Parallelization and Algorithmic Enhancements of High Resolution IRAS Image Construction

NASA Technical Reports Server (NTRS)

Cao, Yu; Prince, Thomas A.; Tereby, Susan; Beichman, Charles A.

1996-01-01

The Infrared Astronomical Satellite caried out a nearly complete survey of the infrared sky, and the survey data are important for the study of many astrophysical phenomena. However, many data sets at other wavelengths have higher resolutions than that of the co-added IRAS maps, and high resolution IRAS images are strongly desired both for their own information content and their usefulness in correlation. The HIRES program was developed by the Infrared Processing and Analysis Center (IPAC) to produce high resolution (approx. 1') images from IRAS data using the Maximum Correlation Method (MCM). We describe the port of HIRES to the Intel Paragon, a massively parallel supercomputer, other software developments for mass production of HIRES images, and the IRAS Galaxy Atlas, a project to map the Galactic plane at 60 and 100(micro)m.

The Correlation among Neural Dynamic Processing of Conflict Control, Testosterone and Cortisol Levels in 10-Year-Old Children.

PubMed

Shangguan, Fangfang; Liu, Tongran; Liu, Xiuying; Shi, Jiannong

2017-01-01

Cognitive control is related to goal-directed self-regulation abilities, which is fundamental for human development. Conflict control includes the neural processes of conflict monitoring and conflict resolution. Testosterone and cortisol are essential hormones for the development of cognitive functions. However, there are no studies that have investigated the correlation of these two hormones with conflict control in preadolescents. In this study, we aimed to explore whether testosterone, cortisol, and testosterone/cortisol ratio worked differently for preadolescent's conflict control processes in varied conflict control tasks. Thirty-two 10-year-old children (16 boys and 16 girls) were enrolled. They were instructed to accomplish three conflict control tasks with different conflict dimensions, including the Flanker, Simon, and Stroop tasks, and electrophysiological signals were recorded. Salivary samples were collected from each child. The testosterone and cortisol levels were determined by enzyme-linked immunosorbent assay. The electrophysiological results showed that the incongruent trials induced greater N2/N450 and P3/SP responses than the congruent trials during neural processes of conflict monitoring and conflict resolution in the Flanker and Stroop tasks. The hormonal findings showed that (1) the testosterone/cortisol ratio was correlated with conflict control accuracy and conflict resolution in the Flanker task; (2) the testosterone level was associated with conflict control performance and neural processing of conflict resolution in the Stroop task; (3) the cortisol level was correlated with conflict control performance and neural processing of conflict monitoring in the Simon task. In conclusion, in 10-year-old children, the fewer processes a task needs, the more likely there is an association between the T/C ratios and the behavioral and brain response, and the dual-hormone effects on conflict resolution may be testosterone-driven in the Stroop and Flanker tasks.

Micropillar displacements by cell traction forces are mechanically correlated with nuclear dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Qingsen; Makhija, Ekta; Hameed, F.M.

2015-05-29

Cells sense physical cues at the level of focal adhesions and transduce them to the nucleus by biochemical and mechanical pathways. While the molecular intermediates in the mechanical links have been well studied, their dynamic coupling is poorly understood. In this study, fibroblast cells were adhered to micropillar arrays to probe correlations in the physical coupling between focal adhesions and nucleus. For this, we used novel imaging setup to simultaneously visualize micropillar deflections and EGFP labeled chromatin structure at high spatial and temporal resolution. We observed that micropillar deflections, depending on their relative positions, were positively or negatively correlated tomore » nuclear and heterochromatin movements. Our results measuring the time scales between micropillar deflections and nucleus centroid displacement are suggestive of a strong elastic coupling that mediates differential force transmission to the nucleus. - Highlights: • Correlation between focal adhesions and nucleus studied using novel imaging setup. • Micropillar and nuclear displacements were measured at high resolution. • Correlation timescales show strong elastic coupling between cell edge and nucleus.« less

Automatic Sub-Pixel Co-Registration of LandSat-8 OLI and Sentinel-2A MSI Images Using Phase Correlation and Machine Learning Based Mapping

NASA Technical Reports Server (NTRS)

Skakun, Sergii; Roger, Jean-Claude; Vermote, Eric F.; Masek, Jeffrey G.; Justice, Christopher O.

2017-01-01

This study investigates misregistration issues between Landsat-8/OLI and Sentinel-2A/MSI at 30 m resolution, and between multi-temporal Sentinel-2A images at 10 m resolution using a phase correlation approach and multiple transformation functions. Co-registration of 45 Landsat-8 to Sentinel-2A pairs and 37 Sentinel-2A to Sentinel-2A pairs were analyzed. Phase correlation proved to be a robust approach that allowed us to identify hundreds and thousands of control points on images acquired more than 100 days apart. Overall, misregistration of up to 1.6 pixels at 30 m resolution between Landsat-8 and Sentinel-2A images, and 1.2 pixels and 2.8 pixels at 10 m resolution between multi-temporal Sentinel-2A images from the same and different orbits, respectively, were observed. The non-linear Random Forest regression used for constructing the mapping function showed best results in terms of root mean square error (RMSE), yielding an average RMSE error of 0.07+/-0.02 pixels at 30 m resolution, and 0.09+/-0.05 and 0.15+/-0.06 pixels at 10 m resolution for the same and adjacent Sentinel-2A orbits, respectively, for multiple tiles and multiple conditions. A simpler 1st order polynomial function (affine transformation) yielded RMSE of 0.08+/-0.02 pixels at 30 m resolution and 0.12+/-0.06 (same Sentinel-2A orbits) and 0.20+/-0.09 (adjacent orbits) pixels at 10 m resolution.

Rapid evolution of the intersexual genetic correlation for fitness in Drosophila melanogaster.

PubMed

Collet, Julie M; Fuentes, Sara; Hesketh, Jack; Hill, Mark S; Innocenti, Paolo; Morrow, Edward H; Fowler, Kevin; Reuter, Max

2016-04-01

Sexual antagonism (SA) arises when male and female phenotypes are under opposing selection, yet genetically correlated. Until resolved, antagonism limits evolution toward optimal sex-specific phenotypes. Despite its importance for sex-specific adaptation and existing theory, the dynamics of SA resolution are not well understood empirically. Here, we present data from Drosophila melanogaster, compatible with a resolution of SA. We compared two independent replicates of the "LHM " population in which SA had previously been described. Both had been maintained under identical, controlled conditions, and separated for around 200 generations. Although heritabilities of male and female fitness were similar, the intersexual genetic correlation differed significantly, being negative in one replicate (indicating SA) but close to zero in the other. Using population sequencing, we show that phenotypic differences were associated with population divergence in allele frequencies at nonrandom loci across the genome. Large frequency changes were more prevalent in the population without SA and were enriched at loci mapping to genes previously shown to have sexually antagonistic relationships between expression and fitness. Our data suggest that rapid evolution toward SA resolution has occurred in one of the populations and open avenues toward studying the genetics of SA and its resolution. © 2016 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution.

Aggression, conflict resolution, popularity, and attitude to school in Russian adolescents.

PubMed

Butovskaya, Marina L; Timentschik, Vera M; Burkova, Valentina N

2007-01-01

The objective of the present study was to examine the effects of aggression and conflict-managing skills on popularity and attitude to school in Russian adolescents. Three types of aggression (physical, verbal, and indirect), constructive conflict resolution, third-party intervention, withdrawal, and victimization were examined using the Peer-Estimated Conflict Behavior (PECOBE) inventory [Bjorkquist and Osterman, 1998]. Also, all respondents rated peer and self-popularity with same-sex classmates and personal attitude to school. The sample consisted of 212 Russian adolescents (101 boys, 111 girls) aged between 11 and 15 years. The findings attest to significant sex differences in aggression and conflict resolution patterns. Boys scored higher on physical and verbal aggression, and girls on indirect aggression. Girls were socially more skillful than boys in the use of peaceful means of conflict resolution (they scored higher on constructive conflict resolution and third-party intervention). The attributional discrepancy index (ADI) scores were negative for all three types of aggression in both sexes. Verbal aggression is apparently more condemned in boys than in girls. ADI scores were positive for constructive conflict resolution and third-party intervention in both genders, being higher in boys. In girls, verbal aggression was positively correlated with popularity. In both sexes, popularity showed a positive correlation with constructive conflict resolution and third-party intervention, and a negative correlation with withdrawal and victimization. Boys who liked school were popular with same-sex peers and scored higher on constructive conflict resolution. Girls who liked school were less aggressive according to peer rating. They also rated higher on conflict resolution and third-party intervention. Physical aggression was related to age. The results are discussed in a cross-cultural perspective. Copyright 2007 Wiley-Liss, Inc.

Comparing spatial tuning curves, spectral ripple resolution, and speech perception in cochlear implant users.

PubMed

Anderson, Elizabeth S; Nelson, David A; Kreft, Heather; Nelson, Peggy B; Oxenham, Andrew J

2011-07-01

Spectral ripple discrimination thresholds were measured in 15 cochlear-implant users with broadband (350-5600 Hz) and octave-band noise stimuli. The results were compared with spatial tuning curve (STC) bandwidths previously obtained from the same subjects. Spatial tuning curve bandwidths did not correlate significantly with broadband spectral ripple discrimination thresholds but did correlate significantly with ripple discrimination thresholds when the rippled noise was confined to an octave-wide passband, centered on the STC's probe electrode frequency allocation. Ripple discrimination thresholds were also measured for octave-band stimuli in four contiguous octaves, with center frequencies from 500 Hz to 4000 Hz. Substantial variations in thresholds with center frequency were found in individuals, but no general trends of increasing or decreasing resolution from apex to base were observed in the pooled data. Neither ripple nor STC measures correlated consistently with speech measures in noise and quiet in the sample of subjects in this study. Overall, the results suggest that spectral ripple discrimination measures provide a reasonable measure of spectral resolution that correlates well with more direct, but more time-consuming, measures of spectral resolution, but that such measures do not always provide a clear and robust predictor of performance in speech perception tasks. © 2011 Acoustical Society of America

Comparing spatial tuning curves, spectral ripple resolution, and speech perception in cochlear implant users

PubMed Central

Anderson, Elizabeth S.; Nelson, David A.; Kreft, Heather; Nelson, Peggy B.; Oxenham, Andrew J.

2011-01-01

Spectral ripple discrimination thresholds were measured in 15 cochlear-implant users with broadband (350–5600 Hz) and octave-band noise stimuli. The results were compared with spatial tuning curve (STC) bandwidths previously obtained from the same subjects. Spatial tuning curve bandwidths did not correlate significantly with broadband spectral ripple discrimination thresholds but did correlate significantly with ripple discrimination thresholds when the rippled noise was confined to an octave-wide passband, centered on the STC’s probe electrode frequency allocation. Ripple discrimination thresholds were also measured for octave-band stimuli in four contiguous octaves, with center frequencies from 500 Hz to 4000 Hz. Substantial variations in thresholds with center frequency were found in individuals, but no general trends of increasing or decreasing resolution from apex to base were observed in the pooled data. Neither ripple nor STC measures correlated consistently with speech measures in noise and quiet in the sample of subjects in this study. Overall, the results suggest that spectral ripple discrimination measures provide a reasonable measure of spectral resolution that correlates well with more direct, but more time-consuming, measures of spectral resolution, but that such measures do not always provide a clear and robust predictor of performance in speech perception tasks. PMID:21786905

Energy correlations of photon pairs generated by a silicon microring resonator probed by Stimulated Four Wave Mixing.

PubMed

Grassani, Davide; Simbula, Angelica; Pirotta, Stefano; Galli, Matteo; Menotti, Matteo; Harris, Nicholas C; Baehr-Jones, Tom; Hochberg, Michael; Galland, Christophe; Liscidini, Marco; Bajoni, Daniele

2016-04-01

Compact silicon integrated devices, such as micro-ring resonators, have recently been demonstrated as efficient sources of quantum correlated photon pairs. The mass production of integrated devices demands the implementation of fast and reliable techniques to monitor the device performances. In the case of time-energy correlations, this is particularly challenging, as it requires high spectral resolution that is not currently achievable in coincidence measurements. Here we reconstruct the joint spectral density of photons pairs generated by spontaneous four-wave mixing in a silicon ring resonator by studying the corresponding stimulated process, namely stimulated four wave mixing. We show that this approach, featuring high spectral resolution and short measurement times, allows one to discriminate between nearly-uncorrelated and highly-correlated photon pairs.

Importance of ocean mesoscale variability for air-sea interactions in the Gulf of Mexico

NASA Astrophysics Data System (ADS)

Putrasahan, D. A.; Kamenkovich, I.; Le Hénaff, M.; Kirtman, B. P.

2017-06-01

Mesoscale variability of currents in the Gulf of Mexico (GoM) can affect oceanic heat advection and air-sea heat exchanges, which can influence climate extremes over North America. This study is aimed at understanding the influence of the oceanic mesoscale variability on the lower atmosphere and air-sea heat exchanges. The study contrasts global climate model (GCM) with 0.1° ocean resolution (high resolution; HR) with its low-resolution counterpart (1° ocean resolution with the same 0.5° atmosphere resolution; LR). The LR simulation is relevant to current generation of GCMs that are still unable to resolve the oceanic mesoscale. Similar to observations, HR exhibits positive correlation between sea surface temperature (SST) and surface turbulent heat flux anomalies, while LR has negative correlation. For HR, we decompose lateral advective heat fluxes in the upper ocean into mean (slowly varying) and mesoscale-eddy (fast fluctuations) components. We find that the eddy flux divergence/convergence dominates the lateral advection and correlates well with the SST anomalies and air-sea latent heat exchanges. This result suggests that oceanic mesoscale advection supports warm SST anomalies that in turn feed surface heat flux. We identify anticyclonic warm-core circulation patterns (associated Loop Current and rings) which have an average diameter of 350 km. These warm anomalies are sustained by eddy heat flux convergence at submonthly time scales and have an identifiable imprint on surface turbulent heat flux, atmospheric circulation, and convective precipitation in the northwest portion of an averaged anticyclone.

Design of an Eye Limiting Resolution Visual System Using Commercial-Off-the-Shelf Equipment

NASA Technical Reports Server (NTRS)

Sweet, Barbara T.; Giovannetti, Dean P.

2008-01-01

A feasibility study was conducted to determine if a flight simulator with an eye-limiting resolution out-the-window (OTW) visual system could be built using commercial off-the-shelf (COTS) technology and used to evaluate the visual performance of Air Force pilots in an operations context. Results of this study demonstrate that an eye limiting OTW visual system can be built using COTS technology. Further, a series of operationally-based tasks linked to clinical vision tests can be used within the synthetic environment to demonstrate a correlation and quantify the level of correlation between vision and operational aviation performance.

Correlative Stochastic Optical Reconstruction Microscopy and Electron Microscopy

PubMed Central

Kim, Doory; Deerinck, Thomas J.; Sigal, Yaron M.; Babcock, Hazen P.; Ellisman, Mark H.; Zhuang, Xiaowei

2015-01-01

Correlative fluorescence light microscopy and electron microscopy allows the imaging of spatial distributions of specific biomolecules in the context of cellular ultrastructure. Recent development of super-resolution fluorescence microscopy allows the location of molecules to be determined with nanometer-scale spatial resolution. However, correlative super-resolution fluorescence microscopy and electron microscopy (EM) still remains challenging because the optimal specimen preparation and imaging conditions for super-resolution fluorescence microscopy and EM are often not compatible. Here, we have developed several experiment protocols for correlative stochastic optical reconstruction microscopy (STORM) and EM methods, both for un-embedded samples by applying EM-specific sample preparations after STORM imaging and for embedded and sectioned samples by optimizing the fluorescence under EM fixation, staining and embedding conditions. We demonstrated these methods using a variety of cellular targets. PMID:25874453

Extraction of temporal information in functional MRI

NASA Astrophysics Data System (ADS)

Singh, M.; Sungkarat, W.; Jeong, Jeong-Won; Zhou, Yongxia

2002-10-01

The temporal resolution of functional MRI (fMRI) is limited by the shape of the haemodynamic response function (hrf) and the vascular architecture underlying the activated regions. Typically, the temporal resolution of fMRI is on the order of 1 s. We have developed a new data processing approach to extract temporal information on a pixel-by-pixel basis at the level of 100 ms from fMRI data. Instead of correlating or fitting the time-course of each pixel to a single reference function, which is the common practice in fMRI, we correlate each pixel's time-course to a series of reference functions that are shifted with respect to each other by 100 ms. The reference function yielding the highest correlation coefficient for a pixel is then used as a time marker for that pixel. A Monte Carlo simulation and experimental study of this approach were performed to estimate the temporal resolution as a function of signal-to-noise ratio (SNR) in the time-course of a pixel. Assuming a known and stationary hrf, the simulation and experimental studies suggest a lower limit in the temporal resolution of approximately 100 ms at an SNR of 3. The multireference function approach was also applied to extract timing information from an event-related motor movement study where the subjects flexed a finger on cue. The event was repeated 19 times with the event's presentation staggered to yield an approximately 100-ms temporal sampling of the haemodynamic response over the entire presentation cycle. The timing differences among different regions of the brain activated by the motor task were clearly visualized and quantified by this method. The results suggest that it is possible to achieve a temporal resolution of /spl sim/200 ms in practice with this approach.

Live CLEM imaging to analyze nuclear structures at high resolution.

PubMed

Haraguchi, Tokuko; Osakada, Hiroko; Koujin, Takako

2015-01-01

Fluorescence microscopy (FM) and electron microscopy (EM) are powerful tools for observing molecular components in cells. FM can provide temporal information about cellular proteins and structures in living cells. EM provides nanometer resolution images of cellular structures in fixed cells. We have combined FM and EM to develop a new method of correlative light and electron microscopy (CLEM), called "Live CLEM." In this method, the dynamic behavior of specific molecules of interest is first observed in living cells using fluorescence microscopy (FM) and then cellular structures in the same cell are observed using electron microscopy (EM). Following image acquisition, FM and EM images are compared to enable the fluorescent images to be correlated with the high-resolution images of cellular structures obtained using EM. As this method enables analysis of dynamic events involving specific molecules of interest in the context of specific cellular structures at high resolution, it is useful for the study of nuclear structures including nuclear bodies. Here we describe Live CLEM that can be applied to the study of nuclear structures in mammalian cells.

Towards Understanding the Contribution of Waterbodies to the Methane Emissions of a Permafrost Landscape on a Regional Scale - A Case Study from the Mackenzie Delta, Canada

NASA Astrophysics Data System (ADS)

Kohnert, K.; Juhls, B.; Muster, S.; Antonova, S.; Serafimovich, A.; Sachs, T.

2017-12-01

Waterbodies in the arctic permafrost zone are considered a major source of the greenhouse gas methane (CH4). However, the spatio-temporal variability of CH4 fluxes from waterbodies complicates spatial extrapolation of CH4 measurements at individual waterbodies. Therefore, the contribution of CH4 emissions from different waterbody types to the CH4 budget of the arctic permafrost zone has not yet been well constrained. To approach this problem, our study aimed i) at understanding if there are correlations between waterbodies and CH4 fluxes on a larger spatial extent containing several waterbodies and ii) at quantifying the influence of the spatial resolution of CH4 flux data on potential relations. Our two study areas of 1000 km² each are located in the northern and central part of the Mackenzie Delta, arctic Canada. We classified the waterbodies using maps from the circum-arctic Permafrost Region Pond and Lake Database (PeRL) based on TerraSAR-X data with a spatial resolution of 2.5 m x 2.5 m. We used the backscatter signals of Sentinel-1 data to determine whether or not waterbodies were freezing to the bottom to divide them into the two classes "deep" (> 2 m depth) and "shallow" (< 2 m depth). The CH4 flux map with a spatial resolution of 100 m x 100 m was calculated from data derived via the eddy-covariance technique from two aircraft campaigns in July 2012 and 2013. We coarsened the resolution of the CH4 flux map manually, to analyze if different spatial resolutions of CH4 flux data have an effect on the relation between waterbody characteristics (coverage, number, depth, size) and CH4 flux. We found that in both study areas, there was no correlation at any spatial resolution between the area fraction covered with water and the CH4 flux at a significance level of α = 0.05. We did not find consistent correlations or patterns between the number, size or depth of waterbodies and the CH4 flux in the two study areas. While there was no significant correlation in the central study area, in the northern study area a higher number of small or shallow waterbodies slightly increased the CH4 flux, whereas deep waterbodies decreased the CH4 flux. Our results indicate that waterbodies in permafrost landscapes do not necessarily act as significant CH4 emission hotspots on a regional scale containing both waterbodies and wetlands.

Rapid evolution of the intersexual genetic correlation for fitness in Drosophila melanogaster

PubMed Central

Collet, Julie M.; Fuentes, Sara; Hesketh, Jack; Hill, Mark S.; Innocenti, Paolo; Morrow, Edward H.; Fowler, Kevin; Reuter, Max

2016-01-01

Sexual antagonism (SA) arises when male and female phenotypes are under opposing selection, yet genetically correlated. Until resolved, antagonism limits evolution toward optimal sex‐specific phenotypes. Despite its importance for sex‐specific adaptation and existing theory, the dynamics of SA resolution are not well understood empirically. Here, we present data from Drosophila melanogaster, compatible with a resolution of SA. We compared two independent replicates of the “LHM” population in which SA had previously been described. Both had been maintained under identical, controlled conditions, and separated for around 200 generations. Although heritabilities of male and female fitness were similar, the intersexual genetic correlation differed significantly, being negative in one replicate (indicating SA) but close to zero in the other. Using population sequencing, we show that phenotypic differences were associated with population divergence in allele frequencies at nonrandom loci across the genome. Large frequency changes were more prevalent in the population without SA and were enriched at loci mapping to genes previously shown to have sexually antagonistic relationships between expression and fitness. Our data suggest that rapid evolution toward SA resolution has occurred in one of the populations and open avenues toward studying the genetics of SA and its resolution. PMID:27077679

From degree-correlated to payoff-correlated activity for an optimal resolution of social dilemmas

NASA Astrophysics Data System (ADS)

Aleta, Alberto; Meloni, Sandro; Perc, Matjaž; Moreno, Yamir

2016-12-01

An active participation of players in evolutionary games depends on several factors, ranging from personal stakes to the properties of the interaction network. Diverse activity patterns thus have to be taken into account when studying the evolution of cooperation in social dilemmas. Here we study the weak prisoner's dilemma game, where the activity of each player is determined in a probabilistic manner either by its degree or by its payoff. While degree-correlated activity introduces cascading failures of cooperation that are particularly severe on scale-free networks with frequently inactive hubs, payoff-correlated activity provides a more nuanced activity profile, which ultimately hinders systemic breakdowns of cooperation. To determine optimal conditions for the evolution of cooperation, we introduce an exponential decay to payoff-correlated activity that determines how fast the activity of a player returns to its default state. We show that there exists an intermediate decay rate at which the resolution of the social dilemma is optimal. This can be explained by the emerging activity patterns of players, where the inactivity of hubs is compensated effectively by the increased activity of average-degree players, who through their collective influence in the network sustain a higher level of cooperation. The sudden drops in the fraction of cooperators observed with degree-correlated activity therefore vanish, and so does the need for the lengthy spatiotemporal reorganization of compact cooperative clusters. The absence of such asymmetric dynamic instabilities thus leads to an optimal resolution of social dilemmas, especially when the conditions for the evolution of cooperation are strongly adverse.

The ALMA correlator

NASA Astrophysics Data System (ADS)

Escoffier, R. P.; Comoretto, G.; Webber, J. C.; Baudry, A.; Broadwell, C. M.; Greenberg, J. H.; Treacy, R. R.; Cais, P.; Quertier, B.; Camino, P.; Bos, A.; Gunst, A. W.

2007-02-01

Aims: The Atacama Large Millimeter Array (ALMA) is an international astronomy facility to be used for detecting and imaging all types of astronomical sources at millimeter and submillimeter wavelengths at a 5000-m elevation site in the Atacama Desert of Chile. Our main aims are: describe the correlator sub-system which is that part of the ALMA system that combines the signal from up to 64 remote individual radio antennas and forms them into a single instrument; emphasize the high spectral resolution and the configuration flexibility available with the ALMA correlator. Methods: The main digital signal processing features and a block diagram of the correlator being constructed for the ALMA radio astronomy observatory are presented. Tables of observing modes and spectral resolutions offered by the correlator system are given together with some examples of multi-resolution spectral modes. Results: The correlator is delivered by quadrants and the first quadrant is being tested while most of the other printed circuit cards required by the system have been produced. In its final version the ALMA correlator will process the outputs of up to 64 antennas using an instantaneous bandwidth of 8 GHz in each of two polarizations per antenna. In the frequency division mode, unrivalled spectral flexibility together with very high resolution (3.8 kHz) and up to 8192 spectral points are achieved. In the time division mode high time resolution is available with minimum data dump rates of 16 ms for all cross-products.

Feasibility of high temporal resolution breast DCE-MRI using compressed sensing theory.

PubMed

Wang, Haoyu; Miao, Yanwei; Zhou, Kun; Yu, Yanming; Bao, Shanglian; He, Qiang; Dai, Yongming; Xuan, Stephanie Y; Tarabishy, Bisher; Ye, Yongquan; Hu, Jiani

2010-09-01

To investigate the feasibility of high temporal resolution breast DCE-MRI using compressed sensing theory. Two experiments were designed to investigate the feasibility of using reference image based compressed sensing (RICS) technique in DCE-MRI of the breast. The first experiment examined the capability of RICS to faithfully reconstruct uptake curves using undersampled data sets extracted from fully sampled clinical breast DCE-MRI data. An average approach and an approach using motion estimation and motion compensation (ME/MC) were implemented to obtain reference images and to evaluate their efficacy in reducing motion related effects. The second experiment, an in vitro phantom study, tested the feasibility of RICS for improving temporal resolution without degrading the spatial resolution. For the uptake-curve reconstruction experiment, there was a high correlation between uptake curves reconstructed from fully sampled data by Fourier transform and from undersampled data by RICS, indicating high similarity between them. The mean Pearson correlation coefficients for RICS with the ME/MC approach and RICS with the average approach were 0.977 +/- 0.023 and 0.953 +/- 0.031, respectively. The comparisons of final reconstruction results between RICS with the average approach and RICS with the ME/MC approach suggested that the latter was superior to the former in reducing motion related effects. For the in vitro experiment, compared to the fully sampled method, RICS improved the temporal resolution by an acceleration factor of 10 without degrading the spatial resolution. The preliminary study demonstrates the feasibility of RICS for faithfully reconstructing uptake curves and improving temporal resolution of breast DCE-MRI without degrading the spatial resolution.

Geostatistics and the representative elementary volume of gamma ray tomography attenuation in rocks cores

USGS Publications Warehouse

Vogel, J.R.; Brown, G.O.

2003-01-01

Semivariograms of samples of Culebra Dolomite have been determined at two different resolutions for gamma ray computed tomography images. By fitting models to semivariograms, small-scale and large-scale correlation lengths are determined for four samples. Different semivariogram parameters were found for adjacent cores at both resolutions. Relative elementary volume (REV) concepts are related to the stationarity of the sample. A scale disparity factor is defined and is used to determine sample size required for ergodic stationarity with a specified correlation length. This allows for comparison of geostatistical measures and representative elementary volumes. The modifiable areal unit problem is also addressed and used to determine resolution effects on correlation lengths. By changing resolution, a range of correlation lengths can be determined for the same sample. Comparison of voxel volume to the best-fit model correlation length of a single sample at different resolutions reveals a linear scaling effect. Using this relationship, the range of the point value semivariogram is determined. This is the range approached as the voxel size goes to zero. Finally, these results are compared to the regularization theory of point variables for borehole cores and are found to be a better fit for predicting the volume-averaged range.

VECC array for Nuclear fast Timing and angUlar corRElation studies (VENTURE)

NASA Astrophysics Data System (ADS)

Alam, S. S.; Bhattacharjee, T.; Banerjee, D.; Saha, A.; Pandit, Deepak; Mondal, D.; Mukhopadhyay, S.; Pal, Surajit; Bhaskar, P.; Das, S. K.; Banerjee, S. R.

2017-12-01

The VECC array for Nuclear fast Timing and angUlar corRElation studies (VENTURE) has been developed using several fast Cerium-Bromide (CeBr3) scintillators coupled to Hamamatsu R9779 Photomultiplier tubes. The CeBr3 detector has been characterised for the spectroscopic properties like energy response, energy resolution, timing resolution and detection efficiency. The response and efficiency of the detector have been compared with the results obtained from a Monte Carlo simulation with GEANT3 package. A time resolution of 144(1) ps and 109(1) ps was obtained for a single detector using 622-512 keV and 1173-1332 keV cascades respectively. The Generalised Centroid Difference (GCD) method has been employed with CeBr3 detectors by measuring the level lifetimes for the 511.9 keV level of 106Pd and the 160.6 and 383.8 keV levels of 133Cs. The angular correlation measurement was performed for the 1173-1332 keV cascade in 60Ni and the 228-49 keV cascade of 132I nucleus, populated from the decay of 132Te produced via 238U(α, f) reaction.

Evaluation of the relation between evapotranspiration and normalized difference vegetation index for downscaling the simplified surface energy balance model

USGS Publications Warehouse

Haynes, Jonathan V.; Senay, Gabriel B.

2012-01-01

The Simplified Surface Energy Balance (SSEB) model uses satellite imagery to estimate actual evapotranspiration (ETa) at 1-kilometer resolution. SSEB ETa is useful for estimating irrigation water use; however, resolution limitations restrict its use to regional scale applications. The U.S. Geological Survey investigated the downscaling potential of SSEB ETa from 1 kilometer to 250 meters by correlating ETa with the Normalized Difference Vegetation Index (NDVI) from the Moderate Resolution Imaging Spectroradiometer instrument (MODIS). Correlations were studied in three arid to semiarid irrigated landscapes of the Western United States (Escalante Valley near Enterprise, Utah; Palo Verde Valley near Blythe, California; and part of the Columbia Plateau near Quincy, Washington) during several periods from 2002 to 2008. Irrigation season ETa-NDVI correlations were lower than expected, ranging from R2 of 0.20 to 0.61 because of an eastward 2–3 kilometer shift in ETadata. The shift is due to a similar shift identified in the land-surface temperature (LST) data from the MODIS Terra satellite, which is used in the SSEB model. Further study is needed to delineate the Terra LST shift, its effect on SSEB ETa, and the relation between ETa and NDVI.

Dithering Digital Ripple Correlation Control for Photovoltaic Maximum Power Point Tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barth, C; Pilawa-Podgurski, RCN

This study demonstrates a new method for rapid and precise maximum power point tracking in photovoltaic (PV) applications using dithered PWM control. Constraints imposed by efficiency, cost, and component size limit the available PWM resolution of a power converter, and may in turn limit the MPP tracking efficiency of the PV system. In these scenarios, PWM dithering can be used to improve average PWM resolution. In this study, we present a control technique that uses ripple correlation control (RCC) on the dithering ripple, thereby achieving simultaneous fast tracking speed and high tracking accuracy. Moreover, the proposed method solves some ofmore » the practical challenges that have to date limited the effectiveness of RCC in solar PV applications. We present a theoretical derivation of the principles behind dithering digital ripple correlation control, as well as experimental results that show excellent tracking speed and accuracy with basic hardware requirements.« less

The Correlation among Neural Dynamic Processing of Conflict Control, Testosterone and Cortisol Levels in 10-Year-Old Children

PubMed Central

Shangguan, Fangfang; Liu, Tongran; Liu, Xiuying; Shi, Jiannong

2017-01-01

Cognitive control is related to goal-directed self-regulation abilities, which is fundamental for human development. Conflict control includes the neural processes of conflict monitoring and conflict resolution. Testosterone and cortisol are essential hormones for the development of cognitive functions. However, there are no studies that have investigated the correlation of these two hormones with conflict control in preadolescents. In this study, we aimed to explore whether testosterone, cortisol, and testosterone/cortisol ratio worked differently for preadolescent’s conflict control processes in varied conflict control tasks. Thirty-two 10-year-old children (16 boys and 16 girls) were enrolled. They were instructed to accomplish three conflict control tasks with different conflict dimensions, including the Flanker, Simon, and Stroop tasks, and electrophysiological signals were recorded. Salivary samples were collected from each child. The testosterone and cortisol levels were determined by enzyme-linked immunosorbent assay. The electrophysiological results showed that the incongruent trials induced greater N2/N450 and P3/SP responses than the congruent trials during neural processes of conflict monitoring and conflict resolution in the Flanker and Stroop tasks. The hormonal findings showed that (1) the testosterone/cortisol ratio was correlated with conflict control accuracy and conflict resolution in the Flanker task; (2) the testosterone level was associated with conflict control performance and neural processing of conflict resolution in the Stroop task; (3) the cortisol level was correlated with conflict control performance and neural processing of conflict monitoring in the Simon task. In conclusion, in 10-year-old children, the fewer processes a task needs, the more likely there is an association between the T/C ratios and the behavioral and brain response, and the dual-hormone effects on conflict resolution may be testosterone-driven in the Stroop and Flanker tasks. PMID:28690571

Noise correlation in CBCT projection data and its application for noise reduction in low-dose CBCT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Hua; Ouyang, Luo; Wang, Jing, E-mail: jhma@smu.edu.cn, E-mail: jing.wang@utsouthwestern.edu

2014-03-15

Purpose: To study the noise correlation properties of cone-beam CT (CBCT) projection data and to incorporate the noise correlation information to a statistics-based projection restoration algorithm for noise reduction in low-dose CBCT. Methods: In this study, the authors systematically investigated the noise correlation properties among detector bins of CBCT projection data by analyzing repeated projection measurements. The measurements were performed on a TrueBeam onboard CBCT imaging system with a 4030CB flat panel detector. An anthropomorphic male pelvis phantom was used to acquire 500 repeated projection data at six different dose levels from 0.1 to 1.6 mAs per projection at threemore » fixed angles. To minimize the influence of the lag effect, lag correction was performed on the consecutively acquired projection data. The noise correlation coefficient between detector bin pairs was calculated from the corrected projection data. The noise correlation among CBCT projection data was then incorporated into the covariance matrix of the penalized weighted least-squares (PWLS) criterion for noise reduction of low-dose CBCT. Results: The analyses of the repeated measurements show that noise correlation coefficients are nonzero between the nearest neighboring bins of CBCT projection data. The average noise correlation coefficients for the first- and second-order neighbors are 0.20 and 0.06, respectively. The noise correlation coefficients are independent of the dose level. Reconstruction of the pelvis phantom shows that the PWLS criterion with consideration of noise correlation (PWLS-Cor) results in a lower noise level as compared to the PWLS criterion without considering the noise correlation (PWLS-Dia) at the matched resolution. At the 2.0 mm resolution level in the axial-plane noise resolution tradeoff analysis, the noise level of the PWLS-Cor reconstruction is 6.3% lower than that of the PWLS-Dia reconstruction. Conclusions: Noise is correlated among nearest neighboring detector bins of CBCT projection data. An accurate noise model of CBCT projection data can improve the performance of the statistics-based projection restoration algorithm for low-dose CBCT.« less

The correlation of symptoms, pulmonary function tests and exercise testing with high-resolution computed tomography in patients with idiopathic interstitial pneumonia in a tertiary care hospital in South India.

PubMed

Isaac, Barney Thomas Jesudason; Thangakunam, Balamugesh; Cherian, Rekha A; Christopher, Devasahayam Jesudas

2015-01-01

For the follow-up of patients with idiopathic interstitial pneumonias (IIP), it is unclear which parameters of pulmonary function tests (PFT) and exercise testing would correlate best with high-resolution computed tomography (HRCT).. To find out the correlation of symptom scores, PFTs and exercise testing with HRCT scoring in patients diagnosed as idiopathic interstitial pneumonia. Cross-sectional study done in pulmonary medicine outpatients department of a tertiary care hospital in South India. Consecutive patients who were diagnosed as IIP by a standard algorithm were included into the study. Cough and dyspnea were graded for severity and duration. Pulmonary function tests and exercise testing parameters were noted. HRCT was scored based on an alveolar score, an interstitial score and a total score. The HRCT was correlated with each of the clinical and physiologic parameters. Pearson's/Spearman's correlation coefficient was used for the correlation of symptoms and parameters of ABG, PFT and 6MWT with the HRCT scores. A total of 94 patients were included in the study. Cough and dyspnea severity (r = 0.336 and 0.299), FVC (r = -0.48), TLC (r = -0.439) and DLCO and distance saturation product (DSP) (r = -0.368) and lowest saturation (r = -0.324) had significant correlation with total HRCT score. Among these, DLCO, particularly DLCO corrected % of predicted, correlated best with HRCT score (r = -0.721).. Symptoms, PFT and exercise testing had good correlation with HRCT. DLCO corrected % of predicted correlated best with HRCT.

Damage extraction of buildings in the 2015 Gorkha, Nepal earthquake from high-resolution SAR data

NASA Astrophysics Data System (ADS)

Yamazaki, Fumio; Bahri, Rendy; Liu, Wen; Sasagawa, Tadashi

2016-05-01

Satellite remote sensing is recognized as one of the effective tools for detecting and monitoring affected areas due to natural disasters. Since SAR sensors can capture images not only at daytime but also at nighttime and under cloud-cover conditions, they are especially useful at an emergency response period. In this study, multi-temporal high-resolution TerraSAR-X images were used for damage inspection of the Kathmandu area, which was severely affected by the April 25, 2015 Gorkha Earthquake. The SAR images obtained before and after the earthquake were utilized for calculating the difference and correlation coefficient of backscatter. The affected areas were identified by high values of the absolute difference and low values of the correlation coefficient. The post-event high-resolution optical satellite images were employed as ground truth data to verify our results. Although it was difficult to estimate the damage levels for individual buildings, the high resolution SAR images could illustrate their capability in detecting collapsed buildings at emergency response times.

Effects of Scan Resolutions and Element Sizes on Bovine Vertebral Mechanical Parameters from Quantitative Computed Tomography-Based Finite Element Analysis

PubMed Central

Zhang, Meng; Gao, Jiazi; Huang, Xu; Zhang, Min; Liu, Bei

2017-01-01

Quantitative computed tomography-based finite element analysis (QCT/FEA) has been developed to predict vertebral strength. However, QCT/FEA models may be different with scan resolutions and element sizes. The aim of this study was to explore the effects of scan resolutions and element sizes on QCT/FEA outcomes. Nine bovine vertebral bodies were scanned using the clinical CT scanner and reconstructed from datasets with the two-slice thickness, that is, 0.6 mm (PA resolution) and 1 mm (PB resolution). There were significantly linear correlations between the predicted and measured principal strains (R2 > 0.7, P < 0.0001), and the predicted vertebral strength and stiffness were modestly correlated with the experimental values (R2 > 0.6, P < 0.05). Two different resolutions and six different element sizes were combined in pairs, and finite element (FE) models of bovine vertebral cancellous bones in the 12 cases were obtained. It showed that the mechanical parameters of FE models with the PB resolution were similar to those with the PA resolution. The computational accuracy of FE models with the element sizes of 0.41 × 0.41 × 0.6 mm3 and 0.41 × 0.41 × 1 mm3 was higher by comparing the apparent elastic modulus and yield strength. Therefore, scan resolution and element size should be chosen optimally to improve the accuracy of QCT/FEA. PMID:29065624

Segmental and Suprasegmental Perception in Children Using Hearing Aids.

PubMed

Wenrich, Kaitlyn A; Davidson, Lisa S; Uchanski, Rosalie M

Suprasegmental perception (perception of stress, intonation, "how something is said" and "who says it") and segmental speech perception (perception of individual phonemes or perception of "what is said") are perceptual abilities that provide the foundation for the development of spoken language and effective communication. While there are numerous studies examining segmental perception in children with hearing aids (HAs), there are far fewer studies examining suprasegmental perception, especially for children with greater degrees of residual hearing. Examining the relation between acoustic hearing thresholds, and both segmental and suprasegmental perception for children with HAs, may ultimately enable better device recommendations (bilateral HAs, bimodal devices [one CI and one HA in opposite ears], bilateral CIs) for a particular degree of residual hearing. Examining both types of speech perception is important because segmental and suprasegmental cues are affected differentially by the type of hearing device(s) used (i.e., cochlear implant [CI] and/or HA). Additionally, suprathreshold measures, such as frequency resolution ability, may partially predict benefit from amplification and may assist audiologists in making hearing device recommendations. The purpose of this study is to explore the relationship between audibility (via hearing thresholds and speech intelligibility indices), and segmental and suprasegmental speech perception for children with HAs. A secondary goal is to explore the relationships among frequency resolution ability (via spectral modulation detection [SMD] measures), segmental and suprasegmental speech perception, and receptive language in these same children. A prospective cross-sectional design. Twenty-three children, ages 4 yr 11 mo to 11 yr 11 mo, participated in the study. Participants were recruited from pediatric clinic populations, oral schools for the deaf, and mainstream schools. Audiological history and hearing device information were collected from participants and their families. Segmental and suprasegmental speech perception, SMD, and receptive vocabulary skills were assessed. Correlations were calculated to examine the significance (p < 0.05) of relations between audibility and outcome measures. Measures of audibility and segmental speech perception are not significantly correlated, while low-frequency pure-tone average (unaided) is significantly correlated with suprasegmental speech perception. SMD is significantly correlated with all measures (measures of audibility, segmental and suprasegmental perception and vocabulary). Lastly, although age is not significantly correlated with measures of audibility, it is significantly correlated with all other outcome measures. The absence of a significant correlation between audibility and segmental speech perception might be attributed to overall audibility being maximized through well-fit HAs. The significant correlation between low-frequency unaided audibility and suprasegmental measures is likely due to the strong, predominantly low-frequency nature of suprasegmental acoustic properties. Frequency resolution ability, via SMD performance, is significantly correlated with all outcomes and requires further investigation; its significant correlation with vocabulary suggests that linguistic ability may be partially related to frequency resolution ability. Last, all of the outcome measures are significantly correlated with age, suggestive of developmental effects. American Academy of Audiology

Spatially resolved D-T(2) correlation NMR of porous media.

PubMed

Zhang, Yan; Blümich, Bernhard

2014-05-01

Within the past decade, 2D Laplace nuclear magnetic resonance (NMR) has been developed to analyze pore geometry and diffusion of fluids in porous media on the micrometer scale. Many objects like rocks and concrete are heterogeneous on the macroscopic scale, and an integral analysis of microscopic properties provides volume-averaged information. Magnetic resonance imaging (MRI) resolves this spatial average on the contrast scale set by the particular MRI technique. Desirable contrast parameters for studies of fluid transport in porous media derive from the pore-size distribution and the pore connectivity. These microscopic parameters are accessed by 1D and 2D Laplace NMR techniques. It is therefore desirable to combine MRI and 2D Laplace NMR to image functional information on fluid transport in porous media. Because 2D Laplace resolved MRI demands excessive measuring time, this study investigates the possibility to restrict the 2D Laplace analysis to the sum signals from low-resolution pixels, which correspond to pixels of similar amplitude in high-resolution images. In this exploratory study spatially resolved D-T2 correlation maps from glass beads and mortar are analyzed. Regions of similar contrast are first identified in high-resolution images to locate corresponding pixels in low-resolution images generated with D-T2 resolved MRI for subsequent pixel summation to improve the signal-to-noise ratio of contrast-specific D-T2 maps. This method is expected to contribute valuable information on correlated sample heterogeneity from the macroscopic and the microscopic scales in various types of porous materials including building materials and rock. Copyright © 2014 Elsevier Inc. All rights reserved.

Testing the limits of Paleozoic chronostratigraphic correlation via high-resolution (13Ccarb) biochemostratigraphy across the Llandovery–Wenlock (Silurian) boundary: Is a unified Phanerozoic time scale achievable?

USGS Publications Warehouse

Cramer, Bradley D.; Loydell, David K.; Samtleben, Christian; Munnecke, Axel; Kaljo, Dimitri; Mannik, Peep; Martma, Tonu; Jeppsson, Lennart; Kleffner, Mark A.; Barrick, James E.; Johnson, Craig A.; Emsbo, Poul; Joachimski, Michael M.; Bickert, Torsten; Saltzman, Matthew R.

2010-01-01

The resolution and fidelity of global chronostratigraphic correlation are direct functions of the time period under consideration. By virtue of deep-ocean cores and astrochronology, the Cenozoic and Mesozoic time scales carry error bars of a few thousand years (k.y.) to a few hundred k.y. In contrast, most of the Paleozoic time scale carries error bars of plus or minus a few million years (m.y.), and chronostratigraphic control better than ??1 m.y. is considered "high resolution." The general lack of Paleozoic abyssal sediments and paucity of orbitally tuned Paleozoic data series combined with the relative incompleteness of the Paleozoic stratigraphic record have proven historically to be such an obstacle to intercontinental chronostratigraphic correlation that resolving the Paleozoic time scale to the level achieved during the Mesozoic and Cenozoic was viewed as impractical, impossible, or both. Here, we utilize integrated graptolite, conodont, and carbonate carbon isotope (??13Ccarb) data from three paleocontinents (Baltica, Avalonia, and Laurentia) to demonstrate chronostratigraphic control for upper Llando very through middle Wenlock (Telychian-Sheinwoodian, ~436-426 Ma) strata with a resolution of a few hundred k.y. The interval surrounding the base of the Wenlock Series can now be correlated globally with precision approaching 100 k.y., but some intervals (e.g., uppermost Telychian and upper Shein-woodian) are either yet to be studied in sufficient detail or do not show sufficient biologic speciation and/or extinction or carbon isotopic features to delineate such small time slices. Although producing such resolution during the Paleozoic presents an array of challenges unique to the era, we have begun to demonstrate that erecting a Paleozoic time scale comparable to that of younger eras is achievable. ?? 2010 Geological Society of America.

Multi-Resolution Climate Ensemble Parameter Analysis with Nested Parallel Coordinates Plots.

PubMed

Wang, Junpeng; Liu, Xiaotong; Shen, Han-Wei; Lin, Guang

2017-01-01

Due to the uncertain nature of weather prediction, climate simulations are usually performed multiple times with different spatial resolutions. The outputs of simulations are multi-resolution spatial temporal ensembles. Each simulation run uses a unique set of values for multiple convective parameters. Distinct parameter settings from different simulation runs in different resolutions constitute a multi-resolution high-dimensional parameter space. Understanding the correlation between the different convective parameters, and establishing a connection between the parameter settings and the ensemble outputs are crucial to domain scientists. The multi-resolution high-dimensional parameter space, however, presents a unique challenge to the existing correlation visualization techniques. We present Nested Parallel Coordinates Plot (NPCP), a new type of parallel coordinates plots that enables visualization of intra-resolution and inter-resolution parameter correlations. With flexible user control, NPCP integrates superimposition, juxtaposition and explicit encodings in a single view for comparative data visualization and analysis. We develop an integrated visual analytics system to help domain scientists understand the connection between multi-resolution convective parameters and the large spatial temporal ensembles. Our system presents intricate climate ensembles with a comprehensive overview and on-demand geographic details. We demonstrate NPCP, along with the climate ensemble visualization system, based on real-world use-cases from our collaborators in computational and predictive science.

An Ultra-high Resolution Synthetic Precipitation Data for Ungauged Sites

NASA Astrophysics Data System (ADS)

Kim, Hong-Joong; Choi, Kyung-Min; Oh, Jai-Ho

2018-05-01

Despite the enormous damage caused by record heavy rainfall, the amount of precipitation in areas without observation points cannot be known precisely. One way to overcome these difficulties is to estimate meteorological data at ungauged sites. In this study, we have used observation data over Seoul city to calculate high-resolution (250-meter resolution) synthetic precipitation over a 10-year (2005-2014) period. Furthermore, three cases are analyzed by evaluating the rainfall intensity and performing statistical analysis over the 10-year period. In the case where the typhoon "Meari" passed to the west coast during 28-30 June 2011, the Pearson correlation coefficient was 0.93 for seven validation points, which implies that the temporal correlation between the observed precipitation and synthetic precipitation was very good. It can be confirmed that the time series of observation and synthetic precipitation in the period almost completely matches the observed rainfall. On June 28-29, 2011, the estimation of 10 to 30 mm h-1 of continuous strong precipitation was correct. In addition, it is shown that the synthetic precipitation closely follows the observed precipitation for all three cases. Statistical analysis of 10 years of data reveals a very high correlation coefficient between synthetic precipitation and observed rainfall (0.86). Thus, synthetic precipitation data show good agreement with the observations. Therefore, the 250-m resolution synthetic precipitation amount calculated in this study is useful as basic data in weather applications, such as urban flood detection.

Estimate of the Coulomb correlation energy in CeAg2Ge2 from inverse photoemission and high resolution photoemission spectroscopy

NASA Astrophysics Data System (ADS)

Banik, Soma; Arya, A.; Bendounan, Azzedine; Maniraj, M.; Thamizhavel, A.; Vobornik, I.; Dhar, S. K.; Deb, S. K.

2014-08-01

The occupied and the unoccupied electronic structure of CeAg2Ge2 single crystal has been studied using high resolution photoemission and inverse photoemission spectroscopy, respectively. High resolution photoemission reveals the clear signature of Ce 4f states in the occupied electronic structure which was not observed clearly in our earlier studies. The Coulomb correlation energy in this system has been determined experimentally from the position of the 4f states above and below the Fermi level. Theoretically, the correlation energy has been determined by using the first principles density functional calculations within the generalized gradient approximations taking into account the strong intra-atomic (on-site) interaction Hubbard Ueff term. The calculated valence band shows minor changes in the spectral shape with increasing Ueff due to the fact that the density of Ce 4f state is narrow in the occupied part and is hybridized with the Ce 5d, Ag 4d and Ge 4p states. On the other hand, substantial changes are observed in the spectral shape of the calculated conduction band with increasing Ueff since the density of Ce 4f state is very large in the unoccupied part, compared to other states. The estimated value of correlation energy for CeAg2Ge2 from the experiment and the theory is ≈ 4.2 eV. The resonant photoemission data are analyzed in the framework of the single-impurity Anderson model which further confirms the presence of the Coulomb correlation energy and small hybridization in this system.

The sensitivity of ecosystem service models to choices of input data and spatial resolution

USGS Publications Warehouse

Bagstad, Kenneth J.; Cohen, Erika; Ancona, Zachary H.; McNulty, Steven; Sun, Ge

2018-01-01

Although ecosystem service (ES) modeling has progressed rapidly in the last 10–15 years, comparative studies on data and model selection effects have become more common only recently. Such studies have drawn mixed conclusions about whether different data and model choices yield divergent results. In this study, we compared the results of different models to address these questions at national, provincial, and subwatershed scales in Rwanda. We compared results for carbon, water, and sediment as modeled using InVEST and WaSSI using (1) land cover data at 30 and 300 m resolution and (2) three different input land cover datasets. WaSSI and simpler InVEST models (carbon storage and annual water yield) were relatively insensitive to the choice of spatial resolution, but more complex InVEST models (seasonal water yield and sediment regulation) produced large differences when applied at differing resolution. Six out of nine ES metrics (InVEST annual and seasonal water yield and WaSSI) gave similar predictions for at least two different input land cover datasets. Despite differences in mean values when using different data sources and resolution, we found significant and highly correlated results when using Spearman's rank correlation, indicating consistent spatial patterns of high and low values. Our results confirm and extend conclusions of past studies, showing that in certain cases (e.g., simpler models and national-scale analyses), results can be robust to data and modeling choices. For more complex models, those with different output metrics, and subnational to site-based analyses in heterogeneous environments, data and model choices may strongly influence study findings.

Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease.

PubMed

Lee, N J; Chung, M S; Jung, S C; Kim, H S; Choi, C-G; Kim, S J; Lee, D H; Suh, D C; Kwon, S U; Kang, D-W; Kim, J S

2016-12-01

High-resolution MR imaging has recently been introduced as a promising diagnostic modality in intracranial artery disease. Our aim was to compare high-resolution MR imaging with digital subtraction angiography for the characterization and diagnosis of various intracranial artery diseases. Thirty-seven patients who had undergone both high-resolution MR imaging and DSA for intracranial artery disease were enrolled in our study (August 2011 to April 2014). The time interval between the high-resolution MR imaging and DSA was within 1 month. The degree of stenosis and the minimal luminal diameter were independently measured by 2 observers in both DSA and high-resolution MR imaging, and the results were compared. Two observers independently diagnosed intracranial artery diseases on DSA and high-resolution MR imaging. The time interval between the diagnoses on DSA and high-resolution MR imaging was 2 weeks. Interobserver diagnostic agreement for each technique and intermodality diagnostic agreement for each observer were acquired. High-resolution MR imaging showed moderate-to-excellent agreement (interclass correlation coefficient = 0.892-0.949; κ = 0.548-0.614) and significant correlations (R = 0.766-892) with DSA on the degree of stenosis and minimal luminal diameter. The interobserver diagnostic agreement was good for DSA (κ = 0.643) and excellent for high-resolution MR imaging (κ = 0.818). The intermodality diagnostic agreement was good (κ = 0.704) for observer 1 and moderate (κ = 0.579) for observer 2, respectively. High-resolution MR imaging may be an imaging method comparable with DSA for the characterization and diagnosis of various intracranial artery diseases. © 2016 by American Journal of Neuroradiology.

The robustness of T2 value as a trabecular structural index at multiple spatial resolutions of 7 Tesla MRI.

PubMed

Lee, D K; Song, Y K; Park, B W; Cho, H P; Yeom, J S; Cho, G; Cho, H

2018-04-15

To evaluate the robustness of MR transverse relaxation times of trabecular bone from spin-echo and gradient-echo acquisitions at multiple spatial resolutions of 7 T. The effects of MRI resolutions to T 2 and T2* of trabecular bone were numerically evaluated by Monte Carlo simulations. T 2 , T2*, and trabecular structural indices from multislice multi-echo and UTE acquisitions were measured in defatted human distal femoral condyles on a 7 T scanner. Reference structural indices were extracted from high-resolution microcomputed tomography images. For bovine knee trabecular samples with intact bone marrow, T 2 and T2* were measured by degrading spatial resolutions on a 7 T system. In the defatted trabecular experiment, both T 2 and T2* values showed strong ( |r| > 0.80) correlations with trabecular spacing and number, at a high spatial resolution of 125 µm 3 . The correlations for MR image-segmentation-derived structural indices were significantly degraded ( |r| < 0.50) at spatial resolutions of 250 and 500 µm 3 . The correlations for T2* rapidly dropped ( |r| < 0.50) at a spatial resolution of 500 µm 3 , whereas those for T 2 remained consistently high ( |r| > 0.85). In the bovine trabecular experiments with intact marrow, low-resolution (approximately 1 mm 3 , 2 minutes) T 2 values did not shorten ( |r| > 0.95 with respect to approximately 0.4 mm 3 , 11 minutes) and maintained consistent correlations ( |r| > 0.70) with respect to trabecular spacing (turbo spin echo, 22.5 minutes). T 2 measurements of trabeculae at 7 T are robust with degrading spatial resolution and may be preferable in assessing trabecular spacing index with reduced scan time, when high-resolution 3D micro-MRI is difficult to obtain. © 2018 International Society for Magnetic Resonance in Medicine.

Modified Lagrange invariants and their role in determining transverse and axial imaging resolutions of self-interference incoherent holographic systems.

PubMed

Rosen, Joseph; Kelner, Roy

2014-11-17

The Lagrange invariant is a well-known law for optical imaging systems formulated in the frame of ray optics. In this study, we reformulate this law in terms of wave optics and relate it to the resolution limits of various imaging systems. Furthermore, this modified Lagrange invariant is generalized for imaging along the z axis, resulting with the axial Lagrange invariant which can be used to analyze the axial resolution of various imaging systems. To demonstrate the effectiveness of the theory, analysis of the lateral and the axial imaging resolutions is provided for Fresnel incoherent correlation holography (FINCH) systems.

PSU/WES Interlaboratory Comparative Methodology Study of an Experimental Cementitious Repository Seal Material. Report 2. Final Results.

DTIC Science & Technology

1982-03-01

meter 25 11.0 Microstructure by SEM 11.1 Introduction In order to correlate observed physical and mechanical properties in cured grout samples, a...studied at the two laboratories has proper physical properties , phase composi- tions, and microstructures for the materials used and ages covered...Scanning Electron Microscope Resolution Test Specimen ( Al -W) D. B. Ballard Research Material 100 SEM Resolution Test Specimen (AI-W)., is an alloy of

Functional magnetic resonance imaging phase synchronization as a measure of dynamic functional connectivity.

PubMed

Glerean, Enrico; Salmi, Juha; Lahnakoski, Juha M; Jääskeläinen, Iiro P; Sams, Mikko

2012-01-01

Functional brain activity and connectivity have been studied by calculating intersubject and seed-based correlations of hemodynamic data acquired with functional magnetic resonance imaging (fMRI). To inspect temporal dynamics, these correlation measures have been calculated over sliding time windows with necessary restrictions on the length of the temporal window that compromises the temporal resolution. Here, we show that it is possible to increase temporal resolution by using instantaneous phase synchronization (PS) as a measure of dynamic (time-varying) functional connectivity. We applied PS on an fMRI dataset obtained while 12 healthy volunteers watched a feature film. Narrow frequency band (0.04-0.07 Hz) was used in the PS analysis to avoid artifactual results. We defined three metrics for computing time-varying functional connectivity and time-varying intersubject reliability based on estimation of instantaneous PS across the subjects: (1) seed-based PS, (2) intersubject PS, and (3) intersubject seed-based PS. Our findings show that these PS-based metrics yield results consistent with both seed-based correlation and intersubject correlation methods when inspected over the whole time series, but provide an important advantage of maximal single-TR temporal resolution. These metrics can be applied both in studies with complex naturalistic stimuli (e.g., watching a movie or listening to music in the MRI scanner) and more controlled (e.g., event-related or blocked design) paradigms. A MATLAB toolbox FUNPSY ( http://becs.aalto.fi/bml/software.html ) is openly available for using these metrics in fMRI data analysis.

Understanding deformation with high angular resolution electron backscatter diffraction (HR-EBSD)

NASA Astrophysics Data System (ADS)

Britton, T. B.; Hickey, J. L. R.

2018-01-01

High angular resolution electron backscatter diffraction (HR-EBSD) affords an increase in angular resolution, as compared to ‘conventional’ Hough transform based EBSD, of two orders of magnitude, enabling measurements of relative misorientations of 1 x 10-4 rads (~ 0.006°) and changes in (deviatoric) lattice strain with a precision of 1 x 10-4. This is achieved through direct comparison of two or more diffraction patterns using sophisticated cross-correlation based image analysis routines. Image shifts between zone axes in the two-correlated diffraction pattern are measured with sub-pixel precision and this realises the ability to measure changes in interplanar angles and lattice orientation with a high degree of sensitivity. These shifts are linked to strains and lattice rotations through simple geometry. In this manuscript, we outline the basis of the technique and two case studies that highlight its potential to tackle real materials science challenges, such as deformation patterning in polycrystalline alloys.

Displacement measurement with nanoscale resolution using a coded micro-mark and digital image correlation

NASA Astrophysics Data System (ADS)

Huang, Wei; Ma, Chengfu; Chen, Yuhang

2014-12-01

A method for simple and reliable displacement measurement with nanoscale resolution is proposed. The measurement is realized by combining a common optical microscopy imaging of a specially coded nonperiodic microstructure, namely two-dimensional zero-reference mark (2-D ZRM), and subsequent correlation analysis of the obtained image sequence. The autocorrelation peak contrast of the ZRM code is maximized with well-developed artificial intelligence algorithms, which enables robust and accurate displacement determination. To improve the resolution, subpixel image correlation analysis is employed. Finally, we experimentally demonstrate the quasi-static and dynamic displacement characterization ability of a micro 2-D ZRM.

A possible width-luminosity correlation of the Ca II K1 and Mg II k1 features. [of stellar atmospheres

NASA Technical Reports Server (NTRS)

Ayres, T. R.; Shine, R. A.; Linsky, J. L.

1975-01-01

Existing high resolution stellar profiles of the Ca II and Mg II resonance lines suggest a possible width-luminosity correlation of the K1 minimum features. It is shown that such a correlation can be simply understood if the continuum optical depth of the stellar temperature minimum is relatively independent of surface gravity as suggested by three stars studied in detail.

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, Bradley M.; Stuckelberger, Michael; Guthrey, Harvey

We present that statistical and correlative analysis are increasingly important in the design and study of new materials, from semiconductors to metals. Non-destructive measurement techniques, with high spatial resolution, capable of correlating composition and/or structure with device properties, are few and far between. For the case of polycrystalline and inhomogeneous materials, the added challenge is that nanoscale resolution is in general not compatible with the large sampling areas necessary to have a statistical representation of the specimen under study. For the study of grain cores and grain boundaries in polycrystalline solar absorbers this is of particular importance since their dissimilarmore » behavior and variability throughout the samples makes it difficult to draw conclusions and ultimately optimize the material. In this study, we present a nanoscale in-operando approach based on the multimodal utilization of synchrotron nano x-ray fluorescence and x-ray beam induced current collected for grain core and grain boundary areas and correlated pixel-by-pixel in fully operational Cu(In (1-x)Ga x)Se 2 solar cells. We observe that low gallium cells have grain boundaries that over perform compared to the grain cores and high gallium cells have boundaries that under perform. In conclusion, these results demonstrate how nanoscale correlative X-ray microscopy can guide research pathways towards grain engineering low cost, high efficiency solar cells.« less

Cross Correlation versus Normalized Mutual Information on Image Registration

NASA Technical Reports Server (NTRS)

Tan, Bin; Tilton, James C.; Lin, Guoqing

2016-01-01

This is the first study to quantitatively assess and compare cross correlation and normalized mutual information methods used to register images in subpixel scale. The study shows that the normalized mutual information method is less sensitive to unaligned edges due to the spectral response differences than is cross correlation. This characteristic makes the normalized image resolution a better candidate for band to band registration. Improved band-to-band registration in the data from satellite-borne instruments will result in improved retrievals of key science measurements such as cloud properties, vegetation, snow and fire.

Correlation between the habitats productivity and species richness (amphibians and reptiles) in Portugal through remote sensed data

NASA Astrophysics Data System (ADS)

Teodoro, A. C.; Sillero, N.; Alves, S.; Duarte, L.

2013-10-01

Several biogeographic theories propose that the species richness depends on the structure and ecosystems diversity. The habitat productivity, a surrogate for these variables, can be evaluated through satellite imagery, namely using vegetation indexes (e.g. NDVI). We analyzed the correlation between species richness (from the Portuguese Atlas of Amphibians and Reptiles) and NDVI (from Landsat, MODIS, and Vegetation images). The species richness database contains more than 80000 records, collected from bibliographic sources (at 1 or 10 km of spatial resolution) and fieldwork sampling stations (recorded with GPS devices). Several study areas were chosen for Landsat images (three subsets), and all Portugal for MODIS and Vegetation images. The Landsat subareas had different climatic and habitat characteristics, located in the north, center and south of Portugal. Different species richness datasets were used depending on the image spatial resolution: data with metric resolution were used for Landsat, and with 1 km resolution, for MODIS and Vegetation images. The NDVI indexes and all the images were calculated/processed in an open source software (Quantum GIS). Several plug-ins were applied in order to automatize several procedures. We did not find any correlation between the species richness of amphibians and reptiles (not even after separating both groups by species of Atlantic and Mediterranean affinity) and the NDVI calculated with Landsat, MODIS and Vegetation images. Our results may fail to find a relationship because as the species richness is not correlated with only one variable (NDVI), and thus other environmental variables must be considered.

Recent Advancements in DNA Damage-Transcription Crosstalk and High-Resolution Mapping of DNA Breaks.

PubMed

Vitelli, Valerio; Galbiati, Alessandro; Iannelli, Fabio; Pessina, Fabio; Sharma, Sheetal; d'Adda di Fagagna, Fabrizio

2017-08-31

Until recently, DNA damage arising from physiological DNA metabolism was considered a detrimental by-product for cells. However, an increasing amount of evidence has shown that DNA damage could have a positive role in transcription activation. In particular, DNA damage has been detected in transcriptional elements following different stimuli. These physiological DNA breaks are thought to be instrumental for the correct expression of genomic loci through different mechanisms. In this regard, although a plethora of methods are available to precisely map transcribed regions and transcription start sites, commonly used techniques for mapping DNA breaks lack sufficient resolution and sensitivity to draw a robust correlation between DNA damage generation and transcription. Recently, however, several methods have been developed to map DNA damage at single-nucleotide resolution, thus providing a new set of tools to correlate DNA damage and transcription. Here, we review how DNA damage can positively regulate transcription initiation, the current techniques for mapping DNA breaks at high resolution, and how these techniques can benefit future studies of DNA damage and transcription.

Study of structural colour of Hebomoia glaucippe butterfly wing scales

NASA Astrophysics Data System (ADS)

Shur, V. Ya; Kuznetsov, D. K.; Pryakhina, V. I.; Kosobokov, M. S.; Zubarev, I. V.; Boymuradova, S. K.; Volchetskaya, K. V.

2017-10-01

Structural colours of Hebomoia glaucippe butterfly wing scales have been studied experimentally using high resolution scanning electron microscopy. Visualization of scales structures and computer simulation allowed distinguishing correlation between nanostructures on the scales and their colour.

Resolution of hypertension and proteinuria after preeclampsia.

PubMed

Berks, Durk; Steegers, Eric A P; Molas, Marek; Visser, Willy

2009-12-01

To estimate the time required for hypertension and proteinuria to resolve after preeclampsia, and to estimate how this time to resolution correlates with the levels of blood pressure and proteinuria during preeclampsia and prolonging pregnancy after the development of preeclampsia. This is a historic prospective cohort study of 205 preeclamptic women who were admitted between 1990 and 1992 at the Erasmus MC Medical Centre, Rotterdam, The Netherlands. Data were collected at 1.5, 3, 6, 12, 18, and 24 months after delivery. Hypertension was defined as a blood pressure 140/90 mm Hg or higher or use of antihypertensive drugs. Proteinuria was defined as 0.3 g/d or more. Resolution of hypertension and proteinuria were analyzed with the Turnbull extension to the Kaplan-Meier procedure. Correlations were calculated with an accelerated failure time model. At 3 months postpartum, 39% of women still had hypertension, which decreased to 18% at 2 years postpartum. Resolution time increased by 60% (P<.001) for every 10-mm Hg increase in maximal systolic blood pressure, 40% (P=.044) for every 10-mm Hg increase in maximal diastolic blood pressure, and 3.6% (P=.001) for every 1-day increase in the diagnosis-to-delivery interval. At 3 months postpartum, 14% still had proteinuria, which decreased to 2% at 2 years postpartum. Resolution time increased by 16% (P=.001) for every 1-g/d increase in maximal proteinuria. Gestational age at onset of preeclampsia was not correlated with resolution time of hypertension and proteinuria. The severity of preeclampsia and the time interval between diagnosis and delivery are associated with postpartum time to resolution of hypertension and proteinuria. After preeclampsia, it can take up to 2 years for hypertension and proteinuria to resolve. Therefore, the authors suggest that further invasive diagnostic tests for underlying renal disease may be postponed until 2 years postpartum. III.

Penalized Weighted Least-Squares Approach to Sinogram Noise Reduction and Image Reconstruction for Low-Dose X-Ray Computed Tomography

PubMed Central

Wang, Jing; Li, Tianfang; Lu, Hongbing; Liang, Zhengrong

2006-01-01

Reconstructing low-dose X-ray CT (computed tomography) images is a noise problem. This work investigated a penalized weighted least-squares (PWLS) approach to address this problem in two dimensions, where the WLS considers first- and second-order noise moments and the penalty models signal spatial correlations. Three different implementations were studied for the PWLS minimization. One utilizes a MRF (Markov random field) Gibbs functional to consider spatial correlations among nearby detector bins and projection views in sinogram space and minimizes the PWLS cost function by iterative Gauss-Seidel algorithm. Another employs Karhunen-Loève (KL) transform to de-correlate data signals among nearby views and minimizes the PWLS adaptively to each KL component by analytical calculation, where the spatial correlation among nearby bins is modeled by the same Gibbs functional. The third one models the spatial correlations among image pixels in image domain also by a MRF Gibbs functional and minimizes the PWLS by iterative successive over-relaxation algorithm. In these three implementations, a quadratic functional regularization was chosen for the MRF model. Phantom experiments showed a comparable performance of these three PWLS-based methods in terms of suppressing noise-induced streak artifacts and preserving resolution in the reconstructed images. Computer simulations concurred with the phantom experiments in terms of noise-resolution tradeoff and detectability in low contrast environment. The KL-PWLS implementation may have the advantage in terms of computation for high-resolution dynamic low-dose CT imaging. PMID:17024831

Emotional cues enhance the attentional effects on spatial and temporal resolution.

PubMed

Bocanegra, Bruno R; Zeelenberg, René

2011-12-01

In the present study, we demonstrated that the emotional significance of a spatial cue enhances the effect of covert attention on spatial and temporal resolution (i.e., our ability to discriminate small spatial details and fast temporal flicker). Our results indicated that fearful face cues, as compared with neutral face cues, enhanced the attentional benefits in spatial resolution but also enhanced the attentional deficits in temporal resolution. Furthermore, we observed that the overall magnitudes of individuals' attentional effects correlated strongly with the magnitude of the emotion × attention interaction effect. Combined, these findings provide strong support for the idea that emotion enhances the strength of a cue's attentional response.

Fabrication of [001]-oriented tungsten tips for high resolution scanning tunneling microscopy

PubMed Central

Chaika, A. N.; Orlova, N. N.; Semenov, V. N.; Postnova, E. Yu.; Krasnikov, S. A.; Lazarev, M. G.; Chekmazov, S. V.; Aristov, V. Yu.; Glebovsky, V. G.; Bozhko, S. I.; Shvets, I. V.

2014-01-01

The structure of the [001]-oriented single crystalline tungsten probes sharpened in ultra-high vacuum using electron beam heating and ion sputtering has been studied using scanning and transmission electron microscopy. The electron microscopy data prove reproducible fabrication of the single-apex tips with nanoscale pyramids grained by the {011} planes at the apexes. These sharp, [001]-oriented tungsten tips have been successfully utilized in high resolution scanning tunneling microscopy imaging of HOPG(0001), SiC(001) and graphene/SiC(001) surfaces. The electron microscopy characterization performed before and after the high resolution STM experiments provides direct correlation between the tip structure and picoscale spatial resolution achieved in the experiments. PMID:24434734

Elemental and lattice-parameter mapping of binary oxide superlattices of (LaNiO 3 ) 4 /(LaMnO 3 ) 2 at atomic resolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwon, Ji-Hwan; Lu, Ping; Hoffman, Jason

2016-12-19

We construct the elemental distribution and lattice strain maps from the measured atomic column positions in a (LaNiO3)(4)/(LaMnO3)(2) superlattice over a large field of view. The correlation between the distribution of B-cations and the lattice parameter in the form of Vegard's law is validated using atomic resolution energy dispersive x-ray spectroscopy (EDS). The maps show negligible Mn intermixing in the LaNiO3 layer, while Ni intermixing in the LaMnO3 layer improves away from the substrate interface to 9.5 atomic% from the 8th period onwards, indicating that the superlattice interfacial sharpness is established as the distance from the substrate increases. The mapsmore » allow an observation of the compositional defects of the B-sites, which is not possible by Z-contrast alone. Thus, this study demonstrates a promising approach for atomic scale correlative study of lattice strain and composition, and a method for the calibration of atomic resolution EDS maps.« less

Study of Velocity and Magnetic Field Fluctuations at Kinetic Scale with the DSCOVR Data

NASA Astrophysics Data System (ADS)

Vech, D.; Kasper, J. C.; Klein, K. G.; Hegedus, A. M.; Stevens, M. L.; Case, A. W.; Szabo, A.; Koval, A.

2016-12-01

The Deep Space Climate Observatory (DSCOVR), launched in 2015, performs high resolution measurements of the solar wind at the L1 vantage point. The Faraday cup onboard DSCOVR is capable of sampling solar wind velocity distribution functions at cadences up to 1 Hz, which is complemented by the 50 samples/sec magnetic field experiment. The combined usage of these data makes it possible to study kinetic scale physics, in particular turbulent fluctuations and the associated dissipation processes with unprecedented resolution. In this work we investigate recently obtained data sets and analyze correlations between the magnetic field and the measured currents in different energy/charge windows. The goal of the study is to search for active wave-particle interactions at specific locations in phase space. We estimate the significance of these correlations and discuss the implications for our understanding of kinetic scale physics of the solar wind.

Localization, correlation, and visualization of electroencephalographic surface electrodes and brain anatomy in epilepsy studies

NASA Astrophysics Data System (ADS)

Brinkmann, Benjamin H.; O'Brien, Terence J.; Robb, Richard A.; Sharbrough, Frank W.

1997-05-01

Advances in neuroimaging have enhanced the clinician's ability to localize the epileptogenic zone in focal epilepsy, but 20-50 percent of these cases still remain unlocalized. Many sophisticated modalities have been used to study epilepsy, but scalp electrode recorded electroencephalography is particularly useful due to its noninvasive nature and excellent temporal resolution. This study is aimed at specific locations of scalp electrode EEG information for correlation with anatomical structures in the brain. 3D position localizing devices commonly used in virtual reality systems are used to digitize the coordinates of scalp electrodes in a standard clinical configuration. The electrode coordinates are registered with a high- resolution MRI dataset using a robust surface matching algorithm. Volume rendering can then be used to visualize the electrodes and electrode potentials interpolated over the scalp. The accuracy of the coordinate registration is assessed quantitatively with a realistic head phantom.

Multispectral image sharpening using wavelet transform techniques and spatial correlation of edges

USGS Publications Warehouse

Lemeshewsky, George P.; Schowengerdt, Robert A.

2000-01-01

Several reported image fusion or sharpening techniques are based on the discrete wavelet transform (DWT). The technique described here uses a pixel-based maximum selection rule to combine respective transform coefficients of lower spatial resolution near-infrared (NIR) and higher spatial resolution panchromatic (pan) imagery to produce a sharpened NIR image. Sharpening assumes a radiometric correlation between the spectral band images. However, there can be poor correlation, including edge contrast reversals (e.g., at soil-vegetation boundaries), between the fused images and, consequently, degraded performance. To improve sharpening, a local area-based correlation technique originally reported for edge comparison with image pyramid fusion is modified for application with the DWT process. Further improvements are obtained by using redundant, shift-invariant implementation of the DWT. Example images demonstrate the improvements in NIR image sharpening with higher resolution pan imagery.

Visualization of the aneurysm wall: a 7.0-tesla magnetic resonance imaging study.

PubMed

Kleinloog, Rachel; Korkmaz, Emine; Zwanenburg, Jaco J M; Kuijf, Hugo J; Visser, Fredy; Blankena, Roos; Post, Jan A; Ruigrok, Ynte M; Luijten, Peter R; Regli, Luca; Rinkel, Gabriel J E; Verweij, Bon H

2014-12-01

Risk prediction of rupture of intracranial aneurysms is poor and is based mainly on lumen characteristics. However, characteristics of the aneurysm wall may be more informative predictors. The limited resolution of currently available imaging techniques and the thin aneurysm wall make imaging of wall thickness challenging. To introduce a novel protocol for imaging wall thickness variation using ultra--high-resolution 7.0-Tesla (7.0-T) magnetic resonance imaging (MRI). We studied 33 unruptured intracranial aneurysms in 24 patients with a T1-weighted 3-dimensional magnetization-prepared inversion-recovery turbo-spin-echo whole-brain sequence with a resolution of 0.8 × 0.8 × 0.8 mm. We performed a validation study with a wedge phantom and with 2 aneurysm wall biopsies obtained during aneurysm treatment using ex vivo MRI and histological examination and correlating variations in MRI signal intensity with variations in actual thickness of the aneurysm wall. In vivo, the aneurysm wall was visible in 28 of the 33 aneurysms. Variation in signal intensity was observed in all visible aneurysm walls. Ex vivo MRI showed variation in signal intensity across the wall of the biopsies, similar to that observed on the in vivo images. Signal intensity and actual thickness in both biopsies had a linear correlation, with Pearson correlation coefficients of 0.85 and 0.86. Unruptured intracranial aneurysm wall and its variation in thickness can be visualized with 7.0-T MRI. Aneurysm wall thickness variation can now be further studied as a risk factor for rupture in prospective studies.

Quantitative imaging of peripheral trabecular bone microarchitecture using MDCT.

PubMed

Chen, Cheng; Zhang, Xiaoliu; Guo, Junfeng; Jin, Dakai; Letuchy, Elena M; Burns, Trudy L; Levy, Steven M; Hoffman, Eric A; Saha, Punam K

2018-01-01

Osteoporosis associated with reduced bone mineral density (BMD) and microarchitectural changes puts patients at an elevated risk of fracture. Modern multidetector row CT (MDCT) technology, producing high spatial resolution at increasingly lower dose radiation, is emerging as a viable modality for trabecular bone (Tb) imaging. Wide variation in CT scanners raises concerns of data uniformity in multisite and longitudinal studies. A comprehensive cadaveric study was performed to evaluate MDCT-derived Tb microarchitectural measures. A human pilot study was performed comparing continuity of Tb measures estimated from two MDCT scanners with significantly different image resolution features. Micro-CT imaging of cadaveric ankle specimens (n=25) was used to examine the validity of MDCT-derived Tb microarchitectural measures. Repeat scan reproducibility of MDCT-based Tb measures and their ability to predict mechanical properties were examined. To assess multiscanner data continuity of Tb measures, the distal tibias of 20 volunteers (age:26.2±4.5Y,10F) were scanned using the Siemens SOMATOM Definition Flash and the higher resolution Siemens SOMATOM Force scanners with an average 45-day time gap between scans. The correlation of Tb measures derived from the two scanners over 30% and 60% peel regions at the 4% to 8% of distal tibia was analyzed. MDCT-based Tb measures characterizing bone network area density, plate-rod microarchitecture, and transverse trabeculae showed good correlations (r∈0.85,0.92) with the gold standard micro-CT-derived values of matching Tb measures. However, other MDCT-derived Tb measures characterizing trabecular thickness and separation, erosion index, and structure model index produced weak correlation (r<0.8) with their micro-CT-derived values. Most MDCT Tb measures were found repeatable (ICC∈0.94,0.98). The Tb plate-width measure showed a strong correlation (r = 0.89) with experimental yield stress, while the transverse trabecular measure produced the highest correlation (r = 0.81) with Young's modulus. The data continuity experiment showed that, despite significant differences in image resolution between two scanners (10% MTF along xy-plane and z-direction - Flash: 16.2 and 17.9 lp/cm; Force: 24.8 and 21.0 lp/cm), most Tb measures had high Pearson correlations (r > 0.95) between values estimated from the two scanners. Relatively lower correlation coefficients were observed for the bone network area density (r = 0.91) and Tb separation (r = 0.93) measures. Most MDCT-derived Tb microarchitectural measures are reproducible and their values derived from two scanners strongly correlate with each other as well as with bone strength. This study has highlighted those MDCT-derived measures which show the greatest promise for characterization of bone network area density, plate-rod and transverse trabecular distributions with a good correlation (r ≥ 0.85) compared with their micro-CT-derived values. At the same time, other measures representing trabecular thickness and separation, erosion index, and structure model index produced weak correlations (r < 0.8) with their micro-CT-derived values, failing to accurately portray the projected trabecular microarchitectural features. Strong correlations of Tb measures estimated from two scanners suggest that image data from different scanners can be used successfully in multisite and longitudinal studies with linear calibration required for some measures. In summary, modern MDCT scanners are suitable for effective quantitative imaging of peripheral Tb microarchitecture if care is taken to focus on appropriate quantitative metrics. © 2017 American Association of Physicists in Medicine.

Filling the gap: adding super-resolution to array tomography for correlated ultrastructural and molecular identification of electrical synapses at the C. elegans connectome.

PubMed

Markert, Sebastian Matthias; Britz, Sebastian; Proppert, Sven; Lang, Marietta; Witvliet, Daniel; Mulcahy, Ben; Sauer, Markus; Zhen, Mei; Bessereau, Jean-Louis; Stigloher, Christian

2016-10-01

Correlating molecular labeling at the ultrastructural level with high confidence remains challenging. Array tomography (AT) allows for a combination of fluorescence and electron microscopy (EM) to visualize subcellular protein localization on serial EM sections. Here, we describe an application for AT that combines near-native tissue preservation via high-pressure freezing and freeze substitution with super-resolution light microscopy and high-resolution scanning electron microscopy (SEM) analysis on the same section. We established protocols that combine SEM with structured illumination microscopy (SIM) and direct stochastic optical reconstruction microscopy (dSTORM). We devised a method for easy, precise, and unbiased correlation of EM images and super-resolution imaging data using endogenous cellular landmarks and freely available image processing software. We demonstrate that these methods allow us to identify and label gap junctions in Caenorhabditis elegans with precision and confidence, and imaging of even smaller structures is feasible. With the emergence of connectomics, these methods will allow us to fill in the gap-acquiring the correlated ultrastructural and molecular identity of electrical synapses.

Validation of a clinical assessment of spectral-ripple resolution for cochlear implant users.

PubMed

Drennan, Ward R; Anderson, Elizabeth S; Won, Jong Ho; Rubinstein, Jay T

2014-01-01

Nonspeech psychophysical tests of spectral resolution, such as the spectral-ripple discrimination task, have been shown to correlate with speech-recognition performance in cochlear implant (CI) users. However, these tests are best suited for use in the research laboratory setting and are impractical for clinical use. A test of spectral resolution that is quicker and could more easily be implemented in the clinical setting has been developed. The objectives of this study were (1) To determine whether this new clinical ripple test would yield individual results equivalent to the longer, adaptive version of the ripple-discrimination test; (2) To evaluate test-retest reliability for the clinical ripple measure; and (3) To examine the relationship between clinical ripple performance and monosyllabic word recognition in quiet for a group of CI listeners. Twenty-eight CI recipients participated in the study. Each subject was tested on both the adaptive and the clinical versions of spectral ripple discrimination, as well as consonant-nucleus-consonant word recognition in quiet. The adaptive version of spectral ripple used a two-up, one-down procedure for determining spectral ripple discrimination threshold. The clinical ripple test used a method of constant stimuli, with trials for each of 12 fixed ripple densities occurring six times in random order. Results from the clinical ripple test (proportion correct) were then compared with ripple-discrimination thresholds (in ripples per octave) from the adaptive test. The clinical ripple test showed strong concurrent validity, evidenced by a good correlation between clinical ripple and adaptive ripple results (r = 0.79), as well as a correlation with word recognition (r = 0.7). Excellent test-retest reliability was also demonstrated with a high test-retest correlation (r = 0.9). The clinical ripple test is a reliable nonlinguistic measure of spectral resolution, optimized for use with CI users in a clinical setting. The test might be useful as a diagnostic tool or as a possible surrogate outcome measure for evaluating treatment effects in hearing.

Spatial variability of the Black Sea surface temperature from high resolution modeling and satellite measurements

NASA Astrophysics Data System (ADS)

Mizyuk, Artem; Senderov, Maxim; Korotaev, Gennady

2016-04-01

Large number of numerical ocean models were implemented for the Black Sea basin during last two decades. They reproduce rather similar structure of synoptical variability of the circulation. Since 00-s numerical studies of the mesoscale structure are carried out using high performance computing (HPC). With the growing capacity of computing resources it is now possible to reconstruct the Black Sea currents with spatial resolution of several hundreds meters. However, how realistic these results can be? In the proposed study an attempt is made to understand which spatial scales are reproduced by ocean model in the Black Sea. Simulations are made using parallel version of NEMO (Nucleus for European Modelling of the Ocean). A two regional configurations with spatial resolutions 5 km and 2.5 km are described. Comparison of the SST from simulations with two spatial resolutions shows rather qualitative difference of the spatial structures. Results of high resolution simulation are compared also with satellite observations and observation-based products from Copernicus using spatial correlation and spectral analysis. Spatial scales of correlations functions for simulated and observed SST are rather close and differs much from satellite SST reanalysis. Evolution of spectral density for modelled SST and reanalysis showed agreed time periods of small scales intensification. Using of the spectral analysis for satellite measurements is complicated due to gaps. The research leading to this results has received funding from Russian Science Foundation (project № 15-17-20020)

Impact of positional difference on the measurement of breast density using MRI.

PubMed

Chen, Jeon-Hor; Chan, Siwa; Tang, Yi-Ting; Hon, Jia Shen; Tseng, Po-Chuan; Cheriyan, Angela T; Shah, Nikita Rakesh; Yeh, Dah-Cherng; Lee, San-Kan; Chen, Wen-Pin; McLaren, Christine E; Su, Min-Ying

2015-05-01

This study investigated the impact of arms/hands and body position on the measurement of breast density using MRI. Noncontrast-enhanced T1-weighted images were acquired from 32 healthy women. Each subject received four MR scans using different experimental settings, including a high resolution hands-up, a low resolution hands-up, a high resolution hands-down, and finally, another high resolution hands-up after repositioning. The breast segmentation was performed using a fully automatic chest template-based method. The breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) measured from the four MR scan settings were analyzed. A high correlation of BV, FV, and PD between any pair of the four MR scans was noted (r > 0.98 for all). Using the generalized estimating equation method, a statistically significant difference in mean BV among four settings was noted (left breast, score test p = 0.0056; right breast, score test p = 0.0016), adjusted for age and body mass index. Despite differences in BV, there were no statistically significant differences in the mean PDs among the four settings (p > 0.10 for left and right breasts). Using Bland-Altman plots, the smallest mean difference/bias and standard deviations for BV, FV, and PD were noted when comparing hands-up high vs low resolution when the breast positions were exactly the same. The authors' study showed that BV, FV, and PD measurements from MRI of different positions were highly correlated. BV may vary with positions but the measured PD did not differ significantly between positions. The study suggested that the percent density analyzed from MRI studies acquired using different arms/hands and body positions from multiple centers can be combined for analysis.

Time-domain induced polarization - an analysis of Cole-Cole parameter resolution and correlation using Markov Chain Monte Carlo inversion

NASA Astrophysics Data System (ADS)

Madsen, Line Meldgaard; Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

2017-12-01

The application of time-domain induced polarization (TDIP) is increasing with advances in acquisition techniques, data processing and spectral inversion schemes. An inversion of TDIP data for the spectral Cole-Cole parameters is a non-linear problem, but by applying a 1-D Markov Chain Monte Carlo (MCMC) inversion algorithm, a full non-linear uncertainty analysis of the parameters and the parameter correlations can be accessed. This is essential to understand to what degree the spectral Cole-Cole parameters can be resolved from TDIP data. MCMC inversions of synthetic TDIP data, which show bell-shaped probability distributions with a single maximum, show that the Cole-Cole parameters can be resolved from TDIP data if an acquisition range above two decades in time is applied. Linear correlations between the Cole-Cole parameters are observed and by decreasing the acquisitions ranges, the correlations increase and become non-linear. It is further investigated how waveform and parameter values influence the resolution of the Cole-Cole parameters. A limiting factor is the value of the frequency exponent, C. As C decreases, the resolution of all the Cole-Cole parameters decreases and the results become increasingly non-linear. While the values of the time constant, τ, must be in the acquisition range to resolve the parameters well, the choice between a 50 per cent and a 100 per cent duty cycle for the current injection does not have an influence on the parameter resolution. The limits of resolution and linearity are also studied in a comparison between the MCMC and a linearized gradient-based inversion approach. The two methods are consistent for resolved models, but the linearized approach tends to underestimate the uncertainties for poorly resolved parameters due to the corresponding non-linear features. Finally, an MCMC inversion of 1-D field data verifies that spectral Cole-Cole parameters can also be resolved from TD field measurements.

On the effect of irradiation-induced resolution in modelling fission gas release in UO2 LWR fuel

NASA Astrophysics Data System (ADS)

Lösönen, Pekka

2017-12-01

Irradiation resolution of gas atoms and vacancies from intra- and intergranular bubbles in sintered UO2 fuel was studied by comparing macroscopic models with a more mechanistic approach. The applied macroscopic models imply the resolution rate of gas atoms to be proportional to gas concentration in intragranular bubbles and at grain boundary (including intergranular bubbles). A relation was established between the macroscopic models and a single encounter of an energetic fission fragment with a bubble. The effect of bubble size on resolution was quantified. The number of resoluted gas atoms per encounter of a fission fragment per bubble was of the same order of magnitude for intra- and intergranular bubbles. However, the resulting macroscopic resolution rate of gas atoms was about two orders of magnitude larger from intragranular bubbles. The number of vacancies resoluted from a grain face bubble by a passing fission fragment was calculated. The obtained correlations for resolution of gas atoms from intragranular bubbles and grain boundaries and for resolution of vacancies from grain face bubbles were used to demonstrate the effect of irradiation resolution on fission gas release.

Contribution of high-resolution correlative imaging techniques in the study of the liver sieve in three-dimensions.

PubMed

Braet, Filip; Wisse, Eddie; Bomans, Paul; Frederik, Peter; Geerts, Willie; Koster, Abraham; Soon, Lilian; Ringer, Simon

2007-03-01

Correlative microscopy has become increasingly important for the analysis of the structure, function, and dynamics of cells. This is largely due to the result of recent advances in light-, probe-, laser- and various electron microscopy techniques that facilitate three-dimensional studies. Furthermore, the improved understanding in the past decade of imaging cell compartments in the third dimension has resulted largely from the availability of powerful computers, fast high-resolution CCD cameras, specifically developed imaging analysis software, and various probes designed for labeling living and or fixed cells. In this paper, we review different correlative high-resolution imaging methodologies and how these microscopy techniques facilitated the accumulation of new insights in the morpho-functional and structural organization of the hepatic sieve. Various aspects of hepatic endothelial fenestrae regarding their structure, origin, dynamics, and formation will be explored throughout this paper by comparing the results of confocal laser scanning-, correlative fluorescence and scanning electron-, atomic force-, and whole-mount electron microscopy. Furthermore, the recent advances of vitrifying cells with the vitrobot in combination with the glove box for the preparation of cells for cryo-electron microscopic investigation will be discussed. Finally, the first transmission electron tomography data of the liver sieve in three-dimensions are presented. The obtained data unambiguously show the involvement of special domains in the de novo formation and disappearance of hepatic fenestrae, and focuses future research into the (supra)molecular structure of the fenestrae-forming center, defenestration center and fenestrae-, and sieve plate cytoskeleton ring by using advanced cryo-electron tomography. (c) 2007 Wiley-Liss, Inc.

In vivo correlation mapping microscopy

NASA Astrophysics Data System (ADS)

McGrath, James; Alexandrov, Sergey; Owens, Peter; Subhash, Hrebesh; Leahy, Martin

2016-04-01

To facilitate regular assessment of the microcirculation in vivo, noninvasive imaging techniques such as nailfold capillaroscopy are required in clinics. Recently, a correlation mapping technique has been applied to optical coherence tomography (OCT), which extends the capabilities of OCT to microcirculation morphology imaging. This technique, known as correlation mapping optical coherence tomography, has been shown to extract parameters, such as capillary density and vessel diameter, and key clinical markers associated with early changes in microvascular diseases. However, OCT has limited spatial resolution in both the transverse and depth directions. Here, we extend this correlation mapping technique to other microscopy modalities, including confocal microscopy, and take advantage of the higher spatial resolution offered by these modalities. The technique is achieved as a processing step on microscopy images and does not require any modification to the microscope hardware. Results are presented which show that this correlation mapping microscopy technique can extend the capabilities of conventional microscopy to enable mapping of vascular networks in vivo with high spatial resolution in both the transverse and depth directions.

Correlation between protein sequence similarity and x-ray diffraction quality in the protein data bank.

PubMed

Lu, Hui-Meng; Yin, Da-Chuan; Ye, Ya-Jing; Luo, Hui-Min; Geng, Li-Qiang; Li, Hai-Sheng; Guo, Wei-Hong; Shang, Peng

2009-01-01

As the most widely utilized technique to determine the 3-dimensional structure of protein molecules, X-ray crystallography can provide structure of the highest resolution among the developed techniques. The resolution obtained via X-ray crystallography is known to be influenced by many factors, such as the crystal quality, diffraction techniques, and X-ray sources, etc. In this paper, the authors found that the protein sequence could also be one of the factors. We extracted information of the resolution and the sequence of proteins from the Protein Data Bank (PDB), classified the proteins into different clusters according to the sequence similarity, and statistically analyzed the relationship between the sequence similarity and the best resolution obtained. The results showed that there was a pronounced correlation between the sequence similarity and the obtained resolution. These results indicate that protein structure itself is one variable that may affect resolution when X-ray crystallography is used.

Rainbow correlation imaging with macroscopic twin beam

NASA Astrophysics Data System (ADS)

Allevi, Alessia; Bondani, Maria

2017-06-01

We present the implementation of a correlation-imaging protocol that exploits both the spatial and spectral correlations of macroscopic twin-beam states generated by parametric downconversion. In particular, the spectral resolution of an imaging spectrometer coupled to an EMCCD camera is used in a proof-of-principle experiment to encrypt and decrypt a simple code to be transmitted between two parties. In order to optimize the trade-off between visibility and resolution, we provide the characterization of the correlation images as a function of the spatio-spectral properties of twin beams generated at different pump power values.

Correlation Plenoptic Imaging.

PubMed

D'Angelo, Milena; Pepe, Francesco V; Garuccio, Augusto; Scarcelli, Giuliano

2016-06-03

Plenoptic imaging is a promising optical modality that simultaneously captures the location and the propagation direction of light in order to enable three-dimensional imaging in a single shot. However, in standard plenoptic imaging systems, the maximum spatial and angular resolutions are fundamentally linked; thereby, the maximum achievable depth of field is inversely proportional to the spatial resolution. We propose to take advantage of the second-order correlation properties of light to overcome this fundamental limitation. In this Letter, we demonstrate that the correlation in both momentum and position of chaotic light leads to the enhanced refocusing power of correlation plenoptic imaging with respect to standard plenoptic imaging.

Correlation Plenoptic Imaging

NASA Astrophysics Data System (ADS)

D'Angelo, Milena; Pepe, Francesco V.; Garuccio, Augusto; Scarcelli, Giuliano

2016-06-01

Plenoptic imaging is a promising optical modality that simultaneously captures the location and the propagation direction of light in order to enable three-dimensional imaging in a single shot. However, in standard plenoptic imaging systems, the maximum spatial and angular resolutions are fundamentally linked; thereby, the maximum achievable depth of field is inversely proportional to the spatial resolution. We propose to take advantage of the second-order correlation properties of light to overcome this fundamental limitation. In this Letter, we demonstrate that the correlation in both momentum and position of chaotic light leads to the enhanced refocusing power of correlation plenoptic imaging with respect to standard plenoptic imaging.

Grain engineering: How nanoscale inhomogeneities can control charge collection in solar cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, Bradley M.; Stuckelberger, Michael; Guthrey, Harvey

Statistical and correlative analysis are increasingly important in the design and study of new materials, from semiconductors to metals. Non-destructive measurement techniques, with high spatial resolution, capable of correlating composition and/or structure with device properties, are few and far between. For the case of polycrystalline and inhomogeneous materials, the added challenge is that nanoscale resolution is in general not compatible with the large sampling areas necessary to have a statistical representation of the specimen under study. For the study of grain cores and grain boundaries in polycrystalline solar absorbers this is of particular importance since their dissimilar behavior and variabilitymore » throughout the samples makes it difficult to draw conclusions and ultimately optimize the material. In this study, we present a nanoscale in-operando approach based on the multimodal utilization of synchrotron nano x-ray fluorescence and x-ray beam induced current collected for grain core and grain boundary areas and correlated pixel-by-pixel in fully operational Cu(In(1-x)Gax)Se2Cu(In(1-x)Gax)Se2 solar cells. We observe that low gallium cells have grain boundaries that over perform compared to the grain cores and high gallium cells have boundaries that under perform. These results demonstrate how nanoscale correlative X-ray microscopy can guide research pathways towards grain engineering low cost, high efficiency solar cells.« less

Grain engineering: How nanoscale inhomogeneities can control charge collection in solar cells

DOE PAGES

West, Bradley M.; Stuckelberger, Michael; Guthrey, Harvey; ...

2016-12-16

We present that statistical and correlative analysis are increasingly important in the design and study of new materials, from semiconductors to metals. Non-destructive measurement techniques, with high spatial resolution, capable of correlating composition and/or structure with device properties, are few and far between. For the case of polycrystalline and inhomogeneous materials, the added challenge is that nanoscale resolution is in general not compatible with the large sampling areas necessary to have a statistical representation of the specimen under study. For the study of grain cores and grain boundaries in polycrystalline solar absorbers this is of particular importance since their dissimilarmore » behavior and variability throughout the samples makes it difficult to draw conclusions and ultimately optimize the material. In this study, we present a nanoscale in-operando approach based on the multimodal utilization of synchrotron nano x-ray fluorescence and x-ray beam induced current collected for grain core and grain boundary areas and correlated pixel-by-pixel in fully operational Cu(In (1-x)Ga x)Se 2 solar cells. We observe that low gallium cells have grain boundaries that over perform compared to the grain cores and high gallium cells have boundaries that under perform. In conclusion, these results demonstrate how nanoscale correlative X-ray microscopy can guide research pathways towards grain engineering low cost, high efficiency solar cells.« less

Spatial resolution of pace mapping of idiopathic ventricular tachycardia/ectopy originating in the right ventricular outflow tract.

PubMed

Bogun, Frank; Taj, Majid; Ting, Michael; Kim, Hyungjin Myra; Reich, Stephen; Good, Eric; Jongnarangsin, Krit; Chugh, Aman; Pelosi, Frank; Oral, Hakan; Morady, Fred

2008-03-01

Pace mapping has been used to identify the site of origin of focal ventricular arrhythmias. The spatial resolution of pace mapping has not been adequately quantified using currently available three-dimensional mapping systems. The purpose of this study was to determine the spatial resolution of pace mapping in patients with idiopathic ventricular tachycardia or premature ventricular contractions originating in the right ventricular outflow tract. In 16 patients with idiopathic ventricular tachycardia/ectopy from the right ventricular outflow tract, comparisons and classifications of pace maps were performed by two observers (good pace map: match >10/12 leads; inadequate pace map: match < or =10/12 leads) and a customized MATLAB 6.0 program (assessing correlation coefficient and normalized root mean square of the difference (nRMSd) between test and template signals). With an electroanatomic mapping system, the correlation coefficient of each pace map was correlated with the distance between the pacing site and the effective ablation site. The endocardial area within the 10-ms activation isochrone was measured. The ablation procedure was effective in all patients. Sites with good pace maps had a higher correlation coefficient and lower nRMSd than sites with inadequate pace maps (correlation coefficient: 0.96 +/- 0.03 vs 0.76 +/- 0.18, P <.0001; nRMSd: 0.41 +/- 0.16 vs 0.89 +/- 0.39, P <.0001). Using receiver operating characteristic curves, appropriate cutoff values were >0.94 for correlation coefficient (sensitivity 81%, specificity 89%) and < or =0.54 for nRMSd (sensitivity 76%, specificity 80%). Good pace maps were located a mean of 7.3 +/- 5.0 mm from the effective ablation site and had a mean activation time of -24 +/- 7 ms. However, in 3 (18%) of 16 patients, the best pace map was inadequate at the effective ablation site, with an endocardial activation time at these sites of -25 +/- 12 ms. Pace maps with correlation coefficient > or =0.94 were confined to an area of 1.8 +/- 0.6 cm2. The 10-ms isochrone measured 1.2 +/- 0.7 cm2. The spatial resolution of a good pace map for targeting ventricular tachycardia/ectopy is 1.8 cm2 in the right ventricular outflow tract and therefore is inferior to the spatial resolution of activation mapping as assessed by isochronal activation. In approximately 20% of patients, pace mapping is unreliable in identifying the site of origin, possibly due a deeper site of origin and preferential conduction via fibers connecting the focus to the endocardial surface.

Two Interrogated FBG Spectral Linewidth for Strain Sensing through Correlation.

PubMed

Hsu, Shih-Hsiang; Chuang, Kuo-Wei; Chen, Ci-Syu; Lin, Ching-Yu; Chang, Che-Chang

2017-12-07

The spectral linewidth from two cross-correlated fiber Bragg gratings (FBGs) are interrogated and characterized using a delayed self-homodyne method for fiber strain sensing. This approach employs a common higher frequency resolution instead of wavelength. A sensitivity and resolution of 166 MHz/με and 50 nε were demonstrated from 4 GHz spectral linewidth characterization on the electric spectrum analyzer. A 10 nε higher resolution can be expected through random noise analyses when the spectral linewidth from two FBG correlations is reduced to 1 GHz. Moreover, the FBG spectrum is broadened during strain and experimentally shows a 0.44 pm/με sensitivity, which is mainly caused by the photo elastic effect from the fiber grating period stretch.

Refinement procedure for the image alignment in high-resolution electron tomography.

PubMed

Houben, L; Bar Sadan, M

2011-01-01

High-resolution electron tomography from a tilt series of transmission electron microscopy images requires an accurate image alignment procedure in order to maximise the resolution of the tomogram. This is the case in particular for ultra-high resolution where even very small misalignments between individual images can dramatically reduce the fidelity of the resultant reconstruction. A tomographic-reconstruction based and marker-free method is proposed, which uses an iterative optimisation of the tomogram resolution. The method utilises a search algorithm that maximises the contrast in tomogram sub-volumes. Unlike conventional cross-correlation analysis it provides the required correlation over a large tilt angle separation and guarantees a consistent alignment of images for the full range of object tilt angles. An assessment based on experimental reconstructions shows that the marker-free procedure is competitive to the reference of marker-based procedures at lower resolution and yields sub-pixel accuracy even for simulated high-resolution data. Copyright © 2011 Elsevier B.V. All rights reserved.

A Microfluidic Platform for Correlative Live-Cell and Super-Resolution Microscopy

PubMed Central

Tam, Johnny; Cordier, Guillaume Alan; Bálint, Štefan; Sandoval Álvarez, Ángel; Borbely, Joseph Steven; Lakadamyali, Melike

2014-01-01

Recently, super-resolution microscopy methods such as stochastic optical reconstruction microscopy (STORM) have enabled visualization of subcellular structures below the optical resolution limit. Due to the poor temporal resolution, however, these methods have mostly been used to image fixed cells or dynamic processes that evolve on slow time-scales. In particular, fast dynamic processes and their relationship to the underlying ultrastructure or nanoscale protein organization cannot be discerned. To overcome this limitation, we have recently developed a correlative and sequential imaging method that combines live-cell and super-resolution microscopy. This approach adds dynamic background to ultrastructural images providing a new dimension to the interpretation of super-resolution data. However, currently, it suffers from the need to carry out tedious steps of sample preparation manually. To alleviate this problem, we implemented a simple and versatile microfluidic platform that streamlines the sample preparation steps in between live-cell and super-resolution imaging. The platform is based on a microfluidic chip with parallel, miniaturized imaging chambers and an automated fluid-injection device, which delivers a precise amount of a specified reagent to the selected imaging chamber at a specific time within the experiment. We demonstrate that this system can be used for live-cell imaging, automated fixation, and immunostaining of adherent mammalian cells in situ followed by STORM imaging. We further demonstrate an application by correlating mitochondrial dynamics, morphology, and nanoscale mitochondrial protein distribution in live and super-resolution images. PMID:25545548

Correlation ion mobility spectroscopy

DOEpatents

Pfeifer, Kent B [Los Lunas, NM; Rohde, Steven B [Corrales, NM

2008-08-26

Correlation ion mobility spectrometry (CIMS) uses gating modulation and correlation signal processing to improve IMS instrument performance. Closely spaced ion peaks can be resolved by adding discriminating codes to the gate and matched filtering for the received ion current signal, thereby improving sensitivity and resolution of an ion mobility spectrometer. CIMS can be used to improve the signal-to-noise ratio even for transient chemical samples. CIMS is especially advantageous for small geometry IMS drift tubes that can otherwise have poor resolution due to their small size.

Initial Data of Digital Correlation ECE with a Giga Hertz Sampling Digitizer

NASA Astrophysics Data System (ADS)

Tsuchiya, Hayato; Inagaki, Shigeru; Tokuzawa, Tokihiko; Nagayama, Yoshio

2015-03-01

The proposed Digital Correlation ECE (DCECE) technique is applied in Large Helical Device. DCECE is realized by the use of the Giga Hertz Sampling Digitizer. The waveform of intermediate frequency band of ECE, whose frequency is several giga hertz, can be discretized and saved directly. The discretized IF data can be used for the analysis of correlation ECE with arbitrary parameter of spatial resolution and temporal resolution. In this paper, the characteristic of DCECE and initial Data in LHD is introduced.

Exploring the Potential of PROBA-V for Evapotranspiration Monitoring in Wetlands

NASA Astrophysics Data System (ADS)

Barrios, Jose Miguel; Ghilain, Nicolas; Arboleda, Alirio; Gellens-Meulenberghs, Francoise

2016-08-01

This study aims at deriving daily evapotranspiration (ET) estimates at a convenient spatial resolution for ecosystem monitoring. The methodological approach was based on the computation of the energy balance over the study sites. The study explored the potential of integrating remote sensing (RS) products derived from the Meteosat Second Generation (MSG) satellite -in virtue of their high temporal resolution- and Proba-V data, supplying moderate spatial resolution data. This strategy was tested for the year 2014 on three wetlands sites located in Europe where eddy covariance measurements were available for validation. The modelled results correlated well with the validation data and showed the added value of combining the strengths of different satellite missions. The results open interesting perspectives for refining this approach with the upcoming Sentinel-3 datasets.

Influence of imaging resolution on color fidelity in digital archiving.

PubMed

Zhang, Pengchang; Toque, Jay Arre; Ide-Ektessabi, Ari

2015-11-01

Color fidelity is of paramount importance in digital archiving. In this paper, the relationship between color fidelity and imaging resolution was explored by calculating the color difference of an IT8.7/2 color chart with a CIELAB color difference formula for scanning and simulation images. Microscopic spatial sampling was used in selecting the image pixels for the calculations to highlight the loss of color information. A ratio, called the relative imaging definition (RID), was defined to express the correlation between image resolution and color fidelity. The results show that in order for color differences to remain unrecognizable, the imaging resolution should be at least 10 times higher than the physical dimension of the smallest feature in the object being studied.

Achieving subpixel resolution with time-correlated transient signals in pixelated CdZnTe gamma-ray sensors using a focused laser beam (Conference Presentation)

NASA Astrophysics Data System (ADS)

Ocampo Giraldo, Luis A.; Bolotnikov, Aleksey E.; Camarda, Giuseppe S.; Cui, Yonggang; De Geronimo, Gianluigi; Gul, Rubi; Fried, Jack; Hossain, Anwar; Unlu, Kenan; Vernon, Emerson; Yang, Ge; James, Ralph B.

2017-05-01

High-resolution position-sensitive detectors have been proposed to correct response non-uniformities in Cadmium Zinc Telluride (CZT) crystals by virtually subdividing the detectors area into small voxels and equalizing responses from each voxel. 3D pixelated detectors coupled with multichannel readout electronics are the most advanced type of CZT devices offering many options in signal processing and enhancing detector performance. One recent innovation proposed for pixelated detectors is to use the induced (transient) signals from neighboring pixels to achieve high sub-pixel position resolution while keeping large pixel sizes. The main hurdle in achieving this goal is the relatively low signal induced on the neighboring pixels because of the electrostatic shielding effect caused by the collecting pixel. In addition, to achieve high position sensitivity one should rely on time-correlated transient signals, which means that digitized output signals must be used. We present the results of our studies to measure the amplitude of the pixel signals so that these can be used to measure positions of the interaction points. This is done with the processing of digitized correlated time signals measured from several adjacent pixels taking into account rise-time and charge-sharing effects. In these measurements we used a focused pulsed laser to generate a 10-micron beam at one milliwatt (650-nm wavelength) over the detector surface while the collecting pixel was moved in cardinal directions. The results include measurements that present the benefits of combining conventional pixel geometry with digital pulse processing for the best approach in achieving sub-pixel position resolution with the pixel dimensions of approximately 2 mm. We also present the sub-pixel resolution measurements at comparable energies from various gamma emitting isotopes.

Sediment delivery modeling in practice: Comparing the effects of watershed characteristics and data resolution across hydroclimatic regions.

PubMed

Hamel, Perrine; Falinski, Kim; Sharp, Richard; Auerbach, Daniel A; Sánchez-Canales, María; Dennedy-Frank, P James

2017-02-15

Geospatial models are commonly used to quantify sediment contributions at the watershed scale. However, the sensitivity of these models to variation in hydrological and geomorphological features, in particular to land use and topography data, remains uncertain. Here, we assessed the performance of one such model, the InVEST sediment delivery model, for six sites comprising a total of 28 watersheds varying in area (6-13,500km 2 ), climate (tropical, subtropical, mediterranean), topography, and land use/land cover. For each site, we compared uncalibrated and calibrated model predictions with observations and alternative models. We then performed correlation analyses between model outputs and watershed characteristics, followed by sensitivity analyses on the digital elevation model (DEM) resolution. Model performance varied across sites (overall r 2 =0.47), but estimates of the magnitude of specific sediment export were as or more accurate than global models. We found significant correlations between metrics of sediment delivery and watershed characteristics, including erosivity, suggesting that empirical relationships may ultimately be developed for ungauged watersheds. Model sensitivity to DEM resolution varied across and within sites, but did not correlate with other observed watershed variables. These results were corroborated by sensitivity analyses performed on synthetic watersheds ranging in mean slope and DEM resolution. Our study provides modelers using InVEST or similar geospatial sediment models with practical insights into model behavior and structural uncertainty: first, comparison of model predictions across regions is possible when environmental conditions differ significantly; second, local knowledge on the sediment budget is needed for calibration; and third, model outputs often show significant sensitivity to DEM resolution. Copyright © 2016 Elsevier B.V. All rights reserved.

Clinical progression and outcome of dysphagia following paediatric traumatic brain injury: a prospective study.

PubMed

Morgan, Angela; Ward, Elizabeth; Murdoch, Bruce

2004-04-01

To provide a preliminary clinical profile of the resolution and outcomes of oral-motor impairment and swallowing function in a group of paediatric dysphagia patients post-traumatic brain injury (TBI). To document the level of cognitive impairment parallel to the return to oral intake, and to investigate the correlation between the resolution of impaired swallow function versus the resolution of oral-motor impairment and cognitive impairment. Thirteen children admitted to an acute care setting for TBI. A series of oral-motor (Verbal Motor Production Assessment for Children, Frenchay Dysarthria Assessment, Schedule for Oral Motor Assessment) and swallowing (Paramatta Hospital's Assessment for Dysphagia) assessments, an outcome measure for swallowing (Royal Brisbane Hospital's Outcome Measure for Swallowing), and a cognitive rating scale (Rancho Level of Cognitive Functioning Scale). Across the patient group, oral-motor deficits resolved to normal status between 3 and 11 weeks post-referral (and at an average of 12 weeks post-injury) and swallowing function and resolution to normal diet status were achieved by 3-11 weeks post-referral (and at an average of 12 weeks post-injury). The resolution of dysphagia and the resolution of oral-motor impairment and cognitive impairment were all highly correlated. The provision of a preliminary profile of oral-motor functioning and dysphagia resolution, and data on the linear relationship between swallowing impairment and cognition, will provide baseline information on the course of rehabilitation of dysphagia in the paediatric population post-TBI. Such data will contribute to more informed service provision and rehabilitation planning for paediatric patients post-TBI.

Importance of conduction electron correlation in a Kondo lattice, Ce₂CoSi₃.

PubMed

Patil, Swapnil; Pandey, Sudhir K; Medicherla, V R R; Singh, R S; Bindu, R; Sampathkumaran, E V; Maiti, Kalobaran

2010-06-30

Kondo systems are usually described by the interaction of the correlation induced local moments with the highly itinerant conduction electrons. Here, we study the role of electron correlations among conduction electrons in the electronic structure of a Kondo lattice compound, Ce₂CoSi₃, using high resolution photoemission spectroscopy and ab initio band structure calculations, where Co 3d electrons contribute in the conduction band. High energy resolution employed in the measurements helped to reveal the signatures of Ce 4f states derived Kondo resonance features at the Fermi level and the dominance of Co 3d contributions at higher binding energies in the conduction band. The lineshape of the experimental Co 3d band is found to be significantly different from that obtained from the band structure calculations within the local density approximations, LDA. Consideration of electron-electron Coulomb repulsion, U, among Co 3d electrons within the LDA + U method leads to a better representation of experimental results. The signature of an electron correlation induced satellite feature is also observed in the Co 2p core level spectrum. These results clearly demonstrate the importance of the electron correlation among conduction electrons in deriving the microscopic description of such Kondo systems.

Correlative fluorescence microscopy and scanning transmission electron microscopy of quantum-dot-labeled proteins in whole cells in liquid.

PubMed

Dukes, Madeline J; Peckys, Diana B; de Jonge, Niels

2010-07-27

Correlative fluorescence microscopy and transmission electron microscopy (TEM) is a state-of-the-art microscopy methodology to study cellular function, combining the functionality of light microscopy with the high resolution of electron microscopy. However, this technique involves complex sample preparation procedures due to its need for either thin sections or frozen samples for TEM imaging. Here, we introduce a novel correlative approach capable of imaging whole eukaryotic cells in liquid with fluorescence microscopy and with scanning transmission electron microscopy (STEM); there is no additional sample preparation necessary for the electron microscopy. Quantum dots (QDs) were bound to epidermal growth factor (EGF) receptors of COS7 fibroblast cells. Fixed whole cells in saline water were imaged with fluorescence microscopy and subsequently with STEM. The STEM images were correlated with fluorescence images of the same cellular regions. QDs of dimensions 7x12 nm were visible in a 5 microm thick layer of saline water, consistent with calculations. A spatial resolution of 3 nm was achieved on the QDs.

Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Correlate With Electroencephalography Parameters Assessed by Exact Low-Resolution Electromagnetic Tomography (eLORETA).

PubMed

Hata, Masahiro; Tanaka, Toshihisa; Kazui, Hiroaki; Ishii, Ryouhei; Canuet, Leonides; Pascual-Marqui, Roberto D; Aoki, Yasunori; Ikeda, Shunichiro; Sato, Shunsuke; Suzuki, Yukiko; Kanemoto, Hideki; Yoshiyama, Kenji; Iwase, Masao

2017-09-01

Recently, cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease (AD) have garnered a lot of clinical attention. To explore neurophysiological traits of AD and parameters for its clinical diagnosis, we examined the association between CSF biomarkers and electroencephalography (EEG) parameters in 14 probable AD patients. Using exact low-resolution electromagnetic tomography (eLORETA), artifact-free 40-sesond EEG data were estimated with current source density (CSD) and lagged phase synchronization (LPS) as the EEG parameters. Correlations between CSF biomarkers and the EEG parameters were assessed. Patients with AD showed significant negative correlation between CSF beta-amyloid (Aβ)-42 concentration and the logarithms of CSD over the right temporal area in the theta band. Total tau concentration was negatively correlated with the LPS between the left frontal eye field and the right auditory area in the alpha-2 band in patients with AD. Our study results suggest that AD biomarkers, in particular CSF Aβ42 and total tau concentrations are associated with the EEG parameters CSD and LPS, respectively. Our results could yield more insights into the complicated pathology of AD.

Correlative Fluorescence Microscopy and Scanning Transmission Electron Microscopy of Quantum Dot Labeled Proteins in Whole Cells in Liquid

PubMed Central

Dukes, Madeline J.; Peckys, Diana B.; de Jonge, Niels

2010-01-01

Correlative fluorescence microscopy and transmission electron microscopy (TEM) is a state-of-the-art microscopy methodology to study cellular function, combining the functionality of light microscopy with the high resolution of electron microscopy. However, this technique involves complex sample preparation procedures due to its need for either thin sections or frozen samples for TEM imaging. Here, we introduce a novel correlative approach capable of imaging whole eukaryotic cells in liquid with fluorescence microscopy and with scanning transmission electron microscopy (STEM); there is no additional sample preparation necessary for the electron microscopy. Quantum dots (QDs) were bound to epidermal growth factor (EGF) receptors of COS7 fibroblast cells. Fixed whole cells in saline water were imaged with fluorescence microscopy and subsequently with STEM. The STEM images were correlated with fluorescence images of the same cellular regions. QDs of dimensions 7 × 12 nm were visible in a 5 μm thick layer of saline water, consistent with calculations. A spatial resolution of 3 nm was achieved on the QDs. PMID:20550177

Study of sub-pixel position resolution with time-correlated transient signals in 3D pixelated CdZnTe detectors with varying pixel sizes

NASA Astrophysics Data System (ADS)

Ocampo Giraldo, L.; Bolotnikov, A. E.; Camarda, G. S.; De Geronimo, G.; Fried, J.; Gul, R.; Hodges, D.; Hossain, A.; Ünlü, K.; Vernon, E.; Yang, G.; James, R. B.

2018-03-01

We evaluated the sub-pixel position resolution achievable in large-volume CdZnTe pixelated detectors with conventional pixel patterns and for several different pixel sizes: 2.8 mm, 1.72 mm, 1.4 mm and 0.8 mm. Achieving position resolution below the physical dimensions of pixels (sub-pixel resolution) is a practical path for making high-granularity position-sensitive detectors, <100 μm, using a limited number of pixels dictated by the mechanical constraints and multi-channel readout electronics. High position sensitivity is important for improving the imaging capability of CZT gamma cameras. It also allows for making more accurate corrections of response non-uniformities caused by crystal defects, thus enabling use of standard-grade (unselected) and less expensive CZT crystals for producing large-volume position-sensitive CZT detectors feasible for many practical applications. We analyzed the digitized charge signals from a representative 9 pixels and the cathode, generated using a pulsed-laser light beam focused down to 10 μm (650 nm) to scan over a selected 3 × 3 pixel area. We applied our digital pulse processing technique to the time-correlated signals captured from adjacent pixels to achieve and evaluate the capability for sub-pixel position resolution. As an example, we also demonstrated an application of 3D corrections to improve the energy resolution and positional information of the events for the tested detectors.

Study of sub-pixel position resolution with time-correlated transient signals in 3D pixelated CdZnTe detectors with varying pixel sizes

DOE PAGES

Giraldo, L. Ocampo; Bolotnikov, A. E.; Camarda, G. S.; ...

2017-12-18

Here, we evaluated the sub-pixel position resolution achievable in large-volume CdZnTe pixelated detectors with conventional pixel patterns and for several different pixel sizes: 2.8 mm, 1.72 mm, 1.4 mm and 0.8 mm. Achieving position resolution below the physical dimensions of pixels (sub-pixel resolution) is a practical path for making high-granularity position-sensitive detectors, <100 μμm, using a limited number of pixels dictated by the mechanical constraints and multi-channel readout electronics. High position sensitivity is important for improving the imaging capability of CZT gamma cameras. It also allows for making more accurate corrections of response non-uniformities caused by crystal defects, thus enablingmore » use of standard-grade (unselected) and less expensive CZT crystals for producing large-volume position-sensitive CZT detectors feasible for many practical applications. We analyzed the digitized charge signals from a representative 9 pixels and the cathode, generated using a pulsed-laser light beam focused down to 10 m (650 nm) to scan over a selected 3×3 pixel area. We applied our digital pulse processing technique to the time-correlated signals captured from adjacent pixels to achieve and evaluate the capability for sub-pixel position resolution. As an example, we also demonstrated an application of 3D corrections to improve the energy resolution and positional information of the events for the tested detectors.« less

Study of sub-pixel position resolution with time-correlated transient signals in 3D pixelated CdZnTe detectors with varying pixel sizes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giraldo, L. Ocampo; Bolotnikov, A. E.; Camarda, G. S.

Here, we evaluated the sub-pixel position resolution achievable in large-volume CdZnTe pixelated detectors with conventional pixel patterns and for several different pixel sizes: 2.8 mm, 1.72 mm, 1.4 mm and 0.8 mm. Achieving position resolution below the physical dimensions of pixels (sub-pixel resolution) is a practical path for making high-granularity position-sensitive detectors, <100 μμm, using a limited number of pixels dictated by the mechanical constraints and multi-channel readout electronics. High position sensitivity is important for improving the imaging capability of CZT gamma cameras. It also allows for making more accurate corrections of response non-uniformities caused by crystal defects, thus enablingmore » use of standard-grade (unselected) and less expensive CZT crystals for producing large-volume position-sensitive CZT detectors feasible for many practical applications. We analyzed the digitized charge signals from a representative 9 pixels and the cathode, generated using a pulsed-laser light beam focused down to 10 m (650 nm) to scan over a selected 3×3 pixel area. We applied our digital pulse processing technique to the time-correlated signals captured from adjacent pixels to achieve and evaluate the capability for sub-pixel position resolution. As an example, we also demonstrated an application of 3D corrections to improve the energy resolution and positional information of the events for the tested detectors.« less

Functional inverted Wishart for Bayesian multivariate spatial modeling with application to regional climatology model data.

PubMed

Duan, L L; Szczesniak, R D; Wang, X

2017-11-01

Modern environmental and climatological studies produce multiple outcomes at high spatial resolutions. Multivariate spatial modeling is an established means to quantify cross-correlation among outcomes. However, existing models typically suffer from poor computational efficiency and lack the flexibility to simultaneously estimate auto- and cross-covariance structures. In this article, we undertake a novel construction of covariance by utilizing spectral convolution and by imposing an inverted Wishart prior on the cross-correlation structure. The cross-correlation structure with this functional inverted Wishart prior flexibly accommodates not only positive but also weak or negative associations among outcomes while preserving spatial resolution. Furthermore, the proposed model is computationally efficient and produces easily interpretable results, including the individual autocovariances and full cross-correlation matrices, as well as a partial cross-correlation matrix reflecting the outcome correlation after excluding the effects caused by spatial convolution. The model is examined using simulated data sets under different scenarios. It is also applied to the data from the North American Regional Climate Change Assessment Program, examining long-term associations between surface outcomes for air temperature, pressure, humidity, and radiation, on the land area of the North American West Coast. Results and predictive performance are compared with findings from approaches using convolution only or coregionalization.

Functional inverted Wishart for Bayesian multivariate spatial modeling with application to regional climatology model data

PubMed Central

Duan, L. L.; Szczesniak, R. D.; Wang, X.

2018-01-01

Modern environmental and climatological studies produce multiple outcomes at high spatial resolutions. Multivariate spatial modeling is an established means to quantify cross-correlation among outcomes. However, existing models typically suffer from poor computational efficiency and lack the flexibility to simultaneously estimate auto- and cross-covariance structures. In this article, we undertake a novel construction of covariance by utilizing spectral convolution and by imposing an inverted Wishart prior on the cross-correlation structure. The cross-correlation structure with this functional inverted Wishart prior flexibly accommodates not only positive but also weak or negative associations among outcomes while preserving spatial resolution. Furthermore, the proposed model is computationally efficient and produces easily interpretable results, including the individual autocovariances and full cross-correlation matrices, as well as a partial cross-correlation matrix reflecting the outcome correlation after excluding the effects caused by spatial convolution. The model is examined using simulated data sets under different scenarios. It is also applied to the data from the North American Regional Climate Change Assessment Program, examining long-term associations between surface outcomes for air temperature, pressure, humidity, and radiation, on the land area of the North American West Coast. Results and predictive performance are compared with findings from approaches using convolution only or coregionalization. PMID:29576735

Conflict Resolution between Mexican Origin Adolescent Siblings

ERIC Educational Resources Information Center

Killoren, Sarah E.; Thayer, Shawna M.; Updegraff, Kimberly A.

2008-01-01

We investigated correlates of adolescents' sibling conflict resolution strategies in 246, two-parent Mexican origin families. Specifically, we examined links between siblings' conflict resolution strategies and sibling dyad characteristics, siblings' cultural orientations and values, and sibling relationship qualities. Data were gathered during…

Correlated components of ongoing EEG point to emotionally laden attention - a possible marker of engagement?

PubMed

Dmochowski, Jacek P; Sajda, Paul; Dias, Joao; Parra, Lucas C

2012-01-01

Recent evidence from functional magnetic resonance imaging suggests that cortical hemodynamic responses coincide in different subjects experiencing a common naturalistic stimulus. Here we utilize neural responses in the electroencephalogram (EEG) evoked by multiple presentations of short film clips to index brain states marked by high levels of correlation within and across subjects. We formulate a novel signal decomposition method which extracts maximally correlated signal components from multiple EEG records. The resulting components capture correlations down to a one-second time resolution, thus revealing that peak correlations of neural activity across viewings can occur in remarkable correspondence with arousing moments of the film. Moreover, a significant reduction in neural correlation occurs upon a second viewing of the film or when the narrative is disrupted by presenting its scenes scrambled in time. We also probe oscillatory brain activity during periods of heightened correlation, and observe during such times a significant increase in the theta band for a frontal component and reductions in the alpha and beta frequency bands for parietal and occipital components. Low-resolution EEG tomography of these components suggests that the correlated neural activity is consistent with sources in the cingulate and orbitofrontal cortices. Put together, these results suggest that the observed synchrony reflects attention- and emotion-modulated cortical processing which may be decoded with high temporal resolution by extracting maximally correlated components of neural activity.

Correlated Components of Ongoing EEG Point to Emotionally Laden Attention – A Possible Marker of Engagement?

PubMed Central

Dmochowski, Jacek P.; Sajda, Paul; Dias, Joao; Parra, Lucas C.

2012-01-01

Recent evidence from functional magnetic resonance imaging suggests that cortical hemodynamic responses coincide in different subjects experiencing a common naturalistic stimulus. Here we utilize neural responses in the electroencephalogram (EEG) evoked by multiple presentations of short film clips to index brain states marked by high levels of correlation within and across subjects. We formulate a novel signal decomposition method which extracts maximally correlated signal components from multiple EEG records. The resulting components capture correlations down to a one-second time resolution, thus revealing that peak correlations of neural activity across viewings can occur in remarkable correspondence with arousing moments of the film. Moreover, a significant reduction in neural correlation occurs upon a second viewing of the film or when the narrative is disrupted by presenting its scenes scrambled in time. We also probe oscillatory brain activity during periods of heightened correlation, and observe during such times a significant increase in the theta band for a frontal component and reductions in the alpha and beta frequency bands for parietal and occipital components. Low-resolution EEG tomography of these components suggests that the correlated neural activity is consistent with sources in the cingulate and orbitofrontal cortices. Put together, these results suggest that the observed synchrony reflects attention- and emotion-modulated cortical processing which may be decoded with high temporal resolution by extracting maximally correlated components of neural activity. PMID:22623915

The study on the parallel processing based time series correlation analysis of RBC membrane flickering in quantitative phase imaging

NASA Astrophysics Data System (ADS)

Lee, Minsuk; Won, Youngjae; Park, Byungjun; Lee, Seungrag

2017-02-01

Not only static characteristics but also dynamic characteristics of the red blood cell (RBC) contains useful information for the blood diagnosis. Quantitative phase imaging (QPI) can capture sample images with subnanometer scale depth resolution and millisecond scale temporal resolution. Various researches have been used QPI for the RBC diagnosis, and recently many researches has been developed to decrease the process time of RBC information extraction using QPI by the parallel computing algorithm, however previous studies are interested in the static parameters such as morphology of the cells or simple dynamic parameters such as root mean square (RMS) of the membrane fluctuations. Previously, we presented a practical blood test method using the time series correlation analysis of RBC membrane flickering with QPI. However, this method has shown that there is a limit to the clinical application because of the long computation time. In this study, we present an accelerated time series correlation analysis of RBC membrane flickering using the parallel computing algorithm. This method showed consistent fractal scaling exponent results of the surrounding medium and the normal RBC with our previous research.

Crack nucleation using combined crystal plasticity modelling, high-resolution digital image correlation and high-resolution electron backscatter diffraction in a superalloy containing non-metallic inclusions under fatigue

PubMed Central

Zhang, Tiantian; Britton, Ben; Shollock, Barbara; Dunne, Fionn

2016-01-01

A crystal plasticity finite-element model, which explicitly and directly represents the complex microstructures of a non-metallic agglomerate inclusion within polycrystal nickel alloy, has been developed to study the mechanistic basis of fatigue crack nucleation. The methodology is to use the crystal plasticity model in conjunction with direct measurement at the microscale using high (angular) resolution-electron backscatter diffraction (HR-EBSD) and high (spatial) resolution-digital image correlation (HR-DIC) strain measurement techniques. Experimentally, this sample has been subjected to heat treatment leading to the establishment of residual (elastic) strains local to the agglomerate and subsequently loaded under conditions of low cyclic fatigue. The full thermal and mechanical loading history was reproduced within the model. HR-EBSD and HR-DIC elastic and total strain measurements demonstrate qualitative and quantitative agreement with crystal plasticity results. Crack nucleation by interfacial decohesion at the nickel matrix/agglomerate inclusion boundaries is observed experimentally, and systematic modelling studies enable the mechanistic basis of the nucleation to be established. A number of fatigue crack nucleation indicators are also assessed against the experimental results. Decohesion was found to be driven by interface tensile normal stress alone, and the interfacial strength was determined to be in the range of 1270–1480 MPa. PMID:27279765

Crack nucleation using combined crystal plasticity modelling, high-resolution digital image correlation and high-resolution electron backscatter diffraction in a superalloy containing non-metallic inclusions under fatigue

NASA Astrophysics Data System (ADS)

Zhang, Tiantian; Jiang, Jun; Britton, Ben; Shollock, Barbara; Dunne, Fionn

2016-05-01

A crystal plasticity finite-element model, which explicitly and directly represents the complex microstructures of a non-metallic agglomerate inclusion within polycrystal nickel alloy, has been developed to study the mechanistic basis of fatigue crack nucleation. The methodology is to use the crystal plasticity model in conjunction with direct measurement at the microscale using high (angular) resolution-electron backscatter diffraction (HR-EBSD) and high (spatial) resolution-digital image correlation (HR-DIC) strain measurement techniques. Experimentally, this sample has been subjected to heat treatment leading to the establishment of residual (elastic) strains local to the agglomerate and subsequently loaded under conditions of low cyclic fatigue. The full thermal and mechanical loading history was reproduced within the model. HR-EBSD and HR-DIC elastic and total strain measurements demonstrate qualitative and quantitative agreement with crystal plasticity results. Crack nucleation by interfacial decohesion at the nickel matrix/agglomerate inclusion boundaries is observed experimentally, and systematic modelling studies enable the mechanistic basis of the nucleation to be established. A number of fatigue crack nucleation indicators are also assessed against the experimental results. Decohesion was found to be driven by interface tensile normal stress alone, and the interfacial strength was determined to be in the range of 1270-1480 MPa.

Combining HJ CCD, GF-1 WFV and MODIS Data to Generate Daily High Spatial Resolution Synthetic Data for Environmental Process Monitoring.

PubMed

Wu, Mingquan; Huang, Wenjiang; Niu, Zheng; Wang, Changyao

2015-08-20

The limitations of satellite data acquisition mean that there is a lack of satellite data with high spatial and temporal resolutions for environmental process monitoring. In this study, we address this problem by applying the Enhanced Spatial and Temporal Adaptive Reflectance Fusion Model (ESTARFM) and the Spatial and Temporal Data Fusion Approach (STDFA) to combine Huanjing satellite charge coupled device (HJ CCD), Gaofen satellite no. 1 wide field of view camera (GF-1 WFV) and Moderate Resolution Imaging Spectroradiometer (MODIS) data to generate daily high spatial resolution synthetic data for land surface process monitoring. Actual HJ CCD and GF-1 WFV data were used to evaluate the precision of the synthetic images using the correlation analysis method. Our method was tested and validated for two study areas in Xinjiang Province, China. The results show that both the ESTARFM and STDFA can be applied to combine HJ CCD and MODIS reflectance data, and GF-1 WFV and MODIS reflectance data, to generate synthetic HJ CCD data and synthetic GF-1 WFV data that closely match actual data with correlation coefficients (r) greater than 0.8989 and 0.8643, respectively. Synthetic red- and near infrared (NIR)-band data generated by ESTARFM are more suitable for the calculation of Normalized Different Vegetation Index (NDVI) than the data generated by STDFA.

Combining HJ CCD, GF-1 WFV and MODIS Data to Generate Daily High Spatial Resolution Synthetic Data for Environmental Process Monitoring

PubMed Central

Wu, Mingquan; Huang, Wenjiang; Niu, Zheng; Wang, Changyao

2015-01-01

The limitations of satellite data acquisition mean that there is a lack of satellite data with high spatial and temporal resolutions for environmental process monitoring. In this study, we address this problem by applying the Enhanced Spatial and Temporal Adaptive Reflectance Fusion Model (ESTARFM) and the Spatial and Temporal Data Fusion Approach (STDFA) to combine Huanjing satellite charge coupled device (HJ CCD), Gaofen satellite no. 1 wide field of view camera (GF-1 WFV) and Moderate Resolution Imaging Spectroradiometer (MODIS) data to generate daily high spatial resolution synthetic data for land surface process monitoring. Actual HJ CCD and GF-1 WFV data were used to evaluate the precision of the synthetic images using the correlation analysis method. Our method was tested and validated for two study areas in Xinjiang Province, China. The results show that both the ESTARFM and STDFA can be applied to combine HJ CCD and MODIS reflectance data, and GF-1 WFV and MODIS reflectance data, to generate synthetic HJ CCD data and synthetic GF-1 WFV data that closely match actual data with correlation coefficients (r) greater than 0.8989 and 0.8643, respectively. Synthetic red- and near infrared (NIR)-band data generated by ESTARFM are more suitable for the calculation of Normalized Different Vegetation Index (NDVI) than the data generated by STDFA. PMID:26308017

Probing the Inelastic Interactions in Molecular Junctions by Scanning Tunneling Microscope

NASA Astrophysics Data System (ADS)

Xu, Chen

With a sub-Kelvin scanning tunneling microscope, the energy resolution of spectroscopy is improved dramatically. Detailed studies of finer features of spectrum become possible. The asymmetry in the line shape of carbon monoxide vibrational spectra is observed to correlate with the couplings of the molecule to the tip and substrates. The spin-vibronic coupling in the molecular junctions is revisited with two metal phthalocyanine molecules, unveiling sharp spin-vibronic peaks. Finally, thanks to the improved spectrum resolution, the bonding structure of the acyclic compounds molecules is surveyed with STM inelastic tunneling probe, expanding the capability of the innovative high resolution imaging technique.

Temporal and spectral manipulations of correlated photons using a time lens

NASA Astrophysics Data System (ADS)

Mittal, Sunil; Orre, Venkata Vikram; Restelli, Alessandro; Salem, Reza; Goldschmidt, Elizabeth A.; Hafezi, Mohammad

2017-10-01

A common challenge in quantum information processing with photons is the limited ability to manipulate and measure correlated states. An example is the inability to measure picosecond-scale temporal correlations of a multiphoton state, given state-of-the-art detectors have a temporal resolution of about 100 ps. Here, we demonstrate temporal magnification of time-bin-entangled two-photon states using a time lens and measure their temporal correlation function, which is otherwise not accessible because of the limited temporal resolution of single-photon detectors. Furthermore, we show that the time lens maps temporal correlations of photons to frequency correlations and could be used to manipulate frequency-bin-entangled photons. This demonstration opens a new avenue to manipulate and analyze spectral and temporal wave functions of many-photon states.

Parameterizing the Spatial Markov Model from Breakthrough Curve Data Alone

NASA Astrophysics Data System (ADS)

Sherman, T.; Bolster, D.; Fakhari, A.; Miller, S.; Singha, K.

2017-12-01

The spatial Markov model (SMM) uses a correlated random walk and has been shown to effectively capture anomalous transport in porous media systems; in the SMM, particles' future trajectories are correlated to their current velocity. It is common practice to use a priori Lagrangian velocity statistics obtained from high resolution simulations to determine a distribution of transition probabilities (correlation) between velocity classes that govern predicted transport behavior; however, this approach is computationally cumbersome. Here, we introduce a methodology to quantify velocity correlation from Breakthrough (BTC) curve data alone; discretizing two measured BTCs into a set of arrival times and reverse engineering the rules of the SMM allows for prediction of velocity correlation, thereby enabling parameterization of the SMM in studies where Lagrangian velocity statistics are not available. The introduced methodology is applied to estimate velocity correlation from BTCs measured in high resolution simulations, thus allowing for a comparison of estimated parameters with known simulated values. Results show 1) estimated transition probabilities agree with simulated values and 2) using the SMM with estimated parameterization accurately predicts BTCs downstream. Additionally, we include uncertainty measurements by calculating lower and upper estimates of velocity correlation, which allow for prediction of a range of BTCs. The simulated BTCs fall in the range of predicted BTCs. This research proposes a novel method to parameterize the SMM from BTC data alone, thereby reducing the SMM's computational costs and widening its applicability.

EIT image reconstruction with four dimensional regularization.

PubMed

Dai, Tao; Soleimani, Manuchehr; Adler, Andy

2008-09-01

Electrical impedance tomography (EIT) reconstructs internal impedance images of the body from electrical measurements on body surface. The temporal resolution of EIT data can be very high, although the spatial resolution of the images is relatively low. Most EIT reconstruction algorithms calculate images from data frames independently, although data are actually highly correlated especially in high speed EIT systems. This paper proposes a 4-D EIT image reconstruction for functional EIT. The new approach is developed to directly use prior models of the temporal correlations among images and 3-D spatial correlations among image elements. A fast algorithm is also developed to reconstruct the regularized images. Image reconstruction is posed in terms of an augmented image and measurement vector which are concatenated from a specific number of previous and future frames. The reconstruction is then based on an augmented regularization matrix which reflects the a priori constraints on temporal and 3-D spatial correlations of image elements. A temporal factor reflecting the relative strength of the image correlation is objectively calculated from measurement data. Results show that image reconstruction models which account for inter-element correlations, in both space and time, show improved resolution and noise performance, in comparison to simpler image models.

Study on diagnosis of micro-biomechanical structure using optical coherence tomography

NASA Astrophysics Data System (ADS)

Saeki, Souichi; Hashimoto, Youhei; Saito, Takashi; Hiro, Takafumi; Matsuzaki, Masunori

2007-02-01

Acute coronary syndromes, e.g. myocardial infarctions, are caused by the rupture of unstable plaques on coronary arteries. The stability of plaque, which depends on biomechanical properties of fibrous cap, should be diagnosed crucially. Recently, Optical Coherence Tomography (OCT) has been developed as a cross-sectional imaging method of microstructural biological tissue with high resolution 1~10 μm. Multi-functional OCT system has been promising, e.g. an estimator of biomechanical characteristics. It has been, however, difficult to estimate biomechanical characteristics, because OCT images have just speckle patterns by back-scattering light from tissue. In this study, presented is Optical Coherence Straingraphy (OCS) on the basis of OCT system, which can diagnose tissue strain distribution. This is basically composed of Recursive Cross-correlation technique (RC), which can provide a displacement vector distribution with high resolution. Furthermore, Adjacent Cross-correlation Multiplication (ACM) is introduced as a speckle noise reduction method. Multiplying adjacent correlation maps can eliminate anomalies from speckle noise, and then can enhance S/N in the determination of maximum correlation coefficient. Error propagation also can be further prevented by introducing to the recursive algorithm (RC). In addition, the spatial vector interpolation by local least square method is introduced to remove erroneous vectors and smooth the vector distribution. This was numerically applied to compressed elastic heterogeneous tissue samples to carry out the accuracy verifications. Consequently, it was quantitatively confirmed that its accuracy of displacement vectors and strain matrix components could be enhanced, comparing with the conventional method. Therefore, the proposed method was validated by the identification of different elastic objects with having nearly high resolution for that defined by optical system.

Study on Site Conditions Based on Topographic Slope

NASA Astrophysics Data System (ADS)

Wu, X.; Wang, X.; Yuan, X.; Chen, M.; Dou, A.

2018-04-01

The travel-time averaged shear-wave velocity to a depth of 30m (Vs30) below the Earth's surface is widely used to classify sites in many building codes. Vs30 is also used to estimate site classification in recent ground-motion prediction equations (GMPEs), and the distribution of Vs30 has been mapped in a region or country. An alternative method has recently been proposed for evaluating global seismic site conditions or Vs30, from the SRTM (Shuttle Radar Topography Mission) DEMs (digital elevation models). The basic premise of the method is that the topographic slope can be used as a reliable proxy for Vs30 in the absence of geologically and geotechnically based site-condition maps through correlations between Vs30 measurements and topographic gradient. Here, we use different resolutions (3 arcsec, 30 arcsec) DEM data to get Vs30 data separately, analyze and compare the difference of Vs30 data and site conditions obtained from different resolution DEM data. Shandong Province in eastern China and Sichuan Province in Western China are studied respectively. It is found that the higher resolution data is better at defining spatial topographic features than the 30c data, but less improvement in its correlation with Vs30.

Seasonal monitoring and estimation of regional aerosol distribution over Po valley, northern Italy, using a high-resolution MAIAC product

NASA Astrophysics Data System (ADS)

Arvani, Barbara; Pierce, R. Bradley; Lyapustin, Alexei I.; Wang, Yujie; Ghermandi, Grazia; Teggi, Sergio

2016-09-01

In this work, the new 1 km-resolved Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm is employed to characterize seasonal PM10 - AOD correlations over northern Italy. The accuracy of the new dataset is assessed compared to the widely used Moderate Resolution Imaging Spectroradiometer (MODIS) Collection 5.1 Aerosol Optical Depth (AOD) data, retrieved at 0.55 μm with spatial resolution of 10 km (MYD04_L2). We focused on evaluating the ability of these two products to characterize both temporal and spatial distributions of aerosols within urban and suburban areas. Ground PM10 measurements were obtained from 73 of the Italian Regional Agency for Environmental Protection (ARPA) monitoring stations, spread across northern Italy, during a three-year period from 2010 to 2012. The Po Valley area (northern Italy) was chosen as the study domain because of its severe urban air pollution, resulting from it having the highest population and industrial manufacturing density in the country, being located in a valley where two surrounding mountain chains favor the stagnation of pollutants. We found that the global correlations between the bin-averaged PM10 and AOD are R2 = 0.83 and R2 = 0.44 for MYD04_L2 and for MAIAC, respectively, suggesting a greater sensitivity of the high-resolution product to small-scale deviations. However, the introduction of Relative Humidity (RH) and Planetary Boundary Layer (PBL) depth corrections allowed for a significant improvement to the bin-averaged PM - AOD correlation, which led to a similar performance: R2 = 0.96 for MODIS and R2 = 0.95 for MAIAC. Furthermore, the introduction of the PBL information in the corrected AOD values was found to be crucial in order to capture the clear seasonal cycle shown by measured PM10 values. The study allowed us to define four seasonal linear correlations that estimate PM10 concentrations satisfactorily from the remotely sensed MAIAC AOD retrieval. Overall, the results show that the high resolution provided by MAIAC retrieval data is much more relevant than the 10 km MODIS data to characterize PM10 in this region of Italy which has a pretty limited geographical domain but a broad variety of land usages and consequent particulate concentrations.

Seasonal Monitoring and Estimation of Regional Aerosol Distribution over Po Valley, Northern Italy, Using a High-Resolution MAIAC Product

NASA Technical Reports Server (NTRS)

Arvani, Barbara; Pierce, R. Bradley; Lyapustin, Alexei I.; Wang, Yujie; Ghermandi, Grazia; Teggi, Sergio

2016-01-01

In this work, the new 1-km-resolved Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm is employed to characterize seasonal AOD-PM10 correlations over northern Italy. The accuracy of the new dataset is assessed versus the widely used Moderate Resolution Imaging Spectroradiometer (MODIS) Collection 5.1 Aerosol Optical Depth (AOD) data, retrieved at 0.55 microns with spatial resolution of 10 km (MYD04). We focused on evaluating the ability of these two products to characterize both temporal and spatial distributions of aerosols within urban and suburban areas. Ground PM10 measurements were obtained from 73 of the Italian Regional Agency for Environmental Protection (ARPA) monitoring stations, spread across northern Italy, for a three-year period from 2010 to 2012. The Po Valley area (northern Italy) was chosen as the study domain because of severe urban air pollution, resulting from the highest population and industrial manufacturing density in the country, being located in a valley where two surrounding mountain chains favor the stagnation of pollutants. We found that the global correlations between PM10 and AOD are R(sup 2) = 0.83 and R(sup 2) = 0.44 for MYD04_L2 and for MAIAC, respectively, suggesting for a greater sensitiveness of the high-resolution product to small-scale deviations. However, the introduction of Relative Humidity (RH) and Planetary Boundary Layer (PBL) depth corrections gave a significant improvement to the PM AOD correlation, which led to similar performance: R(sup 2) = 0.96 for MODIS and R(sup 2) = 0.95 for MAIAC. Furthermore, the introduction of the PBL information in the corrected AOD values was found to be crucial in order to capture the clear seasonal cycle shown by measured PM10 values. The study allowed us to define four seasonal linear correlations that estimate PM10 concentrations satisfactorily from the remotely sensed MAIAC AOD retrieval. Overall, the results show that the high resolution provided by MAIAC retrieval data is much more relevant than 10km MODIS data to characterize PM10 in this region of Italy which has a pretty limited geographical domain, but a broad variety of land usages and consequent particulate concentrations.

A revised inoceramid biozonation for the Upper Cretaceous based on high-resolution carbon isotope stratigraphy in northwestern Hokkaido, Japan

NASA Astrophysics Data System (ADS)

Hayakawa, Tatsuya; Hirano, Hiromichi

2013-06-01

Hayakawa, T., Hirano, H. 2013. A revised inoceramid biozonation for the Upper Cretaceous based on high-resolution carbon isotope stratigraphy in northwestern Hokkaido, Japan. Acta Geologica Polonica, 63 (2), 239-263. Warszawa. Biostratigraphic correlations of inoceramid bivalves between the North Pacific and Euramerican provinces have been difficult because the inoceramid biostratigraphy of the Japanese strata has been based on endemic species of the northwest Pacific. In this study, carbon stable isotope fluctuations of terrestrial organic matter are assembled for the Upper Cretaceous Yezo Group in the Haboro and Obira areas, Hokkaido, Japan, in order to revise the chronology of the inoceramid biozonation in Japan. The carbon isotope curves are correlated with those of marine carbonates in English and German sections with the aid of age-diagnostic taxa. According to the correlations of the carbon isotope curves, 11 isotope events are recognised in the sections studied. As a result of these correlations, the chronology of the inoceramid biozones of the Northwest Pacific has been considerably revised. The revised inoceramid biozones suggest that the timing of the origination and extinction of the inoceramids in the North Pacific biotic province is different from the stage/substage boundaries defined by inoceramids, as used in Europe and North America.

Sensitivity to grid resolution in the ability of a chemical transport model to simulate observed oxidant chemistry under high-isoprene conditions

NASA Astrophysics Data System (ADS)

Yu, Karen; Jacob, Daniel J.; Fisher, Jenny A.; Kim, Patrick S.; Marais, Eloise A.; Miller, Christopher C.; Travis, Katherine R.; Zhu, Lei; Yantosca, Robert M.; Sulprizio, Melissa P.; Cohen, Ron C.; Dibb, Jack E.; Fried, Alan; Mikoviny, Tomas; Ryerson, Thomas B.; Wennberg, Paul O.; Wisthaler, Armin

2016-04-01

Formation of ozone and organic aerosol in continental atmospheres depends on whether isoprene emitted by vegetation is oxidized by the high-NOx pathway (where peroxy radicals react with NO) or by low-NOx pathways (where peroxy radicals react by alternate channels, mostly with HO2). We used mixed layer observations from the SEAC4RS aircraft campaign over the Southeast US to test the ability of the GEOS-Chem chemical transport model at different grid resolutions (0.25° × 0.3125°, 2° × 2.5°, 4° × 5°) to simulate this chemistry under high-isoprene, variable-NOx conditions. Observations of isoprene and NOx over the Southeast US show a negative correlation, reflecting the spatial segregation of emissions; this negative correlation is captured in the model at 0.25° × 0.3125° resolution but not at coarser resolutions. As a result, less isoprene oxidation takes place by the high-NOx pathway in the model at 0.25° × 0.3125° resolution (54 %) than at coarser resolution (59 %). The cumulative probability distribution functions (CDFs) of NOx, isoprene, and ozone concentrations show little difference across model resolutions and good agreement with observations, while formaldehyde is overestimated at coarse resolution because excessive isoprene oxidation takes place by the high-NOx pathway with high formaldehyde yield. The good agreement of simulated and observed concentration variances implies that smaller-scale non-linearities (urban and power plant plumes) are not important on the regional scale. Correlations of simulated vs. observed concentrations do not improve with grid resolution because finer modes of variability are intrinsically more difficult to capture. Higher model resolution leads to decreased conversion of NOx to organic nitrates and increased conversion to nitric acid, with total reactive nitrogen oxides (NOy) changing little across model resolutions. Model concentrations in the lower free troposphere are also insensitive to grid resolution. The overall low sensitivity of modeled concentrations to grid resolution implies that coarse resolution is adequate when modeling continental boundary layer chemistry for global applications.

High-Resolution Subtropical Summer Precipitation Derived from Dynamical Downscaling of the NCEP-DOE Reanalysis: How Much Small-Scale Information Is Added by a Regional Model?

NASA Technical Reports Server (NTRS)

Lim, Young-Kwon; Stefanova, Lydia B.; Chan, Steven C.; Schubert, Siegfried D.; OBrien, James J.

2010-01-01

This study assesses the regional-scale summer precipitation produced by the dynamical downscaling of analyzed large-scale fields. The main goal of this study is to investigate how much the regional model adds smaller scale precipitation information that the large-scale fields do not resolve. The modeling region for this study covers the southeastern United States (Florida, Georgia, Alabama, South Carolina, and North Carolina) where the summer climate is subtropical in nature, with a heavy influence of regional-scale convection. The coarse resolution (2.5deg latitude/longitude) large-scale atmospheric variables from the National Center for Environmental Prediction (NCEP)/DOE reanalysis (R2) are downscaled using the NCEP Environmental Climate Prediction Center regional spectral model (RSM) to produce precipitation at 20 km resolution for 16 summer seasons (19902005). The RSM produces realistic details in the regional summer precipitation at 20 km resolution. Compared to R2, the RSM-produced monthly precipitation shows better agreement with observations. There is a reduced wet bias and a more realistic spatial pattern of the precipitation climatology compared with the interpolated R2 values. The root mean square errors of the monthly R2 precipitation are reduced over 93 (1,697) of all the grid points in the five states (1,821). The temporal correlation also improves over 92 (1,675) of all grid points such that the domain-averaged correlation increases from 0.38 (R2) to 0.55 (RSM). The RSM accurately reproduces the first two observed eigenmodes, compared with the R2 product for which the second mode is not properly reproduced. The spatial patterns for wet versus dry summer years are also successfully simulated in RSM. For shorter time scales, the RSM resolves heavy rainfall events and their frequency better than R2. Correlation and categorical classification (above/near/below average) for the monthly frequency of heavy precipitation days is also significantly improved by the RSM.

Near-surface tomography of southern California from noise cross-correlation H/V measurements

NASA Astrophysics Data System (ADS)

Muir, J. B.; Tsai, V. C.

2016-12-01

The development of noise cross-correlation techniques constitutes one of the major advances in observational seismology in the past 15 years. The first data derived from noise cross correlations were surface wave phase velocities, but as the technique matures many more observables of noise cross-correlations are being used in seismic studies. One such observable is the horizontal-to-vertical amplitude ratio (H/V) of noise cross-correlations. We interpret the H/V ratio of noise cross correlations in terms of Rayleigh wave ellipticity. We have inverted the H/V of Rayleigh waves observed in noise cross-correlation signals to develop a 3D tomogram of Southern California. This technique has recently been employed (e.g. Lin et al. 2014) on a continental scale, using data from the Transportable Array in the period range of 8-24s. The finer inter-station spacing of the SCSN allows retrieval of high signal-to-noise ratio Rayleigh waves at a period of as low as 2s, significantly improving the vertical resolution of the resulting tomography. In addition, horizontal resolution is naturally improved by increased station density. This study constitutes a useful addition to traditional phase-velocity based tomographic inversions due to the localized sensitivity of H/V measurements to the near surface of the measurement station site. The continuous data of 222 permanent broadband stations of the Southern California Seismic Network (SCSN) were used in production of noise cross-correlation waveforms, resulting in a spatially dense set of measurements for the Southern California region in the 2-15s period band. Tectonic sub-regions including the LA Basin and Salton Trough are clearly visible due to their high short-period H/V ratios, whilst the Transverse and Peninsular ranges exhibit low H/V at all periods.

CINCH (confocal incoherent correlation holography) super resolution fluorescence microscopy based upon FINCH (Fresnel incoherent correlation holography).

PubMed

Siegel, Nisan; Storrie, Brian; Bruce, Marc; Brooker, Gary

2015-02-07

FINCH holographic fluorescence microscopy creates high resolution super-resolved images with enhanced depth of focus. The simple addition of a real-time Nipkow disk confocal image scanner in a conjugate plane of this incoherent holographic system is shown to reduce the depth of focus, and the combination of both techniques provides a simple way to enhance the axial resolution of FINCH in a combined method called "CINCH". An important feature of the combined system allows for the simultaneous real-time image capture of widefield and holographic images or confocal and confocal holographic images for ready comparison of each method on the exact same field of view. Additional GPU based complex deconvolution processing of the images further enhances resolution.

Impacting the effect of fMRI noise through hardware and acquisition choices - Implications for controlling false positive rates.

PubMed

Wald, Lawrence L; Polimeni, Jonathan R

2017-07-01

We review the components of time-series noise in fMRI experiments and the effect of image acquisition parameters on the noise. In addition to helping determine the total amount of signal and noise (and thus temporal SNR), the acquisition parameters have been shown to be critical in determining the ratio of thermal to physiological induced noise components in the time series. Although limited attention has been given to this latter metric, we show that it determines the degree of spatial correlations seen in the time-series noise. The spatially correlations of the physiological noise component are well known, but recent studies have shown that they can lead to a higher than expected false-positive rate in cluster-wise inference based on parametric statistical methods used by many researchers. Based on understanding the effect of acquisition parameters on the noise mixture, we propose several acquisition strategies that might be helpful reducing this elevated false-positive rate, such as moving to high spatial resolution or using highly-accelerated acquisitions where thermal sources dominate. We suggest that the spatial noise correlations at the root of the inflated false-positive rate problem can be limited with these strategies, and the well-behaved spatial auto-correlation functions (ACFs) assumed by the conventional statistical methods are retained if the high resolution data is smoothed to conventional resolutions. Copyright © 2017 Elsevier Inc. All rights reserved.

Mapping carbon storage in urban trees with multi-source remote sensing data: relationships between biomass, land use, and demographics in Boston neighborhoods.

PubMed

Raciti, Steve M; Hutyra, Lucy R; Newell, Jared D

2014-12-01

High resolution maps of urban vegetation and biomass are powerful tools for policy-makers and community groups seeking to reduce rates of urban runoff, moderate urban heat island effects, and mitigate the effects of greenhouse gas emissions. We developed a very high resolution map of urban tree biomass, assessed the scale sensitivities in biomass estimation, compared our results with lower resolution estimates, and explored the demographic relationships in biomass distribution across the City of Boston. We integrated remote sensing data (including LiDAR-based tree height estimates) and field-based observations to map canopy cover and aboveground tree carbon storage at ~1m spatial scale. Mean tree canopy cover was estimated to be 25.5±1.5% and carbon storage was 355Gg (28.8MgCha(-1)) for the City of Boston. Tree biomass was highest in forest patches (110.7MgCha(-1)), but residential (32.8MgCha(-1)) and developed open (23.5MgCha(-1)) land uses also contained relatively high carbon stocks. In contrast with previous studies, we did not find significant correlations between tree biomass and the demographic characteristics of Boston neighborhoods, including income, education, race, or population density. The proportion of households that rent was negatively correlated with urban tree biomass (R(2)=0.26, p=0.04) and correlated with Priority Planting Index values (R(2)=0.55, p=0.001), potentially reflecting differences in land management among rented and owner-occupied residential properties. We compared our very high resolution biomass map to lower resolution biomass products from other sources and found that those products consistently underestimated biomass within urban areas. This underestimation became more severe as spatial resolution decreased. This research demonstrates that 1) urban areas contain considerable tree carbon stocks; 2) canopy cover and biomass may not be related to the demographic characteristics of Boston neighborhoods; and 3) that recent advances in high resolution remote sensing have the potential to improve the characterization and management of urban vegetation. Copyright © 2014 Elsevier B.V. All rights reserved.

Water-perfused manometry vs three-dimensional high-resolution manometry: a comparative study on a large patient population with anorectal disorders.

PubMed

Vitton, V; Ben Hadj Amor, W; Baumstarck, K; Grimaud, J-C; Bouvier, M

2013-12-01

Our aim was to compare for the first time measurements obtained with water-perfused catheter anorectal manometry and three-dimensional (3D) high-resolution manometry in patients with anorectal disorders. Consecutive patients referred to our centre for anorectal manometry (ARM) were recruited to undergo the two procedures successively. Conventional manometry was carried out using a water-perfused catheter (WPAM) and high-resolution manometry was achieved with a 3D probe (3DHRAM). For each procedure, parameters recorded included the following: anal canal length, resting pressure, squeeze pressure and rectal sensitivity. Two hundred and one patients were included in this study. The mean values for resting and squeeze pressures were correlated and found to be significantly higher when measured with 3DHRAM than with WPAM. However, the length of the anal canal was not significantly different when measured by the two techniques without correlation between the two mean values obtained. The presence of the rectoanal inhibitory reflex was systematically assessed by both WPAM and 3DHRAM and anismus was also systematically diagnosed by both WPAM and 3DHRAM. The pressure values obtained with 3DHRAM are correlated with those measured with conventional manometry but are systematically higher. 3DHRAM has the advantage of providing a pressure recording over the entire length and circumference of the anal canal, allowing a more useful physiological assessment of anorectal function. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.

Lung Ultrasonography in Patients With Idiopathic Pulmonary Fibrosis: Evaluation of a Simplified Protocol With High-Resolution Computed Tomographic Correlation.

PubMed

Vassalou, Evangelia E; Raissaki, Maria; Magkanas, Eleftherios; Antoniou, Katerina M; Karantanas, Apostolos H

2018-03-01

To compare a simplified ultrasonographic (US) protocol in 2 patient positions with the same-positioned comprehensive US assessments and high-resolution computed tomographic (CT) findings in patients with idiopathic pulmonary fibrosis. Twenty-five consecutive patients with idiopathic pulmonary fibrosis were prospectively enrolled and examined in 2 sessions. During session 1, patients were examined with a US protocol including 56 lung intercostal spaces in supine/sitting (supine/sitting comprehensive protocol) and lateral decubitus (decubitus comprehensive protocol) positions. During session 2, patients were evaluated with a 16-intercostal space US protocol in sitting (sitting simplified protocol) and left/right decubitus (decubitus simplified protocol) positions. The 16 intercostal spaces were chosen according to the prevalence of idiopathic pulmonary fibrosis-related changes on high-resolution CT. The sum of B-lines counted in each intercostal space formed the US scores for all 4 US protocols: supine/sitting and decubitus comprehensive US scores and sitting and decubitus simplified US scores. High-resolution CT-related Warrick scores (J Rheumatol 1991; 18:1520-1528) were compared to US scores. The duration of each protocol was recorded. A significant correlation was found between all US scores and Warrick scores and between simplified and corresponding comprehensive scores (P < .0001). Decubitus simplified US scores showed a slightly higher correlation with Warrick scores compared to sitting simplified US scores. Mean durations of decubitus and sitting simplified protocols were 4.76 and 6.20 minutes, respectively (P < .005). Simplified 16-intercostal space protocols correlated with comprehensive protocols and high-resolution CT findings in patients with idiopathic pulmonary fibrosis. The 16-intercostal space simplified protocol in the lateral decubitus position correlated better with high-resolution CT findings and was less time-consuming compared to the sitting position. © 2017 by the American Institute of Ultrasound in Medicine.

Four-Photon Imaging with Thermal Light

NASA Astrophysics Data System (ADS)

Wen, Feng; Xue, Xinxin; Zhang, Xun; Yuan, Chenzhi; Sun, Jia; Song, Jianping; Zhang, Yanpeng

2014-10-01

In a near-field four-photon correlation measurement, ghost imaging with classical incoherent light is investigated. By applying the Klyshko advanced-wave picture, we consider the properties of four-photon spatial correlation and find that the fourth-order spatial correlation function can be decomposed into multiple lower-order correlation functions. On the basis of the spatial correlation properties, a proof-of-principle four-photon ghost imaging is proposed, and the effect of each part in a fourth-order correlation function on imaging is also analyzed. In addition, the similarities and differences among ghost imaging by fourth-, second-, and third-order correlations are also discussed. It is shown that the contrast and visibility of fourth-order correlated imaging are improved significantly, while the resolution is unchanged. Such studies can be very useful in better understanding multi photon interference and multi-channel correlation imaging.

High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry.

PubMed

Choi, Won Seok; Kim, Tae Wan; Kim, Ja Hyun; Lee, Sang Hyuk; Hur, Woon Je; Choe, Young Gil; Lee, Sang Hyuk; Park, Jung Ho; Sohn, Chong Il

2013-10-01

Globus is a foreign body sense in the throat without dysphagia, odynophagia, esophageal motility disorders, or gastroesophageal reflux. The etiology is unclear. Previous studies suggested that increased upper esophageal sphincter pressure, gastroesophageal reflux and hypertonicity of esophageal body were possible etiologies. This study was to quantify the upper esophageal sphincter (UES) pressure, contractile front velocity (CFV), proximal contractile integral (PCI), distal contractile integral (DCI) and transition zone (TZ) in patient with globus gastroesophageal reflux disease (GERD) without globus, and normal controls to suggest the correlation of specific high-resolution manometry (HRM) findings and globus. Fifty-seven globus patients, 24 GERD patients and 7 normal controls were studied with HRM since 2009. We reviewed the reports, and selected 5 swallowing plots suitable for analysis in each report, analyzed each individual plot with ManoView. The 5 parameters from each plot in 57 globus patients were compared with that of 24 GERD patients and 7 normal controls. There was no significant difference in the UES pressure, CFV, PCI and DCI. TZ (using 30 mmHg isobaric contour) in globus showed significant difference compared with normal controls and GERD patients. The median values of TZ were 4.26 cm (interquartile range [IQR], 2.30-5.85) in globus patients, 5.91 cm (IQR, 3.97-7.62) in GERD patients and 2.26 cm (IQR, 1.22-2.92) in normal controls (P = 0.001). HRM analysis suggested that UES pressure, CFV, PCI and DCI were not associated with globus. Instead increased length of TZ may be correlated with globus. Further study comparing HRM results in globus patients within larger population needs to confirm their correlation.

High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry

PubMed Central

Choi, Won Seok; Kim, Tae Wan; Kim, Ja Hyun; Lee, Sang Hyuk; Hur, Woon Je; Choe, Young Gil; Lee, Sang Hyuk; Park, Jung Ho

2013-01-01

Background/Aims Globus is a foreign body sense in the throat without dysphagia, odynophagia, esophageal motility disorders, or gastroesophageal reflux. The etiology is unclear. Previous studies suggested that increased upper esophageal sphincter pressure, gastroesophageal reflux and hypertonicity of esophageal body were possible etiologies. This study was to quantify the upper esophageal sphincter (UES) pressure, contractile front velocity (CFV), proximal contractile integral (PCI), distal contractile integral (DCI) and transition zone (TZ) in patient with globus gastroesophageal reflux disease (GERD) without globus, and normal controls to suggest the correlation of specific high-resolution manometry (HRM) findings and globus. Methods Fifty-seven globus patients, 24 GERD patients and 7 normal controls were studied with HRM since 2009. We reviewed the reports, and selected 5 swallowing plots suitable for analysis in each report, analyzed each individual plot with ManoView. The 5 parameters from each plot in 57 globus patients were compared with that of 24 GERD patients and 7 normal controls. Results There was no significant difference in the UES pressure, CFV, PCI and DCI. TZ (using 30 mmHg isobaric contour) in globus showed significant difference compared with normal controls and GERD patients. The median values of TZ were 4.26 cm (interquartile range [IQR], 2.30-5.85) in globus patients, 5.91 cm (IQR, 3.97-7.62) in GERD patients and 2.26 cm (IQR, 1.22-2.92) in normal controls (P = 0.001). Conclusions HRM analysis suggested that UES pressure, CFV, PCI and DCI were not associated with globus. Instead increased length of TZ may be correlated with globus. Further study comparing HRM results in globus patients within larger population needs to confirm their correlation. PMID:24199007

What Makes a Defender? A Multilevel Study of Individual Correlates and Classroom Norms in Explaining Defending Behaviors

ERIC Educational Resources Information Center

Lucas-Molina, Beatriz; Giménez-Dasí, Marta; Fonseca-Pedrero, Eduardo; Pérez-Albéniz, Alicia

2018-01-01

This study examines the interplay between individual characteristics (social status, provictim attitudes, and family messages about conflict resolution) and classroom descriptive and injunctive norms (peer victimization behaviors and bullying-related beliefs, respectively) in explaining defending behavior. For this purpose, we used a…

Fluorescence lifetime imaging of induced pluripotent stem cells

NASA Astrophysics Data System (ADS)

Uchugonova, Aisada; Batista, Ana; König, Karsten

2014-02-01

The multiphoton FLIM tomograph MPTflex with its flexible scan head, articulated arm, and the tunable femtosecond laser source was employed to study cell monolayers and 3D cell clusters. FLIM was performed with 250 ps temporal resolution and submicron special resolution using time-correlated single photon counting. The autofluorescence based on NAD(P)H and flavins/flavoproteins has been measured in mouse embryonic fibroblasts, induced pluripotent stem cells (iPS cells) originated from mouse embryonic fibroblasts and non-proliferative mouse embryonic fibroblasts.

Correlation between histological and ultrasonographic findings of soft tissue tumors: To verify the possibility of cell-like resolution in ultrasonography.

PubMed

Wu, Ching-Lan; Lai, Yi-Chen; Wang, Hsin-Kai; Chen, Paul Chih-Hsueh; Chiou, Hong-Jen

2017-11-01

The purpose of this study is to test the possibility of obtained cell-like resolution in soft tissue tumors on the basis of ultrasound echotexture. This is a prospective study consisting of 57 patients (29 females and 28 males, age range: 9-83 years, average age: 44.5 years) with palpable soft tissue mass, referred from the Departments of Orthopedics and Oncology for ultrasound (US)-guided biopsy. The study was approved by the institutional review board (IRB) of our hospital. Ultrasonographic images were recorded by still imaging in the biopsy tract in each biopsy session. Equipment included curvilinear and linear array probes. After biopsy, a radiologist and a pathologist correlated the US image and the observations regarding the histology of the tissue specimen in low-power (40 × magnification) and high-power (100-400 × magnification) fields. The histologic results included 22 benign and 35 malignant lesions. The echotexture of the soft tissue tumors correlated well with the cellular distribution and arrangement: the greater the number of cells and the more regular their arrangement as seen histologically, the greater is the hypoechogenicity on the ultrasound. The echogenicity of the soft tissue tumor also correlated well with the presence of fat cells, hemorrhage, cartilage, and osteoid tissue, all of which cause an increase in echogenicity. This study showed that the echotexture of soft tissue tumors can predict some details of cellular histology. Copyright © 2017. Published by Elsevier Taiwan LLC.

A Survery of the Correlation between Filament Chirality and Sigmoid Handedness

NASA Astrophysics Data System (ADS)

V, A.; Hazra, S.; Martin, S. F.; Martens, P. C.

2017-12-01

Sigmoid regions on the Sun are often the regions that cause Coronal Mass Ejections (CMEs). Large CMEs most often have filaments that erupt with them. This study focuses on the statistical relevance of the shape of the sigmoid and the chirality of the filament residing in these sigmoids. The study further extends to the relation between the directionality of filaments and the Earth-directed CMEs. Sigmoid data from Savcheva et al. (2014) between 2007 and 2012 and a compilation of data using the HEK Sigmoid Sniffer (Martens et al. 2012) along with Hinode XRT Soft X-ray images were used for analyzing data between 2013 and 2017. Hence this dataset consists of almost one solar cycle of data. A similar study done previously by Martens et al. (2013) analysed data for a solar cycle using an Advanced Automated Filament Detection & Characterization Code (Bernasconi, Rust & Hakim 2005). Considering that automated chirality detection is not foolproof, we present this study which uses manual determination of chirality for accuracy using high resolution chromospheric images. Mainly full disk images of soft X-ray obtained from Hinode XRT (X-Ray Telescope) have been used to find and ensure the S or Z shape of sigmoids. H-alpha images obtained from BBSO and Kanzelhohe Solar Observatory (KSO) are used in determining the chirality of filaments. The resolutions of BBSO and KSO data are 1k and 4k respectively. A comparison of the analysis of the chirality of filaments using both data will be presented. Although KSO gives a 4k resolution, it is still difficult to determine the chirality of small filaments. For this reason, high resolution images of H-alpha chromospheric filaments obtained from Helio Research and Solar Observing Optical Network (SOON) have been used for further analysis of chirality of those filaments that were undeterminable using the BBSO or KSO full disk images. The results of the comparison using the different resolutions are shown. The results of the correlation between sigmoid shape and filament chirality are also shown. Further, these results are used in determining the correlation with Earth directed CMEs and those that cause geo-magnetic storms. Savacheva, A. S., McKillop, S. C., McCauley, P. I., et al., 2014, 289Bernasconi, P. N., Rust, D. M., & Hakim, D., 2005, Sol. Phys., 228, 97 Martens, P., Yeates, A., & Pillai, K., 2013, IAU, 3000

A novel high-resolution chaotic lidar with optical injection to chaotic laser diode

NASA Astrophysics Data System (ADS)

Wang, Yun-cai; Wang, An-bang

2008-03-01

A novel chaotic lidar with high resolution is proposed and studied theoretically. In chaotic lidar system, the chaotic laser emitted from chaotic laser diode is split into two beams: the probe and the reference light. The ranging is achieved by correlating the reference waveform with the delayed probe waveform backscattered from the target. In chaotic lidar systems presented previously, the chaotic signal source is laser diode with optical feedback or with optical injection by another one. The ranging resolution is limited by the bandwidth of chaotic laser which determined by the configuration of chaotic signal source. We proposed a novel chaotic lidar which ranging resolution is enhanced significantly by external optical injected chaotic laser diode. With the bandwidth-enhanced chaotic laser, the range resolution of the chaotic lidar system with optical injection is roughly two times compared with that of without optical injection. The resolution increases with injection strength increasing in a certain frequency detuning range.

Evaluation of a 3D local multiresolution algorithm for the correction of partial volume effects in positron emission tomography

PubMed Central

Le Pogam, Adrien; Hatt, Mathieu; Descourt, Patrice; Boussion, Nicolas; Tsoumpas, Charalampos; Turkheimer, Federico E.; Prunier-Aesch, Caroline; Baulieu, Jean-Louis; Guilloteau, Denis; Visvikis, Dimitris

2011-01-01

Purpose Partial volume effects (PVE) are consequences of the limited spatial resolution in emission tomography leading to under-estimation of uptake in tissues of size similar to the point spread function (PSF) of the scanner as well as activity spillover between adjacent structures. Among PVE correction methodologies, a voxel-wise mutual multi-resolution analysis (MMA) was recently introduced. MMA is based on the extraction and transformation of high resolution details from an anatomical image (MR/CT) and their subsequent incorporation into a low resolution PET image using wavelet decompositions. Although this method allows creating PVE corrected images, it is based on a 2D global correlation model which may introduce artefacts in regions where no significant correlation exists between anatomical and functional details. Methods A new model was designed to overcome these two issues (2D only and global correlation) using a 3D wavelet decomposition process combined with a local analysis. The algorithm was evaluated on synthetic, simulated and patient images, and its performance was compared to the original approach as well as the geometric transfer matrix (GTM) method. Results Quantitative performance was similar to the 2D global model and GTM in correlated cases. In cases where mismatches between anatomical and functional information were present the new model outperformed the 2D global approach, avoiding artefacts and significantly improving quality of the corrected images and their quantitative accuracy. Conclusions A new 3D local model was proposed for a voxel-wise PVE correction based on the original mutual multi-resolution analysis approach. Its evaluation demonstrated an improved and more robust qualitative and quantitative accuracy compared to the original MMA methodology, particularly in the absence of full correlation between anatomical and functional information. PMID:21978037

Integrative Spatial Data Analytics for Public Health Studies of New York State

PubMed Central

Chen, Xin; Wang, Fusheng

2016-01-01

Increased accessibility of health data made available by the government provides unique opportunity for spatial analytics with much higher resolution to discover patterns of diseases, and their correlation with spatial impact indicators. This paper demonstrated our vision of integrative spatial analytics for public health by linking the New York Cancer Mapping Dataset with datasets containing potential spatial impact indicators. We performed spatial based discovery of disease patterns and variations across New York State, and identify potential correlations between diseases and demographic, socio-economic and environmental indicators. Our methods were validated by three correlation studies: the correlation between stomach cancer and Asian race, the correlation between breast cancer and high education population, and the correlation between lung cancer and air toxics. Our work will allow public health researchers, government officials or other practitioners to adequately identify, analyze, and monitor health problems at the community or neighborhood level for New York State. PMID:28269834

A High Resolution Microprobe Study of EETA79001 Lithology C

NASA Technical Reports Server (NTRS)

Schrader, Christian M.; Cohen, B. A.; Donovan, J. J.; Vicenzi, E. P.

2010-01-01

Antarctic meteorite EETA79001 has received substantial attention for possibly containing a component of Martian soil in its impact glass (Lithology C) [1]. The composition of Martian soil can illuminate near-surface processes such as impact gardening [2] and hydrothermal and volcanic activity [3,4]. Impact melts in meteorites represent our most direct samples of Martian regolith. We present the initial findings from a high-resolution electron microprobe study of Lithology C from Martian meteorite EETA79001. As this study develops we aim to extract details of a potential soil composition and to examine Martian surface processes using elemental ratios and correlations.

Discrimination of Fritillary according to geographical origin with Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy.

PubMed

Hua, Rui; Sun, Su-Qin; Zhou, Qun; Noda, Isao; Wang, Bao-Qin

2003-09-19

Fritillaria is a traditional Chinese herbal medicine for eliminating phlegm and relieving a cough with a long history in China and some other Asian countries. The objective of this study is to develop a nondestructive and accurate method to discriminate Fritillaria of different geographical origins, which is a troublesome work by existing analytical methods. We conducted a systematic study on five kinds of Fritillaria by Fourier transform infrared spectroscopy, second derivative infrared spectroscopy, and two-dimensional (2D) correlation infrared spectroscopy under thermal perturbation. Because Fritillaria consist of a large amount of starch, the conventional IR spectra of different Fritillaria only have very limited spectral feature differences. Based on these differences, we can separate different Fritillaria to a limited extent, but this method was deemed not very practical. The second derivative IR spectra of Fritillaria could enhance spectrum resolution, amplify the differences between the IR spectra of different Fritillaria, and provide some dissimilarity in their starch content, when compared with the spectrum of pure starch. Finally, we applied thermal perturbation to Fritillaria and analyzed the resulting spectra by the 2D correlation method to distinguish different Fritillaria easily and clearly. The distinction of very similar Fritillaria was possible because the spectral resolution was greatly enhanced by the 2D correlation spectroscopy. In addition, with the dynamic information of molecular structure provided by 2D correlation IR spectra, we studied the differences in the stability of active components of Fritillaria. The differences embodied mainly on the intensity ratio of the auto-peak at 985 cm(-1) and other auto-peaks. The 2D correlation IR spectroscopy (2D IR) of Fritillaria can be a new and powerful method to discriminate Fritillaria.

Integrating palaeoenvironmental and climate cyclicities - Optimizing the stratigraphic framework in the non-marine Lower Cretaceous

NASA Astrophysics Data System (ADS)

Sames, Benjamin

2015-04-01

Studies on changing paleoenvironments and climate cycles in non-marine archives of the Cretaceous greenhouse earth are hitherto rare, primarily a result of the lack of high-resolution stratigraphy and correlations to the marine record. On the other hand, recent refinements of the geological time scale have made major advances for the Cretaceous to yield a resolution comparable to that of younger Earth history. In the Cretaceous marine record is now possible to correlate and date short-term sea-level records and their possible relation to climate and/or tectonic events with appropriate resolution. Correlation in the non-marine realm ('continental' aquatic) has long been fraught with considerable problems and limitations, especially on supraregional (i.e., inter-basinal) to global scales, thus often hampering serious attempts at dating and chronological linking of events documented by the respective deposits - let alone appropriate correlation to marine successions. A new interdisciplinary project and multi-proxy study funded by the Austrian Science Fund (FWF) uses the Lower Cretaceous European record (English Wealden) as a test site for the integration of ostracod biostratigraphy and assemblage changes, and cyclostratigraphy (orbitally/climate driven cycles). Ostracods (microcrustaceans with a calcified shell) are the most useful biostratigraphical and palaeoenvironmental tool in Lower Cretaceous non-marine sequences. During the past two decades, research progress in late Mesozoic non-marine ostracods led to their extended applicability, whereas their wide dispersal ability has become a key conside-ration in their supraregional (inter-basinal to global) biostratigraphical utility. The integrative methodology applied in this project, targets the correlation of the ostracod faunal composition change with the variation of geochemical and sedimentological parameters through time and inferences on controlling (palaeoenvironmental) factors and their regulating mechanisms ('climate changes', orbital cycles?). The approach is multiple: 1) Biostratigraphy in the supraregional to global context, 2) cyclostratigraphy using ostracods, lithologic parameters and sediment geochemistry, 3) stable isotope geochemistry, and 4) magnetostratigraphy for chronological control. The methods used, evaluated and optimized within the scope of this project can then be efficiently applied on larger scopes and to larger datasets towards a better linking of marine and non-marine Cretaceous successions, enhancement of resolution in the considerable (particularly Lower) Cretaceous non-marine record, and integration of these data into the Cretaceous timescale.

In-situ Isotopic Analysis at Nanoscale using Parallel Ion Electron Spectrometry: A Powerful New Paradigm for Correlative Microscopy

NASA Astrophysics Data System (ADS)

Yedra, Lluís; Eswara, Santhana; Dowsett, David; Wirtz, Tom

2016-06-01

Isotopic analysis is of paramount importance across the entire gamut of scientific research. To advance the frontiers of knowledge, a technique for nanoscale isotopic analysis is indispensable. Secondary Ion Mass Spectrometry (SIMS) is a well-established technique for analyzing isotopes, but its spatial-resolution is fundamentally limited. Transmission Electron Microscopy (TEM) is a well-known method for high-resolution imaging down to the atomic scale. However, isotopic analysis in TEM is not possible. Here, we introduce a powerful new paradigm for in-situ correlative microscopy called the Parallel Ion Electron Spectrometry by synergizing SIMS with TEM. We demonstrate this technique by distinguishing lithium carbonate nanoparticles according to the isotopic label of lithium, viz. 6Li and 7Li and imaging them at high-resolution by TEM, adding a new dimension to correlative microscopy.

TH-EF-BRA-11: Feasibility of Super-Resolution Time-Resolved 4DMRI for Multi-Breath Volumetric Motion Simulation in Radiotherapy Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, G; Zakian, K; Deasy, J

Purpose: To develop a novel super-resolution time-resolved 4DMRI technique to evaluate multi-breath, irregular and complex organ motion without respiratory surrogate for radiotherapy planning. Methods: The super-resolution time-resolved (TR) 4DMRI approach combines a series of low-resolution 3D cine MRI images acquired during free breathing (FB) with a high-resolution breath-hold (BH) 3DMRI via deformable image registration (DIR). Five volunteers participated in the study under an IRB-approved protocol. The 3D cine images with voxel size of 5×5×5 mm{sup 3} at two volumes per second (2Hz) were acquired coronally using a T1 fast field echo sequence, half-scan (0.8) acceleration, and SENSE (3) parallel imaging.more » Phase-encoding was set in the lateral direction to minimize motion artifacts. The BH image with voxel size of 2×2×2 mm{sup 3} was acquired using the same sequence within 10 seconds. A demons-based DIR program was employed to produce super-resolution 2Hz 4DMRI. Registration quality was visually assessed using difference images between TR 4DMRI and 3D cine and quantitatively assessed using average voxel correlation. The fidelity of the 3D cine images was assessed using a gel phantom and a 1D motion platform by comparing mobile and static images. Results: Owing to voxel intensity similarity using the same MRI scanning sequence, accurate DIR between FB and BH images is achieved. The voxel correlations between 3D cine and TR 4DMRI are greater than 0.92 in all cases and the difference images illustrate minimal residual error with little systematic patterns. The 3D cine images of the mobile gel phantom preserve object geometry with minimal scanning artifacts. Conclusion: The super-resolution time-resolved 4DMRI technique has been achieved via DIR, providing a potential solution for multi-breath motion assessment. Accurate DIR mapping has been achieved to map high-resolution BH images to low-resolution FB images, producing 2Hz volumetric high-resolution 4DMRI. Further validation and improvement are still required prior to clinical applications. This study is in part supported by the NIH (U54CA137788/U54CA132378).« less

FitEM2EM—Tools for Low Resolution Study of Macromolecular Assembly and Dynamics

PubMed Central

Frankenstein, Ziv; Sperling, Joseph; Sperling, Ruth; Eisenstein, Miriam

2008-01-01

Studies of the structure and dynamics of macromolecular assemblies often involve comparison of low resolution models obtained using different techniques such as electron microscopy or atomic force microscopy. We present new computational tools for comparing (matching) and docking of low resolution structures, based on shape complementarity. The matched or docked objects are represented by three dimensional grids where the value of each grid point depends on its position with regard to the interior, surface or exterior of the object. The grids are correlated using fast Fourier transformations producing either matches of related objects or docking models depending on the details of the grid representations. The procedures incorporate thickening and smoothing of the surfaces of the objects which effectively compensates for differences in the resolution of the matched/docked objects, circumventing the need for resolution modification. The presented matching tool FitEM2EMin successfully fitted electron microscopy structures obtained at different resolutions, different conformers of the same structure and partial structures, ranking correct matches at the top in every case. The differences between the grid representations of the matched objects can be used to study conformation differences or to characterize the size and shape of substructures. The presented low-to-low docking tool FitEM2EMout ranked the expected models at the top. PMID:18974836

Tri-stereo Pleiades images-derived digital surface models for tectonic geomorphology studies

NASA Astrophysics Data System (ADS)

Ferry, Matthieu; Le Roux-Mallouf, Romain; Ritz, Jean-François; Berthet, Théo; Peyret, Michel; Vernant, Philippe; Maréchal, Anaïs; Cattin, Rodolphe; Mazzotti, Stéphane; Poujol, Antoine

2014-05-01

Very high resolution digital elevation models are a key component of modern quantitative geomorphology. In parallel to high-precision but time-consuming kinematic GPS and/or total station surveys and dense coverage but expensive LiDAR campaigns, we explore the usability of affordable, flexible, wide coverage digital surface models (DSMs) derived from Pleiades tri-stereo optical images. We present two different approaches to extract DSM from a triplet of images. The first relies on the photogrammetric extraction of 3 DSMs from the 3 possible stereo couples and subsequent merge based on the best correlation score. The second takes advantage of simultaneous correlation over the 3 images to derive a point cloud. We further extract DSM from panchromatic 0.5 m resolution images and multispectral 2 m resolution images to test for correlation and noise and determine optimal correlation window size and achievable resolution. Georeferencing is also assessed by comparing raw coordinates derived from Pleiades Rational Polynomial Coefficients to ground control points. Primary images appear to be referenced within ~15 m over flat areas where parallax is minimal while derived DSMs and associated orthorectified images show a much improved referencing within ~5 m of GCPs. In order to assess the adequacy of Pleiades DSMs for tectonic geomorphology, we present examples from case studies along the Trougout normal fault (Morocco), the Hovd strike-slip fault (Mongolia), the Denali strike-slip fault (USA and Canada) and the Main Frontal Thrust (Bhutan). In addition to proposing a variety of tectonic contexts, these examples cover a wide range of climatic conditions (semi-arid, arctic and tropical), vegetation covers (bare earth, sparse Mediterranean, homogeneous arctic pine, varied tropical forest), lithological natures and related erosion rates. The capacity of derived DSMs is demonstrated to characterize geomorphic markers of active deformation such as marine and alluvial terraces, stream gullies, alluvial fans and fluvio-glacial deposits in terms of vertical (from DSMs) and horizontal (from orthorectified optical images) offsets. Values extracted from Pleiades DSMs compare well to field measurements in terms of relief and slope, which suggests effort and resources necessary for field topography could be significantly reduced, especially in poorly accessible areas.

VALIDATION OF A CLINICAL ASSESSMENT OF SPECTRAL RIPPLE RESOLUTION FOR COCHLEAR-IMPLANT USERS

PubMed Central

Drennan, Ward. R.; Anderson, Elizabeth S.; Won, Jong Ho; Rubinstein, Jay T.

2013-01-01

Objectives Non-speech psychophysical tests of spectral resolution, such as the spectral-ripple discrimination task, have been shown to correlate with speech recognition performance in cochlear implant (CI) users (Henry et al., 2005; Won et al. 2007, 2011; Drennan et al. 2008; Anderson et al. 2011). However, these tests are best suited for use in the research laboratory setting and are impractical for clinical use. A test of spectral resolution that is quicker and could more easily be implemented in the clinical setting has been developed. The objectives of this study were 1) To determine if this new clinical ripple test would yield individual results equivalent to the longer, adaptive version of the ripple discrimination test; 2) To evaluate test-retest reliability for the clinical ripple measure; and 3) To examine the relationship between clinical ripple performance and monosyllabic word recognition in quiet for a group of CI listeners. Design Twenty-eight CI recipients participated in the study. Each subject was tested on both the adaptive and the clinical versions of spectral ripple discrimination, as well as CNC word recognition in quiet. The adaptive version of spectral ripple employed a 2-up, 1-down procedure for determining spectral ripple discrimination threshold. The clinical ripple test used a method of constant stimuli, with trials for each of 12 fixed ripple densities occurring six times in random order. Results from the clinical ripple test (proportion correct) were then compared to ripple discrimination thresholds (in ripples per octave) from the adaptive test. Results The clinical ripple test showed strong concurrent validity, evidenced by a good correlation between clinical ripple and adaptive ripple results (r=0.79), as well as a correlation with word recognition (r = 0.7). Excellent test-retest reliability was also demonstrated with a high test-retest correlation (r = 0.9). Conclusions The clinical ripple test is a reliable non-linguistic measure of spectral resolution, optimized for use with cochlear implant users in a clinical setting. The test might be useful as a diagnostic tool or as a possible surrogate outcome measure for evaluating treatment effects in hearing. PMID:24552679

CINCH (confocal incoherent correlation holography) super resolution fluorescence microscopy based upon FINCH (Fresnel incoherent correlation holography)

PubMed Central

Siegel, Nisan; Storrie, Brian; Bruce, Marc

2016-01-01

FINCH holographic fluorescence microscopy creates high resolution super-resolved images with enhanced depth of focus. The simple addition of a real-time Nipkow disk confocal image scanner in a conjugate plane of this incoherent holographic system is shown to reduce the depth of focus, and the combination of both techniques provides a simple way to enhance the axial resolution of FINCH in a combined method called “CINCH”. An important feature of the combined system allows for the simultaneous real-time image capture of widefield and holographic images or confocal and confocal holographic images for ready comparison of each method on the exact same field of view. Additional GPU based complex deconvolution processing of the images further enhances resolution. PMID:26839443

Velocity landscape correlation resolves multiple flowing protein populations from fluorescence image time series.

PubMed

Pandžić, Elvis; Abu-Arish, Asmahan; Whan, Renee M; Hanrahan, John W; Wiseman, Paul W

2018-02-16

Molecular, vesicular and organellar flows are of fundamental importance for the delivery of nutrients and essential components used in cellular functions such as motility and division. With recent advances in fluorescence/super-resolution microscopy modalities we can resolve the movements of these objects at higher spatio-temporal resolutions and with better sensitivity. Previously, spatio-temporal image correlation spectroscopy has been applied to map molecular flows by correlation analysis of fluorescence fluctuations in image series. However, an underlying assumption of this approach is that the sampled time windows contain one dominant flowing component. Although this was true for most of the cases analyzed earlier, in some situations two or more different flowing populations can be present in the same spatio-temporal window. We introduce an approach, termed velocity landscape correlation (VLC), which detects and extracts multiple flow components present in a sampled image region via an extension of the correlation analysis of fluorescence intensity fluctuations. First we demonstrate theoretically how this approach works, test the performance of the method with a range of computer simulated image series with varying flow dynamics. Finally we apply VLC to study variable fluxing of STIM1 proteins on microtubules connected to the plasma membrane of Cystic Fibrosis Bronchial Epithelial (CFBE) cells. Copyright © 2018 Elsevier Inc. All rights reserved.

Using synchrotron radiation angiography with a highly sensitive detector to identify impaired peripheral perfusion in rat pulmonary emphysema

PubMed Central

Ito, Hiromichi; Matsushita, Shonosuke; Hyodo, Kazuyuki; Sato, Yukio; Sakakibara, Yuzuru

2013-01-01

Owing to limitations in spatial resolution and sensitivity, it is difficult for conventional angiography to detect minute changes of perfusion in diffuse lung diseases, including pulmonary emphysema (PE). However, a high-gain avalanche rushing amorphous photoconductor (HARP) detector can give high sensitivity to synchrotron radiation (SR) angiography. SR angiography with a HARP detector provides high spatial resolution and sensitivity in addition to time resolution owing to its angiographic nature. The purpose of this study was to investigate whether this SR angiography with a HARP detector could evaluate altered microcirculation in PE. Two groups of rats were used: group PE and group C (control). Transvenous SR angiography with a HARP detector was performed and histopathological findings were compared. Peak density of contrast material in peripheral lung was lower in group PE than group C (p < 0.01). The slope of the linear regression line in scattering diagrams was also lower in group PE than C (p < 0.05). The correlation between the slope and extent of PE in histopathology showed significant negative correlation (p < 0.05, r = 0.61). SR angiography with a HARP detector made it possible to identify impaired microcirculation in PE by means of its high spatial resolution and sensitivity. PMID:23412496

Land surface sensitivity of monsoon depressions formed over Bay of Bengal using improved high-resolution land state

NASA Astrophysics Data System (ADS)

Rajesh, P. V.; Pattnaik, S.; Mohanty, U. C.; Rai, D.; Baisya, H.; Pandey, P. C.

2017-12-01

Monsoon depressions (MDs) constitute a large fraction of the total rainfall during the Indian summer monsoon season. In this study, the impact of high-resolution land state is addressed by assessing the evolution of inland moving depressions formed over the Bay of Bengal using a mesoscale modeling system. Improved land state is generated using High Resolution Land Data Assimilation System employing Noah-MP land-surface model. Verification of soil moisture using Soil Moisture and Ocean Salinity (SMOS) and soil temperature using tower observations demonstrate promising results. Incorporating high-resolution land state yielded least root mean squared errors with higher correlation coefficient in the surface and mid tropospheric parameters. Rainfall forecasts reveal that simulations are spatially and quantitatively in accordance with observations and provide better skill scores. The improved land surface characteristics have brought about the realistic evolution of surface, mid-tropospheric parameters, vorticity and moist static energy that facilitates the accurate MDs dynamics in the model. Composite moisture budget analysis reveals that the surface evaporation is negligible compared to moisture flux convergence of water vapor, which supplies moisture into the MDs over land. The temporal relationship between rainfall and moisture convergence show high correlation, suggesting a realistic representation of land state help restructure the moisture inflow into the system through rainfall-moisture convergence feedback.

Monitoring of PBDEs concentration in umbilical cord blood and breast milk from Korean population and estimating the effects of various parameters on accumulation in humans.

PubMed

Kim, Un-Jung; Lee, In-Seok; Kim, Hyung Sik; Oh, Jeong-Eun

2011-10-01

In this study, we investigated concentration, congener distribution pattern, and effects of potential environmental factors that affect PBDE accumulation. We also estimated correlation between PBDE concentration and health status or thyroid function by analyzing 90 cord blood and 21 breast milk samples obtained from Korean population. Seven from tri- to hepta-BDEs were analyzed by solid phase extraction-high-resolution gas chromatography/high-resolution mass spectrometry (SPE-HRGC/HRMS). The total concentration of 7 PBDEs in cord blood was 2.786-94.64 ng g(-1) lipid and that in breast milk was 1.076-8.664 ng g(-1) lipid. Tetra-BDE (#47) was the predominant type of PBDE and was present at concentrations of over 40% in both sample types. A weak correlation was observed between the concentration of BDE28 and 153 and thyroid hormone concentration only in the breast milk samples. In children, a weak negative correlation was observed between free thyroxine (FT4) concentration and BDE28 concentration (0.302, p<0.05), while in mothers, a weak positive correlation was observed between thyroid hormone concentration and BDE153 concentration (0.403, p<0.05). No significant correlations between PBDE concentration and work and residential environments were found in this study, but a weak correlation between BDE concentration in cord blood and potential PBDE sources was confirmed by investigating the frequency of oil paint usage (0.510, p<0.001). A weak correlation was also found between PBDE concentration in breast milk during pregnancy and dietary habits such as green tea drinking (0.541, p=0.025) and Trichiuridae intake (0.565, p=0.015). Copyright © 2011 Elsevier Ltd. All rights reserved.

Nanoscale simultaneous chemical and mechanical imaging via peak force infrared microscopy

PubMed Central

Wang, Le; Wang, Haomin; Wagner, Martin; Yan, Yong; Jakob, Devon S.; Xu, Xiaoji G.

2017-01-01

Nondestructive chemical and mechanical measurements of materials with ~10-nm spatial resolution together with topography provide rich information on the compositions and organizations of heterogeneous materials and nanoscale objects. However, multimodal nanoscale correlations are difficult to achieve because of the limitation on spatial resolution of optical microscopy and constraints from instrumental complexities. We report a novel noninvasive spectroscopic scanning probe microscopy method—peak force infrared (PFIR) microscopy—that allows chemical imaging, collection of broadband infrared spectra, and mechanical mapping at a spatial resolution of 10 nm. In our technique, chemical absorption information is directly encoded in the withdraw curve of the peak force tapping cycle after illumination with synchronized infrared laser pulses in a simple apparatus. Nanoscale phase separation in block copolymers and inhomogeneity in CH3NH3PbBr3 perovskite crystals are studied with correlative infrared/mechanical nanoimaging. Furthermore, we show that the PFIR method is sensitive to the presence of surface phonon polaritons in boron nitride nanotubes. PFIR microscopy will provide a powerful analytical tool for explorations at the nanoscale across wide disciplines. PMID:28691096

A novel fast phase correlation algorithm for peak wavelength detection of Fiber Bragg Grating sensors.

PubMed

Lamberti, A; Vanlanduit, S; De Pauw, B; Berghmans, F

2014-03-24

Fiber Bragg Gratings (FBGs) can be used as sensors for strain, temperature and pressure measurements. For this purpose, the ability to determine the Bragg peak wavelength with adequate wavelength resolution and accuracy is essential. However, conventional peak detection techniques, such as the maximum detection algorithm, can yield inaccurate and imprecise results, especially when the Signal to Noise Ratio (SNR) and the wavelength resolution are poor. Other techniques, such as the cross-correlation demodulation algorithm are more precise and accurate but require a considerable higher computational effort. To overcome these problems, we developed a novel fast phase correlation (FPC) peak detection algorithm, which computes the wavelength shift in the reflected spectrum of a FBG sensor. This paper analyzes the performance of the FPC algorithm for different values of the SNR and wavelength resolution. Using simulations and experiments, we compared the FPC with the maximum detection and cross-correlation algorithms. The FPC method demonstrated a detection precision and accuracy comparable with those of cross-correlation demodulation and considerably higher than those obtained with the maximum detection technique. Additionally, FPC showed to be about 50 times faster than the cross-correlation. It is therefore a promising tool for future implementation in real-time systems or in embedded hardware intended for FBG sensor interrogation.

Contributed review: Review of integrated correlative light and electron microscopy.

PubMed

Timmermans, F J; Otto, C

2015-01-01

New developments in the field of microscopy enable to acquire increasing amounts of information from large sample areas and at an increased resolution. Depending on the nature of the technique, the information may reveal morphological, structural, chemical, and still other sample characteristics. In research fields, such as cell biology and materials science, there is an increasing demand to correlate these individual levels of information and in this way to obtain a better understanding of sample preparation and specific sample properties. To address this need, integrated systems were developed that combine nanometer resolution electron microscopes with optical microscopes, which produce chemically or label specific information through spectroscopy. The complementary information from electron microscopy and light microscopy presents an opportunity to investigate a broad range of sample properties in a correlated fashion. An important part of correlating the differences in information lies in bridging the different resolution and image contrast features. The trend to analyse samples using multiple correlated microscopes has resulted in a new research field. Current research is focused, for instance, on (a) the investigation of samples with nanometer scale distribution of inorganic and organic materials, (b) live cell analysis combined with electron microscopy, and (c) in situ spectroscopic and electron microscopy analysis of catalytic materials, but more areas will benefit from integrated correlative microscopy.

Geostatistical Analysis of Surface Temperature and In-Situ Soil Moisture Using LST Time-Series from Modis

NASA Astrophysics Data System (ADS)

Sohrabinia, M.; Rack, W.; Zawar-Reza, P.

2012-07-01

The objective of this analysis is to provide a quantitative estimate of the fluctuations of land surface temperature (LST) with varying near surface soil moisture (SM) on different land-cover (LC) types. The study area is located in the Canterbury Plains in the South Island of New Zealand. Time series of LST from the MODerate resolution Imaging Spectro-radiometer (MODIS) have been analysed statistically to study the relationship between the surface skin temperature and near-surface SM. In-situ measurements of the skin temperature and surface SM with a quasi-experimental design over multiple LC types are used for validation. Correlations between MODIS LST and in-situ SM, as well as in-situ surface temperature and SM are calculated. The in-situ measurements and MODIS data are collected from various LC types. Pearson's r correlation coefficient and linear regression are used to fit the MODIS LST and surface skin temperature with near-surface SM. There was no significant correlation between time-series of MODIS LST and near-surface SM from the initial analysis, however, careful analysis of the data showed significant correlation between the two parameters. Night-time series of the in-situ surface temperature and SM from a 12 hour period over Irrigated-Crop, Mixed-Grass, Forest, Barren and Open- Grass showed inverse correlations of -0.47, -0.68, -0.74, -0.88 and -0.93, respectively. These results indicated that the relationship between near-surface SM and LST in short-terms (12 to 24 hours) is strong, however, remotely sensed LST with higher temporal resolution is required to establish this relationship in such time-scales. This method can be used to study near-surface SM using more frequent LST observations from a geostationary satellite over the study area.

PLACD-7T Study: Atherosclerotic Carotid Plaque Components Correlated with Cerebral Damage at 7 Tesla Magnetic Resonance Imaging

PubMed Central

den Hartog, A.G; Bovens, S.M; Koning, W; Hendrikse, J; Pasterkamp, G; Moll, F.L; de Borst, G.J

2011-01-01

Introduction: In patients with carotid artery stenosis histological plaque composition is associated with plaque stability and with presenting symptomatology. Preferentially, plaque vulnerability should be taken into account in pre-operative work-up of patients with severe carotid artery stenosis. However, currently no appropriate and conclusive (non-) invasive technique to differentiate between the high and low risk carotid artery plaque in vivo is available. We propose that 7 Tesla human high resolution MRI scanning will visualize carotid plaque characteristics more precisely and will enable correlation of these specific components with cerebral damage. Study objective: The aim of the PlaCD-7T study is 1: to correlate 7T imaging with carotid plaque histology (gold standard); and 2: to correlate plaque characteristics with cerebral damage ((clinically silent) cerebral (micro) infarcts or bleeds) on 7 Tesla high resolution (HR) MRI. Design: We propose a single center prospective study for either symptomatic or asymptomatic patients with haemodynamic significant (70%) stenosis of at least one of the carotid arteries. The Athero-Express (AE) biobank histological analysis will be derived according to standard protocol. Patients included in the AE and our prospective study will undergo a pre-operative 7 Tesla HR-MRI scan of both the head and neck area. Discussion: We hypothesize that the 7 Tesla MRI scanner will allow early identification of high risk carotid plaques being associated with micro infarcted cerebral areas, and will thus be able to identify patients with a high risk of periprocedural stroke, by identification of surrogate measures of increased cardiovascular risk. PMID:22294972

Anxiety can significantly explain bolus perception in the context of hypotensive esophageal motility: Results of a large multicenter study in asymptomatic individuals.

PubMed

Cisternas, D; Scheerens, C; Omari, T; Monrroy, H; Hani, A; Leguizamo, A; Bilder, C; Ditaranto, A; Ruiz de León, A; Pérez de la Serna, J; Valdovinos, M A; Coello, R; Abrahao, L; Remes-Troche, J; Meixueiro, A; Zavala, M A; Marin, I; Serra, J

2017-09-01

Previous studies have not been able to correlate manometry findings with bolus perception. The aim of this study was to evaluate correlation of different variables, including traditional manometric variables (at diagnostic and extreme thresholds), esophageal shortening, bolus transit, automated impedance manometry (AIM) metrics and mood with bolus passage perception in a large cohort of asymptomatic individuals. High resolution manometry (HRM) was performed in healthy individuals from nine centers. Perception was evaluated using a 5-point Likert scale. Anxiety was evaluated using Hospitalized Anxiety and Depression scale (HAD). Subgroup analysis was also performed classifying studies into normal, hypotensive, vigorous, and obstructive patterns. One hundred fifteen studies were analyzed (69 using HRM and 46 using high resolution impedance manometry (HRIM); 3.5% swallows in 9.6% of volunteers were perceived. There was no correlation of any of the traditional HRM variables, esophageal shortening, AIM metrics nor bolus transit with perception scores. There was no HRM variable showing difference in perception when comparing normal vs extreme values (percentile 1 or 99). Anxiety but not depression was correlated with perception. Among hypotensive pattern, anxiety was a strong predictor of variance in perception (R 2 up to .70). Bolus perception is less common than abnormal motility among healthy individuals. Neither esophageal motor function nor bolus dynamics evaluated with several techniques seems to explain differences in bolus perception. Different mechanisms seem to be relevant in different manometric patterns. Anxiety is a significant predictor of bolus perception in the context of hypotensive motility. © 2017 John Wiley & Sons Ltd.

The electrolytic inferior vena cava model (EIM) to study thrombogenesis and thrombus resolution with continuous blood flow in the mouse

PubMed Central

Diaz, Jose A.; Alvarado, Christine M.; Wrobleski, Shirley K.; Slack, Dallas W.; Hawley, Angela E.; Farris, Diana M.; Henke, Peter K.; Wakefield, Thomas W.; Myers, Daniel D.

2016-01-01

Summary Previously, we presented the electrolytic inferior vena cava (IVC) model (EIM) during acute venous thrombosis (VT). Here, we present our evaluation of the EIM for chronic VT time points in order to determine whether this model allows for the study of thrombus resolution. C57BU6 mice (n=191) were utilised. In this model a copper-wire, inserted into a 25-gauge needle, is placed in the distal IVC and another subcutaneously. An electrical current (250 µAmp/15 minutes) activates the endothelial cells, inducing thrombogenesis. Ultrasound, thrombus weight (TW), vein wall leukocyte counts, vein wall thickness/fibrosis scoring, thrombus area and soluble P-selectin (sP-sel) were performed at baseline, days 1, 2, 4, 6, 9, 11 and 14, post EIM. A correlation between TW and sP-sel was also determined. A thrombus formed in each mouse undergoing EIM. Blood flow was documented by ultrasound at all time points. IVC thrombus size increased up to day 2 and then decreased over time, as shown by ultrasound, TW, and sP-sel levels. TW and sP-sel showed a strong positive correlation (r=0.48, p<0.0002). Vein wall neutrophils were the most common cell type present in acute VT (up to day 2) with monocytes becoming the most prevalent in chronic VT (from day 6 to day 14). Thrombus resolution was demonstrated by ultrasound, TW and thrombus area. In conclusion, the EIM produces a non-occlusive and consistent IVC thrombus, in the presence of constant blood flow, allowing for the study of VT at both acute and chronic time points. Thrombus resolution was demonstrated by all modalities utilised in this study. PMID:23571406

Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.

PubMed

Posner, S; Zheng, J; Wood, R K; Shimpi, R A; Hartwig, M G; Chow, S-C; Leiman, D A

2018-05-01

Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients with advanced lung disease and are associated with graft dysfunction following lung transplantation. As a result, many transplant centers perform esophageal function testing as part of the wait-listing process but guidelines for testing in this population are lacking. The aim of this study is to describe whether symptoms of gastroesophageal reflux correlate with abnormal results on pH-metry and high-resolution manometry and can be used to identify those who require testing. We performed a retrospective cohort study of 226 lung transplant candidates referred for high-resolution manometry and pH-metry over a 12-month period in 2015. Demographic data, results of a standard symptom questionnaire and details of esophageal function testing were obtained. Associations between the presence of symptoms and test results were analyzed using Fisher's exact tests and multivariable logistic regression. The most common lung disease diagnosis was interstitial lung disease (N = 131, 58%). Abnormal pH-metry was seen in 116 (51%) patients and the presence of symptoms was significantly associated with an abnormal study (p < 0.01). Dysmotility was found in 98 (43%) patients, with major peristaltic or esophageal outflow disorders in 45 (20%) patients. Symptoms were not correlated with findings on esophageal high-resolution manometry. Fifteen of 25 (60%) asymptomatic patients had an abnormal manometry or pH-metry. These results demonstrate that in patients with advanced lung disease, symptoms of gastroesophageal reflux increase the likelihood of elevated acid exposure on pH-metry but were not associated with dysmotility. Given the proportion of asymptomatic patients with abnormal studies and associated post-transplant risks, a practice of universal high-resolution manometry and pH-metry testing in this population is justifiable.

Correlative Microscopy Combining Secondary Ion Mass Spectrometry and Electron Microscopy: Comparison of Intensity-Hue-Saturation and Laplacian Pyramid Methods for Image Fusion.

PubMed

Vollnhals, Florian; Audinot, Jean-Nicolas; Wirtz, Tom; Mercier-Bonin, Muriel; Fourquaux, Isabelle; Schroeppel, Birgit; Kraushaar, Udo; Lev-Ram, Varda; Ellisman, Mark H; Eswara, Santhana

2017-10-17

Correlative microscopy combining various imaging modalities offers powerful insights into obtaining a comprehensive understanding of physical, chemical, and biological phenomena. In this article, we investigate two approaches for image fusion in the context of combining the inherently lower-resolution chemical images obtained using secondary ion mass spectrometry (SIMS) with the high-resolution ultrastructural images obtained using electron microscopy (EM). We evaluate the image fusion methods with three different case studies selected to broadly represent the typical samples in life science research: (i) histology (unlabeled tissue), (ii) nanotoxicology, and (iii) metabolism (isotopically labeled tissue). We show that the intensity-hue-saturation fusion method often applied for EM-sharpening can result in serious image artifacts, especially in cases where different contrast mechanisms interplay. Here, we introduce and demonstrate Laplacian pyramid fusion as a powerful and more robust alternative method for image fusion. Both physical and technical aspects of correlative image overlay and image fusion specific to SIMS-based correlative microscopy are discussed in detail alongside the advantages, limitations, and the potential artifacts. Quantitative metrics to evaluate the results of image fusion are also discussed.

Multi-scale properties of large eddy simulations: correlations between resolved-scale velocity-field increments and subgrid-scale quantities

NASA Astrophysics Data System (ADS)

Linkmann, Moritz; Buzzicotti, Michele; Biferale, Luca

2018-06-01

We provide analytical and numerical results concerning multi-scale correlations between the resolved velocity field and the subgrid-scale (SGS) stress-tensor in large eddy simulations (LES). Following previous studies for Navier-Stokes equations, we derive the exact hierarchy of LES equations governing the spatio-temporal evolution of velocity structure functions of any order. The aim is to assess the influence of the subgrid model on the inertial range intermittency. We provide a series of predictions, within the multifractal theory, for the scaling of correlation involving the SGS stress and we compare them against numerical results from high-resolution Smagorinsky LES and from a-priori filtered data generated from direct numerical simulations (DNS). We find that LES data generally agree very well with filtered DNS results and with the multifractal prediction for all leading terms in the balance equations. Discrepancies are measured for some of the sub-leading terms involving cross-correlation between resolved velocity increments and the SGS tensor or the SGS energy transfer, suggesting that there must be room to improve the SGS modelisation to further extend the inertial range properties for any fixed LES resolution.

Comparing efficacy of different taxonomic resolutions and surrogates in detecting changes in soft bottom assemblages due to coastal defence structures.

PubMed

Bertasi, Fabio; Colangelo, Marina Antonia; Colosio, Francesco; Gregorio, Gianni; Abbiati, Marco; Ceccherelli, Victor Ugo

2009-05-01

Sandy shores on the West coast of the North Adriatic Sea are extensively protected by different types of defence structures to prevent coastal erosion. Coastal defence schemes modify the hydrodynamic regime, the sediment structure and composition thus affecting the benthic assemblages. This study examines the effectiveness in detecting changes in soft bottom assemblages caused by coastal defence structures by using different levels of taxonomic resolution, polychaetes and/or bivalves as surrogates and different data transformations. A synoptic analyses of three datasets of subtidal benthic macrofauna used in studies aimed at assessing the impact of breakwaters along the North Adriatic coast has been done. Analyses of similarities and correlations between distance matrices were done using matrices with different levels of taxonomic resolution, and with polychaetes or bivalves data alone. Lentidium mediterraneum was the most abundant species in all datasets. Its abundance was not consistently related to the presence of defence structures. Moreover, distribution patterns of L. mediterraneum were masking the structure of the whole macrofaunal assemblages. Removal of L. mediterraneum from the datasets allowed the detection of changes in benthic assemblages due to coastal defences. Analyses on different levels of taxonomic resolution showed that the level of family maintained sufficient information to detect the impacts of coastal defence structures on benthic assemblages. Moreover, the outcomes depended on the transformation used. Patterns of distribution of bivalves, used as surrogates, showed low correlations with the patterns of the total macrofaunal species assemblages. Patterns of polychaetes, if identified to the species or genus level showed higher correlations with the whole dataset. However, the identification of polychaetes to species and genus level is as costly as the identification of all macrobenthic taxa at family level. This study provided additional evidences that taxonomic sufficiency is a useful tool in environmental monitoring, also in investigations on the impacts of coastal defence structures on subtidal macrofauna. The use of coarser taxonomic level, being time-efficient, would allow improving sampling designs of monitoring programs by increasing replication in space and time and by allowing long term monitoring studies.

A LORETA study of mental time travel: similar and distinct electrophysiological correlates of re-experiencing past events and pre-experiencing future events.

PubMed

Lavallee, Christina F; Persinger, Michael A

2010-12-01

Previous studies exploring mental time travel paradigms with functional neuroimaging techniques have uncovered both common and distinct neural correlates of re-experiencing past events or pre-experiencing future events. A gap in the mental time travel literature exists, as paradigms have not explored the affective component of re-experiencing past episodic events; this study explored this sparsely researched area. The present study employed standardized low resolution electromagnetic tomography (sLORETA) to identify electrophysiological correlates of re-experience affect-laden and non-affective past events, as well as pre-experiencing a future anticipated event. Our results confirm previous research and are also novel in that we illustrate common and distinct electrophysiological correlates of re-experiencing affective episodic events. Furthermore, research from this experiment yields results outlining a pattern of activation in the frontal and temporal regions is correlated with the time frame of past or future events subjects imagined. Copyright © 2010 Elsevier Inc. All rights reserved.

The spatial sensitivity of the spectral diversity-biodiversity relationship: an experimental test in a prairie grassland.

PubMed

Wang, Ran; Gamon, John A; Cavender-Bares, Jeannine; Townsend, Philip A; Zygielbaum, Arthur I

2018-03-01

Remote sensing has been used to detect plant biodiversity in a range of ecosystems based on the varying spectral properties of different species or functional groups. However, the most appropriate spatial resolution necessary to detect diversity remains unclear. At coarse resolution, differences among spectral patterns may be too weak to detect. In contrast, at fine resolution, redundant information may be introduced. To explore the effect of spatial resolution, we studied the scale dependence of spectral diversity in a prairie ecosystem experiment at Cedar Creek Ecosystem Science Reserve, Minnesota, USA. Our study involved a scaling exercise comparing synthetic pixels resampled from high-resolution images within manipulated diversity treatments. Hyperspectral data were collected using several instruments on both ground and airborne platforms. We used the coefficient of variation (CV) of spectral reflectance in space as the indicator of spectral diversity and then compared CV at different scales ranging from 1 mm 2 to 1 m 2 to conventional biodiversity metrics, including species richness, Shannon's index, Simpson's index, phylogenetic species variation, and phylogenetic species evenness. In this study, higher species richness plots generally had higher CV. CV showed higher correlations with Shannon's index and Simpson's index than did species richness alone, indicating evenness contributed to the spectral diversity. Correlations with species richness and Simpson's index were generally higher than with phylogenetic species variation and evenness measured at comparable spatial scales, indicating weaker relationships between spectral diversity and phylogenetic diversity metrics than with species diversity metrics. High resolution imaging spectrometer data (1 mm 2 pixels) showed the highest sensitivity to diversity level. With decreasing spatial resolution, the difference in CV between diversity levels decreased and greatly reduced the optical detectability of biodiversity. The optimal pixel size for distinguishing α diversity in these prairie plots appeared to be around 1 mm to 10 cm, a spatial scale similar to the size of an individual herbaceous plant. These results indicate a strong scale-dependence of the spectral diversity-biodiversity relationships, with spectral diversity best able to detect a combination of species richness and evenness, and more weakly detecting phylogenetic diversity. These findings can be used to guide airborne studies of biodiversity and develop more effective large-scale biodiversity sampling methods. ©2018 The Authors Ecological Applications published by Wiley Periodicals, Inc. on behalf of Ecological Society of America.

On the relationship between cumulative correlation coefficients and the quality of crystallographic data sets.

PubMed

Wang, Jimin; Brudvig, Gary W; Batista, Victor S; Moore, Peter B

2017-12-01

In 2012, Karplus and Diederichs demonstrated that the Pearson correlation coefficient CC 1/2 is a far better indicator of the quality and resolution of crystallographic data sets than more traditional measures like merging R-factor or signal-to-noise ratio. More specifically, they proposed that CC 1/2 be computed for data sets in thin shells of increasing resolution so that the resolution dependence of that quantity can be examined. Recently, however, the CC 1/2 values of entire data sets, i.e., cumulative correlation coefficients, have been used as a measure of data quality. Here, we show that the difference in cumulative CC 1/2 value between a data set that has been accurately measured and a data set that has not is likely to be small. Furthermore, structures obtained by molecular replacement from poorly measured data sets are likely to suffer from extreme model bias. © 2017 The Protein Society.

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Pontieu, B.; Martinez-Sykora, J.; McIntosh, S.

Spectral observations of the solar transition region (TR) and corona show broadening of spectral lines beyond what is expected from thermal and instrumental broadening. The remaining non-thermal broadening is significant (5–30 km s{sup −1}) and correlated with intensity. Here we study spectra of the TR Si iv 1403 Å line obtained at high resolution with the Interface Region Imaging Spectrograph (IRIS). We find that the large improvement in spatial resolution (0.″33) of IRIS compared to previous spectrographs (2″) does not resolve the non-thermal line broadening which, in most regions, remains at pre-IRIS levels of about 20 km s{sup −1}. Thismore » invariance to spatial resolution indicates that the processes behind the broadening occur along the line-of-sight (LOS) and/or on spatial scales (perpendicular to the LOS) smaller than 250 km. Both effects appear to play a role. Comparison with IRIS chromospheric observations shows that, in regions where the LOS is more parallel to the field, magneto-acoustic shocks driven from below impact the TR and can lead to significant non-thermal line broadening. This scenario is supported by MHD simulations. While these do not show enough non-thermal line broadening, they do reproduce the long-known puzzling correlation between non-thermal line broadening and intensity. This correlation is caused by the shocks, but only if non-equilibrium ionization is taken into account. In regions where the LOS is more perpendicular to the field, the prevalence of small-scale twist is likely to play a significant role in explaining the invariance and correlation with intensity. (letters)« less

Penalized weighted least-squares approach for low-dose x-ray computed tomography

NASA Astrophysics Data System (ADS)

Wang, Jing; Li, Tianfang; Lu, Hongbing; Liang, Zhengrong

2006-03-01

The noise of low-dose computed tomography (CT) sinogram follows approximately a Gaussian distribution with nonlinear dependence between the sample mean and variance. The noise is statistically uncorrelated among detector bins at any view angle. However the correlation coefficient matrix of data signal indicates a strong signal correlation among neighboring views. Based on above observations, Karhunen-Loeve (KL) transform can be used to de-correlate the signal among the neighboring views. In each KL component, a penalized weighted least-squares (PWLS) objective function can be constructed and optimal sinogram can be estimated by minimizing the objective function, followed by filtered backprojection (FBP) for CT image reconstruction. In this work, we compared the KL-PWLS method with an iterative image reconstruction algorithm, which uses the Gauss-Seidel iterative calculation to minimize the PWLS objective function in image domain. We also compared the KL-PWLS with an iterative sinogram smoothing algorithm, which uses the iterated conditional mode calculation to minimize the PWLS objective function in sinogram space, followed by FBP for image reconstruction. Phantom experiments show a comparable performance of these three PWLS methods in suppressing the noise-induced artifacts and preserving resolution in reconstructed images. Computer simulation concurs with the phantom experiments in terms of noise-resolution tradeoff and detectability in low contrast environment. The KL-PWLS noise reduction may have the advantage in computation for low-dose CT imaging, especially for dynamic high-resolution studies.

The Relationship Between Spectral Modulation Detection and Speech Recognition: Adult Versus Pediatric Cochlear Implant Recipients

PubMed Central

Noble, Jack H.; Camarata, Stephen M.; Sunderhaus, Linsey W.; Dwyer, Robert T.; Dawant, Benoit M.; Dietrich, Mary S.; Labadie, Robert F.

2018-01-01

Adult cochlear implant (CI) recipients demonstrate a reliable relationship between spectral modulation detection and speech understanding. Prior studies documenting this relationship have focused on postlingually deafened adult CI recipients—leaving an open question regarding the relationship between spectral resolution and speech understanding for adults and children with prelingual onset of deafness. Here, we report CI performance on the measures of speech recognition and spectral modulation detection for 578 CI recipients including 477 postlingual adults, 65 prelingual adults, and 36 prelingual pediatric CI users. The results demonstrated a significant correlation between spectral modulation detection and various measures of speech understanding for 542 adult CI recipients. For 36 pediatric CI recipients, however, there was no significant correlation between spectral modulation detection and speech understanding in quiet or in noise nor was spectral modulation detection significantly correlated with listener age or age at implantation. These findings suggest that pediatric CI recipients might not depend upon spectral resolution for speech understanding in the same manner as adult CI recipients. It is possible that pediatric CI users are making use of different cues, such as those contained within the temporal envelope, to achieve high levels of speech understanding. Further investigation is warranted to investigate the relationship between spectral and temporal resolution and speech recognition to describe the underlying mechanisms driving peripheral auditory processing in pediatric CI users. PMID:29716437

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Jiali; Swati, F. N. U.; Stein, Michael L.

Regional climate models (RCMs) are a standard tool for downscaling climate forecasts to finer spatial scales. The evaluation of RCMs against observational data is an important step in building confidence in the use of RCMs for future prediction. In addition to model performance in climatological means and marginal distributions, a model’s ability to capture spatio-temporal relationships is important. This study develops two approaches: (1) spatial correlation/variogram for a range of spatial lags, with total monthly precipitation and non-seasonal precipitation components used to assess the spatial variations of precipitation; and (2) spatio-temporal correlation for a wide range of distances, directions, andmore » time lags, with daily precipitation occurrence used to detect the dynamic features of precipitation. These measures of spatial and spatio-temporal dependence are applied to a high-resolution RCM run and to the National Center for Environmental Prediction (NCEP)-U.S. Department of Energy (DOE) AMIP II reanalysis data (NCEP-R2), which provides initial and lateral boundary conditions for the RCM. The RCM performs better than NCEP-R2 in capturing both the spatial variations of total and non-seasonal precipitation components and the spatio-temporal correlations of daily precipitation occurrences, which are related to dynamic behaviors of precipitating systems. The improvements are apparent not just at resolutions finer than that of NCEP-R2, but also when the RCM and observational data are aggregated to the resolution of NCEP-R2.« less

Scales of snow depth variability in high elevation rangeland sagebrush

NASA Astrophysics Data System (ADS)

Tedesche, Molly E.; Fassnacht, Steven R.; Meiman, Paul J.

2017-09-01

In high elevation semi-arid rangelands, sagebrush and other shrubs can affect transport and deposition of wind-blown snow, enabling the formation of snowdrifts. Datasets from three field experiments were used to investigate the scales of spatial variability of snow depth around big mountain sagebrush ( Artemisia tridentata Nutt.) at a high elevation plateau rangeland in North Park, Colorado, during the winters of 2002, 2003, and 2008. Data were collected at multiple resolutions (0.05 to 25 m) and extents (2 to 1000 m). Finer scale data were collected specifically for this study to examine the correlation between snow depth, sagebrush microtopography, the ground surface, and the snow surface, as well as the temporal consistency of snow depth patterns. Variograms were used to identify the spatial structure and the Moran's I statistic was used to determine the spatial correlation. Results show some temporal consistency in snow depth at several scales. Plot scale snow depth variability is partly a function of the nature of individual shrubs, as there is some correlation between the spatial structure of snow depth and sagebrush, as well as between the ground and snow depth. The optimal sampling resolution appears to be 25-cm, but over a large area, this would require a multitude of samples, and thus a random stratified approach is recommended with a fine measurement resolution of 5-cm.

A review of supervised object-based land-cover image classification

NASA Astrophysics Data System (ADS)

Ma, Lei; Li, Manchun; Ma, Xiaoxue; Cheng, Liang; Du, Peijun; Liu, Yongxue

2017-08-01

Object-based image classification for land-cover mapping purposes using remote-sensing imagery has attracted significant attention in recent years. Numerous studies conducted over the past decade have investigated a broad array of sensors, feature selection, classifiers, and other factors of interest. However, these research results have not yet been synthesized to provide coherent guidance on the effect of different supervised object-based land-cover classification processes. In this study, we first construct a database with 28 fields using qualitative and quantitative information extracted from 254 experimental cases described in 173 scientific papers. Second, the results of the meta-analysis are reported, including general characteristics of the studies (e.g., the geographic range of relevant institutes, preferred journals) and the relationships between factors of interest (e.g., spatial resolution and study area or optimal segmentation scale, accuracy and number of targeted classes), especially with respect to the classification accuracy of different sensors, segmentation scale, training set size, supervised classifiers, and land-cover types. Third, useful data on supervised object-based image classification are determined from the meta-analysis. For example, we find that supervised object-based classification is currently experiencing rapid advances, while development of the fuzzy technique is limited in the object-based framework. Furthermore, spatial resolution correlates with the optimal segmentation scale and study area, and Random Forest (RF) shows the best performance in object-based classification. The area-based accuracy assessment method can obtain stable classification performance, and indicates a strong correlation between accuracy and training set size, while the accuracy of the point-based method is likely to be unstable due to mixed objects. In addition, the overall accuracy benefits from higher spatial resolution images (e.g., unmanned aerial vehicle) or agricultural sites where it also correlates with the number of targeted classes. More than 95.6% of studies involve an area less than 300 ha, and the spatial resolution of images is predominantly between 0 and 2 m. Furthermore, we identify some methods that may advance supervised object-based image classification. For example, deep learning and type-2 fuzzy techniques may further improve classification accuracy. Lastly, scientists are strongly encouraged to report results of uncertainty studies to further explore the effects of varied factors on supervised object-based image classification.

Structure of Ce2RhIn8: an example of complementary use of high-resolution neutron powder diffraction and reciprocal-space mapping to study complex materials.

PubMed

Moshopoulou, E G; Ibberson, R M; Sarrao, J L; Thompson, J D; Fisk, Z

2006-04-01

The room-temperature crystal structure of the heavy fermion antiferromagnet Ce2RhIn8, dicerium rhodium octaindide, has been studied by a combination of high-resolution synchrotron X-ray reciprocal-space mapping of single crystals and high-resolution time-of-flight neutron powder diffraction. The structure is disordered, exhibiting a complex interplay of non-periodic, partially correlated planar defects, coexistence and segregation of polytypic phases (induced by periodic planar ;defects'), mosaicity (i.e. domain misalignment) and non-uniform strain. These effects evolve as a function of temperature in a complicated way, but they remain down to low temperatures. The room-temperature diffraction data are best represented by a complex mixture of two polytypic phases, which are affected by non-periodic, partially correlated planar defects, differ slightly in their tetragonal structures, and exhibit different mosaicities and strain values. Therefore, Ce2RhIn8 approaches the paracrystalline state, rather than the classic crystalline state and thus several of the concepts of conventional single-crystal crystallography are inapplicable. The structural results are discussed in the context of the role of disorder in the heavy-fermion state and in the interplay between superconductivity and magnetism.

Study of the Effect of Temporal Sampling Frequency on DSCOVR Observations Using the GEOS-5 Nature Run Results (Part I): Earths Radiation Budget

NASA Technical Reports Server (NTRS)

Holdaway, Daniel; Yang, Yuekui

2016-01-01

Satellites always sample the Earth-atmosphere system in a finite temporal resolution. This study investigates the effect of sampling frequency on the satellite-derived Earth radiation budget, with the Deep Space Climate Observatory (DSCOVR) as an example. The output from NASA's Goddard Earth Observing System Version 5 (GEOS-5) Nature Run is used as the truth. The Nature Run is a high spatial and temporal resolution atmospheric simulation spanning a two-year period. The effect of temporal resolution on potential DSCOVR observations is assessed by sampling the full Nature Run data with 1-h to 24-h frequencies. The uncertainty associated with a given sampling frequency is measured by computing means over daily, monthly, seasonal and annual intervals and determining the spread across different possible starting points. The skill with which a particular sampling frequency captures the structure of the full time series is measured using correlations and normalized errors. Results show that higher sampling frequency gives more information and less uncertainty in the derived radiation budget. A sampling frequency coarser than every 4 h results in significant error. Correlations between true and sampled time series also decrease more rapidly for a sampling frequency less than 4 h.

Dislocation Content Measured Via 3D HR-EBSD Near a Grain Boundary in an AlCu Oligocrystal

NASA Technical Reports Server (NTRS)

Ruggles, Timothy; Hochhalter, Jacob; Homer, Eric

2016-01-01

Interactions between dislocations and grain boundaries are poorly understood and crucial to mesoscale plasticity modeling. Much of our understanding of dislocation-grain boundary interaction comes from atomistic simulations and TEM studies, both of which are extremely limited in scale. High angular resolution EBSD-based continuum dislocation microscopy provides a way of measuring dislocation activity at length scales and accuracies relevant to crystal plasticity, but it is limited as a two-dimensional technique, meaning the character of the grain boundary and the complete dislocation activity is difficult to recover. However, the commercialization of plasma FIB dual-beam microscopes have made 3D EBSD studies all the more feasible. The objective of this work is to apply high angular resolution cross correlation EBSD to a 3D EBSD data set collected by serial sectioning in a FIB to characterize dislocation interaction with a grain boundary. Three dimensional high angular resolution cross correlation EBSD analysis was applied to an AlCu oligocrystal to measure dislocation densities around a grain boundary. Distortion derivatives associated with the plasma FIB serial sectioning were higher than expected, possibly due to geometric uncertainty between layers. Future work will focus on mitigating the geometric uncertainty and examining more regions of interest along the grain boundary to glean information on dislocation-grain boundary interaction.

Science with High Spatial Resolution Far-Infrared Data

NASA Technical Reports Server (NTRS)

Terebey, Susan (Editor); Mazzarella, Joseph M. (Editor)

1994-01-01

The goal of this workshop was to discuss new science and techniques relevant to high spatial resolution processing of far-infrared data, with particular focus on high resolution processing of IRAS data. Users of the maximum correlation method, maximum entropy, and other resolution enhancement algorithms applicable to far-infrared data gathered at the Infrared Processing and Analysis Center (IPAC) for two days in June 1993 to compare techniques and discuss new results. During a special session on the third day, interested astronomers were introduced to IRAS HIRES processing, which is IPAC's implementation of the maximum correlation method to the IRAS data. Topics discussed during the workshop included: (1) image reconstruction; (2) random noise; (3) imagery; (4) interacting galaxies; (5) spiral galaxies; (6) galactic dust and elliptical galaxies; (7) star formation in Seyfert galaxies; (8) wavelet analysis; and (9) supernova remnants.

Mapping turbidity in the Charles River, Boston using a high-resolution satellite.

PubMed

Hellweger, Ferdi L; Miller, Will; Oshodi, Kehinde Sarat

2007-09-01

The usability of high-resolution satellite imagery for estimating spatial water quality patterns in urban water bodies is evaluated using turbidity in the lower Charles River, Boston as a case study. Water turbidity was surveyed using a boat-mounted optical sensor (YSI) at 5 m spatial resolution, resulting in about 4,000 data points. The ground data were collected coincidently with a satellite imagery acquisition (IKONOS), which consists of multispectral (R, G, B) reflectance at 1 m resolution. The original correlation between the raw ground and satellite data was poor (R2 = 0.05). Ground data were processed by removing points affected by contamination (e.g., sensor encounters a particle floc), which were identified visually. Also, the ground data were corrected for the memory effect introduced by the sensor's protective casing using an analytical model. Satellite data were processed to remove pixels affected by permanent non-water features (e.g., shoreline). In addition, water pixels within a certain buffer distance from permanent non-water features were removed due to contamination by the adjacency effect. To determine the appropriate buffer distance, a procedure that explicitly considers the distance of pixels to the permanent non-water features was applied. Two automatic methods for removing the effect of temporary non-water features (e.g., boats) were investigated, including (1) creating a water-only mask based on an unsupervised classification and (2) removing (filling) all local maxima in reflectance. After the various processing steps, the correlation between the ground and satellite data was significantly better (R2 = 0.70). The correlation was applied to the satellite image to develop a map of turbidity in the lower Charles River, which reveals large-scale patterns in water clarity. However, the adjacency effect prevented the application of this method to near-shore areas, where high-resolution patterns were expected (e.g., outfall plumes).

Morphological characterization of coral reefs by combining lidar and MBES data: A case study from Yuanzhi Island, South China Sea

NASA Astrophysics Data System (ADS)

Zhang, Kai; Yang, Fanlin; Zhang, Hande; Su, Dianpeng; Li, QianQian

2017-06-01

The correlation between seafloor morphological features and biological complexity has been identified in numerous recent studies. This research focused on the potential for accurate characterization of coral reefs based on high-resolution bathymetry from multiple sources. A standard deviation (STD) based method for quantitatively characterizing terrain complexity was developed that includes robust estimation to correct for irregular bathymetry and a calibration for the depth-dependent variablity of measurement noise. Airborne lidar and shipborne sonar bathymetry measurements from Yuanzhi Island, South China Sea, were merged to generate seamless high-resolution coverage of coral bathymetry from the shoreline to deep water. The new algorithm was applied to the Yuanzhi Island surveys to generate maps of quantitive terrain complexity, which were then compared to in situ video observations of coral abundance. The terrain complexity parameter is significantly correlated with seafloor coral abundance, demonstrating the potential for accurately and efficiently mapping coral abundance through seafloor surveys, including combinations of surveys using different sensors.

Quantitative EEG and Current Source Density Analysis of Combined Antiepileptic Drugs and Dopaminergic Agents in Genetic Epilepsy: Two Case Studies.

PubMed

Emory, Hamlin; Wells, Christopher; Mizrahi, Neptune

2015-07-01

Two adolescent females with absence epilepsy were classified, one as attention deficit and the other as bipolar disorder. Physical and cognitive exams identified hypotension, bradycardia, and cognitive dysfunction. Their initial electroencephalograms (EEGs) were considered slightly slow, but within normal limits. Quantitative EEG (QEEG) data included relative theta excess and low alpha mean frequencies. A combined treatment of antiepileptic drugs with a catecholamine agonist/reuptake inhibitor was sequentially used. Both patients' physical and cognitive functions improved and they have remained seizure free. The clinical outcomes were correlated with statistically significant changes in QEEG measures toward normal Z-scores in both anterior and posterior regions. In addition, low resolution electromagnetic tomography (LORETA) Z-scored source correlation analyses of the initial and treated QEEG data showed normalized patterns, supporting a neuroanatomic resolution. This study presents preliminary evidence for a neurophysiologic approach to patients with absence epilepsy and comorbid disorders and may provide a method for further research. © EEG and Clinical Neuroscience Society (ECNS) 2014.

Authentication of virgin olive oil by a novel curve resolution approach combined with visible spectroscopy.

PubMed

Ferreiro-González, Marta; Barbero, Gerardo F; Álvarez, José A; Ruiz, Antonio; Palma, Miguel; Ayuso, Jesús

2017-04-01

Adulteration of olive oil is not only a major economic fraud but can also have major health implications for consumers. In this study, a combination of visible spectroscopy with a novel multivariate curve resolution method (CR), principal component analysis (PCA) and linear discriminant analysis (LDA) is proposed for the authentication of virgin olive oil (VOO) samples. VOOs are well-known products with the typical properties of a two-component system due to the two main groups of compounds that contribute to the visible spectra (chlorophylls and carotenoids). Application of the proposed CR method to VOO samples provided the two pure-component spectra for the aforementioned families of compounds. A correlation study of the real spectra and the resolved component spectra was carried out for different types of oil samples (n=118). LDA using the correlation coefficients as variables to discriminate samples allowed the authentication of 95% of virgin olive oil samples. Copyright © 2016 Elsevier Ltd. All rights reserved.

Relationship between resolution and accuracy of four intraoral scanners in complete-arch impressions

PubMed Central

Pascual-Moscardó, Agustín; Camps, Isabel

2018-01-01

Background The scanner does not measure the dental surface continually. Instead, it generates a point cloud, and these points are then joined to form the scanned object. This approximation will depend on the number of points generated (resolution), which can lead to low accuracy (trueness and precision) when fewer points are obtained. The purpose of this study is to determine the resolution of four intraoral digital imaging systems and to demonstrate the relationship between accuracy and resolution of the intraoral scanner in impressions of a complete dental arch. Material and Methods A master cast of the complete maxillary arch was prepared with different dental preparations. Using four digital impression systems, the cast was scanned inside of a black methacrylate box, obtaining a total of 40 digital impressions from each scanner. The resolution was obtained by dividing the number of points of each digital impression by the total surface area of the cast. Accuracy was evaluated using a three-dimensional measurement software, using the “best alignment” method of the casts with a highly faithful reference model obtained from an industrial scanner. Pearson correlation was used for statistical analysis of the data. Results Of the intraoral scanners, Omnicam is the system with the best resolution, with 79.82 points per mm2, followed by True Definition with 54.68 points per mm2, Trios with 41.21 points per mm2, and iTero with 34.20 points per mm2. However, the study found no relationship between resolution and accuracy of the study digital impression systems (P >0.05), except for Omnicam and its precision. Conclusions The resolution of the digital impression systems has no relationship with the accuracy they achieve in the impression of a complete dental arch. The study found that the Omnicam scanner is the system that obtains the best resolution, and that as the resolution increases, its precision increases. Key words:Trueness, precision, accuracy, resolution, intraoral scanner, digital impression. PMID:29750097

Diffraction-Limited Plenoptic Imaging with Correlated Light

NASA Astrophysics Data System (ADS)

Pepe, Francesco V.; Di Lena, Francesco; Mazzilli, Aldo; Edrei, Eitan; Garuccio, Augusto; Scarcelli, Giuliano; D'Angelo, Milena

2017-12-01

Traditional optical imaging faces an unavoidable trade-off between resolution and depth of field (DOF). To increase resolution, high numerical apertures (NAs) are needed, but the associated large angular uncertainty results in a limited range of depths that can be put in sharp focus. Plenoptic imaging was introduced a few years ago to remedy this trade-off. To this aim, plenoptic imaging reconstructs the path of light rays from the lens to the sensor. However, the improvement offered by standard plenoptic imaging is practical and not fundamental: The increased DOF leads to a proportional reduction of the resolution well above the diffraction limit imposed by the lens NA. In this Letter, we demonstrate that correlation measurements enable pushing plenoptic imaging to its fundamental limits of both resolution and DOF. Namely, we demonstrate maintaining the imaging resolution at the diffraction limit while increasing the depth of field by a factor of 7. Our results represent the theoretical and experimental basis for the effective development of promising applications of plenoptic imaging.

Diffraction-Limited Plenoptic Imaging with Correlated Light.

PubMed

Pepe, Francesco V; Di Lena, Francesco; Mazzilli, Aldo; Edrei, Eitan; Garuccio, Augusto; Scarcelli, Giuliano; D'Angelo, Milena

2017-12-15

Traditional optical imaging faces an unavoidable trade-off between resolution and depth of field (DOF). To increase resolution, high numerical apertures (NAs) are needed, but the associated large angular uncertainty results in a limited range of depths that can be put in sharp focus. Plenoptic imaging was introduced a few years ago to remedy this trade-off. To this aim, plenoptic imaging reconstructs the path of light rays from the lens to the sensor. However, the improvement offered by standard plenoptic imaging is practical and not fundamental: The increased DOF leads to a proportional reduction of the resolution well above the diffraction limit imposed by the lens NA. In this Letter, we demonstrate that correlation measurements enable pushing plenoptic imaging to its fundamental limits of both resolution and DOF. Namely, we demonstrate maintaining the imaging resolution at the diffraction limit while increasing the depth of field by a factor of 7. Our results represent the theoretical and experimental basis for the effective development of promising applications of plenoptic imaging.

Inflammatory Papillitis in Uveitis: Response to Treatment and Use of Optic Nerve Optical Coherence Tomography for Monitoring.

PubMed

Cho, Heeyoon; Pillai, Parvathy; Nicholson, Laura; Sobrin, Lucia

2016-01-01

To describe the clinical course of uveitis-associated inflammatory papillitis and evaluate the utility and reproducibility of optic nerve spectral domain optical coherence tomography (SD-OCT). Data on 22 eyes of 14 patients with uveitis-related papillitis and optic nerve imaging were reviewed. SD-OCT measure reproducibility was determined and parameters were compared in active vs. inactive uveitis. Papillitis resolution lagged behind uveitis resolution in three patients. For SD-OCT measures, the intraclass correlation coefficients were 99.1-100% and 86.9-100% for intraobserver and interobserver reproducibility, respectively. All SD-OCT optic nerve measures except inferior and nasal peripapillary retinal thicknesses were significantly higher in active vs. inactive uveitis after correction for multiple hypotheses testing. Mean optic nerve central thickness decreased from 545.1 to 362.9 µm (p = 0.01). Resolution of inflammatory papillitis can lag behind resolution of uveitis. SD-OCT assessment of papillitis is reproducible and correlates with presence vs. resolution of uveitis.

PLACD-7T Study: Atherosclerotic Carotid Plaque Components Correlated with Cerebral Damage at 7 Tesla Magnetic Resonance Imaging.

PubMed

den Hartog, A G; Bovens, S M; Koning, W; Hendrikse, J; Pasterkamp, G; Moll, F L; de Borst, G J

2011-02-01

In patients with carotid artery stenosis histological plaque composition is associated with plaque stability and with presenting symptomatology. Preferentially, plaque vulnerability should be taken into account in pre-operative work-up of patients with severe carotid artery stenosis. However, currently no appropriate and conclusive (non-) invasive technique to differentiate between the high and low risk carotid artery plaque in vivo is available. We propose that 7 Tesla human high resolution MRI scanning will visualize carotid plaque characteristics more precisely and will enable correlation of these specific components with cerebral damage. The aim of the PlaCD-7T study is 1: to correlate 7T imaging with carotid plaque histology (gold standard); and 2: to correlate plaque characteristics with cerebral damage ((clinically silent) cerebral (micro) infarcts or bleeds) on 7 Tesla high resolution (HR) MRI. We propose a single center prospective study for either symptomatic or asymptomatic patients with haemodynamic significant (70%) stenosis of at least one of the carotid arteries. The Athero-Express (AE) biobank histological analysis will be derived according to standard protocol. Patients included in the AE and our prospective study will undergo a pre-operative 7 Tesla HR-MRI scan of both the head and neck area. We hypothesize that the 7 Tesla MRI scanner will allow early identification of high risk carotid plaques being associated with micro infarcted cerebral areas, and will thus be able to identify patients with a high risk of periprocedural stroke, by identification of surrogate measures of increased cardiovascular risk.

New opportunities in the study of in-medium nuclear properties with FAZIA

NASA Astrophysics Data System (ADS)

Gruyer, Diego; Frankland, John D.

2017-11-01

In this contribution we investigate the capabilities (resolution and efficiency) of the FAZIA demonstrator, with a particular emphasis on light cluster structure studies (excited state energy, width, and spin) and emitting source characterization (temperature and density), using multi-particle correlations. This study has been performed on simulated ^{32}{S}+^{12} C collisions from 25 to 80MeV/A.

Epilepsy After Resolution of Presumed Childhood Encephalitis.

PubMed

Rismanchi, Neggy; Gold, Jeffrey J; Sattar, Shifteh; Glaser, Carol A; Sheriff, Heather; Proudfoot, James; Mower, Andrew; Crawford, John R; Nespeca, Mark; Wang, Sonya G

2015-07-01

To evaluate factors associated with the development of epilepsy after resolution of presumed childhood encephalitis. A total of 217 patients with suspected encephalitis who met criteria for the California Encephalitis Project were identified. Evaluable outcome information was available for 99 patients (40 girls, 59 boys, ages 2 months to 17 years) without preexisting neurological conditions, including prior seizures or abnormal brain magnetic resonance imaging scans. We identified factors correlated with the development of epilepsy after resolution of the acute illness. Development of epilepsy was correlated with the initial presenting sign of seizure (P < 0.001). With each additional antiepileptic drug used to control seizures, the odds ratio of developing epilepsy was increased twofold (P < 0.001). An abnormal electroencephalograph (P < 0.05) and longer hospital duration (median of 8 versus 21 days) also correlated with development of epilepsy (P < 0.01). The need for medically induced coma was associated with epilepsy (P < 0.001). Seizures in those patients were particularly refractory, often requiring longer than 24 hours to obtain seizure control. Individuals who required antiepileptic drugs at discharge (P < 0.001) or were readmitted after their acute illness (P < 0.001) were more likely to develop epilepsy. Of our patients who were able to wean antiepileptic drugs after being started during hospitalization, 42% were successfully tapered off within 6 months. Limited data are available on the risk of developing epilepsy after childhood encephalitis. This is the first study that not only identifies risk factors for the development of epilepsy, but also provides data regarding the success rate of discontinuing antiepileptic medication after resolution of encephalitis. Copyright © 2015 Elsevier Inc. All rights reserved.

Correlative Single-Molecule Localization Microscopy and Confocal Microscopy.

PubMed

Soeller, Christian; Hou, Yufeng; Jayasinghe, Isuru D; Baddeley, David; Crossman, David

2017-01-01

Single-molecule localization microscopy allows the ability to image fluorescence labeled molecular targets at nanoscale resolution. However, for many biological questions the ability to provide tissue and cellular context in addition to these high resolution data is eminently informative. Here, we describe a procedure to achieve this aim by correlatively imaging human cardiac tissue first at the nanoscale with direct stochastic optical reconstruction microscopy (dSTORM) and then at the diffraction limit with conventional confocal microscopy.

Chaotic Brillouin optical correlation-domain analysis

NASA Astrophysics Data System (ADS)

Zhang, Jianzhong; Zhang, Mingtao; Zhang, Mingjiang; Liu, Yi; Feng, Changkun; Wang, Yahui; Wang, Yuncai

2018-04-01

We propose and experimentally demonstrate a chaotic Brillouin optical correlation-domain analysis (BOCDA) system for distributed fiber sensing. The utilization of the chaotic laser with low coherent state ensures high spatial resolution. The experimental results demonstrate a 3.92-cm spatial resolution over a 906-m measurement range. The uncertainty in the measurement of the local Brillouin frequency shift is 1.2MHz. The measurement signal-to-noise ratio is given, which is agreement with the theoretical value.

Effect of combined digital imaging parameters on endodontic file measurements.

PubMed

de Oliveira, Matheus Lima; Pinto, Geraldo Camilo de Souza; Ambrosano, Glaucia Maria Bovi; Tosoni, Guilherme Monteiro

2012-10-01

This study assessed the effect of the combination of a dedicated endodontic filter, spatial resolution, and contrast resolution on the determination of endodontic file lengths. Forty extracted single-rooted teeth were x-rayed with K-files (ISO size 10 and 15) in the root canals. Images were acquired using the VistaScan system (Dürr Dental, Beitigheim-Bissingen, Germany) under different combining parameters of spatial resolution (10 and 25 line pairs per millimeter [lp/mm]) and contrast resolution (8- and 16-bit depths). Subsequently, a dedicated endodontic filter was applied on the 16-bit images, creating 2 additional parameters. Six observers measured the length of the endodontic files in the root canals using the software that accompanies the system. The mean values of the actual file lengths and the measurements of the radiographic images were submitted to 1-way analysis of variance and the Tukey test at a level of significance of 5%. The intraobserver reproducibility was assessed by the intraclass correlation coefficient. All combined image parameters showed excellent intraobserver agreement with intraclass correlation coefficient means higher than 0.98. The imaging parameter of 25 lp/mm and 16 bit associated with the use of the endodontic filter did not differ significantly from the actual file lengths when both file sizes were analyzed together or separately (P > .05). When the size 15 file was evaluated separately, only 8-bit images differed significantly from the actual file lengths (P ≤ .05). The combination of an endodontic filter with high spatial resolution and high contrast resolution is recommended for the determination of file lengths when using storage phosphor plates. Copyright © 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

An fMRI Study of the Social Competition in Healthy Subjects

ERIC Educational Resources Information Center

Polosan, M.; Baciu, M.; Cousin, E.; Perrone, M.; Pichat, C.; Bougerol, T.

2011-01-01

Social interaction requires the ability to infer another person's mental state (Theory of Mind, ToM) and also executive functions. This fMRI study aimed to identify the cerebral correlates activated by ToM during a specific social interaction, the human-human competition. In this framework, we tested a conflict resolution task (Stroop) adapted to…

Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature.

PubMed

Korstanje, Ron; Ryan, Jennifer L; Savage, Holly S; Lyons, Bonnie L; Kane, Kevin G; Sukoff Rizzo, Stacey J

2017-09-01

Previous studies with continuous glucose monitoring in mice have been limited to several days or weeks, with the mouse's physical attachment to the equipment affecting behavior and measurements. In the current study, we measured blood glucose and body temperature at 10-second intervals for 12 weeks in a cohort of NOD/ShiLtJ female mice using wireless telemetry. This allowed us to obtain a high-resolution profile of the circadian rhythm of these two parameters and the onset of hyperglycemic development in real time. The most striking observations were the elevated nocturnal concentrations of glucose into the diabetic range days before elevations in diurnal glucose (when glucose concentrations are historically measured) and the strong, negative correlation between elevated blood glucose concentrations and body temperature with a steady decline of the body temperature with diabetes development. Taken together, this technological advancement provides improved resolution in the study of the disease trajectory of diabetes in mouse models, including relevant translatability to the current technologies of continuous glucose monitoring now regularly used in patients. Copyright © 2017 Endocrine Society.

Effect of image resolution manipulation in rearfoot angle measurements obtained with photogrammetry

PubMed Central

Sacco, I.C.N.; Picon, A.P.; Ribeiro, A.P.; Sartor, C.D.; Camargo-Junior, F.; Macedo, D.O.; Mori, E.T.T.; Monte, F.; Yamate, G.Y.; Neves, J.G.; Kondo, V.E.; Aliberti, S.

2012-01-01

The aim of this study was to investigate the influence of image resolution manipulation on the photogrammetric measurement of the rearfoot static angle. The study design was that of a reliability study. We evaluated 19 healthy young adults (11 females and 8 males). The photographs were taken at 1536 pixels in the greatest dimension, resized into four different resolutions (1200, 768, 600, 384 pixels) and analyzed by three equally trained examiners on a 96-pixels per inch (ppi) screen. An experienced physiotherapist marked the anatomic landmarks of rearfoot static angles on two occasions within a 1-week interval. Three different examiners had marked angles on digital pictures. The systematic error and the smallest detectable difference were calculated from the angle values between the image resolutions and times of evaluation. Different resolutions were compared by analysis of variance. Inter- and intra-examiner reliability was calculated by intra-class correlation coefficients (ICC). The rearfoot static angles obtained by the examiners in each resolution were not different (P > 0.05); however, the higher the image resolution the better the inter-examiner reliability. The intra-examiner reliability (within a 1-week interval) was considered to be unacceptable for all image resolutions (ICC range: 0.08-0.52). The whole body image of an adult with a minimum size of 768 pixels analyzed on a 96-ppi screen can provide very good inter-examiner reliability for photogrammetric measurements of rearfoot static angles (ICC range: 0.85-0.92), although the intra-examiner reliability within each resolution was not acceptable. Therefore, this method is not a proper tool for follow-up evaluations of patients within a therapeutic protocol. PMID:22911379

Effect of image resolution manipulation in rearfoot angle measurements obtained with photogrammetry.

PubMed

Sacco, I C N; Picon, A P; Ribeiro, A P; Sartor, C D; Camargo-Junior, F; Macedo, D O; Mori, E T T; Monte, F; Yamate, G Y; Neves, J G; Kondo, V E; Aliberti, S

2012-09-01

The aim of this study was to investigate the influence of image resolution manipulation on the photogrammetric measurement of the rearfoot static angle. The study design was that of a reliability study. We evaluated 19 healthy young adults (11 females and 8 males). The photographs were taken at 1536 pixels in the greatest dimension, resized into four different resolutions (1200, 768, 600, 384 pixels) and analyzed by three equally trained examiners on a 96-pixels per inch (ppi) screen. An experienced physiotherapist marked the anatomic landmarks of rearfoot static angles on two occasions within a 1-week interval. Three different examiners had marked angles on digital pictures. The systematic error and the smallest detectable difference were calculated from the angle values between the image resolutions and times of evaluation. Different resolutions were compared by analysis of variance. Inter- and intra-examiner reliability was calculated by intra-class correlation coefficients (ICC). The rearfoot static angles obtained by the examiners in each resolution were not different (P > 0.05); however, the higher the image resolution the better the inter-examiner reliability. The intra-examiner reliability (within a 1-week interval) was considered to be unacceptable for all image resolutions (ICC range: 0.08-0.52). The whole body image of an adult with a minimum size of 768 pixels analyzed on a 96-ppi screen can provide very good inter-examiner reliability for photogrammetric measurements of rearfoot static angles (ICC range: 0.85-0.92), although the intra-examiner reliability within each resolution was not acceptable. Therefore, this method is not a proper tool for follow-up evaluations of patients within a therapeutic protocol.

In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy.

PubMed

Chen, Sung-Liang; Xie, Zhixing; Carson, Paul L; Wang, Xueding; Guo, L Jay

2011-10-15

We recently proposed photoacoustic correlation spectroscopy (PACS) and demonstrated a proof-of-concept experiment. Here we use the technique for in vivo flow speed measurement in capillaries in a chick embryo model. The photoacoustic microscopy system is used to render high spatial resolution and high sensitivity, enabling sufficient signals from single red blood cells. The probe beam size is calibrated by a blood-mimicking phantom. The results indicate the feasibility of using PACS to study flow speeds in capillaries.

Super-Resolution Imaging of a Dielectric Microsphere Is Governed by the Waist of Its Photonic Nanojet.

PubMed

Yang, Hui; Trouillon, Raphaël; Huszka, Gergely; Gijs, Martin A M

2016-08-10

Dielectric microspheres with appropriate refractive index can image objects with super-resolution, that is, with a precision well beyond the classical diffraction limit. A microsphere is also known to generate upon illumination a photonic nanojet, which is a scattered beam of light with a high-intensity main lobe and very narrow waist. Here, we report a systematic study of the imaging of water-immersed nanostructures by barium titanate glass microspheres of different size. A numerical study of the light propagation through a microsphere points out the light focusing capability of microspheres of different size and the waist of their photonic nanojet. The former correlates to the magnification factor of the virtual images obtained from linear test nanostructures, the biggest magnification being obtained with microspheres of ∼6-7 μm in size. Analyzing the light intensity distribution of microscopy images allows determining analytically the point spread function of the optical system and thereby quantifies its resolution. We find that the super-resolution imaging of a microsphere is dependent on the waist of its photonic nanojet, the best resolution being obtained with a 6 μm Ø microsphere, which generates the nanojet with the minimum waist. This comparison allows elucidating the super-resolution imaging mechanism.

The optical lens coupled X-ray in-line phase contrast imaging system for the characterization of low Z materials

NASA Astrophysics Data System (ADS)

Wang, Kai; Lin, Wei; Dai, Fei; Li, Jun; Qi, Xiaobo; Lei, Haile; Liu, Yuanqiong

2018-05-01

Due to the high spatial resolution and contrast, the optical lens coupled X-ray in-line phase contrast imaging system with the secondary optical magnification is more suitable for the characterization of the low Z materials. The influence of the source to object distance and the object to scintillator distance on the image resolution and contrast is studied experimentally. A phase correlation algorithm is used for the image mosaic of a serial of X-ray phase contrast images acquired with high resolution, the resulting resolution is less than 1.0 μm, and the whole field of view is larger than 1.4 mm. Finally, the geometric morphology and the inner structure of various weakly absorbing samples and the evaporation of water in the plastic micro-shell are in situ characterized by the optical lens coupled X-ray in-line phase contrast imaging system.

Cationic permethylated 6-monoamino-6-monodeoxy-β-cyclodextrin as chiral selector of dansylated amino acids in capillary electrophoresis.

PubMed

Németh, Krisztina; Domonkos, Celesztina; Sarnyai, Virág; Szemán, Julianna; Jicsinszky, László; Szente, Lajos; Visy, Júlia

2014-10-01

The resolution power of permethylated 6-monoamino-6-monodeoxy-βCD (PMMABCD) - a single isomer, cationic CD derivative - developed previously for chiral analyses in capillary electrophoresis was further studied here. Dansylated amino acids (Dns-AA) were chosen as amphoteric chiral model compounds. Changes in the resolutions of Dns-AAs by varying pH and selector concentrations were investigated and correlated with their structures and chemical properties (isoelectric point and lipophilicity). Maximal resolutions could be achieved at pH 6 or pH 4. The separations improved with increasing concentration of the selector. Baseline or substantially better resolution for 8 pairs of these Dns-AAs could be achieved. Low CD concentration was enough for the separation of the most apolar Dns-AAs. Chiral discrimination ability of PMMABCD was demonstrated by the separation of an artificial mixture of 8 Dns-AA pairs. Copyright © 2014 Elsevier B.V. All rights reserved.

Understanding Mn-nodule distribution and evaluation of related deep-sea mining impacts using AUV-based hydroacoustic and optical data

NASA Astrophysics Data System (ADS)

Peukert, Anne; Schoening, Timm; Alevizos, Evangelos; Köser, Kevin; Kwasnitschka, Tom; Greinert, Jens

2018-04-01

In this study, ship- and autonomous underwater vehicle (AUV)-based multibeam data from the German ferromanganese-nodule (Mn-nodule) license area in the Clarion-Clipperton Zone (CCZ; eastern Pacific) are linked to ground-truth data from optical imaging. Photographs obtained by an AUV enable semi-quantitative assessments of nodule coverage at a spatial resolution in the range of meters. Together with high-resolution AUV bathymetry, this revealed a correlation of small-scale terrain variations ( < 5 m horizontally, < 1 m vertically) with nodule coverage. In the presented data set, increased nodule coverage could be correlated with slopes > 1.8° and concave terrain. On a more regional scale, factors such as the geological setting (existence of horst and graben structures, sediment thickness, outcropping basement) and influence of bottom currents seem to play an essential role for the spatial variation of nodule coverage and the related hard substrate habitat. AUV imagery was also successfully employed to map the distribution of resettled sediment following a disturbance and sediment cloud generation during a sampling deployment of an epibenthic sledge. Data from before and after the disturbance allow a direct assessment of the impact. Automated image processing analyzed the nodule coverage at the seafloor, revealing nodule blanketing by resettling of suspended sediment within 16 h after the disturbance. The visually detectable impact was spatially limited to a maximum of 100 m distance from the disturbance track, downstream of the bottom water current. A correlation with high-resolution AUV bathymetry reveals that the blanketing pattern varies in extent by tens of meters, strictly following the bathymetry, even in areas of only slightly undulating seafloor ( < 1 m vertical change). These results highlight the importance of detailed terrain knowledge when engaging in resource assessment studies for nodule abundance estimates and defining mineable areas. At the same time, it shows the importance of high-resolution mapping for detailed benthic habitat studies that show a heterogeneity at scales of 10 to 100 m. Terrain knowledge is also needed to determine the scale of the impact by seafloor sediment blanketing during mining operations.

Conflict resolution abilities in children with Specific Language Impairment.

PubMed

Paula, Erica Macêdo de; Befi-Lopes, Debora Maria

2013-01-01

To investigate the conflict resolution abilities of children with Specific Language Impairment, and to verify whether the time of speech-language therapy correlates to the performance on the conflict resolution task. Participants included 20 children with Specific Language Impairment (Research Group) and 40 children with normal language development (Control Group), with ages ranging from 7 years to 8 years and 11 months. To assess the conflict resolution abilities, five hypothetical contexts of conflict were presented. The strategies used by the children were classified and scored by the following levels: level 0 (solutions that do not match the other levels), level 1 (physical solutions), level 2 (unilateral solutions), level 3 (cooperative solutions), and level 4 (mutual solutions). Statistical analysis showed group effect for the variable total score. There was a difference between the groups for modal development level, with higher level of modal development observed in the Control Group. There was no correlation between the period of speech-language therapy attendance and the total score. Children with Specific Language Impairment present difficulties in solving problems, in view of the fact that they mainly use physical and unilateral strategies. There was no correlation between the time of speech-language therapy and performance in the task.

Environmental, depositional and cultural changes in the upper Pleistocene and early Holocene; the Cinglera del Capello Sequence (Capellades, Spain)

USGS Publications Warehouse

Vaquero, Manuel; Allué, Ethel; Bischoff, James L.; Burjachs, Francesc; Vallverdú, Josep

2013-01-01

The correlation between environmental and cultural changes is one of the primary archeological and paleoanthropological research topics. Analysis of ice and marine cores has yielded a high-resolution record of millennial-scale changes during the Late Pleistocene and Holocene eras. However, cultural changes are documented in low-resolution continental deposits; thus, their correlation with the millennial-scale climatic sequence is often difficult. In this paper, we present a rare occurrence in which a thick archeological sequence is associated with a high-resolution environmental record. The Cinglera del Capello is a tufa-draped cliff located in the northeastern Iberian Peninsula, 50 km west of Barcelona. This cliff harbors several rock-shelters with Late Pleistocene and Early Holocene deposits. Together, the deposits of four rock-shelters span from 7000 to 70,000 years ago and provide a high-resolution record of the environmental and human dynamics during this timespan. This record allows the correlation of the cultural and environmental changes. The multiproxy approach to the Cinglera evidence indicates that the main cultural stages of the Late Pleistocene and Early Holocene (Middle Paleolithic, Upper Paleolithic and Mesolithic) are associated with significant changes in the environmental and depositional contexts.

Recovering the colour-dependent albedo of exoplanets with high-resolution spectroscopy: from ESPRESSO to the ELT.

NASA Astrophysics Data System (ADS)

Martins, J. H. C.; Figueira, P.; Santos, N. C.; Melo, C.; Garcia Muñoz, A.; Faria, J.; Pepe, F.; Lovis, C.

2018-05-01

The characterization of planetary atmospheres is a daunting task, pushing current observing facilities to their limits. The next generation of high-resolution spectrographs mounted on large telescopes - such as ESPRESSO@VLT and HIRES@ELT - will allow us to probe and characterize exoplanetary atmospheres in greater detail than possible to this point. We present a method that permits the recovery of the colour-dependent reflectivity of exoplanets from high-resolution spectroscopic observations. Determining the wavelength-dependent albedo will provide insight into the chemical properties and weather of the exoplanet atmospheres. For this work, we simulated ESPRESSO@VLT and HIRES@ELT high-resolution observations of known planetary systems with several albedo configurations. We demonstrate how the cross correlation technique applied to theses simulated observations can be used to successfully recover the geometric albedo of exoplanets over a range of wavelengths. In all cases, we were able to recover the wavelength dependent albedo of the simulated exoplanets and distinguish between several atmospheric models representing different atmospheric configurations. In brief, we demonstrate that the cross correlation technique allows for the recovery of exoplanetary albedo functions from optical observations with the next generation of high-resolution spectrographs that will be mounted on large telescopes with reasonable exposure times. Its recovery will permit the characterization of exoplanetary atmospheres in terms of composition and dynamics and consolidates the cross correlation technique as a powerful tool for exoplanet characterization.

Observations of the Crab Nebula with the Chandra X-Ray Observatory

NASA Technical Reports Server (NTRS)

Weisskopf, Martin C.

2012-01-01

The Crab Nebula and its pulsar has been the subject of a number of detailed observations with the Chandra X-ray Observatory. The superb angular resolution of Chandra s high-resolution telescope has made possible numerous remarkable results. Here we describe a number of specific studies of the Crab that I and my colleagues have undertaken. We discuss the geometry of the system, which indicates that the "inner X-ray ring", typically identified with the termination shock of the pulsar s particle wind, is most likely not in the equatorial plane of the pulsar. Other topics are the northern wisps and their evolution with time; the characterization of features in the jet to the southeast; pulse-phase spectroscopy and possible correlations with the features at other wavelengths, particularly the optical polarization; and a search for correlations of the X-ray flux with the recently-discovered gamma -ray flares.

A Variable-resolution Surface Wave Dispersion Study of Eurasia, North Africa, and Surrounding Regions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pasyanos, M E

This paper presents the results of a large-scale study of surface wave dispersion performed across Eurasia and North Africa. Improvements were made to previous surface wave work by enlarging the study region, increasing path density, improving spatial resolution, and expanding the period range. This study expands the coverage area northwards and eastwards relative to a previous dispersion analysis, which covered only North Africa and the Middle East. We have significantly increased the number of seismograms examined and group velocity measurements made. We have now made good quality dispersion measurements for about 30,000 Rayleigh wave and 20,000 Love wave paths, andmore » have incorporated measurements from several other researchers into the study. A conjugate gradient method was employed for the group velocity tomography, which improved the inversion from the previous study by adopting a variable smoothness. This technique allows us to go to higher resolution where the data allow without producing artifacts. The current results include both Love and Rayleigh wave inversions across the region for periods from 7 to 100 seconds at 1{sup o} resolution. Short period group velocities are sensitive to slow velocities associated with large sedimentary features such as the Caspian Sea, West Siberian Platform, Mediterranean Sea, Bay of Bengal, Tarim Basin, and Persian Gulf. Intermediate periods are sensitive to differences in crustal thickness, such as those between oceanic and continental crust or along orogenic zones and continental plateaus. At longer periods, fast velocities are consistently found beneath cratons while slow upper mantle velocities occur along rift systems, subduction zones, and collision zones such as the Tethys Belt. We have compared the group velocities at various periods with features such as sediment thickness, topographic height, crustal thickness, proximity to plate boundaries, lithospheric age and lithospheric thickness, and find significant correlations. We don't find any similar correlation between the longest period surface waves and hot spots.« less

Relationships (I) of International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with the ILO International Classification of Radiographs of Pneumoconioses for parenchymal abnormalities.

PubMed

Tamura, Taro; Suganuma, Narufumi; Hering, Kurt G; Vehmas, Tapio; Itoh, Harumi; Akira, Masanori; Takashima, Yoshihiro; Hirano, Harukazu; Kusaka, Yukinori

2015-01-01

The International Classification of High-resolution Computed Tomography (HRCT) for Occupational and Environmental Respiratory Diseases (ICOERD) has been developed for the screening, diagnosis, and epidemiological reporting of respiratory diseases caused by occupational hazards. This study aimed to establish a correlation between readings of HRCT (according to the ICOERD) and those of chest radiography (CXR) pneumoconiotic parenchymal opacities (according to the International Labor Organization Classification/International Classification of Radiographs of Pneumoconioses [ILO/ICRP]). Forty-six patients with and 28 controls without mineral dust exposure underwent posterior-anterior CXR and HRCT. We recorded all subjects' exposure and smoking history. Experts independently read CXRs (using ILO/ICRP). Experts independently assessed HRCT using the ICOERD parenchymal abnormalities grades for well-defined rounded opacities (RO), linear and/or irregular opacities (IR), and emphysema (EM). The correlation between the ICOERD summed grades and ILO/ICRP profusions was evaluated using Spearman's rank-order correlation. Twenty-three patients had small opacities on CXR. HRCT showed that 21 patients had RO; 20 patients, IR opacities; and 23 patients, EM. The correlation between ILO/ICRP profusions and the ICOERD grades was 0.844 for rounded opacities (p<0.01). ICOERD readings from HRCT scans correlated well with previously validated ILO/ICRP criteria. The ICOERD adequately detects pneumoconiotic micronodules and can be used for the interpretation of pneumoconiosis.

[Combined use of ECK-triggered 2D-phase contrast MR angiography and 2D-time-of-flight MR angiography for planning and follow up before and after vascular intervention of pelvic and leg arteries].

PubMed

Reimer, P; Wilhelm, M; Lentschig, M; Wörtler, K; Marx, C; Allkemper, T; Boettger, U; Heinecke, A; Rummeny, E J; Peters, P E

1998-03-01

To develop a strategy for the complete work-up of vessel lumen and vessel wall for planning and follow-up of radiological interventions of lower extremity arteries. A total of 36 patients (21 pre-, 8 post- and 7 pre- and postinterventional) were studied. MRA studies were performed using an ECG-triggered phase contrast technique for the demonstration of intraluminal flow and an axial high resolution time-of-flight technique to assess the vascular wall. All MRA studies were analysed by intraindividual DSA comparison for the assessment of flow and wall structures. Combined MRA techniques provided a good correlation with DSA for the assessment of vascular flow. The kappa test revealed a value of greater than 0.61 for most on the vessel segments proving a good correlation of both methods. Orthogonal high-resolution TOF-MRA provided additional information for the assessment postinterventional wall haematomas and hard plaques. Combination of PCA to study flow and axial TOF to study wall pathology improves the usefulness of peripheral MRA.

Fourth-Order Spatial Correlation of Thermal Light

NASA Astrophysics Data System (ADS)

Wen, Feng; Zhang, Xun; Xue, Xin-Xin; Sun, Jia; Song, Jian-Ping; Zhang, Yan-Peng

2014-11-01

We investigate the fourth-order spatial correlation properties of pseudo-thermal light in the photon counting regime, and apply the Klyshko advanced-wave picture to describe the process of four-photon coincidence counting measurement. We deduce the theory of a proof-of-principle four-photon coincidence counting configuration, and find that if the four randomly radiated photons come from the same radiation area and are indistinguishable in principle, the fourth-order correlation of them is 24 times larger than that when four photons come from different radiation areas. In addition, we also show that the higher-order spatial correlation function can be decomposed into multiple lower-order correlation functions, and the contrast and visibility of low-order correlation peaks are less than those of higher orders, while the resolutions all are identical. This study may be useful for better understanding the four-photon interference and multi-channel correlation imaging.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Timmermans, F. J.; Otto, C.

New developments in the field of microscopy enable to acquire increasing amounts of information from large sample areas and at an increased resolution. Depending on the nature of the technique, the information may reveal morphological, structural, chemical, and still other sample characteristics. In research fields, such as cell biology and materials science, there is an increasing demand to correlate these individual levels of information and in this way to obtain a better understanding of sample preparation and specific sample properties. To address this need, integrated systems were developed that combine nanometer resolution electron microscopes with optical microscopes, which produce chemicallymore » or label specific information through spectroscopy. The complementary information from electron microscopy and light microscopy presents an opportunity to investigate a broad range of sample properties in a correlated fashion. An important part of correlating the differences in information lies in bridging the different resolution and image contrast features. The trend to analyse samples using multiple correlated microscopes has resulted in a new research field. Current research is focused, for instance, on (a) the investigation of samples with nanometer scale distribution of inorganic and organic materials, (b) live cell analysis combined with electron microscopy, and (c) in situ spectroscopic and electron microscopy analysis of catalytic materials, but more areas will benefit from integrated correlative microscopy.« less

Correlative Fluorescence and Electron Microscopy in 3D-Scanning Electron Microscope Perspective.

PubMed

Franks, Jonathan; Wallace, Callen T; Shibata, Masateru; Suga, Mitsuo; Erdman, Natasha; Stolz, Donna B; Watkins, Simon C

2017-04-03

The ability to correlate fluorescence microscopy (FM) and electron microscopy (EM) data obtained on biological (cell and tissue) specimens is essential to bridge the resolution gap between the data obtained by these different imaging techniques. In the past such correlations were limited to either EM navigation in two dimensions to the locations previously highlighted by fluorescence markers, or subsequent high-resolution acquisition of tomographic information using a TEM. We present a novel approach whereby a sample previously investigated by FM is embedded and subjected to sequential mechanical polishing and backscatter imaging by scanning electron microscope. The resulting three dimensional EM tomogram of the sample can be directly correlated to the FM data. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

High-resolution magnetic resonance imaging of carotid atherosclerotic plaques - a correlation study with histopathology.

PubMed

Xia, Zhangyong; Yang, Hua; Yuan, Xiaochun; Wang, Jiyue; Zhang, Shigang; Zhang, Liyong; Qu, Yang; Chen, Jun; Jiao, Liqun; Wang, Le-Xin; Du, Yifeng

2017-07-01

This study aimed to utilize high-resolution magnetic resonance imaging (MRI) to investigate the characteristics of stable and vulnerable carotid arteriosclerotic plaques, with correlations to histopathological findings. High-resolution MRI was performed in 817 patients, using three-dimensional magnetic resonance angiography. Plaque composition was evaluated by measuring the areas occupied by calcification, a lipid-rich necrotic core, intra-plaque haemorrhage, and fibrous cap rupture. Plaque morphology was analysed by measuring vessel wall area, thickness, and luminal area at the bifurcation of the common carotid artery. Plaque tissues were sampled during carotid endarterectomy and examined using haematoxylin-eosin, Oil Red O, Masson trichrome staining, and immunohistochemical staining for CD68. Patients were divided into stable plaque group (n = 462) and vulnerable plaque group (n = 355), based on intraoperative observations and postoperative histopathological findings. Compared to the stable plaque group, the vulnerable plaque group exhibited increased vessel wall areas and thickness, and decreased mean luminal areas (P < 0.001). The vulnerable plaque group also had a lower collagen content, a higher lipid content, and higher CD68 expression in plaque tissues on histological examinations (P < 0.01). Incidences of lipid-rich necrotic core (38.1 % vs. 34.3 %), intra-plaque haemorrhage (26.9 % vs. 22.8 %), plaque calcification (45.2 % vs. 40.9 %), and fibrous cap rupture (36.0 % vs 39.8 %) in the plaques were concordant with MRI observations and histopathological findings (p > 0.05). Stable and vulnerable carotid plaques had different morphologies and compositions. High-resolution MRI can assess such differences qualitatively and quantitatively in vivo and provide guidance for risk stratification and management.

Neural correlates of distraction and conflict resolution for nonverbal auditory events.

PubMed

Stewart, Hannah J; Amitay, Sygal; Alain, Claude

2017-05-09

In everyday situations auditory selective attention requires listeners to suppress task-irrelevant stimuli and to resolve conflicting information in order to make appropriate goal-directed decisions. Traditionally, these two processes (i.e. distractor suppression and conflict resolution) have been studied separately. In the present study we measured neuroelectric activity while participants performed a new paradigm in which both processes are quantified. In separate block of trials, participants indicate whether two sequential tones share the same pitch or location depending on the block's instruction. For the distraction measure, a positive component peaking at ~250 ms was found - a distraction positivity. Brain electrical source analysis of this component suggests different generators when listeners attended to frequency and location, with the distraction by location more posterior than the distraction by frequency, providing support for the dual-pathway theory. For the conflict resolution measure, a negative frontocentral component (270-450 ms) was found, which showed similarities with that of prior studies on auditory and visual conflict resolution tasks. The timing and distribution are consistent with two distinct neural processes with suppression of task-irrelevant information occurring before conflict resolution. This new paradigm may prove useful in clinical populations to assess impairments in filtering out task-irrelevant information and/or resolving conflicting information.

Improving the City-scale Emission Inventory of Anthropogenic Air Pollutants: A Case Study of Nanjing

NASA Astrophysics Data System (ADS)

Qiu, L.; Zhao, Y.; Xu, R.; Xie, F.; Wang, H.; Qin, H.; Wu, X.; Zhang, J.

2014-12-01

To evaluate the improvement of city-scale emission inventory, a high-resolution emission inventory of air pollutants for Nanjing is first developed combining detailed source information, and then justified through quantitative analysis with observations. The best available domestic emission factors and unit-/facility-based activity level data were compiled based on a thorough field survey on major emission sources. Totally 1089 individual emission sources were identified as point sources and all the emission-related parameters including burner type, combustion technology, fuel quality, and removal efficiency of pollution control devices, are carefully investigated and analyzed. Some new data such as detailed information of city fueling-gas stations, construction sites, monthly activity level, data from continuous emission monitoring systems and traffic flow information were combined to improve spatiotemporal distribution of this inventory. For SO2, NOX and CO, good spatial correlations were found between ground observation (9 state controlling air sampling sites in Nanjing) and city-scale emission inventory (R2=0.34, 0.38 and 0.74, respectively). For TSP, PM10 and PM2.5, however, poorer correlation was found due to relatively weaker accuracy in emission estimation and spatial distribution of road dust. The mixing ratios between specific pollutants including OC/EC, BC/CO and CO2/CO, are well correlated between those from ground observation and emission. Compared to MEIC (Multi-resolution Emission Inventory for China), there is a better spatial consistence between this city-scale emission inventory and NO2 measured by OMI (Ozone Monitoring Instrument). In particular, the city-scale emission inventory still correlated well with satellite observations (R2=0.28) while the regional emission inventory showed little correlation with satellite observations (R2=0.09) when grids containing power plants are excluded. It thus confirms the improvement of city-scale emission inventory on industrial and transportation sources other than big power plants. Through the inventory evaluation, the necessity to develop high-resolution emission inventory with comprehensive emission source information is revealed for atmospheric science studies and air quality improvement at local scale.

Using multi-scale sampling and spatial cross-correlation to investigate patterns of plant species richness

USGS Publications Warehouse

Kalkhan, M.A.; Stohlgren, T.J.

2000-01-01

Land managers need better techniques to assess exoticplant invasions. We used the cross-correlationstatistic, IYZ, to test for the presence ofspatial cross-correlation between pair-wisecombinations of soil characteristics, topographicvariables, plant species richness, and cover ofvascular plants in a 754 ha study site in RockyMountain National Park, Colorado, U.S.A. Using 25 largeplots (1000 m2) in five vegetation types, 8 of 12variables showed significant spatial cross-correlationwith at least one other variable, while 6 of 12variables showed significant spatial auto-correlation. Elevation and slope showed significant spatialcross-correlation with all variables except percentcover of native and exotic species. Percent cover ofnative species had significant spatialcross-correlations with soil variables, but not withexotic species. This was probably because of thepatchy distributions of vegetation types in the studyarea. At a finer resolution, using data from ten1 m2 subplots within each of the 1000 m2 plots, allvariables showed significant spatial auto- andcross-correlation. Large-plot sampling was moreaffected by topographic factors than speciesdistribution patterns, while with finer resolutionsampling, the opposite was true. However, thestatistically and biologically significant spatialcorrelation of native and exotic species could only bedetected with finer resolution sampling. We foundexotic plant species invading areas with high nativeplant richness and cover, and in fertile soils high innitrogen, silt, and clay. Spatial auto- andcross-correlation statistics, along with theintegration of remotely sensed data and geographicinformation systems, are powerful new tools forevaluating the patterns and distribution of native andexotic plant species in relation to landscape structure.

A challenge for probing the statistics of interstellar magnetic fields: beyond the Planck resolution with Herschel

NASA Astrophysics Data System (ADS)

Bracco, Andrea; André, Philippe; Boulanger, Francois

2015-08-01

The recent Planck results in polarization at sub-mm wavelengths allow us to gain insight into the Galactic magnetic field topology, revealing its statistical correlation with matter, from the diffuse interstellar medium (ISM), to molecular clouds (MCs) (Planck intermediate results. XXXII, XXXIII, XXXV). This correlation has a lot to tell us about the dynamics of the turbulent ISM, stressing the importance of considering magnetic fields in the formation of structures, some of which eventually undergo gravitational collapse producing new star-forming cores.Investigating the early phases of star formation has been a fundamental scope of the Herschel Gould Belt survey collaboration (http://gouldbelt-herschel.cea.fr), which, in the last years, has thoroughly characterized, at a resolution of few tens of arcseconds, the statistics of MCs, such as their filamentary structure, kinematics and column density.Although at lower angular resolution, the Planck maps of dust emission at 353GHz, in intensity and polarization, show that all MCs are complex environments, where we observe a non-trivial correlation between the magnetic field and their density structure. This result opens new perspectives on their formation and evolution, which we have started to explore.In this talk, I will present first results of a comparative analysis of the Herschel-Planck data, where we combine the high resolution Herschel maps of some MCs of the Gould Belt with the Planck polarization data, which sample the structure of the field weighted by the density.In particular, I will discuss the large-scale envelopes of the selected MCs, and, given the correlation between magnetic field and matter, I will show how to make use of the high resolution information of the density structure provided by Herschel to investigate the statistics of interstellar magnetic fields in the Planck data.

Quantitative comparison of high-resolution MRI and myelin-stained histology of the human cerebral cortex.

PubMed

Osechinskiy, Sergey; Kruggel, Frithjof

2009-01-01

The architectonic analysis of the human cerebral cortex is presently based on the examination of stained tissue sections. Recent progress in high-resolution magnetic resonance imaging (MRI) promotes the feasibility of an in vivo architectonic analysis. Since the exact relationship between the laminar fine-structure of a cortical MRI signal and histological cyto-and myeloarchitectonic staining patterns is not known, a quantitative study comparing high-resolution MRI to histological ground truth images is necessary for validating a future MRI based architectonic analysis. This communication describes an ongoing study comparing post mortem MR images to a myelin-stained histology of the brain cortex. After establishing a close spatial correspondence between histological sections and MRI using a slice-to-volume nonrigid registration algorithm, transcortical intensity profiles, extracted from both imaging modalities along curved trajectories of a Laplacian vector field, are compared via a cross-correlational analysis.

Neural and Behavioral Correlates of Song Prosody

ERIC Educational Resources Information Center

Gordon, Reyna Leigh

2010-01-01

This dissertation studies the neural basis of song, a universal human behavior. The relationship of words and melodies in the perception of song at phonological, semantic, melodic, and rhythmic levels of processing was investigated using the fine temporal resolution of Electroencephalography (EEG). The observations reported here may shed light on…

Weak data do not make a free lunch, only a cheap meal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Zhipu; Rajashankar, Kanagalaghatta; Dauter, Zbigniew

2014-01-17

Four data sets were processed at resolutions significantly exceeding the criteria traditionally used for estimating the diffraction data resolution limit. The analysis of these data and the corresponding model-quality indicators suggests that the criteria of resolution limits widely adopted in the past may be somewhat conservative. Various parameters, such asR mergeandI/σ(I), optical resolution and the correlation coefficients CC 1/2and CC*, can be used for judging the internal data quality, whereas the reliability factorsRandR freeas well as the maximum-likelihood target values and real-space map correlation coefficients can be used to estimate the agreement between the data and the refined model. However,more » none of these criteria provide a reliable estimate of the data resolution cutoff limit. The analysis suggests that extension of the maximum resolution by about 0.2 Å beyond the currently adopted limit where theI/σ(I) value drops to 2.0 does not degrade the quality of the refined structural models, but may sometimes be advantageous. Such an extension may be particularly beneficial for significantly anisotropic diffraction. Extension of the maximum resolution at the stage of data collection and structure refinement is cheap in terms of the required effort and is definitely more advisable than accepting a too conservative resolution cutoff, which is unfortunately quite frequent among the crystal structures deposited in the Protein Data Bank.« less

Ultrahigh-Resolution Magnetic Resonance in Inhomogeneous Magnetic Fields: Two-Dimensional Long-Lived-Coherence Correlation Spectroscopy

NASA Astrophysics Data System (ADS)

Chinthalapalli, Srinivas; Bornet, Aurélien; Segawa, Takuya F.; Sarkar, Riddhiman; Jannin, Sami; Bodenhausen, Geoffrey

2012-07-01

A half-century quest for improving resolution in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) has enabled the study of molecular structures, biological interactions, and fine details of anatomy. This progress largely relied on the advent of sophisticated superconducting magnets that can provide stable and homogeneous fields with temporal and spatial variations below ΔB0/B0<0.01ppm. In many cases however, inherent properties of the objects under investigation, pulsating arteries, breathing lungs, tissue-air interfaces, surgical implants, etc., lead to fluctuations and losses of local homogeneity. A new method dubbed “long-lived-coherence correlation spectroscopy” (LLC-COSY) opens the way to overcome both inhomogeneous and homogeneous broadening, which arise from local variations in static fields and fluctuating dipole-dipole interactions, respectively. LLC-COSY makes it possible to obtain ultrahigh resolution two-dimensional spectra, with linewidths on the order of Δν=0.1 to 1 Hz, even in very inhomogeneous fields (ΔB0/B0>10ppm or 5000 Hz at 9.7 T), and can improve resolution by a factor up to 9 when the homogeneous linewidths are determined by dipole-dipole interactions. The resulting LLC-COSY spectra display chemical shift differences and scalar couplings in two orthogonal dimensions, like in “J spectroscopy.” LLC-COSY does not require any sophisticated gradient switching or frequency-modulated pulses. Applications to in-cell NMR and to magnetic resonance spectroscopy (MRS) of selected volume elements in MRI appear promising, particularly when susceptibility variations tend to preclude high resolution.

Phenology and climate relationships in aspen (Populus tremuloides Michx.) forest and woodland communities of southwestern Colorado

USGS Publications Warehouse

Meier, Gretchen A.; Brown, Jesslyn F.; Evelsizer, Ross J.; Vogelmann, James E.

2014-01-01

Trembling aspen (Populus tremuloides Michx.) occurs over wide geographical, latitudinal, elevational, and environmental gradients, making it a favorable candidate for a study of phenology and climate relationships. Aspen forests and woodlands provide numerous ecosystem services, such as high primary productivity and biodiversity, retention and storage of environmental variables (precipitation, temperature, snow–water equivalent) that affect the spring and fall phenology of the aspen woodland communities of southwestern Colorado. We assessed the land surface phenology of aspen woodlands using two phenology indices, start of season time (SOST) and end of season time (EOST), from the U.S. Geological Survey (USGS) database of conterminous U.S. phenological indicators over an 11-year time period (2001–2011). These indicators were developed with 250 m resolution remotely sensed data from the Moderate Resolution Imaging Spectroradiometer processed to highlight vegetation response. We compiled data on SOST, EOST, elevation, precipitation, air temperature, and snow water equivalent (SWE) for selected sites having more than 80% cover by aspen woodland communities. In the 11-year time frame of our study, EOST had significant positive correlation with minimum fall temperature and significant negative correlation with fall precipitation. SOST had a significant positive correlation with spring SWE and spring maximum temperature.

Ocean color remote sensing of turbid plumes in the southern California coastal waters during storm events

NASA Astrophysics Data System (ADS)

Lahet, Florence; Stramski, Dariusz

2007-09-01

Water-leaving radiance data obtained from MODIS-Aqua satellite images at spatial resolution of 250 m (band 1 at 645 nm) and 500 m (band 4 at 555 nm) were used to analyze the correlation between plume area and rainfall during strong storm events in coastal waters of Southern California. Our study is focused on the area between Point Loma and the US-Mexican border in San Diego, which is influenced by terrigenous input of particulate and dissolved materials from San Diego and Tijuana watersheds and non-point sources along the shore. For several events of intense rainstorms that occurred in the winter of 2004-2005, we carried out a correlational analysis between the satellite-derived plume area and rainfall parameters. We examined several rainfall parameters and methods for the estimation of plume area. We identified the optimal threshold values of satellite-derived normalized water-leaving radiances at 645 nm and 555 nm for distinguishing the plume from ambient ocean waters. The satellite-derived plume size showed high correlation with the amount of precipitated water accumulated during storm event over the San Diego and Tijuana watersheds. Our results support the potential of ocean color imagery with relatively high spatial resolution for the study of turbid plumes in the coastal ocean.

Engineering solar cells based on correlative X-ray microscopy

DOE PAGES

Stuckelberger, Michael; West, Bradley; Nietzold, Tara; ...

2017-05-01

In situ and operando measurement techniques combined with nanoscale resolution have proven invaluable in multiple fields of study. We argue that evaluating device performance as well as material behavior by correlative X-ray microscopy with <100 nm resolution can radically change the approach for optimizing absorbers, interfaces and full devices in solar cell research. Here, we thoroughly discuss the measurement technique of X-ray beam induced current and point out fundamental differences between measurements of wafer-based silicon and thin-film solar cells. Based on reports of the last years, we showcase the potential that X-ray microscopy measurements have in combination with in situmore » and operando approaches throughout the solar cell lifecycle: from the growth of individual layers to the performance under operating conditions and degradation mechanisms. Enabled by new developments in synchrotron beamlines, the combination of high spatial resolution with high brilliance and a safe working distance allows for the insertion of measurement equipment that can pave the way for a new class of experiments. When applied to photovoltaics research, we highlight today’s opportunities and challenges in the field of nanoscale X-ray microscopy, and give an outlook on future developments.« less

Generating daily high spatial land surface temperatures by combining ASTER and MODIS land surface temperature products for environmental process monitoring.

PubMed

Wu, Mingquan; Li, Hua; Huang, Wenjiang; Niu, Zheng; Wang, Changyao

2015-08-01

There is a shortage of daily high spatial land surface temperature (LST) data for use in high spatial and temporal resolution environmental process monitoring. To address this shortage, this work used the Spatial and Temporal Adaptive Reflectance Fusion Model (STARFM), Enhanced Spatial and Temporal Adaptive Reflectance Fusion Model (ESTARFM), and the Spatial and Temporal Data Fusion Approach (STDFA) to estimate high spatial and temporal resolution LST by combining Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) LST and Moderate Resolution Imaging Spectroradiometer (MODIS) LST products. The actual ASTER LST products were used to evaluate the precision of the combined LST images using the correlation analysis method. This method was tested and validated in study areas located in Gansu Province, China. The results show that all the models can generate daily synthetic LST image with a high correlation coefficient (r) of 0.92 between the synthetic image and the actual ASTER LST observations. The ESTARFM has the best performance, followed by the STDFA and the STARFM. Those models had better performance in desert areas than in cropland. The STDFA had better noise immunity than the other two models.

Development of a Values Conflict Resolution Assessment.

ERIC Educational Resources Information Center

Kinnier, Richard T.

1987-01-01

Describes the development of a Values Conflict Resolution Assessment (VCRA) and reports on validation and reliability. Items were constructed from theoretical criteria in values clarification and decision making with "ethical-emotional" and "rational-behavioral" components. VCRA scores correlated negatively with…

Automated vessel segmentation using cross-correlation and pooled covariance matrix analysis.

PubMed

Du, Jiang; Karimi, Afshin; Wu, Yijing; Korosec, Frank R; Grist, Thomas M; Mistretta, Charles A

2011-04-01

Time-resolved contrast-enhanced magnetic resonance angiography (CE-MRA) provides contrast dynamics in the vasculature and allows vessel segmentation based on temporal correlation analysis. Here we present an automated vessel segmentation algorithm including automated generation of regions of interest (ROIs), cross-correlation and pooled sample covariance matrix analysis. The dynamic images are divided into multiple equal-sized regions. In each region, ROIs for artery, vein and background are generated using an iterative thresholding algorithm based on the contrast arrival time map and contrast enhancement map. Region-specific multi-feature cross-correlation analysis and pooled covariance matrix analysis are performed to calculate the Mahalanobis distances (MDs), which are used to automatically separate arteries from veins. This segmentation algorithm is applied to a dual-phase dynamic imaging acquisition scheme where low-resolution time-resolved images are acquired during the dynamic phase followed by high-frequency data acquisition at the steady-state phase. The segmented low-resolution arterial and venous images are then combined with the high-frequency data in k-space and inverse Fourier transformed to form the final segmented arterial and venous images. Results from volunteer and patient studies demonstrate the advantages of this automated vessel segmentation and dual phase data acquisition technique. Copyright © 2011 Elsevier Inc. All rights reserved.

Crackle analysis for chest auscultation and comparison with high-resolution CT findings.

PubMed

Kawamura, Takeo; Matsumoto, Tsuneo; Tanaka, Nobuyuki; Kido, Shoji; Jiang, Zhongwei; Matsunaga, Naofumi

2003-01-01

The purpose of our study was to clarify the correlation between respiratory sounds and the high-resolution CT (HRCT) findings of lung diseases. Respiratory sounds were recorded using a stethoscope in 41 patients with crackles. All had undergone inspiratory and expiratory CT. Subjects included 18 patients with interstitial pneumonia and 23 without interstitial pneumonia. Two parameters, two-cycle duration (2CD) and initial deflection width (IDW) of the "crackle," were induced by time-expanded waveform analysis. Two radiologists independently assessed 11 HRCT findings. An evaluation was carried out to determine whether there was a significant difference in the two parameters between the presence and absence of each HRCT finding. The two parameters of crackles were significantly shorter in the interstitial pneumonia group than the non-interstitial pneumonia group. Ground-glass opacity, honeycombing, lung volume reduction, traction bronchiectasis, centrilobular nodules, emphysematous change, and attenuation and volume change between inspiratory and expiratory CT were correlated with one or two parameters in all patients, whereas the other three findings were not. Among the interstitial pneumonia group, traction bronchiectasis, emphysematous change, and attenuation and volume change between inspiratory and expiratory CT were significantly correlated with one or two parameters. Abnormal respiratory sounds were correlated with some HRCT findings.

Computed tomography in pulmonary sarcoidosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynch, D.A.; Webb, W.R.; Gamsu, G.

1989-05-01

We studied the high resolution CT (HRCT) scans of 15 patients with biopsy-proven sarcoidosis and correlated the findings with pulmonary function tests (12 patients), 67Ga scans (10 patients), bronchoalveolar lavage (five patients), recent transbronchial biopsy (six patients), and recent open lung biopsy (three patients). The HRCT features included small nodules, thickened interlobular septa, patchy focal increase in lung density, honeycombing, and central conglomeration of vessels and bronchi. Active alveolitis was present by gallium scanning criteria in 5 of 10 cases. By bronchoalveolar lavage criteria, activity was present in three of five cases. Patchy increase in density may correlate with activemore » alveolitis as seen on /sup 67/Ga scanning. High resolution CT was better than chest X-radiography for demonstration of patchy increase in density and for distinguishing nodules from septal thickening. Both nodules and patchy density were partly reversible following therapy. Nodular densities seen on CT correlated with the presence of granulomata on histology. Resting pulmonary function tests correlated poorly with presence and extent of lung disease on HRCT. The presence on HRCT of focal fine nodules, patchy focal increase in lung density, and central crowding of bronchi and vessels should suggest the diagnosis of sarcoidosis. In some patients, HRCT can identify unsuspected parenchymal lung disease and document the reversible components of sarcoid lung disease.« less

Vernier-like super resolution with guided correlated photon pairs.

PubMed

Nespoli, Matteo; Goan, Hsi-Sheng; Shih, Min-Hsiung

2016-01-11

We describe a dispersion-enabled, ultra-low power realization of super-resolution in an integrated Mach-Zehnder interferometer. Our scheme is based on a Vernier-like effect in the coincident detection of frequency correlated, non-degenerate photon pairs at the sensor output in the presence of group index dispersion. We design and simulate a realistic integrated refractive index sensor in a silicon nitride on silica platform and characterize its performance in the proposed scheme. We present numerical results showing a sensitivity improvement upward of 40 times over a traditional sensing scheme. The device we design is well within the reach of modern semiconductor fabrication technology. We believe this is the first metrology scheme that uses waveguide group index dispersion as a resource to attain super-resolution.

Detector Development for the abBA Experiment.

PubMed

Seo, P-N; Bowman, J D; Mitchell, G S; Penttila, S I; Wilburn, W S

2005-01-01

We have developed a new type of field-expansion spectrometer to measure the neutron beta decay correlations (a, b, B, and A). A precision measurement of these correlations places stringent requirements on charged particle detectors. The design employs large area segmented silicon detectors to detect both protons and electrons in coincidence. Other requirements include good energy resolution (< 5 keV), a thin dead layer to allow observation of 30-keV protons, fast timing resolution (~1 ns) to reconstruct electron-backscattering events, and nearly unity efficiency. We report results of testing commercially available surface-barrier silicon detectors for energy resolution and timing performance, and measurement of the dead-layer thickness of ion-implanted silicon detectors with a 3.2 MeV alpha source.

Coherent manipulation of spin correlations in the Hubbard model

NASA Astrophysics Data System (ADS)

Wurz, N.; Chan, C. F.; Gall, M.; Drewes, J. H.; Cocchi, E.; Miller, L. A.; Pertot, D.; Brennecke, F.; Köhl, M.

2018-05-01

We coherently manipulate spin correlations in a two-component atomic Fermi gas loaded into an optical lattice using spatially and time-resolved Ramsey spectroscopy combined with high-resolution in situ imaging. This technique allows us not only to imprint spin patterns but also to probe the static magnetic structure factor at an arbitrary wave vector, in particular, the staggered structure factor. From a measurement along the diagonal of the first Brillouin zone of the optical lattice, we determine the magnetic correlation length and the individual spatial spin correlators. At half filling, the staggered magnetic structure factor serves as a sensitive thermometer, which we employ to study the equilibration in the spin and density sector during a slow quench of the lattice depth.

Measuring Long-Range 13C– 13C Correlations on a Surface under Natural Abundance Using Dynamic Nuclear Polarization-Enhanced Solid-State Nuclear Magnetic Resonance [Measuring Long Range 13C– 13C Correlations on Surface under Natural Abundance Using DNP-enhanced Solid-state NMR

DOE PAGES

Kobayashi, Takeshi; Slowing, Igor I.; Pruski, Marek

2017-10-13

Here, we report that spatial (<1 nm) proximity between different molecules in solid bulk materials and, for the first time, different moieties on the surface of a catalyst, can be established without isotope enrichment by means of homonuclear CHHC solid-state nuclear magnetic resonance experiment. This 13C– 13C correlation measurement, which hitherto was not possible for natural-abundance solids, was enabled by the use of dynamic nuclear polarization. Importantly, it allows the study of long-range correlations in a variety of materials with high resolution.

Measuring Long-Range 13C– 13C Correlations on a Surface under Natural Abundance Using Dynamic Nuclear Polarization-Enhanced Solid-State Nuclear Magnetic Resonance [Measuring Long Range 13C– 13C Correlations on Surface under Natural Abundance Using DNP-enhanced Solid-state NMR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kobayashi, Takeshi; Slowing, Igor I.; Pruski, Marek

Here, we report that spatial (<1 nm) proximity between different molecules in solid bulk materials and, for the first time, different moieties on the surface of a catalyst, can be established without isotope enrichment by means of homonuclear CHHC solid-state nuclear magnetic resonance experiment. This 13C– 13C correlation measurement, which hitherto was not possible for natural-abundance solids, was enabled by the use of dynamic nuclear polarization. Importantly, it allows the study of long-range correlations in a variety of materials with high resolution.

Spatiotemporal image correlation analysis of blood flow in branched vessel networks of zebrafish embryos

NASA Astrophysics Data System (ADS)

Ceffa, Nicolo G.; Cesana, Ilaria; Collini, Maddalena; D'Alfonso, Laura; Carra, Silvia; Cotelli, Franco; Sironi, Laura; Chirico, Giuseppe

2017-10-01

Ramification of blood circulation is relevant in a number of physiological and pathological conditions. The oxygen exchange occurs largely in the capillary bed, and the cancer progression is closely linked to the angiogenesis around the tumor mass. Optical microscopy has made impressive improvements in in vivo imaging and dynamic studies based on correlation analysis of time stacks of images. Here, we develop and test advanced methods that allow mapping the flow fields in branched vessel networks at the resolution of 10 to 20 μm. The methods, based on the application of spatiotemporal image correlation spectroscopy and its extension to cross-correlation analysis, are applied here to the case of early stage embryos of zebrafish.

Love and the commitment problem in romantic relations and friendship.

PubMed

Gonzaga, G C; Keltner, D; Londahl, E A; Smith, M D

2001-08-01

On the basis of the proposition that love promotes commitment, the authors predicted that love would motivate approach, have a distinct signal, and correlate with commitment-enhancing processes when relationships are threatened. The authors studied romantic partners and adolescent opposite-sex friends during interactions that elicited love and threatened the bond. As expected, the experience of love correlated with approach-related states (desire, sympathy). Providing evidence for a nonverbal display of love, four affiliation cues (head nods, Duchenne smiles, gesticulation, forward leans) correlated with self-reports and partner estimates of love. Finally, the experience and display of love correlated with commitment-enhancing processes (e.g., constructive conflict resolution, perceived trust) when the relationship was threatened. Discussion focused on love, positive emotion, and relationships.

Randomized controlled trial of benzocaine versus placebo spray for pain relief at hysterosalpingogram.

PubMed

Bachman, E A; Senapati, S; Sammel, M D; Kalra, S K

2014-06-01

Many women experience pain during hysterosalpingogram (HSG). This prospective, randomized, double-blinded, placebo-controlled study assessed whether the use of benzocaine spray during HSG is associated with reduced pain as compared with placebo. Thirty women presenting for HSG were enrolled and randomized to either benzocaine or saline spray. Treatment groups were similar in age, race, parity, pre-procedure oral analgesic use and history of dysmenorrhoea and/or chronic pelvic pain. Median change in pain score from baseline to procedure was 50.6mm (-7.4 to 98.8mm) in the benzocaine group and 70.4mm (19.8 to 100mm) in the placebo group. There was no difference between groups after adjusting for history of dysmenorrhoea. There was no difference in resolution of pain in benzocaine versus placebo groups at 5 min post procedure--median pain score difference -11.1 (-90.1 to 18.5) versus -37.0 (-100 to 1.2)--or at 30 min post procedure. Satisfaction scores did not differ by treatment and did not correlate with pain score during the procedure (rho=0.005). The use of benzocaine spray does not significantly improve pain relief during HSG nor does it hasten resolution of pain post HSG. Of interest, patient satisfaction was not correlated with pain. Many women experience pain during hysterosalpingogram (HSG), which is a test used to evaluate the uterine cavity and fallopian tube. We conducted a prospective, randomized, double-blinded, placebo-controlled study to assess whether the use of benzocaine spray during HSG is associated with reduced pain as compared with placebo. Thirty women presenting for HSG were enrolled and randomized to either benzocaine or saline spray. Treatment groups were similar in age, race, previous pregnancies, pre-procedure oral analgesic use and history of dysmenorrhoea (painful periods) and/or chronic pelvic pain. There was no difference in pain scores or resolution of pain between the two groups. Satisfaction scores did not differ by treatment group and did not correlate with the pain score during the procedure. We conclude that the use of benzocaine spray does not significantly improve pain relief during HSG nor does it hasten resolution of pain post HSG. Of interest, patient satisfaction was not correlated with pain. Copyright © 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

High resolution NMR study of T{sub 1} magnetic relaxation dispersion. IV. Proton relaxation in amino acids and Met-enkephalin pentapeptide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pravdivtsev, Andrey N.; Yurkovskaya, Alexandra V.; Ivanov, Konstantin L., E-mail: ivanov@tomo.nsc.ru

2014-10-21

Nuclear Magnetic Relaxation Dispersion (NMRD) of protons was studied in the pentapeptide Met-enkephalin and the amino acids, which constitute it. Experiments were run by using high-resolution Nuclear Magnetic Resonance (NMR) in combination with fast field-cycling, thus enabling measuring NMRD curves for all individual protons. As in earlier works, Papers I–III, pronounced effects of intramolecular scalar spin-spin interactions, J-couplings, on spin relaxation were found. Notably, at low fields J-couplings tend to equalize the apparent relaxation rates within networks of coupled protons. In Met-enkephalin, in contrast to the free amino acids, there is a sharp increase in the proton T{sub 1}-relaxation timesmore » at high fields due to the changes in the regime of molecular motion. The experimental data are in good agreement with theory. From modelling the relaxation experiments we were able to determine motional correlation times of different residues in Met-enkephalin with atomic resolution. This allows us to draw conclusions about preferential conformation of the pentapeptide in solution, which is also in agreement with data from two-dimensional NMR experiments (rotating frame Overhauser effect spectroscopy). Altogether, our study demonstrates that high-resolution NMR studies of magnetic field-dependent relaxation allow one to probe molecular mobility in biomolecules with atomic resolution.« less

Multispectral image sharpening using a shift-invariant wavelet transform and adaptive processing of multiresolution edges

USGS Publications Warehouse

Lemeshewsky, G.P.; Rahman, Z.-U.; Schowengerdt, R.A.; Reichenbach, S.E.

2002-01-01

Enhanced false color images from mid-IR, near-IR (NIR), and visible bands of the Landsat thematic mapper (TM) are commonly used for visually interpreting land cover type. Described here is a technique for sharpening or fusion of NIR with higher resolution panchromatic (Pan) that uses a shift-invariant implementation of the discrete wavelet transform (SIDWT) and a reported pixel-based selection rule to combine coefficients. There can be contrast reversals (e.g., at soil-vegetation boundaries between NIR and visible band images) and consequently degraded sharpening and edge artifacts. To improve performance for these conditions, I used a local area-based correlation technique originally reported for comparing image-pyramid-derived edges for the adaptive processing of wavelet-derived edge data. Also, using the redundant data of the SIDWT improves edge data generation. There is additional improvement because sharpened subband imagery is used with the edge-correlation process. A reported technique for sharpening three-band spectral imagery used forward and inverse intensity, hue, and saturation transforms and wavelet-based sharpening of intensity. This technique had limitations with opposite contrast data, and in this study sharpening was applied to single-band multispectral-Pan image pairs. Sharpening used simulated 30-m NIR imagery produced by degrading the spatial resolution of a higher resolution reference. Performance, evaluated by comparison between sharpened and reference image, was improved when sharpened subband data were used with the edge correlation.

Periodic diffraction correlation imaging without a beam-splitter.

PubMed

Li, Hu; Chen, Zhipeng; Xiong, Jin; Zeng, Guihua

2012-01-30

In this paper, we proposed and demonstrated a new correlation imaging mechanism based on the periodic diffraction effect. In this effect, a periodic intensity pattern is generated at the output surface of a periodic point source array. This novel correlation imaging mechanism can realize super-resolution imaging, Nth-order ghost imaging without a beam-splitter and correlation microscopy.

High Resolution Spectrometry of Leaf and Canopy Chemistry for Biochemical Cycling

NASA Technical Reports Server (NTRS)

Spanner, M. A.; Peterson, D. L.; Acevedo, W.; Matson, P.

1985-01-01

High-resolution laboratory spectrophotometer and Airborne Imaging Spectrometer (AIS) data were used to analyze forest leaf and canopy chemistry. Fundamental stretching frequencies of organic bonds in the visible, near infrared and short-wave infrared are indicative of concentrations and total content of nitrogen, phosphorous, starch and sugar. Laboratory spectrophotometer measurements showed very strong negative correlations with nitrogen (measured using wet chemistry) in the visible wavelengths. Strong correlations with green wet canopy weight in the atmospheric water absorption windows were observed in the AIS data. A fairly strong negative correlation between the AIS data at 1500 nm and total nitrogen and nitrogen concentration was evident. This relationship corresponds very closely to protein absorption features near 1500 nm.

Correlative Light-Electron Fractography of Interlaminar Fracture in a Carbon-Epoxy Composite.

PubMed

Hein, Luis Rogerio de O; Campos, Kamila A de

2015-12-01

This work evaluates the use of light microscopes (LMs) as a tool for interlaminar fracture of polymer composite investigation with the aid of correlative fractography. Correlative fractography consists of an association of the extended depth of focus (EDF) method, based on reflected LM, with scanning electron microscopy (SEM) to evaluate interlaminar fractures. The use of these combined techniques is exemplified here for the mode I fracture of carbon-epoxy plain-weave reinforced composite. The EDF-LM is a digital image-processing method that consists of the extraction of in-focus pixels for each x-y coordinate in an image from a stack of Z-ordered digital pictures from an LM, resulting in a fully focused picture and a height elevation map for each stack. SEM is the most used tool for the identification of fracture mechanisms in a qualitative approach, with the combined advantages of a large focus depth and fine lateral resolution. However, LMs, with EDF software, may bypass the restriction on focus depth and present enough lateral resolution at low magnification. Finally, correlative fractography can provide the general comprehension of fracture processes, with the benefits of the association of different resolution scales and contrast modes.

Multiphoton autofluorescence lifetime imaging of induced pluripotent stem cells

NASA Astrophysics Data System (ADS)

Uchugonova, Aisada

2017-06-01

The multiphoton fluorescence lifetime imaging tomograph MPTflex with its flexible 360-deg scan head, articulated arm, and tunable femtosecond laser source was employed to study induced pluripotent stem cell (iPS) cultures. Autofluorescence (AF) lifetime imaging was performed with 250-ps temporal resolution and submicron spatial resolution using time-correlated single-photon counting. The two-photon excited AF was based on the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide/flavoproteins. iPS cells generated from mouse embryonic fibroblasts (MEFs) and cocultured with growth-arrested MEFs as feeder cells have been studied. Significant differences on AF lifetime signatures were identified between iPS and feeder cells as well as between their differentiating counterparts.

A new axial smoothing method based on elastic mapping

NASA Astrophysics Data System (ADS)

Yang, J.; Huang, S. C.; Lin, K. P.; Czernin, J.; Wolfenden, P.; Dahlbom, M.; Hoh, C. K.; Phelps, M. E.

1996-12-01

New positron emission tomography (PET) scanners have higher axial and in-plane spatial resolutions but at the expense of reduced per plane sensitivity, which prevents the higher resolution from being fully realized. Normally, Gaussian-weighted interplane axial smoothing is used to reduce noise. In this study, the authors developed a new algorithm that first elastically maps adjacent planes, and then the mapped images are smoothed axially to reduce the image noise level. Compared to those obtained by the conventional axial-directional smoothing method, the images by the new method have improved signal-to-noise ratio. To quantify the signal-to-noise improvement, both simulated and real cardiac PET images were studied. Various Hanning reconstruction filters with cutoff frequency=0.5, 0.7, 1.0/spl times/Nyquist frequency and Ramp filter were tested on simulated images. Effective in-plane resolution was measured by the effective global Gaussian resolution (EGGR) and noise reduction was evaluated by the cross-correlation coefficient. Results showed that the new method was robust to various noise levels and indicated larger noise reduction or better image feature preservation (i.e., smaller EGGR) than by the conventional method.

Using a pulsed laser beam to investigate the feasibility of sub-pixel position resolution with time-correlated transient signals in 3D pixelated CdZnTe detectors

DOE PAGES

Giraldo, L. Ocampo; Bolotnikov, A. E.; Camarda, G. S.; ...

2017-04-20

For this study, we evaluated the X-Y position resolution achievable in 3D pixelated detectors by processing the signal waveforms readout from neighboring pixels. In these measurements we used a focused light beam, down to 10 μm, generated by a ~1 mW pulsed laser (650 nm) to carry out raster scans over selected 3×3 pixel areas, while recording the charge signals from the 9 pixels and the cathode using two synchronized digital oscilloscopes.

Functional imaging of hippocampal place cells at cellular resolution during virtual navigation

PubMed Central

Dombeck, Daniel A.; Harvey, Christopher D.; Tian, Lin; Looger, Loren L.; Tank, David W.

2010-01-01

Spatial navigation is a widely employed behavior in rodent studies of neuronal circuits underlying cognition, learning and memory. In vivo microscopy combined with genetically-encoded indicators provides important new tools to study neuronal circuits, but has been technically difficult to apply during navigation. We describe methods to image the activity of hippocampal CA1 neurons with sub-cellular resolution in behaving mice. Neurons expressing the genetically encoded calcium indicator GCaMP3 were imaged through a chronic hippocampal window. Head-fixed mice performed spatial behaviors within a setup combining a virtual reality system and a custom built two-photon microscope. Populations of place cells were optically identified, and the correlation between the location of their place fields in the virtual environment and their anatomical location in the local circuit was measured. The combination of virtual reality and high-resolution functional imaging should allow for a new generation of studies to probe neuronal circuit dynamics during behavior. PMID:20890294

North Atlantic Tropical Cyclone Precipitation and Climate Interactions Using a High-Resolution Dataset for the Eastern United States, 1948-2015.

NASA Astrophysics Data System (ADS)

Bregy, J. C.; Maxwell, J. T.; Robeson, S. M.

2017-12-01

Tropical cyclone (TC) impacts are typically concentrated along the coast, yet some TC hazards have wider spatial distributions and affect inland regions. For example, large volumes of TC precipitation (TCP) can cause severe inland flooding, initiate slope failure, and create large sinkholes. Previous studies show that TCP contributes substantially to seasonal precipitation budgets in the eastern United States. However, present knowledge of TCP climatology in the US is limited by the spatial coverage of weather stations. Here we develop a new high resolution (0.25°x0.25°) TCP climatology using HURDAT2 and CPC US Unified Precipitation data (1948-2015). From June to November (JJASON), maximum total TCP for the study period ranges from 2200 to 3800 mm along much of the coast and decreases inland. Likewise, spatial patterns of TCP contribution to total JJASON precipitation largely mirror those of total TCP, with maxima (6-8%) located in coastal Texas and North Carolina. Similar spatial patterns are seen in the mean JJASON TCP and mean TCP contribution over the study period, with maxima extending beyond coastal Texas and North Carolina. JJASON TCP (total, mean, and contribution) was correlated with mean annual JJASON values for the Bermuda High Index (BHI), El Niño-Southern Oscillation combined Niño3.4/Southern Oscillation Index (ENSO-BEST), and North Atlantic Oscillation (NAO). Correlations between climate indices and JJASON TCP show the degree to which BHI, ENSO-BEST, and NAO influence spatiotemporal changes in TCP. Of the three indices, the BHI had the strongest and most spatially consistent correlation with TCP, with significant correlations in the interior of the southeast. These results indicate a strong regional relationship between the North Atlantic Subtropical High (NASH; represented by the BHI) and regional TCP distribution. TCP distribution depends on TC track direction, and is therefore connected to the NASH, which acts as a steering mechanism for TCs. Our derived high resolution TCP climatology further aids our understanding of TC-climate interactions. Moreover, it can be used to understand hazards associated with TCs, serving as an invaluable tool in hazard mitigation efforts.

Comparison of simultaneously recorded [H2(15)O]-PET and LORETA during cognitive and pharmacological activation.

PubMed

Gamma, Alex; Lehmann, Dietrich; Frei, Edi; Iwata, Kazuki; Pascual-Marqui, Roberto D; Vollenweider, Franz X

2004-06-01

The complementary strengths and weaknesses of established functional brain imaging methods (high spatial, low temporal resolution) and EEG-based techniques (low spatial, high temporal resolution) make their combined use a promising avenue for studying brain processes at a more fine-grained level. However, this strategy requires a better understanding of the relationship between hemodynamic/metabolic and neuroelectric measures of brain activity. We investigated possible correspondences between cerebral blood flow (CBF) as measured by [H2O]-PET and intracerebral electric activity computed by Low Resolution Brain Electromagnetic Tomography (LORETA) from scalp-recorded multichannel EEG in healthy human subjects during cognitive and pharmacological stimulation. The two imaging modalities were compared by descriptive, correlational, and variance analyses, the latter carried out using statistical parametric mapping (SPM99). Descriptive visual comparison showed a partial overlap between the sets of active brain regions detected by the two modalities. A number of exclusively positive correlations of neuroelectric activity with regional CBF were found across the whole EEG frequency range, including slow wave activity, the latter finding being in contrast to most previous studies conducted in patients. Analysis of variance revealed an extensive lack of statistically significant correspondences between brain activity changes as measured by PET vs. EEG-LORETA. In general, correspondences, to the extent they were found, were dependent on experimental condition, brain region, and EEG frequency. Copyright 2004 Wiley-Liss, Inc.

The interpretation of remotely sensed cloud properties from a model paramterization perspective

NASA Technical Reports Server (NTRS)

HARSHVARDHAN; Wielicki, Bruce A.; Ginger, Kathryn M.

1994-01-01

A study has been made of the relationship between mean cloud radiative properties and cloud fraction in stratocumulus cloud systems. The analysis is of several Land Resources Satellite System (LANDSAT) images and three hourly International Satellite Cloud Climatology Project (ISCCP) C-1 data during daylight hours for two grid boxes covering an area typical of a general circulation model (GCM) grid increment. Cloud properties were inferred from the LANDSAT images using two thresholds and several pixel resolutions ranging from roughly 0.0625 km to 8 km. At the finest resolution, the analysis shows that mean cloud optical depth (or liquid water path) increases somewhat with increasing cloud fraction up to 20% cloud coverage. More striking, however, is the lack of correlation between the two quantities for cloud fractions between roughly 0.2 and 0.8. When the scene is essentially overcast, the mean cloud optical tends to be higher. Coarse resolution LANDSAT analysis and the ISCCP 8-km data show lack of correlation between mean cloud optical depth and cloud fraction for coverage less than about 90%. This study shows that there is perhaps a local mean liquid water path (LWP) associated with partly cloudy areas of stratocumulus clouds. A method has been suggested to use this property to construct the cloud fraction paramterization in a GCM when the model computes a grid-box-mean LWP.

The impact of the resolution of meteorological datasets on catchment-scale drought studies

NASA Astrophysics Data System (ADS)

Hellwig, Jost; Stahl, Kerstin

2017-04-01

Gridded meteorological datasets provide the basis to study drought at a range of scales, including catchment scale drought studies in hydrology. They are readily available to study past weather conditions and often serve real time monitoring as well. As these datasets differ in spatial/temporal coverage and spatial/temporal resolution, for most studies there is a tradeoff between these features. Our investigation examines whether biases occur when studying drought on catchment scale with low resolution input data. For that, a comparison among the datasets HYRAS (covering Central Europe, 1x1 km grid, daily data, 1951 - 2005), E-OBS (Europe, 0.25° grid, daily data, 1950-2015) and GPCC (whole world, 0.5° grid, monthly data, 1901 - 2013) is carried out. Generally, biases in precipitation increase with decreasing resolution. Most important variations are found during summer. In low mountain range of Central Europe the datasets of sparse resolution (E-OBS, GPCC) overestimate dry days and underestimate total precipitation since they are not able to describe high spatial variability. However, relative measures like the correlation coefficient reveal good consistencies of dry and wet periods, both for absolute precipitation values and standardized indices like the Standardized Precipitation Index (SPI) or Standardized Precipitation Evaporation Index (SPEI). Particularly the most severe droughts derived from the different datasets match very well. These results indicate that absolute values of sparse resolution datasets applied to catchment scale might be critical to use for an assessment of the hydrological drought at catchment scale, whereas relative measures for determining periods of drought are more trustworthy. Therefore, studies on drought, that downscale meteorological data, should carefully consider their data needs and focus on relative measures for dry periods if sufficient for the task.

Search for Cross-Correlations of Ultrahigh-Energy Cosmic Rays with BL Lacertae Objects

NASA Astrophysics Data System (ADS)

Abbasi, R. U.; Abu-Zayyad, T.; Amann, J. F.; Archbold, G.; Belov, K.; Belz, J. W.; BenZvi, S.; Bergman, D. R.; Blake, S. A.; Boyer, J. H.; Burt, G. W.; Cao, Z.; Connolly, B. M.; Deng, W.; Fedorova, Y.; Findlay, J.; Finley, C. B.; Hanlon, W. F.; Hoffman, C. M.; Holzscheiter, M. H.; Hughes, G. A.; Hüntemeyer, P.; Jui, C. C. H.; Kim, K.; Kirn, M. A.; Knapp, B. C.; Loh, E. C.; Maestas, M. M.; Manago, N.; Mannel, E. J.; Marek, L. J.; Martens, K.; Matthews, J. A. J.; Matthews, J. N.; O'Neill, A.; Painter, C. A.; Perera, L.; Reil, K.; Riehle, R.; Roberts, M. D.; Rodriguez, D.; Sasaki, M.; Schnetzer, S. R.; Seman, M.; Sinnis, G.; Smith, J. D.; Snow, R.; Sokolsky, P.; Springer, R. W.; Stokes, B. T.; Thomas, J. R.; Thomas, S. B.; Thomson, G. B.; Tupa, D.; Westerhoff, S.; Wiencke, L. R.; Zech, A.; HIRES Collaboration

2006-01-01

Data taken in stereo mode by the High Resolution Fly's Eye (HiRes) air fluorescence experiment are analyzed to search for correlations between the arrival directions of ultrahigh-energy cosmic rays with the positions of BL Lacertae objects. Several previous claims of significant correlations between BL Lac objects and cosmic rays observed by other experiments are tested. These claims are not supported by the HiRes data. However, we verify a recent analysis of correlations between HiRes events and a subset of confirmed BL Lac objects from the 10th Veron Catalog, and we study this correlation in detail. Due to the a posteriori nature of the search, the significance level cannot be reliably estimated and the correlation must be tested independently before any claim can be made. We identify the precise hypotheses that will be tested with statistically independent data.

Fluorescence correlation spectroscopy: novel variations of an established technique.

PubMed

Haustein, Elke; Schwille, Petra

2007-01-01

Fluorescence correlation spectroscopy (FCS) is one of the major biophysical techniques used for unraveling molecular interactions in vitro and in vivo. It allows minimally invasive study of dynamic processes in biological specimens with extremely high temporal and spatial resolution. By recording and correlating the fluorescence fluctuations of single labeled molecules through the exciting laser beam, FCS gives information on molecular mobility and photophysical and photochemical reactions. By using dual-color fluorescence cross-correlation, highly specific binding studies can be performed. These have been extended to four reaction partners accessible by multicolor applications. Alternative detection schemes shift accessible time frames to slower processes (e.g., scanning FCS) or higher concentrations (e.g., TIR-FCS). Despite its long tradition, FCS is by no means dated. Rather, it has proven to be a highly versatile technique that can easily be adapted to solve specific biological questions, and it continues to find exciting applications in biology and medicine.

Correlated optical and isotopic nanoscopy

NASA Astrophysics Data System (ADS)

Saka, Sinem K.; Vogts, Angela; Kröhnert, Katharina; Hillion, François; Rizzoli, Silvio O.; Wessels, Johannes T.

2014-04-01

The isotopic composition of different materials can be imaged by secondary ion mass spectrometry. In biology, this method is mainly used to study cellular metabolism and turnover, by pulsing the cells with marker molecules such as amino acids labelled with stable isotopes (15N, 13C). The incorporation of the markers is then imaged with a lateral resolution that can surpass 100 nm. However, secondary ion mass spectrometry cannot identify specific subcellular structures like organelles, and needs to be correlated with a second technique, such as fluorescence imaging. Here, we present a method based on stimulated emission depletion microscopy that provides correlated optical and isotopic nanoscopy (COIN) images. We use this approach to study the protein turnover in different organelles from cultured hippocampal neurons. Correlated optical and isotopic nanoscopy can be applied to a variety of biological samples, and should therefore enable the investigation of the isotopic composition of many organelles and subcellular structures.

Singularity resolution in string theory and new quantum condensed matter phases

NASA Astrophysics Data System (ADS)

Fidkowski, Lukasz

2007-12-01

In the first part of this thesis (chapters 1 through 4) we study singularity resolution in string theory. We employ an array of techniques, including the AdS-CFT correspondence, exact solvability of low dimensional models, and supersymmetry. We are able to detect a signature of the black hole singularity by analytically continuing certain AdS-CFT correlators. Also in AdS-CFT, we are able to study a D-brane snapping transition on both sides of the correspondence. In the second part (chapters 5 through 7) we study topological phases in condensed matter systems. We investigate theoretical lattice models realizing such phases, use these to derive nontrivial mathematical physics results, and study an idealized quantum interferometer designed to detect such a phase in quantum Hall systems.

Structural functional associations of the orbit in thyroid eye disease: Kalman filters to track extraocular rectal muscles

NASA Astrophysics Data System (ADS)

Chaganti, Shikha; Nelson, Katrina; Mundy, Kevin; Luo, Yifu; Harrigan, Robert L.; Damon, Steve; Fabbri, Daniel; Mawn, Louise; Landman, Bennett

2016-03-01

Pathologies of the optic nerve and orbit impact millions of Americans and quantitative assessment of the orbital structures on 3-D imaging would provide objective markers to enhance diagnostic accuracy, improve timely intervention, and eventually preserve visual function. Recent studies have shown that the multi-atlas methodology is suitable for identifying orbital structures, but challenges arise in the identification of the individual extraocular rectus muscles that control eye movement. This is increasingly problematic in diseased eyes, where these muscles often appear to fuse at the back of the orbit (at the resolution of clinical computed tomography imaging) due to inflammation or crowding. We propose the use of Kalman filters to track the muscles in three-dimensions to refine multi-atlas segmentation and resolve ambiguity due to imaging resolution, noise, and artifacts. The purpose of our study is to investigate a method of automatically generating orbital metrics from CT imaging and demonstrate the utility of the approach by correlating structural metrics of the eye orbit with clinical data and visual function measures in subjects with thyroid eye disease. The pilot study demonstrates that automatically calculated orbital metrics are strongly correlated with several clinical characteristics. Moreover, it is shown that the superior, inferior, medial and lateral rectus muscles obtained using Kalman filters are each correlated with different categories of functional deficit. These findings serve as foundation for further investigation in the use of CT imaging in the study, analysis and diagnosis of ocular diseases, specifically thyroid eye disease.

Three- α particle correlations in quasi-projectile decay in 12C + 24Mg collisions at 35A MeV

NASA Astrophysics Data System (ADS)

Quattrocchi, L.; Acosta, L.; Amorini, F.; Anzalone, A.; Auditore, L.; Berceanu, I.; Cardella, G.; Chbihi, A.; De Filippo, E.; De Luca, S.; Dell'Aquila, D.; Francalanza, L.; Gnoffo, B.; Grzeszczuk, A.; Lanzalone, G.; Lombardo, I.; Martel, I.; Martorana, N. S.; Minniti, T.; Norella, S.; Pagano, A.; Pagano, E. V.; Papa, M.; Pirrone, S.; Politi, G.; Porto, F.; Rizzo, F.; Rosato, E.; Russotto, P.; Trifirò, A.; Trimarchi, M.; Verde, G.; Veselsky, M.; Vigilante, M.

2017-11-01

Two and multi particle correlations have been studied in peripheral 12C + 24Mg collisions at 35A MeV with CHIMERA 4 π multi detector, in order to explore resonances produced in light nuclei. Correlations techniques have become a tool to explore nuclear structure properties but also to evaluate the competition between simultaneous and sequential channels in decay of light isotopes. The exploration of features such as branching ratios with respect to different decay channels (sequential vs. simultaneous) could provide information on in-medium effects on nuclear structure properties, an important perspective for research on the nuclear interaction. The performed experiment is preliminary to further studies to be performed by coupling of CHIMERA to FARCOS (Femtoscope ARray for COrrelations and Spectroscopy, FARCOS TDR available at https://drive.google.com/file/d/0B5CgGWz8LpOOc3pGTWdOcDBoWFE) array devoted to measurements of two and multi particle correlations with high energy and angular resolutions.

Risk and Resolution: The Influence of Presidential Personality Predispositions on Military Disengagement Decisions

DTIC Science & Technology

2014-01-01

personality. Their Five Factor Model ( FFM ) melds characteristics found in nearly all personality and psychological tests. The model consists of...and Costa found MBTI scales to correlate strongly with four of the five FFM traits: MBTI-Introversion correlates negatively to FFM Extraversion, MBTI...N correlates positively to FFM Openness, MBTI-Feeling correlates positively to FFM Agreeableness, and MBTI-P correlates negatively to FFM

An ultrasonic pseudorandom signal-correlation system

NASA Astrophysics Data System (ADS)

Elias, C. M.

1980-01-01

A working ultrasonic pseudorandom signal-correlation system is described which, unlike ultrasonic random signal-correlation systems, does not require an acoustic delay line. Elimination of the delay line allows faster data acquisition and better range resolution. The system uses two identical shift-register type generators to produce pseudonoise bursts which are subsequences of a 65 535-bit complementary m-sequence. One generator produces the transmitted bursts while the other generates identical reference bursts which start at a variable correlation delay time after the transmitted bursts. The reference bursts are cross-correlated with the received echoes to obtain the approximate impulse response of the transducer/specimen system under test. Range sidelobes are reduced by transmitting and correlating many bursts at a given correlation delay before incrementing the delay. Signal-to-sidelobe ratios of greater than 47 dB have been obtained using this method. Limitations of the system due to sampling constraints and the pseudonoise power spectrum are discussed, and the system design and implementation are outlined. Results of experimental characterization of the system show that the pseudorandom signal-correlation system has approximately the same range resolution as a conventional pulse-echo system but can yield a significant increase in signal-to-noise ratio (SNR).

Raman spectroscopy-based detection of chemical contaminants in food powders

NASA Astrophysics Data System (ADS)

Chao, Kuanglin; Dhakal, Sagar; Qin, Jianwei; Kim, Moon; Bae, Abigail

2016-05-01

Raman spectroscopy technique has proven to be a reliable method for qualitative detection of chemical contaminants in food ingredients and products. For quantitative imaging-based detection, each contaminant particle in a food sample must be detected and it is important to determine the necessary spatial resolution needed to effectively detect the contaminant particles. This study examined the effective spatial resolution required for detection of maleic acid in tapioca starch and benzoyl peroxide in wheat flour. Each chemical contaminant was mixed into its corresponding food powder at a concentration of 1% (w/w). Raman spectral images were collected for each sample, leveled across a 45 mm x 45 mm area, using different spatial resolutions. Based on analysis of these images, a spatial resolution of 0.5mm was selected as effective spatial resolution for detection of maleic acid in starch and benzoyl peroxide in flour. An experiment was then conducted using the 0.5mm spatial resolution to demonstrate Raman imaging-based quantitative detection of these contaminants for samples prepared at 0.1%, 0.3%, and 0.5% (w/w) concentrations. The results showed a linear correlation between the detected numbers of contaminant pixels and the actual concentrations of contaminant.

Speckle correlation resolution enhancement of wide-field fluorescence imaging (Conference Presentation)

NASA Astrophysics Data System (ADS)

Yilmaz, Hasan

2016-03-01

Structured illumination enables high-resolution fluorescence imaging of nanostructures [1]. We demonstrate a new high-resolution fluorescence imaging method that uses a scattering layer with a high-index substrate as a solid immersion lens [2]. Random scattering of coherent light enables a speckle pattern with a very fine structure that illuminates the fluorescent nanospheres on the back surface of the high-index substrate. The speckle pattern is raster-scanned over the fluorescent nanospheres using a speckle correlation effect known as the optical memory effect. A series of standard-resolution fluorescence images per each speckle pattern displacement are recorded by an electron-multiplying CCD camera using a commercial microscope objective. We have developed a new phase-retrieval algorithm to reconstruct a high-resolution, wide-field image from several standard-resolution wide-field images. We have introduced phase information of Fourier components of standard-resolution images as a new constraint in our algorithm which discards ambiguities therefore ensures convergence to a unique solution. We demonstrate two-dimensional fluorescence images of a collection of nanospheres with a deconvolved Abbe resolution of 116 nm and a field of view of 10 µm × 10 µm. Our method is robust against optical aberrations and stage drifts, therefore excellent for imaging nanostructures under ambient conditions. [1] M. G. L. Gustafsson, J. Microsc. 198, 82-87 (2000). [2] H. Yilmaz, E. G. van Putten, J. Bertolotti, A. Lagendijk, W. L. Vos, and A. P. Mosk, Optica 2, 424-429 (2015).

Association of High-Resolution Manometry Metrics with the Symptoms of Achalasia and the Symptomatic Outcomes of Peroral Esophageal Myotomy

PubMed Central

Tang, Yurong; Xie, Chen; Wang, Meifeng; Jiang, Liuqin; Shi, Ruihua; Lin, Lin

2015-01-01

Background High-resolution manometry (HRM) has improved the accuracy of manometry in detecting achalasia and has helped distinguish between clinically relevant subtypes. This study investigated whether HRM metrics correlate with the achalasia symptoms and symptomatic outcomes of peroral esophageal myotomy (POEM). Methods Of the 30 patients who were enrolled, 25 were treated with POEM, 12 of who underwent HRM after 3 months. All the patients completed the Eckardt score questionnaires, and those who underwent POEM were followed up for about 6 months. Pearson correlation was used to assess the relationship between the HRM metrics and symptoms and outcomes. Key results The integrated relaxation pressure (IRP) score positively correlated with the total Eckardt score, regurgitation score and weight loss score in all the patients, and with the weight loss score in type I achalasia. In 25 patients (10 patients, type I; 15 patients, type II) who underwent POEM, the total Eckardt scores and individual symptom scores significantly decreased after surgery. Changes in the Eckardt scores were similar between type I and type II. Further, the Eckardt scores and weight loss score changes were positively correlated with baseline IRP. Twelve patients (4 patients, type I; 8 patients, type II) underwent HRM again after POEM. IRP changed significantly after POEM, as did the DEP in type II. The IRP changes after POEM were positively correlated with the Eckardt score changes. Conclusions & Inferences IRP is correlated with the symptoms and outcomes of achalasia patients. Thus, HRM is effective for assessing the severity of achalasia and can predict the efficacy of POEM. PMID:26421919

Association of High-Resolution Manometry Metrics with the Symptoms of Achalasia and the Symptomatic Outcomes of Peroral Esophageal Myotomy.

PubMed

Tang, Yurong; Xie, Chen; Wang, Meifeng; Jiang, Liuqin; Shi, Ruihua; Lin, Lin

2015-01-01

High-resolution manometry (HRM) has improved the accuracy of manometry in detecting achalasia and has helped distinguish between clinically relevant subtypes. This study investigated whether HRM metrics correlate with the achalasia symptoms and symptomatic outcomes of peroral esophageal myotomy (POEM). Of the 30 patients who were enrolled, 25 were treated with POEM, 12 of who underwent HRM after 3 months. All the patients completed the Eckardt score questionnaires, and those who underwent POEM were followed up for about 6 months. Pearson correlation was used to assess the relationship between the HRM metrics and symptoms and outcomes. The integrated relaxation pressure (IRP) score positively correlated with the total Eckardt score, regurgitation score and weight loss score in all the patients, and with the weight loss score in type I achalasia. In 25 patients (10 patients, type I; 15 patients, type II) who underwent POEM, the total Eckardt scores and individual symptom scores significantly decreased after surgery. Changes in the Eckardt scores were similar between type I and type II. Further, the Eckardt scores and weight loss score changes were positively correlated with baseline IRP. Twelve patients (4 patients, type I; 8 patients, type II) underwent HRM again after POEM. IRP changed significantly after POEM, as did the DEP in type II. The IRP changes after POEM were positively correlated with the Eckardt score changes. IRP is correlated with the symptoms and outcomes of achalasia patients. Thus, HRM is effective for assessing the severity of achalasia and can predict the efficacy of POEM.

Identifying in vivo DCE MRI markers associated with microvessel architecture and gleason grades of prostate cancer.

PubMed

Singanamalli, Asha; Rusu, Mirabela; Sparks, Rachel E; Shih, Natalie N C; Ziober, Amy; Wang, Li-Ping; Tomaszewski, John; Rosen, Mark; Feldman, Michael; Madabhushi, Anant

2016-01-01

To identify computer extracted in vivo dynamic contrast enhanced (DCE) MRI markers associated with quantitative histomorphometric (QH) characteristics of microvessels and Gleason scores (GS) in prostate cancer. This study considered retrospective data from 23 biopsy confirmed prostate cancer patients who underwent 3 Tesla multiparametric MRI before radical prostatectomy (RP). Representative slices from RP specimens were stained with vascular marker CD31. Tumor extent was mapped from RP sections onto DCE MRI using nonlinear registration methods. Seventy-seven microvessel QH features and 18 DCE MRI kinetic features were extracted and evaluated for their ability to distinguish low from intermediate and high GS. The effect of temporal sampling on kinetic features was assessed and correlations between those robust to temporal resolution and microvessel features discriminative of GS were examined. A total of 12 microvessel architectural features were discriminative of low and intermediate/high grade tumors with area under the receiver operating characteristic curve (AUC) > 0.7. These features were most highly correlated with mean washout gradient (WG) (max rho = -0.62). Independent analysis revealed WG to be moderately robust to temporal resolution (intraclass correlation coefficient [ICC] = 0.63) and WG variance, which was poorly correlated with microvessel features, to be predictive of low grade tumors (AUC = 0.77). Enhancement ratio was the most robust (ICC = 0.96) and discriminative (AUC = 0.78) kinetic feature but was moderately correlated with microvessel features (max rho = -0.52). Computer extracted features of prostate DCE MRI appear to be correlated with microvessel architecture and may be discriminative of low versus intermediate and high GS. © 2015 Wiley Periodicals, Inc.

Optical long baseline intensity interferometry: prospects for stellar physics

NASA Astrophysics Data System (ADS)

Rivet, Jean-Pierre; Vakili, Farrokh; Lai, Olivier; Vernet, David; Fouché, Mathilde; Guerin, William; Labeyrie, Guillaume; Kaiser, Robin

2018-06-01

More than sixty years after the first intensity correlation experiments by Hanbury Brown and Twiss, there is renewed interest for intensity interferometry techniques for high angular resolution studies of celestial sources. We report on a successful attempt to measure the bunching peak in the intensity correlation function for bright stellar sources with 1 meter telescopes (I2C project). We propose further improvements of our preliminary experiments of spatial interferometry between two 1 m telescopes, and discuss the possibility to export our method to existing large arrays of telescopes.

Reduction of space charge effects and tests of larger samples of photomultipliers for the EDDA experiment

NASA Astrophysics Data System (ADS)

Ackerstaff, K.; Bisplinghoff, J.; Bollmann, R.; Cloth, P.; Dohrmann, F.; Diehl, O.; Dorner, G.; Drüke, V.; Engelhardt, H. J.; Eisenhardt, S.; Ernst, J.; Eversheim, P. D.; Filges, D.; Fritz, S.; Gasthuber, M.; Gebel, R.; Gross, A.; Gross-Hardt, R.; Hinterberger, F.; Jahn, R.; Lahr, U.; Langkau, R.; Lippert, G.; Mayer-Kuckuk, T.; Maschuw, R.; Mertler, G.; Metsch, B.; Mosel, F.; Paetz gen. Schieck, H.; Petry, H. R.; Prasuhn, D.; v. Przewoski, B.; Radtke, M.; Rohdjess, H.; Rosendaal, D.; von Rossen, P.; Scheid, H.; Schirm, N.; Schwandt, F.; Scobel, W.; Theis, D.; Weber, J.; Wiedmann, W.; Woller, K.; Ziegler, R.; EDDA Collaboration

1993-10-01

For the EDDA experiment at COSY, the response of the small, linear focused photomultipliers Hamamatsu R 1450 and R 1355 has been studied with fast light pulses generating yields up to 2 × 10 3 photoelectrons/cm 2 or peak currents of 24 mA. Linearity was obtained with a tapered bleeder chain at a tolerable loss of gain. The serial test of altogether 140 photomultipliers revealed the close correlation between single electron and amplitude resolution. The influence of the photoelectron statistics on this correlation is discussed.

Reconstruction of a Three Hourly 1-km Land Surface Air Temperature Dataset in the Qinghai-Tibet Plateau

NASA Astrophysics Data System (ADS)

Zhou, J.; Ding, L.

2017-12-01

Land surface air temperature (SAT) is an important parameter in the modeling of radiation balance and energy budget of the earth surface. Generally, SAT is measured at ground meteorological stations; then SAT mapping is possible though a spatial interpolation process. The interpolated SAT map relies on the spatial distribution of ground stations, the terrain, and many other factors; thus, it has great uncertainties in regions with complicated terrain. Instead, SAT map can also be obtained through physical modeling of interactions between the land surface and the atmosphere. Such dataset generally has coarse spatial resolution (e.g. coarser than 0.1°) and cannot satisfy the applications at fine scales, e.g. 1 km. This presentation reports the reconstruction of a three hourly 1-km SAT dataset from 2001 to 2015 over the Qinghai-Tibet Plateau. The terrain in the Qinghai-Tibet Plateau, especially in the eastern part, is extremely complicated. Two SAT datasets with good qualities are used in this study. The first one is from the 3h China Meteorological Forcing Dataset with a 0.1° resolution released by the Institute of Tibetan Plateau Research, Chinese Academy of Sciences (Yang et al., 2010); the second one is from the ERA-Interim product with the same temporal resolution and a 0.125° resolution. A statistical approach is developed to downscale the spatial resolution of the derived SAT to 1-km. The elevation and the normalized difference vegetation index (NDVI) are selected as two scaling factors in the downscaling approach. Results demonstrate there is significantly negative correlation between the SAT and elevation in all seasons; there is also significantly negative correlation between the SAT and NDVI in the vegetation growth seasons, while the correlation decreases in the other seasons. Therefore, a temporally dynamic downscaling approach is feasible to enhance the spatial resolution of the SAT. Compared with the SAT at the 0.1° or 0.125°, the reconstructed 1-km SAT can provide much more spatial details in areas with complicated terrain. Additionally, the 1-km SAT agrees well with the ground measured air temperatures as well as the SAT before downscaling. The reconstructed SAT will be beneficial for the modeling of surface radiation balance and energy budget over the Qinghai-Tibet Plateau.

Performance highlights of the ALMA correlators

NASA Astrophysics Data System (ADS)

Baudry, Alain; Lacasse, Richard; Escoffier, Ray; Webber, John; Greenberg, Joseph; Platt, Laurence; Treacy, Robert; Saez, Alejandro F.; Cais, Philippe; Comoretto, Giovanni; Quertier, Benjamin; Okumura, Sachiko K.; Kamazaki, Takeshi; Chikada, Yoshihiro; Watanabe, Manabu; Okuda, Takeshi; Kurono, Yasutake; Iguchi, Satoru

2012-09-01

Two large correlators have been constructed to combine the signals captured by the ALMA antennas deployed on the Atacama Desert in Chile at an elevation of 5050 meters. The Baseline correlator was fabricated by a NRAO/European team to process up to 64 antennas for 16 GHz bandwidth in two polarizations and another correlator, the Atacama Compact Array (ACA) correlator, was fabricated by a Japanese team to process up to 16 antennas. Both correlators meet the same specifications except for the number of processed antennas. The main architectural differences between these two large machines will be underlined. Selected features of the Baseline and ACA correlators as well as the main technical challenges met by the designers will be briefly discussed. The Baseline correlator is the largest correlator ever built for radio astronomy. Its digital hybrid architecture provides a wide variety of observing modes including the ability to divide each input baseband into 32 frequency-mobile sub-bands for high spectral resolution and to be operated as a conventional 'lag' correlator for high time resolution. The various observing modes offered by the ALMA correlators to the science community for 'Early Science' are presented, as well as future observing modes. Coherently phasing the array to provide VLBI maps of extremely compact sources is another feature of the ALMA correlators. Finally, the status and availability of these large machines will be presented.

Can we observe the fronts of the Antarctic Circumpolar Current using GRACE OBP?

NASA Astrophysics Data System (ADS)

Makowski, J.; Chambers, D. P.; Bonin, J. A.

2014-12-01

The Antarctic Circumpolar Current (ACC) and the Southern Ocean remains one of the most undersampled regions of the world's oceans. The ACC is comprised of four major fronts: the Sub-Tropical Front (STF), the Polar Front (PF), the Sub-Antarctic Front (SAF), and the Southern ACC Front (SACCF). These were initially observed individually from repeat hydrographic sections and their approximate locations globally have been quantified using all available temperature data from the World Ocean and Climate Experiment (WOCE). More recent studies based on satellite altimetry have found that the front positions are more dynamic and have shifted south by up to 1° on average since 1993. Using ocean bottom pressure (OBP) data from the current Gravity Recovery and Climate Experiment (GRACE) we have measured integrated transport variability of the ACC south of Australia. However, differentiation of variability of specific fronts has been impossible due to the necessary smoothing required to reduce noise and correlated errors in the measurements. The future GRACE Follow-on (GFO) mission and the post 2020 GRACE-II mission are expected to produce higher resolution gravity fields with a monthly temporal resolution. Here, we study the resolution and error characteristics of GRACE gravity data that would be required to resolve variations in the front locations and transport. To do this, we utilize output from a high-resolution model of the Southern Ocean, hydrology models, and ice sheet surface mass balance models; add various amounts of random and correlated errors that may be expected from GFO and GRACE-II; and quantify requirements needed for future satellite gravity missions to resolve variations along the ACC fronts.

Source-to-Sink Methods by Hyperspectral Imaging: a Case Study of the Laminated Sediments of Lake Linné (Svalbard).

NASA Astrophysics Data System (ADS)

Van Exem, A.; Debret, M.; Copard, Y.; Verpoorter, C.; Sorrel, P.; de Wet, G.; Werner, A.; Roof, S.; Laignel, B.; Retelle, M.

2016-12-01

Laminated sediments contained valuable information recorded on a micrometric scale. Information about sediments flux and origins require high-resolution source tracking analysis. Quick and non-destructive, hyperspectral imaging provides contiguous reflectance datasets into 2 dimensions with a spatial resolution of 0.02 mm. Located on the west of the Spitzbergen, Lake Linné is the largest lake in the region. Erosion is mainly driven by glacier fluctuations and three different bedrocks are potential sediment sources. Organic matter (coal) is only found in some carboniferous rocks. Four cores recovered from different parts of the lake contain millimeter scale laminae. Two approaches were compared: (i) measurement of statistical correlations between the sediments and source samples, (ii) extraction of extreme spectral signatures from the VNIR hyperspectral images. Total Organic Carbon (TOC) values of all samples were also given by bulk geochemistry (RE6 ® pyrolyzer). Consequently, the measured similarity between the hyperspectral image and the field samples illustrates the sources contribution within the core. Three sample clusters and three equivalent spectral signatures were found. TOC values from the archive show good correlation (r=0.86, p<0.001, n=73) with the hyperspectral signature relative to TOC content. A least-squares regression (r²=0.74) was used to extrapolate TOC values in order to represent their distribution at 0.02 mm resolution. This is the first source-to-sink study based on imaging spectroscopy. Our results indicate that hyperspectral imagery is a useful tool to (i) identify sediment sources, (ii) perform continuous paleo-environmental reconstruction at high resolution, and (iii) can provide quantitative results (TOC values) validated by destructive analyses.

A Compact L-band Radiometer for High Resolution sUAS-based Imaging of Soil Moisture and Surface Salinity Variations

NASA Astrophysics Data System (ADS)

Gasiewski, A. J.; Stachura, M.; Dai, E.; Elston, J.; McIntyre, E.; Leuski, V.

2014-12-01

Due to the long electrical wavelengths required along with practical aperture size limitations the scaling of passive microwave remote sensing of soil moisture and salinity from spaceborne low-resolution (~10-100 km) applications to high resolution (~10-1000 m) applications requires use of low flying aerial vehicles. This presentation summarizes the status of a project to develop a commercial small Unmanned Aerial System (sUAS) hosting a microwave radiometer for mapping of soil moisture in precision agriculture and sea surface salinity studies. The project is based on the Tempest electric-powered UAS and a compact L-band (1400-1427 MHz) radiometer developed specifically for extremely small and lightweight aerial platforms or man-portable, tractor, or tower-based applications. Notable in this combination are a highly integrated sUAS/radiometer antenna design and use of both the upwelling emitted signal from the surface and downwelling cold space signal for precise calibration using a unique lobe-differencing correlating radiometer architecture. The system achieves a spatial resolution comparable to the altitude of the UAS above the surface while referencing upwelling measurements to the constant and well-known background temperature of cold space. The radiometer has been tested using analog correlation detection, although future builds will include infrared, near-infrared, and visible (red) sensors for surface temperature and vegetation biomass correction and digital sampling for radio frequency interference mitigation. This NASA-sponsored project is being developed for commercial application in cropland water management (for example, high-value shallow root-zone crops), landslide risk assessment, NASA SMAP satellite validation, and NASA Aquarius salinity stratification studies. The system will ultimately be capable of observing salinity events caused by coastal glacier and estuary fresh water outflow plumes and open ocean rainfall events.

High resolution ultrasound and magnetic resonance imaging of the optic nerve and the optic nerve sheath: anatomic correlation and clinical importance.

PubMed

Steinborn, M; Fiegler, J; Kraus, V; Denne, C; Hapfelmeier, A; Wurzinger, L; Hahn, H

2011-12-01

We performed a cadaver study to evaluate the accuracy of measurements of the optic nerve and the optic nerve sheath for high resolution US (HRUS) and magnetic resonance imaging (MRI). Five Thiel-fixated cadaver specimens of the optic nerve were examined with HRUS and MRI. Measurements of the optic nerve and the ONSD were performed before and after the filling of the optic nerve sheath with saline solution. Statistical analysis included the calculation of the agreement of measurements and the evaluation of the intraobserver and interobserver variation. Overall a good correlation of measurement values between HRUS and MRI can be found (mean difference: 0.02-0.97 mm). The repeatability coefficient (RC) and concordance correlation coefficient (CCC) values were good to excellent for most acquisitions (RC 0.2-1.11 mm; CCC 0.684-0.949). The highest variation of measurement values was found for transbulbar sonography (RC 0.58-1.83 mm; CCC 0.615/0.608). If decisive anatomic structures are clearly depicted and the measuring points are set correctly, there is a good correlation between HRUS and MRI measurements of the optic nerve and the ONSD even on transbulbar sonography. As most of the standard and cut-off values that have been published for ultrasound are significantly lower than the results obtained with MRI, a reevaluation of sonographic ONSD measurement with correlation to MRI is necessary. © Georg Thieme Verlag KG Stuttgart · New York.

Digital tomosynthesis and high resolution computed tomography as clinical tools for vertebral endplate topography measurements: Comparison with microcomputed tomography.

PubMed

Oravec, Daniel; Quazi, Abrar; Xiao, Angela; Yang, Ellen; Zauel, Roger; Flynn, Michael J; Yeni, Yener N

2015-12-01

Endplate morphology is understood to play an important role in the mechanical behavior of vertebral bone as well as degenerative processes in spinal tissues; however, the utility of clinical imaging modalities in assessment of the vertebral endplate has been limited. The objective of this study was to evaluate the ability of two clinical imaging modalities (digital tomosynthesis, DTS; high resolution computed tomography, HRCT) to assess endplate topography by correlating the measurements to a microcomputed tomography (μCT) standard. DTS, HRCT, and μCT images of 117 cadaveric thoracolumbar vertebrae (T10-L1; 23 male, 19 female; ages 36-100 years) were segmented, and inferior and superior endplate surface topographical distribution parameters were calculated. Both DTS and HRCT showed statistically significant correlations with μCT approaching a moderate level of correlation at the superior endplate for all measured parameters (R(2)Adj=0.19-0.57), including averages, variability, and higher order statistical moments. Correlation of average depths at the inferior endplate was comparable to the superior case for both DTS and HRCT (R(2)Adj=0.14-0.51), while correlations became weak or nonsignificant for higher moments of the topography distribution. DTS was able to capture variations in the endplate topography to a slightly better extent than HRCT, and taken together with the higher speed and lower radiation cost of DTS than HRCT, DTS appears preferable for endplate measurements. Copyright © 2015 Elsevier Inc. All rights reserved.

Assessing the Chemical Accuracy of Protein Structures via Peptide Acidity

PubMed Central

Anderson, Janet S.; Hernández, Griselda; LeMaster, David M.

2012-01-01

Although the protein native state is a Boltzmann conformational ensemble, practical applications often require a representative model from the most populated region of that distribution. The acidity of the backbone amides, as reflected in hydrogen exchange rates, is exquisitely sensitive to the surrounding charge and dielectric volume distribution. For each of four proteins, three independently determined X-ray structures of differing crystallographic resolution were used to predict exchange for the static solvent-exposed amide hydrogens. The average correlation coefficients range from 0.74 for ubiquitin to 0.93 for Pyrococcus furiosus rubredoxin, reflecting the larger range of experimental exchange rates exhibited by the latter protein. The exchange prediction errors modestly correlate with the crystallographic resolution. MODELLER 9v6-derived homology models at ~60% sequence identity (36% identity for chymotrypsin inhibitor CI2) yielded correlation coefficients that are ~0.1 smaller than for the cognate X-ray structures. The most recently deposited NOE-based ubiquitin structure and the original NMR structure of CI2 fail to provide statistically significant predictions of hydrogen exchange. However, the more recent RECOORD refinement study of CI2 yielded predictions comparable to the X-ray and homology model-based analyses. PMID:23182463

Comparison of two Simon tasks: neuronal correlates of conflict resolution based on coherent motion perception.

PubMed

Wittfoth, Matthias; Buck, Daniela; Fahle, Manfred; Herrmann, Manfred

2006-08-15

The present study aimed at characterizing the neural correlates of conflict resolution in two variations of the Simon effect. We introduced two different Simon tasks where subjects had to identify shapes on the basis of form-from-motion perception (FFMo) within a randomly moving dot field, while (1) motion direction (motion-based Simon task) or (2) stimulus location (location-based Simon task) had to be ignored. Behavioral data revealed that both types of Simon tasks induced highly significant interference effects. Using event-related fMRI, we could demonstrate that both tasks share a common cluster of activated brain regions during conflict resolution (pre-supplementary motor area (pre-SMA), superior parietal lobule (SPL), and cuneus) but also show task-specific activation patterns (left superior temporal cortex in the motion-based, and the left fusiform gyrus in the location-based Simon task). Although motion-based and location-based Simon tasks are conceptually very similar (Type 3 stimulus-response ensembles according to the taxonomy of [Kornblum, S., Stevens, G. (2002). Sequential effects of dimensional overlap: findings and issues. In: Prinz, W., Hommel., B. (Eds.), Common mechanism in perception and action. Oxford University Press, Oxford, pp. 9-54]) conflict resolution in both tasks results in the activation of different task-specific regions probably related to the different sources of task-irrelevant information. Furthermore, the present data give evidence those task-specific regions are most likely to detect the relationship between task-relevant and task-irrelevant information.

Temporal correlations between impulsive ultraviolet and hard X-ray bursts in solar flares observed with high time resolution

NASA Technical Reports Server (NTRS)

Cheng, Chung-Chieh; Vanderveen, K.; Orwig, L. E.; Tandberg-Hanssen, E.

1988-01-01

The impulsive phase of solar flares has been simultaneously observed in the ultraviolet O V line, the UV continuum, and hard X-rays with a time resolution of 0.128 s by the SMM satellite. A close time correspondence between the three impulsive components is found, with the best correlation being at the peak of the impulsive phase. Individual bursts or fast features in the O V and the UV continuum are shown to lag behind the corresponding hard X-ray features. None of the considered energy transport mechanisms (thermal conduction, a nonthermal electron beam, electron hole boring, UV radiation, and Alfven waves) are able to consistently account for the observed temporal correlations.

Satellite-based high-resolution mapping of rainfall over southern Africa

NASA Astrophysics Data System (ADS)

Meyer, Hanna; Drönner, Johannes; Nauss, Thomas

2017-06-01

A spatially explicit mapping of rainfall is necessary for southern Africa for eco-climatological studies or nowcasting but accurate estimates are still a challenging task. This study presents a method to estimate hourly rainfall based on data from the Meteosat Second Generation (MSG) Spinning Enhanced Visible and Infrared Imager (SEVIRI). Rainfall measurements from about 350 weather stations from 2010-2014 served as ground truth for calibration and validation. SEVIRI and weather station data were used to train neural networks that allowed the estimation of rainfall area and rainfall quantities over all times of the day. The results revealed that 60 % of recorded rainfall events were correctly classified by the model (probability of detection, POD). However, the false alarm ratio (FAR) was high (0.80), leading to a Heidke skill score (HSS) of 0.18. Estimated hourly rainfall quantities were estimated with an average hourly correlation of ρ = 0. 33 and a root mean square error (RMSE) of 0.72. The correlation increased with temporal aggregation to 0.52 (daily), 0.67 (weekly) and 0.71 (monthly). The main weakness was the overestimation of rainfall events. The model results were compared to the Integrated Multi-satellitE Retrievals for GPM (IMERG) of the Global Precipitation Measurement (GPM) mission. Despite being a comparably simple approach, the presented MSG-based rainfall retrieval outperformed GPM IMERG in terms of rainfall area detection: GPM IMERG had a considerably lower POD. The HSS was not significantly different compared to the MSG-based retrieval due to a lower FAR of GPM IMERG. There were no further significant differences between the MSG-based retrieval and GPM IMERG in terms of correlation with the observed rainfall quantities. The MSG-based retrieval, however, provides rainfall in a higher spatial resolution. Though estimating rainfall from satellite data remains challenging, especially at high temporal resolutions, this study showed promising results towards improved spatio-temporal estimates of rainfall over southern Africa.

Sedimentology and High Resolution Sequence Stratigraphy of the Middle Jurassic Dhruma Formation Carbonates Outcrops in the Central Saudi Arabia

NASA Astrophysics Data System (ADS)

Yousif, Ibrahim; Abdullatif, Osman; Makkawi, Mohammed; Abdulghani, Waleed

2017-04-01

This study investigates the microfacies and sequence stratigraphic frame work of the Middle Jurassic Dhruma Formation in outcrops in central Saudi Arabia. The study contributes to the efforts to understand and enhance local and regional stratigraphic relationship and correlation of the Jurassic carbonate sequences and their significance to reservoir description and prediction in the subsurcae. The study describes and characterizes the sedimentology, microfacies and the stratigraphy of Dhruma Formation from outcrop sections having a total thickness of 70 m. Detailed microfacies and high-resolution stratigraphical analysis were carried out to determine microfacies, cyclicity, sequences and staking pattern. The study revealed ten lithofacies namely: oolitic grainstone,bioclastic oolitic grainstone, oolitic grapestone, bioclastic grainstone,foraminiferal packstone, echinoderm packstone, peloidal packstone to grainstone,skeletal wackestone to packstone, mudstone, and marlstone.These lithofacies were grouped into five lithofacies associations that deposited on a carbonate ramp setting. The depositional environment ranging from low energy lagoonal setting to high-energy shoals and banks to low energy outer ramp setting. Five high-resolution composite sequences have been defined and each sequence is composed at the bottom of intercalated mudstone/wackestone that passing up into grainstone lithofacies.The composite sequences range in thickness from 7 to 15 m, while the parasequences range from 0.5 to 1.5 m. The composite sequences extend laterally for a distance of more than 350 m. The overall composite section shows a shallowing upward succession of the 4th to the 5th order high-resolution sequences.The dominant lithofacies are the grainy ones, which constitute 30%, 50% and 80% of the studied sections. Furthermore, the parasequences thickness and their bio-components are increasing towards the top. The muddy lithofacies intensively affected the vertical continuity of the lower reservoir interval compared to the upper interval. Detailed examination of thin-sections reflects a clear and well-developed reservoir interval in the uppermost part of the section, which is dominated by peloidal packstone and grainstone.The findings of this high-resolution outcrop analog might help to understand and predict lithofacies, stratigraphic heirachies and correlations of Dhruma Formation within the interwell spacing. Moreover, this study might also contribute to better reservoir description and assessment of its quality and architecture in subsurface equivalent reservoirs.

Adaptive windowing in contrast-enhanced intravascular ultrasound imaging

PubMed Central

Lindsey, Brooks D.; Martin, K. Heath; Jiang, Xiaoning; Dayton, Paul A.

2016-01-01

Intravascular ultrasound (IVUS) is one of the most commonly-used interventional imaging techniques and has seen recent innovations which attempt to characterize the risk posed by atherosclerotic plaques. One such development is the use of microbubble contrast agents to image vasa vasorum, fine vessels which supply oxygen and nutrients to the walls of coronary arteries and typically have diameters less than 200 µm. The degree of vasa vasorum neovascularization within plaques is positively correlated with plaque vulnerability. Having recently presented a prototype dual-frequency transducer for contrast agent-specific intravascular imaging, here we describe signal processing approaches based on minimum variance (MV) beamforming and the phase coherence factor (PCF) for improving the spatial resolution and contrast-to-tissue ratio (CTR) in IVUS imaging. These approaches are examined through simulations, phantom studies, ex vivo studies in porcine arteries, and in vivo studies in chicken embryos. In phantom studies, PCF processing improved CTR by a mean of 4.2 dB, while combined MV and PCF processing improved spatial resolution by 41.7%. Improvements of 2.2 dB in CTR and 37.2% in resolution were observed in vivo. Applying these processing strategies can enhance image quality in conventional B-mode IVUS or in contrast-enhanced IVUS, where signal-to-noise ratio is relatively low and resolution is at a premium. PMID:27161022

Higher curvature self-interaction corrections to Hawking radiation

NASA Astrophysics Data System (ADS)

Fairoos, C.; Sarkar, Sudipta; Yogendran, K. P.

2017-07-01

The purely thermal nature of Hawking radiation from evaporating black holes leads to the information loss paradox. A possible route to its resolution could be if (enough) correlations are shown to be present in the radiation emitted from evaporating black holes. A reanalysis of Hawking's derivation including the effects of self-interactions in general relativity shows that the emitted radiation does deviate from pure thermality; however no correlations exist between successively emitted Hawking quanta. We extend the calculations to Einstein-Gauss-Bonnet gravity and investigate if higher curvature corrections to the action lead to some new correlations in the Hawking spectra. The effective trajectory of a massless shell is determined by solving the constraint equations and the semiclassical tunneling probability is calculated. As in the case of general relativity, the radiation is no longer thermal and there is no correlation between successive emissions. The absence of any extra correlations in the emitted radiations even in Gauss-Bonnet gravity suggests that the resolution of the paradox is beyond the scope of semiclassical gravity.

Correlation of two-photon in vivo imaging and FIB/SEM microscopy

PubMed Central

Blazquez-Llorca, L; Hummel, E; Zimmerman, H; Zou, C; Burgold, S; Rietdorf, J; Herms, J

2015-01-01

Advances in the understanding of brain functions are closely linked to the technical developments in microscopy. In this study, we describe a correlative microscopy technique that offers a possibility of combining two-photon in vivo imaging with focus ion beam/scanning electron microscope (FIB/SEM) techniques. Long-term two-photon in vivo imaging allows the visualization of functional interactions within the brain of a living organism over the time, and therefore, is emerging as a new tool for studying the dynamics of neurodegenerative diseases, such as Alzheimer’s disease. However, light microscopy has important limitations in revealing alterations occurring at the synaptic level and when this is required, electron microscopy is mandatory. FIB/SEM microscopy is a novel tool for three-dimensional high-resolution reconstructions, since it acquires automated serial images at ultrastructural level. Using FIB/SEM imaging, we observed, at 10 nm isotropic resolution, the same dendrites that were imaged in vivo over 9 days. Thus, we analyzed their ultrastructure and monitored the dynamics of the neuropil around them. We found that stable spines (present during the 9 days of imaging) formed typical asymmetric contacts with axons, whereas transient spines (present only during one day of imaging) did not form a synaptic contact. Our data suggest that the morphological classification that was assigned to a dendritic spine according to the in vivo images did not fit with its ultrastructural morphology. The correlative technique described herein is likely to open opportunities for unravelling the earlier unrecognized complexity of the nervous system. Lay Description Neuroscience and the understanding of brain functions are closely linked to the technical advances in microscopy. In this study we performed a correlative microscopy technique that offers the possibility to combine 2 photon in vivo imaging and FIB/SEM microscopy. Long term 2 photon in vivo imaging allows the visualization of functional interactions within the brain of a living organism over the time, and therefore, is emerging as a new tool to study the dynamics of neurodegenerative diseases, such as Alzheimer’s disease. However, light microscopy has important limitations in revealing synapses that are the connections between neurons, and for this purpose, the electron microscopy is necessary. FIB/SEM microscopy is a novel tool for three-dimensional (3D) high resolution reconstructions since it acquires automated serial images at ultrastructural level. This correlative technique will open up new horizons and opportunities for unravelling the complexity of the nervous system. PMID:25786682

High resolution seismic reflection profiling at Aberdeen Proving Grounds, Maryland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, R.D.; Xia, Jianghai; Swartzel, S.

1996-11-01

The effectiveness of shallow high resolution seismic reflection (i.e., resolution potential) to image geologic interfaces between about 70 and 750 ft at the Aberdeen Proving Grounds, Maryland (APG), appears to vary locally with the geometric complexity of the unconsolidated sediments that overlay crystalline bedrock. The bedrock surface (which represents the primary geologic target of this study) was imaged at each of three test areas on walkaway noise tests and CDP (common depth point) stacked data. Proven high resolution techniques were used to design and acquire data on this survey. Feasibility of the technique and minimum acquisition requirements were determined throughmore » evaluation and correlation of walkaway noise tests, CDP survey lines, and a downhole velocity check shot survey. Data processing and analysis revealed several critical attributes of shallow seismic data from APG that need careful consideration and compensation on reflection data sets. This survey determined: (1) the feasibility of the technique, (2) the resolution potential (both horizontal and vertical) of the technique, (3) the optimum source for this site, (4) the optimum acquisition geometries, (5) general processing flow, and (6) a basic idea of the acoustic variability across this site. Source testing involved an accelerated weight drop, land air gun, downhole black powder charge, sledge hammer/plate, and high frequency vibrator. Shallow seismic reflection profiles provided for a more detailed picture of the geometric complexity and variability of the distinct clay sequences (aquatards), previously inferred from drilling to be present, based on sparse drill holes and basewide conceptual models. The seismic data also reveal a clear explanation for the difficulties previously noted in correlating individual, borehole-identified sand or clay units over even short distances.« less

Electromagnetically-induced-transparency intensity-correlation power broadening in a buffer gas

NASA Astrophysics Data System (ADS)

Zheng, Aojie; Green, Alaina; Crescimanno, Michael; O'Leary, Shannon

2016-04-01

Electromagnetically-induced-transparency (EIT) noise correlation spectroscopy holds promise as a simple, robust method for performing high-resolution spectroscopy used in optical magnetometry and clocks. Of relevance to these applications, we report on the role of buffer gas pressure and magnetic field gradients on power broadening of Zeeman-EIT noise correlation resonances.

Auto correlation analysis of coda waves from local earthquakes for detecting temporal changes in shallow subsurface structures - The 2011 Tohoku-Oki, Japan, earthquake -

NASA Astrophysics Data System (ADS)

Nakahara, H.

2013-12-01

For monitoring temporal changes in subsurface structures, I propose to use auto correlation functions of coda waves from local earthquakes recorded at surface receivers, which probably contain more body waves than surface waves. Because the use of coda waves requires earthquakes, time resolution for monitoring decreases. But at regions with high seismicity, it may be possible to monitor subsurface structures in sufficient time resolutions. Studying the 2011 Tohoku-Oki (Mw 9.0), Japan, earthquake for which velocity changes have been already reported by previous studies, I try to validate the method. KiK-net stations in northern Honshu are used in the analysis. For each moderate earthquake, normalized auto correlation functions of surface records are stacked with respect to time windows in S-wave coda. Aligning the stacked normalized auto correlation functions with time, I search for changes in arrival times of phases. The phases at lag times of less than 1s are studied because changes at shallow depths are focused. Based on the stretching method, temporal variations in the arrival times are measured at the stations. Clear phase delays are found to be associated with the mainshock and to gradually recover with time. Amounts of the phase delays are in the order of 10% on average with the maximum of about 50% at some stations. For validation, the deconvolution analysis using surface and subsurface records at the same stations are conducted. The results show that the phase delays from the deconvolution analysis are slightly smaller than those from the auto correlation analysis, which implies that the phases on the auto correlations are caused by larger velocity changes at shallower depths. The auto correlation analysis seems to have an accuracy of about several percents, which is much larger than methods using earthquake doublets and borehole array data. So this analysis might be applicable to detect larger changes. In spite of these disadvantages, this analysis is still attractive because it can be applied to many records on the surface in regions where no boreholes are available. Acknowledgements: Seismograms recorded by KiK-net managed by National Research Institute for Earth Science and Disaster Prevention (NIED) were used in this study. This study was partially supported by JST J-RAPID program and JSPS KAKENHI Grant Numbers 24540449 and 23540449.

Search for correlations between the arrival directions of IceCube neutrino events and ultrahigh-energy cosmic rays detected by the Pierre Auger Observatory and the Telescope Array

DOE PAGES

Aartsen, M. G.

2016-01-20

This study presents the results of different searches for correlations between very high-energy neutrino candidates detected by IceCube and the highest-energy cosmic rays measured by the Pierre Auger Observatory and the Telescope Array. We first consider samples of cascade neutrino events and of high-energy neutrino-induced muon tracks, which provided evidence for a neutrino flux of astrophysical origin, and study their cross-correlation with the ultrahigh-energy cosmic ray (UHECR) samples as a function of angular separation. We also study their possible directional correlations using a likelihood method stacking the neutrino arrival directions and adopting different assumptions on the size of the UHECRmore » magnetic deflections. Finally, we perform another likelihood analysis stacking the UHECR directions and using a sample of through-going muon tracks optimized for neutrino point-source searches with sub-degree angular resolution. No indications of correlations at discovery level are obtained for any of the searches performed. The smallest of the p-values comes from the search for correlation between UHECRs with IceCube high-energy cascades, a result that should continue to be monitored.« less

Compressive light field imaging

NASA Astrophysics Data System (ADS)

Ashok, Amit; Neifeld, Mark A.

2010-04-01

Light field imagers such as the plenoptic and the integral imagers inherently measure projections of the four dimensional (4D) light field scalar function onto a two dimensional sensor and therefore, suffer from a spatial vs. angular resolution trade-off. Programmable light field imagers, proposed recently, overcome this spatioangular resolution trade-off and allow high-resolution capture of the (4D) light field function with multiple measurements at the cost of a longer exposure time. However, these light field imagers do not exploit the spatio-angular correlations inherent in the light fields of natural scenes and thus result in photon-inefficient measurements. Here, we describe two architectures for compressive light field imaging that require relatively few photon-efficient measurements to obtain a high-resolution estimate of the light field while reducing the overall exposure time. Our simulation study shows that, compressive light field imagers using the principal component (PC) measurement basis require four times fewer measurements and three times shorter exposure time compared to a conventional light field imager in order to achieve an equivalent light field reconstruction quality.

Spatial resolution enhancement of terrestrial features using deconvolved SSM/I microwave brightness temperatures

NASA Technical Reports Server (NTRS)

Farrar, Michael R.; Smith, Eric A.

1992-01-01

A method for enhancing the 19, 22, and 37 GHz measurements of the SSM/I (Special Sensor Microwave/Imager) to the spatial resolution and sampling density of the high resolution 85-GHz channel is presented. An objective technique for specifying the tuning parameter, which balances the tradeoff between resolution and noise, is developed in terms of maximizing cross-channel correlations. Various validation procedures are performed to demonstrate the effectiveness of the method, which hopefully will provide researchers with a valuable tool in multispectral applications of satellite radiometer data.

Correlative FRET: new method improves rigor and reproducibility in determining distances within synaptic nanoscale architecture

NASA Astrophysics Data System (ADS)

Shinogle-Decker, Heather; Martinez-Rivera, Noraida; O'Brien, John; Powell, Richard D.; Joshi, Vishwas N.; Connell, Samuel; Rosa-Molinar, Eduardo

2018-02-01

A new correlative Förster Resonance Energy Transfer (FRET) microscopy method using FluoroNanogold™, a fluorescent immunoprobe with a covalently attached Nanogold® particle (1.4nm Au), overcomes resolution limitations in determining distances within synaptic nanoscale architecture. FRET by acceptor photobleaching has long been used as a method to increase fluorescence resolution. The transfer of energy from a donor to an acceptor generally occurs between 10-100Å, which is the relative distance between the donor molecule and the acceptor molecule. For the correlative FRET microscopy method using FluoroNanogold™, we immuno-labeled GFP-tagged-HeLa-expressing Connexin 35 (Cx35) with anti-GFP and with anti-Cx35/36 antibodies, and then photo-bleached the Cx before processing the sample for electron microscopic imaging. Preliminary studies reveal the use of Alexa Fluor® 594 FluoroNanogold™ slightly increases FRET distance to 70Å, in contrast to the 62.5Å using AlexaFluor 594®. Preliminary studies also show that using a FluoroNanogold™ probe inhibits photobleaching. After one photobleaching session, Alexa Fluor 594® fluorescence dropped to 19% of its original fluorescence; in contrast, after one photobleaching session, Alexa Fluor 594® FluoroNanogold™ fluorescence dropped to 53% of its original intensity. This result confirms that Alexa Fluor 594® FluoroNanogold™ is a much better donor probe than is Alexa Fluor 594®. The new method (a) creates a double confirmation method in determining structure and orientation of synaptic architecture, (b) allows development of a two-dimensional in vitro model to be used for precise testing of multiple parameters, and (c) increases throughput. Future work will include development of FluoroNanogold™ probes with different sizes of gold for additional correlative microscopy studies.

Thinner regions of intracranial aneurysm wall correlate with regions of higher wall shear stress: a 7.0 tesla MRI

PubMed Central

Blankena, Roos; Kleinloog, Rachel; Verweij, Bon H.; van Ooij, Pim; ten Haken, Bennie; Luijten, Peter R.; Rinkel, Gabriel J.E.; Zwanenburg, Jaco J.M.

2016-01-01

Purpose To develop a method for semi-quantitative wall thickness assessment on in vivo 7.0 tesla (7T) MRI images of intracranial aneurysms for studying the relation between apparent aneurysm wall thickness and wall shear stress. Materials and Methods Wall thickness was analyzed in 11 unruptured aneurysms in 9 patients, who underwent 7T MRI with a TSE based vessel wall sequence (0.8 mm isotropic resolution). A custom analysis program determined the in vivo aneurysm wall intensities, which were normalized to signal of nearby brain tissue and were used as measure for apparent wall thickness (AWT). Spatial wall thickness variation was determined as the interquartile range in AWT (the middle 50% of the AWT range). Wall shear stress was determined using phase contrast MRI (0.5 mm isotropic resolution). We performed visual and statistical comparisons (Pearson’s correlation) to study the relation between wall thickness and wall shear stress. Results 3D colored AWT maps of the aneurysms showed spatial AWT variation, which ranged from 0.07 to 0.53, with a mean variation of 0.22 (a variation of 1.0 roughly means a wall thickness variation of one voxel (0.8mm)). In all aneurysms, AWT was inversely related to WSS (mean correlation coefficient −0.35, P<0.05). Conclusions A method was developed to measure the wall thickness semi-quantitatively, using 7T MRI. An inverse correlation between wall shear stress and AWT was determined. In future studies, this non-invasive method can be used to assess spatial wall thickness variation in relation to pathophysiologic processes such as aneurysm growth and –rupture. PMID:26892986

Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

NASA Astrophysics Data System (ADS)

Zhou, Xin; Ju, Myeong Jin; Huang, Lin; Tang, Shuo

2017-02-01

Polarization-sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are two imaging modalities with different resolutions, field-of-views (FOV), and contrasts, while they both have the capability of imaging collagen fibers in biological tissues. PS-OCT can measure the tissue birefringence which is induced by highly organized fibers while SHG can image the collagen fiber organization with high resolution. Articular cartilage, with abundant structural collagen fibers, is a suitable sample to study the correlation between PS-OCT and SHG microscopy. Qualitative conjecture has been made that the phase retardation measured by PS-OCT is affected by the relationship between the collagen fiber orientation and the illumination direction. Anatomical studies show that the multilayered architecture of articular cartilage can be divided into four zones from its natural surface to the subchondral bone: the superficial zone, the middle zone, the deep zone, and the calcified zone. The different zones have different collagen fiber orientations, which can be studied by the different slopes in the cumulative phase retardation in PS-OCT. An algorithm is developed based on the quantitative analysis of PS-OCT phase retardation images to analyze the microstructural features in swine articular cartilage tissues. This algorithm utilizes the depth-dependent slope changing of phase retardation A-lines to segment structural layers. The results show good consistency with the knowledge of cartilage morphology and correlation with the SHG images measured at selected depth locations. The correlation between PS-OCT and SHG microscopy shows that PS-OCT has the potential to analyze both the macro and micro characteristics of biological tissues with abundant collagen fibers and other materials that may cause birefringence.

Hypopigmented mycosis fungoides: a retrospective clinicohistopathologic study.

PubMed

Rodney, I J; Kindred, C; Angra, K; Qutub, O N; Villanueva, A R; Halder, R M

2017-05-01

Hypopigmented mycosis fungoides is a rare variant of mycosis fungoides with limited published clinicohistopathologic data available. To characterize our patient group, to provide additional information and insight into this malignancy. A 16-year retrospective medical records review (from 1992 to 2009) was conducted of patients with a diagnosis of hypopigmented mycosis fungoides. All patients were seen in the department of dermatology at Howard University Hospital, an outpatient clinic in an urban academic institution. The review comprised of 20 patients. Inclusion required presence of hypopigmented skin lesions and a skin biopsy diagnostic for hypopigmented mycosis fungoides. Treatment modalities, including oral psoralen with UVA, narrow-band UVB and/or topical medications such as nitrogen mustard and topical corticosteroids were employed. Patients ranged from 4 to 57 years old. Fifteen were African American, three African, one Afro-Caribbean and one Hispanic. The interval from disease onset to diagnosis ranged from 7 months to 24 years. Patients presented at Stage 1A or 1B. Treatment included phototherapy and topical medications. In four patients with pre- and post-treatment biopsies, the original histological diagnosis of hypopigmented mycosis fungoides and the subsequent complete resolution were shown. There was no associated mortality in the patients studied. Hypopigmented mycosis fungoides affected skin of colour patients in this study. This variant differs from classic mycosis fungoides: younger population, slower progression and the majority of patients remaining in Stage I with treatment. We observed that any repigmentation of lesions suggests an effective treatment regimen, complete repigmentation correlates with clinical and histopathologic resolution, and new hypopigmented lesions during remission suggest relapse. A limitation of this study is the small sample size. This is the first study to correlate the histological resolution of hypopigmented mycosis fungoides with clinical repigmentation of lesions. © 2016 European Academy of Dermatology and Venereology.

High Resolution Aerosol Data from MODIS Satellite for Urban Air Quality Studies

NASA Technical Reports Server (NTRS)

Chudnovsky, A.; Lyapustin, A.; Wang, Y.; Tang, C.; Schwartz, J.; Koutrakis, P.

2013-01-01

The Moderate Resolution Imaging Spectroradiometer (MODIS) provides daily global coverage, but the 10 km resolution of its aerosol optical depth (AOD) product is not suitable for studying spatial variability of aerosols in urban areas. Recently, a new Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm was developed for MODIS which provides AOD at 1 km resolution. Using MAIAC data, the relationship between MAIAC AOD and PM(sub 2.5) as measured by the 27 EPA ground monitoring stations was investigated. These results were also compared to conventional MODIS 10 km AOD retrievals (MOD04) for the same days and locations. The coefficients of determination for MOD04 and for MAIAC are R(exp 2) =0.45 and 0.50 respectively, suggested that AOD is a reasonably good proxy for PM(sub 2.5) ground concentrations. Finally, we studied the relationship between PM(sub 2.5) and AOD at the intra-urban scale (10 km) in Boston. The fine resolution results indicated spatial variability in particle concentration at a sub-10 kilometer scale. A local analysis for the Boston area showed that the AOD-PM(sub 2.5) relationship does not depend on relative humidity and air temperatures below approximately 7 C. The correlation improves for temperatures above 7 - 16 C. We found no dependence on the boundary layer height except when the former was in the range 250-500 m. Finally, we apply a mixed effects model approach to MAIAC aerosol optical depth (AOD) retrievals from MODIS to predict PM(sub 2.5) concentrations within the greater Boston area. With this approach we can control for the inherent day-to-day variability in the AOD-PM(sub 2.5) relationship, which depends on time-varying parameters such as particle optical properties, vertical and diurnal concentration profiles and ground surface reflectance. Our results show that the model-predicted PM(sub 2.5) mass concentrations are highly correlated with the actual observations (out-of-sample R(exp 2) of 0.86). Therefore, adjustment for the daily variability in the AOD-PM(sub 2.5) relationship provides a means for obtaining spatially-resolved PM(sub 2.5) concentrations.

Carbon and nitrogen abundances in metal-poor dwarfs of the solar neighborhood

NASA Technical Reports Server (NTRS)

Carbon, Duane F.; Barbuy, Beatrice; Kraft, Robert P.; Friel, Eileen D.; Suntzeff, Nicholas B.

1987-01-01

Intermediate-resolution C, N, and Fe abundance spectra for 83 subdwarfs in the lowest metallicity range (-1.5 to -3.2), obtained with the Lick Observatory 3.1-m Shane telescope, are analyzed. The effects of subgiants and binaries on the sample are examined. The relation between (B-V) and (V-K) and effective temperature is studied. C/Fe, N/Fe, and Fe/H abundances were determined using the model-atmosphere technique of spectrum synthesis. The derived abundance values are compared with data from previous investigations. It is observed that there is good correlation between the Fe/H abundance values derived from the intermediate-resolution spectra and those based on high-resolution spectra; C/Fe abundance values are constant; and there is an upturn in the C/Fe abundance values at the very lowest metallicities.

High resolution, low h{nu} photoelectron spectroscopy with the use of a microwave excited rare gas lamp and ionic crystal filters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suga, S.; Sekiyama, A.; Funabashi, G.

2010-10-15

The need for not only bulk sensitive but also extremely high resolution photoelectron spectroscopy for studying detailed electronic structures of strongly correlated electron systems is growing rapidly. Moreover, easy access to such a capability in one's own laboratory is desirable. Demonstrated here is the performance of a microwave excited rare gas (Xe, Kr, and Ar) lamp combined with ionic crystal filters (sapphire, CaF{sub 2}, and LiF), which can supply three strong lines near the photon energy of hnyu h{nu}=8.4, 10.0, and 11.6 eV, with the h{nu} resolution of better than 600 {mu}eV for photoelectron spectroscopy. Its performance is demonstrated onmore » some materials by means of both angle-integrated and angle-resolved measurements.« less

Quantitative validation of a nonlinear histology-MRI coregistration method using Generalized Q-sampling Imaging in complex human cortical white matter

PubMed Central

Gangolli, Mihika; Holleran, Laurena; Kim, Joong Hee; Stein, Thor D.; Alvarez, Victor; McKee, Ann C.; Brody, David L.

2017-01-01

Advanced diffusion MRI methods have recently been proposed for detection of pathologies such as traumatic axonal injury and chronic traumatic encephalopathy which commonly affect complex cortical brain regions. However, radiological-pathological correlations in human brain tissue that detail the relationship between the multi-component diffusion signal and underlying pathology are lacking. We present a nonlinear voxel based two dimensional coregistration method that is useful for matching diffusion signals to quantitative metrics of high resolution histological images. When validated in ex vivo human cortical tissue at a 250 × 250 × 500 micron spatial resolution, the method proved robust in correlations between generalized q-sampling imaging and histologically based white matter fiber orientations, with r = 0.94 for the primary fiber direction and r = 0.88 for secondary fiber direction in each voxel. Importantly, however, the correlation was substantially worse with reduced spatial resolution or with fiber orientations derived using a diffusion tensor model. Furthermore, we have detailed a quantitative histological metric of white matter fiber integrity termed power coherence capable of distinguishing between architecturally complex but intact white matter from disrupted white matter regions. These methods may allow for more sensitive and specific radiological-pathological correlations of neurodegenerative diseases affecting complex gray and white matter. PMID:28365421

Wall enhancement on high-resolution magnetic resonance imaging may predict an unsteady state of an intracranial saccular aneurysm.

PubMed

Hu, Peng; Yang, Qi; Wang, Dan-Dan; Guan, Shao-Chen; Zhang, Hong-Qi

2016-10-01

The aneurysm wall has been reported to play a critical role in the formation, development, and even rupture of an aneurysm. We used high-resolution magnetic resonance imaging (HRMRI) to investigate the aneurysm wall in an effort to identify evidence of inflammation invasion and define its relationship with aneurysm behavior. Patients with intracranial aneurysms who were prospectively evaluated using HRMRI between July 2013 and June 2014 were enrolled in this study. The aneurysm's wall enhancement and evidence of inflammation invasion were determined. In addition, the relationship between aneurysm wall enhancement and aneurysm size and symptoms, including ruptured aneurysms, giant unruputred intracranial aneurysms (UIAs) presenting as mass effect, progressively growing aneurysms, and aneurysms associated with neurological symptoms, was statistically analyzed. Twenty-five patients with 30 aneurysms were available for the current study. Fourteen aneurysms showed wall enhancement, including 6 ruptured and 8 unruptured aneurysms. Evidence of inflammation was identified directly through histological studies and indirectly through intraoperative investigations and clinical courses. The statistical analysis indicated no significant correlation between aneurysm wall enhancement and aneurysm size. However, there was a strong correlation between wall enhancement and aneurysm symptoms, with a kappa value of 0.86 (95 % CI 0.68-1). Aneurysm wall enhancement on HRMRI might be a sign of inflammatory change. Symptomatic aneurysms exhibited wall enhancement on HRMRI. Wall enhancement had a high consistent correlation of symptomatic aneurysms. Therefore, wall enhancement on HRMRI might predict an unsteady state of an intracranial saccular aneurysm.

Inducing fluorescence of uranyl acetate as a dual-purpose contrast agent for correlative light-electron microscopy with nanometre precision.

PubMed

Tuijtel, Maarten W; Mulder, Aat A; Posthuma, Clara C; van der Hoeven, Barbara; Koster, Abraham J; Bárcena, Montserrat; Faas, Frank G A; Sharp, Thomas H

2017-09-05

Correlative light-electron microscopy (CLEM) combines the high spatial resolution of transmission electron microscopy (TEM) with the capability of fluorescence light microscopy (FLM) to locate rare or transient cellular events within a large field of view. CLEM is therefore a powerful technique to study cellular processes. Aligning images derived from both imaging modalities is a prerequisite to correlate the two microscopy data sets, and poor alignment can limit interpretability of the data. Here, we describe how uranyl acetate, a commonly-used contrast agent for TEM, can be induced to fluoresce brightly at cryogenic temperatures (-195 °C) and imaged by cryoFLM using standard filter sets. This dual-purpose contrast agent can be used as a general tool for CLEM, whereby the equivalent staining allows direct correlation between fluorescence and TEM images. We demonstrate the potential of this approach by performing multi-colour CLEM of cells containing equine arteritis virus proteins tagged with either green- or red-fluorescent protein, and achieve high-precision localization of virus-induced intracellular membrane modifications. Using uranyl acetate as a dual-purpose contrast agent, we achieve an image alignment precision of ~30 nm, twice as accurate as when using fiducial beads, which will be essential for combining TEM with the evolving field of super-resolution light microscopy.

Characterization of intermittency and statistical properties of high-resolution rainfall observations across a topographic transect in Northwest Mexico

NASA Astrophysics Data System (ADS)

Mascaro, G.; Vivoni, E. R.; Gochis, D. J.; Watts, C. J.; Rodriguez, J. C.

2013-12-01

In northwest Mexico, the statistical properties of rainfall at high temporal resolution (up to 1 min) have been poorly characterized, mainly due to a lack of observations. Under a combined effort of US and Mexican institutions initiated during the North American Monsoon-Soil Moisture Experiment in 2004 (NAME-SMEX04), a network of 8 tipping-bucket rain gauges were installed across a topographic transect in the Sierra Los Locos basin of Sonora, Mexico. The transect spans a distance of ~14 km and an elevation difference of 748 m, thus including valley, mid-elevation and ridge sites where rainfall generation mechanisms in the summer and winter seasons are potentially affected by orography. In this study, we used the data collected during the period of 2007-2010 to characterize the rainfall statistical properties in a wide range of time scales (1 min to ~45 days) and analyzed how these properties change as a function of elevation, the gauge separation distance, and the summer and winter seasons. We found that the total summer (winter) rainfall decreases (increases) with elevation, and that rainfall has a clear diurnal cycle in the summertime, with a peak around 9 pm at all gauges. The correlation structure across the transect indicates that: (i) when times series are aggregated at a resolution greater than 3 hours, the correlation distance is greater than the maximum separation distance (~14 km), while it dramatically decreases for lower time resolutions (e.g., it is ~1.5 km when the resolution is 10 min). Consistent with other semiarid regions, spectral and scale invariance analyses show the presence of different scaling regimes, which are associated to single convective events and larger stratiform systems, with different intermittency properties dependent on the rainfall season. Results of this work are useful for the interpretation of storm generation mechanisms and hydrologic response in the region, as well as for the calibration of high-resolution, stochastic rainfall models used in climate, hydrology, and engineering applications.

Spatial and temporal trends of mercury and other metals in landlocked char from lakes in the Canadian Arctic archipelago.

PubMed

Muir, Derek; Wang, Xiaowa; Bright, Doug; Lockhart, Lyle; Köck, Günter

2005-12-01

Spatial and temporal trends of mercury (Hg) and 22 other elements were examined in landlocked Arctic char (Salvelinus alpinus) from six lakes in the Canadian Arctic (Char, Resolute and North Lakes, and Amituk Lake on Cornwallis Island, Sapphire Lake on Devon Island and Boomerang Lake on Somerset Island). The objectives of the study were to compare recent concentrations of Hg and other metals in char with older data from Amituk, Resolute and Char Lakes, in order to examine temporal trends as well as to investigate factors influencing spatial trends in contaminant levels such as lake characteristics, trophic position, size and age of the fish. Geometric mean Hg concentrations in dorsal muscle ranged from 0.147 microg/g wet weight (ww) in Resolute Lake to 1.52 microg/g ww in Amituk Lake for samples collected over the period 1999-2003. Char from Amituk Lake also had significantly higher selenium (Se). Mercury in char from Resolute Lake was strongly correlated with fish length, weight, and age, as well as with thallium, lead and Se. In 5 of 6 lakes, Hg concentrations were correlated with stable nitrogen isotope ratios (delta15N) and larger char were feeding at a higher trophic level presumably due to feeding on smaller char. Weight adjusted mean Hg concentrations in char from Amituk Lake, and unadjusted geometric means in Char Lake and Resolute Lakes, did not show any statistically significant increase from the early 1990s to 2003. However, small sample sizes from 1999-2003 for fish <1000 g limited the power of this comparison in Char and Amituk Lakes. In Resolute Lake char, manganese, strontium and zinc showed consistent decreases from 1997 or 1999 to 2003 while nickel generally increased over the 6 year period. Differences in char trophic level inferred from delta15N values best explained the higher concentrations of Hg in Amituk Lake compared to the other lakes.

Comparative Geostatistical Analysis of Flowmeter and Direct-Push Hydraulic Conductivity Profiles at the MADE Site

NASA Astrophysics Data System (ADS)

Bohling, G.; Liu, G.; Knobbe, S. J.; Reboulet, E. C.; Hyndman, D. W.; Dietrich, P.; Butler, J. J.

2010-12-01

Spatial variations in hydraulic conductivity (K) are a critical control on subsurface solute transport. Characterization of such variations at the resolution (cm to dm) required for transport investigations, however, has proven to be a formidable challenge. A new generation of direct-push (DP) tools has now been developed for the characterization of vertical K variations at this resolution. These tools, which can be run in high- (0.015-m) and low- (0.4 m) resolution modes, were recently applied to the extensively studied and highly heterogeneous MADE site. Results from a geostatistical analysis of 64 DP K profiles compare favorably with the flowmeter K data that have served as the primary basis for previous MADE studies. The global statistics of the low-resolution DP and flowmeter K data are in excellent agreement. The correlation structures for the high-resolution DP data show excellent agreement with those computed from the flowmeter data. However, the geometric mean DP K value for high-resolution profiling is roughly one order of magnitude lower than the geometric mean flowmeter K value, possibly as a result of the biases inherent in each approach compounded with differences in the areal distribution of flowmeter and DP profile locations. A DP profile through the MADE aquifer to a depth of 12 m can be completed as rapidly as 1.5-2 hours, a small fraction of the time required to obtain a single flowmeter profile when well drilling, installation, and development are considered. The results of this study demonstrate that DP profiling is a practically feasible approach for characterization of spatial variations in K at the resolution required for transport investigations in highly heterogeneous systems.

Solid-state NMR covariance of homonuclear correlation spectra.

PubMed

Hu, Bingwen; Amoureux, Jean-Paul; Trebosc, Julien; Deschamps, Michael; Tricot, Gregory

2008-04-07

Direct covariance NMR spectroscopy, which does not involve a Fourier transformation along the indirect dimension, is demonstrated to obtain homonuclear correlation two-dimensional (2D) spectra in the solid state. In contrast to the usual 2D Fourier transform (2D-FT) NMR, in a 2D covariance (2D-Cov) spectrum the spectral resolution in the indirect dimension is determined by the resolution along the detection dimension, thereby largely reducing the time-consuming indirect sampling requirement. The covariance method does not need any separate phase correction or apodization along the indirect dimension because it uses those applied in the detection dimension. We compare in detail the specifications obtained with 2D-FT and 2D-Cov, for narrow and broad resonances. The efficiency of the covariance data treatment is demonstrated in organic and inorganic samples that are both well crystallized and amorphous, for spin -1/2 nuclei with 13C, 29Si, and 31P through-space or through-bond homonuclear 2D correlation spectra. In all cases, the experimental time has been reduced by at least a factor of 10, without any loss of resolution and signal to noise ratio, with respect to what is necessary with the 2D-FT NMR. According to this method, we have been able to study the silicate network of glasses by 2D NMR within reasonable experimental time despite the very long relaxation time of the 29Si nucleus. The main limitation of the 2D-Cov data treatment is related to the introduction of autocorrelated peaks onto the diagonal, which does not represent any actual connectivity.

Evaluation of magnetic nanoparticle samples made from biocompatible ferucarbotran by time-correlation magnetic particle imaging reconstruction method

PubMed Central

2013-01-01

Background Molecular imaging using magnetic nanoparticles (MNPs)—magnetic particle imaging (MPI)—has attracted interest for the early diagnosis of cancer and cardiovascular disease. However, because a steep local magnetic field distribution is required to obtain a defined image, sophisticated hardware is required. Therefore, it is desirable to realize excellent image quality even with low-performance hardware. In this study, the spatial resolution of MPI was evaluated using an image reconstruction method based on the correlation information of the magnetization signal in a time domain and by applying MNP samples made from biocompatible ferucarbotran that have adjusted particle diameters. Methods The magnetization characteristics and particle diameters of four types of MNP samples made from ferucarbotran were evaluated. A numerical analysis based on our proposed method that calculates the image intensity from correlation information between the magnetization signal generated from MNPs and the system function was attempted, and the obtained image quality was compared with that using the prototype in terms of image resolution and image artifacts. Results MNP samples obtained by adjusting ferucarbotran showed superior properties to conventional ferucarbotran samples, and numerical analysis showed that the same image quality could be obtained using a gradient magnetic field generator with 0.6 times the performance. However, because image blurring was included theoretically by the proposed method, an algorithm will be required to improve performance. Conclusions MNP samples obtained by adjusting ferucarbotran showed magnetizing properties superior to conventional ferucarbotran samples, and by using such samples, comparable image quality (spatial resolution) could be obtained with a lower gradient magnetic field intensity. PMID:23734917

A Highly Accurate Face Recognition System Using Filtering Correlation

NASA Astrophysics Data System (ADS)

Watanabe, Eriko; Ishikawa, Sayuri; Kodate, Kashiko

2007-09-01

The authors previously constructed a highly accurate fast face recognition optical correlator (FARCO) [E. Watanabe and K. Kodate: Opt. Rev. 12 (2005) 460], and subsequently developed an improved, super high-speed FARCO (S-FARCO), which is able to process several hundred thousand frames per second. The principal advantage of our new system is its wide applicability to any correlation scheme. Three different configurations were proposed, each depending on correlation speed. This paper describes and evaluates a software correlation filter. The face recognition function proved highly accurate, seeing that a low-resolution facial image size (64 × 64 pixels) has been successfully implemented. An operation speed of less than 10 ms was achieved using a personal computer with a central processing unit (CPU) of 3 GHz and 2 GB memory. When we applied the software correlation filter to a high-security cellular phone face recognition system, experiments on 30 female students over a period of three months yielded low error rates: 0% false acceptance rate and 2% false rejection rate. Therefore, the filtering correlation works effectively when applied to low resolution images such as web-based images or faces captured by a monitoring camera.

A High-Resolution Demodulation Algorithm for FBG-FP Static-Strain Sensors Based on the Hilbert Transform and Cross Third-Order Cumulant

PubMed Central

Huang, Wenzhu; Zhen, Tengkun; Zhang, Wentao; Zhang, Fusheng; Li, Fang

2015-01-01

Static strain can be detected by measuring a cross-correlation of reflection spectra from two fiber Bragg gratings (FBGs). However, the static-strain measurement resolution is limited by the dominant Gaussian noise source when using this traditional method. This paper presents a novel static-strain demodulation algorithm for FBG-based Fabry-Perot interferometers (FBG-FPs). The Hilbert transform is proposed for changing the Gaussian distribution of the two FBG-FPs’ reflection spectra, and a cross third-order cumulant is used to use the results of the Hilbert transform and get a group of noise-vanished signals which can be used to accurately calculate the wavelength difference of the two FBG-FPs. The benefit by these processes is that Gaussian noise in the spectra can be suppressed completely in theory and a higher resolution can be reached. In order to verify the precision and flexibility of this algorithm, a detailed theory model and a simulation analysis are given, and an experiment is implemented. As a result, a static-strain resolution of 0.9 nε under laboratory environment condition is achieved, showing a higher resolution than the traditional cross-correlation method. PMID:25923938

A High-Resolution Demodulation Algorithm for FBG-FP Static-Strain Sensors Based on the Hilbert Transform and Cross Third-Order Cumulant.

PubMed

Huang, Wenzhu; Zhen, Tengkun; Zhang, Wentao; Zhang, Fusheng; Li, Fang

2015-04-27

Static strain can be detected by measuring a cross-correlation of reflection spectra from two fiber Bragg gratings (FBGs). However, the static-strain measurement resolution is limited by the dominant Gaussian noise source when using this traditional method. This paper presents a novel static-strain demodulation algorithm for FBG-based Fabry-Perot interferometers (FBG-FPs). The Hilbert transform is proposed for changing the Gaussian distribution of the two FBG-FPs' reflection spectra, and a cross third-order cumulant is used to use the results of the Hilbert transform and get a group of noise-vanished signals which can be used to accurately calculate the wavelength difference of the two FBG-FPs. The benefit by these processes is that Gaussian noise in the spectra can be suppressed completely in theory and a higher resolution can be reached. In order to verify the precision and flexibility of this algorithm, a detailed theory model and a simulation analysis are given, and an experiment is implemented. As a result, a static-strain resolution of 0.9 nε under laboratory environment condition is achieved, showing a higher resolution than the traditional cross-correlation method.

In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI.

PubMed

Bianciardi, Marta; Toschi, Nicola; Eichner, Cornelius; Polimeni, Jonathan R; Setsompop, Kawin; Brown, Emery N; Hämäläinen, Matti S; Rosen, Bruce R; Wald, Lawrence L

2016-06-01

Our aim was to map the in vivo human functional connectivity of several brainstem nuclei with the rest of the brain by using seed-based correlation of ultra-high magnetic field functional magnetic resonance imaging (fMRI) data. We used the recently developed template of 11 brainstem nuclei derived from multi-contrast structural MRI at 7 Tesla as seed regions to determine their connectivity to the rest of the brain. To achieve this, we used the increased contrast-to-noise ratio of 7-Tesla fMRI compared with 3 Tesla and time-efficient simultaneous multi-slice imaging to cover the brain with high spatial resolution (1.1-mm isotropic nominal resolution) while maintaining a short repetition time (2.5 s). The delineated Pearson's correlation-based functional connectivity diagrams (connectomes) of 11 brainstem nuclei of the ascending arousal, motor, and autonomic systems from 12 controls are presented and discussed in the context of existing histology and animal work. Considering that the investigated brainstem nuclei play a crucial role in several vital functions, the delineated preliminary connectomes might prove useful for future in vivo research and clinical studies of human brainstem function and pathology, including disorders of consciousness, sleep disorders, autonomic disorders, Parkinson's disease, and other motor disorders.

Positive weighing of the other's collective narrative among Jewish and Bedouin-Palestinian teachers in Israel and its correlates.

PubMed

Lazar, Alon; Braun-Lewensohn, Orna; Litvak Hirsch, Tal

2016-06-01

Teachers play a pivotal role in the educational discourse around collective narratives, and especially the other's narrative. The study assumed that members of groups entangled in a conflict approach the different modules of the other's narrative distinctively. Jewish and Palestinian teachers, Israeli citizens, answered questionnaires dealing with the narrative of the other, readiness for interethnic contact, negative between-group emotions and preferences for resolutions of the Israeli-Palestinian (I-P) conflict. Positive weighing of the other's narrative among Jewish teachers correlated with high levels of readiness for interethnic contact and low levels of negative between-group emotions, across the various modules of the Palestinian narrative. Preferences for a peaceful resolution of the I-P conflict and rejection of a violent one were noted in two of the modules. Among Palestinian teachers, positive weighing of the other's collective narrative was exclusively noted for the Israeli narrative of the Holocaust, and this stance negatively related to negative between-group emotions and preference for a violent solution of the I-P conflict, and positively related to readiness for interethnic contact and preference of a peaceful resolution of the conflict. Practical implications of these findings for peace education are discussed. © 2015 International Union of Psychological Science.

The 1.3 A resolution structure of the RNA tridecamer r(GCGUUUGAAACGC): metal ion binding correlates with base unstacking and groove contraction.

PubMed

Timsit, Youri; Bombard, Sophie

2007-12-01

Metal ions play a key role in RNA folding and activity. Elucidating the rules that govern the binding of metal ions is therefore an essential step for better understanding the RNA functions. High-resolution data are a prerequisite for a detailed structural analysis of ion binding on RNA and, in particular, the observation of monovalent cations. Here, the high-resolution crystal structures of the tridecamer duplex r(GCGUUUGAAACGC) crystallized under different conditions provides new structural insights on ion binding on GAAA/UUU sequences that exhibit both unusual structural and functional properties in RNA. The present study extends the repertory of RNA ion binding sites in showing that the two first bases of UUU triplets constitute a specific site for sodium ions. A striking asymmetric pattern of metal ion binding in the two equivalent halves of the palindromic sequence demonstrates that sequence and its environment act together to bind metal ions. A highly ionophilic half that binds six metal ions allows, for the first time, the observation of a disodium cluster in RNA. The comparison of the equivalent halves of the duplex provides experimental evidences that ion binding correlates with structural alterations and groove contraction.

A STED-FLIM microscope applied to imaging the natural killer cell immune synapse

NASA Astrophysics Data System (ADS)

Lenz, M. O.; Brown, A. C. N.; Auksorius, E.; Davis, D. M.; Dunsby, C.; Neil, M. A. A.; French, P. M. W.

2011-03-01

We present a stimulated emission depletion (STED) fluorescence lifetime imaging (FLIM) microscope, excited by a microstructured optical fibre supercontinuum source that is pumped by a femtosecond Ti:Sapphire-laser, which is also used for depletion. Implemented using a piezo-scanning stage on a laser scanning confocal fluorescence microscope system with FLIM realised using time correlated single photon counting (TCSPC), this provides convenient switching between confocal and STED-FLIM with spatial resolution down to below 60 nm. We will present our design considerations to make a robust instrument for biological applications including a comparison between fixed phase plate and spatial light modulator (SLM) approaches to shape the STED beam and the correlation of STED and confocal FLIM microscopy. Following our previous application of FLIM-FRET to study intercellular signalling at the immunological synapse (IS), we are employing STED microscopy to characterize the spatial distribution of cellular molecules with subdiffraction resolution at the IS. In particular, we are imaging cytoskeletal structure at the Natural Killer cell activated immune synapse. We will also present our progress towards multilabel STED microscopy to determine how relative spatial molecular organization, previously undetectable by conventional microscopy techniques, is important for NK cell cytotoxic function. Keywords: STED, Stimulated Emission Depletion Microscopy, Natural Killer (NK) cell, Fluorescence lifetime imaging, FLIM, Super resolution microscopy.

Toward an Objective Enhanced-V Detection Algorithm

NASA Technical Reports Server (NTRS)

Brunner, Jason; Feltz, Wayne; Moses, John; Rabin, Robert; Ackerman, Steven

2007-01-01

The area of coldest cloud tops above thunderstorms sometimes has a distinct V or U shape. This pattern, often referred to as an "enhanced-V' signature, has been observed to occur during and preceding severe weather in previous studies. This study describes an algorithmic approach to objectively detect enhanced-V features with observations from the Geostationary Operational Environmental Satellite and Low Earth Orbit data. The methodology consists of cross correlation statistics of pixels and thresholds of enhanced-V quantitative parameters. The effectiveness of the enhanced-V detection method will be examined using Geostationary Operational Environmental Satellite, MODerate-resolution Imaging Spectroradiometer, and Advanced Very High Resolution Radiometer image data from case studies in the 2003-2006 seasons. The main goal of this study is to develop an objective enhanced-V detection algorithm for future implementation into operations with future sensors, such as GOES-R.

Computed Tomography Studies of Lung Mechanics

PubMed Central

Simon, Brett A.; Christensen, Gary E.; Low, Daniel A.; Reinhardt, Joseph M.

2005-01-01

The study of lung mechanics has progressed from global descriptions of lung pressure and volume relationships to the high-resolution, three-dimensional, quantitative measurement of dynamic regional mechanical properties and displacements. X-ray computed tomography (CT) imaging is ideally suited to the study of regional lung mechanics in intact subjects because of its high spatial and temporal resolution, correlation of functional data with anatomic detail, increasing volumetric data acquisition, and the unique relationship between CT density and lung air content. This review presents an overview of CT measurement principles and limitations for the study of regional mechanics, reviews some of the early work that set the stage for modern imaging approaches and impacted the understanding and management of patients with acute lung injury, and presents evolving novel approaches for the analysis and application of dynamic volumetric lung image data. PMID:16352757

Improvement of spectral and axial resolutions in modified coded aperture correlation holography (COACH) imaging system

NASA Astrophysics Data System (ADS)

Vijayakumar, A.; Rosen, Joseph

2017-05-01

Coded aperture correlation holography (COACH) is a recently developed incoherent digital holographic technique. In COACH, two holograms are recorded: the object hologram for the object under study and another hologram for a point object called PSF hologram. The holograms are recorded by interfering two beams, both diffracted from the same object point, but only one of them passes through a random-like coded phase mask (CPM). The same CPM is used for recording the object as well as the PSF holograms. The image is reconstructed by correlating the object hologram with a processed version of the PSF hologram. The COACH holographic technique exhibits the same transverse and axial resolution of the regular imaging, but with the unique capability of storing 3D information. The basic COACH configuration consists of a single spatial light modulator (SLM) used for displaying the CPM. In this study, the basic COACH configuration has been advanced by employing two spatial light modulators (SLMs) in the setup. The refractive lens used in the basic COACH setup for collecting and collimating the light diffracted by the object is replaced by an SLM on which an equivalent diffractive lens is displayed. Unlike a refractive lens, the diffractive lens displayed on the first SLM focuses light with different wavelengths to different axial planes, which are separated by distances larger than the axial correlation lengths of the CPM for any visible wavelength. This characteristic extends the boundaries of COACH from three-dimensional to four-dimensional imaging with the wavelength as its fourth dimension.

Phase-detected Brillouin optical correlation-domain reflectometry

NASA Astrophysics Data System (ADS)

Mizuno, Yosuke; Hayashi, Neisei; Fukuda, Hideyuki; Nakamura, Kentaro

2018-05-01

Optical fiber sensing techniques based on Brillouin scattering have been extensively studied for structural health monitoring owing to their capability of distributed strain and temperature measurement. Although a higher signal-to-noise ratio (leading to high spatial resolution and high-speed measurement) is generally obtained for two-end-access systems, they reduce the degree of freedom in embedding the sensors into structures, and render the measurement no longer feasible when extremely high loss or breakage occurs at a point of the sensing fiber. To overcome these drawbacks, a one-end-access sensing technique called Brillouin optical correlation-domain reflectometry (BOCDR) has been developed. BOCDR has a high spatial resolution and cost efficiency, but its conventional configuration suffered from relatively low-speed operation. In this paper, we review the recently developed high-speed configurations of BOCDR, including phase-detected BOCDR, with which we demonstrate real-time distributed measurement by tracking a propagating mechanical wave. We also demonstrate breakage detection with a wide strain dynamic range.

The role of integrated high resolution stratigraphic and geophysic surveys for groundwater modelling

NASA Astrophysics Data System (ADS)

Margiotta, S.; Mazzone, F.; Negri, S.; Calora, M.

2008-10-01

This work sets out a methodology of integrated geological, hydrogeological and geophysical surveys for the characterization of contaminated sites. The flow model of the shallow aquifer in the Brindisi area (recognized to be at significant environmental risk by the Italian government) and the impact of an antrophic structure on the groundwater flow have been evaluated. The stratigraphic and hydrogeological targets used for the calibration phase of the flow model provide a means of assessing calibration quality. The good calibration of the model point out the key role of a detailed knowledge of the physical-stratigraphycal attributes of the area to be studied and field data collection. Geoelectrical tomography focus the attention on an area resulted of particular interest by the flow model obtained. This method permit to reconstruct in detail the lateral and vertical lithological variations in the geological formations improving the spatial resolution of the data and consequently the scale of observation. Besides, anomaly resistivity values have been correlated with pollution. Chemical analysis have confirmed this correlation.

Phase-detected Brillouin optical correlation-domain reflectometry

NASA Astrophysics Data System (ADS)

Mizuno, Yosuke; Hayashi, Neisei; Fukuda, Hideyuki; Nakamura, Kentaro

2018-06-01

Optical fiber sensing techniques based on Brillouin scattering have been extensively studied for structural health monitoring owing to their capability of distributed strain and temperature measurement. Although a higher signal-to-noise ratio (leading to high spatial resolution and high-speed measurement) is generally obtained for two-end-access systems, they reduce the degree of freedom in embedding the sensors into structures, and render the measurement no longer feasible when extremely high loss or breakage occurs at a point of the sensing fiber. To overcome these drawbacks, a one-end-access sensing technique called Brillouin optical correlation-domain reflectometry (BOCDR) has been developed. BOCDR has a high spatial resolution and cost efficiency, but its conventional configuration suffered from relatively low-speed operation. In this paper, we review the recently developed high-speed configurations of BOCDR, including phase-detected BOCDR, with which we demonstrate real-time distributed measurement by tracking a propagating mechanical wave. We also demonstrate breakage detection with a wide strain dynamic range.

High time resolution observations of the drivers of Forbush decreases

NASA Astrophysics Data System (ADS)

Jordan, A. P.; Spence, H. E.; Blake, J. B.; Mulligan, T. L.; Shaul, D. N.

2008-12-01

The drivers of Forbush decreases in galactic cosmic ray (GCR) fluxes are thought to be magnetic turbulence in the sheath of an interplanetary coronal mass ejection (ICME) and the closed magnetic field lines in the ICME itself. This model, however, is the result of studies utilizing hourly or longer time averaging. Such averaging can smooth over important correlations between variabilities in the GCR flux and those in the interplanetary medium. To test the validity of the current model of Forbush decreases, we analyze a number of Forbush decreases using high time resolution GCR data from the High Sensitivity Telescope (HIST) on Polar and the Spectrometer for INTEGRAL (SPI). We seek causal correlations between the onset of the decrease and structures in the solar wind plasma and interplanetary magnetic field, as measured concurrently with ACE and/or Wind. We find evidence that planar magnetic structures in the sheath preceding the ICME may be a factor in driving the decrease in at least one event.

What Do High-Resolution EIT Waves Tell Us About CMEs?

NASA Technical Reports Server (NTRS)

Thompson, Barbara

2010-01-01

Although many studies have demonstrated that some coronal waves are not generated by corona) mass ejections, we have learned a great deal about the ability of corona) mass ejections to drive large-scale corona) waves, also called "EIT waves." We present new results based on EIT wave amplitude, timing, speed, and direction of propagation, with respect to their correlation with CME-related dimmings, speeds, locations and widths. Furthermore, we demonstrate the ability to correlate different aspects of EIT waves with some of the observed structure of CMEs observed in coronagraph data. Finally, we expand on the discussion of the types of wave modes that can be generated by a corona) mass ejection, and how these observations can serve as a diagnostic of the type of impulse a CME can deliver to the surrounding corona. These diagnostics are obtained by examining the motion of individual field lines, requiring high-resolution observations like those provided by TRACE and SDO/AIA.

Observing the overall rocking motion of a protein in a crystal

NASA Astrophysics Data System (ADS)

Ma, Peixiang; Xue, Yi; Coquelle, Nicolas; Haller, Jens D.; Yuwen, Tairan; Ayala, Isabel; Mikhailovskii, Oleg; Willbold, Dieter; Colletier, Jacques-Philippe; Skrynnikov, Nikolai R.; Schanda, Paul

2015-10-01

The large majority of three-dimensional structures of biological macromolecules have been determined by X-ray diffraction of crystalline samples. High-resolution structure determination crucially depends on the homogeneity of the protein crystal. Overall `rocking' motion of molecules in the crystal is expected to influence diffraction quality, and such motion may therefore affect the process of solving crystal structures. Yet, so far overall molecular motion has not directly been observed in protein crystals, and the timescale of such dynamics remains unclear. Here we use solid-state NMR, X-ray diffraction methods and μs-long molecular dynamics simulations to directly characterize the rigid-body motion of a protein in different crystal forms. For ubiquitin crystals investigated in this study we determine the range of possible correlation times of rocking motion, 0.1-100 μs. The amplitude of rocking varies from one crystal form to another and is correlated with the resolution obtainable in X-ray diffraction experiments.

Band selective small flip angle COSY: a simple experiment for the analyses of 1H NMR spectra of small chiral molecules.

PubMed

Prabhu, Uday Ramesh; Suryaprakash, N

2008-12-01

The NMR spectroscopic discrimination of enantiomers in the chiral liquid crystalline solvent is more often carried out using (2)H detection in its natural abundance. The employment of (1)H detection for such a purpose is severely hampered due to significant loss of resolution in addition to indistinguishable overlap of the spectra from the two enantiomers. This study demonstrates that the band selected small flip angle homonuclear correlation experiment is a simple and robust technique that provides unambiguous discrimination, very high spectral resolution, reduced multiplicity of transitions, relative signs of the couplings and enormous saving of instrument time.

Coherent response of a semiconductor microcavity in the strong coupling regime

NASA Astrophysics Data System (ADS)

Cassabois, G.; Triques, A. L. C.; Ferreira, R.; Delalande, C.; Roussignol, Ph; Bogani, F.

2000-05-01

We have studied the coherent dynamics of a semiconductor microcavity by means of interferometric correlation measurements with subpicosecond time resolution in a backscattering geometry. Evidence is brought of the resolution of a homogeneous polariton line in an inhomogeneously broadened exciton system. Surprisingly, photon-like polaritons exhibit an inhomogeneous dephasing. Moreover, we observe an unexpected stationary coherence up to 8 ps for the lower polariton branch close to resonance. All these experimental results are well reproduced within the framework of a linear dispersion theory assuming a coherent superposition of the reflectivity and resonant Rayleigh scattering signals with a well-defined relative phase.

Space-resolved measurements of neutrons and ions emitted by a plasma focus

NASA Astrophysics Data System (ADS)

Jaeger, U.

1980-05-01

Space-resolved measurements of neutrons and of accelerated charged particles emitted by a plasma focus device are presented. The neutron source was measured with one and two dimensional paraffin collimators. The spatial resolution is 5 mn along the axis and the radius, with a time resolution of 10 ns. In order to make quantitative statements about the neutron yield, neutron scattering, absorption, and nuclear reactions were taken into account. Part of the neutron measurement was carried out together with time and space resolved measurements of the electron density to study possible correlations between n sub e and y sub n.

Changes in precipitation isotope-climate relationships from temporal grouping and aggregation of weekly-resolved USNIP data: impacts on paleoclimate and environmental applications

NASA Astrophysics Data System (ADS)

Akers, P. D.; Welker, J. M.

2015-12-01

Spatial variations in precipitation isotopes have been the focus of much recent research, but relatively less work has explored changes at various temporal scales. This is partly because most spatially-diverse and long-term isotope databases are offered at a monthly resolution, while daily or event-level records are spatially and temporally limited by cost and logistics. A subset of 25 United States Network for Isotopes in Precipitation (USNIP) sites with weekly-resolution in the east-central United States was analyzed for site-specific relationships between δ18O and δD (the local meteoric water line/LMWL), δ18O and surface temperature, and δ18O and precipitation amount. Weekly data were then aggregated into monthly and seasonal data to examine the effect of aggregation on correlation and slope values for each of the relationships. Generally, increasing aggregation improved correlations (>25% for some sites) due to a reduced effect of extreme values, but estimates on regression variable error increased (>100%) because of reduced sample sizes. Aggregation resulted in small, but significant drops (5-25%) in relationship slope values for some sites. Weekly data were also grouped by month and season to explore changes in relationships throughout the year. Significant subannual variability exists in slope values and correlations even for sites with very strong overall correlations. LMWL slopes are highest in winter and lowest in summer, while the δ18O-surface temperature relationship is strongest in spring. Despite these overall trends, a high level of month-to-month and season-to-season variability is the norm for these sites. Researchers blindly applying overall relationships drawn from monthly-resolved databases to paleoclimate or environmental research risk assuming these relationships apply at all temporal resolutions. When possible, researchers should match the temporal resolution used to calculate an isotopic relationship with the temporal resolution of their applied proxy.

Family Functioning, Identity Formation, and the Ability of Conflict Resolution among Adolescents

ERIC Educational Resources Information Center

Kiani, Behnaz; Hojatkhah, Seyed Mohsen; Torabi-Nami, Mohammad

2016-01-01

Family is perhaps the most influential system in individuals' life in which various behaviors are learnt. Family functioning refers to the ability of family to meet its responsibilities. The present correlation study used a multi-stage cluster sampling method to recruit 686 subjects including 338 males and 348 females from all high school students…

Google Scholar Goes to School: The Presence of Google Scholar on College and University Web Sites

ERIC Educational Resources Information Center

Neuhaus, Chris; Neuhaus, Ellen; Asher, Alan

2008-01-01

This study measured the degree of Google Scholar adoption within academia by analyzing the frequency of Google Scholar appearances on 948 campus and library Web sites, and by ascertaining the establishment of link resolution between Google Scholar and library resources. Results indicate a positive correlation between the implementation of Google…

MRI of articular cartilage at microscopic resolution

PubMed Central

Xia, Y.

2013-01-01

This review briefly summarises some of the definitive studies of articular cartilage by microscopic MRI (µMRI) that were conducted with the highest spatial resolutions. The article has four major sections. The first section introduces the cartilage tissue, MRI and µMRI, and the concept of image contrast in MRI. The second section describes the characteristic profiles of three relaxation times (T1, T2 and T1ρ) and self-diffusion in healthy articular cartilage. The third section discusses several factors that can influence the visualisation of articular cartilage and the detection of cartilage lesion by MRI and µMRI. These factors include image resolution, image analysis strategies, visualisation of the total tissue, topographical variations of the tissue properties, surface fibril ambiguity, deformation of the articular cartilage, and cartilage lesion. The final section justifies the values of multidisciplinary imaging that correlates MRI with other technical modalities, such as optical imaging. Rather than an exhaustive review to capture all activities in the literature, the studies cited in this review are merely illustrative. PMID:23610697

Observations of faint comets at McDonald Observatory: 1978-1980

NASA Technical Reports Server (NTRS)

Barker, E. S.; Cochran, A. L.; Rybski, P. M.

1981-01-01

Modern observational techniques, developed for spectroscopy and photometry of faint galaxies and quasars, successfully applied to faint comets on the 2.7 m telescope. The periodic comets Van Biesbrock, Ashbrook-Jackson, Schwassmann-Wachmann 1, Tempel 2, Encke, Forbes, Brooks 2, Stephan-Oterma and the new comets Bradfield (19791), Bowell (1980b), Chernis-Petrauskas (1980k) were observed. The comets ranged in magnitude from 10th to 20th magnitude. For comets fainter than 19th magnitude, reflectance spectra at 100A resolution and area photometry were obtained. On comets of 17th or 18th magnitude, spectrometric scans (6A resolution) of the nucleus or inner coma region. On those comets which are brighter than 16th magnitude spatial spectrophotometric (6A resolution) studies of the inner and extended comae were done. An extensive spatial study of the comae of P/Encke and P/Stephen-Oterma, correlated with heliocentric distance is taking place. The observing process used is described and examples of the results obtained to date are discussed.

The Correlation Between Pre and Postoperative Hearing Level with High Resolution Computed Tomography (HRCT) Findings in Congenital Canal Atresia (CAA) Patients.

PubMed

Asma, A; Abdul Fatah, A W; Hamzaini, A H; Mazita, A

2013-12-01

In managing patient with congenital congenital aural atresia (CAA), preoperative high resolution computed tomography (HRCT) scan and hearing assessment are important. A grading system based on HRCT findings was first introduced by Jahrsdoefer in order to select appropriate candidates for operation and to predict the postoperative hearing outcome in CAA patients. The score of eight and more was considered as a good prognostic factor for hearing reconstruction surgery. However previously in our center this score was not used as the criteria for surgical procedure. This study was conducted at Center A to evaluate the correlation between pre and postoperative hearing level with HRCT based on a Jahrsdoefer grading system in patients with CAA. All records and HRCT films with CAA from January 1997 until December 2007 at Center A were evaluated. The demographic data, operative records, pre and post operative hearing levels and HRCT findings were analyzed. Hearing level in this study was based on a pure tone average of air-bone gap at 500 Hz, 1 kHz and 2 kHz or hearing level obtained from auditory brainstem response eudiometry. This study was approved by Research Ethics Committee (code number, FF-197-2008). Thirty-two ears were retrospectively evaluated. The postoperative hearing level of 30 dB and less was considered as successful hearing result postoperatively. Of the six ears which underwent canalplasty, three had achieved successful hearing result. However, there was no significant correlation between preoperative hearing level (HL) with HRCT score and postoperative HL with HRCT score at 0.05 significant levels (correlation coefficient = -0.292, P = 0.105 and correlation coefficient = -0.127, P = 0.810) respectively. Hearing evaluation and HRCT temporal bone are two independent evaluations for the patients with CAA before going for hearing reconstructive surgery.

Stability of radiomic features in CT perfusion maps

NASA Astrophysics Data System (ADS)

Bogowicz, M.; Riesterer, O.; Bundschuh, R. A.; Veit-Haibach, P.; Hüllner, M.; Studer, G.; Stieb, S.; Glatz, S.; Pruschy, M.; Guckenberger, M.; Tanadini-Lang, S.

2016-12-01

This study aimed to identify a set of stable radiomic parameters in CT perfusion (CTP) maps with respect to CTP calculation factors and image discretization, as an input for future prognostic models for local tumor response to chemo-radiotherapy. Pre-treatment CTP images of eleven patients with oropharyngeal carcinoma and eleven patients with non-small cell lung cancer (NSCLC) were analyzed. 315 radiomic parameters were studied per perfusion map (blood volume, blood flow and mean transit time). Radiomics robustness was investigated regarding the potentially standardizable (image discretization method, Hounsfield unit (HU) threshold, voxel size and temporal resolution) and non-standardizable (artery contouring and noise threshold) perfusion calculation factors using the intraclass correlation (ICC). To gain added value for our model radiomic parameters correlated with tumor volume, a well-known predictive factor for local tumor response to chemo-radiotherapy, were excluded from the analysis. The remaining stable radiomic parameters were grouped according to inter-parameter Spearman correlations and for each group the parameter with the highest ICC was included in the final set. The acceptance level was 0.9 and 0.7 for the ICC and correlation, respectively. The image discretization method using fixed number of bins or fixed intervals gave a similar number of stable radiomic parameters (around 40%). The potentially standardizable factors introduced more variability into radiomic parameters than the non-standardizable ones with 56-98% and 43-58% instability rates, respectively. The highest variability was observed for voxel size (instability rate  >97% for both patient cohorts). Without standardization of CTP calculation factors none of the studied radiomic parameters were stable. After standardization with respect to non-standardizable factors ten radiomic parameters were stable for both patient cohorts after correction for inter-parameter correlations. Voxel size, image discretization, HU threshold and temporal resolution have to be standardized to build a reliable predictive model based on CTP radiomics analysis.

Real-time, high-resolution ultrasonography of the vocal folds--a prospective pilot study in patients before and after thyroidectomy.

PubMed

Dedecjus, Marek; Adamczewski, Zbigniew; Brzeziński, Jan; Lewiński, Andrzej

2010-09-01

The aim of the study was to evaluate the functionality of vocal folds (VF) by real-time, high-resolution ultrasonography (US) and to correlate the imaged features to results of laryngological examination (LE). The study group comprised 50 patients (41 females and nine males), qualified to thyroidectomy. All the patients had LE and US examination before and 2 days, 2 months, and 3 months after the surgery. We used high-resolution US imaging to identify VFs and, subsequently, a pulsed Doppler and Doppler gate to quantify the tissue displacement velocity in the vibrating VF section. LE revealed unilateral VF paralysis in two patients. VF dysfunction was diagnosed in other four subjects. In simultaneously performed US examination, changes in VF displacement velocity (VFDV) were observed in ten patients. In two subjects, VFDV was below 30 cm/s- patients with VF paralysis, diagnosed in LE. In a further eight cases, we observed VFDV decrease by 50%, comparing to preoperative values. Both US-imaging and LE, performed after the 3-month follow-up, confirmed the transitional character of the above-mentioned pathologies. US imaging of the VFs correlated with LE results, while being a minimally invasive, easily reproducible, and inexpensive method of examining VF functionality. Thanks to many recording options, it may soon become a perfect tool for an early identification of postoperative VF dysfunction with its later monitoring. To our knowledge, it is the first application of US and Doppler gate modes for VFDF quantification; however, an analysis on a larger group of patients is necessary to standardize the technique.

High resolution MRI of the normal finger at 0.1 T: anatomic correlations.

PubMed

Drapé, J L; Constantinesco, A; Arbogast, S; Sick, H; Wolfram-Gabel, R; Brunot, B

1992-01-01

MR images of the fingers are obtained in a 128 x 128 or 256 x 256 matrix format using a prototype of a mini imager dedicated to the hand. The vertical field of 0.1 T is provided by an electro-magnet with an air gap of 15 cm equipped with a single solenoidal coil. No Faraday cage is used. The maximum in plane pixel resolution of 100 mu is obtained for a field of view of 2.5 cm with a slice thickness of 2 mm. The identification of fine structures of the finger is demonstrated by the anatomical and histological correlations. This type of imager which is adapted to very limited field of views demonstrate that high resolution MRI of limb extremities can be achieved at 0.1 T.

An Evaluation of Population Density Mapping and Built up Area Estimates in Sri Lanka Using Multiple Methodologies

NASA Astrophysics Data System (ADS)

Engstrom, R.; Soundararajan, V.; Newhouse, D.

2017-12-01

In this study we examine how well multiple population density and built up estimates that utilize satellite data compare in Sri Lanka. The population relationship is examined at the Gram Niladhari (GN) level, the lowest administrative unit in Sri Lanka from the 2011 census. For this study we have two spatial domains, the whole country and a 3,500km2 sub-sample, for which we have complete high spatial resolution imagery coverage. For both the entire country and the sub-sample we examine how consistent are the existing publicly available measures of population constructed from satellite imagery at predicting population density? For just the sub-sample we examine how well do a suite of values derived from high spatial resolution satellite imagery predict population density and how does our built up area estimate compare to other publicly available estimates. Population measures were obtained from the Sri Lankan census, and were downloaded from Facebook, WorldPoP, GPW, and Landscan. Percentage built-up area at the GN level was calculated from three sources: Facebook, Global Urban Footprint (GUF), and the Global Human Settlement Layer (GHSL). For the sub-sample we have derived a variety of indicators from the high spatial resolution imagery. Using deep learning convolutional neural networks, an object oriented, and a non-overlapping block, spatial feature approach. Variables calculated include: cars, shadows (a proxy for building height), built up area, and buildings, roof types, roads, type of agriculture, NDVI, Pantex, and Histogram of Oriented Gradients (HOG) and others. Results indicate that population estimates are accurate at the higher, DS Division level but not necessarily at the GN level. Estimates from Facebook correlated well with census population (GN correlation of 0.91) but measures from GPW and WorldPop are more weakly correlated (0.64 and 0.34). Estimates of built-up area appear to be reliable. In the 32 DSD-subsample, Facebook's built- up area measure is highly correlated with our built-up measure (correlation of 0.9). Preliminary regression results based on variables selected from Lasso-regressions indicate that satellite indicators have exceptionally strong predictive power in predicting GN level population level and density with an out of sample r-squared of 0.75 and 0.72 respectively.

An atlas of high-resolution IRAS maps on nearby galaxies

NASA Technical Reports Server (NTRS)

Rice, Walter

1993-01-01

An atlas of far-infrared IRAS maps with near 1 arcmin angular resolution of 30 optically large galaxies is presented. The high-resolution IRAS maps were produced with the Maximum Correlation Method (MCM) image construction and enhancement technique developed at IPAC. The MCM technique, which recovers the spatial information contained in the overlapping detector data samples of the IRAS all-sky survey scans, is outlined and tests to verify the structural reliability and photometric integrity of the high-resolution maps are presented. The infrared structure revealed in individual galaxies is discussed. The atlas complements the IRAS Nearby Galaxy High-Resolution Image Atlas, the high-resolution galaxy images encoded in FITS format, which is provided to the astronomical community as an IPAC product.

Meteorological satellite data: A tool to describe the health of the world's agriculture

NASA Technical Reports Server (NTRS)

Gray, T. I., Jr.; Mccrary, D. G. (Principal Investigator); Scott, L.

1981-01-01

Local area coverage data acquired aboard the TIROS-N satellite family by the advanced very high resolution radiometer systems was examined to determine the agricultural information current. Albedo differences between channel 2 and channel 1 of the advanced very high resolution radiometer LAC (called EVI) are shown to be closely correlated to the Ashburn vegetative index produced from LANDSAT multispectral scanner data which have been shown to vary in response to "greenness", soil moisture, and crop production. The statistical correlation between the EVI and the Ashburn Vegetative Index (+ or - 1 deg) is 0.86.

Robust mosiacs of close-range high-resolution images

NASA Astrophysics Data System (ADS)

Song, Ran; Szymanski, John E.

2008-03-01

This paper presents a robust algorithm which relies only on the information contained within the captured images for the construction of massive composite mosaic images from close-range and high-resolution originals, such as those obtained when imaging architectural and heritage structures. We first apply Harris algorithm to extract a selection of corners and, then, employ both the intensity correlation and the spatial correlation between the corresponding corners for matching them. Then we estimate the eight-parameter projective transformation matrix by the genetic algorithm. Lastly, image fusion using a weighted blending function together with intensity compensation produces an effective seamless mosaic image.

Spatiotemporal characteristics and vascular sources of neural-specific and -nonspecific fMRI signals at submillimeter columnar resolution

PubMed Central

Moon, Chan Hong; Fukuda, Mitsuhiro; Kim, Seong-Gi

2012-01-01

The neural specificity of hemodynamic-based functional magnetic resonance imaging (fMRI) signals are dependent on both the vascular regulation and the sensitivity of the applied fMRI technique to different types and sizes of blood vessels. In order to examine the specificity of MRI-detectable hemodynamic responses, submillimeter blood oxygenation-level dependent (BOLD) and cerebral blood volume (CBV) fMRI studies were performed in a well-established cat orientation column model at 9.4 Tesla. Neural-nonspecific and -specific signals were separated by comparing the fMRI responses of orthogonal orientation stimuli. The BOLD response was dominantly neural-nonspecific, mostly originating from pial and intracortical emerging veins, and thus was highly correlated with baseline blood volume. Uneven baseline CBV may displace or distort small functional domains in high-resolution BOLD maps. The CBV response in the parenchyma exhibited dual spatiotemporal characteristics, a fast and early neural-nonspecific response (with 4.3-s time constant) and a slightly slower and delayed neural-specific response (with 9.4-s time constant). The nonspecific CBV signal originates from early-responding arteries and arterioles, while the specific CBV response, which is not correlated with baseline blood volume, arises from late-responding microvessels including small pre-capillary arterioles and capillaries. Our data indicate that although the neural specificity of CBV fMRI signals is dependent on stimulation duration, high-resolution functional maps can be obtained from steady-state CBV studies. PMID:22960251

Evaluation of advanced light scattering technology for microgravity experiments

NASA Technical Reports Server (NTRS)

Fredericks, W. J.; Rosenblum, W. M.

1990-01-01

The capabilities of modern light scattering equipment and the uses it might have in studying processes in microgravity are evaluated. Emphasis is on the resolution of polydisperse systems. This choice was made since a major use of light scattering was expected to be the study of crystal growth of macromolecules in low gravity environments. An evaluation of a modern photon correlation spectrometer and a Mie spectrometer is presented.

Angstrom-Resolution Magnetic Resonance Imaging of Single Molecules via Wave-Function Fingerprints of Nuclear Spins

NASA Astrophysics Data System (ADS)

Ma, Wen-Long; Liu, Ren-Bao

2016-08-01

Single-molecule sensitivity of nuclear magnetic resonance (NMR) and angstrom resolution of magnetic resonance imaging (MRI) are the highest challenges in magnetic microscopy. Recent development in dynamical-decoupling- (DD) enhanced diamond quantum sensing has enabled single-nucleus NMR and nanoscale NMR. Similar to conventional NMR and MRI, current DD-based quantum sensing utilizes the "frequency fingerprints" of target nuclear spins. The frequency fingerprints by their nature cannot resolve different nuclear spins that have the same noise frequency or differentiate different types of correlations in nuclear-spin clusters, which limit the resolution of single-molecule MRI. Here we show that this limitation can be overcome by using "wave-function fingerprints" of target nuclear spins, which is much more sensitive than the frequency fingerprints to the weak hyperfine interaction between the targets and a sensor under resonant DD control. We demonstrate a scheme of angstrom-resolution MRI that is capable of counting and individually localizing single nuclear spins of the same frequency and characterizing the correlations in nuclear-spin clusters. A nitrogen-vacancy-center spin sensor near a diamond surface, provided that the coherence time is improved by surface engineering in the near future, may be employed to determine with angstrom resolution the positions and conformation of single molecules that are isotope labeled. The scheme in this work offers an approach to breaking the resolution limit set by the "frequency gradients" in conventional MRI and to reaching the angstrom-scale resolution.

Three-dimensional optical coherence tomography of the embryonic murine cardiovascular system

NASA Astrophysics Data System (ADS)

Luo, Wei; Marks, Daniel L.; Ralston, Tyler S.; Boppart, Stephen A.

2006-03-01

Optical coherence tomography (OCT) is an emerging high-resolution real-time biomedical imaging technology that has potential as a novel investigational tool in developmental biology and functional genomics. In this study, murine embryos and embryonic hearts are visualized with an OCT system capable of 2-µm axial and 15-µm lateral resolution and with real-time acquisition rates. We present, to our knowledge, the first sets of high-resolution 2- and 3-D OCT images that reveal the internal structures of the mammalian (murine) embryo (E10.5) and embryonic (E14.5 and E17.5) cardiovascular system. Strong correlations are observed between OCT images and corresponding hematoxylin- and eosin-stained histological sections. Real-time in vivo embryonic (E10.5) heart activity is captured by spectral-domain optical coherence tomography, processed, and displayed at a continuous rate of five frames per second. With the ability to obtain not only high-resolution anatomical data but also functional information during cardiovascular development, the OCT technology has the potential to visualize and quantify changes in murine development and in congenital and induced heart disease, as well as enable a wide range of basic in vitro and in vivo research studies in functional genomics.

Infrared atmospheric sounding interferometer correlation interferometry for the retrieval of atmospheric gases: the case of H2O and CO2.

PubMed

Grieco, Giuseppe; Masiello, Guido; Serio, Carmine; Jones, Roderic L; Mead, Mohammed I

2011-08-01

Correlation interferometry is a particular application of Fourier transform spectroscopy with partially scanned interferograms. Basically, it is a technique to obtain the difference between the spectra of atmospheric radiance at two diverse spectral resolutions. Although the technique could be exploited to design an appropriate correlation interferometer, in this paper we are concerned with the analytical aspects of the method and its application to high-spectral-resolution infrared observations in order to separate the emission of a given atmospheric gas from a spectral signal dominated by surface emission, such as in the case of satellite spectrometers operated in the nadir looking mode. The tool will be used to address some basic questions concerning the vertical spatial resolution of H2O and to develop an algorithm to retrieve the columnar amount of CO2. An application to complete interferograms from the Infrared Atmospheric Sounding Interferometer will be presented and discussed. For H2O, we have concluded that the vertical spatial resolution in the lower troposphere mostly depends on broad features associated with the spectrum, whereas for CO2, we have derived a technique capable of retrieving a CO2 columnar amount with accuracy of ≈±7 parts per million by volume at the level of each single field of view.

Raman-spectroscopy-based chemical contaminant detection in milk powder

NASA Astrophysics Data System (ADS)

Dhakal, Sagar; Chao, Kuanglin; Qin, Jianwei; Kim, Moon S.

2015-05-01

Addition of edible and inedible chemical contaminants in food powders for purposes of economic benefit has become a recurring trend. In recent years, severe health issues have been reported due to consumption of food powders contaminated with chemical substances. This study examines the effect of spatial resolution used during spectral collection to select the optimal spatial resolution for detecting melamine in milk powder. Sample depth of 2mm, laser intensity of 200mw, and exposure time of 0.1s were previously determined as optimal experimental parameters for Raman imaging. Spatial resolution of 0.25mm was determined as the optimal resolution for acquiring spectral signal of melamine particles from a milk-melamine mixture sample. Using the optimal resolution of 0.25mm, sample depth of 2mm and laser intensity of 200mw obtained from previous study, spectral signal from 5 different concentration of milk-melamine mixture (1%, 0.5%, 0.1%, 0.05%, and 0.025%) were acquired to study the relationship between number of detected melamine pixels and corresponding sample concentration. The result shows that melamine concentration has a linear relation with detected number of melamine pixels with correlation coefficient of 0.99. It can be concluded that the quantitative analysis of powder mixture is dependent on many factors including physical characteristics of mixture, experimental parameters, and sample depth. The results obtained in this study are promising. We plan to apply the result obtained from this study to develop quantitative detection model for rapid screening of melamine in milk powder. This methodology can also be used for detection of other chemical contaminants in milk powders.

High-resolution x-ray absorption spectroscopy studies of metal compounds in neurodegenerative brain tissue

NASA Astrophysics Data System (ADS)

Collingwood, J. F.; Mikhaylova, A.; Davidson, M. R.; Batich, C.; Streit, W. J.; Eskin, T.; Terry, J.; Barrea, R.; Underhill, R. S.; Dobson, J.

2005-01-01

Fluorescence mapping and microfocus X-ray absorption spectroscopy are used to detect, locate and identify iron biominerals and other inorganic metal accumulations in neurodegenerative brain tissue at sub-cellular resolution (<5 microns). Recent progress in developing the technique is reviewed. Synchrotron X-rays are used to map tissue sections for metals of interest, and XANES and XAFS are used to characterise anomalous concentrations of the metals in-situ so that they can be correlated with tissue structures and disease pathology. Iron anomalies associated with biogenic magnetite, ferritin and haemoglobin are located and identified in an avian tissue model with a pixel resolution ~5 microns. Subsequent studies include brain tissue sections from transgenic Huntington's mice, and the first high-resolution mapping and identification of iron biominerals in human Alzheimer's and control autopsy brain tissue. Technical developments include use of microfocus diffraction to obtain structural information about biominerals in-situ, and depositing sample location grids by lithography for the location of anomalies by conventional microscopy. The combined techniques provide a breakthrough in the study of both intra- and extra-cellular iron compounds and related metals in tissue. The information to be gained from this approach has implications for future diagnosis and treatment of neurodegeneration, and for our understanding of the mechanisms involved.

Mapping Spatial Variability in Health and Wealth Indicators in Accra, Ghana Using High Spatial Resolution Imagery

NASA Astrophysics Data System (ADS)

Engstrom, R.; Ashcroft, E.

2014-12-01

There has been a tremendous amount of research conducted that examines disparities in health and wealth of persons between urban and rural areas however, relatively little research has been undertaken to examine variations within urban areas. A major limitation to elucidating differences with urban areas is the lack of social and demographic data at a sufficiently high spatial resolution to determine these differences. Generally the only available data that contain this information are census data which are collected at most every ten years and are often difficult to obtain at a high enough spatial resolution to allow for examining in depth variability in health and wealth indicators at high spatial resolutions, especially in developing countries. High spatial resolution satellite imagery may be able to provide timely and synoptic information that is related to health and wealth variability within a city. In this study we use two dates of Quickbird imagery (2003 and 2010) classified into the vegetation-impervious surface-soil (VIS) model introduced by Ridd (1995). For 2003 we only have partial coverage of the city, while for 2010 we have a mosaic, which covers the entire city of Accra, Ghana. Variations in the VIS values represent the physical variations within the city and these are compared to variations in economic, and/or sociodemographic data derived from the 2000 Ghanaian census at two spatial resolutions, the enumeration area (approximately US Census Tract) and the neighborhood for the city. Results indicate a significant correlation between both vegetation and impervious surface to type of cooking fuel used in the household, population density, housing density, availability of sewers, cooking space usage, and other variables. The correlations are generally stronger at the neighborhood level and the relationships are stable through time and space. Overall, the results indicate that information derived from high resolution satellite data is related to indicators of health and wealth within a developing world city and that the even if the imagery is collected 10 years after the census information, the relationships are still significant.

Weak data do not make a free lunch, only a cheap meal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Zhipu; Rajashankar, Kanagalaghatta; Dauter, Zbigniew, E-mail: dauter@anl.gov

2014-02-01

Refinement and analysis of four structures with various data resolution cutoffs suggests that at present there are no reliable criteria for judging the diffraction data resolution limit and the condition I/σ(I) = 2.0 is reasonable. However, extending the limit by about 0.2 Å beyond the resolution defined by this threshold does not deteriorate the quality of refined structures and in some cases may be beneficial. Four data sets were processed at resolutions significantly exceeding the criteria traditionally used for estimating the diffraction data resolution limit. The analysis of these data and the corresponding model-quality indicators suggests that the criteria ofmore » resolution limits widely adopted in the past may be somewhat conservative. Various parameters, such as R{sub merge} and I/σ(I), optical resolution and the correlation coefficients CC{sub 1/2} and CC*, can be used for judging the internal data quality, whereas the reliability factors R and R{sub free} as well as the maximum-likelihood target values and real-space map correlation coefficients can be used to estimate the agreement between the data and the refined model. However, none of these criteria provide a reliable estimate of the data resolution cutoff limit. The analysis suggests that extension of the maximum resolution by about 0.2 Å beyond the currently adopted limit where the I/σ(I) value drops to 2.0 does not degrade the quality of the refined structural models, but may sometimes be advantageous. Such an extension may be particularly beneficial for significantly anisotropic diffraction. Extension of the maximum resolution at the stage of data collection and structure refinement is cheap in terms of the required effort and is definitely more advisable than accepting a too conservative resolution cutoff, which is unfortunately quite frequent among the crystal structures deposited in the Protein Data Bank.« less

Low-resolution brain electromagnetic tomography (LORETA) identifies brain regions linked to psychometric performance under modafinil in narcolepsy.

PubMed

Saletu, Michael; Anderer, Peter; Semlitsch, Heribert V; Saletu-Zyhlarz, Gerda Maria; Mandl, Magdalena; Zeitlhofer, Josef; Saletu, Bernd

2007-01-15

Low-resolution brain electromagnetic tomography (LORETA) showed a functional deterioration of the fronto-temporo-parietal network of the right hemispheric vigilance system in narcolepsy and a therapeutic effect of modafinil. The aim of this study was to determine the effects of modafinil on cognitive and thymopsychic variables in patients with narcolepsy and investigate whether neurophysiological vigilance changes correlate with cognitive and subjective vigilance alterations at the behavioral level. In a double-blind, placebo-controlled crossover design, EEG-LORETA and psychometric data were obtained during midmorning hours in 15 narcoleptics before and after 3 weeks of placebo or 400 mg modafinil. Cognitive investigations included the Pauli Test and complex reaction time. Thymopsychic/psychophysiological evaluation comprised drive, mood, affectivity, wakefulness, depression, anxiety, the Symptom Checklist 90 and critical flicker frequency. The Multiple Sleep Latency Test (MSLT) and the Epworth Sleepiness Scale (ESS) were performed too. Cognitive performance (Pauli Test) was significantly better after modafinil than after placebo. Concerning reaction time and thymopsychic variables, no significant differences were observed. Correlation analyses revealed that a decrease in prefrontal delta, theta and alpha-1 power correlated with an improvement in cognitive performance. Moreover, drowsiness was positively correlated with theta power in parietal and medial prefrontal regions and beta-1 and beta-2 power in occipital regions. A less significant correlation was observed between midmorning EEG LORETA and the MSLT; between EEG LORETA and the ESS, the correlation was even weaker. In conclusion, modafinil did not influence thymopsychic variables in narcolepsy, but it significantly improved cognitive performance, which may be related to medial prefrontal activity processes identified by LORETA.

Spatial Representativeness of PM2.5 Concentrations Obtained Using Observations From Network Stations

NASA Astrophysics Data System (ADS)

Shi, Xiaoqin; Zhao, Chuanfeng; Jiang, Jonathan H.; Wang, Chunying; Yang, Xin; Yung, Yuk L.

2018-03-01

Haze has been a focused air pollution phenomenon in China, and its characterization is highly desired. Aerosol properties obtained from a single station are frequently used to represent the haze condition over a large domain, such as tens of kilometers, which could result in high uncertainties due to their spatial variation. Using a high-resolution network observation over an urban city in North China from November 2015 to February 2016, this study examines the spatial representativeness of ground station observations of particulate matter with diameters less than 2.5 μm (PM2.5). We developed a new method to determine the representative area of PM2.5 measurements from limited stations. The key idea is to determine the PM2.5 spatial representative area using its spatial variability and temporal correlation. We also determine stations with large representative area using two grid networks with different resolutions. Based on the high spatial resolution measurements, the representative area of PM2.5 at one station can be determined from the grids with high correlations and small differences of PM2.5. The representative area for a single station in the study period ranges from 0.25 to 16.25 km2 but is less than 3 km2 for more than half of the stations. The representative area varies with locations, and observation at 10 optimal stations would have a good representativeness of those obtained from 169 stations for the 4 month time scale studied. Both evaluations with an empirical orthogonal function analysis and with independent data set corroborate the validity of the results found in this study.

High lateral resolution exploration using surface waves from noise records

NASA Astrophysics Data System (ADS)

Chávez-García, Francisco José Yokoi, Toshiaki

2016-04-01

Determination of the shear-wave velocity structure at shallow depths is a constant necessity in engineering or environmental projects. Given the sensitivity of Rayleigh waves to shear-wave velocity, subsoil structure exploration using surface waves is frequently used. Methods such as the spectral analysis of surface waves (SASW) or multi-channel analysis of surface waves (MASW) determine phase velocity dispersion from surface waves generated by an active source recorded on a line of geophones. Using MASW, it is important that the receiver array be as long as possible to increase the precision at low frequencies. However, this implies that possible lateral variations are discarded. Hayashi and Suzuki (2004) proposed a different way of stacking shot gathers to increase lateral resolution. They combined strategies used in MASW with the common mid-point (CMP) summation currently used in reflection seismology. In their common mid-point with cross-correlation method (CMPCC), they cross-correlate traces sharing CMP locations before determining phase velocity dispersion. Another recent approach to subsoil structure exploration is based on seismic interferometry. It has been shown that cross-correlation of a diffuse field, such as seismic noise, allows the estimation of the Green's Function between two receivers. Thus, a virtual-source seismic section may be constructed from the cross-correlation of seismic noise records obtained in a line of receivers. In this paper, we use the seismic interferometry method to process seismic noise records obtained in seismic refraction lines of 24 geophones, and analyse the results using CMPCC to increase the lateral resolution of the results. Cross-correlation of the noise records allows reconstructing seismic sections with virtual sources at each receiver location. The Rayleigh wave component of the Green's Functions is obtained with a high signal-to-noise ratio. Using CMPCC analysis of the virtual-source seismic lines, we are able to identify lateral variations of phase velocity inside the seismic line, and increase the lateral resolution compared with results of conventional analysis.

Spectral characteristics of background error covariance and multiscale data assimilation

DOE PAGES

Li, Zhijin; Cheng, Xiaoping; Gustafson, Jr., William I.; ...

2016-05-17

The steady increase of the spatial resolutions of numerical atmospheric and oceanic circulation models has occurred over the past decades. Horizontal grid spacing down to the order of 1 km is now often used to resolve cloud systems in the atmosphere and sub-mesoscale circulation systems in the ocean. These fine resolution models encompass a wide range of temporal and spatial scales, across which dynamical and statistical properties vary. In particular, dynamic flow systems at small scales can be spatially localized and temporarily intermittent. Difficulties of current data assimilation algorithms for such fine resolution models are numerically and theoretically examined. Ourmore » analysis shows that the background error correlation length scale is larger than 75 km for streamfunctions and is larger than 25 km for water vapor mixing ratios, even for a 2-km resolution model. A theoretical analysis suggests that such correlation length scales prevent the currently used data assimilation schemes from constraining spatial scales smaller than 150 km for streamfunctions and 50 km for water vapor mixing ratios. Moreover, our results highlight the need to fundamentally modify currently used data assimilation algorithms for assimilating high-resolution observations into the aforementioned fine resolution models. Lastly, within the framework of four-dimensional variational data assimilation, a multiscale methodology based on scale decomposition is suggested and challenges are discussed.« less

Quantitative Protein Topography Analysis and High-Resolution Structure Prediction Using Hydroxyl Radical Labeling and Tandem-Ion Mass Spectrometry (MS)*

PubMed Central

Kaur, Parminder; Kiselar, Janna; Yang, Sichun; Chance, Mark R.

2015-01-01

Hydroxyl radical footprinting based MS for protein structure assessment has the goal of understanding ligand induced conformational changes and macromolecular interactions, for example, protein tertiary and quaternary structure, but the structural resolution provided by typical peptide-level quantification is limiting. In this work, we present experimental strategies using tandem-MS fragmentation to increase the spatial resolution of the technique to the single residue level to provide a high precision tool for molecular biophysics research. Overall, in this study we demonstrated an eightfold increase in structural resolution compared with peptide level assessments. In addition, to provide a quantitative analysis of residue based solvent accessibility and protein topography as a basis for high-resolution structure prediction; we illustrate strategies of data transformation using the relative reactivity of side chains as a normalization strategy and predict side-chain surface area from the footprinting data. We tested the methods by examination of Ca+2-calmodulin showing highly significant correlations between surface area and side-chain contact predictions for individual side chains and the crystal structure. Tandem ion based hydroxyl radical footprinting-MS provides quantitative high-resolution protein topology information in solution that can fill existing gaps in structure determination for large proteins and macromolecular complexes. PMID:25687570

92 Years of the Ising Model: A High Resolution Monte Carlo Study

NASA Astrophysics Data System (ADS)

Xu, Jiahao; Ferrenberg, Alan M.; Landau, David P.

2018-04-01

Using extensive Monte Carlo simulations that employ the Wolff cluster flipping and data analysis with histogram reweighting and quadruple precision arithmetic, we have investigated the critical behavior of the simple cubic Ising model with lattice sizes ranging from 163 to 10243. By analyzing data with cross correlations between various thermodynamic quantities obtained from the same data pool, we obtained the critical inverse temperature K c = 0.221 654 626(5) and the critical exponent of the correlation length ν = 0.629 912(86) with precision that improves upon previous Monte Carlo estimates.

Correlated Light and Electron Microscopy/Electron Tomography of Mitochondria In Situ

PubMed Central

Perkins, Guy A.; Sun, Mei G.; Frey, Terrence G.

2009-01-01

Three-dimensional light microscopy and three-dimensional electron microscopy (electron tomography) separately provide very powerful tools to study cellular structure and physiology, including the structure and physiology of mitochondria. Fluorescence microscopy allows one to study processes in live cells with specific labels and stains that follow the movement of labeled proteins and changes within cellular compartments but does not have sufficient resolution to define the ultrastructure of intracellular organelles such as mitochondria. Electron microscopy and electron tomography provide the highest resolution currently available to study mitochondrial ultrastructure but cannot follow processes in living cells. We describe the combination of these two techniques in which fluorescence confocal microscopy is used to study structural and physiologic changes in mitochondria within apoptotic HeLa cells to define the apoptotic timeframe. Cells can then be selected at various stages of the apoptotic timeframe for examination at higher resolution by electron microscopy and electron tomography. This is a form of “virtual” 4-dimensional electron microscopy that has revealed interesting structural changes in the mitochondria of HeLa cells during apoptosis. The same techniques can be applied, with modification, to study other dynamic processes within cells in other experimental contexts. PMID:19348881

Correlating Mediterranean shallow water deposits with global Oligocene-Miocene stratigraphy and oceanic events.

PubMed

Reuter, Markus; Piller, Werner E; Brandano, Marco; Harzhauser, Mathias

2013-12-01

Shallow-marine sediment records have the strong potential to display sensitive environmental changes in sedimentary geometries and skeletal content. However, the time resolution of most neritic carbonate records is not high enough to be compared with climatic events as recorded in the deep-sea sediment archives. In order to resolve the paleoceanographic and paleoclimatic changes during the Oligocene-Miocene transition in the Mediterranean shallow water carbonate systems with the best possible time resolution, we re-evaluated the Decontra section on the Maiella Platform (central Apennines, Italy), which acts as a reference for the correlation of Oligocene-Miocene shallow water deposits in the Mediterranean region. The 120-m-thick late Oligocene-late Miocene carbonate succession is composed of larger foraminiferal, bryozoan and corallinacean limestones interlayered with distinct planktonic foraminiferal carbonates representing a mostly outer neritic setting. Integrated multi-proxy and facies analyses indicate that CaCO 3 and total organic carbon contents as well as gamma-ray display only local to regional processes on the carbonate platform and are not suited for stratigraphic correlation on a wider scale. In contrast, new biostratigraphic data correlate the Decontra stable carbon isotope record to the global deep-sea carbon isotope record. This links relative sea level fluctuations, which are reflected by facies and magnetic susceptibility changes, to third-order eustatic cycles. The new integrated bio-, chemo-, and sequence stratigraphic framework enables a more precise timing of environmental changes within the studied time interval and identifies Decontra as an important locality for correlating not only shallow and deep water sediments of the Mediterranean region but also on a global scale.

Analysis of Correlation Tendency between Wind and Solar from Various Spatio-temporal Perspectives

NASA Astrophysics Data System (ADS)

Wang, X.; Weihua, X.; Mei, Y.

2017-12-01

Analysis of correlation between wind resources and solar resources could explore their complementary features, enhance the utilization efficiency of renewable energy and further alleviate the carbon emission issues caused by the fossil energy. In this paper, we discuss the correlation between wind and solar from various spatio-temporal perspectives (from east to west, in terms of plain, plateau, hill, and mountain, from hourly to daily, ten days and monthly) with observed data and modeled data from NOAA (National Oceanic and Atmospheric Administration) and NERL (National Renewable Energy Laboratory). With investigation of wind speed time series and solar radiation time series (period: 10 years, resolution: 1h) of 72 stations located in various landform and distributed dispersedly in USA, the results show that the correlation coefficient, Kendall's rank correlation coefficient, changes negative to positive value from east coast to west coast of USA, and this phenomena become more obvious when the time scale of resolution increases from daily to ten days and monthly. Furthermore, considering the differences of landforms which influence the local meteorology the Kendall coefficients of diverse topographies are compared and it is found that the coefficients descend from mountain to hill, plateau and plain. However, no such evident tendencies could be found in daily scale. According to this research, it is proposed that the complementary feature of wind resources and solar resources in the east or in the mountain area of USA is conspicuous. Subsequent study would try to further verify this analysis by investigating the operation status of wind power station and solar power station.

Breast density estimation from high spectral and spatial resolution MRI

PubMed Central

Li, Hui; Weiss, William A.; Medved, Milica; Abe, Hiroyuki; Newstead, Gillian M.; Karczmar, Gregory S.; Giger, Maryellen L.

2016-01-01

Abstract. A three-dimensional breast density estimation method is presented for high spectral and spatial resolution (HiSS) MR imaging. Twenty-two patients were recruited (under an Institutional Review Board--approved Health Insurance Portability and Accountability Act-compliant protocol) for high-risk breast cancer screening. Each patient received standard-of-care clinical digital x-ray mammograms and MR scans, as well as HiSS scans. The algorithm for breast density estimation includes breast mask generating, breast skin removal, and breast percentage density calculation. The inter- and intra-user variabilities of the HiSS-based density estimation were determined using correlation analysis and limits of agreement. Correlation analysis was also performed between the HiSS-based density estimation and radiologists’ breast imaging-reporting and data system (BI-RADS) density ratings. A correlation coefficient of 0.91 (p<0.0001) was obtained between left and right breast density estimations. An interclass correlation coefficient of 0.99 (p<0.0001) indicated high reliability for the inter-user variability of the HiSS-based breast density estimations. A moderate correlation coefficient of 0.55 (p=0.0076) was observed between HiSS-based breast density estimations and radiologists’ BI-RADS. In summary, an objective density estimation method using HiSS spectral data from breast MRI was developed. The high reproducibility with low inter- and low intra-user variabilities shown in this preliminary study suggest that such a HiSS-based density metric may be potentially beneficial in programs requiring breast density such as in breast cancer risk assessment and monitoring effects of therapy. PMID:28042590

Quantification of marine aerosol subgrid variability and its correlation with clouds based on high-resolution regional modeling: Quantifying Aerosol Subgrid Variability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Guangxing; Qian, Yun; Yan, Huiping

One limitation of most global climate models (GCMs) is that with the horizontal resolutions they typically employ, they cannot resolve the subgrid variability (SGV) of clouds and aerosols, adding extra uncertainties to the aerosol radiative forcing estimation. To inform the development of an aerosol subgrid variability parameterization, here we analyze the aerosol SGV over the southern Pacific Ocean simulated by the high-resolution Weather Research and Forecasting model coupled to Chemistry. We find that within a typical GCM grid, the aerosol mass subgrid standard deviation is 15% of the grid-box mean mass near the surface on a 1 month mean basis.more » The fraction can increase to 50% in the free troposphere. The relationships between the sea-salt mass concentration, meteorological variables, and sea-salt emission rate are investigated in both the clear and cloudy portion. Under clear-sky conditions, marine aerosol subgrid standard deviation is highly correlated with the standard deviations of vertical velocity, cloud water mixing ratio, and sea-salt emission rates near the surface. It is also strongly connected to the grid box mean aerosol in the free troposphere (between 2 km and 4 km). In the cloudy area, interstitial sea-salt aerosol mass concentrations are smaller, but higher correlation is found between the subgrid standard deviations of aerosol mass and vertical velocity. Additionally, we find that decreasing the model grid resolution can reduce the marine aerosol SGV but strengthen the correlations between the aerosol SGV and the total water mixing ratio (sum of water vapor, cloud liquid, and cloud ice mixing ratios).« less

Effect of static scatterers in laser speckle contrast imaging: an experimental study on correlation and contrast.

PubMed

Vaz, Pedro G; Humeau-Heurtier, Anne; Figueiras, Edite; Correia, Carlos; Cardoso, João

2017-12-29

Laser speckle contrast imaging (LSCI) is a non-invasive microvascular blood flow assessment technique with good temporal and spatial resolution. Most LSCI systems, including commercial devices, can perform only qualitative blood flow evaluation, which is a major limitation of this technique. There are several factors that prevent the utilization of LSCI as a quantitative technique. Among these factors, we can highlight the effect of static scatterers. The goal of this work was to study the influence of differences in static and dynamic scatterer concentration on laser speckle correlation and contrast. In order to achieve this, a laser speckle prototype was developed and tested using an optical phantom with various concentrations of static and dynamic scatterers. It was found that the laser speckle correlation could be used to estimate the relative concentration of static/dynamic scatterers within a sample. Moreover, the speckle correlation proved to be independent of the dynamic scatterer velocity, which is a fundamental characteristic to be used in contrast correction.

Efficient Strategies for Estimating the Spatial Coherence of Backscatter

PubMed Central

Hyun, Dongwoon; Crowley, Anna Lisa C.; Dahl, Jeremy J.

2017-01-01

The spatial coherence of ultrasound backscatter has been proposed to reduce clutter in medical imaging, to measure the anisotropy of the scattering source, and to improve the detection of blood flow. These techniques rely on correlation estimates that are obtained using computationally expensive strategies. In this study, we assess existing spatial coherence estimation methods and propose three computationally efficient modifications: a reduced kernel, a downsampled receive aperture, and the use of an ensemble correlation coefficient. The proposed methods are implemented in simulation and in vivo studies. Reducing the kernel to a single sample improved computational throughput and improved axial resolution. Downsampling the receive aperture was found to have negligible effect on estimator variance, and improved computational throughput by an order of magnitude for a downsample factor of 4. The ensemble correlation estimator demonstrated lower variance than the currently used average correlation. Combining the three methods, the throughput was improved 105-fold in simulation with a downsample factor of 4 and 20-fold in vivo with a downsample factor of 2. PMID:27913342

Effect of static scatterers in laser speckle contrast imaging: an experimental study on correlation and contrast

NASA Astrophysics Data System (ADS)

Vaz, Pedro G.; Humeau-Heurtier, Anne; Figueiras, Edite; Correia, Carlos; Cardoso, João

2018-01-01

Laser speckle contrast imaging (LSCI) is a non-invasive microvascular blood flow assessment technique with good temporal and spatial resolution. Most LSCI systems, including commercial devices, can perform only qualitative blood flow evaluation, which is a major limitation of this technique. There are several factors that prevent the utilization of LSCI as a quantitative technique. Among these factors, we can highlight the effect of static scatterers. The goal of this work was to study the influence of differences in static and dynamic scatterer concentration on laser speckle correlation and contrast. In order to achieve this, a laser speckle prototype was developed and tested using an optical phantom with various concentrations of static and dynamic scatterers. It was found that the laser speckle correlation could be used to estimate the relative concentration of static/dynamic scatterers within a sample. Moreover, the speckle correlation proved to be independent of the dynamic scatterer velocity, which is a fundamental characteristic to be used in contrast correction.

Observation and simulation of net primary productivity in Qilian Mountain, western China.

PubMed

Zhou, Y; Zhu, Q; Chen, J M; Wang, Y Q; Liu, J; Sun, R; Tang, S

2007-11-01

We modeled net primary productivity (NPP) at high spatial resolution using an advanced spaceborne thermal emission and reflection radiometer (ASTER) image of a Qilian Mountain study area using the boreal ecosystem productivity simulator (BEPS). Two key driving variables of the model, leaf area index (LAI) and land cover type, were derived from ASTER and moderate resolution imaging spectroradiometer (MODIS) data. Other spatially explicit inputs included daily meteorological data (radiation, precipitation, temperature, humidity), available soil water holding capacity (AWC), and forest biomass. NPP was estimated for coniferous forests and other land cover types in the study area. The result showed that NPP of coniferous forests in the study area was about 4.4 tCha(-1)y(-1). The correlation coefficient between the modeled NPP and ground measurements was 0.84, with a mean relative error of about 13.9%.

MERLIN - A meV Resolution Beamline at the ALS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reininger, Ruben; Bozek, John; Chuang, Y.-D.

2007-01-19

An ultra-high resolution beamline is being constructed at the Advanced Light Source (ALS) for the study of low energy excitations in strongly correlated systems with the use of high-resolution inelastic scattering and angle-resolved photoemission. This new beamline, given the acronym Merlin (for meV resolution line), will cover the energy range 10-150 eV. The monochromator has fixed entrance and exit slits and a plane mirror that can illuminate a spherical grating at the required angle of incidence (as in the SX-700 mechanism). The monochromator can be operated in two different modes. In the highest resolution mode, the energy scanning requires translatingmore » the monochromator chamber (total travel 1.1 m) as well as rotating the grating and the plane mirror in front of the grating. The resolution in this mode is practically determined by the slits width. In the second mode, the scanning requires rotating the grating and the plane mirror. This mode can be used to scan a few eV without a significant resolution loss. The source for the beamline is a 1.9 m long, 90 mm period quasi periodic EPU. The expected flux at the sample is higher than 1011 photons/s at a resolving power of 5 x 104 in the energy range 16-130 eV. A second set of gratings can be used to obtain higher flux at the expense of resolution.« less

Conflict resolution and adaptation in normal aging: the role of verbal intelligence and cognitive reserve.

PubMed

Puccioni, Olga; Vallesi, Antonino

2012-12-01

The present study investigated effects of cognitive aging on conflict resolution (the ability to suppress prepotent and distracting, irrelevant information) and conflict adaptation (the adjustment of conflict resolution based on previously experienced conflict level). In addition, it aimed at investigating whether Cognitive Reserve (CR) and intelligence play a compensatory role against age-related deficits in both factors. A color-word Stroop task with no feature repetitions (i.e., neither the word nor the color was repeated in two subsequent trials) was administered to 23 older adults with no dimentia (65-79 years old) and 22 younger controls (18-34 years old), in addition to measures of intelligence and CR. Older adults' performance was characterized by general slowing. However, response slowing inversely correlated with intelligence, education, and a cognitive-reserve index. The Stroop effect (i.e., response-time (RT) difference between incongruent and congruent conditions) was larger in older adults than in younger controls, and in the older group only, it negatively correlated with verbal IQ. With this feature-repetitions-free Stroop task, we confirmed the presence of some conflict adaptation effects, which, however, were spared by aging. Altogether, these findings show that older adults can cope better with age-related impairment in verbal interference resolution, if they have enough intelligence resources in a related (verbal) domain, whereas CR plays a role in general performance speed only. We therefore suggest that general and specific accounts of cognitive aging may apply to different processing stages, which are influenced by partially different compensatory factors. 2013 APA, all rights reserved

The Anomalous Influence of Spectral Resolution on Pulsed THz Time Domain Spectroscopy under Real Conditions

PubMed Central

Trofimov, Vyacheslav A.; Varentsova, Svetlana A.

2017-01-01

We have studied the spectral resolution influence on the accuracy of the substance detection and identification at using a broadband THz pulse measured under real conditions (at a distance of more than 3 m from a THz emitter in ambient air with a relative humidity of about 50%). We show that increasing spectral resolution leads to manifestation of small-scale perturbations (random fluctuations) in the signal spectrum caused by the influence of the environment or the sample structure. Decreasing the spectral resolution allows us to exclude from consideration this small-scale modulation of the signal as well as to detect the water vapor absorption frequencies. This fact is important in practice because it allows us to increase the signal processing rate. In order to increase the detection reliability, it is advisable to decrease the spectral resolution up to values of not more than 40% of the corresponding spectral line bandwidth. The method of spectral dynamics analysis together with the integral correlation criteria is used for the substance detection and identification. Neutral substances such as chocolate and cookies are used as the samples in the physical experiment. PMID:29231895

Iodine imaging in thyroid by fluorescent X-ray CT with 0.05 mm spatial resolution

NASA Astrophysics Data System (ADS)

Takeda, T.; Yu, Q.; Yashiro, T.; Zeniya, T.; Wu, J.; Hasegawa, Y.; Thet-Thet-Lwin; Hyodo, K.; Yuasa, T.; Dilmanian, F. A.; Akatsuka, T.; Itai, Y.

2001-07-01

Fluorescent X-ray computed tomography (FXCT) at a 0.05 mm in-plane spatial resolution and 0.05 mm slice thickness depicted the cross sectional distribution of endogenous iodine within thyroid. The distribution obtained from the FXCT image correlated closely to that obtained from the pathological pictures.

Improvements in High Speed, High Resolution Dynamic Digital Image Correlation for Experimental Evaluation of Composite Drive System Components

NASA Technical Reports Server (NTRS)

Kohlman, Lee W.; Ruggeri, Charles R.; Roberts, Gary D.; Handschuh, Robert Frederick

2013-01-01

Composite materials have the potential to reduce the weight of rotating drive system components. However, these components are more complex to design and evaluate than static structural components in part because of limited ability to acquire deformation and failure initiation data during dynamic tests. Digital image correlation (DIC) methods have been developed to provide precise measurements of deformation and failure initiation for material test coupons and for structures under quasi-static loading. Attempts to use the same methods for rotating components (presented at the AHS International 68th Annual Forum in 2012) are limited by high speed camera resolution, image blur, and heating of the structure by high intensity lighting. Several improvements have been made to the system resulting in higher spatial resolution, decreased image noise, and elimination of heating effects. These improvements include the use of a high intensity synchronous microsecond pulsed LED lighting system, different lenses, and changes in camera configuration. With these improvements, deformation measurements can be made during rotating component tests with resolution comparable to that which can be achieved in static tests

Improvements in High Speed, High Resolution Dynamic Digital Image Correlation for Experimental Evaluation of Composite Drive System Components

NASA Technical Reports Server (NTRS)

Kohlman, Lee; Ruggeri, Charles; Roberts, Gary; Handshuh, Robert

2013-01-01

Composite materials have the potential to reduce the weight of rotating drive system components. However, these components are more complex to design and evaluate than static structural components in part because of limited ability to acquire deformation and failure initiation data during dynamic tests. Digital image correlation (DIC) methods have been developed to provide precise measurements of deformation and failure initiation for material test coupons and for structures under quasi-static loading. Attempts to use the same methods for rotating components (presented at the AHS International 68th Annual Forum in 2012) are limited by high speed camera resolution, image blur, and heating of the structure by high intensity lighting. Several improvements have been made to the system resulting in higher spatial resolution, decreased image noise, and elimination of heating effects. These improvements include the use of a high intensity synchronous microsecond pulsed LED lighting system, different lenses, and changes in camera configuration. With these improvements, deformation measurements can be made during rotating component tests with resolution comparable to that which can be achieved in static tests.

Scintillator Non-Proportionality: Present Understanding and Future Challenges

NASA Astrophysics Data System (ADS)

Moses, W. W.; Payne, S. A.; Choong, W.-S.; Hull, G.; Reutter, B. W.

2008-06-01

Scintillator non-proportionality (the fact that the conversion factor between the energy deposited in a scintillator and the number of visible photons produced is not constant) has been studied both experimentally and theoretically for 50 years. Early research centered on the dependence of the conversion factor on the species of the ionizing radiation (gamma, alpha, beta, proton, etc.), and researchers during the 1960s discovered a strong correlation between the scintillation efficiency and the ionization density. In more recent years, non-proportionality has been proposed as the reason why the energy resolution of most scintillators is worse than that predicted by counting statistics. While much progress has been made, there are still major gaps in our understanding of both the fundamental causes of non-proportionality and their quantitative link to scintillator energy resolution. This paper summarizes the present state of knowledge on the nature of the light-yield non-proportionality and its effect on energy resolution.

Resolution Studies at Beam Position Monitors at the FLASH Facility at DESY

NASA Astrophysics Data System (ADS)

Baboi, N.; Lund-Nielsen, J.; Noelle, D.; Riesch, W.; Traber, T.; Kruse, J.; Wendt, M.

2006-11-01

More than 60 beam position monitors (BPM) are installed along about 350m of beamline of the Free Electron LASer in Hamburg (FLASH) at DESY. The room-temperature part of the accelerator is equipped mainly with stripline position monitors. In the accelerating cryo-modules there are cavity and re-entrant cavity BPMs, which will not be discussed here. In the undulator part of the machine button BPMs are used. This area requires a single bunch resolution of 10μm. The electronics is based on the AM/PM normalization principle and is externally triggered. Single-bunch position is measured. This paper presents the methods used to determine the resolution of the BPMs. The results based on correlations between different BPMs along the machine are compared to noise measurements in the RF lab. The performance and difficulties with the BPM design and the current electronics as well as its development are discussed.

Quantification of dopamine transporters in the mouse brain using ultra-high resolution single-photon emission tomography.

PubMed

Acton, Paul D; Choi, Seok-Rye; Plössl, Karl; Kung, Hank F

2002-05-01

Functional imaging of small animals, such as mice and rats, using ultra-high resolution positron emission tomography (PET) and single-photon emission tomography (SPET), is becoming a valuable tool for studying animal models of human disease. While several studies have shown the utility of PET imaging in small animals, few have used SPET in real research applications. In this study we aimed to demonstrate the feasibility of using ultra-high resolution SPET in quantitative studies of dopamine transporters (DAT) in the mouse brain. Four healthy ICR male mice were injected with (mean+/-SD) 704+/-154 MBq [(99m)Tc]TRODAT-1, and scanned using an ultra-high resolution SPET system equipped with pinhole collimators (spatial resolution 0.83 mm at 3 cm radius of rotation). Each mouse had two studies, to provide an indication of test-retest reliability. Reference tissue kinetic modeling analysis of the time-activity data in the striatum and cerebellum was used to quantitate the availability of DAT. A simple equilibrium ratio of striatum to cerebellum provided another measure of DAT binding. The SPET imaging results were compared against ex vivo biodistribution data from the striatum and cerebellum. The mean distribution volume ratio (DVR) from the reference tissue kinetic model was 2.17+/-0.34, with a test-retest reliability of 2.63%+/-1.67%. The ratio technique gave similar results (DVR=2.03+/-0.38, test-retest reliability=6.64%+/-3.86%), and the ex vivo analysis gave DVR=2.32+/-0.20. Correlations between the kinetic model and the ratio technique ( R(2)=0.86, P<0.001) and the ex vivo data ( R(2)=0.92, P=0.04) were both excellent. This study demonstrated clearly that ultra-high resolution SPET of small animals is capable of accurate, repeatable, and quantitative measures of DAT binding, and should open up the possibility of further studies of cerebral binding sites in mice using pinhole SPET.

Porous media flux sensitivity to pore-scale geostatistics: A bottom-up approach

NASA Astrophysics Data System (ADS)

Di Palma, P. R.; Guyennon, N.; Heße, F.; Romano, E.

2017-04-01

Macroscopic properties of flow through porous media can be directly computed by solving the Navier-Stokes equations at the scales related to the actual flow processes, while considering the porous structures in an explicit way. The aim of this paper is to investigate the effects of the pore-scale spatial distribution on seepage velocity through numerical simulations of 3D fluid flow performed by the lattice Boltzmann method. To this end, we generate multiple random Gaussian fields whose spatial correlation follows an assigned semi-variogram function. The Exponential and Gaussian semi-variograms are chosen as extreme-cases of correlation for short distances and statistical properties of the resulting porous media (indicator field) are described using the Matèrn covariance model, with characteristic lengths of spatial autocorrelation (pore size) varying from 2% to 13% of the linear domain. To consider the sensitivity of the modeling results to the geostatistical representativeness of the domain as well as to the adopted resolution, porous media have been generated repetitively with re-initialized random seeds and three different resolutions have been tested for each resulting realization. The main difference among results is observed between the two adopted semi-variograms, indicating that the roughness (short distances autocorrelation) is the property mainly affecting the flux. However, computed seepage velocities show additionally a wide variability (about three orders of magnitude) for each semi-variogram model in relation to the assigned correlation length, corresponding to pore sizes. The spatial resolution affects more the results for short correlation lengths (i.e., small pore sizes), resulting in an increasing underestimation of the seepage velocity with the decreasing correlation length. On the other hand, results show an increasing uncertainty as the correlation length approaches the domain size.

A double-correlation tremor-location method

NASA Astrophysics Data System (ADS)

Li, Ka Lok; Sgattoni, Giulia; Sadeghisorkhani, Hamzeh; Roberts, Roland; Gudmundsson, Olafur

2017-02-01

A double-correlation method is introduced to locate tremor sources based on stacks of complex, doubly-correlated tremor records of multiple triplets of seismographs back projected to hypothetical source locations in a geographic grid. Peaks in the resulting stack of moduli are inferred source locations. The stack of the moduli is a robust measure of energy radiated from a point source or point sources even when the velocity information is imprecise. Application to real data shows how double correlation focuses the source mapping compared to the common single correlation approach. Synthetic tests demonstrate the robustness of the method and its resolution limitations which are controlled by the station geometry, the finite frequency of the signal, the quality of the used velocity information and noise level. Both random noise and signal or noise correlated at time shifts that are inconsistent with the assumed velocity structure can be effectively suppressed. Assuming a surface wave velocity, we can constrain the source location even if the surface wave component does not dominate. The method can also in principle be used with body waves in 3-D, although this requires more data and seismographs placed near the source for depth resolution.

Downscaling 250-m MODIS growing season NDVI based on multiple-date landsat images and data mining approaches

USGS Publications Warehouse

Gu, Yingxin; Wylie, Bruce K.

2015-01-01

The satellite-derived growing season time-integrated Normalized Difference Vegetation Index (GSN) has been used as a proxy for vegetation biomass productivity. The 250-m GSN data estimated from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensors have been used for terrestrial ecosystem modeling and monitoring. High temporal resolution with a wide range of wavelengths make the MODIS land surface products robust and reliable. The long-term 30-m Landsat data provide spatial detailed information for characterizing human-scale processes and have been used for land cover and land change studies. The main goal of this study is to combine 250-m MODIS GSN and 30-m Landsat observations to generate a quality-improved high spatial resolution (30-m) GSN database. A rule-based piecewise regression GSN model based on MODIS and Landsat data was developed. Results show a strong correlation between predicted GSN and actual GSN (r = 0.97, average error = 0.026). The most important Landsat variables in the GSN model are Normalized Difference Vegetation Indices (NDVIs) in May and August. The derived MODIS-Landsat-based 30-m GSN map provides biophysical information for moderate-scale ecological features. This multiple sensor study retains the detailed seasonal dynamic information captured by MODIS and leverages the high-resolution information from Landsat, which will be useful for regional ecosystem studies.

Adaptive windowing in contrast-enhanced intravascular ultrasound imaging.

PubMed

Lindsey, Brooks D; Martin, K Heath; Jiang, Xiaoning; Dayton, Paul A

2016-08-01

Intravascular ultrasound (IVUS) is one of the most commonly-used interventional imaging techniques and has seen recent innovations which attempt to characterize the risk posed by atherosclerotic plaques. One such development is the use of microbubble contrast agents to image vasa vasorum, fine vessels which supply oxygen and nutrients to the walls of coronary arteries and typically have diameters less than 200μm. The degree of vasa vasorum neovascularization within plaques is positively correlated with plaque vulnerability. Having recently presented a prototype dual-frequency transducer for contrast agent-specific intravascular imaging, here we describe signal processing approaches based on minimum variance (MV) beamforming and the phase coherence factor (PCF) for improving the spatial resolution and contrast-to-tissue ratio (CTR) in IVUS imaging. These approaches are examined through simulations, phantom studies, ex vivo studies in porcine arteries, and in vivo studies in chicken embryos. In phantom studies, PCF processing improved CTR by a mean of 4.2dB, while combined MV and PCF processing improved spatial resolution by 41.7%. Improvements of 2.2dB in CTR and 37.2% in resolution were observed in vivo. Applying these processing strategies can enhance image quality in conventional B-mode IVUS or in contrast-enhanced IVUS, where signal-to-noise ratio is relatively low and resolution is at a premium. Copyright © 2016 Elsevier B.V. All rights reserved.

Trees grow on money: Urban tree canopy cover and environmental justice

Treesearch

Kirsten Schwarz; Michail Fragkias; Christopher G. Boone; Weiqi Zhou; Melissa McHale; J. Morgan Grove; Jarlath O' Neil-Dunne; Joseph P. McFadden; Geoffrey L. Buckley; Dan Childers; Laura Ogden; Stephanie Pincetl; Diane Pataki; Ali Whitmer; Mary L. Cadenasso; Steven Arthur Loiselle

2015-01-01

This study examines the distributional equity of urban tree canopy (UTC) cover for Baltimore, MD, Los Angeles, CA, New York, NY, Philadelphia, PA, Raleigh, NC, Sacramento, CA, and Washington, D.C. using high spatial resolution land cover data and census data. Data are analyzed at the Census Block Group levels using Spearman’s correlation, ordinary least squares...

Procedural Justice in Family Conflict Resolution and Deviant Peer Group Involvement among Adolescents: The Mediating Influence of Peer Conflict

ERIC Educational Resources Information Center

Stuart, Jennifer; Fondacaro, Mark; Miller, Scott A.; Brown, Veda; Brank, Eve M.

2008-01-01

The involvement of adolescents with deviant peer groups is one of the strongest proximal correlates to juvenile delinquency and stems from a variety of causes. Past research has linked ineffective parenting with peer variables, including deviant peer group involvement and peer conflict during adolescence. In this study, adolescents' appraisals of…

Corn and sorghum phenotyping using a fixed-wing UAV-based remote sensing system

NASA Astrophysics Data System (ADS)

Shi, Yeyin; Murray, Seth C.; Rooney, William L.; Valasek, John; Olsenholler, Jeff; Pugh, N. Ace; Henrickson, James; Bowden, Ezekiel; Zhang, Dongyan; Thomasson, J. Alex

2016-05-01

Recent development of unmanned aerial systems has created opportunities in automation of field-based high-throughput phenotyping by lowering flight operational cost and complexity and allowing flexible re-visit time and higher image resolution than satellite or manned airborne remote sensing. In this study, flights were conducted over corn and sorghum breeding trials in College Station, Texas, with a fixed-wing unmanned aerial vehicle (UAV) carrying two multispectral cameras and a high-resolution digital camera. The objectives were to establish the workflow and investigate the ability of UAV-based remote sensing for automating data collection of plant traits to develop genetic and physiological models. Most important among these traits were plant height and number of plants which are currently manually collected with high labor costs. Vegetation indices were calculated for each breeding cultivar from mosaicked and radiometrically calibrated multi-band imagery in order to be correlated with ground-measured plant heights, populations and yield across high genetic-diversity breeding cultivars. Growth curves were profiled with the aerial measured time-series height and vegetation index data. The next step of this study will be to investigate the correlations between aerial measurements and ground truth measured manually in field and from lab tests.

Stochastic Ocean Eddy Perturbations in a Coupled General Circulation Model.

NASA Astrophysics Data System (ADS)

Howe, N.; Williams, P. D.; Gregory, J. M.; Smith, R. S.

2014-12-01

High-resolution ocean models, which are eddy permitting and resolving, require large computing resources to produce centuries worth of data. Also, some previous studies have suggested that increasing resolution does not necessarily solve the problem of unresolved scales, because it simply introduces a new set of unresolved scales. Applying stochastic parameterisations to ocean models is one solution that is expected to improve the representation of small-scale (eddy) effects without increasing run-time. Stochastic parameterisation has been shown to have an impact in atmosphere-only models and idealised ocean models, but has not previously been studied in ocean general circulation models. Here we apply simple stochastic perturbations to the ocean temperature and salinity tendencies in the low-resolution coupled climate model, FAMOUS. The stochastic perturbations are implemented according to T(t) = T(t-1) + (ΔT(t) + ξ(t)), where T is temperature or salinity, ΔT is the corresponding deterministic increment in one time step, and ξ(t) is Gaussian noise. We use high-resolution HiGEM data coarse-grained to the FAMOUS grid to provide information about the magnitude and spatio-temporal correlation structure of the noise to be added to the lower resolution model. Here we present results of adding white and red noise, showing the impacts of an additive stochastic perturbation on mean climate state and variability in an AOGCM.

An Optimised System for Generating Multi-Resolution Dtms Using NASA Mro Datasets

NASA Astrophysics Data System (ADS)

Tao, Y.; Muller, J.-P.; Sidiropoulos, P.; Veitch-Michaelis, J.; Yershov, V.

2016-06-01

Within the EU FP-7 iMars project, a fully automated multi-resolution DTM processing chain, called Co-registration ASP-Gotcha Optimised (CASP-GO) has been developed, based on the open source NASA Ames Stereo Pipeline (ASP). CASP-GO includes tiepoint based multi-resolution image co-registration and an adaptive least squares correlation-based sub-pixel refinement method called Gotcha. The implemented system guarantees global geo-referencing compliance with respect to HRSC (and thence to MOLA), provides refined stereo matching completeness and accuracy based on the ASP normalised cross-correlation. We summarise issues discovered from experimenting with the use of the open-source ASP DTM processing chain and introduce our new working solutions. These issues include global co-registration accuracy, de-noising, dealing with failure in matching, matching confidence estimation, outlier definition and rejection scheme, various DTM artefacts, uncertainty estimation, and quality-efficiency trade-offs.

Four-dimensional positron age-momentum correlation

NASA Astrophysics Data System (ADS)

Ackermann, Ulrich; Löwe, Benjamin; Dickmann, Marcel; Mitteneder, Johannes; Sperr, Peter; Egger, Werner; Reiner, Markus; Dollinger, Günther

2016-11-01

We have performed first four-dimensional age-momentum correlation (4D-AMOC) measurements at a pulsed high intensity positron micro beam and determined the absolute value of the three-dimensional momentum of the electrons annihilating with the positrons in coincidence with the positron age in the sample material. We operated two position sensitive detectors in coincidence to measure the annihilation radiation: a pixelated HPGe-detector and a microchannel plate image intensifier with a CeBr3 scintillator pixel array. The transversal momentum resolution of the 4D-AMOC setup was measured to be about 17 × 10-3 {m}0c (FWHM) and was circa 3.5 times larger than the longitudinal momentum resolution. The total time resolution was 540 ps (FWHM). We measured two samples: a gold foil and a carbon tape at a positron implantation energy of 2 keV. For each sample discrete electron momentum states and their respective positron lifetimes were extracted.

Nanoscale deformation analysis with high-resolution transmission electron microscopy and digital image correlation

DOE PAGES

Wang, Xueju; Pan, Zhipeng; Fan, Feifei; ...

2015-09-10

We present an application of the digital image correlation (DIC) method to high-resolution transmission electron microscopy (HRTEM) images for nanoscale deformation analysis. The combination of DIC and HRTEM offers both the ultrahigh spatial resolution and high displacement detection sensitivity that are not possible with other microscope-based DIC techniques. We demonstrate the accuracy and utility of the HRTEM-DIC technique through displacement and strain analysis on amorphous silicon. Two types of error sources resulting from the transmission electron microscopy (TEM) image noise and electromagnetic-lens distortions are quantitatively investigated via rigid-body translation experiments. The local and global DIC approaches are applied for themore » analysis of diffusion- and reaction-induced deformation fields in electrochemically lithiated amorphous silicon. As a result, the DIC technique coupled with HRTEM provides a new avenue for the deformation analysis of materials at the nanometer length scales.« less

Sub-Millisecond Time Resolved X-ray Surface Diffraction During Pulsed Laser Deposition

NASA Astrophysics Data System (ADS)

Tischler, J. Z.; Larson, B. C.; Eres, Gyula; Rouleau, C. M.; Lowndes, D. H.; Yoon, M.; Zschack, P.

2001-03-01

The initial crystallization and evolution of the SrTiO3 (001) surface during homoeptaxial pulsed laser deposition growth of SrTiO3 was studied using time resolved surface x-ray diffraction with a time resolution down to 200 μ s. Measurements performed at the UNICAT undulator line at the Advanced Photon Source indicated prompt formation of epitaxial SrTiO3 bi-layers down to our limiting time resolution. The subsequent evolution of the surface occurred on a much greater time scale, and was studied both by measurements of surface truncation rod intensities and by measurements of diffuse scattering near the rod. The effect of temperature and correlation with in-plane order will also be discussed.

Spring green-up date derived from GIMMS3g and SPOT-VGT NDVI of winter wheat cropland in the North China Plain

NASA Astrophysics Data System (ADS)

Liu, Zhengjia; Wu, Chaoyang; Liu, Yansui; Wang, Xiaoyue; Fang, Bin; Yuan, Wenping; Ge, Quansheng

2017-08-01

Satellite temporal resolution affects the fitting accuracy of vegetation growth curves. However, there are few studies that evaluate the impact of different satellite data (including temporal resolution and time series change) on spring green-up date (GUD) extraction. In this study, four GUD algorithms and two different temporal resolution satellite data (GIMMS3g during 1982-2013 and SPOT-VGT during 1999-2013) were used to investigate winter wheat GUD in the North China Plain. Four GUD algorithms included logistic-NDVI (normalized difference vegetation index), logistic-cumNDVI (cumulative NDVI), polynomial-NDVI and polynomial-cumNDVI algorithms. All algorithms and data were first regrouped into eight controlled cases. At site scale, we evaluated the performance of each case using correlation coefficient (r), bias and root mean square error (RMSE). We further compared spatial patterns and inter-annual trends of GUD inferred from different algorithms, and then analyzed the difference between GIMMS3g-based GUD and SPOT-VGT-based GUD. Our results showed that all satellite-based GUD were correlated with observations with r ranging from 0.32 to 0.57 (p < 0.01). SPOT-VGT-based GUD generally had better correlations with observed GUD than those of GIMMS3g. Spatially, SPOT-VGT-based GUD performed more reasonable spatial distributions. Inter-annual regional averaged satellite-based GUD presented overall advanced trends during 1982-2013 (0.3-2.0 days/decade) while delayed trends were observed during 1999-2013 (1.7-7.4 days/decade for GIMMS3g and 3.8-7.4 days/decade for SPOT-VGT). However, their significance levels were highly dependent on the data and algorithms used. Our findings suggest cautions on previous results of inter-annual variability of phenology from a single data/method.

An integrated bio-chemostratigraphic framework for Lower Cretaceous (Barremian-Cenomanian) shallow-water carbonates of the Central Apennines (Italy)

NASA Astrophysics Data System (ADS)

Schmitt, Katharina; Heimhofer, Ulrich; Frijia, Gianluca; Huck, Stefan

2017-04-01

Shallow-water carbonate platform sections are valuable archives for the reconstruction of deep-time environmental and climatic conditions, but the biostratigraphic resolution is often rather low. Moreover, chemostratigraphic correlation with well-dated pelagic sections by means of bulk carbonate carbon-isotope stratigraphy is notoriously difficult and afflicted with large uncertainties, as shallow-water sections are particularly prone to the impact of diagenesis. In the current study, an integrated biostratigraphic-chemostratigraphic approach is applied to southern Tethyan Lower Cretaceous carbonate platform deposits (Santa Lucia, Monte La Costa sections) situated in the Central Apennines in Italy. The 500 m thick Santa Lucia section, representing an open lagoonal inner carbonate platform setting, provides a characteristic carbon- and oxygen-isotope pattern that allows for correlation with pelagic composite reference curves (Vocontian and Umbria Marche basins). Calibrated by means of foraminiferal biostratigraphy and rudist bivalve strontium-isotope stratigraphy, the section serves as local chemostratigraphic shallow-water reference for the Barremian to Cenomanian. The 250 m thick Monte La Costa section comprises predominantly coarse grained (biostromal) and often strongly cemented shelf margin deposits. Although benthic foraminifera are scarce and the carbonates evidently suffered strong diagenetic alteration, high-resolution (rudist shell) strontium-isotope stratigraphy in combination with superimposed carbon-isotope trends and biological-lithological changes (e.g., mass occurrences of Bacinella irregularis s.l) enables correlation with the Early Albian to Cenomanian portion of the Santa Lucia reference section. At both localities, chemostratigraphy indicates a major gap covering large parts of the Lower and middle Cenomanian. After having considerably improved the stratigraphic resolution of the studied sections, selected best-preserved rudist shells are going to be used for sclerochronological investigations. This will allow reconstructing the impact of long-term (Myr) and short-term (seasonal) paleoclimatic and paleoenvironmental changes on Cretaceous shallow seas.

Seismic tomography of Basse-Terre volcanic island, Guadeloupe, Lesser Antilles, using earthquake travel times and noise correlations

NASA Astrophysics Data System (ADS)

Barnoud, Anne; Coutant, Olivier; Bouligand, Claire; Massin, Frédérick; Stehly, Laurent

2015-04-01

We image the volcanic island of Basse-Terre, Guadeloupe, Lesser Antilles, using both earthquake travel times and noise correlations. (1) A new earthquake catalog was recently compiled for the Lesser Antilles by the CDSA/OVSG/IPGP (Massin et al., EGU General Assembly 2014) and allows us to perform classical travel time tomography to obtain smooth 3D body wave velocity models. The geometrical configuration of the volcanic arc controls the resolution of the model in our zone of interest. (2) Surface wave tomography using noise correlations was successfully applied to volcanoes (Brenguier et al., Geophys. Res. Lett. 2007). We use seismic noise recorded at 16 broad-band stations and 9 short-period stations from Basse-Terre over a period of six years (2007-2012). For each station pair, we extract a dispersion curve from the noise correlation to get surface wave velocity models. The inversion of the dispersion curves produces a 3D S-wave velocity model of the island. The spatial distribution of seismic stations accross the island is highly heterogeneous, leading to higher resolution near the dome of the Soufrière of Guadeloupe volcano. Resulting velocity models are compared with densities obtained by 3D inversion of gravimetric data (Barnoud et al., AGU Fall Meeting 2013). Further work should include simultaneous inversion of seismic and gravimetric datasets to overcome resolution limitations.

Wildfires Dynamics in Siberian Larch Forests

NASA Technical Reports Server (NTRS)

Ponomarev, Evgenii I.; Kharuk, Viacheslav I.; Ranson, Kenneth J.

2016-01-01

Wildfire number and burned area temporal dynamics within all of Siberia and along a south-north transect in central Siberia (45deg-73degN) were studied based on NOAA/AVHRR (National Oceanic and Atmospheric Administration/ Advanced Very High Resolution Radiometer) and Terra/MODIS (Moderate Resolution Imaging Spectroradiometer) data and field measurements for the period 1996-2015. In addition, fire return interval (FRI) along the south-north transect was analyzed. Both the number of forest fires and the size of the burned area increased during recent decades (p < 0.05). Significant correlations were found between forest fires, burned areas and air temperature (r = 0.5) and drought index (The Standardized Precipitation Evapotranspiration Index, SPEI) (r = 0.43). Within larch stands along the transect, wildfire frequency was strongly correlated with incoming solar radiation (r = 0.91). Fire danger period length decreased linearly from south to north along the transect. Fire return interval increased from 80 years at 62 N to 200 years at the Arctic Circle (6633' N), and to about 300 years near the northern limit of closed forest stands (about 71+ N). That increase was negatively correlated with incoming solar radiation (r = 0.95). Keywords: wildfires; drought index; larch stands; fire return interval; fire frequency; burned area; climate-induced trends in Siberian wildfires

Electrodeposition and Screening of Photoelectrochemical Activity in Conjugated Polymers Using Scanning Electrochemical Cell Microscopy.

PubMed

Aaronson, Barak D B; Garoz-Ruiz, Jesus; Byers, Joshua C; Colina, Alvaro; Unwin, Patrick R

2015-11-24

A number of renewable energy systems require an understanding and correlation of material properties and photoelectrochemical activity on the micro to nanoscale. Among these, conducting polymer electrodes continue to be important materials. In this contribution, an ultrasensitive scanning electrochemical cell microscopy (SECCM) platform is used to electrodeposit microscale thin films of poly(3-hexylthiophene) (P3HT) on an optically transparent gold electrode and to correlate the morphology (film thickness and structural order) with photoactivity. The electrochemical growth of P3HT begins with a thin ordered film up to 10 nm thick, after which a second more disordered film is deposited, as revealed by micro-Raman spectroscopy. A decrease in photoactivity for the thicker films, measured in situ immediately following film deposition, is attributed to an increase in bulk film disorder that limits charge transport. Higher resolution ex situ SECCM phototransient measurements, using a smaller diameter probe, show local variations in photoactivity within a given deposit. Even after aging, thinner, more ordered regions within a deposit exhibit sustained enhanced photocurrent densities compared to areas where the film is thicker and more disordered. The platform opens up new possibilities for high-throughput combinatorial correlation studies, by allowing materials fabrication and high spatial resolution probing of processes in photoelectrochemical materials.

Auto Correlation Analysis of Coda Waves from Local Earthquakes for Detecting Temporal Changes in Shallow Subsurface Structures: the 2011 Tohoku-Oki, Japan Earthquake

NASA Astrophysics Data System (ADS)

Nakahara, Hisashi

2015-02-01

For monitoring temporal changes in subsurface structures I propose to use auto correlation functions of coda waves from local earthquakes recorded at surface receivers, which probably contain more body waves than surface waves. Use of coda waves requires earthquakes resulting in decreased time resolution for monitoring. Nonetheless, it may be possible to monitor subsurface structures in sufficient time resolutions in regions with high seismicity. In studying the 2011 Tohoku-Oki, Japan earthquake (Mw 9.0), for which velocity changes have been previously reported, I try to validate the method. KiK-net stations in northern Honshu are used in this analysis. For each moderate earthquake normalized auto correlation functions of surface records are stacked with respect to time windows in the S-wave coda. Aligning the stacked, normalized auto correlation functions with time, I search for changes in phases arrival times. The phases at lag times of <1 s are studied because changes at shallow depths are focused. Temporal variations in the arrival times are measured at the stations based on the stretching method. Clear phase delays are found to be associated with the mainshock and to gradually recover with time. The amounts of the phase delays are 10 % on average with the maximum of about 50 % at some stations. The deconvolution analysis using surface and subsurface records at the same stations is conducted for validation. The results show the phase delays from the deconvolution analysis are slightly smaller than those from the auto correlation analysis, which implies that the phases on the auto correlations are caused by larger velocity changes at shallower depths. The auto correlation analysis seems to have an accuracy of about several percent, which is much larger than methods using earthquake doublets and borehole array data. So this analysis might be applicable in detecting larger changes. In spite of these disadvantages, this analysis is still attractive because it can be applied to many records on the surface in regions where no boreholes are available.

GPUs benchmarking in subpixel image registration algorithm

NASA Astrophysics Data System (ADS)

Sanz-Sabater, Martin; Picazo-Bueno, Jose Angel; Micó, Vicente; Ferrerira, Carlos; Granero, Luis; Garcia, Javier

2015-05-01

Image registration techniques are used among different scientific fields, like medical imaging or optical metrology. The straightest way to calculate shifting between two images is using the cross correlation, taking the highest value of this correlation image. Shifting resolution is given in whole pixels which cannot be enough for certain applications. Better results can be achieved interpolating both images, as much as the desired resolution we want to get, and applying the same technique described before, but the memory needed by the system is significantly higher. To avoid memory consuming we are implementing a subpixel shifting method based on FFT. With the original images, subpixel shifting can be achieved multiplying its discrete Fourier transform by a linear phase with different slopes. This method is high time consuming method because checking a concrete shifting means new calculations. The algorithm, highly parallelizable, is very suitable for high performance computing systems. GPU (Graphics Processing Unit) accelerated computing became very popular more than ten years ago because they have hundreds of computational cores in a reasonable cheap card. In our case, we are going to register the shifting between two images, doing the first approach by FFT based correlation, and later doing the subpixel approach using the technique described before. We consider it as `brute force' method. So we will present a benchmark of the algorithm consisting on a first approach (pixel resolution) and then do subpixel resolution approaching, decreasing the shifting step in every loop achieving a high resolution in few steps. This program will be executed in three different computers. At the end, we will present the results of the computation, with different kind of CPUs and GPUs, checking the accuracy of the method, and the time consumed in each computer, discussing the advantages, disadvantages of the use of GPUs.

Single-view 3D reconstruction of correlated gamma-neutron sources

DOE PAGES

Monterial, Mateusz; Marleau, Peter; Pozzi, Sara A.

2017-01-05

We describe a new method of 3D image reconstruction of neutron sources that emit correlated gammas (e.g. Cf- 252, Am-Be). This category includes a vast majority of neutron sources important in nuclear threat search, safeguards and non-proliferation. Rather than requiring multiple views of the source this technique relies on the source’s intrinsic property of coincidence gamma and neutron emission. As a result only a single-view measurement of the source is required to perform the 3D reconstruction. In principle, any scatter camera sensitive to gammas and neutrons with adequate timing and interaction location resolution can perform this reconstruction. Using a neutronmore » double scatter technique, we can calculate a conical surface of possible source locations. By including the time to a correlated gamma we further constrain the source location in three-dimensions by solving for the source-to-detector distance along the surface of said cone. As a proof of concept we applied these reconstruction techniques on measurements taken with the the Mobile Imager of Neutrons for Emergency Responders (MINER). Two Cf-252 sources measured at 50 and 60 cm from the center of the detector were resolved in their varying depth with average radial distance relative resolution of 26%. To demonstrate the technique’s potential with an optimized system we simulated the measurement in MCNPX-PoliMi assuming timing resolution of 200 ps (from 2 ns in the current system) and source interaction location resolution of 5 mm (from 3 cm). Furthermore, these simulated improvements in scatter camera performance resulted in radial distance relative resolution decreasing to an average of 11%.« less

Single-view 3D reconstruction of correlated gamma-neutron sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Monterial, Mateusz; Marleau, Peter; Pozzi, Sara A.

We describe a new method of 3D image reconstruction of neutron sources that emit correlated gammas (e.g. Cf- 252, Am-Be). This category includes a vast majority of neutron sources important in nuclear threat search, safeguards and non-proliferation. Rather than requiring multiple views of the source this technique relies on the source’s intrinsic property of coincidence gamma and neutron emission. As a result only a single-view measurement of the source is required to perform the 3D reconstruction. In principle, any scatter camera sensitive to gammas and neutrons with adequate timing and interaction location resolution can perform this reconstruction. Using a neutronmore » double scatter technique, we can calculate a conical surface of possible source locations. By including the time to a correlated gamma we further constrain the source location in three-dimensions by solving for the source-to-detector distance along the surface of said cone. As a proof of concept we applied these reconstruction techniques on measurements taken with the the Mobile Imager of Neutrons for Emergency Responders (MINER). Two Cf-252 sources measured at 50 and 60 cm from the center of the detector were resolved in their varying depth with average radial distance relative resolution of 26%. To demonstrate the technique’s potential with an optimized system we simulated the measurement in MCNPX-PoliMi assuming timing resolution of 200 ps (from 2 ns in the current system) and source interaction location resolution of 5 mm (from 3 cm). Furthermore, these simulated improvements in scatter camera performance resulted in radial distance relative resolution decreasing to an average of 11%.« less

Search for correlations between the arrival directions of IceCube neutrino events and ultrahigh-energy cosmic rays detected by the Pierre Auger Observatory and the Telescope Array

DOE Office of Scientific and Technical Information (OSTI.GOV)

IceCube Collaboration; Pierre Auger Collaboration; Telescope Array Collaboration

2016-01-01

This paper presents the results of different searches for correlations between very high-energy neutrino candidates detected by IceCube and the highest-energy cosmic rays measured by the Pierre Auger Observatory and the Telescope Array. We first consider samples of cascade neutrino events and of high-energy neutrino-induced muon tracks, which provided evidence for a neutrino flux of astrophysical origin, and study their cross-correlation with the ultrahigh-energy cosmic ray (UHECR) samples as a function of angular separation. We also study their possible directional correlations using a likelihood method stacking the neutrino arrival directions and adopting different assumptions on the size of the UHECRmore » magnetic deflections. Finally, we perform another likelihood analysis stacking the UHECR directions and using a sample of through-going muon tracks optimized for neutrino point-source searches with sub-degree angular resolution. No indications of correlations at discovery level are obtained for any of the searches performed. The smallest of the p-values comes from the search for correlation between UHECRs with IceCube high-energy cascades, a result that should continue to be monitored.« less

Can Seismic Observations of Bed Conditions on Ice Streams Help Constrain Parameters in Ice Flow Models?

NASA Astrophysics Data System (ADS)

Kyrke-Smith, Teresa M.; Gudmundsson, G. Hilmar; Farrell, Patrick E.

2017-11-01

We investigate correlations between seismically derived estimates of basal acoustic impedance and basal slipperiness values obtained from a surface-to-bed inversion using a Stokes ice flow model. Using high-resolution measurements along several seismic profiles on Pine Island Glacier (PIG), we find no significant correlation at kilometer scale between acoustic impedance and either retrieved basal slipperiness or basal drag. However, there is a stronger correlation when comparing average values along the individual profiles. We hypothesize that the correlation appears at the length scales over which basal variations are important to large-scale ice sheet flow. Although the seismic technique is sensitive to the material properties of the bed, at present there is no clear way of incorporating high-resolution seismic measurements of bed properties on ice streams into ice flow models. We conclude that more theoretical work needs to be done before constraints on mechanical conditions at the ice-bed interface from acoustic impedance measurements can be of direct use to ice sheet models.

High spatial resolution correlated investigation of Zn segregation to stacking faults in ZnTe/CdSe nanostructures

NASA Astrophysics Data System (ADS)

Bonef, Bastien; Grenier, Adeline; Gerard, Lionel; Jouneau, Pierre-Henri; André, Regis; Blavette, Didier; Bougerol, Catherine

2018-02-01

The correlative use of atom probe tomography (APT) and energy dispersive x-ray spectroscopy in scanning transmission electron microscopy (STEM) allows us to characterize the structure of ZnTe/CdSe superlattices at the nanometre scale. Both techniques reveal the segregation of zinc along [111] stacking faults in CdSe layers, which is interpreted as a manifestation of the Suzuki effect. Quantitative measurements reveal a zinc enrichment around 9 at. % correlated with a depletion of cadmium in the stacking faults. Raw concentration data were corrected so as to account for the limited spatial resolution of both STEM and APT techniques. A simple calculation reveals that the stacking faults are almost saturated in Zn atoms (˜66 at. % of Zn) at the expense of Cd that is depleted.

Ocean wavenumber estimation from wave-resolving time series imagery

USGS Publications Warehouse

Plant, N.G.; Holland, K.T.; Haller, M.C.

2008-01-01

We review several approaches that have been used to estimate ocean surface gravity wavenumbers from wave-resolving remotely sensed image sequences. Two fundamentally different approaches that utilize these data exist. A power spectral density approach identifies wavenumbers where image intensity variance is maximized. Alternatively, a cross-spectral correlation approach identifies wavenumbers where intensity coherence is maximized. We develop a solution to the latter approach based on a tomographic analysis that utilizes a nonlinear inverse method. The solution is tolerant to noise and other forms of sampling deficiency and can be applied to arbitrary sampling patterns, as well as to full-frame imagery. The solution includes error predictions that can be used for data retrieval quality control and for evaluating sample designs. A quantitative analysis of the intrinsic resolution of the method indicates that the cross-spectral correlation fitting improves resolution by a factor of about ten times as compared to the power spectral density fitting approach. The resolution analysis also provides a rule of thumb for nearshore bathymetry retrievals-short-scale cross-shore patterns may be resolved if they are about ten times longer than the average water depth over the pattern. This guidance can be applied to sample design to constrain both the sensor array (image resolution) and the analysis array (tomographic resolution). ?? 2008 IEEE.

Diverse protocols for correlative super-resolution fluorescence imaging and electron microscopy of chemically fixed samples

PubMed Central

Kopek, Benjamin G.; Paez-Segala, Maria G.; Shtengel, Gleb; Sochacki, Kem A.; Sun, Mei G.; Wang, Yalin; Xu, C. Shan; van Engelenburg, Schuyler B.; Taraska, Justin W.; Looger, Loren L.; Hess, Harald F.

2017-01-01

Our groups have recently developed related approaches for sample preparation for super-resolution imaging within endogenous cellular environments using correlative light and electron microscopy (CLEM). Four distinct techniques for preparing and acquiring super-resolution CLEM datasets on aldehyde-fixed specimens are provided, including Tokuyasu cryosectioning, whole-cell mount, cell unroofing and platinum replication, and resin embedding and sectioning. Choice of the best protocol for a given application depends on a number of criteria that are discussed in detail. Tokuyasu cryosectioning is relatively rapid but is limited to small, delicate specimens. Whole-cell mount has the simplest sample preparation but is restricted to surface structures. Cell unroofing and platinum replica creates high-contrast, 3-dimensional images of the cytoplasmic surface of the plasma membrane, but is more challenging than whole-cell mount. Resin embedding permits serial sectioning of large samples, but is limited to osmium-resistant probes, and is technically difficult. Expected results from these protocols include super-resolution localization (~10–50 nm) of fluorescent targets within the context of electron microscopy ultrastructure, which can help address cell biological questions. These protocols can be completed in 2–7 days, are compatible with a number of super-resolution imaging protocols, and are broadly applicable across biology. PMID:28384138

Developmental improvements in the resolution and capacity of visual working memory share a common source

PubMed Central

Simmering, Vanessa R.; Miller, Hilary E.

2016-01-01

The nature of visual working memory (VWM) representations is currently a source of debate between characterizations as slot-like versus a flexibly-divided pool of resources. Recently, a dynamic neural field model has been proposed as an alternative account that focuses more on the processes by which VWM representations are formed, maintained, and used in service of behavior. This dynamic model has explained developmental increases in VWM capacity and resolution through strengthening excitatory and inhibitory connections. Simulations of developmental improvements in VWM resolution suggest that one important change is the accuracy of comparisons between items held in memory and new inputs. Thus, the ability to detect changes is a critical component of developmental improvements in VWM performance across tasks, leading to the prediction that capacity and resolution should correlate during childhood. Comparing 5- to 8-year-old children’s performance across color discrimination and change detection tasks revealed the predicted correlation between estimates of VWM capacity and resolution, supporting the hypothesis that increasing connectivity underlies improvements in VWM during childhood. These results demonstrate the importance of formalizing the processes that support the use of VWM, rather than focusing solely on the nature of representations. We conclude by considering our results in the broader context of VWM development. PMID:27329264

Satellite remote sensing of fine particulate air pollutants over Indian mega cities

NASA Astrophysics Data System (ADS)

Sreekanth, V.; Mahesh, B.; Niranjan, K.

2017-11-01

In the backdrop of the need for high spatio-temporal resolution data on PM2.5 mass concentrations for health and epidemiological studies over India, empirical relations between Aerosol Optical Depth (AOD) and PM2.5 mass concentrations are established over five Indian mega cities. These relations are sought to predict the surface PM2.5 mass concentrations from high resolution columnar AOD datasets. Current study utilizes multi-city public domain PM2.5 data (from US Consulate and Embassy's air monitoring program) and MODIS AOD, spanning for almost four years. PM2.5 is found to be positively correlated with AOD. Station-wise linear regression analysis has shown spatially varying regression coefficients. Similar analysis has been repeated by eliminating data from the elevated aerosol prone seasons, which has improved the correlation coefficient. The impact of the day to day variability in the local meteorological conditions on the AOD-PM2.5 relationship has been explored by performing a multiple regression analysis. A cross-validation approach for the multiple regression analysis considering three years of data as training dataset and one-year data as validation dataset yielded an R value of ∼0.63. The study was concluded by discussing the factors which can improve the relationship.

An Efficient Local Correlation Matrix Decomposition Approach for the Localization Implementation of Ensemble-Based Assimilation Methods

NASA Astrophysics Data System (ADS)

Zhang, Hongqin; Tian, Xiangjun

2018-04-01

Ensemble-based data assimilation methods often use the so-called localization scheme to improve the representation of the ensemble background error covariance (Be). Extensive research has been undertaken to reduce the computational cost of these methods by using the localized ensemble samples to localize Be by means of a direct decomposition of the local correlation matrix C. However, the computational costs of the direct decomposition of the local correlation matrix C are still extremely high due to its high dimension. In this paper, we propose an efficient local correlation matrix decomposition approach based on the concept of alternating directions. This approach is intended to avoid direct decomposition of the correlation matrix. Instead, we first decompose the correlation matrix into 1-D correlation matrices in the three coordinate directions, then construct their empirical orthogonal function decomposition at low resolution. This procedure is followed by the 1-D spline interpolation process to transform the above decompositions to the high-resolution grid. Finally, an efficient correlation matrix decomposition is achieved by computing the very similar Kronecker product. We conducted a series of comparison experiments to illustrate the validity and accuracy of the proposed local correlation matrix decomposition approach. The effectiveness of the proposed correlation matrix decomposition approach and its efficient localization implementation of the nonlinear least-squares four-dimensional variational assimilation are further demonstrated by several groups of numerical experiments based on the Advanced Research Weather Research and Forecasting model.

The snake geothermal drilling project. Innovative approaches to geothermal exploration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shervais, John W.; Evans, James P.; Liberty, Lee M.

2014-02-21

The goal of our project was to test innovative technologies using existing and new data, and to ground-truth these technologies using slim-hole core technology. The slim-hole core allowed us to understand subsurface stratigraphy and alteration in detail, and to correlate lithologies observed in core with surface based geophysical studies. Compiled data included geologic maps, volcanic vent distribution, structural maps, existing well logs and temperature gradient logs, groundwater temperatures, and geophysical surveys (resistivity, magnetics, gravity). New data included high-resolution gravity and magnetic surveys, high-resolution seismic surveys, three slimhole test wells, borehole wireline logs, lithology logs, water chemistry, alteration mineralogy, fracture distribution,more » and new thermal gradient measurements.« less

High-resolution stratigraphy with strontium isotopes.

PubMed

Depaolo, D J; Ingram, B L

1985-02-22

The isotopic ratio of strontium-87 to strontium-86 shows no detectable variation in present-day ocean water but changes slowly over millions of years. The strontium contained in carbonate shells of marine organisms records the ratio of strontium-87 to strontium-86 of the oceans at the time that the shells form. Sedimentary rocks composed of accumulated fossil carbonate shells can be dated and correlated with the use of high precision measurements of the ratio of strontium-87 to strontium-86 with a resolution that is similar to that of other techniques used in age correlation. This method may prove valuable for many geological, paleontological, paleooceanographic, and geochemical problems.

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

PubMed Central

Mägi, Reedik; Horikoshi, Momoko; Sofer, Tamar; Mahajan, Anubha; Kitajima, Hidetoshi; Franceschini, Nora; McCarthy, Mark I.; Morris, Andrew P.

2017-01-01

Abstract Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse populations can increase power to detect complex trait loci when the underlying causal variants are shared between ancestry groups. However, heterogeneity in allelic effects between GWAS at these loci can occur that is correlated with ancestry. Here, a novel approach is presented to detect SNP association and quantify the extent of heterogeneity in allelic effects that is correlated with ancestry. We employ trans-ethnic meta-regression to model allelic effects as a function of axes of genetic variation, derived from a matrix of mean pairwise allele frequency differences between GWAS, and implemented in the MR-MEGA software. Through detailed simulations, we demonstrate increased power to detect association for MR-MEGA over fixed- and random-effects meta-analysis across a range of scenarios of heterogeneity in allelic effects between ethnic groups. We also demonstrate improved fine-mapping resolution, in loci containing a single causal variant, compared to these meta-analysis approaches and PAINTOR, and equivalent performance to MANTRA at reduced computational cost. Application of MR-MEGA to trans-ethnic GWAS of kidney function in 71,461 individuals indicates stronger signals of association than fixed-effects meta-analysis when heterogeneity in allelic effects is correlated with ancestry. Application of MR-MEGA to fine-mapping four type 2 diabetes susceptibility loci in 22,086 cases and 42,539 controls highlights: (i) strong evidence for heterogeneity in allelic effects that is correlated with ancestry only at the index SNP for the association signal at the CDKAL1 locus; and (ii) 99% credible sets with six or fewer variants for five distinct association signals. PMID:28911207

Intrathecal expression of IL-5 and humoral response in patients with tick-borne encephalitis.

PubMed

Grygorczuk, Sambor; Czupryna, Piotr; Pancewicz, Sławomir; Świerzbińska, Renata; Kondrusik, Maciej; Dunaj, Justyna; Zajkowska, Joanna; Moniuszko-Malinowska, Anna

2018-05-01

The aim of the study was to assess the role of an early specific humoral response in human infection with a tick-borne encephalitis virus (TBEV) and the role of IL-5 as its potential mediator and marker. The retrospective study involved a cohort of 199 patients diagnosed with TBE, in whom anti-TBEV IgM and IgG antibody titers were analyzed on admission and compared with clinical presentation and basic laboratory parameters. The prospective study included 50 TBE patients in whom IL-5 serum and CSF concentration was measured with ELISA on admission in the TBE neurologic phase and in selected patients before discharge, at follow-up or in samples obtained before the neurologic phase onset. The serum anti-TBEV IgM correlated with good clinical outcome and the CSF anti-TBEV IgM with more pronounced CSF inflammation on admission, but also with its more complete resolution on follow-up. The serum anti-TBEV IgG correlated with milder presentation and better outcome. Concentration of IL-5 was increased in CSF but not in the serum of TBE patients. IL-5 concentration index on admission favored its intrathecal synthesis. IL-5 did not correlate significantly with clinical presentation and specific IgM and IgG titers. Specific anti-TBEV IgM systemic and intrathecal response and IgG systemic response are protective, together favoring milder presentation, better outcome and resolution of central nervous system (CNS) inflammation. IL-5 is expressed intrathecally in TBE, but its pathogenetic role remains unclear. Copyright © 2018 Elsevier GmbH. All rights reserved.

The Effects of Bolus Volume and Texture on Pharyngeal Pressure Events Using High-resolution Manometry and Its Comparison with Videofluoroscopic Swallowing Study

PubMed Central

Ryu, Ju Seok; Park, Donghwi; Oh, Yoongul; Lee, Seok Tae; Kang, Jin Young

2016-01-01

Background/Aims The purpose of this study was to develop new parameters of high-resolution manometry (HRM) and to applicate these to quantify the effect of bolus volume and texture on pharyngeal swallowing. Methods Ten healthy subjects prospectively swallowed dry, thin fluid 2 mL, thin fluid 5 mL, thin fluid 10 mL, and drinking twice to compare effects of bolus volume. To compare effect of texture, subjects swallowed thin fluid 5 mL, yogurt 5 mL, and bread twice. A 32-sensor HRM catheter and BioVIEW ANALYSIS software were used for data collection and analysis. HRM data were synchronized with kinematic analysis of videofluoroscopic swallowing study (VFSS) using epiglottis tilting. Results Linear correlation analysis for volume showed significant correlation for area of velopharynx, duration of velopharynx, pre-upper esophageal sphincter (UES) maximal pressure, minimal UES pressure, UES activity time, and nadir UES duration. In the correlation with texture, all parameters were not significantly different. The contraction of the velopharynx was faster than laryngeal elevation. The durations of UES relaxation was shorter in the kinematic analysis than HRM. Conclusions The bolus volume was shown to have significant effect on pharyngeal pressure and timing, but the texture did not show any effect on pharyngeal swallowing. The parameters of HRM were more sensitive than those of kinematic analysis. As the parameters of HRM are based on precise anatomic structure and the kinematic analysis reflects the actions of multiple anatomic structures, HRM and VFSS should be used according to their purposes. PMID:26598598

Study of inelastic decay amplitudes in /sup 51/Mn

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whatley, K.M.

1982-01-01

Detailed angular distribution measurments on inelastically scattered protons and de-excitation ..gamma..-rays in the /sup 50/Cr(p,p') and /sup 50/Cr(p,p'..gamma..) reactions were performed for 107 resonances in /sup 51/Mn in the proton energy range 3.0-4.4 MeV. An overall resolution of 425 eV was obtained with the tandem Van de Graaff accelerator and the high resolution system at the Triangle Universities Nuclear Laboratory. Spin and parity assignments for the 107 resonances studied were as follows: 1/2/sup +/ (4); 1/2/sup -/ (6); 3/2/sup -/ (30); 3/2/sup +/ (20); 5/2/sup +/ (38); 5/2/sup -/ (7); 7/2/sup +/ (1); and 9/2/sup +/ (1). Mixing ratios formore » the inelastic decay amplitudes were uniquely determined for all resonances except those assigned J/sup ..pi../ = 1/2/sup +/, 1/2/sup -/, or 3/2/sup +/. For 1/2/sup +/ and 1/2/sup -/ resonances there is only one open decay channel. For 3/2/sup +/ resonances, insufficient information is obtained from this experiment to determine a unique solution for the mixing ratios. Statistical studies were performed on the set of 3/2/sup -/ resonances and on the set of 5/2/sup +/ resonances. Strong channel-channel correlations were observed in the distributions of the reduced widths and the reduced width amplitudes for 5/2/sup +/ resonances. The existence of such correlations is a violation of the extreme statistical model. The present results agree with the reduced width amplitude distribution of Krieger and Porter which includes channel-channel correlations.« less

Integrating the Holocene tephrostratigraphy for East Asia using a high-resolution cryptotephra study from Lake Suigetsu (SG14 core), central Japan

NASA Astrophysics Data System (ADS)

McLean, Danielle; Albert, Paul G.; Nakagawa, Takeshi; Suzuki, Takehiko; Staff, Richard A.; Yamada, Keitaro; Kitaba, Ikuko; Haraguchi, Tsuyoshi; Kitagawa, Junko; Smith, Victoria C.; SG14 Project Members

2018-03-01

Tephra (volcanic ash) layers have the potential to synchronise disparate palaeoenvironmental archives on regional to hemispheric scales. Highly productive arc regions, like those in East Asia, offer a considerable number of widespread isochrons, but before records can be confidently correlated using these layers, a refined and integrated framework of these eruptive events is required. Here we present the first high-resolution Holocene cryptotephra study in East Asia, using the Lake Suigetsu sedimentary archive in central Japan. The Holocene tephrostratigraphy has been extended from four to twenty ash layers using cryptotephra extraction techniques, which integrates the deposits from explosive eruptions from North Korea/China, South Korea and along the Japanese arc. This Lake Suigetsu tephrostratigraphy is now the most comprehensive record of East Asian volcanism, and the linchpin site for correlating sequences across this region. Major element glass geochemical compositions are presented for the tephra layers in the sequence, which have been compared to proximal datasets to correlate them to their volcanic source and specific eruptions. This study has significantly extended the ash dispersal of many key Holocene marker layers, and has identified the first distal occurrence of isochrons from Ulleungdo and Changbaishan volcanoes. Utilising the high-precision Lake Suigetsu chronology, we are able to provide constrained eruption ages for the tephra layers, which can be transferred into other site-specific age models containing these markers. This new framework indicates that several isochrons stratigraphically bracket abrupt climate intervals in Japan, and could be used to precisely assess the regional and hemispheric synchronicity of these events.

Intracranial arterial wall imaging using three-dimensional high isotropic resolution black blood MRI at 3.0 Tesla.

PubMed

Qiao, Ye; Steinman, David A; Qin, Qin; Etesami, Maryam; Schär, Michael; Astor, Brad C; Wasserman, Bruce A

2011-07-01

To develop a high isotropic-resolution sequence to evaluate intracranial vessels at 3.0 Tesla (T). Thirteen healthy volunteers and 4 patients with intracranial stenosis were imaged at 3.0T using 0.5-mm isotropic-resolution three-dimensional (3D) Volumetric ISotropic TSE Acquisition (VISTA; TSE, turbo spin echo), with conventional 2D-TSE for comparison. VISTA was repeated for 6 volunteers and 4 patients at 0.4-mm isotropic-resolution to explore the trade-off between SNR and voxel volume. Wall signal-to-noise-ratio (SNR(wall) ), wall-lumen contrast-to-noise-ratio (CNR(wall-lumen) ), lumen area (LA), wall area (WA), mean wall thickness (MWT), and maximum wall thickness (maxWT) were compared between 3D-VISTA and 2D-TSE sequences, as well as 3D images acquired at both resolutions. Reliability was assessed by intraclass correlations (ICC). Compared with 2D-TSE measurements, 3D-VISTA provided 58% and 74% improvement in SNR(wall) and CNR(wall-lumen) , respectively. LA, WA, MWT and maxWT from 3D and 2D techniques highly correlated (ICCs of 0.96, 0.95, 0.96, and 0.91, respectively). CNR(wall-lumen) using 0.4-mm resolution VISTA decreased by 27%, compared with 0.5-mm VISTA but with reduced partial-volume-based overestimation of wall thickness. Reliability for 3D measurements was good to excellent. The 3D-VISTA provides SNR-efficient, highly reliable measurements of intracranial vessels at high isotropic-resolution, enabling broad coverage in a clinically acceptable time. Copyright © 2011 Wiley-Liss, Inc.

Understanding Zeeman EIT Noise Correlation Spectra in Buffered Rb Vapor

NASA Astrophysics Data System (ADS)

O'Leary, Shannon; Zheng, Aojie; Crescimanno, Michael

2014-05-01

Noise correlation spectroscopy on systems manifesting Electromagnetically Induced Transparency (EIT) holds promise as a simple, robust method for performing high-resolution spectroscopy used in applications such as EIT-based atomic magnetometry and clocks. During laser light's propagation through a resonant medium, interaction with the medium converts laser phase noise into intensity noise. While this noise conversion can diminish the precision of EIT applications, noise correlation techniques transform the noise into a useful spectroscopic tool that can improve the application's precision. Using a single diode laser with large phase noise, we examine laser intensity noise and noise correlations from Zeeman EIT in a buffered Rb vapor. Of particular interest is a narrow noise correlation feature, resonant with EIT, that has been shown in earlier work to be power-broadening resistant at low powers. We report here on our recent experimental work and complementary theoretical modeling on EIT noise spectra, including a study of power broadening of the narrow noise correlation feature. Understanding the nature of the noise correlation spectrum is essential for optimizing EIT-noise applications.

Novel Super-Resolution Approach to Time-Resolved Volumetric 4-Dimensional Magnetic Resonance Imaging With High Spatiotemporal Resolution for Multi-Breathing Cycle Motion Assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Guang, E-mail: lig2@mskcc.org; Wei, Jie; Kadbi, Mo

Purpose: To develop and evaluate a super-resolution approach to reconstruct time-resolved 4-dimensional magnetic resonance imaging (TR-4DMRI) with a high spatiotemporal resolution for multi-breathing cycle motion assessment. Methods and Materials: A super-resolution approach was developed to combine fast 3-dimensional (3D) cine MRI with low resolution during free breathing (FB) and high-resolution 3D static MRI during breath hold (BH) using deformable image registration. A T1-weighted, turbo field echo sequence, coronal 3D cine acquisition, partial Fourier approximation, and SENSitivity Encoding parallel acceleration were used. The same MRI pulse sequence, field of view, and acceleration techniques were applied in both FB and BH acquisitions;more » the intensity-based Demons deformable image registration method was used. Under an institutional review board–approved protocol, 7 volunteers were studied with 3D cine FB scan (voxel size: 5 × 5 × 5 mm{sup 3}) at 2 Hz for 40 seconds and a 3D static BH scan (2 × 2 × 2 mm{sup 3}). To examine the image fidelity of 3D cine and super-resolution TR-4DMRI, a mobile gel phantom with multi-internal targets was scanned at 3 speeds and compared with the 3D static image. Image similarity among 3D cine, 4DMRI, and 3D static was evaluated visually using difference image and quantitatively using voxel intensity correlation and Dice index (phantom only). Multi-breathing-cycle waveforms were extracted and compared in both phantom and volunteer images using the 3D cine as the references. Results: Mild imaging artifacts were found in the 3D cine and TR-4DMRI of the mobile gel phantom with a Dice index of >0.95. Among 7 volunteers, the super-resolution TR-4DMRI yielded high voxel-intensity correlation (0.92 ± 0.05) and low voxel-intensity difference (<0.05). The detected motion differences between TR-4DMRI and 3D cine were −0.2 ± 0.5 mm (phantom) and −0.2 ± 1.9 mm (diaphragms). Conclusion: Super-resolution TR-4DMRI has been reconstructed with adequate temporal (2 Hz) and spatial (2 × 2 × 2 mm{sup 3}) resolutions. Further TR-4DMRI characterization and improvement are necessary before clinical applications. Multi-breathing cycles can be examined, providing patient-specific breathing irregularities and motion statistics for future 4D radiation therapy.« less

High Concentrations of Hydrogen-bearing Volatiles at the Base of Poleward-facing slopes in the Moon's Large Southern Permanently Shadowed Regions.

NASA Astrophysics Data System (ADS)

McClanahan, T. P.; Mitrofanov, I. G.; Boynton, W. V.; Chin, G.; Livengood, T. A.; Litvak, M. L.; Sanin, A. B.; Starr, R. D.

2016-12-01

In this paper we review evidence that indicates that high concentrations of hydrogen-bearing volatiles are biased towards the base of poleward-facing slopes (PFS) in the Moon's large southern permanently shadowed regions (PSR). Results are derived from a correlated study of Lunar Reconnaissance Orbiter instrument maps of: epithermal neutron leakage flux observed by the Lunar Exploration Neutron Detector (LEND), topography derived from the Lunar Observing Laser Altimeter (LOLA) and surface thermal maps derived from the Diviner radiometer. Maximum concentrations of hydrogen-volatiles, likely as water ice, are observed in the Cabeus crater's PSR, 0.62 wght% water-equivalent-hydrogen. Detailed studies show that the occurrence of hydrogen-volatiles at the base of the (PFS) are correlated with the locations of low PSR temperatures of Cabeus, Haworth, Shoemaker and Faustini. LEND observations show no consistent correlation to smaller impact craters and the lowest temperatures within the PSR's. It is not presently known if the high volatile concentrations are due to downslope migration or thermal stability in the PFS breaks in slope. 15-km Full-width at Half-Maximum (FWHM) is shown to be an upper-bounds condition for the LEND collimated sensor's spatial resolution, derived from a cross-sectional profile, through the permanently shadowed region at Cabeus'. LEND's high-resolution spatial response is further illustrated in a 220-km long profile cut through the co-aligned permanently shadowed regions and partially-illuminated ridges of Haworth, Shoemaker, Faustini and Amundsen craters.

Spatial-temporal consistency between gross primary productivity and solar-induced chlorophyll fluorescence of vegetation in China during 2007-2014

NASA Astrophysics Data System (ADS)

Ma, J.; Xiao, X.; Zhang, Y.; Chen, B.; Zhao, B.

2017-12-01

Great significance exists in accurately estimating spatial-temporal patterns of gross primary production (GPP) because of its important role in global carbon cycle. Satellite-based light use efficiency (LUE) models are regarded as an efficient tool in simulating spatially time-sires GPP. However, the estimation of the accuracy of GPP simulations from LUE at both spatial and temporal scales is still a challenging work. In this study, we simulated GPP of vegetation in China during 2007-2014 using a LUE model (Vegetation Photosynthesis Model, VPM) based on MODIS (moderate-resolution imaging spectroradiometer) images of 8-day temporal and 500-m spatial resolutions and NCEP (National Center for Environmental Prediction) climate data. Global Ozone Monitoring Instrument 2 (GOME-2) solar-induced chlorophyll fluorescence (SIF) data were used to compare with VPM simulated GPP (GPPVPM) temporally and spatially using linear correlation analysis. Significant positive linear correlations exist between monthly GPPVPM and SIF data over both single year (2010) and multiple years (2007-2014) in China. Annual GPPVPM is significantly positive correlated with SIF (R2>0.43) spatially for all years during 2007-2014 and all seasons in 2010 (R2>0.37). GPP dynamic trends is high spatial-temporal heterogeneous in China during 2007-2014. The results of this study indicate that GPPVPM is temporally and spatially in line with SIF data, and space-borne SIF data have great potential in validating and parameterizing GPP estimation of LUE-based models.

High-resolution manometry classifications for idiopathic achalasia in patients with Chagas' disease esophagopathy.

PubMed

Vicentine, Fernando P P; Herbella, Fernando A M; Allaix, Marco E; Silva, Luciana C; Patti, Marco G

2014-02-01

Idiopathic achalasia (IA) and Chagas' disease esophagopathy (CDE) share several similarities. The comparison between IA and CDE is important to evaluate whether treatment options and their results can be accepted universally. High-resolution manometry (HRM) has proved a better diagnostic tool compared to conventional manometry. This study aims to evaluate HRM classifications for idiopathic achalasia in patients with CDE. We studied 98 patients: 52 patients with CDE (52 % females, mean age, 57 ± 14 years) and 46 patients with IA (54 % females; mean age 48 ± 19 years). All patients underwent a HRM and barium esophagogram. The Chicago classification was distributed in IA as Chicago I, 35 %; Chicago II, 63 %; and Chicago III, 2 %, and in CDE as Chicago I, 52 %; Chicago II, 48 %; and Chicago III, 0 % (p = 0.1, 0.1, and 0.5, respectively). All patients had the classic Rochester type. CDE patients had more pronounced degrees of esophageal dilatation (p < 0.002). The degree of esophageal dilatation did not correlate with Chicago classification (p = 0.08). In nine (9 %) patients, the HRM pattern changed during the test from Chicago I to II. Our results show that (a) HRM classifications for IA can be applied in patients with CDE and (b) HRM classifications did not correlate with the degree of esophageal dilatation. HRM classifications may reflect esophageal repletion and pressurization instead of muscular contraction. The correlation between manometric findings and treatment outcomes for CDE needs to be answered in the near future.

Improving dust emission characterization in dust models using dynamic high-resolution geomorphic erodibility map

NASA Astrophysics Data System (ADS)

Parajuli, S. P.; Yang, Z.; Kocurek, G.

2013-12-01

Dust is known to affect the earth radiation budget, biogeochemical cycle, precipitation, human health and visibility. Despite the increased research effort, dust emission modeling remains challenging because dust emission is affected by complex geomorphological processes. Existing dust models overestimate dust emission and rely on tuning and a static erodibility factor in order to make simulated results comparable to remote sensing and ground-based observations. In most of current models, dust emission is expressed in terms of threshold friction speed, which ultimately depends mainly upon the percentage clay content and soil moisture. Unfortunately, due to the unavailability of accurate and high resolution input data of the clay content and soil moisture, estimated threshold friction speed commonly does not represent the variability in field condition. In this work, we attempt to improve dust emission characterization by developing a high resolution geomorphic map of the Middle East and North Africa (MENA), which is responsible for more than 50% of global dust emission. We develop this geomorphic map by visually examining high resolution satellite images obtained from Google Earth Pro and ESRI base map. Albeit subjective, our technique is more reliable compared to automatic image classification technique because we incorporate knowledge of geological/geographical setting in identifying dust sources. We hypothesize that the erodibility is unique for different geomorphic landforms and that it can be quantified by the correlation between observed wind speed and satellite retrieved aerosol optical depth (AOD). We classify the study area into several key geomorphological categories with respect to their dust emission potential. Then we quantify their dust emission potential using the correlation between observed wind speed and satellite retrieved AOD. The dynamic, high-resolution geomorphic erodibility map thus prepared will help to reduce the uncertainty in current dust models associated with poor characterization of dust sources. The baseline dust scheme used in this study is the Dust Entrainment and Deposition (DEAD) model, which is also a component of the community land model (CLM). Proposed improvements in the dust emission representation will help to better understand the accurate effect of dust on climate processes.

High Grazing Angle and High Resolution Sea Clutter: Correlation and Polarisation Analyses

DTIC Science & Technology

2007-03-01

the azimuthal correlation. The correlation between the HH and VV sea clutter data is low. A CA-CFAR ( cell average constant false-alarm rate...to calculate the power spectra of correlation profiles. The frequency interval of the traditional Discrete Fourier Transform is NT1 Hz, where N and...sea spikes, the Entropy-Alpha decomposition of sea spikes is shown in Figure 30. The process first locates spikes using a cell -average constant false

High-resolution three-dimensional magnetic resonance imaging of mouse lung in situ.

PubMed

Scadeng, Miriam; Rossiter, Harry B; Dubowitz, David J; Breen, Ellen C

2007-01-01

This study establishes a method for high-resolution isotropic magnetic resonance (MR) imaging of mouse lungs using tracheal liquid-instillation to remove MR susceptibility artifacts. C57BL/6J mice were instilled sequentially with perfluorocarbon and phosphate-buffered saline to an airway pressure of 10, 20, or 30 cm H2O. Imaging was performed in a 7T MR scanner using a 2.5-cm Quadrature volume coil and a 3-dimensional (3D) FLASH imaging sequence. Liquid-instillation removed magnetic susceptibility artifacts and allowed lung structure to be viewed at an isotropic resolution of 78-90 microm. Instilled liquid and modeled lung volumes were well correlated (R = 0.92; P < 0.05) and differed by a constant tissue volume (220 +/- 92 microL). 3D image renderings allowed differences in structural dimensions (volumes and areas) to be accurately measured at each inflation pressure. These data demonstrate the efficacy of pulmonary liquid instillation for in situ high-resolution MR imaging of mouse lungs for accurate measurement of pulmonary airway, parenchymal, and vascular structures.

qSR: a quantitative super-resolution analysis tool reveals the cell-cycle dependent organization of RNA Polymerase I in live human cells.

PubMed

Andrews, J O; Conway, W; Cho, W -K; Narayanan, A; Spille, J -H; Jayanth, N; Inoue, T; Mullen, S; Thaler, J; Cissé, I I

2018-05-09

We present qSR, an analytical tool for the quantitative analysis of single molecule based super-resolution data. The software is created as an open-source platform integrating multiple algorithms for rigorous spatial and temporal characterizations of protein clusters in super-resolution data of living cells. First, we illustrate qSR using a sample live cell data of RNA Polymerase II (Pol II) as an example of highly dynamic sub-diffractive clusters. Then we utilize qSR to investigate the organization and dynamics of endogenous RNA Polymerase I (Pol I) in live human cells, throughout the cell cycle. Our analysis reveals a previously uncharacterized transient clustering of Pol I. Both stable and transient populations of Pol I clusters co-exist in individual living cells, and their relative fraction vary during cell cycle, in a manner correlating with global gene expression. Thus, qSR serves to facilitate the study of protein organization and dynamics with very high spatial and temporal resolutions directly in live cell.

An experimental study on the noise correlation properties of CBCT projection data

NASA Astrophysics Data System (ADS)

Zhang, Hua; Ouyang, Luo; Ma, Jianhua; Huang, Jing; Chen, Wufan; Wang, Jing

2014-03-01

In this study, we systematically investigated the noise correlation properties among detector bins of CBCT projection data by analyzing repeated projection measurements. The measurements were performed on a TrueBeam on-board CBCT imaging system with a 4030CB flat panel detector. An anthropomorphic male pelvis phantom was used to acquire 500 repeated projection data at six different dose levels from 0.1 mAs to 1.6 mAs per projection at three fixed angles. To minimize the influence of the lag effect, lag correction was performed on the consecutively acquired projection data. The noise correlation coefficient between detector bin pairs was calculated from the corrected projection data. The noise correlation among CBCT projection data was then incorporated into the covariance matrix of the penalized weighted least-squares (PWLS) criterion for noise reduction of low-dose CBCT. The analyses of the repeated measurements show that noise correlation coefficients are non-zero between the nearest neighboring bins of CBCT projection data. The average noise correlation coefficients for the first- and second- order neighbors are 0.20 and 0.06, respectively. The noise correlation coefficients are independent of the dose level. Reconstruction of the pelvis phantom shows that the PWLS criterion with consideration of noise correlation results in a lower noise level as compared to the PWLS criterion without considering the noise correlation at the matched resolution.

Real-time, high-resolution ultrasonography of the vocal folds—a prospective pilot study in patients before and after thyroidectomy

PubMed Central

Adamczewski, Zbigniew; Brzeziński, Jan; Lewiński, Andrzej

2010-01-01

Purpose The aim of the study was to evaluate the functionality of vocal folds (VF) by real-time, high-resolution ultrasonography (US) and to correlate the imaged features to results of laryngological examination (LE). Methods The study group comprised 50 patients (41 females and nine males), qualified to thyroidectomy. All the patients had LE and US examination before and 2 days, 2 months, and 3 months after the surgery. We used high-resolution US imaging to identify VFs and, subsequently, a pulsed Doppler and Doppler gate to quantify the tissue displacement velocity in the vibrating VF section. Results LE revealed unilateral VF paralysis in two patients. VF dysfunction was diagnosed in other four subjects. In simultaneously performed US examination, changes in VF displacement velocity (VFDV) were observed in ten patients. In two subjects, VFDV was below 30 cm/s— patients with VF paralysis, diagnosed in LE. In a further eight cases, we observed VFDV decrease by 50%, comparing to preoperative values. Both US-imaging and LE, performed after the 3-month follow-up, confirmed the transitional character of the above-mentioned pathologies. Conclusions US imaging of the VFs correlated with LE results, while being a minimally invasive, easily reproducible, and inexpensive method of examining VF functionality. Thanks to many recording options, it may soon become a perfect tool for an early identification of postoperative VF dysfunction with its later monitoring. To our knowledge, it is the first application of US and Doppler gate modes for VFDF quantification; however, an analysis on a larger group of patients is necessary to standardize the technique. PMID:20640934

Towards neural correlates of auditory stimulus processing: A simultaneous auditory evoked potentials and functional magnetic resonance study using an odd-ball paradigm

PubMed Central

Milner, Rafał; Rusiniak, Mateusz; Lewandowska, Monika; Wolak, Tomasz; Ganc, Małgorzata; Piątkowska-Janko, Ewa; Bogorodzki, Piotr; Skarżyński, Henryk

2014-01-01

Background The neural underpinnings of auditory information processing have often been investigated using the odd-ball paradigm, in which infrequent sounds (deviants) are presented within a regular train of frequent stimuli (standards). Traditionally, this paradigm has been applied using either high temporal resolution (EEG) or high spatial resolution (fMRI, PET). However, used separately, these techniques cannot provide information on both the location and time course of particular neural processes. The goal of this study was to investigate the neural correlates of auditory processes with a fine spatio-temporal resolution. A simultaneous auditory evoked potentials (AEP) and functional magnetic resonance imaging (fMRI) technique (AEP-fMRI), together with an odd-ball paradigm, were used. Material/Methods Six healthy volunteers, aged 20–35 years, participated in an odd-ball simultaneous AEP-fMRI experiment. AEP in response to acoustic stimuli were used to model bioelectric intracerebral generators, and electrophysiological results were integrated with fMRI data. Results fMRI activation evoked by standard stimuli was found to occur mainly in the primary auditory cortex. Activity in these regions overlapped with intracerebral bioelectric sources (dipoles) of the N1 component. Dipoles of the N1/P2 complex in response to standard stimuli were also found in the auditory pathway between the thalamus and the auditory cortex. Deviant stimuli induced fMRI activity in the anterior cingulate gyrus, insula, and parietal lobes. Conclusions The present study showed that neural processes evoked by standard stimuli occur predominantly in subcortical and cortical structures of the auditory pathway. Deviants activate areas non-specific for auditory information processing. PMID:24413019

Minority Carrier Lifetime Spectroscopy | Photovoltaic Research | NREL

Science.gov Websites

electronically. It examines the return of photoexcited carriers back to equilibrium as a function of time and time-correlated single-photon counting or time-resolved photoluminescence provides exceptionally fast bandgap materials. The 5-ns time resolution for the µPCD systems (7 and 20 GHz) and ~ 50-ns resolution

Analysis of high-resolution foreign exchange data of USD-JPY for 13 years

NASA Astrophysics Data System (ADS)

Mizuno, Takayuki; Kurihara, Shoko; Takayasu, Misako; Takayasu, Hideki

2003-06-01

We analyze high-resolution foreign exchange data consisting of 20 million data points of USD-JPY for 13 years to report firm statistical laws in distributions and correlations of exchange rate fluctuations. A conditional probability density analysis clearly shows the existence of trend-following movements at time scale of 8-ticks, about 1 min.

A jackknife approach to quantifying single-trial correlation between covariance-based metrics undefined on a single-trial basis.

PubMed

Richter, Craig G; Thompson, William H; Bosman, Conrado A; Fries, Pascal

2015-07-01

The quantification of covariance between neuronal activities (functional connectivity) requires the observation of correlated changes and therefore multiple observations. The strength of such neuronal correlations may itself undergo moment-by-moment fluctuations, which might e.g. lead to fluctuations in single-trial metrics such as reaction time (RT), or may co-fluctuate with the correlation between activity in other brain areas. Yet, quantifying the relation between moment-by-moment co-fluctuations in neuronal correlations is precluded by the fact that neuronal correlations are not defined per single observation. The proposed solution quantifies this relation by first calculating neuronal correlations for all leave-one-out subsamples (i.e. the jackknife replications of all observations) and then correlating these values. Because the correlation is calculated between jackknife replications, we address this approach as jackknife correlation (JC). First, we demonstrate the equivalence of JC to conventional correlation for simulated paired data that are defined per observation and therefore allow the calculation of conventional correlation. While the JC recovers the conventional correlation precisely, alternative approaches, like sorting-and-binning, result in detrimental effects of the analysis parameters. We then explore the case of relating two spectral correlation metrics, like coherence, that require multiple observation epochs, where the only viable alternative analysis approaches are based on some form of epoch subdivision, which results in reduced spectral resolution and poor spectral estimators. We show that JC outperforms these approaches, particularly for short epoch lengths, without sacrificing any spectral resolution. Finally, we note that the JC can be applied to relate fluctuations in any smooth metric that is not defined on single observations. Copyright © 2015. Published by Elsevier Inc.

Recent advances in time series InSAR

NASA Astrophysics Data System (ADS)

Hooper, Andrew; Bekaert, David; Spaans, Karsten

2010-05-01

Despite the multiple successes of InSAR at measuring surface displacement, in many instances the signal over much of an image either decorrelates too quickly to be useful or is swamped by atmospheric noise. Time series InSAR methods seek to address these issues by essentially increasing the signal-to-noise ratio (SNR) through the use of more data. These techniques are particularly useful for applications where the strain rates detected at the surface are low, such as postseismic/interseismic motion, magma/fluid movement, landslides and reservoir exploitation. Our previous developments in this field have included a persistent scatterer algorithm based on spatial correlation, a full resolution small baseline approach based on the same strategy, and procedure for combining the two [Hooper, GRL, 2008]. This combined method works well on small areas (up to one frame) at ERS or Envisat strip-map resolution. However, in applying it to larger areas, such as the Guerrero region of Mexico and western Anatolia in Turkey, or when processing data at higher resolution, e.g. from TerraSAR-X, computer resource problems can arise. We have therefore altered the processing strategy to involve smarter use of computer memory. Further improvement is achieved by the resampling of the selected pixels (whether persistent scatterers or distributed scatterers) to a coarser resolution - usually we do not require a resolution on the scale of individual resolution cells for geophysical applications. Aliasing is avoided by summing the phase of nearby selected pixels, weighted according to their estimated SNR. This is akin to smart multilooking, but note that better results can be achieved than by starting the analysis with low-resolution (multilooked) data. Another development concerns selecting pixels only in images where they appear reliable. This allows for resolution cells that become correlated/decorrelated either in a temporary fashion, e.g., due to snow cover, or in a permanent way due to the appearance or removal of scatterers. The detection algorithm relies on the degree of spatial correlation for the pixel of interest in each image. We have also modified our 3-D phase-unwrapping algorithms to allow for the resulting differing combinations of coherent pixels in every interferogram. We demonstrate our improved techniques on volcanoes in Iceland and the 2006 slow-slip event in Guerrero, Mexico.

A multi-sensor burned area algorithm for crop residue burning in northwestern India: validation and sources of error

NASA Astrophysics Data System (ADS)

Liu, T.; Marlier, M. E.; Karambelas, A. N.; Jain, M.; DeFries, R. S.

2017-12-01

A leading source of outdoor emissions in northwestern India comes from crop residue burning after the annual monsoon (kharif) and winter (rabi) crop harvests. Agricultural burned area, from which agricultural fire emissions are often derived, can be poorly quantified due to the mismatch between moderate-resolution satellite sensors and the relatively small size and short burn period of the fires. Many previous studies use the Global Fire Emissions Database (GFED), which is based on the Moderate Resolution Imaging Spectroradiometer (MODIS) burned area product MCD64A1, as an outdoor fires emissions dataset. Correction factors with MODIS active fire detections have previously attempted to account for small fires. We present a new burned area classification algorithm that leverages more frequent MODIS observations (500 m x 500 m) with higher spatial resolution Landsat (30 m x 30 m) observations. Our approach is based on two-tailed Normalized Burn Ratio (NBR) thresholds, abbreviated as ModL2T NBR, and results in an estimated 104 ± 55% higher burned area than GFEDv4.1s (version 4, MCD64A1 + small fires correction) in northwestern India during the 2003-2014 winter (October to November) burning seasons. Regional transport of winter fire emissions affect approximately 63 million people downwind. The general increase in burned area (+37% from 2003-2007 to 2008-2014) over the study period also correlates with increased mechanization (+58% in combine harvester usage from 2001-2002 to 2011-2012). Further, we find strong correlation between ModL2T NBR-derived burned area and results of an independent survey (r = 0.68) and previous studies (r = 0.92). Sources of error arise from small median landholding sizes (1-3 ha), heterogeneous spatial distribution of two dominant burning practices (partial and whole field), coarse spatio-temporal satellite resolution, cloud and haze cover, and limited Landsat scene availability. The burned area estimates of this study can be used to build a new agricultural fire emissions inventory to re-evaluate the contributions of winter agricultural fires to rural and urban air quality degradation.

Influences of Neural Pathway Integrity on Children's Response to Reading Instruction

PubMed Central

Davis, Nicole; Fan, Qiuyun; Compton, Donald L.; Fuchs, Doug; Fuchs, Lynn S.; Cutting, Laurie E.; Gore, John C.; Anderson, Adam W.

2010-01-01

As the education field moves toward using responsiveness to intervention to identify students with disabilities, an important question is the degree to which this classification can be connected to a student's neurobiological characteristics. A few functional neuroimaging studies have reported a relationship between activation and response to instruction; however, whether a similar correlation exists with white matter (WM) is not clear. To investigate this issue, we acquired high angular resolution diffusion images from a group of first grade children who differed in their levels of responsiveness to a year-long reading intervention. Using probabilistic tractography, we calculated the strength of WM connections among nine cortical regions of interest and correlated these estimates with participants’ scores on four standardized reading measures. We found eight significant correlations, four of which were connections between the insular cortex and angular gyrus. In each of the correlations, a relationship with children's response to intervention was evident. PMID:21088707

Event plane dependence of the flow modulated background in dihadron and jet-hadron correlations in heavy ion collisions

NASA Astrophysics Data System (ADS)

Nattrass, Christine; Todoroki, Takahito

2018-05-01

Dihadron and jet-hadron correlationsare commonly used in relativistic heavy ion collisions to study the soft component of jets in a quark gluon plasma. There is a large correlated background which is described by the Fourier decomposition of the azimuthal anisotropy where vn is the n th order coefficient. The path length dependence of partonic energy loss can be studied by varying the angle of the high momentum trigger particle or jet relative to a reconstructed event plane. This modifies the shape of the background correlated with that event plane. The original derivation of the shape of this background only considered correlations relative to the second-order event plane, which is correlated to the initial participant plane. We derive the shape of this background for an event plane at an arbitrary order. There is a phase shift in the case of jets restricted to asymmetric regions relative to the event plane. For realistic correlations between event planes, the correlation between the second- and fourth-order event planes leads to a much smaller effect than the finite event plane resolution at each order. Finally, we assess the status of the rapidity even v1 term due to flow, which has been measured to be comparable to v2 and v3 terms.

In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation.

PubMed

Lu, Yiming; Liu, Changgeng; Yao, Xincheng

2018-05-01

Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for objective assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its subcellular signal magnitude and fast time course. We report here a virtually structured detection-based super-resolution ophthalmoscope to achieve subcellular spatial resolution and millisecond temporal resolution for in vivo imaging of TRP. Spatiotemporal properties of in vivo TRP were characterized corresponding to variable light intensity stimuli, confirming that TRP is tightly correlated with early stages of phototransduction. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

Covariability of seasonal temperature and precipitation over the Iberian Peninsula in high-resolution regional climate simulations (1001-2099)

NASA Astrophysics Data System (ADS)

Fernández-Montes, S.; Gómez-Navarro, J. J.; Rodrigo, F. S.; García-Valero, J. A.; Montávez, J. P.

2017-04-01

Precipitation and surface temperature are interdependent variables, both as a response to atmospheric dynamics and due to intrinsic thermodynamic relationships and feedbacks between them. This study analyzes the covariability of seasonal temperature (T) and precipitation (P) across the Iberian Peninsula (IP) using regional climate paleosimulations for the period 1001-1990, driven by reconstructions of external forcings. Future climate (1990-2099) was simulated according to SRES scenarios A2 and B2. These simulations enable exploring, at high spatial resolution, robust and physically consistent relationships. In winter, positive P-T correlations dominate west-central IP (Pearson correlation coefficient ρ = + 0.43, for 1001-1990), due to prevalent cold-dry and warm-wet conditions, while this relationship weakens and become negative towards mountainous, northern and eastern regions. In autumn, negative correlations appear in similar regions as in winter, whereas for summer they extend also to the N/NW of the IP. In spring, the whole IP depicts significant negative correlations, strongest for eastern regions (ρ = - 0.51). This is due to prevalent frequency of warm-dry and cold-wet modes in these regions and seasons. At the temporal scale, regional correlation series between seasonal anomalies of temperature and precipitation (assessed in 31 years running windows in 1001-1990) show very large multidecadal variability. For winter and spring, periodicities of about 50-60 years arise. The frequency of warm-dry and cold-wet modes appears correlated with the North Atlantic Oscillation (NAO), explaining mainly co-variability changes in spring. For winter and some regions in autumn, maximum and minimum P-T correlations appear in periods with enhanced meridional or easterly circulation (low or high pressure anomalies in the Mediterranean and Europe). In spring and summer, the Atlantic Multidecadal Oscillation shows some fingerprint on the frequency of warm/cold modes. For future scenarios, an intensification of the negative P-T relationship is generally found, as a result of an increased frequency of the warm-dry mode.

Variation of Geochemical Signatures and Correlation of Biomarkers in Icelandic Mars Analogue Environments

NASA Astrophysics Data System (ADS)

Gentry, D.; Amador, E. S.; Cable, M. L.; Cantrell, T.; Chaudry, N.; Cullen, T.; Duca, Z. A.; Jacobsen, M. B.; McCaig, H. C.; Murukesan, G.; Rennie, V.; Schwieterman, E. W.; Stevens, A. H.; Tan, G.; Yin, C.; Stockton, A.; Cullen, D.; Geppert, W.

2015-12-01

Exploration missions to Mars rely on rovers to perform deep analyses over small sampling areas; however, landing site selection is done using large-scale but low-resolution remote sensing data. Using Earth analogue environments to estimate the small-scale spatial and temporal distributions of key geochemical signatures and (for habitability studies) biomarkers helps ensure that the chosen sampling strategies meet mission science goals. We conducted two rounds of analogue expeditions to recent Icelandic lava fields. In July 2013, we tested correlation between three common biomarker assays: cell quantification via fluorescence microscopy, ATP quantification via bioluminescence, and quantitative PCR with universal primer sets. Sample sites were nested at four spatial scales (1 m, 10 m, 100 m, and > 1 km) and homogeneous at 'remote imaging' resolution (overall temperature, apparent moisture content, and regolith grain size). All spatial scales were highly diverse in ATP, bacterial 16S, and archaeal 16S DNA content; nearly half of sites were statistically different in ATP content at α = 0.05. Cell counts showed significant variation at the 10 m and 100 m scale; at the > 1 km scale, the mean counts were not distinguishable, but the median counts were, indicating differences in underlying distribution. Fungal 18S DNA content similarly varied at 1 m, 10 m, and 100 m scales only. Cell counts were not correlated with ATP or DNA content at any scale. ATP concentration and DNA content for all three primer sets were positively correlated. Bacterial DNA content was positively correlated with archaeal and fungal DNA content, though archaeal correlation was weak. Fungal and archaeal correlation was borderline. In July 2015, we repeated the sampling strategy, with the addition of a smaller-scale sampling grid of 10 cm and a third > 1 km location. This expedition also measured reflectance of the tephra cover and preserved mineral samples for future Raman spectroscopy in order to better distinguish between effects of geochemical variation and intrinsic biomarker variation.

Validation of high-resolution MAIAC aerosol product over South America

NASA Astrophysics Data System (ADS)

Martins, V. S.; Lyapustin, A.; de Carvalho, L. A. S.; Barbosa, C. C. F.; Novo, E. M. L. M.

2017-07-01

Multiangle Implementation of Atmospheric Correction (MAIAC) is a new Moderate Resolution Imaging Spectroradiometer (MODIS) algorithm that combines time series approach and image processing to derive surface reflectance and atmosphere products, such as aerosol optical depth (AOD) and columnar water vapor (CWV). The quality assessment of MAIAC AOD at 1 km resolution is still lacking across South America. In the present study, critical assessment of MAIAC AOD550 was performed using ground-truth data from 19 Aerosol Robotic Network (AERONET) sites over South America. Additionally, we validated the MAIAC CWV retrievals using the same AERONET sites. In general, MAIAC AOD Terra/Aqua retrievals show high agreement with ground-based measurements, with a correlation coefficient (R) close to unity (RTerra:0.956 and RAqua: 0.949). MAIAC accuracy depends on the surface properties and comparisons revealed high confidence retrievals over cropland, forest, savanna, and grassland covers, where more than 2/3 ( 66%) of retrievals are within the expected error (EE = ±(0.05 + 0.05 × AOD)) and R exceeding 0.86. However, AOD retrievals over bright surfaces show lower correlation than those over vegetated areas. Both MAIAC Terra and Aqua retrievals are similarly comparable to AERONET AOD over the MODIS lifetime (small bias offset 0.006). Additionally, MAIAC CWV presents quantitative information with R 0.97 and more than 70% of retrievals within error (±15%). Nonetheless, the time series validation shows an upward bias trend in CWV Terra retrievals and systematic negative bias for CWV Aqua. These results contribute to a comprehensive evaluation of MAIAC AOD retrievals as a new atmospheric product for future aerosol studies over South America.

Bioclimatic Classification of Northeast Asia for climate change response

NASA Astrophysics Data System (ADS)

Choi, Y.; Jeon, S. W.; Lim, C. H.

2016-12-01

As climate change has been getting worse, we should monitor the change of biodiversity, and distribution of species to handle the crisis and take advantage of climate change. The development of bioclimatic map which classifies land into homogenous zones by similar environment properties is the first step to establish a strategy. Statistically derived classifications of land provide useful spatial frameworks to support ecosystem research, monitoring and policy decisions. Many countries are trying to make this kind of map and actively utilize it to ecosystem conservation and management. However, the Northeast Asia including North Korea doesn't have detailed environmental information, and has not built environmental classification map. Therefore, this study presents a bioclimatic map of Northeast Asia based on statistical clustering of bioclimate data. Bioclim data ver1.4 which provided by WorldClim were considered for inclusion in a model. Eight of the most relevant climate variables were selected by correlation analysis, based on previous studies. Principal Components Analysis (PCA) was used to explain 86% of the variation into three independent dimensions, which were subsequently clustered using an ISODATA clustering. The bioclimatic zone of Northeast Asia could consist of 29, 35, and 50 zones. This bioclimatic map has a 30' resolution. To assess the accuracy, the correlation coefficient was calculated between the first principal component values of the classification variables and the vegetation index, Gross Primary Production (GPP). It shows about 0.5 Pearson correlation coefficient. This study constructed Northeast Asia bioclimatic map by statistical method with high resolution, but in order to better reflect the realities, the variety of climate variables should be considered. Also, further studies should do more quantitative and qualitative validation in various ways. Then, this could be used more effectively to support decision making on climate change adaptation.

T2* mapping and delayed gadolinium-enhanced magnetic resonance imaging in cartilage (dGEMRIC) of humeral articular cartilage--a histologically controlled study.

PubMed

Bittersohl, Bernd; Kircher, Jörn; Miese, Falk R; Dekkers, Christin; Habermeyer, Peter; Fröbel, Julia; Antoch, Gerald; Krauspe, Rüdiger; Zilkens, Christoph

2015-10-01

Cartilage biochemical imaging modalities that include the magnetic resonance imaging (MRI) techniques of T2* mapping (sensitive to water content and collagen fiber network) and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC, sensitive to the glycosaminoglycan content) can be effective instruments for early diagnosis and reliable follow-up of cartilage damage. The purpose of this study was to provide T2* mapping and dGEMRIC values in various histologic grades of cartilage degeneration in humeral articular cartilage. A histologically controlled in vitro study was conducted that included human humeral head cartilage specimens with various histologic grades of cartilage degeneration. High-resolution, 3-dimensional (3D) T2* mapping and dGEMRIC were performed that enabled the correlation of MRI and histology data. Cartilage degeneration was graded according to the Mankin score, which evaluates surface morphology, cellularity, toluidine blue staining, and tidemark integrity. SPSS software was used for statistical analyses. Both MRI mapping values decreased significantly (P < .001) with increasing cartilage degeneration. Spearman rank analysis revealed a significant correlation (correlation coefficients ranging from -0.315 to 0.784; P < .001) between the various histologic parameters and the T2* and T1Gd mapping values. This study demonstrates the feasibility of 3D T2* and dGEMRIC to identify various histologic grades of cartilage damage of humeral articular cartilage. With regard to the advantages of these mapping techniques with high image resolution and the ability to accomplish a 3D biochemically sensitive imaging, we consider that these imaging techniques can make a positive contribution to the currently evolving science and practice of cartilage biochemical imaging. Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Identifying Local Hotspots of Pediatric Chronic Diseases Using Emergency Department Surveillance

PubMed Central

Lee, David C.; Yi, Stella S.; Fong, Hiu-Fai; Athens, Jessica K.; Ravenell, Joseph E.; Sevick, Mary Ann; Wall, Stephen P.; Elbel, Brian

2016-01-01

Objective To use novel geographic methods and large-scale claims data to identify the local distribution of pediatric chronic diseases in New York City. Methods Using a 2009 all-payer emergency claims database, we identified the proportion of unique children aged 0 to 17 with diagnosis codes for specific medical and psychiatric conditions. As a proof of concept, we compared these prevalence estimates to traditional health surveys and registry data using the most geographically granular data available. In addition, we used home addresses to map local variation in pediatric disease burden. Results We identified 549,547 New York City children who visited an emergency department at least once in 2009. Though our sample included more publicly insured and uninsured children, we found moderate to strong correlations of prevalence estimates when compared to health surveys and registry data at pre-specified geographic levels. Strongest correlations were found for asthma and mental health conditions by county among younger children (0.88, p=0.05 and 0.99, p<0.01, respectively). Moderate correlations by neighborhood were identified for obesity and cancer (0.53 and 0.54, p<0.01). Among adolescents, correlations by health districts were strong for obesity (0.95, p=0.05), and depression estimates had a non-significant, but strong negative correlation with suicide attempts (−0.88, p=0.12). Using SaTScan, we also identified local hotspots of pediatric chronic disease. Conclusions For conditions easily identified in claims data, emergency department surveillance may help estimate pediatric chronic disease prevalence with higher geographic resolution. More studies are needed to investigate limitations of these methods and assess reliability of local disease estimates. What’s New This study demonstrated how emergency department surveillance may improve estimates of pediatric disease prevalence with higher geographic resolution. We identified 29% of New York City children with a single year of data and identified local hotspots of pediatric chronic diseases. PMID:28385326

A Study of the Extratropical Tropopause from Observations and Models

NASA Astrophysics Data System (ADS)

Wang, Shu Meir

The extratropical tropopause is a familiar feature in meteorology; however, the understanding of the mechanisms for its existence, formation, maintenance and sharpness is still an active area of research. Son and Povalni (2007) used a simple general circulation model to produce the TIL (Tropopause Inversion Layer), and they found that the extratropical tropopause is more sensitive to the change of the horizontal resolution than to the change of the vertical resolution. The extratropical tropopause is sharper and lower in higher horizontal resolution. They also successfully mimicked the seasonal variation of the extratropical tropopause by changing the Equator-to-Pole temperature difference. They found these features of the extratropical tropopause, but they did not explain why these features were seen in their simplified model. In this research, we try to explain why these features of the extratropical tropopause are seen from both observations and the models. I have shown in my MS thesis that the distance from the jet is more associated with the extratropical tropopause than is the upper tropospheric relative vorticity (Wirth, 2001) from observations. In this research, the reproduction of the work is done from both the idealized and the full model run, and the results are similar to those from the observations, which show that even on synoptic time scales, the distance from the jet is more important in determining the extratropical tropopause height than is the upper tropospheric relative vorticity. It also explains the seasonal variations of the extratropical tropopause since the jet is more poleward in summer than in winter (the Equator-to-Pole temperature difference is smaller in summer than in winter), thus there is larger area at south of the jet which means the extratropical tropopause is sharper and higher at midlatitudes in summer than in winter. We believe that baroclinic mixing of PV is the key factor that sharpens the extratropical tropopause, and adequate horizontal resolution is needed to resolve the baroclinic mixing and the small-scale filamentary structures. We used many methods in this study to show that there is more baroclinic activity seen in higher horizontal resolution. We also compared the correlations of the tropopause height with three variations in different quantities (PV fluxes, the upper tropospheric vorticity, and heat fluxes), and found that the correlations of the tropopause height and PV fluxes are the highest among the three. Thus, we conclude that baroclinic mixing is the most important factor that controls the extratropical tropopause sharpness. This also explains why the extratropical tropopause is sharper at midlatitudes when higher horizontal resolution is used (see figure 2.4 in the thesis and figure 2 in Son and Polvani's (2007)) since there is more baroclinic activity in the higher horizontal resolution models. Since there is more baroclinic activity seen in higher horizontal resolution, the baroclinic eddy drag is larger, which intensifies the thermally direct cell. The stronger thermally direct cell with higher horizontal resolution has greater downward motion in higher latitudes, and thus lowers the extratropical tropopause more in higher horizontal resolution models, which explains why the extratropical tropopause is lower in higher horizontal than in lower horizontal resolution models, as in Son and Polvani's (2007) paper.

Definition and estimation of resolution in single-particle reconstructions.

PubMed

Liao, Hstau Y; Frank, Joachim

2010-07-14

In this paper, we review current practices for establishing the resolution in single-particle reconstructions. The classical Raleigh criterion for the resolution is not applicable in this case, and the resolution is commonly defined by a consistency test, whereby the data set is randomly split in half and the two resulting reconstructions are then compared. Such a procedure, however, may introduce statistical dependence between the two half-sets, which leads to a too optimistic resolution estimate. On the other hand, this overestimation is counteracted by the diminished statistical properties of a mere half of the data set. The "true" resolution of the whole data set can be estimated when the functional relationship between the data size and the resolution is known. We are able to estimate this functional by taking into account the B-factor and the geometry of data collection. Finally, the drawbacks of resolution estimation are entirely avoided by computing the correlation of neighboring voxels in the Fourier domain. Copyright 2010 Elsevier Ltd. All rights reserved.

Resolution of ab initio shapes determined from small-angle scattering.

PubMed

Tuukkanen, Anne T; Kleywegt, Gerard J; Svergun, Dmitri I

2016-11-01

Spatial resolution is an important characteristic of structural models, and the authors of structures determined by X-ray crystallography or electron cryo-microscopy always provide the resolution upon publication and deposition. Small-angle scattering of X-rays or neutrons (SAS) has recently become a mainstream structural method providing the overall three-dimensional structures of proteins, nucleic acids and complexes in solution. However, no quantitative resolution measure is available for SAS-derived models, which significantly hampers their validation and further use. Here, a method is derived for resolution assessment for ab initio shape reconstruction from scattering data. The inherent variability of the ab initio shapes is utilized and it is demonstrated how their average Fourier shell correlation function is related to the model resolution. The method is validated against simulated data for proteins with known high-resolution structures and its efficiency is demonstrated in applications to experimental data. It is proposed that henceforth the resolution be reported in publications and depositions of ab initio SAS models.

Resolution of ab initio shapes determined from small-angle scattering

PubMed Central

Tuukkanen, Anne T.; Kleywegt, Gerard J.; Svergun, Dmitri I.

2016-01-01

Spatial resolution is an important characteristic of structural models, and the authors of structures determined by X-ray crystallography or electron cryo-microscopy always provide the resolution upon publication and deposition. Small-angle scattering of X-rays or neutrons (SAS) has recently become a mainstream structural method providing the overall three-dimensional structures of proteins, nucleic acids and complexes in solution. However, no quantitative resolution measure is available for SAS-derived models, which significantly hampers their validation and further use. Here, a method is derived for resolution assessment for ab initio shape reconstruction from scattering data. The inherent variability of the ab initio shapes is utilized and it is demonstrated how their average Fourier shell correlation function is related to the model resolution. The method is validated against simulated data for proteins with known high-resolution structures and its efficiency is demonstrated in applications to experimental data. It is proposed that henceforth the resolution be reported in publications and depositions of ab initio SAS models. PMID:27840683

Tools to Analyze Morphology and Spatially Mapped Molecular Data | Informatics Technology for Cancer Research (ITCR)

Cancer.gov

This project is to develop, deploy, and disseminate a suite of open source tools and integrated informatics platform that will facilitate multi-scale, correlative analyses of high resolution whole slide tissue image data, spatially mapped genetics and molecular data for cancer research. This platform will play an essential role in supporting studies of tumor initiation, development, heterogeneity, invasion, and metastasis.

Demonstration of correlative atomic force and transmission electron microscopy using actin cytoskeleton

PubMed Central

Yamada, Yutaro; Konno, Hiroki; Shimabukuro, Katsuya

2017-01-01

In this study, we present a new technique called correlative atomic force and transmission electron microscopy (correlative AFM/TEM) in which a targeted region of a sample can be observed under AFM and TEM. The ultimate goal of developing this new technique is to provide a technical platform to expand the fields of AFM application to complex biological systems such as cell extracts. Recent advances in the time resolution of AFM have enabled detailed observation of the dynamic nature of biomolecules. However, specifying molecular species, by AFM alone, remains a challenge. Here, we demonstrate correlative AFM/TEM, using actin filaments as a test sample, and further show that immuno-electron microscopy (immuno-EM), to specify molecules, can be integrated into this technique. Therefore, it is now possible to specify molecules, captured under AFM, by subsequent observation using immuno-EM. In conclusion, correlative AFM/TEM can be a versatile method to investigate complex biological systems at the molecular level. PMID:28828286

Millimeter wavelength propagation studies

NASA Technical Reports Server (NTRS)

Hodge, D. B.

1974-01-01

The investigations conducted for the Millimeter Wavelength Propagation Studies during the period December, 1966, to June 1974 are reported. These efforts included the preparation for the ATS-5 Millimeter Wavelength Propagation Experiment and the subsequent data acquisition and data analysis. The emphasis of the OSU participation in this experiment was placed on the determination of reliability improvement resulting from the use of space diversity on a millimeter wavelength earth-space communication link. Related measurements included the determination of the correlation between radiometric temperature and attenuation along the earth-space propagation path. Along with this experimental effort a theoretical model was developed for the prediction of attenuation statistics on single and spatially separated earth space propagation paths. A High Resolution Radar/Radiometer System and Low Resolution Radar System were developed and implemented for the study of intense rain cells in preparation for the ATS-6 Millimeter Wavelength Propagation Experiment.

Constructive conflict and staff consensus in substance abuse treatment.

PubMed

Melnick, Gerald; Wexler, Harry K; Chaple, Michael; Cleland, Charles M

2009-03-01

Previous studies demonstrated the relationship between consensus among both staff and clients with client engagement in treatment and between client consensus and 1-year treatment outcomes. The present article explores the correlates of staff consensus, defined as the level of agreement among staff as to the importance of treatment activities in their program, using a national sample of 80 residential substance abuse treatment programs. Constructive conflict resolution had the largest effect on consensus. Low client-to-staff ratios, staff education, and staff experience in substance abuse treatment were also significantly related to consensus. Frequency of training, an expected correlate of consensus, was negatively associated with consensus, whereas frequency of supervision was not a significant correlate. The implications of the findings for future research and program improvement are discussed.

In situ correlative measurements for the ultraviolet differential absorption lidar and the high spectral resolution lidar air quality remote sensors: 1980 PEPE/NEROS program

NASA Technical Reports Server (NTRS)

Gregory, G. L.; Beck, S. M.; Mathis, J. J., Jr.

1981-01-01

In situ correlative measurements were obtained with a NASA aircraft in support of two NASA airborne remote sensors participating in the Environmental Protection Agency's 1980persistent elevated pollution episode (PEPE) and Northeast regional oxidant study (NEROS) field program in order to provide data for evaluating the capability of two remote sensors for measuring mixing layer height, and ozone and aerosol concentrations in the troposphere during the 1980 PEPE/NEROS program. The in situ aircraft was instrumented to measure temperature, dewpoint temperature, ozone concentrations, and light scattering coefficient. In situ measurements for ten correlative missions are given and discussed. Each data set is presented in graphical and tabular format aircraft flight plans are included.

The investigation of active Martian dune fields using very high resolution photogrammetric measurements

NASA Astrophysics Data System (ADS)

Kim, Jungrack; Kim, Younghwi; Park, Minseong

2016-10-01

At the present time, arguments continue regarding the migration speeds of Martian dune fields and their correlation with atmospheric circulation. However, precisely measuring the spatial translation of Martian dunes has succeeded only a very few times—for example, in the Nili Patera study (Bridges et al. 2012) using change-detection algorithms and orbital imagery. Therefore, in this study, we developed a generic procedure to precisely measure the migration of dune fields with recently introduced 25-cm resolution orbital imagery specifically using a high-accuracy photogrammetric processor. The processor was designed to trace estimated dune migration, albeit slight, over the Martian surface by 1) the introduction of very high resolution ortho images and stereo analysis based on hierarchical geodetic control for better initial point settings; 2) positioning error removal throughout the sensor model refinement with a non-rigorous bundle block adjustment, which makes possible the co-alignment of all images in a time series; and 3) improved sub-pixel co-registration algorithms using optical flow with a refinement stage conducted on a pyramidal grid processor and a blunder classifier. Moreover, volumetric changes of Martian dunes were additionally traced by means of stereo analysis and photoclinometry. The established algorithms have been tested using high-resolution HIRISE time-series images over several Martian dune fields. Dune migrations were iteratively processed both spatially and volumetrically, and the results were integrated to be compared to the Martian climate model. Migrations over well-known crater dune fields appeared to be almost static for the considerable temporal periods and were weakly correlated with wind directions estimated by the Mars Climate Database (Millour et al. 2015). As a result, a number of measurements over dune fields in the Mars Global Dune Database (Hayward et al. 2014) covering polar areas and mid-latitude will be demonstrated. Acknowledgements:The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under iMars grant agreement Nr. 607379.

Improved motion compensation in 3D-CT using respiratory-correlated segment reconstruction: diagnostic and radiotherapy applications.

PubMed

Mori, S; Endo, M; Kohno, R; Minohara, S

2006-09-01

Conventional respiratory-gated CT and four-dimensional CT (4DCT) are disadvantaged by their low temporal resolution, which results in the inclusion of anatomic motion-induced artefacts. These represent a significant source of error both in radiotherapy treatment planning for the thorax and upper abdomen and in diagnostic procedures. In particular, temporal resolution and image quality are vitally important to accurate diagnosis and the minimization of planning target volume margin due to respiratory motion. To improve both temporal resolution and signal-to-noise ratio (SNR), we developed a respiratory-correlated segment reconstruction method (RS) and adapted it to the Feldkamp-Davis-Kress algorithm (FDK) with a 256 multidetector row CT (256MDCT). The 256MDCT scans approximately 100 mm in the craniocaudal direction with a 0.5 mm slice thickness in one rotation. Data acquisition for the RS-FDK relies on the assistance of a respiratory sensing system operating in cine scan mode (continuous axial scan with the table stationary). We evaluated the RS-FDK for volume accuracy and image noise in a phantom study with the 256MDCT and compared results with those for a full scan (FS-FDK), which is usually employed in conventional 4DCT and in half scan (HS-FDK). Results showed that the RS-FDK gave a more accurate volume than the others and had the same SNR as the FS-FDK. In a subsequent animal study, we demonstrated a practical sorting process for projection data which was unaffected by variations in respiratory period, and found that the RS-FDK gave the clearest visualization among the three algorithms of the margins of the liver and pulmonary vessels. In summary, the RS-FDK algorithm provides multi-phase images with higher temporal resolution and better SNR. This method should prove useful when combined with new radiotherapeutic and diagnostic techniques.

High Temporospatial Resolution Dynamic Contrast Enhanced (DCE) Wrist MRI with Variable-Density Pseudo-Random CIRcular Cartesian UnderSampling (CIRCUS) Acquisition: Evaluation of Perfusion in Rheumatoid Arthritis Patients

PubMed Central

Liu, Jing; Pedoia, Valentina; Heilmeier, Ursula; Ku, Eric; Su, Favian; Khanna, Sameer; Imboden, John; Graf, Jonathan; Link, Thomas; Li, Xiaojuan

2016-01-01

This study is to evaluate highly accelerated 3D dynamic contrast-enhanced (DCE) wrist MRI for assessment of perfusion in rheumatoid arthritis (RA) patients. A pseudo-random variable-density undersampling strategy, CIRcular Cartesian UnderSampling (CIRCUS), was combined with k-t SPARSE-SENSE reconstruction to achieve a highly accelerated 3D DCE wrist MRI. Two healthy volunteers and ten RA patients were studied. Two patients were on methotrexate (MTX) only (Group I) and the other eight were treated with a combination therapy of MTX and Anti-Tumour Necrosis Factor (TNF) therapy (Group II). Patients were scanned at baseline and 3-month follow-up. DCE MR images were used to evaluate perfusion in synovitis and bone marrow edema pattern in the RA wrist joints. A series of perfusion parameters were derived and compared with clinical disease activity scores of 28 joints (DAS28). 3D DCE wrist MR images were obtained with a spatial resolution of 0.3×0.3×1.5mm3 and temporal resolution of 5 s (with an acceleration factor of 20). The derived perfusion parameters, most notably, transition time (dT) of synovitis, showed significant negative correlations with DAS28-ESR (r=-0.80, p<0.05) and DAS28-CRP (r=-0.87, p<0.05) at baseline and also correlated significantly with treatment responses evaluated by clinical score changes between baseline and 3-month follow-up (with DAS28-ESR: r=-0.79, p<0.05, and DAS28-CRP: r=-0.82, p<0.05). Highly accelerated 3D DCE wrist MRI with improved temporospatial resolution has been achieved in RA patients and provides accurate assessment of neovascularization and perfusion in RA joints, showing promise as a potential tool for evaluating treatment responses. PMID:26608949

High-Resolution 7T MR Imaging of the Motor Cortex in Amyotrophic Lateral Sclerosis.

PubMed

Cosottini, M; Donatelli, G; Costagli, M; Caldarazzo Ienco, E; Frosini, D; Pesaresi, I; Biagi, L; Siciliano, G; Tosetti, M

2016-03-01

Amyotrophic lateral sclerosis is a progressive motor neuron disorder that involves degeneration of both upper and lower motor neurons. In patients with amyotrophic lateral sclerosis, pathologic studies and ex vivo high-resolution MR imaging at ultra-high field strength revealed the co-localization of iron and activated microglia distributed in the deep layers of the primary motor cortex. The aims of the study were to measure the cortical thickness and evaluate the distribution of iron-related signal changes in the primary motor cortex of patients with amyotrophic lateral sclerosis as possible in vivo biomarkers of upper motor neuron impairment. Twenty-two patients with definite amyotrophic lateral sclerosis and 14 healthy subjects underwent a high-resolution 2D multiecho gradient-recalled sequence targeted on the primary motor cortex by using a 7T scanner. Image analysis consisted of the visual evaluation and quantitative measurement of signal intensity and cortical thickness of the primary motor cortex in patients and controls. Qualitative and quantitative MR imaging parameters were correlated with electrophysiologic and laboratory data and with clinical scores. Ultra-high field MR imaging revealed atrophy and signal hypointensity in the deep layers of the primary motor cortex of patients with amyotrophic lateral sclerosis with a diagnostic accuracy of 71%. Signal hypointensity of the deep layers of the primary motor cortex correlated with upper motor neuron impairment (r = -0.47; P < .001) and with disease progression rate (r = -0.60; P = .009). The combined high spatial resolution and sensitivity to paramagnetic substances of 7T MR imaging demonstrate in vivo signal changes of the cerebral motor cortex that resemble the distribution of activated microglia within the cortex of patients with amyotrophic lateral sclerosis. Cortical thinning and signal hypointensity of the deep layers of the primary motor cortex could constitute a marker of upper motor neuron impairment in patients with amyotrophic lateral sclerosis. © 2016 by American Journal of Neuroradiology.

Computational analysis of high resolution unsteady airloads for rotor aeroacoustics

NASA Technical Reports Server (NTRS)

Quackenbush, Todd R.; Lam, C.-M. Gordon; Wachspress, Daniel A.; Bliss, Donald B.

1994-01-01

The study of helicopter aerodynamic loading for acoustics applications requires the application of efficient yet accurate simulations of the velocity field induced by the rotor's vortex wake. This report summarizes work to date on the development of such an analysis, which builds on the Constant Vorticity Contour (CVC) free wake model, previously implemented for the study of vibratory loading in the RotorCRAFT computer code. The present effort has focused on implementation of an airload reconstruction approach that computes high resolution airload solutions of rotor/rotor-wake interactions required for acoustics computations. Supplementary efforts on the development of improved vortex core modeling, unsteady aerodynamic effects, higher spatial resolution of rotor loading, and fast vortex wake implementations have substantially enhanced the capabilities of the resulting software, denoted RotorCRAFT/AA (AeroAcoustics). Results of validation calculations using recently acquired model rotor data show that by employing airload reconstruction it is possible to apply the CVC wake analysis with temporal and spatial resolution suitable for acoustics applications while reducing the computation time required by one to two orders of magnitude relative to that required by direct calculations. Promising correlation with this body of airload and noise data has been obtained for a variety of rotor configurations and operating conditions.

Human movement stochastic variability leads to diagnostic biomarkers In Autism Spectrum Disorders (ASD)

NASA Astrophysics Data System (ADS)

Wu, Di; Torres, Elizabeth B.; Jose, Jorge V.

2015-03-01

ASD is a spectrum of neurodevelopmental disorders. The high heterogeneity of the symptoms associated with the disorder impedes efficient diagnoses based on human observations. Recent advances with high-resolution MEM wearable sensors enable accurate movement measurements that may escape the naked eye. It calls for objective metrics to extract physiological relevant information from the rapidly accumulating data. In this talk we'll discuss the statistical analysis of movement data continuously collected with high-resolution sensors at 240Hz. We calculated statistical properties of speed fluctuations within the millisecond time range that closely correlate with the subjects' cognitive abilities. We computed the periodicity and synchronicity of the speed fluctuations' from their power spectrum and ensemble averaged two-point cross-correlation function. We built a two-parameter phase space from the temporal statistical analyses of the nearest neighbor fluctuations that provided a quantitative biomarker for ASD and adult normal subjects and further classified ASD severity. We also found age related developmental statistical signatures and potential ASD parental links in our movement dynamical studies. Our results may have direct clinical applications.

Probing condensed matter physics with magnetometry based on nitrogen-vacancy centres in diamond

NASA Astrophysics Data System (ADS)

Casola, Francesco; van der Sar, Toeno; Yacoby, Amir

2018-01-01

The magnetic fields generated by spins and currents provide a unique window into the physics of correlated-electron materials and devices. First proposed only a decade ago, magnetometry based on the electron spin of nitrogen-vacancy (NV) defects in diamond is emerging as a platform that is excellently suited for probing condensed matter systems; it can be operated from cryogenic temperatures to above room temperature, has a dynamic range spanning from direct current to gigahertz and allows sensor-sample distances as small as a few nanometres. As such, NV magnetometry provides access to static and dynamic magnetic and electronic phenomena with nanoscale spatial resolution. Pioneering work has focused on proof-of-principle demonstrations of its nanoscale imaging resolution and magnetic field sensitivity. Now, experiments are starting to probe the correlated-electron physics of magnets and superconductors and to explore the current distributions in low-dimensional materials. In this Review, we discuss the application of NV magnetometry to the exploration of condensed matter physics, focusing on its use to study static and dynamic magnetic textures and static and dynamic current distributions.

Longterm monitoring of pressure, tilt and temperature at Logatchev Hydrothermal Vent Field, Mid-Atlantic Ridge

NASA Astrophysics Data System (ADS)

Villinger, H. W.; Gennerich, H.-H.; Fabian, M.

2009-04-01

The geophysical parameters of pressure, tilt, acceleration and temperature at the Logatchev Hydrothermal Vent Field (LHF) which is located in 3050m water depth at about 15˚ N at the Mid-Atlantic Ridge, were monitored with high resolution for more than two and a half years, from May 2005 until December 2007. An autonomously operating Ocean Bottom Pressure Station (OBP; resolution of 80 Pa in the first year, improved to 8 Pa afterwards, sampling period of 2 minutes in the first year, increased to 2 seconds afterwards) and a programmable Ocean Bottom Tiltmeter (OBT; resolution 1 rad, sampling period 6 seconds) measured local ocean-floor point motions derived from tilt and absolute pressure. In addition, vertical acceleration was measured using a MEMS accelerometer (resolution 10-5 m/s2, sampling rate 1.33 Hz) within the housing of the OBT. Numerous autonomous temperature loggers (resolution 0.001˚ C, sampling period 15 minutes) were installed at prominent places like mussel fields or soil fissures within the LHF. Time series are analyzed using Fourier-Transformation techniques but also using the novel approach called Empirical Mode Decomposition (EMD). Pressure records show a modulated background noise level with increased amplitudes lasting for several days to weeks, and most likely show signals generated by local earthquakes. Bottom water temperature has transients with peak-to-peak-amplitudes of up to 0.1˚ C, which correlate for a number of events directly with earthquake signals. A comparison of pressure, tilt, acceleration and temperature data events shows that all four records are correlated. For a few of those events a direct causal link can be firmly established. The study is funded by the Deutsche Forschungsgemeinschaft (DFG) and part of Priority Program 1144 ("From Mantle to Ocean: Energy-, Material- and Life-cycles at Spreading Axes").

Practical aspects of estimating energy components in rodents

PubMed Central

van Klinken, Jan B.; van den Berg, Sjoerd A. A.; van Dijk, Ko Willems

2013-01-01

Recently there has been an increasing interest in exploiting computational and statistical techniques for the purpose of component analysis of indirect calorimetry data. Using these methods it becomes possible to dissect daily energy expenditure into its components and to assess the dynamic response of the resting metabolic rate (RMR) to nutritional and pharmacological manipulations. To perform robust component analysis, however, is not straightforward and typically requires the tuning of parameters and the preprocessing of data. Moreover the degree of accuracy that can be attained by these methods depends on the configuration of the system, which must be properly taken into account when setting up experimental studies. Here, we review the methods of Kalman filtering, linear, and penalized spline regression, and minimal energy expenditure estimation in the context of component analysis and discuss their results on high resolution datasets from mice and rats. In addition, we investigate the effect of the sample time, the accuracy of the activity sensor, and the washout time of the chamber on the estimation accuracy. We found that on the high resolution data there was a strong correlation between the results of Kalman filtering and penalized spline (P-spline) regression, except for the activity respiratory quotient (RQ). For low resolution data the basal metabolic rate (BMR) and resting RQ could still be estimated accurately with P-spline regression, having a strong correlation with the high resolution estimate (R2 > 0.997; sample time of 9 min). In contrast, the thermic effect of food (TEF) and activity related energy expenditure (AEE) were more sensitive to a reduction in the sample rate (R2 > 0.97). In conclusion, for component analysis on data generated by single channel systems with continuous data acquisition both Kalman filtering and P-spline regression can be used, while for low resolution data from multichannel systems P-spline regression gives more robust results. PMID:23641217

Ecogenomic sensor reveals controls on N2-fixing microorganisms in the North Pacific Ocean.

PubMed

Robidart, Julie C; Church, Matthew J; Ryan, John P; Ascani, François; Wilson, Samuel T; Bombar, Deniz; Marin, Roman; Richards, Kelvin J; Karl, David M; Scholin, Christopher A; Zehr, Jonathan P

2014-06-01

Nitrogen-fixing microorganisms (diazotrophs) are keystone species that reduce atmospheric dinitrogen (N2) gas to fixed nitrogen (N), thereby accounting for much of N-based new production annually in the oligotrophic North Pacific. However, current approaches to study N2 fixation provide relatively limited spatiotemporal sampling resolution; hence, little is known about the ecological controls on these microorganisms or the scales over which they change. In the present study, we used a drifting robotic gene sensor to obtain high-resolution data on the distributions and abundances of N2-fixing populations over small spatiotemporal scales. The resulting measurements demonstrate that concentrations of N2 fixers can be highly variable, changing in abundance by nearly three orders of magnitude in less than 2 days and 30 km. Concurrent shipboard measurements and long-term time-series sampling uncovered a striking and previously unrecognized correlation between phosphate, which is undergoing long-term change in the region, and N2-fixing cyanobacterial abundances. These results underscore the value of high-resolution sampling and its applications for modeling the effects of global change.

Investigation of spatial resolution dependent variability in transcutaneous oxygen saturation using point spectroscopy system

NASA Astrophysics Data System (ADS)

Philimon, Sheena P.; Huong, Audrey K. C.; Ngu, Xavier T. I.

2017-08-01

This paper aims to investigate the variation in one’s percent mean transcutaneous oxygen saturation (StO2) with differences in spatial resolution of data. This work required the knowledge of extinction coefficient of hemoglobin derivatives in the wavelength range of 520 - 600 nm to solve for the StO2 value via an iterative fitting procedure. A pilot study was conducted on three healthy subjects with spectroscopic data collected from their right index finger at different arbitrarily selected distances. The StO2 value estimated by Extended Modified Lambert Beer (EMLB) model revealed a higher mean StO2 of 91.1 ± 1.3% at a proximity distance of 30 mm compared to 60.83 ± 2.8% at 200 mm. The results showed a high correlation between data spatial resolution and StO2 value, and revealed a decrease in StO2 value as the sampling distance increased. The preliminary findings from this study contribute to the knowledge of the appropriate distance range for consistent and high repeatability measurement of skin oxygenation.

Submillisecond X-ray photon correlation spectroscopy from a pixel array detector with fast dual gating and no readout dead-time

DOE PAGES

Zhang, Qingteng; Dufresne, Eric M.; Grybos, Pawel; ...

2016-04-19

Small-angle scattering X-ray photon correlation spectroscopy (XPCS) studies were performed using a novel photon-counting pixel array detector with dual counters for each pixel. Each counter can be read out independently from the other to ensure there is no readout dead-time between the neighboring frames. A maximum frame rate of 11.8 kHz was achieved. Results on test samples show good agreement with simple diffusion. Lastly, the potential of extending the time resolution of XPCS beyond the limit set by the detector frame rate using dual counters is also discussed.

Submillisecond X-ray photon correlation spectroscopy from a pixel array detector with fast dual gating and no readout dead-time

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Qingteng; Dufresne, Eric M.; Grybos, Pawel

Small-angle scattering X-ray photon correlation spectroscopy (XPCS) studies were performed using a novel photon-counting pixel array detector with dual counters for each pixel. Each counter can be read out independently from the other to ensure there is no readout dead-time between the neighboring frames. A maximum frame rate of 11.8 kHz was achieved. Results on test samples show good agreement with simple diffusion. Lastly, the potential of extending the time resolution of XPCS beyond the limit set by the detector frame rate using dual counters is also discussed.

Submillisecond X-ray photon correlation spectroscopy from a pixel array detector with fast dual gating and no readout dead-time.

PubMed

Zhang, Qingteng; Dufresne, Eric M; Grybos, Pawel; Kmon, Piotr; Maj, Piotr; Narayanan, Suresh; Deptuch, Grzegorz W; Szczygiel, Robert; Sandy, Alec

2016-05-01

Small-angle scattering X-ray photon correlation spectroscopy (XPCS) studies were performed using a novel photon-counting pixel array detector with dual counters for each pixel. Each counter can be read out independently from the other to ensure there is no readout dead-time between the neighboring frames. A maximum frame rate of 11.8 kHz was achieved. Results on test samples show good agreement with simple diffusion. The potential of extending the time resolution of XPCS beyond the limit set by the detector frame rate using dual counters is also discussed.

Brief communication: Landslide motion from cross correlation of UAV-derived morphological attributes

NASA Astrophysics Data System (ADS)

Peppa, Maria V.; Mills, Jon P.; Moore, Phil; Miller, Pauline E.; Chambers, Jonathan E.

2017-12-01

Unmanned aerial vehicles (UAVs) can provide observations of high spatio-temporal resolution to enable operational landslide monitoring. In this research, the construction of digital elevation models (DEMs) and orthomosaics from UAV imagery is achieved using structure-from-motion (SfM) photogrammetric procedures. The study examines the additional value that the morphological attribute of openness, amongst others, can provide to surface deformation analysis. Image-cross-correlation functions and DEM subtraction techniques are applied to the SfM outputs. Through the proposed integrated analysis, the automated quantification of a landslide's motion over time is demonstrated, with implications for the wider interpretation of landslide kinematics via UAV surveys.

Wait, are you sad or angry? Large exposure time differences required for the categorization of facial expressions of emotion

PubMed Central

Du, Shichuan; Martinez, Aleix M.

2013-01-01

Abstract Facial expressions of emotion are essential components of human behavior, yet little is known about the hierarchical organization of their cognitive analysis. We study the minimum exposure time needed to successfully classify the six classical facial expressions of emotion (joy, surprise, sadness, anger, disgust, fear) plus neutral as seen at different image resolutions (240 × 160 to 15 × 10 pixels). Our results suggest a consistent hierarchical analysis of these facial expressions regardless of the resolution of the stimuli. Happiness and surprise can be recognized after very short exposure times (10–20 ms), even at low resolutions. Fear and anger are recognized the slowest (100–250 ms), even in high-resolution images, suggesting a later computation. Sadness and disgust are recognized in between (70–200 ms). The minimum exposure time required for successful classification of each facial expression correlates with the ability of a human subject to identify it correctly at low resolutions. These results suggest a fast, early computation of expressions represented mostly by low spatial frequencies or global configural cues and a later, slower process for those categories requiring a more fine-grained analysis of the image. We also demonstrate that those expressions that are mostly visible in higher-resolution images are not recognized as accurately. We summarize implications for current computational models. PMID:23509409

Improving Numerical Weather Predictions of Summertime Precipitation Over the Southeastern U.S. Through a High-Resolution Initialization of the Surface State

NASA Technical Reports Server (NTRS)

Case, Jonathan L.; Kumar, Sujay V.; Krikishen, Jayanthi; Jedlovec, Gary J.

2011-01-01

It is hypothesized that high-resolution, accurate representations of surface properties such as soil moisture and sea surface temperature are necessary to improve simulations of summertime pulse-type convective precipitation in high resolution models. This paper presents model verification results of a case study period from June-August 2008 over the Southeastern U.S. using the Weather Research and Forecasting numerical weather prediction model. Experimental simulations initialized with high-resolution land surface fields from the NASA Land Information System (LIS) and sea surface temperature (SST) derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) are compared to a set of control simulations initialized with interpolated fields from the National Centers for Environmental Prediction 12-km North American Mesoscale model. The LIS land surface and MODIS SSTs provide a more detailed surface initialization at a resolution comparable to the 4-km model grid spacing. Soil moisture from the LIS spin-up run is shown to respond better to the extreme rainfall of Tropical Storm Fay in August 2008 over the Florida peninsula. The LIS has slightly lower errors and higher anomaly correlations in the top soil layer, but exhibits a stronger dry bias in the root zone. The model sensitivity to the alternative surface initial conditions is examined for a sample case, showing that the LIS/MODIS data substantially impact surface and boundary layer properties.

Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution.

PubMed

Kellermair, Joerg; Redwan, Bassam; Alias, Sherin; Jabkowski, Joerg; Panzenboeck, Adelheid; Kellermair, Lukas; Winter, Max P; Weltermann, Ansgar; Lang, Irene M

2013-11-07

Platelet endothelial cell adhesion molecule 1 (PECAM-1) is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution. This study investigated the effect of PECAM-1 deficiency on thrombus resolution in FVB/n mice and the extent to which levels of soluble PECAM-1 (sPECAM-1) correlate with delayed thrombus resolution in humans after acute symptomatic deep vein thrombosis (DVT). In a mouse stagnant flow venous thrombosis model Pecam-1(-/-) thrombi were larger, persisted for longer periods of time, and displayed attenuated macrophage invasion and decreased vessel formation in the presence of increased fibrosis. In humans, higher levels of truncated plasma sPECAM-1 possibly cleaved from cell surfaces, were found in patients with delayed thrombus resolution (assessed via duplex-based thrombus scoring) relative to those whose thrombi resolved (median, 25th/75th percentile): 92.5 (87.7/103.4) ng/mL vs 71.5 (51.1/81.0) ng/mL; P < .001. Furthermore, unresolved human deep vein thrombus specimens stained positively with antibodies specific for the extracellular, but not the cytoplasmic domain of PECAM-1, consistent with accumulation of cleaved PECAM-1. Our data suggest a regulatory role of PECAM-1 in venous thrombus resolution and suggest a predictive value of sPECAM-1 for postthrombotic syndrome (PTS) after acute DVT.

Observed circuit limits to time resolution in correlation measurements with Si-on-sapphire, GaAs, and InP picosecond photoconductors

NASA Astrophysics Data System (ADS)

Hammond, R. B.; Paulter, N. G.; Wagner, R. S.

1984-08-01

Cross-correlation measurements of the response of photoconductor pulsers and sampling gates excited by a femtosecond laser are reported. The photoconductors were fabricated in microstrip transmission line structures on Si-on-sapphire, semiinsulating GaAs, and semiinsulating InP wafers. The photoconductor sampling gates were ion beam-damaged to produce short carrier lifetimes (less than 3 ps in one case). Damage was introduced with 6 MeV Ne-20 on the Si-on-sapphire, 2 MeV H-2 on the GaAs, and 2 MeV He-4 on the InP. Doses in the range 10 to the 12th - 10 to the 15th were used. Results show circuit limits to the time resolution in correlation measurements from two sources: (1) RC time constants due to photoconductor gap capacitance and transmission line characteristic impedance and (2) dispersion in microstrip transmission lines.

Assessing the resolution-dependent utility of tomograms for geostatistics

USGS Publications Warehouse

Day-Lewis, F. D.; Lane, J.W.

2004-01-01

Geophysical tomograms are used increasingly as auxiliary data for geostatistical modeling of aquifer and reservoir properties. The correlation between tomographic estimates and hydrogeologic properties is commonly based on laboratory measurements, co-located measurements at boreholes, or petrophysical models. The inferred correlation is assumed uniform throughout the interwell region; however, tomographic resolution varies spatially due to acquisition geometry, regularization, data error, and the physics underlying the geophysical measurements. Blurring and inversion artifacts are expected in regions traversed by few or only low-angle raypaths. In the context of radar traveltime tomography, we derive analytical models for (1) the variance of tomographic estimates, (2) the spatially variable correlation with a hydrologic parameter of interest, and (3) the spatial covariance of tomographic estimates. Synthetic examples demonstrate that tomograms of qualitative value may have limited utility for geostatistics; moreover, the imprint of regularization may preclude inference of meaningful spatial statistics from tomograms.

Strong correlation between early stage atherosclerosis and electromechanical coupling of aorta

NASA Astrophysics Data System (ADS)

Liu, X. Y.; Yan, F.; Niu, L. L.; Chen, Q. N.; Zheng, H. R.; Li, J. Y.

2016-03-01

Atherosclerosis is the underlying cause of cardiovascular diseases that are responsible for many deaths in the world, and the early diagnosis of atherosclerosis is highly desirable. The existing imaging methods, however, are not capable of detecting the early stage of atherosclerosis development due to their limited spatial resolution. Using piezoresponse force microscopy (PFM), we show that the piezoelectric response of an aortic wall increases as atherosclerosis advances, while the stiffness of the aorta shows a less evident correlation with atherosclerosis. Furthermore, we show that there is strong correlation between the coercive electric field necessary to switch the polarity of the artery and the development of atherosclerosis. Thus by measuring the electromechanical coupling of the aortic wall, it is possible to probe atherosclerosis at the early stage of its development, not only improving the spatial resolution by orders of magnitude, but also providing comprehensive quantitative information on the biomechanical properties of the artery.

Observation of non-classical correlations in sequential measurements of photon polarization

NASA Astrophysics Data System (ADS)

Suzuki, Yutaro; Iinuma, Masataka; Hofmann, Holger F.

2016-10-01

A sequential measurement of two non-commuting quantum observables results in a joint probability distribution for all output combinations that can be explained in terms of an initial joint quasi-probability of the non-commuting observables, modified by the resolution errors and back-action of the initial measurement. Here, we show that the error statistics of a sequential measurement of photon polarization performed at different measurement strengths can be described consistently by an imaginary correlation between the statistics of resolution and back-action. The experimental setup was designed to realize variable strength measurements with well-controlled imaginary correlation between the statistical errors caused by the initial measurement of diagonal polarizations, followed by a precise measurement of the horizontal/vertical polarization. We perform the experimental characterization of an elliptically polarized input state and show that the same complex joint probability distribution is obtained at any measurement strength.

Correlating Mediterranean shallow water deposits with global Oligocene–Miocene stratigraphy and oceanic events☆

PubMed Central

Reuter, Markus; Piller, Werner E.; Brandano, Marco; Harzhauser, Mathias

2013-01-01

Shallow-marine sediment records have the strong potential to display sensitive environmental changes in sedimentary geometries and skeletal content. However, the time resolution of most neritic carbonate records is not high enough to be compared with climatic events as recorded in the deep-sea sediment archives. In order to resolve the paleoceanographic and paleoclimatic changes during the Oligocene–Miocene transition in the Mediterranean shallow water carbonate systems with the best possible time resolution, we re-evaluated the Decontra section on the Maiella Platform (central Apennines, Italy), which acts as a reference for the correlation of Oligocene–Miocene shallow water deposits in the Mediterranean region. The 120-m-thick late Oligocene–late Miocene carbonate succession is composed of larger foraminiferal, bryozoan and corallinacean limestones interlayered with distinct planktonic foraminiferal carbonates representing a mostly outer neritic setting. Integrated multi-proxy and facies analyses indicate that CaCO3 and total organic carbon contents as well as gamma-ray display only local to regional processes on the carbonate platform and are not suited for stratigraphic correlation on a wider scale. In contrast, new biostratigraphic data correlate the Decontra stable carbon isotope record to the global deep-sea carbon isotope record. This links relative sea level fluctuations, which are reflected by facies and magnetic susceptibility changes, to third-order eustatic cycles. The new integrated bio-, chemo-, and sequence stratigraphic framework enables a more precise timing of environmental changes within the studied time interval and identifies Decontra as an important locality for correlating not only shallow and deep water sediments of the Mediterranean region but also on a global scale. PMID:25844021

Multi-scale variability and long-range memory in indoor Radon concentrations from Coimbra, Portugal

NASA Astrophysics Data System (ADS)

Donner, Reik V.; Potirakis, Stelios; Barbosa, Susana

2014-05-01

The presence or absence of long-range correlations in the variations of indoor Radon concentrations has recently attracted considerable interest. As a radioactive gas naturally emitted from the ground in certain geological settings, understanding environmental factors controlling Radon concentrations and their dynamics is important for estimating its effect on human health and the efficiency of possible measures for reducing the corresponding exposition. In this work, we re-analyze two high-resolution records of indoor Radon concentrations from Coimbra, Portugal, each of which spans several months of continuous measurements. In order to evaluate the presence of long-range correlations and fractal scaling, we utilize a multiplicity of complementary methods, including power spectral analysis, ARFIMA modeling, classical and multi-fractal detrended fluctuation analysis, and two different estimators of the signals' fractal dimensions. Power spectra and fluctuation functions reveal some complex behavior with qualitatively different properties on different time-scales: white noise in the high-frequency part, indications of some long-range correlated process dominating time scales of several hours to days, and pronounced low-frequency variability associated with tidal and/or meteorological forcing. In order to further decompose these different scales of variability, we apply two different approaches. On the one hand, applying multi-resolution analysis based on the discrete wavelet transform allows separately studying contributions on different time scales and characterize their specific correlation and scaling properties. On the other hand, singular system analysis (SSA) provides a reconstruction of the essential modes of variability. Specifically, by considering only the first leading SSA modes, we achieve an efficient de-noising of our environmental signals, highlighting the low-frequency variations together with some distinct scaling on sub-daily time-scales resembling the properties of a long-range correlated process.

Ternary isocratic mobile phase optimization utilizing resolution Design Space based on retention time and peak width modeling.

PubMed

Kawabe, Takefumi; Tomitsuka, Toshiaki; Kajiro, Toshi; Kishi, Naoyuki; Toyo'oka, Toshimasa

2013-01-18

An optimization procedure of ternary isocratic mobile phase composition in the HPLC method using a statistical prediction model and visualization technique is described. In this report, two prediction models were first evaluated to obtain reliable prediction results. The retention time prediction model was constructed by modification from past respectable knowledge of retention modeling against ternary solvent strength changes. An excellent correlation between observed and predicted retention time was given in various kinds of pharmaceutical compounds by the multiple regression modeling of solvent strength parameters. The peak width of half height prediction model employed polynomial fitting of the retention time, because a linear relationship between the peak width of half height and the retention time was not obtained even after taking into account the contribution of the extra-column effect based on a moment method. Accurate prediction results were able to be obtained by such model, showing mostly over 0.99 value of correlation coefficient between observed and predicted peak width of half height. Then, a procedure to visualize a resolution Design Space was tried as the secondary challenge. An artificial neural network method was performed to link directly between ternary solvent strength parameters and predicted resolution, which were determined by accurate prediction results of retention time and a peak width of half height, and to visualize appropriate ternary mobile phase compositions as a range of resolution over 1.5 on the contour profile. By using mixtures of similar pharmaceutical compounds in case studies, we verified a possibility of prediction to find the optimal range of condition. Observed chromatographic results on the optimal condition mostly matched with the prediction and the average of difference between observed and predicted resolution were approximately 0.3. This means that enough accuracy for prediction could be achieved by the proposed procedure. Consequently, the procedure to search the optimal range of ternary solvent strength achieving an appropriate separation is provided by using the resolution Design Space based on accurate prediction. Copyright © 2012 Elsevier B.V. All rights reserved.

Importing super-resolution imaging into nanoscale puzzles of materials dynamics

NASA Astrophysics Data System (ADS)

King, John; Tsang, Chi Hang Boyce; Wilson, William; Granick, Steve

2014-03-01

A limitation of the exciting recent advances in sub-diffraction microscopy is that they focus on imaging rather than dynamical changes. We are engaged in extending this technique beyond the usual biological applications to address materials problems instead. To this end, we employ stimulated emission depletion (STED) microscopy, which relies on selectively turning off fluorescence emitters through stimulated emission, allowing only a small subset of emitters to be detected, such that the excitation spot size can be downsized to tens of nanometers. By coupling the STED excitation scheme to fluorescence correlation spectroscopy (FCS), diffusive processes are studied with nanoscale resolution. Here, we demonstrate the benefits of such experimental capabilities in a diverse range of complex systems, ranging from the diffusion of nano-objects in crowded 3D environments to the study of polymer diffusion on 2D surfaces.

The Chronic Obstructive Sialadenitis Symptoms Questionnaire to assess sialendoscopy-assisted surgery.

PubMed

Aubin-Pouliot, Annick; Delagnes, Elise A; Eisele, David W; Chang, Jolie L; Ryan, William R

2016-01-01

Introduce the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire to quantify chronic sialadenitis symptoms and assess the impact of sialendoscopic-assisted salivary duct surgery (SASDS). Retrospective outcome symptoms questionnaire study. The COSS questionnaire assesses the severity of sialadenitis symptoms from 0 to 100. Patients who underwent SASDS from April 2006 to December 2013 completed the COSS questionnaire and the ShortForm8 Health Survey (SF-8) based on current symptoms, and reported whether they had complete, partial, or no symptomatic response to SASDS. Sixty-six of the 156 (43%) contacted patients completed the questionnaires who had had symptoms in 26 submandibular ducts and 53 parotid ducts. The mean COSS score was higher for parotid ducts (12.0; interquartile range [IQR] 1.0-20.0) than for submandibular ducts (7.6; IQR 0.5-15.0) but not significantly so (P = 0.20). Thirty-eight (60%) patients reported complete resolution of symptoms, with a mean COSS score of 4.5 (IQR 0-7). Twenty-one (33%) patients reported partial resolution, with a mean COSS score of 18.5 (IQR 11.3-22.8). Five (8%) patients reported no improvement, with a mean COSS score of 25.1 (IQR 15.2-35). Thirty-six (46%) ducts with sialoliths had a significantly lower mean COSS score (5.8; IQR 0-9.5) compared to those without sialoliths (14.2; IQR 4.5-21.5, P = 0.0004). There was no significant difference in SF-8 survey scores between these groups. The COSS questionnaire is a novel survey instrument to measure obstructive sialadenitis symptom severity that could be helpful in defining outcomes of SASDS. COSS scores under 10 correlate with complete resolution of symptoms, whereas scores between 10 and 25 correlate with partial resolution. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

The spatial variation of the infrared-to-radio ratio in spiral galaxies

NASA Technical Reports Server (NTRS)

Marsh, K. A.; Helou, G.

1995-01-01

We have produced two-dimensional maps of the intensity ratio, Q(sub 60), of 60 micron infrared to 20 cm radio continuum emission, for a set of 25 nearby galaxies, mostly spirals. The ratio maps were obtained from infrared images made using IRAS data with the maximum correlation method, and radio images made using VLA data. Before taking the ratio, the radio images were processed so as to have the same resolution properties as the infrared images; the final spatial resolution in all cases is approximately 1 min, corresponding to 1 - 2 kpc for most galaxies. This resolution represents a significant improvement over previous studies. Our new high-resolution maps confirm the slow decrease of Q(sub 60) with increasing radial distance from the nucleus, but show additional structure which is probably associated with separate sites of active star formation in the spiral arms. The maps show Q(sub 60) to be more closely related to infrared surface brightness than to the radial distance r in the galaxy disk. We note also that the Q(sub 60) gradients are absent (or at least reduced) for the edge-on galaxies, a property which can be attributed to the dilution of contrast due to the averaging of the additional structure along the line of sight. The results are all in qualitative agreement with the suggestion that the radio image represents a smeared version of the infrared image, as would be expected on the basis of current models in which the infrared-radio correlation is driven by the formation of massive stars, and the intensity distribution of radio emission is smeared as a result of the propagation of energetic electrons accelerated during the supernova phase.

Quantification of experimental venous thrombus resolution by longitudinal nanogold-enhanced micro-computed tomography.

PubMed

Grover, Steven P; Saha, Prakash; Jenkins, Julia; Mukkavilli, Arun; Lyons, Oliver T; Patel, Ashish S; Sunassee, Kavitha; Modarai, Bijan; Smith, Alberto

2015-12-01

The assessment of thrombus size following treatments directed at preventing thrombosis or enhancing its resolution has generally relied on physical or histological methods. This cross-sectional design imposes the need for increased numbers of animals for experiments. Micro-computed tomography (microCT) has been used to detect the presence of venous thrombus in experimental models but has yet to be used in a quantitative manner. In this study, we investigate the use of contrast-enhanced microCT for the longitudinal assessment of experimental venous thrombus resolution. Thrombi induced by stenosis of the inferior vena cava in mice were imaged by contrast-enhanced microCT at 1, 7 and 14 days post-induction (n=18). Thrombus volumes were determined longitudinally by segmentation and 3D volume reconstruction of microCT scans and by standard end-point histological analysis at day 14. An additional group of thrombi were analysed solely by histology at 1, 7 and 14 days post-induction (n=15). IVC resident thrombus was readily detectable by contrast-enhanced microCT. MicroCT-derived measurements of thrombus volume correlated well with time-matched histological analyses (ICC=0.75, P<0.01). Thrombus volumes measured by microCT were significantly greater than those derived from histological analysis (P<0.001). Intra- and inter-observer analyses were highly correlated (ICC=0.99 and 0.91 respectively, P<0.0001). Further histological analysis revealed noticeable levels of contrast agent extravasation into the thrombus that was associated with the presence of neovascular channels, macrophages and intracellular iron deposits. Contrast-enhanced microCT represents a reliable and reproducible method for the longitudinal assessment of venous thrombus resolution providing powerful paired data. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Transcranial alternating current stimulation modulates auditory temporal resolution in elderly people.

PubMed

Baltus, Alina; Vosskuhl, Johannes; Boetzel, Cindy; Herrmann, Christoph Siegfried

2018-05-13

Recent research provides evidence for a functional role of brain oscillations for perception. For example, auditory temporal resolution seems to be linked to individual gamma frequency of auditory cortex. Individual gamma frequency not only correlates with performance in between-channel gap detection tasks but can be modulated via auditory transcranial alternating current stimulation. Modulation of individual gamma frequency is accompanied by an improvement in gap detection performance. Aging changes electrophysiological frequency components and sensory processing mechanisms. Therefore, we conducted a study to investigate the link between individual gamma frequency and gap detection performance in elderly people using auditory transcranial alternating current stimulation. In a within-subject design, twelve participants were electrically stimulated with two individualized transcranial alternating current stimulation frequencies: 3 Hz above their individual gamma frequency (experimental condition) and 4 Hz below their individual gamma frequency (control condition) while they were performing a between-channel gap detection task. As expected, individual gamma frequencies correlated significantly with gap detection performance at baseline and in the experimental condition, transcranial alternating current stimulation modulated gap detection performance. In the control condition, stimulation did not modulate gap detection performance. In addition, in elderly, the effect of transcranial alternating current stimulation on auditory temporal resolution seems to be dependent on endogenous frequencies in auditory cortex: elderlies with slower individual gamma frequencies and lower auditory temporal resolution profit from auditory transcranial alternating current stimulation and show increased gap detection performance during stimulation. Our results strongly suggest individualized transcranial alternating current stimulation protocols for successful modulation of performance. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

High-resolution dynamic 31 P-MRSI using a low-rank tensor model.

PubMed

Ma, Chao; Clifford, Bryan; Liu, Yuchi; Gu, Yuning; Lam, Fan; Yu, Xin; Liang, Zhi-Pei

2017-08-01

To develop a rapid 31 P-MRSI method with high spatiospectral resolution using low-rank tensor-based data acquisition and image reconstruction. The multidimensional image function of 31 P-MRSI is represented by a low-rank tensor to capture the spatial-spectral-temporal correlations of data. A hybrid data acquisition scheme is used for sparse sampling, which consists of a set of "training" data with limited k-space coverage to capture the subspace structure of the image function, and a set of sparsely sampled "imaging" data for high-resolution image reconstruction. An explicit subspace pursuit approach is used for image reconstruction, which estimates the bases of the subspace from the "training" data and then reconstructs a high-resolution image function from the "imaging" data. We have validated the feasibility of the proposed method using phantom and in vivo studies on a 3T whole-body scanner and a 9.4T preclinical scanner. The proposed method produced high-resolution static 31 P-MRSI images (i.e., 6.9 × 6.9 × 10 mm 3 nominal resolution in a 15-min acquisition at 3T) and high-resolution, high-frame-rate dynamic 31 P-MRSI images (i.e., 1.5 × 1.5 × 1.6 mm 3 nominal resolution, 30 s/frame at 9.4T). Dynamic spatiospectral variations of 31 P-MRSI signals can be efficiently represented by a low-rank tensor. Exploiting this mathematical structure for data acquisition and image reconstruction can lead to fast 31 P-MRSI with high resolution, frame-rate, and SNR. Magn Reson Med 78:419-428, 2017. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

A digital correlator upgrade for the Arcminute MicroKelvin Imager

NASA Astrophysics Data System (ADS)

Hickish, Jack; Razavi-Ghods, Nima; Perrott, Yvette C.; Titterington, David J.; Carey, Steve H.; Scott, Paul F.; Grainge, Keith J. B.; Scaife, Anna M. M.; Alexander, Paul; Saunders, Richard D. E.; Crofts, Mike; Javid, Kamran; Rumsey, Clare; Jin, Terry Z.; Ely, John A.; Shaw, Clive; Northrop, Ian G.; Pooley, Guy; D'Alessandro, Robert; Doherty, Peter; Willatt, Greg P.

2018-04-01

The Arcminute Microkelvin Imager (AMI) telescopes located at the Mullard Radio Astronomy Observatory near Cambridge have been significantly enhanced by the implementation of a new digital correlator with 1.2 MHz spectral resolution. This system has replaced a 750-MHz resolution analogue lag-based correlator, and was designed to mitigate the effects of radio frequency interference, particularly that from geostationary satellites which are visible from the AMI site when observing at low declinations. The upgraded instrument consists of 18 ROACH2 Field Programmable Gate Array platforms used to implement a pair of real-time FX correlators - one for each of AMI's two arrays. The new system separates the down-converted RF baseband signal from each AMI receiver into two sub-bands, each of which are filtered to a width of 2.3 GHz and digitized at 5-Gsps with 8 bits of precision. These digital data streams are filtered into 2048 frequency channels and cross-correlated using FPGA hardware, with a commercial 10 Gb Ethernet switch providing high-speed data interconnect. Images formed using data from the new digital correlator show over an order of magnitude improvement in dynamic range over the previous system. The ability to observe at low declinations has also been significantly improved.

Landscape correlates of forest plant invasions: A high-resolution analysis across the eastern United States

Treesearch

Kurt Riitters; Kevin Potter; Basil V. Iannone; Christopher Oswalt; Songlin Fei; Qinfeng Guo

2017-01-01

Aim: Invasive species occurrence is often related to the anthropogenic context of a given area. Quantifying the effects of roads is of particular interest as roads are a major vector for invasion. Our objective was to further quantify the effects of roads on forest plant invasion through a macroscale, high-resolution investigation to assist...

Range detection using entangled optical photons

NASA Astrophysics Data System (ADS)

Brandsema, Matthew J.; Narayanan, Ram M.; Lanzagorta, Marco

2015-05-01

Quantum radar is an emerging field that shows a lot of promise in providing significantly improved resolution compared to its classical radar counterpart. The key to this kind of resolution lies in the correlations created from the entanglement of the photons being used. Currently, the technology available only supports quantum radar implementation and validation in the optical regime, as opposed to the microwave regime, because microwave photons have very low energy compared to optical photons. Furthermore, there currently do not exist practical single photon detectors and generators in the microwave spectrum. Viable applications in the optical regime include deep sea target detection and high resolution detection in space. In this paper, we propose a conceptual architecture of a quantum radar which uses entangled optical photons based on Spontaneous Parametric Down Conversion (SPDC) methods. After the entangled photons are created and emerge from the crystal, the idler photon is detected very shortly thereafter. At the same time, the signal photon is sent out towards the target and upon its reflection will impinge on the detector of the radar. From these two measurements, correlation data processing is done to obtain the distance of the target away from the radar. Various simulations are then shown to display the resolution that is possible.

High-resolution local gravity model of the south pole of the Moon from GRAIL extended mission data.

PubMed

Goossens, Sander; Sabaka, Terence J; Nicholas, Joseph B; Lemoine, Frank G; Rowlands, David D; Mazarico, Erwan; Neumann, Gregory A; Smith, David E; Zuber, Maria T

2014-05-28

We estimated a high-resolution local gravity field model over the south pole of the Moon using data from the Gravity Recovery and Interior Laboratory's extended mission. Our solution consists of adjustments with respect to a global model expressed in spherical harmonics. The adjustments are expressed as gridded gravity anomalies with a resolution of 1/6° by 1/6° (equivalent to that of a degree and order 1080 model in spherical harmonics), covering a cap over the south pole with a radius of 40°. The gravity anomalies have been estimated from a short-arc analysis using only Ka-band range-rate (KBRR) data over the area of interest. We apply a neighbor-smoothing constraint to our solution. Our local model removes striping present in the global model; it reduces the misfit to the KBRR data and improves correlations with topography to higher degrees than current global models. We present a high-resolution gravity model of the south pole of the Moon Improved correlations with topography to higher degrees than global models Improved fits to the data and reduced striping that is present in global models.

High-resolution local gravity model of the south pole of the Moon from GRAIL extended mission data

PubMed Central

Goossens, Sander; Sabaka, Terence J; Nicholas, Joseph B; Lemoine, Frank G; Rowlands, David D; Mazarico, Erwan; Neumann, Gregory A; Smith, David E; Zuber, Maria T

2014-01-01

We estimated a high-resolution local gravity field model over the south pole of the Moon using data from the Gravity Recovery and Interior Laboratory's extended mission. Our solution consists of adjustments with respect to a global model expressed in spherical harmonics. The adjustments are expressed as gridded gravity anomalies with a resolution of 1/6° by 1/6° (equivalent to that of a degree and order 1080 model in spherical harmonics), covering a cap over the south pole with a radius of 40°. The gravity anomalies have been estimated from a short-arc analysis using only Ka-band range-rate (KBRR) data over the area of interest. We apply a neighbor-smoothing constraint to our solution. Our local model removes striping present in the global model; it reduces the misfit to the KBRR data and improves correlations with topography to higher degrees than current global models. Key Points We present a high-resolution gravity model of the south pole of the Moon Improved correlations with topography to higher degrees than global models Improved fits to the data and reduced striping that is present in global models PMID:26074637

High-resolution maps of real and illusory tactile activation in primary somatosensory cortex in individual monkeys with functional magnetic resonance imaging and optical imaging.

PubMed

Chen, Li M; Turner, Gregory H; Friedman, Robert M; Zhang, Na; Gore, John C; Roe, Anna W; Avison, Malcolm J

2007-08-22

Although blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has been widely used to explore human brain function, questions remain regarding the ultimate spatial resolution of positive BOLD fMRI, and indeed the extent to which functional maps revealed by positive BOLD correlate spatially with maps obtained with other high-spatial-resolution mapping techniques commonly used in animals, such as optical imaging of intrinsic signal (OIS) and single-unit electrophysiology. Here, we demonstrate that the positive BOLD signal at 9.4T can reveal the fine topography of individual fingerpads in single-condition activation maps in nonhuman primates. These digit maps are similar to maps obtained from the same animal using intrinsic optical imaging. Furthermore, BOLD fMRI reliably resolved submillimeter spatial shifts in activation in area 3b previously identified with OIS (Chen et al., 2003) as neural correlates of the "funneling illusion." These data demonstrate that at high field, high-spatial-resolution topographic maps can be achieved using the positive BOLD signal, weakening previous notions regarding the spatial specificity of the positive BOLD signal.

Modeling vegetation heights from high resolution stereo aerial photography: an application for broad-scale rangeland monitoring.

PubMed

Gillan, Jeffrey K; Karl, Jason W; Duniway, Michael; Elaksher, Ahmed

2014-11-01

Vertical vegetation structure in rangeland ecosystems can be a valuable indicator for assessing rangeland health and monitoring riparian areas, post-fire recovery, available forage for livestock, and wildlife habitat. Federal land management agencies are directed to monitor and manage rangelands at landscapes scales, but traditional field methods for measuring vegetation heights are often too costly and time consuming to apply at these broad scales. Most emerging remote sensing techniques capable of measuring surface and vegetation height (e.g., LiDAR or synthetic aperture radar) are often too expensive, and require specialized sensors. An alternative remote sensing approach that is potentially more practical for managers is to measure vegetation heights from digital stereo aerial photographs. As aerial photography is already commonly used for rangeland monitoring, acquiring it in stereo enables three-dimensional modeling and estimation of vegetation height. The purpose of this study was to test the feasibility and accuracy of estimating shrub heights from high-resolution (HR, 3-cm ground sampling distance) digital stereo-pair aerial images. Overlapping HR imagery was taken in March 2009 near Lake Mead, Nevada and 5-cm resolution digital surface models (DSMs) were created by photogrammetric methods (aerial triangulation, digital image matching) for twenty-six test plots. We compared the heights of individual shrubs and plot averages derived from the DSMs to field measurements. We found strong positive correlations between field and image measurements for several metrics. Individual shrub heights tended to be underestimated in the imagery, however, accuracy was higher for dense, compact shrubs compared with shrubs with thin branches. Plot averages of shrub height from DSMs were also strongly correlated to field measurements but consistently underestimated. Grasses and forbs were generally too small to be detected with the resolution of the DSMs. Estimates of vertical structure will be more accurate in plots having low herbaceous cover and high amounts of dense shrubs. Through the use of statistically derived correction factors or choosing field methods that better correlate with the imagery, vegetation heights from HR DSMs could be a valuable technique for broad-scale rangeland monitoring needs. Copyright © 2014 Elsevier Ltd. All rights reserved.

Modeling vegetation heights from high resolution stereo aerial photography: an application for broad-scale rangeland monitoring

USGS Publications Warehouse

Gillan, Jeffrey K.; Karl, Jason W.; Duniway, Michael; Elaksher, Ahmed

2014-01-01

Vertical vegetation structure in rangeland ecosystems can be a valuable indicator for assessing rangeland health and monitoring riparian areas, post-fire recovery, available forage for livestock, and wildlife habitat. Federal land management agencies are directed to monitor and manage rangelands at landscapes scales, but traditional field methods for measuring vegetation heights are often too costly and time consuming to apply at these broad scales. Most emerging remote sensing techniques capable of measuring surface and vegetation height (e.g., LiDAR or synthetic aperture radar) are often too expensive, and require specialized sensors. An alternative remote sensing approach that is potentially more practical for managers is to measure vegetation heights from digital stereo aerial photographs. As aerial photography is already commonly used for rangeland monitoring, acquiring it in stereo enables three-dimensional modeling and estimation of vegetation height. The purpose of this study was to test the feasibility and accuracy of estimating shrub heights from high-resolution (HR, 3-cm ground sampling distance) digital stereo-pair aerial images. Overlapping HR imagery was taken in March 2009 near Lake Mead, Nevada and 5-cm resolution digital surface models (DSMs) were created by photogrammetric methods (aerial triangulation, digital image matching) for twenty-six test plots. We compared the heights of individual shrubs and plot averages derived from the DSMs to field measurements. We found strong positive correlations between field and image measurements for several metrics. Individual shrub heights tended to be underestimated in the imagery, however, accuracy was higher for dense, compact shrubs compared with shrubs with thin branches. Plot averages of shrub height from DSMs were also strongly correlated to field measurements but consistently underestimated. Grasses and forbs were generally too small to be detected with the resolution of the DSMs. Estimates of vertical structure will be more accurate in plots having low herbaceous cover and high amounts of dense shrubs. Through the use of statistically derived correction factors or choosing field methods that better correlate with the imagery, vegetation heights from HR DSMs could be a valuable technique for broad-scale rangeland monitoring needs.

Optical coherence tomography of the eye

NASA Astrophysics Data System (ADS)

Hee, Michael Richard

1997-10-01

Optical Coherence Tomography (OCT) is a new technique for high-resolution, cross-sectional imaging of tissue in which the time-of-flight delay of light reflected from internal tissue structures is resolved with high precision using interferometry. Tomographic images are obtained which are analogous to those provided by ultrasound except that image contrast relies on differences in optical rather than acoustic properties of tissue. The use of light rather than sound enables higher resolution (10 μm) and non-contact imaging. A clinically viable high-sensitivity, fiber-optic based OCT instrument has been constructed based on engineering principles derived from optical communication theory. Computer algorithms have also been developed for quantitative image analysis and restoration. OCT has been used to image patients with a variety of ocular diseases. In patients with macular pathology, OCT images have been correlated with conventional clinical examination and fluorescein angiography. Optical coherence tomograms are effective in staging macular holes, evaluating the vitreoretinal interface in eyes at risk for a macular hole, and providing a structural assessment of macular hole surgery. In eyes with central serous chorioretinopathy, OCT can evaluate sensory retinal separations undetected at the slit-lamp. Serial OCT images of macular edema are able to track both the progression of macular thickening and the resolution of macular edema following laser photocoagulation. In patients with diabetic retinopathy, measurements of macular thickness correlate with visual acuity and OCT is more sensitive to small changes in retinal thickness than slit-lamp biomicroscopy. OCT may provide a novel method of defining occult choroidal neovascular membranes in patients with age-related macular degeneration. OCT can also profile the thickness of the retinal nerve fiber layer with high resolution which is potentially important for the objective assessment of early glaucoma progression. OCT images have been correlated with visual field performance and optic nerve appearance in a cross- section of patients with various stages of glaucoma. These studies suggest that OCT has the potential to become an important diagnostic tool for the practicing ophthalmologist. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

Los Angeles megacity: a high-resolution land–atmosphere modelling system for urban CO 2 emissions

DOE PAGES

Feng, Sha; Lauvaux, Thomas; Newman, Sally; ...

2016-07-22

Megacities are major sources of anthropogenic fossil fuel CO 2 (FFCO 2) emissions. The spatial extents of these large urban systems cover areas of 10 000 km 2 or more with complex topography and changing landscapes. We present a high-resolution land–atmosphere modelling system for urban CO 2 emissions over the Los Angeles (LA) megacity area. The Weather Research and Forecasting (WRF)-Chem model was coupled to a very high-resolution FFCO 2 emission product, Hestia-LA, to simulate atmospheric CO 2 concentrations across the LA megacity at spatial resolutions as fine as ~1 km. We evaluated multiple WRF configurations, selecting one that minimizedmore » errors in wind speed, wind direction, and boundary layer height as evaluated by its performance against meteorological data collected during the CalNex-LA campaign (May–June 2010). Our results show no significant difference between moderate-resolution (4 km) and high-resolution (1.3 km) simulations when evaluated against surface meteorological data, but the high-resolution configurations better resolved planetary boundary layer heights and vertical gradients in the horizontal mean winds. We coupled our WRF configuration with the Vulcan 2.2 (10 km resolution) and Hestia-LA (1.3 km resolution) fossil fuel CO 2 emission products to evaluate the impact of the spatial resolution of the CO 2 emission products and the meteorological transport model on the representation of spatiotemporal variability in simulated atmospheric CO 2 concentrations. We find that high spatial resolution in the fossil fuel CO 2 emissions is more important than in the atmospheric model to capture CO 2 concentration variability across the LA megacity. Finally, we present a novel approach that employs simultaneous correlations of the simulated atmospheric CO 2 fields to qualitatively evaluate the greenhouse gas measurement network over the LA megacity. Spatial correlations in the atmospheric CO 2 fields reflect the coverage of individual measurement sites when a statistically significant number of sites observe emissions from a specific source or location. We conclude that elevated atmospheric CO 2 concentrations over the LA megacity are composed of multiple fine-scale plumes rather than a single homogenous urban dome. Furthermore, we conclude that FFCO 2 emissions monitoring in the LA megacity requires FFCO 2 emissions modelling with ~1 km resolution because coarser-resolution emissions modelling tends to overestimate the observational constraints on the emissions estimates.« less

Los Angeles megacity: a high-resolution land–atmosphere modelling system for urban CO 2 emissions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng, Sha; Lauvaux, Thomas; Newman, Sally

Megacities are major sources of anthropogenic fossil fuel CO 2 (FFCO 2) emissions. The spatial extents of these large urban systems cover areas of 10 000 km 2 or more with complex topography and changing landscapes. We present a high-resolution land–atmosphere modelling system for urban CO 2 emissions over the Los Angeles (LA) megacity area. The Weather Research and Forecasting (WRF)-Chem model was coupled to a very high-resolution FFCO 2 emission product, Hestia-LA, to simulate atmospheric CO 2 concentrations across the LA megacity at spatial resolutions as fine as ~1 km. We evaluated multiple WRF configurations, selecting one that minimizedmore » errors in wind speed, wind direction, and boundary layer height as evaluated by its performance against meteorological data collected during the CalNex-LA campaign (May–June 2010). Our results show no significant difference between moderate-resolution (4 km) and high-resolution (1.3 km) simulations when evaluated against surface meteorological data, but the high-resolution configurations better resolved planetary boundary layer heights and vertical gradients in the horizontal mean winds. We coupled our WRF configuration with the Vulcan 2.2 (10 km resolution) and Hestia-LA (1.3 km resolution) fossil fuel CO 2 emission products to evaluate the impact of the spatial resolution of the CO 2 emission products and the meteorological transport model on the representation of spatiotemporal variability in simulated atmospheric CO 2 concentrations. We find that high spatial resolution in the fossil fuel CO 2 emissions is more important than in the atmospheric model to capture CO 2 concentration variability across the LA megacity. Finally, we present a novel approach that employs simultaneous correlations of the simulated atmospheric CO 2 fields to qualitatively evaluate the greenhouse gas measurement network over the LA megacity. Spatial correlations in the atmospheric CO 2 fields reflect the coverage of individual measurement sites when a statistically significant number of sites observe emissions from a specific source or location. We conclude that elevated atmospheric CO 2 concentrations over the LA megacity are composed of multiple fine-scale plumes rather than a single homogenous urban dome. Furthermore, we conclude that FFCO 2 emissions monitoring in the LA megacity requires FFCO 2 emissions modelling with ~1 km resolution because coarser-resolution emissions modelling tends to overestimate the observational constraints on the emissions estimates.« less

Incoherent Diffractive Imaging via Intensity Correlations of Hard X Rays

NASA Astrophysics Data System (ADS)

Classen, Anton; Ayyer, Kartik; Chapman, Henry N.; Röhlsberger, Ralf; von Zanthier, Joachim

2017-08-01

Established x-ray diffraction methods allow for high-resolution structure determination of crystals, crystallized protein structures, or even single molecules. While these techniques rely on coherent scattering, incoherent processes like fluorescence emission—often the predominant scattering mechanism—are generally considered detrimental for imaging applications. Here, we show that intensity correlations of incoherently scattered x-ray radiation can be used to image the full 3D arrangement of the scattering atoms with significantly higher resolution compared to conventional coherent diffraction imaging and crystallography, including additional three-dimensional information in Fourier space for a single sample orientation. We present a number of properties of incoherent diffractive imaging that are conceptually superior to those of coherent methods.

Super-resolution reconstruction in frequency, image, and wavelet domains to reduce through-plane partial voluming in MRI.

PubMed

Gholipour, Ali; Afacan, Onur; Aganj, Iman; Scherrer, Benoit; Prabhu, Sanjay P; Sahin, Mustafa; Warfield, Simon K

2015-12-01

To compare and evaluate the use of super-resolution reconstruction (SRR), in frequency, image, and wavelet domains, to reduce through-plane partial voluming effects in magnetic resonance imaging. The reconstruction of an isotropic high-resolution image from multiple thick-slice scans has been investigated through techniques in frequency, image, and wavelet domains. Experiments were carried out with thick-slice T2-weighted fast spin echo sequence on the Academic College of Radiology MRI phantom, where the reconstructed images were compared to a reference high-resolution scan using peak signal-to-noise ratio (PSNR), structural similarity image metric (SSIM), mutual information (MI), and the mean absolute error (MAE) of image intensity profiles. The application of super-resolution reconstruction was then examined in retrospective processing of clinical neuroimages of ten pediatric patients with tuberous sclerosis complex (TSC) to reduce through-plane partial voluming for improved 3D delineation and visualization of thin radial bands of white matter abnormalities. Quantitative evaluation results show improvements in all evaluation metrics through super-resolution reconstruction in the frequency, image, and wavelet domains, with the highest values obtained from SRR in the image domain. The metric values for image-domain SRR versus the original axial, coronal, and sagittal images were PSNR = 32.26 vs 32.22, 32.16, 30.65; SSIM = 0.931 vs 0.922, 0.924, 0.918; MI = 0.871 vs 0.842, 0.844, 0.831; and MAE = 5.38 vs 7.34, 7.06, 6.19. All similarity metrics showed high correlations with expert ranking of image resolution with MI showing the highest correlation at 0.943. Qualitative assessment of the neuroimages of ten TSC patients through in-plane and out-of-plane visualization of structures showed the extent of partial voluming effect in a real clinical scenario and its reduction using SRR. Blinded expert evaluation of image resolution in resampled out-of-plane views consistently showed the superiority of SRR compared to original axial and coronal image acquisitions. Thick-slice 2D T2-weighted MRI scans are part of many routine clinical protocols due to their high signal-to-noise ratio, but are often severely affected by through-plane partial voluming effects. This study shows that while radiologic assessment is performed in 2D on thick-slice scans, super-resolution MRI reconstruction techniques can be used to fuse those scans to generate a high-resolution image with reduced partial voluming for improved postacquisition processing. Qualitative and quantitative evaluation showed the efficacy of all SRR techniques with the best results obtained from SRR in the image domain. The limitations of SRR techniques are uncertainties in modeling the slice profile, density compensation, quantization in resampling, and uncompensated motion between scans.

Bronchiectasis: correlation of high-resolution CT findings with health-related quality of life.

PubMed

Eshed, I; Minski, I; Katz, R; Jones, P W; Priel, I E

2007-02-01

To evaluate the relationship between the severity of bronchiectatic diseases, as evident on high-resolution computed tomography (HRCT) and the patient's quality of life measured using the St George's Respiratory Questionnaire (SGRQ). Forty-six patients (25 women, 21 men, mean age: 63 years) with bronchiectatic disease as evident on recent HRCT examinations were recruited. Each patient completed the SGRQ and underwent respiratory function tests. HRCT findings were blindly and independently scored by two radiologists, using the modified Bhalla scoring system. The relationships between HRCT scores, SGRQ scores and pulmonary function tests were evaluated. The patients' total CT score did not correlate with the SGRQ scores. However, patients with more advanced disease on HRCT, significantly differed in their SGRQ scores from patients with milder bronchiectatic disease. A significant correlation was found between the CT scores for the middle and distal lung zones and the activity, impacts and total SGRQ scores. No correlation was found between CT scores and respiratory function test indices. However, a significant correlation was found between the SGRQ scores and most of the respiratory function test indices. A correlation between the severity of bronchiectatic disease as expressed in HRCT and the health-related quality of life exists in patients with a more severe bronchiectatic disease but not in patients with mild disease. Such correlation depends on the location of the bronchiectasis in the pulmonary tree.

Revisiting Melton: Analyzing the correlation structure of geomorphological and climatological parameters

NASA Astrophysics Data System (ADS)

Carothers, R. A.; Sangireddy, H.; Passalacqua, P.

2013-12-01

In his expansive 1957 study of over 80 basins in Arizona, Colorado, New Mexico, and Utah, Mark Melton measured key morphometric, soil, land cover, and climatic parameters [Melton, 1957]. He identified correlations between morphological parameters and climatic regimes in an attempt to characterize the geomorphology of the basin as a function of climate and vegetation. Using modern techniques such as high resolution digital terrain models in combination with high spatial resolution weather station records, vector soil maps, seamless raster geological data, and land cover vector maps, we revisit Melton's 1957 dataset with the following hypotheses: (1) Patterns of channelization carry strong, codependent signatures in the form of statistical correlations of rainfall variability, soil type, and vegetation patterns. (2) Channelization patterns reflect the erosion processes on sub-catchment scale and the subsequent processes of vegetation recovery and gullying. In order to characterize various topographic and climatic parameters, we obtain elevation and land cover data from the USGS National Elevation dataset, climate data from the Western Regional Climate Center and PRISM climate group database, and soil type from the USDA STATSGO soil database. We generate a correlative high resolution database on vegetation, soil cover, lithology, and climatology for the basins identified by Melton in his 1957 study. Using the GeoNet framework developed by Passalacqua et al. [2010], we extract various morphological parameters such as slope, drainage density, and stream frequency. We also calculate metrics for patterns of channelization such as number of channelized pixels in a basin and channel head density. In order to understand the correlation structure between climate and morphological variables, we compute the Pearson's correlation coefficient similar to Melton's analysis and also explore other statistical procedures to characterize the feedbacks between these variables. By identifying the differences in Melton's and our results, we address the influence of climate over the degree of channel dissection in the landscape. References: Melton, M. A. (1957). An analysis of the relations among elements of climate, surface properties, and geomorphology (No. CU-TR-11). COLUMBIA UNIV NEW YORK Passalacqua, P., Do Trung, T., Foufoula-Georgiou, E., Sapiro, G., & Dietrich, W. E. (2010). A geometric framework for channel network extraction from lidar: Nonlinear diffusion and geodesic paths. Journal of Geophysical Research: Earth Surface (2003-2012), 115(F1). PRISM Climate Group, Oregon State University, http://prism.oregonstate.edu, created 4 Feb 2004 Soil Survey Staff, Natural Resources Conservation Service, United States Department of Agriculture. U.S. General Soil Map (STATSGO2). Available online at http://soildatamart.nrcs.usda.gov USGS National Map Viewer, United States Geological Survey. Web. 10 June 2013. http://viewer.nationalmap.gov/viewer/ Western U.S. Historical Climate Summaries, Western Regional Climate Group, 2013. Web. 10 June 2013. http://www.wrcc.dri.edu/Climsum.html

Evaluation of Large Volume SrI2(Eu) Scintillator Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sturm, B W; Cherepy, N J; Drury, O B

2010-11-18

There is an ever increasing demand for gamma-ray detectors which can achieve good energy resolution, high detection efficiency, and room-temperature operation. We are working to address each of these requirements through the development of large volume SrI{sub 2}(Eu) scintillator detectors. In this work, we have evaluated a variety of SrI{sub 2} crystals with volumes >10 cm{sup 3}. The goal of this research was to examine the causes of energy resolution degradation for larger detectors and to determine what can be done to mitigate these effects. Testing both packaged and unpackaged detectors, we have consistently achieved better resolution with the packagedmore » detectors. Using a collimated gamma-ray source, it was determined that better energy resolution for the packaged detectors is correlated with better light collection uniformity. A number of packaged detectors were fabricated and tested and the best spectroscopic performance was achieved for a 3% Eu doped crystal with an energy resolution of 2.93% FWHM at 662keV. Simulations of SrI{sub 2}(Eu) crystals were also performed to better understand the light transport physics in scintillators and are reported. This study has important implications for the development of SrI{sub 2}(Eu) detectors for national security purposes.« less

Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis

PubMed Central

Leishman, Shaneen J.; Seymour, Gregory J.; Ford, Pauline J.

2013-01-01

This study profiled the local and systemic inflammatory responses to experimentally induced gingivitis. Eight females participated in a 21-day experimental gingivitis model followed by a 14-day resolution phase. Bleeding on probing and plaque index scores were assessed before, during, and after resolution of gingival inflammation, and samples of saliva, GCF, and plasma were collected. Samples were assessed for biomarkers of inflammation using the BioPlex platform and ELISA. There were no significant changes in GCF levels of cytokines during the experimental phase; however, individual variability in cytokine profiles was noted. During resolution, mean GCF levels of IL-2, IL-6, and TNF-α decreased and were significantly lower than baseline levels (P = 0.003, P = 0.025, and P = 0.007, resp.). Furthermore, changes in GCF levels of IL-2, IL-6, and TNF-α during resolution correlated with changes in plaque index scores (r = 0.88, P = 0.004; r = 0.72, P = 0.042; r = 0.79, P = 0.019, resp.). Plasma levels of sICAM-1 increased significantly during the experimental phase (P = 0.002) and remained elevated and significantly higher than baseline levels during resolution (P < 0.001). These results support the concept that gingivitis adds to the systemic inflammatory burden of an individual. PMID:24227893

Local and systemic inflammatory responses to experimentally induced gingivitis.

PubMed

Leishman, Shaneen J; Seymour, Gregory J; Ford, Pauline J

2013-01-01

This study profiled the local and systemic inflammatory responses to experimentally induced gingivitis. Eight females participated in a 21-day experimental gingivitis model followed by a 14-day resolution phase. Bleeding on probing and plaque index scores were assessed before, during, and after resolution of gingival inflammation, and samples of saliva, GCF, and plasma were collected. Samples were assessed for biomarkers of inflammation using the BioPlex platform and ELISA. There were no significant changes in GCF levels of cytokines during the experimental phase; however, individual variability in cytokine profiles was noted. During resolution, mean GCF levels of IL-2, IL-6, and TNF-α decreased and were significantly lower than baseline levels (P = 0.003, P = 0.025, and P = 0.007, resp.). Furthermore, changes in GCF levels of IL-2, IL-6, and TNF-α during resolution correlated with changes in plaque index scores (r = 0.88, P = 0.004; r = 0.72, P = 0.042; r = 0.79, P = 0.019, resp.). Plasma levels of sICAM-1 increased significantly during the experimental phase (P = 0.002) and remained elevated and significantly higher than baseline levels during resolution (P < 0.001). These results support the concept that gingivitis adds to the systemic inflammatory burden of an individual.

Correlation Functions Quantify Super-Resolution Images and Estimate Apparent Clustering Due to Over-Counting

PubMed Central

Veatch, Sarah L.; Machta, Benjamin B.; Shelby, Sarah A.; Chiang, Ethan N.; Holowka, David A.; Baird, Barbara A.

2012-01-01

We present an analytical method using correlation functions to quantify clustering in super-resolution fluorescence localization images and electron microscopy images of static surfaces in two dimensions. We use this method to quantify how over-counting of labeled molecules contributes to apparent self-clustering and to calculate the effective lateral resolution of an image. This treatment applies to distributions of proteins and lipids in cell membranes, where there is significant interest in using electron microscopy and super-resolution fluorescence localization techniques to probe membrane heterogeneity. When images are quantified using pair auto-correlation functions, the magnitude of apparent clustering arising from over-counting varies inversely with the surface density of labeled molecules and does not depend on the number of times an average molecule is counted. In contrast, we demonstrate that over-counting does not give rise to apparent co-clustering in double label experiments when pair cross-correlation functions are measured. We apply our analytical method to quantify the distribution of the IgE receptor (FcεRI) on the plasma membranes of chemically fixed RBL-2H3 mast cells from images acquired using stochastic optical reconstruction microscopy (STORM/dSTORM) and scanning electron microscopy (SEM). We find that apparent clustering of FcεRI-bound IgE is dominated by over-counting labels on individual complexes when IgE is directly conjugated to organic fluorophores. We verify this observation by measuring pair cross-correlation functions between two distinguishably labeled pools of IgE-FcεRI on the cell surface using both imaging methods. After correcting for over-counting, we observe weak but significant self-clustering of IgE-FcεRI in fluorescence localization measurements, and no residual self-clustering as detected with SEM. We also apply this method to quantify IgE-FcεRI redistribution after deliberate clustering by crosslinking with two distinct trivalent ligands of defined architectures, and we evaluate contributions from both over-counting of labels and redistribution of proteins. PMID:22384026

Evaluation of a 3D local multiresolution algorithm for the correction of partial volume effects in positron emission tomography.

PubMed

Le Pogam, Adrien; Hatt, Mathieu; Descourt, Patrice; Boussion, Nicolas; Tsoumpas, Charalampos; Turkheimer, Federico E; Prunier-Aesch, Caroline; Baulieu, Jean-Louis; Guilloteau, Denis; Visvikis, Dimitris

2011-09-01

Partial volume effects (PVEs) are consequences of the limited spatial resolution in emission tomography leading to underestimation of uptake in tissues of size similar to the point spread function (PSF) of the scanner as well as activity spillover between adjacent structures. Among PVE correction methodologies, a voxel-wise mutual multiresolution analysis (MMA) was recently introduced. MMA is based on the extraction and transformation of high resolution details from an anatomical image (MR/CT) and their subsequent incorporation into a low-resolution PET image using wavelet decompositions. Although this method allows creating PVE corrected images, it is based on a 2D global correlation model, which may introduce artifacts in regions where no significant correlation exists between anatomical and functional details. A new model was designed to overcome these two issues (2D only and global correlation) using a 3D wavelet decomposition process combined with a local analysis. The algorithm was evaluated on synthetic, simulated and patient images, and its performance was compared to the original approach as well as the geometric transfer matrix (GTM) method. Quantitative performance was similar to the 2D global model and GTM in correlated cases. In cases where mismatches between anatomical and functional information were present, the new model outperformed the 2D global approach, avoiding artifacts and significantly improving quality of the corrected images and their quantitative accuracy. A new 3D local model was proposed for a voxel-wise PVE correction based on the original mutual multiresolution analysis approach. Its evaluation demonstrated an improved and more robust qualitative and quantitative accuracy compared to the original MMA methodology, particularly in the absence of full correlation between anatomical and functional information.

Does objective cluster analysis serve as a useful precursor to seasonal precipitation prediction at local scale? Application to western Ethiopia

NASA Astrophysics Data System (ADS)

Zhang, Ying; Moges, Semu; Block, Paul

2018-01-01

Prediction of seasonal precipitation can provide actionable information to guide management of various sectoral activities. For instance, it is often translated into hydrological forecasts for better water resources management. However, many studies assume homogeneity in precipitation across an entire study region, which may prove ineffective for operational and local-level decisions, particularly for locations with high spatial variability. This study proposes advancing local-level seasonal precipitation predictions by first conditioning on regional-level predictions, as defined through objective cluster analysis, for western Ethiopia. To our knowledge, this is the first study predicting seasonal precipitation at high resolution in this region, where lives and livelihoods are vulnerable to precipitation variability given the high reliance on rain-fed agriculture and limited water resources infrastructure. The combination of objective cluster analysis, spatially high-resolution prediction of seasonal precipitation, and a modeling structure spanning statistical and dynamical approaches makes clear advances in prediction skill and resolution, as compared with previous studies. The statistical model improves versus the non-clustered case or dynamical models for a number of specific clusters in northwestern Ethiopia, with clusters having regional average correlation and ranked probability skill score (RPSS) values of up to 0.5 and 33 %, respectively. The general skill (after bias correction) of the two best-performing dynamical models over the entire study region is superior to that of the statistical models, although the dynamical models issue predictions at a lower resolution and the raw predictions require bias correction to guarantee comparable skills.

A comprehensive assessment of the correlations between field crop yields and commonly used MODIS products

NASA Astrophysics Data System (ADS)

Johnson, David M.

2016-10-01

An exploratory assessment was undertaken to determine the correlation strength and optimal timing of several commonly used Moderate Resolution Imaging Spectroradiometer (MODIS) composited imagery products against crop yields for 10 globally significant agricultural commodities. The crops analyzed included barley, canola, corn, cotton, potatoes, rice, sorghum, soybeans, sugarbeets, and wheat. The MODIS data investigated included the Normalized Difference Vegetation Index (NDVI), Fraction of Photosynthetically Active Radiation (FPAR), Leaf Area Index (LAI), and Gross Primary Production (GPP), in addition to daytime Land Surface Temperature (DLST) and nighttime LST (NLST). The imagery utilized all had 8-day time intervals, but NDVI had a 250 m spatial resolution while the other products were 1000 m. These MODIS datasets were also assessed from both the Terra and Aqua satellites, with their differing overpass times, to document any differences. A follow-on analysis, using the Terra 250 m NDVI data as a benchmark, looked at the yield prediction utility of NDVI at two spatial scales (250 m vs. 1000 m), two time precisions (8-day vs. 16-day), and also assessed the Enhanced Vegetation Index (EVI, at 250 m, 16-day). The analyses spanned the major farming areas of the United States (US) from the summers of 2008-2013 and used annual county-level average crop yield data from the US Department of Agriculture as a basis. All crops, except rice, showed at least some positive correlations to each of the vegetation related indices in the middle of the growing season, with NDVI performing slightly better than FPAR. LAI was somewhat less strongly correlated and GPP weak overall. Conversely, some of the crops, particularly canola, corn, and soybeans, also showed negative correlations to DLST mid-summer. NLST, however, was never correlated to crop yield, regardless of the crop or seasonal timing. Differences between the Terra and Aqua results were found to be minimal. The 1000 m resolution NDVI showed somewhat poorer performance than the 250 m and suggests spatial resolution is helpful but not a necessity. The 8-day versus 16-day NDVI relationships to yields were very similar other than for the temporal precision. Finally, the EVI often showed the very best performance of all the variables, all things considered.

An investigation of the oxidation behaviour of zirconium alloys using isotopic tracers and high resolution SIMS

NASA Astrophysics Data System (ADS)

Yardley, Sean S.; Moore, Katie L.; Ni, Na; Wei, Jang Fei; Lyon, Stuart; Preuss, Michael; Lozano-Perez, Sergio; Grovenor, Chris R. M.

2013-11-01

High resolution secondary ion mass spectrometry (SIMS) analysis has been used to study the oxidation mechanisms when commercial low tin ZIRLO™Low tin ZIRLO™ is a trademark of Westinghouse Electric Company LLC in the United States and may be registered in other countries throughout the world. Unauthorized use is strictly prohibited.1 and Zircaloy 4 materials are exposed to corroding environments containing both 18O and 2H isotopes. Clear evidence has been shown for different characteristic distributions of 18O before and after the kinetic transitions, and this behaviour has been correlated with the development of porosity in the oxide which allows the corroding medium to penetrate locally to the metal/oxide interface.

Dynamic adjustments of cognitive control during economic decision making.

PubMed

Soutschek, Alexander; Schubert, Torsten

2014-10-01

Decision making in the Ultimatum game requires the resolution of conflicts between economic self-interest and fairness intuitions. Since cognitive control processes play an important role in conflict resolution, the present study examined how control processes that are triggered by conflicts between fairness and self-interest in unfair offers affect subsequent decisions in the Ultimatum game. Our results revealed that more unfair offers were accepted following previously unfair, compared to previously fair offers. Interestingly, the magnitude of this conflict adaptation effect correlated with the individual subjects' focus on economic self-interest. We concluded that conflicts between fairness and self-interest trigger cognitive control processes, which reinforce the focus on the current task goal. Copyright © 2014 Elsevier B.V. All rights reserved.

Observing laser ablation dynamics with sub-picosecond temporal resolution

NASA Astrophysics Data System (ADS)

Tani, Shuntaro; Kobayashi, Yohei

2017-04-01

Laser ablation is one of the most fundamental processes in laser processing, and the understanding of its dynamics is of key importance for controlling and manipulating the outcome. In this study, we propose a novel way of observing the dynamics in the time domain using an electro-optic sampling technique. We found that an electromagnetic field was emitted during the laser ablation process and that the amplitude of the emission was closely correlated with the ablated volume. From the temporal profile of the electromagnetic field, we analyzed the motion of charged particles with subpicosecond temporal resolution. The proposed method can provide new access to observing laser ablation dynamics and thus open a new way to optimize the laser processing.

Exploring psychosocial task resolution and self-concept among African-American adolescents.

PubMed

Brookins, C C

1996-06-01

Developmental task resolution and self-concept of adolescents were examined for a sample of 110 African-American youth. The Erikson Psychosocial Stage Inventory was used to measure Erikson's stages of psychological development and the Bronstein-Cruz Child/Adolescent Self-concept and Adjustment Scale was used to measure multiple components of the self-concept. Scores for Self-concept and Resolution of Identity stages were highly correlated although scores on Resolution of Identity, commonly seen as the primary psychosocial task of adolescence, were not related to scores on either Emotional Well-being or Family Relations. The results are discussed in terms of improving understanding of relationships between processes in development, identity, and other salient psychosocial variables.