Sample records for responsive space ors

  1. Responsive space: Concept analysis and theoretical framework

    NASA Astrophysics Data System (ADS)

    Saleh, Joseph H.; Dubos, Gregory F.

    2009-08-01

    Customers' needs are dynamic and evolve in response to unfolding environmental uncertainties. The ability of a company or an industry to address these changing customers' needs in a timely and cost-effective way is a measure of its responsiveness. In the space industry, a systemic discrepancy exists between the time constants associated with the change of customers' needs, and the response time of the industry in delivering on-orbit solutions to these needs. There are important penalties associated with such delays, and space responsiveness is recognized as a strategic imperative in commercial competitive and military environments. In this paper, we provide a critical assessment of the literature on responsive space and introduce a new multi-disciplinary framework for thinking about and addressing issues of space responsiveness. Our framework advocates three levels of responsiveness: a global industry-wide responsiveness, a local stakeholder responsiveness, and an interactive or inter-stakeholder responsiveness. We introduce and motivate the use of "responsiveness maps" for multiple stakeholders. We then identify "levers of responsiveness": technical spacecraft- and launch-centric, as well as "soft" levers (e.g., acquisition policies) for improving the responsiveness of the space industry. Finally, we propose a series of research questions to aggressively tackle problems associated with space responsiveness.

  2. Development and Application of Methods for Estimating Operating Characteristics of Discrete Test Item Responses without Assuming any Mathematical Form.

    ERIC Educational Resources Information Center

    Samejima, Fumiko

    In latent trait theory the latent space, or space of the hypothetical construct, is usually represented by some unidimensional or multi-dimensional continuum of real numbers. Like the latent space, the item response can either be treated as a discrete variable or as a continuous variable. Latent trait theory relates the item response to the latent…

  3. 14 CFR 1204.1002 - Responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Responsibility. 1204.1002 Section 1204.1002 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ADMINISTRATIVE AUTHORITY AND POLICY Inspection of Persons and Personal Effects at NASA Installations or on NASA Property; Trespass or...

  4. 14 CFR 1204.1002 - Responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Responsibility. 1204.1002 Section 1204.1002 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ADMINISTRATIVE AUTHORITY AND POLICY Inspection of Persons and Personal Effects at NASA Installations or on NASA Property; Trespass or...

  5. A survey of of uses and value of space weather information

    NASA Astrophysics Data System (ADS)

    Schrijver, C. J.; Rabanal, J.

    2013-12-01

    We analyze some 2,800 responses to a survey among subscribers of NOAA's Space Weather Prediction Center email services. Interest in, anticipated impacts from, and responses to solar flares, energetic particle events, and geomagnetic storms are quite uniform across societal sectors. Approximately 40% of the respondents expect serious to very serious impacts from space weather events if no action were taken to mitigate or in the absence of adequate space weather information. The impacts of space weather are deemed to be substantially reduced because of the availability of, and the response to, space-weather forecasts and alerts. Space weather information is primarily used as aid to understand anomalies, to implement mitigating strategies designed to avoid impacts on operations, and to prepare for potential contingencies related directly or indirectly to space weather. Current and near-future space-weather conditions are generally highly valued, considered useful, and generally, though not fully, adequate to avoid or mitigate societal impacts (related most frequently to human safety and reliability of operations). We conclude that even among those receiving space weather information, there is considerable uncertainty about how to act on the information provided.

  6. 14 CFR 1214.609 - Loss or theft.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Loss or theft. 1214.609 Section 1214.609... Flights § 1214.609 Loss or theft. (a) Responsibility. The National Aeronautics and Space Administration will not be responsible for the loss or theft of, or damage to, items carried in OFK's or PPK's. (b...

  7. The immune system in space, including Earth-based benefits of space-based research.

    PubMed

    Sonnenfeld, Gerald

    2005-08-01

    Exposure to space flight conditions has been shown to result in alterations in immune responses. Changes in immune responses of humans and experimental animals have been shown to be altered during and after space flight of humans and experimental animals or cell cultures of lymphoid cells. Exposure of subjects to ground-based models of space flight conditions, such as hindlimb unloading of rodents or chronic bed rest of humans, has also resulted in changes in the immune system. The relationship of these changes to compromised resistance to infection or tumors in space flight has not been fully established, but results from model systems suggest that alterations in the immune system that occur in space flight conditions may be related to decreases in resistance to infection. The establishment of such a relationship could lead to the development of countermeasures that could prevent or ameliorate any compromises in resistance to infection resulting from exposure to space flight conditions. An understanding of the mechanisms of space flight conditions effects on the immune response and development of countermeasures to prevent them could contribute to the development of treatments for compromised immunity on earth.

  8. 14 CFR 1203.601 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Responsibilities. 1203.601 Section 1203.601 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM... authority may declassify or downgrade information that is subject to the final classification jurisdiction...

  9. 14 CFR 1203.601 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Responsibilities. 1203.601 Section 1203.601 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM... authority may declassify or downgrade information that is subject to the final classification jurisdiction...

  10. 32 CFR 644.133 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... responsible for acquiring space in buildings, or land, or both land and buildings, under its own authority or... Army and Air Force; Department of the Navy, including the Marine Corps, for recruiting and main stations; Department of Energy and the Nuclear Regulatory Commission, excluding space in GSA urban centers...

  11. 32 CFR 644.133 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... responsible for acquiring space in buildings, or land, or both land and buildings, under its own authority or... Army and Air Force; Department of the Navy, including the Marine Corps, for recruiting and main stations; Department of Energy and the Nuclear Regulatory Commission, excluding space in GSA urban centers...

  12. 14 CFR 33.73 - Power or thrust response.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Power or thrust response. 33.73 Section 33.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.73 Power or...

  13. 14 CFR 33.73 - Power or thrust response.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Power or thrust response. 33.73 Section 33.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.73 Power or...

  14. 14 CFR 33.73 - Power or thrust response.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Power or thrust response. 33.73 Section 33.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.73 Power or...

  15. A survey of customers of space weather information

    NASA Astrophysics Data System (ADS)

    Schrijver, C. J.; Rabanal, J. P.

    2013-09-01

    We present an analysis of the users of space weather information based on 2783 responses to an online survey among subscribers of NOAA's Space Weather Prediction Center e-mail services. The survey requested information focused on the three NOAA space weather scales: geomagnetic storms, solar radiation storms, and radio blackouts. Space weather information is most commonly obtained for reasons of human safety and continuity or reliability of operations. The information is primarily used for situational awareness, as aid to understand anomalies, to avoid impacts on current and near-future operations by implementing mitigating strategies, and to prepare for potential near-future impacts that might occur in conjunction with contingencies that include electric power outages or GPS perturbations. Interest in, anticipated impacts from, and responses to the three main categories of space weather are quite uniform across societal sectors. Approximately 40% of the respondents expect serious to very serious impacts from space weather events if no action were taken to mitigate or in the absence of adequate space weather information. The impacts of space weather are deemed to be substantially reduced because of the availability of, and their response to, space weather forecasts and alerts. Current and near-future space weather conditions are generally highly valued, considered useful, and generally, though not fully, adequate to avoid or mitigate societal impacts. We conclude that even among those receiving space weather information, there is considerable uncertainty about the possible impacts of space weather and thus about how to act on the space weather information that is provided.

  16. Interplay of space radiation and microgravity in DNA damage and DNA damage response.

    PubMed

    Moreno-Villanueva, María; Wong, Michael; Lu, Tao; Zhang, Ye; Wu, Honglu

    2017-01-01

    In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms. Specifically, space radiation can cause damage to DNA directly, through the interaction of charged particles with the DNA molecules themselves, or indirectly through the production of free radicals. Although organisms have evolved strategies on Earth to confront such damage, space environmental conditions, especially microgravity, can impact DNA repair resulting in accumulation of severe DNA lesions. Ultimately these lesions, namely double strand breaks, chromosome aberrations, micronucleus formation, or mutations, can increase the risk for adverse health effects, such as cancer. How spaceflight factors affect DNA damage and the DNA damage response has been investigated since the early days of the human space program. Over the years, these experiments have been conducted either in space or using ground-based analogs. This review summarizes the evidence for DNA damage induction by space radiation and/or microgravity as well as spaceflight-related impacts on the DNA damage response. The review also discusses the conflicting results from studies aimed at addressing the question of potential synergies between microgravity and radiation with regard to DNA damage and cellular repair processes. We conclude that further experiments need to be performed in the true space environment in order to address this critical question.

  17. Immune responses in space flight

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, G.

    1998-01-01

    Space flight has been shown to have profound effects on immunological parameters of humans, monkeys and rodents. These studies have been carried out by a number of different laboratories. Among the parameters affected are leukocyte blastogenesis, natural killer cell activity, leukocyte subset distribution, cytokine production - including interferons and interleukins, and macrophage maturation and activity. These changes start to occur only after a few days space flight, and some changes continue throughout long-term space flight. Antibody responses have received only very limited study, and total antibody levels have been shown to be increased after long-term space flight. Several factors could be involved in inducing these changes. These factors could include microgravity, lack of load-bearing, stress, acceleration forces, and radiation. The mechanism(s) for space flight-induced changes in immune responses remain(s) to be established. Certainly, there can be direct effects of microgravity, or other factors, on cells that play a fundamental role in immune responses. However, it is now clear that there are interactions between the immune system and other physiological systems that could play a major role. For example, changes occurring in calcium use in the musculoskeletal system induced by microgravity or lack of use could have great impact on the immune system. Most of the changes in immune responses have been observed using samples taken immediately after return from space flight. However, there have been two recent studies that have used in-flight testing. Delayed-type hypersensitivity responses to common recall antigens of astronauts and cosmonauts have been shown to be decreased when tested during space flights. Additionally, natural killer cell and blastogenic activities are inhibited in samples taken from rats during space flight. Therefore, it is now clear that events occurring during space flight itself can affect immune responses. The biological significance of space flight-induced changes in immune parameters remains to be established; however, as duration of flights increases, the potential for difficulties due to impaired immune responses also increases.

  18. Models of anxiety: responses of rats to novelty in an open space and an enclosed space.

    PubMed

    Ennaceur, A; Michalikova, S; Chazot, P L

    2006-07-15

    Exposure to novelty has been shown to induce anxiety responses in a variety of behavioural paradigms. The purpose of the present study was to investigate whether exposition of naïve rats to novelty would result in a comparable or a different pattern of responses in an open space versus enclosed space with or without the presence of an object in the centre of the field. Lewis and Wistar rats of both genders were used to illustrate and discuss the value and validity of these anxiety paradigms. We examined a wide range of measures, which cover several aspects of animals' responses. The results of this study revealed significant differences between the behaviour of animals in an open space and in the enclosed space. It also revealed significant differences in animal's responses to the presence and absence of an object in the open space and in the enclosed space. In the enclosed space, rats spent most of their time in the outer area with lower number of exits and avoided the object area except when there was an object, while in the open space rats displayed frequent short duration re-entries in the outer area and spent longer time in the object area in presence of an object. The time spent in the inner area (away from the outer area and the object area) was significantly longer and the number of faecal boli was significantly higher in the open space than in the enclosed space. In the present report, we will discuss the fundamental differences between enclosed space and open space models, and we will examine some methodological issues related to the current animal models of human behaviour in anxiety. In the enclosed space, animals can avoid the potential threat associated with the centre area of a box and chose the safety of walls and corners, whereas, in the open space animals have to avoid every parts of the field from which there was no safe escape. The response of animals to novelty in an open space model appears more relevant to anxiety than in an enclosed space. The present studies revealed no correlations between the measures of behaviour in enclosed space and the measures of behaviour in open space, which suggest that these two models do not involve the same construct. Our results suggest that the enclosed space model involves avoidance responses while the open space model involves anxiety responses. The open space model can be very useful in understanding the underlying neural mechanisms of anxiety responses, and in assessing the effects of potential anxiolytic drugs.

  19. 14 CFR § 1274.933 - Summary of recipient reporting responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Summary of recipient reporting responsibilities. § 1274.933 Section § 1274.933 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE... Transfer of Technology Prior to transferring technology to foreign firm or institution 1274.915...

  20. 14 CFR § 1214.609 - Loss or theft.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Space Shuttle Flights § 1214.609 Loss or theft. (a) Responsibility. The National Aeronautics and Space... missing shall immediately report the loss to the Johnson Space Center Security Office and the NASA...

  1. 41 CFR 102-85.80 - Who is financially responsible for expenses resulting from tenant non-performance?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OA. Customer agencies are also financially responsible for revised design costs and any additional costs resulting from changes to space requirements or space layouts made by the agency after a lease, alteration, design, or construction contract has been awarded by GSA. ...

  2. 41 CFR 102-85.80 - Who is financially responsible for expenses resulting from tenant non-performance?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OA. Customer agencies are also financially responsible for revised design costs and any additional costs resulting from changes to space requirements or space layouts made by the agency after a lease, alteration, design, or construction contract has been awarded by GSA. ...

  3. 41 CFR 102-85.80 - Who is financially responsible for expenses resulting from tenant non-performance?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OA. Customer agencies are also financially responsible for revised design costs and any additional costs resulting from changes to space requirements or space layouts made by the agency after a lease, alteration, design, or construction contract has been awarded by GSA. ...

  4. 41 CFR 102-85.80 - Who is financially responsible for expenses resulting from tenant non-performance?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OA. Customer agencies are also financially responsible for revised design costs and any additional costs resulting from changes to space requirements or space layouts made by the agency after a lease, alteration, design, or construction contract has been awarded by GSA. ...

  5. 41 CFR 102-85.80 - Who is financially responsible for expenses resulting from tenant non-performance?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OA. Customer agencies are also financially responsible for revised design costs and any additional costs resulting from changes to space requirements or space layouts made by the agency after a lease, alteration, design, or construction contract has been awarded by GSA. ...

  6. On the response of halophilic archaea to space conditions.

    PubMed

    Leuko, Stefan; Rettberg, Petra; Pontifex, Ashleigh L; Burns, Brendan P

    2014-02-21

    Microorganisms are ubiquitous and can be found in almost every habitat and ecological niche on Earth. They thrive and survive in a broad spectrum of environments and adapt to rapidly changing external conditions. It is of great interest to investigate how microbes adapt to different extreme environments and with modern human space travel, we added a new extreme environment: outer space. Within the last 50 years, technology has provided tools for transporting microbial life beyond Earth's protective shield in order to study in situ responses to selected conditions of space. This review will focus on halophilic archaea, as, due to their ability to survive in extremes, they are often considered a model group of organisms to study responses to the harsh conditions associated with space. We discuss ground-based simulations, as well as space experiments, utilizing archaea, examining responses and/or resistance to the effects of microgravity and UV in particular. Several halophilic archaea (e.g., Halorubrum chaoviator) have been exposed to simulated and actual space conditions and their survival has been determined as well as the protective effects of halite shown. Finally, the intriguing potential of archaea to survive on other planets or embedded in a meteorite is postulated.

  7. On the Response of Halophilic Archaea to Space Conditions

    PubMed Central

    Leuko, Stefan; Rettberg, Petra; Pontifex, Ashleigh L.; Burns, Brendan P.

    2014-01-01

    Microorganisms are ubiquitous and can be found in almost every habitat and ecological niche on Earth. They thrive and survive in a broad spectrum of environments and adapt to rapidly changing external conditions. It is of great interest to investigate how microbes adapt to different extreme environments and with modern human space travel, we added a new extreme environment: outer space. Within the last 50 years, technology has provided tools for transporting microbial life beyond Earth’s protective shield in order to study in situ responses to selected conditions of space. This review will focus on halophilic archaea, as, due to their ability to survive in extremes, they are often considered a model group of organisms to study responses to the harsh conditions associated with space. We discuss ground-based simulations, as well as space experiments, utilizing archaea, examining responses and/or resistance to the effects of microgravity and UV in particular. Several halophilic archaea (e.g., Halorubrum chaoviator) have been exposed to simulated and actual space conditions and their survival has been determined as well as the protective effects of halite shown. Finally, the intriguing potential of archaea to survive on other planets or embedded in a meteorite is postulated. PMID:25370029

  8. Confined space emergency response: assessing employer and fire department practices.

    PubMed

    Wilson, Michael P; Madison, Heather N; Healy, Stephen B

    2012-01-01

    An emergency response plan for industrial permit-required confined space entry is essential for employee safety and is legally required. Maintaining a trained confined space rescue team, however, is costly and technically challenging. Some employers turn to public fire departments to meet their emergency response requirements. The confined space emergency response practices of employers and fire departments have not been previously assessed. We present (1) federal data on the U.S. occurrence between 1992 and 2005 of confined space fatal incidents involving toxic and/or oxygen-deficient atmospheres; (2) survey data from 21 large companies on permit-required confined space emergency response practices; (3) data on fire department arrival times; and (4) estimates by 10 senior fire officers of fire department rescue times for confined space incidents. Between 1992 and 2005, 431 confined space incidents that met the case definition claimed 530 lives, or about 0.63% of the 84,446 all-cause U.S. occupational fatal injuries that occurred during this period. Eighty-seven (20%) incidents resulted in multiple fatalities. Twelve (57%) of 21 surveyed companies reported that they relied on the fire department for permit-required confined space emergency response. Median fire department arrival times were about 5 min for engines and 7 min for technical rescue units. Fire department confined space rescue time estimates ranged from 48 to 123 min and increased to 70 and 173 min when hazardous materials were present. The study illustrates that (1) confined space incidents represent a small but continuing source of fatal occupational injuries in the United States; (2) a sizeable portion of employers may be relying on public fire departments for permit-required confined space emergency response; and (3) in the event of a life-threatening emergency, fire departments usually are not able to effect a confined space rescue in a timely manner. We propose that the appropriate role for the fire department is to support a properly trained and equipped on-site rescue team and to provide advanced life support intervention following extrication and during ambulance transportation.

  9. Space shuttle rudder/speedbrake subsystem analysis

    NASA Technical Reports Server (NTRS)

    Duke, H. G.

    1975-01-01

    The Continuous System Modeling Program (CSMP) is described with its uses, its limitations, and its application to the rudder/speedbrake (R/SB) subsystem. The space shuttle R/SB is analyzed using the CSMP. Areas of analysis emphasized include: step response, ramp response, and the delay time or deadspace observed in system response. Results are presented and discussed.

  10. 14 CFR 1212.703 - Headquarters and Field or Component Installations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Headquarters and Field or Component Installations. 1212.703 Section 1212.703 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.703 Headquarters and Field or...

  11. 14 CFR 1212.703 - Headquarters and Field or Component Installations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Headquarters and Field or Component Installations. 1212.703 Section 1212.703 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.703 Headquarters and Field or...

  12. Is It All Task-Specific? The Role of Binary Responses, Verbal Mediation, and Saliency for Eliciting Language-Space Associations

    ERIC Educational Resources Information Center

    Dudschig, Carolin; Kaup, Barbara

    2017-01-01

    Associations between language and space are of central interest for grounded models of language comprehension. Various studies show that reading words such as "bird" or "shoe" results in faster responses toward the typical location of the corresponding entity (e.g., after "bird", upward responses are faster than…

  13. Histological and Transcriptomic Analysis of Adult Japanese Medaka Sampled Onboard the International Space Station

    PubMed Central

    Murata, Yasuhiko; Yasuda, Takako; Watanabe-Asaka, Tomomi; Oda, Shoji; Mantoku, Akiko; Takeyama, Kazuhiro; Chatani, Masahiro; Kudo, Akira; Uchida, Satoko; Suzuki, Hiromi; Tanigaki, Fumiaki; Shirakawa, Masaki; Fujisawa, Koichi; Hamamoto, Yoshihiko; Terai, Shuji; Mitani, Hiroshi

    2015-01-01

    To understand how humans adapt to the space environment, many experiments can be conducted on astronauts as they work aboard the Space Shuttle or the International Space Station (ISS). We also need animal experiments that can apply to human models and help prevent or solve the health issues we face in space travel. The Japanese medaka (Oryzias latipes) is a suitable model fish for studying space adaptation as evidenced by adults of the species having mated successfully in space during 15 days of flight during the second International Microgravity Laboratory mission in 1994. The eggs laid by the fish developed normally and hatched as juveniles in space. In 2012, another space experiment (“Medaka Osteoclast”) was conducted. Six-week-old male and female Japanese medaka (Cab strain osteoblast transgenic fish) were maintained in the Aquatic Habitat system for two months in the ISS. Fish of the same strain and age were used as the ground controls. Six fish were fixed with paraformaldehyde or kept in RNA stabilization reagent (n = 4) and dissected for tissue sampling after being returned to the ground, so that several principal investigators working on the project could share samples. Histology indicated no significant changes except in the ovary. However, the RNA-seq analysis of 5345 genes from six tissues revealed highly tissue-specific space responsiveness after a two-month stay in the ISS. Similar responsiveness was observed among the brain and eye, ovary and testis, and the liver and intestine. Among these six tissues, the intestine showed the highest space response with 10 genes categorized as oxidation–reduction processes (gene ontogeny term GO:0055114), and the expression levels of choriogenin precursor genes were suppressed in the ovary. Eleven genes including klf9, klf13, odc1, hsp70 and hif3a were upregulated in more than four of the tissues examined, thus suggesting common immunoregulatory and stress responses during space adaptation. PMID:26427061

  14. Histological and Transcriptomic Analysis of Adult Japanese Medaka Sampled Onboard the International Space Station.

    PubMed

    Murata, Yasuhiko; Yasuda, Takako; Watanabe-Asaka, Tomomi; Oda, Shoji; Mantoku, Akiko; Takeyama, Kazuhiro; Chatani, Masahiro; Kudo, Akira; Uchida, Satoko; Suzuki, Hiromi; Tanigaki, Fumiaki; Shirakawa, Masaki; Fujisawa, Koichi; Hamamoto, Yoshihiko; Terai, Shuji; Mitani, Hiroshi

    2015-01-01

    To understand how humans adapt to the space environment, many experiments can be conducted on astronauts as they work aboard the Space Shuttle or the International Space Station (ISS). We also need animal experiments that can apply to human models and help prevent or solve the health issues we face in space travel. The Japanese medaka (Oryzias latipes) is a suitable model fish for studying space adaptation as evidenced by adults of the species having mated successfully in space during 15 days of flight during the second International Microgravity Laboratory mission in 1994. The eggs laid by the fish developed normally and hatched as juveniles in space. In 2012, another space experiment ("Medaka Osteoclast") was conducted. Six-week-old male and female Japanese medaka (Cab strain osteoblast transgenic fish) were maintained in the Aquatic Habitat system for two months in the ISS. Fish of the same strain and age were used as the ground controls. Six fish were fixed with paraformaldehyde or kept in RNA stabilization reagent (n = 4) and dissected for tissue sampling after being returned to the ground, so that several principal investigators working on the project could share samples. Histology indicated no significant changes except in the ovary. However, the RNA-seq analysis of 5345 genes from six tissues revealed highly tissue-specific space responsiveness after a two-month stay in the ISS. Similar responsiveness was observed among the brain and eye, ovary and testis, and the liver and intestine. Among these six tissues, the intestine showed the highest space response with 10 genes categorized as oxidation-reduction processes (gene ontogeny term GO:0055114), and the expression levels of choriogenin precursor genes were suppressed in the ovary. Eleven genes including klf9, klf13, odc1, hsp70 and hif3a were upregulated in more than four of the tissues examined, thus suggesting common immunoregulatory and stress responses during space adaptation.

  15. 14 CFR 417.21 - Financial responsibility requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....21 Section 417.21 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY General and License Terms and Conditions... responsibility requirements as required by part 440 of this chapter and as specified in a license or license...

  16. 14 CFR 417.21 - Financial responsibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....21 Section 417.21 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY General and License Terms and Conditions... responsibility requirements as required by part 440 of this chapter and as specified in a license or license...

  17. Biological and psychosocial effects of space travel: A case study

    NASA Astrophysics Data System (ADS)

    Hsia, Robert Edward Tien Ming

    This dissertation interviewed a single astronaut to explore psychosocial issues relevant to long-duration space travel and how these issues relate to the astronaut's training. It examined the psychological impact of isolation, crew interaction, and the experience of microgravity with the goal of increasing understanding of how to foster crew survivability and positive small group interactions in space (Santy, 1994). It also focused on how to develop possible treatments for crews when they transition back to Earth from the extreme environment of space missions. The astronaut's responses agreed with the literature and the predictions for long-duration space missions except the participant reported no temporary or permanent cognitive or memory deficits due to microgravity exposure. The dissertation identified five frequently endorsed themes including communication, environmental stressors, personal strengths, un-researched problems, and other. The agreement found between the literature and astronaut's responses offer a strong foundation of questions and data that needs to be further studied before conducting research in space or long-duration space missions.

  18. Dynamic expansion of alert responses to incoming painful stimuli following tool use.

    PubMed

    Rossetti, Angela; Romano, Daniele; Bolognini, Nadia; Maravita, Angelo

    2015-04-01

    Peripersonal space is the region closely surrounding our bodies. Within its boundaries, avoidance of threatening objects is crucial for surviving. Here we explored autonomic responses to painful stimuli with respect to the dynamic properties of the peripersonal space in healthy individuals. To this aim, in a series of experiments, we measured the Skin Conductance Response (SCR) to a noxious stimulus approaching and touching the hand, or stopping at different distances (far, near) from it. Results showed that the anticipatory response to an incoming threat is reduced if the stimulus targets a spatial position far away from the body, as compared to a near or bodily location. However, responses to far stimuli change if the boundaries of reachable space are extended further away by active tool use. Noteworthy, SCR is not influenced by a training consisting of a spatial attention task, without active tool use. This evidence sheds novel light on the adaptive role of peripersonal space, showing its importance for the coding of incoming threatening stimuli and its plasticity induced by contingent experience, such as tool use. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. The Race Toward Becoming Operationally Responsive in Space

    NASA Astrophysics Data System (ADS)

    Nagy, J.; Hernandez, V.; Strunce, R.

    The US Air Force Research Laboratory (AFRL) is currently supporting the joint Operationally Responsive Space (ORS) program with two aggressive research space programs. The goal of the ORS program is to improve the responsiveness of space capabilities to meet national security requirements. ORS systems aim to provide operational space capabilities as well as flexibility and responsiveness to the theater that do not exist today. ORS communication, navigation, and Intelligence, Surveillance and Reconnaissance (ISR) satellites are being designed to rapidly meet near term space needs of in-theater tactical forces by supporting contingency operations, such as increased communication bandwidth, and ISR imagery over the theater for a limited period to support air, ground, and naval force missions. This paper will discuss how AFRL/RHA is supporting the ORS effort and describe the hardware and software being developed with a particular focus on the Satellite Design Tool for plug-n-play satellites (SDT). AFRLs Space Vehicles Directorate together with the Scientific Simulation, Inc. was the first to create the Plug-and-play (PnP) satellite design for rapid construction through modular components that encompass the structural panels, as well as the guidance and health/status components. Expansion of the PnP technology is currently being led by AFRL's Human Effectiveness Directorate and Star Technologies Corp. by pushing the boundaries of mobile hardware and software technology through the development of the teams "Training and Tactical ORS Operations (TATOO) Laboratory located in Great Falls, VA. The TATOO Laboratory provides a computer-based simulation environment directed at improving Warfighters space capability responsiveness by delivering the means to create and exercise methods of in-theater tactical satellite tasking for and by the Warfighter. In an effort to further support the evolution of ORS technologies with Warfighters involvement, Star recently started coordinating the integration of the TATOO Laboratory with a satellite robotics test bed. Accessible via the TATOO Lab, the robotics test bed will be used to demonstrate and evaluate leading edge satellite technologies, such as Guidance Navigation and Control, attitude control, formation flying, and plug-and-play electronics. The test bed will consist of a Mission Control Center with wireless control and telemetry, an exceptionally flat and smooth floor area, and two robotic satellite simulators equipped with next generation plug-and-play hardware.

  20. 41 CFR 102-85.145 - When are customer agencies responsible for Rent charges?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; or (2) All other space: Either GSA's space charges for 4 months plus the cost of tenant improvements or GSA's actual costs, whichever is less. ... PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Rent Charges § 102-85.145 When are customer agencies...

  1. Inflight exercise affects stand test responses after space flight

    NASA Technical Reports Server (NTRS)

    Lee, S. M.; Moore, A. D. Jr; Fritsch-Yelle, J. M.; Greenisen, M. C.; Schneider, S. M.

    1999-01-01

    PURPOSE: The purpose of this study was to determine whether exercise performed by Space Shuttle crew members during short-duration space flights (9-16 d) affects the heart rate (HR) and blood pressure (BP) responses to standing within 2-4 h of landing. METHODS: Thirty crew members performed self-selected inflight exercise and maintained exercise logs to monitor their exercise intensity and duration. Two subjects participated in this investigation during two different flights. A 10-min stand test, preceded by at least 6 min of quiet supine rest, was completed 10-15 d before launch (PRE) and within 4 h of landing (POST). Based upon their inflight exercise records, subjects were grouped as either high (HIex: > or = 3 times/week, HR > or = 70% HRmax, > or = 20 min/session, N = 11), medium (MEDex: > or = 3 times/week, HR < 70% HRmax, > or = 20 min/session, N = 10), or low (LOex: < or = 3 times/week, HR and duration variable, N = 11) exercisers. HR and BP responses to standing were compared between groups (ANOVA, P < or = 0.05). RESULTS: There were no PRE differences between the groups in supine or standing HR and BP. Although POST supine HR was similar to PRE, all groups had an increased standing HR compared with PRE. The increase in HR upon standing was significantly greater after flight in the LOex group (36 +/- 5 bpm) compared with HIex or MEDex groups (25 +/- 1 bpm; 22 +/- 2 bpm). Similarly, the decrease in pulse pressure (PP) from supine to standing was unchanged after space flight in the MEDex and HIex groups but was significantly greater in the LOex group (PRE: -9 +/- 3; POST: -19 +/- 4 mm Hg). CONCLUSIONS: Thus, moderate to high levels of inflight exercise attenuated HR and PP responses to standing after space flight.

  2. Immune suppression of human lymphoid tissues and cells in rotating suspension culture and onboard the International Space Station

    PubMed Central

    Fitzgerald, Wendy; Chen, Silvia; Walz, Carl; Zimmerberg, Joshua; Margolis, Leonid

    2013-01-01

    The immune responses of human lymphoid tissue explants or cells isolated from this tissue were studied quantitatively under normal gravity and microgravity. Microgravity was either modeled by solid body suspension in a rotating, oxygenated culture vessel or was actually achieved on the International Space Station (ISS). Our experiments demonstrate that tissues or cells challenged by recall antigen or by polyclonal activator in modeled microgravity lose all their ability to produce antibodies and cytokines and to increase their metabolic activity. In contrast, if the cells were challenged before being exposed to modeled microgravity suspension culture, they maintained their responses. Similarly, in microgravity in the ISS, lymphoid cells did not respond to antigenic or polyclonal challenge, whereas cells challenged prior to the space flight maintained their antibody and cytokine responses in space. Thus, immune activation of cells of lymphoid tissue is severely blunted both in modeled and true microgravity. This suggests that suspension culture via solid body rotation is sufficient to induce the changes in cellular physiology seen in true microgravity. This phenomenon may reflect immune dysfunction observed in astronauts during space flights. If so, the ex vivo system described above can be used to understand cellular and molecular mechanisms of this dysfunction. PMID:19609626

  3. Short-Term Modulation of the Ventilatory Response to Exercise is Preserved in Obstructive Sleep Apnea

    PubMed Central

    Bernhardt, Vipa; Mitchell, Gordon S.; Lee, Won Y.; Babb, Tony G.

    2016-01-01

    Background The ventilatory response to exercise can be transiently adjusted in response to environmentally (e.g., breathing apparatus) or physiologically altered conditions (e.g., respiratory disease), maintaining constant relative arterial PCO2 regulation from rest to exercise (Mitchell and Babb, 2006); this augmentation is called short-term modulation (STM) of the exercise ventilatory response. Obesity and/or obstructive sleep apnea could affect the exercise ventilatory response and the capacity for STM due to chronically increased mechanical and/or ventilatory loads on the respiratory system, and/or recurrent (chronic) intermittent hypoxia experienced during sleep. We hypothesized that: 1) the exercise ventilatory response is augmented in obese OSA patients compared with obese non-OSA adults, and 2) the capacity for STM with added dead space is diminished in obese OSA patients. Methods Nine obese adults with OSA (age: 39 ± 6 yr, BMI: 40 ± 5 kg/m2, AHI: 25 ± 24 events/hr [range 6–73], mean ± SD) and 8 obese adults without OSA (age: 38 ± 10 yr, BMI: 37 ± 6 kg/m2, AHI: 1 ± 2) completed three, 20-min bouts of constant-load submaximal cycling exercise (8 min rest, 6 min at 10 and 30 W) with or without added external dead space (200 or 400 ml; 20 min rest between bouts). Steady-state measurements were made of ventilation (V̇E), oxygen consumption (V̇O2), carbon dioxide production (V̇CO2), and end-tidal PCO2 (PETCO2). The exercise ventilatory response was defined as the slope of the V̇E-V̇CO2 relationship (ΔV̇E/ΔV̇CO2). Results In control (i.e. no added dead space), the exercise ventilatory response was not significantly different between non-OSA and OSA groups (ΔV̇E/ΔV̇CO2 slope: 30.5 ± 4.2 vs 30.5 ± 3.8, p > 0.05); PETCO2 regulation from rest to exercise did not differ between groups (p > 0.05). In trials with added external dead space, ΔV̇E/ΔV̇CO2 increased with increased dead space (p < 0.05) and the PETCO2 change from rest to exercise remained small (<2 mmHg) in both groups, demonstrating STM. There were no significant differences between groups. Conclusions Contrary to our hypotheses: 1) the exercise ventilatory response is not increased in obese OSA patients compared with obese non-OSA adults, and 2) the capacity for STM with added dead space is preserved in obese OSA and non-OSA adults. PMID:27840272

  4. Differential effects of massed and spaced training on place and response learning: A memory systems perspective.

    PubMed

    Wingard, Jeffrey C; Goodman, Jarid; Leong, Kah-Chung; Packard, Mark G

    2015-09-01

    Studies employing brain lesion or intracerebral drug infusions in rats have demonstrated a double dissociation between the roles of the hippocampus and dorsolateral striatum in place and response learning. The hippocampus mediates a rapid cognitive learning process underlying place learning, whereas the dorsolateral striatum mediates a relatively slower learning process in which stimulus-response habits underlying response learning are acquired in an incremental fashion. One potential implication of these findings is that hippocampus-dependent learning may benefit from a relative massing of training trials, whereas dorsal striatum-dependent learning may benefit from a relative distribution of training trials. In order to examine this hypothesis, the present study compared the effects of massed (30s inter-trial interval; ITI) or spaced (30min ITI) training on acquisition of a hippocampus-dependent place learning task, and a dorsolateral striatum-dependent response task in a plus-maze. In the place task rats swam from varying start points (N or S) to a hidden escape platform located in a consistent spatial location (W). In the response task rats swam from varying start points (N or S) to a hidden escape platform located in the maze arm consistent with a body-turn response (left). In the place task, rats trained with the massed trial schedule acquired the task quicker than rats trained with the spaced trial schedule. In the response task, rats trained with the spaced trial schedule acquired the task quicker than rats trained with the massed trial schedule. The double dissociation observed suggests that the reinforcement parameters most conducive to effective learning in hippocampus-dependent and dorsolateral striatum-dependent learning may have differential temporal characteristics. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Symposium Conclusion: Women's cardiovascular health after bed rest or space flight

    NASA Astrophysics Data System (ADS)

    Hughson, Richard L.; Arbeille, Phillipe; Shoemaker, Kevin; Edgell, Heather

    The Canadian Space Agency has recently funded research on two long-duration missions to study cardiovascular deconditioning associated with bed rest or space flight. The first, Women's International Space simulation for Exploration (WISE-2005) examined the responses during a 60-day head down bed rest (HDBR) of 24 women with or without a countermeasure that consisted of supine treadmill running within a lower body negative pressure (LBNP) device followed by 10-minutes resting LBNP and on different days high intensity resistance exercise on a flywheel device. The second study, Cardiovascular and cerebrovascular Control on return from the International Space Station (CCISS) is currently underway with two male astronauts tested and the first woman anticipated later this year. Women have been previously identified as being more susceptible to orthostatic intolerance than men after both bed rest and space flight studies. Thus, in the WISE-2005 study we examined responses of the cardiovascular system after HDBR in women and compared these to previously published data from men. We found that after HDBR women have a greater increase in heart rate with infusion of the drug isoproterenol and this was consistent with observations in men. However, during drug infusion the women had a reduction in leg vascular resistance while men had an increase. The exercise countermeasure group had preserved heart rate and leg vascular resistance responses to drug infusion. The ability to vasoconstrict the legs and splanchnic region is critical to maintenance of upright posture after HDBR and space flight. In the WISE-2005 study, subjects who were able to constrict the legs and/or splanchnic region after HDBR were much less likely to have a marked drop in blood pressure before the end of 10-minutes upright tilt, and subjects who performed the countermeasure were more likely to be in this group of tilt test finishers. These data provide new insight into mechanisms that might be responsible for fainting after bed rest or space flight, and they can be used to understand why specific populations such as the elderly might be more likely to faint during life on Earth. Supported by Canadian Space Agency.

  6. On the apparent insignificance of the randomness of flexible joints on large space truss dynamics

    NASA Technical Reports Server (NTRS)

    Koch, R. M.; Klosner, J. M.

    1993-01-01

    Deployable periodic large space structures have been shown to exhibit high dynamic sensitivity to period-breaking imperfections and uncertainties. These can be brought on by manufacturing or assembly errors, structural imperfections, as well as nonlinear and/or nonconservative joint behavior. In addition, the necessity of precise pointing and position capability can require the consideration of these usually negligible and unknown parametric uncertainties and their effect on the overall dynamic response of large space structures. This work describes the use of a new design approach for the global dynamic solution of beam-like periodic space structures possessing parametric uncertainties. Specifically, the effect of random flexible joints on the free vibrations of simply-supported periodic large space trusses is considered. The formulation is a hybrid approach in terms of an extended Timoshenko beam continuum model, Monte Carlo simulation scheme, and first-order perturbation methods. The mean and mean-square response statistics for a variety of free random vibration problems are derived for various input random joint stiffness probability distributions. The results of this effort show that, although joint flexibility has a substantial effect on the modal dynamic response of periodic large space trusses, the effect of any reasonable uncertainty or randomness associated with these joint flexibilities is insignificant.

  7. Request and Requirements Development Process for Operationally Responsive Space Capabilities

    DTIC Science & Technology

    2013-03-01

    future responsive space rapid acquisition urgent need is the Space Enabled Effects for Military Engagement ( SeeMe ) program. The SeeMe concept is to...developmental time the SeeMe satellites would leverage commercial off the shelf components.39 The ORS office, working with DARPA and the commercial vender would...coordinate deployment of a SeeMe capability. It is important to note, determining the acquisition employment path focuses on availability of a

  8. 76 FR 26620 - A National Broadband Plan for Our Future

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... communications space on utility poles. For wireless attachments above the communications space, we adopt a...-authorized by the utilities to complete survey and make-ready work in the communications space, subject to a... and wireless attachments either in or above the communications space. This required response is...

  9. Exploring the parahippocampal cortex response to high and low spatial frequency spaces.

    PubMed

    Zeidman, Peter; Mullally, Sinéad L; Schwarzkopf, Dietrich Samuel; Maguire, Eleanor A

    2012-05-30

    The posterior parahippocampal cortex (PHC) supports a range of cognitive functions, in particular scene processing. However, it has recently been suggested that PHC engagement during functional MRI simply reflects the representation of three-dimensional local space. If so, PHC should respond to space in the absence of scenes, geometric layout, objects or contextual associations. It has also been reported that PHC activation may be influenced by low-level visual properties of stimuli such as spatial frequency. Here, we tested whether PHC was responsive to the mere sense of space in highly simplified stimuli, and whether this was affected by their spatial frequency distribution. Participants were scanned using functional MRI while viewing depictions of simple three-dimensional space, and matched control stimuli that did not depict a space. Half the stimuli were low-pass filtered to ascertain the impact of spatial frequency. We observed a significant interaction between space and spatial frequency in bilateral PHC. Specifically, stimuli depicting space (more than nonspatial stimuli) engaged the right PHC when they featured high spatial frequencies. In contrast, the interaction in the left PHC did not show a preferential response to space. We conclude that a simple depiction of three-dimensional space that is devoid of objects, scene layouts or contextual associations is sufficient to robustly engage the right PHC, at least when high spatial frequencies are present. We suggest that coding for the presence of space may be a core function of PHC, and could explain its engagement in a range of tasks, including scene processing, where space is always present.

  10. Physiological Response to Facial Expressions in Peripersonal Space Determines Interpersonal Distance in a Social Interaction Context.

    PubMed

    Cartaud, Alice; Ruggiero, Gennaro; Ott, Laurent; Iachini, Tina; Coello, Yann

    2018-01-01

    Accurate control of interpersonal distances in social contexts is an important determinant of effective social interactions. Although comfortable interpersonal distance seems to be dependent on social factors such as the gender, age and activity of the confederates, it also seems to be modulated by the way we represent our peripersonal-action space. To test this hypothesis, the present study investigated the relation between the emotional responses registered through electrodermal activity (EDA) triggered by human-like point-light displays (PLDs) carrying different facial expressions (neutral, angry, happy) when located in the participants peripersonal or extrapersonal space, and the comfort distance with the same PLDs when approaching and crossing the participants fronto-parallel axis on the right or left side. The results show an increase of the phasic EDA for PLDs with angry facial expressions located in the peripersonal space (reachability judgment task), in comparison to the same PLDs located in the extrapersonal space, which was not observed for PLDs with neutral or happy facial expressions. The results also show an increase of the comfort distance for PLDs approaching the participants with an angry facial expression (interpersonal comfort distance judgment task), in comparison to PLDs with happy and neutral ones, which was related to the increase of the physiological response. Overall, the findings indicate that comfort social space can be predicted from the emotional reaction triggered by a confederate when located within the observer's peripersonal space. This suggests that peripersonal-action space and interpersonal-social space are similarly sensitive to the emotional valence of the confederate, which could reflect a common adaptive mechanism in specifying theses spaces to subtend interactions with both the physical and social environment, but also to ensure body protection from potential threats.

  11. Stomatal responses to flooding of the intercellular air spaces suggest a vapor-phase signal between the mesophyll and the guard cells.

    PubMed

    Sibbernsen, Erik; Mott, Keith A

    2010-07-01

    Flooding the intercellular air spaces of leaves with water was shown to cause rapid closure of stomata in Tradescantia pallida, Lactuca serriola, Helianthus annuus, and Oenothera caespitosa. The response occurred when water was injected into the intercellular spaces, vacuum infiltrated into the intercellular spaces, or forced into the intercellular spaces by pressurizing the xylem. Injecting 50 mm KCl or silicone oil into the intercellular spaces also caused stomata to close, but the response was slower than with distilled water. Epidermis-mesophyll grafts for T. pallida were created by placing the epidermis of one leaf onto the exposed mesophyll of another leaf. Stomata in these grafts opened under light but closed rapidly when water was allowed to wick between epidermis and the mesophyll. When epidermis-mesophyll grafts were constructed with a thin hydrophobic filter between the mesophyll and epidermis stomata responded normally to light and CO(2). These data, when taken together, suggest that the effect of water on stomata is caused partly by dilution of K(+) in the guard cell and partly by the existence of a vapor-phase signal that originates in the mesophyll and causes stomata to open in the light.

  12. Mouse infection models for space flight immunology

    NASA Technical Reports Server (NTRS)

    Chapes, Stephen Keith; Ganta, Roman Reddy; Chapers, S. K. (Principal Investigator)

    2005-01-01

    Several immunological processes can be affected by space flight. However, there is little evidence to suggest that flight-induced immunological deficits lead to illness. Therefore, one of our goals has been to define models to examine host resistance during space flight. Our working hypothesis is that space flight crews will come from a heterogeneous population; the immune response gene make-up will be quite varied. It is unknown how much the immune response gene variation contributes to the potential threat from infectious organisms, allergic responses or other long term health problems (e.g. cancer). This article details recent efforts of the Kansas State University gravitational immunology group to assess how population heterogeneity impacts host health, either in laboratory experimental situations and/or using the skeletal unloading model of space-flight stress. This paper details our use of several mouse strains with several different genotypes. In particular, mice with varying MHCII allotypes and mice on the C57BL background with different genetic defects have been particularly useful tools with which to study infections by Staphylococcus aureus, Salmonella typhimurium, Pasteurella pneumotropica and Ehrlichia chaffeensis. We propose that some of these experimental challenge models will be useful to assess the effects of space flight on host resistance to infection.

  13. Transcriptomic responses of germinating Bacillus subtilis spores exposed to 1.5 years of space and simulated martian conditions on the EXPOSE-E experiment PROTECT.

    PubMed

    Nicholson, Wayne L; Moeller, Ralf; Horneck, Gerda

    2012-05-01

    Because of their ubiquity and resistance to spacecraft decontamination, bacterial spores are considered likely potential forward contaminants on robotic missions to Mars. Thus, it is important to understand their global responses to long-term exposure to space or martian environments. As part of the PROTECT experiment, spores of B. subtilis 168 were exposed to real space conditions and to simulated martian conditions for 559 days in low-Earth orbit mounted on the EXPOSE-E exposure platform outside the European Columbus module on the International Space Station. Upon return, spores were germinated, total RNA extracted, fluorescently labeled, and used to probe a custom Bacillus subtilis microarray to identify genes preferentially activated or repressed relative to ground control spores. Increased transcript levels were detected for a number of stress-related regulons responding to DNA damage (SOS response, SPβ prophage induction), protein damage (CtsR/Clp system), oxidative stress (PerR regulon), and cell envelope stress (SigV regulon). Spores exposed to space demonstrated a much broader and more severe stress response than spores exposed to simulated martian conditions. The results are discussed in the context of planetary protection for a hypothetical journey of potential forward contaminant spores from Earth to Mars and their subsequent residence on Mars.

  14. Space Based Intelligence, Surveillance, and Reconnaissance Contribution to Global Strike in 2035

    DTIC Science & Technology

    2012-02-15

    include using high altitude air platforms and airships as a short-term solution, and small satellites with an Operationally Responsive Space (ORS) launch...irreversible threats, along with a worst case scenario. Section IV provides greater detail of the high altitude air platform, airship , and commercial space...Resultantly, the U.S. could use high altitude air platforms, airships , and cyber to complement its space systems in case of denial, degradation, or

  15. Logistics Operations Management Center: Maintenance Support Baseline (LOMC-MSB)

    NASA Technical Reports Server (NTRS)

    Kurrus, R.; Stump, F.

    1995-01-01

    The Logistics Operations Management Center Maintenance Support Baseline is defined. A historical record of systems, applied to and deleted from, designs in support of future management and/or technical analysis is provided. All Flight elements, Ground Support Equipment, Facility Systems and Equipment and Test Support Equipment for which LOMC has responsibilities at Kennedy Space Center and other locations are listed. International Space Station Alpha Program documentation is supplemented. The responsibility of the Space Station Launch Site Support Office is established.

  16. Ionospheric Response to Extremes in the Space Environment: Establishing Benchmarks for the Space Weather Action Plan.

    NASA Astrophysics Data System (ADS)

    Viereck, R. A.; Azeem, S. I.

    2017-12-01

    One of the goals of the National Space Weather Action Plan is to establish extreme event benchmarks. These benchmarks are estimates of environmental parameters that impact technologies and systems during extreme space weather events. Quantitative assessment of anticipated conditions during these extreme space weather event will enable operators and users of affected technologies to develop plans for mitigating space weather risks and improve preparedness. The ionosphere is one of the most important regions of space because so many applications either depend on ionospheric space weather for their operation (HF communication, over-the-horizon radars), or can be deleteriously affected by ionospheric conditions (e.g. GNSS navigation and timing, UHF satellite communications, synthetic aperture radar, HF communications). Since the processes that influence the ionosphere vary over time scales from seconds to years, it continues to be a challenge to adequately predict its behavior in many circumstances. Estimates with large uncertainties, in excess of 100%, may result in operators of impacted technologies over or under preparing for such events. The goal of the next phase of the benchmarking activity is to reduce these uncertainties. In this presentation, we will focus on the sources of uncertainty in the ionospheric response to extreme geomagnetic storms. We will then discuss various research efforts required to better understand the underlying processes of ionospheric variability and how the uncertainties in ionospheric response to extreme space weather could be reduced and the estimates improved.

  17. Impulse Response Measurements Over Space-Earth Paths Using the GPS Coarse/Acquisition Codes

    NASA Technical Reports Server (NTRS)

    Lemmon, J. J.; Papazian, P. B.

    1995-01-01

    The impulse responses of radio transmission channels over space-earth paths were measured using the course/acquisition code signals from the Global Positioning System of satellites. The data acquisition system and signal processing techniques used to develop the impulse responses are described. Examples of impulse response measurements are presented. The results indicate that this measurement approach enables detection of multipath signals that are 20 dB or more below the power of the direct arrival. Channel characteristics that could be investigated with additional measurements and analyses are discussed.

  18. Mapping Children--Mapping Space.

    ERIC Educational Resources Information Center

    Pick, Herbert L., Jr.

    Research is underway concerning the way the perception, conception, and representation of spatial layout develops. Three concepts are important here--space itself, frame of reference, and cognitive map. Cognitive map refers to a form of representation of the behavioral space, not paired associate or serial response learning. Other criteria…

  19. Muscle Research and Human Space Exploration: Current Progress and Future Challenges

    NASA Technical Reports Server (NTRS)

    Feedback, Daniel L.

    2004-01-01

    Since the beginning of human space flight, there has been serious concern over the exposure of human crewmembers to the microgravity of space due to the systemic effects on terrestrially-evolved creatures that are adapted to Earth gravity. Humans in the microgravity environment of space, within our currently developed space vehicles, are exposed to various periods of skeletal muscle unloading (unweighting). Unloading of skeletal muscle both on Earth and during spaceflight results in remodeling of muscle (atrophic response) as an adaptation to the reduced loads placed upon it. As a result, there are decrements in skeletal muscle strength, fatigue resistance, motor performance, and connective tissue integrity. This normal adaptive response to the microgravity environment is for the most part of little consequence within the space vehicle per se but may become a liability resulting in an increased risk of crewmember physical failure during extravehicular activities or abrupt transitions to environments of increased gravity (such as return to Earth or landing on another planetary body).

  20. Dynamic response of a poroelastic half-space to accelerating or decelerating trains

    NASA Astrophysics Data System (ADS)

    Cao, Zhigang; Boström, Anders

    2013-05-01

    The dynamic response of a fully saturated poroelastic half-space due to accelerating or decelerating trains is investigated by a semi-analytical method. The ground is modeled as a saturated poroelastic half-space and Biot's theory is applied to characterize the soil medium, taking the coupling effects between the soil skeleton and the pore fluid into account. A detailed track system is considered incorporating rails, sleepers and embankment, which are modeled as Euler-Bernoulli beams, an anisotropic Kirchhoff plate, and an elastic layer, respectively. The acceleration or deceleration of the train is simulated by properly choosing the time history of the train speed using Fourier transforms combined with Fresnel integrals in the transformed domain. The time domain results are obtained by the fast Fourier transform (FFT). It is found that the deceleration of moving trains can cause a significant increase to the ground vibrations as well as the excess pore water pressure responses at the train speed 200 km/h. Furthermore, the single-phase elastic soil model would underestimate the vertical displacement responses caused by both the accelerating and decelerating trains at the speed 200 km/h.

  1. KENNEDY SPACE CENTER, FLA. - Dignitaries, invited guests, space center employees, and the media gather for a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

    NASA Image and Video Library

    2003-11-19

    KENNEDY SPACE CENTER, FLA. - Dignitaries, invited guests, space center employees, and the media gather for a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  2. KENNEDY SPACE CENTER, FLA. - Capt. Winston Scott, executive director of the Florida Space Authority, speaks at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

    NASA Image and Video Library

    2003-11-19

    KENNEDY SPACE CENTER, FLA. - Capt. Winston Scott, executive director of the Florida Space Authority, speaks at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  3. Probabilistic Structural Analysis Methods (PSAM) for Select Space Propulsion System Components

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Probabilistic Structural Analysis Methods (PSAM) are described for the probabilistic structural analysis of engine components for current and future space propulsion systems. Components for these systems are subjected to stochastic thermomechanical launch loads. Uncertainties or randomness also occurs in material properties, structural geometry, and boundary conditions. Material property stochasticity, such as in modulus of elasticity or yield strength, exists in every structure and is a consequence of variations in material composition and manufacturing processes. Procedures are outlined for computing the probabilistic structural response or reliability of the structural components. The response variables include static or dynamic deflections, strains, and stresses at one or several locations, natural frequencies, fatigue or creep life, etc. Sample cases illustrates how the PSAM methods and codes simulate input uncertainties and compute probabilistic response or reliability using a finite element model with probabilistic methods.

  4. Complementary Hand Responses Occur in Both Peri- and Extrapersonal Space.

    PubMed

    Faber, Tim W; van Elk, Michiel; Jonas, Kai J

    2016-01-01

    Human beings have a strong tendency to imitate. Evidence from motor priming paradigms suggests that people automatically tend to imitate observed actions such as hand gestures by performing mirror-congruent movements (e.g., lifting one's right finger upon observing a left finger movement; from a mirror perspective). Many observed actions however, do not require mirror-congruent responses but afford complementary (fitting) responses instead (e.g., handing over a cup; shaking hands). Crucially, whereas mirror-congruent responses don't require physical interaction with another person, complementary actions often do. Given that most experiments studying motor priming have used stimuli devoid of contextual information, this space or interaction-dependency of complementary responses has not yet been assessed. To address this issue, we let participants perform a task in which they had to mirror or complement a hand gesture (fist or open hand) performed by an actor depicted either within or outside of reach. In three studies, we observed faster reaction times and less response errors for complementary relative to mirrored hand movements in response to open hand gestures (i.e., 'hand-shaking') irrespective of the perceived interpersonal distance of the actor. This complementary effect could not be accounted for by a low-level spatial cueing effect. These results demonstrate that humans have a strong and automatic tendency to respond by performing complementary actions. In addition, our findings underline the limitations of manipulations of space in modulating effects of motor priming and the perception of affordances.

  5. Stomatal Responses to Flooding of the Intercellular Air Spaces Suggest a Vapor-Phase Signal Between the Mesophyll and the Guard Cells1[OA

    PubMed Central

    Sibbernsen, Erik; Mott, Keith A.

    2010-01-01

    Flooding the intercellular air spaces of leaves with water was shown to cause rapid closure of stomata in Tradescantia pallida, Lactuca serriola, Helianthus annuus, and Oenothera caespitosa. The response occurred when water was injected into the intercellular spaces, vacuum infiltrated into the intercellular spaces, or forced into the intercellular spaces by pressurizing the xylem. Injecting 50 mm KCl or silicone oil into the intercellular spaces also caused stomata to close, but the response was slower than with distilled water. Epidermis-mesophyll grafts for T. pallida were created by placing the epidermis of one leaf onto the exposed mesophyll of another leaf. Stomata in these grafts opened under light but closed rapidly when water was allowed to wick between epidermis and the mesophyll. When epidermis-mesophyll grafts were constructed with a thin hydrophobic filter between the mesophyll and epidermis stomata responded normally to light and CO2. These data, when taken together, suggest that the effect of water on stomata is caused partly by dilution of K+ in the guard cell and partly by the existence of a vapor-phase signal that originates in the mesophyll and causes stomata to open in the light. PMID:20472750

  6. Temazepam, But Not Zolpidem, Causes Orthostatic Hypotension in Astronauts After Spaceflight

    NASA Technical Reports Server (NTRS)

    Shi, Shang-Jin; Garcia, Kathleen M.; Meck, Janice V.

    2002-01-01

    Many astronauts do not sleep well due to the difficult environment in space. Hypnotics such as temazepam or zolpidem are often taken while in space and/or the night prior to returning to Earth. Until now, no data have illustrated the effect of these sleeping medications on postflight hemodynamic responses. The purpose of this study was to determine if the use of different hypnotics during flight has any effect on cardiovascular responses to standing in astronauts upon returning to Earth's gravity.

  7. Simulating Vibrations in a Complex Loaded Structure

    NASA Technical Reports Server (NTRS)

    Cao, Tim T.

    2005-01-01

    The Dynamic Response Computation (DIRECT) computer program simulates vibrations induced in a complex structure by applied dynamic loads. Developed to enable rapid analysis of launch- and landing- induced vibrations and stresses in a space shuttle, DIRECT also can be used to analyze dynamic responses of other structures - for example, the response of a building to an earthquake, or the response of an oil-drilling platform and attached tanks to large ocean waves. For a space-shuttle simulation, the required input to DIRECT includes mathematical models of the space shuttle and its payloads, and a set of forcing functions that simulates launch and landing loads. DIRECT can accommodate multiple levels of payload attachment and substructure as well as nonlinear dynamic responses of structural interfaces. DIRECT combines the shuttle and payload models into a single structural model, to which the forcing functions are then applied. The resulting equations of motion are reduced to an optimum set and decoupled into a unique format for simulating dynamics. During the simulation, maximum vibrations, loads, and stresses are monitored and recorded for subsequent analysis to identify structural deficiencies in the shuttle and/or payloads.

  8. Bioavailability and Pharmacodynamics of Promethazine on Long Duration Missions to the International Space Station

    NASA Technical Reports Server (NTRS)

    Putcha, Lakshmi; Boyd, Jason L.; Cintron, Nitza; Berens, Kurt L.

    2004-01-01

    Space motion sickness (SMS) is often treated in space with promethazine (PMZ). Common side effects of PMZ administration (50 mg intramuscular) on the ground are drowsiness and impaired cognitive performance. Anecdotal reports indicate that these effects are absent or less pronounced in space. This suggests that the availability of PMZ to the body (bioavailability) and/or the response of the body to PMZ (pharmacodynamics) may change during space flight. Opportunities for clinical research in space are limited. The study described here is our response to a NASA Research Announcement for proposals for flight-based research needed to improve, or answer specific questions about, diagnosis and therapy during space flight, and post-flight rehabilitation. We propose here to evaluate noninvasive methods for determining the bioavailability and pharmacodynamics of PMZ. The specific objectives of the proposed research are to 1) compare pharmacokinetic and pharmacodynamic parameters of PMZ, estimated from saliva and plasma levels after administration of PMZ, 2) estimate the relative bioavailability of the three dosage forms of PMZ that are often administered to control motion sickness symptoms in space, and 3) establish the dose-response relationship of PMZ. We will estimate the bioavailability of an intramuscular injection (IM), oral tablet, and rectal suppository of PMZ in noma1 subjects during ambulatory and antiorthostatic bed rest (ABR) conditions using novel stable isotope techniques. We will compare and contrast the bioavailability of PMZ during normal and microgravity conditions to examine changes in drug absorption and bioavailability during microgravit. Results of this study will validate methods for an approved in-flight investigation with this medication awaiting an opportunity for manifestation..

  9. Fathers Online: Learning About Fatherhood Through the Internet

    PubMed Central

    StGeorge, Jennifer M.; Fletcher, Richard J.

    2011-01-01

    In the transition to fatherhood, men face numerous challenges. Opportunities to learn new practices and gain support are limited, although the provisions of father-specific spaces such as fathers’ antenatal classes or “responsible fathering” programs are important advances. This article explores how men use the social space of a father-specific Internet chat room to learn about fathering. Messages to an Australian-hosted, father-specific chat room (for fathers of infants or young children) were examined, and three overlapping themes illustrated men’s perceptions of their transition to fatherhood. The themes concerned recognition of and response to a lack of social space, services, and support for new fathers. The implications for fathers’ perinatal education are discussed. PMID:22654464

  10. NASA Office of Aeronautical and Space Technology Summer Workshop. Volume 6: Structures and dynamics panel

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Structural requirements for future space missions were defined in relation to technology needs and payloads. Specific areas examined include: large area space structures (antennas, solar array structures, and platforms); a long, slender structure or boom used to support large objects from the shuttle or hold two bodies apart in space; and advanced composite structures for cost effective weight reductions. Other topics discussed include: minimum gage concepts, high temperature components, load and response determination and control, and reliability and life prediction.

  11. Office of the Associate Administrator for Commercial Space Transportation: Insurance Determinations Requirements As of July 22, 1997

    DOT National Transportation Integrated Search

    1997-07-22

    The Commercial Space Launch Act requires that all commercial licensees : demonstrate financial responsibility to compensate for the maximum probable : loss (MPL) from claims by a third party for death, bodily injury, or property : damage or loss resu...

  12. KENNEDY SPACE CENTER, FLA. - Frank T. Brogan, president of the Florida Atlantic University, speaks at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

    NASA Image and Video Library

    2003-11-19

    KENNEDY SPACE CENTER, FLA. - Frank T. Brogan, president of the Florida Atlantic University, speaks at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  13. Pharmacotherapeutic Aspects of Space Medicine

    NASA Technical Reports Server (NTRS)

    Putcha, Lakshmi

    2004-01-01

    Medications are used for a wide variety of indications during space flight. For example, astronauts have taken drugs in flight to ameliorate or prevent symptoms of space motion sickness, headache, sleeplessness, backache, nasal congestion, and constipation. Russian cosmonauts reportedly take medications to prevent metabolic disturbances of the myocardium and intestinal flora, and to optimize their work capacity. Although the discomfort associated with some acute responses to microgravity (e.g., space motion sickness) is expected to diminish with length of time in flight, other responses that have delayed onset (e.g., maintaining nutritional status, bone and muscle strength, and perhaps immune response) may affect health and quality of life during longer missions. Therefore, as the duration of space flights increases, the need for treatment with medications is expected to increase accordingly. Medications carried on Space Shuttle missions have varied somewhat from flight to flight, depending on the individual needs of the crewmembers. Medications use during Shuttle flights seems to be more prevalent than during earlier programs, perhaps because drugs are provided in easy-to-use forms. In fact, nearly all medications taken to date have been ingested orally in tablet form. However, given that the oral route may not be ideal for those suffering motion-sickness symptoms, intramuscular and intranasal preparations are being tested. For example, intramuscular administration of promethazine hydrochloride (Phenergan(Registered TradeMark)) has been reported to be more effective in alleviating motion-sickness symptoms. The difficulties involved in conducting definitive studies of drug efficacy during U.S. space flights have been compounded by the absence of a systematic approach to determining which drugs were taken by whom and under what circumstances. The use of some drugs in space has been less efficacious than expected. The onset, intensity, and duration of the response produced by any drug depend upon rates of absorption, distribution, metabolism, and elimination of the drug; space flight-induced changes in blood flow and the function of the gastrointestinal (GI) tract, liver, or kidneys may alter these processes. Another important aspect of clinical efficacy of medications in space is the stability of pharmaceuticals. As the U.S. space program is moving toward extended Space Shuttle flights and beyond, to space station missions and planetary explorations, understanding how space flight affects organ systems and clinical pharmacology is necessary to optimize pharmacotherapeutics in space and ensure adequate safety and health of crewmembers.

  14. Development of a GCR Event-based Risk Model

    NASA Technical Reports Server (NTRS)

    Cucinotta, Francis A.; Ponomarev, Artem L.; Plante, Ianik; Carra, Claudio; Kim, Myung-Hee

    2009-01-01

    A goal at NASA is to develop event-based systems biology models of space radiation risks that will replace the current dose-based empirical models. Complex and varied biochemical signaling processes transmit the initial DNA and oxidative damage from space radiation into cellular and tissue responses. Mis-repaired damage or aberrant signals can lead to genomic instability, persistent oxidative stress or inflammation, which are causative of cancer and CNS risks. Protective signaling through adaptive responses or cell repopulation is also possible. We are developing a computational simulation approach to galactic cosmic ray (GCR) effects that is based on biological events rather than average quantities such as dose, fluence, or dose equivalent. The goal of the GCR Event-based Risk Model (GERMcode) is to provide a simulation tool to describe and integrate physical and biological events into stochastic models of space radiation risks. We used the quantum multiple scattering model of heavy ion fragmentation (QMSFRG) and well known energy loss processes to develop a stochastic Monte-Carlo based model of GCR transport in spacecraft shielding and tissue. We validated the accuracy of the model by comparing to physical data from the NASA Space Radiation Laboratory (NSRL). Our simulation approach allows us to time-tag each GCR proton or heavy ion interaction in tissue including correlated secondary ions often of high multiplicity. Conventional space radiation risk assessment employs average quantities, and assumes linearity and additivity of responses over the complete range of GCR charge and energies. To investigate possible deviations from these assumptions, we studied several biological response pathway models of varying induction and relaxation times including the ATM, TGF -Smad, and WNT signaling pathways. We then considered small volumes of interacting cells and the time-dependent biophysical events that the GCR would produce within these tissue volumes to estimate how GCR event rates mapped to biological signaling induction and relaxation times. We considered several hypotheses related to signaling and cancer risk, and then performed simulations for conditions where aberrant or adaptive signaling would occur on long-duration space mission. Our results do not support the conventional assumptions of dose, linearity and additivity. A discussion on how event-based systems biology models, which focus on biological signaling as the mechanism to propagate damage or adaptation, can be further developed for cancer and CNS space radiation risk projections is given.

  15. Children's Responses to Line Spacing in Early Reading Books or "Holes to Tell Which Line You're On"

    ERIC Educational Resources Information Center

    Reynolds, Linda; Walker, Sue; Duncan, Alison

    2006-01-01

    This paper describes a study designed to find out whether children's reading would be affected by line spacing that is wider or narrower than the commonly used default values. The realistic, high quality test material was set using a range of four different line spacing values, and twenty-four children in Years 1 and 2 (between five and seven…

  16. Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space

    PubMed Central

    Ertl, Andrew C; Diedrich, André; Biaggioni, Italo; Levine, Benjamin D; Robertson, Rose Marie; Cox, James F; Zuckerman, Julie H; Pawelczyk, James A; Ray, Chester A; Buckey, Jay C; Lane, Lynda D; Shiavi, Richard; Gaffney, F Andrew; Costa, Fernando; Holt, Carol; Blomqvist, C Gunnar; Eckberg, Dwain L; Baisch, Friedhelm J; Robertson, David

    2002-01-01

    Astronauts returning from space have reduced red blood cell masses, hypovolaemia and orthostatic intolerance, marked by greater cardio–acceleration during standing than before spaceflight, and in some, orthostatic hypotension and presyncope. Adaptation of the sympathetic nervous system occurring during spaceflight may be responsible for these postflight alterations. We tested the hypotheses that exposure to microgravity reduces sympathetic neural outflow and impairs sympathetic neural responses to orthostatic stress. We measured heart rate, photoplethysmographic finger arterial pressure, peroneal nerve muscle sympathetic activity and plasma noradrenaline spillover and clearance, in male astronauts before, during (flight day 12 or 13) and after the 16 day Neurolab space shuttle mission. Measurements were made during supine rest and orthostatic stress, as simulated on Earth and in space by 7 min periods of 15 and 30 mmHg lower body suction. Mean (± s.e.m.) heart rates before lower body suction were similar pre–flight and in flight. Heart rate responses to −30 mmHg were greater in flight (from 56 ± 4 to 72 ± 4 beats min−1) than pre–flight (from 56 ± 4 at rest to 62 ± 4 beats min−1, P < 0.05). Noradrenaline spillover and clearance were increased from pre–flight levels during baseline periods and during lower body suction, both in flight (n = 3) and on post–flight days 1 or 2 (n = 5, P < 0.05). In–flight baseline sympathetic nerve activity was increased above pre–flight levels (by 10–33 %) in the same three subjects in whom noradrenaline spillover and clearance were increased. The sympathetic response to 30 mmHg lower body suction was at pre–flight levels or higher in each subject (35 pre–flight vs. 40 bursts min−1 in flight). No astronaut experienced presyncope during lower body suction in space (or during upright tilt following the Neurolab mission). We conclude that in space, baseline sympathetic neural outflow is increased moderately and sympathetic responses to lower body suction are exaggerated. Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels. PMID:11773339

  17. Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space

    NASA Technical Reports Server (NTRS)

    Ertl, Andrew C.; Diedrich, Andre; Biaggioni, Italo; Levine, Benjamin D.; Robertson, Rose Marie; Cox, James F.; Zuckerman, Julie H.; Pawelczyk, James A.; Ray, Chester A.; Buckey, Jay C Jr; hide

    2002-01-01

    Astronauts returning from space have reduced red blood cell masses, hypovolaemia and orthostatic intolerance, marked by greater cardio-acceleration during standing than before spaceflight, and in some, orthostatic hypotension and presyncope. Adaptation of the sympathetic nervous system occurring during spaceflight may be responsible for these postflight alterations. We tested the hypotheses that exposure to microgravity reduces sympathetic neural outflow and impairs sympathetic neural responses to orthostatic stress. We measured heart rate, photoplethysmographic finger arterial pressure, peroneal nerve muscle sympathetic activity and plasma noradrenaline spillover and clearance, in male astronauts before, during (flight day 12 or 13) and after the 16 day Neurolab space shuttle mission. Measurements were made during supine rest and orthostatic stress, as simulated on Earth and in space by 7 min periods of 15 and 30 mmHg lower body suction. Mean (+/- S.E.M.) heart rates before lower body suction were similar pre-flight and in flight. Heart rate responses to -30 mmHg were greater in flight (from 56 +/- 4 to 72 +/- 4 beats min(-1)) than pre-flight (from 56 +/- 4 at rest to 62 +/- 4 beats min(-1), P < 0.05). Noradrenaline spillover and clearance were increased from pre-flight levels during baseline periods and during lower body suction, both in flight (n = 3) and on post-flight days 1 or 2 (n = 5, P < 0.05). In-flight baseline sympathetic nerve activity was increased above pre-flight levels (by 10-33 %) in the same three subjects in whom noradrenaline spillover and clearance were increased. The sympathetic response to 30 mmHg lower body suction was at pre-flight levels or higher in each subject (35 pre-flight vs. 40 bursts min(-1) in flight). No astronaut experienced presyncope during lower body suction in space (or during upright tilt following the Neurolab mission). We conclude that in space, baseline sympathetic neural outflow is increased moderately and sympathetic responses to lower body suction are exaggerated. Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels.

  18. Applying the Verona coding definitions of emotional sequences (VR-CoDES) to code medical students' written responses to written case scenarios: Some methodological and practical considerations.

    PubMed

    Ortwein, Heiderose; Benz, Alexander; Carl, Petra; Huwendiek, Sören; Pander, Tanja; Kiessling, Claudia

    2017-02-01

    To investigate whether the Verona Coding Definitions of Emotional Sequences to code health providers' responses (VR-CoDES-P) can be used for assessment of medical students' responses to patients' cues and concerns provided in written case vignettes. Student responses in direct speech to patient cues and concerns were analysed in 21 different case scenarios using VR-CoDES-P. A total of 977 student responses were available for coding, and 857 responses were codable with the VR-CoDES-P. In 74.6% of responses, the students used either a "reducing space" statement only or a "providing space" statement immediately followed by a "reducing space" statement. Overall, the most frequent response was explicit information advice (ERIa) followed by content exploring (EPCEx) and content acknowledgement (EPCAc). VR-CoDES-P were applicable to written responses of medical students when they were phrased in direct speech. The application of VR-CoDES-P is reliable and feasible when using the differentiation of "providing" and "reducing space" responses. Communication strategies described by students in non-direct speech were difficult to code and produced many missings. VR-CoDES-P are useful for analysis of medical students' written responses when focusing on emotional issues. Students need precise instructions for their response in the given test format. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Maximum Oxygen Uptake During and After Long-Duration Space Flight

    NASA Technical Reports Server (NTRS)

    Moore, Alan D., Jr.; Evetts, Simon N.; Feiveson, Alan H.; Lee, Stuart M. C.; McCleary. Frank A.; Platts, Steven H.

    2010-01-01

    Decreased maximum oxygen consumption (VO2max) during and after space flight may impair a crewmember s ability to perform mission-critical work that is high intensity and/or long duration in nature (Human Research Program Integrated Research Plan Risk 2.1.2: Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity). When VO2max was measured in Space Shuttle experiments, investigators reported that it did not change during short-duration space flight but decreased immediately after flight. Similar conclusions, based on the heart rate (HR) response of Skylab crewmembers, were made previously concerning long-duration space flight. Specifically, no change in the in-flight exercise HR response in 8 of 9 Skylab crewmembers indicated that VO2max was maintained during flight, but the elevated exercise HR after flight indicated that VO2max was decreased after landing. More recently, a different pattern of in-flight exercise HR response, and assumed changes in VO2max, emerged from routine testing of International Space Station (ISS) crewmembers. Most ISS crewmembers experience an elevated in-flight exercise HR response early in their mission, with a gradual return toward preflight levels as the mission progresses. Similar to previous reports, exercise HR is elevated after ISS missions and returns to preflight levels by 30 days after landing. VO2max has not been measured either during or after long-duration space flight. The purposes of the ISS VO2max experiment are (1) to measure VO2max during and after long-duration spaceflight, and (2) to determine if submaximal exercise test results can be used to accurately estimate VO 2max.

  20. Effects of space vacuum and solar ultraviolet irradiation (254 nanometers) on the colony forming ability of Bacillus subtilis spores

    NASA Technical Reports Server (NTRS)

    Buecker, H.; Horneck, G.; Wollenhaupt, H.

    1973-01-01

    Bacillus subtilis spores are highly resistant to harsh environments. Therefore, in the Apollo 16 Microbial Response to Space Environment Experiment (M191), these spores were exposed to space vacuum or solar ultraviolet irradiation, or both, to estimate the change of survival for terrestrial organisms in space. The survival of the spores was determined in terms of colony-forming ability. Comparison of the flight results with results of simulation experiments on earth applying high vacuum or ultraviolet irradiation, or both, revealed no remarkable difference. Simultaneous exposure to both these space factors resulted in a synergistic effect (that is, an ultraviolet supersensitivity). Therefore, the change of survival in space is assumed to depend on the degree of protection against solar ultraviolet irradiation.

  1. Operationally Responsive Space Launch for Space Situational Awareness Missions

    NASA Astrophysics Data System (ADS)

    Freeman, T.

    The United States Space Situational Awareness capability continues to be a key element in obtaining and maintaining the high ground in space. Space Situational Awareness satellites are critical enablers for integrated air, ground and sea operations, and play an essential role in fighting and winning conflicts. The United States leads the world space community in spacecraft payload systems from the component level into spacecraft and in the development of constellations of spacecraft. This position is founded upon continued government investment in research and development in space technology, which is clearly reflected in the Space Situational Awareness capabilities and the longevity of these missions. In the area of launch systems that support Space Situational Awareness, despite the recent development of small launch vehicles, the United States launch capability is dominated by unresponsive and relatively expensive launchers in the Expandable, Expendable Launch Vehicles (EELV). The EELV systems require an average of six to eight months from positioning on the launch table until liftoff. Access to space requires maintaining a robust space transportation capability, founded on a rigorous industrial and technology base. To assure access to space, the United States directed Air Force Space Command to develop the capability for operationally responsive access to space and use of space to support national security, including the ability to provide critical space capabilities in the event of a failure of launch or on-orbit capabilities. Under the Air Force Policy Directive, the Air Force will establish, organize, employ, and sustain space forces necessary to execute the mission and functions assigned including rapid response to the National Command Authorities and the conduct of military operations across the spectrum of conflict. Air Force Space Command executes the majority of spacelift operations for DoD satellites and other government and commercial agencies. The Command researched and identified a course of action that has maximized operationally responsive space for Low-Earth-Orbit Space Situational Awareness assets. On 1 Aug 06, Air Force Space Command activated the Space Development and Test Wing (SDTW) to perform development, test and evaluation of Air Force space systems and to execute advanced space deployment and demonstration projects to exploit new concepts and technologies, and rapidly migrate capabilities to the warfighter. The SDTW charged the Launch Test Squadron (LTS) to develop the operationally responsive spacelift capability for Low-Earth-Orbit Space Situational Awareness assets. The LTS created and executed a space enterprise strategy to place small payloads (1500 pounds), at low cost (less than 28M to 30M per launch), repeatable and rapidly into 100 - 255 nautical miles orbits. In doing so, the squadron provides scalable launch support services including program management support, engineering support, payload integration, and post-test evaluation for space systems. The Air Force, through the SDTW/LTS, will continue to evolve as the spacelift execution arm for Space Situational Awareness by creating small, less-expensive, repeatable and operationally responsive space launch capability.

  2. KENNEDY SPACE CENTER, FLA. - Dignitaries, invited guests, space center employees, and the media show their appreciation for the speakers at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

    NASA Image and Video Library

    2003-11-19

    KENNEDY SPACE CENTER, FLA. - Dignitaries, invited guests, space center employees, and the media show their appreciation for the speakers at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  3. 14 CFR 1214.702 - Authority and responsibility of the Space Shuttle commander.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Authority and responsibility of the Space Shuttle commander. 1214.702 Section 1214.702 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT The Authority of the Space Shuttle Commander § 1214.702 Authority and responsibility...

  4. 14 CFR 1214.702 - Authority and responsibility of the Space Shuttle commander.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Authority and responsibility of the Space Shuttle commander. 1214.702 Section 1214.702 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT The Authority of the Space Shuttle Commander § 1214.702 Authority and responsibility...

  5. 14 CFR 1214.702 - Authority and responsibility of the Space Shuttle commander.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Authority and responsibility of the Space Shuttle commander. 1214.702 Section 1214.702 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT The Authority of the Space Shuttle Commander § 1214.702 Authority and responsibility...

  6. 14 CFR 1214.702 - Authority and responsibility of the Space Shuttle commander.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Authority and responsibility of the Space Shuttle commander. 1214.702 Section 1214.702 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT The Authority of the Space Shuttle Commander § 1214.702 Authority and responsibility...

  7. Quality of and access to green space in relation to psychological distress: results from a population-based cross-sectional study as part of the EURO-URHIS 2 project.

    PubMed

    Pope, D; Tisdall, R; Middleton, J; Verma, A; van Ameijden, E; Birt, C; Macherianakis, A; Bruce, N G

    2018-02-01

    Psychological distress (PD) (mental ill-health) has a frequency between 5 and 25% in urban populations, and there is mounting evidence that access to green space might reduce its occurrence. Evidence suggests that the quality of green space is as important as accessibility in promoting mental well-being. A pilot study for EURO-URHIS 2 allowed investigation of access to green space in relation to PD in a deprived urban population in the UK. An adult urban health indicator questionnaire, including the GHQ-12 and validated questions on access to and quality of green space, was sent to a stratified random sample of 1680 adults drawn from one general practice list in Sandwell, UK. Multivariable logistic regression was used to determine associations between attributes of green space and PD adjusting for age, sex and levels of deprivation. There were 578 (35%) completed responses. The reported prevalence of PD [n = 131 (22.7%)] was significantly greater than national England and Wales estimates. As well as accessibility (OR = 0.58; 95% CI = 0.35, 0.96) and sufficiency (OR = 0.12; 95% CI = 0.39, 0.89) of green spaces, having the ability to use them for relaxation and recreation were significantly associated with reduced PD [OR = 0.13 (0.42, 0.94) and OR = 0.11 (0.34, 0.80), respectively]. In addition, a dose-response relationship between number of positive green space attributes and PD was identified (P < 0.05). This population-based study in a deprived urban UK population demonstrates an association, and some dose-response relationship, between access to and quality of green spaces with reduced PD. The cross-sectional design and use of subjective measures limit interpretation of causality. More knowledge is needed on how UK planning affects green spaces and the potential mental health consequences. © The Author 2015. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  8. The evolution of Earth Observation satellites in Europe and its impact on the performance of emergency response services

    NASA Astrophysics Data System (ADS)

    Denis, Gil; de Boissezon, Hélène; Hosford, Steven; Pasco, Xavier; Montfort, Bruno; Ranera, Franck

    2016-10-01

    The paper reviews the evolution of Earth Observation systems in Europe and Worldwide and analyses the potential impact of their performance in support of emergency response services. Earth Observation satellites play already a significant role in supporting the action of first responders in case of major disasters. The main principle is the coordinated use of satellites in order to ensure a rapid response and the timely delivery of images and geospatial information of the area affected by the event. The first part of the paper reviews the main instruments and evaluates their current performance. The International Charter ;Space and Major Disasters;, signed in October 2000, was the first international initiative aimed at establishing a unified system for the acquisition of space data. The charter is a cooperation agreement between space agencies and operators of space systems. At regional level, a similar instrument exists in Asia: Sentinel-Asia. In the frame of the European programme Copernicus, the emergency management service was launched in 2009. Geo-information products derived from space imagery are delivered during all phases of the emergency management cycle, in either rush or non-rush mode, free of charge for the users. In both cases, the capacities were historically drawn from national missions, funded with public money and directly operated by the space agencies or by national operators.

  9. 14 CFR § 1214.702 - Authority and responsibility of the Space Shuttle commander.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Authority and responsibility of the Space Shuttle commander. § 1214.702 Section § 1214.702 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT The Authority of the Space Shuttle Commander § 1214.702 Authority and responsibility...

  10. Plasticity of Arabidopsis root gravitropism throughout a multidimensional condition space quantified by automated image analysis.

    PubMed

    Brooks, Tessa L Durham; Miller, Nathan D; Spalding, Edgar P

    2010-01-01

    Plant development is genetically determined but it is also plastic, a fundamental duality that can be investigated provided large number of measurements can be made in various conditions. Plasticity of gravitropism in wild-type Arabidopsis (Arabidopsis thaliana) seedling roots was investigated using automated image acquisition and analysis. A bank of computer-controlled charge-coupled device cameras acquired images with high spatiotemporal resolution. Custom image analysis algorithms extracted time course measurements of tip angle and growth rate. Twenty-two discrete conditions defined by seedling age (2, 3, or 4 d), seed size (extra small, small, medium, or large), and growth medium composition (simple or rich) formed the condition space sampled with 1,216 trials. Computational analyses including dimension reduction by principal components analysis, classification by k-means clustering, and differentiation by wavelet convolution showed distinct response patterns within the condition space, i.e. response plasticity. For example, 2-d-old roots (regardless of seed size) displayed a response time course similar to those of roots from large seeds (regardless of age). Enriching the growth medium with nutrients suppressed response plasticity along the seed size and age axes, possibly by ameliorating a mineral deficiency, although analysis of seeds did not identify any elements with low levels on a per weight basis. Characterizing relationships between growth rate and tip swing rate as a function of condition cast gravitropism in a multidimensional response space that provides new mechanistic insights as well as conceptually setting the stage for mutational analysis of plasticity in general and root gravitropism in particular.

  11. Plasticity of Arabidopsis Root Gravitropism throughout a Multidimensional Condition Space Quantified by Automated Image Analysis1[W][OA

    PubMed Central

    Durham Brooks, Tessa L.; Miller, Nathan D.; Spalding, Edgar P.

    2010-01-01

    Plant development is genetically determined but it is also plastic, a fundamental duality that can be investigated provided large number of measurements can be made in various conditions. Plasticity of gravitropism in wild-type Arabidopsis (Arabidopsis thaliana) seedling roots was investigated using automated image acquisition and analysis. A bank of computer-controlled charge-coupled device cameras acquired images with high spatiotemporal resolution. Custom image analysis algorithms extracted time course measurements of tip angle and growth rate. Twenty-two discrete conditions defined by seedling age (2, 3, or 4 d), seed size (extra small, small, medium, or large), and growth medium composition (simple or rich) formed the condition space sampled with 1,216 trials. Computational analyses including dimension reduction by principal components analysis, classification by k-means clustering, and differentiation by wavelet convolution showed distinct response patterns within the condition space, i.e. response plasticity. For example, 2-d-old roots (regardless of seed size) displayed a response time course similar to those of roots from large seeds (regardless of age). Enriching the growth medium with nutrients suppressed response plasticity along the seed size and age axes, possibly by ameliorating a mineral deficiency, although analysis of seeds did not identify any elements with low levels on a per weight basis. Characterizing relationships between growth rate and tip swing rate as a function of condition cast gravitropism in a multidimensional response space that provides new mechanistic insights as well as conceptually setting the stage for mutational analysis of plasticity in general and root gravitropism in particular. PMID:19923240

  12. Effects of the space flight environment on the immune system

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, Gerald; Butel, Janet S.; Shearer, William T.

    2003-01-01

    Space flight conditions have a dramatic effect on a variety of physiologic functions of mammals, including muscle, bone, and neurovestibular function. Among the physiological functions that are affected when humans or animals are exposed to space flight conditions is the immune response. The focus of this review is on the function of the immune system in space flight conditions during actual space flights, as well as in models of space flight conditions on the earth. The experiments were carried out in tissue culture systems, in animal models, and in human subjects. The results indicate that space flight conditions alter cell-mediated immune responses, including lymphocyte proliferation and subset distribution, and cytokine production. The mechanism(s) of space flight-induced alterations in immune system function remain(s) to be established. It is likely, however, that multiple factors, including microgravity, stress, neuroendocrine factors, sleep disruption, and nutritional factors, are involved in altering certain functions of the immune system. Such alterations could lead to compromised defenses against infections and tumors.

  13. Space Acquisitions: GAO Assessment of DOD Responsive Launch Report

    DTIC Science & Technology

    2015-10-29

    foreign governments or industry ; 2. conditions or requirements for responsive launch that would provide the necessary military value; 3. various...Facebook, Flickr, Twitter, and YouTube. Subscribe to our RSS Feeds or E-mail Updates. Listen to our Podcasts . Visit GAO on the web at www.gao.gov

  14. 14 CFR 1259.401 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Responsibilities. 1259.401 Section 1259.401 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant College and Consortium Designation § 1259.401 Responsibilities. Each...

  15. 14 CFR 1259.401 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Responsibilities. 1259.401 Section 1259.401 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant College and Consortium Designation § 1259.401 Responsibilities. Each...

  16. 14 CFR 1259.401 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Responsibilities. 1259.401 Section 1259.401 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant College and Consortium Designation § 1259.401 Responsibilities. Each...

  17. Validation of Walking Trails for the Urban TrainingTM of Chronic Obstructive Pulmonary Disease Patients

    PubMed Central

    Arbillaga-Etxarri, Ane; Torrent-Pallicer, Jaume; Gimeno-Santos, Elena; Barberan-Garcia, Anael; Delgado, Anna; Balcells, Eva; Rodríguez, Diego A.; Vilaró, Jordi; Vall-Casas, Pere; Irurtia, Alfredo; Rodriguez-Roisin, Robert; Garcia-Aymerich, Judith

    2016-01-01

    Purpose Accessible interventions to train patients with chronic obstructive pulmonary disease (COPD) are needed. We designed urban trails of different intensities (low, moderate and high) in different types of public spaces (boulevard, beach and park). We aimed to validate the trails’ design by assessing the physiological response to unsupervised walking trails of: (1) different intensities in COPD patients, and (2) same intensity from different public spaces in healthy adults. Methods On different days and under standardized conditions, 10 COPD patients walked the three intensity trails designed in a boulevard space, and 10 healthy subjects walked the three intensity trails in three different spaces. We measured physiological response and energy expenditure using a gas analyzer. We compared outcomes across trails intensity and/or spaces using mixed-effects linear regression. Results In COPD patients, physiological response and energy expenditure increased significantly according to the trails intensity: mean (SD) peak V˙O2 15.9 (3.5), 17.4 (4.7), and 17.7 (4.4) mL/min/kg (p-trend = 0.02), and MET-min 60 (23), 64 (26), 72 (31) (p-trend<0.01) in low, moderate and high intensity trails, respectively. In healthy subjects there were no differences in physiological response to walking trails of the same intensity across different spaces. Conclusions We validated the trails design for the training of COPD patients by showing that the physiological response to and energy expenditure on unsupervised walking these trails increased according to the predefined trails’ intensity and did not change across trails of the same intensity in different public space. Walkable public spaces allow the design of trails that could be used for the training of COPD patients in the community. PMID:26766184

  18. Validation of Walking Trails for the Urban Training™ of Chronic Obstructive Pulmonary Disease Patients.

    PubMed

    Arbillaga-Etxarri, Ane; Torrent-Pallicer, Jaume; Gimeno-Santos, Elena; Barberan-Garcia, Anael; Delgado, Anna; Balcells, Eva; Rodríguez, Diego A; Vilaró, Jordi; Vall-Casas, Pere; Irurtia, Alfredo; Rodriguez-Roisin, Robert; Garcia-Aymerich, Judith

    2016-01-01

    Accessible interventions to train patients with chronic obstructive pulmonary disease (COPD) are needed. We designed urban trails of different intensities (low, moderate and high) in different types of public spaces (boulevard, beach and park). We aimed to validate the trails' design by assessing the physiological response to unsupervised walking trails of: (1) different intensities in COPD patients, and (2) same intensity from different public spaces in healthy adults. On different days and under standardized conditions, 10 COPD patients walked the three intensity trails designed in a boulevard space, and 10 healthy subjects walked the three intensity trails in three different spaces. We measured physiological response and energy expenditure using a gas analyzer. We compared outcomes across trails intensity and/or spaces using mixed-effects linear regression. In COPD patients, physiological response and energy expenditure increased significantly according to the trails intensity: mean (SD) peak V̇O2 15.9 (3.5), 17.4 (4.7), and 17.7 (4.4) mL/min/kg (p-trend = 0.02), and MET-min 60 (23), 64 (26), 72 (31) (p-trend<0.01) in low, moderate and high intensity trails, respectively. In healthy subjects there were no differences in physiological response to walking trails of the same intensity across different spaces. We validated the trails design for the training of COPD patients by showing that the physiological response to and energy expenditure on unsupervised walking these trails increased according to the predefined trails' intensity and did not change across trails of the same intensity in different public space. Walkable public spaces allow the design of trails that could be used for the training of COPD patients in the community.

  19. 14 CFR 1216.303 - Responsibilities of NASA officials.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Responsibilities of NASA officials. 1216... Responsibilities of NASA officials. (a) The Associate Administrator for Management or designee, who is responsible... considered in all NASA planning and decisionmaking, shall: (1) Monitor these processes to ensure that the...

  20. 14 CFR 1216.303 - Responsibilities of NASA officials.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Responsibilities of NASA officials. 1216... Responsibilities of NASA officials. (a) The Associate Administrator for Management or designee, who is responsible... considered in all NASA planning and decisionmaking, shall: (1) Monitor these processes to ensure that the...

  1. Disaster response and the international charter program

    USGS Publications Warehouse

    Stryker, Timothy; Jones, Brenda

    2009-01-01

    In a meeting held in Vienna, Austria in 1999, a small group of space agencies conceived and approved a program to provide emergency response satellite data to those affected by disasters anywhere in the world. The purpose of this group, which came to be known as the “International Charter - Space and Major Disasters”, is to promote cooperation among space agencies in the use of satellite data to manage crises during and after disasters. When tropical storms, floods, oil spills, earthquakes, landslides, volcanoes or fires endanger human life, the Charter member agencies provide valuable information about these events’ extent and impact.

  2. 14 CFR 1259.603 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Responsibilities. 1259.603 Section 1259.603 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.603 Responsibilities. (a) The Panel shall advise the...

  3. 14 CFR 1259.603 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Responsibilities. 1259.603 Section 1259.603 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.603 Responsibilities. (a) The Panel shall advise the...

  4. 14 CFR 1259.603 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Responsibilities. 1259.603 Section 1259.603 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.603 Responsibilities. (a) The Panel shall advise the...

  5. 14 CFR 1259.603 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Responsibilities. 1259.603 Section 1259.603 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.603 Responsibilities. (a) The Panel shall advise the...

  6. Expert Water Quality Panel Review of Responses to the NASA Request for Information for the International Space Station On-Board Environmental Monitoring System

    NASA Technical Reports Server (NTRS)

    Fishman, Julianna L.; Mudgett, Paul D.; Packham, Nigel J.; Schultz, John R.; Straub, John E., II

    2005-01-01

    On August 9, 2003, NASA, with the cooperative support of the Vehicle Office of the International Space Station Program, the Advanced Human Support Technology Program, and the Johnson Space Center Habitability and Environmental Factors Office released a Request for Information, or RFI, to identify next-generation environmental monitoring systems that have demonstrated ability or the potential to meet defined requirements for monitoring air and water quality onboard the International Space Station. This report summarizes the review and analysis of the proposed solutions submitted to meet the water quality monitoring requirements. Proposals were to improve upon the functionality of the existing Space Station Total Organic Carbon Analyzer (TOCA) and monitor additional contaminants in water samples. The TOCA is responsible for in-flight measurement of total organic carbon, total inorganic carbon, total carbon, pH, and conductivity in the Space Station potable water supplies. The current TOCA requires hazardous reagents to accomplish the carbon analyses. NASA is using the request for information process to investigate new technologies that may improve upon existing capabilities, as well as reduce or eliminate the need for hazardous reagents. Ideally, a replacement for the TOCA would be deployed in conjunction with the delivery of the Node 3 water recovery system currently scheduled for November 2007.

  7. Rule Space, the Product Space of Two Score Components in Signed-Number Subtraction: An Approach to Dealing with Inconsistent Use of Erroneous Rules.

    ERIC Educational Resources Information Center

    Tatsuoka, Kikumi K.; Baillie, Robert

    A 40-item free response test on signed-number subtraction was administered to 172 eighth graders. Their responses are viewed as consisting of two different components, the sign and absolute value. Each component is scored zero for wrong or one for correct, yielding a score of one only when both components have scores of one. By taking the values…

  8. 14 CFR § 1259.401 - Responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Responsibilities. § 1259.401 Section § 1259.401 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant College and Consortium Designation § 1259.401 Responsibilities...

  9. Log-polar mapping-based scale space tracking with adaptive target response

    NASA Astrophysics Data System (ADS)

    Li, Dongdong; Wen, Gongjian; Kuai, Yangliu; Zhang, Ximing

    2017-05-01

    Correlation filter-based tracking has exhibited impressive robustness and accuracy in recent years. Standard correlation filter-based trackers are restricted to translation estimation and equipped with fixed target response. These trackers produce an inferior performance when encountered with a significant scale variation or appearance change. We propose a log-polar mapping-based scale space tracker with an adaptive target response. This tracker transforms the scale variation of the target in the Cartesian space into a shift along the logarithmic axis in the log-polar space. A one-dimensional scale correlation filter is learned online to estimate the shift along the logarithmic axis. With the log-polar representation, scale estimation is achieved accurately without a multiresolution pyramid. To achieve an adaptive target response, a variance of the Gaussian function is computed from the response map and updated online with a learning rate parameter. Our log-polar mapping-based scale correlation filter and adaptive target response can be combined with any correlation filter-based trackers. In addition, the scale correlation filter can be extended to a two-dimensional correlation filter to achieve joint estimation of the scale variation and in-plane rotation. Experiments performed on an OTB50 benchmark demonstrate that our tracker achieves superior performance against state-of-the-art trackers.

  10. 14 CFR § 1259.603 - Responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Responsibilities. § 1259.603 Section § 1259.603 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.603 Responsibilities. (a) The Panel shall...

  11. Arbitrary numbers counter fair decisions: trails of markedness in card distribution.

    PubMed

    Schroeder, Philipp A; Pfister, Roland

    2015-01-01

    Converging evidence from controlled experiments suggests that the mere processing of a number and its attributes such as value or parity might affect free choice decisions between different actions. For example the spatial numerical associations of response codes (SNARC) effect indicates the magnitude of a digit to be associated with a spatial representation and might therefore affect spatial response choices (i.e., decisions between a "left" and a "right" option). At the same time, other (linguistic) features of a number such as parity are embedded into space and might likewise prime left or right responses through feature words [odd or even, respectively; markedness association of response codes (MARC) effect]. In this experiment we aimed at documenting such influences in a natural setting. We therefore assessed number-space and parity-space association effects by exposing participants to a fair distribution task in a card playing scenario. Participants drew cards, read out loud their number values, and announced their response choice, i.e., dealing it to a left vs. right player, indicated by Playmobil characters. Not only did participants prefer to deal more cards to the right player, the card's digits also affected response choices and led to a slightly but systematically unfair distribution, supported by a regular SNARC effect and counteracted by a reversed MARC effect. The experiment demonstrates the impact of SNARC- and MARC-like biases in free choice behavior through verbal and visual numerical information processing even in a setting with high external validity.

  12. Experiment K-6-07. Metabolic and morphologic properties of muscle fibers after spaceflight

    NASA Technical Reports Server (NTRS)

    Edgerton, R.; Miu, B.; Martin, Thomas P.; Roy, R.; Marini, J.; Leger, J. J.; Oganov, V.; Ilyina-Kakueva, E.

    1990-01-01

    The present study demonstrates that the general capability of skeletal muscle to maintain its proteins decreases rapidly in response to space flight. The present findings suggest further that the magnitude of enzymatic and cell volumes changes in response to space flight depend on several factors including the muscle and its fiber type composition. It appears that in order to associate physiological relevance to the observed enzymatic changes, cell volume should be considered also. Although it remains unclear as to the stimulus, or lack of stimulus, that triggers the rapid changes in muscle proteins in response to space flight, ground-based models of muscle atrophy suggest that the reduction in mechanical loading of muscle may be more important than the total amount of activation over a 24-hr period.

  13. Response of lymphocytes to a mitogenic stimulus during spaceflight

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, Gerald

    1989-01-01

    Several studies were performed that demonstrate that immunological activities of lymphocytes can be affected by spaceflight or by models that attempt to simulate some aspects of weightlessness. Included among these are the responses of lymphocytes to external stimuli such as mitogens and viruses. When cultures of lymphocytes were flown in space, the ability of the lymphocytes to respond to mitogens was inhibited. Similar results were obtained when lymphocytes from astronauts or animals just returned from space were placed into culture immediately upon return to earth, and when models of hypogravity were used. Lymphocytes placed in culture during spaceflights produced enhanced levels of interferon compared to control cultures. When cultures of lymphocytes were prepared for cosmonauts or rodents immediately upon return to earth, interferon production was inhibited. These results suggest that space flight can have profound effects on lymphocyte function, and that effects on isolated cells may be different from that on cells in the whole organism.

  14. Insectivorous bats respond to vegetation complexity in urban green spaces.

    PubMed

    Suarez-Rubio, Marcela; Ille, Christina; Bruckner, Alexander

    2018-03-01

    Structural complexity is known to determine habitat quality for insectivorous bats, but how bats respond to habitat complexity in highly modified areas such as urban green spaces has been little explored. Furthermore, it is uncertain whether a recently developed measure of structural complexity is as effective as field-based surveys when applied to urban environments. We assessed whether image-derived structural complexity (MIG) was as/more effective than field-based descriptors in this environment and evaluated the response of insectivorous bats to structural complexity in urban green spaces. Bat activity and species richness were assessed with ultrasonic devices at 180 locations within green spaces in Vienna, Austria. Vegetation complexity was assessed using 17 field-based descriptors and by calculating the mean information gain (MIG) using digital images. Total bat activity and species richness decreased with increasing structural complexity of canopy cover, suggesting maneuverability and echolocation (sensorial) challenges for bat species using the canopy for flight and foraging. The negative response of functional groups to increased complexity was stronger for open-space foragers than for edge-space foragers. Nyctalus noctula , a species foraging in open space, showed a negative response to structural complexity, whereas Pipistrellus pygmaeus , an edge-space forager, was positively influenced by the number of trees. Our results show that MIG is a useful, time- and cost-effective tool to measure habitat complexity that complemented field-based descriptors. Response of insectivorous bats to structural complexity was group- and species-specific, which highlights the need for manifold management strategies (e.g., increasing or reinstating the extent of ground vegetation cover) to fulfill different species' requirements and to conserve insectivorous bats in urban green spaces.

  15. 14 CFR 1214.402 - International Space Station crewmember responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true International Space Station crewmember responsibilities. 1214.402 Section 1214.402 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT International Space Station Crew § 1214.402 International Space Station crewmember...

  16. 14 CFR 1214.402 - International Space Station crewmember responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false International Space Station crewmember responsibilities. 1214.402 Section 1214.402 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT International Space Station Crew § 1214.402 International Space Station crewmember...

  17. Plant-centered biosystems in space environments: technological concepts for developing a plant genetic assessment and control system.

    PubMed

    Lomax, Terri L; Findlay, Kirk A; White, T J; Winner, William E

    2003-06-01

    Plants will play an essential role in providing life support for any long-term space exploration or habitation. We are evaluating the feasibility of an adaptable system for measuring the response of plants to any unique space condition and optimizing plant performance under those conditions. The proposed system is based on a unique combination of systems including the rapid advances in the field of plant genomics, microarray technology for measuring gene expression, bioinformatics, gene pathways and networks, physiological measurements in controlled environments, and advances in automation and robotics. The resulting flexible module for monitoring and optimizing plant responses will be able to be inserted as a cassette into a variety of platforms and missions for either experimental or life support purposes. The results from future plant functional genomics projects have great potential to be applied to those plant species most likely to be used in space environments. Eventually, it will be possible to use the plant genetic assessment and control system to optimize the performance of any plant in any space environment. In addition to allowing the effective control of environmental parameters for enhanced plant productivity and other life support functions, the proposed module will also allow the selection or engineering of plants to thrive in specific space environments. The proposed project will advance human exploration of space in the near- and mid-term future on the International Space Station and free-flying satellites and in the far-term for longer duration missions and eventual space habitation.

  18. Neuroscience Investigations: An Overview of Studies Conducted

    NASA Technical Reports Server (NTRS)

    Reschke, Millard F.

    1999-01-01

    The neural processes that mediate human spatial orientation and adaptive changes occurring in response to the sensory rearrangement encountered during orbital flight are primarily studied through second and third order responses. In the Extended Duration Orbiter Medical Project (EDOMP) neuroscience investigations, the following were measured: (1) eye movements during acquisition of either static or moving visual targets, (2) postural and locomotor responses provoked by unexpected movement of the support surface, changes in the interaction of visual, proprioceptive, and vestibular information, changes in the major postural muscles via descending pathways, or changes in locomotor pathways, and (3) verbal reports of perceived self-orientation and self-motion which enhance and complement conclusions drawn from the analysis of oculomotor, postural, and locomotor responses. In spaceflight operations, spatial orientation can be defined as situational awareness, where crew member perception of attitude, position, or motion of the spacecraft or other objects in three-dimensional space, including orientation of one's own body, is congruent with actual physical events. Perception of spatial orientation is determined by integrating information from several sensory modalities. This involves higher levels of processing within the central nervous system that control eye movements, locomotion, and stable posture. Spaceflight operational problems occur when responses to the incorrectly perceived spatial orientation are compensatory in nature. Neuroscience investigations were conducted in conjunction with U. S. Space Shuttle flights to evaluate possible changes in the ability of an astronaut to land the Shuttle or effectively perform an emergency post-landing egress following microgravity adaptation during space flights of variable length. While the results of various sensory motor and spatial orientation tests could have an impact on future space flights, our knowledge of sensorimotor adaptation to spaceflight is limited, and the future application of effective countermeasures depends, in large part, on the results from appropriate neuroscience investigations. Therefore, the objective of the neuroscience investigations could have a negative effect on mission success. The Neuroscience Laboratory, Johnson Space Center (JSC), implemented three integrated Detailed Supplementary Objectives (DSO) designed to investigate spatial orientation and the associated compensatory responses as a part of the EDOMP. The four primary goals were (1) to establish a normative database of vestibular and associated sensory changes in response to spaceflight, (2) to determine the underlying etiology of neurovestibular and sensory motor changes associated with exposure to microgravity and the subsequent return to Earth, (3) to provide immediate feedback to spaceflight crews regarding potential countermeasures that could improve performance and safety during and after flight, and (4) to take under consideration appropriate designs for preflight, in-flight, and postflight countermeasures that could be implemented for future flights.

  19. Internet Geo-Location

    DTIC Science & Technology

    2017-12-01

    space while absolutely refraining from issuing any measurement probes of its own, either before or after it is presented with the IP addresses... space , IP geolocation 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON ROBERT...since it computes predictions for the entire IP address space while absolutely refraining from issuing any measurement probes of its own, either

  20. 14 CFR 1216.311 - Emergency responses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....311 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ENVIRONMENTAL QUALITY Subpart... immediate impacts of the emergency needed to mitigate harm to life, property, or resources. When taking such... of Part 1216—Acronyms and Definitions CatExCategorical Exclusion CEQCouncil on Environmental Quality...

  1. 14 CFR 1212.101 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Basic Policy... not limited to, education, financial transactions, medical history, and criminal or employment history... term system manager means the NASA official who is responsible for a system of records as designated in...

  2. 14 CFR 1212.101 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Basic Policy... not limited to, education, financial transactions, medical history, and criminal or employment history... term system manager means the NASA official who is responsible for a system of records as designated in...

  3. 14 CFR 1212.101 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Basic Policy... not limited to, education, financial transactions, medical history, and criminal or employment history... term system manager means the NASA official who is responsible for a system of records as designated in...

  4. Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest

    NASA Technical Reports Server (NTRS)

    Lee, S. M.; Bennett, B. S.; Hargens, A. R.; Watenpaugh, D. E.; Ballard, R. E.; Murthy, G.; Ford, S. R.; Fortney, S. M.

    1997-01-01

    Adaptation to bed rest or space flight is accompanied by an impaired ability to exercise in an upright position. We hypothesized that a daily, 30-min bout of intense, interval exercise in upright posture or supine against lower body negative pressure (LBNP) would maintain upright exercise heart rate and respiratory responses after bed rest. Twenty-four men (31 +/- 3 yr) underwent 5 d of 6 degree head-down tilt: eight performed no exercise (CON), eight performed upright treadmill exercise (UPex), and eight performed supine treadmill exercise against LBNP at -51.3 +/- 0.4 mm Hg (LBNPex). Submaximal treadmill exercise responses (56, 74, and 85% of VO2peak) were measured pre- and post-bed rest. In CON, submaximal heart rate, respiratory exchange ratio, and ventilation were significantly greater (P < or = 0.05) after bed rest. In UPex and LBNPex, submaximal exercise responses were similar pre- and post-bed rest. Our results indicate that a daily 30-min bout of intense, interval upright exercise training or supine exercise training against LBNP is sufficient to maintain upright exercise responses after 5 d of bed rest. These results may have important implications for the development of exercise countermeasures during space flight.

  5. The calibration of photographic and spectroscopic films. A densitometric analysis of IIaO film flown aboard the space shuttle transportation system STS3, STS8, and STS7

    NASA Technical Reports Server (NTRS)

    Hammond, Ernest C., Jr.

    1987-01-01

    The results of these studies have implications for the utilization of the IIaO spectroscopic film on the future shuttle and space lab missions. These responses to standard photonic energy sources will have immediate application for the uneven responses of the film photographing a star field in a terrestrial or extraterrestrial environment with associated digital imaging equipment.

  6. The German ISS-Experiment Cellular Responses to Radiation in Space (CERASP): The Effects of Single and Combined Space Flight Conditions on Mammalian Cells

    NASA Astrophysics Data System (ADS)

    Baumstark-Khan, C.; Hellweg, C. E.; Arenz, A.

    The combined action of ionizing radiation and microgravity will continue to influence future space missions with special risks for astronauts on the Moon surface or for long duration missions to Mars Previous space flight experiments have reported additive neither sensitization nor protection as well as synergistic increased radiation effect under microgravity interactions of radiation and microgravity in different cell systems Although a direct effect of microgravity on enzymatic mechanisms can be excluded on thermo dynamical reasons modifications of cellular repair can not be excluded as such processes are under the control of cellular signal transduction systems which are controlled by environmental parameters presumably also by gravity DNA repair studies in space on bacteria yeast cells and human fibroblasts which were irradiated before flight gave contradictory results from inhibition of repair by microgravity to enhancement whereas others did not detect any influence of microgravity on repair At the Radiation Biology Department of the German Aerospace Center DLR recombinant bacterial and mammalian cell systems were developed as reporters for cellular signal transduction modulation by genotoxic environmental conditions The space experiment CERASP Cellular Responses to Radiation in Space to be performed at the International Space Station ISS will make use of such reporter cell lines thereby supplying basic information on the cellular response to radiation applied in microgravity One of the biological endpoints will be survival

  7. Skylab: A beginning. [astronaut performance in extended space exploration

    NASA Technical Reports Server (NTRS)

    Dietlein, L. F.

    1974-01-01

    Skylab biomedical experience indicates that man adapts well to and functions effectively in the space environment for time periods approaching three months. Appropriate dietary intake coupled with adequate, programmed exercise, sleep, work and recreation periods are essential to crew health and well being. No untoward physiological responses have been noted that would preclude longer duration space flights, but more research is required in order to understand the mechanisms involved in the observed responses. Remedial or preventive measures may be required for Mars-type missions, and further study of man in earth orbit for an uninterrupted six-month period should ideally precede this Mars-type mission.

  8. 14 CFR § 1214.402 - International Space Station crewmember responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false International Space Station crewmember responsibilities. § 1214.402 Section § 1214.402 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT International Space Station Crew § 1214.402 International Space Station crewmember...

  9. System identification for Space Station Freedom using observer/Kalman filter Markov parameters. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Papadopoulos, Michael; Tolson, Robert H.

    1993-01-01

    The Modal Identification Experiment (MIE) is a proposed experiment to define the dynamic characteristics of Space Station Freedom. Previous studies emphasized free-decay modal identification. The feasibility of using a forced response method (Observer/Kalman Filter Identification (OKID)) is addressed. The interest in using OKID is to determine the input mode shape matrix which can be used for controller design or control-structure interaction analysis, and investigate if forced response methods may aid in separating closely spaced modes. A model of the SC-7 configuration of Space Station Freedom was excited using simulated control system thrusters to obtain acceleration output. It is shown that an 'optimum' number of outputs exists for OKID. To recover global mode shapes, a modified method called Global-Local OKID was developed. This study shows that using data from a long forced response followed by free-decay leads to the 'best' modal identification. Twelve out of the thirteen target modes were identified for such an output.

  10. 14 CFR 1214.402 - International Space Station crewmember responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false International Space Station crewmember... SPACE FLIGHT International Space Station Crew § 1214.402 International Space Station crewmember responsibilities. (a) All NASA-provided International Space Station crewmembers are subject to specified standards...

  11. 14 CFR 1214.402 - International Space Station crewmember responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false International Space Station crewmember... SPACE FLIGHT International Space Station Crew § 1214.402 International Space Station crewmember responsibilities. (a) All NASA-provided International Space Station crewmembers are subject to specified standards...

  12. Space Microbiology

    PubMed Central

    Horneck, Gerda; Klaus, David M.; Mancinelli, Rocco L.

    2010-01-01

    Summary: The responses of microorganisms (viruses, bacterial cells, bacterial and fungal spores, and lichens) to selected factors of space (microgravity, galactic cosmic radiation, solar UV radiation, and space vacuum) were determined in space and laboratory simulation experiments. In general, microorganisms tend to thrive in the space flight environment in terms of enhanced growth parameters and a demonstrated ability to proliferate in the presence of normally inhibitory levels of antibiotics. The mechanisms responsible for the observed biological responses, however, are not yet fully understood. A hypothesized interaction of microgravity with radiation-induced DNA repair processes was experimentally refuted. The survival of microorganisms in outer space was investigated to tackle questions on the upper boundary of the biosphere and on the likelihood of interplanetary transport of microorganisms. It was found that extraterrestrial solar UV radiation was the most deleterious factor of space. Among all organisms tested, only lichens (Rhizocarpon geographicum and Xanthoria elegans) maintained full viability after 2 weeks in outer space, whereas all other test systems were inactivated by orders of magnitude. Using optical filters and spores of Bacillus subtilis as a biological UV dosimeter, it was found that the current ozone layer reduces the biological effectiveness of solar UV by 3 orders of magnitude. If shielded against solar UV, spores of B. subtilis were capable of surviving in space for up to 6 years, especially if embedded in clay or meteorite powder (artificial meteorites). The data support the likelihood of interplanetary transfer of microorganisms within meteorites, the so-called lithopanspermia hypothesis. PMID:20197502

  13. Applied Joint-Space Torque and Stiffness Control of Tendon-Driven Fingers

    NASA Technical Reports Server (NTRS)

    Abdallah, Muhammad E.; Platt, Robert, Jr.; Wampler, Charles W.; Hargrave, Brian

    2010-01-01

    Existing tendon-driven fingers have applied force control through independent tension controllers on each tendon, i.e. in the tendon-space. The coupled kinematics of the tendons, however, cause such controllers to exhibit a transient coupling in their response. This problem can be resolved by alternatively framing the controllers in the joint-space of the manipulator. This work presents a joint-space torque control law that demonstrates both a decoupled and significantly faster response than an equivalent tendon-space formulation. The law also demonstrates greater speed and robustness than comparable PI controllers. In addition, a tension distribution algorithm is presented here to allocate forces from the joints to the tendons. It allocates the tensions so that they satisfy both an upper and lower bound, and it does so without requiring linear programming or open-ended iterations. The control law and tension distribution algorithm are implemented on the robotic hand of Robonaut-2.

  14. State-space receptive fields of semicircular canal afferent neurons in the bullfrog

    NASA Technical Reports Server (NTRS)

    Paulin, M. G.; Hoffman, L. F.

    2001-01-01

    Receptive fields are commonly used to describe spatial characteristics of sensory neuron responses. They can be extended to characterize temporal or dynamical aspects by mapping neural responses in dynamical state spaces. The state-space receptive field of a neuron is the probability distribution of the dynamical state of the stimulus-generating system conditioned upon the occurrence of a spike. We have computed state-space receptive fields for semicircular canal afferent neurons in the bullfrog (Rana catesbeiana). We recorded spike times during broad-band Gaussian noise rotational velocity stimuli, computed the frequency distribution of head states at spike times, and normalized these to obtain conditional pdfs for the state. These state-space receptive fields quantify what the brain can deduce about the dynamical state of the head when a single spike arrives from the periphery. c2001 Elsevier Science B.V. All rights reserved.

  15. Primary health care reform, dilemmatic space and risk of burnout among health workers.

    PubMed

    Freeman, Toby; Baum, Fran; Labonté, Ronald; Javanparast, Sara; Lawless, Angela

    2018-05-01

    Health system changes may increase primary health care workers' dilemmatic space, created when reforms contravene professional values. Dilemmatic space may be a risk factor for burnout. This study partnered with six Australian primary health care services (in South Australia: four state government-managed services including one Aboriginal health team and one non-government organisation and in Northern Territory: one Aboriginal community-controlled service) during a period of change and examined workers' dilemmatic space and incidence of burnout. Dilemmatic space and burnout were assessed in a survey of 130 staff across the six services (58% response rate). Additionally, 63 interviews were conducted with practitioners, managers, regional executives and health department staff. Dilemmatic space occurred across all services and was associated with higher rates of self-reported burnout. Three conditions associated with dilemmatic space were (1) conditions inherent in comprehensive primary health care, (2) stemming from service provision for Aboriginal and Torres Strait Islander peoples and (3) changes wrought by reorientation to selective primary health care in South Australia. Responses to dilemmatic space included ignoring directives or doing work 'under the radar', undertaking alternative work congruent with primary health care values outside of hours, or leaving the organisation. The findings show that comprehensive primary health care was contested and political. Future health reform processes would benefit from considering alignment of changes with staff values to reduce negative effects of the reform and safeguard worker wellbeing.

  16. Impact of Conflict Avoidance Responsibility Allocation on Pilot Workload in a Distributed Air Traffic Management System

    NASA Technical Reports Server (NTRS)

    Ligda, Sarah V.; Dao, Arik-Quang V.; Vu, Kim-Phuong; Strybel, Thomas Z.; Battiste, Vernol; Johnson, Walter W.

    2010-01-01

    Pilot workload was examined during simulated flights requiring flight deck-based merging and spacing while avoiding weather. Pilots used flight deck tools to avoid convective weather and space behind a lead aircraft during an arrival into Louisville International airport. Three conflict avoidance management concepts were studied: pilot, controller or automation primarily responsible. A modified Air Traffic Workload Input Technique (ATWIT) metric showed highest workload during the approach phase of flight and lowest during the en-route phase of flight (before deviating for weather). In general, the modified ATWIT was shown to be a valid and reliable workload measure, providing more detailed information than post-run subjective workload metrics. The trend across multiple workload metrics revealed lowest workload when pilots had both conflict alerting and responsibility of the three concepts, while all objective and subjective measures showed highest workload when pilots had no conflict alerting or responsibility. This suggests that pilot workload was not tied primarily to responsibility for resolving conflicts, but to gaining and/or maintaining situation awareness when conflict alerting is unavailable.

  17. Comparison of Controller and Flight Deck Algorithm Performance During Interval Management with Dynamic Arrival Trees (STARS)

    NASA Technical Reports Server (NTRS)

    Battiste, Vernol; Lawton, George; Lachter, Joel; Brandt, Summer; Koteskey, Robert; Dao, Arik-Quang; Kraut, Josh; Ligda, Sarah; Johnson, Walter W.

    2012-01-01

    Managing the interval between arrival aircraft is a major part of the en route and TRACON controller s job. In an effort to reduce controller workload and low altitude vectoring, algorithms have been developed to allow pilots to take responsibility for, achieve and maintain proper spacing. Additionally, algorithms have been developed to create dynamic weather-free arrival routes in the presence of convective weather. In a recent study we examined an algorithm to handle dynamic re-routing in the presence of convective weather and two distinct spacing algorithms. The spacing algorithms originated from different core algorithms; both were enhanced with trajectory intent data for the study. These two algorithms were used simultaneously in a human-in-the-loop (HITL) simulation where pilots performed weather-impacted arrival operations into Louisville International Airport while also performing interval management (IM) on some trials. The controllers retained responsibility for separation and for managing the en route airspace and some trials managing IM. The goal was a stress test of dynamic arrival algorithms with ground and airborne spacing concepts. The flight deck spacing algorithms or controller managed spacing not only had to be robust to the dynamic nature of aircraft re-routing around weather but also had to be compatible with two alternative algorithms for achieving the spacing goal. Flight deck interval management spacing in this simulation provided a clear reduction in controller workload relative to when controllers were responsible for spacing the aircraft. At the same time, spacing was much less variable with the flight deck automated spacing. Even though the approaches taken by the two spacing algorithms to achieve the interval management goals were slightly different they seem to be simpatico in achieving the interval management goal of 130 sec by the TRACON boundary.

  18. Workload capacity spaces: a unified methodology for response time measures of efficiency as workload is varied.

    PubMed

    Townsend, James T; Eidels, Ami

    2011-08-01

    Increasing the number of available sources of information may impair or facilitate performance, depending on the capacity of the processing system. Tests performed on response time distributions are proving to be useful tools in determining the workload capacity (as well as other properties) of cognitive systems. In this article, we develop a framework and relevant mathematical formulae that represent different capacity assays (Miller's race model bound, Grice's bound, and Townsend's capacity coefficient) in the same space. The new space allows a direct comparison between the distinct bounds and the capacity coefficient values and helps explicate the relationships among the different measures. An analogous common space is proposed for the AND paradigm, relating the capacity index to the Colonius-Vorberg bounds. We illustrate the effectiveness of the unified spaces by presenting data from two simulated models (standard parallel, coactive) and a prototypical visual detection experiment. A conversion table for the unified spaces is provided.

  19. 14 CFR 417.7 - Public safety responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Public safety responsibility. 417.7 Section 417.7 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... safety responsibility. A launch operator is responsible for ensuring the safe conduct of a licensed...

  20. 14 CFR 417.7 - Public safety responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Public safety responsibility. 417.7 Section 417.7 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... safety responsibility. A launch operator is responsible for ensuring the safe conduct of a licensed...

  1. Cellular Response to Bleomycin-Induced DNA Damage in Human Fibroblast Cells in Space

    NASA Technical Reports Server (NTRS)

    Lu, Tao; Zhang, Ye; Wong, Michael; Stodieck, Louis; Karouia, Fathi; Wu, Honglu

    2015-01-01

    Outside the protection of the geomagnetic field, astronauts and other living organisms are constantly exposed to space radiation that consists of energetic protons and other heavier charged particles. Whether spaceflight factors, microgravity in particular, have effects on cellular responses to DNA damage induced by exposure to radiation or cytotoxic chemicals is still unknown, as is their impact on the radiation risks for astronauts and on the mutation rate in microorganisms. Although possible synergistic effects of space radiation and other spaceflight factors have been investigated since the early days of the human space program, the published results were mostly conflicting and inconsistent. To investigate effects of spaceflight on cellular responses to DNA damages, human fibroblast cells flown to the International Space Station (ISS) were treated with bleomycin for three hours in the true microgravity environment, which induced DNA damages including double-strand breaks (DSB) similar to the ionizing radiation. Damages in the DNA were measured by the phosphorylation of a histone protein H2AX (g-H2AX), which showed slightly more foci in the cells on ISS than in the ground control. The expression of genes involved in DNA damage response was also analyzed using the PCR array. Although a number of the genes, including CDKN1A and PCNA, were significantly altered in the cells after bleomycin treatment, no significant difference in the expression profile of DNA damage response genes was found between the flight and ground samples. At the time of the bleomycin treatment, the cells on the ISS were found to be proliferating faster than the ground control as measured by the percentage of cells containing positive Ki-67 signals. Our results suggested that the difference in g-H2AX focus counts between flight and ground was due to the faster growth rate of the cells in space, but spaceflight did not affect initial transcriptional responses of the DNA damage response genes to bleomycin treatment.

  2. Cellular Response to Bleomycin-Induced DNA Damage in Human Fibroblast Cells in Space

    NASA Technical Reports Server (NTRS)

    Lu, Tao; Zhang, Ye; Wong, Michael; Stodieck, Louis; Karouia, Fathi; Wu, Honglu

    2015-01-01

    Living organisms are constantly exposed to space radiation that consists of energetic protons and other heavier charged particles. Whether spaceflight factors, microgravity in particular, affects on the cellular response to DNA damage induced by exposures to radiation or other toxic chemicals will have an impact on the radiation risks for the astronauts, as well as on the mutation rate in microorganisms, is still an open question. Although the possible synergistic effects of space radiation and other spaceflight factors have been investigated since the early days of the human space program, the published results were mostly conflicting and inconsistent. To investigate the effects of spaceflight on the cellular response to DNA damages, human fibroblast cells flown to the International Space Station (ISS) were treated with bleomycin for three hours in the true microgravity environment, which induces DNA damages including the double strand breaks (DSB) similar to the ionizing radiation. Damage in the DNA was measured by the phosphorylation of a histone protein H2AX (-H2AX), which showed slightly more foci in the cells on ISS than in the ground control. The expression of genes involved in the DNA damage response was also analyzed using the PCR array. Although a number of the genes, including CDKN1A and PCNA, were significantly altered in the cells after bleomycin treatment, no significant difference in the expression profile of DNA damage response genes was found between the flight and ground samples. At the time of the bleomycin treatment, the cells on the ISS were found to be proliferating faster than the ground control as measured by the percentage of cells containing positive Ti-67 signals. Our results suggested that the difference in -H2AX between flight and ground was due to the faster growth rate of the cells in space, but spaceflight did not affect the response of the DNA damage response genes to bleomycin treatment.

  3. Maximize, minimize or target - optimization for a fitted response from a designed experiment

    DOE PAGES

    Anderson-Cook, Christine Michaela; Cao, Yongtao; Lu, Lu

    2016-04-01

    One of the common goals of running and analyzing a designed experiment is to find a location in the design space that optimizes the response of interest. Depending on the goal of the experiment, we may seek to maximize or minimize the response, or set the process to hit a particular target value. After the designed experiment, a response model is fitted and the optimal settings of the input factors are obtained based on the estimated response model. Furthermore, the suggested optimal settings of the input factors are then used in the production environment.

  4. 22 CFR 62.50 - Sanctions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... exceed 20 pages in length, double-spaced and, if appropriate, may include additional documentary material... decision. Such statement may not exceed 20 pages in length, double-spaced and, if appropriate, may include... mitigation of the proposed sanction, or statement in response thereto, may not exceed 25 pages in length...

  5. 14 CFR 1252.300 - General responsibilities of recipients.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false General responsibilities of recipients. 1252.300 Section 1252.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... Responsibilities of Recipients § 1252.300 General responsibilities of recipients. Each NASA recipient must ensure...

  6. Biomedical and Human Factors Requirements for a Manned Earth Orbiting Station

    NASA Technical Reports Server (NTRS)

    Helvey, W.; Martell, C.; Peters, J.; Rosenthal, G.; Benjamin, F.; Albright, G.

    1964-01-01

    The primary objective of this study is to determine which biomedical and human factors measurements must be made aboard a space station to assure adequate evaluation of the astronaut's health and performance during prolonged space flights. The study has employed, where possible, a medical and engineering systems analysis to define the pertinent life sciences and space station design parameters and their influence on a measurement program. The major areas requiring evaluation in meeting the study objectives include a definition of the space environment, man's response to the environment, selection of measurement and data management techniques, experimental program, space station design requirements, and a trade-off analysis with final recommendations. The space environment factors that are believed to have a significant effect on man were evaluated. This includes those factors characteristic of the space environment (e. g. weightlessness, radiation) as well as those created within the space station (e. g. toxic contaminants, capsule atmosphere). After establishing the general features of the environment, an appraisal was made of the anticipated response of the astronaut to each of these factors. For thoroughness, the major organ systems and functions of the body were delineated, and a determination was made of their anticipated response to each of the environmental categories. A judgment was then made on the medical significance or importance of each response, which enabled a determination of which physiological and psychological effects should be monitored. Concurrently, an extensive list of measurement techniques and methods of data management was evaluated for applicability to the space station program. The various space station configurations and design parameters were defined in terms of the biomedical and human factors requirements to provide the measurements program. Research design of experimental programs for various station configurations, mission durations, and crew sizes were prepared, and, finally, a trade-off analysis of the critical variables in the station planning was completed with recommendations to enhance the confidence in the measurement program.

  7. Assessment of the effects of the zero gravity environment on the health and safety of space workers. Summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1980-02-18

    A review was conducted of currently available information relating to adverse effects to the health and safety that SPS space workers may experience. Currently available information on the responses of humans to space flight is somewhat limited and was obtained under conditions which are grossly different from conditions to be experienced by future space workers. The limitations in information and differences in conditions have been considered in the assessment of potential health and safety hazards to the SPS space workers. The study did not disclose any adverse effects that would result in long term deviations to the medical or physiologicalmore » health of space workers so long as proper preventive or ameleorating actions were taken.« less

  8. Delay time correction of the gas analyzer in the calculation of anatomical dead space of the lung.

    PubMed

    Okubo, T; Shibata, H; Takishima, T

    1983-07-01

    By means of a mathematical model, we have studied a way to correct the delay time of the gas analyzer in order to calculate the anatomical dead space using Fowler's graphical method. The mathematical model was constructed of ten tubes of equal diameter but unequal length, so that the amount of dead space varied from tube to tube; the tubes were emptied sequentially. The gas analyzer responds with a time lag from the input of the gas signal to the beginning of the response, followed by an exponential response output. The single breath expired volume-concentration relationship was examined with three types of expired flow patterns of which were constant, exponential and sinusoidal. The results indicate that the time correction by the lag time plus time constant of the exponential response of the gas analyzer gives an accurate estimation of anatomical dead space. Time correction less inclusive than this, e.g. lag time only or lag time plus 50% response time, gives an overestimation, and a correction larger than this results in underestimation. The magnitude of error is dependent on the flow pattern and flow rate. The time correction in this study is only for the calculation of dead space, as the corrected volume-concentration curves does not coincide with the true curve. Such correction of the output of the gas analyzer is extremely important when one needs to compare the dead spaces of different gas species at a rather faster flow rate.

  9. Audio Spatial Representation Around the Body

    PubMed Central

    Aggius-Vella, Elena; Campus, Claudio; Finocchietti, Sara; Gori, Monica

    2017-01-01

    Studies have found that portions of space around our body are differently coded by our brain. Numerous works have investigated visual and auditory spatial representation, focusing mostly on the spatial representation of stimuli presented at head level, especially in the frontal space. Only few studies have investigated spatial representation around the entire body and its relationship with motor activity. Moreover, it is still not clear whether the space surrounding us is represented as a unitary dimension or whether it is split up into different portions, differently shaped by our senses and motor activity. To clarify these points, we investigated audio localization of dynamic and static sounds at different body levels. In order to understand the role of a motor action in auditory space representation, we asked subjects to localize sounds by pointing with the hand or the foot, or by giving a verbal answer. We found that the audio sound localization was different depending on the body part considered. Moreover, a different pattern of response was observed when subjects were asked to make actions with respect to the verbal responses. These results suggest that the audio space around our body is split in various spatial portions, which are perceived differently: front, back, around chest, and around foot, suggesting that these four areas could be differently modulated by our senses and our actions. PMID:29249999

  10. Small Space Launch: Origins & Challenges

    NASA Astrophysics Data System (ADS)

    Freeman, T.; Delarosa, J.

    2010-09-01

    The United States Space Situational Awareness capability continues to be a key element in obtaining and maintaining the high ground in space. Space Situational Awareness satellites are critical enablers for integrated air, ground and sea operations, and play an essential role in fighting and winning conflicts. The United States leads the world space community in spacecraft payload systems from the component level into spacecraft, and in the development of constellations of spacecraft. In the area of launch systems that support Space Situational Awareness, despite the recent development of small launch vehicles, the United States launch capability is dominated by an old, unresponsive and relatively expensive set of launchers in the Expandable, Expendable Launch Vehicles (EELV) platforms; Delta IV and Atlas V. The United States directed Air Force Space Command to develop the capability for operationally responsive access to space and use of space to support national security, including the ability to provide critical space capabilities in the event of a failure of launch or on-orbit capabilities. On 1 Aug 06, Air Force Space Command activated the Space Development & Test Wing (SDTW) to perform development, test and evaluation of Air Force space systems and to execute advanced space deployment and demonstration projects to exploit new concepts and technologies, and rapidly migrate capabilities to the warfighter. The SDTW charged the Launch Test Squadron (LTS) with the mission to develop the capability of small space launch, supporting government research and development space launches and missile defense target missions, with operationally responsive spacelift for Low-Earth-Orbit Space Situational Awareness assets as a future mission. This new mission created new challenges for LTS. The LTS mission tenets of developing space launches and missile defense target vehicles were an evolution from the squadrons previous mission of providing sounding rockets under the Rocket Sounding Launch Program (RSLP). The new mission tenets include shortened operational response periods criteria for the warfighter, while reducing the life-cycle development, production and launch costs of space launch systems. This presentation will focus on the technical challenges in transforming and integrating space launch vehicles and space craft vehicles for small space launch missions.

  11. Co-op Essay - Tour 1

    NASA Technical Reports Server (NTRS)

    Porter, Derrick

    2014-01-01

    The Mission Operations Directorate (MOD) is responsible for the training, planning and performance of all U.S. manned operations in space. Within this directorate all responsibilities are divided up into divisions. The EVA, Robotics & Crew Systems Operations Division performs ground operations and trains astronauts to carry out some of the more "high action" procedures in space. For example they orchestrate procedures like EVAs, or ExtraVehicular Activities (spacewalks), and robotics operations external to the International Space Station (ISS). The robotics branch of this division is responsible for the use of the Mobile Servicing System (MSS). This system is a combination of two robotic mechanisms and a series of equipment used to transport them on the ISS. The MSS is used to capture and position visiting vehicles, transport astronauts during EVAs, and perform external maintenance tasks on the ISS. This branch consists of two groups which are responsible for crew training and flight controlling, respectively. My first co-op tour took place Fall 2013. During this time I was given the opportunity to work in the robotics operations branch of the Mission Operations Directorate at NASA's Johnson Space Center. I was given a variety of tasks that encompassed, at a base level, all the aspects of the branch.

  12. Aesthetic Response and Cosmic Aesthetic Distance

    NASA Astrophysics Data System (ADS)

    Madacsi, D.

    2013-04-01

    For Homo sapiens, the experience of a primal aesthetic response to nature was perhaps a necessary precursor to the arousal of an artistic impulse. Among the likely visual candidates for primal initiators of aesthetic response, arguments can be made in favor of the flower, the human face and form, and the sky and light itself as primordial aesthetic stimulants. Although visual perception of the sensory world of flowers and human faces and forms is mediated by light, it was most certainly in the sky that humans first could respond to the beauty of light per se. It is clear that as a species we do not yet identify and comprehend as nature, or part of nature, the entire universe beyond our terrestrial environs, the universe from which we remain inexorably separated by space and time. However, we now enjoy a technologically-enabled opportunity to probe the ultimate limits of visual aesthetic distance and the origins of human aesthetic response as we remotely explore deep space via the Hubble Space Telescope and its successors.

  13. Space Radiation and Manned Mission: Interface Between Physics and Biology

    NASA Astrophysics Data System (ADS)

    Hei, Tom

    2012-07-01

    The natural radiation environment in space consists of a mixed field of high energy protons, heavy ions, electrons and alpha particles. Interplanetary travel to the International Space Station and any planned establishment of satellite colonies on other solar system implies radiation exposure to the crew and is a major concern to space agencies. With shielding, the radiation exposure level in manned space missions is likely to be chronic, low dose irradiation. Traditionally, our knowledge of biological effects of cosmic radiation in deep space is almost exclusively derived from ground-based accelerator experiments with heavy ions in animal or in vitro models. Radiobiological effects of low doses of ionizing radiation are subjected to modulations by various parameters including bystander effects, adaptive response, genomic instability and genetic susceptibility of the exposed individuals. Radiation dosimetry and modeling will provide conformational input in areas where data are difficult to acquire experimentally. However, modeling is only as good as the quality of input data. This lecture will discuss the interdependent nature of physics and biology in assessing the radiobiological response to space radiation.

  14. A linear chromatic mechanism drives the pupillary response.

    PubMed Central

    Tsujimura, S.; Wolffsohn, J. S.; Gilmartin, B.

    2001-01-01

    Previous studies have shown that a chromatic mechanism can drive pupil responses. The aim of this research was to clarify whether a linear or nonlinear chromatic mechanism drives pupillary responses by using test stimuli of various colours that are defined in cone contrast space. The pupil and accommodation responses evoked by these test stimuli were continuously and simultaneously objectively measured by photorefraction. The results with isochromatic and isoluminant stimuli showed that the accommodative level remained approximately constant (< 0.25 D change in mean level) even when the concurrent pupillary response was large (ca. 0.30 mm). The pupillary response to an isoluminant grating was sustained, delayed (by ca. 60 ms) and larger in amplitude than that for a isochromatic uniform stimulus, which supports previous work suggesting that the chromatic mechanism contributes to the pupillary response. In a second experiment, selected chromatic test gratings were used and isoresponse contours in cone contrast space were obtained. The results showed that the isoresponse contour in cone contrast space is well described (r(2) = 0.99) by a straight line with a positive slope. The results indicate that a /L - M/ linear chromatic mechanism, whereby a signal from the long wavelength cone is subtracted from that of the middle wavelength cone and vice versa, drives pupillary responses. PMID:11674867

  15. Reading sentences describing high- or low-pitched auditory events: only pianists show evidence for a horizontal space-pitch association.

    PubMed

    Wolter, Sibylla; Dudschig, Carolin; Kaup, Barbara

    2017-11-01

    This study explored differences between pianists and non-musicians during reading of sentences describing high- or low-pitched auditory events. Based on the embodied model of language comprehension, it was hypothesized that the experience of playing the piano encourages a corresponding association between high-pitched sounds and the right and low-pitched sounds and the left. This pitch-space association is assumed to become elicited during understanding of sentences describing either a high- or low-pitched auditory event. In this study, pianists and non-musicians were tested based on the hypothesis that only pianists show a compatibility effect between implied pitch height and horizontal space, because only pianists have the corresponding experience with the piano keyboard. Participants read pitch-related sentences (e.g., the bear growls deeply, the soprano singer sings an aria) and judged whether the sentence was sensible or not by pressing either a left or right response key. The results indicated that only the pianists showed the predicted compatibility effect between implied pitch height and response location. Based on the results, it can be inferred that the experience of playing the piano led to an association between horizontal space and pitch height in pianists, while no such spatial association was elicited in non-musicians.

  16. Phase space flows for non-Hamiltonian systems with constraints

    NASA Astrophysics Data System (ADS)

    Sergi, Alessandro

    2005-09-01

    In this paper, non-Hamiltonian systems with holonomic constraints are treated by a generalization of Dirac’s formalism. Non-Hamiltonian phase space flows can be described by generalized antisymmetric brackets or by general Liouville operators which cannot be derived from brackets. Both situations are treated. In the first case, a Nosé-Dirac bracket is introduced as an example. In the second one, Dirac’s recipe for projecting out constrained variables from time translation operators is generalized and then applied to non-Hamiltonian linear response. Dirac’s formalism avoids spurious terms in the response function of constrained systems. However, corrections coming from phase space measure must be considered for general perturbations.

  17. Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review.

    PubMed

    Reichmann, W M; Maillefert, J F; Hunter, D J; Katz, J N; Conaghan, P G; Losina, E

    2011-05-01

    The goal of this systematic review was to report the responsiveness to change and reliability of conventional radiographic joint space width (JSW) measurement. We searched the PubMed and Embase databases using the following search criteria: [osteoarthritis (OA) (MeSH)] AND (knee) AND (X-ray OR radiography OR diagnostic imaging OR radiology OR disease progression) AND (joint space OR JSW or disease progression). We assessed responsiveness by calculating the standardized response mean (SRM). We assessed reliability using intra- and inter-reader intra-class correlation (ICC) and coefficient of variation (CV). Random-effects models were used to pool results from multiple studies. Results were stratified by study duration, design, techniques of obtaining radiographs, and measurement method. We identified 998 articles using the search terms. Of these, 32 articles (43 estimates) reported data on responsiveness of JSW measurement and 24 (50 estimates) articles reported data on measures of reliability. The overall pooled SRM was 0.33 [95% confidence interval (CI): 0.26, 0.41]. Responsiveness of change in JSW measurement was improved substantially in studies of greater than 2 years duration (0.57). Further stratifying this result in studies of greater than 2 years duration, radiographs obtained with the knee in a flexed position yielded an SRM of 0.71. Pooled intra-reader ICC was estimated at 0.97 (95% CI: 0.92, 1.00) and the intra-reader CV estimated at 3.0 (95% CI: 2.0, 4.0). Pooled inter-reader ICC was estimated at 0.93 (95% CI: 0.86, 0.99) and the inter-reader CV estimated at 3.4% (95% CI: 1.3%, 5.5%). Measurement of JSW obtained from radiographs in persons with knee is reliable. These data will be useful to clinicians who are planning RCTs where the change in minimum JSW is the outcome of interest. Copyright © 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  18. Quantum-field-theoretical approach to phase-space techniques: Generalizing the positive-P representation

    NASA Astrophysics Data System (ADS)

    Plimak, L. I.; Fleischhauer, M.; Olsen, M. K.; Collett, M. J.

    2003-01-01

    We present an introduction to phase-space techniques (PST) based on a quantum-field-theoretical (QFT) approach. In addition to bridging the gap between PST and QFT, our approach results in a number of generalizations of the PST. First, for problems where the usual PST do not result in a genuine Fokker-Planck equation (even after phase-space doubling) and hence fail to produce a stochastic differential equation (SDE), we show how the system in question may be approximated via stochastic difference equations (SΔE). Second, we show that introducing sources into the SDE’s (or SΔE’s) generalizes them to a full quantum nonlinear stochastic response problem (thus generalizing Kubo’s linear reaction theory to a quantum nonlinear stochastic response theory). Third, we establish general relations linking quantum response properties of the system in question to averages of operator products ordered in a way different from time normal. This extends PST to a much wider assemblage of operator products than are usually considered in phase-space approaches. In all cases, our approach yields a very simple and straightforward way of deriving stochastic equations in phase space.

  19. 14 CFR 437.41 - Mishap response plan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Mishap response plan. 437.41 Section 437.41 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.41 Mishap response plan. An applicant must provide a mishap response plan that meets the...

  20. 14 CFR 437.41 - Mishap response plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Mishap response plan. 437.41 Section 437.41 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.41 Mishap response plan. An applicant must provide a mishap response plan that meets the...

  1. 14 CFR 437.41 - Mishap response plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Mishap response plan. 437.41 Section 437.41 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.41 Mishap response plan. An applicant must provide a mishap response plan that meets the...

  2. 14 CFR 437.41 - Mishap response plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Mishap response plan. 437.41 Section 437.41 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.41 Mishap response plan. An applicant must provide a mishap response plan that meets the...

  3. 14 CFR 437.41 - Mishap response plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Mishap response plan. 437.41 Section 437.41 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.41 Mishap response plan. An applicant must provide a mishap response plan that meets the...

  4. Neural Correlates of Personal Space Intrusion

    PubMed Central

    Cassidy, Brittany S.; Yue, Xiaomin; Rauch, Scott L.; Boeke, Emily A.; Nasr, Shahin; Tootell, Roger B. H.; Coombs, Garth

    2014-01-01

    A parietal-frontal network in primates is thought to support many behaviors occurring in the space around the body, including interpersonal interactions and maintenance of a particular “comfort zone” or distance from other people (“personal space”). To better understand this network in humans, we used functional MRI to measure the responses to moving objects (faces, cars, simple spheres) and the functional connectivity of two regions in this network, the dorsal intraparietal sulcus (DIPS) and the ventral premotor cortex (PMv). We found that both areas responded more strongly to faces that were moving toward (vs away from) subjects, but did not show this bias in response to comparable motion in control stimuli (cars or spheres). Moreover, these two regions were functionally interconnected. Tests of activity-behavior associations revealed that the strength of DIPS-PMv connectivity was correlated with the preferred distance that subjects chose to stand from an unfamiliar person (personal space size). In addition, the magnitude of DIPS and PMv responses was correlated with the preferred level of social activity. Together, these findings suggest that this parietal-frontal network plays a role in everyday interactions with others. PMID:24647934

  5. Long-term survival of bacterial spores in space

    NASA Technical Reports Server (NTRS)

    Horneck, G.; Bucker, H.; Reitz, G.

    1994-01-01

    On board of the NASA Long Duration Exposure Facility (LDEF), spores of Bacillus subtilis in monolayers (10(exp 6)/sample) or multilayers (10(exp 8)/sample) were exposed to the space environment for nearly six years and their survival was analyzed after retrieval. The response to space parameters, such as vacuum (10(exp -6) Pa), solar electromagnetic radiation up to the highly energetic vacuum-ultraviolet range 10(exp 9) J/sq m) and/or cosmic radiation (4.8 Gy), was studied and compared to the results of a simultaneously running ground control experiment. If shielded against solar ultraviolet (UV)-radiation, up to 80% of spores in multilayers survive in space. Solar UV-radiation, being the most deleterious parameter of space, reduces survival by 4 orders of magnitude or more. However, up to 10(exp 4) viable spores were still recovered, even in completely unprotected samples. Substances, such as glucose or buffer salts serve as chemical protectants. With this 6 year study in space, experimental data are provided to the discussion on the likelihood of 'Panspermia'.

  6. Microgravity Induces Changes in Microsome-Associated Proteins of Arabidopsis Seedlings Grown on Board the International Space Station

    PubMed Central

    Grat, Sabine; Pichereaux, Carole; Rossignol, Michel; Pereda-Loth, Veronica; Eche, Brigitte; Boucheron-Dubuisson, Elodie; Le Disquet, Isabel; Medina, Francisco Javier; Graziana, Annick; Carnero-Diaz, Eugénie

    2014-01-01

    The “GENARA A” experiment was designed to monitor global changes in the proteome of membranes of Arabidopsis thaliana seedlings subjected to microgravity on board the International Space Station (ISS). For this purpose, 12-day-old seedlings were grown either in space, in the European Modular Cultivation System (EMCS) under microgravity or on a 1 g centrifuge, or on the ground. Proteins associated to membranes were selectively extracted from microsomes and identified and quantified through LC-MS-MS using a label-free method. Among the 1484 proteins identified and quantified in the 3 conditions mentioned above, 80 membrane-associated proteins were significantly more abundant in seedlings grown under microgravity in space than under 1 g (space and ground) and 69 were less abundant. Clustering of these proteins according to their predicted function indicates that proteins associated to auxin metabolism and trafficking were depleted in the microsomal fraction in µg space conditions, whereas proteins associated to stress responses, defence and metabolism were more abundant in µg than in 1 g indicating that microgravity is perceived by plants as a stressful environment. These results clearly indicate that a global membrane proteomics approach gives a snapshot of the cell status and its signaling activity in response to microgravity and highlight the major processes affected. PMID:24618597

  7. Microgravity induces changes in microsome-associated proteins of Arabidopsis seedlings grown on board the international space station.

    PubMed

    Mazars, Christian; Brière, Christian; Grat, Sabine; Pichereaux, Carole; Rossignol, Michel; Pereda-Loth, Veronica; Eche, Brigitte; Boucheron-Dubuisson, Elodie; Le Disquet, Isabel; Medina, Francisco Javier; Graziana, Annick; Carnero-Diaz, Eugénie

    2014-01-01

    The "GENARA A" experiment was designed to monitor global changes in the proteome of membranes of Arabidopsis thaliana seedlings subjected to microgravity on board the International Space Station (ISS). For this purpose, 12-day-old seedlings were grown either in space, in the European Modular Cultivation System (EMCS) under microgravity or on a 1 g centrifuge, or on the ground. Proteins associated to membranes were selectively extracted from microsomes and identified and quantified through LC-MS-MS using a label-free method. Among the 1484 proteins identified and quantified in the 3 conditions mentioned above, 80 membrane-associated proteins were significantly more abundant in seedlings grown under microgravity in space than under 1 g (space and ground) and 69 were less abundant. Clustering of these proteins according to their predicted function indicates that proteins associated to auxin metabolism and trafficking were depleted in the microsomal fraction in µg space conditions, whereas proteins associated to stress responses, defence and metabolism were more abundant in µg than in 1 g indicating that microgravity is perceived by plants as a stressful environment. These results clearly indicate that a global membrane proteomics approach gives a snapshot of the cell status and its signaling activity in response to microgravity and highlight the major processes affected.

  8. Living in a Flexible Space

    NASA Astrophysics Data System (ADS)

    Canepa, Simona

    2017-10-01

    How long does a space or an object have to last? If in the past an object or a building manufacturing was designed to last as much as possible, nowadays it is designed to have a life related to the time in which it will be used. Flexibility is what characterizes a space, it’s the ability to be variable and adaptable to changes in the lives of users or in relation to the use which these will make over time. The evolution of the labour market, the difficulty of inserting within it and the need to push more and more frequent move today in the trial of living space models increasingly flexible: people, especially young people, are forced to move on territory outlining a new condition to which the flexible nomadic dwellings offer an adequate response, ensuring high functional performance in confined spaces.

  9. Space Weather Effects Produced by the Ring Current Particles

    NASA Astrophysics Data System (ADS)

    Ganushkina, Natalia; Jaynes, Allison; Liemohn, Michael

    2017-11-01

    One of the definitions of space weather describes it as the time-varying space environment that may be hazardous to technological systems in space and/or on the ground and/or endanger human health or life. The ring current has its contributions to space weather effects, both in terms of particles, ions and electrons, which constitute it, and magnetic and electric fields produced and modified by it at the ground and in space. We address the main aspects of the space weather effects from the ring current starting with brief review of ring current discovery and physical processes and the Dst-index and predictions of the ring current and storm occurrence based on it. Special attention is paid to the effects on satellites produced by the ring current electrons. The ring current is responsible for several processes in the other inner magnetosphere populations, such as the plasmasphere and radiation belts which is also described. Finally, we discuss the ring current influence on the ionosphere and the generation of geomagnetically induced currents (GIC).

  10. A "Kanes's Dynamics" Model for the Active Rack Isolation System

    NASA Technical Reports Server (NTRS)

    Hampton, R. David; Beech, Geoffrey

    1999-01-01

    Many microgravity space-science experiments require vibratory acceleration levels unachievable without active isolation. The Boeing Corporation's Active Rack Isolation System (ARIS) employs a novel combination of magnetic actuation and mechanical linkages, to address these isolation requirements on the International Space Station (ISS). ARIS provides isolation at the rack (international Standard Payload Rack, or ISPR) level. Effective model-based vibration isolation requires (1) an appropriate isolation device, (2) an adequate dynamic (i.e., mathematical) model of that isolator, and (3) a suitable, corresponding controller. ARIS provides the ISS response to the first requirement. This paper presents one response to the second, in a state-space framework intended to facilitate an optimal-controls approach to the third. The authors use "Kane's Dynamics" to develop an state-space, analytical (algebraic) set of linearized equations of motion for ARIS.

  11. Space radiation effects on plant and mammalian cells

    NASA Astrophysics Data System (ADS)

    Arena, C.; De Micco, V.; Macaeva, E.; Quintens, R.

    2014-11-01

    The study of the effects of ionizing radiation on organisms is related to different research aims. The current review emphasizes the studies on the effects of different doses of sparsely and densely ionizing radiation on living organisms, with the final purpose of highlighting specific and common effects of space radiation in mammals and plants. This topic is extremely relevant in the context of radiation protection from space environment. The response of different organisms to ionizing radiation depends on the radiation quality/dose and/or the intrinsic characteristics of the living system. Macromolecules, in particular DNA, are the critical targets of radiation, even if there is a strong difference between damages encountered by plant and mammalian cells. The differences in structure and metabolism between the two cell types are responsible for the higher resistance of the plant cell compared with its animal counterpart. In this review, we report some recent findings from studies performed in Space or on Earth, simulating space-like levels of radiation with ground-based facilities, to understand the effect of ionizing radiation on mammalian and plant cells. In particular, our attention is focused on genetic alterations and repair mechanisms in mammalian cells and on structures and mechanisms conferring radioresistance to plant cells.

  12. 14 CFR 1259.501 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Responsibilities. 1259.501 Section 1259.501 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND... and geographical distribution. ...

  13. 14 CFR 1259.501 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Responsibilities. 1259.501 Section 1259.501 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND... and geographical distribution. ...

  14. 14 CFR 1259.501 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Responsibilities. 1259.501 Section 1259.501 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND... and geographical distribution. ...

  15. 14 CFR 1259.501 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Responsibilities. 1259.501 Section 1259.501 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND... and geographical distribution. ...

  16. Familiarity expands space and contracts time.

    PubMed

    Jafarpour, Anna; Spiers, Hugo

    2017-01-01

    When humans draw maps, or make judgments about travel-time, their responses are rarely accurate and are often systematically distorted. Distortion effects on estimating time to arrival and the scale of sketch-maps reveal the nature of mental representation of time and space. Inspired by data from rodent entorhinal grid cells, we predicted that familiarity to an environment would distort representations of the space by expanding the size of it. We also hypothesized that travel-time estimation would be distorted in the same direction as space-size, if time and space rely on the same cognitive map. We asked international students, who had lived at a college in London for 9 months, to sketch a south-up map of their college district, estimate travel-time to destinations within the area, and mark their everyday walking routes. We found that while estimates for sketched space were expanded with familiarity, estimates of the time to travel through the space were contracted with familiarity. Thus, we found dissociable responses to familiarity in representations of time and space. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.

  17. Evidence Report: Risk of Crew Adverse Health Event Due to Altered Immune Response

    NASA Technical Reports Server (NTRS)

    Crucian, Brian; Sams, Clarence F.

    2013-01-01

    The Risk of Crew Adverse Health Event Due to Altered Immune Response is identified by the National Aeronautics and Space Administration (NASA) Human Research Program (HRP) as a recognized risk to human health and performance in space. The HRP Program Requirements Document (PRD) defines these risks. This Evidence Report provides a summary of the evidence that has been used to identify and characterize this risk. It is known that human immune function is altered in- and post-flight, but it is unclear at present if such alterations lead to increased susceptibility to disease. Reactivation of latent viruses has been documented in crewmembers, although this reactivation has not been directly correlated with immune changes or with observed diseases. As described in this report, further research is required to better characterize the relationships between altered immune response and susceptibility to disease during and after spaceflight. This is particularly important for future deep-space exploration missions.

  18. 14 CFR 1214.305 - Payload specialist responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Payload specialist responsibilities. 1214.305 Section 1214.305 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Payload Specialists for Space Transportation System (STS) Missions § 1214.305 Payload specialist...

  19. 14 CFR 1214.305 - Payload specialist responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Payload specialist responsibilities. 1214.305 Section 1214.305 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Payload Specialists for Space Transportation System (STS) Missions § 1214.305 Payload specialist...

  20. 14 CFR 1214.305 - Payload specialist responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Payload specialist responsibilities. 1214.305 Section 1214.305 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Payload Specialists for Space Transportation System (STS) Missions § 1214.305 Payload specialist...

  1. 14 CFR 1214.305 - Payload specialist responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Payload specialist responsibilities. 1214.305 Section 1214.305 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Payload Specialists for Space Transportation System (STS) Missions § 1214.305 Payload specialist...

  2. Preparation and Current Situation of Proton-ICCHIBAN-2 Experiment

    NASA Astrophysics Data System (ADS)

    Uchihori, Yukio; Yasuda, Nakahiro; Kitamura, H.; Kodaira, S.; Benton, Eric; Hajek, Michael; Berger, Thomas; Jadrnickova, Iva; Ploc, Ondrej

    The ICCHIBAN (Inter Comparison for Cosmicrays with Heavy Ion Beams at NIRS) working group has organized and performed various ICCHIBAN runs for active and passive radiation detectors at HIMAC, NIRS, Japan, Loma Linda and Brookhaven, USA and CERN, Switzer-land since the start of the ICCHIBAN project in the year 2002. One of the main focus points of this project is to understand the response of the applied detector systems (either active or passive) for personal and area dosimetry in space environment to a simulated sub-set of the space radiation environment, focusing on the heavy ion response. This is of special importance for the further intercomparison of space radiation data gathered by various international in-stitutes and universities for space radiation experiments as MATROSHKA, DOSIS, DOBIES, BRADOS, MATROSHKA-R etc. The ICCHIBAN experiments have created a big database of response data, especially for all the different passive radiation detectors and detector materials (Thermoluminescence (TLD) and Optical Luminescence (OSL)) over the last 7 years, resulting in a better understanding of how and why we still have differences in the measurement results from common space experiments -as the Space ICCHIBAN 2 experiment. One of the reasons why for the differences in the TLD/OSL results is the lack of intercomparison and response data for low LET particles up to around 10 keV/m, especially protons. Due to the fact, that the main contribution to absorbed dose in low earth orbit is due to protons, the ICCHIBAN working group has started the set-up of a Proton ICCHIBAN intercomparison experiment at NIRS. The Proton ICCHIBAN run has been performed at the cyclotron at NIRS, Chiba in February 2010. 15 institutes from 12 countries sent or brought their dosimeters and exposed them to 40 and 70 MeV proton beams with the same doses and exposure conditions. In this paper, the experiment procedures and current situation of the intercomparision experiments will be shown.

  3. Imitate or innovate: Competition of strategy updating attitudes in spatial social dilemma games

    NASA Astrophysics Data System (ADS)

    Danku, Zsuzsa; Wang, Zhen; Szolnoki, Attila

    2018-01-01

    Evolution is based on the assumption that competing players update their strategies to increase their individual payoffs. However, while the applied updating method can be different, most of previous works proposed uniform models where players use identical way to revise their strategies. In this work we explore how imitation-based or learning attitude and innovation-based or myopic best-response attitude compete for space in a complex model where both attitudes are available. In the absence of additional cost the best response trait practically dominates the whole snow-drift game parameter space which is in agreement with the average payoff difference of basic models. When additional cost is involved then the imitation attitude can gradually invade the whole parameter space but this transition happens in a highly nontrivial way. However, the role of competing attitudes is reversed in the stag-hunt parameter space where imitation is more successful in general. Interestingly, a four-state solution can be observed for the latter game which is a consequence of an emerging cyclic dominance between possible states. These phenomena can be understood by analyzing the microscopic invasion processes, which reveals the unequal propagation velocities of strategies and attitudes.

  4. KSC-03PD-3134

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. Dignitaries, invited guests, space center employees, and the media gather for a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  5. KSC-03PD-3132

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. Dignitaries, invited guests, space center employees, and the media gather for a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  6. KSC-03PD-3136

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. Capt. Winston Scott, executive director of the Florida Space Authority, speaks at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  7. Econazole-releasing porous space maintainers for fungal periprosthetic joint infection.

    PubMed

    Tatara, Alexander M; Rozich, Allison J; Kontoyiannis, Panayiotis D; Watson, Emma; Albert, Nathaniel D; Bennett, George N; Mikos, Antonios G

    2018-05-11

    While antibiotic-eluting polymethylmethacrylate space maintainers have shown efficacy in the treatment of bacterial periprosthetic joint infection and osteomyelitis, antifungal-eluting space maintainers are associated with greater limitations for treatment of fungal musculoskeletal infections including limited elution concentration and duration. In this study, we have designed a porous econazole-eluting space maintainer capable of greater inhibition of fungal growth than traditional solid space maintainers. The eluted econazole demonstrated bioactivity in a concentration-dependent manner against the most common species responsible for fungal periprosthetic joint infection as well as staphylococci. Lastly, these porous space maintainers retain compressive mechanical properties appropriate to maintain space before definitive repair of the joint or bony defect.

  8. 14 CFR § 1216.311 - Emergency responses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... would collect extraterrestrial materials from solar system bodies and return them to Earth. 3. NASA Senior Environmental Official—The Senior NASA Headquarters Official responsible for providing executive... Projects/Programs—Those NASA actions that develop products intended for use in space and/or that support...

  9. 24 CFR 891.400 - Responsibilities of owner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DISABILITIES PROGRAM) SUPPORTIVE HOUSING FOR THE ELDERLY AND PERSONS WITH DISABILITIES Project Management § 891... unleased units or residential spaces. (b) Management and maintenance. The Owner is responsible for all management functions. These functions include selection and admission of tenants, required reexaminations of...

  10. 24 CFR 891.400 - Responsibilities of owner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DISABILITIES PROGRAM) SUPPORTIVE HOUSING FOR THE ELDERLY AND PERSONS WITH DISABILITIES Project Management § 891... unleased units or residential spaces. (b) Management and maintenance. The Owner is responsible for all management functions. These functions include selection and admission of tenants, required reexaminations of...

  11. 41 CFR 301-70.902 - Do we have any special responsibilities related to space available travel on our Government...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... responsibilities related to space available travel on our Government aircraft? 301-70.902 Section 301-70.902 Public... responsibilities related to space available travel on our Government aircraft? Yes, except for travel authorized... for official travel. You must also certify that carrying a passenger in space available does not cause...

  12. 41 CFR 301-70.902 - Do we have any special responsibilities related to space available travel on our Government...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... responsibilities related to space available travel on our Government aircraft? 301-70.902 Section 301-70.902 Public... responsibilities related to space available travel on our Government aircraft? Yes, except for travel authorized... for official travel. You must also certify that carrying a passenger in space available does not cause...

  13. 41 CFR 301-70.902 - Do we have any special responsibilities related to space available travel on our Government...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... responsibilities related to space available travel on our Government aircraft? 301-70.902 Section 301-70.902 Public... responsibilities related to space available travel on our Government aircraft? Yes, except for travel authorized... for official travel. You must also certify that carrying a passenger in space available does not cause...

  14. 41 CFR 301-70.902 - Do we have any special responsibilities related to space available travel on our Government...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... responsibilities related to space available travel on our Government aircraft? 301-70.902 Section 301-70.902 Public... responsibilities related to space available travel on our Government aircraft? Yes, except for travel authorized... for official travel. You must also certify that carrying a passenger in space available does not cause...

  15. 41 CFR 301-70.902 - Do we have any special responsibilities related to space available travel on our Government...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... responsibilities related to space available travel on our Government aircraft? 301-70.902 Section 301-70.902 Public... responsibilities related to space available travel on our Government aircraft? Yes, except for travel authorized... for official travel. You must also certify that carrying a passenger in space available does not cause...

  16. NASA Headquarters Space Operations Center: Providing Situational Awareness for Spaceflight Contingency Response

    NASA Technical Reports Server (NTRS)

    Maxwell, Theresa G.; Bihner, William J.

    2010-01-01

    This paper discusses the NASA Headquarters mishap response process for the Space Shuttle and International Space Station programs, and how the process has evolved based on lessons learned from the Space Shuttle Challenger and Columbia accidents. It also describes the NASA Headquarters Space Operations Center (SOC) and its special role in facilitating senior management's overall situational awareness of critical spaceflight operations, before, during, and after a mishap, to ensure a timely and effective contingency response.

  17. Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences

    PubMed Central

    Zhang, Ye; Moreno-Villanueva, Maria; Krieger, Stephanie; Ramesh, Govindarajan T.; Neelam, Srujana; Wu, Honglu

    2017-01-01

    In space, living organisms are exposed to multiple stress factors including microgravity and space radiation. For humans, these harmful environmental factors have been known to cause negative health impacts such as bone loss and immune dysfunction. Understanding the mechanisms by which spaceflight impacts human health at the molecular level is critical not only for accurately assessing the risks associated with spaceflight, but also for developing effective countermeasures. Over the years, a number of studies have been conducted under real or simulated space conditions. RNA and protein levels in cellular and animal models have been targeted in order to identify pathways affected by spaceflight. Of the many pathways responsive to the space environment, the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) network appears to commonly be affected across many different cell types under the true or simulated spaceflight conditions. NF-κB is of particular interest, as it is associated with many of the spaceflight-related health consequences. This review intends to summarize the transcriptomics studies that identified NF-κB as a responsive pathway to ground-based simulated microgravity or the true spaceflight condition. These studies were carried out using either human cell or animal models. In addition, the review summarizes the studies that focused specifically on NF-κB pathway in specific cell types or organ tissues as related to the known spaceflight-related health risks including immune dysfunction, bone loss, muscle atrophy, central nerve system (CNS) dysfunction, and risks associated with space radiation. Whether the NF-κB pathway is activated or inhibited in space is dependent on the cell type, but the potential health impact appeared to be always negative. It is argued that more studies on NF-κB should be conducted to fully understand this particular pathway for the benefit of crew health in space. PMID:28561779

  18. Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences.

    PubMed

    Zhang, Ye; Moreno-Villanueva, Maria; Krieger, Stephanie; Ramesh, Govindarajan T; Neelam, Srujana; Wu, Honglu

    2017-05-31

    In space, living organisms are exposed to multiple stress factors including microgravity and space radiation. For humans, these harmful environmental factors have been known to cause negative health impacts such as bone loss and immune dysfunction. Understanding the mechanisms by which spaceflight impacts human health at the molecular level is critical not only for accurately assessing the risks associated with spaceflight, but also for developing effective countermeasures. Over the years, a number of studies have been conducted under real or simulated space conditions. RNA and protein levels in cellular and animal models have been targeted in order to identify pathways affected by spaceflight. Of the many pathways responsive to the space environment, the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) network appears to commonly be affected across many different cell types under the true or simulated spaceflight conditions. NF-κB is of particular interest, as it is associated with many of the spaceflight-related health consequences. This review intends to summarize the transcriptomics studies that identified NF-κB as a responsive pathway to ground-based simulated microgravity or the true spaceflight condition. These studies were carried out using either human cell or animal models. In addition, the review summarizes the studies that focused specifically on NF-κB pathway in specific cell types or organ tissues as related to the known spaceflight-related health risks including immune dysfunction, bone loss, muscle atrophy, central nerve system (CNS) dysfunction, and risks associated with space radiation. Whether the NF-κB pathway is activated or inhibited in space is dependent on the cell type, but the potential health impact appeared to be always negative. It is argued that more studies on NF-κB should be conducted to fully understand this particular pathway for the benefit of crew health in space.

  19. 10 CFR Appendix E to Part 50 - Emergency Planning and Preparedness for Production and Utilization Facilities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... organization shall be described. The communication steps to be taken to alert or activate emergency personnel... operations facility must include the following: (1) Space for members of an NRC site team and Federal, State, and local responders; (2) Additional space for conducting briefings with emergency response personnel...

  20. 10 CFR Appendix E to Part 50 - Emergency Planning and Preparedness for Production and Utilization Facilities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... organization shall be described. The communication steps to be taken to alert or activate emergency personnel... operations facility must include the following: (1) Space for members of an NRC site team and Federal, State, and local responders; (2) Additional space for conducting briefings with emergency response personnel...

  1. 10 CFR Appendix E to Part 50 - Emergency Planning and Preparedness for Production and Utilization Facilities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... organization shall be described. The communication steps to be taken to alert or activate emergency personnel... operations facility must include the following: (1) Space for members of an NRC site team and Federal, State, and local responders; (2) Additional space for conducting briefings with emergency response personnel...

  2. The NASA Astrophysics Program

    NASA Technical Reports Server (NTRS)

    Zebulum, Ricardo S.

    2011-01-01

    NASA's scientists are enjoying unprecedented access to astronomy data from space, both from missions launched and operated only by NASA, as well as missions led by other space agencies to which NASA contributed instruments or technology. This paper describes the NASA astrophysics program for the next decade, including NASA's response to the ASTRO2010 Decadal Survey.

  3. Cardiovascular Performance with E. coli Challenges in a Canine Model of Human Sepsis

    DTIC Science & Technology

    1988-01-01

    most severe peritonitis with volume loading. However, in response to volume, the the largest third space fluid loss (i.e., such animals should...in ESVI represent a greater third space loss from peritoneal in- in infected dogs, i.e., a decrease in contractility. Further- flammation and/or a

  4. Educational Community: Among the Real and Virtual Civic Initiative

    ERIC Educational Resources Information Center

    Arsenijevic, Jasmina; Andevski, Milica

    2016-01-01

    The new media enable numerous advantages in the strengthening of civic engagement, through removing barriers in space and time and through networking of individuals of the same social, civic or political interests at the global level. Different forms of civic engagement and civic responsibility in the virtual space are ever more present, and…

  5. Contingency Operations Support to NASA Johnson Space Center Medical Operations Division

    NASA Technical Reports Server (NTRS)

    Stepaniak, Philip; Patlach, Bob; Swann, Mark; Adams, Adrien

    2005-01-01

    The Wyle Laboratories Contingency Operations Group provides support to the NASA Johnson Space Center (JSC) Medical Operations Division in the event of a space flight vehicle accident or JSC mishap. Support includes development of Emergency Medical System (EMS) requirements, procedures, training briefings and real-time support of mishap investigations. The Contingency Operations Group is compliant with NASA documentation that provides guidance in these areas and maintains contact with the United States Department of Defense (DOD) to remain current on military plans to support NASA. The contingency group also participates in Space Operations Medical Support Training Courses (SOMSTC) and represents the NASA JSC Medical Operations Division at contingency exercises conducted worldwide by the DOD or NASA. The events of September 11, 2001 have changed how this country prepares and protects itself from possible terrorist attacks on high-profile targets. As a result, JSC is now considered a high-profile target and thus, must prepare for and develop a response to a Weapons of Mass Destruction (WMD) incident. The Wyle Laboratories Contingency Operations Group supports this plan, specifically the medical response, by providing expertise and manpower.

  6. 14 CFR § 1259.501 - Responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Responsibilities. § 1259.501 Section § 1259.501 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT... institutional diversity and geographical distribution. ...

  7. 14 CFR 420.51 - Responsibilities-general.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Responsibilities-general. 420.51 Section 420.51 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE TO OPERATE A LAUNCH SITE Responsibilities of a Licensee § 420...

  8. 14 CFR 420.51 - Responsibilities-general.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Responsibilities-general. 420.51 Section 420.51 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE TO OPERATE A LAUNCH SITE Responsibilities of a Licensee § 420...

  9. 14 CFR 431.71 - Public safety responsibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Public safety responsibility. 431.71 Section 431.71 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.71 Public safety responsibility...

  10. 14 CFR 431.71 - Public safety responsibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Public safety responsibility. 431.71 Section 431.71 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.71 Public safety responsibility...

  11. 14 CFR 431.71 - Public safety responsibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Public safety responsibility. 431.71 Section 431.71 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.71 Public safety responsibility...

  12. Influence of Microgravity on Arterial Baroreflex Responses Triggered by Valsalva's Maneuver

    NASA Technical Reports Server (NTRS)

    Eckberg, Dwain L.; Cox, James F.; Tahvanainen, Kari U. O.; Kuusela, Tom A.; Cooke, William H.; Ames, Jimey E.

    2003-01-01

    When astronauts return to Earth and stand upright, their heart rates may speed inordinately, their blood pressures may fall, and some returning astronauts may even faint. Since physiological adjustments to standing are mediated importantly by pressure-regulating reflexes (baroreflexes), we studied involuntary (or autonomic) nerve and blood pressure responses of astronauts to four, 15-second periods of 15- and 30-mmHg straining (Valsalva'. maneuver). We measured the electrocardiogram, finger blood pressure, respiration, and muscle sympathetic nerve activity in four healthy male astronauts before and during the 16-day Neurolab Space Shuttle mission. We found that although microgravity provoked major autonomic changes, no astronaut experienced fainting symptoms after the mission. Blood pressure fell more during straining in space than on Earth (the average reduction of systolic pressure with 30-mmHg straining was 49 mmHg during and 27 mmHg before the mission). However, the increases of muscle sympathetic nerve activity that were triggered by straining were also larger in space than on Earth. As a result, the gain of the sympathetic baroreflex, taken as the total sympathetic nerve response divided by the maximum pressure reduction during straining, was the same in space as on Earth. In contrast, heart rate changes, which are mediated by changes of vagus nerve activity, were smaller in space. This and earlier research suggest that exposure to microgravity augments blood pressure and sympathetic adjustments to Valsalva straining and differentially reduces vagal, but not sympathetic baroreflex responsiveness. The changes that we documented can be explained economically as a consequence of the blood volume reduction that occurs in space.

  13. KENNEDY SPACE CENTER, FLA. - The Honorable Toni Jennings (left), lieutenant governor of the state of Florida, and Frank T. Brogan, president of Florida Atlantic University, receive a briefing on the research that will be conducted in the Space Life Sciences Lab from Dr. Robert J. Ferl (right), director of Space Agriculture Biotechnology Research and Education (SABRE), University of Florida. Jennings and Brogan are speaking at a dedication and ribbon-cutting ceremony for the lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

    NASA Image and Video Library

    2003-11-19

    KENNEDY SPACE CENTER, FLA. - The Honorable Toni Jennings (left), lieutenant governor of the state of Florida, and Frank T. Brogan, president of Florida Atlantic University, receive a briefing on the research that will be conducted in the Space Life Sciences Lab from Dr. Robert J. Ferl (right), director of Space Agriculture Biotechnology Research and Education (SABRE), University of Florida. Jennings and Brogan are speaking at a dedication and ribbon-cutting ceremony for the lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  14. Microbial response to space environment, part B

    NASA Technical Reports Server (NTRS)

    Taylor, G. R.; Chassay, C. E.; Ellis, W. L.; Foster, B. G.; Volz, P. A.; Spizizen, J.; Buecker, H.; Wrenn, R. T.; Simmonds, R. C.; Long, R. A.

    1972-01-01

    The performance of the microbial response to space environment experiment is considered excellent by all investigators. For most microbial systems, only preliminary survival data are available at this time. None of the available data indicate space flight-mediated changes in cell viability or recovery. One quite important observation has been made at this early date, however. The eggs produced after mice had been infected with N. dubius larvae demonstrated a significant decrease in hatchability when compared to identical ground controls. Except for the fact that the Apollo 16 flight larvae had been on board the command module, treatment of the flown larvae and ground control larvae was the same; neither had been exposed to UV irradiation. The significance and implications of this finding are currently being studied.

  15. Eddy current measurement of tube element spacing

    DOEpatents

    Latham, Wayne Meredith; Hancock, Jimmy Wade; Grut, Jayne Marie

    1998-01-01

    A method of electromagnetically measuring the distance between adjacent tube elements in a heat exchanger. A cylindrical, high magnetic permeability ferrite slug is placed in the tube adjacent the spacing to be measured. A bobbin or annular coil type probe operated in the absolute mode is inserted into a second tube adjacent the spacing to be measured. From prior calibrations on the response of the eddy current coil, the signals from the coil, when sensing the presence of the ferrite slug, are used to determine the spacing between the tubes.

  16. 14 CFR § 1214.305 - Payload specialist responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Payload specialist responsibilities. § 1214.305 Section § 1214.305 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Payload Specialists for Space Transportation System (STS) Missions § 1214.305 Payload specialist...

  17. The National Space Program from the Fifties into the Eighties,

    DTIC Science & Technology

    1983-01-01

    force on 3 December 1968. The third space agreement, "Convention on International Uability for Damage Caused by Space Objects," took the longest to...of the civilian space effort; Third , space added to the responsibilities of the Atomic Energy Commission; Fourth, the responsibilities of the National

  18. Classification of pre-sliced pork and Turkey ham qualities based on image colour and textural features and their relationships with consumer responses.

    PubMed

    Iqbal, Abdullah; Valous, Nektarios A; Mendoza, Fernando; Sun, Da-Wen; Allen, Paul

    2010-03-01

    Images of three qualities of pre-sliced pork and Turkey hams were evaluated for colour and textural features to characterize and classify them, and to model the ham appearance grading and preference responses of a group of consumers. A total of 26 colour features and 40 textural features were extracted for analysis. Using Mahalanobis distance and feature inter-correlation analyses, two best colour [mean of S (saturation in HSV colour space), std. deviation of b*, which indicates blue to yellow in L*a*b* colour space] and three textural features [entropy of b*, contrast of H (hue of HSV colour space), entropy of R (red of RGB colour space)] for pork, and three colour (mean of R, mean of H, std. deviation of a*, which indicates green to red in L*a*b* colour space) and two textural features [contrast of B, contrast of L* (luminance or lightness in L*a*b* colour space)] for Turkey hams were selected as features with the highest discriminant power. High classification performances were reached for both types of hams (>99.5% for pork and >90.5% for Turkey) using the best selected features or combinations of them. In spite of the poor/fair agreement among ham consumers as determined by Kappa analysis (Kappa-value<0.4) for sensory grading (surface colour, colour uniformity, bitonality, texture appearance and acceptability), a dichotomous logistic regression model using the best image features was able to explain the variability of consumers' responses for all sensorial attributes with accuracies higher than 74.1% for pork hams and 83.3% for Turkey hams. Copyright 2009 Elsevier Ltd. All rights reserved.

  19. Comparison of polynomial approximations and artificial neural nets for response surfaces in engineering optimization

    NASA Technical Reports Server (NTRS)

    Carpenter, William C.

    1991-01-01

    Engineering optimization problems involve minimizing some function subject to constraints. In areas such as aircraft optimization, the constraint equations may be from numerous disciplines such as transfer of information between these disciplines and the optimization algorithm. They are also suited to problems which may require numerous re-optimizations such as in multi-objective function optimization or to problems where the design space contains numerous local minima, thus requiring repeated optimizations from different initial designs. Their use has been limited, however, by the fact that development of response surfaces randomly selected or preselected points in the design space. Thus, they have been thought to be inefficient compared to algorithms to the optimum solution. A development has taken place in the last several years which may effect the desirability of using response surfaces. It may be possible that artificial neural nets are more efficient in developing response surfaces than polynomial approximations which have been used in the past. This development is the concern of the work.

  20. An analysis of penetration and ricochet phenomena in oblique hypervelocity impact

    NASA Technical Reports Server (NTRS)

    Schonberg, William P.; Taylor, Roy A.; Horn, Jennifer R.

    1988-01-01

    An experimental investigation of phenomena associated with the oblique hypervelocity impact of spherical projectiles on multisheet aluminum structures is described. A model that can be employed in the design of meteoroid and space debris protection systems for space structures is developed. The model consists of equations that relate crater and perforation damage of a multisheet structure to parameters such as projectile size, impact velocity, and trajectory obliquity. The equations are obtained through a regression analysis of oblique hypervelocity impact test data. This data shows that the response of a multisheet structure to oblique impact is significantly different from its response to normal hypervelocity impact. It was found that obliquely incident projectiles produce ricochet debris that can severely damage panels or instrumentation located on the exterior of a space structure. Obliquity effects of high-speed impact must, therefore, be considered in the design of any structure exposed to the meteoroid and space debris environment.

  1. Visioning the Centre for Place and Sustainability Studies through an embodied aesthetic wholeness

    NASA Astrophysics Data System (ADS)

    Sameshima, Pauline; Greenwood, David A.

    2015-03-01

    In the context of research universities, what kind of places and spaces can we create for ourselves that foster a holistic vision of learning and community, a vision that is responsive to the shifting social and ecological landscapes of the Anthropocene? How can these spaces simultaneously address the need to nurture both personal and cultural change? How do the frames we create enhance or limit our place-making? This paper offers one situated response to such questions as it theorizes and describes the arts integrated emergence of the Centre for Place and Sustainability Studies at Lakehead University. Drawing from critical cultural and ecological studies, we problematize creating spaces in both centers and margins, and offer an arts integrated vision of a space for diverse and evolving approaches to sustainability work: a meeting ground characterized by a commitment to parallax and embodied aesthetic wholeness.

  2. 14 CFR 431.71 - Public safety responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Public safety responsibility. 431.71 Section 431.71 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION.... (a) A licensee is responsible for ensuring the safe conduct of an RLV mission and for protecting...

  3. 14 CFR 431.71 - Public safety responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Public safety responsibility. 431.71 Section 431.71 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION.... (a) A licensee is responsible for ensuring the safe conduct of an RLV mission and for protecting...

  4. Association between characteristics of foveal cystoid spaces and short-term responsiveness to ranibizumab for diabetic macular edema.

    PubMed

    Murakami, Tomoaki; Suzuma, Kiyoshi; Uji, Akihito; Yoshitake, Shin; Dodo, Yoko; Fujimoto, Masahiro; Yoshitake, Tatsuya; Miwa, Yuko; Yoshimura, Nagahisa

    2018-05-01

    To investigate the association between the characteristics of foveal cystoid spaces and short-term responsiveness to ranibizumab treatment for diabetic macular edema (DME) at 3 months from the initial injection. We retrospectively reviewed 66 eyes of 61 patients with center-involved DME who received three consecutive ranibizumab injections and following as-needed administrations. We evaluated the relationship between visual improvement at 3 months and the preoperative optical coherence tomography (OCT) parameters including hyperreflective foci, heterogeneous OCT reflectivity, mean levels of OCT reflectivity and height of foveal cystoid spaces. Twenty-three eyes without preoperative hyperreflective foci in the foveal cystoid spaces had significantly greater improvement in the logarithm of the minimum angle of resolution visual acuity (logMAR VA) at 3 months than 43 eyes with foci (P = 0.006). That was similar to the greater reduction in CSF thickness in eyes without lesions after treatment at the same time point (P < 0.001). VA improvement at 3 months was not associated with the height (R = 0.215, P = 0.083) or the reflectivity levels (R = -0.079, P = 0.538) of foveal cystoid spaces. There were no differences in VA changes between eyes with and without heterogeneous reflectivity in foveal cystoid spaces (P = 0.297). Multivariate analyses showed that logMAR VA and the absence of hyperreflective foci in foveal cystoid spaces were associated with VA improvement at 3 months. Hyperreflective foci in foveal cystoid spaces at baseline predict poorer short-term responsiveness to ranibizumab injections for DME.

  5. Next Steps Toward Understanding Human Habitation of Space: Environmental Impacts and Mechanisms

    NASA Technical Reports Server (NTRS)

    Globus, Ruth

    2016-01-01

    Entry into low earth orbit and beyond causes profound shifts in environmental conditions that have the potential to influence human productivity, long term health, and even survival. We now have evidence that microgravity, radiation and/or confinement in space can lead to demonstrably detrimental changes in the cardiovascular (e.g. vessel function, orthostatic intolerance), musculoskeletal (muscle atrophy, bone loss) and nervous (eye, neurovestibular) systems of astronauts. Because of both the limited number of astronauts who have flown (especially females) and the high degree of individual variability in the human population, important unanswered questions about responses to the space environment remain: What are the sex differences with respect to specific physiological systems? Are the responses age-dependent and/or reversible after return to Earth? Do observed detrimental changes that resemble accelerated aging progress continuously over time or plateau? What are the mechanisms of the biological responses? Answering these important questions certainly demands a multi-pronged approach, and the study of multicellular model organisms (such as rodents and flies) already has provided opportunities for exploring those questions in some detail. Recent long duration spaceflight experiments with rodents show that mice in space provide a mammalian model that uniquely combines the influence of reduced gravitational loading with increased physical activity. In addition, multiple investigators have shown that ground-based models that simulate aspects of spaceflight (including rodent hind limb unloading to mimic weightlessness and exposure to ionizing radiation), cause various transient and persistent detrimental consequences in multiple physiological systems. In general, we have found that adverse skeletal effects of simulated weightlessness and space radiation when combined, can be quantitatively, if not qualitatively, different from the influence of each environmental factor alone implying at least some shared underlying mechanisms. Thus, both ground based and spaceflight research utilizing model organisms provide the opportunity to better understand environmental factors and biological mechanisms that contribute to human health and survival in space.

  6. Implications of Responsive Space on the Flight Software Architecture

    NASA Technical Reports Server (NTRS)

    Wilmot, Jonathan

    2006-01-01

    The Responsive Space initiative has several implications for flight software that need to be addressed not only within the run-time element, but the development infrastructure and software life-cycle process elements as well. The runtime element must at a minimum support Plug & Play, while the development and process elements need to incorporate methods to quickly generate the needed documentation, code, tests, and all of the artifacts required of flight quality software. Very rapid response times go even further, and imply little or no new software development, requiring instead, using only predeveloped and certified software modules that can be integrated and tested through automated methods. These elements have typically been addressed individually with significant benefits, but it is when they are combined that they can have the greatest impact to Responsive Space. The Flight Software Branch at NASA's Goddard Space Flight Center has been developing the runtime, infrastructure and process elements needed for rapid integration with the Core Flight software System (CFS) architecture. The CFS architecture consists of three main components; the core Flight Executive (cFE), the component catalog, and the Integrated Development Environment (DE). This paper will discuss the design of the components, how they facilitate rapid integration, and lessons learned as the architecture is utilized for an upcoming spacecraft.

  7. Dusty Pair Plasma—Wave Propagation and Diffusive Transition of Oscillations

    NASA Astrophysics Data System (ADS)

    Atamaniuk, Barbara; Turski, Andrzej J.

    2011-11-01

    The crucial point of the paper is the relation between equilibrium distributions of plasma species and the type of propagation or diffusive transition of plasma response to a disturbance. The paper contains a unified treatment of disturbance propagation (transport) in the linearized Vlasov electron-positron and fullerene pair plasmas containing charged dust impurities, based on the space-time convolution integral equations. Electron-positron-dust/ion (e-p-d/i) plasmas are rather widespread in nature. Space-time responses of multi-component linearized Vlasov plasmas on the basis of multiple integral equations are invoked. An initial-value problem for Vlasov-Poisson/Ampère equations is reduced to the one multiple integral equation and the solution is expressed in terms of forcing function and its space-time convolution with the resolvent kernel. The forcing function is responsible for the initial disturbance and the resolvent is responsible for the equilibrium velocity distributions of plasma species. By use of resolvent equations, time-reversibility, space-reflexivity and the other symmetries are revealed. The symmetries carry on physical properties of Vlasov pair plasmas, e.g., conservation laws. Properly choosing equilibrium distributions for dusty pair plasmas, we can reduce the resolvent equation to: (i) the undamped dispersive wave equations, (ii) and diffusive transport equations of oscillations.

  8. An evaluation of space time cube representation of spatiotemporal patterns.

    PubMed

    Kristensson, Per Ola; Dahlbäck, Nils; Anundi, Daniel; Björnstad, Marius; Gillberg, Hanna; Haraldsson, Jonas; Mårtensson, Ingrid; Nordvall, Mathias; Ståhl, Josefine

    2009-01-01

    Space time cube representation is an information visualization technique where spatiotemporal data points are mapped into a cube. Information visualization researchers have previously argued that space time cube representation is beneficial in revealing complex spatiotemporal patterns in a data set to users. The argument is based on the fact that both time and spatial information are displayed simultaneously to users, an effect difficult to achieve in other representations. However, to our knowledge the actual usefulness of space time cube representation in conveying complex spatiotemporal patterns to users has not been empirically validated. To fill this gap, we report on a between-subjects experiment comparing novice users' error rates and response times when answering a set of questions using either space time cube or a baseline 2D representation. For some simple questions, the error rates were lower when using the baseline representation. For complex questions where the participants needed an overall understanding of the spatiotemporal structure of the data set, the space time cube representation resulted in on average twice as fast response times with no difference in error rates compared to the baseline. These results provide an empirical foundation for the hypothesis that space time cube representation benefits users analyzing complex spatiotemporal patterns.

  9. The physiology of spacecraft and space suit atmosphere selection

    NASA Astrophysics Data System (ADS)

    Waligora, J. M.; Horrigan, D. J.; Nicogossian, A.

    The majority of the environmental factors which comprise the spacecraft and space suit environments can be controlled at "Earth normal" values, at optimum values, or at other values decided upon by spacecraft designers. Factors which are considered in arriving at control values and control ranges of these parameters include physiological, engineering, operational cost, and safety considerations. Several of the physiologic considerations, including hypoxia and hyperoxia, hypercapnia, temperature regulation, and decompression sickness are identified and their impact on space craft and space suit atmosphere selection are considered. The past experience in controlling these parameters in U.S. and Soviet spacecraft and space suits and the associated physiological responses are reviewed. Current areas of physiological investigation relating to environmental factors in spacecraft are discussed, particularly decompression sickness which can occur as a result of change in pressure from Earth to spacecraft or spacecraft to space suit. Physiological considerations for long-term lunar or Martian missions will have different impacts on atmosphere selection and may result in the selection of atmospheres different than those currently in use.

  10. Increasingly complex representations of natural movies across the dorsal stream are shared between subjects.

    PubMed

    Güçlü, Umut; van Gerven, Marcel A J

    2017-01-15

    Recently, deep neural networks (DNNs) have been shown to provide accurate predictions of neural responses across the ventral visual pathway. We here explore whether they also provide accurate predictions of neural responses across the dorsal visual pathway, which is thought to be devoted to motion processing and action recognition. This is achieved by training deep neural networks to recognize actions in videos and subsequently using them to predict neural responses while subjects are watching natural movies. Moreover, we explore whether dorsal stream representations are shared between subjects. In order to address this question, we examine if individual subject predictions can be made in a common representational space estimated via hyperalignment. Results show that a DNN trained for action recognition can be used to accurately predict how dorsal stream responds to natural movies, revealing a correspondence in representations of DNN layers and dorsal stream areas. It is also demonstrated that models operating in a common representational space can generalize to responses of multiple or even unseen individual subjects to novel spatio-temporal stimuli in both encoding and decoding settings, suggesting that a common representational space underlies dorsal stream responses across multiple subjects. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Hearing Scenes: A Neuromagnetic Signature of Auditory Source and Reverberant Space Separation

    PubMed Central

    Oliva, Aude

    2017-01-01

    Abstract Perceiving the geometry of surrounding space is a multisensory process, crucial to contextualizing object perception and guiding navigation behavior. Humans can make judgments about surrounding spaces from reverberation cues, caused by sounds reflecting off multiple interior surfaces. However, it remains unclear how the brain represents reverberant spaces separately from sound sources. Here, we report separable neural signatures of auditory space and source perception during magnetoencephalography (MEG) recording as subjects listened to brief sounds convolved with monaural room impulse responses (RIRs). The decoding signature of sound sources began at 57 ms after stimulus onset and peaked at 130 ms, while space decoding started at 138 ms and peaked at 386 ms. Importantly, these neuromagnetic responses were readily dissociable in form and time: while sound source decoding exhibited an early and transient response, the neural signature of space was sustained and independent of the original source that produced it. The reverberant space response was robust to variations in sound source, and vice versa, indicating a generalized response not tied to specific source-space combinations. These results provide the first neuromagnetic evidence for robust, dissociable auditory source and reverberant space representations in the human brain and reveal the temporal dynamics of how auditory scene analysis extracts percepts from complex naturalistic auditory signals. PMID:28451630

  12. KSC-03PD-3137

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. Frank T. Brogan, president of the Florida Atlantic University, speaks at a dedication and ribbon- cutting ceremony for the Space Life Sciences Lab hosted by NASA- Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  13. KSC-03PD-3139

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. The Honorable Toni Jennings, lieutenant governor of the state of Florida, speaks at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  14. 14 CFR 33.73 - Power or thrust response.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.73 Power or... aircraft, without overtemperature, surge, stall, or other detrimental factors occurring to the engine...

  15. 14 CFR 33.73 - Power or thrust response.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.73 Power or... aircraft, without overtemperature, surge, stall, or other detrimental factors occurring to the engine...

  16. Mechano-biological Coupling of Cellular Responses to Microgravity

    NASA Astrophysics Data System (ADS)

    Long, Mian; Wang, Yuren; Zheng, Huiqiong; Shang, Peng; Duan, Enkui; Lü, Dongyuan

    2015-11-01

    Cellular response to microgravity is a basic issue in space biological sciences as well as space physiology and medicine. It is crucial to elucidate the mechano-biological coupling mechanisms of various biological organisms, since, from the principle of adaptability, all species evolved on the earth must possess the structure and function that adapts their living environment. As a basic element of an organism, a cell usually undergoes mechanical and chemical remodeling to sense, transmit, transduce, and respond to the alteration of gravitational signals. In the past decades, new computational platforms and experimental methods/techniques/devices are developed to mimic the biological effects of microgravity environment from the viewpoint of biomechanical approaches. Mechanobiology of plant gravisensing in the responses of statolith movements along the gravity vector and the relevant signal transduction and molecular regulatory mechanisms are investigated at gene, transcription, and protein levels. Mechanotransduction of bone or immune cell responses and stem cell development and tissue histogenesis are elucidated under microgravity. In this review, several important issues are briefly discussed. Future issues on gravisensing and mechanotransducing mechanisms are also proposed for ground-based studies as well as space missions.

  17. Assessment of the effects of the zero gravity environment on the health and safety of space workers

    NASA Technical Reports Server (NTRS)

    1980-01-01

    A review was conducted of currently available information relating to adverse effects to the health and safety that space power system (SPS) space workers may experience. Currently available information on the responses of humans to space flight is somewhat limited and was obtained under conditions which are grossly different from conditions to be experienced by future space workers. The limitations in information and differences in conditions were considered in the assessment of potential health and safety hazards to the SPS space workers. The study did not disclose any adverse effects that would result in long term deviations to the medical physiological health of space workers so long as proper preventive or ameliorating action were taken.

  18. KSC-03PD-3138

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. Dignitaries, invited guests, space center employees, and the media show their appreciation for the speakers at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  19. Spatial attention in the mental architecture: evidence from neuropsychology.

    PubMed

    Behrmann, M; Black, S E; Murji, S

    1995-04-01

    Using neuropsychological evidence, this paper examines whether spatial attention functions as a domain-specific module or as a more general-purpose central processor. Data are presented from two spatial attention cuing tasks completed by subjects, with an acquired attentional deficit, and control subjects. In both tasks, an arrow indicated with high probability the side of response (response task) or the side of space on which the stimulus would appear (visuospatial task). In the response task, the stimuli appeared foveally and the response component was lateralized, and in the visuospatial task, the stimuli were lateralized and the response component remained constant in the midline. Only the neglect subjects showed a disproportionate increase in reaction time on both the response and visuospatial tasks when the arrow cued the subject to the ipsilateral side and the stimulus or response was on the side of space contralateral to the lesion. The substantial association across the two tasks suggests that a common underlying internal spatial representation subserves perception and action. While this finding is consistent with Fodor's view of a cross-domain processor, it does not meet all of his criteria of a central processor. We conclude, therefore, that the posterior attentional mechanism is strictly neither a module nor a central processor. Rather, these results suggest that a common attentional mechanism may subserve behavior in domains that are tightly coupled.

  20. Spectral gamuts and spectral gamut mapping

    NASA Astrophysics Data System (ADS)

    Rosen, Mitchell R.; Derhak, Maxim W.

    2006-01-01

    All imaging devices have two gamuts: the stimulus gamut and the response gamut. The response gamut of a print engine is typically described in CIE colorimetry units, a system derived to quantify human color response. More fundamental than colorimetric gamuts are spectral gamuts, based on radiance, reflectance or transmittance units. Spectral gamuts depend on the physics of light or on how materials interact with light and do not involve the human's photoreceptor integration or brain processing. Methods for visualizing a spectral gamut raise challenges as do considerations of how to utilize such a data-set for producing superior color reproductions. Recent work has described a transformation of spectra reduced to 6-dimensions called LabPQR. LabPQR was designed as a hybrid space with three explicit colorimetric axes and three additional spectral reconstruction axes. In this paper spectral gamuts are discussed making use of LabPQR. Also, spectral gamut mapping is considered in light of the colorimetric-spectral duality of the LabPQR space.

  1. Effect of space flight on cytokine production

    NASA Astrophysics Data System (ADS)

    Sonnenfeld, Gerald

    Space flight has been shown to alter many immunological responses. Among those affected are the production of cytokines, Cytokines are the messengers of the immune system that facilitate communication among cells that allow the interaction among cells leading to the development of immune responses. Included among the cytokines are the interferons, interleukins, and colony stimulating factors. Cytokines also facilitate communication between the immune system and other body systems, such as the neuroendocrine and musculoskeletal systems. Some cytokines also have direct protective effects on the host, such as interferon, which can inhibit the replication of viruses. Studies in both humans and animals indicate that models of space flight as well as actual space flight alter the production and action of cytokines. Included among these changes are altered interferon production, altered responsiveness of bone marrow cells to granulocyte/monocyte-colony stimulating factor, but no alteration in the production of interleukin-3. This suggests that there are selective effects of space flight on immune responses, i.e. not all cytokines are affected in the same fashion by space flight. Tissue culture studies also suggest that there may be direct effects of space flight on the cells responsible for cytokine production and action. The results of the above study indicate that the effects of space flight on cytokines may be a fundamental mechanism by which space flight not only affects immune responses, but also other biological systems of the human.

  2. Spacecraft Demand Tasking and Skip Entry Responsive Maneuvers

    DTIC Science & Technology

    2011-06-01

    Introduction General Issue Growing in prominence within the policy decisions of the U.S. Department of Defense, the term “responsive space ” represents a...shift from a solution-oriented to a capabilities-oriented approach to space acquisition and space system design, in which the performance of a new...by the development of spacecraft and launch vehicles, an aspect of the responsive space initiative that has garnered increased attention within the

  3. Acquisition of a Biomedical Database of Acute Responses to Space Flight during Commercial Personal Suborbital Flights

    NASA Technical Reports Server (NTRS)

    Charles, John B.; Richard, Elizabeth E.

    2010-01-01

    There is currently too little reproducible data for a scientifically valid understanding of the initial responses of a diverse human population to weightlessness and other space flight factors. Astronauts on orbital space flights to date have been extremely healthy and fit, unlike the general human population. Data collection opportunities during the earliest phases of space flights to date, when the most dynamic responses may occur in response to abrupt transitions in acceleration loads, have been limited by operational restrictions on our ability to encumber the astronauts with even minimal monitoring instrumentation. The era of commercial personal suborbital space flights promises the availability of a large (perhaps hundreds per year), diverse population of potential participants with a vested interest in their own responses to space flight factors, and a number of flight providers interested in documenting and demonstrating the attractiveness and safety of the experience they are offering. Voluntary participation by even a fraction of the flying population in a uniform set of unobtrusive biomedical data collections would provide a database enabling statistical analyses of a variety of acute responses to a standardized space flight environment. This will benefit both the space life sciences discipline and the general state of human knowledge.

  4. Space Food Systems Laboratory

    NASA Technical Reports Server (NTRS)

    Perchonok, Michele; Russo, Dane M. (Technical Monitor)

    2001-01-01

    The Space Food Systems Laboratory (SFSL) is a multipurpose laboratory responsible for space food and package research and development. It is located on-site at Johnson Space Center in Building 17. The facility supports the development of flight food, menus, packaging and food related hardware for Shuttle, International Space Station, and Advanced Life Support food systems. All foods used to support NASA ground tests and/or missions must meet the highest standards before they are 'accepted' for use on actual space flights. The foods are evaluated for nutritional content, sensory acceptability, safety, storage and shelf life, and suitability for use in micro-gravity. The food packaging is also tested to determine its functionality and suitability for use in space. Food Scientist, Registered Dieticians, Packaging Engineers, Food Systems Engineers, and Technicians staff the Space Food Systems Laboratory.

  5. 19 CFR 118.4 - Responsibilities of a CES operator.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...; (j) Provide office space, parking spaces, appropriate sanitary facilities, and potable water to Customs personnel at no charge or a charge of $1 per year; and (k) Perform in accordance with any other..., 1993, as amended by T.D. 94-81, 59 FR 51495, Oct. 12, 1994; T.D. 95-77, 60 FR 50020, Sept. 27, 1995; T...

  6. 19 CFR 118.4 - Responsibilities of a CES operator.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...; (j) Provide office space, parking spaces, appropriate sanitary facilities, and potable water to Customs personnel at no charge or a charge of $1 per year; and (k) Perform in accordance with any other..., 1993, as amended by T.D. 94-81, 59 FR 51495, Oct. 12, 1994; T.D. 95-77, 60 FR 50020, Sept. 27, 1995; T...

  7. 19 CFR 118.4 - Responsibilities of a CES operator.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...; (j) Provide office space, parking spaces, appropriate sanitary facilities, and potable water to Customs personnel at no charge or a charge of $1 per year; and (k) Perform in accordance with any other..., 1993, as amended by T.D. 94-81, 59 FR 51495, Oct. 12, 1994; T.D. 95-77, 60 FR 50020, Sept. 27, 1995; T...

  8. 19 CFR 118.4 - Responsibilities of a CES operator.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...; (j) Provide office space, parking spaces, appropriate sanitary facilities, and potable water to Customs personnel at no charge or a charge of $1 per year; and (k) Perform in accordance with any other..., 1993, as amended by T.D. 94-81, 59 FR 51495, Oct. 12, 1994; T.D. 95-77, 60 FR 50020, Sept. 27, 1995; T...

  9. 19 CFR 118.4 - Responsibilities of a CES operator.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...; (j) Provide office space, parking spaces, appropriate sanitary facilities, and potable water to Customs personnel at no charge or a charge of $1 per year; and (k) Perform in accordance with any other..., 1993, as amended by T.D. 94-81, 59 FR 51495, Oct. 12, 1994; T.D. 95-77, 60 FR 50020, Sept. 27, 1995; T...

  10. Publications of the Exobiology Program for 1985: A special bibliography

    NASA Technical Reports Server (NTRS)

    1987-01-01

    The Exobiology Program, within the Office of Space Science and Applications of the National Aeronautics and Space Administration, is an integrated program to methodically investigate those processes that are responsible for, or related to, the origin, evolution, and distribution of life in the universe. The list of l985 publications resulting from research pursued is contained.

  11. When 1+1=1: the unification of independent actors revealed through joint Simon effects in crossed and uncrossed effector conditions.

    PubMed

    Welsh, Timothy N

    2009-12-01

    The "Simon effect" describes a pattern of reaction times (RTs) where responses to symbolic information are shorter when the information is presented on the same side of space as the desired response than when it is on the opposite side of space. For example, if right hand responses are required for green targets and left hand responses for red targets, RTs with the right hand are shorter when the green target appears on the right side than on the left side. It has been reported that Simon effects also appear when two individuals perform independent components of a Simon effect task. It has been suggested that such joint Simon effects occur because participants represent the action of their partner. It is unclear, however, if the joint Simon effect emerges because: (1) each partner represents the other's action; (2) each partner is using the other person or their response as an environmental reference; or (3) an intra-hemispheric processing advantage due to the lateralized cerebral organization of perceptual and motor systems. The present study distinguished between these possibilities by asking pairs of participants to perform in conditions in which they crossed their arms into the other person's space. Consistent with within-person Simon effects, joint Simon effects were observed in uncrossed- and crossed limb conditions. These results support a response co-representation explanation of joint Simon effects. It is suggested that the processes underlying the evoked representations have developed to allow two independent agents to form temporary synergies to facilitate efficient task completion. 2009 Elsevier B.V. All rights reserved.

  12. Neural source dynamics of brain responses to continuous stimuli: Speech processing from acoustics to comprehension.

    PubMed

    Brodbeck, Christian; Presacco, Alessandro; Simon, Jonathan Z

    2018-05-15

    Human experience often involves continuous sensory information that unfolds over time. This is true in particular for speech comprehension, where continuous acoustic signals are processed over seconds or even minutes. We show that brain responses to such continuous stimuli can be investigated in detail, for magnetoencephalography (MEG) data, by combining linear kernel estimation with minimum norm source localization. Previous research has shown that the requirement to average data over many trials can be overcome by modeling the brain response as a linear convolution of the stimulus and a kernel, or response function, and estimating a kernel that predicts the response from the stimulus. However, such analysis has been typically restricted to sensor space. Here we demonstrate that this analysis can also be performed in neural source space. We first computed distributed minimum norm current source estimates for continuous MEG recordings, and then computed response functions for the current estimate at each source element, using the boosting algorithm with cross-validation. Permutation tests can then assess the significance of individual predictor variables, as well as features of the corresponding spatio-temporal response functions. We demonstrate the viability of this technique by computing spatio-temporal response functions for speech stimuli, using predictor variables reflecting acoustic, lexical and semantic processing. Results indicate that processes related to comprehension of continuous speech can be differentiated anatomically as well as temporally: acoustic information engaged auditory cortex at short latencies, followed by responses over the central sulcus and inferior frontal gyrus, possibly related to somatosensory/motor cortex involvement in speech perception; lexical frequency was associated with a left-lateralized response in auditory cortex and subsequent bilateral frontal activity; and semantic composition was associated with bilateral temporal and frontal brain activity. We conclude that this technique can be used to study the neural processing of continuous stimuli in time and anatomical space with the millisecond temporal resolution of MEG. This suggests new avenues for analyzing neural processing of naturalistic stimuli, without the necessity of averaging over artificially short or truncated stimuli. Copyright © 2018 Elsevier Inc. All rights reserved.

  13. Spaceflight Effects and Molecular Responses in the Mouse Eye: Observations After Shuttle Mission STS-133

    NASA Technical Reports Server (NTRS)

    Prospero-Ponce, Claudia; Zanello, Susana B.; CoreyTheriot, Patricia; Chevez-Barrios, P.

    2012-01-01

    Microgravity-induced cephalad fluid shift and radiation exposure are some of the stressors seen in space exploration. Ocular changes leading to visual impairment in astronauts are of occupational health relevance. Therefore, we analyzed the effects of space flight in the eyes of mice. Six mice were assigned to Flight (FLT), Animal enclosure Module (AEM), or vivarium (VIV) group, respectively. Mice were sacrificed at 1, 5 or 7 days after landing from space. One eye was used for histological and immunohistoche-mistry analysis and the other eye for gene expression profiling. 8-OHdG and caspase-3 immunoreactivity were increased in the retina in FLT samples at return(R+1) compared to AEM/VIV groups, and decreased at day 7 (R+7). beta-amyloid was seen in the nerve fibers at the post-laminar region of the optic nerve in the flight samples (R+7). In addition, oxidative and cellular stress response genes were upregulated in the retina of FLT samples upon landing, and decreased by R+7. According to the results, a reversible molecular damage may occur in the retina of mice exposed to spaceflight followed by protective cellular response.

  14. 14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

  15. 14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

  16. 14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

  17. 14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

  18. 14 CFR Appendix E to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for a Space Flight Participant E Appendix E to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING...

  19. Characterizing the Radiation Survivability of Space Solar Cell Technologies for Heliospheric Missions

    NASA Astrophysics Data System (ADS)

    Lee, J. H.; Walker, D.; Mann, C. J.; Yue, Y.; Nocerino, J. C.; Smith, B. S.; Mulligan, T.

    2016-12-01

    Space solar cells are responsible for powering the majority of heliospheric space missions. This paper will discuss methods for characterizing space solar cell technologies for on-orbit operations that rely on a series of laboratory tests that include measuring the solar cells' beginning of life performance under simulated (e.g. AM0 or air mass zero) sunlight over different operating temperatures and observing their end of life performance following exposure to laboratory-generated charged particle radiation (protons and electrons). The Aerospace Corporation operates a proton implanter as well as electron gun facilities and collaborates with external radiation effects facilities to expose space solar cells or other space technologies to representative space radiation environments (i.e. heliosphere or magnetosphere of Earth or other planets), with goals of characterizing how the technologies perform over an anticipated space mission timeline and, through the application of precision diagnostic capabilities, understanding what part of the solar cell is impacted by varying space radiation environments. More recently, Aerospace has been hosting solar cell flight tests on its previously-flown CubeSat avionics bus, providing opportunities to compare the laboratory tests to on-orbit observations. We hope through discussion of the lessons learned and methods we use to characterize how solar cells perform after space radiation exposure that similar methodology could be adopted by others to improve the state of knowledge on the survivability of other space technologies required for future space missions.

  20. Quantifying ecological thresholds from response surfaces

    Treesearch

    Heather E. Lintz; Bruce McCune; Andrew N. Gray; Katherine A. McCulloh

    2011-01-01

    Ecological thresholds are abrupt changes of ecological state. While an ecological threshold is a widely accepted concept, most empirical methods detect them in time or across geographic space. Although useful, these approaches do not quantify the direct drivers of threshold response. Causal understanding of thresholds detected empirically requires their investigation...

  1. A Hybrid 3D Indoor Space Model

    NASA Astrophysics Data System (ADS)

    Jamali, Ali; Rahman, Alias Abdul; Boguslawski, Pawel

    2016-10-01

    GIS integrates spatial information and spatial analysis. An important example of such integration is for emergency response which requires route planning inside and outside of a building. Route planning requires detailed information related to indoor and outdoor environment. Indoor navigation network models including Geometric Network Model (GNM), Navigable Space Model, sub-division model and regular-grid model lack indoor data sources and abstraction methods. In this paper, a hybrid indoor space model is proposed. In the proposed method, 3D modeling of indoor navigation network is based on surveying control points and it is less dependent on the 3D geometrical building model. This research proposes a method of indoor space modeling for the buildings which do not have proper 2D/3D geometrical models or they lack semantic or topological information. The proposed hybrid model consists of topological, geometrical and semantical space.

  2. Cellular responses and gene expression profile changes due to bleomycin-induced DNA damage in human fibroblasts in space

    PubMed Central

    Kidane, Yared; Feiveson, Alan; Stodieck, Louis; Karouia, Fathi; Ramesh, Govindarajan; Rohde, Larry; Wu, Honglu

    2017-01-01

    Living organisms in space are constantly exposed to radiation, toxic chemicals or reactive oxygen species generated due to increased levels of environmental and psychological stresses. Understanding the impact of spaceflight factors, microgravity in particular, on cellular responses to DNA damage is essential for assessing the radiation risk for astronauts and the mutation rate in microorganisms. In a study conducted on the International Space Station, confluent human fibroblasts in culture were treated with bleomycin for three hours in the true microgravity environment. The degree of DNA damage was quantified by immunofluorescence staining for γ-H2AX, which is manifested in three types of staining patterns. Although similar percentages of these types of patterns were found between flight and ground cells, there was a slight shift in the distribution of foci counts in the flown cells with countable numbers of γ-H2AX foci. Comparison of the cells in confluent and in exponential growth conditions indicated that the proliferation rate between flight and the ground may be responsible for such a shift. We also performed a microarray analysis of gene expressions in response to bleomycin treatment. A qualitative comparison of the responsive pathways between the flown and ground cells showed similar responses with the p53 network being the top upstream regulator. The microarray data was confirmed with a PCR array analysis containing a set of genes involved in DNA damage signaling; with BBC3, CDKN1A, PCNA and PPM1D being significantly upregulated in both flight and ground cells after bleomycin treatment. Our results suggest that whether microgravity affects DNA damage response in space can be dependent on the cell type and cell growth condition. PMID:28248986

  3. Proteometabolomic response of Deinococcus radiodurans exposed to UVC and vacuum conditions: Initial studies prior to the Tanpopo space mission.

    PubMed

    Ott, Emanuel; Kawaguchi, Yuko; Kölbl, Denise; Chaturvedi, Palak; Nakagawa, Kazumichi; Yamagishi, Akihiko; Weckwerth, Wolfram; Milojevic, Tetyana

    2017-01-01

    The multiple extremes resistant bacterium Deinococcus radiodurans is able to withstand harsh conditions of simulated outer space environment. The Tanpopo orbital mission performs a long-term space exposure of D. radiodurans aiming to investigate the possibility of interplanetary transfer of life. The revealing of molecular machinery responsible for survivability of D. radiodurans in the outer space environment can improve our understanding of underlying stress response mechanisms. In this paper, we have evaluated the molecular response of D. radiodurans after the exposure to space-related conditions of UVC irradiation and vacuum. Notably, scanning electron microscopy investigations showed that neither morphology nor cellular integrity of irradiated cells was affected, while integrated proteomic and metabolomic analysis revealed numerous molecular alterations in metabolic and stress response pathways. Several molecular key mechanisms of D. radiodurans, including the tricarboxylic acid cycle, the DNA damage response systems, ROS scavenging systems and transcriptional regulators responded in order to cope with the stressful situation caused by UVC irradiation under vacuum conditions. These results reveal the effectiveness of the integrative proteometabolomic approach as a tool in molecular analysis of microbial stress response caused by space-related factors.

  4. Proteometabolomic response of Deinococcus radiodurans exposed to UVC and vacuum conditions: Initial studies prior to the Tanpopo space mission

    PubMed Central

    Ott, Emanuel; Kawaguchi, Yuko; Kölbl, Denise; Chaturvedi, Palak; Nakagawa, Kazumichi; Yamagishi, Akihiko; Weckwerth, Wolfram

    2017-01-01

    The multiple extremes resistant bacterium Deinococcus radiodurans is able to withstand harsh conditions of simulated outer space environment. The Tanpopo orbital mission performs a long-term space exposure of D. radiodurans aiming to investigate the possibility of interplanetary transfer of life. The revealing of molecular machinery responsible for survivability of D. radiodurans in the outer space environment can improve our understanding of underlying stress response mechanisms. In this paper, we have evaluated the molecular response of D. radiodurans after the exposure to space-related conditions of UVC irradiation and vacuum. Notably, scanning electron microscopy investigations showed that neither morphology nor cellular integrity of irradiated cells was affected, while integrated proteomic and metabolomic analysis revealed numerous molecular alterations in metabolic and stress response pathways. Several molecular key mechanisms of D. radiodurans, including the tricarboxylic acid cycle, the DNA damage response systems, ROS scavenging systems and transcriptional regulators responded in order to cope with the stressful situation caused by UVC irradiation under vacuum conditions. These results reveal the effectiveness of the integrative proteometabolomic approach as a tool in molecular analysis of microbial stress response caused by space-related factors. PMID:29244852

  5. Autogenic Feedback Training Exercise: Controlling Physiological Responses to Mitigate Motion Sickness

    NASA Technical Reports Server (NTRS)

    Walton, Nia; Spencer, Telissa; Cowings, Patricia; Toscano, William B.

    2018-01-01

    During space travel approximately 50 of the crew experience symptoms of motion sickness that can range from mild forms of nausea or dizziness to severe malaise and vomiting1. Developing an effective treatment for these symptoms has become a priority of the National Aeronautics and Space Administration (NASA). Autogenic-Feedback Training Exercise (AFTE) is a nonpharmacological countermeasure for mitigating motion sickness. It involves training subjects to control physiological responses in high stress environments2. The primary goal of this experiment is to evaluate the effectiveness of AFTE for increasing tolerance to motion sickness in high stress environments.

  6. Launch summary for 1980

    NASA Technical Reports Server (NTRS)

    Vostreys, R. W.

    1981-01-01

    Sounding rockets, artificial Earth satellites, and space probes launched betweeen January 1 and December 31, 1980 are listed. Data tabulated for the rocket launchings show launching site, instruments carried, date of launch, agency rocket identification, sponsoring country, experiment discipline, peak altitude, and the experimenter or institution responsible. Tables for satellites and space probes show COSPAR designation, spacecraft name, country, launch date, epoch date, orbit type, apoapsis, periapsis and inclination period. The functions and responsibilities of the World Data Center and the areas of scientific interest at the seven subcenters are defined. An alphabetical listing of experimenters using the sounding rockets is also provided.

  7. Biorhythms and space experiments with nonhuman primates

    NASA Technical Reports Server (NTRS)

    Winget, C. M.

    1977-01-01

    Man's response to exposure to spaceflight and weightlessness is expressed in physiological adjustments which involve his health and ability to function. The amplitude and periodicity of fluctuations in biological processes affect various functions and responses to provocative stimuli. Primates and other species are subjected to tests to determine the consequences of an altered biorhythm on work and performance, emotional stability, biomedical evaluation in space, the ability to cope with the unexpected, and susceptibility to infection, toxicity, radiation, drugs, and stress. Factors in the environment or operational setup which can change the physiological baseline must be determined and controlled.

  8. Ratioing methods for in-flight response calibration of space-based spectro-radiometers, operating in the solar spectral region

    NASA Astrophysics Data System (ADS)

    Lobb, Dan

    2017-11-01

    One of the most significant problems for space-based spectro-radiometer systems, observing Earth from space in the solar spectral band (UV through short-wave IR), is in achievement of the required absolute radiometric accuracy. Classical methods, for example using one or more sun-illuminated diffusers as reflectance standards, do not generally provide methods for monitoring degradation of the in-flight reference after pre-flight characterisation. Ratioing methods have been proposed that provide monitoring of degradation of solar attenuators in flight, thus in principle allowing much higher confidence in absolute response calibration. Two example methods are described. It is shown that systems can be designed for relatively low size and without significant additions to the complexity of flight hardware.

  9. Operationally Responsive Space: Creating Responsive Space for America

    DTIC Science & Technology

    2008-06-20

    programs. Items identified for improvement include: 1 ) Fractured management and accounting , 2 ) Satellite availability, 3) Facilities (Processing...enveloped by our three output tiers. The three tiers: • Tier 1 is an immediate response taking minutes to days. • Tier 2 is a mid term response taking...needs to improve. 2 . Develop a philosophy. 3. Set a direction with specific goals (Fuchs 1 -7). The Department of Space should follow these

  10. Renal and Cardio-Endocrine Responses in Humans to Simulated Microgravity

    NASA Technical Reports Server (NTRS)

    Williams, Gordon H.

    1999-01-01

    The volume regulating systems are integrated to produce an appropriate response to both acute and chronic volume changes. Their responses include changing the levels of the hormones and neural inputs of the involved systems and/or changing the responsiveness of their target tissues. Weightlessness during space travel produces a volume challenge that is unfamiliar to the organism. Thus, it is likely that these volume regulatory mechanisms may respond inappropriately, e.g., a decrease in total body volume in space and abnormal responses to upright posture and stress on return to Earth. A similar "inappropriateness" also can occur in disease states, e.g., congestive heart failure. While it is clear that weightlessness produces profound changes in sodium and volume homeostasis, the mechanisms responsible for these changes are incompletely understood. Confounding this analysis is sleep deprivation, common in space travel, which can also modify volume homeostatic mechanisms. The purpose of this project is to provide the required understanding and then to design appropriate countermeasures to reduce or eliminate the adverse effects of microgravity. To accomplish this we are addressing five Specific Aims: (1) To test the hypothesis that microgravity modifies the acute responsiveness of the renin-angiotensin-aldosterone system (RAAS) and renal blood flow; (2) Does simulated microgravity change the circadian rhythm of the volume- regulating hormones?; (3) Does simulated microgravity change the target tissue responsiveness to angiotensin 11 (AngII)?; (4) Does chronic sleep deprivation modify the circadian rhythm of the RAAS and change the acute responsiveness of this system to posture beyond what a microgravity environment alone does? and (5) What effect does salt restriction have on the volume homeostatic and neurohumoral responses to a microgravity environment? Because the RAAS plays a pivotal role in blood pressure control and volume homeostasis, it likely is a major mediator of the adaptive cardio-renal responses observed during space missions and is a special focus of this project. Thus, the overall goal of this project is to assess the impact of microgravity and sleep deprivation in humans on volume-regulating systems. To achieve this overall objective, we are evaluating renal blood flow and the status and responsiveness of the volume- regulating systems (RAAS, atrial natriuretic peptide and vasopressin), and the adrenergic system (plasma and urine catecholamines) in both simulated microgravity and normal gravity with and -Without sleep deprivation. Furthermore, the responses of the volume homeostatic mechanisms to acute stimulation by upright tilt testing, standing and exercise are being evaluated before and after achieving equilibrium with these interventions.

  11. Categorical clustering of the neural representation of color.

    PubMed

    Brouwer, Gijs Joost; Heeger, David J

    2013-09-25

    Cortical activity was measured with functional magnetic resonance imaging (fMRI) while human subjects viewed 12 stimulus colors and performed either a color-naming or diverted attention task. A forward model was used to extract lower dimensional neural color spaces from the high-dimensional fMRI responses. The neural color spaces in two visual areas, human ventral V4 (V4v) and VO1, exhibited clustering (greater similarity between activity patterns evoked by stimulus colors within a perceptual category, compared to between-category colors) for the color-naming task, but not for the diverted attention task. Response amplitudes and signal-to-noise ratios were higher in most visual cortical areas for color naming compared to diverted attention. But only in V4v and VO1 did the cortical representation of color change to a categorical color space. A model is presented that induces such a categorical representation by changing the response gains of subpopulations of color-selective neurons.

  12. Performance study of galactic cosmic ray shield materials

    NASA Technical Reports Server (NTRS)

    Kim, Myung-Hee Y.; Wilson, John W.; Thibeault, Sheila A.; Nealy, John E.; Badavi, Francis F.; Kiefer, Richard L.

    1994-01-01

    The space program is faced with two difficult radiation protection issues for future long-term operations. First, retrofit of shield material or conservatism in shield design is prohibitively expensive and often impossible. Second, shielding from the cosmic heavy ions is faced with limited knowledge on the physical properties and biological responses of these radiations. The current status of space shielding technology and its impact on radiation health is discussed herein in terms of conventional protection practice and a test biological response model. The impact of biological response on the selection of optimum materials for cosmic ray shielding is presented in terms of the transmission characteristics of the shield material. Although the systematics of nuclear cross sections are able to demonstrate the relation of exposure risk to shield-material composition, the current uncertainty in-nuclear cross sections will not allow an accurate evaluation of risk reduction. This paper presents a theoretical study of risk-related factors and a pilot experiment to study the effectiveness of choice of shield materials to reduce the risk in space operations.

  13. Categorical Clustering of the Neural Representation of Color

    PubMed Central

    Heeger, David J.

    2013-01-01

    Cortical activity was measured with functional magnetic resonance imaging (fMRI) while human subjects viewed 12 stimulus colors and performed either a color-naming or diverted attention task. A forward model was used to extract lower dimensional neural color spaces from the high-dimensional fMRI responses. The neural color spaces in two visual areas, human ventral V4 (V4v) and VO1, exhibited clustering (greater similarity between activity patterns evoked by stimulus colors within a perceptual category, compared to between-category colors) for the color-naming task, but not for the diverted attention task. Response amplitudes and signal-to-noise ratios were higher in most visual cortical areas for color naming compared to diverted attention. But only in V4v and VO1 did the cortical representation of color change to a categorical color space. A model is presented that induces such a categorical representation by changing the response gains of subpopulations of color-selective neurons. PMID:24068814

  14. Valence-space compatibility effects depend on situated motor fluency in both right- and left-handers.

    PubMed

    Milhau, Audrey; Brouillet, Thibaut; Brouillet, Denis

    2015-01-01

    According to the body specificity hypothesis, the way we interact with our environment participates in our conceptualization of concepts and word meanings. For instance, valence is associated to horizontal space because of the motor fluency by which one acts with one's dominant hand. We propose that the decisive factor in the compatibility effects between valence and lateral actions is the interaction between the fluency of response movement and the situational constraints of the task. In a valence judgement task with positive and negative words, right-handers (Experiment 1) and left-handers (Experiment 2) responded with lateralized actions of either their dominant or their nondominant hand. To do so, we used a response device that was either congruent or noncongruent with the fluency of the response hand. Results highlighted that when the response device was congruent with the fluency of the responding hand, response times to positive evaluations were shorter than those to negative evaluations. Conversely, when the response device was noncongruent with the fluency of the responding hand, we observed faster responses for negative evaluations than for positive evaluations. Furthermore, we obtained similar patterns for right- and left-handers, supporting the idea that compatibility effects are driven by the situated fluency of the responding hand.

  15. Slewing control experiment for a flexible panel

    NASA Technical Reports Server (NTRS)

    Juang, Jer-Nan

    1987-01-01

    Technology areas are identified in which better analytical and/or experimental methods are needed to adequately and accurately control the dynamic responses of multibody space platforms such as the space station. A generic space station solar panel is used to experimentally evaluate current control technologies. Active suppression of solar panel vibrations induced by large angle maneuvers is studied with a torque actuator at the root of the solar panel. These active suppression tests will identify the hardware requirements and adequacy of various controller designs.

  16. Novel analysis of 4DCT imaging quantifies progressive increases in anatomic dead space during mechanical ventilation in mice.

    PubMed

    Kim, Elizabeth H; Preissner, Melissa; Carnibella, Richard P; Samarage, Chaminda R; Bennett, Ellen; Diniz, Marcio A; Fouras, Andreas; Zosky, Graeme R; Jones, Heather D

    2017-09-01

    Increased dead space is an important prognostic marker in early acute respiratory distress syndrome (ARDS) that correlates with mortality. The cause of increased dead space in ARDS has largely been attributed to increased alveolar dead space due to ventilation/perfusion mismatching and shunt. We sought to determine whether anatomic dead space also increases in response to mechanical ventilation. Mice received intratracheal lipopolysaccharide (LPS) or saline and mechanical ventilation (MV). Four-dimensional computed tomography (4DCT) scans were performed at onset of MV and after 5 h of MV. Detailed measurements of airway volumes and lung tidal volumes were performed using image analysis software. The forced oscillation technique was used to obtain measures of airway resistance, tissue damping, and tissue elastance. The ratio of airway volumes to total tidal volume increased significantly in response to 5 h of mechanical ventilation, regardless of LPS exposure, and airways demonstrated significant variation in volumes over the respiratory cycle. These findings were associated with an increase in tissue elastance (decreased lung compliance) but without changes in tidal volumes. Airway volumes increased over time with exposure to mechanical ventilation without a concomitant increase in tidal volumes. These findings suggest that anatomic dead space fraction increases progressively with exposure to positive pressure ventilation and may represent a pathological process. NEW & NOTEWORTHY We demonstrate that anatomic dead space ventilation increases significantly over time in mice in response to mechanical ventilation. The novel functional lung-imaging techniques applied here yield sensitive measures of airway volumes that may have wide applications. Copyright © 2017 the American Physiological Society.

  17. Functional subdivisions in low-frequency primary auditory cortex (AI).

    PubMed

    Wallace, M N; Palmer, A R

    2009-04-01

    We wished to test the hypothesis that there are modules in low-frequency AI that can be identified by their responsiveness to communication calls or particular regions of space. Units were recorded in anaesthetised guinea pig AI and stimulated with conspecific vocalizations and a virtual motion stimulus (binaural beats) presented via a closed sound system. Recording tracks were mainly oriented orthogonally to the cortical surface. Some of these contained units that were all time-locked to the structure of the chutter call (14/22 tracks) and/or the purr call (12/22 tracks) and/or that had a preference for stimuli from a particular region of space (8/20 tracks with four contralateral, two ipsilateral and two midline), or where there was a strong asymmetry in the response to beats of different direction (two tracks). We conclude that about half of low-frequency AI is organized into modules that are consistent with separate "what" and "where" pathways.

  18. 14 CFR 431.45 - Mishap investigation plan and emergency response plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Mishap investigation plan and emergency response plan. 431.45 Section 431.45 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...) Notification within 24 hours to the Associate Administrator for Commercial Space Transportation in the event of...

  19. [Assessment of the Space Station Program

    NASA Technical Reports Server (NTRS)

    Kerrebrock, Jack L.

    1994-01-01

    This letter report by the National Research Council's (NRC's) Aeronautics and Space Engineering Board addresses comments on NASA's response to the Board's 1993 letter report, NASA's response to technical and management recommendations from previous NRC technical reports on the Space Station, and an assessment of the current International Space Station Alpha (ISSA) program.

  20. DeafSpace and the principles of universal design.

    PubMed

    Edwards, Claire; Harold, Gill

    2014-01-01

    Recent debates about the epistemological origins of Universal Design (UD) have questioned how far universalist design approaches can address the particularities and diversities of the human form through a series of standardised, technical responses. This article contributes to these debates by discussing an emergent architectural paradigm known as DeafSpace, which articulates a set of design principles originating from the d/Deaf community in the US. Commentary. DeafSpace has emerged as a design paradigm rooted in an expression of d/Deaf cultural identity based around sign language, rather than as a response designed to compensate for, or minimise, impairment. It distinguishes itself from UD by articulating a more user-centred design process, but its principles are arguably rooted in notions of d/Deaf identity based around consensus and homogeneity, with less attention paid to the socio-political contexts which shape diverse experiences of d/Deafness and the exclusion(s) of d/Deaf people from the built environment. While proponents of DeafSpace argue that UD and DeafSpace are not mutually exclusive, nor DeafSpace principles applicable only to d/Deaf people, questions remain about the type of spaces DeafSpace creates, most notably whether they lead to the creation of particularist spaces of and for the d/Deaf community, or reflect a set of design principles which can be embedded across a range of different environments. Implications for Rehabilitation UD as a basis for rehabilitation has been critiqued on the basis that creates "standardised", or universal solutions, thus negating the particularities of the human form. DeafSpace is an architectural paradigm rooted in socio-linguistic understandings of Deafness and the cultural identity of the Deaf community. It challenges UD's technocratic emphasis on minimising impairment and asserts design which is rooted in a more qualitative understanding of individuals' relationship with their environment. DeafSpace seeks to place the user more centrally in the design process and draw on the experiential knowledge of (Deaf) users. However, it has less to say about the often exclusionary socio-political relations which underlie the built environment and shape the diverse experience of deafness. DeafSpace raises questions about how the needs of particular groups can be met through UD principles and in turn whether DeafSpace principles lead to the creation of separate spaces for the D/deaf community.

  1. Registered Nurses' and nurse assistants' responses to older persons' expressions of emotional needs in home care.

    PubMed

    Höglander, Jessica; Eklund, Jakob Håkansson; Eide, Hilde; Holmström, Inger K; Sundler, Annelie J

    2017-12-01

    This study aims to explore nurse assistants' and Registered Nurses' responses to older persons' expressions of emotional needs during home care visits. Communication is a central aspect of care. Older persons might express different emotions and needs during home care visits and such expressions can be challenging to respond to. Little is known about communication in home care or nursing staff responses to older persons' expressed emotional needs. Descriptive, cross-sectional design on nursing staff responses to older persons' negative emotions in home care. Collected data consisted of audio recordings of home care visits between older persons and nursing staff. Data were collected between August 2014-November 2015. The nursing staff responses to older persons' negative emotions in the communication were analysed with the Verona Coding Definitions of Emotional Sequences (VR-CoDES). The nursing staff most often give non-explicit responses, providing space for further disclosure of older persons' expressed negative emotions. Such responses were more frequent if the nursing staff had elicited the older persons' expressions of a negative emotion than if such expressions were elicited by the older persons themselves. Most frequent types of responses were backchannel, active invitation or information advice. The nursing staff responses were mainly non-explicit responses providing space for older persons to tell more about their experiences. Such responses can be discussed in terms of person-centred communication and is important for the comfort of emotional concerns. © 2017 John Wiley & Sons Ltd.

  2. Smart active pilot-in-the-loop systems

    NASA Astrophysics Data System (ADS)

    Thomas, Segun

    1995-04-01

    Representation of on-orbit microgravity environment in a 1-g environment is a continuing problem in space engineering analysis, procedures development and crew training. A way of adequately depicting weightlessness in the performance of on-orbit tasks is by a realistic (or real-time) computer based representation that provides the look, touch, and feel of on-orbit operation. This paper describes how a facility, the Systems Engineering Simulator at the Johnson Space Center, is utilizing recent advances in computer processing power and multi- processing capability to intelligently represent all systems, sub-systems and environmental elements associated with space flight operations. It first describes the computer hardware and interconnection between processors; the computer software responsible for task scheduling, health monitoring, sub-system and environment representation; control room and crew station. It then describes, the mathematical models that represent the dynamics of contact between the Mir and the Space Shuttle during the upcoming US and Russian Shuttle/Mir space mission. Results are presented comparing the response of the smart, active pilot-in-the-loop system to non-time critical CRAY model. A final example of how these systems are utilized is given in the development that supported the highly successful Hubble Space Telescope repair mission.

  3. The dream of a nation

    NASA Technical Reports Server (NTRS)

    Martinez, Alfredo

    1988-01-01

    A challenging new era is under consideration and on its way. With it, comes new problems and questions to solve and answer. Nevertheless, positive thinking is required of all those who participate in or share part of the Space Station's responsibility. Hence, no longer is space an unknown, unreachable environment. It is simply a place for men and women to live, work, and learn.

  4. Process modelling for Space Station experiments

    NASA Technical Reports Server (NTRS)

    Alexander, J. Iwan D.; Rosenberger, Franz; Nadarajah, Arunan; Ouazzani, Jalil; Amiroudine, Sakir

    1990-01-01

    Examined here is the sensitivity of a variety of space experiments to residual accelerations. In all the cases discussed the sensitivity is related to the dynamic response of a fluid. In some cases the sensitivity can be defined by the magnitude of the response of the velocity field. This response may involve motion of the fluid associated with internal density gradients, or the motion of a free liquid surface. For fluids with internal density gradients, the type of acceleration to which the experiment is sensitive will depend on whether buoyancy driven convection must be small in comparison to other types of fluid motion, or fluid motion must be suppressed or eliminated. In the latter case, the experiments are sensitive to steady and low frequency accelerations. For experiments such as the directional solidification of melts with two or more components, determination of the velocity response alone is insufficient to assess the sensitivity. The effect of the velocity on the composition and temperature field must be considered, particularly in the vicinity of the melt-crystal interface. As far as the response to transient disturbances is concerned, the sensitivity is determined by both the magnitude and frequency of the acceleration and the characteristic momentum and solute diffusion times. The microgravity environment, a numerical analysis of low gravity tolerance of the Bridgman-Stockbarger technique, and modeling crystal growth by physical vapor transport in closed ampoules are discussed.

  5. The hindlimb unloading rat model: literature overview, technique update and comparison with space flight data

    NASA Technical Reports Server (NTRS)

    Morey-Holton, Emily; Globus, Ruth K.; Kaplansky, Alexander; Durnova, Galina

    2005-01-01

    The hindlimb unloading rodent model is used extensively to study the response of many physiological systems to certain aspects of space flight, as well as to disuse and recovery from disuse for Earth benefits. This chapter describes the evolution of hindlimb unloading, and is divided into three sections. The first section examines the characteristics of 1064 articles using or reviewing the hindlimb unloading model, published between 1976 and April 1, 2004. The characteristics include number of publications, journals, countries, major physiological systems, method modifications, species, gender, genetic strains and ages of rodents, experiment duration, and countermeasures. The second section provides a comparison of results between space flown and hindlimb unloading animals from the 14-day Cosmos 2044 mission. The final section describes modifications to hindlimb unloading required by different experimental paradigms and a method to protect the tail harness for long duration studies. Hindlimb unloading in rodents has enabled improved understanding of the responses of the musculoskeletal, cardiovascular, immune, renal, neural, metabolic, and reproductive systems to unloading and/or to reloading on Earth with implications for both long-duration human space flight and disuse on Earth.

  6. Immune response during space flight.

    PubMed

    Criswell-Hudak, B S

    1991-01-01

    The health status of an astronaut prior to and following space flight has been a prime concern of NASA throughout the Apollo series of lunar landings, Skylab, Apollo-Soyuz Test Projects (ASTP), and the new Spacelab-Shuttle missions. Both humoral and cellular immunity has been studied using classical clinical procedures. Serum proteins show fluctuations that can be explained with adaptation to flight. Conversely, cellular immune responses of lymphocytes appear to be depressed in both in vivo as well as in vitro. If this depression in vivo and in vitro is a result of the same cause, then man's adaptation to outer space living will present interesting challenges in the future. Since the cause may be due to reduced gravity, perhaps the designs of the experiments for space flight will offer insights at the cellular levels that will facilitate development of mechanisms for adaptation. Further, if the aging process is viewed as an adaptational concept or model and not as a disease process then perhaps space flight could very easily interact to supply some information on our biological time clocks.

  7. Group Analysis in FieldTrip of Time-Frequency Responses: A Pipeline for Reproducibility at Every Step of Processing, Going From Individual Sensor Space Representations to an Across-Group Source Space Representation.

    PubMed

    Andersen, Lau M

    2018-01-01

    An important aim of an analysis pipeline for magnetoencephalographic (MEG) data is that it allows for the researcher spending maximal effort on making the statistical comparisons that will answer his or her questions. The example question being answered here is whether the so-called beta rebound differs between novel and repeated stimulations. Two analyses are presented: going from individual sensor space representations to, respectively, an across-group sensor space representation and an across-group source space representation. The data analyzed are neural responses to tactile stimulations of the right index finger in a group of 20 healthy participants acquired from an Elekta Neuromag System. The processing steps covered for the first analysis are MaxFiltering the raw data, defining, preprocessing and epoching the data, cleaning the data, finding and removing independent components related to eye blinks, eye movements and heart beats, calculating participants' individual evoked responses by averaging over epoched data and subsequently removing the average response from single epochs, calculating a time-frequency representation and baselining it with non-stimulation trials and finally calculating a grand average, an across-group sensor space representation. The second analysis starts from the grand average sensor space representation and after identification of the beta rebound the neural origin is imaged using beamformer source reconstruction. This analysis covers reading in co-registered magnetic resonance images, segmenting the data, creating a volume conductor, creating a forward model, cutting out MEG data of interest in the time and frequency domains, getting Fourier transforms and estimating source activity with a beamformer model where power is expressed relative to MEG data measured during periods of non-stimulation. Finally, morphing the source estimates onto a common template and performing group-level statistics on the data are covered. Functions for saving relevant figures in an automated and structured manner are also included. The protocol presented here can be applied to any research protocol where the emphasis is on source reconstruction of induced responses where the underlying sources are not coherent.

  8. Innovative Methods for the Benefit of Public Health Using Space Technologies for Disaster Response.

    PubMed

    Dinas, Petros C; Mueller, Christian; Clark, Nathan; Elgin, Tim; Nasseri, S Ali; Yaffe, Etai; Madry, Scott; Clark, Jonathan B; Asrar, Farhan

    2015-06-01

    Space applications have evolved to play a significant role in disaster relief by providing services including remote sensing imagery for mitigation and disaster damage assessments; satellite communication to provide access to medical services; positioning, navigation, and timing services; and data sharing. Common issues identified in past disaster response and relief efforts include lack of communication, delayed ordering of actions (eg, evacuations), and low levels of preparedness by authorities during and after disasters. We briefly summarize the Space for Health (S4H) Team Project, which was prepared during the Space Studies Program 2014 within the International Space University. The S4H Project aimed to improve the way space assets and experiences are used in support of public health during disaster relief efforts. We recommend an integrated solution based on nano-satellites or a balloon communication system, mobile self-contained relief units, portable medical scanning devices, and micro-unmanned vehicles that could revolutionize disaster relief and disrupt different markets. The recommended new system of coordination and communication using space assets to support public health during disaster relief efforts is feasible. Nevertheless, further actions should be taken by governments and organizations in collaboration with the private sector to design, test, and implement this system.

  9. Study Design to Test the Hypothesis That Long-Term Space Travel Harms the Human and Animal Immune Systems

    NASA Technical Reports Server (NTRS)

    Shearer, William T.; Lugg, Desmond J.; Ochs, H. D.; Pierson, Duane L.; Reuben, James M.; Rosenblatt, Howard M.; Sams, Clarence; Smith, C. Wayne; Smith, E. Obrian; Smolen, James E.

    1999-01-01

    The potential threat of immunosuppression and abnormal inflammatory responses in long-term space travel, leading to unusual predilection for opportunistic infections, malignancy, and death, is of ma or concern to the National Aeronautics and Space Administration (NASA) Program. This application has been devised to seek answers to questions of altered immunity in space travel raised by previous investigations spanning 30-plus years. We propose to do this with the help of knowledge gained by the discovery of the molecular basis of many primary and secondary immunodeficiency diseases and by application of molecular and genetic technology not previously available. Two areas of immunity that previously received little attention in space travel research will be emphasized: specific antibody responses and non-specific inflammation and adhesion. Both of these areas of research will not only add to the growing body of information on the potential effects of space travel on the immune system, but be able to delineate any functional alterations in systems important for antigen presentation, specific immune memory, and cell:cell and cell:endothelium interactions. By more precisely defining molecular dysfunction of components of the immune system, it is hoped that targeted methods of prevention of immune damage in space could be devised.

  10. High-Resolution and Analytical TEM Investigation of Space Radiation Processing Effects in Primitive Solar System Materials and Airless Planetary Surface Environments

    NASA Technical Reports Server (NTRS)

    Christoffersen, R.; Rahman, Z.; Keller, L. P.; Dukes, C.; Baragiola, R.

    2012-01-01

    Energetic ions present in the diverse plasma conditions in space play a significant role in the formation and modification of solid phases found in environments ranging from the interstellar medium (ISM) to the surfaces of airless bodies such as asteroids and the Moon. These effects are often referred to as space radiation processing, a term that encompasses changes induced in natural space-exposed materials that may be only structural, such as in radiation-induced amorphization, or may involve ion-induced nanoscale to microscale chemical changes, as occurs in preferential sputtering and ion-beam mixing. Ion sputtering in general may also be responsible for partial or complete erosion of space exposed materials, in some instances possibly bringing about the complete destruction of free-floating solid grains in the ISM or in circumstellar nebular dust clouds. We report here on two examples of the application of high-resolution and analytical transmission electron microscopy (TEM) to problems in space radiation processing. The first problem concerns the role of space radiation processing in controlling the overall fate of Fe sulfides as hosts for sulfur in the ISM. The second problem concerns the known, but as yet poorly quantified, role of space radiation processing in lunar space weathering.

  11. Cardiovascular regulatory response to lower body negative pressure following blood volume loss

    NASA Technical Reports Server (NTRS)

    Shimizu, M.; Ghista, D. N.; Sandler, H.

    1979-01-01

    An attempt is made to explain the cardiovascular regulatory responses to lower body negative pressure (LBNP) stress, both in the absence of and following blood or plasma volume loss, the latter being factors regularly observed with short- or long-term recumbency or weightlessness and associated with resulting cardiovascular deconditioning. Analytical expressions are derived for the responses of mean venous pressure and blood volume pooled in the lower body due to LBNP. An analysis is presented for determining the HR change due to LBNP stress following blood volume loss. It is concluded that the reduced orthostatic tolerance following long-term space flight or recumbency can be mainly attributed to blood volume loss, and that the associated cardiovascular responses characterizing this orthostatic intolerance is elicited by the associated central venous pressure response.

  12. CSLAA and FAA'S Rules: Incorporating a 'Risk Management Framework' to Minimise Human Space Flight Risks

    NASA Astrophysics Data System (ADS)

    Chaddha, S.

    2012-01-01

    th This year marks the 50 anniversary of a landmark victory for humankind in its endeavour of entering and exploring the final frontier. During these years of space activity, we have witnessed a number of cumulative successes. One of which is the emergence of the commercial human space flight, or "space tourism", market. Commercial companies have the aim of travelling people into space safely and affordably. This paper shall consider the U.S. regulatory framework governing the space tourism market. It scrutinises the adequacy of the Commercial Space Launch and Amendment Act of 2004 (CSLAA), as bolstered by the FAA's requirements, to protect launching passengers to an acceptable standard of safety from the inherent risks associated with human space flights. It is argued that the legislative regime embeds a three-limb "risk management framework" as an appropriate response to address the concern over the safety of public space travel.

  13. Wetlab-2 - Quantitative PCR Tools for Spaceflight Studies of Gene Expression Aboard the International Space Station

    NASA Technical Reports Server (NTRS)

    Schonfeld, Julie E.

    2015-01-01

    Wetlab-2 is a research platform for conducting real-time quantitative gene expression analysis aboard the International Space Station. The system enables spaceflight genomic studies involving a wide variety of biospecimen types in the unique microgravity environment of space. Currently, gene expression analyses of space flown biospecimens must be conducted post flight after living cultures or frozen or chemically fixed samples are returned to Earth from the space station. Post-flight analysis is limited for several reasons. First, changes in gene expression can be transient, changing over a timescale of minutes. The delay between sampling on Earth can range from days to months, and RNA may degrade during this period of time, even in fixed or frozen samples. Second, living organisms that return to Earth may quickly re-adapt to terrestrial conditions. Third, forces exerted on samples during reentry and return to Earth may affect results. Lastly, follow up experiments designed in response to post-flight results must wait for a new flight opportunity to be tested.

  14. Reward magnitude, but not time of day, influences the trial-spacing effect in autoshaping with rats.

    PubMed

    Thomas, B; Huneycutt, D; Papini, M R

    1998-12-01

    The arousal hypothesis of the trial-spacing effect suggests that spaced-trial training increases emotional arousal and thus invigorates Pavlovian behavior, relative to massed-trial conditions. Emotional arousal was manipulated by varying reinforcer magnitude during training (either one or five food pellets/trial, across groups). In addition, autoshaping training was administered either in the morning (0900 h) or in the evening (1700 h). Rats were housed in an enclosed colony room and exposed to a regular light:dark cycle (light from 0700 to 1900 h). Available evidence indicates that reinforcer magnitude and time of day are related to arousal levels. As expected, a larger reinforcer magnitude led to a highly significant trial spacing effect. Evening training led to a higher response rate than morning training, but the trial-spacing effect was equally strong whether training was administered in the morning or in the evening. These results provide partial support for the arousal hypothesis and are discussed in the context of research on schedule-induced behavior.

  15. 49 CFR 1.23 - Spheres of primary responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and technology, commercial space transportation, intelligence and security, and public affairs. (b... technology cooperation; international visitors' programs; economic regulation of the airline industry; and... any negotiated rulemaking relating to, or having an impact on, projects, programs, or funding...

  16. 49 CFR 1.23 - Spheres of primary responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and technology, commercial space transportation, intelligence and security, and public affairs. (b... technology cooperation; international visitors' programs; economic regulation of the airline industry; and... any negotiated rulemaking relating to, or having an impact on, projects, programs, or funding...

  17. Space Architecture: The Role, Work and Aptitude

    NASA Technical Reports Server (NTRS)

    Griffin, Brand

    2014-01-01

    Space architecture has been an emerging discipline for at least 40 years. Has it arrived? Is space architecture a legitimate vocation or an avocation? If it leads to a job, what do employers want? In 2002, NASA Headquarters created a management position for a space architect whose job was to "lead the development of strategic architectures and identify high level requirements for systems that will accomplish the Nation's space exploration vision." This is a good job description with responsibility at the right level in NASA, but unfortunately, the office was discontinued two years later. Even though there is no accredited academic program or professional licensing for space architecture, there is a community of practitioners. They are civil servants, contractors and academicians supporting International Space Station and space exploration programs. In various ways, space architects currently contribute to human spaceflight, but there is a way for the discipline to be more effective in developing solutions to large scale complex problems. This paper organizes contributions from engineers, architects and psychologists into recommendations on the role of space architects in the organization, the process of creating and selecting options, and intrinsic personality traits including why they must have a high tolerance for ambiguity.

  18. Immunological and Hematopoietic Biotechnology Studies

    NASA Technical Reports Server (NTRS)

    Fernandez-Botran, Rafael; Sonnenfeld, Gerald

    1996-01-01

    The purpose of the work carried under this interchanges was to support the development of space flight biotechnology experiments in the areas of immunology and hematopoiesis to facilitate the commercial development of space. The studies involved the interaction and development of experiments with biotechnology companies for necessary ground-based studies to allow the development of flight studies. The thrust of the work was to develop experiments with the Chiron Corporation and Bioserve involving the use of interleukin-2 to modulate the effects of spaceflight on immune responses. Spaceflight has been shown to have multiple effects on immune responses (1). lnterleukin-2 is an immuno-regulator that could have potential to counter some of the alterations induced in immune responses by spaceflight (1). To test this possibility before flight, rats were suspended antiorthostatically (2) and treated with interleukin-2. Antiorthostatic suspension is a model for some of the effects of spaceflight on immune responses (2). The interleukin-2 was given to see if it could alter some of the effects of suspension. This was achieved. As a result of these studies, two flight experiments were developed and flown with the Chiron Corp. And Bioserve to determine if use of interleukin-2 could prevent or attenuate the effects of space flight on immune responses.

  19. 24 CFR 970.11 - Procedures for the offer of sale to established eligible organizations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... amount and use of non-dwelling space, the current physical condition (fire damaged, friable asbestos... express its interest, in writing, in response to the PHA's offer to sell the property proposed for... proposal. (e) Response to the notice of sale. The established eligible organization or organizations have...

  20. Practice nurses mental health provide space to patients to discuss unpleasant emotions.

    PubMed

    Griep, E C M; Noordman, J; van Dulmen, S

    2016-03-01

    WHAT IS KNOWN ON THE SUBJECT?: A core skill of practice nurses' mental health is to recognize and explore patients' unpleasant emotions. Patients rarely express their unpleasant emotions directly and spontaneously, but instead give indirect signs that something is worrying them. WHAT THIS PAPER ADDS TO EXISTING KNOWLEDGE?: Patients with mild psychosocial and psychological problems provide signs of worrying or express a clear unpleasant emotion in 94% of consultations with a practice nurse mental health. Nurses' responses to patients' signs of worrying or clear unpleasant emotions were mostly characterized by providing space for patients to talk about these emotions, by using minimal responses. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Practice nurses' mental health have passive listening skills, and to a lesser extent, use active listening techniques. Accurate emotion detection and the ability to pick out emotional signs during consultations must also be considered as an important skill for health providers to improve patient-centred communication. Patients with physical problems are known to express their emotional concerns in an implicit way only. Whether the same counts for patients presenting mental health problems in primary care is unknown. This study aims to examine how patients with mild psychosocial and psychological complaints express their concerns during consultations with the practice nurse mental health and how practice nurses respond to these expressions. Fifteen practice nurses mental health working in Dutch general practices participated in the study. Their consultations with 116 patients with mild psychosocial or psychological complaints were video recorded. patients' explicitly expressed emotional concerns and more implicit expressions of underlying emotional problems (cues) as well as nurses' responses to these expressions were rated using the Verona Coding Definition of Emotional Sequences. Almost all consultations contained at least one cue or concern (94%). Nurses' responses were mostly characterized by providing space for patients to talk about their cue or concern in a non-explicit way (62%), by using minimal responses (42%). Practice nurses mental health have passive listening skills, and to a lesser extent, use active listening techniques. However, there are no strict rules which way of responding is the best and patients value responses differently. © 2015 John Wiley & Sons Ltd.

  1. Face-infringement space: the frame of reference of the ventral intraparietal area.

    PubMed

    McCollum, Gin; Klam, François; Graf, Werner

    2012-07-01

    Experimental studies have shown that responses of ventral intraparietal area (VIP) neurons specialize in head movements and the environment near the head. VIP neurons respond to visual, auditory, and tactile stimuli, smooth pursuit eye movements, and passive and active movements of the head. This study demonstrates mathematical structure on a higher organizational level created within VIP by the integration of a complete set of variables covering face-infringement. Rather than positing dynamics in an a priori defined coordinate system such as those of physical space, we assemble neuronal receptive fields to find out what space of variables VIP neurons together cover. Section 1 presents a view of neurons as multidimensional mathematical objects. Each VIP neuron occupies or is responsive to a region in a sensorimotor phase space, thus unifying variables relevant to the disparate sensory modalities and movements. Convergence on one neuron joins variables functionally, as space and time are joined in relativistic physics to form a unified spacetime. The space of position and motion together forms a neuronal phase space, bridging neurophysiology and the physics of face-infringement. After a brief review of the experimental literature, the neuronal phase space natural to VIP is sequentially characterized, based on experimental data. Responses of neurons indicate variables that may serve as axes of neural reference frames, and neuronal responses have been so used in this study. The space of sensory and movement variables covered by VIP receptive fields joins visual and auditory space to body-bound sensory modalities: somatosensation and the inertial senses. This joining of allocentric and egocentric modalities is in keeping with the known relationship of the parietal lobe to the sense of self in space and to hemineglect, in both humans and monkeys. Following this inductive step, variables are formalized in terms of the mathematics of graph theory to deduce which combinations are complete as a multidimensional neural structure that provides the organism with a complete set of options regarding objects impacting the face, such as acceptance, pursuit, and avoidance. We consider four basic variable types: position and motion of the face and of an external object. Formalizing the four types of variables allows us to generalize to any sensory system and to determine the necessary and sufficient conditions for a neural center (for example, a cortical region) to provide a face-infringement space. We demonstrate that VIP includes at least one such face-infringement space.

  2. A dynamic model of the radiation-belt electron phase-space density based on POLAR/HIST measurements

    NASA Astrophysics Data System (ADS)

    Vassiliadis, D.; Green, J. C.

    2007-12-01

    The response of the energetic-electron phase-space density (PSD) in the radiation belts is subject to a delicate combination of acceleration and loss processes which are strongly determined by the magnetospheric configuration and field disturbance level. We quantify the response of the density to stormtime fields as observed by the HIST detector on board POLAR. Several distinct modes are identified, characterized by peak second- and third- adiabatic invariants and peak delay time. The modes represent quasiadiabatic transport due to ring current activity; high L* (~6), day-long acceleration linked to ULF wave-particle interaction; and low-L* (~3), minute- to hour-long acceleration interpreted to be due to transient inductive fields or VLF wave-particle interaction. The net transport due to these responses is not always or everywhere diffusive, therefore we quantify the degree of departure from diffusive transport for specific storm intervals and radial ranges. Taken together the response modes comprise a dynamic, nonlinear model which allows us to better understand the historic variability of the high-energy tail of the electron distribution in the inner magnetosphere.

  3. Men and Women in Space: Bone Loss and Kidney Stone Risk after Long-Duration Space Flight

    NASA Technical Reports Server (NTRS)

    Smith, Scott M.; Zwart, Sara R.; Heer, Martina; Hudson, Edgar, K.; Shackelford, Linda; Morgan, Jennifer L. L.

    2014-01-01

    Bone loss on Earth is more prevalent in women than men, leading to the assumption that women may be at greater risk from bone loss during flight. Until recently, the number of women having flown long-duration missions was too small to allow any type of statistical analysis. We report here data from 42 astronauts on long-duration missions to the International Space Station, 33 men and 9 women. Bone mineral density (dual-energy X-ray absorptiometry), bone biochemistry (from blood and urine samples), and renal stone risk factors were evaluated before and after flight. Data were analyzed in two groups, based on available resistance exercise equipment. The response of bone mineral density to flight was the same for men and women, and the typical decrease in bone mineral density (whole body and/or regional) after flight was not observed for either sex for those using an Advanced Resistive Exercise Device. Bone biochemistry, specifically markers of formation and resorption, generally responded similarly in male and female astronauts. The response of urinary supersaturation risk to space flight was not significantly different between men and women, although risks were typically increased after flight in both groups and risks were generally greater in men than in women before and after flight. Overall, the bone and renal stone responses of men and women to space flight were not different.

  4. Bumper 3 Update for IADC Protection Manual

    NASA Technical Reports Server (NTRS)

    Christiansen, Eric L.; Nagy, Kornel; Hyde, Jim

    2016-01-01

    The Bumper code has been the standard in use by NASA and contractors to perform meteoroid/debris risk assessments since 1990. It has undergone extensive revisions and updates [NASA JSC HITF website; Christiansen et al., 1992, 1997]. NASA Johnson Space Center (JSC) has applied BUMPER to risk assessments for Space Station, Shuttle, Mir, Extravehicular Mobility Units (EMU) space suits, and other spacecraft (e.g., LDEF, Iridium, TDRS, and Hubble Space Telescope). Bumper continues to be updated with changes in the ballistic limit equations describing failure threshold of various spacecraft components, as well as changes in the meteoroid and debris environment models. Significant efforts are expended to validate Bumper and benchmark it to other meteoroid/debris risk assessment codes. Bumper 3 is a refactored version of Bumper II. The structure of the code was extensively modified to improve maintenance, performance and flexibility. The architecture was changed to separate the frequently updated ballistic limit equations from the relatively stable common core functions of the program. These updates allow NASA to produce specific editions of the Bumper 3 that are tailored for specific customer requirements. The core consists of common code necessary to process the Micrometeoroid and Orbital Debris (MMOD) environment models, assess shadowing and calculate MMOD risk. The library of target response subroutines includes a board range of different types of MMOD shield ballistic limit equations as well as equations describing damage to various spacecraft subsystems or hardware (thermal protection materials, windows, radiators, solar arrays, cables, etc.). The core and library of ballistic response subroutines are maintained under configuration control. A change in the core will affect all editions of the code, whereas a change in one or more of the response subroutines will affect all editions of the code that contain the particular response subroutines which are modified. Note that the Bumper II program is no longer maintained or distributed by NASA.

  5. A statistical approach to understanding reproductive isolation in two sympatric species of tree crickets.

    PubMed

    Bhattacharya, Monisha; Isvaran, Kavita; Balakrishnan, Rohini

    2017-04-01

    In acoustically communicating animals, reproductive isolation between sympatric species is usually maintained through species-specific calls. This requires that the receiver be tuned to the conspecific signal. Mapping the response space of the receiver onto the signal space of the conspecific investigates this tuning. A combinatorial approach to investigating the response space is more informative as the influence on the receiver of the interactions between the features is also elucidated. However, most studies have examined individual preference functions rather than the multivariate response space. We studied the maintenance of reproductive isolation between two sympatric tree cricket species ( Oecanthus henryi and Oecanthus indicus ) through the temporal features of the calls. Individual response functions were determined experimentally for O. henryi , the results from which were combined in a statistical framework to generate a multivariate quantitative receiver response space. The predicted response was higher for the signals of the conspecific than for signals of the sympatric heterospecific, indicating maintenance of reproductive isolation through songs. The model allows prediction of response to untested combinations of temporal features as well as delineation of the evolutionary constraints on the signal space. The model can also be used to predict the response of O. henryi to other heterospecific signals, making it a useful tool for the study of the evolution and maintenance of reproductive isolation via long-range acoustic signals. © 2017. Published by The Company of Biologists Ltd.

  6. Data Collection for Disaster Response from the International Space Station

    NASA Astrophysics Data System (ADS)

    Stefanov, W. L.; Evans, C. A.

    2015-04-01

    Remotely sensed data acquired by orbital sensor systems has emerged as a vital tool to identify the extent of damage resulting from a natural disaster, as well as providing near-real time mapping support to response efforts on the ground and humanitarian aid efforts. The International Space Station (ISS) is a unique terrestrial remote sensing platform for acquiring disaster response imagery. Unlike automated remote-sensing platforms it has a human crew; is equipped with both internal and externally-mounted remote sensing instruments; and has an inclined, low-Earth orbit that provides variable views and lighting (day and night) over 90 percent of the inhabited surface of the Earth. As such, it provides a useful complement to autonomous sensor systems in higher altitude polar orbits. NASA remote sensing assets on the station began collecting International Charter, Space and Major Disasters, also known informally as the International Disaster Charter (IDC) response data in May 2012. Since the start of IDC response in 2012, and as of late March 2015, there have been 123 IDC activations; NASA sensor systems have collected data for thirty-four of these events. Of the successful data collections, eight involved two or more ISS sensor systems responding to the same event. Data has also been collected by International Partners in response to natural disasters, most notably JAXA and Roscosmos/Energia through the Urugan program.

  7. Microgravity Effects on Microbiology In Space Laboratories

    NASA Technical Reports Server (NTRS)

    Nelson, Emily S.; Juergensmeyer, Elizabeth; Juergensmeyer, Margaret

    2000-01-01

    Here we present a review of the effects of residual acceleration on microorganisms in space Laboratories. Residual acceleration in the microgravity environment is frequently ignored by microbiologists, although their experiments may be as sensitive to this acceleration as those designed by materials scientists and fluid physicists. Furthermore, analysis to date has been largely empirical and/or based on very simple theoretical models. As a result, the responses of single cells to the space environment are widely assumed to be taking place in "pure" microgravity. These responses vary widely and are not well understood. Some of this variation may be due to the range of microgravity conditions experience by organisms. In the future, as we move from visiting orbital environments to living and working there, we will undoubtedly bring microorganisms with us. It is also quite likely that the first extraterrestrial life we encounter will be single-celled organisms. Therefore, we would like to present a summary of the current knowledge base, and to challenge the space community to develop new approaches in understanding this important field.

  8. Comparative evaluation of Space Transportation System (STS)-3 flight and acoustic test random vibration response of the OSS-1 payload

    NASA Technical Reports Server (NTRS)

    On, F. J.

    1983-01-01

    A comparative evaluation of the Space Transportation System (STS)-3 flight and acoustic test random vibration response of the Office of Space Science-1 (OSS-1) payload is presented. The results provide insight into the characteristics of vibroacoustic response of pallet payload components in the payload bay during STS flights.

  9. Method for Constructing Composite Response Surfaces by Combining Neural Networks with other Interpolation or Estimation Techniques

    NASA Technical Reports Server (NTRS)

    Rai, Man Mohan (Inventor); Madavan, Nateri K. (Inventor)

    2003-01-01

    A method and system for design optimization that incorporates the advantages of both traditional response surface methodology (RSM) and neural networks is disclosed. The present invention employs a unique strategy called parameter-based partitioning of the given design space. In the design procedure, a sequence of composite response surfaces based on both neural networks and polynomial fits is used to traverse the design space to identify an optimal solution. The composite response surface has both the power of neural networks and the economy of low-order polynomials (in terms of the number of simulations needed and the network training requirements). The present invention handles design problems with many more parameters than would be possible using neural networks alone and permits a designer to rapidly perform a variety of trade-off studies before arriving at the final design.

  10. A novel phototropic response to red light is revealed in microgravity.

    PubMed

    Millar, Katherine D L; Kumar, Prem; Correll, Melanie J; Mullen, Jack L; Hangarter, Roger P; Edelmann, Richard E; Kiss, John Z

    2010-05-01

    The aim of this study was to investigate phototropism in plants grown in microgravity conditions without the complications of a 1-g environment. Experiments performed on the International Space Station (ISS) were used to explore the mechanisms of both blue-light- and red-light-induced phototropism in plants. This project utilized the European Modular Cultivation System (EMCS), which has environmental controls for plant growth as well as centrifuges for gravity treatments used as a 1-g control. Images captured from video tapes were used to analyze the growth, development, and curvature of Arabidopsis thaliana plants that developed from seed in space. A novel positive phototropic response to red light was observed in hypocotyls of seedlings that developed in microgravity. This response was not apparent in seedlings grown on Earth or in the 1-g control during the space flight. In addition, blue-light-based phototropism had a greater response in microgravity compared with the 1-g control. Although flowering plants are generally thought to lack red light phototropism, our data suggest that at least some flowering plants may have retained a red light sensory system for phototropism. Thus, this discovery may have important implications for understanding the evolution of light sensory systems in plants.

  11. Coupled Facility-Payload Vibration Modeling Improvements

    NASA Technical Reports Server (NTRS)

    Carnahan, Timothy M.; Kaiser, Michael A.

    2015-01-01

    A major phase of aerospace hardware verification is vibration testing. The standard approach for such testing is to use a shaker to induce loads into the payload. In preparation for vibration testing at National Aeronautics and Space Administration/Goddard Space Flight Center an analysis is performed to assess the responses of the payload. A new method of modeling the test is presented that takes into account dynamic interactions between the facility and the payload. This dynamic interaction has affected testing in the past, but been ignored or adjusted for during testing. By modeling the combined dynamics of the facility and test article (payload) it is possible to improve the prediction of hardware responses. Many aerospace test facilities work in similar way to those at NASA/Goddard Space Flight Center. Lessons learned here should be applicable to other test facilities with similar setups.

  12. International Space Station Environmental Control and Life Support Emergency Response Verification for Node 1

    NASA Technical Reports Server (NTRS)

    Williams, David E.

    2008-01-01

    The International Space Station (ISS) Node 1 Environmental Control and Life Support (ECLS) System is comprised of five subsystems: Atmosphere Control and Supply (ACS), Atmosphere Revitalization (AR), Fire Detection and Suppression (FDS), Temperature and Humidity Control (THC), and Water Recovery and Management (WRM). This paper provides a summary of the Node 1 Emergency Response capability, which includes nominal and off-nominal FDS operation, off nominal ACS operation, and off-nominal THC operation. These subsystems provide the capability to help aid the crew members during an emergency cabin depressurization, a toxic spill, or a fire. The paper will also provide a discussion of the detailed Node 1 ECLS Element Verification methodologies for operation of the Node 1 Emergency Response hardware operations utilized during the Qualification phase.

  13. KENNEDY SPACE CENTER, FLA. - Officials of the NASA-Kennedy Space Center and the state of Florida pose for a group portrait at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab at the new lab. From left are Capt. Winston Scott, executive director of the Florida Space Authority; Dr. Robert J. Ferl, director of Space Agriculture Biotechnology Research and Education (SABRE), University of Florida; Charlie Quincy, chief of the Biological Sciences Office, Kennedy Space Center; Jose Perez-Morales, NASA Project Manager for the Space Life Sciences Lab; Jim Kennedy, director of the Kennedy Space Center; The Honorable Toni Jennings, lieutenant governor of the state of Florida; Frank T. Brogan, president of the Florida Atlantic University; and Dr. Samuel Durrance, executive director of the Florida Space Research Institute. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

    NASA Image and Video Library

    2003-11-19

    KENNEDY SPACE CENTER, FLA. - Officials of the NASA-Kennedy Space Center and the state of Florida pose for a group portrait at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab at the new lab. From left are Capt. Winston Scott, executive director of the Florida Space Authority; Dr. Robert J. Ferl, director of Space Agriculture Biotechnology Research and Education (SABRE), University of Florida; Charlie Quincy, chief of the Biological Sciences Office, Kennedy Space Center; Jose Perez-Morales, NASA Project Manager for the Space Life Sciences Lab; Jim Kennedy, director of the Kennedy Space Center; The Honorable Toni Jennings, lieutenant governor of the state of Florida; Frank T. Brogan, president of the Florida Atlantic University; and Dr. Samuel Durrance, executive director of the Florida Space Research Institute. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  14. Overall Genomic Effects of the exposure to real and simulated gravity during Drosophila melanogaster metamorphosis

    NASA Astrophysics Data System (ADS)

    Marco, Roberto; Herranz, Raul; Lavan, David; Villa, Aida; Medina, Francisco Javier; van Loon, Jack W. A.

    The availability of genomic information and of high through-put analysis techniques makes possible to investigate and understand the genetic basis of ecologically important traits, traits that could increase the fitness of the different organisms towards the different characteristics of the environment in which they are normally living and therefore are adapted. As recently discussed (1), it is not an easy task to identify among the global transcription response, the probably smaller group of genes with discernible relevance to the particular perturbation analyzed. The issue whether the challenge experienced by the biological systems is "familiar" or "evolutionary novel" is relevant to our experiments. Combining/modifying the type of environmental challenges and looking for the correlation among the genes responses is one way to substantiate the relevance of the results. Nevertheless, the more relevant genes involved in a particular response may not show the more important changes in expression levels as has been shown for hubs with high connectivity in interaction networks. To integrate the findings from gene expression changes with the experiments performed with more direct experimental approaches is a challenge for the immediate future. When we started our analysis, we were expecting to detect a relatively small group of gravity responding genes. On the other hand, we think now that the overall genome is responding to the evolutionary novel environment. The experiments on which we base our analysis are: a) experiments in the International Space Station, b) experiments performed on ground microgravity simulating equipment, mainly on the Random Position Machine and experiments under hypergravity, namely at 10g, well above the acceleration felt by the organisms during the launch of the space shifts that are used in the orbital experiments. The actual developmental process studied is the Drosophila metamorphosis. The pupae at the end of the developmental period where the adult flies are formed, starting from the larvae, provides an appropriated system where to answer the question, how general is the transcriptional response of a high organism such as Drosophila when exposed at unusual conditions such as those prevalent in Space and reproduced on the ground with more or less fidelity. Space experiments are always associated to strict experimental constraints caused by the specific requirements linked to this highly unusual environment. These constraints were partially introduced to make possible the fixation of our pupae in Space. The required levels of containment had the consequence of providing a limited amount of oxygen to the pupae inside the hermetic Type I container. Furthermore, it was necessary to cool down the early pupae to make possible that the majority of the pupal development occurred in Space. The compatibility of these constraints with the pupal development was tested. Furthermore, the ground control simulations could be run with or without the constraints. The results that will be reviewed in the presentation: metricconverterProductID1. A1. A large proportion of the genes responded to the Space conditions, very likely mostly to microgravity. 2. The constraints actually reinforced the gene response produced by the exposure to microgravity, making easier to detect the positive effect. 3. The Space results could be almost exactly reproduced on the ground simulation conditions. 5. Hypergravity although triggering a much less conspicuous response than microgravity, interestingly, changed the gene expression in an opposite directions to the one triggered by microgravity. The significance of these effects in long-term multigenerational experiments could provide the genetic basis for the adaptation to the new environmental parameters and indicate the way evolution could proceed. Manned space missions and the development of life support systems should take these findings into account. 1) Koonin, E. V. Chance and necessity in cellular response to challenge. Molecular Systems Biology (2007), 3

  15. The immune system in space and microgravity

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, Gerald

    2002-01-01

    Space flight and models that created conditions similar to those that occur during space flight have been shown to affect a variety of immunological responses. These have primarily been cell-mediated immune responses including leukocyte proliferation, cytokine production, and leukocyte subset distribution. The mechanisms and biomedical consequences of these changes remain to be established. Among the possible causes of space flight-induced alterations in immune responses are exposure to microgravity, exposure to stress, exposure to radiation, and many more as yet undetermined causes. This review chronicles the known effects of space flight on the immune system and explores the possible role of stress in contributing to these changes.

  16. Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation

    NASA Technical Reports Server (NTRS)

    Brand, S. N.

    1985-01-01

    The results of a series of simulation studies of calcium matabolic changes which have been recorded during human exposure to bed rest and space flight are presented. Space flight and bed rest data demonstrate losses of total body calcium during exposure to hypogravic environments. These losses are evidenced by higher than normal rates of urine calcium excretion and by negative calcium balances. In addition, intestinal absorption rates and bone mineral content are assumed to decrease. The bed rest and space flight simulations were executed on a mathematical model of the calcium metabolic system. The purpose of the simulations is to theoretically test hypotheses and predict system responses which are occurring during given experimental stresses. In this case, hypogravity occurs through the comparison of simulation and experimental data and through the analysis of model structure and system responses. The model reliably simulates the responses of selected bed rest and space flight parameters. When experimental data are available, the simulated skeletal responses and regulatory factors involved in the responses agree with space flight data collected on rodents. In addition, areas within the model that need improvement are identified.

  17. Systemic Microgravity Response: Utilizing GeneLab to Develop Hypotheses for Spaceflight Risks

    NASA Technical Reports Server (NTRS)

    Beheshti, Afshin; Fogle, Homer; Galazka, Jonathan; Kidane, Yared; Chakravarty, Kaushik; Berrios, Daniel C.; Costes, Sylvain V.

    2017-01-01

    Biological risks associated with microgravity is a major concern for space travel. Although determination of risk has been a focus for NASA research, data examining systemic (i.e., multi- or pan-tissue) responses to space flight are sparse. The overall goal of our work is to identify potential master regulators responsible for such responses to microgravity conditions. To do this we utilized the NASA GeneLab database which contains a wide array of omics experiments, including data from: 1) different flight conditions (space shuttle (STS) missions vs. International Space Station (ISS); 2) different tissues; and 3) different types of assays that measure epigenetic, transcriptional, and protein expression changes. We have performed meta-analysis identifying potential master regulators involved with systemic responses to microgravity. The analysis used 7 different murine and rat data sets, examining the following tissues: liver, kidney, adrenal gland, thymus, mammary gland, skin, and skeletal muscle (soleus, extensor digitorum longus, tibialis anterior, quadriceps, and gastrocnemius). Using a systems biology approach, we were able to determine that p53 and immune related pathways appear central to pan-tissue microgravity responses. Evidence for a universal response in the form of consistency of change across tissues in regulatory pathways was observed in both STS and ISS experiments with varying durations; while degree of change in expression of these master regulators varied across species and strain, some change in these master regulators was universally observed. Interestingly, certain skeletal muscle (gastrocnemius and soleus) show an overall down-regulation in these genes, while in other types (extensor digitorum longus, tibialis anterior and quadriceps) they are up-regulated, suggesting certain muscle tissues may be compensating for atrophy responses caused by microgravity. Studying these organtissue-specific perturbations in molecular signaling networks, we demonstrate the value of GeneLab in characterizing potential master regulators associated with biological risks for spaceflight.

  18. Study of the Microphonics for Prospective Space-Based Neutron and Gamma-Ray Detectors and Methods for its Suppression

    NASA Astrophysics Data System (ADS)

    Vostrukhin, A. A.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Malakhov, A. V.; Mitrofanov, I. G.; Mokrousov, M. I.; Tomilina, T. M.; Bobrovnitskiy, Yu. I.; Grebennikov, A. S.; Laktionova, M. M.; Bakhtin, B. N.; Sotov, A. V.

    2018-05-01

    The results of testing a number of space-based detectors that contain PMTs or high-voltage electrodes for the noise from the microphonics that occurs in the signal path due to external mechanical action have been presented. A method for the vibration isolation of instruments aboard a spacecraft has been proposed to reduce their responsivity to vibrations.

  19. A Model for Predicting Thermomechanical Response of Large Space Structures.

    DTIC Science & Technology

    1985-06-01

    Field in a Thermomechanically Heated Viscoplastic ....... Space Truss Structure 6.5 Analysis of a Thermoviscoplastic Uniaxial " Bar Under Prescribed...Stress Part I - Theoretical Development . -- 6.6 Analysis of a Thermoviscoplastic Uniaxial codes Bar Under Prescribed Stress Part II - or Boundary Layer...and Asymptotic Analysis 6.7 Analysis of a Thermoviscoplastic Uniaxial Bar Under Prescribed Stress Part III - Numerical Results for a Bar with Radiative

  20. 14 CFR 431.81 - Financial responsibility requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Financial responsibility requirements. 431.81 Section 431.81 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION...-Licensing Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.81 Financial...

  1. 14 CFR 431.81 - Financial responsibility requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Financial responsibility requirements. 431.81 Section 431.81 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION...-Licensing Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.81 Financial...

  2. 14 CFR 431.81 - Financial responsibility requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Financial responsibility requirements. 431.81 Section 431.81 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION...-Licensing Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.81 Financial...

  3. 14 CFR 431.81 - Financial responsibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Financial responsibility requirements. 431.81 Section 431.81 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION...-Licensing Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.81 Financial...

  4. 14 CFR 431.81 - Financial responsibility requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Financial responsibility requirements. 431.81 Section 431.81 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION...-Licensing Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.81 Financial...

  5. Using Autonomous Bio Nanosatellites for Deep Space Exploration

    NASA Astrophysics Data System (ADS)

    Santa Maria, S. R.; Liddell, L. C.; Tieze, S. M.; Ricco, A. J.; Hanel, R.; Bhattacharya, S.

    2018-02-01

    NASA's BioSentinel mission will conduct the first study of biological response to deep-space radiation in 45 years. It is an automated nanosatellite that will measure the DNA damage response to ambient space radiation in a model biological organism.

  6. Some design philosophy for reducing the community noise of advanced counter-rotation propellers

    NASA Technical Reports Server (NTRS)

    Dittmar, J. H.

    1985-01-01

    Advanced counter-rotation propellers have been indicated as possibly generating an unacceptable amount of noise for the people living near an airport. This report has explored ways to reduce this noise level, which is treated as being caused by the interaction of the upstream propeller wakes and vortices with the downstream propeller. The noise reduction techniques fall into two categories: (1) reducing the strength of the wakes and vortices, and (2) reducing the response of the downstream blades to them. The noise from the wake interaction was indicated as being reduced by increased propeller spacing and decreased blade drag coefficient. The vortex-interaction noise could be eliminated by having the vortex pass over the tips of the downstream blade, and it could be reduced by increased spacing or decreased initial circulation. The downstream blade response could be lessened by increasing the reduced frequency parameter omega or by phasing of the response from different sections to have a mutual cancellation effect. Uneven blade to blade spacing for the downstream blading was indicated as having a possible effect on the annoyance of counter-rotation propeller noise. Although there are undoubtedly additional methods of noise reduction not covered in this report, the inclusion of the design methods discussed would potentially result in a counter-rotation propeller that is acceptably quiet.

  7. Space Flight-Associated Neuro-ocular Syndrome.

    PubMed

    Lee, Andrew G; Mader, Thomas H; Gibson, C Robert; Tarver, William

    2017-09-01

    New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight-associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station. These clinical findings have included unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts. The clinical findings of SANS have been correlated with structural changes on intraorbital and intracranial magnetic resonance imaging and in-flight and terrestrial ultrasonographic studies and ocular optical coherence tomography. Further study of SANS is ongoing for consideration of future manned missions to space, including a return trip to the moon or Mars.

  8. Survey of cell biology experiments in reduced gravity

    NASA Technical Reports Server (NTRS)

    Taylor, G. R.

    1977-01-01

    The effects of spaceflight on terrestrial cell systems are discussed. With some important exceptions, static cell systems carried aboard U.S.A. and U.S.S.R. space flights have failed to reveal space related anomalies. Some sophisticated devices which were developed for viewing directly, or continuously recording, the growth of cells, tissue cultures and eggs in flight, are described and the results summarized. The unique presence of high energy, multicharged (HZE) particles and full-range ultraviolet irradiation in space prompted evaluation of the response of single cells to these factors. Summary results and general conclusions are presented. Potential areas of research in future space flights are identified.

  9. The influence of vertical motor responses on explicit and incidental processing of power words.

    PubMed

    Jiang, Tianjiao; Sun, Lining; Zhu, Lei

    2015-07-01

    There is increasing evidence demonstrating that power judgment is affected by vertical information. Such interaction between vertical space and power (i.e., response facilitation under space-power congruent conditions) is generally elicited in paradigms that require participants to explicitly evaluate the power of the presented words. The current research explored the possibility that explicit evaluative processing is not a prerequisite for the emergence of this effect. Here we compared the influence of vertical information on a standard explicit power evaluation task with influence on a task that linked power with stimuli in a more incidental manner, requiring participants to report whether the words represented people or animals or the font of the words. The results revealed that although the effect is more modest, the interaction between responses and power is also evident in an incidental task. Furthermore, we also found that explicit semantic processing is a prerequisite to ensure such an effect. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Keep your hands crossed: the valence-by-left/right interaction is related to hand, not side, in an incongruent hand-response key assignment.

    PubMed

    de la Vega, Irmgard; Dudschig, Carolin; De Filippis, Mónica; Lachmair, Martin; Kaup, Barbara

    2013-02-01

    The body-specificity hypothesis (Casasanto, 2009) associates positive emotional valence and the space surrounding the dominant hand, and negative valence and the space surrounding the non-dominant hand. This effect has not only been found for manual responses, but also for the left and right side. In the present study, we investigated whether this compatibility effect still shows when hand and side carry incongruent information, and whether it is then related to hand or to side. We conducted two experiments which used an incongruent hand-response key assignment, that is, participants had their hands crossed. Participants were instructed to respond with their right vs. left hand (Experiment 1) or with the right vs. left key (Experiment 2). In both experiments, a compatibility effect related to hand emerged, indicating that the association between hand and valence overrides the one between side and valence when hand and side carry contradicting information. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Lessons Learned From the Development, Operation, and Review of Mechanical Systems on the Space Shuttle, International Space Station, and Payloads

    NASA Technical Reports Server (NTRS)

    Dinsel, Alison; Jermstad, Wayne; Robertson, Brandan

    2006-01-01

    The Mechanical Design and Analysis Branch at the Johnson Space Center (JSC) is responsible for the technical oversight of over 30 mechanical systems flying on the Space Shuttle Orbiter and the International Space Station (ISS). The branch also has the responsibility for reviewing all mechanical systems on all Space Shuttle and International Space Station payloads, as part of the payload safety review process, through the Mechanical Systems Working Group (MSWG). These responsibilities give the branch unique insight into a large number of mechanical systems, and problems encountered during their design, testing, and operation. This paper contains narrative descriptions of lessons learned from some of the major problems worked on by the branch during the last two years. The problems are grouped into common categories and lessons learned are stated.

  12. Integrating Multiple Space Ground Sensors to Track Volcanic Activity

    NASA Technical Reports Server (NTRS)

    Chien, Steve; Davies, Ashley; Doubleday, Joshua; Tran, Daniel; Jones, Samuel; Kjartansson, Einar; Thorsteinsson, Hrobjartur; Vogfjord, Kristin; Guomundsson, Magnus; Thordarson, Thor; hide

    2011-01-01

    Volcanic activity can occur with little or no warning. Increasing numbers of space borne assets can enable coordinated measurements of volcanic events to enhance both scientific study and hazard response. We describe the use of space and ground measurements to target further measurements as part of a worldwide volcano monitoring system. We utilize a number of alert systems including the MODVOLC, GOESVOLC, US Air Force Weather Advisory, and Volcanic Ash Advisory Center (VAAC) alert systems. Additionally we use in-situ data from ground instrumentation at a number of volcanic sites, including Iceland.

  13. NF-kB activation and its downstream target genes expression after heavy ions exposure

    NASA Astrophysics Data System (ADS)

    Chishti, Arif Ali; Baumstark-Khan, Christa; Hellweg, Christine; Schmitz, Claudia; Koch, Kristina; Feles, Sebastian

    2016-07-01

    To enable long-term human space flight cellular radiation response to densely ionizing radiation needs to be better understood for developing appropriate countermeasures to mitigate acute effects and late radiation risks for the astronaut. The biological effectiveness of accelerated heavy ions (which constitute the most important radiation type in space) with high linear energy transfer (LET) for effecting DNA damage response pathways as a gateway to cell death or survival is of major concern not only for space missions but also for new regimes of tumor radiotherapy. In the current research study, the contribution of NF-κB in response to space-relevant radiation qualities was determined by a NF-κB reporter cell line (HEK-pNF-κB-d2EGFP/Neo L2). The NF-κB dependent reporter gene expression (d2EGFP) after ionizing radiation (X-rays and heavy ions) exposure was evaluated by flow cytometry. Because of differences in the extent of NF-κB activation after X-irradiation and heavy ions exposure, it was expected that radiation quality (LET) might play an important role in the cellular radiation response. In addition, the biological effectiveness (RBE) of NF-κB activation and reduction of cellular survival was examined for heavy ions having a broad range of LET (˜0.3 - 9674 keV/µm). Furthermore, the effect of LET on NF-κB target gene expression was analyzed by real time reverse transcriptase quantitative PCR (RT-qPCR). In this study it was proven that NF-κB activation and NF-κB dependent gene expression comprises an early step in cellular radiation response. Taken together, this study clearly demonstrates that NF-κB activation and NF-κB-dependent gene expression by heavy ions are highest in the LET range of ˜50-200 keV/μupm. The up-regulated chemokines and cytokines (CXCL1, CXCL2, CXCL10, IL-8 and TNF) might be important for cell-cell communication among hit as well as unhit cells (bystander effect). The results obtained suggest the NF-κB pathway to be a promising target for pharmacological modulation of cellular radiation response either to improve tumor cell killing during radiotherapy with heavy ions or to mitigate radiation late effects in astronauts or irradiated healthy tissue.

  14. Space Shuttle operational logistics plan

    NASA Technical Reports Server (NTRS)

    Botts, J. W.

    1983-01-01

    The Kennedy Space Center plan for logistics to support Space Shuttle Operations and to establish the related policies, requirements, and responsibilities are described. The Directorate of Shuttle Management and Operations logistics responsibilities required by the Kennedy Organizational Manual, and the self-sufficiency contracting concept are implemented. The Space Shuttle Program Level 1 and Level 2 logistics policies and requirements applicable to KSC that are presented in HQ NASA and Johnson Space Center directives are also implemented.

  15. Infection prevention and control during prolonged human space travel.

    PubMed

    Mermel, Leonard A

    2013-01-01

    Prolonged human spaceflight to another planet or an asteroid will introduce unique challenges of mitigating the risk of infection. During space travel, exposure to microgravity, radiation, and stress alter human immunoregulatory responses, which can in turn impact an astronaut's ability to prevent acquisition of infectious agents or reactivation of latent infection. In addition, microgravity affects virulence, growth kinetics, and biofilm formation of potential microbial pathogens. These interactions occur in a confined space in microgravity, providing ample opportunity for heavy microbial contamination of the environment. In addition, there is the persistence of aerosolized, microbe-containing particles. Any mission involving prolonged human spaceflight must be carefully planned to minimize vulnerabilities and maximize the likelihood of success.

  16. 14 CFR 1214.207 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... the STS Program § 1214.207 Responsibilities. (a) Headquarters officials. (1) The NASA Comptroller, in... the NASA Issuance System, and (ii) Review and arrange for the billing of users. (2) The Associate...

  17. 14 CFR 1214.207 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... the STS Program § 1214.207 Responsibilities. (a) Headquarters officials. (1) The NASA Comptroller, in... the NASA Issuance System, and (ii) Review and arrange for the billing of users. (2) The Associate...

  18. 14 CFR 1214.207 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... the STS Program § 1214.207 Responsibilities. (a) Headquarters officials. (1) The NASA Comptroller, in... the NASA Issuance System, and (ii) Review and arrange for the billing of users. (2) The Associate...

  19. 14 CFR 1214.207 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Shuttle... the STS Program § 1214.207 Responsibilities. (a) Headquarters officials. (1) The NASA Comptroller, in... the NASA Issuance System, and (ii) Review and arrange for the billing of users. (2) The Associate...

  20. To fly or not to fly? The automatic influence of negation on language-space associations.

    PubMed

    Dudschig, Carolin; de la Vega, Irmgard; Kaup, Barbara

    2015-09-01

    Embodied models of language understanding propose a close association between language comprehension and sensorimotor processes. Specifically, they suggest that meaning representation is grounded in modal experiences. Converging evidence suggests that words automatically activate spatial processing. For example, words such as 'sky' ('ground') facilitate motor and visual processing associated with upper (lower) space. However, very little is known regarding the influence of linguistic operators such as negation on these language-space associations. If these associations play a crucial role for language understanding beyond the word level, one would expect linguistic operators to automatically influence or modify these language-space associations. Participants read sentences describing an event implying an upward or a downward motion in an affirmative or negated version (e.g. The granny looks to the sky/ground vs. The granny does not look to the sky/ground). Subsequently, participants responded with an upward or downward arm movement according to the colour of a dot on the screen. The results showed that the motion direction implied in the sentences influenced subsequent spatially directed motor responses. For affirmative sentences, arm movements were faster if they matched the movement direction implied in the sentence. This language-space association was modified by the negation operator. Our results show that linguistic operators--such as negation--automatically modify language-space associations. Thus, language-space associations seem to reflect language processes beyond pure word-based activations.

  1. NASA Space Technology Can Improve Soldier Health, Performance and Safety

    NASA Technical Reports Server (NTRS)

    Cowings, Patricia S.; Toscano, William B.

    2000-01-01

    One of the primary goals of NASA Life Sciences research is '... to enable a permanent human presence in space.' To meet this goal, NASA is creating alternative protocols designed to evaluate and test countermeasures that will account for and correct the environmental effects of space flight on crewmembers health, safety, and operational performance. NASA investigators have previously evaluated the effects of long-duration space flight on physiology and performance of cosmonauts aboard the MIR space station. They also initiated tests of a countermeasure, Autogenic-Feedback Training Exercise (AFTE) designed to prevent and/or correct adverse effects, i.e., facilitate adaptation to space and re-adaptation to Earth. AFTE is a six-hour physiological training program that has proven to be a highly efficient and effective method for enabling people to monitor and voluntarily control a range of their own physiological responses, thereby minimizing adverse reactions to environmental stress. However, because of limited opportunities to test this technology with space flight crews, it is essential to find operational or 'real world' environments in which to validate the efficacy of this approach.

  2. Chromosome Aberrations in Astronauts

    NASA Technical Reports Server (NTRS)

    George, Kerry A.; Durante, M.; Cucinotta, Francis A.

    2007-01-01

    A review of currently available data on in vivo induced chromosome damage in the blood lymphocytes of astronauts proves that, after protracted exposure of a few months or more to space radiation, cytogenetic biodosimetry analyses of blood collected within a week or two of return from space provides a reliable estimate of equivalent radiation dose and risk. Recent studies indicate that biodosimetry estimates from single spaceflights lie within the range expected from physical dosimetry and biophysical models, but very large uncertainties are associated with single individual measurements and the total sample population remains low. Retrospective doses may be more difficult to estimate because of the fairly rapid time-dependent loss of "stable" aberrations in blood lymphocytes. Also, biodosimetry estimates from individuals who participate in multiple missions, or very long (interplanetary) missions, may be complicated by an adaptive response to space radiation and/or changes in lymphocyte survival and repopulation. A discussion of published data is presented and specific issues related to space radiation biodosimetry protocols are discussed.

  3. Motor and linguistic linking of space and time in the cerebellum.

    PubMed

    Oliveri, Massimiliano; Bonnì, Sonia; Turriziani, Patrizia; Koch, Giacomo; Lo Gerfo, Emanuele; Torriero, Sara; Vicario, Carmelo Mario; Petrosini, Laura; Caltagirone, Carlo

    2009-11-20

    Recent literature documented the presence of spatial-temporal interactions in the human brain. The aim of the present study was to verify whether representation of past and future is also mapped onto spatial representations and whether the cerebellum may be a neural substrate for linking space and time in the linguistic domain. We asked whether processing of the tense of a verb is influenced by the space where response takes place and by the semantics of the verb. Responses to past tense were facilitated in the left space while responses to future tense were facilitated in the right space. Repetitive transcranial magnetic stimulation (rTMS) of the right cerebellum selectively slowed down responses to future tense of action verbs; rTMS of both cerebellar hemispheres decreased accuracy of responses to past tense in the left space and to future tense in the right space for non-verbs, and to future tense in the right space for state verbs. The results suggest that representation of past and future is mapped onto spatial formats and that motor action could represent the link between spatial and temporal dimensions. Right cerebellar, left motor brain networks could be part of the prospective brain, whose primary function is to use past experiences to anticipate future events. Both cerebellar hemispheres could play a role in establishing the grammatical rules for verb conjugation.

  4. 41 CFR 301-70.903 - What are our responsibilities for ensuring that Government aircraft are the most cost-effective...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... governmental function or for required use travel, using any space available for passengers on official travel... responsibilities for ensuring that Government aircraft are the most cost-effective alternative for travel? 301-70.903 Section 301-70.903 Public Contracts and Property Management Federal Travel Regulation System...

  5. 41 CFR 301-70.903 - What are our responsibilities for ensuring that Government aircraft are the most cost-effective...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... governmental function or for required use travel, using any space available for passengers on official travel... responsibilities for ensuring that Government aircraft are the most cost-effective alternative for travel? 301-70.903 Section 301-70.903 Public Contracts and Property Management Federal Travel Regulation System...

  6. 41 CFR 301-70.903 - What are our responsibilities for ensuring that Government aircraft are the most cost-effective...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... governmental function or for required use travel, using any space available for passengers on official travel... responsibilities for ensuring that Government aircraft are the most cost-effective alternative for travel? 301-70.903 Section 301-70.903 Public Contracts and Property Management Federal Travel Regulation System...

  7. 41 CFR 301-70.903 - What are our responsibilities for ensuring that Government aircraft are the most cost-effective...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... governmental function or for required use travel, using any space available for passengers on official travel... responsibilities for ensuring that Government aircraft are the most cost-effective alternative for travel? 301-70.903 Section 301-70.903 Public Contracts and Property Management Federal Travel Regulation System...

  8. 41 CFR 301-70.903 - What are our responsibilities for ensuring that Government aircraft are the most cost-effective...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... governmental function or for required use travel, using any space available for passengers on official travel... responsibilities for ensuring that Government aircraft are the most cost-effective alternative for travel? 301-70.903 Section 301-70.903 Public Contracts and Property Management Federal Travel Regulation System...

  9. Expression of stress/defense-related genes in barley grown under space environment

    NASA Astrophysics Data System (ADS)

    Sugimoto, Manabu; Shagimardanova, Elena; Gusev, Oleg; Bingham, Gail; Levinskikh, Margarita; Sychev, Vladimir

    Plants are exposed to the extreme environment in space, especially space radiation is suspected to induce oxidative stress by generating high-energy free radicals and microgravity would enhance the effect of space radiation, however, current understandings of plant growth and responses on this synergistic effect of radiation and microgravity is limited to a few experiments. In this study, expression of stress/defense-related genes in barley grown under space environment was analyzed by RT-PCR and DNA microarray experiments to understand plant responses and adaptation to space environment and to develop the space stress-tolerant plants. The seeds of barley, Hordeum vulgare L. cv. Haruna nijo, kept in the international space station (ISS) over 4 months, were germinated after 3 days of irrigation in LADA plant growth chamber onboard Russian segment of ISS and the final germination ratio was over 90 %. The height of plants was about 50 to 60 cm and flag leaf has been opened after 26 days of irrigation under 24 hr lighting, showing the similar growth to ground-grown barley. Expression levels of stress/defense-related genes in space-grown barley were compared to those in ground-grown barley by semi-quantitative RT-PCR. In 17 stress/defense-related genes that are up-regulated by oxidative stress or other abiotic stress, only catalase, pathogenesis-related protein 13, chalcone synthase, and phenylalanine ammonia-lyase genes were increased in space-grown barley. DNA microarrya analysis with the GeneChip Barley Genome Array showed the similar expression profiles of the stress/defense-related genes to those by RT-PCR experiment, suggesting that the barley germinated and grown in LADA onboard ISS is not damaged by space environment, especially oxidative stress induced by space radiation and microgravity.

  10. Response-based Multimedia and the Culture of the Classroom: A Pilot Study of "Kid's Space" in Four Elementary Classrooms. Report Series 2.26.

    ERIC Educational Resources Information Center

    Meskill, Carla; Swan, Karen

    A pilot study describes the prototype design and classroom implementation of "Kid's Space," a response-based multimedia application for literature teaching and learning. "Kid's Space" was designed around the metaphor of a universe populated by the individual student's world. Each world supports a variety of personal spaces in…

  11. International Space Station (ISS)

    NASA Image and Video Library

    2001-02-01

    The Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. Scientists and engineers at the MSFC are working together to provide the ISS with systems that are safe, efficient, and cost-effective. These compact and powerful systems are collectively called the Environmental Control and Life Support Systems, or simply, ECLSS. This photograph shows the development Water Processor located in two racks in the ECLSS test area at the Marshall Space Flight Center. Actual waste water, simulating Space Station waste, is generated and processed through the hardware to evaluate the performance of technologies in the flight Water Processor design.

  12. Effects of Initial Geometric Imperfections On the Non-Linear Response of the Space Shuttle Superlightweight Liquid-Oxygen Tank

    NASA Technical Reports Server (NTRS)

    Nemeth, Michael P.; Young, Richard D.; Collins, Timothy J.; Starnes, James H., Jr.

    2002-01-01

    The results of an analytical study of the elastic buckling and nonlinear behavior of the liquid-oxygen tank for the new Space Shuttle superlightweight external fuel tank are presented. Selected results that illustrate three distinctly different types of non-linear response phenomena for thin-walled shells which are subjected to combined mechanical and thermal loads are presented. These response phenomena consist of a bifurcation-type buckling response, a short-wavelength non-linear bending response and a non-linear collapse or "snap-through" response associated with a limit point. The effects of initial geometric imperfections on the response characteristics are emphasized. The results illustrate that the buckling and non-linear response of a geometrically imperfect shell structure subjected to complex loading conditions may not be adequately characterized by an elastic linear bifurcation buckling analysis, and that the traditional industry practice of applying a buckling-load knock-down factor can result in an ultraconservative design. Results are also presented that show that a fluid-filled shell can be highly sensitive to initial geometric imperfections, and that the use a buckling-load knock-down factor is needed for this case.

  13. Tunnel effect measuring systems and particle detectors

    NASA Technical Reports Server (NTRS)

    Kaiser, William J. (Inventor); Waltman, Steven B. (Inventor); Kenny, Thomas W. (Inventor)

    1994-01-01

    Methods and apparatus for measuring gravitational and inertial forces, magnetic fields, or wave or radiant energy acting on an object or fluid in space provide an electric tunneling current through a gap between an electrode and that object or fluid in space and vary that gap with any selected one of such forces, magnetic fields, or wave or radiant energy acting on that object or fluid. These methods and apparatus sense a corresponding variation in an electric property of that gap and determine the latter force, magnetic fields, or wave or radiant energy in response to that corresponding variation, and thereby sense or measure such parameters as acceleration, position, particle mass, velocity, magnetic field strength, presence or direction, or wave or radiant energy intensity, presence or direction.

  14. Tunnel effect measuring systems and particle detectors

    NASA Technical Reports Server (NTRS)

    Kaiser, William J. (Inventor); Waltman, Steven B. (Inventor); Kenny, Thomas W. (Inventor)

    1993-01-01

    Methods and apparatus for measuring gravitational and inertial forces, magnetic fields, or wave or radiant energy acting on an object or fluid in space provide an electric tunneling current through a gap between an electrode and that object or fluid in space and vary that gap with any selected one of such forces, magnetic fields, or wave or radiant energy acting on that object or fluid. These methods and apparatus sense a corresponding variation in an electric property of that gap and determine the latter force, magnetic fields, or wave or radiant energy in response to that corresponding variation, and thereby sense or measure such parameters as acceleration, position, particle mass, velocity, magnetic field strength, presence or direction, or wave or radiant energy intensity, presence or direction.

  15. Tunnel effect wave energy detection

    NASA Technical Reports Server (NTRS)

    Kaiser, William J. (Inventor); Waltman, Steven B. (Inventor); Kenny, Thomas W. (Inventor)

    1995-01-01

    Methods and apparatus for measuring gravitational and inertial forces, magnetic fields, or wave or radiant energy acting on an object or fluid in space provide an electric tunneling current through a gap between an electrode and that object or fluid in space and vary that gap with any selected one of such forces, magnetic fields, or wave or radiant energy acting on that object or fluid. These methods and apparatus sense a corresponding variation in an electric property of that gap and determine the latter force, magnetic fields, or wave or radiant energy in response to that corresponding variation, and thereby sense or measure such parameters as acceleration, position, particle mass, velocity, magnetic field strength, presence or direction, or wave or radiant energy intensity, presence or direction.

  16. Biological and metabolic response in STS-135 space-flown mouse skin.

    PubMed

    Mao, X W; Pecaut, M J; Stodieck, L S; Ferguson, V L; Bateman, T A; Bouxsein, M L; Gridley, D S

    2014-08-01

    There is evidence that space flight condition-induced biological damage is associated with increased oxidative stress and extracellular matrix (ECM) remodeling. To explore possible mechanisms, changes in gene expression profiles implicated in oxidative stress and in ECM remodeling in mouse skin were examined after space flight. The metabolic effects of space flight in skin tissues were also characterized. Space Shuttle Atlantis (STS-135) was launched at the Kennedy Space Center on a 13-day mission. Female C57BL/6 mice were flown in the STS-135 using animal enclosure modules (AEMs). Within 3-5 h after landing, the mice were euthanized and skin samples were harvested for gene array analysis and metabolic biochemical assays. Many genes responsible for regulating production and metabolism of reactive oxygen species (ROS) were significantly (p < 0.05) altered in the flight group, with fold changes >1.5 compared to AEM control. For ECM profile, several genes encoding matrix and metalloproteinases involved in ECM remodeling were significantly up-/down-regulated following space flight. To characterize the metabolic effects of space flight, global biochemical profiles were evaluated. Of 332 named biochemicals, 19 differed significantly (p < 0.05) between space flight skin samples and AEM ground controls, with 12 up-regulated and 7 down-regulated including altered amino acid, carbohydrate metabolism, cell signaling, and transmethylation pathways. Collectively, the data demonstrated that space flight condition leads to a shift in biological and metabolic homeostasis as the consequence of increased regulation in cellular antioxidants, ROS production, and tissue remodeling. This indicates that astronauts may be at increased risk for pathophysiologic damage or carcinogenesis in cutaneous tissue.

  17. 14 CFR 417.9 - Launch site responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Launch site responsibility. 417.9 Section 417.9 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY General and License Terms and Conditions § 417.9 Launch...

  18. 14 CFR 417.9 - Launch site responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Launch site responsibility. 417.9 Section 417.9 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY General and License Terms and Conditions § 417.9 Launch...

  19. 14 CFR 1213.103 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Responsibilities. 1213.103 Section 1213.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND... news releases and other types of public information will be issued nationwide by NASA Headquarters...

  20. 14 CFR 1213.103 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Responsibilities. 1213.103 Section 1213.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND... news releases and other types of public information will be issued nationwide by NASA Headquarters...

  1. 14 CFR 1213.103 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Responsibilities. 1213.103 Section 1213.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND... news releases and other types of public information will be issued nationwide by NASA Headquarters...

  2. 14 CFR 1213.103 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Responsibilities. 1213.103 Section 1213.103 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND... news releases and other types of public information will be issued nationwide by NASA Headquarters...

  3. 14 CFR 437.81 - Public safety responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Public safety responsibility. 437.81 Section 437.81 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... an experimental permit is safe, and must protect public health and safety and the safety of property. ...

  4. 14 CFR 437.81 - Public safety responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Public safety responsibility. 437.81 Section 437.81 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... an experimental permit is safe, and must protect public health and safety and the safety of property. ...

  5. Human Adaptation to Space: Space Physiology and Countermeasures

    NASA Technical Reports Server (NTRS)

    Fogarty, Jennifer

    2009-01-01

    This viewgraph presentation reviews human physiological responses to spaceflight, and the countermeasures taken to prevent adverse effects of manned space flight. The topics include: 1) Human Spaceflight Experience; 2) Human Response to Spaceflight; 3) ISS Expeditions 1-16; 4) Countermeasure; and 5) Biomedical Data;

  6. A Constraint Based Approach for Building Operationally Responsive Satellites

    DTIC Science & Technology

    2008-09-01

    Analysis . . . . . . . . . . . . . . . . . . . 8 RST Responsive Space Testbed . . . . . . . . . . . . . . . . . . 9 HWIL Hardware - In - Loop . . . . . . . . . . . . . . . . . . . . . . 9...Responsive Space Satellite Cell in RST is configured to deliver the simulated environment to Hardware - In - Loop (HWIL) Device Under Test (DUT). As shown in

  7. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.

    PubMed

    Honda, Yoko; Higashibata, Akira; Matsunaga, Yohei; Yonezawa, Yukiko; Kawano, Tsuyoshi; Higashitani, Atsushi; Kuriyama, Kana; Shimazu, Toru; Tanaka, Masashi; Szewczyk, Nathaniel J; Ishioka, Noriaki; Honda, Shuji

    2012-01-01

    How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.

  8. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans

    PubMed Central

    Honda, Yoko; Higashibata, Akira; Matsunaga, Yohei; Yonezawa, Yukiko; Kawano, Tsuyoshi; Higashitani, Atsushi; Kuriyama, Kana; Shimazu, Toru; Tanaka, Masashi; Szewczyk, Nathaniel J.; Ishioka, Noriaki; Honda, Shuji

    2012-01-01

    How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues. PMID:22768380

  9. Uncertainty quantification for complex systems with very high dimensional response using Grassmann manifold variations

    NASA Astrophysics Data System (ADS)

    Giovanis, D. G.; Shields, M. D.

    2018-07-01

    This paper addresses uncertainty quantification (UQ) for problems where scalar (or low-dimensional vector) response quantities are insufficient and, instead, full-field (very high-dimensional) responses are of interest. To do so, an adaptive stochastic simulation-based methodology is introduced that refines the probability space based on Grassmann manifold variations. The proposed method has a multi-element character discretizing the probability space into simplex elements using a Delaunay triangulation. For every simplex, the high-dimensional solutions corresponding to its vertices (sample points) are projected onto the Grassmann manifold. The pairwise distances between these points are calculated using appropriately defined metrics and the elements with large total distance are sub-sampled and refined. As a result, regions of the probability space that produce significant changes in the full-field solution are accurately resolved. An added benefit is that an approximation of the solution within each element can be obtained by interpolation on the Grassmann manifold. The method is applied to study the probability of shear band formation in a bulk metallic glass using the shear transformation zone theory.

  10. COSMOS 2044 Mission: Overview

    NASA Technical Reports Server (NTRS)

    Grindeland, R. E.; Ballard, R. W.; Connol, J. P.; Vasques, M. F.

    1992-01-01

    The COSMOS 2044 spaceflight was the ninth Soviet-International joint mission dedicated to space biomedicine and the seventh in which the United States has participated. The unmanned Vostok vehicle carried 10 rats and two rhesus monkeys on its 14-day voyage. This spaceflight yielded an unprecedented bounty of data on physiological responses to the microgravity environment. The tissues studied and the numbers and types of studies performed by members of the international science community constituted a new record. Many of the results obtained by the approximately 80 American scientists who participated are reported in the series of COSMOS 2044 papers in this issue. Descriptions of the spaceflight and animal procedures are detailed elsewhere. The broad goals of the space biomedical program are threefold. The first is to characterize qualitatively and quantitatively the biological responses to the microgravity environment, be they adaptive or pathological. The second goal is to clarify the physiological-biochemical mechanisms mediating the responses to microgravity. The third goal of this program is to use the space environment as a tool to better understand adaptive and disease processes in terrestrial organisms.

  11. An analytic solution for numerical modeling validation in electromagnetics: the resistive sphere

    NASA Astrophysics Data System (ADS)

    Swidinsky, Andrei; Liu, Lifei

    2017-11-01

    We derive the electromagnetic response of a resistive sphere to an electric dipole source buried in a conductive whole space. The solution consists of an infinite series of spherical Bessel functions and associated Legendre polynomials, and follows the well-studied problem of a conductive sphere buried in a resistive whole space in the presence of a magnetic dipole. Our result is particularly useful for controlled-source electromagnetic problems using a grounded electric dipole transmitter and can be used to check numerical methods of calculating the response of resistive targets (such as finite difference, finite volume, finite element and integral equation). While we elect to focus on the resistive sphere in our examples, the expressions in this paper are completely general and allow for arbitrary source frequency, sphere radius, transmitter position, receiver position and sphere/host conductivity contrast so that conductive target responses can also be checked. Commonly used mesh validation techniques consist of comparisons against other numerical codes, but such solutions may not always be reliable or readily available. Alternatively, the response of simple 1-D models can be tested against well-known whole space, half-space and layered earth solutions, but such an approach is inadequate for validating models with curved surfaces. We demonstrate that our theoretical results can be used as a complementary validation tool by comparing analytic electric fields to those calculated through a finite-element analysis; the software implementation of this infinite series solution is made available for direct and immediate application.

  12. Overview of Photonic Materials for Application in Space Environments

    NASA Technical Reports Server (NTRS)

    Taylor, E. W.; Osinski, M.; Svimonishvili, Tengiz; Watson, M.; Bunton, P.; Pearson, S. D.; Bilbro, J.

    1999-01-01

    Future space systems will he based on components evolving from the development and refinement of new and existing photonic materials. Optically based sensors, inertial guidance, tracking systems, communications, diagnostics, imaging and high speed optical processing are but a few of the applications expected to widely utilize photonic materials. The response of these materials to space environment effects (SEE) such as spacecraft charging, orbital debris, atomic oxygen, ultraviolet irradiation, temperature and ionizing radiation will be paramount to ensuring successful space applications. The intent of this paper is to, address the latter two environments via a succinct comparison of the known sensitivities of selected photonic materials to the temperature and ionizing radiation conditions found in space and enhanced space environments Delineation of the known temperature and radiation induced responses in LiNbO3, AlGaN, AlGsAs,TeO2, Si:Ge, and several organic polymers are presented. Photonic materials are realizing rapid transition into applications for many proposed space components and systems including: optical interconnects, optical gyros, waveguide and spatial light modulators, light emitting diodes, lasers, optical fibers and fiber optic amplifiers. Changes to material parameters such as electrooptic coefficients, absorption coefficients, polarization, conductivity, coupling coefficients, diffraction efficiencies, and other pertinent material properties examined for thermo-optic and radiation induced effect. Conclusions and recommendations provide the reader with an understanding of the limitations or attributes of material choices for specific applications.

  13. CubeSat Packaged Electrospray Thruster Evaluation for Enhanced Operationally Responsive Space Capabilities

    DTIC Science & Technology

    2011-03-24

    These satellites can perform many missions including: close formation flying with other CubeSats, and possible docking with a large satellite to...in 2008 to fly on the NASA LISA mission. LISA, the Laser Interferometer Space Antenna, is a joint NASA–ESA mission to observe astrophysical and...for mass spectrometry of large organic molecules popularized the technology and made components such as needles or other components readily

  14. Statistical analysis of modeling error in structural dynamic systems

    NASA Technical Reports Server (NTRS)

    Hasselman, T. K.; Chrostowski, J. D.

    1990-01-01

    The paper presents a generic statistical model of the (total) modeling error for conventional space structures in their launch configuration. Modeling error is defined as the difference between analytical prediction and experimental measurement. It is represented by the differences between predicted and measured real eigenvalues and eigenvectors. Comparisons are made between pre-test and post-test models. Total modeling error is then subdivided into measurement error, experimental error and 'pure' modeling error, and comparisons made between measurement error and total modeling error. The generic statistical model presented in this paper is based on the first four global (primary structure) modes of four different structures belonging to the generic category of Conventional Space Structures (specifically excluding large truss-type space structures). As such, it may be used to evaluate the uncertainty of predicted mode shapes and frequencies, sinusoidal response, or the transient response of other structures belonging to the same generic category.

  15. Development of Rural Emergency Medical System (REMS) with Geospatial Technology in Malaysia

    NASA Astrophysics Data System (ADS)

    Ooi, W. H.; Shahrizal, I. M.; Noordin, A.; Nurulain, M. I.; Norhan, M. Y.

    2014-02-01

    Emergency medical services are dedicated services in providing out-of-hospital transport to definitive care or patients with illnesses and injuries. In this service the response time and the preparedness of medical services is of prime importance. The application of space and geospatial technology such as satellite navigation system and Geographical Information System (GIS) was proven to improve the emergency operation in many developed countries. In collaboration with a medical service NGO, the National Space Agency (ANGKASA) has developed a prototype Rural Emergency Medical System (REMS), focusing on providing medical services to rural areas and incorporating satellite based tracking module integrated with GIS and patience database to improve the response time of the paramedic team during emergency. With the aim to benefit the grassroots community by exploiting space technology, the project was able to prove the system concept which will be addressed in this paper.

  16. Maximizing information from space data resources: a case for expanding integration across research disciplines.

    PubMed

    Goswami, Nandu; Batzel, Jerry J; Clément, Gilles; Stein, T Peter; Hargens, Alan R; Sharp, M Keith; Blaber, Andrew P; Roma, Peter G; Hinghofer-Szalkay, Helmut G

    2013-07-01

    Regulatory systems are affected in space by exposure to weightlessness, high-energy radiation or other spaceflight-induced changes. The impact of spaceflight occurs across multiple scales and systems. Exploring such interactions and interdependencies via an integrative approach provides new opportunities for elucidating these complex responses. This paper argues the case for increased emphasis on integration, systematically archiving, and the coordination of past, present and future space and ground-based analogue experiments. We also discuss possible mechanisms for such integration across disciplines and missions. This article then introduces several discipline-specific reviews that show how such integration can be implemented. Areas explored include: adaptation of the central nervous system to space; cerebral autoregulation and weightlessness; modelling of the cardiovascular system in space exploration; human metabolic response to spaceflight; and exercise, artificial gravity, and physiologic countermeasures for spaceflight. In summary, spaceflight physiology research needs a conceptual framework that extends problem solving beyond disciplinary barriers. Administrative commitment and a high degree of cooperation among investigators are needed to further such a process. Well-designed interdisciplinary research can expand opportunities for broad interpretation of results across multiple physiological systems, which may have applications on Earth.

  17. Historical Study of Radiation Exposures and the Incidence of Cataracts in Astronauts

    NASA Technical Reports Server (NTRS)

    Cucinotta, F. A.; Manuel, F. K.; Iszard, G.; Feiveson, A.; Peterson, L. E.; Hardy, D.; Marak, L.; Tung, W.; Wear, M.; Chylack, L. T., Jr.

    2004-01-01

    For over 35 years, astronauts in low Earth orbit or on missions to the moon have been exposed to space radiation comprised of high-energy protons, heavy ions, and secondary neutrons. We reviewed the radiation exposures received by astronauts in space and on Earth, and presented results from the first epidemiological study of cataract incidence in the astronauts. Our data suggested an increased risk for cataracts from space radiation exposures. Using parametric survival analysis and the maximum likelihood method, we estimated the dose-response and age distribution for cataract incidence in astronauts by space radiation. Considering the high-LET dose contributions on specific space missions as well as data from animal studies with neutrons and heavy ions, suggested a linear response with no dose-threshold for cataracts. However, there are unanswered questions related to the importance and the definition of clinically significant cataracts commonly used in radiation protection, especially in light of epidemiological data suggesting that the probability that sub-clinical cataracts will progress is highly dependent on the age at which cataracts appear. We briefly describe a new study that will address the measurement of cataract progression-rates in astronauts and a ground-based comparison group.

  18. Historical Study of Radiation Exposures and the Incidence of Cataracts in Astronauts

    NASA Technical Reports Server (NTRS)

    Cucinotta, F. A.; Manuel, F. K.; Iszard, G.; Feiveson, A.; Peterson, L. E.; Hardy, D.; Marak, L.; Tung, W.; Wear, M.; Chylack, L. T., Jr.

    2004-01-01

    For over 35 years, astronauts in low Earth orbit or on missions to the moon have been exposed to space radiation comprised of high-energy protons, heavy ions, and secondary neutrons. We reviewed the radiation exposures received by astronauts in space and on Earth, and presented results from the first epidemiological study of cataract incidence in the astronauts. Our data suggested an increased risk for cataracts from space radiation exposures*. Using parametric survival analysis and the maximum likelihood method, we estimated the dose-response and age distribution for cataract incidence in astronauts by space radiation. Considering the high-LET dose contributions on specific space missions as well as data from animal studies with neutrons and heavy ions, suggested a linear response with no dose-threshold for cataracts. However, there are unanswered questions related to the importance and the definition of "clinically significant" cataracts commonly used in radiation protection, especially in light of epidemiological data suggesting that the probability that "sub-clinical" cataracts will progress is highly dependent on the age at which cataracts appear. We briefly describe a new study that will address the measurement of cataract progression-rates in astronauts and a ground-based comparison group.

  19. 14 CFR 1274.933 - Summary of recipient reporting responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Summary of recipient reporting responsibilities. 1274.933 Section 1274.933 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION...—Retention by the Recipient (Small Business)(Paragraph (h)) Notice of Proposed Transfer of Technology Prior...

  20. 14 CFR 1274.933 - Summary of recipient reporting responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Summary of recipient reporting responsibilities. 1274.933 Section 1274.933 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION...—Retention by the Recipient (Small Business)(Paragraph (h)) Notice of Proposed Transfer of Technology Prior...

  1. 14 CFR 1274.933 - Summary of recipient reporting responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Summary of recipient reporting responsibilities. 1274.933 Section 1274.933 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION...—Retention by the Recipient (Small Business)(Paragraph (h)) Notice of Proposed Transfer of Technology Prior...

  2. 14 CFR 1212.700 - NASA employees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false NASA employees. 1212.700 Section 1212.700 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.700 NASA employees. (a) Each NASA employee is responsible for adhering...

  3. 14 CFR 1212.700 - NASA employees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true NASA employees. 1212.700 Section 1212.700 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.700 NASA employees. (a) Each NASA employee is responsible for adhering...

  4. 14 CFR 1212.700 - NASA employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false NASA employees. 1212.700 Section 1212.700 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.700 NASA employees. (a) Each NASA employee is responsible for adhering...

  5. 14 CFR 1212.700 - NASA employees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false NASA employees. 1212.700 Section 1212.700 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.700 NASA employees. (a) Each NASA employee is responsible for adhering...

  6. Probabilistic structural analysis methods for space transportation propulsion systems

    NASA Technical Reports Server (NTRS)

    Chamis, C. C.; Moore, N.; Anis, C.; Newell, J.; Nagpal, V.; Singhal, S.

    1991-01-01

    Information on probabilistic structural analysis methods for space propulsion systems is given in viewgraph form. Information is given on deterministic certification methods, probability of failure, component response analysis, stress responses for 2nd stage turbine blades, Space Shuttle Main Engine (SSME) structural durability, and program plans. .

  7. When the going gets tough: behavioural type-dependent space use in the sleepy lizard changes as the season dries

    PubMed Central

    Spiegel, Orr; Leu, Stephan T.; Sih, Andrew; Godfrey, Stephanie S.; Bull, C. Michael

    2015-01-01

    Understanding space use remains a major challenge for animal ecology, with implications for species interactions, disease spread, and conservation. Behavioural type (BT) may shape the space use of individuals within animal populations. Bolder or more aggressive individuals tend to be more exploratory and disperse further. Yet, to date we have limited knowledge on how space use other than dispersal depends on BT. To address this question we studied BT-dependent space-use patterns of sleepy lizards (Tiliqua rugosa) in southern Australia. We combined high-resolution global positioning system (GPS) tracking of 72 free-ranging lizards with repeated behavioural assays, and with a survey of the spatial distributions of their food and refuge resources. Bayesian generalized linear mixed models (GLMM) showed that lizards responded to the spatial distribution of resources at the neighbourhood scale and to the intensity of space use by other conspecifics (showing apparent conspecific avoidance). BT (especially aggressiveness) affected space use by lizards and their response to ecological and social factors, in a seasonally dependent manner. Many of these effects and interactions were stronger later in the season when food became scarce and environmental conditions got tougher. For example, refuge and food availability became more important later in the season and unaggressive lizards were more responsive to these predictors. These findings highlight a commonly overlooked source of heterogeneity in animal space use and improve our mechanistic understanding of processes leading to behaviourally driven disease dynamics and social structure. PMID:26609082

  8. Decoding and reconstructing color from responses in human visual cortex.

    PubMed

    Brouwer, Gijs Joost; Heeger, David J

    2009-11-04

    How is color represented by spatially distributed patterns of activity in visual cortex? Functional magnetic resonance imaging responses to several stimulus colors were analyzed with multivariate techniques: conventional pattern classification, a forward model of idealized color tuning, and principal component analysis (PCA). Stimulus color was accurately decoded from activity in V1, V2, V3, V4, and VO1 but not LO1, LO2, V3A/B, or MT+. The conventional classifier and forward model yielded similar accuracies, but the forward model (unlike the classifier) also reliably reconstructed novel stimulus colors not used to train (specify parameters of) the model. The mean responses, averaged across voxels in each visual area, were not reliably distinguishable for the different stimulus colors. Hence, each stimulus color was associated with a unique spatially distributed pattern of activity, presumably reflecting the color selectivity of cortical neurons. Using PCA, a color space was derived from the covariation, across voxels, in the responses to different colors. In V4 and VO1, the first two principal component scores (main source of variation) of the responses revealed a progression through perceptual color space, with perceptually similar colors evoking the most similar responses. This was not the case for any of the other visual cortical areas, including V1, although decoding was most accurate in V1. This dissociation implies a transformation from the color representation in V1 to reflect perceptual color space in V4 and VO1.

  9. Spaceflight and immune responses of Rhesus monkeys

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, Gerald

    1994-01-01

    Evidence from both human and rodent studies indicates that alterations in immunological parameters occur after space flight. The objective of this project is to determine the effects of space flight on immune responses of Rhesus monkeys. The expected significance of the work is a determination of the range of immunological functions of the Rhesus monkey, a primate similar in many ways to man, affected by space flight. Changes in immune responses that could yield alterations in resistance to infection may be determined as well as the duration of alterations in immune responses. Additional information on the nature of cellular interactions for the generation of immune responses may also be obtained.

  10. How family physicians respond to unpleasant emotions of ethnic minority patients.

    PubMed

    Aelbrecht, Karolien; De Maesschalck, Stéphanie; Willems, Sara; Deveugele, Myriam; Pype, Peter

    2017-10-01

    The diversity in our society makes patient-centered care more difficult. In this study, we aim to describe how family physicians respond to unpleasant emotions of ethnic minority patients. One hundred ninety one consultations of family physicians with ethnic minority patients were video-recorded and analyzed using the Verona Codes for Provider Responses (VR-CoDES-P) to describe physicians' responses to patients' expressed unpleasant emotions or cues (implicit) and concerns (explicit). 42.4% (n=81) of all the consultations contained no cues or concerns, and thus no physician responses. Of the consultations containing at least one cue or concern, a mean of 3.45 cues and a mean of 1.82 concerns per consultation were found. Physicians are significantly (p≤0.001) more frequently stimulating further disclosure of patients' cues and concerns (providing space: n=339/494 or 68.6% versus reducing space: n=155/494 or 31.4%). However, these explorations are more often about the factual, medical content of the cue than about the emotion itself (n=110/494 or 22.3% versus n=79/494 or 16%). The inter-physician variation in response to patients' cues is larger than the variation in response to the patient's concerns. Although family physicians are quite often providing room for patients' emotions, there is much room for improvement when it comes to explicitly talking about emotional issues with patients. Further research should focus on a more qualitative in-depth analysis of the complex interplay between culture and language of ethnic minority patients in primary care and, consequently, create awareness among these healthcare providers about the importance of ethnic minority patients' emotions and how to respond accordingly. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. The effects of space relevant environmental factors on halophilic Archaea

    NASA Astrophysics Data System (ADS)

    Leuko, Stefan; Moeller, Ralf; Rettberg, Petra

    Within the last 50 years, space technology has provided tools for transporting terrestrial (microbial) life beyond Earth's protective shield in order to study its responses to selected conditions of space. Microorganisms are ubiquitous and can be found in almost every environment on Earth. They thrive and survive in a broad spectrum of environments and are true masters in adapting to rapidly changing external conditions. Although microorganisms cannot actively grow under the harsh conditions of outer space or other known planets, some microorganisms might be able to survive for a time in space or other planets as dormant, inactive spores or in similar desiccation-resistant resting states, e.g., enclosed in halite crystals or biofilms. Halite crystals are the realm of halophilic Archaea as they have adapted to life at extreme salt concentrations. They can stay entrapped in such crystals for millions of years without losing viability and therefore the family Halobacteriaceae belongs to the group of microorganisms which may survive space travel or may even be found on other planets. Several members of this family have been utilized in space relevant experiments where they were exposed to detrimental environmental conditions such as UV-C radiation, vacuum, temperature cycles (+60(°) C and -25(°) C) and heavy iron bombardment (150 MeV He, 500 MeV Ar and 500 MeV Fe ions). The viability was evaluated by colony forming unit (cfu) counts as well as with the LIFE/DEAD kit. Results revealed that UV-C radiation (up to 1.000 J/m (2) ) has a considerable effect on the viability, whereas the other tested parameters inflict little damage onto the organisms. Repair of UV-C inflicted damage is efficient and several DNA damage repair genes are up-regulated following exposure. Halophilic archaea display a strong resistance against heavy iron bombardment, with dosages of up to 2.000 Gy 500 MeV Fe ions needed to establish a visible effect on the vitality. Genomic integrity after exposure was investigated by several different methods e.g. RAPD - PCR, a technique that elucidates damages within the genome by different amplification patterns. Overall experimental results indicate that halophilic Archaea are able to withstand the exposure to space related environmental factors for a considerable time. This work in combined with others will lead to a detailed understanding of the response of extraterrestrial conditions to halophilic Archaea for astrobiological considerations.

  12. Towards AN Integrated Scientific and Social Case for Human Space Exploration

    NASA Astrophysics Data System (ADS)

    Crawford, I. A.

    2004-06-01

    I will argue that an ambitious programme of human space exploration, involving a return to the Moon, and eventually human missions to Mars, will add greatly to human knowledge. Gathering such knowledge is the primary aim of science, but science’s compartmentalisation into isolated academic disciplines tends to obscure the overall strength of the scientific case. Any consideration of the scientific arguments for human space exploration must therefore take a holistic view, and integrate the potential benefits over the entire spectrum of human knowledge. Moreover, science is only one thread in a much larger overall case for human space exploration. Other threads include economic, industrial, educational, geopolitical and cultural benefits. Any responsibly formulated public space policy must weigh all of these factors before deciding whether or not an investment in human space activities is scientifically and socially desirable.

  13. Physiological Stress and Refuge Behavior by African Elephants

    PubMed Central

    Jachowski, David S.; Slotow, Rob; Millspaugh, Joshua J.

    2012-01-01

    Physiological stress responses allow individuals to adapt to changes in their status or surroundings, but chronic exposure to stressors could have detrimental effects. Increased stress hormone secretion leads to short-term escape behavior; however, no studies have assessed the potential of longer-term escape behavior, when individuals are in a chronic physiological state. Such refuge behavior is likely to take two forms, where an individual or population restricts its space use patterns spatially (spatial refuge hypothesis), or alters its use of space temporally (temporal refuge hypothesis). We tested the spatial and temporal refuge hypotheses by comparing space use patterns among three African elephant populations maintaining different fecal glucocorticoid metabolite (FGM) concentrations. In support of the spatial refuge hypothesis, the elephant population that maintained elevated FGM concentrations (iSimangaliso) used 20% less of its reserve than did an elephant population with lower FGM concentrations (Pilanesberg) in a reserve of similar size, and 43% less than elephants in the smaller Phinda reserve. We found mixed support for the temporal refuge hypothesis; home range sizes in the iSimangaliso population did not differ by day compared to nighttime, but elephants used areas within their home ranges differently between day and night. Elephants in all three reserves generally selected forest and woodland habitats over grasslands, but elephants in iSimangaliso selected exotic forest plantations over native habitat types. Our findings suggest that chronic stress is associated with restricted space use and altered habitat preferences that resemble a facultative refuge behavioral response. Elephants can maintain elevated FGM levels for ≥6 years following translocation, during which they exhibit refuge behavior that is likely a result of human disturbance and habitat conditions. Wildlife managers planning to translocate animals, or to initiate other management activities that could result in chronic stress responses, should consider the potential for, and consequences of, refuge behavior. PMID:22384079

  14. Space Shuttle Project

    NASA Image and Video Library

    1981-01-01

    A Space Shuttle Main Engine undergoes test-firing at the National Space Technology Laboratories (now the Sternis Space Center) in Mississippi. The Marshall Space Flight Center had management responsibility of Space Shuttle propulsion elements, including the Main Engines.

  15. 14 CFR 1251.106 - Designation of responsible employee and adoption of grievance procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Designation of responsible employee and adoption of grievance procedures. 1251.106 Section 1251.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.106 Designation of...

  16. 14 CFR 1251.106 - Designation of responsible employee and adoption of grievance procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Designation of responsible employee and adoption of grievance procedures. 1251.106 Section 1251.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.106 Designation of...

  17. 14 CFR 1251.106 - Designation of responsible employee and adoption of grievance procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Designation of responsible employee and adoption of grievance procedures. 1251.106 Section 1251.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.106 Designation of...

  18. 14 CFR 1251.106 - Designation of responsible employee and adoption of grievance procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Designation of responsible employee and adoption of grievance procedures. 1251.106 Section 1251.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.106 Designation of...

  19. 14 CFR § 1212.700 - NASA employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false NASA employees. § 1212.700 Section § 1212.700 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.700 NASA employees. (a) Each NASA employee is responsible...

  20. Training and Tactical Operationally Responsive Space Operations

    NASA Astrophysics Data System (ADS)

    Sorensen, B.; Strunce, R., Jr.

    Current space assets managed by traditional space system control resources provide communication, navigation, intelligence, surveillance, and reconnaissance (ISR) capabilities using satellites that are designed for long life and high reliability. The next generation Operationally Responsive Space (ORS) systems are aimed at providing operational space capabilities which will provide flexibility and responsiveness to the tactical battlefield commander. These capabilities do not exist today. The ORS communication, navigation, and ISR satellites are being designed to replace or supplement existing systems in order to enhance the current space force. These systems are expected to rapidly meet near term space needs of the tactical forces. The ORS concept includes new tactical satellites specifically designed to support contingency operations such as increased communication bandwidth and ISR imagery over the theater for a limited period to support air, ground, and naval force mission. The Concept of Operations (CONOPS) that exists today specifies that in addition to operational control of the satellite, the tasking and scheduling of the ORS tactical satellite for mission data collection in support of the tactical warfighter will be accomplished within the Virtual Mission Operations Center (VMOC). This is very similar to what is currently being accomplished in a fixed Mission Operations Center on existing traditional ISR satellites. The VMOC is merely a distributed environment and the CONOPS remain virtually the same. As a result, there is a significant drawback to the current ORS CONOPS that does not account for the full potential of the ORS paradigm for supporting tactical forces. Although the CONOPS approach may be appropriate for experimental Tactical Satellites (TacSat), it ignores the issues associated with the In-Theater Commander's need to own and operate his dedicated TacSat for most effective warfighting as well as the Warfighter specific CONOPS. What is needed to realize the full potential of the ORS approach to the support of in-theater tactical forces is the development of satellite tasking, interface, and data retrieval capabilities and mission operations approaches from a warfighter centered perspective, and the development of realistic training and simulation capabilities that will allow development, demonstration, and assessment of ORS tactical CONOPS. A system for Training and Tactical ORS Operations (TATOO) is currently being developed. This system will support development and evaluation of ORS specific CONOPS approaches, and training and evaluation of those CONOPS implementations through dedicated training capabilities, facilities, and exercises. TATOO will support the operational side of ORS and will merge with the revolutionary ORS spacecraft development and deployment processes to make the ORS paradigm a reality. TATOO's primary objective is to support the In-Theater Commander and Warfighter by developing, training, and assessing ORS mission CONOPS for In-Theater tasking, scheduling, interface, and data retrieval for TacSats owned by In-Theater Commanders. TATOO provides a laboratory/classroom environment for the development, test and evaluation of ORS Tactical Mission CONOPS for In-Theater ORS operations. The TATOO laboratory will also be used to develop, evaluate, and document ORS Mission CONOPS for tactical ISR and other ORS missions. Within this framework, the laboratory/classroom can be used to develop the necessary training materials and procedures, as well as conduct training exercises that emphasize the training of In-Theater personal with regard to: Tactical Ground Station Mission Operations; Tactical Operations for Mission Tasking and Scheduling; Tactical Mission Data Retrieval; and, Support for Warfighter Operations.

  1. Emotional valence and physical space: limits of interaction.

    PubMed

    de la Vega, Irmgard; de Filippis, Mónica; Lachmair, Martin; Dudschig, Carolin; Kaup, Barbara

    2012-04-01

    According to the body-specificity hypothesis, people associate positive things with the side of space that corresponds to their dominant hand and negative things with the side corresponding to their nondominant hand. Our aim was to find out whether this association holds also true for a response time study using linguistic stimuli, and whether such an association is activated automatically. Four experiments explored this association using positive and negative words. In Exp. 1, right-handers made a lexical judgment by pressing a left or right key. Attention was not explicitly drawn to the valence of the stimuli. No valence-by-side interaction emerged. In Exp. 2 and 3, right-handers and left-handers made a valence judgment by pressing a left or a right key. A valence-by-side interaction emerged: For positive words, responses were faster when participants responded with their dominant hand, whereas for negative words, responses were faster for the nondominant hand. Exp. 4 required a valence judgment without stating an explicit mapping of valence and side. No valence-by-side interaction emerged. The experiments provide evidence for an association between response side and valence, which, however, does not seem to be activated automatically but rather requires a task with an explicit response mapping to occur.

  2. The Aging Urban Brain: Analyzing Outdoor Physical Activity Using the Emotiv Affectiv Suite in Older People.

    PubMed

    Neale, Chris; Aspinall, Peter; Roe, Jenny; Tilley, Sara; Mavros, Panagiotis; Cinderby, Steve; Coyne, Richard; Thin, Neil; Bennett, Gary; Thompson, Catharine Ward

    2017-12-01

    This research directly assesses older people's neural activation in response to a changing urban environment while walking, as measured by electroencephalography (EEG). The study builds on previous research that shows changes in cortical activity while moving through different urban settings. The current study extends this methodology to explore previously unstudied outcomes in older people aged 65 years or more (n = 95). Participants were recruited to walk one of six scenarios pairing urban busy (a commercial street with traffic), urban quiet (a residential street) and urban green (a public park) spaces in a counterbalanced design, wearing a mobile Emotiv EEG headset to record real-time neural responses to place. Each walk lasted around 15 min and was undertaken at the pace of the participant. We report on the outputs for these responses derived from the Emotiv Affectiv Suite software, which creates emotional parameters ('excitement', 'frustration', 'engagement' and 'meditation') with a real-time value assigned to them. The six walking scenarios were compared using a form of high dimensional correlated component regression (CCR) on difference data, capturing the change between one setting and another. The results showed that levels of 'engagement' were higher in the urban green space compared to those of the urban busy and urban quiet spaces, whereas levels of 'excitement' were higher in the urban busy environment compared with those of the urban green space and quiet urban space. In both cases, this effect is shown regardless of the order of exposure to these different environments. These results suggest that there are neural signatures associated with the experience of different urban spaces which may reflect the older age of the sample as well as the condition of the spaces themselves. The urban green space appears to have a restorative effect on this group of older adults.

  3. Comparison of cardiovascular function during the early hours of bed rest and space flight

    NASA Technical Reports Server (NTRS)

    Lathers, C. M.; Charles, J. B.

    1994-01-01

    This paper reviews the cardiovascular responses of six healthy male subjects to 6 hours in a 5 degrees head-down bed rest model of weightlessness, and compares these responses to those obtained when subjects were positioned in head-up tilts of 10 degrees, 20 degrees, and 42 degrees, simulating 1/6, 1/3, and 2/3 G, respectively. Thoracic fluid index, cardiac output, stroke volume, and peak flow were measured using impedance cardiography. Cardiac dimensions and volumes were determined from two-dimensional guided M-mode echocardiograms in the left lateral decubitus position at 0, 2, 4, and 6 hours. Cardiovascular response to a stand test were compared before and after bed rest. The impedance values were related to tilt angle for the first 2 hours of tilt; however, after 3 hours, at all four angles, values began to converge, indicating that cardiovascular homeostatic mechanisms seek a common adapted state, regardless of effective gravity level (tilt angle) up to 2/3 G. Echocardiography revealed that left ventricular end-diastolic and end-systolic volume, stroke volume, ejection fraction, heart rate, and cardiac output had returned to control values by hour 6 for all tilt angles. The lack of a significant immediate change in left ventricular end-diastolic volume, despite decrements in stroke volume (P < .05) and heart rate (not significant), indicates that multiple factors may play a role in the adaptation to simulated hypogravity. The echocardiography data indicated that no angle of tilt, whether head-down or head-up for 4 to 6 hours, mimicked exactly the changes in cardiovascular function recorded after 4 to 6 hours of space flight. Changes in left ventricular end-diastolic volume during space flight and tilt may be similar, but follow a different time course. Nevertheless, head-down tilt at 5 degrees for 6 hours mimics some (stroke volume, systolic and diastolic blood pressure, mean arterial blood pressure, and total resistance), but not all, of the changes occurring in an equivalent time of space flight. The magnitude of the change in the mean heart rate response to standing was greater after six hours of tilt at -5 degrees or 10 degrees. Thus, results from the stand test after 6 hours of bed rest at -5 degrees and 10 degrees, but not at 20 degrees or 42 degrees, are similar to those obtained after space flight.

  4. Balancing novelty with confined chemical space in modern drug discovery.

    PubMed

    Medina-Franco, José L; Martinez-Mayorga, Karina; Meurice, Nathalie

    2014-02-01

    The concept of chemical space has broad applications in drug discovery. In response to the needs of drug discovery campaigns, different approaches are followed to efficiently populate, mine and select relevant chemical spaces that overlap with biologically relevant chemical spaces. This paper reviews major trends in current drug discovery and their impact on the mining and population of chemical space. We also survey different approaches to develop screening libraries with confined chemical spaces balancing physicochemical properties. In this context, the confinement is guided by criteria that can be divided in two broad categories: i) library design focused on a relevant therapeutic target or disease and ii) library design focused on the chemistry or a desired molecular function. The design and development of chemical libraries should be associated with the specific purpose of the library and the project goals. The high complexity of drug discovery and the inherent imperfection of individual experimental and computational technologies prompt the integration of complementary library design and screening approaches to expedite the identification of new and better drugs. Library design approaches including diversity-oriented synthesis, biological-oriented synthesis or combinatorial library design, to name a few, and the design of focused libraries driven by target/disease, chemical structure or molecular function are more efficient if they are guided by multi-parameter optimization. In this context, consideration of pharmaceutically relevant properties is essential for balancing novelty with chemical space in drug discovery.

  5. PLATSIM: A Simulation and Analysis Package for Large-Order Flexible Systems. Version 2.0

    NASA Technical Reports Server (NTRS)

    Maghami, Peiman G.; Kenny, Sean P.; Giesy, Daniel P.

    1997-01-01

    The software package PLATSIM provides efficient time and frequency domain analysis of large-order generic space platforms. PLATSIM can perform open-loop analysis or closed-loop analysis with linear or nonlinear control system models. PLATSIM exploits the particular form of sparsity of the plant matrices for very efficient linear and nonlinear time domain analysis, as well as frequency domain analysis. A new, original algorithm for the efficient computation of open-loop and closed-loop frequency response functions for large-order systems has been developed and is implemented within the package. Furthermore, a novel and efficient jitter analysis routine which determines jitter and stability values from time simulations in a very efficient manner has been developed and is incorporated in the PLATSIM package. In the time domain analysis, PLATSIM simulates the response of the space platform to disturbances and calculates the jitter and stability values from the response time histories. In the frequency domain analysis, PLATSIM calculates frequency response function matrices and provides the corresponding Bode plots. The PLATSIM software package is written in MATLAB script language. A graphical user interface is developed in the package to provide convenient access to its various features.

  6. Functional and cellular adaptation to weightlessness in primates

    NASA Technical Reports Server (NTRS)

    Bodine-Fowler, Sue C.; Pierotti, David J.; Talmadge, Robert J.

    1995-01-01

    Considerable data has been collected on the response of hindlimb muscles to unloading due to both spaceflight and hindlimb suspension. One generalized response to a reduction in load is muscle fiber atrophy, although not all muscles respond the same. Our understanding of how muscles respond to microgravity, however, has come primarily from the examination of hindlimb muscles in the unrestrained rate in space. The non-human primate spaceflight paradigm differs considerably from the rodent paradigm in that the monkeys are restrained, usually in a sitting position, while in space. Recently, we examined the effects of microgravity on muscles of the Rhesus monkey by taking biopsies of selected hindlimb muscles prior to and following spaceflights of 14 and 12 day durations (Cosmos 2044 and 2229). Our results revealed that the monkey's response to microgravity differs from that of the rat. The apparent differences in the atrophic response of the hindlimb muscles of the monkey and rat to spaceflight may be attributed to the following: (1) a species difference; (2) a difference in the manner in which the animals were maintained during the flight (i.e., chair restraint or 'free-floating'); and/or (3) an ability of the monkeys to counteract the effects of spaceflight with resistive exercise.

  7. Harderian Gland Tumorigenesis: Low-Dose and LET Response.

    PubMed

    Chang, Polly Y; Cucinotta, Francis A; Bjornstad, Kathleen A; Bakke, James; Rosen, Chris J; Du, Nicholas; Fairchild, David G; Cacao, Eliedonna; Blakely, Eleanor A

    2016-05-01

    Increased cancer risk remains a primary concern for travel into deep space and may preclude manned missions to Mars due to large uncertainties that currently exist in estimating cancer risk from the spectrum of radiations found in space with the very limited available human epidemiological radiation-induced cancer data. Existing data on human risk of cancer from X-ray and gamma-ray exposure must be scaled to the many types and fluences of radiations found in space using radiation quality factors and dose-rate modification factors, and assuming linearity of response since the shapes of the dose responses at low doses below 100 mSv are unknown. The goal of this work was to reduce uncertainties in the relative biological effect (RBE) and linear energy transfer (LET) relationship for space-relevant doses of charged-particle radiation-induced carcinogenesis. The historical data from the studies of Fry et al. and Alpen et al. for Harderian gland (HG) tumors in the female CB6F1 strain of mouse represent the most complete set of experimental observations, including dose dependence, available on a specific radiation-induced tumor in an experimental animal using heavy ion beams that are found in the cosmic radiation spectrum. However, these data lack complete information on low-dose responses below 0.1 Gy, and for chronic low-dose-rate exposures, and there are gaps in the LET region between 25 and 190 keV/μm. In this study, we used the historical HG tumorigenesis data as reference, and obtained HG tumor data for 260 MeV/u silicon (LET ∼70 keV/μm) and 1,000 MeV/u titanium (LET ∼100 keV/μm) to fill existing gaps of data in this LET range to improve our understanding of the dose-response curve at low doses, to test for deviations from linearity and to provide RBE estimates. Animals were also exposed to five daily fractions of 0.026 or 0.052 Gy of 1,000 MeV/u titanium ions to simulate chronic exposure, and HG tumorigenesis from this fractionated study were compared to the results from single 0.13 or 0.26 Gy acute titanium exposures. Theoretical modeling of the data show that a nontargeted effect model provides a better fit than the targeted effect model, providing important information at space-relevant doses of heavy ions.

  8. Harderian Gland Tumorigenesis: Low-Dose and LET Response

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chang, Polly Y.; Cucinotta, Francis A.; Bjornstad, Kathleen A.

    Increased cancer risk remains a primary concern for travel into deep space and may preclude manned missions to Mars due to large uncertainties that currently exist in estimating cancer risk from the spectrum of radiations found in space with the very limited available human epidemiological radiation-induced cancer data. Existing data on human risk of cancer from X-ray and gamma-ray exposure must be scaled to the many types and fluences of radiations found in space using radiation quality factors and dose-rate modification factors, and assuming linearity of response since the shapes of the dose responses at low doses below 100 mSvmore » are unknown. The goal of this work was to reduce uncertainties in the relative biological effect (RBE) and linear energy transfer (LET) relationship for space-relevant doses of charged-particle radiation-induced carcinogenesis. The historical data from the studies of Fry et al. and Alpen et al. for Harderian gland (HG) tumors in the female CB6F1 strain of mouse represent the most complete set of experimental observations, including dose dependence, available on a specific radiation-induced tumor in an experimental animal using heavy ion beams that are found in the cosmic radiation spectrum. However, these data lack complete information on low-dose responses below 0.1 Gy, and for chronic low-dose-rate exposures, and there are gaps in the LET region between 25 and 190 keV/μm. In this study, we used the historical HG tumorigenesis data as reference, and obtained HG tumor data for 260 MeV/u silicon (LET ~70 keV/μm) and 1,000 MeV/u titanium (LET ~100 keV/μm) to fill existing gaps of data in this LET range to improve our understanding of the dose-response curve at low doses, to test for deviations from linearity and to provide RBE estimates. Animals were also exposed to five daily fractions of 0.026 or 0.052 Gy of 1,000 MeV/u titanium ions to simulate chronic exposure, and HG tumorigenesis from this fractionated study were compared to the results from single 0.13 or 0.26 Gy acute titanium exposures. Theoretical modeling of the data show that a nontargeted effect model provides a better fit than the targeted effect model, providing important information at space-relevant doses of heavy ions.« less

  9. Parental Engagement: Beyond Parental Involvement in Science Education

    NASA Astrophysics Data System (ADS)

    St. Louis, Kathleen

    This study critically analyzes parents' complex stories of engagement in school and science education. The purpose is not to essentialize parental involvement, but rather to understand the processes of parental involvement and push forward the current discourse on the engagement of low-income minority and immigrant parents in schools and specifically science education. Employing critical grounded theory methods over a four-year span, this study had three areas of focus. First, voices of marginalized parents in the context of various spaces within the school system are examined. Using a qualitative approach, informal, formal, and research spaces were explored along with how minority parents express voice in these various spaces. Findings indicate parents drew on capital to express voice differently in different spaces, essentially authoring new spaces or the type of engagement in existing spaces. Second, the values and beliefs of traditionally marginalized people, the Discourse of mainstream society, and how they can inform a third, more transformative space for parental engagement in science are considered. The voices of low-income, marginalized parents around science and parental engagement (i.e., first space) are contrasted with the tenets of major national science policy documents (i.e., second space). Findings indicate a disparity between the pathways of engagement for low-income parents and policymakers who shape science education. Third, methodological questions of responsibility and assumption in qualitative research are explored. The author's complex struggle to make sense of her positionality, responsibilities, and assumptions as a researcher is chronicled. Findings focused on insider/outsider issues and implications for culturally sensitive research are discussed. Finally, the implications for policy, teaching, and research are discussed.

  10. Class Explorations in Space: From the Blackboard and History to the Outdoors and Future

    NASA Astrophysics Data System (ADS)

    Cavicchi, Elizabeth

    2011-11-01

    Our everyday activities occur so seamlessly in the space around us as to leave us unawares of space, its properties, and our use of it. What might we notice, wonder about and learn through interacting with space exploratively? My seminar class took on that question as an opening for personal and group experiences during this semester. In the process, they observe space locally and in the sky, read historical works of science involving space, and invent and construct forms in space. All these actions arise responsively, as we respond to: physical materials and space; historical resources; our seminar participants, and future learners. Checks, revisions and further developments -- on our findings, geometrical constructions, shared or personal inferences---come about observationally and collaboratively. I teach this seminar as an expression of the research pedagogy of critical exploration, developed by Eleanor Duckworth from the work of Jean Piaget, B"arbel Inhelder and the Elementary Science Study. This practice applies the quest for understanding of a researcher to spontaneous interactions evolving within a classroom. The teacher supports students in satisfying and developing their curiosities, which often results in exploring the subject matter by routes that are novel to both teacher and student. As my students ``mess about'' with geometry, string and chalk at the blackboard, in their notebooks, and in response to propositions in Euclid's Elements, they continually imagine further novel venues for using geometry to explore space. Where might their explorations go in the future? I invite you to hear from them directly!

  11. Fixed versus mixed RSA: Explaining visual representations by fixed and mixed feature sets from shallow and deep computational models.

    PubMed

    Khaligh-Razavi, Seyed-Mahdi; Henriksson, Linda; Kay, Kendrick; Kriegeskorte, Nikolaus

    2017-02-01

    Studies of the primate visual system have begun to test a wide range of complex computational object-vision models. Realistic models have many parameters, which in practice cannot be fitted using the limited amounts of brain-activity data typically available. Task performance optimization (e.g. using backpropagation to train neural networks) provides major constraints for fitting parameters and discovering nonlinear representational features appropriate for the task (e.g. object classification). Model representations can be compared to brain representations in terms of the representational dissimilarities they predict for an image set. This method, called representational similarity analysis (RSA), enables us to test the representational feature space as is (fixed RSA) or to fit a linear transformation that mixes the nonlinear model features so as to best explain a cortical area's representational space (mixed RSA). Like voxel/population-receptive-field modelling, mixed RSA uses a training set (different stimuli) to fit one weight per model feature and response channel (voxels here), so as to best predict the response profile across images for each response channel. We analysed response patterns elicited by natural images, which were measured with functional magnetic resonance imaging (fMRI). We found that early visual areas were best accounted for by shallow models, such as a Gabor wavelet pyramid (GWP). The GWP model performed similarly with and without mixing, suggesting that the original features already approximated the representational space, obviating the need for mixing. However, a higher ventral-stream visual representation (lateral occipital region) was best explained by the higher layers of a deep convolutional network and mixing of its feature set was essential for this model to explain the representation. We suspect that mixing was essential because the convolutional network had been trained to discriminate a set of 1000 categories, whose frequencies in the training set did not match their frequencies in natural experience or their behavioural importance. The latter factors might determine the representational prominence of semantic dimensions in higher-level ventral-stream areas. Our results demonstrate the benefits of testing both the specific representational hypothesis expressed by a model's original feature space and the hypothesis space generated by linear transformations of that feature space.

  12. Review of the results from the International C. elegans first experiment (ICE-FIRST)

    PubMed Central

    Adenle, A.A.; Johnsen, B.; Szewczyk, N.J.

    2009-01-01

    In an effort to speed the rate of discovery in space biology and medicine NASA introduced the now defunct model specimen program. Four nations applied this approach with C. elegans in the ICE-FIRST experiment. Here we review the standardized culturing as well as the investigation of muscle adaptation, space biology radiation, and gene expression in response to spaceflight. Muscle studies demonstrated that decreased expression of myogenic transcription factors underlie the decreased expression of myosin seen in flight, a response that would appear to be evolutionarily conserved. Radiation studies demonstrated that radiation damaged cells should be able to be removed via apoptosis in flight, and that C. elegans can be employed as a biological accumulating dosimeter. Lastly, ICE-FIRST gave us our first glimpse at the genomic response to spaceflight, suggesting that altered Insulin and/or TGF-beta signaling in-flight may underlie many of the biological changes seen in response to spaceflight. The fact that the results obtained with C. elegans appear to have strong similarities in human beings suggests that not only will C. elegans prove an invaluable model for understanding the fundamental biological changes seen during spaceflight but that it may also be invaluable for understanding those changes associated with human health concerns in space. PMID:20161164

  13. Selective interference of grasp and space representations with number magnitude and serial order processing.

    PubMed

    van Dijck, Jean-Philippe; Fias, Wim; Andres, Michael

    2015-10-01

    It has been proposed that the metrics of space, time and other magnitudes relevant for action are coupled through a generalized magnitude system that also contribute to number representation. Several studies capitalized on stimulus-response compatibility effects to show that numbers map onto left-right representations and grasp representations as a function of their magnitude. However, the tasks typically used do not allow disentangling magnitude from serial order processing. Here, we devised a working memory (WM) task where participants had to remember random sequences of numbers and perform a precision/whole-hand grip (Experiment 1) or a uni-manual left/right button press (Experiment 2) in response to numbers presented during the retention interval. This task does allow differentiating the interference of number magnitude and serial order with each set of responses. Experiment 1 showed that precision grips were initiated faster than whole-hand grips in response to small numbers, irrespective of their serial position in WM. In contrast, Experiment 2 revealed an advantage of right over left button presses as serial position increased, without any influence of number magnitude. These findings demonstrate that grasping and left-right movements overlap with distinct dimensions of number processing. These findings are discussed in the light of different theories explaining the interactions between numbers, space and action.

  14. Cytokines and macrophage function in humans - role of stress

    NASA Technical Reports Server (NTRS)

    Sonnenfeld, Gerald (Principal Investigator)

    1996-01-01

    We have begun this study to commence the determination of the role of mild chronic stress in the effects of space flight on macrophage/monocyte function, a component of the immune response. Medical students undergoing regular periods of stress and relaxation have been shown to be an excellent model for determining the effects of stress on immune responses. We have begun using this model using the macrophage/monocyte as model leukocyte. The monocyte/macrophage plays a central role in immunoregulation. The studies to be included in this three year project are the effects of stress on: (1) interactions of monocytes with microbes, (2) monocyte production of cytokines, (3) monocyte phagocytosis and activity, and (4) monocyte expression of cell surface antigens important in immune responses. Stress hormone levels will also be carried out to determine if there is a correlation between stress effects on immune responses and hormonal levels. Psychological testing to insure subjects are actually stressed or relaxed at the time of testing will also be carried out. The results obtained from the proposed studies should be comparable with space flight studies with whole animals and isolated cell cultures. When complete this study should allow the commencement of the establishment of the role of stress as one compartment of the induction of immune alterations by space flight.

  15. Space Station

    NASA Image and Video Library

    1991-01-01

    In 1982, the Space Station Task Force was formed, signaling the initiation of the Space Station Freedom Program, and eventually resulting in the Marshall Space Flight Center's responsibilities for Space Station Work Package 1.

  16. Comparing the effects of two in-flight aerobic exercise protocols on standing heart rates and VO(2peak) before and after space flight

    NASA Technical Reports Server (NTRS)

    Siconolfi, S. F.; Charles, J. B.; Moore, A. D. Jr; Barrows, L. H.

    1994-01-01

    The effects of regular aerobic exercise on orthostatic tolerance have been the subject of a long-standing controversy that will influence the use of exercise during space flight. To examine these effects, astronauts performed continuous (CE) aerobic exercise (n = 8), interval (IE) aerobic exercise (n = 4), or no (NE) exercise (n = 5) during flights of 7 to 11 days. Heart rate (HR) responses to an orthostatic challenge (stand test) were measured 10 days before flight and on landing day. VO(2peak) (graded treadmill exercise) was measured 7 to 21 days before and 2 days after flight. No significant differences across the groups were observed in standing HRs before or after flight. However, the within-group mean HRs significantly increased in the NE (71-89 beats/min) and CE (60-85 beats/min) groups after space flight. The HRs for the IE group did not significantly increase (75-86 beats/min) after space flight. VO(2peak) decreased (P < .05) in the NE (-9.5%) group, but did not change in the CE (-2.4%) and IE (1%) groups. The relationship (r = 0.237) between the delta HR and delta VO(2peak) was not significant. These preliminary results indicate that: (1) continuous exercise does not affect the orthostatic HR response after space flight; (2) interval exercise may minimize an increase in the postflight orthostatic HR; and (3) both exercise protocols can maintain VO(2peak).

  17. Alternative Fuels Data Center

    Science.gov Websites

    equipped with EVSE is responsible for the cost of the installation, maintenance, repair, removal, or restrict the installation or use of EVSE in a homeowner's designated parking space. These entities may put reasonable restrictions on EVSE, but the policies may not significantly increase the cost of the EVSE or

  18. Rodent Studies of Cardiovascular Deconditioning

    NASA Technical Reports Server (NTRS)

    Shoukas, Artin A.

    1999-01-01

    Changes in blood pressure can occur for two reasons: 1) A decrease in cardiac output resulting from the altered contractility of the heart or through changes in venous filling pressure via the Frank Starling mechanism or; 2) A change in systemic vascular resistance. The observed changes in cardiac output and blood pressure after long term space flight cannot be entirely explained through changes in contractility or heart rate alone. Therefore, alterations in filling pressure mediated through changes in systemic venous capacitance and arterial resistance function may be important determinants of cardiac output and blood pressure after long term space flight. Our laboratory and previous studies have shown the importance of veno-constriction mediated by the carotid sinus baroreceptor reflex system on overall circulatory homeostasis and in the regulation of cardiac output. Our proposed experiments test the overall hypothesis that alterations in venous capacitance function and arterial resistance by the carotid sinus baroreceptor reflex system are an important determinant of the cardiac output and blood pressure response seen in astronauts after returning to earth from long term exposure to microgravity. This hypothesis is important to our overall understanding of circulatory adjustments made during long term space flight. It also provides a framework for investigating counter measures to reduce the incidence of orthostatic hypotension caused by an attenuation of cardiac output. We continue to use hind limb unweighted (HLU) rat model to simulate the patho physiological effects as they relate to cardiovascular deconditioning in microgravity. We have used this model to address the hypothesis that microgravity induced cardiovascular deconditioning results in impaired vascular responses and that these impaired vascular responses result from abnormal alpha-1 AR signaling. The impaired vascular reactivity results in attenuated blood pressure and cardiac output responses to an orthostatic challenge. We have used in vitro vascular reactivity assays to explore abnormalities in vascular responses in vessels from HLU animals and, cardiac output (CO), blood pressure (BP) and heart rate (HR) measurements to characterize changes in hemodynamics following HLU.

  19. Environmentally-induced discharge transient coupling to spacecraft

    NASA Technical Reports Server (NTRS)

    Viswanathan, R.; Barbay, G.; Stevens, N. J.

    1985-01-01

    The Hughes SCREENS (Space Craft Response to Environments of Space) technique was applied to generic spin and 3-axis stabilized spacecraft models. It involved the NASCAP modeling for surface charging and lumped element modeling for transients coupling into a spacecraft. A differential voltage between antenna and spun shelf of approx. 400 V and current of 12 A resulted from discharge at antenna for the spinner and approx. 3 kv and 0.3 A from a discharge at solar panels for the 3-axis stabilized Spacecraft. A typical interface circuit response was analyzed to show that the transients would couple into the Spacecraft System through ground points, which are most vulnerable. A compilation and review was performed on 15 years of available data from electron and ion current collection phenomena. Empirical models were developed to match data and compared with flight data of Pix-1 and Pix-2 mission. It was found that large space power systems would float negative and discharge if operated at or above 300 V. Several recommendations are given to improve the models and to apply them to large space systems.

  20. Development and application of contamination technology for MSFC managed space systems

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The second annual report on the development and application of contamination technology for MSFC managed space systems covering the period from 10 Dec. 1992 to 10 Dec. 1993 is presented. During this time period, studies were concluded which proved that in-process corrosion protection is not required during Redesigned Solid Rocket Motor (RSRM) case processing. Also completed were a series of tests evaluating the effects of environmental exposure and contamination on 2219-T87 aluminum (Space Shuttle External Tank) OSEE response and bonding properties. Correlations were developed between OSEE response, contamination type/level, and primer adhesion. The results showed that the wet tape and water break free tests currently employed during ET processing may not detect bond affecting levels of some potential contaminants; however, the contaminants were detected with OSEE analysis. Finally, exposure/contamination studies were initiated with HP9-4-30 steel. HP9-4-30 was selected for evaluation because it represents a class of metals commom to MSFC managed space flight systems which are less prone to oxidation than D6AC steel or aluminum.

  1. Otolithic and extraocular muscle proprioceptive influences on the spatial organization of the vestibulo- and cervico-ocular quick phases.

    PubMed

    Pettorossi, V E; Manni, E; Errico, P; Ferraresi, A; Bortolami, R

    1997-03-01

    The cervico-ocular reflex (COR) was studied alone or in combination with the vestibulo-ocular reflex (VOR) in the rabbit. Step stimulations of the body with respect to the fixed head induced small slow compensatory responses followed by large compensatory quick phases (QP). These responses remained aligned with the horizon at different head pitch angles. The QP reorientation in space was due to the gravity influence on the otolithic receptors. The vestibular induced QPs exhibit a similar pattern. Because of this reorientation, the reduction of the amplitude of the vestibular induced QPs, due to the addition of the COR, was maintained even at different static head positions. The electrolytic lesion of the ophthalmic branch of the trigeminal nerve deeply affected the space orientation of the COR. In particular, the cervically induced compensatory QPs of the eye ipsilateral to the lesion showed a remarkable variability of their trajectories and they lost space reorientation. These findings suggest that the coordinate system controlling the QPs is influenced by signals originating from both head position in space and eye position in the orbit.

  2. Development and application of contamination technology for MSFC managed space systems

    NASA Astrophysics Data System (ADS)

    The second annual report on the development and application of contamination technology for MSFC managed space systems covering the period from 10 Dec. 1992 to 10 Dec. 1993 is presented. During this time period, studies were concluded which proved that in-process corrosion protection is not required during Redesigned Solid Rocket Motor (RSRM) case processing. Also completed were a series of tests evaluating the effects of environmental exposure and contamination on 2219-T87 aluminum (Space Shuttle External Tank) OSEE response and bonding properties. Correlations were developed between OSEE response, contamination type/level, and primer adhesion. The results showed that the wet tape and water break free tests currently employed during ET processing may not detect bond affecting levels of some potential contaminants; however, the contaminants were detected with OSEE analysis. Finally, exposure/contamination studies were initiated with HP9-4-30 steel. HP9-4-30 was selected for evaluation because it represents a class of metals commom to MSFC managed space flight systems which are less prone to oxidation than D6AC steel or aluminum.

  3. Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight?

    PubMed Central

    Sng, Natasha J.; Zupanska, Agata K.; Krishnamurthy, Aparna; Schultz, Eric R.; Ferl, Robert J.

    2017-01-01

    Experimentation on the International Space Station has reached the stage where repeated and nuanced transcriptome studies are beginning to illuminate the structural and metabolic differences between plants grown in space compared to plants on the Earth. Genes that are important in establishing the spaceflight responses are being identified, their roles in spaceflight physiological adaptation are increasingly understood, and the fact that different genotypes adapt differently is recognized. However, the basic question of whether these spaceflight responses are actually required for survival has yet to be posed, and the fundamental notion that spaceflight responses may be non-adaptive has yet to be explored. Therefore the experiments presented here were designed to ask if portions of the plant spaceflight response can be genetically removed without causing loss of spaceflight survival and without causing increased stress responses. The CARA experiment compared the spaceflight transcriptome responses in the root tips of two Arabidopsis ecotypes, Col-0 and WS, as well as that of a PhyD mutant of Col-0. When grown with the ambient light of the ISS, phyD plants displayed a significantly reduced spaceflight transcriptome response compared to Col-0, suggesting that altering the activity of a single gene can actually improve spaceflight adaptation by reducing the transcriptome cost of physiological adaptation. The WS genotype showed an even simpler spaceflight transcriptome response in the ambient light of the ISS, more broadly indicating that the plant genotype can be manipulated to reduce the cost of spaceflight adaptation, as measured by transcriptional response. These differential genotypic responses suggest that genetic manipulation could further reduce, or perhaps eliminate the metabolic cost of spaceflight adaptation. When plants were germinated and then left in the dark on the ISS, the WS genotype actually mounted a larger transcriptome response than Col-0, suggesting that the in-space light environment affects physiological adaptation, which implies that manipulating the local habitat can also substantially impact the metabolic cost of spaceflight adaptation. PMID:28662188

  4. Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight?

    PubMed

    Paul, Anna-Lisa; Sng, Natasha J; Zupanska, Agata K; Krishnamurthy, Aparna; Schultz, Eric R; Ferl, Robert J

    2017-01-01

    Experimentation on the International Space Station has reached the stage where repeated and nuanced transcriptome studies are beginning to illuminate the structural and metabolic differences between plants grown in space compared to plants on the Earth. Genes that are important in establishing the spaceflight responses are being identified, their roles in spaceflight physiological adaptation are increasingly understood, and the fact that different genotypes adapt differently is recognized. However, the basic question of whether these spaceflight responses are actually required for survival has yet to be posed, and the fundamental notion that spaceflight responses may be non-adaptive has yet to be explored. Therefore the experiments presented here were designed to ask if portions of the plant spaceflight response can be genetically removed without causing loss of spaceflight survival and without causing increased stress responses. The CARA experiment compared the spaceflight transcriptome responses in the root tips of two Arabidopsis ecotypes, Col-0 and WS, as well as that of a PhyD mutant of Col-0. When grown with the ambient light of the ISS, phyD plants displayed a significantly reduced spaceflight transcriptome response compared to Col-0, suggesting that altering the activity of a single gene can actually improve spaceflight adaptation by reducing the transcriptome cost of physiological adaptation. The WS genotype showed an even simpler spaceflight transcriptome response in the ambient light of the ISS, more broadly indicating that the plant genotype can be manipulated to reduce the cost of spaceflight adaptation, as measured by transcriptional response. These differential genotypic responses suggest that genetic manipulation could further reduce, or perhaps eliminate the metabolic cost of spaceflight adaptation. When plants were germinated and then left in the dark on the ISS, the WS genotype actually mounted a larger transcriptome response than Col-0, suggesting that the in-space light environment affects physiological adaptation, which implies that manipulating the local habitat can also substantially impact the metabolic cost of spaceflight adaptation.

  5. Developing Tools and Techniques to Increase Communication Effectiveness

    NASA Technical Reports Server (NTRS)

    Hayes, Linda A.; Peterson, Doug

    1997-01-01

    The Public Affairs Office (PAO) of the Johnson Space Center (JSC) is responsible for communicating current JSC Space Program activities as well as goals and objectives to the American Public. As part of the 1996 Strategic Communications Plan, a review of PAO' s current communication procedures was conducted. The 1996 Summer Faculty Fellow performed research activities to support this effort by reviewing current research concerning NASA/JSC's customers' perceptions and interests, developing communications tools which enable PAO to more effectively inform JSC customers about the Space Program, and proposing a process for developing and using consistent messages throughout PAO. Note that this research does not attempt to change or influence customer perceptions or interests but, instead, incorporates current customer interests into PAO's communication process.

  6. Increased Fire and Toxic Contaminant Detection Responsibility by Use of Distributed, Aspirating Sensors

    NASA Technical Reports Server (NTRS)

    Youngblood, Wallace W.

    1990-01-01

    Viewgraphs of increased fire and toxic contaminant detection responsivity by use of distributed, aspirating sensors for space station are presented. Objectives of the concept described are (1) to enhance fire and toxic contaminant detection responsivity in habitable regions of space station; (2) to reduce system weight and complexity through centralized detector/monitor systems; (3) to increase fire signature information from selected locations in a space station module; and (4) to reduce false alarms.

  7. jsc2018m000274_Alpha-Space-Small-Business-Makes-Big-Strides_MP4

    NASA Image and Video Library

    2018-03-30

    The path to discovery and exploration is paved with determination, innovation, and most of all, big ideas. The International Space Station is home to many of those ideas and creating new ways for small businesses, entrepreneurs and researchers to test their science and technology in space every day.Formed in 2015 in response to the need for a commercial payload that would be available to private companies aboard the space station, Alpha Space is a woman- and minority-owned small business responsible for developing the Materials International Space Station Experiment Flight Facility (MISSE-FF).

  8. Estimating the effect of selected predictors on agricultural confined-space hazard perceptions of Utah farm owner/operators.

    PubMed

    Pate, M L; Dai, X

    2014-04-01

    The purpose of this study was to assess how selected variables affect the confined-space hazard perceptions of farmers in Utah. A confined space was defined as "any space found in an agricultural workplace that was not designed or intended as a regular workstation, has limited or restricted means of entry or exit, and contains potential physical and toxic hazards to workers who intentionally or unintentionally enter the space" (proposed by NCERA-197, 18 May 2011, draft copy). A total of 303 out of 327 farm owner/operators provided complete surveys that were used in the analysis. The state of Utah was grouped into five regions in this study: central, east, northeast, northwest, and southwest. Grain and dairy production comprised 48.7% of the operations responding to the survey. The general linear modeling (GLM) procedure in SAS 9.3 was used to select the models on hazard perception scores for the five studied regions. Interested predictors included response type, production type, safety planning, and injury concerns. Animal production operations had the highest average number of confined spaces (micro = 4, SD = 2.7). Regionally, the northwest region had the highest average number of confined spaces (micro = 4, SD = 2.5). The variables contributing most to confined-space hazard perceptions were injury and death concerns while working alone in confined spaces. Three factors were generated using principle factor analysis (PFA) with orthogonal varimax rotation. Results suggested that factors affect hazard perceptions differently by region. We conclude that outreach and educational efforts to change safety behaviors regarding confined-space hazards should be strategically targeted for each region based on predicting factors. The result can assist agricultural safety and health professionals in targeting agricultural producers' social networks to address human factors such as worker attitudes and/or lack of skills or knowledge that effect hazard perceptions of confined spaces in agriculture.

  9. Cardiovascular responses to hypogravic environments

    NASA Technical Reports Server (NTRS)

    Sandler, H.

    1983-01-01

    The cardiovascular deconditioning observed during and after space flight is characterized in a review of human space and simulation studies and animal simulations. The various simulation techniques (horizontal bed rest, head-down tilt, and water immersion in man, and immobilization of animals) are examined, and sample results are presented in graphs. Countermeasures such as exercise regimens, fluid replacement, drugs, venous pooling, G-suits, oscillating beds, electrostimulation of muscles, lower-body negative pressure, body-surface cooling, and hypoxia are reviewed and found to be generally ineffective or unreliable. The need for future space experimentation in both humans and animals is indicated.

  10. Morphogenetic responses of cultured totipotent cells of carrot /Daucus carota var. carota/ at zero gravity

    NASA Technical Reports Server (NTRS)

    Krikorian, A. D.; Steward, F. C.

    1978-01-01

    An experiment designed to test whether embryos capable of developing from isolated somatic carrot cells could do so under conditions of weightlessness in space was performed aboard the unmanned Soviet biosatellite Kosmos 782 under the auspices of the joint United States-Soviet Biological Satellite Mission. Space flight and weightlessness seem to have had no adverse effects on the induction of embryoids or on the development of their organs. A portion of the crop of carrot plantlets originated in space and grown to maturity were not morphologically different from controls.

  11. Nonlinearities, scale-dependence, and individualism of boreal forest trees to climate forcing

    NASA Astrophysics Data System (ADS)

    Wolken, J. M.; Mann, D. H.; Grant, T. A., III; Lloyd, A. H.; Hollingsworth, T. N.

    2013-12-01

    Our understanding of the climate-growth relationships of trees are complicated by the nonlinearity and variability of these responses through space and time. Furthermore, trees growing at the same site may exhibit opposing growth responses to climate, a phenomenon termed growth divergence. To date the majority of dendrochronological studies in Interior Alaska have involved white spruce growing at treeline, even though black spruce is the most abundant tree species. Although changing climate-growth relationships have been observed in black spruce, there is little known about the multivariate responses of individual trees to temperature and precipitation and whether or not black spruce exhibits growth divergences similar to those documented for white spruce. To evaluate the occurrence of growth divergences in black spruce, we collected cores from trees growing on a steep, north-facing toposequence having a gradient in environmental parameters. Our overall goal was to assess how the climate-growth relationships of black spruce change over space and time. Specifically, we evaluated how topography influences the climate-growth relationships of black spruce and if the growth responses to climate are homogeneous. At the site-level most trees responded negatively to temperature and positively to precipitation, while at the tree-level black spruce exhibited heterogenous growth responses to climate that varied in both space (i.e., between sites) and time (i.e., seasonally and annually). There was a dominant response-type at each site, but there was also considerable variability in the proportion of trees exhibiting each response-type combination. Even in a climatically extreme setting like Alaska's boreal forest, tree responses to climate variability are spatially and temporally complex, as well as highly nonlinear.

  12. Creating a Team Archive During Fast-Paced Anomaly Response Activities in Space Missions

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Hicks, LaDessa; Overland, David; Thronesbery, Carroll; Christofferesen, Klaus; Chow, Renee

    2002-01-01

    This paper describes a Web-based system to support the temporary Anomaly Response Team formed from distributed subteams in Space Shuttle and International Space Station missions. The system was designed for easy and flexible creation of small collections of files and links associated with work on a particular anomaly. The system supports privacy and levels of formality for the subteams. First we describe the supported groups and an anomaly response scenario. Then we describe the support system prototype, the Anomaly Response Tracking and Integration System (ARTIS). Finally, we describe our evaluation approach and the results of the evaluation.

  13. Hazard Analysis for the Mark III Space Suit Assembly (SSA) Used in One-g Operations

    NASA Technical Reports Server (NTRS)

    Mitchell, Kate; Ross, Amy; Blanco, Raul; Wood, Art

    2012-01-01

    This Hazard Analysis document encompasses the Mark III Space Suit Assembly (SSA) and associated ancillary equipment. It has been prepared using JSC17773, "Preparing Hazard Analyses for JSC Ground Operation", as a guide. The purpose of this document is to present the potential hazards involved in ground (23 % maximum O2, One-g) operations of the Mark III and associated ancillary support equipment system. The hazards listed in this document are specific to suit operations only; each supporting facility (Bldg. 9, etc.) is responsible for test specific Hazard Analyses. A "hazard" is defined as any condition that has the potential for harming personnel or equipment. This analysis was performed to document the safety aspects associated with manned use of the Mark III for pressurized and unpressurized ambient, ground-based, One-g human testing. The hazards identified herein represent generic hazards inherent to all standard JSC test venues for nominal ground test configurations. Non-standard test venues or test specific configurations may warrant consideration of additional hazards analysis prior to test. The cognizant suit engineer is responsible for the safety of the astronaut/test subject, space suit, and suit support personnel. The test requester, for the test supported by the suit test engineer and suited subject, is responsible for overall safety and any necessary Test Readiness Reviews (TRR).

  14. Biological response of plantation cottonwood to spacing, pruning and thinning

    Treesearch

    R. J. Gascon; R. M. Krinard

    1976-01-01

    A literature review and a sampling of data obtained from cottonwood growers of the biological response of plantation-grown cottonwood trees to initial spacings in the Midsouth have indicated the following trends: as spacing increased, dbh increased, height of dominants not practically affected, total cubic volume decreased, basal area decreased, natural pruning...

  15. 14 CFR § 1251.106 - Designation of responsible employee and adoption of grievance procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Designation of responsible employee and adoption of grievance procedures. § 1251.106 Section § 1251.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON BASIS OF HANDICAP General Provisions § 1251.106...

  16. FASTSAT-HSV01 synergistic observations of the magnetospheric response during active periods: MINI-ME, PISA and TTI

    NASA Astrophysics Data System (ADS)

    Casas, Joseph; Collier, Michael; Rowland, Douglas; Sigwarth, John; Boudreaux, Mark

    Understanding the complex processes within the inner magnetosphere of Earth particularly during storm periods requires coordinated observations of the particle and field environment using both in-situ and remote sensing techniques. In fact in order to gain a better understand-ing of our Heliophysics and potentially improve our space weather forecasting capabilities, new observation mission approaches and new instrument technologies which can provide both cost effective and robust regular observations of magnetospheric activity and other space weather related phenomenon are necessary. As part of the effort to demonstrate new instrument tech-niques and achieve necessary coordinated observation missions, NASA's Fast Affordable Sci-ence and Technology Satellite Huntsville 01 mission (FASTSAT-HSV01) scheduled for launch in 2010 will afford a highly synergistic solution which satisfies payload mission opportunities and launch requirements as well as contributing in the near term to our improved understanding of Heliophysics. NASA's FASTSAT-HSV01 spacecraft on the DoD Space Test Program-S26 (STP-S26) Mission is a multi-payload mission executed by the DoD Space Test Program (STP) at the Space Development and Test Wing (SDTW), Kirtland AFB, NM. and is an example of a responsive and economical breakthrough in providing new possibilities for small space technology-driven and research missions. FASTSAT-HSV is a unique spacecraft platform that can carry multiple small instruments or experiments to low-Earth orbit on a wide range of expendable launch vehicles for a fraction of the cost traditionally required for such missions. The FASTSAT-HSV01 mission allows NASA to mature and transition a technical capability to industry while increasing low-cost access to space for small science and technology (ST) payloads. The FASTSAT-HSV01 payload includes three NASA Goddard Space Flight Center (GSFC) new technology built instruments that will study the terrestrial space environment and potentially contribute to space weather research in a synergistic manner. MINI-ME, a neutral atom imager, will observe the neutral atom inputs to ionospheric heating which can be important during high levels of magnetospheric activity. PISA, a plasma impedance spec-trometer, will measure simultaneously the local electron densities and temperatures as well as measure small scale density structure (500 m spatial scale) during these active periods. TTI, a thermospheric imager, will remotely determine the thermospheric temperature response to this magnetospheric activity. Together, these observations will contribute significantly to a comprehensive understanding of the flow of energy through and the response of the storm-time terrestrial magnetosphere.

  17. FASTSAT-HSV01 Synergistic Observations of the Magnetospheric Response During Active Periods: MINI-ME, PISA and TTI

    NASA Technical Reports Server (NTRS)

    Casas, Joseph C.; Collier, Michael R.; Rowland, Douglas E.; Sigwarth, John B.; Boudreaux, Mark E.

    2010-01-01

    Understanding the complex processes within the inner magnetosphere of Earth particularly during storm periods requires coordinated observations of the particle and field environment using both in-situ and remote sensing techniques. In fact in order to gain a better understanding of our Heliophysics and potentially improve our space weather forecasting capabilities, new observation mission approaches and new instrument technologies which can provide both cost effective and robust regular observations of magnetospheric activity and other space weather related phenomenon are necessary. As part of the effort to demonstrate new instrument techniques and achieve necessary coordinated observation missions, NASA's Fast Affordable Science and Technology Satellite Huntsville 01 mission (FASTSAT-HSVOI) scheduled for launch in 2010 will afford a highly synergistic solution which satisfies payload mission opportunities and launch requirements as well as contributing iri the near term to our improved understanding of Heliophysics. NASA's FASTSAT-HSV01 spacecraft on the DoD Space Test Program-S26 (STP-S26) Mission is a multi-payload mission executed by the DoD Space Test Program (STP) at the Space Development and Test Wing (SDTW), Kirtland AFB, NM. and is an example of a responsive and economical breakthrough in providing new possibilities for small space technology-driven and research missions. FASTSAT-HSV is a unique spacecraft platform that can carry multiple small instruments or experiments to low-Earth orbit on a wide range of expendable launch vehicles for a fraction of the cost traditionally required for such missions. The FASTSAT-HSV01 mission allows NASA to mature and transition a technical capability to industry while increasing low-cost access to space for small science and technology (ST) payloads. The FASTSAT-HSV01 payload includes three NASA Goddard Space Flight Center (GSFC) new technology built instruments that will study the terrestrial space environment and potentially contribute to space weather research in a synergistic manner. MINI-ME, a neutral atom imager, will observe the neutral atom inputs to ionospheric heating which can be important during high levels of magnetospheric activity. PISA, a plasma impedance spectrometer, will measure simultaneously the local electron densities and temperatures as well as measure small scale density structure (500 m spatial scale) during these active periods. TTI, a thermospheric imager, will remotely determine the thermospheric temperature response to this magnetospheric activity. Together, these observations will contribute significantly to a comprehensive understanding of the flow of energy through and the response of the storm-time terrestrial magnetosphere.

  18. Collaborative Commercial Space Situational Awareness

    NASA Astrophysics Data System (ADS)

    Kelso, T. S.; Hendrix, D.; Sibert, D.; Hall, R. A.; Therien, W.

    2013-09-01

    There is an increasing recognition by commercial and civil space operators of the need for space situational awareness (SSA) data to support ongoing conjunction analysis, maneuver planning, and radio frequency interference mitigation as part of daily operations. While some SSA data is available from the Joint Space Operations Center via the Space Track web site, access to raw observations and photometric data is limited due to national security considerations. These data, however, are of significant value in calibrating intra- and inter-operator orbit determination results, determining inter-system biases, and assessing operating profiles in the geostationary orbit. This paper details an ongoing collaborative effort to collect and process optical observations and photometric data using a network of low-cost telescope installations and shows how these data are being used to support ongoing operations in the Space Data Center. This presentation will demonstrate how by leveraging advance photometric processing algorithms developed for Missile Defense Agency and the Ballistic Missile Defense (BMD) mission ExoAnalytic and AGI have been able to provide actionable SSA for satellite operators from small telescopes in less than optimal viewing conditions. Space has become an increasingly cluttered environment requiring satellite operators to remain forever vigilant in order to prevent collisions to preserve their assets and prevent further cluttering the space environment. The Joint Space Operations Center (JSpOC), which tracks all objects in earth orbit, reports possible upcoming conjunctions to operators by providing Conjunction Summary Messages (CSMs). However due to large positional uncertainties in the forward predicted position of space objects at the time closest approach the volume of CSMs is excessive to the point that maneuvers in response to CSMs without additional screening is cost prohibitive. CSSI and the Space Data Association have been able to screen most CSMs by using more accurate operator ephemeris. By screening with operator ephemeris alone they have been able to demonstrate that safety limits will not be exceeded in a good number of these encounters and that extra delta-V need to not be expended in a Collision Avoidance (COLA) maneuver. However there remains a decent portion of alerts that may warrant action especially when the secondary object is an uncontrolled space object such as a dead satellite or rocket body. By dynamically tasking the ESpOC observatories to provide real-time tracking and photometric characterization of the secondary objects in response to these CSMs satellite operators benefit from an additional method of conjunction screening. The refined tracks and conjunction assessments obtained by ESpOC screening allows operators to safely reduce the number of COLAs performed in response to safe close approaches and provide optimized COLA maneuver planning in response to validated threats.

  19. Mediating Transnational Spaces: International Students and Intercultural Responsibility

    ERIC Educational Resources Information Center

    Tran, Ly Thi; Vu, Thao Thi Phuong

    2017-01-01

    Despite the significant body of literature on international students' intercultural development, the core issue of how they see their own responsibility in transnational intercultural spaces is largely neglected. This paper addresses this paucity by examining the intercultural responsibility perceived by international students. It is based on a…

  20. 14 CFR 223.5 - Responsibility of agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Responsibility of agencies. 223.5 Section 223.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... Weather Service, and the Postal Service shall be responsible for the following: (a) The issuance of any...

  1. 14 CFR 223.5 - Responsibility of agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Responsibility of agencies. 223.5 Section 223.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... Weather Service, and the Postal Service shall be responsible for the following: (a) The issuance of any...

  2. 14 CFR 223.5 - Responsibility of agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Responsibility of agencies. 223.5 Section 223.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... Weather Service, and the Postal Service shall be responsible for the following: (a) The issuance of any...

  3. 14 CFR 223.5 - Responsibility of agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Responsibility of agencies. 223.5 Section 223.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... Weather Service, and the Postal Service shall be responsible for the following: (a) The issuance of any...

  4. 14 CFR 223.5 - Responsibility of agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Responsibility of agencies. 223.5 Section 223.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... Weather Service, and the Postal Service shall be responsible for the following: (a) The issuance of any...

  5. Small Satellite Constellations: The Future for Operational Earth Observation

    NASA Technical Reports Server (NTRS)

    Stephens, J. Paul

    2007-01-01

    Nanosat, microsat and minisat are low-cost, rapid-response small-satellites built from advanced terrestrial technology. SSTL delivers the benefits of affordable access to space through low-cost, rapid response, small satellites designed and built with state-of-the-art COTS technologies by: a) reducing the cost of entry into space; b) Achieving more missions within fixed budgets; c) making constellations and formation flying financially viable; d) responding rapidly from initial concept to orbital operation; and e) bringing the latest industrial COTS component advances to space. Growth has been stimulated in constellations for high temporal revisit&persistent monitoring and military responsive space assets.

  6. Optimized shielding for space radiation protection

    NASA Technical Reports Server (NTRS)

    Wilson, J. W.; Cucinotta, F. A.; Kim, M. H.; Schimmerling, W.

    2001-01-01

    Future deep space mission and International Space Station exposures will be dominated by the high-charge and -energy (HZE) ions of the Galactic Cosmic Rays (GCR). A few mammalian systems have been extensively tested over a broad range of ion types and energies. For example, C3H10T1/2 cells, V79 cells, and Harderian gland tumors have been described by various track-structure dependent response models. The attenuation of GCR induced biological effects depends strongly on the biological endpoint, response model used, and material composition. Optimization of space shielding is then driven by the nature of the response model and the transmission characteristics of the given material.

  7. Optimized Shielding for Space Radiation Protection

    NASA Technical Reports Server (NTRS)

    Wilson, J. W.; Cucinotta, F. A.; Kim, M.-H. Y.; Schimmerling, W.

    2000-01-01

    Abstract. Future deep space mission and International Space Station exposures will be dominated by the high-charge and -energy (HZE) ions of the Galactic Cosmic Rays (GCR). A few mammalian systems have been extensively tested over a broad range of ion types and energies. For example, C3H10T1/2 cells, V79 cells, and Harderian gland tumors have been described by various track-structure dependent response models. The attenuation of GCR induced biological effects depends strongly on the biological endpoint, response model used, and material composition. Optimization of space shielding is then driven by the nature of the response model and the transmission characteristics of the given material.

  8. International Space Station medical standards and certification for space flight participants.

    PubMed

    Bogomolov, Valery V; Castrucci, Filippo; Comtois, Jean-Marc; Damann, Volker; Davis, Jeffrey R; Duncan, J Michael; Johnston, Smith L; Gray, Gary W; Grigoriev, Anatoly I; Koike, Yu; Kuklinski, Paul; Matveyev, Vladimir P; Morgun, Valery V; Pochuev, Vladimir I; Sargsyan, Ashot E; Shimada, Kazuhito; Straube, Ulrich; Tachibana, Shoichi; Voronkov, Yuri V; Williams, Richard S

    2007-12-01

    The medical community of the International Space Station (ISS) has developed joint medical standards and evaluation requirements for Space Flight Participants ("space tourists") which are used by the ISS medical certification board to determine medical eligibility of individuals other than professional astronauts (cosmonauts) for short-duration space flight to the ISS. These individuals are generally fare-paying passengers without operational responsibilities. By means of this publication, the medical standards and evaluation requirements for the ISS Space Flight Participants are offered to the aerospace medicine and commercial spaceflight communities for reference purposes. It is emphasized that the criteria applied to the ISS spaceflight participant candidates are substantially less stringent than those for professional astronauts and/or crewmembers of visiting and long-duration missions to the ISS. These medical standards are released by the government space agencies to facilitate the development of robust medical screening and medical risk assessment approaches in the context of the evolving commercial human spaceflight industry.

  9. KSC-03PD-3141

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. Center Director Jim Kennedy presents a NASA Public Service Award to Douglas Britt of the Dynamac Corp. at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Britt received the award for his many years of exceptional service to NASA in managing the Life Sciences contracts at the Kennedy Space Center and his contributions to conceptualization and collaborations that helped make the Space Life Sciences Lab possible. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  10. KSC-03PD-3140

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. Center Director Jim Kennedy presents a NASA Public Service Award to Douglas Britt of the Dynamac Corp. at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Britt received the award for his many years of exceptional service to NASA in managing the Life Sciences contracts at the Kennedy Space Center and his contributions to conceptualization and collaborations that helped make the Space Life Sciences Lab possible. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  11. Using Knowledge Space Theory To Assess Student Understanding of Stoichiometry

    NASA Astrophysics Data System (ADS)

    Arasasingham, Ramesh D.; Taagepera, Mare; Potter, Frank; Lonjers, Stacy

    2004-10-01

    Using the concept of stoichiometry we examined the ability of beginning college chemistry students to make connections among the molecular, symbolic, and graphical representations of chemical phenomena, as well as to conceptualize, visualize, and solve numerical problems. Students took a test designed to follow conceptual development; we then analyzed student responses and the connectivities of their responses, or the cognitive organization of the material or thinking patterns, applying knowledge space theory (KST). The results reveal that the students' logical frameworks of conceptual understanding were very weak and lacked an integrated understanding of some of the fundamental aspects of chemical reactivity. Analysis of response states indicates that the overall thinking patterns began with symbolic representations, moved to numerical problem solving, and then lastly to visualization: the acquisition of visualization skills comes later in the knowledge structure. The results strongly suggest the need for teaching approaches that help students integrate their knowledge by emphasizing the relationships between the different representations and presenting them concurrently during instruction. Also, the results indicate that KST is a useful tool for revealing various aspects of students' cognitive structure in chemistry and can be used as an assessment tool or as a pedagogical tool to address a number of student-learning issues.

  12. Intralaminar stimulation of the inferior colliculus facilitates frequency-specific activation in the auditory cortex

    NASA Astrophysics Data System (ADS)

    Allitt, B. J.; Benjaminsen, C.; Morgan, S. J.; Paolini, A. G.

    2013-08-01

    Objective. Auditory midbrain implants (AMI) provide inadequate frequency discrimination for open set speech perception. AMIs that can take advantage of the tonotopic laminar of the midbrain may be able to better deliver frequency specific perception and lead to enhanced performance. Stimulation strategies that best elicit frequency specific activity need to be identified. This research examined the characteristic frequency (CF) relationship between regions of the auditory cortex (AC), in response to stimulated regions of the inferior colliculus (IC), comparing monopolar, and intralaminar bipolar electrical stimulation. Approach. Electrical stimulation using multi-channel micro-electrode arrays in the IC was used to elicit AC responses in anaesthetized male hooded Wistar rats. The rate of activity in AC regions with CFs within 3 kHz (CF-aligned) and unaligned CFs was used to assess the frequency specificity of responses. Main results. Both monopolar and bipolar IC stimulation led to CF-aligned neural activity in the AC. Altering the distance between the stimulation and reference electrodes in the IC led to changes in both threshold and dynamic range, with bipolar stimulation with 400 µm spacing evoking the lowest AC threshold and widest dynamic range. At saturation, bipolar stimulation elicited a significantly higher mean spike count in the AC at CF-aligned areas than at CF-unaligned areas when electrode spacing was 400 µm or less. Bipolar stimulation using electrode spacing of 400 µm or less also elicited a higher rate of elicited activity in the AC in both CF-aligned and CF-unaligned regions than monopolar stimulation. When electrodes were spaced 600 µm apart no benefit over monopolar stimulation was observed. Furthermore, monopolar stimulation of the external cortex of the IC resulted in more localized frequency responses than bipolar stimulation when stimulation and reference sites were 200 µm apart. Significance. These findings have implications for the future development of AMI, as a bipolar stimulation strategy may improve the ability of implant users to discriminate between frequencies.

  13. Population Coding of Visual Space: Modeling

    PubMed Central

    Lehky, Sidney R.; Sereno, Anne B.

    2011-01-01

    We examine how the representation of space is affected by receptive field (RF) characteristics of the encoding population. Spatial responses were defined by overlapping Gaussian RFs. These responses were analyzed using multidimensional scaling to extract the representation of global space implicit in population activity. Spatial representations were based purely on firing rates, which were not labeled with RF characteristics (tuning curve peak location, for example), differentiating this approach from many other population coding models. Because responses were unlabeled, this model represents space using intrinsic coding, extracting relative positions amongst stimuli, rather than extrinsic coding where known RF characteristics provide a reference frame for extracting absolute positions. Two parameters were particularly important: RF diameter and RF dispersion, where dispersion indicates how broadly RF centers are spread out from the fovea. For large RFs, the model was able to form metrically accurate representations of physical space on low-dimensional manifolds embedded within the high-dimensional neural population response space, suggesting that in some cases the neural representation of space may be dimensionally isomorphic with 3D physical space. Smaller RF sizes degraded and distorted the spatial representation, with the smallest RF sizes (present in early visual areas) being unable to recover even a topologically consistent rendition of space on low-dimensional manifolds. Finally, although positional invariance of stimulus responses has long been associated with large RFs in object recognition models, we found RF dispersion rather than RF diameter to be the critical parameter. In fact, at a population level, the modeling suggests that higher ventral stream areas with highly restricted RF dispersion would be unable to achieve positionally-invariant representations beyond this narrow region around fixation. PMID:21344012

  14. Trade Spaces in Crewed Spacecraft Atmosphere Revitalization System Development

    NASA Technical Reports Server (NTRS)

    Perry, Jay L.; Bagdigian, Robert M.; Carrasquillo, Robyn L.

    2010-01-01

    Developing the technological response to realizing an efficient atmosphere revitalization system for future crewed spacecraft and space habitats requires identifying and describing functional trade spaces. Mission concepts and requirements dictate the necessary functions; however, the combination and sequence of those functions possess significant flexibility. Us-ing a closed loop environmental control and life support (ECLS) system architecture as a starting basis, a functional unit operations approach is developed to identify trade spaces. Generalized technological responses to each trade space are discussed. Key performance parameters that apply to functional areas are described.

  15. Analysis and testing of a space crane articulating joint testbed

    NASA Technical Reports Server (NTRS)

    Sutter, Thomas R.; Wu, K. Chauncey

    1992-01-01

    The topics are presented in viewgraph form and include: space crane concept with mobile base; mechanical versus structural articulating joint; articulating joint test bed and reference truss; static and dynamic characterization completed for space crane reference truss configuration; improved linear actuators reduce articulating joint test bed backlash; 1-DOF space crane slew maneuver; boom 2 tip transient response finite element dynamic model; boom 2 tip transient response shear-corrected component modes torque driver profile; peak root member force vs. slew time torque driver profile; and open loop control of space crane motion.

  16. Encyclopedia: Satellites and Sounding Rockets, August 1959 - December 1969

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Major space missions utilizing satellites or sounding rockets managed by the NASA Goddard Space Flight Center between August 1959 and December 1969 were documented. The information was presented in the following form: (1) description of each satellite project where Goddard was responsible for the spacecraft or the successful launch or both, with data such as launch characteristics, objectives, etc.; (2) description of each Goddard sounding rocket project, with the following data: sounding rocket type, vehicle number, experimental affiliation, and type of experiment; (3) brief description of current sounding rockets and launch vehicles; (4) table of tracking and data acquisition stations. Summary tables are also provided.

  17. Cost and risk assessment for spacecraft operation decisions caused by the space debris environment

    NASA Astrophysics Data System (ADS)

    Schaub, Hanspeter; Jasper, Lee E. Z.; Anderson, Paul V.; McKnight, Darren S.

    2015-08-01

    Space debris is a topic of concern among many in the space community. Most forecasting analyses look centuries into the future to attempt to predict how severe debris densities and fluxes will become in orbit regimes of interest. Conversely, space operators currently do not treat space debris as a major mission hazard. This survey paper outlines the range of cost and risk evaluations a space operator must consider when determining a debris-related response. Beyond the typical direct costs of performing an avoidance maneuver, the total cost including indirect costs, political costs and space environmental costs are discussed. The weights on these costs can vary drastically across mission types and orbit regimes flown. The operator response options during a mission are grouped into four categories: no action, perform debris dodging, follow stricter mitigation, and employ ADR. Current space operations are only considering the no action and debris dodging options, but increasing debris risk will eventually force the stricter mitigation and ADR options. Debris response equilibria where debris-related risks and costs settle on a steady-state solution are hypothesized.

  18. An Overview of the Performance of the Chandra X-ray Observatory

    NASA Technical Reports Server (NTRS)

    Weisskopf, M. C.; Aldcroft, T. L.; Bautz, M.; Cameron, R. A.; Dewey, D.; Drake, J. J.; Grant, C. E.; Marshall, H. L.; Murray, S. S.

    2004-01-01

    The Chandra X-ray Observatory is the X-ray component of NASA's Great Observatory Program which includes the recently launched Spitzer Infrared Telescope, the Hubble Space Telescope (HST) for observations in the visible, and the Compton Gamma-Ray Observatory (CGRO) which, after providing years of useful data has reentered the atmosphere. All these facilities provide, or provided, scientific data to the international astronomical community in response to peer-reviewed proposals for their use. The Chandra X-ray Observatory was the result of the efforts of many academic, commercial, and government organizations primarily in the United States but also in Europe. NASA s Marshall Space Flight Center (MSFC) manages the Project and provides Project Science; Northrop Grumman Space Technology (NGST - formerly TRW) served as prime contractor responsible for providing the spacecraft, the telescope, and assembling and testing the Observatory; and the Smithsonian Astrophysical Observatory (SAO) provides technical support and is responsible for ground operations including the Chandra X-ray Center (CXC). Telescope and instrument teams at SAO, the Massachusetts Institute of Technology (MIT), the Pennsylvania State University (PSU), the Space Research Institute of the Netherlands (SRON), the Max-Planck Institut fur extraterrestrische Physik (MPE), and the University of Kiel support also provide technical support to the Chandra Project. We present here a detailed description of the hardware, its on-orbit performance, and a brief overview of some of the remarkable discoveries that illustrate that performance.

  19. Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans.

    PubMed

    Strassman, R J; Qualls, C R; Berg, L M

    1996-05-01

    Tolerance of the behavioral effects of the short-acting, endogenous hallucinogen, N,N-dimethyltryptamine (DMT) is seen inconsistently in animals, and has not been produced in humans. The nature and time course of responses to repetitive, closely spaced administrations of an hallucinogenic dose of DMT were characterized. Thirteen experienced hallucinogen users received intravenous 0.3 mg/kg DMT fumarate, or saline placebo, four times, at 30 min intervals, on 2 separate days, in a randomized, double-blind, design. Tolerance to "psychedelic" subjective effects did not occur according to either clinical interview or Hallucinogen Rating Scale scores. Adrenocorticotropic hormone (ACTH), prolactin, cortisol, and heart rate responses decreased with repeated DMT administration, although blood pressure did not. These data demonstrate the unique properties of DMT relative to other hallucinogens and underscore the differential regulation of the multiple processes mediating the effects of DMT.

  20. Triangles in ROC space: History and theory of "nonparametric" measures of sensitivity and response bias.

    PubMed

    Macmillan, N A; Creelman, C D

    1996-06-01

    Can accuracy and response bias in two-stimulus, two-response recognition or detection experiments be measured nonparametrically? Pollack and Norman (1964) answered this question affirmatively for sensitivity, Hodos (1970) for bias: Both proposed measures based on triangular areas in receiver-operating characteristic space. Their papers, and especially a paper by Grier (1971) that provided computing formulas for the measures, continue to be heavily cited in a wide range of content areas. In our sample of articles, most authors described triangle-based measures as making fewer assumptions than measures associated with detection theory. However, we show that statistics based on products or ratios of right triangle areas, including a recently proposed bias index and a not-yetproposed but apparently plausible sensitivity index, are consistent with a decision process based on logistic distributions. Even the Pollack and Norman measure, which is based on non-right triangles, is approximately logistic for low values of sensitivity. Simple geometric models for sensitivity and bias are not nonparametric, even if their implications are not acknowledged in the defining publications.

  1. Monitoring and Correcting Autonomic Function Aboard Mir: NASA Technology Used in Space and on Earth to Facilitate Adaptation

    NASA Technical Reports Server (NTRS)

    Cowings, P.; Toscano, W.; Taylor, B.; DeRoshia, C.; Kornilova, L.; Koslovskaya, I.; Miller, N.

    1999-01-01

    The broad objective of the research was to study individual characteristics of human adaptation to long duration spaceflight and possibilities of their correction using autonomic conditioning. The changes in autonomic state during adaptation to microgravity can have profound effects on the operational efficiency of crewmembers and may result in debilitating biomedical symptoms. Ground-based and inflight experiment results showed that certain responses of autonomic nervous system were correlated with, or consistently preceded, reports of performance decrements or the symptoms. Autogenic-Feedback-Training Exercise (AFTE) is a physiological conditioning method that has been used to train people to voluntary control several of their own physiological responses. The specific objectives were: 1) To study human autonomic nervous system (ANS) responses to sustained exposure to microgravity; 2) To study human behavior/performance changes related to physiology; 3) To evaluate the effectiveness of preflight autonomic conditioning (AFTE) for facilitating adaptation to space and readaptation to Earth; and 4) To archive these data for the NASA Life Sciences Data Archive and thereby make this information available to the international scientific community.

  2. Elucidation of the new generation fluorescent protein tdTomato for space related radiobiological research

    NASA Astrophysics Data System (ADS)

    Chishti, Arif Ali; Baumstark-Khan, Christa; Hellweg, Christine; Reitz, Guenther

    Astronauts in space are exposed to a potentially harmful radiation field, which does not exist in its quality and quantity on earth. Radiation exposure in space can lead to delayed or acute health effects. A successful long-term space mission requires better risk estimation and development of appropriate countermeasures, therefore study of the cellular radiation response is necessary. Ionizing radiation can provoke active cellular responses (cell cycle arrest, DNA repair, apoptosis or other forms of cell type). Exposure to ionizing radiation also activates various signaling pathways in human cells. In the cellular radiation-response, two pivotal signal transduction pathways have to be comprehensively studied i.e. the p53-pathway and NF-κB-pathway. Discovery of fluorescent proteins has revolutionized biological research by making it possible to carry out functional studies in living cells and understanding complex signaling pathways. Previously the green fluorescent proteins EGFP and d2EGFP were used for signaling pathway studies. In this work the new red fluorescent protein tdTomato will be used for comprehensive investigation of NF-κB and other transcription factor activation after exposure of human cells to ionizing radiation (X-rays, heavy ions; space conditions). tdTomato has many advantages over EGFP because of its high fluorescence signals and a better signal/noise ratio in human cells. The previously constructed reporter system with d2EGFP was used to evaluate NF-kB activation after exposure to heavy ion particles of different biological effectiveness. The sensitivity threshold of this system was determined to be 2 particle traversals per cell nucleus. In the current study a more sensitive reporter assay will be constructed using a GAL4-VP16 turbo system that comprises a receptor plasmid and a reporter plasmid. This reporter assay will be designed and constructed with tdTomato and evaluation will be done with different molecular techniques.

  3. Antarctic Space Analog Program

    NASA Technical Reports Server (NTRS)

    Palinkas, Lawrence A; Gunderson, E. K. Eric; Johnson, Jeffrey C.; Holland, Albert W.

    1998-01-01

    The primary aim of this project was to examine group dynamics and individual performance in extreme, isolated environments and identify human factors requirements for long-duration space missions using data collected in an analog environment. Specifically, we wished to determine: 1) the characteristics of social relations in small groups of individuals living and working together in extreme, isolated environments, and 2) the environmental, social and psychological determinants of performance effectiveness in such groups. These two issues were examined in six interrelated studies using data collected in small, isolated research stations in Antarctica from 1963 to the present. Results from these six studies indicated that behavior and performance on long-duration space flights is likely to be seasonal or cyclical, situational, social, and salutogenic in nature. The project responded to two NASA program emphases for FY 1997 as described in the NRA: 1) the primary emphasis of the Behavior and Performance Program on determining long-term individual and group performance responses to space, identifying critical factors affecting those responses and understanding underlying mechanisms involved in behavior and performance, and developing and using ground-based models and analogs for studying space-related behavior and performance; and 2) the emphasis of the Data Analysis Program on extended data analysis. Results from the study were used to develop recommendations for the design and development of pre-flight crew training and in-flight psychological countermeasures for long-duration manned space missions.

  4. Does movement influence representations of time and space?

    PubMed Central

    2017-01-01

    Embodied cognition posits that abstract conceptual knowledge such as mental representations of time and space are at least partially grounded in sensorimotor experiences. If true, then the execution of whole-body movements should result in modulations of temporal and spatial reference frames. To scrutinize this hypothesis, in two experiments participants either walked forward, backward or stood on a treadmill and responded either to an ambiguous temporal question (Experiment 1) or an ambiguous spatial question (Experiment 2) at the end of the walking manipulation. Results confirmed the ambiguousness of the questions in the control condition. Nevertheless, despite large power, walking forward or backward did not influence the answers or response times to the temporal (Experiment 1) or spatial (Experiment 2) question. A follow-up Experiment 3 indicated that this is also true for walking actively (or passively) in free space (as opposed to a treadmill). We explore possible reasons for the null-finding as concerns the modulation of temporal and spatial reference frames by movements and we critically discuss the methodological and theoretical implications. PMID:28376130

  5. Does movement influence representations of time and space?

    PubMed

    Loeffler, Jonna; Raab, Markus; Cañal-Bruland, Rouwen

    2017-01-01

    Embodied cognition posits that abstract conceptual knowledge such as mental representations of time and space are at least partially grounded in sensorimotor experiences. If true, then the execution of whole-body movements should result in modulations of temporal and spatial reference frames. To scrutinize this hypothesis, in two experiments participants either walked forward, backward or stood on a treadmill and responded either to an ambiguous temporal question (Experiment 1) or an ambiguous spatial question (Experiment 2) at the end of the walking manipulation. Results confirmed the ambiguousness of the questions in the control condition. Nevertheless, despite large power, walking forward or backward did not influence the answers or response times to the temporal (Experiment 1) or spatial (Experiment 2) question. A follow-up Experiment 3 indicated that this is also true for walking actively (or passively) in free space (as opposed to a treadmill). We explore possible reasons for the null-finding as concerns the modulation of temporal and spatial reference frames by movements and we critically discuss the methodological and theoretical implications.

  6. Aeromedical Lessons from the Space Shuttle Columbia Accident Investigation

    NASA Technical Reports Server (NTRS)

    Pool, Sam L.

    2005-01-01

    This paper presents the aeromedical lessons learned from the Space Shuttle Columbia Accident Investigation. The contents include: 1) Introduction and Mission Response Team (MRT); 2) Primary Disaster Field Office (DFO); 3) Mishap Investigation Team (MIT); 4) Kennedy Space Center (KSC) Mishap Response Plan; 5) Armed Forces Institute of Pathology (AFIP); and 6) STS-107 Crew Surgeon.

  7. Nonlinear ultrasonic imaging method for closed cracks using subtraction of responses at different external loads.

    PubMed

    Ohara, Yoshikazu; Horinouchi, Satoshi; Hashimoto, Makoto; Shintaku, Yohei; Yamanaka, Kazushi

    2011-08-01

    To improve the selectivity of closed cracks for objects other than cracks in ultrasonic imaging, we propose an extension of a novel imaging method, namely, subharmonic phased array for crack evaluation (SPACE) as well as another approach using the subtraction of responses at different external loads. By applying external static or dynamic loads to closed cracks, the contact state in the cracks varies, resulting in an intensity change of responses at cracks. In contrast, objects other than cracks are independent of external load. Therefore, only cracks can be extracted by subtracting responses at different loads. In this study, we performed fundamental experiments on a closed fatigue crack formed in an aluminum alloy compact tension (CT) specimen using the proposed method. We examined the static load dependence of SPACE images and the dynamic load dependence of linear phased array (PA) images by simulating the external loads with a servohydraulic fatigue testing machine. By subtracting the images at different external loads, we show that this method is useful in extracting only the intensity change of responses related to closed cracks, while canceling the responses of objects other than cracks. Copyright © 2010 Elsevier B.V. All rights reserved.

  8. Responses of Myosin Heavy Chain Phenotypes and Gene Expressions in Neck Muscle to Micro- an Hyper-Gravity in Mice

    NASA Astrophysics Data System (ADS)

    Ohira, Tomotaka; Ohira, Takashi; Kawano, F.; Shibaguchi, T.; Okabe, H.; Ohno, Y.; Nakai, N.; Ochiai, T.; Goto, K.; Ohira, Y.

    2013-02-01

    Neck muscles are known to play important roles in the maintenance of head posture against gravity. However, it is not known how the properties of neck muscle are influenced by gravity. Therefore, the current study was performed to investigate the responses of neck muscle (rhomboideus capitis) in mice to inhibition of gravity and/or increase to 2-G for 3 months to test the hypothesis that the properties of neck muscles are regulated in response to the level of mechanical load applied by the gravitational load. Three male wild type C57BL/10J mice (8 weeks old) were launched by space shuttle Discovery (STS-128) and housed in Japanese Experimental Module “KIBO” on the International Space Station in mouse drawer system (MDS) project, which was organized by Italian Space Agency. Only 1 mouse returned to the Earth alive after 3 months by space shuttle Atlantis (STS-129). Neck muscles were sampled from both sides within 3 hours after landing. Cage and laboratory control experiments were also performed on the ground. Further, 3-month ground-based control experiments were performed with 6 groups, i.e. pre-experiment, 3-month hindlimb suspension, 2-G exposure by using animal centrifuge, and vivarium control (n=5 each group). Five mice were allowed to recover from hindlimb suspension (including 5 cage control) for 3 months in the cage. Neck muscles were sampled bilaterally before and after 3-month suspension and 2-G exposure, and at the end of 3-month ambulation recovery. Spaceflight-associated shift of myosin heavy chain phenotype from type I to II and atrophy of type I fibers were observed. In response to spaceflight, 17 genes were up-regulated and 13 genes were down-regulated vs. those in the laboratory control. Expression of 6 genes were up-regulated and that of 88 genes were down-regulated by 3-month exposure to 2-G vs. the age-matched cage control. In response to chronic hindlimb suspension, 4 and 20 genes were up- or down-regulated. Further, 98 genes responded significantly to both hindlimb unloading and exposure to 2-G. Thirteen genes were up-regulated and 85 were down-regulated. In conclusion, long-term gravitational unloading of mouse caused shift of fiber phenotype toward fast-twitch type and atrophy of slow-twitch fibers in neck muscle. These responses were closely related to the up- or down-regulation of genes, suggesting that oxidative muscular metabolism may be inhibited in microgravity environment.

  9. When the going gets tough: behavioural type-dependent space use in the sleepy lizard changes as the season dries.

    PubMed

    Spiegel, Orr; Leu, Stephan T; Sih, Andrew; Godfrey, Stephanie S; Bull, C Michael

    2015-11-22

    Understanding space use remains a major challenge for animal ecology, with implications for species interactions, disease spread, and conservation. Behavioural type (BT) may shape the space use of individuals within animal populations. Bolder or more aggressive individuals tend to be more exploratory and disperse further. Yet, to date we have limited knowledge on how space use other than dispersal depends on BT. To address this question we studied BT-dependent space-use patterns of sleepy lizards (Tiliqua rugosa) in southern Australia. We combined high-resolution global positioning system (GPS) tracking of 72 free-ranging lizards with repeated behavioural assays, and with a survey of the spatial distributions of their food and refuge resources. Bayesian generalized linear mixed models (GLMM) showed that lizards responded to the spatial distribution of resources at the neighbourhood scale and to the intensity of space use by other conspecifics (showing apparent conspecific avoidance). BT (especially aggressiveness) affected space use by lizards and their response to ecological and social factors, in a seasonally dependent manner. Many of these effects and interactions were stronger later in the season when food became scarce and environmental conditions got tougher. For example, refuge and food availability became more important later in the season and unaggressive lizards were more responsive to these predictors. These findings highlight a commonly overlooked source of heterogeneity in animal space use and improve our mechanistic understanding of processes leading to behaviourally driven disease dynamics and social structure. © 2015 The Author(s).

  10. 43rd Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Boesiger, Edward A.

    2016-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Sponsored and organized by the Mechanisms Education Association, responsibility for hosting the AMS is shared by the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC). Now in its 43rd symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 43rd AMS was held in Santa Clara, California on May 4, 5 and 6, 2016. During these three days, 42 papers were presented. Topics included payload and positioning mechanisms, components such as hinges and motors, CubeSats, tribology, and mechanism testing. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components. The high quality of this symposium is a result of the work of many people, and their efforts are gratefully acknowledged. This extends to the voluntary members of the symposium organizing committee representing the eight NASA field centers, LMSSC, and the European Space Agency. Appreciation is also extended to the session chairs, the authors, and particularly the personnel at ARC responsible for the symposium arrangements and the publication of these proceedings. A sincere thank you also goes to the symposium executive committee who is responsible for the year-to-year management of the AMS, including paper processing and preparation of the program. The use of trade names of manufacturers in this publication does not constitute an official endorsement of such products or manufacturers, either expressed or implied, by the National Aeronautics and Space Administration.

  11. Microgravity-associated Changes in Cellular Signal Processing

    NASA Astrophysics Data System (ADS)

    Mednieks, M. I.; Hand, Arthur

    It has been an ongoing interest in the NASA Life Sciences Division to determine the physiologic effects of space travel and to devise countermeasures to those effects that can be detrimental to humans. In addition to study of animals flown on the US STS-131, 133 and 135 shuttle missions, participating in the Russian COSMOS and BION-M1 missions has provided important opportunities to study the effects of microgravity on hormonal regulation of cell and tissue responses and on a defined molecular basis. A mouse model was employed to study the effects of space flight on regulation of protein secretion in oral fluid. Using morphologic, and molecular methods it was determined that the expression of a number of proteins is altered after space flight when compared to that of controls. Shown by microarray analyses, some salivary gland genes are down regulated, others up-regulated, while the majority are unaffected. Electron microscopic examination of salivary glands showed no overall tissue damage, but specific morphologic effects were seen that are consistent with an increase in apoptosis and altered duct cell function. Immuno-cytochemical and biochemical methods were used to identify the specific proteins. Initial studies indicate that some of the effects appear transient and could be an adjustment or homeostatic response to microgravity conditions. Further studies will determine if a pharmacologic means can serve as a countermeasure to physiologic changes in humans in catecholamine hormone regulated responses due to travel in space. Support: CT Space Grant College Consortium, School of Dental Medicine Alumni Research Fellowship and the NASA Award Number, NNX09AP13G,

  12. 14 CFR 91.1057 - Flight, duty and rest time requirements: All crewmembers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... cabin-safety-related responsibilities. Multi-time zone flight means an easterly or westerly flight or multiple flights in one direction in the same duty period that results in a time zone difference of 5 or... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Flight, duty and rest time requirements...

  13. Radiation response of nanotwinned Cu under multiple-collision cascades

    NASA Astrophysics Data System (ADS)

    Wu, Lianping; Yu, Wenshan; Hu, Shuling; Shen, Shengping

    2018-07-01

    In this paper, multiple collision cascades (MCC) of nanotwinned (nt) Cu with three different twin spacings are performed to model the response of nt Cu upon a radiation dose of 1 displacements per atom (dpa). Considering the defects developed with high randomness in the material during a MCC process, each MCC in a nt Cu is conducted for eight times. This enables us to analyze some average properties of defect clusters in the radiated nt Cu with different twin spacings at the different radiation doses. We also analyze the microstructural evolution in the nt Cu during the MCC. Smaller size of defect clusters and lower defect density are seen in the nt Cu with smaller twin spacing. In addition, a number of defect clusters could be removed via their frequent interactions with the coherent twin boundaries (CTBs) during the MCC. This induces either the migration of CTBs or the healing of CTBs. Moreover, the potential formation and elimination mechanisms of stacking fault are found to be due to the climb of Frank partial dislocation and glide of Shockley partial dislocations. This study provides further evidence on the irradiation tolerance of CTBs and the self-healing capability of CTBs in response to radiation.

  14. Transcriptomic changes in an animal-bacterial symbiosis under modeled microgravity conditions

    PubMed Central

    Casaburi, Giorgio; Goncharenko-Foster, Irina; Duscher, Alexandrea A.; Foster, Jamie S.

    2017-01-01

    Spaceflight imposes numerous adaptive challenges for terrestrial life. The reduction in gravity, or microgravity, represents a novel environment that can disrupt homeostasis of many physiological processes. Additionally, it is becoming increasingly clear that an organism’s microbiome is critical for host health and examining its resiliency in microgravity represents a new frontier for space biology research. In this study, we examine the impact of microgravity on the interactions between the squid Euprymna scolopes and its beneficial symbiont Vibrio fischeri, which form a highly specific binary mutualism. First, animals inoculated with V. fischeri aboard the space shuttle showed effective colonization of the host light organ, the site of the symbiosis, during space flight. Second, RNA-Seq analysis of squid exposed to modeled microgravity conditions exhibited extensive differential gene expression in the presence and absence of the symbiotic partner. Transcriptomic analyses revealed in the absence of the symbiont during modeled microgravity there was an enrichment of genes and pathways associated with the innate immune and oxidative stress response. The results suggest that V. fischeri may help modulate the host stress responses under modeled microgravity. This study provides a window into the adaptive responses that the host animal and its symbiont use during modeled microgravity. PMID:28393904

  15. Environmental Control and Life Support Systems Test Facility at MSFC

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. Scientists and engineers at the MSFC are working together to provide the ISS with systems that are safe, efficient, and cost-effective. These compact and powerful systems are collectively called the Environmental Control and Life Support Systems, or simply, ECLSS. This photograph shows the development Water Processor located in two racks in the ECLSS test area at the Marshall Space Flight Center. Actual waste water, simulating Space Station waste, is generated and processed through the hardware to evaluate the performance of technologies in the flight Water Processor design.

  16. This is NASA

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Highlights of NASA's first 20 years are described including the accomplishments of the National Advisory Committee for Aeronautics from its creation in 1915 until its absorption into NASA in 1958. Current and future activities are assessed in relation to the Federal R&D research plan for FY 1980 and to U.S. civil space policy. A NASA organization chart accompanies descriptions of the responsibilities of Headquarters, its various offices, and field installations. Directions are given for contacting the agency for business activities or contracting purposes; for obtaining educational publications and other media, and for tours. Manpower statistics are included with a list of career opportunities. Special emphasis is given to manned space flight, space launch vehicles, space shuttle, planetary exploration, and investigations of the stars and the solar system.

  17. A Response Function Approach for Rapid Far-Field Tsunami Forecasting

    NASA Astrophysics Data System (ADS)

    Tolkova, Elena; Nicolsky, Dmitry; Wang, Dailin

    2017-08-01

    Predicting tsunami impacts at remote coasts largely relies on tsunami en-route measurements in an open ocean. In this work, these measurements are used to generate instant tsunami predictions in deep water and near the coast. The predictions are generated as a response or a combination of responses to one or more tsunameters, with each response obtained as a convolution of real-time tsunameter measurements and a pre-computed pulse response function (PRF). Practical implementation of this method requires tables of PRFs in a 3D parameter space: earthquake location-tsunameter-forecasted site. Examples of hindcasting the 2010 Chilean and the 2011 Tohoku-Oki tsunamis along the US West Coast and beyond demonstrated high accuracy of the suggested technology in application to trans-Pacific seismically generated tsunamis.

  18. Integrated tracking of components by engineering and logistics utilizing logistics asset tracking system

    NASA Technical Reports Server (NTRS)

    Renfroe, Michael B.; Mcdonald, Edward J.; Bradshaw, Kimberly

    1988-01-01

    The Logistics Asset Tracking System (LATS) devised by NASA contains data on Space Shuttle LRUs that are daily updated to reflect such LRU status changes as repair due to failure or modification due to changing engineering requirements. The implementation of LATS has substantially increased personnel responsiveness, preventing costly delays in Space Shuttle processing and obviating hardware cannibalization. An evaluation is presented of LATS achievements in the direction of an integrated logistical support posture.

  19. Earth Observations taken by Expedition 41 crewmember

    NASA Image and Video Library

    2014-09-13

    ISS041-E-013683 (13 Sept. 2014) --- Photographed with a mounted automated camera, this is one of a number of images featuring the European Space Agency?s Automated Transfer Vehicle (ATV-5 or Georges Lemaitre) docked with the International Space Station. Except for color changes, the images are almost identical. The variation in color from frame to frame is due to the camera?s response to the motion of the orbital outpost, relative to the illumination from the sun.

  20. Earth Observations taken by Expedition 41 crewmember

    NASA Image and Video Library

    2014-09-13

    ISS041-E-013687 (13 Sept. 2014) --- Photographed with a mounted automated camera, this is one of a number of images featuring the European Space Agency?s Automated Transfer Vehicle (ATV-5 or Georges Lemaitre) docked with the International Space Station. Except for color changes, the images are almost identical. The variation in color from frame to frame is due to the camera?s response to the motion of the orbital outpost, relative to the illumination from the sun.

  1. Earth Observations taken by Expedition 41 crewmember

    NASA Image and Video Library

    2014-09-13

    ISS041-E-013693 (13 Sept. 2014) --- Photographed with a mounted automated camera, this is one of a number of images featuring the European Space Agency?s Automated Transfer Vehicle (ATV-5 or Georges Lemaitre) docked with the International Space Station. Except for color changes, the images are almost identical. The variation in color from frame to frame is due to the camera?s response to the motion of the orbital outpost, relative to the illumination from the sun.

  2. KSC-03PD-3145

    NASA Technical Reports Server (NTRS)

    2003-01-01

    KENNEDY SPACE CENTER, FLA. Officials of the NASA-Kennedy Space Center and the state of Florida pose for a group portrait at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab at the new lab. From left are Capt. Winston Scott, executive director of the Florida Space Authority; Dr. Robert J. Ferl, director of Space Agriculture Biotechnology Research and Education (SABRE), University of Florida; Charlie Quincy, chief of the Biological Sciences Office, Kennedy Space Center; Jose Perez-Morales, NASA Project Manager for the Space Life Sciences Lab; Jim Kennedy, director of the Kennedy Space Center; The Honorable Toni Jennings, lieutenant governor of the state of Florida; Frank T. Brogan, president of the Florida Atlantic University; and Dr. Samuel Durrance, executive director of the Florida Space Research Institute. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASAs Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

  3. Effects of spacing of item repetitions in continuous recognition memory: does item retrieval difficulty promote item retention in older adults?

    PubMed

    Kılıç, Aslı; Hoyer, William J; Howard, Marc W

    2013-01-01

    BACKGROUND/STUDY CONTEXT: Older adults exhibit an age-related deficit in item memory as a function of the length of the retention interval, but older adults and young adults usually show roughly equivalent benefits due to the spacing of item repetitions in continuous memory tasks. The current experiment investigates the seemingly paradoxical effects of retention interval and spacing in young and older adults using a continuous recognition memory procedure. Fifty young adults and 52 older adults gave memory confidence ratings to words that were presented once (P1), twice (P2), or three times (P3), and the effects of the lag length and retention interval were assessed at P2 and at P3, respectively. Response times at P2 were disproportionately longer for older adults than for younger adults as a function of the number of items occurring between P1 and P2, suggestive of age-related loss in item memory. Ratings of confidence in memory responses revealed that older adults remembered fewer items at P2 with a high degree of certainty. Confidence ratings given at P3 suggested that young and older adults derived equivalent benefits from the spacing between P1 and P2. Findings of this study support theoretical accounts that suggest that recursive reminding and/or item retrieval difficulty promote item retention in older adults.

  4. Retrieval Practice and Spacing Effects in Young and Older Adults: An Examination of the Benefits of Desirable Difficulty

    PubMed Central

    Maddox, Geoffrey B.; Balota, David A.

    2015-01-01

    The present study examined how the function relating continued retrieval practice (e.g., 1, 3, or 5 tests) and long-term memory retention is modulated by desirable difficulty (Bjork, 1994). Of particular interest was how retrieval difficulty differed across young and older adults and across manipulations of lag (Experiment 1) and spacing (Experiment 2). To extend on previous studies, acquisition phase response latency was used as a proxy for retrieval difficulty, and analysis of final test performance was conditionalized on acquisition phase retrieval success to more directly examine the influence of desirable difficulty on retention. Results from Experiment 1 revealed that continued testing in the short lag condition led to consistent increases in retention, whereas continued testing in the long lag condition led to increasingly smaller benefits in retention for both age groups. Results from Experiment 2 revealed that repeated spaced testing enhanced retention relative to taking one spaced test for both age groups; however, repeated massed testing only enhanced retention over taking one test for young adults. Across both experiments, the response latency results were overall consistent with an influence of desirable difficulty on retention. Discussion focuses on the role of desirable difficulty during encoding in producing the benefits of lag, spacing, and testing. PMID:25616776

  5. Rapid Transient Pressure Field Computations in the Nearfield of Circular Transducers using Frequency Domain Time-Space Decomposition

    PubMed Central

    Alles, E. J.; Zhu, Y.; van Dongen, K. W. A.; McGough, R. J.

    2013-01-01

    The fast nearfield method, when combined with time-space decomposition, is a rapid and accurate approach for calculating transient nearfield pressures generated by ultrasound transducers. However, the standard time-space decomposition approach is only applicable to certain analytical representations of the temporal transducer surface velocity that, when applied to the fast nearfield method, are expressed as a finite sum of products of separate temporal and spatial terms. To extend time-space decomposition such that accelerated transient field simulations are enabled in the nearfield for an arbitrary transducer surface velocity, a new transient simulation method, frequency domain time-space decomposition (FDTSD), is derived. With this method, the temporal transducer surface velocity is transformed into the frequency domain, and then each complex-valued term is processed separately. Further improvements are achieved by spectral clipping, which reduces the number of terms and the computation time. Trade-offs between speed and accuracy are established for FDTSD calculations, and pressure fields obtained with the FDTSD method for a circular transducer are compared to those obtained with Field II and the impulse response method. The FDTSD approach, when combined with the fast nearfield method and spectral clipping, consistently achieves smaller errors in less time and requires less memory than Field II or the impulse response method. PMID:23160476

  6. Microgravity-driven remodeling of the proteome reveals insights into molecular mechanisms and signal networks involved in response to the space flight environment.

    PubMed

    Rea, Giuseppina; Cristofaro, Francesco; Pani, Giuseppe; Pascucci, Barbara; Ghuge, Sandip A; Corsetto, Paola Antonia; Imbriani, Marcello; Visai, Livia; Rizzo, Angela M

    2016-03-30

    Space is a hostile environment characterized by high vacuum, extreme temperatures, meteoroids, space debris, ionospheric plasma, microgravity and space radiation, which all represent risks for human health. A deep understanding of the biological consequences of exposure to the space environment is required to design efficient countermeasures to minimize their negative impact on human health. Recently, proteomic approaches have received a significant amount of attention in the effort to further study microgravity-induced physiological changes. In this review, we summarize the current knowledge about the effects of microgravity on microorganisms (in particular Cupriavidus metallidurans CH34, Bacillus cereus and Rhodospirillum rubrum S1H), plants (whole plants, organs, and cell cultures), mammalian cells (endothelial cells, bone cells, chondrocytes, muscle cells, thyroid cancer cells, immune system cells) and animals (invertebrates, vertebrates and mammals). Herein, we describe their proteome's response to microgravity, focusing on proteomic discoveries and their future potential applications in space research. Space experiments and operational flight experience have identified detrimental effects on human health and performance because of exposure to weightlessness, even when currently available countermeasures are implemented. Many experimental tools and methods have been developed to study microgravity induced physiological changes. Recently, genomic and proteomic approaches have received a significant amount of attention. This review summarizes the recent research studies of the proteome response to microgravity inmicroorganisms, plants, mammalians cells and animals. Current proteomic tools allow large-scale, high-throughput analyses for the detection, identification, and functional investigation of all proteomes. Understanding gene and/or protein expression is the key to unlocking the mechanisms behind microgravity-induced problems and to finding effective countermeasures to spaceflight-induced alterations but also for the study of diseases on earth. Future perspectives are also highlighted. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Load responsive hydrodynamic bearing

    DOEpatents

    Kalsi, Manmohan S.; Somogyi, Dezso; Dietle, Lannie L.

    2002-01-01

    A load responsive hydrodynamic bearing is provided in the form of a thrust bearing or journal bearing for supporting, guiding and lubricating a relatively rotatable member to minimize wear thereof responsive to relative rotation under severe load. In the space between spaced relatively rotatable members and in the presence of a liquid or grease lubricant, one or more continuous ring shaped integral generally circular bearing bodies each define at least one dynamic surface and a plurality of support regions. Each of the support regions defines a static surface which is oriented in generally opposed relation with the dynamic surface for contact with one of the relatively rotatable members. A plurality of flexing regions are defined by the generally circular body of the bearing and are integral with and located between adjacent support regions. Each of the flexing regions has a first beam-like element being connected by an integral flexible hinge with one of the support regions and a second beam-like element having an integral flexible hinge connection with an adjacent support region. A least one local weakening geometry of the flexing region is located intermediate the first and second beam-like elements. In response to application of load from one of the relatively rotatable elements to the bearing, the beam-like elements and the local weakening geometry become flexed, causing the dynamic surface to deform and establish a hydrodynamic geometry for wedging lubricant into the dynamic interface.

  8. The Virginia Space Flight Center model for an integrated federal/commercial launch range

    NASA Astrophysics Data System (ADS)

    Reed, Billie M.

    2000-01-01

    Until 1998, the federal government has been the predominant purchaser of space launches in the U.S. through the purchase of hardware and services. Historically, the government provided the necessary infrastructure for launches from the federal DoD and NASA launch ranges. In this historical model, the federal government had complete ownership, responsibility, liability, and expense for launch activities. In 1998, commercial space launches accounted for 60% of U.S. launches. This growth in commercial launches has increased the demand for launch range services. However, the expense, complexity of activities, and issues over certification of flight safety have deterred the establishment of purely commercial launch sites, with purely commercial being defined as without benefit of capabilities provided by the federal government. Provisions of the Commercial Space Launch Act have enabled DoD and NASA to support commercial launches from government launch ranges on a cost-reimbursable, non-interference basis. The government provides services including use of facilities, tracking and data services, and range and flight safety. In the 1990's, commercial space market projections indicated strong potential for large numbers of commercial satellites to be launched well into the first decade of the 21st century. In response to this significant opportunity for economic growth, several states established spaceports to provide the services necessary to meet these forecast commercial needs. In 1997, NASA agreed to the establishment of the Virginia Space Flight Center (VSFC), a commercial spaceport, at its Wallops Flight Facility. Under this arrangement, NASA agreed to allow the Virginia Commercial Space Flight Authority (VCSFA) to construct facilities on NASA property and agreed to provide launch range and other services in accordance with the Space Act and Commercial Space Launch Act in support of VSFC launch customers. A partnership relationship between NASA and VCSFA has emerged which pairs the strengths of the established NASA Test Range and the state-sponsored, commercial launch facility provider in an attempt to satisfy the needs for flexible, low-cost access to space. The continued viability of the VSFC and other commercial spaceports depend upon access to a space launch and re-entry range safety system that assures the public safety and is accepted by the public and government as authoritative and reliable. DoD and NASA budget problems have resulted in deteriorating services and reliability at federal ranges and has caused fear with respect to their ability to service the growing commercial market. Numerous high level studies have been conducted or are in progress that illuminate the deficiencies. No federal agency has been provided the necessary funding or authority to address the nations diminishing space launch capability. It is questionable as to whether the U.S. can continue to compete in the global space launch market unless these domestic space access problems are rapidly corrected. This paper discusses a potential solution to the lack of a coordinated response in the U.S. to the challenge presented by the global market for space launch facilities and services. .

  9. Modal identification of structures from the responses and random decrement signatures

    NASA Technical Reports Server (NTRS)

    Brahim, S. R.; Goglia, G. L.

    1977-01-01

    The theory and application of a method which utilizes the free response of a structure to determine its vibration parameters is described. The time-domain free response is digitized and used in a digital computer program to determine the number of modes excited, the natural frequencies, the damping factors, and the modal vectors. The technique is applied to a complex generalized payload model previously tested using sine sweep method and analyzed by NASTRAN. Ten modes of the payload model are identified. In case free decay response is not readily available, an algorithm is developed to obtain the free responses of a structure from its random responses, due to some unknown or known random input or inputs, using the random decrement technique without changing time correlation between signals. The algorithm is tested using random responses from a generalized payload model and from the space shuttle model.

  10. Actions Needed to Ensure Scientific and Technical Information is Adequately Reviewed at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    2008-01-01

    This audit was initiated in response to a hotline complaint regarding the review, approval, and release of scientific and technical information (STI) at Johnson Space Center. The complainant alleged that Johnson personnel conducting export control reviews of STI were not fully qualified to conduct those reviews and that the reviews often did not occur until after the STI had been publicly released. NASA guidance requires that STI, defined as the results of basic and applied scientific, technical, and related engineering research and development, undergo certain reviews prior to being released outside of NASA or to audiences that include foreign nationals. The process includes technical, national security, export control, copyright, and trade secret (e.g., proprietary data) reviews. The review process was designed to preclude the inappropriate dissemination of sensitive information while ensuring that NASA complies with a requirement of the National Aeronautics and Space Act of 1958 (the Space Act)1 to provide for the widest practicable and appropriate dissemination of information resulting from NASA research activities. We focused our audit on evaluating the STI review process: specifically, determining whether the roles and responsibilities for the review, approval, and release of STI were adequately defined and documented in NASA and Center-level guidance and whether that guidance was effectively implemented at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center. Johnson was included in the review because it was the source of the initial complaint, and Goddard, Langley, and Marshall were included because those Centers consistently produce significant amounts of STI.

  11. Applications of particle microbeams in space radiation research.

    PubMed

    Durante, Marco

    2009-03-01

    Galactic cosmic radiation is acknowledged as one of the major barriers to human space exploration. In space, astronauts are exposed to charged particles from Z = 1 (H) up to Z = 28 (Ni), but the probability of a hit to a specific single cell in the human body is low. Particle microbeams can deliver single charged particles of different charge and energy to single cells from different tissues, and microbeam studies are therefore very useful for improving current risk estimates for long-term space travel. 2D in vitro cell cultures can be very useful for establishing basic molecular mechanisms, but they are not sufficient to extrapolate risk, given the substantial evidence proving tissue effects are key in determining the response to radiation insult. 3D tissue or animal systems represent a more promising target for space radiobiology using microbeams.

  12. Adiabatic Invariant Approach to Transverse Instability: Landau Dynamics of Soliton Filaments.

    PubMed

    Kevrekidis, P G; Wang, Wenlong; Carretero-González, R; Frantzeskakis, D J

    2017-06-16

    Consider a lower-dimensional solitonic structure embedded in a higher-dimensional space, e.g., a 1D dark soliton embedded in 2D space, a ring dark soliton in 2D space, a spherical shell soliton in 3D space, etc. By extending the Landau dynamics approach [Phys. Rev. Lett. 93, 240403 (2004)PRLTAO0031-900710.1103/PhysRevLett.93.240403], we show that it is possible to capture the transverse dynamical modes (the "Kelvin modes") of the undulation of this "soliton filament" within the higher-dimensional space. These are the transverse stability or instability modes and are the ones potentially responsible for the breakup of the soliton into structures such as vortices, vortex rings, etc. We present the theory and case examples in 2D and 3D, corroborating the results by numerical stability and dynamical computations.

  13. Application of USNRC NUREG/CR-6661 and draft DG-1108 to evolutionary and advanced reactor designs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chang 'Apollo', Chen

    2006-07-01

    For the seismic design of evolutionary and advanced nuclear reactor power plants, there are definite financial advantages in the application of USNRC NUREG/CR-6661 and draft Regulatory Guide DG-1108. NUREG/CR-6661, 'Benchmark Program for the Evaluation of Methods to Analyze Non-Classically Damped Coupled Systems', was by Brookhaven National Laboratory (BNL) for the USNRC, and Draft Regulatory Guide DG-1108 is the proposed revision to the current Regulatory Guide (RG) 1.92, Revision 1, 'Combining Modal Responses and Spatial Components in Seismic Response Analysis'. The draft Regulatory Guide DG-1108 is available at http://members.cox.net/apolloconsulting, which also provides a link to the USNRC ADAMS site to searchmore » for NUREG/CR-6661 in text file or image file. The draft Regulatory Guide DG-1108 removes unnecessary conservatism in the modal combinations for closely spaced modes in seismic response spectrum analysis. Its application will be very helpful in coupled seismic analysis for structures and heavy equipment to reduce seismic responses and in piping system seismic design. In the NUREG/CR-6661 benchmark program, which investigated coupled seismic analysis of structures and equipment or piping systems with different damping values, three of the four participants applied the complex mode solution method to handle different damping values for structures, equipment, and piping systems. The fourth participant applied the classical normal mode method with equivalent weighted damping values to handle differences in structural, equipment, and piping system damping values. Coupled analysis will reduce the equipment responses when equipment, or piping system and structure are in or close to resonance. However, this reduction in responses occurs only if the realistic DG-1108 modal response combination method is applied, because closely spaced modes will be produced when structure and equipment or piping systems are in or close to resonance. Otherwise, the conservatism in the current Regulatory Guide 1.92, Revision 1, will overshadow the advantage of coupled analysis. All four participants applied the realistic modal combination method of DG-1108. Consequently, more realistic and reduced responses were obtained. (authors)« less

  14. Marshall Space Flight Center's role in EASE/ACCESS mission management

    NASA Technical Reports Server (NTRS)

    Hawkins, Gerald W.

    1987-01-01

    The Marshall Space Flight Center (MSFC) Spacelab Payload Project Office was responsible for the mission management and development of several successful payloads. Two recent space construction experiments, the Experimental Assembly of Structures in Extravehicular Activity (EASE) and the Assembly Concept for Construction of Erectable Space Structures (ACCESS), were combined into a payload managed by the center. The Ease/ACCESS was flown aboard the Space Shuttle Mission 61-B. The EASE/ACCESS experiments were the first structures assembled in space, and the method used to manage this successful effort will be useful for future space construction missions. The MSFC mission management responsibilities for the EASE/ACCESS mission are addressed and how the lessons learned from the mission can be applied to future space construction projects are discussed.

  15. Experiment K-7-23: Effect of Spaceflight on Level and Function of Immune Cells. Part 2; Proliferation and Cytokines

    NASA Technical Reports Server (NTRS)

    Nash, P. V.; Konstantinova, I. V.; Fuchs, B. B.; Rakhmilevich, A. L.; Lesnyak, A. T.; Mastro, A. M.

    1994-01-01

    Lymphocytes from the superficial inguinal lymph nodes of rats flown on the Cosmos 2044 space mission were tested for proliferation in response to polyclonal activators. Cells were cultured with T or B cell mitogens, phorbol ester and calcium ionophore, or T cell mitogen and the lymphokines interleukin-1 (IL-1) or interleukin-2 (IL-2), and assayed for DNA synthesis by (3)H-thymidine incorporation. Lymphocytes also were incubated with concanavalin A (Con A), a T cell mitogen, and tested for IL-2 production. Mitogen-stimulated proliferation of lymphocytes from rats exposed to microgravity was not significantly different from synchronous or vivarium controls. Responses to Con A and IL-2, and Con A and IL-1 likewise were unaffected by space flight. Lymphocytes from all of these groups responded well to phorbol ester and calcium ionophore stimulation. Furthermore, lymph node cells (LNC) from control rats and rats flown on Cosmos 2044 produced similar amounts of IL-2. The results obtained using hindlimb suspended rats were notably different from those of flight and control animals. LNC from suspended rats generally had greater proliferative responses to T cell mitogens than did lymphocytes from other groups. Responsiveness to a B cell mitogen was not enhanced. Con A-stimulated LNC from hindlimb suspended rats also produced more IL-2 than did lymphocytes from the other groups. This difference was statistically significant at both IL-2 induction times tested.

  16. Neurodynamics With Spatial Self-Organization

    NASA Technical Reports Server (NTRS)

    Zak, Michail A.

    1993-01-01

    Report presents theoretical study of dynamics of neural network organizing own response in both phase space and in position space. Postulates several mathematical models of dynamics including spatial derivatives representing local interconnections among neurons. Shows how neural responses propagate via these interconnections and how spatial pattern of neural responses formed in homogeneous biological neural network.

  17. Adaptation to vestibular disorientation. XII, Habituation of vestibular responses : an overview.

    DOT National Transportation Integrated Search

    1974-03-01

    Vestibular and visual mechanisms are critical sensing systems in spatial orientation and in spatial disorientation. In aviation or space environments in particular, the role of the vestibular system is central to the problems of spatial disorientatio...

  18. Florida spaceports : an analysis of the regulatory framework.

    DOT National Transportation Integrated Search

    2010-12-16

    The purpose of this project is to look at international, federal, and state law related to commercial space : travel in relation to rights and responsibilities the Florida Department of Transportation may have for : implementing new regulations or re...

  19. Asymmetric Cooperative Communications Based Spectrum Leasing via Auctions in Cognitive Radio Networks

    DTIC Science & Technology

    2011-08-01

    level of responsibility for design activities and program management. He has authored or co-authored numerous papers on designs for space and radiation effects. Mr. Avery is a member of IEEE/ NPSS and AIAA.

  20. Histopathological Alterations after Single Epidural Injection of Ropivacaine, Methylprednizolone Acetate, or Contrast Material in Swine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kitsou, Maria-Chrysanthi; Kostopanagiotou, Georgia; Kalimeris, Konstantinos

    Purpose: The consequences from the injection of different types of drugs in the epidural space remains unknown. Increasing evidence suggests that localized inflammation, fibrosis, and arachnoiditis can complicate sequential epidural blockades, or even epidural contrast injection. We investigate the in vivo effect of epidural injections in the epidural space in an animal model. Materials and Methods: A group of ten male adult pigs, five punctures to each at distinct vertebral interspaces under general anesthesia, were examined, testing different drugs, used regularly in the epidural space (iopamidol, methylprednisolone acetate, ropivacaine). Each site was marked with a percutaneous hook wire marker. Histologicalmore » analysis of the epidural space, the meninges, and the underlying spinal cord of the punctured sites along with staining for caspase-3 followed 20 days later. Results: The epidural space did not manifest adhesions or any other pathology, and the outer surface of the dura was not impaired in any specimen. The group that had the contrast media injection showed a higher inflammation response compared to the other groups (P = 0.001). Positive staining for caspase-3 was limited to <5% of neurons with all substances used. Conclusion: No proof of arachnoiditis and/or fibrosis was noted in the epidural space with the use of the above-described drugs. A higher inflammation rate was noted with the use of contrast media.« less

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