-sex and different-sex parent families. Differences that exist in child well-being are largely due to socioeconomic circumstances and family stability. We discuss challenges and opportunities for new research on the well-being of children in same-sex parent families. PMID:25018575

  11. Child Well-Being in Same-Sex Parent Families: Review of Research Prepared for American Sociological Association Amicus Brief.

    PubMed

    Manning, Wendy D; Fettro, Marshal Neal; Lamidi, Esther

    2014-08-01

    Recent legal cases before the Supreme Court of the United States were challenging federal definitions of marriage created by the Defense of Marriage Act and California's voter approved Proposition 8 which limited marriage to different-sex couples only. Social science literature regarding child well-being was being used within these cases, and the American Sociological Association sought to provide a concise evaluation of the literature through an amicus curiae brief. The authors were tasked in the assistance of this legal brief by reviewing literature regarding the well-being of children raised within same-sex parent families. This article includes our assessment of the literature, focusing on those studies, reviews and books published within the past decade. We conclude that there is a clear consensus in the social science literature indicating that American children living within same-sex parent households fare just, as well as those children residing within different-sex parent households over a wide array of well-being measures: academic performance, cognitive development, social development, psychological health, early sexual activity, and substance abuse. Our assessment of the literature is based on credible and methodologically sound studies that compare well-being outcomes of children residing within same-sex and different-sex parent families. Differences that exist in child well-being are largely due to socioeconomic circumstances and family stability. We discuss challenges and opportunities for new research on the well-being of children in same-sex parent families.

  12. Child Well-Being in Same-Sex Parent Families: Review of Research Prepared for American Sociological Association Amicus Brief

    PubMed Central

    Manning, Wendy D.; Fettro, Marshal Neal; Lamidi, Esther

    2014-01-01

    Recent legal cases before the Supreme Court of the United States were challenging federal definitions of marriage created by the Defense of Marriage Act and California’s voter approved Proposition 8 which limited marriage to different-sex couples only. Social science literature regarding child well-being was being used within these cases, and the American Sociological Association sought to provide a concise evaluation of the literature through an amicus curiae brief. The authors were tasked in the assistance of this legal brief by reviewing literature regarding the well-being of children raised within same-sex parent families. This article includes our assessment of the literature, focusing on those studies, reviews and books published within the past decade. We conclude that there is a clear consensus in the social science literature indicating that American children living within same-sex parent households fare just, as well as those children residing within different-sex parent households over a wide array of well-being measures: academic performance, cognitive development, social development, psychological health, early sexual activity, and substance abuse. Our assessment of the literature is based on credible and methodologically sound studies that compare well-being outcomes of children residing within same-sex and different-sex parent families. Differences that exist in child well-being are largely due to socioeconomic circumstances and family stability. We discuss challenges and opportunities for new research on the well-being of children in same-sex parent families. PMID:25018575

  13. Junior and Community College Research, Texas, 1980-81. The 1981 Research Report to the Texas Association of Junior and Community College Instructional Administrators.

    ERIC Educational Resources Information Center

    Texas Association of Junior and Community Coll. Instructional Administrators.

    Reports and abstracts are presented for research conducted during 1981 on community college education in Texas. Four institutional research reports are provided first: an evaluation of the effectiveness of the developmental studies program at North Harris County College; a study of retention patterns at Amarillo College by Stanley Adelman and Kay…

  14. Navigating the Literacy Waters: Research, Praxis, and Advocacy. The Twenty-Ninth Yearbook: A Peer Reviewed Publication of the College Reading Association. [Papers from the College Reading Association Conference, 2006

    ERIC Educational Resources Information Center

    Foote, Martha M., Ed.; Szabo, Susan, Ed.; Falk-Ross, Francine, Ed.; Sampson, Mary Beth, Ed.

    2008-01-01

    This book presents a selection of the research and papers presented at the 50th Annual Meeting of the College Reading Association in Pittsburgh, Pennsylvania in October, 2006. This Yearbook begins with Karen Bromley's presidential address, which explored the future of writing by discussing four predictions: the notion that pens and pencils will be…

  15. Access and benefits sharing of genetic resources and associated traditional knowledge in northern Canada: understanding the legal environment and creating effective research agreements

    PubMed Central

    Geary, Janis; Jardine, Cynthia G.; Guebert, Jenilee; Bubela, Tania

    2013-01-01

    Background Research in northern Canada focused on Aboriginal peoples has historically benefited academia with little consideration for the people being researched or their traditional knowledge (TK). Although this attitude is changing, the complexity of TK makes it difficult to develop mechanisms to preserve and protect it. Protecting TK becomes even more important when outside groups become interested in using TK or materials with associated TK. In the latter category are genetic resources, which may have commercial value and are the focus of this article. Objective This article addresses access to and use of genetic resources and associated TK in the context of the historical power-imbalances in research relationships in Canadian north. Design Review. Results Research involving genetic resources and TK is becoming increasingly relevant in northern Canada. The legal framework related to genetic resources and the cultural shift of universities towards commercial goals in research influence the environment for negotiating research agreements. Current guidelines for research agreements do not offer appropriate guidelines to achieve mutual benefit, reflect unequal bargaining power or take the relationship between parties into account. Conclusions Relational contract theory may be a useful framework to address the social, cultural and legal hurdles inherent in creating research agreements. PMID:23986896

  16. Hemagglutinating/Hemolytic activities in extracts of marine invertebrates from the Brazilian coast and isolation of two lectins from the marine sponge Cliona varians and the sea cucumber Holothuria grisea.

    PubMed

    Moura, Raniere M; Melo, Arthur A; Carneiro, Rômulo F; Rodrigues, Cícera R F; Delatorre, Plínio; Nascimento, Kyria S; Saker-Sampaio, Silvana; Nagano, Celso S; Cavada, Benildo S; Sampaio, Alexandre H

    2015-01-01

    Twenty species of marine invertebrates from the Brazilian coast were screened for hemagglutinating/hemolytic activity. In at least twelve tested species, hemagglutinating activity was different for different blood types, suggesting the presence of lectins. Extracts from four species showed hemolytic activity. Two new lectins were purified from the marine sponge Cliona varians (CvL-2) and sea cucumber Holothuria grisea (HGL). CvL-2 was able to agglutinate rabbit erythrocytes and was inhibited by galactosides. The hemagglutinating activity was optimal in pH neutral and temperatures below 70 °C. CvL-2 is a trimeric protein with subunits of 175 kDa. On the other hand, HGL showed both hemagglutinating and hemolytic activity in human and rabbit erythrocytes, but hemolysis could be inhibited by osmotic protection, and agglutination was inhibited by mucin. HGL was stable in pH values ranging from 4 to 10 and temperatures up to 90 °C. In electrophoresis and gel filtration, HGL was a monomeric protein with 15 kDa. CvL-2 and HGL showed different levels of toxicity to Artemia naplii. CvL-2 showed LC50 of 850.1 μg/mL, whereas HGL showed LC50 of 9.5 µg/mL. PMID:25993359

  17. Effects of Different Analysis Strategies on Paired Associative Stimulation. A Pooled Data Analysis from Three Research Labs.

    PubMed

    Lahr, Jacob; Paßmann, Sven; List, Jonathan; Vach, Werner; Flöel, Agnes; Klöppel, Stefan

    2016-01-01

    Paired associative stimulation (PAS) is a widely used transcranial magnetic stimulation (TMS) paradigm to non-invasively induce synaptic plasticity in the human brain in vivo. Altered PAS-induced plasticity has been demonstrated for several diseases. However, researchers are faced with a high inter- and intra-subject variability of the PAS response. Here, we pooled original data from nine PAS studies from three centers and analyzed the combined dataset of 190 healthy subjects with regard to age dependency, the role of stimulation parameters and the effect of different statistical methods. We observed no main effect of the PAS intervention over all studies (F(2;362) = 0.44; p = 0.644). The rate of subjects showing the expected increase of motor evoked potential (MEP) amplitudes was 53%. The PAS effect differed significantly between studies as shown by a significant interaction effect (F(16;362) = 1.77; p = 0.034) but post-hoc testing did not reveal significant effects after correction for multiple tests. There was a trend toward increased variability of the PAS effect in older subjects. Acquisition parameters differed across studies but without systematically influencing changes in MEP-size. The use of post/baseline quotients systematically indicated stronger PAS effects than post/baseline difference or the logarithm of the post/baseline quotient. The non-significant PAS effects across studies and a wide range of responder rates between studies indicate a high variability of this method. We were thus not able to replicate findings from a previous meta-analysis showing robust effects of PAS. No pattern emerged regarding acquisition parameters that at this point could guide future studies to reduce variability and help increase response rate. For future studies, we propose to report the responder rate and recommend the use of the logarithmized post/baseline quotient for further analyses to better address the possibility that results are driven by few extreme cases

  18. Effects of Different Analysis Strategies on Paired Associative Stimulation. A Pooled Data Analysis from Three Research Labs

    PubMed Central

    List, Jonathan; Vach, Werner; Flöel, Agnes; Klöppel, Stefan

    2016-01-01

    Paired associative stimulation (PAS) is a widely used transcranial magnetic stimulation (TMS) paradigm to non-invasively induce synaptic plasticity in the human brain in vivo. Altered PAS-induced plasticity has been demonstrated for several diseases. However, researchers are faced with a high inter- and intra-subject variability of the PAS response. Here, we pooled original data from nine PAS studies from three centers and analyzed the combined dataset of 190 healthy subjects with regard to age dependency, the role of stimulation parameters and the effect of different statistical methods. We observed no main effect of the PAS intervention over all studies (F(2;362) = 0.44; p = 0.644). The rate of subjects showing the expected increase of motor evoked potential (MEP) amplitudes was 53%. The PAS effect differed significantly between studies as shown by a significant interaction effect (F(16;362) = 1.77; p = 0.034) but post-hoc testing did not reveal significant effects after correction for multiple tests. There was a trend toward increased variability of the PAS effect in older subjects. Acquisition parameters differed across studies but without systematically influencing changes in MEP-size. The use of post/baseline quotients systematically indicated stronger PAS effects than post/baseline difference or the logarithm of the post/baseline quotient. The non-significant PAS effects across studies and a wide range of responder rates between studies indicate a high variability of this method. We were thus not able to replicate findings from a previous meta-analysis showing robust effects of PAS. No pattern emerged regarding acquisition parameters that at this point could guide future studies to reduce variability and help increase response rate. For future studies, we propose to report the responder rate and recommend the use of the logarithmized post/baseline quotient for further analyses to better address the possibility that results are driven by few extreme cases

  19. Building Literacy Communities. The Thirty-Second Yearbook: A Doubled Peer Reviewed Publication of the Association of Literacy Educators and Researchers

    ERIC Educational Resources Information Center

    Szabo, Susan, Ed.; Morrison, Timothy, Ed.; Martin, Linda, Ed.; Boggs, Merry, Ed.; Raine, I. LaVerne, Ed.

    2010-01-01

    For its 53rd annual meeting, the Association of Educators and Researchers met in Charlotte, North Carolina at the Marriott Charlotte City Center. This year's conference theme was "Building Literacy Communities", which was also used as the title for this year's Yearbook, Volume 32. This organization has long been the home of some of the nation's…

  20. Technology and the Future of Scholarly Exchange. Minutes of the Annual Meeting of the Association of Research Libraries (114th, Providence, Rhode Island, May 10-12, 1989).

    ERIC Educational Resources Information Center

    Harvey, Diane, Ed.

    This membership meeting of the Association of Research Libraries (ARL) focused on the impact of the new information technologies on scholarly exchange. The program was organized into two sessions comprising 11 papers in all. In the first session, three influential leaders presented papers exploring different aspects of the conference topic. In the…

  1. National Association for Research in Science Teaching Annual Conference (64th, Lake Geneva, Wisconsin, April 7-10, 1991). Abstracts of Presented Papers.

    ERIC Educational Resources Information Center

    National Association for Research in Science Teaching.

    Abstracts of most of the papers, symposia, discussion groups, round tables, and poster sessions presented at the 64th conference of the National Association for Research in Science Teaching (NARST) are provided. Subject areas addressed are as follows: teacher knowledge, cognitive development, conceptual change, curriculum issues, reform in science…

  2. National Association for Research in Science Teaching 51st Annual Meeting, Abstracts of Presented Papers (Toronto, Ontario, Canada, March 31 - April 2, 1978).

    ERIC Educational Resources Information Center

    White, Arthur L., Ed.

    This publication provides abstracts of papers presented at the 51st annual meeting of the National Association for Research in Science Teaching (NARST) held in Toronto, Canada from March 31 to April 2, 1978. Entries represent a wide range of topics in science education including: cognitive development, teacher education, student behaviors,…

  3. Proceedings of the Annual Meeting of the Mid-South Educational Research Association (28th, Point Clear, Alabama, November 17-19, 1999).

    ERIC Educational Resources Information Center

    Petry, John R., Ed.; Allen, Lorraine, Ed.; Brignole, Mary, Ed.

    This volume contains abstracts of the more than 300 discussion papers, symposia, displays, and training sessions presented at the Mid-South Educational Research Association (MSERA) 1999 annual meeting. Papers deal with elementary, secondary, and higher education and cover a broad spectrum of educational issues. Although many papers focus on the…

  4. National Association for Research in Science Teaching 52nd Annual Meeting, Abstracts of Presented Papers (Atlanta, Georgia, March 21-23, 1979).

    ERIC Educational Resources Information Center

    White, Arthur L., Ed.

    This publication contains abstracts of papers presented at the 52nd annual meeting of the National Association for Research in Science Teaching (NARST), Atlanta, Georgia, March 21-23, 1979. Papers relate to science teacher education (preservice and inservice), cognitive development, learning, instruction, teacher and student behaviors, research…

  5. National Association for Research in Science Teaching Annual Meeting, Abstracts of Presented Papers (55th, Lake Geneva, Wisconsin, April 5-8, 1982).

    ERIC Educational Resources Information Center

    White, Arthur L., Ed.; Blosser, Patricia E., Ed.

    Abstracts of most of the papers presented at the 55th annual meeting of the National Association for Research in Science Teaching (NARST), held at the Abbey, Lake Geneva, WI, April 5-8, 1982 have been collected in this publication. Papers relate to such topics as teacher education: preservice and inservice, cognitive development, research…

  6. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (27th, Chicago, Illinois, 2004). Volume 2

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2004-01-01

    For the twenty-seventh year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Chicago, Illinois. The Proceedings of AECT's Convention are published in two…

  7. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (29th, Dallas, Texas, 2006). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2006-01-01

    For the twenty-ninth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Orlando, Florida. The Proceedings of AECT's Convention are published in two…

  8. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (28th, Orlando, Florida, 2005). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2005-01-01

    For the twenty-eighth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Orlando, Florida. The Proceedings of AECT's Convention are published in two…

  9. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (25th, Dallas, Texas, 2002). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2002-01-01

    For the twenty-fifth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Dallas, TX. The Proceedings of AECT's Convention are published in two volumes.…

  10. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (26th, Anaheim, California, 2003). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2003-01-01

    For the twenty-sixth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Anaheim, CA. The Proceedings of AECT's Convention are published in two volumes.…

  11. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (26th, Anaheim, California, 2003). Volume 2

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2003-01-01

    For the twenty-sixth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. This is Volume 2 of the 26th Annual Proceedings of Selected Papers On the Practice of Educational Communications and Technology presented at the National AECT…

  12. AIR 1981-82. Forum 1981 Proceedings: Toward 2001: The IR Perspective (Minneapolis, Minnesota, May 17-20). The Association for Institutional Research Directory, 1981-82.

    ERIC Educational Resources Information Center

    Association for Institutional Research.

    Proceedings of the 1981 Association for Institutional Research (AIR) Forum and the 1981-82 AIR Directory are presented in a single volume. General session addresses and authors from the forum are as follows: "Some Possible Revolutions by 2001" (Michael Marien); "Information, the Non-Depletive Resource" (John W. Lacey); "What's Higher about Higher…

  13. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (29th, Dallas, Texas, 2006). Volume 2

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2006-01-01

    For the twenty-ninth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Orlando, Florida. The Proceedings of AECT's Convention are published in two…

  14. Gateway to the Pacific Rim: Information Resources for the 21st Century. Association of Research Libraries, Minutes of the Meeting (122nd, Honolulu, Hawaii, May 1993).

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC.

    High economic growth and growing movements toward democratic political systems are reshaping the Pacific countries, and these movements will have profound implications for libraries. The program of the meeting of the Association of Research Libraries was devoted to the cultures, societies, and libraries of the Pacific Rim. Program Session I,…

  15. Exploring the World of Literacy. The Thirty-Sixth Yearbook: A Doubled Peer-Reviewed Publication of the Association of Literacy Educators and Researchers

    ERIC Educational Resources Information Center

    Szabo, Susan, Ed.; Haas, Leslie, Ed.; Vasinda, Sheri, Ed.

    2014-01-01

    For their 57th annual conference, the Association of Literacy Educators and Researchers (ALER) met in Dallas, Texas at Addison Marriott Quorum by the Galleria. This year's conference theme was Exploring the World of Literacy, which was also used as the title for this year's Yearbook, Volume 36. Included are double-peer reviewed papers,…

  16. Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (35th, Louisville, Kentucky, 2012). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2012-01-01

    For the thirty-fifth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the national AECT Convention in Louisville, Kentucky. The Proceedings of AECT's Convention are published in…

  17. International Conference of the Australasian Association of Institutional Research (3rd, Auckland, New Zealand, November 25-27, 1992). Selected Papers.

    ERIC Educational Resources Information Center

    Ng, Gan Che, Ed.; And Others

    1993-01-01

    Eight papers presented at the Third International Conference of the Australasian Association of Institutional Research (AAIR) are published in this journal issue. They represent the diversity and richness of the field of Planning in the Public Sector" (Jack Smith); (2) "Futures Planning for Tertiary Education: Curricula for the 21st Century: The…

  18. Promoting Quality through Leadership. General Session Presentations at the Annual Forum of the Association for Institutional Research (28th, Phoenix, Arizona, May 15-18, 1988).

    ERIC Educational Resources Information Center

    Association for Institutional Research.

    Information from the 1988 annual forum of the Association for Institutional Research (AIR) is presented. The focus is on interests, roles, and responsibilities of AIR members. Speakers focus on the theme of promoting quality through leadership, looking at the important role of managerial leadership in the development, implementation, and…

  19. Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (36th, Anaheim, California, 2013). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2013-01-01

    For the thirty-sixth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the annual AECT Convention in Anaheim, California. The Proceedings of AECT's Convention are published in two…

  20. Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (36th, Anaheim, California, 2013). Volume 2

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2013-01-01

    For the thirty-sixth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the annual AECT Convention in Anaheim, California. The Proceedings of AECT's Convention are published in two…

  1. Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (35th, Louisville, Kentucky, 2012). Volume 2

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2012-01-01

    For the thirty-fifth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the national AECT Convention in Louisville, Kentucky. The Proceedings of AECT's Convention are published in…

  2. International Federation of Library Associations Annual Conference Papers. General Research Libraries Division: University Libraries Section (47th, Leipzig, East Germany, August 17-22, 1981).

    ERIC Educational Resources Information Center

    Loveday, Anthony J.; And Others

    This set of papers presented to the General Research Libraries Division, University Libraries Section, of the International Federation of Library Associations during its 47th annual conference (1981) includes: "SCONUL (Standing Conference of National and University Libraries) and British University Library Standards: Some Observations on the Role…

  3. Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (37th, Jacksonville, Florida, 2014). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2014-01-01

    For the thirty-seventh year, the Research and Theory Division and the Division of Instructional Design of the Association for Educational Communications and Technology (AECT) sponsored the publication of these Proceedings. Papers published in this volume were presented at the annual AECT Convention in Jacksonville, Florida. This year's Proceedings…

  4. Planning for Quality. Papers presented at the Annual Meeting of the North East Association for Institutional Research (8th, Princeton, New Jersey, November 5-7, 1981).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    The proceedings of the annual conference of the North East Association for Institutional Research, whose theme was "Planning for Quality," are presented. The 26 papers were divided into the following topics: admissions, assessment, enrollment, faculty and staff, outcomes, planning, programs and retention, the environment, and the field of…

  5. Preservation of Digital Information. Proceedings of the Membership Meeting of the Association of Research Libraries (131st, Washington, DC, October 15-17, 1997).

    ERIC Educational Resources Information Center

    Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

    The 131st meeting of the Association of Research Libraries (ARL) focused on preservation of digital information. The ARL Preservation Committee convened three panels of experts to highlight major issues raised by the archiving of digital resources, and to encourage discussion about options for operating models and criteria for digital archives.…

  6. Proceedings of the Anniversary Meeting (25th, Toronto, December 28-29, 1972). Industrial Relations Research Association Series. Index of IRRA Publications 1966-1972.

    ERIC Educational Resources Information Center

    Somers, Gerald G., Ed.

    Papers presented at the 25th meeting of the Industrial Relations Research Association (IRAA) covered issues that are central to industrial relations in North America. Papers and discussions dealt with these major issues: (1) Prices and Income Policy: Comparative Aspects, (2) Dispute Settlement in the Public Sector, (3) Manpower Policies in Canada…

  7. National Perspectives for ARL Libraries. Minutes of the Semi-Annual Meeting of the Association of Research Libraries (86th, Houston, Texas, May 8-9, 1975).

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC.

    The focus of this Association of Research Libraries meeting was the process of scholarly communication--its costs, complexity and justification. Three speakers made first day presentations. Edward Booher reported on a study of the production and dissemination of scholarly work. He advocated the collaborative efforts of libraries and publishers.…

  8. Assessment: Fad or Fact of Life? Proceedings of the North East Association for Institutional Research Annual Conference (14th, Rochester, New York, October 25-27, 1987).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    Assessment in higher education is addressed in these proceedings of the 1987 conference of the North East Association for Institutional Research. Papers and authors include: "Assessing the Status of Assessment" (Peter T. Ewell); "Has the Middle Class Been Pressured the Most? Multivariate Analysis of Parental Contributions to Higher Education"…

  9. The University as an Open System. Proceedings of the Annual Forum of European Association for Institutional Research (5th, Maastricht, The Netherlands, August 17-19, 1983).

    ERIC Educational Resources Information Center

    Belanger, Charles H., Ed.

    The university as an open system is addressed in 13 papers and 12 abstracts of papers from the 1983 forum of the European Association for Institutional Research. Topics are as follows: program review, analysis of faculty outcomes and characteristics, manpower planning in Dutch universities, adult education in the United Kingdom, outside funding,…

  10. Consortial Leadership: Cooperation in a Competitive Environment. Proceedings of the Meeting of the Association of Research Libraries (130th, Albuquerque, NM, May 14-16, 1997).

    ERIC Educational Resources Information Center

    Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

    The program of the 130th meeting of the Association of Research Libraries (ARL) explored the leadership challenges posed by the juxtapositions of cooperation and competing priorities in a consortial environment. Following an opening and welcome (Gloria Werner, ARL Presiding President), and a Keynote Address, "Defining Successful Leadership" (David…

  11. Leading the Agile Organization. Proceedings of the Annual Meeting of the Association of Research Libraries (128th, Vancouver, BC, May 15-17, 1996).

    ERIC Educational Resources Information Center

    Barrett, Jaia, Ed.; Rounds, Laura, Ed.; Sabnis, Shona, Ed.; Wetzel, Karen A., Ed.

    The program of the 128th meeting of the Association of Research Libraries (ARL) is designed around the notion of examining rapid changes taking place in individual institutions and becoming agile enough to adapt, to manage change, and to learn how to effectively lead libraries through these turbulent periods. The program is divided into three main…

  12. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (28th, Orlando, Florida, 2005). Volume 2

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2005-01-01

    For the twenty-eighth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Orlando, Florida. The Proceedings of AECT's Convention are published in two…

  13. ARL Statistics, 1998-99: A Compilation of Statistics from the One Hundred and Twenty-One Members of the Association of Research Libraries.

    ERIC Educational Resources Information Center

    Kyrillidou, Martha, Comp.; O'Connor, Michael, Comp.

    "ARL Statistics 1998-99" is the latest in a series of annual publications that describe collections, staffing, expenditures, and service activities for the 121 member libraries of the Association of Research Libraries (ARL). The first section of the report includes several illustrative charts and discusses service trends; the decline of ownership,…

  14. ARL Statistics, 1997-98: A Compilation of Statistics from the One Hundred and Twenty-Two Members of the Association of Research Libraries.

    ERIC Educational Resources Information Center

    Kyrillidou, Martha, Comp.; Green, Jonathan, Comp.; Blixrud, Julia C., Comp.

    "ARL Statistics 1997-98" is part of a series of annual publications that describe collections, staffing, expenditures, and service activities for the 122 member libraries of the Association of Research Libraries (ARL). The first section of the report includes several illustrative charts and discusses service trends (1991-1998); the decline of…

  15. The Leadership Role in Library Fund Raising. Minutes of the Membership Meeting of the Association of Research Libraries (120th, Charleston, South Carolina, May 13-15, 1992).

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC.

    The "Leadership Role in Library Fund Raising" was selected as the program theme for the 120th meeting of the Association of Research Libraries (ARL) to call attention to the changing scene of fund raising in higher education. Session 1 set the stage with an overview of the leadership role of library fund raising in the context of the institution…

  16. Literacy Is Transformative. The Thirty-Fifth Yearbook A Doubled Peer Reviewed Publication of the Association of Literacy Educators and Researchers

    ERIC Educational Resources Information Center

    Szabo, Susan, Ed.; Martin, Linda, Ed.; Haas, Leslie, Ed.; Garza-Garcia, Lizabeth, Ed.

    2013-01-01

    For their 56th annual meeting, the Association of Educators and Researchers (ALER) met in Grand Rapids, Michigan at the Amway Grand Hotel. This year's conference theme was Literacy Is Transformative, which was also used as the title for this year's Yearbook, Volume 35. Included are double-peer reviewed papers, the presidential address,…

  17. 1980: Prologue to the Future. Minutes of the Meeting of the Association of Research Libraries (96th, Salt Lake City, Utah, May 15-16, 1980).

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC.

    This report on the proceedings of the 1980 meeting of the Association of Research Libraries (ARL) contains the following papers: "On the Need for a New Energy Consciousness," by James L. Clayton; "Video: Information Technology of the 80's," by Kenneth Winslow; "Linking Bibliographic Utilities," by Donald A. Smalley; "Preservation," by Pamela W.…

  18. The Presidential Address to the Association for Career and Technical Education Research: Using Standards to Reform Teacher Preparation in Career and Technical Education--A Successful Reformation

    ERIC Educational Resources Information Center

    Whittington, M. Susie

    2005-01-01

    This article presents the presidential address at the annual conference of the Association for Career and Technical Education Research by M. Susie Whittington, ACTER President 2005. The purpose of the presidential address is to examine a current issue facing the profession, and pose challenges to the membership in the context of that issue. In her…

  19. The Response of the Institution to External Forces: Proactive or Reactive? Conference Proceedings of the Southern Association for Institutional Research (Virginia Beach, Virginia, October 30-November 1, 1985).

    ERIC Educational Resources Information Center

    Orahood, Mary Alyce, Ed.

    The proceedings of the 1985 conference of the Southern Association for Institutional Research (SAIR) is presented. The focus was preparing colleges to anticipate and respond to the demand of accrediting bodies, federal agencies, and state legislatures. Contents include: a conference agenda; a keynote address, summaries of pre-conference workshops,…

  20. Toward Self Sufficiency: Social Issues in the Nineties. Proceedings of the National Association for Welfare Research and Statistics (33rd, Scottsdale, Arizona, August 7-11, 1993).

    ERIC Educational Resources Information Center

    National Association for Welfare Research and Statistics, Olympia, WA.

    The presentations compiled in these proceedings on welfare and self-sufficiency reflect much of the current research in areas of housing, health, employment and training, welfare and reform, nutrition, child support, child care, and youth. The first section provides information on the conference and on the National Association for Welfare Research…

  1. Proceedings of the Annual Meeting of the Mid-South Educational Research Association (25th, Tuscaloosa, Alabama, November 6-8, 1996).

    ERIC Educational Resources Information Center

    Petry, John R., Ed.; McCree, Herbert L., Ed.

    This volume contains abstracts of the more than 250 discussion papers, symposia, displays, and training sessions presented at the Mid-South Educational Research Association (MSERA) 1996 annual meeting. Papers deal with elementary, secondary, and higher education, and cover a broad spectrum of educational issues. Although many papers focus on the…

  2. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (27th, Chicago, Illinois, 2004). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.; Crawford, Margaret, Ed.

    2004-01-01

    For the twenty-seventh year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Chicago, Illinois. The Proceedings of AECT's Convention are published in two…

  3. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (30th, Anaheim, California, 2007). Volume 2

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2007-01-01

    For the thirtieth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Anaheim, California. The Proceedings of AECT's Convention are published in two…

  4. Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (32nd, Louisville, KY, 2009). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2009-01-01

    For the thirty-second year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the national AECT Convention in Louisville, Kentucky. The Proceedings of AECT's Convention are published in two…

  5. Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (33rd, Anaheim, California, 2010). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2010-01-01

    For the thirty-third year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the national AECT Convention in Anaheim, California. The Proceedings of AECT's Convention are published in two…

  6. Annual Proceedings of Selected Research and Development Papers Presented at the National Convention of the Association for Educational Communications and Technology (30th, Anaheim, California, 2007). Volume 1

    ERIC Educational Resources Information Center

    Simonson, Michael, Ed.

    2007-01-01

    For the thirtieth year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) is sponsoring the publication of these Proceedings. Papers published in this volume were presented at the National AECT Convention in Anaheim, California. The Proceedings of AECT's Convention are published in two…

  7. COPD exacerbations associated with the modified Medical Research Council scale and COPD assessment test among Humana Medicare members

    PubMed Central

    Pasquale, Margaret K; Xu, Yihua; Baker, Christine L; Zou, Kelly H; Teeter, John G; Renda, Andrew M; Davis, Cralen C; Lee, Theodore C; Bobula, Joel

    2016-01-01

    Background The Global initiative for chronic Obstructive Lung Disease guidelines recommend assessment of COPD severity, which includes symptomatology using the modified Medical Research Council (mMRC) or COPD assessment test (CAT) score in addition to the degree of airflow obstruction and exacerbation history. While there is great interest in incorporating symptomatology, little is known about how patient reported symptoms are associated with future exacerbations and exacerbation-related costs. Methods The mMRC and CAT were mailed to a randomly selected sample of 4,000 Medicare members aged >40 years, diagnosed with COPD (≥2 encounters with International Classification of Dis eases-9th Edition Clinical Modification: 491.xx, 492.xx, 496.xx, ≥30 days apart). The exacerbations and exacerbation-related costs were collected from claims data during 365-day post-survey after exclusion of members lost to follow-up or with cancer, organ transplant, or pregnancy. A logistic regression model estimated the predictive value of exacerbation history and symptomatology on exacerbations during follow-up, and a generalized linear model with log link and gamma distribution estimated the predictive value of exacerbation history and symptomatology on exacerbation-related costs. Results Among a total of 1,159 members who returned the survey, a 66% (765) completion rate was observed. Mean (standard deviation) age among survey completers was 72.0 (8.3), 53.7% female and 91.2% white. Odds ratios for having post-index exacerbations were 3.06, 4.55, and 16.28 times for members with 1, 2, and ≥3 pre-index exacerbations, respectively, relative to members with 0 pre-index exacerbations (P<0.001 for all). The odds ratio for high vs low symptoms using CAT was 2.51 (P<0.001). Similarly, exacerbation-related costs were 73% higher with each incremental pre-index exacerbation, and over four fold higher for high-vs low-symptom patients using CAT (each P<0.001). The symptoms using mMRC were not

  8. Research in Science Education, Volume 5. Proceedings of the Annual Conference of the Australian Science Education Research Association (6th, Flinders University, Bedford Park, South Australia, May 19-21, 1975).

    ERIC Educational Resources Information Center

    Lucas, A. M., Ed.; Power, Colin, N., Ed.

    This volume contains papers presented at the sixth Annual Conference of the Australian Science Education Research Association (ASERA) held at Flinders University in May, 1975. Paper topics include: pupil learning and classroom climate, teacher structuring behavior, the Australian Science Education Project (ASEP), cognitive preference and…

  9. Proceedings of Selected Research Paper Presentations at the 1980 Convention of the Association for Educational Communications and Technology and Sponsored by the Research and Theory Division (Denver, CO, April 21-24, 1980).

    ERIC Educational Resources Information Center

    Simonson, Michael R., Ed.; Rohner, Daniel, Ed.

    The 31 papers in this collection represent approximately 35 percent of the manuscripts which were submitted for consideration to the Research and Theory Division of the Association for Educational Communications and Technology (AECT) for presentation at the 1980 AECT convention. All papers were subjected to a blind reviewing process and the ones…

  10. Institutional Research and Strategies for Higher Education Issues in the 1980's and Research Exchange Forum. Proceedings of the Annual Meeting of the North Carolina Association for Institutional Research (7th, Raleigh, North Carolina, November 1, 1979) and the Drive-In Conference (Chapel Hill, North Carolina, April 18, 1980).

    ERIC Educational Resources Information Center

    Brown, Charles I., Ed.; Ussery, Robert M., Ed.

    Proceedings of the 1979 conference of the North Carolina Association for Institutional Research and the 1980 Research Search Exchange Drive-In Conference Program, which address the skills needed by institutional researchers to deal with the issues in higher education in the 1980s, are presented. Highlights of the North Carolina association…

  11. Twelve Years of Acoustical Research. American School Band Directors' Association, Research Committee Reports for the 17th Annual Convention, Hot Springs, Arkansas, 1969.

    ERIC Educational Resources Information Center

    American School Band Directors Association, Newark, OH.

    The guide, one in a series of committee reports relating to school band performance, organization, and equipment needs, discusses acoustical problems inherent to the clarinet. The report is presented in five sections. Section I summarizes findings of an American School Band Directors' Association (ASBDA) clarinet testing committee. A major finding…

  12. Annual Research Review: Functional Somatic Symptoms and Associated Anxiety and Depression--Developmental Psychopathology in Pediatric Practice

    ERIC Educational Resources Information Center

    Campo, John V.

    2012-01-01

    Background: Medically unexplained physical symptoms, commonly referred to as functional somatic symptoms (FSS), are common in pediatric medical settings and associated with suffering, impairment, and medical help seeking. The association of pediatric FSS with anxiety and depressive symptoms and disorders across the life span is reviewed.Method:…

  13. Ethical Principles Associated with the Publication of Research in ASHA's Scholarly Journals: Importance and Adequacy of Coverage

    ERIC Educational Resources Information Center

    Ingham, Janis C.; Minifie, Fred D.; Horner, Jennifer; Robey, Randall R.; Lansing, Charissa; McCartney, James H.; Slater, Sarah C.; Moss, Sharon E.

    2011-01-01

    Purpose: The purpose of this 2-part study was to determine the importance of specific topics relating to publication ethics and adequacy of the American Speech-Language-Hearing Association's (ASHA's) policies regarding these topics. Method: A 56-item Web-based survey was sent to (a) ASHA journal editors, associate editors, and members of the…

  14. 78 FR 79498 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Open-IX Association

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Association Notice is hereby given that, on December 3, 2013, pursuant to Section 6(a) of the National... Association (``Open-IX'') has filed written notifications simultaneously with the Attorney General and the... and principal place of business of the standards development organization is: Open-IX...

  15. Institutional Research in a Changing Society. Proceedings of the Annual Conference of the North East Association for Institutional Research (18th, Cambridge, Massachusetts, November 16-19, 1991).

    ERIC Educational Resources Information Center

    Bauer, Karen, Ed.

    This document contains formal papers, keynote speeches and selected panel presentations delivered at a conference that addressed the issues, responsibilities and challenges faced by institutional researchers now and in the future. Papers are as follows: "Attrition and C.I.R.P. Correlates of a Measure of Self-Confidence Regarding Transition into…

  16. Accountability and Institutional Research: Measuring Results. Proceedings of the Annual Conference of the North East Association for Institutional Research (24th, Hartford, Connecticut, November 1-4, 1997).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    This proceedings document is comprised of the 12 papers, panel presentations, and work shares presented at a 1997 conference on institutional research. The papers are: (1) "What Does Accountability in Higher Education Mean to You?" (William R. Dyson, Andrew G. De Rocco, John R. Doyle, and Merle W. Harris); (2) "The University of Delaware…

  17. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology into NASA Programs Associated with the Aeronautics Research Mission Directorate

    NASA Technical Reports Server (NTRS)

    Nguyen, Hung D.; Steele, Gynelle C.

    2015-01-01

    This report is intended to help NASA program and project managers incorporate Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) technologies that have gone through Phase II of the SBIR program into NASA Aeronautics and Mission Directorate (ARMD) programs. Other Government and commercial program managers can also find this information useful.

  18. Institutional Research: Coming of Age. General Session Presentations [at the] Annual Forum [of the] Association for Institutional Research (30th, Louisville, Kentucky, May 13-16, 1990).

    ERIC Educational Resources Information Center

    Endo, Jean J., Ed.

    Synopses of six conference presentations are provided in this pamphlet, dealing with the theme of leadership and professional standards in university settings and the influence of social and technological challenges. In "Leadership and Team Building: Key Ingredients to the Institutional Research Role of the Future," Robert L. Taylor challenges…

  19. The International Social Organisation of Educational Research in Europe: Reviewing the European Educational Research Association as an Example--Facts and Questions

    ERIC Educational Resources Information Center

    Gretler, Armin

    2007-01-01

    Armin Gretler passed away on 6 October 2005. Armin was a founder member of the EERA and served on its Council, representing Switzerland. He was a sociologist and founding director of the Swiss Coordination Centre for Research in Education in 1971. He remained Director until retiring in 1999. Prior to that he had been working as a consultant for…

  20. Propensity Score Techniques and the Assessment of Measured Covariate Balance to Test Causal Associations in Psychological Research

    ERIC Educational Resources Information Center

    Harder, Valerie S.; Stuart, Elizabeth A.; Anthony, James C.

    2010-01-01

    There is considerable interest in using propensity score (PS) statistical techniques to address questions of causal inference in psychological research. Many PS techniques exist, yet few guidelines are available to aid applied researchers in their understanding, use, and evaluation. In this study, the authors give an overview of available…

  1. Association of Research Self-Efficacy with Medical Student Career Interests, Specialization, and Scholarship: A Case Study

    ERIC Educational Resources Information Center

    Bierer, S. Beth; Prayson, Richard A.; Dannefer, Elaine F.

    2015-01-01

    This study used variables proposed in social cognitive career theory (SCCT) to focus the evaluation of a research curriculum at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). Eight cohorts of CCLCM medical students completed a web-based version of the six-scale Clinical Research Appraisal…

  2. Size and characteristics of the biomedical research workforce associated with U.S. National Institutes of Health extramural grants.

    PubMed

    Pool, Lindsay R; Wagner, Robin M; Scott, Lindsey L; RoyChowdhury, Deepshikha; Berhane, Rediet; Wu, Charles; Pearson, Katrina; Sutton, Jennifer A; Schaffer, Walter T

    2016-03-01

    The U.S. National Institutes of Health (NIH) annually invests approximately $22 billion in biomedical research through its extramural grant programs. Since fiscal year (FY) 2010, all persons involved in research during the previous project year have been required to be listed on the annual grant progress report. These new data have enabled the production of the first-ever census of the NIH-funded extramural research workforce. Data were extracted from All Personnel Reports submitted for NIH grants funded in FY 2009, including position title, months of effort, academic degrees obtained, and personal identifiers. Data were de-duplicated to determine a unique person count. Person-years of effort (PYE) on NIH grants were computed. In FY 2009, NIH funded 50,885 grant projects, which created 313,049 full- and part-time positions spanning all job functions involved in biomedical research. These positions were staffed by 247,457 people at 2,604 institutions. These persons devoted 121,465 PYE to NIH grant-supported research. Research project grants each supported 6 full- or part-time positions, on average. Over 20% of positions were occupied by postdoctoral researchers and graduate and undergraduate students. These baseline data were used to project workforce estimates for FYs 2010-2014 and will serve as a foundation for future research.

  3. Size and characteristics of the biomedical research workforce associated with U.S. National Institutes of Health extramural grants.

    PubMed

    Pool, Lindsay R; Wagner, Robin M; Scott, Lindsey L; RoyChowdhury, Deepshikha; Berhane, Rediet; Wu, Charles; Pearson, Katrina; Sutton, Jennifer A; Schaffer, Walter T

    2016-03-01

    The U.S. National Institutes of Health (NIH) annually invests approximately $22 billion in biomedical research through its extramural grant programs. Since fiscal year (FY) 2010, all persons involved in research during the previous project year have been required to be listed on the annual grant progress report. These new data have enabled the production of the first-ever census of the NIH-funded extramural research workforce. Data were extracted from All Personnel Reports submitted for NIH grants funded in FY 2009, including position title, months of effort, academic degrees obtained, and personal identifiers. Data were de-duplicated to determine a unique person count. Person-years of effort (PYE) on NIH grants were computed. In FY 2009, NIH funded 50,885 grant projects, which created 313,049 full- and part-time positions spanning all job functions involved in biomedical research. These positions were staffed by 247,457 people at 2,604 institutions. These persons devoted 121,465 PYE to NIH grant-supported research. Research project grants each supported 6 full- or part-time positions, on average. Over 20% of positions were occupied by postdoctoral researchers and graduate and undergraduate students. These baseline data were used to project workforce estimates for FYs 2010-2014 and will serve as a foundation for future research. PMID:26625903

  4. Does Research on Evaluation Matter? Findings from a Survey of American Evaluation Association Members and Prominent Evaluation Theorists and Scholars

    ERIC Educational Resources Information Center

    Coryn, Chris L. S.; Ozeki, Satoshi; Wilson, Lyssa N.; Greenman, Gregory D., II; Schröter, Daniela C.; Hobson, Kristin A.; Azzam, Tarek; Vo, Anne T.

    2016-01-01

    Research on evaluation theories, methods, and practices has increased considerably in the past decade. Even so, little is known about whether published findings from research on evaluation are read by evaluators and whether such findings influence evaluators' thinking about evaluation or their evaluation practice. To address these questions, and…

  5. Association between co-authorship network and scientific productivity and impact indicators in academic medical research centers: A case study in Iran

    PubMed Central

    Yousefi-Nooraie, Reza; Akbari-Kamrani, Marjan; Hanneman, Robert A; Etemadi, Arash

    2008-01-01

    Background We aimed to examine the co-authorship networks in three successful Iranian academic research centers, in order to find the association between the scientific productivity and impact indicators with network features in a case study. Methods We searched for English articles of the three research centers. We drew co-authorship maps of each center and calculated social network measures. Results The collaboration networks in centers shared many structural features, including a "star-like" pattern of relations. Centers with more successful scientific profile showed denser and more cooperative networks. Key figures in each center were interviewed for their understandings of the reasons for the emergence of these patterns. Conclusion Star shape network structure and dependency on a single big member is a common feature observed in our case study. Scientific output measures correlate with the network structure of research centers. Network analysis seems a useful method to explore the subtle scientific contexts in research organizations. PMID:18796149

  6. Canadian Association of Gastroenterology - Canadian Institutes of Health Research - pharmaceutical partner postdoctoral operating fellowship programme: an outstanding success that continues to excel!

    PubMed

    McKay, Derek M; Daniels, Sandra

    2003-07-01

    The Canadian Association of Gastroenterology (CAG) postdoctoral fellowship programme was initiated in 1992 with the goal of promoting excellence in Canadian gastroenterological research. With backing from multiple pharmaceutical partners and the Canadian Institutes of Health Research, 87 fellows were funded over the next ten years for a total investment of $8,730,101. Between 1992 and 2000, fellows authored 247 articles; 176 being original research articles, 31 (17.5%) of which appeared in journals with impact factors of greater than 10. As testament to the program's success in developing young scientists, 31 former fellows (36%) have progressed to faculty positions. The fellowship programme continues to be an outstanding success and the flagship of CAG research activities.

  7. Electronic tissue compensation achieved with both dynamic and static multileaf collimator in eclipse treatment planning system for Clinac 6 EX and 2100 CD Varian linear accelerators: Feasibility and dosimetric study

    PubMed Central

    Kinhikar, Rajesh A.; Sharma, Pramod K.; Patkar, Sachin; Tambe, Chandrashekhar M.; Deshpande, Deepak D.

    2007-01-01

    Dynamic multileaf collimator (DMLC) and static multileaf collimator (SMLC), along with three-dimensional treatment planning system (3-D TPS), open the possibility of tissue compensation. A method using electronic tissue compensator (ETC) has been implemented in Eclipse 3-D TPS (V 7.3, Varian Medical Systems, Palo Alto, USA) at our center. The ETC was tested for head and neck conformal radiotherapy planning. The purpose of this study was to verify the feasibility of DMLC and SMLC in head and neck field irradiation for delivering homogeneous dose in the midplane at a pre-defined depth. In addition, emphasis was given to the dosimetric aspects in commissioning ETC in Eclipse. A Head and Neck Phantom (The Phantom Laboratory, USA) was used for the dosimetric verification. Planning was carried out for both DMLC and SMLC ETC plans. The dose calculated at central axis by eclipse with DMLC and SMLC was noted. This was compared with the doses measured on machine with ion chamber and thermoluminescence dosimetry (TLD). The calculated isodose curves and profiles were compared with the measured ones. The dose profiles along the two major axes from Eclipse were also compared with the profiles obtained from Amorphous Silicon (AS500) Electronic portal imaging device (EPID) on Clinac 6 EX machine. In uniform dose regions, measured dose values agreed with the calculated doses within 3%. Agreement between calculated and measured isodoses in the dose gradient zone was within 3 mm. The isodose curves and the profiles were found to be in good agreement with the measured curves and profiles. The measured and the calculated dose profiles along the two major axes were flat for both DMLC and SMLC. The dosimetric verification of ETC for both the linacs demonstrated the feasibility and the accuracy of the ETC treatment modality for achieving uniform dose distributions. Therefore, ETC can be used as a tool in head and neck treatment planning optimization for improved dose uniformity. PMID

  8. A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.

    PubMed

    Tang, Weihong; Teichert, Martina; Chasman, Daniel I; Heit, John A; Morange, Pierre-Emmanuel; Li, Guo; Pankratz, Nathan; Leebeek, Frank W; Paré, Guillaume; de Andrade, Mariza; Tzourio, Christophe; Psaty, Bruce M; Basu, Saonli; Ruiter, Rikje; Rose, Lynda; Armasu, Sebastian M; Lumley, Thomas; Heckbert, Susan R; Uitterlinden, André G; Lathrop, Mark; Rice, Kenneth M; Cushman, Mary; Hofman, Albert; Lambert, Jean-Charles; Glazer, Nicole L; Pankow, James S; Witteman, Jacqueline C; Amouyel, Philippe; Bis, Joshua C; Bovill, Edwin G; Kong, Xiaoxiao; Tracy, Russell P; Boerwinkle, Eric; Rotter, Jerome I; Trégouët, David-Alexandre; Loth, Daan W; Stricker, Bruno H Ch; Ridker, Paul M; Folsom, Aaron R; Smith, Nicholas L

    2013-07-01

    Venous thromboembolism (VTE) is a common, heritable disease resulting in high rates of hospitalization and mortality. Yet few associations between VTE and genetic variants, all in the coagulation pathway, have been established. To identify additional genetic determinants of VTE, we conducted a two-stage genome-wide association study (GWAS) among individuals of European ancestry in the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) VTE consortium. The discovery GWAS comprised 1,618 incident VTE cases out of 44,499 participants from six community-based studies. Genotypes for genome-wide single-nucleotide polymorphisms (SNPs) were imputed to approximately 2.5 million SNPs in HapMap and association with VTE assessed using study-design appropriate regression methods. Meta-analysis of these results identified two known loci, in F5 and ABO. Top 1,047 tag SNPs (P ≤ 0.0016) from the discovery GWAS were tested for association in an additional 3,231 cases and 3,536 controls from three case-control studies. In the combined data from these two stages, additional genome-wide significant associations were observed on 4q35 at F11 (top SNP rs4253399, intronic to F11) and on 4q28 at FGG (rs6536024, 9.7 kb from FGG; P < 5.0 × 10(-13) for both). The associations at the FGG locus were not completely explained by previously reported variants. Loci at or near SUSD1 and OTUD7A showed borderline yet novel associations (P < 5.0 × 10(-6) ) and constitute new candidate genes. In conclusion, this large GWAS replicated key genetic associations in F5 and ABO, and confirmed the importance of F11 and FGG loci for VTE. Future studies are warranted to better characterize the associations with F11 and FGG and to replicate the new candidate associations.

  9. Occupational exposure of healthcare and research staff to static magnetic stray fields from 1.5–7 Tesla MRI scanners is associated with reporting of transient symptoms

    PubMed Central

    Schaap, Kristel; Christopher-de Vries, Yvette; Mason, Catherine K; de Vocht, Frank; Portengen, Lützen; Kromhout, Hans

    2014-01-01

    Objectives Limited data is available about incidence of acute transient symptoms associated with occupational exposure to static magnetic stray fields from MRI scanners. We aimed to assess the incidence of these symptoms among healthcare and research staff working with MRI scanners, and their association with static magnetic field exposure. Methods We performed an observational study among 361 employees of 14 clinical and research MRI facilities in The Netherlands. Each participant completed a diary during one or more work shifts inside and/or outside the MRI facility, reporting work activities and symptoms (from a list of potentially MRI-related symptoms, complemented with unrelated symptoms) experienced during a working day. We analysed 633 diaries. Exposure categories were defined by strength and type of MRI scanner, using non-MRI shifts as the reference category for statistical analysis. Non-MRI shifts originated from MRI staff who also participated on MRI days, as well as CT radiographers who never worked with MRI. Results Varying per exposure category, symptoms were reported during 16–39% of the MRI work shifts. We observed a positive association between scanner strength and reported symptoms among healthcare and research staff working with closed-bore MRI scanners of 1.5 Tesla (T) and higher (1.5 T OR=1.88; 3.0 T OR=2.14; 7.0 T OR=4.17). This finding was mainly driven by reporting of vertigo and metallic taste. Conclusions The results suggest an exposure-response association between exposure to strong static magnetic fields (and associated motion-induced time-varying magnetic fields) and reporting of transient symptoms on the same day of exposure. Trial registration number 11-032/C PMID:24714654

  10. An Interview with the President-Elect of the American Association for Clinical Chemistry - Office of Cancer Clinical Proteomics Research

    Cancer.gov

    The AACC has a number of key goals as it moves into 2011 including: developing ways to continue working with industry within the new AdvaMed guidelines; developing ways in which the AACC can collaborate more with other professional medical associations; increasing the recognition of translational science at our annual meeting; and continuing our global outreach

  11. [Papers Presented at the American Medical Association's Air Pollution Medical Research Conference (New Orleans, Louisiana, October 5-7, 1970).

    ERIC Educational Resources Information Center

    American Medical Association, Chicago, IL.

    This is a collection of twenty speeches presented at the American Medical Association's Air Pollution Medical Conference, October 5-7, 1970. Speeches included: Air Pollution Control: The Physician's Role; Air Pollution Problems in Nuclear Power Development; Airway Resistance and Collateral Ventilation; Asbestos Air Pollution in Urban Areas;…

  12. Associations between personal exposures to VOCs and alterations in cardiovascular physiology: Detroit Exposure and Aerosol Research Study (DEARS) - presentation

    EPA Science Inventory

    Introduction: An adult cohort consisting of 63 participants engaged in the US EPA’s recent Detroit Exposure and Aerosol Research Study (DEARS) and a University of Michigan cardiovascular sub-study conducted during summer and winter periods over 3 years between 2004 and 2007...

  13. Current Models of Digital Scholarly Communication: Results of an Investigation Conducted by Ithaka for the Association of Research Libraries

    ERIC Educational Resources Information Center

    Maron, Nancy L.; Smith, K. Kirby

    2008-01-01

    As electronic resources for scholarship proliferate, more and more scholars turn to their computers rather than to print sources to conduct their research. The decentralized distribution of these new model works can make it difficult to fully appreciate their scope and number, even for university librarians tasked with knowing about valuable…

  14. Finances top challenge charts for association members. Exclusive findings from annual Medical Practice Today: what members have to say research.

    PubMed

    Grimshaw, Heather

    2012-07-01

    Learn which issues--out of a list of 52--are most applicable and intense foryou and your colleagues in this year's "Medical Practice Today: What members have to say" research. To help you find solutions for those issues, we have paired the top 10 challenges (identified by our applicability-weighted index) with MGMA-ACMPE resources on pages 52 and 53.

  15. Trade and Industrial Education Research Committee. Proceedings of the Carrousel Session, American Vocational Association (Dallas, Texas, December 8, 1986).

    ERIC Educational Resources Information Center

    Roth, Gene L., Ed.

    These proceedings contain the texts of five research reports that were presented at a conference dealing with trade and industrial education. The following papers are included: "A Survey of Teacher Attitudes and Beliefs Related to the Use of Microcomputers in Vocational Education," by Steve Chi-Yin Yuen; "Retraining for Robotics and Other Forms of…

  16. The Associations between Language Aptitude and Second Language Grammar Acquisition: A Meta-Analytic Review of Five Decades of Research

    ERIC Educational Resources Information Center

    Li, Shaofeng

    2015-01-01

    This study reports a meta-analysis that synthesizes the empirical research on the role of language aptitude in second language grammar acquisition. A total of 33 study reports were identified including 17 predictive studies that investigated the correlations between aptitude and ultimate L2 attainment and 16 interactional studies that examined the…

  17. Risky Assessments: Participant Suicidality and Distress Associated with Research Assessments in a Treatment Study of Suicidal Behavior

    ERIC Educational Resources Information Center

    Reynolds, Sarah K.; Lindenboim, Noam; Comtois, Katherine Anne; Murray, Angela; Linehan, Marsha M.

    2006-01-01

    The purpose of this study was to examine patterns of self-reported suicidality and distress during research assessments in a sample of 63 women meeting criteria for borderline personality disorder and current and chronic suicidality. The risk management protocol we used during the two-year study period (University of Washington Risk Assessment…

  18. Associations between Personal Exposures to VOCs and Alterations in Cardiovascular Physiology: Detroit Exposure and Aerosol Research Study (DEARS)

    EPA Science Inventory

    Background: An adult cohort consisting of 63 participants engaged in the US EPA’s recent Detroit Exposure and Aerosol Research Study (DEARS) and a University of Michigan cardiovascular sub-study conducted during summer and winter periods over 3 years between 2004 and 2007 (5 seas...

  19. PERSONAL, RESIDENTIAL AND CENTRAL SITE PM MASS CONCENTRATIONS ASSOCIATED WITH THE DETROIT EXPOSURE AND AEROSOL RESEARCH STUDY ( DEARS )

    EPA Science Inventory

    The DEARS is a three year field monitoring study being performed by the US EPA's National Exposure Research Laboratory in the Detroit, Michigan area. Two years of monitoring have been completed and data from the first year of the study is currently being analyzed. This report ...

  20. Is Dyslexia Necessarily Associated with Negative Feelings of Self-Worth? A Review and Implications for Future Research

    ERIC Educational Resources Information Center

    Burden, Robert

    2008-01-01

    This paper will provide an overview of research in the past 20 years into the relationship between dyslexia and various aspects of self-perception, including self-concept, self-esteem, self-efficacy and locus of control. Problems are identified relating to the measurement of some of the most widely used constructs, as is the need for more precise…

  1. The utility of web mining for epidemiological research: studying the association between parity and cancer risk [Web Mining for Epidemiological Research. Assessing its Utility in Exploring the Association Between Parity and Cancer Risk

    DOE PAGES

    Tourassi, Georgia; Yoon, Hong-Jun; Xu, Songhua; Han, Xuesong

    2015-11-27

    Background: The World Wide Web has emerged as a powerful data source for epidemiological studies related to infectious disease surveillance. However, its potential for cancer-related epidemiological discoveries is largely unexplored. Methods: Using advanced web crawling and tailored information extraction procedures we automatically collected and analyzed the text content of 79,394 online obituary articles published between 1998 and 2014. The collected data included 51,911 cancer (27,330 breast; 9,470 lung; 6,496 pancreatic; 6,342 ovarian; 2,273 colon) and 27,483 non-cancer cases. With the derived information, we replicated a case-control study design to investigate the association between parity and cancer risk. Age-adjusted odds ratiosmore » (ORs) with 95% confidence intervals (CIs) were calculated for each cancer type and compared to those reported in large-scale epidemiological studies. Results: Parity was found to be associated with a significantly reduced risk of breast cancer (OR=0.78, 95% CI = 0.75 to 0.82), pancreatic cancer (OR=0.78, 95% CI = 0.72 to 0.83), colon cancer (OR=0.67, 95% CI = 0.60 to 0.74), and ovarian cancer (OR=0.58, 95% CI = 0.54 to 0.62). Marginal association was found for lung cancer prevalence (OR=0.87, 95% CI = 0.81 to 0.92). The linear trend between multi-parity and reduced cancer risk was dramatically more pronounced for breast and ovarian cancer than the other cancers included in the analysis. Conclusion: This large web-mining study on parity and cancer risk produced findings very similar to those reported with traditional observational studies. It may be used as a promising strategy to generate study hypotheses for guiding and prioritizing future epidemiological studies.« less

  2. The utility of web mining for epidemiological research: studying the association between parity and cancer risk [Web Mining for Epidemiological Research. Assessing its Utility in Exploring the Association Between Parity and Cancer Risk

    SciTech Connect

    Tourassi, Georgia; Yoon, Hong-Jun; Xu, Songhua; Han, Xuesong

    2015-11-27

    Background: The World Wide Web has emerged as a powerful data source for epidemiological studies related to infectious disease surveillance. However, its potential for cancer-related epidemiological discoveries is largely unexplored. Methods: Using advanced web crawling and tailored information extraction procedures we automatically collected and analyzed the text content of 79,394 online obituary articles published between 1998 and 2014. The collected data included 51,911 cancer (27,330 breast; 9,470 lung; 6,496 pancreatic; 6,342 ovarian; 2,273 colon) and 27,483 non-cancer cases. With the derived information, we replicated a case-control study design to investigate the association between parity and cancer risk. Age-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for each cancer type and compared to those reported in large-scale epidemiological studies. Results: Parity was found to be associated with a significantly reduced risk of breast cancer (OR=0.78, 95% CI = 0.75 to 0.82), pancreatic cancer (OR=0.78, 95% CI = 0.72 to 0.83), colon cancer (OR=0.67, 95% CI = 0.60 to 0.74), and ovarian cancer (OR=0.58, 95% CI = 0.54 to 0.62). Marginal association was found for lung cancer prevalence (OR=0.87, 95% CI = 0.81 to 0.92). The linear trend between multi-parity and reduced cancer risk was dramatically more pronounced for breast and ovarian cancer than the other cancers included in the analysis. Conclusion: This large web-mining study on parity and cancer risk produced findings very similar to those reported with traditional observational studies. It may be used as a promising strategy to generate study hypotheses for guiding and prioritizing future epidemiological studies.

  3. Tectonic evolution of greenstone-Gneiss association in Dharwar Craton, South India: Problems and perspectives for future research

    NASA Technical Reports Server (NTRS)

    Rao, Y. J. B.

    1986-01-01

    The two fold stratigraphic subdivision of the Archean-Proterozoic greenstone-gneiss association of Dharwar craton into an older Sargur group (older than 2.9 Ga.) and a younger Dharwar Supergroup serves as an a priori stratigraphic model. The concordant greenstone (schist)-gneiss (Peninsular gneiss) relationships, ambiguities in stratigraphic correlations of the schist belts assigned to Sargur group and difficulties in deciphering the older gneiss units can be best appreciated if the Sargur group be regarded as a trimodal association of: (1) ultrabasic-mafic metavolcanics (including komatiites), (2) clastic and nonclastic metasediments and paragneisses and (3) mainly tonalite/trondhemite gneisses and migmatites of diverse ages which could be as old as c. 3.4 ga. or even older. The extensive occurrence of this greenstone-gneiss complex is evident from recent mapping in many areas of central and southern Karnataka State.

  4. Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology.

    PubMed

    Brandon, Thomas H; Goniewicz, Maciej L; Hanna, Nasser H; Hatsukami, Dorothy K; Herbst, Roy S; Hobin, Jennifer A; Ostroff, Jamie S; Shields, Peter G; Toll, Benjamin A; Tyne, Courtney A; Viswanath, Kasisomayajula; Warren, Graham W

    2015-03-10

    Combustible tobacco use remains the number-one preventable cause of disease, disability, and death in the United States. Electronic nicotine delivery systems (ENDS), which include electronic cigarettes, are devices capable of delivering nicotine in an aerosolized form. ENDS use by both adults and youth has increased rapidly, and some have advocated these products could serve as harm-reduction devices and smoking cessation aids. ENDS may be beneficial if they reduce smoking rates or prevent or reduce the known adverse health effects of smoking. However, ENDS may also be harmful, particularly to youth, if they increase the likelihood that nonsmokers or former smokers will use combustible tobacco products or if they discourage smokers from quitting. The American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) recognize the potential ENDS have to alter patterns of tobacco use and affect the health of the public; however, definitive data are lacking. The AACR and ASCO recommend additional research on these devices, including assessing the health impacts of ENDS, understanding patterns of ENDS use, and determining what role ENDS have in cessation. Key policy recommendations include supporting federal, state, and local regulation of ENDS; requiring manufacturers to register with the US Food and Drug Administration and report all product ingredients, requiring childproof caps on ENDS liquids, and including warning labels on products and their advertisements; prohibiting youth-oriented marketing and sales; prohibiting child-friendly ENDS flavors; and prohibiting ENDS use in places where cigarette smoking is prohibited. This policy statement was developed by a joint writing group composed of members from the Tobacco and Cancer Subcommittee of the American Association for Cancer Research (AACR) Science Policy and Government Affairs (SPGA) Committee and American Society of Clinical Oncology (ASCO) Tobacco Cessation and Control

  5. Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology.

    PubMed

    Brandon, Thomas H; Goniewicz, Maciej L; Hanna, Nasser H; Hatsukami, Dorothy K; Herbst, Roy S; Hobin, Jennifer A; Ostroff, Jamie S; Shields, Peter G; Toll, Benjamin A; Tyne, Courtney A; Viswanath, Kasisomayajula; Warren, Graham W

    2015-03-10

    Combustible tobacco use remains the number-one preventable cause of disease, disability, and death in the United States. Electronic nicotine delivery systems (ENDS), which include electronic cigarettes, are devices capable of delivering nicotine in an aerosolized form. ENDS use by both adults and youth has increased rapidly, and some have advocated these products could serve as harm-reduction devices and smoking cessation aids. ENDS may be beneficial if they reduce smoking rates or prevent or reduce the known adverse health effects of smoking. However, ENDS may also be harmful, particularly to youth, if they increase the likelihood that nonsmokers or former smokers will use combustible tobacco products or if they discourage smokers from quitting. The American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) recognize the potential ENDS have to alter patterns of tobacco use and affect the health of the public; however, definitive data are lacking. The AACR and ASCO recommend additional research on these devices, including assessing the health impacts of ENDS, understanding patterns of ENDS use, and determining what role ENDS have in cessation. Key policy recommendations include supporting federal, state, and local regulation of ENDS; requiring manufacturers to register with the US Food and Drug Administration and report all product ingredients, requiring childproof caps on ENDS liquids, and including warning labels on products and their advertisements; prohibiting youth-oriented marketing and sales; prohibiting child-friendly ENDS flavors; and prohibiting ENDS use in places where cigarette smoking is prohibited. This policy statement was developed by a joint writing group composed of members from the Tobacco and Cancer Subcommittee of the American Association for Cancer Research (AACR) Science Policy and Government Affairs (SPGA) Committee and American Society of Clinical Oncology (ASCO) Tobacco Cessation and Control

  6. Active Learning in Research Methods Classes Is Associated with Higher Knowledge and Confidence, Though not Evaluations or Satisfaction.

    PubMed

    Allen, Peter J; Baughman, Frank D

    2016-01-01

    Research methods and statistics are regarded as difficult subjects to teach, fueling investigations into techniques that increase student engagement. Students enjoy active learning opportunities like hands-on demonstrations, authentic research participation, and working with real data. However, enhanced enjoyment does not always correspond with enhanced learning and performance. In this study, we developed a workshop activity in which students participated in a computer-based experiment and used class-generated data to run a range of statistical procedures. To enable evaluation, we developed a parallel, didactic/canned workshop, which was identical to the activity-based version, except that students were told about the experiment and used a pre-existing/canned dataset to perform their analyses. Tutorial groups were randomized to one of the two workshop versions, and 39 students completed a post-workshop evaluation questionnaire. A series of generalized linear mixed models suggested that, compared to the students in the didactic/canned condition, students exposed to the activity-based workshop displayed significantly greater knowledge of the methodological and statistical issues addressed in class, and were more confident about their ability to use this knowledge in the future. However, overall evaluations and satisfaction between the two groups were not reliably different. Implications of these findings and suggestions for future research are discussed. PMID:26973575

  7. Active Learning in Research Methods Classes Is Associated with Higher Knowledge and Confidence, Though not Evaluations or Satisfaction

    PubMed Central

    Allen, Peter J.; Baughman, Frank D.

    2016-01-01

    Research methods and statistics are regarded as difficult subjects to teach, fueling investigations into techniques that increase student engagement. Students enjoy active learning opportunities like hands-on demonstrations, authentic research participation, and working with real data. However, enhanced enjoyment does not always correspond with enhanced learning and performance. In this study, we developed a workshop activity in which students participated in a computer-based experiment and used class-generated data to run a range of statistical procedures. To enable evaluation, we developed a parallel, didactic/canned workshop, which was identical to the activity-based version, except that students were told about the experiment and used a pre-existing/canned dataset to perform their analyses. Tutorial groups were randomized to one of the two workshop versions, and 39 students completed a post-workshop evaluation questionnaire. A series of generalized linear mixed models suggested that, compared to the students in the didactic/canned condition, students exposed to the activity-based workshop displayed significantly greater knowledge of the methodological and statistical issues addressed in class, and were more confident about their ability to use this knowledge in the future. However, overall evaluations and satisfaction between the two groups were not reliably different. Implications of these findings and suggestions for future research are discussed. PMID:26973575

  8. Emerging ethical, legal and social issues associated with stem cell research & and the current role of the moral status of the embryo.

    PubMed

    Zarzeczny, Amy; Caulfield, Timothy

    2009-06-01

    Since its early days, stem cell research, particularly human embryonic stem cell research, has been the focus of intense social debate, and the question of the moral status of the embryo has been a central issue in the controversy. Despite this friction, and while it has yet to obtain widespread success in clinical applications, stem cell research remains a great hope for future advances in healthcare. In this paper, we will discuss the results of our systematic literature review in which we examined recent social science, legal and biomedical discourse, as well as Canadian print media discourse, associated with stem cell research in order to assess the role the question of the moral status of the embryo currently plays in these forums, and to identify what other issues are emerging and receiving attention. This analysis will assist with recognizing the issues which are likely to inform future policy and will facilitate forecasting the probable direction of the continually developing social discourse surrounding stem cell research.

  9. Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective

    PubMed Central

    Hastie, Eric

    2015-01-01

    Abstract Fifty years after the discovery of adeno-associated virus (AAV) and more than 30 years after the first gene transfer experiment was conducted, dozens of gene therapy clinical trials are in progress, one vector is approved for use in Europe, and breakthroughs in virus modification and disease modeling are paving the way for a revolution in the treatment of rare diseases, cancer, as well as HIV. This review will provide a historical perspective on the progression of AAV for gene therapy from discovery to the clinic, focusing on contributions from the Samulski lab regarding basic science and cloning of AAV, optimized large-scale production of vectors, preclinical large animal studies and safety data, vector modifications for improved efficacy, and successful clinical applications. PMID:25807962

  10. Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success--a personal perspective.

    PubMed

    Hastie, Eric; Samulski, R Jude

    2015-05-01

    Fifty years after the discovery of adeno-associated virus (AAV) and more than 30 years after the first gene transfer experiment was conducted, dozens of gene therapy clinical trials are in progress, one vector is approved for use in Europe, and breakthroughs in virus modification and disease modeling are paving the way for a revolution in the treatment of rare diseases, cancer, as well as HIV. This review will provide a historical perspective on the progression of AAV for gene therapy from discovery to the clinic, focusing on contributions from the Samulski lab regarding basic science and cloning of AAV, optimized large-scale production of vectors, preclinical large animal studies and safety data, vector modifications for improved efficacy, and successful clinical applications.

  11. Research on reverse association mechanism of the thermal control performance of conducting optical solar reflector and its antistatic properties

    NASA Astrophysics Data System (ADS)

    Chang, Tianhai; Wu, Shuling; Xing, Zheng; Wei, Xiaoqun

    2014-12-01

    As we know, optical solar reflector (OSR) is used as the thermal control element for communications satellites and other spacecraft. The solar absorption, infrared emissivity and their ratio of OSR, are considered as the main standard of its thermal control performance. OSR is divided into conducting OSR and non-conducting OSR. When using the indium tin oxide (ITO) film coated on the surface of conducting OSR's glass substrate, ITO film will improve OSR's solar absorption rate and reduce the infrared emissivity. That means the thermal control performance will be declined. The paper is aimed to revealing the reverse association mechanism between the thermal control performance of conducting OSR used for spacecraft and the antistatic properties of ITO film. First, we combined the Drude theory with the Thermal radiation theorem to analyze how the antistatic parameters of ITO film impact the solar absorption and the infrared emissivity of OSR. Then,based on the theoretic analysis of main antistatic parameters of ITO, including the surface square resistance, secondary electron emission characteristic, solar absorption rate, infrared emissivity and other optical and electrical parameters. It illustrated that those factors have a strong reverse connection with the thermal control parameters of OSR, and influenced the solar absorption, infrared emissivity and their ratio of OSR. Comparison of the predicted and experimental results demonstrate that when reducing the surface square resistance of the ITO film, the antistatic properties was declined, and increased the value of the OSR solar absorption. On the contrary, reducing the infrared emissivity, It would result in the degradation of OSR's thermal control performance. The study has performed that the reverse association mechanism of conducting OSR can't be ignored. And apparently it shows that if we want to keep its application in the spacecraft thermal control environment and antistatic properties long-term stable, the

  12. Review and Evaluation of Updated Research on the Health Effects Associated with Low-Dose Ionizing Radiation

    SciTech Connect

    Dauer, Lawrence T.; Brooks, Antone L.; Hoel, David G.; Morgan, William F.; Stram, Daniel; Tran, Phung

    2010-07-01

    Potential health effects of low levels of radiation have predominantly been based on those effects observed at high levels of radiation. The authors have reviewed more than 200 percent publications in radiobiology and epidermiology related to low dose radiation and concluded that recent radiobiological studies at low-doses; that doses <100 mSv in a single exposure appear to be too small to allow epidermiological detection of statistically significant excess cancers in the presence of naturally occurring cancers; that low dose radiation research should to holistic, systems-based approaches to develop models that define the shape of the dose-response relationships at low doses; and that these results should be combined with the latest epidermiology to produce a comprehensive understanding of radiation effects that addresses both damage, likely with a linear effect, and response, possibly with non-linear consequences.

  13. SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink.

    PubMed

    Carr, D F; O'Meara, H; Jorgensen, A L; Campbell, J; Hobbs, M; McCann, G; van Staa, T; Pirmohamed, M

    2013-12-01

    This study aimed to determine whether patients with statin-induced myopathy could be identified using the United Kingdom Clinical Practice Research Datalink, whether DNA could be obtained, and whether previously reported associations of statin myopathy with the SLCO1B1 c.521T>C and COQ2 rs4693075 polymorphisms could be replicated. Seventy-seven statin-induced myopathy patients (serum creatine phosphokinase (CPK) > 4× upper limit of normal (ULN)) and 372 statin-tolerant controls were identified and recruited. Multiple logistic regression analysis showed the SLCO1B1 c.521T>C single-nucleotide polymorphism to be a significant risk factor (P = 0.009), with an odds ratio (OR) per variant allele of 2.06 (1.32-3.15) for all myopathy and 4.09 (2.06-8.16) for severe myopathy (CPK > 10× ULN, and/or rhabdomyolysis; n = 23). COQ2 rs4693075 was not associated with myopathy. Meta-analysis showed an association between c.521C>T and simvastatin-induced myopathy, although power for other statins was limited. Our data replicate the association of SLCO1B1 variants with statin-induced myopathy. Furthermore, we demonstrate how electronic medical records provide a time- and cost-efficient means of recruiting patients with severe adverse drug reactions for pharmacogenetic studies.

  14. National Medical Association/National Institutes of Health Workshop on Violence and the Conduct of Research. Workgroup Proceedings, June 1-2, 1994.

    PubMed Central

    Martinez, R. A.; Pointer, A.; Vereen, D.; Marks, S. F.

    1995-01-01

    The physical, economic, and mental toll caused by violence in the United States has put tremendous pressure on American medical, political, religious, and social institutions. The impact in urban neighborhoods has been especially harrowing, forcing African-American organizations to address this domestic problem with ideas and suggestions unique to their philosophies and collective talents. This article contains general perspectives and commentary from physicians and social science experts who participated in a workshop sponsored by the National Medical Association, the National Institute of Drug Abuse, and the National Institute of Mental Health to discuss topics on violence, its health consequences, and the conduct of research in the African-American community. PMID:8907813

  15. SuperQuads: a day in the life; research reviews: color-number association, finger-length ratios, twinning diets, athletic pairs.

    PubMed

    Segal, Nancy L

    2006-08-01

    The nature and frequency of quadruplet births are reviewed, followed by a close-up look at the 6-year-old monozygotic Mathias quadruplets. This essay is followed by reviews of new twin research on color-number association, male-female twins' finger-length ratios, and links between twinning and dietary practices. The article finishes by focusing on unusual twin athletes in football, basketball and golf, and on twin co-authors of a new book on the 1972 silver medal victory by the United States hockey team.

  16. Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research

    PubMed Central

    Jensen, Victoria S; Porsgaard, Trine; Lykkesfeldt, Jens; Hvid, Henning

    2016-01-01

    Laboratory rodents are available as either genetically defined inbred strains or genetically undefined outbred stocks. As outbred rodents are generally thought to display a higher level of phenotypic variation compared to inbred strains, it has been argued that experimental studies should preferentially be performed by using inbred rodents. However, very few studies with adequate sample sizes have in fact compared phenotypic variation between inbred strains and outbred stocks of rodents and moreover, these studies have not reached consistent conclusions. The aim of the present study was to compare the phenotypic variation in commonly used experimental readouts within obesity and diabetes research, for four of the most frequently used mouse strains: inbred C57BL/6 and BALB/c and outbred NMRI and CD-1 mice. The variation for all readouts was examined by calculating the coefficient of variation (CV), i.e., the relative variation, including a 95% confidence interval for the CV. We observed that for the majority of the selected readouts, inbred and outbred mice showed comparable phenotypic variation. The observed variation appeared highly influenced by strain choice and type of readout, which suggests that these collectively would serve as more predictive of the phenotypic variation than the more general classification of mice as inbred or outbred based on genetic heterogeneity.

  17. Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research.

    PubMed

    Jensen, Victoria S; Porsgaard, Trine; Lykkesfeldt, Jens; Hvid, Henning

    2016-01-01

    Laboratory rodents are available as either genetically defined inbred strains or genetically undefined outbred stocks. As outbred rodents are generally thought to display a higher level of phenotypic variation compared to inbred strains, it has been argued that experimental studies should preferentially be performed by using inbred rodents. However, very few studies with adequate sample sizes have in fact compared phenotypic variation between inbred strains and outbred stocks of rodents and moreover, these studies have not reached consistent conclusions. The aim of the present study was to compare the phenotypic variation in commonly used experimental readouts within obesity and diabetes research, for four of the most frequently used mouse strains: inbred C57BL/6 and BALB/c and outbred NMRI and CD-1 mice. The variation for all readouts was examined by calculating the coefficient of variation (CV), i.e., the relative variation, including a 95% confidence interval for the CV. We observed that for the majority of the selected readouts, inbred and outbred mice showed comparable phenotypic variation. The observed variation appeared highly influenced by strain choice and type of readout, which suggests that these collectively would serve as more predictive of the phenotypic variation than the more general classification of mice as inbred or outbred based on genetic heterogeneity. PMID:27648148

  18. Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research

    PubMed Central

    Jensen, Victoria S; Porsgaard, Trine; Lykkesfeldt, Jens; Hvid, Henning

    2016-01-01

    Laboratory rodents are available as either genetically defined inbred strains or genetically undefined outbred stocks. As outbred rodents are generally thought to display a higher level of phenotypic variation compared to inbred strains, it has been argued that experimental studies should preferentially be performed by using inbred rodents. However, very few studies with adequate sample sizes have in fact compared phenotypic variation between inbred strains and outbred stocks of rodents and moreover, these studies have not reached consistent conclusions. The aim of the present study was to compare the phenotypic variation in commonly used experimental readouts within obesity and diabetes research, for four of the most frequently used mouse strains: inbred C57BL/6 and BALB/c and outbred NMRI and CD-1 mice. The variation for all readouts was examined by calculating the coefficient of variation (CV), i.e., the relative variation, including a 95% confidence interval for the CV. We observed that for the majority of the selected readouts, inbred and outbred mice showed comparable phenotypic variation. The observed variation appeared highly influenced by strain choice and type of readout, which suggests that these collectively would serve as more predictive of the phenotypic variation than the more general classification of mice as inbred or outbred based on genetic heterogeneity. PMID:27648148

  19. Research to Reality: Putting VET Research To Work. Proceedings of the Australian Vocational Education and Training Research Association (AVETRA) Conference (4th, Adelaide, Australia, March 28-30, 2001).

    ERIC Educational Resources Information Center

    Australian Vocational Education and Training Research Association, Alexandria.

    This document contains 95 papers and summaries of 5 poster sessions from an Australian conference on putting vocational education and training (VET) research to work. The following are among the areas covered in the papers: factors affecting VET graduates' employability over time; technical and further education (TAFE) institutes as models of…

  20. Association between mental demands at work and cognitive functioning in the general population – results of the health study of the Leipzig research center for civilization diseases (LIFE)

    PubMed Central

    2014-01-01

    Background The level of mental demands in the workplace is rising. The present study investigated whether and how mental demands at work are associated with cognitive functioning in the general population. Methods The analysis is based on data of the Health Study of the Leipzig Research Centre for Civilization Disease (LIFE). 2,725 participants aged 40–80 years underwent cognitive testing (Trail-Making Test, Verbal Fluency Test) and provided information on their occupational situation. Participants over the age of 65 years additionally completed the Mini-Mental State Examination. Mental demands at work were rated by a standardized classification system (O*NET). The association between mental demands and cognitive functioning was analyzed using Generalized Linear Modeling (GENLIN) adjusted for age, gender, self-regulation, working hour status, education, and health-related factors. Results Univariate as well as multivariate analyses demonstrated significant and highly consistent effects of higher mental demands on better performance in cognitive testing. The results also indicated that the effects are independent of education and intelligence. Moreover, analyses of retired individuals implied a significant association between high mental demands at work of the job they once held and a better cognitive functioning in old age. Conclusions In sum, our findings suggest a significant association between high mental demands at work and better cognitive functioning. In this sense, higher levels of mental demands – as brought about by technological changes in the working environment – may also have beneficial effects for the society as they could increase cognitive capacity levels and might even delay cognitive decline in old age. PMID:24914403

  1. What Medical Oncologist Residents Think about the Italian Speciality Schools: A Survey of the Italian Association of Medical Oncology (AIOM) on Educational, Clinical and Research Activities

    PubMed Central

    Moretti, Anna; De Angelis, Carmine; Lambertini, Matteo; Cremolini, Chiara; Imbimbo, Martina; Berardi, Rossana; Di Maio, Massimo; Cascinu, Stefano; La Verde, Nicla

    2016-01-01

    Background and objectives Relevant heterogeneity exists among Postgraduate Schools in Medical Oncology, also within the same country. In order to provide a comprehensive overview of the landscape of Italian Postgraduate Schools in Medical Oncology, the Italian Association of Medical Oncology (AIOM) undertook an online survey, inviting all the residents to describe their daily activities and to express their overall satisfaction about their programs. Methods A team composed of five residents and three consultants in medical oncology prepared a 38 items questionnaire that was published online in a reserved section, accessible through a link sent by e-mail. Residents were invited to anonymously fill in the questionnaire that included the following sub-sections: quality of teaching, clinical and research activity, overall satisfaction. Results Three-hundred and eleven (57%) out of 547 invited residents filled in the questionnaire. Two-hundred and twenty-three (72%) participants declared that attending lessons was frequently difficult and 153 (49%) declared they did not gain substantial improvement in their knowledge from them. Fifty-five percent stated that they did not receive lessons on palliative care. Their overall judgment about didactic activity was low in 63% of the interviewed. The satisfaction for clinical activity was in 86% of cases good: 84% recognized that, during the training period, they acquired a progressive independence on patients' management. About research activity, the majority (79%) of participants in the survey was actively engaged in managing patients included in clinical trials but the satisfaction level for the involvement in research activities was quite low (54%). Overall, 246 residents (79%) gave a positive global judgment of their Medical Oncology Schools. Conclusions The landscape of Italian Postgraduate Schools in Medical Oncology is quite heterogeneous across the country. Some improvements in the organization of teaching and in the

  2. Medication Related Osteonecrosis of the Jaw: 2015 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons

    PubMed Central

    Kim, Kyoung Min; Rhee, Yumie; Kwon, Yong-Dae; Kwon, Tae-Geon; Lee, Jeong Keun

    2015-01-01

    Bisphosphonates are the most widely prescribed drugs for the treatment of osteoporosis, and are also used in malignant bone metastases, multiple myeloma, and Paget's disease, and provide therapeutic efficacy on those diseases. However, it was reported that occurrence of osteonecrosis of the jaw (ONJ) could be related with bisphosphonate exposures, and there have been many cases regarding this issue. Therefore, a clearer definition and treatment guidelines were needed for this disease. The American Society for Bone and Mineral Research (ASBMR) and American Association of Oral and Maxillofacial Surgeons (AAOMS) reported statements on bisphosphonate-related ONJ (BRONJ), and a revised version was recently presented. In the revised edition, the diagnosis BRONJ was changed to medication-related ONJ (MRONJ), which reflects a consideration of the fact that ONJ also occurs for denosumab, a bone resorption inhibitor of the receptor activator of nuclear factor-kappa B ligand (RANKL) antibody family, and bevacizumab, an anti-angiogenesis inhibitor. In 2009, a statement on ONJ was also reported locally by a relevant organization, which has served as basis for clinical treatment in Korea. In addition to the new official stance of the AAOMS and ASBMR, with an increasing pool of ONJ clinical experience, a revised version of the 2009 local statement is needed. As such, the Korean Society for Bone and Mineral Research (KSBMR) and the Korean Association of Oral and Maxillofacial Surgeons (KAOMS) have collectively formed a committee for the preparation of an official statement on MRONJ, and have reviewed recent local and international data to propose guidelines customized for the local Korean situation. PMID:26713306

  3. Is the Physical Functioning of Older Adults with Diabetes Associated with the Processes and Outcomes of Care? Evidence from Translating Research Into Action for Diabetes (TRIAD)

    PubMed Central

    Lee, Pearl G.; McEwen, Laura N.; Waitzfelder, Beth; Subramanian, Usha; Karter, Andrew J.; Mangione, Carol M.; Herman, William H.

    2013-01-01

    Aims To examine the relationship between physical function limitations and diabetes self-management, processes of care, and intermediate outcomes in adults ≥65 years of age with type 2 diabetes. Methods We studied 1,796 participants 65 years of age and older in managed care health plans enrolled in Translating Research into Action for Diabetes (TRIAD). Physical functioning was assessed at baseline with the Physical Component Summary of the Short Form-12 (SF-12) Health Survey. Diabetes self-management was assessed with follow-up surveys, and processes of care (eye exams, urine microalbumin testing, foot exams, etc.) and intermediate health outcomes (HbA1c, blood pressure, LDL-c) were assessed with medical chart reviews. Multivariate regression models were constructed to examine the associations between physical function limitations and outcomes. Results Frequency of eye exams (OR 0.69, 95% CI 0.49 - 0.99) was the only process of care that was worse for participants with physical function limitations (n=573) compared to those without limitations (n=618). Neither self-management nor intermediate outcomes differed by whether patients had or did not have physical function limitations. Conclusion Limitations in physical functioning as assessed by the SF-12 were not associated with substantial difference in diabetes care in adults ≥65 years of age enrolled in managed care health plans. PMID:22268866

  4. [The Association of Urological Oncology (AOU) German Cancer Society e.V. The competent counterpart for research in Uro-oncology].

    PubMed

    Rexer, H

    2005-04-01

    With more than 85,000 newly diagnosed cancers per year, uro-oncology alone represents a significant part in the field of oncology in Germany. Therefore, the Task Group for Uro-Oncology (The Association of Urogenital Oncology, AUO) of the German Cancer Association (DKG) was founded in 1989 to enforce high quality in research on urological cancer. The main aim has been to improve the quality of clinical cancer studies. The board of the AUO reviews, certifies and gives accreditation to study protocols with respect to GCP standards, likelihood of realisation and scientific impact of the study objectives. To support enrolment of patients, the AUO initiated a study group of more than 85 clinical centers of excellence and publishes timely details on the different studies in the appropriate media. Moreover, the members of the AUO board organize seminars, scientific meetings and pharmaceutical hearings. In this article, the organisation's structure is described in detail. Various aspects of AUO work, carried out over the years, are highlighted, and data presented on the outcome of studies.

  5. Quantitative genetic research on sleep: a review of normal sleep, sleep disturbances and associated emotional, behavioural, and health-related difficulties.

    PubMed

    Barclay, Nicola L; Gregory, Alice M

    2013-02-01

    Over the past 50 years, well over 100 twin studies have focussed on understanding factors contributing to variability in normal sleep-wake characteristics and sleep disturbances. Whilst we have gained a great deal from these studies, there is still much to be learnt. Twin studies can be used in multiple ways to answer questions beyond simply estimating heritability. This paper provides a comprehensive review of some of the most important findings from twin studies relating to sleep to date, with a focus on studies investigating genetic and environmental influences contributing to i) objective and subjective measures of normal sleep characteristics (e.g., sleep stage organisation, sleep quality); as well as sleep disturbances and disorders such as dyssomnias (e.g., insomnia, narcolepsy) and parasomnias (e.g., sleepwalking, bruxism); ii) the persistence of sleep problems from childhood to adulthood, and the possibility that the aetiological influences on sleep change with age; iii) the associations between sleep disturbances, emotional, behavioural and health-related problems; and iv) processes of gene-environment correlation and interaction. We highlight avenues for further research, emphasising the need to further consider the aetiology of longitudinal associations between sleep disturbances and psychopathology; the genetic and environmental overlap between sleep and numerous phenotypes; and processes of gene-environment interplay and epigenetics. PMID:22560641

  6. Childhood onset arthritis is associated with an increased risk of fracture: a population based study using the General Practice Research Database

    PubMed Central

    Burnham, J M; Shults, J; Weinstein, R; Lewis, J D; Leonard, M B

    2006-01-01

    Background Childhood onset arthritis is associated with low bone mass and strength. Objective To determine whether childhood onset arthritis is associated with greater fracture risk. Methods In a retrospective cohort study all subjects with onset of arthritis between 1 and 19 years of age in the United Kingdom General Practice Research Database were identified. As controls, all sex and age matched subjects from a practice that included a subject with arthritis were included. Incidence rate ratios (IRRs) for first fracture were generated using Mantel‐Haenszel methods and Poisson regression. Results 1939 subjects with arthritis (51% female) and 207 072 controls (53% female) were identified. The median age at arthritis diagnosis was 10.9 years. A total of 129 (6.7%) first fractures were noted in subjects with arthritis compared with 6910 (3.3%) in controls over a median follow up of 3.90 and 3.95 years in the subjects with arthritis and controls, respectively. The IRR (95% confidence interval) for first fracture among subjects with arthritis, compared with controls, according to the age at the start of follow up were 1.49 (0.91 to 2.31) for age <10 years, 3.13 (2.21 to 4.33) at 10–15 years, 1.75 (1.18 to 2.51) at 15–20 years, 1.40 (0.91 to 2.08) at 20–45 years, and 3.97 (2.23 to 6.59) at >45 years. Conclusions Childhood onset arthritis is associated with a clinically significant increased risk of fracture in children, adolescents and, possibly, adults. Studies are urgently needed to characterise the determinants of structural bone abnormalities in childhood arthritis and devise prevention and treatment strategies. PMID:16627541

  7. Diagnostic Intervals and Its Association with Breast, Prostate, Lung and Colorectal Cancer Survival in England: Historical Cohort Study Using the Clinical Practice Research Datalink

    PubMed Central

    Redaniel, Maria Theresa; Martin, Richard M.; Ridd, Matthew J.; Wade, Julia; Jeffreys, Mona

    2015-01-01

    Rapid diagnostic pathways for cancer have been implemented, but evidence whether shorter diagnostic intervals (time from primary care presentation to diagnosis) improves survival is lacking. Using the Clinical Practice Research Datalink, we identified patients diagnosed with female breast (8,639), colorectal (5,912), lung (5,737) and prostate (1,763) cancers between 1998 and 2009, and aged >15 years. Presenting symptoms were classified as alert or non-alert, according to National Institute for Health and Care Excellence guidance. We used relative survival and excess risk modeling to determine associations between diagnostic intervals and five-year survival. The survival of patients with colorectal, lung and prostate cancer was greater in those with alert, compared with non-alert, symptoms, but findings were opposite for breast cancer. Longer diagnostic intervals were associated with lower mortality for colorectal and lung cancer patients with non-alert symptoms, (colorectal cancer: Excess Hazards Ratio, EHR >6 months vs <1 month: 0.85; 95% CI: 0.72-1.00; Lung cancer: EHR 3-6 months vs <1 month: 0.87; 95% CI: 0.80-0.95; EHR >6 months vs <1 month: 0.81; 95% CI: 0.74-0.89). Prostate cancer mortality was lower in patients with longer diagnostic intervals, regardless of type of presenting symptom. The association between diagnostic intervals and cancer survival is complex, and should take into account cancer site, tumour biology and clinical practice. Nevertheless, unnecessary delay causes patient anxiety and general practitioners should continue to refer patients with alert symptoms via the cancer pathways, and actively follow-up patients with non-alert symptoms in the community. PMID:25933397

  8. Preventing and Lessening Exacerbations of Asthma in School-aged children Associated with a New Term (PLEASANT): Recruiting Primary Care Research Sites–the PLEASANT experience

    PubMed Central

    Horspool, Michelle J; Julious, Steven A; Mooney, Cara; May, Robin; Sully, Ben; Smithson, W Henry

    2015-01-01

    Background: Recruitment of general practices and their patients into research studies is frequently reported as a challenge. The Preventing and Lessening Exacerbations of Asthma in School-aged children Associated with a New Term (PLEASANT) trial recruited 142 general practices, across England and Wales and delivered the study intervention to time and target. Aims: To describe the process of recruitment used within the cluster randomised PLEASANT trial and present results on factors that influenced recruitment. Methods: Data were collected on the number of and types of contact used to gain expression of interest and subsequent randomisation into the PLEASANT trial. Practice size and previous research experience were also collected. Results: The mean number of contacts required to gain expression of interest were m=3.01 (s.d. 1.6) and total number of contacts from initial invitation to randomisation m=6.8 (s.d. 3.5). Previous randomised controlled trial involvement (hazard ratio (HR)=1.81 (confidence interval (CI) 95%, 1.55–2.11) P<0.001) and number of studies a practice had previously engaged in (odds ratio (OR) 1.91 (CI 95%, (1.52–2.42)) P<0.001), significantly influenced whether a practice would participate in PLEASANT. Practice size was not a significant deciding factor (OR=1.04 (95% CI 0.99–1.08) P=0.137). Conclusions: Recruitment to time and target can be achieved in general practice. The amount of resource required for site recruitment should not, however, be underestimated and multiple strategies for contacting practices should be considered. General practitioners with more research experience are more likely to participate in studies. PMID:26562491

  9. Association between funding source, methodological quality and research outcomes in randomized controlled trials of synbiotics, probiotics and prebiotics added to infant formula: A Systematic Review

    PubMed Central

    2013-01-01

    Background There is little or no information available on the impact of funding by the food industry on trial outcomes and methodological quality of synbiotics, probiotics and prebiotics research in infants. The objective of this study was to compare the methodological quality, outcomes of food industry sponsored trials versus non industry sponsored trials, with regards to supplementation of synbiotics, probiotics and prebiotics in infant formula. Methods A comprehensive search was conducted to identify published and unpublished randomized clinical trials (RCTs). Cochrane methodology was used to assess the risk of bias of included RCTs in the following domains: 1) sequence generation; 2) allocation concealment; 3) blinding; 4) incomplete outcome data; 5) selective outcome reporting; and 6) other bias. Clinical outcomes and authors’ conclusions were reported in frequencies and percentages. The association between source of funding, risk of bias, clinical outcomes and conclusions were assessed using Pearson’s Chi-square test and the Fisher’s exact test. A p-value < 0.05 was statistically significant. Results Sixty seven completed and 3 on-going RCTs were included. Forty (59.7%) were funded by food industry, 11 (16.4%) by non-industry entities and 16 (23.9%) did not specify source of funding. Several risk of bias domains, especially sequence generation, allocation concealment and blinding, were not adequately reported. There was no significant association between the source of funding and sequence generation, allocation concealment, blinding and selective reporting, majority of reported clinical outcomes or authors’ conclusions. On the other hand, source of funding was significantly associated with the domains of incomplete outcome data, free of other bias domains as well as reported antibiotic use and conclusions on weight gain. Conclusion In RCTs on infants fed infant formula containing probiotics, prebiotics or synbiotics, the source of funding did not

  10. Youth in Transition: The Challenges of Generational Change in Asia. Proceedings of the Biennial General Conference of the Association of Asian Social Science Research Councils (15th, Canberra, Australia, 2005)

    ERIC Educational Resources Information Center

    Gale, Fay, Ed.; Fahey, Stephanie, Ed.

    2005-01-01

    This book originates from a conference of the Association of Asian Social Science Research Councils and contains writings and research reports on Youth in Transition in the Asia and Pacific region. The definition of "youth" varies from country to country and ranges between the ages of 10 to 35. The publication summarizes issues in the region,…

  11. Research Visibility: Research and Evaluation.

    ERIC Educational Resources Information Center

    Brandon, George, L., Ed.

    1971-01-01

    The purpose of this research review was to demonstrate the relationship between the research and evaluation activities and the operational programs of the American Vocational Association (AVA) as it was presented to the 1970 annual convention. The 18 research reports are reviewed under these categories: (1) Awareness, Maturity, and Performance,…

  12. Biomass Gasification Research Facility Final Report

    SciTech Connect

    Snyder, Todd R.; Bush, Vann; Felix, Larry G.; Farthing, William E.; Irvin, James H.

    2007-09-30

    also addressed safety concerns associated with thermochemical process operation that constrain the location and configuration of potential gas analysis equipment. Initial analyzer costs, reliability, accuracy, and operating and maintenance costs were also considered prior to the assembly of suitable analyzers for this work. Initial tests at GTI’s Flex-Fuel Test Facility (FFTF) in late 2004 and early 2005 successfully demonstrated the transport and subsequent analysis of a single depressurized, heat-traced syngas stream to a single analyzer (an Industrial Machine and Control Corporation (IMACC) Fourier-transform infrared spectrometer (FT-IR)) provided by GTI. In March 2005, our sampling approach was significantly expanded when this project participated in the U.S. DOE’s Novel Gas Cleaning (NGC) project. Syngas sample streams from three process locations were transported to a distribution manifold for selectable analysis by the IMACC FT-IR, a Stanford Research Systems QMS300 Mass Spectrometer (SRS MS) obtained under this Cooperative Agreement, and a Varian micro gas chromatograph with thermal conductivity detector (μGC) provided by GTI. A syngas stream from a fourth process location was transported to an Agilent Model 5890 Series II gas chromatograph for highly sensitive gas analyses. The on-line analyses made possible by this sampling system verified the syngas cleaning achieved by the NGC process. In June 2005, GTI collaborated with Weyerhaeuser to characterize the ChemrecTM black liquor gasifier at Weyerhaeuser’s New Bern, North Carolina pulp mill. Over a ten-day period, a broad range of process operating conditions were characterized with the IMACC FT-IR, the SRS MS, the Varian μGC, and an integrated Gas Chromatograph, Mass Selective Detector, Flame Ionization Detector and Sulfur Chemiluminescence Detector (GC/MSD/FID/SCD) system acquired under this Cooperative Agreement from Wasson-ECE. In this field application, a single sample stream was extracted from

  13. Burn therapist contributions to the American Burn Association and the Journal of Burn Care and Research: a 45th anniversary review.

    PubMed

    Richard, Reginald

    2014-01-01

    The year 2013 marked the 45th anniversary of American Burn Association (ABA) annual meetings. At this significant juncture, a review of contributions of its members is appropriate to celebrate this milestone. Since the first ABA annual meeting and the initiation of the Journal of Burn Care and Research (JBCR), burn therapists, including both occupational and physical therapists, have grown to become integral members of the ABA, and their contributions among all members are highlighted. A systematic manual review of both ABA annual meeting proceedings and the JBCR was performed. The contributions of burn therapists to the ABA as a whole were classified, cataloged, and hand counted. Areas included: 1) quantifying ABA abstract and JBCR articles on authorship and subject matter, 2) representation on ABA committees; 3) participation in special activities; and 4) other recognitions. Burn therapists comprise 9.7% of ABA members overall. During the course of the first 44 ABA meetings, 8381 abstracts have been presented. Of this number, 634 (7.6%) have been delivered by burn therapists as lead authors. Through the end of 2011, no less than 3207 publications by all disciplines have appeared in JBCR. The vast majority of articles have been written by physicians, followed by doctorate-trained professionals. One hundred-forty therapists have 249 publications (7.8%) to their credit. For both abstracts and articles, the top three subject matter topics have been: scarring, splints and casts, and outcomes. Numerous burn therapists have served as faculty and moderators at ABA annual meetings and on ABA committees including JBCR. Burn therapists have made significant contributions to the JBCR and in support of the ABA and its annual meetings over the past 45 years from the clinical, scientific, and Association perspectives.

  14. Burn therapist contributions to the American Burn Association and the Journal of Burn Care and Research: a 45th anniversary review.

    PubMed

    Richard, Reginald

    2014-01-01

    The year 2013 marked the 45th anniversary of American Burn Association (ABA) annual meetings. At this significant juncture, a review of contributions of its members is appropriate to celebrate this milestone. Since the first ABA annual meeting and the initiation of the Journal of Burn Care and Research (JBCR), burn therapists, including both occupational and physical therapists, have grown to become integral members of the ABA, and their contributions among all members are highlighted. A systematic manual review of both ABA annual meeting proceedings and the JBCR was performed. The contributions of burn therapists to the ABA as a whole were classified, cataloged, and hand counted. Areas included: 1) quantifying ABA abstract and JBCR articles on authorship and subject matter, 2) representation on ABA committees; 3) participation in special activities; and 4) other recognitions. Burn therapists comprise 9.7% of ABA members overall. During the course of the first 44 ABA meetings, 8381 abstracts have been presented. Of this number, 634 (7.6%) have been delivered by burn therapists as lead authors. Through the end of 2011, no less than 3207 publications by all disciplines have appeared in JBCR. The vast majority of articles have been written by physicians, followed by doctorate-trained professionals. One hundred-forty therapists have 249 publications (7.8%) to their credit. For both abstracts and articles, the top three subject matter topics have been: scarring, splints and casts, and outcomes. Numerous burn therapists have served as faculty and moderators at ABA annual meetings and on ABA committees including JBCR. Burn therapists have made significant contributions to the JBCR and in support of the ABA and its annual meetings over the past 45 years from the clinical, scientific, and Association perspectives. PMID:24823340

  15. Organization of research team for nano-associated safety assessment in effort to study nanotoxicology of zinc oxide and silica nanoparticles.

    PubMed

    Kim, Yu-Ri; Park, Sung Ha; Lee, Jong-Kwon; Jeong, Jayoung; Kim, Ja Hei; Meang, Eun-Ho; Yoon, Tae Hyun; Lim, Seok Tae; Oh, Jae-Min; An, Seong Soo A; Kim, Meyoung-Kon

    2014-01-01

    Currently, products made with nanomaterials are used widely, especially in biology, bio-technologies, and medical areas. However, limited investigations on potential toxicities of nanomaterials are available. Hence, diverse and systemic toxicological data with new methods for nanomaterials are needed. In order to investigate the nanotoxicology of nanoparticles (NPs), the Research Team for Nano-Associated Safety Assessment (RT-NASA) was organized in three parts and launched. Each part focused on different contents of research directions: investigators in part I were responsible for the efficient management and international cooperation on nano-safety studies; investigators in part II performed the toxicity evaluations on target organs such as assessment of genotoxicity, immunotoxicity, or skin penetration; and investigators in part III evaluated the toxicokinetics of NPs with newly developed techniques for toxicokinetic analyses and methods for estimating nanotoxicity. The RT-NASA study was carried out in six steps: need assessment, physicochemical property, toxicity evaluation, toxicokinetics, peer review, and risk communication. During the need assessment step, consumer responses were analyzed based on sex, age, education level, and household income. Different sizes of zinc oxide and silica NPs were purchased and coated with citrate, L-serine, and L-arginine in order to modify surface charges (eight different NPs), and each of the NPs were characterized by various techniques, for example, zeta potentials, scanning electron microscopy, and transmission electron microscopy. Evaluation of the "no observed adverse effect level" and systemic toxicities of all NPs were performed by thorough evaluation steps and the toxicokinetics step, which included in vivo studies with zinc oxide and silica NPs. A peer review committee was organized to evaluate and verify the reliability of toxicity tests, and the risk communication step was also needed to convey the current findings

  16. Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting and research needs. A joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group.

    PubMed

    Heinemann, Lutz; Fleming, G Alexander; Petrie, John R; Holl, Reinhard W; Bergenstal, Richard M; Peters, Anne L

    2015-05-01

    Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), is an important and evolving form of insulin delivery, which is mainly used for people with type 1 diabetes. However, even with modern insulin pumps, errors of insulin infusion can occur due to pump failure, insulin infusion set (IIS) blockage, infusion site problems, insulin stability issues, user error or a combination of these. Users are therefore exposed to significant and potentially fatal hazards: interruption of insulin infusion can result in hyperglycaemia and ketoacidosis; conversely, delivery of excessive insulin can cause severe hypoglycaemia. Nevertheless, the available evidence on the safety and efficacy of CSII remains limited. The European Association for the Study of Diabetes (EASD) and American Diabetes Association (ADA) have therefore joined forces to review the systems in place for evaluating the safety of pumps from a clinical perspective. We found that useful information held by the manufacturing companies is not currently shared in a sufficiently transparent manner. Public availability of adverse event (AE) reports on the US Food and Drug Administration's Manufacturer and User Facility Device Experience (MAUDE) database is potentially a rich source of safety information but is insufficiently utilised due to the current configuration of the system; the comparable database in Europe (European Databank on Medical Devices, EUDAMED) is not publicly accessible. Many AEs appear to be attributable to human factors and/or user error, but the extent to which manufacturing companies are required by regulators to consider the interactions of users with the technical features of their products is limited. The clinical studies required by regulators prior to marketing are small and over-reliant on bench testing in relation to 'predicate' products. Once a pump is available on the market, insufficient data are made publicly available on its long-term use in a real

  17. Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting, and research needs: a joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group.

    PubMed

    Heinemann, Lutz; Fleming, G Alexander; Petrie, John R; Holl, Reinhard W; Bergenstal, Richard M; Peters, Anne L

    2015-04-01

    Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), is an important and evolving form of insulin delivery, which is mainly used for people with type 1 diabetes. However, even with modern insulin pumps, errors of insulin infusion can occur due to pump failure, insulin infusion set (IIS) blockage, infusion site problems, insulin stability issues, user error, or a combination of these. Users are therefore exposed to significant and potentially fatal hazards: interruption of insulin infusion can result in hyperglycemia and ketoacidosis; conversely, delivery of excessive insulin can cause severe hypoglycemia. Nevertheless, the available evidence on the safety and efficacy of CSII remains limited. The European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) have therefore joined forces to review the systems in place for evaluating the safety of pumps from a clinical perspective. We found that useful information held by the manufacturing companies is not currently shared in a sufficiently transparent manner. Public availability of adverse event (AE) reports on the US Food and Drug Administration's Manufacturer and User Facility Device Experience (MAUDE) database is potentially a rich source of safety information but is insufficiently utilized due to the current configuration of the system; the comparable database in Europe (European Databank on Medical Devices [EUDAMED]) is not publicly accessible. Many AEs appear to be attributable to human factors and/or user error, but the extent to which manufacturing companies are required by regulators to consider the interactions of users with the technical features of their products is limited. The clinical studies required by regulators prior to marketing are small and over-reliant on bench testing in relation to "predicate" products. Once a pump is available on the market, insufficient data are made publicly available on its long-term use in a real

  18. Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting, and research needs: a joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group.

    PubMed

    Heinemann, Lutz; Fleming, G Alexander; Petrie, John R; Holl, Reinhard W; Bergenstal, Richard M; Peters, Anne L

    2015-04-01

    Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), is an important and evolving form of insulin delivery, which is mainly used for people with type 1 diabetes. However, even with modern insulin pumps, errors of insulin infusion can occur due to pump failure, insulin infusion set (IIS) blockage, infusion site problems, insulin stability issues, user error, or a combination of these. Users are therefore exposed to significant and potentially fatal hazards: interruption of insulin infusion can result in hyperglycemia and ketoacidosis; conversely, delivery of excessive insulin can cause severe hypoglycemia. Nevertheless, the available evidence on the safety and efficacy of CSII remains limited. The European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) have therefore joined forces to review the systems in place for evaluating the safety of pumps from a clinical perspective. We found that useful information held by the manufacturing companies is not currently shared in a sufficiently transparent manner. Public availability of adverse event (AE) reports on the US Food and Drug Administration's Manufacturer and User Facility Device Experience (MAUDE) database is potentially a rich source of safety information but is insufficiently utilized due to the current configuration of the system; the comparable database in Europe (European Databank on Medical Devices [EUDAMED]) is not publicly accessible. Many AEs appear to be attributable to human factors and/or user error, but the extent to which manufacturing companies are required by regulators to consider the interactions of users with the technical features of their products is limited. The clinical studies required by regulators prior to marketing are small and over-reliant on bench testing in relation to "predicate" products. Once a pump is available on the market, insufficient data are made publicly available on its long-term use in a real

  19. Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting and research needs. A joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group.

    PubMed

    Heinemann, Lutz; Fleming, G Alexander; Petrie, John R; Holl, Reinhard W; Bergenstal, Richard M; Peters, Anne L

    2015-05-01

    Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), is an important and evolving form of insulin delivery, which is mainly used for people with type 1 diabetes. However, even with modern insulin pumps, errors of insulin infusion can occur due to pump failure, insulin infusion set (IIS) blockage, infusion site problems, insulin stability issues, user error or a combination of these. Users are therefore exposed to significant and potentially fatal hazards: interruption of insulin infusion can result in hyperglycaemia and ketoacidosis; conversely, delivery of excessive insulin can cause severe hypoglycaemia. Nevertheless, the available evidence on the safety and efficacy of CSII remains limited. The European Association for the Study of Diabetes (EASD) and American Diabetes Association (ADA) have therefore joined forces to review the systems in place for evaluating the safety of pumps from a clinical perspective. We found that useful information held by the manufacturing companies is not currently shared in a sufficiently transparent manner. Public availability of adverse event (AE) reports on the US Food and Drug Administration's Manufacturer and User Facility Device Experience (MAUDE) database is potentially a rich source of safety information but is insufficiently utilised due to the current configuration of the system; the comparable database in Europe (European Databank on Medical Devices, EUDAMED) is not publicly accessible. Many AEs appear to be attributable to human factors and/or user error, but the extent to which manufacturing companies are required by regulators to consider the interactions of users with the technical features of their products is limited. The clinical studies required by regulators prior to marketing are small and over-reliant on bench testing in relation to 'predicate' products. Once a pump is available on the market, insufficient data are made publicly available on its long-term use in a real

  20. Informatics, evidence-based care, and research; implications for national policy: a report of an American Medical Informatics Association health policy conference.

    PubMed

    Bloomrosen, Meryl; Detmer, Don E

    2010-01-01

    There is an increased level of activity in the biomedical and health informatics world (e-prescribing, electronic health records, personal health records) that, in the near future, will yield a wealth of available data that we can exploit meaningfully to strengthen knowledge building and evidence creation, and ultimately improve clinical and preventive care. The American Medical Informatics Association (AMIA) 2008 Health Policy Conference was convened to focus and propel discussions about informatics-enabled evidence-based care, clinical research, and knowledge management. Conference participants explored the potential of informatics tools and technologies to improve the evidence base on which providers and patients can draw to diagnose and treat health problems. The paper presents a model of an evidence continuum that is dynamic, collaborative, and powered by health informatics technologies. The conference's findings are described, and recommendations on terminology harmonization, facilitation of the evidence continuum in a "wired" world, development and dissemination of clinical practice guidelines and other knowledge support strategies, and the role of diverse stakeholders in the generation and adoption of evidence are presented.