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Sample records for restless quiescence thermonuclear

  1. Restless Leg Syndrome in Neurologic and Medical Disorders.

    PubMed

    Askenasy, Nadir; Askenasy, Jean-Jacques

    2015-09-01

    Adopting prior models of sleep-wake transitions, a flip-flop switch in synchronized neurotransmitter activity is proposed to underlie restless leg syndrome onset. In this model, leg quiescence homeostasis sustained through concerted activities of several neurotransmitters in basal ganglia is perturbed and produces striatal motor activity along sensory activity associated with thalamocortical circuits (conscious urge and discomfort). This model explains the association of restless leg syndrome with a wide variety of associated pathologies emphasizing that perturbed function and imbalance may occur under different steady states of neurotransmitter levels. Likewise, this concept links various central and peripheral etiologies and integrates the augmenting and transient effects of therapeutic neuromodulators.

  2. Nucleosynthesis in Thermonuclear Supernovae

    SciTech Connect

    Claudia, Travaglio; Hix, William Raphael

    2013-01-01

    We review our understanding of the nucleosynthesis that occurs in thermonuclear supernovae and their contribution to Galactic Chemical evolution. We discuss the prospects to improve the modeling of the nucleosynthesis within simulations of these events.

  3. Pathway parameter and thermonuclear functions

    NASA Astrophysics Data System (ADS)

    Mathai, A. M.; Haubold, H. J.

    2008-04-01

    In the theory of thermonuclear reaction rates, analytical evaluation of thermonuclear functions for non-resonant reactions, including cases with cut-off and depletion of the tail of the Maxwell-Boltzmann distribution function were considered in a series of papers by Mathai and Haubold [A.M. Mathai, H.J. Haubold, Modern Problems in Nuclear and Neutrino Astrophysics, Akademie-Verlag, Berlin, 1988]. In the present paper we study more general classes of thermonuclear functions by introducing a pathway parameter α, so that when α→1 the thermonuclear functions in the Maxwell-Boltzmannian case are recovered. We will also give interpretations for the pathway parameter α in the case of cut-off and in terms of moments. Non-extensive statistical mechanics, as developed by Tsallis [C. Tsallis, What should a statistical mechanics satisfy to reflect nature? Physica D 193 (2004) 3-34], provides the physical basis for the generalized thermonuclear functions considered in this paper.

  4. Restless legs syndrome.

    PubMed

    Miletić, Vladimir; Relja, Maja

    2011-12-01

    Being of the most frequent causes of insomnia, which in the end leads to chronic fatigue, inadequate performance of daily activities, and serious disruption of quality of living, restless legs syndrome (RLS) is nowadays not only a serious medical problem but a socio-economical one as well. Prevalence of the disorder in general population is estimated at 5 to 15%. Family history is positive in over 50% of idiopathic RLS patients which points to genetic basis of the disorder. The characteristics of the secondary or acquired form of RLS are symptoms that start later in life as well as a rapid progression of the disease. On the other hand, idiopathic RLS more often starts at a younger age and the prognoses are better. Over twenty disorders and conditions are brought in connection with secondary RLS. Although the cause of primary RLS is still unknown, there is a strong connection between central metabolism of iron as well as dopamine levels and RLS manifestation. A differential diagnosis of RLS includes a wide specter of motor and sensory disorders. Diagnosis is based on clinical features and the history of disease. To correctly diagnose idiopathic RLS one must first eliminate secondary causes of RLS and then also exclude any disorders with clinical features that mimic those of RLS. It has been estimated that some 20 to 25% of patients need pharmacological therapy. Best initial therapy is the application of nonergot dopamine agonists. Anticonvulsants, benzodiazepines and opioides can be given to patients who are refractory to dopaminergic therapy, those suffering from RLS with emphasized painful sensory component and those with RLS connected with insomnia.

  5. ASI regulates satiety quiescence in C. elegans.

    PubMed

    Gallagher, Thomas; Kim, Jeongho; Oldenbroek, Marieke; Kerr, Rex; You, Young-Jai

    2013-06-05

    In Caenorhabditis elegans, satiety quiescence mimics behavioral aspects of satiety and postprandial sleep in mammals. On the basis of calcium-imaging, genetics, and behavioral studies, here we report that a pair of amphid neurons, ASI, is activated by nutrition and regulates worms' behavioral states specifically promoting satiety quiescence; ASI inhibits the switch from quiescence to dwelling (a browsing state) and accelerates the switch from dwelling to quiescence. The canonical TGFβ pathway, whose ligand is released from ASI, regulates satiety quiescence. The mutants of a ligand, a receptor and SMADs in the TGFβ pathway all eat more and show less quiescence than wild-type. The TGFβ receptor in downstream neurons RIM and RIC is sufficient for worms to exhibit satiety quiescence, suggesting neuronal connection from ASI to RIM and RIC is essential for feeding regulation through the TGFβ pathway. ASI also regulates satiety quiescence partly through cGMP signaling; restoring cGMP signaling in ASI rescues the satiety quiescence defect of cGMP signaling mutants. From these results, we propose that TGFβ and cGMP pathways in ASI connect nutritional status to promotion of satiety quiescence, a sleep-like behavioral state.

  6. ASI regulates satiety quiescence in C. elegans

    PubMed Central

    Gallagher, Thomas; Kim, Jeongho; Oldenbroek, Marieke; Kerr, Rex; You, Young-Jai

    2013-01-01

    In C. elegans, satiety quiescence mimics behavioral aspects of satiety and post-prandial sleep in mammals. On the basis of calcium-imaging, genetics and behavioral studies, here we report that a pair of amphid neurons ASI is activated by nutrition and regulates worms’ behavioral states specifically promoting satiety quiescence; ASI inhibits the switch from quiescence to dwelling (a browsing state) and accelerates the switch from dwelling to quiescence. The canonical TGFβ pathway, whose ligand is released from ASI, regulates satiety quiescence. The mutants of a ligand, a receptor and SMADs in the TGFβ pathway all eat more and show less quiescence than wild type. The TGFβ receptor in downstream neurons RIM and RIC is sufficient for worms to exhibit satiety quiescence, suggesting neuronal connection from ASI to RIM and RIC is essential for feeding regulation through the TGFβ pathway. ASI also regulates satiety quiescence partly through cGMP signaling; restoring cGMP signaling in ASI rescues the satiety quiescence defect of cGMP signaling mutants. From these results, we propose that TGFβ and cGMP pathways in ASI connect nutritional status to promotion of satiety quiescence, a sleep-like behavioral state. PMID:23739968

  7. Restless Legs Syndrome and Leg Motor Restlessness in Parkinson's Disease

    PubMed Central

    Suzuki, Keisuke; Miyamoto, Masayuki; Miyamoto, Tomoyuki; Hirata, Koichi

    2015-01-01

    Sleep disturbances are important nonmotor symptoms in Parkinson's disease (PD) that are associated with a negative impact on quality of life. Restless legs syndrome (RLS), which is characterized by an urge to move the legs accompanied by abnormal leg sensations, can coexist with PD, although the pathophysiology of these disorders appears to be different. RLS and PD both respond favorably to dopaminergic treatment, and several investigators have reported a significant relationship between RLS and PD. Sensory symptoms, pain, motor restlessness, akathisia, and the wearing-off phenomenon observed in PD should be differentiated from RLS. RLS in PD may be confounded by chronic dopaminergic treatment; thus, more studies are needed to investigate RLS in drug-naïve patients with PD. Recently, leg motor restlessness (LMR), which is characterized by an urge to move the legs that does not fulfill the diagnostic criteria for RLS, has been reported to be observed more frequently in de novo patients with PD than in age-matched healthy controls, suggesting that LMR may be a part of sensorimotor symptoms intrinsic to PD. In this paper, we provide an overview of RLS, LMR, and PD and of the relationships among these disorders. PMID:26504610

  8. Transient nuclear Prospero induces neural progenitor quiescence

    PubMed Central

    Lai, Sen-Lin; Doe, Chris Q

    2014-01-01

    Stem cells can self-renew, differentiate, or enter quiescence. Understanding how stem cells switch between these states is highly relevant for stem cell-based therapeutics. Drosophila neural progenitors (neuroblasts) have been an excellent model for studying self-renewal and differentiation, but quiescence remains poorly understood. In this study, we show that when neuroblasts enter quiescence, the differentiation factor Prospero is transiently detected in the neuroblast nucleus, followed by the establishment of a unique molecular profile lacking most progenitor and differentiation markers. The pulse of low level nuclear Prospero precedes entry into neuroblast quiescence even when the timing of quiescence is advanced or delayed by changing temporal identity factors. Furthermore, loss of Prospero prevents entry into quiescence, whereas a pulse of low level nuclear Prospero can drive proliferating larval neuroblasts into quiescence. We propose that Prospero levels distinguish three progenitor fates: absent for self-renewal, low for quiescence, and high for differentiation. DOI: http://dx.doi.org/10.7554/eLife.03363.001 PMID:25354199

  9. Restless Legs Syndrome -- Causes and Symptoms

    MedlinePlus

    ... of restless legs syndrome varies from person to person. In some cases the cause is unknown, or it can be caused by or made worse by other health issues or medication. This may include: Low iron levels This can cause problems with brain cell communication that can lead to restless legs syndrome. ...

  10. Genetics Home Reference: restless legs syndrome

    MedlinePlus

    ... T, Wichmann HE, Müller-Myhsok B, Meitinger T. Genome-wide association study identifies novel restless legs syndrome susceptibility loci on ... HE, Holsboer F, Müller-Myhsok B, Meitinger T. Genome-wide association study of restless legs syndrome identifies common variants in ...

  11. Drug-induced restless legs syndrome.

    PubMed

    2010-08-01

    Restless legs syndrome can be very troublesome but it has no serious physical complications. The underlying causes are unknown, but it can be triggered or aggravated by a drug. In early 2010, about 60 cases of drug-induced restless legs syndrome had been published in detail. The drugs implicated were mainly psychotropics, especially antidepressants and neuroleptics. Some drugs used to treat restless legs syndrome, especially dopaminergic drugs, can in fact aggravate symptoms. Drug-induced restless legs syndrome generally resolves when the dose is reduced or the drug is withdrawn. Dysfunction of the dopaminergic system has been implicated in some cases. In practice, when a patient presents with restless legs syndrome, the role of a drug, especially a psychotropic, should be considered. Drug withdrawal or a dose reduction may be beneficial.

  12. Rotigotine for restless legs syndrome.

    PubMed

    Davies, Shelley

    2009-09-01

    Restless legs syndrome (RLS) is a neurological disorder related to abnormal and unpleasant sensations and movements in the legs. It usually occurs at nighttime and thus has a detrimental impact on the ability to sleep, leading to poor patient quality of life. UCB has been developing rotigotine transdermal patch system (Neupro; SPM-962) as a treatment for RLS. This system is designed to replace levels of dopamine in the body via once-daily application of the patch, in a bid to restore proper motor functioning. The rotigotine patch has been authorized for the treatment of RLS since August 2008.

  13. Restless legs syndrome mimicking S1 radiculopathy.

    PubMed

    Zambelis, Th; Wolgamuth, B R; Papoutsi, S N; Economou, N T

    2016-01-01

    Α case of a chronic idiopathic form of a severe type of Restless Legs Syndrome (RLS), which developed during pregnancy and persisted after this, misdiagnosed for 34 years as radiculopathy S1, is reported. In spite of the thorough clinical and laboratory investigation, in addition to constant changes of the therapeutic approach, the diagnosis of S1 radiculopathy could not be confirmed, resulting in a chronic clinical course; the latter was characterized by relapses and remissions not attributed or linked in any way to the treatment (various types of). In fact, it was due to a routine workup in a sleep clinic, where the patient was referred because of a coincident chronic insomnia (Restless Legs Syndrome is a known and important cause of insomnia/chronic insomnia), which resulted in a proper diagnosis and treatment of this case. With the use of Restless Legs Syndrome appropriate treatment (Pramipexole 0.18 mg taken at bedtime, a dopaminergic agent and Level A recommended drug for Restless Legs Syndrome) an excellent response and immediate elimination of symptoms was achieved. Restless Legs Syndrome may present with a variety of symptoms (with the most prominent shortly being reported with the acronym URGE: Urge to move the legs usually associated with unpleasant leg sensations, Rest induces symptoms, Getting active brings relief, Evening and night deteriorate symptoms); given the fact that Restless Legs Syndrome presents with a great variety and heterogeneity of symptoms (mostly pain, dysesthesia and paresthesia), which may occur in several other diseases (the so called "RLS mimics"), proper diagnosis of Restless Legs Syndrome usually fails. Restless Legs Syndrome misinterpreted as S1 radiculopathy, to the best of our knowledge, has not been reported yet in the literature. Here, case history, clinical course and common RLS mimics are presented. Different forms of Restless Legs Syndrome manifestations, which are commonly -as in this case- misinterpreted due to their

  14. Tidally-Induced Thermonuclear Supernovae

    SciTech Connect

    Rosswog, S.; Ramirez-Ruiz, E.; Hix, William Raphael

    2009-01-01

    We discuss the results of 3D simulations of tidal disruptions of white dwarfs by moderate-mass black holes as they may exist in the cores of globular clusters or dwarf galaxies. Our simulations follow self-consistently the hydrodynamic and nuclear evolution from the initial parabolic orbit over the disruption to the build-up of an accretion disk around the black hole. For strong enough encounters (pericentre distances smaller than about 1/3 of the tidal radius) the tidal compression is reversed by a shock and finally results in a thermonuclear explosion. These explosions are not restricted to progenitor masses close to the Chandrasekhar limit, we find exploding examples throughout the whole white dwarf mass range. There is, however, a restriction on the masses of the involved black holes: black holes more massive than 2x105M{circle_dot} swallow a typical 0.6M{circle_dot} white dwarf before their tidal forces can overwhelm the star's selfgravity. Therefore, this mechanism is characteristic for black holes of moderate masses. The material that remains bound to the black hole settles into an accretion disk and produces an Xray flare close to the Eddington limit of L{sub Edd} {approx} 10{sup 41}erg/s (Mbh/1000M{circle_dot}), typically lasting for a few months. The combination of a peculiar thermonuclear supernova together with an X-ray flare thus whistle-blows the existence of such moderate-mass black holes. The next generation of wide field space-based instruments should be able to detect such events.

  15. Ignition of thermonuclear microexplosions with antimatter

    SciTech Connect

    Shmatov, M.L.

    1994-10-01

    The use of antimatter for the indirect ignition of staged thermonuclear microexplosions is proposed. The space propulsion system based on this method may become economically acceptable earlier than that which uses only the energy of annihilation. 19 refs.

  16. Stability of Beta Limited Thermonuclear Burn.

    DTIC Science & Technology

    1980-01-28

    wunboeJ e burn stability of a thermonuclear reacting plasma Is examined under the assumption that a bum equilibrium exists due to the rapid Increase...of loss rate with plasma beta once a critical beta value is exceeded, it is found that perturbations about equilibrium generally result in a rapidly...exceeded, in order to establish a thermonuclear burn equilibrium , it is necessary that plasma losses increase sufficiently rapidly with temperature. In

  17. Perils of a Restless Planet

    NASA Astrophysics Data System (ADS)

    Zebrowski, Ernest, Jr.

    1999-05-01

    From epidemics and earthquakes to tornados and tidal waves, the overwhelming power of nature never ceases to instill humankind with both terror and awe. As natural disasters continue to claim human lives and leave destruction in their wake, Perils of a Restless Planet examines our attempts to understand and anticipate such phenomena. Now available in paperback, this highly acclaimed book draws on actual events from ancient to present times. Coverage focuses on basic scientific inquiry, technological innovation and, ultimately, public policy to provide a lucid and riveting look at the natural events that have shaped our view of natural disasters. While shedding light on the elusive quality of nature's intermittent tantrums and the limits scientific study and laboratory replication impose on our understanding of its mercurial ways, the author extrapolates from the history of science to suggest how we may someday learn to warn and protect the vulnerable populations on our small, tempestuous planet. Compelling and informative, this book will find readers both in and outside of the scientific community.

  18. Microtubules move the nucleus to quiescence.

    PubMed

    Laporte, Damien; Sagot, Isabelle

    2014-01-01

    The nucleus is a cellular compartment that hosts several macro-molecular machines displaying a highly complex spatial organization. This tight architectural orchestration determines not only DNA replication and repair but also regulates gene expression. In budding yeast microtubules play a key role in structuring the nucleus since they condition the Rabl arrangement in G1 and chromosome partitioning during mitosis through their attachment to centromeres via the kinetochore proteins. Recently, we have shown that upon quiescence entry, intranuclear microtubules emanating from the spindle pole body elongate to form a highly stable bundle that spans the entire nucleus. Here, we examine some molecular mechanisms that may underlie the formation of this structure. As the intranuclear microtubule bundle causes a profound re-organization of the yeast nucleus and is required for cell survival during quiescence, we discuss the possibility that the assembly of such a structure participates in quiescence establishment.

  19. Neutron Stars and Thermonuclear X-ray Bursts

    NASA Technical Reports Server (NTRS)

    Bhattacharyya, Supid

    2007-01-01

    This viewgraph presentation describes neutron stars and thermonuclear x ray bursts. The contents include: 1) Neutron Stars: why do we care?; 2) Thermonuclear Bursts: why do we care?; 3) Neutron Stars: Mass, Radius and Spin: a. Continuum Spectroscopy of Bursts b. Spectral Lines from Bursts c. Timing Properties of Bursts; 4) Neutron Star Atmosphere: Thermonuclear Flame Spreading; and 5) Future Prospects and Conclusions.

  20. The polonium-210 problem in thermonuclear reactor

    SciTech Connect

    Shchipakhin, O.L.; Borisov, N.B.; Churkin, S.L.

    1993-12-31

    Polonium 210 forms in the lithium-lead eutectic blanket of a thermonuclear reactor. On the basis of obtained experimental data some estimates have been calculated on the ITER blanket accident consequences. The LOCA type accident represents the failure of eutectic circuit in the process of transfusion of liquid eutectic from blanket to the tritium reprocessing plant.

  1. Laser Fusion - A New Thermonuclear Concept

    ERIC Educational Resources Information Center

    Cooper, Ralph S.

    1975-01-01

    Describes thermonuclear processes induced by interaction of a laser beam with the surface of a fuel pellet. An expanding plasma is formed which results in compression of the element. Laser and reactor technology are discussed. Pictures and diagrams are included. (GH)

  2. Plasma physics and controlled thermonuclear fusion

    SciTech Connect

    Krikorian, R. )

    1989-01-01

    This proceedings contains papers on plasma physics and controlled thermonuclear fusion. Included are the following topics: Plasma focus and Z-pinch, Review of mirror fusion research, Progress in studies of x-ray and ion-beam emission from plasma focus facilities.

  3. Thermonuclear model for high energy transients

    SciTech Connect

    Woosley, S.E.

    1982-01-01

    The thermonuclear model for x- and ..gamma..-ray bursts is discussed. Different regimes of nuclear burning are reviewed, each appropriate to a given range of (steady state) accretion rate. Accretion rates in the range 10/sup -14/ to 10/sup -8/ Msub solar y/sup -1/ all appear capable of producing x-ray transients of various durations and intervals. Modifications introduced by radiatively driven mass loss, the thermal inertia of the envelope, different burning mechanisms, and two-dimensional considerations are discussed as are difficulties encountered when the thermonuclear model is confronted with observations of rapidly recurrent bursts (less than or equal to 10 min), and super-Eddington luminosities and temperatures. Results from a numerical simulation of a combined hydrogen-helium runaway initiated at pycnonuclear density are presented for the first time. The thermonuclear model for ..gamma..-ray bursts is also reviewed and updated, particularly with regard to the breakdown of the steady state hypothesis employed in previous work. Solely on the basis of nuclear instability, ..gamma..-ray bursts of various types appear possible for a very broad variety of accretion rates (approx. 10/sup -17/ to approx. 10/sup -11/ Msub solar y/sup -1/) although other considerations may restrict this range. The thermonuclear model appears capable of yielding a great diversity of high energy transient phenomena for various accretion rates, magnetic field configurations, and neutron star envelope histories.

  4. Numerical analysis of thermonuclear detonation in dense plasma

    NASA Astrophysics Data System (ADS)

    Avronin, Y. N.; Bunatyan, A. A.; Gadzhiyev, A. D.; Mustafin, K. A.; Nurbakov, A. S.; Pisarev, V. N.; Feoktistov, L. P.; Frolov, V. D.; Shibarshov, L. I.

    1985-01-01

    The propagation of thermonuclear combustion from the region heated to thermonuclear temperatures by an external source to the remaining part of the target was investigated. The target was a tube of inert material (gold, lead, beryllium, etc.) filled with a deuterium-tritium mixture. It was determined analytically that thermonuclear combustion can propagate from a small portion of a nonspherical target to the remainder of the target and that a steady-state thermonuclear detonation wave can be formed. The role of various physical processes in thermonuclear detonation was investigated. Shock wave is the main mechanism underlying detonation propagation. The detonation rate and intensity of the thermonuclear reaction is influenced by the leakage of heat due to transvere heat conductivity. The critical diameter for thermonuclear detonation was determined approximately for a plasma filament encased in a housing with twice the density of the fuel.

  5. Merging white dwarfs and thermonuclear supernovae.

    PubMed

    van Kerkwijk, M H

    2013-06-13

    Thermonuclear supernovae result when interaction with a companion reignites nuclear fusion in a carbon-oxygen white dwarf, causing a thermonuclear runaway, a catastrophic gain in pressure and the disintegration of the whole white dwarf. It is usually thought that fusion is reignited in near-pycnonuclear conditions when the white dwarf approaches the Chandrasekhar mass. I briefly describe two long-standing problems faced by this scenario, and the suggestion that these supernovae instead result from mergers of carbon-oxygen white dwarfs, including those that produce sub-Chandrasekhar-mass remnants. I then turn to possible observational tests, in particular, those that test the absence or presence of electron captures during the burning.

  6. Profile of altered brain iron acquisition in restless legs syndrome.

    PubMed

    Connor, James R; Ponnuru, Padmavathi; Wang, Xin-Sheng; Patton, Stephanie M; Allen, Richard P; Earley, Christopher J

    2011-04-01

    Restless legs syndrome is a neurological disorder characterized by an urgency to move the legs during periods of rest. Data from a variety of sources provide a compelling argument that the amount of iron in the brain is lower in individuals with restless legs syndrome compared with neurologically normal individuals. Moreover, a significant percentage of patients with restless legs syndrome are responsive to intravenous iron therapy. The mechanism underlying the decreased iron concentrations in restless legs syndrome brains is unknown. We hypothesize that the source of the brain iron deficit is at the blood-brain interface. Thus we analysed the expression of iron management proteins in the epithelial cells of the choroid plexus and the brain microvasculature in post-mortem tissues. The choroid plexus, obtained at autopsy, from 18 neurologically normal controls and 14 individuals who had primary restless legs syndrome was subjected to histochemical staining for iron and immunostaining for iron management proteins. Iron and heavy chain ferritin staining was reduced in the epithelial cells of choroid plexus in restless legs syndrome. Divalent metal transporter, ferroportin, transferrin and its receptor were upregulated in the choroid plexus in restless legs syndrome. Microvessels were isolated from the motor cortex of 11 restless legs syndrome and 14 control brains obtained at autopsy and quantitative immunoblot analyses was performed. Expression of heavy chain ferritin, transferrin and its receptor in the microvessels from restless legs syndrome was significantly decreased compared with the controls but divalent metal protein 1, ferroportin, prohepcidin, mitochondrial ferritin and light-chain ferritin remained unchanged. The presence of an iron regulatory protein was demonstrated in the brain microvasculature and the activity of this protein is decreased in restless legs syndrome; a finding similar to our earlier report in neuromelanin cells from the substantia nigra

  7. Arteriolar niches maintain haematopoietic stem cell quiescence.

    PubMed

    Kunisaki, Yuya; Bruns, Ingmar; Scheiermann, Christoph; Ahmed, Jalal; Pinho, Sandra; Zhang, Dachuan; Mizoguchi, Toshihide; Wei, Qiaozhi; Lucas, Daniel; Ito, Keisuke; Mar, Jessica C; Bergman, Aviv; Frenette, Paul S

    2013-10-31

    Cell cycle quiescence is a critical feature contributing to haematopoietic stem cell (HSC) maintenance. Although various candidate stromal cells have been identified as potential HSC niches, the spatial localization of quiescent HSCs in the bone marrow remains unclear. Here, using a novel approach that combines whole-mount confocal immunofluorescence imaging techniques and computational modelling to analyse significant three-dimensional associations in the mouse bone marrow among vascular structures, stromal cells and HSCs, we show that quiescent HSCs associate specifically with small arterioles that are preferentially found in endosteal bone marrow. These arterioles are ensheathed exclusively by rare NG2 (also known as CSPG4)(+) pericytes, distinct from sinusoid-associated leptin receptor (LEPR)(+) cells. Pharmacological or genetic activation of the HSC cell cycle alters the distribution of HSCs from NG2(+) periarteriolar niches to LEPR(+) perisinusoidal niches. Conditional depletion of NG2(+) cells induces HSC cycling and reduces functional long-term repopulating HSCs in the bone marrow. These results thus indicate that arteriolar niches are indispensable for maintaining HSC quiescence.

  8. Oscillations During Thermonuclear X-ray Bursts

    NASA Technical Reports Server (NTRS)

    Strohmayer, Tod E.; White, Nicholas E. (Technical Monitor)

    2001-01-01

    High amplitude, nearly coherent X-ray brightness oscillations during thermonuclear X-ray bursts were discovered with the Rossi X-ray Timing Explorer (RXTE) in early 1996. Spectral and timing evidence strongly supports the conclusion that these oscillations are caused by rotational modulation of the burst emission and that they reveal the spin frequency of neutron stars in low mass X-ray binaries, a long sought goal of X-ray astronomy. Studies carried out over the past year have led to the discovery of burst oscillations in four new sources, bringing to ten the number with confirmed burst oscillations. I review the status of our knowledge of these oscillations and indicate how they can be used to probe the physics of neutron stars. For a few burst oscillation sources it has been proposed that the strongest and most ubiquitous frequency is actually the first overtone of the spin frequency and hence that two nearly antipodal hot spots are present on the neutron star. This inference has important implications for both the physics of thermonuclear burning as well as the mass - radius relation for neutron stars, so its confirmation is crucial. I discuss recent attempts to confirm this hypothesis for 4U 1636-53, the source for which a signal at the putative fundamental (290Hz) has, been claimed.

  9. Olanzapine-induced restless legs syndrome.

    PubMed

    Zhao, Mangsuo; Geng, Tongchao; Qiao, Liyan; Zhang, Mingjie; Shi, Jie; Huang, Fangjie; Lin, Xianzhong; Wang, Jing; Zuo, Huancong

    2014-09-01

    Only nine patients with olanzapine-induced restless legs syndrome (RLS) have been reported in the literature to our knowledge. We describe two patients with olanzapine-induced RLS treated at our hospital and review the nine reported patients. There were five women and six men aged between 28 and 62 years in the overall group. RLS symptoms emerged at olanzapine doses between 2.5 and 20mg. The symptoms improved in all patients when the dose was reduced and immediately disappeared when the medication was stopped. International Restless Legs Scale (IRLS) scores ranged from 10 to 35. Three patients had a family history of idiopathic RLS. Supplemental drugs were administered to control RLS symptoms in five patients. Ropinirole was effective in one patient, while two patients did not respond to the drug. Propoxyphene effectively relieved symptoms in one patient who did not respond to ropinirole or clonazepam. RLS symptoms did not recur following substitution of other antipsychotic drugs for olanzapine. In conclusion, olanzapine can induce RLS, particularly in patients with a family history of idiopathic RLS. More than half of the patients experienced severe to very severe symptoms. A dose-dependent relationship was observed between olanzapine and RLS symptoms. A gradual increase in dose may prevent olanzapine-induced RLS. The optimal treatment for olanzapine-induced RLS is discontinuation of olanzapine.

  10. The yeast genome undergoes significant topological reorganization in quiescence

    PubMed Central

    Rutledge, Mark T.; Russo, Mariano; Belton, Jon-Matthew; Dekker, Job; Broach, James R.

    2015-01-01

    We have examined the three-dimensional organization of the yeast genome during quiescence by a chromosome capture technique as a means of understanding how genome organization changes during development. For exponentially growing cells we observe high levels of inter-centromeric interaction but otherwise a predominance of intrachromosomal interactions over interchromosomal interactions, consistent with aggregation of centromeres at the spindle pole body and compartmentalization of individual chromosomes within the nucleoplasm. Three major changes occur in the organization of the quiescent cell genome. First, intrachromosomal associations increase at longer distances in quiescence as compared to growing cells. This suggests that chromosomes undergo condensation in quiescence, which we confirmed by microscopy by measurement of the intrachromosomal distances between two sites on one chromosome. This compaction in quiescence requires the condensin complex. Second, inter-centromeric interactions decrease, consistent with prior data indicating that centromeres disperse along an array of microtubules during quiescence. Third, inter-telomeric interactions significantly increase in quiescence, an observation also confirmed by direct measurement. Thus, survival during quiescence is associated with substantial topological reorganization of the genome. PMID:26202961

  11. Neutron Stars and Thermonuclear X-ray Bursts

    NASA Technical Reports Server (NTRS)

    Bhattacharyya, Sudip

    2007-01-01

    Studies of thermonuclear X-ray bursts can be very useful to constrain the spin rate, mass and radius of a neutron star approaching EOS model of high density cold matter in the neutron star cores. +k Extensive observation and analysis of the data from the rising portions of the bursts - modeling of burst oscillations and thermonuclear flame spreading. +k Theoretical study of thermonuclear flame spreading on the rapidly spinning neutron stars should be done considering all the main physical effects (including magnetic field, nuclear energy generation, Coriolis effect, strong gravity, etc.).

  12. Understanding Neutron Stars using Thermonuclear X-ray Bursts

    NASA Technical Reports Server (NTRS)

    Bhattacharyya, S.

    2007-01-01

    Studies of thermonuclear X-ray bursts can be very useful to constrain the spin rate, mass and radius of a neutron star = EOS model of high density cold matter in the neutron star cores. Extensive observation and analysis of the data from the rising portions of the bursts = modeling of burst oscillations and thermonuclear flame spreading. Theoretical study of thermonuclear flame spreading on the rapidly spinning neutron stars should be done considering all the main physical effects (including magnetic field, nuclear energy generation, Coriolis effect, strong gravity, etc.).

  13. Restless Legs Syndrome -- Self-Tests and Diagnosis

    MedlinePlus

    ... to locate sleep centers in your area. Search radius (in miles): 10 25 50 Share: Essentials in ... to locate sleep centers in your area. Search radius: Email Print Restless Legs Syndrome Overview & Facts Causes & ...

  14. Transient translational quiescence in primordial germ cells.

    PubMed

    Oulhen, Nathalie; Swartz, S Zachary; Laird, Jessica; Mascaro, Alexandra; Wessel, Gary

    2017-02-24

    Stem cells in animals often exhibit a slow cell cycle and/or low transcriptional activity referred to as quiescence. Here we report that the translational activity in the primordial germ cells (PGCs) of the sea urchin embryo (Strongylocentrotus purpuratus) is quiescent. We measured new protein synthesis with O-propargyl-puromycin, and L-homopropargylglycine, Click-iT technologies and determined that these cells synthesize protein at only 6% the level of their adjacent somatic cells. Knock-down of translation of the RNA-binding protein Nanos2 by morpholino anti-sense oligonucleotides, or knock-out of the Nanos2 gene by CRISPR/Cas9 resulted in a significant, but partial increase (47%) in general translation specifically in the PGCs. We found that the mRNA of the translation factor eEF1A is excluded from the PGCs in a Nanos2-dependent manner, a consequence of a Nanos/Pumilio response element (PRE) in its 3'UTR. In addition to eEF1A, the cytoplasmic pH of the PGCs appears to repress translation and simply increasing the pH also significantly restores translation selectively in the PGCs. We conclude that the PGCs of this sea urchin institute parallel pathways to quiesce translation thoroughly but transiently.

  15. Thermonuclear Reaction Rate Parameterization for Nuclear Astrophysics

    NASA Astrophysics Data System (ADS)

    Sharp, Jacob; Kozub, Raymond L.; Smith, Michael S.; Scott, Jason; Lingerfelt, Eric

    2004-10-01

    The knowledge of thermonuclear reaction rates is vital to simulate novae, supernovae, X-ray bursts, and other astrophysical events. To facilitate dissemination of this knowledge, a set of tools has been created for managing reaction rates, located at www.nucastrodata.org. One tool is a rate parameterizer, which provides a parameterization for nuclear reaction rate vs. temperature values in the most widely used functional form. Currently, the parameterizer uses the Levenberg-Marquardt method (LMM), which requires an initial estimate of the best-fit parameters. The initial estimate is currently provided randomly from a preselected pool. To improve the quality of fits, a new, active method of selecting parameters has been developed. The parameters of each set in the pool are altered for a few iterations to replicate the input data as closely as possible. Then, the set which most nearly matches the input data (based on chi squared) is used in the LMM as the initial estimate for the final fitting procedure. A description of the new, active algorithm and its performance will be presented. Supported by the U. S. Department of Energy.

  16. Bayesian Estimation of Thermonuclear Reaction Rates

    NASA Astrophysics Data System (ADS)

    Iliadis, C.; Anderson, K. S.; Coc, A.; Timmes, F. X.; Starrfield, S.

    2016-11-01

    The problem of estimating non-resonant astrophysical S-factors and thermonuclear reaction rates, based on measured nuclear cross sections, is of major interest for nuclear energy generation, neutrino physics, and element synthesis. Many different methods have been applied to this problem in the past, almost all of them based on traditional statistics. Bayesian methods, on the other hand, are now in widespread use in the physical sciences. In astronomy, for example, Bayesian statistics is applied to the observation of extrasolar planets, gravitational waves, and Type Ia supernovae. However, nuclear physics, in particular, has been slow to adopt Bayesian methods. We present astrophysical S-factors and reaction rates based on Bayesian statistics. We develop a framework that incorporates robust parameter estimation, systematic effects, and non-Gaussian uncertainties in a consistent manner. The method is applied to the reactions d(p,γ)3He, 3He(3He,2p)4He, and 3He(α,γ)7Be, important for deuterium burning, solar neutrinos, and Big Bang nucleosynthesis.

  17. Restless legs syndrome in patients on dialysis.

    PubMed

    Al-Jahdali, Hamdan H; Al-Qadhi, Waleed A; Khogeer, Haithm A; Al-Hejaili, Fayez F; Al-Ghamdi, Saeed M; Al Sayyari, Abdullah A

    2009-05-01

    Restless legs syndrome (RLS) is an extremely distressing problem experienced by patients on dialysis; the prevalence appears to be greater than in the general population, with a wide variation from 6.6% to 80%. The diagnosis of RLS is a clinical one, and its definition has been clarified and standardized by internationally recognized diagnostic criteria, published in 1995 by the International Restless Legs Syndrome Study Group (IRLSSG). This study was designed to find out the prevalence of RLS in Saudi patients with end-stage renal disease (ESRD) on maintenance dialysis. This is a cross sectional study carried out between May and Sept 2007 at two centers, King Abdulaziz Medical City-King Fahad National Guard Hospital (KAMC-KFNGH), Riyadh and King Faisal Specialist Hospital and Research Centre (KFHRC), Jeddah, Saudi Arabia. Data were gathered on 227 Saudi patients on chronic maintenance hemodialysis or chronic peritoneal dialysis. The prevalence of RLS was measured using IRLSSG's RLS Questionnaire (RLSQ). Potential risk factors for RLS including other sleep disorders, underlying cause of chronic renal failure, duration on dialysis, dialysis shift, biochemical tests and demographic data were also evaluated. The overall prevalence of RLS was 50.22% including 53.7% males and 46.3% females. Their mean age was 55.7 +/- 17.2 years and mean duration on dialysis 40.4 +/- 37.8 months. Significant predictors of RLS were history of diabetes mellitus (DM), coffee intake, afternoon dialysis, gender and type of dialysis (P= 0.03, 0.01, < 0.001, 0.05 and 0.009 respectively). Patients with RLS were found to be at increased risk of having insomnia and excessive daytime sleepiness (EDS) (P= < 0.001 and 0.001, respectively). Our study suggests that RLS is a very common problem in dialysis population and was significantly associated with other sleep disorders, particularly insomnia, and EDS. Optimal care of dialysis patient should include particular attention to the diagnosis and

  18. Pallasite paleomagnetism: Quiescence of a core dynamo

    NASA Astrophysics Data System (ADS)

    Nichols, Claire I. O.; Bryson, James F. J.; Herrero-Albillos, Julia; Kronast, Florian; Nimmo, Francis; Harrison, Richard J.

    2016-05-01

    Recent paleomagnetic studies of two Main Group pallasites, the Imilac and Esquel, have found evidence for a strong, late-stage magnetic field on the parent body. It has been hypothesized that this magnetic field was generated by a core dynamo, driven by compositional convection during core solidification. Cooling models suggest that the onset of core solidification occurred ∼200 Ma after planetary accretion. Prior to core solidification, a core dynamo may have been generated by thermal convection; however a thermal dynamo is predicted to be short-lived, with a duration of ∼10 Ma to ∼40 Ma after planetary accretion. These models predict, therefore, a period of quiescence between the thermally driven dynamo and the compositionally driven dynamo, when no core dynamo should be active. To test this hypothesis, we have measured the magnetic remanence recorded by the Marjalahti and Brenham pallasites, which based on cooling-rate data locked in any magnetic field signals present ∼95 Ma to ∼135 Ma after planetary accretion, before core solidification began. The cloudy zone, a region of nanoscale tetrataenite islands within a Fe-rich matrix was imaged using X-ray photoemission electron microscopy. The recovered distribution of magnetisation within the cloudy zone suggests that the Marjalahti and Brenham experienced a very weak magnetic field, which may have been induced by a crustal remanence, consistent with the predicted lack of an active core dynamo at this time. We show that the transition from a quiescent period to an active, compositionally driven dynamo has a distinctive paleomagnetic signature, which may be a crucial tool for constraining the time of core solidification on differentiated bodies, including Earth.

  19. Impact of Restless Legs Syndrome on Cardiovascular Autonomic Control

    PubMed Central

    Bertisch, Suzanne M.; Muresan, Cristen; Schoerning, Laura; Winkelman, John W.; Taylor, J. Andrew

    2016-01-01

    Study Objectives: To examine whether patients with restless legs syndrome demonstrate specific alterations in cardiovascular autonomic control. Methods: Patients with moderate-severe restless legs syndrome (n = 20, 80% female) and controls (n = 20) matched for age, sex, body mass index, and free of hypertension and cardiovascular disease were enrolled. We assessed cardiovagal baroreflex gain via the modified Oxford technique, sympathetically mediated vascular responses to isometric exercise to fatigue, bradycardiac response to Valsalva maneuver, and respiratory sinus arrhythmia during paced breathing. Standard electrocardiography, beat-by-beat arterial pressure, respiration, and popliteal blood flow velocity were recorded continuously. Results: Resting blood pressure and heart rate were similar between groups. However, baroreflex gain averaged 14.3 ± 1.4 msec/mm Hg in restless legs syndrome and was lower than in controls (22.6 ± 3.5 msec/mm Hg, P = 0.04). Hemodynamic responses to isometric exercise were similar between groups, though participants with restless legs syndrome had lower leg blood flow (P < 0.001), with greater leg vascular resistance (P < 0.0001), before and during isometric exercise. Respiratory sinus arrhythmia and Valsalva ratios were similar between groups. Neither baroreflex gain nor vascular resistance was correlated with sleep duration, sleep quality, or symptom duration. Conclusion: Patients with restless legs syndrome demonstrate compromised cardiovagal control, specific to the arterial baroreflex, with greater peripheral vascular resistance, potentially due to heightened sympathetic outflow. These autonomic alterations may directly relate to the higher prevalence of cardiovascular disease in restless legs syndrome. Citation: Bertisch SM, Muresan C, Schoerning L, Winkelman JW, Taylor JA. Impact of restless legs syndrome on cardiovascular autonomic control. SLEEP 2016;39(3):565–571. PMID:26564128

  20. Symmetrically converging plane thermonuclear burn waves

    NASA Astrophysics Data System (ADS)

    Charakhch'yan, A. A.; Khishchenko, K. V.

    2013-10-01

    Five variants of a one-dimensional problem on synchronous bilateral action of two identical drivers on opposite surfaces of a plane layer of DT fuel with the normal or five times greater initial density, where the solution includes two thermonuclear burn waves propagating to meet one another at the symmetry plane, are simulated. A laser pulse with total absorption of energy at the critical density (in two variants) and a proton bunch that provides for a nearly isochoric heating (in three variants) are considered as drivers. A wide-range equation of state for the fuel, electron and ion heat conduction, self-radiation of plasma and plasma heating by α-particles are taken into account. In spite of different ways of ignition, various models of α-particle heat, whether the burn wave remains slow or transforms into the detonation wave, and regardless of way of such a transformation, the final value of the burn-up factor depends essentially on the only parameter Hρ0, where H is the half-thickness of the layer and ρ0 is the initial fuel density. This factor is about 0.35 at Hρ0 ≈ 1 g cm-2 and about 0.7 at Hρ0 ≈ 5 g cm-2. The expansion stage of the flow (after reflecting the burn or detonation wave from the symmetry plane) gives the main contribution in forming the final values of the burn-up factor and the gain at Hρ0 ≈ 1 g cm-2 and increases them approximately two times at Hρ0 ≈ 5 g cm-2. In the case of the proton driver, the final value of the gain is about 200 at Hρ0 ≈ 1 g cm-2 and about 2000 at Hρ0 ≈ 5 g cm-2. In the case of the laser driver, the above values are four times less in conformity with the difference between the driver energies.

  1. Restless legs syndrome and pregnancy: A review

    PubMed Central

    Srivanitchapoom, Prachaya; Pandey, Sanjay; Hallett, Mark

    2014-01-01

    Restless legs syndrome (RLS) is a common sensorimotor neurological disorder that is diagnosed according to the revised criteria of the International RLS Study Group (IRLSSG). The pathophysiology of RLS is still unknown and its prevalence is influenced by ethnicity, age, and gender. RLS is divided into two types by etiology: primary or idiopathic and secondary. Primary RLS is strongly influenced by a genetic component while secondary RLS is caused by other associated conditions such as end-stage renal disease or peripheral neuropathy. Another common condition associated with RLS is pregnancy. The prevalence of RLS during pregnancy is two to three times higher than in the normal population and is influenced by the trimester and the number of parity. The main mechanisms that may contribute to the pathophysiology of RLS during pregnancy are hormonal changes and iron and folate status. Standard medications for treating RLS during pregnancy are not established. Most medications have been used according to the evidence from non-pregnant patients. Therefore, consideration of the medical treatment for treating RLS during pregnancy should be balanced between the benefit of relieving the symptoms and maternal and fetal risk. In general, the prognosis of RLS during pregnancy is good and symptoms are usually relieved after delivery. PMID:24768121

  2. Restless legs syndrome and pregnancy: a review.

    PubMed

    Srivanitchapoom, Prachaya; Pandey, Sanjay; Hallett, Mark

    2014-07-01

    Restless legs syndrome (RLS) is a common sensorimotor neurological disorder that is diagnosed according to the revised criteria of the International RLS Study Group (IRLSSG). The pathophysiology of RLS is still unknown and its prevalence is influenced by ethnicity, age, and gender. RLS is divided into two types by etiology: primary or idiopathic and secondary. Primary RLS is strongly influenced by a genetic component while secondary RLS is caused by other associated conditions such as end-stage renal disease or peripheral neuropathy. Another common condition associated with RLS is pregnancy. The prevalence of RLS during pregnancy is two to three times higher than in the normal population and is influenced by the trimester and the number of parity. The main mechanisms that may contribute to the pathophysiology of RLS during pregnancy are hormonal changes and iron and folate status. Standard medications for treating RLS during pregnancy are not established. Most medications have been used according to the evidence from non-pregnant patients. Therefore, consideration of the medical treatment for treating RLS during pregnancy should be balanced between the benefit of relieving the symptoms and maternal and fetal risk. In general, the prognosis of RLS during pregnancy is good and symptoms are usually relieved after delivery.

  3. Corticosterone predicts nocturnal restlessness in a long-distance migrant.

    PubMed

    Eikenaar, Cas; Klinner, Thomas; Stöwe, Mareike

    2014-07-01

    The decision made by migrating birds to stop refueling and to depart from stopover depends on cues from innate rhythms, intrinsic factors such as fuel reserves, and extrinsic factors such as weather conditions. The physiological mechanism behind this decision, however, is largely unexplored. The transition from refueling to flight involves an increase in both locomotion and energetic demands. Because, at baseline levels, corticosterone stimulates locomotion and is involved in the mobilization of energy, this hormone could encourage departure of migrants. We collected field data on baseline corticosterone, migratory restlessness, and actual departure in northern wheatears at stopover. Additionally, in refueling long-term captive conspecifics, we measured migratory restlessness while simultaneously collecting droppings to determine glucocorticoid metabolite (GCM) levels. We found that migratory restlessness at stopover was positively correlated with corticosterone level. Similarly, in refueling long-term captive birds, migratory restlessness was positively correlated with concurrently measured GCM levels in droppings. To our best knowledge, our study is the first to simultaneously measure a hormonal signal and migratory restlessness. In conclusion, our results are consistent with the hypothesis that, by increasing locomotor activity, baseline corticosterone is involved in the regulation of departure of migrants at stopover. Future studies could reveal how corticosterone is up-regulated in migrants that are ready to depart.

  4. Thermonuclear supernova light curves: Progenitors and cosmology

    NASA Astrophysics Data System (ADS)

    Rodney, Steven A.

    Thermonuclear Supernovae (TN SNe) are an extremely important tool in modern astronomy. In their role as cosmological distance probes, they have revealed the accelerated expansion of the universe and have begun to constrain the nature of the dark energy that may be driving that expansion. The next decade will see a succession of wide-field surveys producing thousands of TNSN detections each year. Traditional methods of SN analysis, rooted in time-intensive spectroscopic follow-up, will become completely impractical. To realize the potential of this coming tide of massive data sets, we will need to extract cosmographic parameters (redshift and luminosity distance) from SN photometry without any spectroscopic support. In this dissertation, I present the Supernova Ontology with Fuzzy Templates (SOFT) method, an innovative new approach to the analysis of SN light curves. SOFT uses the framework of fuzzy set theory to perform direct comparisons of SN candidates against template light curves, simultaneously producing both classifications and cosmological parameter estimates. The SOFT method allows us to shed new light on two rich archival data sets. I revisit the IfA Deep Survey and HST GOODS to extract new and improved measurements of the TNSN rate from z=0.2 out to z=1.6. Our new analysis shows a steady increase in the TNSN rate out to z˜1, and adds support for a decrease in the rate at z=1.5. Comparing these rate measurements to theoretical models, I conclude that the progenitor scenario most favored by the collective observational data is a single degenerate model, regulated by a strong wind from the accreting white dwarf. Using a compilation of SN light curves from five recent surveys, I demonstrate that SOFT is able to derive useful constraints on cosmological models from a data set with no spectroscopic information at all. Looking ahead to the near future, I find that photometric analysis of data sets containing 2,000 SNe will be able to improve our constraints on

  5. Do spherical tokamaks have a thermonuclear future?

    NASA Astrophysics Data System (ADS)

    Mirnov, S. V.

    2012-12-01

    the potential possibility of their use in thermonuclear research.

  6. NFATc1 balances quiescence and proliferation of skin stem cells

    PubMed Central

    Horsley, Valerie; Aliprantis, Antonios O.; Polak, Lisa; Glimcher, Laurie H.; Fuchs, Elaine

    2008-01-01

    Quiescent adult stem cells reside in specialized niches where they become activated to proliferate and differentiate during tissue homeostasis and injury. How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where it's expression is activated by BMP signaling upstream and it acts downstream to transcriptionally repress CDK4 and maintain stem cell quiescence. As stem cells become activated during hair growth, NFATc1 is downregulated, relieving CDK4 repression and activating proliferation. When calcineurin/NFATc1 signaling is suppressed, pharmacologically or via complete or conditional NFATc1 gene ablation, stem cells are activated prematurely, resulting in precocious follicular growth. Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-CDK4 circuitry in governing stem cell quiescence. PMID:18243104

  7. Methylene blue promotes quiescence of rat neural progenitor cells.

    PubMed

    Xie, Luokun; Choudhury, Gourav R; Wang, Jixian; Park, Yong; Liu, Ran; Yuan, Fang; Zhang, Chun-Li; Yorio, Thomas; Jin, Kunlin; Yang, Shao-Hua

    2014-01-01

    Neural stem cell-based treatment holds a new therapeutic opportunity for neurodegenerative disorders. Here, we investigated the effect of methylene blue on proliferation and differentiation of rat neural progenitor cells (NPCs) both in vitro and in vivo. We found that methylene blue inhibited proliferation and promoted quiescence of NPCs in vitro without affecting committed neuronal differentiation. Consistently, intracerebroventricular infusion of methylene blue significantly inhibited NPC proliferation at the subventricular zone (SVZ). Methylene blue inhibited mTOR signaling along with down-regulation of cyclins in NPCs in vitro and in vivo. In summary, our study indicates that methylene blue may delay NPC senescence through enhancing NPCs quiescence.

  8. Thermonuclear supernovae: simulations of the deflagration stage and their implications.

    PubMed

    Gamezo, Vadim N; Khokhlov, Alexei M; Oran, Elaine S; Chtchelkanova, Almadena Y; Rosenberg, Robert O

    2003-01-03

    Large-scale, three-dimensional numerical simulations of the deflagration stage of a thermonuclear supernova explosion show the formation and evolution of a highly convoluted turbulent flame in the gravitational field of an expanding carbon-oxygen white dwarf. The flame dynamics are dominated by the gravity-induced Rayleigh-Taylor instability that controls the burning rate. The thermonuclear deflagration releases enough energy to produce a healthy explosion. The turbulent flame, however, leaves large amounts of unburned and partially burned material near the star center, whereas observations that imply these materials are present only in outer layers. This disagreement could be resolved if the deflagration triggers a detonation.

  9. Patterns of significant seismic quiescence on the Mexican Pacific coast

    NASA Astrophysics Data System (ADS)

    Muñoz-Diosdado, A.; Rudolf-Navarro, A. H.; Angulo-Brown, F.; Barrera-Ferrer, A. G.

    Many authors have proposed that the study of seismicity rates is an appropriate technique for evaluating how close a seismic gap may be to rupture. We designed an algorithm for identification of patterns of significant seismic quiescence by using the definition of seismic quiescence proposed by Schreider (1990). This algorithm shows the area of quiescence where an earthquake of great magnitude may probably occur. We have applied our algorithm to the earthquake catalog on the Mexican Pacific coast located between 14 and 21 degrees of North latitude and 94 and 106 degrees West longitude; with depths less than or equal to 60 km and magnitude greater than or equal to 4.3, which occurred from January, 1965 until December, 2014. We have found significant patterns of seismic quietude before the earthquakes of Oaxaca (November 1978, Mw = 7.8), Petatlán (March 1979, Mw = 7.6), Michoacán (September 1985, Mw = 8.0, and Mw = 7.6) and Colima (October 1995, Mw = 8.0). Fortunately, in this century earthquakes of great magnitude have not occurred in Mexico. However, we have identified well-defined seismic quiescences in the Guerrero seismic-gap, which are apparently correlated with the occurrence of silent earthquakes in 2002, 2006 and 2010 recently discovered by GPS technology.

  10. Quantitative Mapping of Precursory Seismic Quiescence Before Large Aftershocks

    NASA Astrophysics Data System (ADS)

    Neukomm, S.; Wiemer, S.; Giardini, D.

    2002-12-01

    A relative decrease of aftershock activity before the occurrence of large aftershocks to M6+ mainshocks is one of only few earthquake precursors accepted for the IASPEI preliminary list of significant earthquake precursors. If one considers earthquake rate to be dependent on stressing rate, aftershocks sequences offer in fact an ideal environment to detect precursory quiescence before large earthquakes: The numerous aftershocks allow a much higher spatial and temporal resolution of transients in seismicity than possible with the average background rate of micro-earthquakes. Past studies of precursory quiescence before larger aftershocks, however, have largely been based on bulk value. The aim of this study is to map the temporal and spatial variability of activity rate within several rich aftershock sequences, and, possibly, exploit the results for improving real time probabilistic aftershock hazard assessment. We introduce a new algorithm based on fitting the modified Omori law to the aftershock sequences. At arbitrarily chosen grid points, the Omori parameters of the sub-samples containing all aftershock within 5 or 10 km of the node are estimated at time t. We calculate the number of aftershocks N +/- dN in the time interval t + dt using the relevant four Omori parameters (p, c and k) parameters and their corresponding standard deviations estimated using a bootstrap analysis. The difference between the forecasted and the observed number of aftershocks, normalized by the standard deviation of the forecast, is our estimator of rate change. The algorithm is tested on synthetic aftershock sequences containing artificial quiescences in order to calibrate the free parameters for optimal detection of precursory quiescence. We then perform our spatial and temporal mapping for several prominent Californian and Japanese aftershock sequences (Landers, Hector Mine, Northridge, Loma Prieta, Kobe, Western Tottori and Hokkaido). Preliminary results suggest that we cannot

  11. Thermonuclear Fusion: An Energy Source for the Future

    ERIC Educational Resources Information Center

    Drummond, William E.

    1973-01-01

    Discusses current research in thermonuclear fusion with particular emphasis on the problem of confining hot plasma. Recent experiments indicate that magnetic bottles called tokamaks may achieve the necessary confinement times, and this break-through has given renewed optimism to the feasibility of commercial fusion power by the turn of the…

  12. [Restless legs syndrome and diabetes mellitus: an accidental association?].

    PubMed

    Greco, Domenico

    2011-05-01

    Although limited in number, several studies have documented an increased prevalence of Restless Legs Syndrome (RLS) in type 2 diabetes. Polyneuropathy only partially explains the relation between the two disorders. This association could be due to the effects of a prolonged sleep loss: in increasing the probability of developing insulin-resistance and metabolic disturbances.

  13. Immune quiescence: a model of protection against HIV infection.

    PubMed

    Card, Catherine M; Ball, Terry Blake; Fowke, Keith R

    2013-11-20

    Aberrant immune activation is a strong correlate of HIV disease progression, but little is known about how immune activation alters susceptibility to HIV infection. Susceptibility to HIV infection varies between individuals, but the immunological determinants of HIV transmission are not well understood. Here, we present evidence from studies of HIV transmission in the context of clinical trials and HIV-exposed seronegative (HESN) cohorts that implicates elevated immune activation as a risk factor for acquiring HIV. We propose a model of protection from infection based on a phenotype of low baseline immune activation referred to as immune quiescence. Immune quiescence is evidenced by reduced expression of T cell activation markers, low levels of generalized gene transcription and low levels of proinflammatory cytokine and chemokine production in the periphery and genital mucosa of HESN. Since HIV preferentially replicates in activated CD4+ T cells, immune quiescence may protect against infection by limiting HIV target cell availability. Although the determinants of immune quiescence are unclear, several potential factors have been identified that may be involved in driving this phenotype. HESN were shown to have elevated proportions of regulatory T cells (Tregs), which are known to suppress T cell activation. Likewise, proteins involved in controlling inflammation in the genital tract have been found to be elevated in HESN. Furthermore, expression of interferon regulatory factor 1 (IRF-1) is reduced in HESN as a consequence of genetic polymorphisms and differential epigenetic regulation. Since IRF-1 is an important regulator of immune responses, it may play a role in maintaining immune quiescence. Based on this model, we propose a novel avenue for HIV prevention targeted based on reducing host mucosal immune activation.

  14. Restless Legs Syndrome in a Nigerian Elderly Population

    PubMed Central

    Fawale, Michael B.; Ismaila, Isiaka Alani; Mustapha, Adekunle F.; Komolafe, Morenikeji A.; Adedeji, Tewogbade A.

    2016-01-01

    Study Objectives: The prevalence of restless legs syndrome (RLS) is highest in the elderly in Caucasian populations; the prevalence of RLS in elderly Africans is not known. This study aimed at determining the frequency and associations of RLS in a Nigerian elderly population. Methods: The study population comprised of 633 consecutive elderly individuals aged 65–105 years attending the general outpatient clinic of the State Hospital, Ilesa, for minor complaints and routine check-up. The diagnosis of RLS was made using the 2003 minimal criteria of the International Restless Legs Syndrome Study Group. Relevant sociodemographic and clinical data, including sleep duration, were also obtained. Results: Restless legs syndrome was found in 3.5% of the study population with a male-female ratio of 2:1. There was no significant age (p = 0.427) or gender (p = 0.178) influence on the prevalence of RLS except in the 75- to 84-year age group where there was significant male preponderance (p = 0.044). A strong independent association between RLS and sleep duration (OR, 3.229; 95% CI, 1.283–8.486; p = 0.013) and past history of head injury (OR, 4.691; 95% CI, 1.750–12.577; p = 0.002) was found. Conclusions: Our finding support previous reports of a possible lower prevalence of RLS in Africans. Restless legs syndrome independently increases the odds of habitual sleep curtailment in elderly individuals. Head injury may be a risk factor for future RLS; this requires further investigation as indirect evidence for a possible link between RLS and traumatic brain injury exists. Citation: Fawale MB, Ismaila IA, Mustapha AF, Komolafe MA, Adedeji TA. Restless legs syndrome in a Nigerian elderly population. J Clin Sleep Med 2016;12(7):965–972. PMID:27070251

  15. Ropinirole: new indication. Restless legs: disproportionate adverse effects.

    PubMed

    2006-10-01

    (1) The restless legs syndrome consists of unpleasant sensory and motor symptoms of varying intensity in the lower limbs. Symptoms occur at rest, seated or lying down, are more intense in the evening and at night, and are relieved by moving the limb. This syndrome does not cause serious physical complications. When sleep disturbances occur, non drug methods should be tried first. (2) Ropinirole is a dopaminergic agonist initially marketed for the treatment of Parkinson's disease. It is the first drug to be approved for restless legs syndrome in France. (3) Three double-blind randomised placebo-controlled trials with similar designs showed minimal differences on a composite rating scale. After 12 weeks of treatment, ropinirole led to an improvement of about 3 points on a 40-point scale compared with placebo. (4) A 12-week double-blind randomised controlled trial and including patients who had "responded" to ropinirole showed a lower relapse rate in the group that continued to use ropinirole (32.6%) instead of switching to placebo (57.8%). However, we do not know if this was because of continued drug efficacy or a rebound effect in the placebo group. (5) The adverse effects of ropinirole in patients with restless legs syndrome had already been observed in the treatment of Parkinson's disease, and included nausea, vomiting, drowsiness, a sudden urge to sleep, syncope, hypotension, and hallucinations. (6) An increase in the severity of restless legs symptoms, typically seen with levodopa, was not evaluated in clinical trials of ropinirole. Some cases have nevertheless been reported. They describe the appearance of symptoms increasingly early in the evening, then in the afternoon, or as a rebound effect in the morning or the latter part of the night. Their intensity increases and can affect other parts of the body. (7) In practice, ropinirole has a negative risk-benefit balance in restless legs syndrome, which is a minor health disorder.

  16. Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch.

    PubMed

    Seidel, Hannah S; Kimble, Judith

    2015-11-09

    Many types of adult stem cells exist in a state of cell-cycle quiescence, yet it has remained unclear whether quiescence plays a role in maintaining the stem cell fate. Here we establish the adult germline of Caenorhabditis elegans as a model for facultative stem cell quiescence. We find that mitotically dividing germ cells--including germline stem cells--become quiescent in the absence of food. This quiescence is characterized by a slowing of S phase, a block to M-phase entry, and the ability to re-enter M phase rapidly in response to re-feeding. Further, we demonstrate that cell-cycle quiescence alters the genetic requirements for stem cell maintenance: The signaling pathway required for stem cell maintenance under fed conditions--GLP-1/Notch signaling--becomes dispensable under conditions of quiescence. Thus, cell-cycle quiescence can itself maintain stem cells, independent of the signaling pathway otherwise essential for such maintenance.

  17. Dopa responsive burning mouth syndrome: restless mouth syndrome or oral variant of restless legs syndrome?

    PubMed

    Prakash, Sanjay; Ahuja, Sunil; Rathod, Chirag

    2012-09-15

    Burning mouth syndrome (BMS) is an oral dysesthesia presenting as a burning sensation of the tongue and other oral and perioral mucosae. A painful symptomatology in different bodily regions (extraoral) may also be a common feature in patient with BMS. The management of BMS is challenging and there is no clear guideline for the management of idiopathic BMS. Herein, we describe a group of patients (5 patients) in whom symptoms of BMS responded to levodopa. In parallel, four patients fulfilled the criteria for restless legs syndrome (RLS). Family history of RLS was positive in two patients. We reviewed the literature and noted a marked overlap between BMS and RLS. Overlaps were noted in epidemiological profiles, pattern of clinical features and even in neurophysiological observations (alterations in the striatal dopaminergic system). We suggest that a subset of patients with BMS may be a phenotypic variant of RLS and a trial of dopaminergic drugs should be given in patients with BMS who has a history suggestive of RLS or in a patient who do not show a response to usual therapies for BMS.

  18. Thermonuclear Burning as a Probe of Neutron Star

    NASA Technical Reports Server (NTRS)

    Strohmayer, Tod

    2008-01-01

    Thermonuclear fusion is a fundamental process taking place in the matter transferred onto neutron stars in accreting binary systems. The heat deposited by nuclear reactions becomes readily visible in the X-ray band when the burning is either unstable or marginally stable, and results in the rich phenomenology of X-ray bursts, superbursts, and mHz quasiperiodic oscillations. Fast X-ray timing observations with NASA's Rossi X-ray Timing Explorer (RXTE) over the past decade have revealed a wealth of new phenomena associated with thermonuclear burning on neutron stars, including the discovery of nuclear powered pulsations during X-ray bursts and superbursts. I will briefly review our current observational and theoretical understanding of these new phenomena, with an emphasis on recent findings, and discuss what they are telling us about the structure of neutron stars.

  19. Strong plasma screening in thermonuclear reactions: Electron drop model

    NASA Astrophysics Data System (ADS)

    Kravchuk, P. A.; Yakovlev, D. G.

    2014-01-01

    We analyze enhancement of thermonuclear fusion reactions due to strong plasma screening in dense matter using a simple electron drop model. In the model we assume fusion in a potential that is screened by an effective electron cloud around colliding nuclei (extended Salpeter ion-sphere model). We calculate the mean-field screened Coulomb potentials for atomic nuclei with equal and nonequal charges, appropriate astrophysical S factors, and enhancement factors of reaction rates. As a byproduct, we study the analytic behavior of the screening potential at small separations between the reactants. In this model, astrophysical S factors depend not only on nuclear physics but on plasma screening as well. The enhancement factors are in good agreement with calculations by other methods. This allows us to formulate a combined, pure analytic model of strong plasma screening in thermonuclear reactions. The results can be useful for simulating nuclear burning in white dwarfs and neutron stars.

  20. Atypical Thermonuclear Supernovae from Tidally Crushed White Dwarfs

    SciTech Connect

    Rosswog, S.; Ramirez-Ruiz, E.; Hix, William Raphael

    2008-01-01

    Suggestive evidence has accumulated that intermediate mass black holes (IMBHs) exist in some globular clusters. Some stars will inevitably wander sufficiently close to the hole to suffer a tidal disruption. IMBHs can disrupt not only solar-type stars but also compact white dwarf stars. We investigate the fate of white dwarfs that approach the hole close enough to be disrupted and compressed to such an extent that explosive nuclear burning is triggered. Based on a precise modeling of the gas dynamics together with the nuclear reactions, it is argued that thermonuclear ignition is a natural outcome for white dwarfs of all masses passing well within the tidal radius. A good fraction of the star is accreted, yielding high luminosities that persist for up to a year. A peculiar, underluminous thermonuclear explosion accompanied by a soft X-ray transient signal would, if detected, be a compelling testimony for the presence of an IMBH.

  1. Shock ignition of thermonuclear fuel with high areal density.

    PubMed

    Betti, R; Zhou, C D; Anderson, K S; Perkins, L J; Theobald, W; Solodov, A A

    2007-04-13

    A novel method by C. Zhou and R. Betti [Bull. Am. Phys. Soc. 50, 140 (2005)] to assemble and ignite thermonuclear fuel is presented. Massive cryogenic shells are first imploded by direct laser light with a low implosion velocity and on a low adiabat leading to fuel assemblies with large areal densities. The assembled fuel is ignited from a central hot spot heated by the collision of a spherically convergent ignitor shock and the return shock. The resulting fuel assembly features a hot-spot pressure greater than the surrounding dense fuel pressure. Such a nonisobaric assembly requires a lower energy threshold for ignition than the conventional isobaric one. The ignitor shock can be launched by a spike in the laser power or by particle beams. The thermonuclear gain can be significantly larger than in conventional isobaric ignition for equal driver energy.

  2. Method of achieving the controlled release of thermonuclear energy

    DOEpatents

    Brueckner, Keith A.

    1986-01-01

    A method of achieving the controlled release of thermonuclear energy by illuminating a minute, solid density, hollow shell of a mixture of material such as deuterium and tritium with a high intensity, uniformly converging laser wave to effect an extremely rapid build-up of energy in inwardly traveling shock waves to implode the shell creating thermonuclear conditions causing a reaction of deuterons and tritons and a resultant high energy thermonuclear burn. Utilizing the resulting energy as a thermal source and to breed tritium or plutonium. The invention also contemplates a laser source wherein the flux level is increased with time to reduce the initial shock heating of fuel and provide maximum compression after implosion; and, in addition, computations and an equation are provided to enable the selection of a design having a high degree of stability and a dependable fusion performance by establishing a proper relationship between the laser energy input and the size and character of the selected material for the fusion capsule.

  3. [A case of Parkinson's disease following restless genial sensation].

    PubMed

    Sawamura, Masanori; Toma, Keiichiro; Unai, Yuki; Sekiya, Tomoko; Nishinaka, Kazuhito; Udaka, Fukashi

    2015-01-01

    A 62-year-old woman experienced uncomfortable genial sensation in 2010. Her uncomfortable sensation was exacerbated during rest at night and improved by walking. She exhibited short-stepped gait with postural disturbance and was diagnosed as suffering from Parkinson's disease (PD) in 2013. Administration of clonazepam and pramipexisole improved her uncomfortable genial sensation. In persistent genital arousal disorder (PGAD)/restless genial syndrome (RGS), abnormal genital sensation occurred without sexual desire, which was relieved by clonazepam administration. PGAD/RGS often coexists with restless legs syndrome (RLS). PGAD/RGS and RLS share common characteristics. This is the first case report of PD following PGAD/RGS, suggesting similar underlying mechanisms between PGAD/RGS and RLS associated with PD.

  4. Possibilities of applications of fiber Bragg gratings for thermonuclear fusion technology

    NASA Astrophysics Data System (ADS)

    Gasior, P.

    2016-09-01

    The research on harnessing thermonuclear fusion is considered to be important for reaching global energetic safety as the future thermonuclear fusion reactors offer an inexhaustible and CO2 emission free source of electric power. The development of thermonuclear fusion reactors is a great interdisciplinary effort which needs participation of scientists dealing with many fields of physics and engineering. Due to the experimental character of the works (the best example is the effort for the development of ITER - International Thermonuclear Experimental Reactor) its crucial part is in the design and application of diagnostics operating in harsh thermonuclear environments. Fiber optics and especially fiber Bragg gratings are components which can operate feasibly in both irradiation and electromagnetic interference conditions. This paper is to give a prospect of application of fiber Bragg grating sensors in devices aimed on the research in the thermonuclear fusion field.

  5. Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration.

    PubMed

    Rumman, Mohammad; Dhawan, Jyotsna; Kassem, Moustapha

    2015-10-01

    Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.

  6. Thermonuclear milestones: (2) Beginnings of the Soviet H-bomb program

    SciTech Connect

    Goncharov, G.A.

    1996-11-01

    Early Soviet theoretical work on thermonuclear ignition was adied by espionage, but many important ideas were conceived and developed independently {copyright} {ital 1996 American Institute of Physics.}

  7. Patterns of significant seismic quiescence in the Pacific Mexican coast

    NASA Astrophysics Data System (ADS)

    Muñoz-Diosdado, Alejandro; Rudolf-Navarro, Adolfo; Barrera-Ferrer, Amilcar; Angulo-Brown, Fernando

    2014-05-01

    Mexico is one of the countries with higher seismicity. During the 20th century, 8% of all the earthquakes in the world of magnitude greater than or equal to 7.0 have taken place in Mexico. On average, an earthquake of magnitude greater than or equal to 7.0 occurred in Mexico every two and a half years. Great earthquakes in Mexico have their epicenters in the Pacific Coast in which some seismic gaps have been identified; for example, there is a mature gap in the Guerrero State Coast, which potentially can produce an earthquake of magnitude 8.2. With the purpose of making some prognosis, some researchers study the statistical behavior of certain physical parameters that could be related with the process of accumulation of stress in the Earth crust. Other researchers study seismic catalogs trying to find seismicity patterns that are manifested before the occurrence of great earthquakes. Many authors have proposed that the study of seismicity rates is an appropriate technique for evaluating how close a seismic gap may be to rupture. We designed an algorithm for identification of patterns of significant seismic quiescence by using the definition of seismic quiescence proposed by Schreider (1990). This algorithm shows the area of quiescence where an earthquake of great magnitude will probably occur. We apply our algorithm to the earthquake catalogue of the Mexican Pacific coast located between 14 and 21 degrees of North latitude and 94 and 106 degrees West longitude; with depths less or equal to 60 km and magnitude greater or equal to 4.2, which occurred from September, 1965 until December, 2014. We have found significant patterns of seismic quietude before the earthquakes of Oaxaca (November 1978, Mw = 7.8), Petatlán (March 1979, Mw = 7.6), Michoacán (September 1985, Mw = 8.0, and Mw = 7.6) and Colima (October 1995, Mw = 8.0). Fortunately, in this century have not occurred earthquakes of great magnitude in Mexico, however, we have identified well-defined seismic

  8. Thermonuclear runaways in thick hydrogen rich envelopes of neutron stars

    NASA Technical Reports Server (NTRS)

    Starrfield, S. G.; Kenyon, S.; Truran, J. W.; Sparks, W. M.

    1981-01-01

    A Lagrangian, fully implicit, one dimensional hydrodynamic computer code was used to evolve thermonuclear runaways in the accreted hydrogen rich envelopes of 1.0 Msub solar neutron stars with radii of 10 km and 20 km. Simulations produce outbursts which last from about 750 seconds to about one week. Peak effective temeratures and luninosities were 26 million K and 80 thousand Lsub solar for the 10 km study and 5.3 millison and 600 Lsub solar for the 20 km study. Hydrodynamic expansion on the 10 km neutron star produced a precursor lasting about one ten thousandth seconds.

  9. Restless legs syndrome and its associated risk factors in Parkinson's disease.

    PubMed

    Azmin, Shahrul; Khairul Anuar, Abdul Manaf; Nafisah, Wan Yahya; Tan, Hui Jan; Raymond, Azman Ali; Hanita, Othman; Shah, Shamsul Azhar; Norlinah, Mohamed Ibrahim

    2013-01-01

    Introduction. Restless legs syndrome has been shown to negatively impact the quality of life of patients. Studies have shown an association between restless legs syndrome and Parkinson's disease. We attempted to investigate the prevalence of restless legs syndrome in Parkinson's disease patients and to identify associated risk factors. Method. This was a cross-sectional study among patients with idiopathic Parkinson's disease. Exclusion criterion was a Mini Mental State Examination score of less than 21/30. The International Restless Legs Syndrome Study Group criterion was used to identify patients with restless legs syndrome. Results. A total of 113 patients were recruited. The prevalence rate of restless legs syndrome in our cohort was 9.7% and was significantly associated with a younger onset of Parkinson's disease (P = 0.023), male gender (P = 0.045), higher Mini Mental State Examination score (P = 0.004), and less advanced Hoehn & Yahr stage (P = 0.014). Conclusion. The prevalence rate of restless legs syndrome in our Parkinson's disease population is in keeping with other studies published worldwide. The significance of the association between a younger onset of Parkinson's disease and restless legs syndrome needs to be further investigated.

  10. A restless abdomen and propriospinal myoclonus like at sleep onset: an unusual overlap syndrome

    PubMed Central

    Baiardi, Simone; La Morgia, Chiara; Mondini, Susanna; Cirignotta, Fabio

    2015-01-01

    We report for the first time the association between restless abdomen, a phenotypic variant of restless legs syndrome in which symptoms are limited to the abdomen, and propriospinal myoclonus at sleep onset causing severe insomnia. The treatment with a low-dosage of dopaminergic drug (pramipexole) induced the immediate disappearance of both symptoms, which was documented by video-polysomnography. PMID:25820108

  11. Diagnosis and management of restless legs syndrome in children

    PubMed Central

    Simakajornboon, Narong; Kheirandish-Gozal, Leila; Gozal, David

    2010-01-01

    Summary Recent published evidence suggests that restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) are common condition in children and adolescents. It is likely that if left untreated, RLS and PLMD may lead to adverse cardiovascular and neurocognitive consequences. However, the diagnosis of RLS and PLMD in children is challenging, particularly because children are relatively unable to describe typical RLS symptoms. The International Restless Legs Study Group has recently published consensus criteria for the diagnosis of RLS and PLMD in children. In addition to clinical description of RLS symptoms, supportive evidence including the presence of clinical sleep disturbances, documented periodic limb movements in sleep from overnight sleep study and family history of restless legs syndrome may be required. Few if any controlled studies have addressed the management of RLS and PLMD, which may involve both non-pharmacologic and pharmacologic approaches. In this context, the importance of avoidance of aggravating factors and good sleep hygiene cannot be overemphasized. Children with evidence of low-iron storage, i.e., low-serum ferritin and/ or iron levels may likely benefit from iron therapy. While there is overall limited experience regarding the use of dopaminergic agents in children with RLS and PLMD, published reports suggesting efficacy of compounds such as levodopa, ropinirole, pramipexole and pergolide have emerged. Other medications including benzodiazepine, anti-convulsants, alpha-adrenergic and opioid medications have not been adequately studied in children. Children with RLS and PLMD should have regular follow-up visits to evaluate clinical improvement and to monitor adverse effects from the selected therapy. Based on aforementioned findings, it is clear that a substantial research effort is needed to evaluate the pathophysiology, PMID:19186083

  12. The classification of magnetohydrodynamic regimes of thermonuclear combustion

    SciTech Connect

    Remming, Ian S.; Khokhlov, Alexei M.

    2014-10-10

    Physical properties of magnetohydrodynamic (MHD) reaction fronts are studied as functions of the thermodynamic conditions, and the strength and orientation of the magnetic field in the unburned matter through which the fronts propagate. We determine the conditions for the existence of the various types of MHD reaction fronts and the character of the changes in physical quantities across these reaction fronts. The analysis is carried out in general for a perfect gas equation of state and a constant energy release, and then extended to thermonuclear reaction fronts in degenerate carbon-oxygen mixtures and degenerate helium in conditions typical of Type Ia supernova explosions. We find that as unburned matter enters perpendicular to a reaction front, the release of energy through burning generates shear velocity in the reacting gas that, depending on the type of reaction front, strengthens or weakens the magnetic field. In addition, we find that the steady-state propagation of a reaction front is impossible for certain ranges of magnetic field direction. Our results provide insight into the phenomena of MHD thermonuclear combustion that is relevant to the interpretation of future simulations of SN Ia explosions that have magnetic fields systematically incorporated.

  13. Thermonuclear Supernova Explosions From Hybrid White Dwarf Progenitors

    NASA Astrophysics Data System (ADS)

    Willcox, Donald E.; Townsley, Dean; Calder, Alan; Denissenkov, Pavel; Herwig, Falk

    2016-01-01

    Motivated by recent results in stellar evolution in which convective boundary mixing in SAGB stars can give rise to hybrid white dwarf (WD) stars with a C-O core inside an O-Ne shell, we simulate thermonuclear (Type Ia) supernovae from these hybrid progenitors. We use the FLASH code to perform multidimensional simulations in the deflagration to detonation transition (DDT) explosion paradigm from progenitor models produced with the MESA stellar evolution code that include the thermal energetics of the Urca process. We performed a suite of DDT simulations over a range of ignition conditions and compare to previous results from a suite of C-O white dwarfs. Despite significant variability within each suite, distinguishing trends are apparent in their Ni-56 yields and the kinetic properties of their ejecta. We comment on the feasibility of these hybrid WD explosions as the source of some classes of observed subluminous events. This research was supported in part by the U.S. Department of Energy under grant DE-FG02-87ER40317 and by resources at the Institute for Advanced Computational Science at Stony Brook University. The software used in this work was in part developed by the DOE-supported ASC/Alliances Center for Astrophysical Thermonuclear Flashes at the University of Chicago.

  14. Cellular quiescence in mammary stem cells and breast tumor stem cells: got testable hypotheses?

    PubMed

    Harmes, David C; DiRenzo, James

    2009-03-01

    Cellular quiescence is a state of reversible cell cycle arrest and has more recently been shown to be a blockade to differentiation and to correlate with resistance to cancer chemotherapeutics and other xenobiotics; features that are common to adult stem cells and possibly tumor stem cells. The biphasic kinetics of mammary regeneration, coupled to its cyclic endocrine control suggest that mammary stem cells most likely divide during a narrow window of the regenerative cycle and return to a state of quiescence. This would enable them to retain their proliferative capacity, resist differentiation signals and preserve their prolonged life span. There is accumulating evidence that mammary stem cells and other adult stem cells utilize quiescence for this purpose, however the degree to which tumor stem cells do so is largely unknown. The retained proliferative capacity of mammary stem cells likely enables them to accumulate and harbor mutations that lead to breast cancer initiation. However it is currently unclear if these causative lesions lead to defective or deranged quiescence in mammary stem cells. Evidence of such effects could potentially lead to the development of diagnostic systems that monitor mammary stem cell quiescence or activation. Such systems may be useful for the evaluation of patients who are at significant risk of breast cancer. Additionally quiescence has been postulated to contribute to therapeutic resistance and tumor recurrence. This review aims to evaluate what is known about the mechanisms governing cellular quiescence and the role of tumor stem cell quiescence in breast cancer recurrence.

  15. INSTRUMENTS AND METHODS OF INVESTIGATION Nanostructures in controlled thermonuclear fusion devices

    NASA Astrophysics Data System (ADS)

    Krauz, V. I.; Martynenko, Yurii V.; Svechnikov, N. Yu; Smirnov, Valentin P.; Stankevich, V. G.; Khimchenko, L. N.

    2011-01-01

    It is shown that the presence of nano-sized and nano-structured erosion products not only affects the operation of thermonuclear devices but also, to a large extent, determines the safety and economy of future thermonuclear reactors. The formation mechanisms and the characteristics and properties of deposited films and nano-sized dust that form in tokamaks are reviewed.

  16. Aedes aegypti pharate 1st instar quiescence affects larval fitness and metal tolerance.

    PubMed

    Perez, Mario H; Noriega, Fernando G

    2012-06-01

    The eggs of the mosquito Aedes aegypti possess the ability to undergo an extended quiescence hosting a fully developed 1st instar larvae within the chorion. As a result of this life history trait pharate larvae can withstand months of quiescence inside the egg where they depend on stored maternal reserves. A. aegypti mosquitoes are frequently associated with urban habitats that may contain significant metal pollution. Therefore, the duration of quiescence and extent of nutritional depletion may affect the physiology and survival of larvae that hatch in a suboptimal habitat. The aim of this study was to determine the effect of an extended quiescence on larval nutrient reserves and the subsequent effects of metal exposure on larval fitness, survival and development. We hypothesized that an extended quiescence would reduce nutritional reserves and alter the molecular response to metal exposure thereby reducing larval survival and altering larval development. As a molecular marker for metal stress responses, we evaluated transcriptional changes in the metallothionein gene (AaMtn) in response to quiescence and metal exposure. Extended 1st instar quiescence resulted in a significant decrease in lipid reserves and negatively affected larval fitness and development. AaMtn transcription and metal tolerance were compromised in first instars emerged from eggs that had undergone an extended quiescence. These findings suggest that newly emerged mosquito larvae that had survived a relatively long pharate 1st instar quiescence (as might occur during a dry season) are more vulnerable to environmental stress. Pharate 1st instar quiescence could have implications for vector control strategies. Newly emerged mosquito larvae at the end of the dry season or start of the wet season are physiologically compromised, and therefore potentially more susceptible to vector control strategies than mosquito larvae hatched subsequently throughout the wet season.

  17. Levodopa for idiopathic restless legs syndrome: evidence-based review.

    PubMed

    Conti, Cristiane Fiquene; de Oliveira, Márcio Moysés; Andriolo, Regis Bruni; Saconato, Humberto; Atallah, Alvaro Nagib; Valbuza, Juliana Spelta; Coin de Carvalho, Luciane Bizari; do Prado, Gilmar Fernandes

    2007-10-15

    Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. The prevalence of RLS is estimated at 2.7 to 5% of adults and it is more common in women. The treatment of RLS with levodopa has been reported thus a systematic synthesis of evidence is necessary to evaluate the effectiveness and safety of levodopa for RLS. Systematic review of randomized or quasi-randomized, double blind trials on levodopa. Relief of restless legs symptoms marked on a validated scale, subjective sleep quality, sleep quality measured by night polysomnography and actigraphy, quality of life measured by subjective measures, adverse events associated with the treatments. Nine eligible clinical trials were included. The subjective analyses of these studies showed contradictory results, although the objective analyses showed that treatment group had a statistically significant improvement of periodic leg movement (PLM) index, favoring the treatment group. The most commonly adverse event seen was gastrointestinal symptoms. The short-term treatment with levodopa was demonstrated effective and safety for PLM, but there was only few trials assessing long-term treatment and the augmentation phenomenon in RLS. Further long-term randomized controlled trials using standard follow-up measurements as the International RLS Study Group Rating Scale are necessary.

  18. Actigraph Evaluation of Acupuncture for Treating Restless Legs Syndrome

    PubMed Central

    Wang, Mingzhe; Li, Mao; Wang, Qiudong; Kwak, Shin; Jiang, Wenfei; Yamamoto, Yoshiharu

    2015-01-01

    We evaluated the effects of acupuncture in patients with restless legs syndrome (RLS) by actigraph recordings. Among the 38 patients with RLS enrolled, 31 (M = 12, F = 19; mean age, 47.2 ± 9.7 years old) completed the study. Patients were treated with either standard acupuncture (n = 15) or randomized acupuncture (n = 16) in a single-blind manner for 6 weeks. Changes in nocturnal activity (NA) and early sleep activity (ESA) between week 0 (baseline), week 2, week 4, and week 6 were assessed using leg actigraph recordings, the International Restless Legs Syndrome Rating Scale (IRLSRS), and Epworth Sleepiness Scale (ESS). Standard but not randomized acupuncture reduced the abnormal leg activity of NA and ESA significantly in week 2, week 4, and week 6 based on the changes in the clinical scores for IRLSRS and ESS in week 4 and week 6 compared with the baseline. No side effects were observed. The results indicate that standard acupuncture might improve the abnormal leg activity in RLS patients and thus is a potentially suitable integrative treatment for long-term use. PMID:25763089

  19. Is There an Association between Restless Legs Syndrome and Urticaria?

    PubMed

    Tuna, Serpil; Alan, Sevil; Samancı, Nehir; Karakaş, Ayşe Akman

    2016-05-01

    Restless legs syndrome (RLS) is a disease characterized by the urge to move the legs and sleep disturbances. Similarly, chronic spontaneous urticaria (CSU) is a dermatological disease characterized by pruritus and sleep disorders. In this study, we aimed to determine the prevalence and severity of RLS in patients with chronic spontaneous urticaria (CSU) and to compare the quality of sleep of patients with and without RLS in the CSU group using the Pittsburgh Sleep Quality Index. A total of 130 patients with CSU and 100 healthy controls were included in this study. The frequency of RLS, frequency of sleep disturbances, and average score of RLS in patients with CSU were statistically significantly higher than control groups (respectively P = 0.008, P = 0.009, P = 0.004). Subjective sleep quality, sleep latency and habitual sleep efficiency scores in patients with RLS were statistically significantly higher than patients without RLS (respectively P = 0.016, P = 0.007, P = 0.035). We claimed that pruritus of urticaria may decrease the quality of sleep in patients with RLS and it may trigger and worsen the restless legs syndrome. Furthermore, RLS and CSU may share a common etiology.

  20. Is There an Association between Restless Legs Syndrome and Urticaria?

    PubMed Central

    2016-01-01

    Restless legs syndrome (RLS) is a disease characterized by the urge to move the legs and sleep disturbances. Similarly, chronic spontaneous urticaria (CSU) is a dermatological disease characterized by pruritus and sleep disorders. In this study, we aimed to determine the prevalence and severity of RLS in patients with chronic spontaneous urticaria (CSU) and to compare the quality of sleep of patients with and without RLS in the CSU group using the Pittsburgh Sleep Quality Index. A total of 130 patients with CSU and 100 healthy controls were included in this study. The frequency of RLS, frequency of sleep disturbances, and average score of RLS in patients with CSU were statistically significantly higher than control groups (respectively P = 0.008, P = 0.009, P = 0.004). Subjective sleep quality, sleep latency and habitual sleep efficiency scores in patients with RLS were statistically significantly higher than patients without RLS (respectively P = 0.016, P = 0.007, P = 0.035). We claimed that pruritus of urticaria may decrease the quality of sleep in patients with RLS and it may trigger and worsen the restless legs syndrome. Furthermore, RLS and CSU may share a common etiology. PMID:27134503

  1. Relativistic outflow from two thermonuclear shell flashes on neutron stars

    NASA Astrophysics Data System (ADS)

    in't Zand, J. J. M.; Keek, L.; Cavecchi, Y.

    2014-08-01

    We study the exceptionally short (32-43 ms) precursors of two intermediate-duration thermonuclear X-ray bursts observed with the Rossi X-ray Timing Explorer from the neutron stars in 4U 0614+09 and 2S 0918-549. They exhibit photon fluxes that surpass those at the Eddington limit later in the burst by factors of 2.6 to 3.1. We are able to explain both the short duration and the super-Eddington flux by mildly relativistic outflow velocities of 0.1c to 0.3c subsequent to the thermonuclear shell flashes on the neutron stars. These are the highest velocities ever measured from any thermonuclear flash. The precursor rise times are also exceptionally short: about 1 ms. This is inconsistent with predictions for nuclear flames spreading laterally as deflagrations and suggests detonations instead. This is the first time that a detonation is suggested for such a shallow ignition column depth (yign ≈ 1010 g cm-2). The detonation would possibly require a faster nuclear reaction chain, such as bypassing the α-capture on 12C with the much faster 12C(p,γ)13N(α,p)16O process previously proposed. We confirm the possibility of a detonation, albeit only in the radial direction, through the simulation of the nuclear burning with a large nuclear network and at the appropriate ignition depth, although it remains to be seen whether the Zel'dovich criterion is met. A detonation would also provide the fast flame spreading over the surface of the neutron star to allow for the short rise times. This needs to be supported by future two-dimensional calculations of flame spreading at the relevant column depth. As an alternative to the detonation scenario, we speculate on the possibility that the whole neutron star surface burns almost instantly in the auto-ignition regime. This is motivated by the presence of 150 ms precursors with 30 ms rise times in some superexpansion bursts from 4U 1820-30 at low ignition column depths of ~108 g cm-2.

  2. Do we understand children's restlessness? Constructing ecologically valid understandings through reflexive cooperation

    PubMed Central

    Binder, Per-Einar; Stige, Brynjulf

    2015-01-01

    Attention-deficit/hyperactivity disorder (ADHD) is the most widely used children's mental health diagnosis today, but the validity of the diagnosis is controversial, for instance, because it might conceal relational and ecological dimensions of restlessness. We invited parents and professionals from one local community in western Norway to participate in cooperative group discussions on how to conceptualize and understand children's restlessness. We carried out a thematic and reflexive analysis of the cooperative group discussions on ADHD and children's restlessness, and present findings related to three ecological levels inspired by Bronfenbrenner's ecological systems model. At the level of the individual, restlessness was discussed as individual trait, as the expectation to be seen and heard, and as a result of traumatization. At the level of dyad, group or family, restlessness was discussed as a relational phenomenon and as parents' problems. At the level of community, restlessness was discussed as lack of cooperation and lack of structures or resources. Our findings show how contextualized and cooperative reflexivity can contribute to more valid understandings of children's restlessness, and how cooperative inquiry can stimulate reflections about solidarity and sustainability in relation to adult's actions. PMID:26701898

  3. Persistent genital arousal and restless genitalia: sexual dysfunction or subtype of vulvodynia?

    PubMed

    Markos, A R; Dinsmore, Wallace

    2013-11-01

    We conducted a literature review of patients' conditions described under persistent genital arousal disorder and restless genital syndrome, vulvodynia and male genital skin pain of unknown aetiology (penoscrotodynia). Our aim is to improve the understanding of the condition, unify nomenclature and promote evidence-based practice. The most prominent symptom in persistent genital arousal disorder and restless genital syndrome is a spontaneous, unwelcomed, intrusive and distressing vulval sensation. There are similarities between the clinical presentation of vulvodynia, penoscrotodynia, persistent genital arousal disorder and restless genital syndrome patients. The aetiology of persistent genital arousal disorder and restless genital syndrome, similar to vulvodynia, could be better explained in terms of neuro-vascular dysfunction, genital peripheral neuropathy and/or dysfunctional micro-vascular arterio-venous shunting. Erythromelalgia lends itself to explain some cases of restless genital syndrome, who have concurrent restless legs syndrome; and therefore draw parallels with the red scrotum syndrome. The published literature supports the concept of classifying restless genital syndrome as a sub-type of vulvodynia rather than sexual dysfunction.

  4. Diapause and quiescence in Lutzomyia diabolica (Diptera:Psychodidae).

    PubMed

    Lawyer, P; Young, D

    1991-12-01

    Gravid, laboratory-reared Lutzomyia diabolica from Garner State Park, Texas, oviposited from May to December in an outdoor colony cage at Gainesville, Florida. Egg batches contained 100% fast-developing (nondiapause) eggs, a mixture of fast-developing and slow-developing (diapause) eggs, or 100% slow-developing eggs, depending on the time of year laid. The percent diapause eggs per batch increased from 0% in early October to 100% by December. These observations suggest that Lu. diabolica is a long-day species, depositing diapause eggs in response to shorter day length. Temperature may also modify the degree of diapause response by altering the calendar position of the critical day length. Termination of the winter diapause is probably temperature dependent. Quiescence was observed in 3rd and 4th stage larvae in both indoor and outdoor cultures and was usually associated with adverse conditions such as excessive moisture, extreme temperatures, or poor diet.

  5. A spectrophotometric study of IR Gem at outburst and quiescence

    NASA Technical Reports Server (NTRS)

    Feinswog, Laurie; Szkody, Paula; Garnavich, Peter

    1988-01-01

    Optical spectra with 2.5-A resolution obtained throughout the orbit of IR Gem during a five-day sequence beginning at an outburst state and ending at quiescence are compared with B magnitude and IUE spectra obtained throughout other quiescent-state orbits. No obvious second component is found in the emission lines. In contrast to previous results, little high-excitation He II 4686-A emission is noted, and no variation of the equivalent widths of the Balmer emission is found over the orbital cycle. The results suggest that large changes in the excitation level and in the modulation from a heated zone can take place during different quiescent states, possibly due to the interoutburst phase.

  6. Is HL Tauri and FU Orionis system in quiescence?

    NASA Technical Reports Server (NTRS)

    Lin, D. N. C.; Hayashi, M.; Bell, K. R.; Ohashi, N.

    1994-01-01

    A recent Nobeyama map of HL Tau reveals that gas is infalling in a flattened region approximately 1400 AU around the central star. The apparent motion of the gas provides the necessary condition for the formation of a Keplerian disk with a radius comparable to the size of the primordial solar nebula. The inferred mass infall rate onto the disk is approximately equal to 5 x 10(exp -6) solar mass/yr, which greatly exceeds the maximum estimate of the accretion rate onto the central star (approximately 7 x 10(exp -7) solar mass/yr). Consequently, mass must currently be accumulating in the disk. The estimated age and disk mass of HL Tau suggest that the accumulated matter has been flushed repeatedly on a timescale less than 10(exp 4) yr. Based on the similarites between their evolution patterns, we propose that HL Tau is an FU Orionis system in quiescence. In addition to HL Tau, 14 out of 86 pre-main-sequence stars in the Taurus-Auriga dark clouds have infrared luminosities much greater than their otherwise normal extinction-corrected stellar luminosities. These sources also tend to have flat spectra which may be due to the reprocessing of radiation by dusty, flattened, collapsing envelopes with infall rates a few 10(exp -6) solar mass/yr. Such rates are much larger than estimated central accretion rates for these systems, which suggests that mass must also be accumulating in these disks. If these sources are FU Orionis stars in quiescence, similar to HL Tau, their age and relative abundance imply that the FU Orionis phase occurs over a timescale of approixmately 10(exp 5) yr, and the quiescent phase between each outburst lasts approximately 10(exp 3) =10(exp 4) yr. These inferred properties are compatible with the scenario that FU Orionis outbursts are regulated by a thermal instability in the inner region of the disk.

  7. Evaluation of a seismic quiescence pattern in southeastern sicily

    NASA Astrophysics Data System (ADS)

    Mulargia, F.; Broccio, F.; Achilli, V.; Baldi, P.

    1985-07-01

    Southeastern Sicily experienced a very peculiar seismic activity in historic times, with a long series of ruinous earthquakes. A last large event, with magnitude probably in excess of 7.5, occurred on Jan., 11, 1693, totally destroying the city of Catania and killing 60,000 people. Only a few moderate events were reported since then, and a seismic gap issue has been proposed on this basis. A close scrutiny of the available data further shows that all significant seismic activity ceased after year 1850, suggesting one of the largest quiescence patterns ever encountered. This is examined together with the complex tectonic setting of the region, characterized by a wrenching mechanism with most significant seismicity located in its northern graben structure. An attempt to ascertain the imminence and the size of a future earthquake through commonly accepted empirical relations based on size and duration of the quiescence pattern did not provide any feasible result. A precision levelling survey which we recently completed yielded a relative subsidence of ~ 3 mm/yr, consistent with an aseismic slip on the northern graben structure at a rate of ~ 15 mm/yr. Comparing these results with sedimentological and tidal data suggests that the area is undergoing an accelerated deformation process; this issue is further supported by Rikitake's ultimate strain statistics. If the imminence of a damaging ( M = 5.4) event is strongly favoured by Weibull statistics applied to the time series of occurrence of large events, the accumulated strain does not appear sufficient for a large earthquake ( M ⪸ 7.0). Within the limits of reliability of present semi-empirical approaches we conclude that the available evidence is consistent with the occurrence of a moderate-to-large ( M ≅ 6.0) event in the near future. Several questions regarding the application of simple models to real (and complex) tectonic settings remain nevertheless unanswered.

  8. Transport simulation of ITER (International Thermonuclear Engineering Reactor) startup

    SciTech Connect

    Attenberger, S.E.; Houlberg, W.A.

    1989-01-01

    The present International Thermonuclear Engineering Reactor (ITER) reference configurations are the Technology Phase,'' in which the plasma current is maintained noninductively at a subignition density, and the Physics Phase,'' which is ignited but requires inductive maintenance of the current. The WHIST 1.5-D transport code is used to evaluate the volt-second requirements of both configurations. A slow current ramp (60-80's) is required for fixed-radius startup in ITER to avoid hollow current density profiles. To reach the operating point requires about 203 V{center dot}s for the Technology Phase (18 MA) and about 270 V{center dot}s for the Physics Phase (22 MA). The resistive losses can be reduced with expanding-radius startup. 5 refs., 4 figs.

  9. Close Binary Progenitors and Ejected Companions of Thermonuclear Supernovae

    NASA Astrophysics Data System (ADS)

    Geier, S.; Kupfer, T.; Heber, U.; Nemeth, P.; Ziegerer, E.; Irrgang, A.; Schindewolf, M.; Marsh, T. R.; Gänsicke, B. T.; Barlow, B. N.; Bloemen, S.

    2017-03-01

    Hot subdwarf stars (sdO/Bs) are evolved core helium-burning stars with very thin hydrogen envelopes, which can be formed by common envelope ejection. Close sdB binaries with massive white dwarf (WD) companions are potential progenitors of thermonuclear supernovae type Ia (SN Ia). We discovered such a progenitor candidate as well as a candidate for a surviving companion star, which escapes from the Galaxy. More candidates for both types of objects have been found by cross-matching known sdB stars with proper motion and light curve catalogues. We found 72 sdO/B candidates with high Galactic restframe velocities, 12 of them might be unbound to our Galaxy. Furthermore, we discovered the second-most compact sdB+WD binary known. However, due to the low mass of the WD companion, it is unlikely to be a SN Ia progenitor.

  10. Multidimensional Simulations of Thermonuclear Supernovae from the First Stars

    NASA Astrophysics Data System (ADS)

    Chen, K. J.; Heger, A.; Almgren, A.

    2012-07-01

    Theoretical models suggest that the first stars in the universe could have been very massive, with typical masses ≥ 100 M⊙ . Many of them might have died as energetic thermonuclear explosions known as pair-instability supernovae (PSNe). We present multidimensional numerical simulations of PSNe with the new radiation-hydrodynamics code CASTRO. Our models capture all explosive burning and follow the explosion until the shock breaks out from the stellar surface. We find that fluid instabilities driven by oxygen and helium burning arise at the upper and lower boundaries of the oxygen shell ˜ 20 - 100 sec after the explosion begins. Later, when the shock reaches the hydrogen envelope a strong reverse shock forms that rapidly develops additional Rayleigh-Taylor instabilities. In red supergiant progenitors, the amplitudes of these instabilities are sufficient to mix the supernova's ejecta and alter its observational signature. Our results provide useful predictions for the detection of PSNe by forthcoming telescopes.

  11. Acoustically driven spherical implosions and the possibility of thermonuclear reactions

    NASA Astrophysics Data System (ADS)

    Gaitan, D. Felipe; Tessien, Ross

    2003-04-01

    Acoustically driven, gas-filled cavities in liquids have been known to collapse violently, generating short flashes of light of ~100-ps duration. More recently, the possibility of generating fusion reactions using acoustics (acoustic inertial confinement fusion) has been considered. Results of computer simulations using the HYADES hydrocode (Cascade Applied Sciences, Inc) plus the SESAME equations of state for free collapsing and acoustically driven cavities in molten metals will be presented as well as experimental data at high ambient pressures in different liquids. Back-of-the-envelope calculations in terms of the acoustical and thermodynamic parameters necessary to achieve thermonuclear reactions will be presented in an effort to evaluate the feasibility of acoustic ICF as an energy source.

  12. Current drive at plasma densities required for thermonuclear reactors.

    PubMed

    Cesario, R; Amicucci, L; Cardinali, A; Castaldo, C; Marinucci, M; Panaccione, L; Santini, F; Tudisco, O; Apicella, M L; Calabrò, G; Cianfarani, C; Frigione, D; Galli, A; Mazzitelli, G; Mazzotta, C; Pericoli, V; Schettini, G; Tuccillo, A A

    2010-08-10

    Progress in thermonuclear fusion energy research based on deuterium plasmas magnetically confined in toroidal tokamak devices requires the development of efficient current drive methods. Previous experiments have shown that plasma current can be driven effectively by externally launched radio frequency power coupled to lower hybrid plasma waves. However, at the high plasma densities required for fusion power plants, the coupled radio frequency power does not penetrate into the plasma core, possibly because of strong wave interactions with the plasma edge. Here we show experiments performed on FTU (Frascati Tokamak Upgrade) based on theoretical predictions that nonlinear interactions diminish when the peripheral plasma electron temperature is high, allowing significant wave penetration at high density. The results show that the coupled radio frequency power can penetrate into high-density plasmas due to weaker plasma edge effects, thus extending the effective range of lower hybrid current drive towards the domain relevant for fusion reactors.

  13. On some features of plane waves of thermonuclear burn

    NASA Astrophysics Data System (ADS)

    Khishchenko, K. V.; Charakhch'yan, A. A.

    2015-01-01

    The behavior of a slow burn wave propagating over a precompressed thermonuclear fuel heated by several shock waves generated by a laser pulse is studied. It is shown that such a burn wave can rapidly increase the fuel density ahead of the wave front and transform to a pair of detonation waves moving in the opposite directions. Hydrodynamic equations with a linear velocity profile are solved. It is found that the proton beam intensity necessary for ignition increases with the initial fuel density in accordance with the known formula generalizing results of two-dimensional simulations. A possibility of using results of one-dimensional simulations for determining the energy of ignition of a cylindrical target is discussed.

  14. Multiplexing thermography for International Thermonuclear Experimental Reactor divertor targets

    SciTech Connect

    Itami, K.; Sugie, T.; Vayakis, G.; Walker, C.

    2004-10-01

    The concept of multiplexing thermography is applied to the design of the divertor thermography system for International Thermonuclear Experimental Reactor (ITER). The combination of the front mirror with multiellipticity and a Czerney-Turner spectrometer with a 0.2 mm pitched multichannel detector enables a spatial resolution of 3 mm and a time resolution of 20 {mu}s above a target temperature of 300 deg. C to be achieved. This should be sufficient to measure ELM heat fluxes to the targets in ITER. To satisfy the measurement requirement, it is very important to keep an accurate alignment around the optical axis against movement of the vessel during the plasma discharges. Several key engineering problems, such as the survivability of components against mirror coating by redeposited divertor material, remain to be solved. Potential solutions have been identified.

  15. Laser induced sonofusion: A new road toward thermonuclear reactions

    NASA Astrophysics Data System (ADS)

    Sadighi-Bonabi, Rasoul; Gheshlaghi, Maryam

    2016-03-01

    The Possibility of the laser assisted sonofusion is studied via single bubble sonoluminescence (SBSL) in Deuterated acetone (C3D6O) using quasi-adiabatic and hydro-chemical simulations at the ambient temperatures of 0 and -28.5 °C. The interior temperature of the produced bubbles in Deuterated acetone is 1.6 × 106 K in hydro-chemical model and it is reached up to 1.9 × 106 K in the laser induced SBSL bubbles. Under these circumstances, temperature up to 107 K can be produced in the center of the bubble in which the thermonuclear D-D fusion reactions are promising under the controlled conditions.

  16. Analytical Model for the Thermonuclear Instability in IGNITOR

    NASA Astrophysics Data System (ADS)

    Cardinali, A.; Sonnino, G.; Coppi, B.

    2013-10-01

    The non-linear energy balance equation for thermal equilibrium and stability, is analytically and numerically investigated in order to study the thermonuclear instability in the IGNITOR experiment facility. The expressions for the ion and the electron thermal coefficients, introduced in the thermal energy balance equation, are obtained by solving the nonlinear transport equations relevant to several collisional transport regimes (in particular the banana regime). The differential equation for the temperature profile at equilibrium is solved and the resulting profile is compared with the results obtained by a full transport code. The growth of the perturbation in the temperature is analyzed by integrating the equation in time. A scenario is considered where IGNITOR is led to operate in a slightly sub-critical regime by adding a small fraction of 3He to the nominal 50-50 Deuterium-Tritium mixture and heating the plasma by ICRH power. Sponsored in part by the US DOE.

  17. The Dynamic Mutation Characteristics of Thermonuclear Reaction in Tokamak

    PubMed Central

    Li, Jing; Quan, Tingting; Zhang, Wei; Deng, Wei

    2014-01-01

    The stability and bifurcations of multiple limit cycles for the physical model of thermonuclear reaction in Tokamak are investigated in this paper. The one-dimensional Ginzburg-Landau type perturbed diffusion equations for the density of the plasma and the radial electric field near the plasma edge in Tokamak are established. First, the equations are transformed to the average equations with the method of multiple scales and the average equations turn to be a Z2-symmetric perturbed polynomial Hamiltonian system of degree 5. Then, with the bifurcations theory and method of detection function, the qualitative behavior of the unperturbed system and the number of the limit cycles of the perturbed system for certain groups of parameter are analyzed. At last, the stability of the limit cycles is studied and the physical meaning of Tokamak equations under these parameter groups is given. PMID:24892099

  18. The dynamic mutation characteristics of thermonuclear reaction in Tokamak.

    PubMed

    Li, Jing; Quan, Tingting; Zhang, Wei; Deng, Wei

    2014-01-01

    The stability and bifurcations of multiple limit cycles for the physical model of thermonuclear reaction in Tokamak are investigated in this paper. The one-dimensional Ginzburg-Landau type perturbed diffusion equations for the density of the plasma and the radial electric field near the plasma edge in Tokamak are established. First, the equations are transformed to the average equations with the method of multiple scales and the average equations turn to be a Z 2-symmetric perturbed polynomial Hamiltonian system of degree 5. Then, with the bifurcations theory and method of detection function, the qualitative behavior of the unperturbed system and the number of the limit cycles of the perturbed system for certain groups of parameter are analyzed. At last, the stability of the limit cycles is studied and the physical meaning of Tokamak equations under these parameter groups is given.

  19. Demonstration of thermonuclear conditions in magnetized liner inertial fusion experimentsa)

    NASA Astrophysics Data System (ADS)

    Gomez, M. R.; Slutz, S. A.; Sefkow, A. B.; Hahn, K. D.; Hansen, S. B.; Knapp, P. F.; Schmit, P. F.; Ruiz, C. L.; Sinars, D. B.; Harding, E. C.; Jennings, C. A.; Awe, T. J.; Geissel, M.; Rovang, D. C.; Smith, I. C.; Chandler, G. A.; Cooper, G. W.; Cuneo, M. E.; Harvey-Thompson, A. J.; Herrmann, M. C.; Hess, M. H.; Lamppa, D. C.; Martin, M. R.; McBride, R. D.; Peterson, K. J.; Porter, J. L.; Rochau, G. A.; Savage, M. E.; Schroen, D. G.; Stygar, W. A.; Vesey, R. A.

    2015-05-01

    The magnetized liner inertial fusion concept [S. A. Slutz et al., Phys. Plasmas 17, 056303 (2010)] utilizes a magnetic field and laser heating to relax the pressure requirements of inertial confinement fusion. The first experiments to test the concept [M. R. Gomez et al., Phys. Rev. Lett. 113, 155003 (2014)] were conducted utilizing the 19 MA, 100 ns Z machine, the 2.5 kJ, 1 TW Z Beamlet laser, and the 10 T Applied B-field on Z system. Despite an estimated implosion velocity of only 70 km/s in these experiments, electron and ion temperatures at stagnation were as high as 3 keV, and thermonuclear deuterium-deuterium neutron yields up to 2 × 1012 have been produced. X-ray emission from the fuel at stagnation had widths ranging from 50 to 110 μm over a roughly 80% of the axial extent of the target (6-8 mm) and lasted approximately 2 ns. X-ray yields from these experiments are consistent with a stagnation density of the hot fuel equal to 0.2-0.4 g/cm3. In these experiments, up to 5 × 1010 secondary deuterium-tritium neutrons were produced. Given that the areal density of the plasma was approximately 1-2 mg/cm2, this indicates the stagnation plasma was significantly magnetized, which is consistent with the anisotropy observed in the deuterium-tritium neutron spectra. Control experiments where the laser and/or magnetic field were not utilized failed to produce stagnation temperatures greater than 1 keV and primary deuterium-deuterium yields greater than 1010. An additional control experiment where the fuel contained a sufficient dopant fraction to substantially increase radiative losses also failed to produce a relevant stagnation temperature. The results of these experiments are consistent with a thermonuclear neutron source.

  20. The Internal Structure and Propagation of Magnetohydrodynamical Thermonuclear Flames

    NASA Astrophysics Data System (ADS)

    Remming, Ian S.; Khokhlov, Alexei M.

    2016-11-01

    We present general equations for non-ideal, reactive flow magnetohydrodynamics (RFMHD) in the form best suited for describing thermonuclear combustion in high-density degenerate matter of SNe Ia. The relative importance of various non-ideal effects is analyzed as a function of characteristic spatial and temporal scales of the problem. From the general RFMHD equations, we derive the one-dimensional ordinary differential equations describing the steady-state propagation of a planar thermonuclear flame front in a magnetic field. The physics of the flame is first studied qualitatively using a simple case of one-step Arrhenius kinetics, a perfect gas equation of state (EOS), and constant thermal conductivity coefficients. After that, the equations are solved, the internal flame front structure is calculated, and the flame velocity, S l , and flame thickness, δ l , are found for carbon-oxygen degenerate material of supernovae using a realistic EOS, transport properties, and detailed nuclear kinetics. The magnetic field changes the flame behavior significantly, both qualitatively and quantitatively, as compared to the non-magnetic case of classical combustion. (1) The magnetic field influences the evolutionarity of a flame front and makes it impossible for a flame to propagate steadily in a wide range of magnetic field strengths and orientations relative to the front. (2) When the flame moves steadily, it can propagate in several distinct modes, the most important being the slow C S and super-Alfvénic C sup modes. (3) The speed of the flame can be diminished or enhanced by up to several factors relative to the non-magnetic laminar flame speed.

  1. Demonstration of thermonuclear conditions in magnetized liner inertial fusion experiments

    DOE PAGES

    Gomez, Matthew R.; Slutz, Stephen A.; Sefkow, Adam B.; ...

    2015-04-29

    In this study, the magnetized liner inertial fusion concept [S. A. Slutz et al., Phys. Plasmas17, 056303 (2010)] utilizes a magnetic field and laser heating to relax the pressure requirements of inertial confinement fusion. The first experiments to test the concept [M. R. Gomez et al., Phys. Rev. Lett. 113, 155003 (2014)] were conducted utilizing the 19 MA, 100 ns Z machine, the 2.5 kJ, 1 TW Z Beamlet laser, and the 10 T Applied B-field on Z system. Despite an estimated implosion velocity of only 70 km/s in these experiments, electron and ion temperatures at stagnation were as highmore » as 3 keV, and thermonuclear deuterium-deuterium neutron yields up to 2 × 1012 have been produced. X-ray emission from the fuel at stagnation had widths ranging from 50 to 110 μm over a roughly 80% of the axial extent of the target (6–8 mm) and lasted approximately 2 ns. X-ray yields from these experiments are consistent with a stagnation density of the hot fuel equal to 0.2–0.4 g/cm3. In these experiments, up to 5 ×1010 secondary deuterium-tritium neutrons were produced. Given that the areal density of the plasma was approximately 1–2 mg/cm2, this indicates the stagnation plasma was significantly magnetized, which is consistent with the anisotropy observed in the deuterium-tritium neutron spectra. Control experiments where the laser and/or magnetic field were not utilized failed to produce stagnation temperatures greater than 1 keV and primary deuterium-deuterium yields greater than 1010. An additional control experiment where the fuel contained a sufficient dopant fraction to substantially increase radiative losses also failed to produce a relevant stagnation temperature. The results of these experiments are consistent with a thermonuclear neutron source.« less

  2. Pathological gambling plus hypersexuality in restless legs syndrome: a new case.

    PubMed

    d'Orsi, Giuseppe; Demaio, Vincenzo; Specchio, L M

    2011-08-01

    Emerging clinical data indicate that dopaminergic agonists used to treat restless legs syndrome may be associated with dopamine dysregulation syndrome, particularly pathological gambling. We report a new case with pathological gambling plus hypersexuality and impotence in an old patient treated with a small dose (0.18 mg daily at bedtime) of pramipexole for restless legs syndrome for 5 months. The time relationship and the resolution upon discontinuation of dopaminergic agonists suggest a causative association. Our new case confirms that restless legs syndrome patients should be cautioned about potential dopamine dysregulation syndrome coinciding with dopaminergic agonists, as it can be reversed by drug withdrawal.

  3. Aedes aegypti pharate 1st instar quiescence: a case for anticipatory reproductive plasticity.

    PubMed

    Perez, Mario H; Noriega, Fernando G

    2013-03-01

    Aedes aegypti mosquitoes use pharate 1st instar quiescence to cope with fluctuations in water availability hosting a fully developed 1st instar larvae within the chorion. The duration of this quiescence has been shown to affect larval fitness. This study sought to determine if an extended egg quiescence can elicit a plastic response resulting in an adult phenotype distinct from adults reared from short quiescence eggs. Our findings indicate that extended pharate 1st instar quiescence affects the performance and reproductive fitness of the adult female mosquito as well as the nutritional status of its progeny via maternal effects in an adaptive manner. This study demonstrates that phenotypic plasticity results as a consequence of the duration of pharate 1st instar quiescence and alternative phenotypes may exist for this mosquito with quiescence serving as a cue possibly signaling the environmental conditions that follow a dry period. These findings have implications for A. aegypti's success as a vector, geographic distribution, vector capacity and control.

  4. Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch

    PubMed Central

    Seidel, Hannah S; Kimble, Judith

    2015-01-01

    Many types of adult stem cells exist in a state of cell-cycle quiescence, yet it has remained unclear whether quiescence plays a role in maintaining the stem cell fate. Here we establish the adult germline of Caenorhabditis elegans as a model for facultative stem cell quiescence. We find that mitotically dividing germ cells—including germline stem cells—become quiescent in the absence of food. This quiescence is characterized by a slowing of S phase, a block to M-phase entry, and the ability to re-enter M phase rapidly in response to re-feeding. Further, we demonstrate that cell-cycle quiescence alters the genetic requirements for stem cell maintenance: The signaling pathway required for stem cell maintenance under fed conditions—GLP-1/Notch signaling—becomes dispensable under conditions of quiescence. Thus, cell-cycle quiescence can itself maintain stem cells, independent of the signaling pathway otherwise essential for such maintenance. DOI: http://dx.doi.org/10.7554/eLife.10832.001 PMID:26551561

  5. Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States.

    PubMed

    Trojanowski, Nicholas F; Nelson, Matthew D; Flavell, Steven W; Fang-Yen, Christopher; Raizen, David M

    2015-10-28

    Electrophysiological recordings have enabled identification of physiologically distinct yet behaviorally similar states of mammalian sleep. In contrast, sleep in nonmammals has generally been identified behaviorally and therefore regarded as a physiologically uniform state characterized by quiescence of feeding and locomotion, reduced responsiveness, and rapid reversibility. The nematode Caenorhabditis elegans displays sleep-like quiescent behavior under two conditions: developmentally timed quiescence (DTQ) occurs during larval transitions, and stress-induced quiescence (SIQ) occurs in response to exposure to cellular stressors. Behaviorally, DTQ and SIQ appear identical. Here, we use optogenetic manipulations of neuronal and muscular activity, pharmacology, and genetic perturbations to uncover circuit and molecular mechanisms of DTQ and SIQ. We find that locomotion quiescence induced by DTQ- and SIQ-associated neuropeptides occurs via their action on the nervous system, although their neuronal target(s) and/or molecular mechanisms likely differ. Feeding quiescence during DTQ results from a loss of pharyngeal muscle excitability, whereas feeding quiescence during SIQ results from a loss of excitability in the nervous system. Together these results indicate that, as in mammals, quiescence is subserved by different mechanisms during distinct sleep-like states in C. elegans.

  6. Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States

    PubMed Central

    Trojanowski, Nicholas F.; Nelson, Matthew D.; Flavell, Steven W.

    2015-01-01

    Electrophysiological recordings have enabled identification of physiologically distinct yet behaviorally similar states of mammalian sleep. In contrast, sleep in nonmammals has generally been identified behaviorally and therefore regarded as a physiologically uniform state characterized by quiescence of feeding and locomotion, reduced responsiveness, and rapid reversibility. The nematode Caenorhabditis elegans displays sleep-like quiescent behavior under two conditions: developmentally timed quiescence (DTQ) occurs during larval transitions, and stress-induced quiescence (SIQ) occurs in response to exposure to cellular stressors. Behaviorally, DTQ and SIQ appear identical. Here, we use optogenetic manipulations of neuronal and muscular activity, pharmacology, and genetic perturbations to uncover circuit and molecular mechanisms of DTQ and SIQ. We find that locomotion quiescence induced by DTQ- and SIQ-associated neuropeptides occurs via their action on the nervous system, although their neuronal target(s) and/or molecular mechanisms likely differ. Feeding quiescence during DTQ results from a loss of pharyngeal muscle excitability, whereas feeding quiescence during SIQ results from a loss of excitability in the nervous system. Together these results indicate that, as in mammals, quiescence is subserved by different mechanisms during distinct sleep-like states in C. elegans. SIGNIFICANCE STATEMENT Sleep behavior is characterized by cessation of feeding and locomotion, reduced responsiveness, and rapid reversibility. In mammals and birds, there are sleep states that have fundamentally different electrophysiology despite outwardly similar behavior. However, it is not clear whether behavioral sleep is a uniform state in animals in which electrophysiology is not readily possible. The nematode Caenorhabditis elegans displays sleep-like behavior under two conditions: during development and after exposure to environmental stressors. Here, we show that feeding and locomotion

  7. Search for thermonuclear neutrons in a mega-ampere plasma focus

    NASA Astrophysics Data System (ADS)

    Klir, D.; Kubes, P.; Paduch, M.; Pisarczyk, T.; Chodukowski, T.; Scholz, M.; Kalinowska, Z.; Bienkowska, B.; Karpinski, L.; Kortanek, J.; Kravarik, J.; Rezac, K.; Ivanova-Stanik, I.; Tomaszewski, K.; Zielinska, E.

    2012-01-01

    Plasma focus experiments were carried out at a modified PF-1000 where the cathode disc was added in front of the anode. Experimental results indicated a fraction of thermonuclear neutrons on the mega-ampere current level. In order to prove the thermonuclear mechanism, the time of neutron production and the neutron energy spectrum were measured by time-of-flight (TOF) diagnostics. Neutron TOF signals showed that the neutron production was a multiphase process and more than one mechanism occurred simultaneously. The occurrence of the thermonuclear mechanism was most evident during the plasma stagnation at low deuterium pressures. At low filling pressures, the narrow width of the neutron energy spectra demonstrated an ion temperature of about 1 keV. The possibility of thermonuclear neutrons was studied also after the stagnation, during the main neutron emission. In this case, the thermonuclear mechanism could be verified by calculating the number of deuterons that participate in the fusion process. For the bulk of thermonuclear plasmas, a significant fraction of plasma should participate in fusion. Finally, the basic consideration of the thermonuclear mechanism in Z-pinches showed the reasonableness of the MagLIF concept.

  8. The biopsychosocial effects of restless legs syndrome (RLS)

    PubMed Central

    Becker, Philip M

    2006-01-01

    The symptoms of restless legs syndrome (RLS) are associated with reductions in patients’ quality of life (QoL) and mental heath. Sleep disturbance, which is often the most troublesome symptom of RLS, may have a negative impact on patients’ daytime cognitive abilities. Research has established a relationship between the symptoms of RLS and mood symptoms, but causality is unclear. Some studies have indicated that the symptoms of RLS precede those of depression or anxiety, and others relate the severity of mood symptoms to the severity of RLS symptoms. Associations between the sleep disturbance produced by RLS and patients’ mood symptoms have also been demonstrated. The impact of RLS symptoms and their treatment on QoL, mental health, and cognition are reviewed herein. PMID:19412498

  9. Restless legs syndrome: a review of clinical and pathophysiologic features.

    PubMed

    Allen, R P; Earley, C J

    2001-03-01

    Restless legs syndrome (RLS), although long ignored and still much underdiagnosed, disrupts the life and sleep considerably of those who have it. Recent clinical and basic research provides for better definition and pathophysiologic understanding of the disorder. The body of knowledge about this disorder has been expanding rapidly during the past decade and it has altered our concepts of this disorder. This review of RLS covers history, diagnosis, morbidity of sleep disturbance, relation to periodic limb movements in both sleep and waking, secondary causes, severity assessment methods, phenotypes for possible genetic patterns, epidemiology, pathophysiology, and medical treatment considerations. The emphasis on pathophysiology includes consideration of central nervous system localization, neurotransmitter and other systems involved, and the role of iron metabolism. Studies to date support the authors' recently advanced iron-dopamine model of RLS.

  10. Restless legs syndrome and periodic limb movement disorder.

    PubMed

    Parker, Kathy P; Rye, David B

    2002-12-01

    Restless leg syndrome and PLMD are nocturnal movement disorders associated with significant adverse effects on the health and well-being of patients and their families [66]. Although the pathophysiological basis remains to be fully described, current research points to abnormalities in CNS function and neurotransmitter systems. The accurate diagnosis of RLS and PMD requires a thorough history, physical examination, diagnostic tests, and often, a referral to a sleep disorders specialist. Considering the prevalence of these conditions and their negative impact, nurses should be well-versed in the assessment and management of these problems as well as in the appropriate education of patients and their families. Nursing research is greatly needed, particularly with regard to the development and testing of biobehavioral interventions designed to decrease associated symptoms and improve clinical outcomes. Finally, because of the complexity of the clinical presentation of RLS and PLMD, this population of patients presents nurse clinicians and researchers alike with an extraordinary opportunity for interdisciplinary collaboration.

  11. Iron's role in paediatric restless legs syndrome - a review.

    PubMed

    Dosman, Cara; Witmans, Manisha; Zwaigenbaum, Lonnie

    2012-04-01

    Paediatric restless legs syndrome (RLS) treatment is important because RLS's associated sleep disturbance causes significant developmental-behavioural morbidity and impacts family well-being. RLS is associated with brain iron insufficiency and dopaminergic dysfunction. Diagnosis requires fulfillment of diagnostic criteria, which for children are currently in evolution, and have limitations, especially in preschoolers. The community physician needs to recognize the possibility of RLS to refer to a sleep specialist for diagnostic confirmation and management recommendations, which include oral iron therapy, even though there is currently no definitive research evidence for iron efficacy in most children with RLS. A 3 mg to 6 mg elemental iron/kg/day dose for three months could be tried if the ferritin level is <50 ug/L. Sleep hygiene and behavioural strategies are also recommended. Iron supplementation should be safe in the absence of iron metabolism disorders, provided that transferrin saturation and ferritin levels are monitored pre-and post-treatment.

  12. Silent Cerebral Small Vessel Disease in Restless Legs Syndrome

    PubMed Central

    Ferri, Raffaele; Cosentino, Filomena I.I.; Moussouttas, Michael; Lanuzza, Bartolo; Aricò, Debora; Bagai, Kanika; Wang, Lily; McLaughlin, BethAnn; Walters, Arthur S.

    2016-01-01

    Study Objectives: Growing literature suggests that patients with restless legs syndrome (RLS) may be at increased risk for hypertension, heart disease, and stroke. Cerebral small vessel disease (SVD) is a known risk factor for clinical stroke. This study evaluated silent cerebral SVD by MRI in patients with RLS, in the absence of a history of previous clinical stroke or known stroke risk factors and taking into account disease duration. Methods: Fifty-three patients with RLS < 10 y were prospectively recruited along with 44 with RLS > 10 y and 74 normal controls. A magnetic resonance imaging study was obtained from all subjects and scans were analyzed for area and volume of SVD. Results: There was a significant increase in SVD area in the entire group of RLS patients compared to controls (P = 0.036); this was almost entirely driven by the group with RLS > 10 y. SVD area and volume were significantly increased in patients with RLS > 10 y with respect to both controls (P < 0.0001 and P < 0.0014, respectively) and RLS < 10 y (P < 0.00022 and P < 0.003, respectively). Age, duration of RLS, and the interaction of age and duration of RLS were independent predictors of SVD disease. Duration of RLS was an independent predictor of the burden of cerebral SVD (area P < 0.00012 and volume P < 0.0025), whereas sex and insomnia were not. Conclusion: RLS duration should be taken into account when analyzing the association between RLS and cerebrovascular disease; our data support the hypothesis that a long-lasting RLS and its accompanying periodic limb movements in sleep are a risk factor for silent SVD and perhaps for the development of clinical stroke. Citation: Ferri R, Cosentino FI, Moussouttas M, Lanuzza B, Aricò D, Bagai K, Wang L, McLaughlin B, Walters AS. Silent cerebral small vessel disease in restless legs syndrome. SLEEP 2016;39(7):1371–1377. PMID:27091527

  13. Demonstration of thermonuclear conditions in magnetized liner inertial fusion experiments

    SciTech Connect

    Gomez, M. R.; Slutz, S. A.; Sefkow, A. B.; Hahn, K. D.; Hansen, S. B.; Knapp, P. F.; Schmit, P. F.; Ruiz, C. L.; Sinars, D. B.; Harding, E. C.; Jennings, C. A.; Awe, T. J.; Geissel, M.; Rovang, D. C.; Smith, I. C.; Chandler, G. A.; Cooper, G. W.; Cuneo, M. E.; Harvey-Thompson, A. J.; Hess, M. H.; and others

    2015-05-15

    The magnetized liner inertial fusion concept [S. A. Slutz et al., Phys. Plasmas 17, 056303 (2010)] utilizes a magnetic field and laser heating to relax the pressure requirements of inertial confinement fusion. The first experiments to test the concept [M. R. Gomez et al., Phys. Rev. Lett. 113, 155003 (2014)] were conducted utilizing the 19 MA, 100 ns Z machine, the 2.5 kJ, 1 TW Z Beamlet laser, and the 10 T Applied B-field on Z system. Despite an estimated implosion velocity of only 70 km/s in these experiments, electron and ion temperatures at stagnation were as high as 3 keV, and thermonuclear deuterium-deuterium neutron yields up to 2 × 10{sup 12} have been produced. X-ray emission from the fuel at stagnation had widths ranging from 50 to 110 μm over a roughly 80% of the axial extent of the target (6–8 mm) and lasted approximately 2 ns. X-ray yields from these experiments are consistent with a stagnation density of the hot fuel equal to 0.2–0.4 g/cm{sup 3}. In these experiments, up to 5 × 10{sup 10} secondary deuterium-tritium neutrons were produced. Given that the areal density of the plasma was approximately 1–2 mg/cm{sup 2}, this indicates the stagnation plasma was significantly magnetized, which is consistent with the anisotropy observed in the deuterium-tritium neutron spectra. Control experiments where the laser and/or magnetic field were not utilized failed to produce stagnation temperatures greater than 1 keV and primary deuterium-deuterium yields greater than 10{sup 10}. An additional control experiment where the fuel contained a sufficient dopant fraction to substantially increase radiative losses also failed to produce a relevant stagnation temperature. The results of these experiments are consistent with a thermonuclear neutron source.

  14. Demonstration of thermonuclear conditions in magnetized liner inertial fusion experiments

    SciTech Connect

    Gomez, Matthew R.; Slutz, Stephen A.; Sefkow, Adam B.; Hahn, Kelly D.; Hansen, Stephanie B.; Knapp, Patrick F.; Schmit, Paul F.; Ruiz, Carlos L.; Sinars, Daniel Brian; Harding, Eric C.; Jennings, Christopher A.; Awe, Thomas James; Geissel, Matthias; Rovang, Dean C.; Smith, Ian C.; Chandler, Gordon A.; Cooper, Gary Wayne; Cuneo, Michael Edward; Harvey-Thompson, Adam James; Herrmann, Mark C.; Mark Harry Hess; Lamppa, Derek C.; Martin, Matthew R.; McBride, Ryan D.; Peterson, Kyle J.; Porter, John L.; Rochau, Gregory A.; Savage, Mark E.; Schroen, Diana G.; Stygar, William A.; Vesey, Roger Alan

    2015-04-29

    In this study, the magnetized liner inertial fusion concept [S. A. Slutz et al., Phys. Plasmas17, 056303 (2010)] utilizes a magnetic field and laser heating to relax the pressure requirements of inertial confinement fusion. The first experiments to test the concept [M. R. Gomez et al., Phys. Rev. Lett. 113, 155003 (2014)] were conducted utilizing the 19 MA, 100 ns Z machine, the 2.5 kJ, 1 TW Z Beamlet laser, and the 10 T Applied B-field on Z system. Despite an estimated implosion velocity of only 70 km/s in these experiments, electron and ion temperatures at stagnation were as high as 3 keV, and thermonuclear deuterium-deuterium neutron yields up to 2 × 1012 have been produced. X-ray emission from the fuel at stagnation had widths ranging from 50 to 110 μm over a roughly 80% of the axial extent of the target (6–8 mm) and lasted approximately 2 ns. X-ray yields from these experiments are consistent with a stagnation density of the hot fuel equal to 0.2–0.4 g/cm3. In these experiments, up to 5 ×1010 secondary deuterium-tritium neutrons were produced. Given that the areal density of the plasma was approximately 1–2 mg/cm2, this indicates the stagnation plasma was significantly magnetized, which is consistent with the anisotropy observed in the deuterium-tritium neutron spectra. Control experiments where the laser and/or magnetic field were not utilized failed to produce stagnation temperatures greater than 1 keV and primary deuterium-deuterium yields greater than 1010. An additional control experiment where the fuel contained a sufficient dopant fraction to substantially increase radiative losses also failed to produce a relevant stagnation temperature. The results of these experiments are consistent with a thermonuclear neutron source.

  15. Herschel observations of Circinus X-1 during outburst and quiescence

    SciTech Connect

    Harrison, Thomas E.; Gelino, Dawn M.; Buxton, Michelle; Fost, Tyler E-mail: dawn@ipac.caltech.edu E-mail: tyler.fost@gmail.com

    2014-07-01

    We have used the Photodetector Array Camera and Spectrometer and Spectral and Photometric Imaging REceiver instruments on the Herschel Space Observatory to observe Cir X-1 both in and out of outburst. We detected Cir X-1 during outburst at 70 μm. Unfortunately, a cold background source dominates Cir X-1 at longer wavelengths. We have assembled optical and infrared (IR) data for Cir X-1 to model its spectral energy distribution (SED) in both quiescence and outburst and find that in both states it is consistent with a heavily reddened, 10,000 K blackbody. We believe this behavior is completely consistent with previous suggestions that these outbursts are due to accretion disk events, not unlike those of dwarf novae. To explore the behavior of other low-mass X-ray binaries with reported synchrotron jets, we have extracted and/or compiled optical and near- and mid-IR data sets for five such systems to construct their SEDs. The Z-source GX 349+2 and the black hole system GRS 1915+105 have strong and variable mid-IR excesses that suggest synchrotron emission. The other Z-sources have rather weak (or no) IR excesses that can be explained as reddened blackbody spectra with the addition of either synchrotron or bremsstrahlung components.

  16. ELECTROMAGNETIC SPINDOWN OF A TRANSIENT ACCRETING MILLISECOND PULSAR DURING QUIESCENCE

    SciTech Connect

    Melatos, A.; Mastrano, A. E-mail: alpham@unimelb.edu.au

    2016-02-10

    The measured spindown rates in quiescence of the transient accreting millisecond pulsars IGR J00291+5934, XTE J1751–305, SAX J1808.4–3658, and Swift J1756.9–2508 have been used to estimate the magnetic moments of these objects assuming standard magnetic dipole braking. It is shown that this approach leads to an overestimate if the amount of residual accretion is enough to distort the magnetosphere away from a force-free configuration through magnetospheric mass loading or crushing, so that the lever arm of the braking torque migrates inside the light cylinder. We derive an alternative spindown formula and calculate the residual accretion rates where the formula is applicable. As a demonstration we apply the alternative spindown formula to produce updated magnetic moment estimates for the four objects above. We note that based on current uncertain observations of quiescent accretion rates, magnetospheric mass loading and crushing are neither firmly indicated nor ruled out in these four objects. Because quiescent accretion rates are not measured directly (only upper limits are placed), without more data it is impossible to be confident about whether the thresholds for magnetospheric mass loading or crushing are reached or not.

  17. A RADIO-LOUD MAGNETAR IN X-RAY QUIESCENCE

    SciTech Connect

    Levin, Lina; Bailes, Matthew; Bhat, N. D. Ramesh; Burke-Spolaor, Sarah; Van Straten, Willem; Bates, Samuel; Kramer, Michael; Stappers, Ben; Burgay, Marta; D'Amico, Nichi; Milia, Sabrina; Possenti, Andrea; Rea, Nanda

    2010-09-20

    As part of a survey for radio pulsars with the Parkes 64 m telescope, we have discovered PSR J1622-4950, a pulsar with a 4.3 s rotation period. Follow-up observations show that the pulsar has the highest inferred surface magnetic field of the known radio pulsars (B {approx}3 x 10{sup 14} G), and it exhibits significant timing noise and appears to have an inverted spectrum. Unlike the vast majority of the known pulsar population, PSR J1622-4950 appears to switch off for many hundreds of days and even in its on-state exhibits extreme variability in its flux density. Furthermore, the integrated pulse profile changes shape with epoch. All of these properties are remarkably similar to the only two magnetars previously known to emit radio pulsations. The position of PSR J1622-4950 is coincident with an X-ray source that, unlike the other radio pulsating magnetars, was found to be in quiescence. We conclude that our newly discovered pulsar is a magnetar-the first to be discovered via its radio emission.

  18. Electromagnetic Spindown of a Transient Accreting Millisecond Pulsar During Quiescence

    NASA Astrophysics Data System (ADS)

    Melatos, A.; Mastrano, A.

    2016-02-01

    The measured spindown rates in quiescence of the transient accreting millisecond pulsars IGR J00291+5934, XTE J1751-305, SAX J1808.4-3658, and Swift J1756.9-2508 have been used to estimate the magnetic moments of these objects assuming standard magnetic dipole braking. It is shown that this approach leads to an overestimate if the amount of residual accretion is enough to distort the magnetosphere away from a force-free configuration through magnetospheric mass loading or crushing, so that the lever arm of the braking torque migrates inside the light cylinder. We derive an alternative spindown formula and calculate the residual accretion rates where the formula is applicable. As a demonstration we apply the alternative spindown formula to produce updated magnetic moment estimates for the four objects above. We note that based on current uncertain observations of quiescent accretion rates, magnetospheric mass loading and crushing are neither firmly indicated nor ruled out in these four objects. Because quiescent accretion rates are not measured directly (only upper limits are placed), without more data it is impossible to be confident about whether the thresholds for magnetospheric mass loading or crushing are reached or not.

  19. Optimized heavy ion beam probing for International Thermonuclear Experimental Reactor

    NASA Astrophysics Data System (ADS)

    Melnikov, A. V.; Eliseev, L. G.

    1999-01-01

    The international workgroup developed the conceptual design of a heavy ion beam probe (HIBP) diagnostics for International Thermonuclear Experimental Reactor (ITER), which is intended for measurements of the plasma potential profile in a gradient area. Now we optimized it by the accurate analysis of the probing trajectories and variation of positions of the injection and detection points. Optimization allows us to reduce the energy of Tl+ beam from 5.6 to 3.4 MeV for standard ITER regime. The detector line starting at the plasma edge towards the center can get an outer part of the horizontal radial potential profile by variation of the energy. The observed radial interval is slightly increased up to 0.76<ρ<1 with respect to initial version 0.8<ρ<1, that allows to cover the region of the density gradient more reliably. Almost double reduction of the beam energy is a critical point. Thus we can significantly decrease the sizes of the accelerator and energy analyzer, the cost of the equipment, and impact of the diagnostics to the machine. Therefore the optimized HIBP design can be realized in ITER.

  20. Poloidal flux linkage requirements for the International Thermonuclear Experimental Reactor

    SciTech Connect

    Jardin, S.C.; Kessel, C.; Pomphrey, N.

    1994-01-01

    We have applied two computational models to calculate the poloidal flux linkage requirements for the current ramp-up and for the flattop phase of the proposed International Thermonuclear Experimental Reactor (ITER). For the current ramp-up phase, we have used the TSC code to simulate the entire current ramp-up period as described in the TAC-3 Physics Report. We have extended the time of the simulation to cover the full current penetration time, that is, until the loop voltage is a constant throughout the plasma. Sensitivity studies have been performed with respect to current ramp-up time, impurity concentration, and to the time of onset of auxiliary heating. We have also used a steady state plasma equilibrium code that has the constant loop voltage constraint built in to survey the dependence of the steady state loop-voltage on the density and temperature profiles. This calculation takes into account the plasma bootstrap current contribution, including non-circular and collisional corrections. The results can be displayed as contours of the loop-voltage on a POPCON like diagram.

  1. Focused Study of Thermonuclear Bursts on Neutron Stars

    NASA Astrophysics Data System (ADS)

    Chenevez, Jérôme

    2009-05-01

    X-ray bursters form a class of Low Mass X-Ray Binaries where accreted material from a donor star undergoes rapid thermonuclear burning in the surface layers of a neutron star. The flux released can temporarily exceed the Eddington limit and drive the photosphere to large radii. Such photospheric radius expansion bursts likely eject nuclear burning ashes into the interstellar medium, and may make possible the detection of photoionization edges. Indeed, theoretical models predict that absorption edges from 58Fe at 9.2 keV, 60Zn and 62Zn at 12.2 keV should be detectable by the future missions Simbol-X and NuSTAR. A positive detection would thus probe the nuclear burning as well as the gravitational redshift from the neutron star. Moreover, likely observations of atomic X-ray spectral components reflected from the inner accretion disk have been reported. The high spectral resolution capabilities of the focusing X-ray telescopes may therefore make possible to differentiate between the potential interpretations of the X-ray bursts spectral features.

  2. Current drive for stability of thermonuclear plasma reactor

    NASA Astrophysics Data System (ADS)

    Amicucci, L.; Cardinali, A.; Castaldo, C.; Cesario, R.; Galli, A.; Panaccione, L.; Paoletti, F.; Schettini, G.; Spigler, R.; Tuccillo, A.

    2016-01-01

    To produce in a thermonuclear fusion reactor based on the tokamak concept a sufficiently high fusion gain together stability necessary for operations represent a major challenge, which depends on the capability of driving non-inductive current in the hydrogen plasma. This request should be satisfied by radio-frequency (RF) power suitable for producing the lower hybrid current drive (LHCD) effect, recently demonstrated successfully occurring also at reactor-graded high plasma densities. An LHCD-based tool should be in principle capable of tailoring the plasma current density in the outer radial half of plasma column, where other methods are much less effective, in order to ensure operations in the presence of unpredictably changes of the plasma pressure profiles. In the presence of too high electron temperatures even at the periphery of the plasma column, as envisaged in DEMO reactor, the penetration of the coupled RF power into the plasma core was believed for long time problematic and, only recently, numerical modelling results based on standard plasma wave theory, have shown that this problem should be solved by using suitable parameter of the antenna power spectrum. We show here further information on the new understanding of the RF power deposition profile dependence on antenna parameters, which supports the conclusion that current can be actively driven over a broad layer of the outer radial half of plasma column, thus enabling current profile control necessary for the stability of a reactor.

  3. Thermonuclear dynamo inside ultracentrifuge with supersonic plasma flow stabilization

    NASA Astrophysics Data System (ADS)

    Winterberg, F.

    2016-01-01

    Einstein's general theory of relativity implies the existence of virtual negative masses in the rotational reference frame of an ultracentrifuge with the negative mass density of the same order of magnitude as the positive mass density of a neutron star. In an ultracentrifuge, the repulsive gravitational field of this negative mass can simulate the attractive positive mass of a mini-neutron star, and for this reason can radially confine a dense thermonuclear plasma placed inside the centrifuge, very much as the positive mass of a star confines its plasma by its own attractive gravitational field. If the centrifuge is placed in an externally magnetic field to act as the seed field of a magnetohydrodynamic generator, the configuration resembles a magnetar driven by the release of energy through nuclear fusion, accelerating the plasma to supersonic velocities, with the magnetic field produced by the thermomagnetic Nernst effect insulating the hot plasma from the cold wall of the centrifuge. Because of the supersonic flow and the high plasma density the configuration is stable.

  4. Detection of burning ashes from thermonuclear X-ray bursts

    NASA Astrophysics Data System (ADS)

    Kajava, J. J. E.; Nättilä, J.; Poutanen, J.; Cumming, A.; Suleimanov, V.; Kuulkers, E.

    2017-01-01

    When neutron stars (NS) accrete gas from low-mass binary companions, explosive nuclear burning reactions in the NS envelope fuse hydrogen and helium into heavier elements. The resulting thermonuclear (type-I) X-ray bursts produce energy spectra that are fit well with black bodies, but a significant number of burst observations show deviations from Planck spectra. Here we present our analysis of RXTE/PCA observations of X-ray bursts from the NS low-mass X-ray binary HETE J1900.1-2455. We have discovered that the non-Planckian spectra are caused by photoionization edges. The anticorrelation between the strength of the edges and the colour temperature suggests that the edges are produced by the nuclear burning ashes that have been transported upwards by convection and become exposed at the photosphere. The atmosphere model fits show that occasionally the photosphere can consist entirely of metals, and that the peculiar changes in blackbody temperature and radius can be attributed to the emergence and disappearance of metals in the photosphere. As the metals are detected already in the Eddington-limited phase, it is possible that a radiatively driven wind ejects some of the burning ashes into the interstellar space.

  5. Divertor impurity monitor for the International Thermonuclear Experimental Reactor

    NASA Astrophysics Data System (ADS)

    Sugie, T.; Ogawa, H.; Nishitani, T.; Kasai, S.; Katsunuma, J.; Maruo, M.; Ebisawa, K.; Ando, T.; Kita, Y.

    1999-01-01

    The divertor impurity monitoring system of the International Thermonuclear Experimental Reactor has been designed. The main functions of this system are to identify impurity species and to measure the two-dimensional distributions of the particle influxes in the divertor plasmas. The wavelength range is 200-1000 nm. The viewing fans are realized by molybdenum mirrors located in the divertor cassette. With additional viewing fans seeing through the gap between the divertor cassettes, the region approximately from the divertor leg to the x point will be observed. The light from the divertor region passes through the quartz windows on the divertor port plug and the cryostat, and goes through the dog-leg optics in the biological shield. Three different type of spectrometers: (i) survey spectrometers for impurity species monitoring, (ii) filter spectrometers for the particle influx measurement with the spatial resolution of 10 mm and the time resolution of 1 ms, and (iii) high dispersion spectrometers for high resolution wavelength measurements are designed. These spectrometers are installed just behind the biological shield (for λ<450 nm) to prevent the transmission loss in fiber and in the diagnostic room (for λ⩾450 nm) from the point of view of accessibility and flexibility. The optics have been optimized by a ray trace analysis. As a result, 10-15 mm spatial resolution will be achieved in all regions of the divertor.

  6. Thermonuclear dynamo inside ultracentrifuge with supersonic plasma flow stabilization

    SciTech Connect

    Winterberg, F.

    2016-01-15

    Einstein's general theory of relativity implies the existence of virtual negative masses in the rotational reference frame of an ultracentrifuge with the negative mass density of the same order of magnitude as the positive mass density of a neutron star. In an ultracentrifuge, the repulsive gravitational field of this negative mass can simulate the attractive positive mass of a mini-neutron star, and for this reason can radially confine a dense thermonuclear plasma placed inside the centrifuge, very much as the positive mass of a star confines its plasma by its own attractive gravitational field. If the centrifuge is placed in an externally magnetic field to act as the seed field of a magnetohydrodynamic generator, the configuration resembles a magnetar driven by the release of energy through nuclear fusion, accelerating the plasma to supersonic velocities, with the magnetic field produced by the thermomagnetic Nernst effect insulating the hot plasma from the cold wall of the centrifuge. Because of the supersonic flow and the high plasma density the configuration is stable.

  7. High energy components and collective modes in thermonuclear plasmas

    SciTech Connect

    Coppi, B.; Cowley, S.; Detragiache, P.; Kulsrud, R.; Pegoraro, F.

    1986-02-01

    The theory of a class of collective modes of a thermonuclear magnetically confined plasma, with frequencies in the range of the ion cyclotron frequency and of its harmonics, is presented. These modes can be excited by their resonant cyclotron interaction with a plasma component of relatively high energy particles characterized by a strongly anisotropic distribution in velocity space. Normal modes that are spatially localized by the inhomogeneity of the plasma density are found. This ensures that the energy gained by their resonant interaction is not convected away. The mode spatial localization can be significantly altered by the magnetic field inhomogeneity for a given class of plasma density profiles. Special attention is devoted to the case of a spin polarized plasma, where the charged products of fusion reactions are anisotropically distributed. We show that for the mode of polarization that enhances nuclear reaction rates the tritium will be rapidly depolarized to toroidal configurations with relatively mild gradients of the confining magnetic field. 18 refs., 9 figs.

  8. Restless legs syndrome in subjects with a knee prosthesis: evidence that symptoms are generated in the periphery

    PubMed Central

    Pereira, José Carlos; da Silva Neto, João Luiz Pereira; Pradella-Hallinan, Márcia

    2011-01-01

    OBJECTIVE: There are no data adressing the prevalence of restless legs syndrome in subjects who have knee prosthesis. Therefore, we conducted a cross-sectional survey of subjects who underwent knee prosthesis surgery. METHOD: A total of 107 subjects (30 male, 77 female) were interviewed over the telephone regarding restless legs syndrome symptoms. If the patients exhibited symptoms of the syndrome, we conducted face-to-face interviews. Lastly, a therapeutic test with pramipexole was proposed for each subject. RESULTS: In our cohort, 7 males (23%) and 30 females (39%) had restless legs syndrome. Of these, 6 males and 23 females were submitted to face-to-face-interview. Of the males, 5 (83%) had restless legs after the knee surgery- exclusively in the operated leg- and reported no family restless legs history. One man had a prior case of bilateral restless legs syndrome, a positive family history and claimed exacerbation of symptoms in the operated leg. Among the females, 16 (69%) had restless legs prior to surgery. A total of 10 female patients reported bilateral symptoms, with fewer symptoms in the operated leg, while 6 displayed a worse outcome in the operated leg. The 7 females (31%) without restless legs prior to surgery and without a family history experienced symptoms only in the operated leg. All subjects responded favorably to the pramipexole therapeutic test. CONCLUSION: Our results suggest that secondary unilateral restless legs syndrome may ensue from knee prosthesis surgery and that the symptoms are generated in the peripheral nervous system. PMID:22086528

  9. Ropinirole for the treatment of restless legs syndrome

    PubMed Central

    Kushida, Clete A

    2006-01-01

    Dopaminergic agents, anticonvulsants, benzodiazepines, opiates, and iron supplementation comprise the classes of medications commonly used to treat restless legs syndrome (RLS), which is a disorder that is estimated to affect about 1 in 10 individuals worldwide and impacts an affected patient’s sleep, mood, daytime function, and quality of life. RLS is characterized by an urge to move the legs that is worse at bedtime and at rest; the symptoms are temporarily relieved by leg movement. It is frequently accompanied by periodic limb movements during sleep (PLMS), which may independently disrupt sleep and may cause daytime drowsiness. Dopaminergic agents are considered to be first-line therapy in the management of RLS as well as PLMS. Ropinirole (Requip®, GlaxoSmithKline) is a dopamine agonist that was the first medication approved by the US Food and Drug Administration (FDA) for the treatment of moderate-to-severe primary RLS. Based on several large-scale clinical trials and open-label clinical series, this medication has been demonstrated to be effective and safe in treating the motor symptoms of RLS and improving sleep quality. PMID:19412490

  10. Apomorphine in idiopathic restless legs syndrome: an exploratory study

    PubMed Central

    Tribl, G; Sycha, T; Kotzailias, N; Zeitlhofer, J; Auff, E

    2005-01-01

    Background: Dopaminergic and opioidergic drugs have been found to be effective in patients with restless legs syndrome (RLS). Objectives: To test the effect of apomorphine—a combined opioidergic and dopaminergic agonist—and subsequent selective antagonism by naloxone and metoclopramide on subjective and objective symptoms in patients with idiopathic RLS. Methods: Nine patients with RLS were pretreated with oral domperidone for three days. A modified suggested immobilisation test (SIT) was carried out between 8 pm and 1 am under the following conditions of intravenous drug administration: baseline–apomorphine–apomorphine plus naloxone–apomorphine plus metoclopramide. Outcome variables were a visual analogue scale (VAS) of subjective RLS symptoms and EMG documented periodic leg movements while awake (PLMW). Results: Compared with baseline, apomorphine resulted in a rapid and significant improvement in subjective RLS symptoms as measured by VAS (54.5% improvement; p = 0.011), and an almost immediate cessation of PLMW, measured by PLMW index (98.0% improvement; p = 0.012). Neither additional naloxone nor metoclopramide blocked this effect significantly. While given apomorphine with metoclopramide, there was a trend to reappearance of PLMW. Conclusions: Apomorphine may be an effective treatment for idiopathic RLS. Its effectiveness may reflect both to its dopaminergic and its opioidergic activity, and is not diminished significantly by blocking only one of these pathways. The trend to a worsening of the PLMW index with metoclopramide hints at a primarily dopaminergic effect of apomorphine in idiopathic RLS. PMID:15654028

  11. [Dopamine dysregulation syndrome in Parkinson's disease and restless legs syndrome].

    PubMed

    Bayard, Sophie; Cochen De Cock, Valérie; Dauvillers, Yves

    2011-06-01

    Dopamine replacement therapy in Parkinson's disease (PD) improves the motor symptoms. However, it has recently been shown that a small sub-group of patients suffers from motor and behavioral disturbances associated with the use of dopamine agonists (DAs). The behavioral disorders are incentive- or reward-based repetitive symptoms regrouped under the term « dopamine dysregulation syndrome » (DDS). They include pathological gambling, hypersexuality, compulsive shopping, compulsive eating, punding, and compulsive medication use. Whether these behaviors are related to the dopaminergic medications interacting with an underlying individual vulnerability or whether the primary pathological features of Parkinson's disease play a role is not entirely understood. This review is devoted to the phenomenology of the DDS and factors influencing its susceptibility. We further review the literature studies that investigated the decision-making profile using the Iowa Gambling Task in Parkinson's disease, and the recent literature devoted to these abnormal behaviors in the restless legs syndrome (RLS). Given the potential substantial impact of the DDS on personal, familial, social, and financial well-being, patients with PD or RLS should be informed that DAs use may lead to the development of impulsive and compulsive disorders, and clinicians should include the investigation of these disorders as part of routine clinical care. The refinement of clinical strategies to predict, identify and manage DDS will help the future care of motor and non-motor symptoms of Parkinson's disease.

  12. Restless leg syndrome: is it a real problem?

    PubMed Central

    Cotter, Paul E; O’Keeffe, Shaun T

    2006-01-01

    Restless legs syndrome (RLS) is a common condition that is frequently unrecognized, misdiagnosed and poorly managed. It is characterized by uncomfortable sensations deep in the legs developing at rest that compel the person to move; symptoms are worst at night and sleep disturbance is common. RLS occurs in 7%–11% of the population in Western countries, and many such people experience troublesome symptoms. Primary RLS is familial in up to two thirds of patients. RLS may also be secondary to a number of conditions including iron deficiency, pregnancy and end-stage renal failure and, perhaps, neuropathy. Secondary RLS is most common in those presenting for the first time in later life. The pathogenesis of RLS probably involves the interplay of systemic or brain iron deficiency and impaired dopaminergic neurotransmission in the subcortex of the brain. RLS is very responsive to dopaminergic therapies. Rebound of RLS symptoms during the early morning and development of severe symptoms earlier in the day (augmentation) are problematic in those treated for a prolonged period with levodopa. Consequently, dopamine agonists have become first line treatment. Anti-convulsant medications and opioids are helpful in some patients. Correction of underlying problem wherever possible is important in the management of secondary RLS. PMID:18360657

  13. Restless Leg Syndrome and Sleep Quality in Lumbar Radiculopathy Patients

    PubMed Central

    Terzi, Murat; Akpinar, Kursad; Paksoy, Kemal; Cebeci, Ibrahim; Iyigun, Omer

    2014-01-01

    Background. To investigate the frequency of restless leg syndrome (RLS), sleep quality impairment, depression, fatigue, and sleep behavior disorder and to determine the effects of surgery on these parameters in radiculopathy patients resistant to conservative treatment. Methods. The present study included 66 lumbar radiculopathy patients, who were resistant to conservative treatment and had indication of surgery. Five different questionnaires were performed to assess depression (the Beck Depression Inventory (BDI)), sleep quality (the Pittsburgh Sleep Quality Index (PSQI)), fatigue (the Fatigue Severity Scale (FSS)), and presence of RLS and rapid eye movement sleep behavior disorder (RBD). The same questionnaires were also performed on a control group (n = 61). Results. Of the radiculopathy patients, 68.1% had RLS and 92.4% had fatigue. Of the controls, 16.4% had RLS and 59% had fatigue. RBD was present in 8 (12.1%) patients and 3 (4.9%) controls. The PSQI revealed that sleep quality was impaired in 46 (69.7%) patients and 35 (57.4%) controls (P > 0.05). The number of individuals having substantial depression according to the BDI was significantly higher in the patients than in the controls. Conclusions. There was a significant increase in the frequency of RLS, which was significantly decreased in the postoperative period in the radiculopathy patients. PMID:25110396

  14. Theory of supercompression of vapor bubbles and nanoscale thermonuclear fusion

    NASA Astrophysics Data System (ADS)

    Nigmatulin, Robert I.; Akhatov, Iskander Sh.; Topolnikov, Andrey S.; Bolotnova, Raisa Kh.; Vakhitova, Nailya K.; Lahey, Richard T.; Taleyarkhan, Rusi P.

    2005-10-01

    This paper provides the theoretical basis for energetic vapor bubble implosions induced by a standing acoustic wave. Its primary goal is to describe, explain, and demonstrate the plausibility of the experimental observations by Taleyarkhan et al. [Science 295, 1868 (2002); Phys. Rev. E 69, 036109 (2004)] of thermonuclear fusion for imploding cavitation bubbles in chilled deuterated acetone. A detailed description and analysis of these data, including a resolution of the criticisms that have been raised, together with some preliminary HYDRO code simulations, has been given by Nigmatulin et al. [Vestnik ANRB (Ufa, Russia) 4, 3 (2002); J. Power Energy 218-A, 345 (2004)] and Lahey et al. [Adv. Heat Transfer (to be published)]. In this paper a hydrodynamic shock (i.e., HYDRO) code model of the spherically symmetric motion for a vapor bubble in an acoustically forced liquid is presented. This model describes cavitation bubble cluster growth during the expansion period, followed by a violent implosion during the compression period of the acoustic cycle. There are two stages of the bubble dynamics process. The first, low Mach number stage, comprises almost all the time of the acoustic cycle. During this stage, the radial velocities are much less than the sound speeds in the vapor and liquid, the vapor pressure is very close to uniform, and the liquid is practically incompressible. This process is characterized by the inertia of the liquid, heat conduction, and the evaporation or condensation of the vapor. The second, very short, high Mach number stage is when the radial velocities are the same order, or higher, than the sound speeds in the vapor and liquid. In this stage high temperatures, pressures, and densities of the vapor and liquid take place. The model presented herein has realistic equations of state for the compressible liquid and vapor phases, and accounts for nonequilibrium evaporation/condensation kinetics at the liquid/vapor interface. There are interacting

  15. Theory of supercompression of vapor bubbles and nanoscale thermonuclear fusion

    SciTech Connect

    Nigmatulin, Robert I.; Akhatov, Iskander Sh.; Topolnikov, Andrey S.; Bolotnova, Raisa Kh.; Vakhitova, Nailya K.; Lahey, Richard T. Jr.; Taleyarkhan, Rusi P.

    2005-10-01

    This paper provides the theoretical basis for energetic vapor bubble implosions induced by a standing acoustic wave. Its primary goal is to describe, explain, and demonstrate the plausibility of the experimental observations by Taleyarkhan et al. [Science 295, 1868 (2002); Phys. Rev. E 69, 036109 (2004)] of thermonuclear fusion for imploding cavitation bubbles in chilled deuterated acetone. A detailed description and analysis of these data, including a resolution of the criticisms that have been raised, together with some preliminary HYDRO code simulations, has been given by Nigmatulin et al. [Vestnik ANRB (Ufa, Russia) 4, 3 (2002); J. Power Energy 218-A, 345 (2004)] and Lahey et al. [Adv. Heat Transfer (to be published)]. In this paper a hydrodynamic shock (i.e., HYDRO) code model of the spherically symmetric motion for a vapor bubble in an acoustically forced liquid is presented. This model describes cavitation bubble cluster growth during the expansion period, followed by a violent implosion during the compression period of the acoustic cycle. There are two stages of the bubble dynamics process. The first, low Mach number stage, comprises almost all the time of the acoustic cycle. During this stage, the radial velocities are much less than the sound speeds in the vapor and liquid, the vapor pressure is very close to uniform, and the liquid is practically incompressible. This process is characterized by the inertia of the liquid, heat conduction, and the evaporation or condensation of the vapor. The second, very short, high Mach number stage is when the radial velocities are the same order, or higher, than the sound speeds in the vapor and liquid. In this stage high temperatures, pressures, and densities of the vapor and liquid take place. The model presented herein has realistic equations of state for the compressible liquid and vapor phases, and accounts for nonequilibrium evaporation/condensation kinetics at the liquid/vapor interface. There are interacting

  16. Echocardiography as an indication of continuous-time cardiac quiescence

    NASA Astrophysics Data System (ADS)

    Wick, C. A.; Auffermann, W. F.; Shah, A. J.; Inan, O. T.; Bhatti, P. T.; Tridandapani, S.

    2016-07-01

    Cardiac computed tomography (CT) angiography using prospective gating requires that data be acquired during intervals of minimal cardiac motion to obtain diagnostic images of the coronary vessels free of motion artifacts. This work is intended to assess B-mode echocardiography as a continuous-time indication of these quiescent periods to determine if echocardiography can be used as a cost-efficient, non-ionizing modality to develop new prospective gating techniques for cardiac CT. These new prospective gating approaches will not be based on echocardiography itself but on CT-compatible modalities derived from the mechanics of the heart (e.g. seismocardiography and impedance cardiography), unlike the current standard electrocardiogram. To this end, echocardiography and retrospectively-gated CT data were obtained from ten patients with varied cardiac conditions. CT reconstructions were made throughout the cardiac cycle. Motion of the interventricular septum (IVS) was calculated from both echocardiography and CT reconstructions using correlation-based, deviation techniques. The IVS was chosen because it (1) is visible in echocardiography images, whereas the coronary vessels generally are not, and (2) has been shown to be a suitable indicator of cardiac quiescence. Quiescent phases were calculated as the minima of IVS motion and CT volumes were reconstructed for these phases. The diagnostic quality of the CT reconstructions from phases calculated from echocardiography and CT data was graded on a four-point Likert scale by a board-certified radiologist fellowship-trained in cardiothoracic radiology. Using a Wilcoxon signed-rank test, no significant difference in the diagnostic quality of the coronary vessels was found between CT volumes reconstructed from echocardiography- and CT-selected phases. Additionally, there was a correlation of 0.956 between the echocardiography- and CT-selected phases. This initial work suggests that B-mode echocardiography can be used as a

  17. Spontaneous Formation of Detonations by Turbulent Flames in Thermonuclear Supernovae

    NASA Astrophysics Data System (ADS)

    Poludnenko, Alexei Y.; Oran, E. S.

    2012-01-01

    Presently, the scenario best capable of explaining the observational properties of "normal" type Ia supernovae (SNIa), which are of primary importance for cosmology, is the delayed-detonation model. This model postulates that a subsonic thermonuclear deflagration, which originates close to the center of a Chandrasekhar-mass white dwarf (WD) in a single-degenerate binary system, transitions to a supersonic detonation (deflagration-to-detonation transition, or DDT) during the later stages of the explosion. Modern large-scale multidimensional simulations of SNIa cannot capture the DDT process and, thus, are forced to make two crucial assumptions, namely (a) that DDT does occur at some point, and (b) when and where it occurs. Significant progress has been made over the years in elucidating the nature of DDT in terrestrial confined systems with walls, obstacles, or pre-existing shocks. It remains unclear, however, whether and how a detonation can form in an unpressurized, unconfined system such as the interior of a WD. Here we show, through first-principles numerical simulations, that sufficiently fast, but subsonic, turbulent flames in such unconfined environments are inherently susceptible to DDT. The associated mechanism is based on the unsteady evolution of turbulent flames faster than the Chapman-Jouguet deflagrations and is qualitatively different from the traditionally suggested gradient (spontaneous reaction wave) model. It also does not require the formation of distributed flames. The proposed mechanism predicts the DDT density in SNIa to be 107 g/cm3, in agreement with the values previously found to give the best match with observations. This DDT mechanism opens the possibility for eliminating the transition density as a free parameter and, thus, for developing fully self-consistent global multidimensional SNIa models. This work was supported in part by the Naval Research Laboratory, the Air Force Office of Scientific Research, and by the Department of Defense

  18. SUPER-EDDINGTON FLUXES DURING THERMONUCLEAR X-RAY BURSTS

    SciTech Connect

    Boutloukos, Stratos; Miller, M. Coleman; Lamb, Frederick K.

    2010-09-01

    It has been known for nearly three decades that the energy spectra of thermonuclear X-ray bursts are often well fit by Planck functions with temperatures so high that they imply a super-Eddington radiative flux at the emitting surface, even during portions of bursts when there is no evidence of photospheric radius expansion. This apparent inconsistency is usually set aside by assuming that the flux is actually sub-Eddington and that the fitted temperature is so high because the spectrum has been distorted by the energy-dependent opacity of the atmosphere. Here we show that the spectra predicted by currently available conventional atmosphere models appear incompatible with the highest precision measurements of burst spectra made using the Rossi X-ray Timing Explorer, such as during the 4U 1820-30 superburst and a long burst from GX 17+2. In contrast, these measurements are well fit by Bose-Einstein spectra with high temperatures and modest chemical potentials. Such spectra are very similar to Planck spectra. They imply surface radiative fluxes more than a factor of 3 larger than the Eddington flux. We find that segments of many other bursts from many sources are well fit by similar Bose-Einstein spectra, suggesting that the radiative flux at the emitting surface also exceeds the Eddington flux during these segments. We suggest that burst spectra can closely approximate Bose-Einstein spectra and have fluxes that exceed the Eddington flux because they are formed by Comptonization in an extended, low-density radiating gas supported by the outward radiation force and confined by a tangled magnetic field.

  19. Association between irritable bowel syndrome and restless legs syndrome in the general population.

    PubMed

    Yun, Chang-Ho; Lee, Seung K; Kim, Hyun; Park, Hee-Kwon; Lee, Seung H; Kim, Se J; Shin, Chol

    2012-10-01

    This study aimed to explore the association between restless legs syndrome and irritable bowel syndrome in an epidemiological cohort. We included 3365 adults, of whom 1602 were female (age 52.5 ± 7.5 years), who had participated in the Korean Genome and Epidemiology Study (2005-2006). The diagnosis of restless legs syndrome was based on the criteria proposed by the International Restless Legs Syndrome Study Group, and irritable bowel syndrome was defined according to the Rome II criteria. The prevalence of each condition was determined and their association was tested by logistic regression analysis. Age, sex, haemoglobin concentration, renal insufficiency, use of medications and depressive mood were all adjusted for. The prevalence of restless legs syndrome and irritable bowel syndrome was 4.5 and 11.1%, respectively. Irritable bowel syndrome was more prevalent in the group with restless legs syndrome (24.0 versus 10.5%, P < 0.001). Subjects with restless legs syndrome were older (54.2 ± 8.4 versus 52.4 ± 7.4, P = 0.006) and more depressive (26.7 versus 12.5%, P < 0.001), and were predominantly female (57.3 versus 47.2%, P = 0.015), had more frequent insomnia symptoms (44.0 versus 28.2%, P < 0.001), had lower haemoglobin concentration (13.7 ± 1.5 versus 14.1 ± 1.6 g dL(-1) P = 0.004) and higher highly sensitive C-reactive protein (1.8 ± 5.1 versus 1.4 ± 2.9 mg dL(-1), P = 0.08). The adjusted odds ratio of restless legs syndrome in relation to irritable bowel syndrome was 2.59 (1.74-3.85, P < 0.001). Irritable bowel syndrome appeared to be associated with restless legs syndrome independently from other major risk factors for restless legs syndrome. Searching for the mechanisms underlying this association is indicated.

  20. Migratory restlessness in captive individuals predicts actual departure in the wild.

    PubMed

    Eikenaar, Cas; Klinner, Thomas; Szostek, K Lesley; Bairlein, Franz

    2014-01-01

    In captivity, migratory birds show increased activity during the time that they would normally migrate. The phenology and intensity of such 'migratory restlessness' has been shown to mirror species- and population-specific migration patterns observed in the wild and has consequently been used as a proxy for the motivation to migrate. Many studies doing so, however, were aiming to explain among-individual variation in migratory behaviour or traits, and not species- or population-specific traits. These studies thus assumed that, also at the level of the individual, migratory restlessness is an accurate proxy for the motivation to migrate. We tested this assumption for the first time and found that it holds; individuals showing very little migratory restlessness remained at stopover for longer than one night, whereas most individuals showing more restlessness departed sooner. This finding validates the use of migratory restlessness as a proxy for the motivation to migrate, thereby justifying the conclusions made in a large body of research on avian migration.

  1. The Effect of Stretching Exercises on Severity of Restless Legs Syndrome in Patients on Hemodialysis

    PubMed Central

    Aliasgharpour, Mansooreh; Abbasi, Zahra; Pedram Razi, Shadan; Kazemnezhad, Anoshiravan

    2016-01-01

    Background The restless legs syndrome is a sensorimotor disorder that is very common in patients on hemodialysis. Due to pharmacological treatments which have their own side effects, nowadays, studies have turned to non-pharmacological treatments. Objectives The present study aims to assess the effect of stretching exercises on the severity of restless legs syndrome in patients on hemodialysis. Patients and Methods This clinical trial study was conducted on 33 patients who had been identified using diagnostic criteria from the hemodialysis ward of Hasheminejad Hospital in Tehran. Participants were randomly divided into the intervention group (n = 17) and control group (n = 16). Stretching exercises were performed on legs during the dialysis for half an hour, three times a week for 8 weeks in intervention group. Data were collected by using the international restless legs syndrome study group scale. Results The results showed that the majority of participants were suffering from moderate restless legs syndrome. The symptom severity of this syndrome meaningfully changed eight weeks after intervention in the intervention group compared to the control group (P < 0.001). Conclusions The results highlighted the significance of training and performing the stretching exercises during dialysis for the purpose of improving restless legs syndrome symptoms and the quality of care of hemodialysis patients. PMID:27625757

  2. A bioengineered niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy

    PubMed Central

    Quarta, Marco; Brett, Jamie O.; DiMarco, Rebecca; De Morree, Antoine; Boutet, Stephane C.; Chacon, Robert; Gibbons, Michael C.; Garcia, Victor A.; Su, James; Shrager, Joseph B.; Heilshorn, Sarah; Rando, Thomas A.

    2016-01-01

    A promising therapeutic strategy for diverse genetic disorders involves transplantation of autologous stem cells that have been genetically corrected ex vivo. A major challenge in such approaches is a loss of stem cell potency during stem cell culture. Here we describe a system for maintaining muscle stem cells (MuSCs) in vitro in a potent, quiescent state. Using a machine learning method, we identified a molecular signature of quiescence and used it to screen for factors that could maintain mouse MuSC quiescence, thus defining a quiescence medium (QM). We also designed artificial muscle fibers (AMFs) that mimic the native myofiber of the MuSC niche. Mouse MuSCs maintained in QM on AMFs showed enhanced potential for engraftment, tissue regeneration and self-renewal after transplantation in mice. An artificial niche adapted to human MuSCs showed similarly prolonged quiescence in vitro and enhanced potency in vivo. Our approach for maintaining quiescence may be applicable to stem cells from a range of other tissues. PMID:27240197

  3. Restless “Lower Back” in a Patient with Parkinson’s Disease

    PubMed Central

    Suzuki, Keisuke; Miyamoto, Masayuki; Miyamoto, Tomoyuki; Hirata, Koichi

    2013-01-01

    Background In restless legs syndrome (RLS), the isolated involvement of other body parts in the absence of leg involvement is rare. Case report We report an 82-year-old male with a 1-year history of Parkinson’s disease (PD) who developed an abnormal sensation limited to his “lower back.” He fulfilled the four essential RLS criteria, with the major caveat that the criteria were applied in a modified manner to his lower back rather than his legs. The administration of a dopamine agonist completely eliminated his symptoms. Discussion Our patient’s “restless lower back” may be a variant of RLS. Clinicians should pay attention to restlessness in other body parts in addition to the legs. PMID:24255803

  4. Algorithms for the diagnosis and treatment of restless legs syndrome in primary care

    PubMed Central

    2011-01-01

    Background Restless legs syndrome (RLS) is a neurological disorder with a lifetime prevalence of 3-10%. in European studies. However, the diagnosis of RLS in primary care remains low and mistreatment is common. Methods The current article reports on the considerations of RLS diagnosis and management that were made during a European Restless Legs Syndrome Study Group (EURLSSG)-sponsored task force consisting of experts and primary care practioners. The task force sought to develop a better understanding of barriers to diagnosis in primary care practice and overcome these barriers with diagnostic and treatment algorithms. Results The barriers to diagnosis identified by the task force include the presentation of symptoms, the language used to describe them, the actual term "restless legs syndrome" and difficulties in the differential diagnosis of RLS. Conclusion The EURLSSG task force reached a consensus and agreed on the diagnostic and treatment algorithms published here. PMID:21352569

  5. Parathyroidectomy Improves Restless Leg Syndrome in Patients on Hemodialysis

    PubMed Central

    Santos, Roberto Sávio Silva; Coelho, Fernando Morgadinho Santos; da Silva, Bruno Caldin; Graciolli, Fabiana Giorgeti; Dominguez, Wagner Velasquez; de Menezes Montenegro, Fabio Luiz; Jorgetti, Vanda; Moysés, Rosa Maria Affonso; Elias, Rosilene Motta

    2016-01-01

    Background Restless leg syndrome (RLS) is a sleep disorder with high prevalence among patients on hemodialysis. It has been postulated that high phosphate and high parathyroid hormone may be implicated in its pathogenesis. Standard international criteria and face-to-face interview are not always applied. Methods this was an interventional prospective study in which 19 patients (6 men, aged 48±11 years) with severe hyperparathyroidism were evaluated. RLS diagnosis and rating scale were accessed based on the International RLS Study Group pre- and post-parathyroidectomy. Patients also underwent standard polysomnography. Results At baseline, RLS was present in 10 patients (52.6%), and pain was the most reported symptom associated with the diagnosis. Patients with RLS had higher serum phosphate (p = 0.008) that remained independently associated with RLS in a logistic regression model, adjusted for hemoglobin, age and gender (HR = 7.28;CI = 1.14–46.3, p = 0.035). After parathyroidectomy, there was a reduction of serum parathyroid hormone, phosphate, calcium and alkaline phosphatase, and an increase of 25(OH)-vitamin D, and Fetuin-A. Parathyroidectomy alleviated RLS (from 52% to 21%; p = 0.04), which was accompanied by a decrease in severity scale, in association with relief of pain and pruritus. Polysomnography in these patients showed an improvement of sleep parameters as measured by sleep efficiency, sleep latency and percentage of REM sleep. Conclusion RLS is associated with high levels of phosphate in patients with severe secondary hyperparathyroidism on hemodialysis. Pain is most reported complain in these patients. Parathyroidectomy provided an opportunity to relief RLS. Whether the reduction of serum phosphorus or parathyroid hormone contributed to this improvement merits further investigation. PMID:27196740

  6. Relationship between primary restless legs syndrome and migraine with aura.

    PubMed

    Acar, Bilgehan Atılgan; Acar, Türkan; Alagöz, Aybala Neslihan; Karacan, Alper; Varım, Ceyhun; Uyanık, Mehmet Şevki; Kaya, Tezcan; Akdemir, Ramazan

    2016-08-01

    In this study, the prevalence and characteristics of definite migraine in primary restless legs syndrome (pRLS) patients and matched control patients (CPs) were investigated. We evaluated 63 consecutive adult pRLS patients and 141 age- and sex-matched controls in this case-control study. The diagnosis of migraine and its subtypes were defined based on The International Classification of Headache Disorders-II. Only those with "definite" migraine were included in the study. The mean age of 63 adult pRLS patients (15 men and 48 women) who participated in the study was 49.4 years. A total of 27 patients (42.9%) had definite migraine. Of these migraineurs, seven (11.1%) were without aura and 20 (31.8%) were with aura. The mean age of the 141 matched CPs was 48.7 years. A total of 32 CPs (22.7%) experienced migraine. Among these 32 migraineurs, 28 (19.9%) were without aura and four (2.8%) were with aura. Migraine and migraine with aura were significantly more common in pRLS patients than in CPs. pRLS patients with migraine were more anxious and experienced a shorter duration of RLS symptoms than pRLS patients without migraine. Migraineurs in the pRLS group tended to have high scores for severity of migraine headache by Visual Analog Scale score and high levels of disability by Migraine Disability Assessment grading than those in the control group. pRLS patients showed a positive association with definite migraine headaches. In contrast to results highlighted in recent studies, we found a strong link between migraine with aura and pRLS.

  7. Circadian Change in Blink Reflex Recovery in Restless Legs Syndrome

    PubMed Central

    UZUN, Nurten; GÜNDÜZ, Ayşegül; KARADENİZ, Derya; KIZILTAN, Meral E.

    2016-01-01

    Introduction Restless legs syndrome (RLS) is associated with dysfunction of the dopaminergic systems in the pathways that specifically link the sensory input and motor output. Keeping in mind that clinical symptomatology in RLS and cerebrospinal fluid dopamine concentrations in healthy individuals show changes throughout the day, we hypothesized that excitability of the related pathways increases during the night in RLS, and in the present study, we aimed to analyze our hypothesis by the assessment of blink reflex (BR) recovery. Methods Eleven patients with primary RLS and eight age- and gender-matched healthy subjects were included in the study. All participants underwent detailed interviews and neurological examinations. BR responses were recorded after single and paired supraorbital stimulation during the early afternoon and late at night. For double stimulation, interstimulus intervals (ISI) of 100, 300, and 500 ms were used. Daytime and nighttime investigations were separately compared between the patient and control groups (between-group analyses). In-group analyses were conducted between daytime and nighttime investigations of the patient and control groups. Results BR responses to single stimuli were normal in all participants at all sessions. R2 recovery was the highest in the patient group during nighttime investigations. In-group analysis showed a reduction of R2 recovery during the night in healthy subjects. R2 recoveries at ISIs of 300 and 500 ms at nighttime were higher in RLS patients but did not reach statistical significance. Conclusion The BR circuit is less excitable during the night in healthy individuals, whereas the reduction of excitability is lost in RLS. Despite the limited number of included subjects, we suggest that the normal circadian modulation of the BR circuit is lost in RLS. PMID:28373805

  8. Hyperalgesia and functional sensory loss in restless legs syndrome.

    PubMed

    Stiasny-Kolster, Karin; Pfau, Doreen B; Oertel, Wolfgang H; Treede, Rolf-Detlef; Magerl, Walter

    2013-08-01

    Pain and other sensory signs in patients with restless legs syndrome (RLS) are still poorly understood, as most investigations focus on motor system dysfunctions. This study aimed to investigate somatosensory changes in patients with primary RLS and the restoration of somatosensory function by guideline-based treatment. Forty previously untreated RLS patients were investigated unilaterally over hand and foot using quantitative sensory testing (QST) and were compared with 40 age- and gender-matched healthy subjects. The predominant finding in RLS patients was 3- to 4-fold increase of sensitivity to pinprick stimuli in both extremities (hand: P<.05; foot: P<.001), a sensory pathway involved in withdrawal reflexes. Pinprick hyperalgesia was not paralleled by dynamic mechanical allodynia. Additional significant sensory changes were tactile hypoesthesia in both extremities (hand: P<.05; foot P<.01) and dysesthesia to non-noxious cold stimuli (paradoxical heat sensation), which was present in the foot in an unusually high proportion (14 of 40 patients; P<.01). In 8 patients, follow-up QST 2 to 20 months after treatment with l-DOPA (L-3,4-dihydroxyphenylalanine) revealed a significant reduction of pinprick hyperalgesia (-60%, P<.001), improved tactile detection (+50%, P<.05), and disappearance of paradoxical heat sensation in half of the patients. QST suggested a type of spinal or supraspinal central sensitization differing from neuropathic pain or human experimental models of central sensitization by the absence of dynamic mechanical allodynia. Reversal of pinprick hyperalgesia by l-DOPA may be explained by impaired descending inhibitory dopaminergic control on spinal nociceptive neurons. Restoration of tactile sensitivity and paradoxical heat sensations suggest that they were functional disturbances resulting from central disinhibition.

  9. The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells.

    PubMed

    Lacorazza, H Daniel; Yamada, Takeshi; Liu, Yan; Miyata, Yasuhiko; Sivina, Mariela; Nunes, Juliana; Nimer, Stephen D

    2006-03-01

    The transcriptional circuitry that regulates the quiescence of hematopoietic stem cells is largely unknown. We report that the transcription factor known as MEF (or ELF4), which is targeted by the t(X;21)(q26;q22) in acute myelogenous leukemia, regulates the proliferation of primitive hematopoietic progenitor cells at steady state, controlling their quiescence. Mef null HSCs display increased residence in G0 with reduced 5-bromodeoxyuridine incorporation in vivo and impaired cytokine-driven proliferation in vitro. Due to their increased HSC quiescence, Mef null mice are relatively resistant to the myelosuppressive effects of chemotherapy and radiation. Thus, MEF plays an important role in the decision of stem/primitive progenitor cells to divide or remain quiescent by regulating their entry to the cell cycle.

  10. Return to quiescence of murine neural stem cells by degradation of a pro-activation protein

    PubMed Central

    Urbán, Noelia; van den Berg, Debbie L.C.; Forget, Antoine; Andersen, Jimena; Demmers, Jeroen A.; Hunt, Charles; Ayrault, Olivier; Guillemot, François

    2017-01-01

    Quiescence is essential for long-term maintenance of adult stem cells. Niche signals regulate the transit of stem cells from dormant to activated states. Here we show that the E3-ubiquitin ligase Huwe1 (HECT, UBA and WWE domain containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence. Huwe1 destabilises pro-activation protein Ascl1 (achaete-scute family bHLH transcription factor 1) in proliferating hippocampal stem cells, which prevents accumulation of cyclin Ds and promotes the return to a resting state. When stem cells fail to return to quiescence, the proliferative stem cell pool becomes depleted. Thus, long-term maintenance of hippocampal neurogenesis depends on the return of stem cells to a transient quiescent state through the rapid degradation of a key activation factor. PMID:27418510

  11. An array of nuclear microtubules reorganizes the budding yeast nucleus during quiescence

    PubMed Central

    Laporte, Damien; Courtout, Fabien; Salin, Bénédicte; Ceschin, Johanna

    2013-01-01

    The microtubule cytoskeleton is a highly dynamic network. In dividing cells, its complex architecture not only influences cell shape and movement but is also crucial for chromosome segregation. Curiously, nothing is known about the behavior of this cellular machinery in quiescent cells. Here we show that, upon quiescence entry, the Saccharomyces cerevisiae microtubule cytoskeleton is drastically remodeled. Indeed, while cytoplasmic microtubules vanish, the spindle pole body (SPB) assembles a long and stable monopolar array of nuclear microtubules that spans the entire nucleus. Consequently, the nucleolus is displaced. Kinetochores remain attached to microtubule tips but lose SPB clustering and distribute along the microtubule array, leading to a large reorganization of the nucleus. When cells exit quiescence, the nuclear microtubule array slowly depolymerizes and, by pulling attached centromeres back to the SPB, allows the recovery of a typical Rabl-like configuration. Finally, mutants that do not assemble a nuclear array of microtubules are impaired for both quiescence survival and exit. PMID:24247429

  12. Pten is necessary for the quiescence and maintenance of adult muscle stem cells

    PubMed Central

    Yue, Feng; Bi, Pengpeng; Wang, Chao; Shan, Tizhong; Nie, Yaohui; Ratliff, Timothy L.; Gavin, Timothy P.; Kuang, Shihuan

    2017-01-01

    Satellite cells (SCs) are myogenic stem cells required for regeneration of adult skeletal muscles. A proper balance among quiescence, activation and differentiation is essential for long-term maintenance of SCs and their regenerative function. Here we show a function of Pten (phosphatase and tensin homologue) in quiescent SCs. Deletion of Pten in quiescent SCs leads to their spontaneous activation and premature differentiation without proliferation, resulting in depletion of SC pool and regenerative failure. However, prior to depletion, Pten-null activated SCs can transiently proliferate upon injury and regenerate injured muscles, but continually decline during regeneration, suggesting an inability to return to quiescence. Mechanistically, Pten deletion increases Akt phosphorylation, which induces cytoplasmic translocation of FoxO1 and suppression of Notch signalling. Accordingly, constitutive activation of Notch1 prevents SC depletion despite Pten deletion. Our findings delineate a critical function of Pten in maintaining SC quiescence and reveal an interaction between Pten and Notch signalling. PMID:28094257

  13. Restless mind, restless body.

    PubMed

    Seli, Paul; Carriere, Jonathan S A; Thomson, David R; Cheyne, James Allan; Martens, Kaylena A Ehgoetz; Smilek, Daniel

    2014-05-01

    In the present work, we investigate the hypothesis that failures of task-related executive control that occur during episodes of mind wandering are associated with an increase in extraneous movements (fidgeting). In 2 studies, we assessed mind wandering using thought probes while participants performed the metronome response task (MRT), which required them to synchronize button presses with tones. Participants performed this task while sitting on a Wii Balance Board providing us with an index of fidgeting. Results of Study 1 demonstrate that relative to on-task periods, mind wandering is indeed accompanied by increases in fidgeting, as well as increased response variability in the MRT. In Study 2, we observed that only deep mind wandering was associated with increases in fidgeting, whereas task-related response variability increased even during mild mind wandering. We interpret these findings in the context of current theories of mind wandering and suggest that (a) mind wandering is associated with costs not only to primary-task performance but also to secondary-task goals (e.g., controlling extraneous movements) and (b) these costs may depend on the degree to which task-related executive control processes are disengaged during mind wandering (i.e., depth of mind wandering).

  14. Restless Mind, Restless Body

    ERIC Educational Resources Information Center

    Seli, Paul; Carriere, Jonathan S. A.; Thomson, David R.; Cheyne, James Allan; Martens, Kaylena A. Ehgoetz; Smilek, Daniel

    2014-01-01

    In the present work, we investigate the hypothesis that failures of task-related executive control that occur during episodes of mind wandering are associated with an increase in extraneous movements (fidgeting). In 2 studies, we assessed mind wandering using thought probes while participants performed the metronome response task (MRT), which…

  15. Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism

    PubMed Central

    Daubian-Nosé, Paulo; Frank, Miriam K.; Esteves, Andrea Maculano

    2014-01-01

    Restless legs syndrome (RLS) is characterized by unpleasant sensations mainly in the legs. 43% of RLS-associated conditions have also been associated with systemic iron deficiency. The objective of this study was to review in the literature the relationship between iron metabolism and RLS. With an initial search using the keywords combination “Iron Metabolism OR Iron Deficiency AND Restless Legs Syndrome,” 145 articles were screened, and 20 articles were selected. Few studies were found for this review in the period of 2001–2014, however, the correlation between RLS and iron was evident. PMID:26483934

  16. Curious Variables Experiment (CURVE) CCD photometry of QW Serpentis in superoutburst and quiescence

    NASA Astrophysics Data System (ADS)

    Olech, A.; Kȩdzierski, P.; Złoczewski, K.; Mularczyk, K.; Wiśniewski, M.

    2003-12-01

    We report extensive photometry of the dwarf nova QW Ser throughout its February 2003 superoutburst untill quiescence. During the superoutburst the star displayed clear superhumps with a mean period of P_sh = 0.07703(4) days. In the quiescence we observed a double humped wave characterized by a period of P=0.07457(2) days. As both periods obey the Stolz-Schoembs relation with a period excess equal to 3.30+/-0.06%, the latter period is interpreted as the orbital period of the binary system

  17. Theoretical determination of the strength characteristics of multilayer materials intended for nuclear and thermonuclear engineering

    NASA Astrophysics Data System (ADS)

    Vitkovskii, I. V.; Leshukov, A. Yu.; Romashin, S. N.; Shorkin, V. S.

    2015-12-01

    A method is developed to estimate the integrity of multilayer structures. This method is based on the version of the theory of adhesion and cohesion interactions of structure elements that only takes into account their thermomechanical properties. The structures to be studied are the material of the multilayer wall of the liquid-metal thermonuclear reactor blanket and a heat-resistant magnet wire with a bimetallic conductor, which is the base of the windings of the magnetohydrodynamic machines and electric motors intended for operation at high temperatures under ionizing radiation in, e.g., the machines and facilities in nuclear and thermonuclear reactors.

  18. Theoretical z -pinch scaling relations for thermonuclear-fusion experiments.

    PubMed

    Stygar, W A; Cuneo, M E; Vesey, R A; Ives, H C; Mazarakis, M G; Chandler, G A; Fehl, D L; Leeper, R J; Matzen, M K; McDaniel, D H; McGurn, J S; McKenney, J L; Muron, D J; Olson, C L; Porter, J L; Ramirez, J J; Seamen, J F; Speas, C S; Spielman, R B; Struve, K W; Torres, J A; Waisman, E M; Wagoner, T C; Gilliland, T L

    2005-08-01

    implosion time tau(i). For an accelerator coupled to a double-pinch-driven hohlraum that drives the implosion of an ICF fuel capsule, we find that the accelerator power and energy required to achieve high-yield fusion scale as tau(i)0.36 and tau(i)1.36, respectively. Thus the accelerator requirements decrease as the implosion time is decreased. However, the x-ray-power and thermonuclear-yield efficiencies of such a coupled system increase with tau(i). We also find that increasing the anode-cathode gap of the pinch from 2 to 4 mm increases the requisite values of P(a) and E(a) by as much as a factor of 2.

  19. Transdermal rotigotine for the perioperative management of restless legs syndrome

    PubMed Central

    2012-01-01

    Background Immobilisation, blood loss, sleep deficiency, and (concomitant) medications during perioperative periods might lead to acute exacerbation of symptoms in patients with the restless legs syndrome (RLS). Continuous transdermal delivery of the dopamine agonist rotigotine provides stable plasma levels over 24 h and may provide RLS patients with a feasible treatment option for perioperative situations. To assess the feasibility of use of rotigotine transdermal patch for the perioperative management of moderate to severe RLS, long-term data of an open-label extension of a rotigotine dose-finding study were retrospectively reviewed. Methods The data of all 295 patients who had entered the 5-year study were screened independently by two reviewers for the occurrence of surgical interventions during the study period. The following data were included in this post-hoc analysis: patient age, sex, surgical intervention and outcome, duration of hospital stay, rotigotine maintenance dose at the time of surgery, rotigotine dose adjustment, and continuation/discontinuation of rotigotine treatment. All parameters were analysed descriptively. No pre-specified efficacy assessments (e.g. IRLS scores) were available for the perioperative period. Results During the study period, 61 surgical interventions were reported for 52 patients (median age, 63 years; 67% female); the majority of patients (85%) had one surgical intervention. The mean rotigotine maintenance dose at time of surgery was 3.1 ± 1.1 mg/24 h. For most interventions (95%), rotigotine dosing regimens were maintained during the perioperative period. Administration was temporarily suspended in one patient and permanently discontinued in another two. The majority (96%) of the patients undergoing surgery remained in the study following the perioperative period and 30 of these patients (61%) completed the 5-year study. Conclusions Although the data were obtained from a study which was not designed to assess

  20. Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis.

    PubMed

    Pereira, Jose Carlos; Pradella-Hallinan, Marcia; Lins Pessoa, Hugo de

    2010-05-01

    Data collected from medical literature indicate that dopaminergic agonists alleviate Restless Legs Syndrome symptoms while dopaminergic agonists antagonists aggravate them. Dopaminergic agonists is a physiological regulator of thyroid-stimulating hormone. Dopaminergic agonists infusion diminishes the levels of thyroid hormones, which have the ability to provoke restlessness, hyperkinetic states, tremors, and insomnia. Conditions associated with higher levels of thyroid hormones, such as pregnancy or hyperthyroidism, have a higher prevalence of Restless Legs Syndrome symptoms. Low iron levels can cause secondary Restless Legs Syndrome or aggravate symptoms of primary disease as well as diminish enzymatic activities that are involved in dopaminergic agonists production and the degradation of thyroid hormones. Moreover, as a result of low iron levels, dopaminergic agonists diminishes and thyroid hormones increase. Iron therapy improves Restless Legs Syndrome symptoms in iron deprived patients. Medical hypothesis. To discuss the theory that thyroid hormones, when not counterbalanced by dopaminergic agonists, may precipitate the signs and symptoms underpinning Restless Legs Syndrome. The main cause of Restless Legs Syndrome might be an imbalance between the dopaminergic agonists system and thyroid hormones.

  1. Migratory restlessness in captive individuals predicts actual departure in the wild

    PubMed Central

    Eikenaar, Cas; Klinner, Thomas; Szostek, K. Lesley; Bairlein, Franz

    2014-01-01

    In captivity, migratory birds show increased activity during the time that they would normally migrate. The phenology and intensity of such ‘migratory restlessness’ has been shown to mirror species- and population-specific migration patterns observed in the wild and has consequently been used as a proxy for the motivation to migrate. Many studies doing so, however, were aiming to explain among-individual variation in migratory behaviour or traits, and not species- or population-specific traits. These studies thus assumed that, also at the level of the individual, migratory restlessness is an accurate proxy for the motivation to migrate. We tested this assumption for the first time and found that it holds; individuals showing very little migratory restlessness remained at stopover for longer than one night, whereas most individuals showing more restlessness departed sooner. This finding validates the use of migratory restlessness as a proxy for the motivation to migrate, thereby justifying the conclusions made in a large body of research on avian migration. PMID:24718095

  2. Diagnosis and treatment of restless legs syndrome in progressive supranuclear palsy.

    PubMed

    Moccia, Marcello; Picillo, Marina; Erro, Roberto; Allocca, Roberto; Barone, Paolo; Vitale, Carmine

    2015-03-15

    Restless legs syndrome (RLS) has only been recently investigated in a small cohort of progressive supranuclear palsy (PSP) patients and it has been reported to have variable prevalence (among 3.7-58%). However little is known about its management. Here, we report a case of severe RLS occurring during the course of PSP. Diagnostic issues and therapeutic approaches are discussed.

  3. The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence

    SciTech Connect

    Van Dyke, Natalya; Chanchorn, Ekkawit; Van Dyke, Michael W.

    2013-01-11

    Highlights: Black-Right-Pointing-Pointer Stm1p confers increased resistance to the macrolide starvation-mimic rapamycin. Black-Right-Pointing-Pointer Stm1p maintains 80S ribosome integrity during stationary phase-induced quiescence. Black-Right-Pointing-Pointer Stm1p facilitates polysome formation following quiescence exit. Black-Right-Pointing-Pointer Stm1p facilitates protein synthesis following quiescence exit. Black-Right-Pointing-Pointer Stm1p is a ribosome preservation factor under conditions of nutrient deprivation. -- Abstract: Once cells exhaust nutrients from their environment, they enter an alternative resting state known as quiescence, whereby proliferation ceases and essential nutrients are obtained through internal stores and through the catabolism of existing macromolecules and organelles. One example of this is ribophagy, the degradation of ribosomes through the process of autophagy. However, some ribosomes need to be preserved for an anticipated recovery from nutrient deprivation. We found that the ribosome-associated protein Stm1p greatly increases the quantity of 80S ribosomes present in quiescent yeast cells and that these ribosomes facilitate increased protein synthesis rates once nutrients are restored. These findings suggest that Stm1p can act as a ribosome preservation factor under conditions of nutrient deprivation and restoration.

  4. A new role for an old friend: NFAT and stem cell quiescence.

    PubMed

    Oro, Anthony E

    2008-02-07

    NFAT proteins are calcium-regulated transcription factors that play a critical role during the timing and activation of many vertebrate tissues. A recent paper in Cell (Horsley et al., 2008) demonstrates a role of the calcineurin-NFAT-CDK4 pathway in maintaining hair follicle stem cell quiescence.

  5. Pericytes in the myovascular niche promote post-natal myofiber growth and satellite cell quiescence.

    PubMed

    Kostallari, Enis; Baba-Amer, Yasmine; Alonso-Martin, Sonia; Ngoh, Pamela; Relaix, Frederic; Lafuste, Peggy; Gherardi, Romain K

    2015-04-01

    The satellite cells, which serve as adult muscle stem cells, are both located beneath myofiber basement membranes and closely associated with capillary endothelial cells. We observed that 90% of capillaries were associated with pericytes in adult mouse and human muscle. During post-natal growth, newly formed vessels with their neuroglial 2 proteoglycan (NG2)-positive pericytes became progressively associated with the post-natal muscle stem cells, as myofibers increased in size and satellite cells entered into quiescence. In vitro, human muscle-derived pericytes promoted myogenic cell differentiation through insulin-like growth factor 1 (IGF1) and myogenic cell quiescence through angiopoietin 1 (ANGPT1). Diphtheria toxin-induced ablation of muscle pericytes in growing mice led both to myofiber hypotrophy and to impaired establishment of stem cells quiescence. Similar effects were observed following conditional in vivo deletion of pericyte Igf1 and Angpt1 genes, respectively. Our data therefore demonstrate that, by promoting post-natal myogenesis and stem cell quiescence, pericytes play a key role in the microvascular niche of satellite cells.

  6. Pancreatic small cells: Analysis of quiescence, long-term maintenance and insulin expression in vitro

    SciTech Connect

    Petropavlovskaia, M. . E-mail: maria.petropavlovskaia@mail.mcgill.ca; Bodnar, C.A.; Behie, L.A.; Rosenberg, L.

    2007-03-10

    We have previously identified a novel population of small cells in human and canine pancreas characterized by immature morphology, quiescence, and a glucose-responsive insulin secretion. Based on their immature phenotype and predominant presence in small islets, we have hypothesized that small cells serve as islet progenitors. This hypothesis remains untested, however, due to persistent quiescence and scarcity of small cells in vitro. We have recently developed a culture medium that allowed for modest small cell proliferation. In this study we characterized the expression of genes potentially involved in small cell growth regulation by Q-RT-PCR. Our results suggest that quiescence of small cells correlates with up-regulation of Cdk inhibitors p27{sup Kip1}, p16{sup INK4a} and p21{sup CIP1}, PTEN, Hep27 and Foxo1a and with down-regulation of c-Myc and the receptors for EGF, FGF2 and HGF. The exit from quiescence correlates with activation of EGFR expression and down-regulation of p27{sup Kip1} and p16{sup INK4a}. We also report here that small cells can be maintained in long-term non-adherent cultures preserving insulin and glucagon production for up to 208 days. Therefore, expansion of small cells in vitro may have a significant potential for the treatment of diabetes. This study is an important step in understanding the mechanisms involved in small cell growth regulation, which is required to fully evaluate their functional potential.

  7. Probing thermonuclear flame spreading on neutron stars using burst rise oscillations

    NASA Astrophysics Data System (ADS)

    Chakraborty, Manoneeta; Bhattacharyya, Sudip

    2016-07-01

    Intense X-ray bursts (type-I bursts), originated from runaway thermonuclear processes, are observed from the surfaces of many accreting neutron star Low Mass X-ray Binary (LMXB) systems and they provide an important tool to constrain the neutron star equation of state. Periodic intensity variations during these bursts, termed burst oscillations, are observed in about 10% of thermonuclear bursts. Oscillations during the rising phases of thermonuclear bursts are hypothesized to originate from an expanding hot-spot on the surface of the neutron star. We studied the evolution of oscillations during the rising phase of a large sample of thermonuclear bursts from 10 bursting neutron stars in order to probe the process of burning front propagation during an X-ray burst. Our results show observational evidences of expanding hot-spot with spin modulated flame speeds, possibly due to the effects of the Coriolis force present as a result of the high stellar spin (270-620 Hz). This implies that the flame propagation is latitude-dependent and we address the factors affecting the detection and non-detection of burst rise oscillations in the light of this Coriolis force modulated flame spreading scenario.

  8. The onset of seasonal quiescence in the female Bennett's wallaby (Macropus rufogriseus rufogriseus).

    PubMed

    Curlewis, J D; White, A S; Loudon, A S

    1987-05-01

    The breeding season of the non-lactating Bennett's wallaby terminates when animals enter the state of seasonal quiescence. To examine this transition, pouch young were removed from females at intervals which were 3, 4 or 8 weeks (6, 11 and 8 animals respectively) after the winter solstice. Within 48 days, 3, 1 and 1 females gave birth respectively, indicating that these animals were not in seasonal quiescence when pouch young were removed. Those animals which did not give birth were either in seasonal quiescence or had undergone a non-pregnant cycle. To differentiate between the 2 possibilities, techniques which would ensure the detection of pregnant and non-pregnant cycles were assessed in 8 females during the breeding season. As has been previously reported for the wallaby, changes in peripheral progesterone concentrations and the vaginal smear occurred during pregnant and non-pregnant reproductive cycles. In addition, mating was detected by marking the male with a mixture of coloured crayon and paraffin wax. It was concluded that reproductive cycles in female wallabies could be monitored by collecting blood samples 2 times each week for progesterone determination and daily examination of females for mating marks. These techniques were then used to study the onset of seasonal quiescence in 9 females. All animals continued to show reproductive cycles after the winter solstice and it was not until 10 weeks after the winter solstice that all animals were in seasonal quiescence. This represents an increase in the duration of the breeding season over that previously reported for this species.

  9. Transgenic expression of BRCA1 disturbs hematopoietic stem and progenitor cells quiescence and function

    SciTech Connect

    Bai, Lin; Shi, Guiying; Zhang, Xu; Dong, Wei; Zhang, Lianfeng

    2013-10-15

    The balance between quiescence and proliferation of HSCs is an important regulator of hematopoiesis. Loss of quiescence frequently results in HSCs exhaustion, which underscores the importance of tight regulation of proliferation in these cells. Studies have indicated that cyclin-dependent kinases are involved in the regulation of quiescence in HSCs. BRCA1 plays an important role in the repair of DNA double-stranded breaks, cell cycle, apoptosis and transcription. BRCA1 is expressed in the bone marrow. However, the function of BRCA1 in HSCs is unknown. In our study, we generated BRCA1 transgenic mice to investigate the effects of BRCA1 on the mechanisms of quiescence and differentiation in HSCs. The results demonstrate that over-expression of BRCA1 in the bone marrow impairs the development of B lymphocytes. Furthermore, BRCA1 induced an increase in the number of LSKs, LT-HSCs, ST-HSCs and MPPs. A competitive transplantation assay found that BRCA1 transgenic mice failed to reconstitute hematopoiesis. Moreover, BRCA1 regulates the expression of p21{sup waf1}/cip1 and p57{sup kip2}, which results in a loss of quiescence in LSKs. Together, over-expression of BRCA1 in bone marrow disrupted the quiescent of LSKs, induced excessive accumulation of LSKs, and disrupted differentiation of the HSCs, which acts through the down-regulated of p21{sup waf1}/cip1 and p57{sup kip2}. - Highlights: • Over-expression of BRCA1 results in impaired B lymphocyte development. • BRCA1 transgenic mice disrupted the quiescent of LSKs, induced excessive accumulation of LSKs. • BRCA1 impairs the function of HSCs through the down-regulated of p21{sup waf1/cip1} and p57{sup kip2}.

  10. Actigraphic assessment of periodic leg movements in patients with restless legs syndrome.

    PubMed

    Cippà, Maria A T; Baumann, Christian R; Siccoli, Massimiliano M; Bassetti, Claudio L; Poryazova, Rositsa; Werth, Esther

    2013-10-01

    The diagnosis of restless legs syndrome (RLS) relies upon diagnostic criteria which are based on history only, and dopaminergic treatment is not normally the first choice of treatment for all patients. It would be worthwhile to identify patients non-responsive to dopaminergic treatment beforehand, because they may suffer from a restless legs-like syndrome and may require alternative treatment. We included retrospectively 24 adult patients fulfilling the four essential criteria for restless legs and 12 age-matched healthy controls. They were investigated by ambulatory actigraphy from both legs over three nights, and patients started treatment with dopamine agonists after this diagnostic work-up. We examined 12 responders to dopaminergic treatment and 12 non-responders and studied the association between response to dopaminergic treatment and the periodic limb movement index (PLMI) as assessed with actigraphy. Demographic characteristics, excessive daytime sleepiness and fatigue at baseline were similar in all three groups. Baseline RLS severity was similar between responders and non-responders [International Restless Legs Severity Scale (IRLS): 25 ± 9 and 24 ± 8]. Group comparisons of PLMI before treatment initiation showed significant differences between the three groups. Post-hoc pairwise comparisons revealed that healthy controls had significantly lower PLMI (4.9 ± 4.5) than responders (29.3 ± 22.7) and non-responders (13.3 ± 11.2). Similarly, the PLMI in responders was lower than in non-responders. PLMI day-to-day variability did not differ between responders and non-responders and there was no correlation between treatment effect, as assessed by the decrease of the IRLS and baseline PLMI. Our retrospective study indicates that actigraphy to assess periodic limb movements may contribute to a better diagnosis of dopamine-responsive restless legs syndrome.

  11. [Human life and energy production. Prospects opened up by controlled thermonuclear fusion].

    PubMed

    Escande, D

    1997-03-18

    The massive and presently increasing energy production is going to confront mankind with a very important problem in the forthcoming decades, in particular due to the vanishing of resources and to the greenhouse effect. The share of fossil fuels in the energy production will have to decrease, and other energy sources will be needed. Among them controlled thermonuclear fusion has may assets due to its non-radioactive fuel with plentiful supply, its non radioactive and non polluting ashes, its safety, its weak environmental impact, and its irrelevance to nuclear proliferation in a normal setting. During the last three decades, physicists have made a series of steps toward the peaceful use of the dominant source of energy in the Universe. They have learned how to confine by magnetic fields plasmas at temperatures of 200 millions degrees centigrade, and they have developed several specific technologies. This way, they produced 11 million watts of nuclear power by fusing two isotopes of hydrogen. These investigations are conducted in a responsible spirit, that of ecoproduction, where possible negative consequences are anticipated, are made as low as reasonably achievable, and their management is studied. Yet several fundamental issues still have to be solved before on economically efficient industrial thermonuclear power plant be operated. A huge international collaboration involving Japan, the USA, the Russian Federation, and the European Union joined with Switzerland and Canada, is presently designing the first experimental thermonuclear reactor, the International Thermonuclear Experimental Reactor (ITER). It would cost 9 billion dollars, a cost similar to other large scientific projects. This is an important step toward an electricity producing thermonuclear reactor that would be both safe and respectful of human health and of environment.

  12. Intrinsically restless: Unifying science, writing, and the human condition

    NASA Astrophysics Data System (ADS)

    Sissom, Matthew

    The field of physics has always fascinated me, but I never possessed the mathematical skills necessary to extend that interest past the point of curiosity. This thesis was set up to explore how I and other writers, specifically Walt Whitman, use(d) the skills we do have to ask and attempt to answer the same cosmic questions normally reserved for scientists overseeing particle collider experiments. In Tao of Physics, Fritjof Capra attempted to blend the principles of Eastern philosophy with the movements associated with modern physics. In doing so, he offers up a few insights into the human desire to "divide the world into separate objects and events" (117), which I believe, when it comes to fiction, greatly influences the audience's interpretive framework. Capra suggests, "To believe that our abstract concepts of separate `things' and `vents' are realities of nature is an illusion" (117). Humans use this division to cope with our everyday environment, yet it is not a fundamental feature of reality but, rather, an abstraction devised by our discriminating and categorizing intellect. It is a coping mechanism, as Capra refers to it, that pins writers in a corner, encouraging them to forms and styles set by their predecessors to better satisfy the "discriminating and categorizing intellect" of their audience. Writers often struggle to achieve a balance between accurately presenting the human condition that, like Capra's description of subatomic particles as "intrinsically restless" (117), changes based on myriad variables and properly structuring their writing to fit a predetermined model. Whitman, a fan of popular science, drew from the scientific world, using his understanding of the interpretive framework, to better craft his poems' metaphors. In "Song of Myself," Whitman suggests that the celebration of one's own existence cannot be separated from the celebration of the universe, "For every atom belonging to me as good belongs to you" (1-3). Whitman's writing

  13. Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.

    PubMed

    You, Young-jai; Kim, Jeongho; Raizen, David M; Avery, Leon

    2008-03-01

    Despite the prevalence of obesity and its related diseases, the signaling pathways for appetite control and satiety are not clearly understood. Here we report C. elegans quiescence behavior, a cessation of food intake and movement that is possibly a result of satiety. C. elegans quiescence shares several characteristics of satiety in mammals. It is induced by high-quality food, it requires nutritional signals from the intestine, and it depends on prior feeding history: fasting enhances quiescence after refeeding. During refeeding after fasting, quiescence is evoked, causing gradual inhibition of food intake and movement, mimicking the behavioral sequence of satiety in mammals. Based on these similarities, we propose that quiescence results from satiety. This hypothesized satiety-induced quiescence is regulated by peptide signals such as insulin and TGF-beta. The EGL-4 cGMP-dependent protein kinase functions downstream of insulin and TGF-beta in sensory neurons including ASI to control quiescence in response to food intake.

  14. Quantitative thermal sensory testing and sympathetic skin response in primary Restless legs syndrome - A prospective study on 57 Indian patients.

    PubMed

    Shukla, Garima; Goyal, Vinay; Srivastava, Achal; Behari, Madhuri

    2012-10-01

    Patients with restless leg syndrome present with sensory symptoms similar to peripheral neuropathy. While there is evidence of abnormalities of dopaminergic pathways, the peripheral nervous system has been studied infrequently. We studied conventional nerve conduction studies, quantitative thermal sensory testing and sympathetic skin response in 57 patients with primary restless leg syndrome. Almost two third patients demonstrated abnormalities in the detailed testing of the peripheral nervous system. Sbtle abnormalities of the peripheral nervous system may be more common than previously believed.

  15. Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence

    PubMed Central

    Nakagawa, Masahiro Marshall; Thummar, Keyur; Mandelbaum, Jonathan; Pasqualucci, Laura

    2015-01-01

    A balance between quiescence and proliferation is critical for proper maintenance of the hematopoietic stem cell (HSC) pool. Although a lot is known about hematopoiesis, molecular mechanisms that control HSC quiescence remain largely unknown. The ubiquitin-editing enzyme A20 functions as a central regulator of inflammation and adaptive immunity. Here, we show that a deficiency of A20 in the hematopoietic system causes anemia, lymphopenia, and postnatal lethality. Lack of A20 in HSCs results in diminished pool size, impaired radioprotection, defective repopulation, and loss of quiescence. A20-deficient HSCs display increased IFN-γ signaling, caused by augmented NF-κB activation. Strikingly, deletion of both IFN-γ and A20 in hematopoietic cells results in partial rescue of the HSC phenotype. We anticipate that our experiments will facilitate the understanding of mechanisms through which A20-mediated inflammatory signals control HSC quiescence and functions. PMID:25624445

  16. A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit

    PubMed Central

    Laporte, Damien; Courtout, Fabien; Pinson, Benoît; Dompierre, Jim; Salin, Bénédicte; Brocard, Lysiane

    2015-01-01

    Cells perpetually face the decision to proliferate or to stay quiescent. Here we show that upon quiescence establishment, Schizosaccharomyces pombe cells drastically rearrange both their actin and microtubule (MT) cytoskeletons and lose their polarity. Indeed, while polarity markers are lost from cell extremities, actin patches and cables are reorganized into actin bodies, which are stable actin filament–containing structures. Astonishingly, MTs are also stabilized and rearranged into a novel antiparallel bundle associated with the spindle pole body, named Q-MT bundle. We have identified proteins involved in this process and propose a molecular model for Q-MT bundle formation. Finally and importantly, we reveal that Q-MT bundle elongation is involved in polarity reestablishment upon quiescence exit and thereby the efficient return to the proliferative state. Our work demonstrates that quiescent S. pombe cells assemble specific cytoskeleton structures that improve the swiftness of the transition back to proliferation. PMID:26124291

  17. Quiescence Correlates Strongly with Directly Measured Black Hole Mass in Central Galaxies

    NASA Astrophysics Data System (ADS)

    Terrazas, Bryan A.; Bell, Eric F.; Henriques, Bruno M. B.; White, Simon D. M.; Cattaneo, Andrea; Woo, Joanna

    2016-10-01

    Roughly half of all stars reside in galaxies without significant ongoing star formation. However, galaxy formation models indicate that it is energetically challenging to suppress the cooling of gas and the formation of stars in galaxies that lie at the centers of their dark matter halos. In this Letter, we show that the dependence of quiescence on black hole and stellar mass is a powerful discriminant between differing models for the mechanisms that suppress star formation. Using observations of 91 star-forming and quiescent central galaxies with directly measured black hole masses, we find that quiescent galaxies host more massive black holes than star-forming galaxies with similar stellar masses. This observational result is in qualitative agreement with models that assume that effective, more-or-less continuous active galactic nucleus feedback suppresses star formation, strongly suggesting the importance of the black hole in producing quiescence in central galaxies.

  18. The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells.

    PubMed

    Ding, Rouven; Weynans, Kevin; Bossing, Torsten; Barros, Claudia S; Berger, Christian

    2016-01-29

    Stem cells control their mitotic activity to decide whether to proliferate or to stay in quiescence. Drosophila neural stem cells (NSCs) are quiescent at early larval stages, when they are reactivated in response to metabolic changes. Here we report that cell-contact inhibition of growth through the canonical Hippo signalling pathway maintains NSC quiescence. Loss of the core kinases hippo or warts leads to premature nuclear localization of the transcriptional co-activator Yorkie and initiation of growth and proliferation in NSCs. Yorkie is necessary and sufficient for NSC reactivation, growth and proliferation. The Hippo pathway activity is modulated via inter-cellular transmembrane proteins Crumbs and Echinoid that are both expressed in a nutrient-dependent way in niche glial cells and NSCs. Loss of crumbs or echinoid in the niche only is sufficient to reactivate NSCs. Finally, we provide evidence that the Hippo pathway activity discriminates quiescent from non-quiescent NSCs in the Drosophila nervous system.

  19. The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells

    PubMed Central

    Ding, Rouven; Weynans, Kevin; Bossing, Torsten; Barros, Claudia S.; Berger, Christian

    2016-01-01

    Stem cells control their mitotic activity to decide whether to proliferate or to stay in quiescence. Drosophila neural stem cells (NSCs) are quiescent at early larval stages, when they are reactivated in response to metabolic changes. Here we report that cell-contact inhibition of growth through the canonical Hippo signalling pathway maintains NSC quiescence. Loss of the core kinases hippo or warts leads to premature nuclear localization of the transcriptional co-activator Yorkie and initiation of growth and proliferation in NSCs. Yorkie is necessary and sufficient for NSC reactivation, growth and proliferation. The Hippo pathway activity is modulated via inter-cellular transmembrane proteins Crumbs and Echinoid that are both expressed in a nutrient-dependent way in niche glial cells and NSCs. Loss of crumbs or echinoid in the niche only is sufficient to reactivate NSCs. Finally, we provide evidence that the Hippo pathway activity discriminates quiescent from non-quiescent NSCs in the Drosophila nervous system. PMID:26821647

  20. Precursory seismic quiescence along the Sumatra-Andaman subduction zone: past and present

    NASA Astrophysics Data System (ADS)

    Sukrungsri, Santawat; Pailoplee, Santi

    2016-07-01

    In this study, the seismic quiescence prior to hazardous earthquakes was analyzed along the Sumatra-Andaman subduction zone (SASZ). The seismicity data were screened statistically with mainshock earthquakes of M w ≥ 4.4 reported during 1980-2015 being defined as the completeness database. In order to examine the possibility of using the seismic quiescence stage as a marker of subsequent earthquakes, the seismicity data reported prior to the eight major earthquakes along the SASZ were analyzed for changes in their seismicity rate using the statistical Z test. Iterative tests revealed that Z factors of N = 50 events and T = 2 years were optimal for detecting sudden rate changes such as quiescence and to map these spatially. The observed quiescence periods conformed to the subsequent major earthquake occurrences both spatially and temporally. Using suitable conditions obtained from successive retrospective tests, the seismicity rate changes were then mapped from the most up-to-date seismicity data available. This revealed three areas along the SASZ that might generate a major earthquake in the future: (i) Nicobar Islands (Z = 6.7), (ii) the western offshore side of Sumatra Island (Z = 7.1), and (iii) western Myanmar (Z = 6.7). The performance of a stochastic test using a number of synthetic randomized catalogues indicated these levels of anomalous Z value showed the above anomaly is unlikely due to chance or random fluctuations of the earthquake. Thus, these three areas have a high possibility of generating a strong-to-major earthquake in the future.

  1. Oscillations During Thermonuclear X-ray Bursts: A New Probe of Neutron Stars

    NASA Technical Reports Server (NTRS)

    Strohmayer, Tod E.; White, Nicholas E. (Technical Monitor)

    2002-01-01

    Observations of thermonuclear (also called Type 1) X-ray bursts from neutron stars in low mass X-ray binaries (LMXB) with the Rossi X-ray Timing Explorer (RXTE) have revealed large amplitude, high coherence X-ray brightness oscillations with frequencies in the 300 - 600 Hz range. Substantial spectral and timing evidence point to rotational modulation of the X-ray burst flux as the cause of these oscillations, and it is likely that they reveal the spin frequencies of neutron stars in LMXB from which they are detected. Here we review the status of our knowledge of these oscillations and describe how they can be used to constrain the masses and radii of neutron stars as well as the physics of thermonuclear burning on accreting neutron stars.

  2. Compression and combustion of non-cryogenic targets with a solid thermonuclear fuel for inertial fusion

    NASA Astrophysics Data System (ADS)

    Gus'kov, S. Yu.; Zmitrenko, N. V.; Sherman, V. E.

    2013-04-01

    Variants of a target with a solid thermonuclear fuel in the form of deuterium-tritium hydrides of light metals for an inertial fusion have been proposed. The laser-pulse-induced compression of non-cryogenic targets, as well as ignition and combustion of such targets, has been examined. The numerical calculations show that, despite a decrease in the caloric content of the fuel and an increase in the energy losses on intrinsic radiation in the target containing deuterium-tritium hydrides of light metals as compared to the target containing deuterium-tritium ice, the non-cryogenic target can ensure the fusion gain sufficient for its use in the energy cycle of a thermonuclear power plant based on the inertial plasma confinement method.

  3. Compression and combustion of non-cryogenic targets with a solid thermonuclear fuel for inertial fusion

    SciTech Connect

    Gus'kov, S. Yu.; Zmitrenko, N. V.; Sherman, V. E.

    2013-04-15

    Variants of a target with a solid thermonuclear fuel in the form of deuterium-tritium hydrides of light metals for an inertial fusion have been proposed. The laser-pulse-induced compression of non-cryogenic targets, as well as ignition and combustion of such targets, has been examined. The numerical calculations show that, despite a decrease in the caloric content of the fuel and an increase in the energy losses on intrinsic radiation in the target containing deuterium-tritium hydrides of light metals as compared to the target containing deuterium-tritium ice, the non-cryogenic target can ensure the fusion gain sufficient for its use in the energy cycle of a thermonuclear power plant based on the inertial plasma confinement method.

  4. Transcriptional quiescence of paternal mtDNA in cyprinid fish embryos

    PubMed Central

    Wen, Ming; Peng, Liangyue; Hu, Xinjiang; Zhao, Yuling; Liu, Shaojun; Hong, Yunhan

    2016-01-01

    Mitochondrial homoplasmy signifies the existence of identical copies of mitochondrial DNA (mtDNA) and is essential for normal development, as heteroplasmy causes abnormal development and diseases in human. Homoplasmy in many organisms is ensured by maternal mtDNA inheritance through either absence of paternal mtDNA delivery or early elimination of paternal mtDNA. However, whether paternal mtDNA is transcribed has remained unknown. Here we report that paternal mtDNA shows late elimination and transcriptional quiescence in cyprinid fishes. Paternal mtDNA was present in zygotes but absent in larvae and adult organs of goldfish and blunt-snout bream, demonstrating paternal mtDNA delivery and elimination for maternal mtDNA inheritance. Surprisingly, paternal mtDNA remained detectable up to the heartbeat stage, suggesting its late elimination leading to embryonic heteroplasmy up to advanced embryogenesis. Most importantly, we never detected the cytb RNA of paternal mtDNA at all stages when paternal mtDNA was easily detectable, which reveals that paternal mtDNA is transcriptionally quiescent and thus excludes its effect on the development of heteroplasmic embryos. Therefore, paternal mtDNA in cyprinids shows late elimination and transcriptional quiescence. Clearly, transcriptional quiescence of paternal mtDNA represents a new mechanism for maternal mtDNA inheritance and provides implications for treating mitochondrion-associated diseases by mitochondrial transfer or replacement. PMID:27334806

  5. Transcriptional Control of Cell-Cycle Quiescence During C. elegans Development

    PubMed Central

    Clayton, Joseph E.; van den Heuvel, Sander J.L.; Saito, R. Mako

    2008-01-01

    During the development of the C. elegans reproductive system, cells that give rise to the vulva, the vulval precursor cells (VPCs), remain quiescent for two larval stages before resuming cell division in the third larval stage. We have identified several transcriptional regulators that contribute to this temporary cell-cycle arrest. Mutation of lin-1 or lin-31, two downstream targets of the Receptor Tyrosine kinase (RTK)/Ras/MAP kinase cascade that controls VPC cell fate, disrupts the temporary VPC quiescence. We found that the LIN-1/Ets and LIN-31/FoxB transcription factors promote expression of CKI-1, a member of the p27 family of cyclin-dependent kinase inhibitors (CKIs). LIN-1 and LIN-31 promote cki-1/Kip-1 transcription prior to their inhibition through RTK/Ras/MAPK activation. Another mutation identified in the screen defined the mdt-13 TRAP240 Mediator subunit. Further analysis of the multisubunit Mediator complex revealed that a specific subset of its components act in VPC quiescence. These components substantially overlap with the CDK-8 module implicated in transcriptional repression. Taken together, strict control of cell-cycle quiescence during VPC development involves transcriptional induction of CKI-1 and transcriptional regulation through the Mediator complex. These transcriptional regulators represent potential molecular connections between development and the basic cell-cycle machinery. PMID:18082681

  6. The Dwarf Novae UZ Serpentis and SS Aurigae During Quiescence: Exposed White Dwarfs?

    NASA Astrophysics Data System (ADS)

    Lake, J.; Sion, E. M.

    2000-12-01

    UZ Serpentis and SS Aurigae are both U Geminorum-type dwarf novae with similar orbital periods, outburst amplitudes, and outburst recurrence times. Since dwarf novae above the period gap have higher accretion rates, their accretion disks may remain optically thick even during quiescence. Hence the detection of the white dwarf is more difficult. UZ Ser and SS Aur offer the possiblity of extending the range of systems for which the underlying white dwarf accreter has been analyzed with model atmospheres. We have applied the Massa-Fitzpatrick (2000) flux calibration correction to the archival IUE NEWSIPS SWP spectra of these two systems, obtained during dwarf nova quiescence. We have carried out high gravity model atmosphere using the codes TLUSTY195, SYNSPEC42, ROTIN and accretion disk synthetic spectra from the grid of Wade and Hubeny (1998). We have determined the physical properties of the white dwarf accreters, including temperature, gravity chemical abundances estimates, and the accretion rate during quiescence. We discuss our results in the context of the overall picture of accretion physics in dwarf novae and the effects of accretion on the white dwarf. This research was supported in part by NSF grant AST 99-01955, NASA ADP grant NAG5-8388 and by summer research funding from the NASA- Delaware Space Grant Colleges Consortium.

  7. A Genetic Screen for Saccharomyces cerevisiae Mutants That Fail to Enter Quiescence

    PubMed Central

    Li, Lihong; Miles, Shawna; Breeden, Linda L.

    2015-01-01

    Budding yeast begin the transition to quiescence by prolonging G1 and accumulating limited nutrients. They undergo asymmetric cell divisions, slow cellular expansion, acquire significant stress tolerance and construct elaborate cell walls. These morphologic changes give rise to quiescent (Q) cells, which can be distinguished from three other cell types in a stationary phase culture by flow cytometry. We have used flow cytometry to screen for genes that are required to obtain the quiescent cell fraction. We find that cell wall integrity is critical and these genes may help define quiescence-specific features of the cell wall. Genes required to evade the host innate immune response are common. These may be new targets for antifungal drugs. Acquired thermotolerance is also a common property, and we show that the stress-response transcription factors Msn2 and Msn4 promote quiescence. Many other pathways also contribute, including a subset of genes involved in autophagy, ubiquitin-mediated proteolysis, DNA replication, bud site selection, and cytokinesis. PMID:26068574

  8. A Genetic Screen for Saccharomyces cerevisiae Mutants That Fail to Enter Quiescence.

    PubMed

    Li, Lihong; Miles, Shawna; Breeden, Linda L

    2015-06-10

    Budding yeast begin the transition to quiescence by prolonging G1 and accumulating limited nutrients. They undergo asymmetric cell divisions, slow cellular expansion, acquire significant stress tolerance and construct elaborate cell walls. These morphologic changes give rise to quiescent (Q) cells, which can be distinguished from three other cell types in a stationary phase culture by flow cytometry. We have used flow cytometry to screen for genes that are required to obtain the quiescent cell fraction. We find that cell wall integrity is critical and these genes may help define quiescence-specific features of the cell wall. Genes required to evade the host innate immune response are common. These may be new targets for antifungal drugs. Acquired thermotolerance is also a common property, and we show that the stress-response transcription factors Msn2 and Msn4 promote quiescence. Many other pathways also contribute, including a subset of genes involved in autophagy, ubiquitin-mediated proteolysis, DNA replication, bud site selection, and cytokinesis.

  9. Do Quiescence and Wasp Venom-Induced Lethargy Share Common Neuronal Mechanisms in Cockroaches?

    PubMed Central

    2017-01-01

    The escape behavior of a cockroach may not occur when it is either in a quiescent state or after being stung by the jewel wasp (Ampulex compressa). In the present paper, we show that quiescence is an innate lethargic state during which the cockroach is less responsive to external stimuli. The neuronal mechanism of such a state is poorly understood. In contrast to quiescence, the venom-induced lethargic state is not an innate state in cockroaches. The Jewel Wasp disables the escape behavior of cockroaches by injecting its venom directly in the head ganglia, inside a neuropile called the central complex a ‘higher center’ known to regulate motor behaviors. In this paper we show that the coxal slow motoneuron ongoing activity, known to be involved in posture, is reduced in quiescent animals, as compared to awake animals, and it is further reduced in stung animals. Moreover, the regular tonic firing of the slow motoneuron present in both awake and quiescent cockroaches is lost in stung cockroaches. Injection of procaine to prevent neuronal activity into the central complex to mimic the wasp venom injection produces a similar effect on the activity of the slow motoneuron. In conclusion, we speculate that the neuronal modulation during the quiescence and venom-induced lethargic states may occur in the central complex and that both states could share a common neuronal mechanism. PMID:28045911

  10. Short communication: measures of weight distribution and frequency of steps as indicators of restless behavior.

    PubMed

    Chapinal, N; de Passillé, A M; Rushen, J; Tucker, C B

    2011-02-01

    Restless behavior, as measured by the steps taken or weight shifting between legs, may be a useful tool to assess the comfort of dairy cattle. These behaviors increase when cows stand on uncomfortable surfaces or are lame. The objective of this study was to compare 2 measures of restless behavior, stepping behavior and changes in weight distribution, on 2 standing surfaces: concrete and rubber. Twelve cows stood on a weighing platform with 1 scale/hoof for 1h. The platform was covered with either concrete or rubber, presented in a crossover design. Restlessness, as measured by both the frequency of steps and weight shifting (measured as the standard deviation of weight applied over time to the legs), increased over 1h of forced standing on either concrete or rubber. A positive relationship was found between the frequency of steps and the standard deviation of weight over 1h for both treatments and pairs of legs (r ≥ 0.66). No differences existed in the standard deviation of weight applied to the front (27.6 ± 1.6 kg) or rear legs (33.5 ± 1.4 kg) or the frequency of steps (10.2 ± 1.6 and 20.8 ± 3.2 steps/10 min for the front and rear pair, respectively) between rubber and concrete. Measures of restlessness are promising tools for assessing specific types of discomfort, such as those associated with lameness, but additional tools are needed to assess comfort of non-concrete standing surfaces.

  11. The historical record for Sirius - Evidence for a white-dwarf thermonuclear runaway?

    NASA Technical Reports Server (NTRS)

    Bruhweiler, Frederick C.; Kondo, Yoji; Sion, Edward M.

    1986-01-01

    Evidence was recently presented that in medieval times Sirius was a bright red star, rather than the present bluish-white star. Here, the results of attempts to detect possible planetary nebula ejecta toward Sirius using data obtained by the IUE are presented. Based on these results and in the light of recent advances in understanding white-dwarf evolution, it is proposed that Sirius B underwent a recent thermonuclear runaway event triggered by a diffusion-induced CN reaction.

  12. A Deep Search for Prompt Radio Emission from Thermonuclear Supernovae with the Very Large Array

    NASA Astrophysics Data System (ADS)

    Chomiuk, Laura; Soderberg, Alicia M.; Chevalier, Roger A.; Bruzewski, Seth; Foley, Ryan J.; Parrent, Jerod; Strader, Jay; Badenes, Carles; Fransson, Claes; Kamble, Atish; Margutti, Raffaella; Rupen, Michael P.; Simon, Joshua D.

    2016-04-01

    Searches for circumstellar material around Type Ia supernovae (SNe Ia) are some of the most powerful tests of the nature of SN Ia progenitors, and radio observations provide a particularly sensitive probe of this material. Here, we report radio observations for SNe Ia and their lower-luminosity thermonuclear cousins. We present the largest, most sensitive, and spectroscopically diverse study of prompt ({{Δ }}t≲ 1 years) radio observations of 85 thermonuclear SNe, including 25 obtained by our team with the unprecedented depth of the Karl G. Jansky Very Large Array. With these observations, SN 2012cg joins SN 2011fe and SN 2014J as an SN Ia with remarkably deep radio limits and excellent temporal coverage (six epochs, spanning 5-216 days after explosion, implying \\dot{M}/{v}w≲ 5× 10-9 M⊙) yr-1/(100 km s-1), assuming ɛB = 0.1 and ɛe = 0.1). All observations yield non-detections, placing strong constraints on the presence of circumstellar material. We present analytical models for the temporal and spectral evolution of prompt radio emission from thermonuclear SNe as expected from interaction with either wind-stratified or uniform density media. These models allow us to constrain the progenitor mass loss rates, with limits in the range of \\dot{M}≲ 10-9-10-4 M⊙ yr-1, assuming a wind velocity of vw = 100 km s-1. We compare our radio constraints with measurements of Galactic symbiotic binaries to conclude that ≲10% of thermonuclear SNe have red giant companions.

  13. Frontiers in propulsion research: Laser, matter-antimatter, excited helium, energy exchange thermonuclear fusion

    NASA Technical Reports Server (NTRS)

    Papailiou, D. D. (Editor)

    1975-01-01

    Concepts are described that presently appear to have the potential for propulsion applications in the post-1990 era of space technology. The studies are still in progress, and only the current status of investigation is presented. The topics for possible propulsion application are lasers, nuclear fusion, matter-antimatter annihilation, electronically excited helium, energy exchange through the interaction of various fields, laser propagation, and thermonuclear fusion technology.

  14. Insomnia and limb pain in hemodialysis patients: what is the share of restless leg syndrome?

    PubMed

    Malaki, Majid; Mortazavi, Fakhr Sadat; Moazemi, Sussan; Shoaran, Maryam

    2012-01-01

    Insomnia and limb pain are common problems in dialysis patients. In addition, restless leg syndrome (RLS) as a specific cause of insomnia and limb pain has been reported in many studies. The purpose of this study was to estimate incidence of insomnia and RLS as a cause of insomnia in these patients. Twenty-six patients undergoing hemodialysis were investigated for insomnia, limb pain and RLS as per the defined criteria. They were evaluated for dialysis quality, dialysis duration, hemoglobin, serum phosphorous, ionized calcium, iron and ferritin levels. These variables between patients with insomnia and those with normal sleep were evaluated by independent "t" test. Without considering the etiology or pathogenesis of insomnia, we evaluated the occurrence of insomnia and limb pain in these patients, and specifically, restless leg syndrome. Insomnia and limb pain were common in dialytic patients. 46% of patients had insomnia. 91% of sleepless group had limb pain as a persistent, annoying complaint. Limb pain was not seen in groups with a normal sleep pattern. Restless leg syndrome was found in 8% of total cases (2 out of 26) and 17% among the insomnia group (2 out of 12). In spite of high incidence of insomnia among patients undergoing regular hemodialysis, role of RLS is trivial. There is a strong relationship between hemoglobin levels and duration of renal replacement therapy to insomnia occurrence.

  15. Rocket propulsion by thermonuclear micro-bombs ignited with intense relativistic electron beams.

    NASA Technical Reports Server (NTRS)

    Winterberg, F.

    1971-01-01

    Discussion of a method for the ignition of a thermonuclear microbomb by means of an intense relativistic electron beam with regard to its potential application to rocket propulsion. With such a system, exhaust velocities up to 1000 km/sec, corresponding to a specific impulse of 100,000 sec, seem to be within the realm of possibility. The rocket is propelled by a chain of thermonuclear microbombs exploded in a concave magnetic mirror produced by superconducting field coils. The magnetic pressure of the field reflects the fireball generated by the explosion. For the large capacitor bank required to generate the intense relativistic electron beam, a desirable lightweight design may be possible through use of ferroelectric materials. Because of the high cost of the T-D and He 3-D thermonuclear material, the system has to be optimized by minimizing the T-D and He 3-D consumption by a proper TD and He 3-D fuel to hydrogen propellant mass ratio, leading to a larger total system mass than would be absolutely necessary.

  16. The optical counterparts of accreting millisecond X-ray pulsars during quiescence

    NASA Astrophysics Data System (ADS)

    D'Avanzo, P.; Campana, S.; Casares, J.; Covino, S.; Israel, G. L.; Stella, L.

    2009-12-01

    Context: Eight accreting millisecond X-ray pulsars (AMXPs) are known to date. Although these systems are well studied at high energies, very little information is available for their optical/NIR counterparts. Up to now, only two of them, SAX J1808.4-3658 and IGR J00291+5934, have a secure multi-band detection of their optical counterparts in quiescence. Aims: All these systems are transient low-mass X-ray binaries. Optical and NIR observations carried out during quiescence give a unique opportunity to constrain the nature of the donor star and to investigate the origin of the observed quiescent luminosity at long wavelengths. In addition, optical observations can be fundamental as they ultimately allow us to estimate the compact object mass through mass function measurements. Methods: Using data obtained with the ESO-Very Large Telescope, we performed a deep optical and NIR photometric study of the fields of XTE J1814-338 and of the ultracompact systems XTE J0929-314 and XTE J1807-294 during quiescence in order to look for the presence of a variable counterpart. If suitable candidates were found, we also carried out optical spectroscopy. Results: We present here the first multi-band (VR) detection of the optical counterpart of XTE J1814-338 in quiescence together with its optical spectrum. The optical light curve shows variability in both bands consistent with a sinusoidal modulation at the known 4.3 h orbital period and presents a puzzling decrease of the V-band flux around superior conjunction that may be interpreted as a partial eclipse. The marginal detection of the very faint counterpart of XTE J0929-314 and deep upper limits for the optical/NIR counterpart of XTE J1807-294 are also reported. We also briefly discuss the results reported in the literature for the optical/NIR counterpart of XTE J1751-305. Conclusions: Our findings are consistent with AMXPs being systems containing an old, weakly magnetized neutron star, reactivated as a millisecond radio pulsar

  17. The effects of two methods of reflexology and stretching exercises on the severity of restless leg syndrome among hemodialysis patients

    PubMed Central

    Shahgholian, Nahid; Jazi, Shahrzad Khojandi; Karimian, Jahangir; Valiani, Mahboubeh

    2016-01-01

    Background: Restless leg syndrome prevalence is high among the patients undergoing hemodialysis. Due to several side effects of medicational treatments, the patients prefer non-medicational methods. Therefore, the present study aimed to investigate the effects of two methods of reflexology and stretching exercises on the severity of restless leg syndrome among patients undergoing hemodialysis. Materials and Methods: This study is a randomized clinical trial that was done on 90 qualified patients undergoing hemodialysis in selected hospitals of Isfahan, who were diagnosed with restless leg syndrome through standard restless leg syndrome questionnaire. They were randomly assigned by random number table to three groups: Reflexology, stretching exercises, and control groups through random allocation. Foot reflexology and stretching exercises were conducted three times a week for 30–40 min within straight 4 weeks. Data analysis was performed by SPSS version 18 using descriptive and inferential statistical analyses [one-way analysis of variance (ANOVA), paired t-test, and least significant difference (LSD) post hoc test]. Results: There was a significant difference in the mean scores of restless leg syndrome severity between reflexology and stretching exercises groups, compared to control (P < 0.001), but there was no significant difference between the two study groups (P < 0.001). Changes in the mean score of restless leg syndrome severity were significantly higher in reflexology and stretching exercises groups compared to the control group (P < 0.001), but it showed no significant difference between reflexology massage and stretching exercises groups. Conclusions: Our obtained results showed that reflexology and stretching exercises can reduce the severity of restless leg syndrome. These two methods of treatment are recommended to the patients. PMID:27186197

  18. Thermonuclear Processes as a Principal Source of the Earth's Internal Energy

    NASA Astrophysics Data System (ADS)

    Terez, E. I.; Terez, I. E.

    2011-12-01

    A cosmological model of the formation of the Solar System is presented. It is shown that the main source of the Earth's energy is delivered from the thermonuclear processes in the inner Earth's core consisting of metallic hydrides. Several theoretical studies showed that under low temperature (T<104 K) and sufficiently high density of plasma, the characteristics of nuclear synthesis could be explained only with some adjustments to a thermonuclear synthesis theory. By building a diagram of the mass luminosity for the giant planets and the Earth, Wang Hong-Zhang (1990) illustrated that this diagram was similar to the one corresponding to stars. This could have only one explanation-the energy is due to the thermonuclear reactions and the energy rate is increasing exponentially with temperature and pressure. In the local areas where thermonuclear reactions occur in the Earth core, one should expect a sharp increase in temperature which causes of the dissolution of hydrides, e.g. release of hydrogen from the hydride-ionic form to the proton gas in large quantities (Larin, 2005). The pressure in this zone would sharply rise, and this would cause expulsion of the streams of the hydrogen plasma outside of the Earth's core. As a result of the Earth rotation and existence of the Coriolis' acceleration, the hydrogen plumes (more exactly, the proton gas) characterized by a high electrical conductivity twirl in spirals in the outer core of the Earth. These spirals form solenoid and, as a result, create the dipole magnetic field of the Earth. The suggest hypothesis of the thermonuclear nature of the Earth's energy flux is a main reason for the endogenic geodynamic and tectonic processes in the Earth's history. This hypothesis is supported by known experimental facts, and it opens new ways to study not only our planet but other planets of the Solar System. One should note that according to accepted concepts, the dipole magnetic field could exist in planets with a sufficient

  19. THE X-RAY SPECTRAL EVOLUTION OF GALACTIC BLACK HOLE X-RAY BINARIES TOWARD QUIESCENCE

    SciTech Connect

    Plotkin, Richard M.; Gallo, Elena; Jonker, Peter G.

    2013-08-10

    Most transient black hole X-ray binaries (BHXBs) spend the bulk of their time in a quiescent state, where they accrete matter from their companion star at highly sub-Eddington luminosities (we define quiescence here as a normalized Eddington ratio l{sub x} = L{sub 0.5-10{sub keV}}/L{sub Edd} < 10{sup -5}). Here, we present Chandra X-ray imaging spectroscopy for three BHXB systems (H 1743-322, MAXI J1659-152, and XTE J1752-223) as they fade into quiescence following an outburst. Multiple X-ray observations were taken within one month of each other, allowing us to track each individual system's X-ray spectral evolution during its decay. We compare these three systems to other BHXB systems. We confirm that quiescent BHXBs have softer X-ray spectra than low-hard-state BHXBs, and that quiescent BHXB spectral properties show no dependence on the binary system's orbital parameters. However, the observed anti-correlation between X-ray photon index ({Gamma}) and l{sub x} in the low-hard state does not continue once a BHXB enters quiescence. Instead, {Gamma} plateaus to an average ({Gamma}) = 2.08 {+-} 0.07 by the time l{sub x} reaches {approx}10{sup -5}. l{sub x} {approx} 10{sup -5} is thus an observationally motivated upper limit for the beginning of the quiescent spectral state. Our results are discussed in the context of different accretion flow models and across the black hole mass scale.

  20. Viscous evolution of accretion discs in the quiescence of dwarf novae

    NASA Technical Reports Server (NTRS)

    Mineshige, Shin; Wood, Janet H.

    1989-01-01

    Viscous evolution of accretion disks in the quiescence of dwarf novae is investigated semi-analytically. There are two key factors: the inward flow of the initial mass in the disk and the diffusion of the material added into the disk. The results are compared with the brightness temperature distributions obtained by the eclipse mapping of Z Cha and OY Car. The functional form of the viscosity parameter a, its values, the types of outbursts, and the application to soft X-ray transients are discussed.

  1. Rearrangements of DNA-protein interactions in animal cells coupled with cellular growth-quiescence transitions.

    PubMed Central

    Lichtenstein, A V; Sjakste, N I; Zaboykin, M M; Shapot, V S

    1982-01-01

    Overall DNA-protein interactions in animal cells undergo drastic changes coupled with cellular transitions from quiescence to growth and reversely as revealed by nucleoprotein-Celite chromatography. DNA of chromatin was found to exist in one of the two sharply distinct alternative forms, namely, either tightly or weakly bound to protein moiety. These forms are specific for cycling and quiescent cells, respectively. The tight DNA-protein interactions characterize all cycling cells independent of the cell cycle phase. Transition of DNA of cycling cells from one form to another was observed as a result of treatment of isolated nuclei with DNase I. PMID:7063419

  2. A theoretical integration of Cambrian explosion and post-Permian quiescence.

    PubMed

    Takahara, Y; Ono, N

    1997-01-01

    Trophic dynamics is internally causative. Each trophic level is causative in initiating changes in trophic flow either as a supplier towards the upper level or as a consumer towards the lower. Resource presentation followed by its subsequent exploitation makes suppliers causative, while resource exploitation followed by its subsequent presentation makes consumers causative. Trophic dynamics of supplier domination gradually alternates with that of consumer domination while being punctuated by occasional mass extinctions due to depletion of the resources towards the lowest trophic level. The Cambrian explosion could be associated with trophic dynamics of supplier domination, whereas the post-Permian quiescence with that of consumer influencing supplier domination.

  3. Water stress can induce quiescence in newly-germinated onion (Allium cepa L.) seedlings.

    PubMed

    Whalley, W R; Lipiec, J; Finch-Savage, W E; Cope, R E; Clark, L J; Rowse, H R

    2001-05-01

    The effect of water stress on the early seedling growth of onions was studied by placing newly-germinated seedlings in vermiculite equilibrated at different water potentials. Roots and shoots elongated more at -0.29 than at -0.64 MPa, but did not elongate at -1.66 MPa. However, roots and shoots of seedlings that had been incubated in vermiculite at -1.66 MPa for up to 35 d resumed elongation when subsequently placed on wet filter boards. This suggests that water stress can induce quiescence in newly-germinated seedlings.

  4. Alternative approaches to the design of targets for a hybrid thermonuclear station

    SciTech Connect

    Basov, N G; Lebo, I G; Rozanov, Vladislav B; Feoktistov, L P; Tishkin, V F

    1998-04-30

    Targets with low degrees of compression, such as those with internal energy deposition, two-stage conical targets for lasers emitting pulses of duration of the order of 100 ns, and multilayer shell targets for short-pulse long-wavelength CO{sub 2} and CO lasers may prove acceptable for hybrid thermonuclear reactors with high values (of the order of 10{sup 3}) of the gain in the blanket. Estimates and one-dimensional calculations of the compression of such targets are reported for the laser radiation energy range 0.2-2 MJ. (interaction of laser radiation with matter. laser plasma)

  5. Fermi-GBM detection of a thermonuclear burst from 4U 1608-52

    NASA Astrophysics Data System (ADS)

    Jenke, P.; Linares, M.; Connaughton, V.; van der Horst, A. J.; Camero-Arranz, A.; Finger, M.; Wilson-Hodge, C.; Kouveliotou, C.

    2012-05-01

    We report the detection with Fermi-GBM (daily CTIME data, 12-25 keV band) of an X-ray burst from a location consistent with the neutron star low-mass X-ray binary and thermonuclear burster 4U 1608-52. The burst peak occurred on May 2, 2012 at 06:47:54 UTC. The Fermi-GBM location of the burst is R.A.(J2000) = 241.3 deg, DEC(J2000) = -51.1 deg (1.8 deg from 4U 1608-52) with a 1 sigma error of 4.7 deg.

  6. Thermonuclear reaction rate of 18Ne(α ,p ) 21Na from Monte Carlo calculations

    NASA Astrophysics Data System (ADS)

    Mohr, P.; Longland, R.; Iliadis, C.

    2014-12-01

    The 18Ne(α ,p ) 21Na reaction impacts the break-out from the hot CNO cycles to the r p process in type-I x-ray bursts. We present a revised thermonuclear reaction rate, which is based on the latest experimental data. The new rate is derived from Monte Carlo calculations, taking into account the uncertainties of all nuclear physics input quantities. In addition, we present the reaction rate uncertainty and probability density versus temperature. Our results are also consistent with estimates obtained using different indirect approaches.

  7. Randomized, double-blind, placebo-controlled study of clonidine in restless legs syndrome.

    PubMed

    Wagner, M L; Walters, A S; Coleman, R G; Hening, W A; Grasing, K; Chokroverty, S

    1996-01-01

    Ten patients with idiopathic restless leg syndrome (RLS) were asked to rate their symptoms at baseline during 2 weeks of placebo and 2 weeks of clonidine treatment by using a four-point scale. On two consecutive nights each treatment period, polysomnography (PSG) and actigraphic studies were performed. Patients subjectively reported improvement in leg sensations (p = 0.02) and motor restlessness (p = 0.001) while receiving clonidine (mean = 0.05 mg/day). On PSG testing, sleep onset occurred faster with clonidine (12 minutes) compared with placebo (30 minutes) and baseline (47 minutes) (p = 0.006). Adverse findings associated with clonidine treatment included decreased percent REM sleep in the clonidine group (4%) compared with placebo (16%) and baseline (16%) (p = 0.001) and increased REM latency in the clonidine group (195 minutes) compared to the placebo (70 minutes) and baseline groups (89 minutes) (p = 0.028). There were no significant changes in total sleep time, stage 1 and 2 sleep, sleep efficiency, awakenings, arousals or periodic limb movements in sleep. There was a nonstatistical trend toward and increase in stage 3 and 4 sleep and a decrease in motor activity as measured by actigraphic recordings. Globally, seven out of 10 patients felt clonidine was more effective than placebo. Four patients chose to continue clonidine after the study. Clonidine may be an effective treatment for RLS patients who don't have large numbers of sleep-disrupting periodic limb movements but have delayed sleep onset due to leg sensations and subsequent motor restlessness.

  8. Lifestyle Factors and Risk of Restless Legs Syndrome: Prospective Cohort Study

    PubMed Central

    Batool-Anwar, Salma; Li, Yanping; De Vito, Katerina; Malhotra, Atul; Winkelman, John; Gao, Xiang

    2016-01-01

    Study Objectives: To examine the association between modifiable lifestyle factors, and the risk of developing restless legs syndrome (RLS). Methods: This is a Prospective Cohort study of population including 12,812 men participating in Health Professionals Follow-up Study and 42,728 women participating in the Nurses' Health study II. The participants were free of RLS at baseline (2002 for the HPFS and 2005 for the NHS II) and free of diabetes and arthritis through follow-up. RLS was assessed via a set of questions recommended by International Restless Legs Syndrome Study group. The Information was collected on height, weight, level of physical activity, dietary intake, and smoking status via questionnaires. Results: During 4–6 years of follow-up, we identified 1,538 incident RLS cases. Participants with normal weight, and who were physically active, non-smoker, and had some alcohol consumption had a lower risk of developing RLS. When we combined the effects of these four factors together, we observed a dose response relationship between the increased number of healthy lifestyle factors and a low risk of RLS: after adjusting for potential confounders the pooled odds ratio was 0.67 (95% CI: 0.47–0.97) for 4 vs.0 healthy factors (p trend < 0.001). In contrast, we did not observe significant associations between caffeine consumption or diet quality as assessed by the Alternate Healthy Eating Index, and altered RLS risk in men and women. Conclusions: Several modifiable lifestyle factors may play an important role in RLS risk. Citation: Batool-Anwar S, Li Y, De Vito K, Malhotra A, Winkelman J, Gao X. Lifestyle factors and risk of restless legs syndrome: prospective cohort study. J Clin Sleep Med 2016;12(2):187–194. PMID:26446243

  9. Long-term open-label study of pramipexole in patients with primary restless legs syndrome.

    PubMed

    Inoue, Yuichi; Kuroda, Kenji; Hirata, Koichi; Uchimura, Naohisa; Kagimura, Tatsuo; Shimizu, Tetsuo

    2010-07-15

    A phase III, open-label, long-term clinical study was performed to evaluate the safety and efficacy of pramipexole in a cohort of 141 Japanese patients with primary restless legs syndrome (RLS). The patients were started on pramipexole 0.25 mg/day and were subsequently maintained on that dose or switched to 0.125, 0.5, or 0.75 mg/day to achieve optimal efficacy and tolerability. The International Restless Legs Syndrome Study Group Rating Scale for restless legs syndrome (IRLS) score improved from 22.3+/-4.7 at baseline to 11.1+/-7.7 at week 8 and 4.9+/-5.9 at week 52. IRLS responders, defined as patients whose IRLS total score decreased by > or =50% from baseline, accounted for 67.4% at week 12 and 86.6% at week 52. Over 90% of patients were Clinical Global Impression-global improvement (CGI-I) and Patient Global Impression (PGI) responders. The Pittsburgh Sleep Quality Index (PSQI) score decreased from 7.9+/-3.1 at baseline to 4.6+/-2.9 at week 52. Similarly, the Japanese version of the Epworth Sleepiness Scale score decreased from 9.3+/-5.2 to 4.9+/-3.8. Baseline IRLS score < or =20 was significantly associated with a complete IRLS response in this long-term study. Adverse events were typical of nonergot dopamine agonists, mild in intensity, and decreased in frequency as the study progressed. RLS augmentation was not observed. Pramipexole 0.25-0.75 mg/day is efficacious, safe, and well tolerated in patients with RLS. Pramipexole showed good efficacy, particularly in patients with an IRLS total score <20.

  10. FROM THE HISTORY OF PHYSICS: The extraordinarily beautiful physical principle of thermonuclear charge design (on the occasion of the 50th anniversary of the test of RDS-37 — the first Soviet two-stage thermonuclear charge)

    NASA Astrophysics Data System (ADS)

    Goncharov, German A.

    2005-11-01

    On 22 November 1955, the Semipalatinsk test site saw the test of the first domestic two-stage thermonuclear RDS-37 charge. The charge operation was based on the principle of radiation implosion. The kernel of the principle consists in the radiation generated in a primary A-bomb explosion and confined by the radiation-opaque casing propagating throughout the interior casing volume and flowing around the secondary thermonuclear unit. The secondary unit experiences a strong compression under the irradiation, with a resulting nuclear and thermonuclear explosion. The RDS-37 explosion was the strongest of all those ever realized at the Semipalatinsk test site. It produced an indelible impression on the participants in the test. This document-based paper describes the genesis of the ideas underlying the RDS-37 design and reflects the critical moments in its development. The advent of RDS-37 was an outstanding accomplishment of the scientists and engineers of our country.

  11. Medical devices for restless legs syndrome – clinical utility of the Relaxis pad

    PubMed Central

    Mitchell, Ulrike H

    2015-01-01

    Restless Legs Syndrome or Willis–Ekbom Disease, a neurosensory disorder, can be treated with pharmaceuticals or conservatively. This review focuses on conservative treatments, more specifically on treatments with medical devices. Two modes of action, enhancement of circulation and counter stimulation, are introduced. Medical devices that use enhancement of circulation as their mechanism of action are whole body vibration, pneumatic compression, and near-infrared light. Medical devices that use counter stimulation include transcutaneous electrical nerve stimulation and the vibration Relaxis pad. The clinical utility of the Relaxis pad and its place in therapy is proposed. PMID:26664128

  12. Plans for living on a restless planet sets NASA's solid Earth agenda

    NASA Technical Reports Server (NTRS)

    Solomon, S. C.; Baker, V. R.; Bloxham, J.; Booth, J.; Donnellan, A.; Elachi, C.; Evans, D.; Rignot, E.; Burbank, D.; Chao, B. F.; Chave, A.; Gillespie, A.; Herring, T.; Jeanloz, R.; LaBrecque, J.; Minster, B.; Pitman, W. C., III; Simons, M.; Turcotte, D. L.; Zoback, M. L.

    2003-01-01

    What are the most important challenges facing solid Earth science today and over the next two decades? And what is the best approach for NASA, in partnership with other agencies, to address these challenges? A new report, living on a restless planet, provides a blueprint for answering these questions. The top priority for a new spacecraft mission in the area of solid earth science over the next 5 years, according to this report, is a satellite dedicated to interferometric synthetic aperture radar(inSAR).

  13. Medical devices for restless legs syndrome - clinical utility of the Relaxis pad.

    PubMed

    Mitchell, Ulrike H

    2015-01-01

    Restless Legs Syndrome or Willis-Ekbom Disease, a neurosensory disorder, can be treated with pharmaceuticals or conservatively. This review focuses on conservative treatments, more specifically on treatments with medical devices. Two modes of action, enhancement of circulation and counter stimulation, are introduced. Medical devices that use enhancement of circulation as their mechanism of action are whole body vibration, pneumatic compression, and near-infrared light. Medical devices that use counter stimulation include transcutaneous electrical nerve stimulation and the vibration Relaxis pad. The clinical utility of the Relaxis pad and its place in therapy is proposed.

  14. Management of Restless Legs Syndrome/Willis-Ekbom Disease in Hospitalized and Perioperative Patients.

    PubMed

    Goldstein, Cathy

    2015-09-01

    Restless legs syndrome (RLS) is a sensorimotor disorder that can cause significant discomfort, impaired quality of life, poor mood, and disturbed sleep. Because the disorder is chronic and associated with multiple comorbidities, RLS can be seen in an inpatient or perioperative setting. Certain characteristics of the hospitalized or surgical context can exacerbate or unmask RLS. Importantly, RLS and the associated discomfort and insomnia can prolong hospital stay and negatively impact outcomes. RLS medications should be continued during the hospital admission when possible. Avoidance of excessive phlebotomy and medications known to trigger RLS is helpful. Patients should increase activity when acceptable.

  15. Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal

    PubMed Central

    Chandrakesan, Parthasarathy; May, Randal; Qu, Dongfeng; Weygant, Nathaniel; Taylor, Vivian E.; Li, James D.; Ali, Naushad; Sureban, Sripathi M.; Qante, Michael; Wang, Timothy C.; Bronze, Michael S.; Houchen, Courtney W.

    2015-01-01

    To date, no discrete genetic signature has been defined for isolated Dclk1+ tuft cells within the small intestine. Furthermore, recent reports on the functional significance of Dclk1+ cells in the small intestine have been inconsistent. These cells have been proposed to be fully differentiated cells, reserve stem cells, and tumor stem cells. In order to elucidate the potential function of Dclk1+ cells, we FACS-sorted Dclk1+ cells from mouse small intestinal epithelium using transgenic mice expressing YFP under the control of the Dclk1 promoter (Dclk1-CreER;Rosa26-YFP). Analysis of sorted YFP+ cells demonstrated marked enrichment (~6000 fold) for Dclk1 mRNA compared with YFP− cells. Dclk1+ population display ~6 fold enrichment for the putative quiescent stem cell marker Bmi1. We observed significantly greater expression of pluripotency genes, pro-survival genes, and quiescence markers in the Dclk1+ population. A significant increase in self-renewal capability (14-fold) was observed in in vitro isolated Dclk1+ cells. The unique genetic report presented in this manuscript suggests that Dclk1+ cells may maintain quiescence, pluripotency, and metabolic activity for survival/longevity. Functionally, these reserve characteristics manifest in vitro, with Dclk1+ cells exhibiting greater ability to self-renew. These findings indicate that quiescent stem-like functionality is a feature of Dclk1-expressing tuft cells. PMID:26362399

  16. Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay

    PubMed Central

    Hausburg, Melissa A; Doles, Jason D; Clement, Sandra L; Cadwallader, Adam B; Hall, Monica N; Blackshear, Perry J; Lykke-Andersen, Jens; Olwin, Bradley B

    2015-01-01

    Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population. To understand the mechanisms involved in maintaining satellite cell quiescence, we identified gene transcripts that were differentially expressed during satellite cell activation following muscle injury. Transcripts encoding RNA binding proteins were among the most significantly changed and included the mRNA decay factor Tristetraprolin. Tristetraprolin promotes the decay of MyoD mRNA, which encodes a transcriptional regulator of myogenic commitment, via binding to the MyoD mRNA 3′ untranslated region. Upon satellite cell activation, p38α/β MAPK phosphorylates MAPKAP2 and inactivates Tristetraprolin, stabilizing MyoD mRNA. Satellite cell specific knockdown of Tristetraprolin precociously activates satellite cells in vivo, enabling MyoD accumulation, differentiation and cell fusion into myofibers. Regulation of mRNAs by Tristetraprolin appears to function as one of several critical post-transcriptional regulatory mechanisms controlling satellite cell homeostasis. DOI: http://dx.doi.org/10.7554/eLife.03390.001 PMID:25815583

  17. Degassing during quiescence as a trigger of magma ascent and volcanic eruptions.

    PubMed

    Girona, Társilo; Costa, Fidel; Schubert, Gerald

    2015-12-15

    Understanding the mechanisms that control the start-up of volcanic unrest is crucial to improve the forecasting of eruptions at active volcanoes. Among the most active volcanoes in the world are the so-called persistently degassing ones (e.g., Etna, Italy; Merapi, Indonesia), which emit massive amounts of gas during quiescence (several kilotonnes per day) and erupt every few months or years. The hyperactivity of these volcanoes results from frequent pressurizations of the shallow magma plumbing system, which in most cases are thought to occur by the ascent of magma from deep to shallow reservoirs. However, the driving force that causes magma ascent from depth remains unknown. Here we demonstrate that magma ascent can be triggered by the passive release of gas during quiescence, which induces the opening of pathways connecting deep and shallow magma reservoirs. This top-down mechanism for volcanic eruptions contrasts with the more common bottom-up mechanisms in which magma ascent is only driven by processes occurring at depth. A cause-effect relationship between passive degassing and magma ascent can explain the fact that repose times are typically much longer than unrest times preceding eruptions, and may account for the so frequent unrest episodes of persistently degassing volcanoes.

  18. The Thermal State of KS 1731-260 after 14.5 years in Quiescence

    NASA Astrophysics Data System (ADS)

    Merritt, Rachael L.; Cackett, Edward M.; Brown, Edward F.; Page, Dany; Cumming, Andrew; Degenaar, Nathalie; Deibel, Alex; Homan, Jeroen; Miller, Jon M.; Wijnands, Rudy

    2016-12-01

    Crustal cooling of accretion-heated neutron stars provides insight into the stellar interior of neutron stars. The neutron star X-ray transient, KS 1731-260, was in outburst for 12.5 years before returning to quiescence in 2001. We have monitored the cooling of this source since then through Chandra and XMM-Newton observations. Here we present a 150 ks Chandra observation of KS 1731-260 taken in 2015 August, about 14.5 years into quiescence and 6 years after the previous observation. We find that the neutron star surface temperature is consistent with the previous observation, suggesting that crustal cooling has likely stopped and the crust has reached thermal equilibrium with the core. Using a theoretical crust thermal evolution code, we fit the observed cooling curves and constrain the core temperature (T c = 9.35 ± 0.25 × 107 K), composition (Q {}{imp}={4.4}-0.5+2.2), and level of extra shallow heating required (Q sh = 1.36 ± 0.18 MeV/nucleon). We find that the presence of a low thermal conductivity layer, as expected from nuclear pasta, is not required to fit the cooling curve well, but cannot be excluded either.

  19. The Dwarf Novae Ty Psc and V436 Cen During Quiescence: Exposed White Dwarfs?

    NASA Astrophysics Data System (ADS)

    Nadalin, I.; Sion, E. M.

    2000-12-01

    The dwarf novae TY Psc and V436 Cen are SU UMa systems with very similar orbital periods, similar recurrence times for normal outbursts ( 23 days) and superoutbursts ( ~ 340 days) and nearly identical outburst amplitudes. We have applied the Massa-Fitzpatrick (2000) flux calibration correction to the archival IUE NEWSIPS SWP spectra of these two systems, obtained during dwarf nova quiescence. We have carried out high gravity model atmosphere using the codes TLUSTY195, SYNSPEC42, ROTIN and accretion disk synthetic spectra from the grid of Wade and Hubeny (1998). We present our results on the physical properties of the underlying white dwarf accreters, including temperature, gravity, chemical abundances estimates, and the accretion rate during quiescence. We discuss our results in the context of the overall picture of accretion physics in dwarf novae and the effects of accretion on the white dwarf. This research was supported in part by NSF grant AST 99-01955, NASA ADP grant NAG5-8388 and by summer research funding from the NASA- Delaware Space Grant Colleges Consortium.

  20. Degassing during quiescence as a trigger of magma ascent and volcanic eruptions

    PubMed Central

    Girona, Társilo; Costa, Fidel; Schubert, Gerald

    2015-01-01

    Understanding the mechanisms that control the start-up of volcanic unrest is crucial to improve the forecasting of eruptions at active volcanoes. Among the most active volcanoes in the world are the so-called persistently degassing ones (e.g., Etna, Italy; Merapi, Indonesia), which emit massive amounts of gas during quiescence (several kilotonnes per day) and erupt every few months or years. The hyperactivity of these volcanoes results from frequent pressurizations of the shallow magma plumbing system, which in most cases are thought to occur by the ascent of magma from deep to shallow reservoirs. However, the driving force that causes magma ascent from depth remains unknown. Here we demonstrate that magma ascent can be triggered by the passive release of gas during quiescence, which induces the opening of pathways connecting deep and shallow magma reservoirs. This top-down mechanism for volcanic eruptions contrasts with the more common bottom-up mechanisms in which magma ascent is only driven by processes occurring at depth. A cause-effect relationship between passive degassing and magma ascent can explain the fact that repose times are typically much longer than unrest times preceding eruptions, and may account for the so frequent unrest episodes of persistently degassing volcanoes. PMID:26666396

  1. Stress tolerance during diapause and quiescence of the brine shrimp, Artemia.

    PubMed

    MacRae, Thomas H

    2016-01-01

    Oviparously developing embryos of the brine shrimp, Artemia, arrest at gastrulation and are released from females as cysts before entering diapause, a state of dormancy and stress tolerance. Diapause is terminated by an external signal, and growth resumes if conditions are permissible. However, if circumstances are unfavorable, cysts enter quiescence, a dormant stage that continues as long as adverse conditions persist. Artemia embryos in diapause and quiescence are remarkably resistant to environmental and physiological stressors, withstanding desiccation, cold, heat, oxidation, ultraviolet radiation, and years of anoxia at ambient temperature when fully hydrated. Cysts have adapted to stress in several ways; they are surrounded by a rigid cell wall impermeable to most chemical compounds and which functions as a shield against ultraviolet radiation. Artemia cysts contain large amounts of trehalose, a non-reducing sugar thought to preserve membranes and proteins during desiccation by replacing water molecules and/or contributing to vitrification. Late embryogenesis abundant proteins similar to those in seeds and other anhydrobiotic organisms are found in cysts, and they safeguard cell organelles and proteins during desiccation. Artemia cysts contain abundant amounts of p26, a small heat shock protein, and artemin, a ferritin homologue, both ATP-independent molecular chaperones important in stress tolerance. The evidence provided in this review supports the conclusion that it is the interplay of these protective elements that make Artemia one of the most stress tolerant of all metazoan organisms.

  2. NR2F1 controls tumor cell dormancy via SOX9 and RARβ driven quiescence programs

    PubMed Central

    Sosa, Maria Soledad; Parikh, Falguni; Maia, Alexandre Gaspar; Estrada, Yeriel; Bosch, Almudena; Bragado, Paloma; Ekpin, Esther; George, Ajish; Zheng, Yang; Lam, Hung-Ming; Morrissey, Colm; Chung, Chi-Yeh; Farias, Eduardo F.; Bernstein, Emily; Aguirre-Ghiso, Julio A.

    2014-01-01

    Metastases can originate from disseminated tumor cells (DTCs), which may be dormant for years before reactivation. Here we find that the orphan nuclear receptor NR2F1 is epigenetically upregulated in experimental HNSCC dormancy models and in DTCs from prostate cancer patients carrying dormant disease for 7–18 years. NR2F1-dependent dormancy is recapitulated by a co-treatment with the DNA demethylating agent 5-Aza-C and retinoic acid across various cancer types. NR2F1-induced quiescence is dependent on SOX9, RARβ and CDK inhibitors. Intriguingly, NR2F1 induces global chromatin repression and the pluripotency gene NANOG, which contributes to dormancy of DTCs in the bone marrow. When NR2F1 is blocked in vivo, growth arrest or survival of dormant DTCs is interrupted in different organs. We conclude that NR2F1 is a critical node in dormancy induction and maintenance by integrating epigenetic programs of quiescence and survival in DTCs. PMID:25636082

  3. Degassing during quiescence as a trigger of magma ascent and volcanic eruptions

    NASA Astrophysics Data System (ADS)

    Girona, Társilo; Costa, Fidel; Schubert, Gerald

    2015-12-01

    Understanding the mechanisms that control the start-up of volcanic unrest is crucial to improve the forecasting of eruptions at active volcanoes. Among the most active volcanoes in the world are the so-called persistently degassing ones (e.g., Etna, Italy; Merapi, Indonesia), which emit massive amounts of gas during quiescence (several kilotonnes per day) and erupt every few months or years. The hyperactivity of these volcanoes results from frequent pressurizations of the shallow magma plumbing system, which in most cases are thought to occur by the ascent of magma from deep to shallow reservoirs. However, the driving force that causes magma ascent from depth remains unknown. Here we demonstrate that magma ascent can be triggered by the passive release of gas during quiescence, which induces the opening of pathways connecting deep and shallow magma reservoirs. This top-down mechanism for volcanic eruptions contrasts with the more common bottom-up mechanisms in which magma ascent is only driven by processes occurring at depth. A cause-effect relationship between passive degassing and magma ascent can explain the fact that repose times are typically much longer than unrest times preceding eruptions, and may account for the so frequent unrest episodes of persistently degassing volcanoes.

  4. The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The regeneration of the hematopoietic system in bone marrow after chemotherapy depends on a balance between the quiescence and proliferation of lineage-specific progenitor cells. Even though the vascular network in bone is damaged by cytoablation, the transcriptional control of quiescence in endothe...

  5. Analysis of Tokamak Fusion Test Reactor (TFTR) Prototype of International Thermonuclear Experimental Reactor (ITER)‡

    NASA Astrophysics Data System (ADS)

    Hester, Tim; Maglich, Bogdan; Scott, Dan; Calsec Collaboration

    2015-11-01

    TFTR produced world record of 10 million watts of controlled fusion power1 (CFP-1994) was summarized in Review1. We present evidence3 that: (1) TFTR input vs. output was 40 to 10 MW i.e. a power loss. (2) Review claims no experimental evidence for thermonuclear CFP production (only a calculation). (3) Ultra-high vacuum (UHV) required for τE = 0.2 s is 10-9 torr. TFTR had no UHV pumps, resulting in 10-3 torr, restricting τE <10-6 s, << thermalization time; 0.1 s., hence DT plasma did not occur. (4) Carbon ions were presented as D-T plasma. (5) Unknown neutron detector on unexplained neutron diamagnetic effect, measured ``fusion neutron power'' without particle energy identification, energy or coincidence. (6) 8 of 9 parameters claimed were inferred not measured. Quadratic test of TFTR data results2 in zero thermonuclear fusion power contribution to 10 MW: SFP = (0 +/- 1)%. ‡ Submitted to Physics of Plasmas†

  6. On the helical instability and efficient stagnation pressure production in thermonuclear magnetized inertial fusion

    NASA Astrophysics Data System (ADS)

    Sefkow, A. B.

    2016-10-01

    Magneto-inertial fusion experiments produce thermonuclear neutrons from plasma compressed to high convergence via z-pinch. Fusion fuel contained within a cylindrical metal liner is premagnetized with an axial field and laser-preheated prior to the liner's implosion by the JxB force. Convergence greater than 40 is inferred from x-ray self-emission spectroscopy and backlit x-ray radiography. The unprecedented stability is enabled by helical modes induced in the magnetized liner, the cause of which will be discussed, because of the suppression of the ubiquitous m=0 modes of the magneto-Rayleigh-Taylor instability found in many z-pinch implosions. The plasma temperature and flux are compressed to several keV and 100 MG at stagnation, enough to magnetically trap alpha particles and provide ``bootstrap'' self-heating when scaled to larger fusion yields with DT fuel. We present quantitative comparison between experimental observables and 3D modeling in support of the interpretation that this approach to laboratory fusion can scale to larger thermonuclear yields. Namely, the implosions efficiently convert liner kinetic energy to stagnated fuel internal energy with the expected pressures of 1 Gbar and burn durations of 2 ns, in agreement with both 2D and 3D modeling. Therefore, the analysis indicates the magnetized hot-spot dynamics are not dominated by implosion instability or residual kinetic energy in our best-performing experiments, wherein laser-induced non-fuel mix into the forming hot spot is low.

  7. Stabilization of burn conditions in a thermonuclear reactor using artificial neural networks

    NASA Astrophysics Data System (ADS)

    Vitela, Javier E.; Martinell, Julio J.

    1998-02-01

    In this work we develop an artificial neural network (ANN) for the feedback stabilization of a thermonuclear reactor at nearly ignited burn conditions. A volume-averaged zero-dimensional nonlinear model is used to represent the time evolution of the electron density, the relative density of alpha particles and the temperature of the plasma, where a particular scaling law for the energy confinement time previously used by other authors, was adopted. The control actions include the concurrent modulation of the D-T refuelling rate, the injection of a neutral He-4 beam and an auxiliary heating power modulation, which are constrained to take values within a maximum and minimum levels. For this purpose a feedforward multilayer artificial neural network with sigmoidal activation function is trained using a back-propagation through-time technique. Numerical examples are used to illustrate the behaviour of the resulting ANN-dynamical system configuration. It is concluded that the resulting ANN can successfully stabilize the nonlinear model of the thermonuclear reactor at nearly ignited conditions for temperature and density departures significantly far from their nominal operating values. The NN-dynamical system configuration is shown to be robust with respect to the thermalization time of the alpha particles for perturbations within the region used to train the NN.

  8. Reevaluation of thermonuclear reaction rate of 50Fe(p, 𝜸)51Co

    NASA Astrophysics Data System (ADS)

    Zhang, Li-Ping; He, Jian-Jun; Chai, Wan-Dong; Hou, Su-Qing; Zhang, Li-Yong

    2016-11-01

    The thermonuclear rate of the 50Fe(p, 𝜸)51Co reaction in the Type I X-ray bursts (XRBs) temperature range has been reevaluated based on a recent precise mass measurement at CSRe Lanzhou, where the proton separation energy Sp = 142±77 keV has been determined firstly for the 51Co nucleus. Comparing to the previous theoretical predictions, the experimental Sp value has much smaller uncertainty. Based on the nuclear shell model and mirror nuclear structure information, we have calculated two sets of thermonuclear rates for the 50Fe(p, 𝜸)51Co reaction by utilizing the experimental Sp value. It shows that the statistical-model calculations are not ideally applicable for this reaction primarily because of the low density of low-lying excited states in 51Co. In this work, we recommend that a set of new reaction rates based on the mirror structure of 51Cr should be incorporated in future astrophysical network calculations. Supported by Natural Science Foundation of Inner Mongolia Autonomous Region of China (2013MS0916) and National Natural Science Foundation of China (11490562, 11405228)

  9. 30S(α , p) Thermonuclear Reaction Rate from Experimental Level Structure of 34Ar

    NASA Astrophysics Data System (ADS)

    Kahl, D.; Chen, A. A.; Kubono, S.; Yamaguchi, H.; Binh, D. N.; Chen, J.; Cherubini, S.; Duy, N. N.; Hashimoto, T.; Hayakawa, S.; Iwasa, N.; Jung, H. S.; Kato, S.; Kwon, Y. K.; Nishimura, S.; Ota, S.; Setoodehnia, K.; Teranishi, T.; Tokieda, H.; Yamada, T.; Yun, C. C.; Zhang, L. Y.

    Type I X-ray bursts are the most frequent thermonuclear explosions in the galaxy. Owing to their recurrence from known astronomical objects, burst morphology is extensively documented, and they are modeled very successfully as neutron-deficient, thermonuclear runaway on the surface of accreting neutron stars. While reaction networks include hundreds of isotopes and thousands of nuclear processes, only a small subset appear to play a pivotal role. One such reaction is the 30S(α , p) reaction, which is believed to be a crucial link in the explosive helium burning which is responsible for the large energy flux. However, very little experimental information is available concerning the cross section itself, nor the 34Ar compound nucleus at the relevant energies. We performed the first study of the entrance channel via 30S alpha resonant elastic scattering using a state-of-the-art, low-energy, 30S radioactive ion beam. The measurement was performed in inverse kinematics using a newly-developed active target. An R-matrix analysis of the excitation function reveals previously unknown resonances, including their quantum properties of spin, parity, width, and energy.

  10. Matching of experimental and statistical-model thermonuclear reaction rates at high temperatures

    NASA Astrophysics Data System (ADS)

    Newton, Joseph; Longland, Richard; Iliadis, Christian

    2009-05-01

    Reliable reaction rates at high stellar temperatures are necessary for the study of advanced stellar burning stages, supernovae and x-ray bursts. We suggest a new procedure for extrapolating experimental thermonuclear reaction rates to these higher temperatures (T > 1 GK) using statistical model (Hauser-Feshbach) results. Current, generally accepted, procedures involve the use of the Gamow peak, which has been shown to be unreliable for narrow resonances at high stellar temperatures [1]. Our new approach defines the effective thermonuclear energy range (ETER) by using the 8^th, 50^th and 92^nd percentiles of the cumulative distribution of fractional resonant reaction contributions. The ETER is then used to define a reliable temperature for matching experimental rates to Hauser-Feshbach rates. The resulting matching temperature is often well above the previous result using the Gamow peak concept. Our new method should provide more accurate extrapolated rates since Hauser-Feshbach rates are more reliable at higher temperatures. These ideas are applied to 21 (p,γ), (p,α) and (α,γ) reactions on a range of A = 20-40 target nuclei and results will be presented. [0pt] [1] J. R. Newton, C. Iliadis, A. E. Champagne, A. Coc, Y. Parpottas and R. Ugalde, Phys. Rev. C 75, 045801 (2007).

  11. Matching of experimental and statistical-model thermonuclear reaction rates at high temperatures

    NASA Astrophysics Data System (ADS)

    Newton, J. R.; Longland, R.; Iliadis, C.

    2008-08-01

    We address the problem of extrapolating experimental thermonuclear reaction rates toward high stellar temperatures (T>1 GK) by using statistical model (Hauser-Feshbach) results. Reliable reaction rates at such temperatures are required for studies of advanced stellar burning stages, supernovae, and x-ray bursts. Generally accepted methods are based on the concept of a Gamow peak. We follow recent ideas that emphasized the fundamental shortcomings of the Gamow peak concept for narrow resonances at high stellar temperatures. Our new method defines the effective thermonuclear energy range (ETER) by using the 8th, 50th, and 92nd percentiles of the cumulative distribution of fractional resonant reaction rate contributions. This definition is unambiguous and has a straightforward probability interpretation. The ETER is used to define a temperature at which Hauser-Feshbach rates can be matched to experimental rates. This matching temperature is usually much higher compared to previous estimates that employed the Gamow peak concept. We suggest that an increased matching temperature provides more reliable extrapolated reaction rates since Hauser-Feshbach results are more trustwhorthy the higher the temperature. Our ideas are applied to 21 (p,γ), (p,α), and (α,γ) reactions on A=20-40 target nuclei. For many of the cases studied here, our extrapolated reaction rates at high temperatures differ significantly from those obtained using the Gamow peak concept.

  12. Two-sided conical laser target for a neutron source of a hybrid nuclear-thermonuclear reactor

    NASA Astrophysics Data System (ADS)

    Lebo, I. G.; Isaev, E. A.; Lebo, A. I.

    2017-03-01

    Numerical simulations suggest that a source of thermonuclear neutrons with a high pulse repetition rate and the number of neutrons of ~1017 per pulse, which is required for the development of nuclear-thermonuclear reactors, can be realised in the irradiation of a two-sided conical target simultaneously by a long and short laser pulses with energies of ~1 MJ and 50 kJ and durations of 100 – 250 ns and 0.1 – 1 ns. We consider the feasibility of verifying separate propositions of the proposed conception with the use of existing laser facilities.

  13. The TDF System for Thermonuclear Plasma Reaction Rates, Mean Energies and Two-Body Final State Particle Spectra

    SciTech Connect

    Warshaw, S I

    2001-07-11

    The rate of thermonuclear reactions in hot plasmas as a function of local plasma temperature determines the way in which thermonuclear ignition and burning proceeds in the plasma. The conventional model approach to calculating these rates is to assume that the reacting nuclei in the plasma are in Maxwellian equilibrium at some well-defined plasma temperature, over which the statistical average of the reaction rate quantity {sigma}v is calculated, where {sigma} is the cross-section for the reaction to proceed at the relative velocity v between the reacting particles. This approach is well-understood and is the basis for much nuclear fusion and astrophysical nuclear reaction rate data. The Thermonuclear Data File (TDF) system developed at the Lawrence Livermore National Laboratory (Warshaw 1991), which is the topic of this report, contains data on the Maxwellian-averaged thermonuclear reaction rates for various light nuclear reactions and the correspondingly Maxwellian-averaged energy spectra of the particles in the final state of those reactions as well. This spectral information closely models the output particle and energy distributions in a burning plasma, and therefore leads to more accurate computational treatments of thermonuclear burn, output particle energy deposition and diagnostics, in various contexts. In this report we review and derive the theoretical basis for calculating Maxwellian-averaged thermonuclear reaction rates, mean particle energies, and output particle spectral energy distributions for these reactions in the TDF system. The treatment of the kinematics is non-relativistic. The current version of the TDF system provides exit particle energy spectrum distributions for two-body final state reactions only. In a future report we will discuss and describe how output particle energy spectra for three- and four-body final states can be developed for the TDF system. We also include in this report a description of the algorithmic implementation of the

  14. [Neurophysiological and neuroimaging studies for restless legs syndrome and periodic leg movement disorder].

    PubMed

    Happe, S; Paulus, W

    2006-06-01

    The restless legs syndrome (RLS) is a clinical diagnosis based on the four essential criteria defined by the International Restless Legs Syndrome Study Group (IRLSSG). An idiopathic form can be separated from a symptomatic form. Neurophysiological studies have investigated the pathophysiology of the idiopathic RLS or have been used to exclude a symptomatic cause, in particular polyneuropathy. So far cortical excitability changes, corticomotor, somatosensory and auditory pathways, spinal cord excitability, B-wave rhythm and cycling alternating pattern, as well as reflex mechanisms have been investigated by electroencephalography, evoked potentials, Bereitschaftspotentials, nerve conduction and thermal threshold measurements, electromyography, transcranial Doppler sonography, measurements of the spinal flexor reflex as well as neuroimaging techniques. The etiology of the RLS cannot be revealed by these methods, neurophysiological studies in RLS are, however, useful for a better understanding of the pathophysiology and for exclusion of a polyneuropathy or other symptomatic causes. In addition to neurophysiological investigations, small fiber neuropathy, which seems to be a more common finding in RLS patients than expected to date, may need biopsy for confirmation. This review will focus on investigations of the different systems involved with diverse neurophysiological methods.

  15. Clinical management of restless legs syndrome in end-stage renal disease patients.

    PubMed

    Sahli, Zeyad T; Jo, Jae; Mousa, Shaker A; Tarazi, Frank I

    2017-02-01

    Restless legs syndrome (RLS) is a common neurological movement disorder, characterized by restless and unpleasant sensations in the deep inside of legs. The symptoms of RLS are less noticeable during daytime, but more prevalent at night. Therefore, the disorder can induce low quality of life, insomnia, and impairment of daytime activity. RLS in end-stage renal disease (ESRD) patients is especially problematic due to premature discontinuation of dialysis and increased mortality. The prevalence of RLS among dialysis patients is much higher compared to the prevalence of the same disorder in patients with normal renal functions. Even though there are recommended treatment guidelines for the general population established by Medical Advisory Board of the RLS foundation, which include the use of dopamine agonists, levodopa, gabapentin, benzodiazepines, and opioids, limited information is available on the effects of these therapies in ESRD patients. Since the existing clinical data were extrapolated from small sample sizes in short-term clinical trials, further clinical studies are still needed to better assess the efficacy, safety, and tolerability of these medications in patients with ESRD.

  16. Using near infrared light to manage symptoms associated with restless legs syndrome.

    PubMed

    Guffey, J Stephen; Motts, Susan; Barymon, Deanna; Wooten, Amber; Clough, Tim; Payne, Emily; Henderson, McCall; Tice, Neal

    2016-01-01

    The purpose of this study was to determine whether the application of near infrared (NIR) light could positively modulate symptoms associated with restless legs syndrome (RLS). Twenty-one subjects with RLS were treated with NIR three times weekly for four weeks. Baseline measures of: (1) international restless legs syndrome rating scale (IRLSRS) score; (2) Semmes Weinstein monofilament (SWM) test; (3) visual analog pain scale (VAS); (4) ankle-brachial index (ABI); and (5) sonographic imaging of the popliteal and posterior tibial arteries were compared to post-treatment values. NIR (850 nm) was delivered transcutaneously at 8 J/cm(2) to four locations on each leg and the plantar surface of each foot. A pre-test-post-test one group design was employed. Baseline and post-treatment measures were compared using either a dependent t-test when data were normal or the Wilcoxon signed rank test in the absence of normality. A significant improvement in IRLSRS scores was observed. Sensation improved from less than protective in 16.6% of sites tested at the baseline to 13.4% post-intervention. There was a significant improvement in ABI scores. VAS and sonographic imaging measures other than ABI remained unchanged. The use of NIR to modulate symptoms associated with RLS was supported by the data.

  17. Loss restlessness and gain calmness: durable effects of losses and gains on choice switching.

    PubMed

    Yechiam, Eldad; Zahavi, Gal; Arditi, Eli

    2015-08-01

    While the traditional conceptualization of the effect of losses focuses on bias in the subjective weight of losses compared with respective gains, some accounts suggest more global task-related effects of losses. Based on a recent attentional theory, we predicted a positive after-effect of losses on choice switching in later tasks. In two experimental studies, we found increased choice switching rates in tasks with losses compared to tasks with no losses. Additionally, this heightened shifting behavior was maintained in subsequent tasks that do not include losses, a phenomenon we refer to as "loss restlessness." Conversely, gains were found to have an opposite "calming" effect on choice switching. Surprisingly, the loss restlessness phenomenon was observed following an all-losses payoff regime but not after a task with symmetric mixed gains and losses. This suggests that the unresolved mental account following an all-losses regime increases search behavior. Potential implications to macro level phenomena, such as the leverage effect, are discussed.

  18. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children.

    PubMed

    Müller, S F; Klement, S

    2006-06-01

    Efficacy and tolerability of a combined valerian/lemon balm preparation were investigated in an open, multicentre study in children less than 12 years suffering from restlessness and nervous dyskoimesis. Patients were dosed individually by the investigators. In total, 918 children were evaluated for therapeutic efficacy and tolerability. A distinct and convincing reduction in severity was found for all symptoms in the investigators' and parents' ratings. The core symptoms dyssomnia and restlessness were reduced from "moderate/severe" to "mild" or "absent" in most of the patients. In total, 80.9% of the patients who suffered from dyssomnia experienced an improvement for this symptom and 70.4% of the patients with restlessness improved clearly. For the other listed symptoms the total improvement was 37.8% on average. Both, parents and investigators assessed efficacy as to be "very good" or "good" (60.5% and 67.7%, respectively). The tolerability of Euvegal forte was considered as "good" (in 96.7% of the patients it was judged to be "very good" or "good"). No study medication-related adverse events occurred. In conclusion, Euvegal forte was effective in the treatment of younger children with restlessness and dyssomnia and it was very well tolerated.

  19. Thomas de Quincey and his restless legs symptoms as depicted in "Confessions of an English Opium-Eater".

    PubMed

    Miranda, Marcelo; Williams, Anne-Marie; Garcia-Borreguero, Diego

    2010-10-15

    Thomas de Quincey, a British writer of 19th century, suffered insomnia from the age of 17 years. In his famous "Confessions of an English-Opium Eater" (1822), he described a symptomatology that could concord with restless legs syndrome long before he became addicted to opium. In this report, we analyze his clinical description and the circumstances leading to his opium addiction.

  20. Aerobic Exercise Improves Signs of Restless Leg Syndrome in End Stage Renal Disease Patients Suffering Chronic Hemodialysis

    PubMed Central

    Mortazavi, Mojgan; Vahdatpour, Babak; Ghasempour, Aida; Taheri, Diana; Shahidi, Shahrzad; Moeinzadeh, Firouzeh; Dolatkhah, Bahareh; Dolatkhah, Shahaboddin

    2013-01-01

    Background. Restless leg syndrome (RLS) is one of the prevalent complaints of patients with end stage renal diseases suffering chronic hemodialysis. Although there are some known pharmacological managements for this syndrome, the adverse effect of drugs causes a limitation for using them. In this randomized clinical trial we aimed to find a nonpharmacological way to improve signs of restless leg syndrome and patients' quality of life. Material and Methods. Twenty-six patients were included in the study and divided into 2 groups of control and exercise. The exercise group used aerobic exercise during their hemodialysis for 16 weeks. The quality of life and severity of restless leg syndrome were assessed at the first week of study and final week. Data were analyzed using SPSS software. Results. The difference of means of RLS signs at the first week of study and final week was −5.5 ± 4.96 in exercise group and −0.53 ± 2.3 in control group. There was not any statistical difference between control group and exercise group in quality of life at the first week of study and final week. Conclusions. We suggest using aerobic exercise for improving signs of restless leg syndrome, but no evidence was found for its efficacy on patient's quality of life. PMID:24307876

  1. Quiescence in Artemia franciscana embryos: reversible arrest of metabolism and gene expression at low oxygen levels.

    PubMed

    Hand, S C

    1998-04-01

    Depression of the production and consumption of cellular energy appears to be a prerequisite for the survival of prolonged bouts of anoxia. A correlation exists between the degree of metabolic depression under anoxia and the duration of anoxia tolerance. In the case of brine shrimp (Artemia franciscana) embryos, oxygen deprivation induces a reversible quiescent state that can be tolerated for several years with substantial survivorship. A global arrest of cytoplasmic translation accompanies the transition into anoxia, and rates of protein synthesis in mitochondria from these embryos appears to be markedly reduced in response to anoxia. Previous evidence suggests that the acute acidification of intracellular pH (pHi) by over 1.0 unit during the transition into anoxia contributes to the depression of biosynthesis, but message limitation does not appear to play a role in the down-regulation in either cellular compartment. The ontogenetic increase in mRNA levels for a mitochondrial-encoded subunit of cytochrome c oxidase (COX I) and for nuclear-encoded actin is blocked by anoxia and aerobic acidosis (artificial quiescence imposed by intracellular acidification under aerobic conditions). Further, the levels of COX I and actin mRNA do not decline appreciably during 6 h bouts of quiescence, even though protein synthesis is acutely arrested across this same period. Thus, the constancy of mRNA levels during quiescence indicates that reduced protein synthesis is not caused by message limitation but, instead, is probably controlled at the translational level. This apparent stabilization of mRNA under anoxia is mirrored in an extension of protein half-life. The ubiquitin-dependent pathway for protein degradation is depressed under anoxia and aerobic acidosis, as judged by the acute drop in levels of ubiquitin-conjugated proteins. Mitochondrial protein synthesis is responsive to both acidification of pHi and removal of oxygen per se. Matrix pH declines in parallel with pHi, and

  2. FRPR-4 Is a G-Protein Coupled Neuropeptide Receptor That Regulates Behavioral Quiescence and Posture in Caenorhabditis elegans

    PubMed Central

    York, Neil; Lee, Kun He; Schoofs, Liliane; Raizen, David M.

    2015-01-01

    Neuropeptides signal through G-protein coupled receptors (GPCRs) to regulate a broad array of animal behaviors and physiological processes. The Caenorhabditis elegans genome encodes approximately 100 predicted neuropeptide receptor GPCRs, but in vivo roles for only a few have been identified. We describe here a role for the GPCR FRPR-4 in the regulation of behavioral quiescence and locomotive posture. FRPR-4 is activated in cell culture by several neuropeptides with an amidated isoleucine-arginine-phenylalanine (IRF) motif or an amidated valine-arginine-phenylalanine (VRF) motif at their carboxy termini, including those encoded by the gene flp-13. Loss of frpr-4 function results in a minor feeding quiescence defect after heat-induced cellular stress. Overexpression of frpr-4 induces quiescence of locomotion and feeding as well as an exaggerated body bend posture. The exaggerated body bend posture requires the gene flp-13. While frpr-4 is expressed broadly, selective overexpression of frpr-4 in the proprioceptive DVA neurons results in exaggerated body bends that require flp-13 in the ALA neuron. Our results suggest that FLP-13 and other neuropeptides signal through FRPR-4 and other receptors to regulate locomotion posture and behavioral quiescence. PMID:26571132

  3. Uropathogenic Escherichia coli Metabolite-Dependent Quiescence and Persistence May Explain Antibiotic Tolerance during Urinary Tract Infection

    PubMed Central

    Leatham-Jensen, Mary P.; Mokszycki, Matthew E.; Rowley, David C.; Deering, Robert; Camberg, Jodi L.; Sokurenko, Evgeni V.; Tchesnokova, Veronika L.; Frimodt-Møller, Jakob; Leth Nielsen, Karen; Sun, Gongqin

    2016-01-01

    ABSTRACT In the present study, it is shown that although Escherichia coli CFT073, a human uropathogenic (UPEC) strain, grows in liquid glucose M9 minimal medium, it fails to grow on glucose M9 minimal medium agar plates seeded with ≤106 CFU. The cells on glucose plates appear to be in a “quiescent” state that can be prevented by various combinations of lysine, methionine, and tyrosine. Moreover, the quiescent state is characteristic of ~80% of E. coli phylogenetic group B2 multilocus sequence type 73 strains, as well as 22.5% of randomly selected UPEC strains isolated from community-acquired urinary tract infections in Denmark. In addition, E. coli CFT073 quiescence is not limited to glucose but occurs on agar plates containing a number of other sugars and acetate as sole carbon sources. It is also shown that a number of E. coli CFT073 mini-Tn5 metabolic mutants (gnd, gdhA, pykF, sdhA, and zwf) are nonquiescent on glucose M9 minimal agar plates and that quiescence requires a complete oxidative tricarboxylic acid (TCA) cycle. In addition, evidence is presented that, although E. coli CFT073 quiescence and persistence in the presence of ampicillin are alike in that both require a complete oxidative TCA cycle and each can be prevented by amino acids, E. coli CFT073 quiescence occurs in the presence or absence of a functional rpoS gene, whereas maximal persistence requires a nonfunctional rpoS. Our results suggest that interventions targeting specific central metabolic pathways may mitigate UPEC infections by interfering with quiescence and persistence. IMPORTANCE Recurrent urinary tract infections (UTIs) affect 10 to 40% of women. In up to 77% of those cases, the recurrent infections are caused by the same uropathogenic E. coli (UPEC) strain that caused the initial infection. Upon infection of urothelial transitional cells in the bladder, UPEC appear to enter a nongrowing quiescent intracellular state that is thought to serve as a reservoir responsible

  4. Failure of a Neutrino-driven Explosion after Core-collapse May Lead to a Thermonuclear Supernova

    NASA Astrophysics Data System (ADS)

    Kushnir, Doron; Katz, Boaz

    2015-10-01

    We demonstrate that ∼10 s after the core-collapse of a massive star, a thermonuclear explosion of the outer shells is possible for some (tuned) initial density and composition profiles, assuming that the neutrinos failed to explode the star. The explosion may lead to a successful supernova, as first suggested by Burbidge et al. We perform a series of one-dimensional (1D) calculations of collapsing massive stars with simplified initial density profiles (similar to the results of stellar evolution calculations) and various compositions (not similar to 1D stellar evolution calculations). We assume that the neutrinos escaped with a negligible effect on the outer layers, which inevitably collapse. As the shells collapse, they compress and heat up adiabatically, enhancing the rate of thermonuclear burning. In some cases, where significant shells of mixed helium and oxygen are present with pre-collapsed burning times of ≲100 s (≈10 times the free-fall time), a thermonuclear detonation wave is ignited, which unbinds the outer layers of the star, leading to a supernova. The energy released is small, ≲1050 erg, and negligible amounts of synthesized material (including 56Ni) are ejected, implying that these 1D simulations are unlikely to represent typical core-collapse supernovae. However, they do serve as a proof of concept that the core-collapse-induced thermonuclear explosions are possible, and more realistic two-dimensional and three-dimensional simulations are within current computational capabilities.

  5. FAILURE OF A NEUTRINO-DRIVEN EXPLOSION AFTER CORE-COLLAPSE MAY LEAD TO A THERMONUCLEAR SUPERNOVA

    SciTech Connect

    Kushnir, Doron; Katz, Boaz

    2015-10-01

    We demonstrate that ∼10 s after the core-collapse of a massive star, a thermonuclear explosion of the outer shells is possible for some (tuned) initial density and composition profiles, assuming that the neutrinos failed to explode the star. The explosion may lead to a successful supernova, as first suggested by Burbidge et al. We perform a series of one-dimensional (1D) calculations of collapsing massive stars with simplified initial density profiles (similar to the results of stellar evolution calculations) and various compositions (not similar to 1D stellar evolution calculations). We assume that the neutrinos escaped with a negligible effect on the outer layers, which inevitably collapse. As the shells collapse, they compress and heat up adiabatically, enhancing the rate of thermonuclear burning. In some cases, where significant shells of mixed helium and oxygen are present with pre-collapsed burning times of ≲100 s (≈10 times the free-fall time), a thermonuclear detonation wave is ignited, which unbinds the outer layers of the star, leading to a supernova. The energy released is small, ≲10{sup 50} erg, and negligible amounts of synthesized material (including {sup 56}Ni) are ejected, implying that these 1D simulations are unlikely to represent typical core-collapse supernovae. However, they do serve as a proof of concept that the core-collapse-induced thermonuclear explosions are possible, and more realistic two-dimensional and three-dimensional simulations are within current computational capabilities.

  6. Spreading of thermonuclear flames on the neutron star in SAX J1808.4-3658: an observational tool

    NASA Technical Reports Server (NTRS)

    Bhattacharyya, Sudip; Strohmayer, Tod E.

    2005-01-01

    We analyse archival Rossi X-Ray Timing Explorer (RXTE) proportional counter array (PCA) data of thermonuclear X-ray bursts from the 2002 outburst of the accreting millisecond pulsar SAX 51808.4-3658. We present evidence of a complex frequency modulation of oscillations during burst rise, and correlations among the time evolution of the oscillation frequency, amplitude, and the inferred burning region area. We discuss these findings in the context of a model, based on thermonuclear flame spreading on the neutron star surface, that can qualitatively explain these features. From our model, we infer that for the 2002 Oct. 15 thermonuclear burst, the ignition likely occurred in the mid-latitudes, the burning region took approx. 0.2 s to nearly encircle the equatorial region of the neutron star, and after that the lower amplitude oscillation originated from the remaining asymmetry of the burning front in the same hemisphere where the burst ignited. We emphasize that studies of the evolution of burst oscillation properties during burst rise can provide a powerful tool to understand thermonuclear flame spreading on neutron star surfaces under extreme physical conditions.

  7. APPLICATIONS OF LASERS AND OTHER TOPICS IN LASER PHYSICS AND TECHNOLOGY: Hybrid reactor based on laser thermonuclear fusion

    NASA Astrophysics Data System (ADS)

    Basov, N. G.; Belousov, N. I.; Grishunin, P. A.; Kalmykov, Yu K.; Lebo, I. G.; Rozanov, Vladislav B.; Sklizkov, G. V.; Subbotin, V. I.; Finkel'shteĭn, K. I.; Kharitonov, V. V.; Sherstnev, K. B.

    1987-10-01

    A physicotechnical and parametric analysis is used as the basis for a conceptual design of a thermonuclear inertial-confinement hybrid reactor as a breeder of fuel for fission nuclear power stations. It is proposed to use a laser as a driver in this reactor.

  8. EFFECT OF LASER LIGHT ON MATTER. LASER PLASMAS: Films containing heavy hydrogen isotopes in laser thermonuclear fusion targets

    NASA Astrophysics Data System (ADS)

    Abramov, Yu A.; Bessarab, A. V.; Veselov, A. V.; Gavrilov, P. I.; Druzhinin, A. A.; Izgorodin, V. M.; Karel'skaya, T. V.; Kirillov, G. A.; Komleva, G. V.; Lyamin, G. A.; Nikolaev, G. P.; Pinegin, A. V.; Punin, V. T.; Rabinovich, K. G.; Romaev, V. N.; Rogachev, V. G.; Solomatina, E. Yu; Tarasova, N. N.; Tachaev, G. V.; Andryushin, V. V.; Emel'yanov, S. A.; Kryuchenkov, V. B.; Markelov, N. N.; Markushkin, Yu E.; Chirin, N. A.

    1994-02-01

    An investigation was made of fuel films in targets used in experiments on laser thermonuclear fusion in Iskra-4 and Iskra-5 systems. These films were formed from condensed deuterium and a deuterium—tritium mixture, and also from metal hydrides and polyethylene containing deuterium and tritium.

  9. Regulation of plant stem cell quiescence by a brassinosteroid signaling module.

    PubMed

    Vilarrasa-Blasi, Josep; González-García, Mary-Paz; Frigola, David; Fàbregas, Norma; Alexiou, Konstantinos G; López-Bigas, Nuria; Rivas, Susana; Jauneau, Alain; Lohmann, Jan U; Benfey, Philip N; Ibañes, Marta; Caño-Delgado, Ana I

    2014-07-14

    The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CENTER), acting as a cell-specific repressor of QC divisions in the primary root of Arabidopsis. Ectopic BRAVO expression restricts overall root growth and ceases root regeneration upon damage of the stem cells, demonstrating the role of BRAVO in counteracting Brassinosteroid (BR)-mediated cell division in the QC cells. Interestingly, BR-regulated transcription factor BES1 (BRI1-EMS SUPRESSOR 1) directly represses and physically interacts with BRAVO in vivo, creating a switch that modulates QC divisions at the root stem cell niche. Together, our results define a mechanism for BR-mediated regulation of stem cell quiescence in plants.

  10. Timing of Transcriptional Quiescence during Gametogenesis Is Controlled by Global Histone H3K4 Demethylation

    PubMed Central

    Xu, Mengshu; Soloveychik, Maria; Ranger, Mathieu; Schertzberg, Michael; Shah, Zarna; Raisner, Ryan; Venkatasubrahmanyan, Shivkumar; Tsui, Kyle; Gebbia, Marinella; Hughes, Tim; van Bakel, Harm; Nislow, Corey; Madhani, Hiten D.; Meneghini, Marc D.

    2013-01-01

    SUMMARY Gametes are among the most highly specialized cells produced during development. Although gametogenesis culminates in transcriptional quiescence in plants and animals, regulatory mechanisms controlling this are unknown. Here, we confirm that gamete differentiation in the single-celled yeast Saccharomyces cerevisiae is accompanied by global transcriptional shutoff following the completion of meiosis. We show that Jhd2, a highly conserved JARID1-family histone H3K4 demethylase, activates protein-coding gene transcription in opposition to this programmed transcriptional shutoff, sustaining the period of productive transcription during spore differentiation. Moreover, using genome-wide nucleosome, H3K4me, and transcript mapping experiments, we demonstrate that JHD2 globally represses intergenic noncoding transcription during this period. The widespread transcriptional defects of JHD2 mutants are associated with precocious differentiation and the production of stress-sensitive spores, demonstrating that Jhd2 regulation of the global postmeiotic transcriptional program is critical for the production of healthy meiotic progeny. PMID:23123093

  11. Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation.

    PubMed

    Xu, Mengshu; Soloveychik, Maria; Ranger, Mathieu; Schertzberg, Michael; Shah, Zarna; Raisner, Ryan; Venkatasubrahmanyan, Shivkumar; Tsui, Kyle; Gebbia, Marinella; Hughes, Tim; van Bakel, Harm; Nislow, Corey; Madhani, Hiten D; Meneghini, Marc D

    2012-11-13

    Gametes are among the most highly specialized cells produced during development. Although gametogenesis culminates in transcriptional quiescence in plants and animals, regulatory mechanisms controlling this are unknown. Here, we confirm that gamete differentiation in the single-celled yeast Saccharomyces cerevisiae is accompanied by global transcriptional shutoff following the completion of meiosis. We show that Jhd2, a highly conserved JARID1-family histone H3K4 demethylase, activates protein-coding gene transcription in opposition to this programmed transcriptional shutoff, sustaining the period of productive transcription during spore differentiation. Moreover, using genome-wide nucleosome, H3K4me, and transcript mapping experiments, we demonstrate that JHD2 globally represses intergenic noncoding transcription during this period. The widespread transcriptional defects of JHD2 mutants are associated with precocious differentiation and the production of stress-sensitive spores, demonstrating that Jhd2 regulation of the global postmeiotic transcriptional program is critical for the production of healthy meiotic progeny.

  12. Long-Term Seismic Quiescences and Great Earthquakes in and Around the Japan Subduction Zone Between 1975 and 2012

    NASA Astrophysics Data System (ADS)

    Katsumata, Kei

    2016-10-01

    An earthquake catalog created by the International Seismological Center (ISC) was analyzed, including 3898 earthquakes located in and around Japan between January 1964 and June 2012 shallower than 60 km with the body wave magnitude of 5.0 or larger. Clustered events such as earthquake swarms and aftershocks were removed from the ISC catalog by using a stochastic declustering method based on Epidemic-Type Aftershock Sequence (ETAS) model. A detailed analysis of the earthquake catalog using a simple scanning technique (ZMAP) shows that the long-term seismic quiescences lasting more than 9 years were recognized ten times along the subduction zone in and around Japan. The three seismic quiescences among them were followed by three great earthquakes: the 1994 Hokkaido-toho-oki earthquake (M w 8.3), the 2003 Tokachi-oki earthquake (M w 8.3), and the 2011 Tohoku earthquake (M w 9.0). The remaining seven seismic quiescences were followed by no earthquake with the seismic moment M 0 ≥ 3.0 × 1021 Nm (M w 8.25), which are candidates of the false alarm. The 2006 Kurile Islands earthquake (M w 8.3) was not preceded by the significant seismic quiescence, which is a case of the surprise occurrence. As a result, when limited to earthquakes with the seismic moment of M 0 ≥ 3.0 × 1021 Nm, four earthquakes occurred between 1976 and 2012 in and around Japan, and three of them were preceded by the long-term seismic quiescence lasting more than 9 years.

  13. The black hole binary V4641 Sagitarii: Activity in quiescence and improved mass determinations

    SciTech Connect

    MacDonald, Rachel K. D.; Bailyn, Charles D.; Buxton, Michelle; Cantrell, Andrew G.; Chatterjee, Ritaban; Kennedy-Shaffer, Ross; Orosz, Jerome A.; Markwardt, Craig B.; Swank, Jean H.

    2014-03-20

    We examine ∼10 yr of photometric data and find that the black hole X-ray binary V4641 Sgr has two optical states, passive and active, during X-ray quiescence. The passive state is dominated by ellipsoidal variations and is stable in the shape and variability of the light curve. The active state is brighter and more variable. Emission during the active state varies over the course of the orbital period and is redder than the companion star. These optical/infrared states last for weeks or months. V4641 Sgr spends approximately 85% of X-ray quiescence in the passive state and 15% in the active. We analyze passive colors and spectroscopy of V4641 Sgr and show that they are consistent with a reddened B9III star (with E(B – V) = 0.37 ± 0.19) with little or no contribution from the accretion disk. We use X-ray observations with an updated ephemeris to place an upper limit on the duration of an X-ray eclipse of <8.°3 in phase (∼1.6 hr). High-resolution spectroscopy yields a greatly improved measurement of the rotational velocity of the companion star of V {sub rot}sin i = 100.9 ± 0.8 km s{sup –1}. We fit ellipsoidal models to the passive state data and find an inclination angle of i = 72.3 ± 4.°1, a mass ratio of Q = 2.2 ± 0.2, and component masses for the system of M {sub BH} = 6.4 ± 0.6 M {sub ☉} and M {sub 2} = 2.9 ± 0.4 M {sub ☉}. Using these values we calculate an updated distance to V4641 Sgr of 6.2 ± 0.7 kpc.

  14. Early Cenozoic tectonic quiescence at the southern Levant continental margin, eastern Mediterranean

    NASA Astrophysics Data System (ADS)

    Schattner, Uri; Segev, Amit; Lyakhovsky, Vladimir

    2010-05-01

    The geological record of the easternmost Mediterranean shows almost continuous tectonic activity across the Levant continental margin since its formation during the early Mesozoic until the Recent. The margin developed as part of the Gondwana super continent breakup. Since mid Cenozoic onwards Gondwana descendants, the African and Arabian plates, progressively collided with Eurasia. This collision along with the initiation activity of the Afar plume led to the Cenozoic reactivation of the Levant margin. We explore the geodynamic development of the Levant region between its formation and reactivation through one of the poorly understood time periods in its history. Geological evidence shows that tectonomagmatic processes associated with the formation of the Levant margin and later geodynamic events lasted until the Maastrichtian. During the following ~25 Myr exclusively, thick pelagic and deep sea sediments accumulated on the submerged northwestern Arabian plate. We interpret this early-to-middle Paleogene time window as a unique interval of tectonic and magmatic quiescence. During this mature post continental, breakup stage, thermal equilibrium and isostatic compensation were achieved. A three-dimensional layered lithosphere model was constructed to describe this Middle-Late Eocene geodynamic scene of the Levant area before its reactivation. Layers of the model include the Moho, top of the basement interfaces and the top Avedat Group (Upper Eocene) interfaces. The model was established after a 100 km horizontal restoration along the Dead Sea transform and vertical correction by isostatic compensation to achieve the paleo structure which prevailed in the study area at the end of the Eocene. The reconstructed elevation defines a ramp-shaped structure compatible with independent geological evidence. Results show that most parts of the central Levant margin were submerged ~200 m to ~1800 m, while the paleo bathymetric slopes ranged from ~2° (shelf) to ~6° (slope

  15. From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle.

    PubMed

    Gérard, Claude; Goldbeter, Albert

    2012-01-01

    We recently proposed a detailed model describing the dynamics of the network of cyclin-dependent kinases (Cdks) driving the mammalian cell cycle (Gérard and Goldbeter, 2009). The model contains four modules, each centered around one cyclin/Cdk complex. Cyclin D/Cdk4-6 and cyclin E/Cdk2 promote progression in G1 and elicit the G1/S transition, respectively; cyclin A/Cdk2 ensures progression in S and the transition S/G2, while the activity of cyclin B/Cdk1 brings about the G2/M transition. This model shows that in the presence of sufficient amounts of growth factor the Cdk network is capable of temporal self-organization in the form of sustained oscillations, which correspond to the ordered, sequential activation of the various cyclin/Cdk complexes that control the successive phases of the cell cycle. The results suggest that the switch from cellular quiescence to cell proliferation corresponds to the transition from a stable steady state to sustained oscillations in the Cdk network. The transition depends on a finely tuned balance between factors that promote or hinder progression in the cell cycle. We show that the transition from quiescence to proliferation can occur in multiple ways that alter this balance. By resorting to bifurcation diagrams, we analyze the mechanism of oscillations in the Cdk network. Finally, we show that the complexity of the detailed model can be greatly reduced, without losing its key dynamical properties, by considering a skeleton model for the Cdk network. Using such a skeleton model for the mammalian cell cycle we show that positive feedback (PF) loops enhance the amplitude and the robustness of Cdk oscillations with respect to molecular noise. We compare the relative merits of the detailed and skeleton versions of the model for the Cdk network driving the mammalian cell cycle.

  16. A photometric study of the eclipsing dwarf nova GY Cnc in quiescence and during an outburst

    NASA Astrophysics Data System (ADS)

    Khruzina, T. S.; Voloshina, I. B.; Metlov, V. G.

    2016-11-01

    The results of photometric observations of the dwarf nova GY Cnc in the Rc filter acquired in 2013-2015 ( 3900 orbital cycles, 19 nights in total) are presented, including observations during its outburst in April 2014. The binary's orbital elements have been refined. The orbital period has changed only insignificantly during the 30 000 P orb since the earlier observations; no systematic O-C variations were detected, only fluctuations within 0.004d on time scales of 1500-2000 P orb. A "combined" model is used to solve for the parameters of GY Cnc during two states of the system. The flux from the white dwarf is negligible due to the star's small size. The temperature of the donor star, T 2 3667 K (Sp M0.2 V), varies between 3440 and 3900 K (Sp K8.8-M1.7 V). The semi-major axis of the disk is a 0.22a0, on average. In quiescence, a varies within 40%. The disk has a considerable eccentricity ( e 0.2-0.3) for a < 0.2a0. The disk shape becomes more circular ( e < 0.1) with increasing a. The outburst of GY Cnc was associated with increased luminosity of the disk due to the parameter α g (related to the viscosity of the disk material) decreasing to 0.1-0.2 and the temperature in the inner parts of the disk increasing twofold, to T in 95 000 K. These changes were apparently due to the infall of matter onto the surface of the white dwarf as the outburst developed. All parameters of the accretion disk in quiescence display considerable variations about their mean values.

  17. The Black Hole Binary V4641 Sagitarii: Activity in Quiescence and Improved Mass Determinations

    NASA Astrophysics Data System (ADS)

    MacDonald, Rachel K. D.; Bailyn, Charles D.; Buxton, Michelle; Cantrell, Andrew G.; Chatterjee, Ritaban; Kennedy-Shaffer, Ross; Orosz, Jerome A.; Markwardt, Craig B.; Swank, Jean H.

    2014-03-01

    We examine ~10 yr of photometric data and find that the black hole X-ray binary V4641 Sgr has two optical states, passive and active, during X-ray quiescence. The passive state is dominated by ellipsoidal variations and is stable in the shape and variability of the light curve. The active state is brighter and more variable. Emission during the active state varies over the course of the orbital period and is redder than the companion star. These optical/infrared states last for weeks or months. V4641 Sgr spends approximately 85% of X-ray quiescence in the passive state and 15% in the active. We analyze passive colors and spectroscopy of V4641 Sgr and show that they are consistent with a reddened B9III star (with E(B - V) = 0.37 ± 0.19) with little or no contribution from the accretion disk. We use X-ray observations with an updated ephemeris to place an upper limit on the duration of an X-ray eclipse of <8.°3 in phase (~1.6 hr). High-resolution spectroscopy yields a greatly improved measurement of the rotational velocity of the companion star of V rotsin i = 100.9 ± 0.8 km s-1. We fit ellipsoidal models to the passive state data and find an inclination angle of i = 72.3 ± 4.°1, a mass ratio of Q = 2.2 ± 0.2, and component masses for the system of M BH = 6.4 ± 0.6 M ⊙ and M 2 = 2.9 ± 0.4 M ⊙. Using these values we calculate an updated distance to V4641 Sgr of 6.2 ± 0.7 kpc.

  18. Quiescence does not affect p53 and stress response by irradiation in human lung fibroblasts

    SciTech Connect

    Dai, Jiawen; Itahana, Koji; Baskar, Rajamanickam

    2015-02-27

    Cells in many organs exist in both proliferating and quiescent states. Proliferating cells are more radio-sensitive, DNA damage pathways including p53 pathway are activated to undergo either G{sub 1}/S or G{sub 2}/M arrest to avoid entering S and M phase with DNA damage. On the other hand, quiescent cells are already arrested in G{sub 0}, therefore there may be fundamental difference of irradiation response between proliferating and quiescent cells, and this difference may affect their radiosensitivity. To understand these differences, proliferating and quiescent human normal lung fibroblasts were exposed to 0.10–1 Gy of γ-radiation. The response of key proteins involved in the cell cycle, cell death, and metabolism as well as histone H2AX phosphorylation were examined. Interestingly, p53 and p53 phosphorylation (Ser-15), as well as the cyclin-dependent kinase inhibitors p21 and p27, were induced similarly in both proliferating and quiescent cells after irradiation. Furthermore, the p53 protein half-life, and expression of cyclin A, cyclin E, proliferating cell nuclear antigen (PCNA), Bax, or cytochrome c expression as well as histone H2AX phosphorylation were comparable after irradiation in both phases of cells. The effect of radioprotection by a glycogen synthase kinase 3β inhibitor on p53 pathway was also similar between proliferating and quiescent cells. Our results showed that quiescence does not affect irradiation response of key proteins involved in stress and DNA damage at least in normal fibroblasts, providing a better understanding of the radiation response in quiescent cells, which is crucial for tissue repair and regeneration. - Highlights: • p53 response by irradiation was similar between proliferating and quiescent cells. • Quiescent cells showed similar profiles of cell cycle proteins after irradiation. • Radioprotection of GSK-3β inhibitor caused similar effects between these cells. • Quiescence did not affect p53 response despite its

  19. The development and the tests of the electrostatic probe for dust particle collection in thermonuclear reactors

    NASA Astrophysics Data System (ADS)

    Begrambekov, L. B.; Voityuk, A. N.; Zakharov, A. M.

    2016-09-01

    Formation of dust particles in thermonuclear reactors can greatly affect the plasma parameters and lead to accumulation of tritium. The rates of formation and deposition of dust need to be measured, and the parameters of formation of dust particles and clusters need to be studied. A model of a device for collection of fine conductive particles capable of removing them from the reactor chamber for future research is proposed in this paper. The dust collector's operation is based on a principle of applied electrostatic field. The model was tested in different operating conditions: in vacuum, at the atmospheric pressure in the atmosphere of air and dry nitrogen. The experiments were conducted with a stationary system and with the dust collector in motion relative to the dusty surface. It is shown that, during the probe moving relative to the surface, it can remove up to 95% of fine tungsten particles with sizes ranging from 1 to 10 μm.

  20. ITER (International Thermonuclear Experimental Reactor) shield and blanket work package report

    SciTech Connect

    Not Available

    1988-06-01

    This report summarizes nuclear-related work in support of the US effort for the International Thermonuclear Experimental Reactor (ITER) Study. The purpose of this work was to prepare for the first international ITER workshop devoted to defining a basic ITER concept that will serve as a basis for an indepth conceptual design activity over the next 2-1/2 years. Primary tasks carried out during the past year included: design improvements of the inboard shield developed for the TIBER concept, scoping studies of a variety of tritium breeding blanket options, development of necessary design guidelines and evaluation criteria for the blanket options, further safety considerations related to nuclear components and issues regarding structural materials for an ITER device. 44 refs., 31 figs., 29 tabs.

  1. Review of the International Thermonuclear Experimental Reactor (ITER) detailed design report

    SciTech Connect

    1997-04-18

    Dr. Martha Krebs, Director, Office of Energy Research at the US Department of Energy (DOE), wrote to the Fusion Energy Sciences Advisory Committee (FESAC), in letters dated September 23 and November 6, 1996, requesting that FESAC review the International Thermonuclear Experimental Reactor (ITER) Detailed Design Report (DDR) and provide its view of the adequacy of the DDR as part of the basis for the United States decision to enter negotiations with the other interested Parties regarding the terms and conditions for an agreement for the construction, operations, exploitation and decommissioning of ITER. The letter from Dr. Krebs, referred to as the Charge Letter, provided context for the review and a set of questions of specific interest.

  2. SPIRAL INSTABILITY CAN DRIVE THERMONUCLEAR EXPLOSIONS IN BINARY WHITE DWARF MERGERS

    SciTech Connect

    Kashyap, Rahul; Fisher, Robert; García-Berro, Enrique; Aznar-Siguán, Gabriela; Lorén-Aguilar, Pablo

    2015-02-10

    Thermonuclear, or Type Ia supernovae (SNe Ia), originate from the explosion of carbon–oxygen white dwarfs, and serve as standardizable cosmological candles. However, despite their importance, the nature of the progenitor systems that give rise to SNe Ia has not been hitherto elucidated. Observational evidence favors the double-degenerate channel in which merging white dwarf binaries lead to SNe Ia. Furthermore, significant discrepancies exist between observations and theory, and to date, there has been no self-consistent merger model that yields a SNe Ia. Here we show that a spiral mode instability in the accretion disk formed during a binary white dwarf merger leads to a detonation on a dynamical timescale. This mechanism sheds light on how white dwarf mergers may frequently yield SNe Ia.

  3. VizieR Online Data Catalog: Models of thermonuclear X-ray bursters (Lampe+, 2016)

    NASA Astrophysics Data System (ADS)

    Lampe, N.; Heger, A.; Galloway, D. K.

    2016-05-01

    Using the KEPLER 1D hydrodynamics code (Woosley et al. 2004ApJS..151...75W), 464 models of thermonuclear X-ray bursters were performed across a range of accretion rates and compositions. We present the library of simulated burst profiles from this sample, and examine variations in the simulated light curve for different model conditions. We find that the recurrence time varies as a power law against accretion rate, and measure its slope while mixed H/He burning is occurring for a range of metallicities, finding the power law gradient to vary from {eta}=1.1 to 1.24. We identify the accretion rates at which mixed H/He burning stops and a transition occurs to different burning regimes. We explore how varying the accretion rate and metallicity affects burst morphology in both the rise and tail. (1 data file).

  4. The Influence of Accretion Rate and Metallicity on Thermonuclear Bursts: Predictions from KEPLER Models

    NASA Astrophysics Data System (ADS)

    Lampe, Nathanael; Heger, Alexander; Galloway, Duncan K.

    2016-03-01

    Using the KEPLER hydrodynamics code, 464 models of thermonuclear X-ray bursters were performed across a range of accretion rates and compositions. We present the library of simulated burst profiles from this sample, and examine variations in the simulated light curve for different model conditions. We find that the recurrence time varies as a power law against accretion rate, and measure its slope while mixed H/He burning is occurring for a range of metallicities, finding the power law gradient to vary from η =1.1 to 1.24. We identify the accretion rates at which mixed H/He burning stops and a transition occurs to different burning regimes. We explore how varying the accretion rate and metallicity affects burst morphology in both the rise and tail.

  5. Annual report of the Summit Members' Working Group on Controlled Thermonuclear Fusion (Fusin Working Group (FWG))

    SciTech Connect

    none,

    1987-04-01

    The Summit Members' Working Group on Controlled Thermonuclear Fusion (Fusion Working Group (FWG)) was established in 1983 in response to the Declaration of the Heads of State and Government at the Versailles Economic Summit meeting of 1982, and in response to the subsequent report of the Working Group in Technology, Growth and Employment (TGE) as endorsed at the Williamsburg Summit meeting, 1983. This document contains the complete written record of each of the three FWG meetings which include the minutes, lists of attendees, agendas, statements, and summary conclusions as well as the full reports of the Technical Working Party. In addition, there is a pertinent exchange of correspondence between FWG members on the role of the Technical Working Party and a requested background paper on the modalities associated with a possible future ETR project.

  6. Astrophysics Simulations from the ASC/Alliances Center for Astrophysical Thermonuclear Flashes

    DOE Data Explorer

    The "Flash Center" works to solve the long-standing problem of thermonuclear flashes on the surfaces of compact stars such as neutron stars and white dwarfs, and in the interior of white dwarfs (i.e., Type I supernovae). The physical conditions, and many of the physical phenomena, are similar to those confronted by the Department of Energy Stockpile Stewardship program. The (fully ionized) plasmas are at very high temperatures and densities; and the physical problems of nuclear ignition, deflagration or detonation, turbulent mixing, and interface dynamics for complex multicomponent fluids are common to the weapons program. Because virtually every aspect of this problem represents a computational Grand Challenge, large-scale numerical simulations are at the heart of its resolution (Taken from Executive Summary page). More than 35 simulations and computer animations developed through research at the "Flash Center" are available here. The collection offers .avi, .flv, or .mpeg file downloads as well as references to related research papers or presentations.

  7. Masses And Radii Of Neutron Stars Measured From Thermonuclear X-ray Bursts

    NASA Astrophysics Data System (ADS)

    Guver, Tolga; Ozel, F.

    2011-09-01

    Low mass X-ray binaries that show thermonuclear bursts are ideal targets for constraining the equation of state of neutron star matter. The analysis of the time resolved, high count rate X-ray spectra allow a measurement of the Eddington limits and the apparent radii of neutron stars. Combined with an independent distance estimate, these spectroscopic quantities lead to the measurement of neutron star masses and radii. I will discuss the results of the application of this method to a number of X-ray binaries including EXO 1745-248, 4U 1820-30, 4U 1608-52,KS 1731-260, and SAX J1748.9-2021. I will also present the results from a comprehensive analysis of the entire RXTE archive of X-ray burst observations, which allows for a better quantification of the systematic uncertainties in these measurements.

  8. Stellar dynamics. The fastest unbound star in our Galaxy ejected by a thermonuclear supernova.

    PubMed

    Geier, S; Fürst, F; Ziegerer, E; Kupfer, T; Heber, U; Irrgang, A; Wang, B; Liu, Z; Han, Z; Sesar, B; Levitan, D; Kotak, R; Magnier, E; Smith, K; Burgett, W S; Chambers, K; Flewelling, H; Kaiser, N; Wainscoat, R; Waters, C

    2015-03-06

    Hypervelocity stars (HVSs) travel with velocities so high that they exceed the escape velocity of the Galaxy. Several acceleration mechanisms have been discussed. Only one HVS (US 708, HVS 2) is a compact helium star. Here we present a spectroscopic and kinematic analysis of US 708. Traveling with a velocity of ~1200 kilometers per second, it is the fastest unbound star in our Galaxy. In reconstructing its trajectory, the Galactic center becomes very unlikely as an origin, which is hardly consistent with the most favored ejection mechanism for the other HVSs. Furthermore, we detected that US 708 is a fast rotator. According to our binary evolution model, it was spun-up by tidal interaction in a close binary and is likely to be the ejected donor remnant of a thermonuclear supernova.

  9. Plasma physics effects on thermonuclear burn rate in the presence of hydrodynamic mix

    NASA Astrophysics Data System (ADS)

    Tang, Xian-Zhu; Guo, Zehua; Kagan, Grigory; McDevitt, Christopher; Srinivasan, Bhuvana

    2016-03-01

    Hydrodynamic mix can significantly degrade thermonuclear burn rate in an inertial confinement fusion (ICF) target. Successful mitigation requires a detailed understanding of the physical mechanisms by which mix affects burn. Here we summarize the roles of three distinct plasma physics effects on burn rate. The first is the well-known effect of enhanced thermal energy loss from the hot spot and the mitigating role of self-generated or externally-applied magnetic field. The second is the fuel ion separation via inter-species ion diffusion driven by the powerful thermodynamic forces exacerbated by mix during the implosion process. The third is the fusion reactivity modification by fast ion transport in a mix-dominated ICF target, where hot plasma is intermingled with cold fuel.

  10. Simulations of alpha particle ripple loss from the International Thermonuclear Experimental Reactor

    SciTech Connect

    Redi, M.H.; Budny, R.V.; McCune, D.C.; Miller, C.O.; White, R.B.

    1996-05-01

    Calculations of collisional stochastic ripple loss of alpha particles from the new 20 toroidal field (TF) coil International Thermonuclear Experimental Reactor (ITER) predict small alpha ripple losses, less than 0.4%, close to the loss calculated for the full current operation of the earlier 24 TF coil design. An analytic fit is obtained to the ITER ripple data field demonstrating the nonlinear height dependence of the ripple minimum for D shaped ripple contours. In contrast to alpha loss simulations for the Tokamak Fusion Test Reactor (TFTR), a simple Goldston, White, Boozer stochastic loss criterion ripple loss model is found to require an increased renormalization of the stochastic threshold {delta}{sub s}/{delta}{sub GWB} {ge} 1. Effects of collisions, sawtooth broadening and reversal of the grad B drift direction are included in the particle following simulations.

  11. Restless Legs

    MedlinePlus

    ... make symptoms worse. Lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. If those don't work, medicines may reduce the symptoms of RLS. Most people with ... usually during sleep. PLMD and RLS can also affect the arms. ...

  12. RELATIVISTIC COLLAPSE AND EXPLOSION OF ROTATING SUPERMASSIVE STARS WITH THERMONUCLEAR EFFECTS

    SciTech Connect

    Montero, Pedro J.; Janka, Hans-Thomas; Mueller, Ewald

    2012-04-10

    We present results of general relativistic simulations of collapsing supermassive stars with and without rotation using the two-dimensional general relativistic numerical code Nada, which solves the Einstein equations written in the BSSN formalism and the general relativistic hydrodynamic equations with high-resolution shock-capturing schemes. These numerical simulations use an equation of state that includes the effects of gas pressure and, in a tabulated form, those associated with radiation and the electron-positron pairs. We also take into account the effect of thermonuclear energy released by hydrogen and helium burning. We find that objects with a mass of Almost-Equal-To 5 Multiplication-Sign 10{sup 5} M{sub Sun} and an initial metallicity greater than Z{sub CNO} Almost-Equal-To 0.007 do explode if non-rotating, while the threshold metallicity for an explosion is reduced to Z{sub CNO} Almost-Equal-To 0.001 for objects uniformly rotating. The critical initial metallicity for a thermonuclear explosion increases for stars with a mass Almost-Equal-To 10{sup 6} M{sub Sun }. For those stars that do not explode, we follow the evolution beyond the phase of black hole (BH) formation. We compute the neutrino energy loss rates due to several processes that may be relevant during the gravitational collapse of these objects. The peak luminosities of neutrinos and antineutrinos of all flavors for models collapsing to a BH are L{sub {nu}} {approx} 10{sup 55} erg s{sup -1}. The total radiated energy in neutrinos varies between E{sub {nu}} {approx} 10{sup 56} erg for models collapsing to a BH and E{sub {nu}} {approx} 10{sup 45}-10{sup 46} erg for models exploding.

  13. A burst from a thermonuclear runaway on an ONeMg white dwarf

    NASA Technical Reports Server (NTRS)

    Starrfield, S.; Politano, M.; Truran, J. W.; Sparks, W. M.

    1992-01-01

    Studies which examine the consequences of accretion, at rates of 10(exp -9) solar mass/yr and 10(exp -10) solar mass/yr, onto an ONeMg white dwarf with a mass of 1.35 solar masses are performed. In these studies, a Lagrangian, hydrodynamic, one-dimensional computer code was used. The code now includes a network with 89 nuclei up to Ca-40, elemental diffusion, new opacities, and new equation of state. The initial abundance distribution corresponded to a mixture that was enriched to either 25, 50, or 75 percent in products of carbon burning. The remaining material in each case is assumed to have a solar composition. The evolution of the thermonuclear runaway in the 1.35 solar mass white dwarf, with M = 10(exp -9) solar mass, produced peak temperatures in the shell source exceeding 300 million degrees. The sequence produced significant amounts of Na-22 from proton captures onto Ne-20 and significant amounts of Al-26 from proton captures on Mg-24. This sequence ejected 5.2 x 10(exp -6) solar mass moving with speeds from approximately 100 km/s to 2300 km/s. When the mass accretion rate was decreased to 10(exp -10) solar mass, the resulting thermonuclear runaway produced a shock that moved through the outer envelope of the white dwarf and raised the surface luminosity to L greater than 10(exp 7) solar luminosity and the effective temperature to values exceeding 10(exp 7) K. The interaction of the material expanding from off of the white dwarf with the accretion disk should produce a burst of gamma-rays.

  14. Relativistic Collapse and Explosion of Rotating Supermassive Stars with Thermonuclear Effects

    NASA Astrophysics Data System (ADS)

    Montero, Pedro J.; Janka, Hans-Thomas; Müller, Ewald

    2012-04-01

    We present results of general relativistic simulations of collapsing supermassive stars with and without rotation using the two-dimensional general relativistic numerical code Nada, which solves the Einstein equations written in the BSSN formalism and the general relativistic hydrodynamic equations with high-resolution shock-capturing schemes. These numerical simulations use an equation of state that includes the effects of gas pressure and, in a tabulated form, those associated with radiation and the electron-positron pairs. We also take into account the effect of thermonuclear energy released by hydrogen and helium burning. We find that objects with a mass of ≈5 × 105 M ⊙ and an initial metallicity greater than Z CNO ≈ 0.007 do explode if non-rotating, while the threshold metallicity for an explosion is reduced to Z CNO ≈ 0.001 for objects uniformly rotating. The critical initial metallicity for a thermonuclear explosion increases for stars with a mass ≈106 M ⊙. For those stars that do not explode, we follow the evolution beyond the phase of black hole (BH) formation. We compute the neutrino energy loss rates due to several processes that may be relevant during the gravitational collapse of these objects. The peak luminosities of neutrinos and antineutrinos of all flavors for models collapsing to a BH are L ν ~ 1055 erg s-1. The total radiated energy in neutrinos varies between E ν ~ 1056 erg for models collapsing to a BH and E ν ~ 1045-1046 erg for models exploding.

  15. Use of liquid metals in nuclear and thermonuclear engineering, and in other innovative technologies

    NASA Astrophysics Data System (ADS)

    Rachkov, V. I.; Arnol'dov, M. N.; Efanov, A. D.; Kalyakin, S. G.; Kozlov, F. A.; Loginov, N. I.; Orlov, Yu. I.; Sorokin, A. P.

    2014-05-01

    By now, a good deal of experience has been gained with using liquid metals as coolants in nuclear power installations; extensive knowledge has been gained about the physical, thermophysical, and physicochemical properties of these coolants; and the scientific principles and a set of methods and means for handling liquid metals as coolants for nuclear power installations have been elaborated. Prototype and commercialgrade sodium-cooled NPP power units have been developed, including the BOR-60, BN-350, and BN-600 power units (the Soviet Union); the Rapsodie, Phenix, and Superphenix power units (France), the EBR-II power unit (the United States); and the PFR power unit (the United Kingdom). In Russia, dedicated nuclear power installations have been constructed, including those with a lead-bismuth coolant for nuclear submarines and with sodium-potassium alloy for spacecraft (the Buk and Topol installations), which have no analogs around the world. Liquid metals (primarily lithium and its alloy with lead) hold promise for use in thermonuclear power engineering, where they can serve not only as a coolant, but also as tritium-producing medium. In this article, the physicochemical properties of liquid metal coolants, as well as practical experience gained from using them in nuclear and thermonuclear power engineering and in innovative technologies are considered, and the lines of further research works are formulated. New results obtained from investigations carried out on the Pb-Bi and Pb for the SVBR and BREST fast-neutron reactors (referred to henceforth as fast reactors) and for controlled accelerator systems are described.

  16. A burst from a thermonuclear runaway on an ONeMg white dwarf

    NASA Astrophysics Data System (ADS)

    Starrfield, S.; Politano, M.; Truran, J. W.; Sparks, W. M.

    1992-02-01

    Studies which examine the consequences of accretion, at rates of 10-9 solar mass/yr and 10-10 solar mass/yr, onto an ONeMg white dwarf with a mass of 1.35 solar masses are performed. In these studies, a Lagrangian, hydrodynamic, one-dimensional computer code was used. The code now includes a network with 89 nuclei up to Ca-40, elemental diffusion, new opacities, and new equation of state. The initial abundance distribution corresponded to a mixture that was enriched to either 25, 50, or 75 percent in products of carbon burning. The remaining material in each case is assumed to have a solar composition. The evolution of the thermonuclear runaway in the 1.35 solar mass white dwarf, with M = 10-9 solar mass, produced peak temperatures in the shell source exceeding 300 million degrees. The sequence produced significant amounts of Na-22 from proton captures onto Ne-20 and significant amounts of Al-26 from proton captures on Mg-24. This sequence ejected 5.2 x 10-6 solar mass moving with speeds from approximately 100 km/s to 2300 km/s. When the mass accretion rate was decreased to 10-10 solar mass, the resulting thermonuclear runaway produced a shock that moved through the outer envelope of the white dwarf and raised the surface luminosity to L greater than 107 solar luminosity and the effective temperature to values exceeding 107 K. The interaction of the material expanding from off of the white dwarf with the accretion disk should produce a burst of gamma-rays.

  17. Restless leg syndrome in hospitalized psychiatric patients in Lebanon: a pilot study

    PubMed Central

    Talih, Farid; Ajaltouni, Jean; Kobeissy, Firas

    2016-01-01

    Objectives To characterize and describe the prevalence of restless leg syndrome (RLS) in hospitalized psychiatric patients and to investigate the correlations between patient profile and RLS. Methods Demographic information, psychiatric diagnoses, psychotropic medication use, and history of substance use were collected from hospitalized psychiatric patients at the American University of Beirut Medical Center; Beirut, Lebanon. A validated questionnaire to evaluate RLS symptomatology was also administered to 126 participants who agreed to participate, as well as questionnaires for insomnia, depression, and anxiety symptoms. Statistical analysis was conducted to detect the prevalence of RLS among the participants and to examine correlations with RLS in a hospitalized psychiatric population. Results Out of the 126 participants who completed the survey, RLS was detected in 18% of the participants. Of interest, RLS was also found to be associated with higher depressive symptomatology, suicidal ideation, and working night shifts. PMID:27785035

  18. Behavioral Sleep Medicine Interventions for Restless Legs Syndrome and Periodic Limb Movement Disorder

    PubMed Central

    Pigeon, Wilfred R.; Yurcheshen, Michael

    2009-01-01

    SYNOPSIS Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder (PLMD) are sleep disorders that are commonly seen in clinical practice. The standard treatment recommendations for these disorders are pharmacologic; most recently both conditions are most typically managed with pramipexole or ropinerole, which are FDA approved for the treatment of RLS. A mix of behavioral suggestions is included in treatment algorithms for providers as well as in patient education materials. While these suggestions have considerable merit, they are typically not delivered as an intervention, but instead provided as a series of helpful tips. There is emerging evidence for providing such suggestions as a more active and comprehensive intervention as part of a cognitive-behavioral package as well as for exercise therapy and cognitive behavioral therapy for insomnia to be delivered as active treatments for RLS and/or PLMD. PMID:20161553

  19. The Restless Universe - Understanding X-Ray Astronomy in the Age of Chandra and Newton

    NASA Astrophysics Data System (ADS)

    Schlegel, Eric M.

    2002-10-01

    Carl Sagan once noted that there is only one generation that gets to see things for the first time. We are in the midst of such a time right now, standing on the threshold of discovery in the young and remarkable field of X-ray astronomy. In The Restless Universe , astronomer Eric Schlegel offers readers an informative survey of this cutting-edge science. Two major space observatories launched in the last few years--NASA's Chandra and the European Newton --are now orbiting the Earth, sending back a gold mine of data on the X-ray universe. Schlegel, who has worked on the Chandra project for seven years, describes the building and launching of this space-based X-ray observatory. But the book goes far beyond the story of Chandra . What Schlegel provides here is the background a nonscientist would need to grasp the present and follow the future of X-ray astronomy. He looks at the relatively brief history of the field, the hardware used to detect X-rays, the satellites--past, present, and future--that have been or will be flown to collect the data, the way astronomers interpret this data, and, perhaps most important, the insights we have already learned as well as speculations about what we may soon discover. And throughout the book, Schlegel conveys the excitement of looking at the universe from the perspective brought by these new observatories and the sharper view they deliver. Drawing on observations obtained from Chandra, Newton , and previous X-ray observatories, The Restless Universe gives a first look at an exciting field which significantly enriches our understanding of the universe.

  20. A separate circadian oscillator controls nocturnal migratory restlessness in the songbird Sylvia borin.

    PubMed

    Bartell, Paul A; Gwinner, Eberhard

    2005-12-01

    When confined to a cage, migratory songbirds exhibit nocturnal migratory restlessness (also called Zugunruhe) during the spring and autumn migratory periods, even though these birds are exclusively diurnal during the remainder of the year. Zugunruhe, which has been demonstrated to be under the direct control of a circannual timer, is characterized by a stereotypic "wing-whirring" behavior while the bird is perched. To elucidate the role played by the circadian system in the regulation of Zugunruhe, the authors studied the activity of garden warblers (Sylvia borin), long-distance nocturnal migrants, under skeleton photoperiods of different lengths and under constant dim light. In 11.5D:1L:10.5D:1L skeleton photoperiods, the authors found that Zugunruhe free-ran in a substantial proportion of birds, while their normal daily activities (e.g., feeding and preening) remained synchronized to 24 h. Some birds expressing Zugunruhe under constant dim light continued to show 2 distinct bouts of activity: one corresponding to daily activities, the other to wing-whirring. In some cases, these 2 bouts crossed while free-running with different periods. Birds expressing Zugunruhe also had significantly longer free-running periods than birds that did not. The study data suggest that the seasonal appearance of Zugunruhe is the result of the interactions of at least 2 circadian oscillators and that it is the phase relationship of these 2 oscillators that determines when nocturnal migratory restlessness is expressed. Furthermore, these data are consistent with the previously proposed internal coincidence hypothesis as a model for the ontogeny of circannual rhythms.

  1. INDEXABILITY AND OPTIMAL INDEX POLICIES FOR A CLASS OF REINITIALISING RESTLESS BANDITS

    PubMed Central

    Villar, Sofía S.

    2016-01-01

    Motivated by a class of Partially Observable Markov Decision Processes with application in surveillance systems in which a set of imperfectly observed state processes is to be inferred from a subset of available observations through a Bayesian approach, we formulate and analyze a special family of multi-armed restless bandit problems. We consider the problem of finding an optimal policy for observing the processes that maximizes the total expected net rewards over an infinite time horizon subject to the resource availability. From the Lagrangian relaxation of the original problem, an index policy can be derived, as long as the existence of the Whittle index is ensured. We demonstrate that such a class of reinitializing bandits in which the projects’ state deteriorates while active and resets to its initial state when passive until its completion possesses the structural property of indexability and we further show how to compute the index in closed form. In general, the Whittle index rule for restless bandit problems does not achieve optimality. However, we show that the proposed Whittle index rule is optimal for the problem under study in the case of stochastically heterogenous arms under the expected total criterion, and it is further recovered by a simple tractable rule referred to as the 1-limited Round Robin rule. Moreover, we illustrate the significant suboptimality of other widely used heuristic: the Myopic index rule, by computing in closed form its suboptimality gap. We present numerical studies which illustrate for the more general instances the performance advantages of the Whittle index rule over other simple heuristics. PMID:27212781

  2. Restless Legs Syndrome, Sleep, and Quality of Life among Adolescents and Young Adults

    PubMed Central

    Silva, Graciela E.; Goodwin, James L.; Vana, Kimberly D.; Vasquez, Monica M.; Wilcox, Peter G.; Quan, Stuart F.

    2014-01-01

    Objective: Clinical reports in children implicate restless legs syndrome (RLS) with sleep and behavior problems. However, population-based studies on this association in adolescents and young adults are limited. Furthermore, few studies have evaluated the association between symptoms consistent with RLS and quality of life (QoL). Study Design: This cross-sectional study included 214 Caucasian and Hispanic adolescents and young adults aged 12-20 years. Symptoms consistent with RLS were based on four essential criteria and if the symptoms occurred ≥ 5 days/ month. Trouble falling asleep was present if reported “yes, still have the problem.” Quality of life (QoL) was assessed using the Pediatric QoL Inventory. Three summary QoL scores ranging from 0-100 were evaluated; higher scores indicated better QoL. Results: Participants were 50% male and 68.1% Caucasian. Prevalence of RLS was 8.4% (n = 18). RLS was associated with trouble falling asleep (OR = 3.1, p = 0.049), and trouble falling asleep was associated with worse Psychosocial Health scores (Coeff. −5.6, p = 0.004) and Total Scale scores for quality of life (Coeff. −4.6, p = 0.007). Conclusions: The prevalence of symptoms consistent with RLS in this community-based sample of adolescents and young adults, aged 12-20, is comparable to rates reported in older cohorts. Symptoms consistent with RLS may be associated with trouble falling asleep and psychosocial distress that may contribute to a lower health-related quality of life. Citation: Silva GE, Goodwin JL, Vana KD, Vasquez MM, Wilcox PG, Quan SF. Restless legs syndrome, sleep, and quality of life among adolescents and young adults. J Clin Sleep Med 2014;10(7):779-786. PMID:25024656

  3. Restless Leg Syndrome in Different Types of Demyelinating Neuropathies: A Single-Center Pilot Study

    PubMed Central

    Luigetti, Marco; Del Grande, Alessandra; Testani, Elisa; Bisogni, Giulia; Losurdo, Anna; Giannantoni, Nadia Mariagrazia; Mazza, Salvatore; Sabatelli, Mario; Della Marca, Giacomo

    2013-01-01

    Objective: to determine the prevalence of restless legs syndrome (RLS) in a cohort of patients with demyelinating neuropathies. Methods: Patients were retrospectively recruited from our cohort of different forms of demyelinating neuropathies, including chronic inflammatory demyelinating neuropathy (CIDP), Charcot-Marie-Tooth 1A (CMT1A), and hereditary neuropathy with liability to pressure palsies (HNPP) referred to our Department of Neurology in a 10-year period. The validated 4-item RLS questionnaire was used for diagnosis of RLS. All patients with RLS who fulfilled criteria underwent a suggested immobilization test to confirm the diagnosis. A group of outpatients referred to the sleep disorders unit and data from published literature were used as controls. Results: Prevalence of RLS in demyelinating neuropathy group was higher than prevalence observed in control population (p = 0.0142) or in the literature data (p = 0.0007). In particular, in comparison with both control population and literature data, prevalence of RLS was higher in CIDP group (p = 0.0266 and p = 0.0063, respectively) and in CMT1A group (p = 0.0312 and p = 0.0105, respectively), but not in HNPP (p = 1.000 and p = 0.9320, respectively). Conclusions: our study confirms a high prevalence of RLS in inflammatory neuropathies as CIDP and, among inherited neuropathies, in CMT1A but not in HNPP. Considering that this is only a small cohort from a single-center retrospective experience, the link between RLS and neuropathy remains uncertain, and larger multicenter studies are probably needed to clarify the real meaning of the association between RLS and neuropathy. Citation: Luigetti M; Del Grande A; Testani E; Bisogni G; Losurdo A; Giannantoni NM; Mazza S; Sabatelli M; Della Marca G. Restless leg syndrome in different types of demyelinating neuropathies: a single-center pilot study. J Clin Sleep Med 2013;9(9):945-949. PMID:23997707

  4. Magnitude-Dependent Seismic Quiescence: A Meta-Analysis of Data and Numerical Simulations of the Underlying Physics

    NASA Astrophysics Data System (ADS)

    Smith, D. E.; Sacks, S. I.

    2013-12-01

    Magnitude-dependent seismic quiescence, the slowing down or ceasing of background seismicity above a threshold magnitude prior to a major earthquake, has been observed for many earthquakes including the 1982 Urakawa-Oki [Taylor et al., 1991] and the 1994 Hokkaido-Toho-Oki [Takanami et al., 1996] in Japan, and the 1994 Northridge earthquake in California [Smith and Sacks, 2013 submitted]. Magnitude-dependent quiescence is a more robust observation than simple quiescence, because the cessation of seismicity in certain magnitude bins but not others, allows one to rule out overall fluctuations in seismicity rate as a source of the signal. We postulate that the mechanism behind magnitude-dependent quiescence involves dilatant expansion of stress asperities in the medium. Under high stress, rock will dilate or volumetrically expand, which will lower the pore pressure and increase the effective normal stress in a water-saturated medium. These higher stress asperities, which tend to release a large stress drop and shear strain energy into the medium when they fail, now become locked due to the increased normal stress. Based on the model of Rydelek and Sacks [1995], which modeled the fault surface as a set of interacting small segments (roughly equivalent in size to the inner-scale of fault roughness), we have seen that events above a threshold magnitude require the failure of a number segments; hence, the clamping of high stress asperities should have the effect of quieting down and ceasing events above a threshold magnitude, since it is the failure of high stress asperities that is most likely to propagate rupture to other segments. We investigate this hypothesized model via: 1) A meta-analysis of data and 2) a numerical model. In the meta-analysis, we examine regions of high deviatoric stress to see how well their behavior agrees with the postulate. Indeed, virtually every observation of quiescence occurs in a compressional environment with a relatively high shear stress

  5. A Remarkable Three Hour Thermonuclear Burst from 4U 1820-30

    NASA Technical Reports Server (NTRS)

    Strohmayer, Tod E.; Brown, Edward F.; White, Nicholas E. (Technical Monitor)

    2002-01-01

    We present a detailed observational and theoretical study of an approximately three hour long X-ray burst (the "super burst") observed by the Rossi X-ray Timing Explorer (RXTE) from the low mass X-ray binary (LMXB) 4U 1820-30. This is the longest X-ray burst ever observed from this source, and perhaps one of the longest ever observed in great detail from any source. We show that the super burst is thermonuclear in origin. Its peak luminosity of approximately 3.4 x 10(exp 38) ergs s(exp -1) is consistent with the helium Eddington limit for a neutron star at approximately 7 kpc, as well as the peak luminosity of other, shorter, thermonuclear bursts from the same source. The super burst begins in the decaying tail of a more typical (approximately equal to 20 s duration) thermonuclear burst. These shorter, more frequent bursts are well known helium flashes from this source. The level of the accretion driven flux as well as the observed energy release of upwards of 1.5 x 10(exp 42) ergs indicate that helium could not be the energy source for the super burst. We outline the physics relevant to carbon production and burning on helium accreting neutron stars and present calculations of the thermal evolution and stability of a carbon layer and show that this process is the most likely explanation for the super burst. Ignition at the temperatures in the deep carbon "ocean" requires greater than 30 times the mass of carbon inferred from the observed burst energetics unless the He flash is able to trigger a deflagration from a much smaller mass of carbon. We show, however, that for large columns of accreted carbon fuel, a substantial fraction of the energy released in the carbon burning layer is radiated away as neutrinos, and the heat that is conducted from the burning layer in large part flows inward, only to be released on timescales longer than the observed burst. Thus the energy released during the event possibly exceeds that observed in X-rays by more than a factor of

  6. Igniting the Light Elements: The Los Alamos Thermonuclear Weapon Project, 1942-1952

    SciTech Connect

    Fitzpatrick, Anne C.

    1999-07-01

    The American system of nuclear weapons research and development was conceived and developed not as a result of technological determinism, but by a number of individual architects who promoted the growth of this large technologically-based complex. While some of the technological artifacts of this system, such as the fission weapons used in World War II, have been the subject of many historical studies, their technical successors--fusion (or hydrogen) devices--are representative of the largely unstudied highly secret realms of nuclear weapons science and engineering. In the postwar period a small number of Los Alamos Scientific Laboratory's staff and affiliates were responsible for theoretical work on fusion weapons, yet the program was subject to both the provisions and constraints of the US Atomic Energy Commission, of which Los Alamos was a part. The Commission leadership's struggle to establish a mission for its network of laboratories, least of all to keep them operating, affected Los Alamos's leaders' decisions as to the course of weapons design and development projects. Adapting Thomas P. Hughes's ''large technological systems'' thesis, I focus on the technical, social, political, and human problems that nuclear weapons scientists faced while pursuing the thermonuclear project, demonstrating why the early American thermonuclear bomb project was an immensely complicated scientific and technological undertaking. I concentrate mainly on Los Alamos Scientific Laboratory's Theoretical, or T, Division, and its members' attempts to complete an accurate mathematical treatment of the ''Super''--the most difficult problem in physics in the postwar period--and other fusion weapon theories. Although tackling a theoretical problem, theoreticians had to address technical and engineering issues as well. I demonstrate the relative value and importance of H-bomb research over time in the postwar era to scientific, politician, and military participants in this project. I

  7. Msa1 and Msa2 Modulate G1-Specific Transcription to Promote G1 Arrest and the Transition to Quiescence in Budding Yeast

    PubMed Central

    Miles, Shawna; Croxford, Matthew W.; Abeysinghe, Amali P.; Breeden, Linda L.

    2016-01-01

    Yeast that naturally exhaust their glucose source can enter a quiescent state that is characterized by reduced cell size, and high cell density, stress tolerance and longevity. The transition to quiescence involves highly asymmetric cell divisions, dramatic reprogramming of transcription and global changes in chromatin structure and chromosome topology. Cells enter quiescence from G1 and we find that there is a positive correlation between the length of G1 and the yield of quiescent cells. The Swi4 and Swi6 transcription factors, which form the SBF transcription complex and promote the G1 to S transition in cycling cells, are also critical for the transition to quiescence. Swi6 forms a second complex with Mbp1 (MBF), which is not required for quiescence. These are the functional analogues of the E2F complexes of higher eukaryotes. Loss of the RB analogue, Whi5, and the related protein Srl3/Whi7, delays G1 arrest, but it also delays recovery from quiescence. Two MBF- and SBF-Associated proteins have been identified that have little effect on SBF or MBF activity in cycling cells. We show that these two related proteins, Msa1 and Msa2, are specifically required for the transition to quiescence. Like the E2F complexes that are quiescence-specific, Msa1 and Msa2 are required to repress the transcription of many SBF target genes, including SWI4, the CLN2 cyclin and histones, specifically after glucose is exhausted from the media. They also activate transcription of many MBF target genes. msa1msa2 cells fail to G1 arrest and rapidly lose viability upon glucose exhaustion. msa1msa2 mutants that survive this transition are very large, but they attain the same thermo-tolerance and longevity of wild type quiescent cells. This indicates that Msa1 and Msa2 are required for successful transition to quiescence, but not for the maintenance of that state. PMID:27272642

  8. Influence of the tritium beta(-) decay on low-temperature thermonuclear burn-up in deuterium-tritium mixtures

    PubMed

    Frolov

    2000-09-01

    Low-temperature (Tthermonuclear burn-up in deuterium-tritium mixtures with various deuterium-tritium-helium-3 ratios is considered. The general dependence is studied for the critical burn-up parameter x(c)=rhor(c) upon the initial temperature T, density rho(0), and tritium molar concentration y for the [D]:y[T]:(1-y)[3He] mixture. In particular, it is shown that, if the tritium concentration y decreases, then the critical burn-up parameter x(c)(T,rho(0),y) grows very quickly (at fixed T and rho(0)). This means that tritium beta(-) decay significantly complicates thermonuclear burn-up in deuterium-tritium mixtures.

  9. A new algorithm for the detection of seismic quiescence: introduction of the RTM algorithm, a modified RTL algorithm

    NASA Astrophysics Data System (ADS)

    Nagao, Toshiyasu; Takeuchi, Akihiro; Nakamura, Kenji

    2011-03-01

    There are a number of reports on seismic quiescence phenomena before large earthquakes. The RTL algorithm is a weighted coefficient statistical method that takes into account the magnitude, occurrence time, and place of earthquake when seismicity pattern changes before large earthquakes are being investigated. However, we consider the original RTL algorithm to be overweighted on distance. In this paper, we introduce a modified RTL algorithm, called the RTM algorithm, and apply it to three large earthquakes in Japan, namely, the Hyogo-ken Nanbu earthquake in 1995 ( M JMA7.3), the Noto Hanto earthquake in 2007 ( M JMA 6.9), and the Iwate-Miyagi Nairiku earthquake in 2008 ( M JMA 7.2), as test cases. Because this algorithm uses several parameters to characterize the weighted coefficients, multiparameter sets have to be prepared for the tests. The results show that the RTM algorithm is more sensitive than the RTL algorithm to seismic quiescence phenomena. This paper represents the first step in a series of future analyses of seismic quiescence phenomena using the RTM algorithm. At this moment, whole surveyed parameters are empirically selected for use in the method. We have to consider the physical meaning of the "best fit" parameter, such as the relation of ACFS, among others, in future analyses.

  10. Detection of Cardiac Quiescence from B-Mode Echocardiography Using a Correlation-Based Frame-to-Frame Deviation Measure

    PubMed Central

    Mcclellan, James H.; Ravichandran, Lakshminarayan; Tridandapani, Srini

    2013-01-01

    Two novel methods for detecting cardiac quiescent phases from B-mode echocardiography using a correlation-based frame-to-frame deviation measure were developed. Accurate knowledge of cardiac quiescence is crucial to the performance of many imaging modalities, including computed tomography coronary angiography (CTCA). Synchronous electrocardiography (ECG) and echocardiography data were obtained from 10 healthy human subjects (four male, six female, 23–45 years) and the interventricular septum (IVS) was observed using the apical four-chamber echocardiographic view. The velocity of the IVS was derived from active contour tracking and verified using tissue Doppler imaging echocardiography methods. In turn, the frame-to-frame deviation methods for identifying quiescence of the IVS were verified using active contour tracking. The timing of the diastolic quiescent phase was found to exhibit both inter- and intra-subject variability, suggesting that the current method of CTCA gating based on the ECG is suboptimal and that gating based on signals derived from cardiac motion are likely more accurate in predicting quiescence for cardiac imaging. Two robust and efficient methods for identifying cardiac quiescent phases from B-mode echocardiographic data were developed and verified. The methods presented in this paper will be used to develop new CTCA gating techniques and quantify the resulting potential improvement in CTCA image quality. PMID:26609501

  11. Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations.

    PubMed

    Limousin, Nadège; Konofal, Eric; Karroum, Elias; Lohmann, Ebba; Theodorou, Ioannis; Dürr, Alexandra; Arnulf, Isabelle

    2009-10-15

    Parkin gene mutations cause a juvenile parkinsonism. Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep-wake phenotype in patients with two parkin mutations, compared with patients with idiopathic Parkinson's disease (iPD). Sleep interview and overnight video-polysomnography, followed by multiple sleep latency tests, were assessed in 11 consecutive patients with two parkin mutations (aged 35-60 years, from seven families) and 11 sex-matched patients with iPD (aged 51-65 years). Sleep complaints in the parkin group included insomnia (73% patients versus 45% in the iPD group), restless legs syndrome (45%, versus none in the iPD group, P = 0.04), and daytime sleepiness (45%, versus 54% in the iPD group). Of the parkin patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the parkin and iPD groups. Two parkin siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two parkin mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported in iPD, except that restless legs syndrome was more prevalent and secondary narcolepsy was absent.

  12. INTERACTION OF LASER RADIATION WITH MATTER. LASER PLASMA: Model of mixing of shells of a thermonuclear laser target upon spherical compression

    NASA Astrophysics Data System (ADS)

    Zmitrenko, N. V.; Proncheva, N. G.; Rozanov, Vladislav B.; Yakhin, R. A.

    2007-08-01

    Based on many direct numerical simulations of the development of hydrodynamic instabilities upon compression of laser thermonuclear targets, an efficient model is developed for describing the width of the mixing region taking into account the influence of the initial conditions on the mixing process dynamics. Approaches are proposed which are based on the evolution theory of the development of hydrodynamic instabilities [1], which was specially elaborated to describe the compression of targets for inertial thermonuclear fusion.

  13. Suzaku Observation of the Classical Nova V2491 Cyg in Quiescence

    NASA Technical Reports Server (NTRS)

    Zemko, P.; Mukai, K.; Orio, M.

    2015-01-01

    We present Suzaku XIS observation of V2491 Cyg (Nova Cyg 2008 No. 2) obtained in quiescence, more than two years after the outburst. The nova was detected as a very luminous source in a wide spectral range from soft to hard X-rays. A very soft blackbody-like component peaking at 0.5 keV indicates that either we observe remaining, localized hydrogen burning on the surface of the white dwarf, or accretion onto a magnetized polar cap. In the second case, V2491 Cyg is a candidate "soft intermediate polar". We obtained the best fit for the X-ray spectra with several components: two of thermal plasma, a blackbody and a complex absorber. The later is typical of intermediate polars. The X-ray light-curve shows a modulation with an approximately 38 min period. The amplitude of this modulation is strongly energy dependent and reaches maximum in the 0.8-2.0 keV range. We discuss the origin of the X-ray emission and pulsations, and the likelihood of the intermediate polar scenario.

  14. Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.

    PubMed

    Liu, Ling; Cheung, Tom H; Charville, Gregory W; Hurgo, Bernadette Marie Ceniza; Leavitt, Tripp; Shih, Johnathan; Brunet, Anne; Rando, Thomas A

    2013-07-11

    The ability to maintain quiescence is critical for the long-term maintenance of a functional stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem cells and how they change with age remain largely unknown. In this study, we explore the chromatin features of adult skeletal muscle stem cells, or satellite cells (SCs), which reside predominantly in a quiescent state in fully developed limb muscles of both young and aged mice. Using a ChIP-seq approach to obtain global epigenetic profiles of quiescent SCs (QSCs), we show that QSCs possess a permissive chromatin state in which few genes are epigenetically repressed by Polycomb group (PcG)-mediated histone 3 lysine 27 trimethylation (H3K27me3), and a large number of genes encoding regulators that specify nonmyogenic lineages are demarcated by bivalent domains at their transcription start sites (TSSs). By comparing epigenetic profiles of QSCs from young and old mice, we also provide direct evidence that, with age, epigenetic changes accumulate and may lead to a functional decline in quiescent stem cells. These findings highlight the importance of chromatin mapping in understanding unique features of stem cell identity and stem cell aging.

  15. CD44 Transmembrane Receptor and Hyaluronan Regulate Adult Hippocampal Neural Stem Cell Quiescence and Differentiation.

    PubMed

    Su, Weiping; Foster, Scott C; Xing, Rubing; Feistel, Kerstin; Olsen, Reid H J; Acevedo, Summer F; Raber, Jacob; Sherman, Larry S

    2017-03-17

    Adult neurogenesis in the hippocampal subgranular zone (SGZ) is involved in learning and memory throughout life but declines with aging. Mice lacking the CD44 transmembrane receptor for the glycosaminoglycan hyaluronan (HA) demonstrate a number of neurological disturbances including hippocampal memory deficits, implicating CD44 in the processes underlying hippocampal memory encoding, storage, or retrieval. Here, we found that HA and CD44 play important roles in regulating adult neurogenesis, and we provide evidence that HA contributes to age-related reductions in neural stem cell (NSC) expansion and differentiation in the hippocampus. CD44-expressing NSCs isolated from the mouse SGZ are self-renewing and capable of differentiating into neurons, astrocytes, and oligodendrocytes. Mice lacking CD44 demonstrate increases in NSC proliferation in the SGZ. This increased proliferation is also observed in NSCs grown in vitro, suggesting that CD44 functions to regulate NSC proliferation in a cell-autonomous manner. HA is synthesized by NSCs and increases in the SGZ with aging. Treating wild type but not CD44-null NSCs with HA inhibits NSC proliferation. HA digestion in wild type NSC cultures or in the SGZ induces increased NSC proliferation, and CD44-null as well as HA-disrupted wild type NSCs demonstrate delayed neuronal differentiation. HA therefore signals through CD44 to regulate NSC quiescence and differentiation, and HA accumulation in the SGZ may contribute to reductions in neurogenesis that are linked to age-related decline in spatial memory.

  16. SUZAKU OBSERVATION OF THE CLASSICAL NOVA V2491 Cyg IN QUIESCENCE

    SciTech Connect

    Zemko, P.; Mukai, K.; Orio, M. E-mail: koji.mukai@umbc.edu

    2015-07-01

    We present the Suzaku XIS observation of V2491 Cyg (Nova Cyg 2008 No. 2) obtained in quiescence, more than two years after the outburst. The nova was detected as a very luminous source in a wide spectral range from soft to hard X-rays. A very soft blackbody-like component peaking at 0.5 keV indicates that we observe either remaining, localized hydrogen burning on the surface of the white dwarf, or accretion onto a magnetized polar cap. In the second case, V2491 Cyg is a candidate “soft intermediate polar.” We obtained the best fit for the X-ray spectra with several components: two of thermal plasma, a blackbody and a complex absorber. The latter is typical of intermediate polars. The X-ray light curve shows a modulation with a period of ∼38 minutes. The amplitude of this modulation is strongly energy-dependent and reaches a maximum in the range 0.8–2.0 keV. We discuss the origin of the X-ray emission and pulsations, and the likelihood of the intermediate polar scenario.

  17. Keratin14 mRNA expression in human pneumocytes during quiescence, repair and disease

    PubMed Central

    Confalonieri, Marco; Buratti, Emanuele; Grassi, Gabriele; Bussani, Rossana; Chilosi, Marco; Farra, Rossella; Abrami, Michela; Stuani, Cristiana; Salton, Francesco; Ficial, Miriam; Confalonieri, Paola; Zandonà, Lorenzo; Romano, Maurizio

    2017-01-01

    The lung alveoli slowly self-renew pneumocytes, but their facultative regeneration capacity is rapidly efficient after an injury, so fibrosis infrequently occurs. We recently observed Keratin 14 (KRT14) expression during diffuse alveolar damage (DAD), but not in controls. We wonder if KRT14 may be a marker of pneumocyte transition from quiescence to regeneration. Quantitative PCR and Western blot analyses highlighted the presence of KRT14 (mRNA and protein) only in human lung samples with DAD or interstitial lung disease (ILD). In the exponentially growing cell lines A549 and H441, the mRNA and protein levels of KRT14 peaked at day one after cell seeding and decreased at day two, opposite to what observed for the proliferation marker E2F1. The inverse relation of KRT14 versus E2F1 expression holds true also for other proliferative markers, such as cyclin E1 and cyclin D1. Of interest, we also found that E2F1 silencing caused cell cycle arrest and increased KRT14 expression, whilst E2F1 stimulation induced cell cycle progression and decreased KRT14. KRT14 also increased in proliferative pneumocytes (HPAEpiC) just before transdifferentiation. Overall, our results suggest that KRT14 is a viable biomarker of pneumocyte activation, and repair/regeneration. The involvement of KRT14 in regenerative process may suggest a novel pharmaceutical target to accelerate lung repair. PMID:28199407

  18. Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

    PubMed Central

    Chen, Wanyin; Dong, Jihu; Haiech, Jacques; Kilhoffer, Marie-Claude

    2016-01-01

    Cells with stem-like properties, tumorigenic potential, and treatment-resistant phenotypes have been identified in many human malignancies. Based on the properties they share with nonneoplastic stem cells or their ability to initiate and propagate tumors in vivo, such cells were designated as cancer stem (stem-like) or tumor initiating/propagating cells. Owing to their implication in treatment resistance, cancer stem cells (CSCs) have been the subject of intense investigation in past years. Comprehension of CSCs' intrinsic properties and mechanisms they develop to survive and even enhance their aggressive phenotype within the hostile conditions of the tumor microenvironment has reoriented therapeutic strategies to fight cancer. This report provides selected examples of malignancies in which the presence of CSCs has been evidenced and briefly discusses methods to identify, isolate, and functionally characterize the CSC subpopulation of cancer cells. Relevant biological targets in CSCs, their link to treatment resistance, proposed targeting strategies, and limitations of these approaches are presented. Two major aspects of CSC physiopathology, namely, relative in vivo quiescence and plasticity in response to microenvironmental cues or treatment, are highlighted. Implications of these findings in the context of the development of new therapies are discussed. PMID:27418931

  19. LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence.

    PubMed

    Andrusiak, Matthew G; Vandenbosch, Renaud; Dick, Fred A; Park, David S; Slack, Ruth S

    2013-05-01

    Neuronal survival is dependent upon the retinoblastoma family members, Rb1 (Rb) and Rb2 (p130). Rb is thought to regulate gene repression, in part, through direct recruitment of chromatin modifying enzymes to its conserved LXCXE binding domain. We sought to examine the mechanisms that Rb employs to mediate cell cycle gene repression in terminally differentiated cortical neurons. Here, we report that Rb loss converts chromatin at the promoters of E2f-target genes to an activated state. We established a mouse model system in which Rb-LXCXE interactions could be induciblely disabled. Surprisingly, this had no effect on survival or gene silencing in neuronal quiescence. Absence of the Rb LXCXE-binding domain in neurons is compatible with gene repression and long-term survival, unlike Rb deficiency. Finally, we are able to show that chromatin activation following Rb deletion occurs at the level of E2fs. Blocking E2f-mediated transcription downstream of Rb loss is sufficient to maintain chromatin in an inactive state. Taken together our results suggest a model whereby Rb-E2f interactions are sufficient to maintain gene repression irrespective of LXCXE-dependent chromatin remodeling.

  20. Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence

    SciTech Connect

    Golding, Jon P. . E-mail: j.p.golding@open.ac.uk; Calderbank, Emma; Partridge, Terence A.; Beauchamp, Jonathan R.

    2007-01-15

    To be effective for tissue repair, satellite cells (the stem cells of adult muscle) must survive the initial activation from quiescence. Using an in vitro model of satellite cell activation, we show that erbB1, erbB2 and erbB3, members of the EGF receptor tyrosine kinase family, appear on satellite cells within 6 h of activation. We show that signalling via erbB2 provides an anti-apoptotic survival mechanism for satellite cells during the first 24 h, as they progress to a proliferative state. Inhibition of erbB2 signalling with AG825 reduced satellite cell numbers, concomitant with elevated caspase-8 activation and TUNEL labelling of apoptotic satellite cells. In serum-free conditions, satellite cell apoptosis could be largely prevented by a mixture of erbB1, erbB3 and erbB4 ligand growth factors, but not by neuregulin alone (erbB3/erbB4 ligand). Furthermore, using inhibitors specific to discrete intracellular signalling pathways, we identify MEK as a pro-apoptotic mediator, and the erbB-regulated factor STAT3 as an anti-apoptotic mediator during satellite cell activation. These results implicate erbB2 signalling in the preservation of a full compliment of satellite cells as they activate in the context of a damaged muscle.

  1. Regulation of Exit from Quiescence by p27 and Cyclin D1-CDK4

    PubMed Central

    Ladha, Mohamed H.; Lee, Kwang Y.; Upton, Todd M.; Reed, Michael F.; Ewen, Mark E.

    1998-01-01

    The synthesis of cyclin D1 and its assembly with cyclin-dependent kinase 4 (CDK4) to form an active complex is a rate-limiting step in progression through the G1 phase of the cell cycle. Using an activated allele of mitogen-activated protein kinase kinase 1 (MEK1), we show that this kinase plays a significant role in positively regulating the expression of cyclin D1. This was found both in quiescent serum-starved cells and in cells expressing dominant-negative Ras. Despite the observation that cyclin D1 is a target of MEK1, in cycling cells, activated MEK1, but not cyclin D1, is capable of overcoming a G1 arrest induced by Ras inactivation. Either wild-type or catalytically inactive CDK4 cooperates with cyclin D1 in reversing the G1 arrest induced by inhibition of Ras activity. In quiescent NIH 3T3 cells expressing either ectopic cyclin D1 or activated MEK1, cyclin D1 is able to efficiently associate with CDK4; however, the complex is inactive. A significant percentage of the cyclin D1-CDK4 complexes are associated with p27 in serum-starved activated MEK1 or cyclin D1 cell lines. Reduction of p27 levels by expression of antisense p27 allows for S-phase entry from quiescence in NIH 3T3 cells expressing ectopic cyclin D1, but not in parental cells. PMID:9774675

  2. Stationary phase lipophagy as a cellular mechanism to recycle sterols during quiescence.

    PubMed

    Wang, Chao-Wen

    2014-01-01

    Delivery of cellular contents to yeast vacuoles/mammalian lysosomes via autophagy ensures long-term cell survival and extends life span. When cultured yeast cells are grown for a prolonged period of time to enter stationary phase, a nondividing state mimicking quiescence, vacuolar membrane proteins partition into either one of the vacuolar microdomains, liquid-ordered (Lo) or liquid-disordered (Ld). We show that during the transition to stationary phase, lipid droplets (LDs), organelles originated from the endoplasmic reticulum (ER), undergo lateral movement to reach the vacuolar surface and are confined within the specific Lo microdomain underlying the network of vacuolar quasi-symmetrical micodomains. Stationary phase lipophagy uses the autophagy machineries to modify the sterol-enriched Lo microdomain to engulf LDs and subsequently deposits the LD-containing vesicles inside the vacuole lumen, which is a pathway morphologically resembling microautophagy. Moreover, stationary phase lipophagy supplies quiescent yeast cells with sterols to sustain phase partitioning of lipids for vacuolar microdomain maintenance. A feed forward loop model was proposed to depict that the sterols boosted by LDs via stationary phase lipophagy promote the Lo microdomain maintenance that in turn stimulates lipophagy.

  3. Quenching vs. Quiescence: forming realistic massive ellipticals with a simple starvation model

    NASA Astrophysics Data System (ADS)

    Gutcke, Thales A.; Macciò, Andrea V.; Dutton, Aaron A.; Stinson, Greg S.

    2017-01-01

    The decrease in star formation (SF) and the morphological change necessary to produce the z = 0 elliptical galaxy population are commonly ascribed to a sudden quenching event, which is able to rid the central galaxy of its cold gas reservoir in a short time. Following this event, the galaxy is able to prevent further SF and stay quiescent via a maintenance mode. We test whether such a quenching event is truly necessary using a simple model of quiescence. In this model, hot gas (all gas above a temperature threshold) in a ˜1012 M⊙ halo mass galaxy at redshift z ˜ 3 is prevented from cooling. The cool gas continues to form stars at a decreasing rate and the galaxy stellar mass, morphology, velocity dispersion and position on the color magnitude diagram (CMD) proceed to evolve. By z = 0, the halo mass has grown to 1013 M⊙ and the galaxy has attained characteristics typical of an observed z = 0 elliptical galaxy. Our model is run in the framework of a cosmological, smooth particle hydrodynamic code which includes SF, early stellar feedback, supernova feedback, metal cooling and metal diffusion. Additionally, we post-process our simulations with a radiative transfer code to create a mock CMD. In contrast to previous assumptions that a pure "fade away" model evolves too slowly to account for the sparsity of galaxies in the "green valley", we demonstrate crossing times of ≲ 1 Gyr. We conclude that no sudden quenching event is necessary to produce such rapid colour transitions.

  4. Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18

    PubMed Central

    Leishman, Erin; Howard, Jeffrey M.; Garcia, Gloria E.; Miao, Qi; Ku, Amy T.; Dekker, Joseph D.; Tucker, Haley; Nguyen, Hoang

    2013-01-01

    Hair follicles cyclically degenerate and regenerate throughout adult life and require regular stem cell activation to drive the cycle. In the resting phase of the hair cycle, hair follicle stem cells are maintained in a quiescent state until they receive signals to proliferate. We found that the forkhead transcription factor Foxp1 is crucial for maintaining the quiescence of hair follicle stem cells. Loss of Foxp1 in skin epithelial cells leads to precocious stem cell activation, resulting in drastic shortening of the quiescent phase of the hair cycle. Conversely, overexpression of Foxp1 in keratinocytes prevents cell proliferation by promoting cell cycle arrest. Finally, through both gain- and loss-of-function studies, we identify fibroblast growth factor 18 (Fgf18) as the key downstream target of Foxp1. We show that exogenously supplied FGF18 can prevent the hair follicle stem cells of Foxp1 null mice from being prematurely activated. As Fgf18 controls the length of the quiescent phase and is a key downstream target of Foxp1, our data strongly suggest that Foxp1 regulates the quiescent stem cell state in the hair follicle stem cell niche by controlling Fgf18 expression. PMID:23946441

  5. Autophagy is required for G₁/G₀ quiescence in response to nitrogen starvation in Saccharomyces cerevisiae.

    PubMed

    An, Zhenyi; Tassa, Amina; Thomas, Collin; Zhong, Rui; Xiao, Guanghua; Fotedar, Rati; Tu, Benjamin P; Klionsky, Daniel J; Levine, Beth

    2014-10-01

    In response to starvation, cells undergo increased levels of autophagy and cell cycle arrest but the role of autophagy in starvation-induced cell cycle arrest is not fully understood. Here we show that autophagy genes regulate cell cycle arrest in the budding yeast Saccharomyces cerevisiae during nitrogen starvation. While exponentially growing wild-type yeasts preferentially arrest in G₁/G₀ in response to starvation, yeasts carrying null mutations in autophagy genes show a significantly higher percentage of cells in G₂/M. In these autophagy-deficient yeast strains, starvation elicits physiological properties associated with quiescence, such as Snf1 activation, glycogen and trehalose accumulation as well as heat-shock resistance. However, while nutrient-starved wild-type yeasts finish the G₂/M transition and arrest in G₁/G 0₀ autophagy-deficient yeasts arrest in telophase. Our results suggest that autophagy is crucial for mitotic exit during starvation and appropriate entry into a G₁/G₀ quiescent state.

  6. LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence

    PubMed Central

    Andrusiak, Matthew G.; Vandenbosch, Renaud; Dick, Fred A.; Park, David S.; Slack, Ruth S.

    2013-01-01

    Neuronal survival is dependent upon the retinoblastoma family members, Rb1 (Rb) and Rb2 (p130). Rb is thought to regulate gene repression, in part, through direct recruitment of chromatin modifying enzymes to its conserved LXCXE binding domain. We sought to examine the mechanisms that Rb employs to mediate cell cycle gene repression in terminally differentiated cortical neurons. Here, we report that Rb loss converts chromatin at the promoters of E2f-target genes to an activated state. We established a mouse model system in which Rb-LXCXE interactions could be induciblely disabled. Surprisingly, this had no effect on survival or gene silencing in neuronal quiescence. Absence of the Rb LXCXE-binding domain in neurons is compatible with gene repression and long-term survival, unlike Rb deficiency. Finally, we are able to show that chromatin activation following Rb deletion occurs at the level of E2fs. Blocking E2f-mediated transcription downstream of Rb loss is sufficient to maintain chromatin in an inactive state. Taken together our results suggest a model whereby Rb-E2f interactions are sufficient to maintain gene repression irrespective of LXCXE-dependent chromatin remodeling. PMID:23574720

  7. Organization of ribosomes and nucleoids in Escherichia coli cells during growth and in quiescence.

    PubMed

    Chai, Qian; Singh, Bhupender; Peisker, Kristin; Metzendorf, Nicole; Ge, Xueliang; Dasgupta, Santanu; Sanyal, Suparna

    2014-04-18

    We have examined the distribution of ribosomes and nucleoids in live Escherichia coli cells under conditions of growth, division, and in quiescence. In exponentially growing cells translating ribosomes are interspersed among and around the nucleoid lobes, appearing as alternative bands under a fluorescence microscope. In contrast, inactive ribosomes either in stationary phase or after treatment with translation inhibitors such as chloramphenicol, tetracycline, and streptomycin gather predominantly at the cell poles and boundaries with concomitant compaction of the nucleoid. However, under all conditions, spatial segregation of the ribosomes and the nucleoids is well maintained. In dividing cells, ribosomes accumulate on both sides of the FtsZ ring at the mid cell. However, the distribution of the ribosomes among the new daughter cells is often unequal. Both the shape of the nucleoid and the pattern of ribosome distribution are also modified when the cells are exposed to rifampicin (transcription inhibitor), nalidixic acid (gyrase inhibitor), or A22 (MreB-cytoskeleton disruptor). Thus we conclude that the intracellular organization of the ribosomes and the nucleoids in bacteria are dynamic and critically dependent on cellular growth processes (replication, transcription, and translation) as well as on the integrity of the MreB cytoskeleton.

  8. Tridimensional Thermonuclear Instability in Subignited Plasmas and on the Surface of the Pulsars

    NASA Astrophysics Data System (ADS)

    Cardinali, A.; Coppi, B.

    2016-10-01

    Tridimensional modes involving an increase of the electron temperature can be excited as a result of α-particle heating in subignited D-T fusion burning plasmas when a nearly time- independent external source of heating is applied. The analyzed modes are shown to emerge from an axisymmetric toroidal configurations and are radially localized around rational magnetic surfaces corresponding to q(r =r0) =m0 /n0 where m0 and n0 are the relevant poloidal and toroidal mode numbers. The radial width of the mode is of the order of the thermal scale distances δT =D⊥e th /D∥e th 1/4 (R0 /n0) 1/2(dlnq/dr)0-1/2. The mode has a rather severe damping rate, that has to be overcome by the relevant heating rate. Thus the temperature range to be considered is that where the D-T plasma reactivity undergoes a relatively large increase as a function of temperature. This kind of theory has been applied to the plasmas that are envisioned to be associated with surface of pulsar and be subjects to (spatially) inhomogenous thermonuclear burning. Sponsored in part by the US DOE.

  9. Beryllium deposition on International Thermonuclear Experimental Reactor first mirrors: Layer morphology and influence on mirror reflectivity

    SciTech Connect

    De Temmerman, G.; Baldwin, M. J.; Doerner, R. P.; Nishijima, D.; Seraydarian, R.; Schmid, K.; Kost, F.; Linsmeier, Ch.; Marot, L.

    2007-10-15

    Metallic mirrors will be essential components of the optical diagnostic systems in the International Thermonuclear Experimental Reactor (ITER). Reliability of these systems may be affected by mirror reflectivity changes induced by erosion and/or deposition of impurities (carbon, beryllium). The present study aims to assess the effect of beryllium (Be) deposition on the reflectivity of metallic mirrors and to collect data on the optical quality of these layers in terms of morphology, roughness, etc. Mirrors from molybdenum and copper were exposed in the PISCES-B linear plasma device to collect eroded material from graphite and beryllium targets exposed to beryllium-seeded deuterium plasma. After exposure, relative reflectivity of the mirrors was measured and different surface analysis techniques were used to investigate the properties of the deposited layers. Be layers formed in PISCES-B exhibit high levels of porosity which makes the reflectivity of the Be layers much lower than the reflectivity of pure Be. It is found that if Be deposition occurs on ITER first mirrors, the reflectivity of the coated mirrors will strongly depend on the layer morphology, which in turn depends on the deposition conditions.

  10. Requirements for US regulatory approval of the International Thermonuclear Experimental Reactor (ITER)

    SciTech Connect

    Petti, D.A.; Haire, J.C.

    1993-12-01

    The International Thermonuclear Experimental Reactor (ITER) is the first fusion machine that will have sufficient decay heat and activation product inventory to pose potential nuclear safety concerns. As a result, nuclear safety and environmental issues will be much more important in the approval process for the design, siting, construction, and operation of ITER in the United States than previous fusion devices, such as the Tokamak Fusion Test Reactor. The purpose of this report is (a) to provide an overview of the regulatory approval process for a Department of Energy (DOE) nuclear facility; (b) to present the dose limits used by DOE to protect workers, the public, and the environment from the risks of exposure to radiation and hazardous materials; (c) to discuss some key nuclear safety-related issues that must be addressed early in the Engineering Design Activities (EDA) to obtain regulatory approval; and (d) to provide general guidelines to the ITER Joint Central Team (JCT) concerning the development of a regulatory framework for the ITER project.

  11. Thermonuclear targets for direct-drive ignition by a megajoule laser pulse

    SciTech Connect

    Bel’kov, S. A.; Bondarenko, S. V.; Vergunova, G. A.; Garanin, S. G.; Gus’kov, S. Yu. Demchenko, N. N.; Doskoch, I. Ya.; Kuchugov, P. A.; Zmitrenko, N. V.; Rozanov, V. B.; Stepanov, R. V.; Yakhin, R. A.

    2015-10-15

    Central ignition of a thin two-layer-shell fusion target that is directly driven by a 2-MJ profiled pulse of Nd laser second-harmonic radiation has been studied. The parameters of the target were selected so as to provide effective acceleration of the shell toward the center, which was sufficient for the onset of ignition under conditions of increased hydrodynamic stability of the ablator acceleration and compression. The aspect ratio of the inner deuterium-tritium layer of the shell does not exceed 15, provided that a major part (above 75%) of the outer layer (plastic ablator) is evaporated by the instant of maximum compression. The investigation is based on two series of numerical calculations that were performed using one-dimensional (1D) hydrodynamic codes. The first 1D code was used to calculate the absorption of the profiled laser-radiation pulse (including calculation of the total absorption coefficient with allowance for the inverse bremsstrahlung and resonance mechanisms) and the spatial distribution of target heating for a real geometry of irradiation using 192 laser beams in a scheme of focusing with a cubo-octahedral symmetry. The second 1D code was used for simulating the total cycle of target evolution under the action of absorbed laser radiation and for determining the thermonuclear gain that was achieved with a given target.

  12. Economic impacts on the United States of siting decisions for the international thermonuclear experimental reactor

    SciTech Connect

    Peerenboom, J.P.; Hanson, M.E.; Huddleston, J.R.

    1996-08-01

    This report presents the results of a study that examines and compares the probable short-term economic impacts of the International Thermonuclear Experimental Reactor (ITER) on the United States (U.S.) if (1) ITER were to be sited in the U.S., or (2) ITER were to be sited in one of the other countries that, along with the U.S., is currently participating in the ITER program. Life-cycle costs associated with ITER construction, operation, and decommissioning are analyzed to assess their economic impact. A number of possible U.S. host and U.S. non-host technology and cost-sharing arrangements with the other ITER Parties are examined, although cost-sharing arrangements and the process by which the Parties will select a host country and an ITER site remain open issues. Both national and local/regional economic impacts, as measured by gross domestic product, regional output, employment, net exports, and income, are considered. These impacts represent a portion of the complex, interrelated set of economic considerations that characterize U.S. host and U.S. non-host participation in ITER. A number of other potentially important economic and noneconomic considerations are discussed qualitatively.

  13. Approximating the r-Process on Earth with Thermonuclear Explosions. Lessons Learned and Unanswered Questions

    SciTech Connect

    Becker, Stephen Allan

    2016-01-28

    During the astrophysical r-process, multiple neutron captures occur so rapidly on target nuclei that their daughter nuclei generally do not have time to undergo radioactive decay before another neutron is captured. The r-process can be approximately simulated on Earth in certain types of thermonuclear explosions through an analogous process of rapid neutron captures known as the "prompt capture" process. Between 1952 and 1969, 23 nuclear tests were fielded by the US which were involved (at least partially) with the "prompt capture" process. Of these tests, 15 were at least partially successful. Some of these tests were conducted under the Plowshare Peaceful Nuclear Explosion Program as scientific research experiments. It is now known that the USSR conducted similar nuclear tests during 1966 to 1979. The elements einsteinium and fermium were first discovered by this process. The most successful tests achieved 19 successive neutron captures on the initial target nuclei. A review of the US program, target nuclei used, heavy element yields, scientific achievements of the program, and how some of the results have been used by the astrophysical community is given. Finally, some unanswered questions concerning very neutron-rich nuclei that could potentially have been answered with additional nuclear experiments is presented.

  14. First application of a TES microcalorimeter to a thermonuclear fusion plasma experiment

    NASA Astrophysics Data System (ADS)

    Shinozaki, K.; Hoshino, A.; Ishisaki, Y.; Morita, U.; Ohashi, T.; Mihara, T.; Mitsuda, K.; Tanaka, K.; Yagi, Y.; Koguchi, H.; Hirano, Y.; Sakakita, H.

    2006-04-01

    We report the first application of a superconductive transition edge sensor (TES) microcalorimeter to a thermonuclear fusion plasma experiment in the toroidal pinch experiment RX (TPE-RX). The TES microcalorimeter was installed in a portable adiabatic demagnetization refrigerator (ADR), which is originally designed for a rocket experiment. The ADR was directly connected to TPE-RX with a vacuum duct, and thin Toray-Lumirror or parylene films were used for entrance windows to allow soft X-rays coming into the detector with good efficiency. The detector box was designed to shield the strong magnetic field produced by ADR and TPE-RX. A total of 3472 counts of X-ray signals were detected in 0.2-3.0 keV for 210 plasma shots during the flat-top phase (35-70 ms) after discarding pile-up events. Combining the data with that measured in the energy range of 1.3-8 keV using a SiLi detector, we examined a wide band X-ray spectrum of the plasma. The obtained spectrum is dominated by thermal plasma emission, although at least four different temperature components are required to account for the whole band spectral shape. Impurities in the deuterium plasma are also investigated.

  15. Hydrodynamic Simulation of Frontal Collision of Two Identical Plane Thermonuclear Burning Waves

    NASA Astrophysics Data System (ADS)

    Khishchenko, Konstantin V.; Charakhch'yan, Alexander A.

    2013-10-01

    A one-dimensional problem on synchronous bilateral action of two identical drivers on opposite surfaces of a plane layer of DT fuel with the normal or five times greater initial density is simulated numerically. The solution of the problem includes two thermonuclear burn waves propagating to collide with each other at the symmetry plane. A laser pulse with total absorption of energy at the critical density and a proton bunch that provides for a nearly isochoric heating are considered as drivers. A wide-range equation of state for the fuel, electron and ion heat conduction, self-radiation of plasma and plasma heating by α-particles are taken into account. In spite of different ways of ignition, various models of α-particle heat, whether the burning wave remains slow or transforms into the detonation wave, and regardless of way of such a transformation, the final value of the burn-up factor depends essentially on the only parameter Hρ0 , where H is the half-thickness of the layer and ρ0 is the initial fuel density. This factor is about 0.35 at Hρ0 ~ 1 g/cm2 and about 0.7 at Hρ0 ~ 5 g/cm2.

  16. Thermal-hydraulic design issues and analysis for the ITER (International Thermonuclear Experimental Reactor) divertor

    SciTech Connect

    Koski, J.A.; Watson, R.D. ); Hassanien, A.M. ); Goranson, P.L. . Fusion Engineering Design Center); Salmonson, J.C. . Special Projects)

    1990-01-01

    Critical Heat Flux (CHF), also called burnout, is one of the major design limits for water-cooled divertors in tokamaks. Another important design issue is the correct thermal modeling of the divertor plate geometry where heat is applied to only one side of the plate and highly subcooled flow boiling in internal passages is used for heat removal. This paper discusses analytical techniques developed to address these design issues, and the experimental evidence gathered in support of the approach. Typical water-cooled divertor designs for the International Thermonuclear Experimental Reactor (ITER) are analyzed, and design margins estimated. Peaking of the heat flux at the tube-water boundary is shown to be an important issue, and design concerns which could lead to imposing large design safety margins are identified. The use of flow enhancement techniques such as internal twisted tapes and fins are discussed, and some estimates of the gains in the design margin are presented. Finally, unresolved issues and concerns regarding hydraulic design of divertors are summarized, and some experiments which could help the ITER final design process identified. 23 refs., 10 figs.

  17. Economic Impacts on the United States of Siting Decisions for the International Thermonuclear Experimental Reactor

    NASA Astrophysics Data System (ADS)

    Peerenboom, J. P.; Hanson, M. E.; Huddleston, J. R.; Wolsko, T. D.

    1997-12-01

    This paper presents the results of a study that examines and compares the probable short-term economic impacts of the International Thermonuclear Experimental Reactor (ITER) on the United States (U.S.) if (1) ITER were to be sited in the U.S., or (2) ITER were to be sited in one of the other countries that, along with the U.S., is currently participating in the ITER program. Life-cycle costs associated with ITER construction, operation, and decommissioning are analyzed to assess their economic impact. A number of possible U.S. host and U.S. non-host technology and cost-sharing arrangements with the other ITER Parties are examined, although cost-sharing arrangements and the process by which the Parties will select a host country and an ITER site remain open issues. Both national and local/regional economic impacts, as measured by gross domestic product, regional output, employment, net exports, and income, are considered. These impacts represent a portion of the complex, interrelated set of economic considerations that characterize U.S. host and U.S. non-host participation in ITER. A number of other potentially important economic and noneconomic considerations are discussed qualitatively.

  18. Bulk-bronzied graphites for plasma-facing components in ITER (International Thermonuclear Experimental Reactor)

    SciTech Connect

    Hirooka, Y.; Conn, R.W.; Doerner, R.; Khandagle, M. . Inst. of Plasma and Fusion Research); Causey, R.; Wilson, K. ); Croessmann, D.; Whitley, J. ); Holland, D.; Smolik, G. ); Matsuda, T.; Sogabe, T. (Toyo Tanso Co. Ltd., O

    1990-06-01

    Newly developed bulk-boronized graphites and boronized C-C composites with a total boron concentration ranging from 1 wt % to 30 wt % have been evaluated as plasma-facing component materials for the International Thermonuclear Experimental Reactor (ITER). Bulk-boronized graphites have been bombarded with high-flux deuterium plasmas at temperatures between 200 and 1600{degree}C. Plasma interaction induced erosion of bulk-boronized graphites is observed to be a factor of 2--3 smaller than that of pyrolytic graphite, in regimes of physical sputtering, chemical sputtering and radiation enhanced sublimation. Postbombardment thermal desorption spectroscopy indicates that bulk-boronized graphites enhance recombinative desorption of deuterium, which leads to a suppression of the formation of deuterocarbon due to chemical sputtering. The tritium inventory in graphite has been found to decrease by an order of magnitude due to 10 wt % bulk-boronization at temperatures above 1000{degree}C. The critical heat flux to induce cracking for bulk-boronized graphites has been found to be essentially the same as that for non-boronized graphites. Also, 10 wt % bulk-boronization of graphite hinders air oxidation nearly completely at 800{degree}C and reduces the steam oxidation rate by a factor of 2--3 at around 1100 and 1350{degree}C. 38 refs., 5 figs.

  19. Approximating the r-Process on Earth with Thermonuclear Explosions: Lessons Learned and Unanswered Questions

    NASA Astrophysics Data System (ADS)

    Becker, S. A.

    During the astrophysical r-process, multiple neutron captures occur so rapidly on target nuclei that their daughter nuclei generally do not have time to undergo radioactive decay before another neutron is captured. The r-process can be approximately simulated on Earth in certain types of thermonuclear explosions through an analogous process of rapid neutron captures known as the "prompt capture" process. Between 1952 and 1969, 23 nuclear tests were fielded by the US which were involved (at least partially) with the "prompt capture" process. Of these tests, 15 were at least partially successful. Some of these tests were conducted under the Plowshare Peaceful Nuclear Explosion Program as scientific research experiments. It is now known that the USSR conducted similar nuclear tests during 1966 to 1979. The elements einsteinium and fermium were first discovered by this process. The most successful tests achieved 19 successive neutron captures on the initial target nuclei. A review of the US program, target nuclei used, heavy element yields, scientific achievements of the program, and how some of the results have been used by the astrophysical community is given. Finally, some unanswered questions concerning very neutron-rich nuclei that could potentially have been answered with additional nuclear experiments is presented.

  20. Vulnerability assessment of a space based weapon platform electronic system exposed to a thermonuclear weapon detonation

    NASA Astrophysics Data System (ADS)

    Perez, C. L.; Johnson, J. O.

    Rapidly changing world events, the increased number of nations with inter-continental ballistic missile capability, and the proliferation of nuclear weapon technology will increase the number of nuclear threats facing the world today. Monitoring these nation's activities and providing an early warning and/or intercept system via reconnaissance and surveillance satellites and space based weapon platforms is a viable deterrent against a surprise nuclear attack. However, the deployment of satellite and weapon platform assets in space will subject the sensitive electronic equipment to a variety of natural and man-made radiation environments. These include Van Allen Belt protons and electrons; galactic and solar flare protons; and neutrons, gamma rays, and x-rays from intentionally detonated fission and fusion weapons. In this paper, the MASH vl.0 code system is used to estimate the dose to the critical electronics components of an idealized space based weapon platform from neutron and gamma-ray radiation emitted from a thermonuclear weapon detonation in space. Fluence and dose assessments were performed for the platform fully loaded, and in several stages representing limited engagement scenarios. The results indicate vulnerabilities to the Command, Control, and Communication bay instruments from radiation damage for a nuclear weapon detonation for certain source/platform orientations. The distance at which damage occurs will depend on the weapon yield (n,(gamma)/kiloton) and size (kilotons).

  1. Pregabalin Versus Pramipexole: Effects on Sleep Disturbance in Restless Legs Syndrome

    PubMed Central

    Garcia-Borreguero, Diego; Patrick, Jeffrey; DuBrava, Sarah; Becker, Philip M.; Lankford, Alan; Chen, Crystal; Miceli, Jeffrey; Knapp, Lloyd; Allen, Richard P.

    2014-01-01

    Study Objectives: To compare pregabalin versus placebo and pramipexole for reducing restless legs syndrome (RLS)-related sleep disturbance. Design: Randomized, double-blinded, crossover trial. Setting: Twenty-three US sleep centers. Participants: Eighty-five individuals with moderate to severe idiopathic RLS and associated sleep disturbance. Interventions: Participants were randomized across 6 treatment sequences comprising three 4-week periods on pregabalin 300 mg/day (n = 75), pramipexole 0.5 mg/day (n = 76), or placebo (n = 73). Measurements and Results: Polysomnography was conducted over 2 nights at the end of each period. Primary (wake after sleep onset [WASO], pregabalin vs placebo) and key secondary endpoints were analyzed for statistical significance, with descriptive statistics for other endpoints. Pregabalin improved sleep maintenance, demonstrated by reductions in WASO (-27.1 min vs placebo [P < 0.0001]; -26.9 vs pramipexole) and number of awakenings after sleep onset (-2.7 vs placebo; -7.9 vs pramipexole [P < 0.0001]) by polysomnography, and an increase in subjective total sleep time (30.8 min vs placebo [P < 0.0001]; 26.8 vs pramipexole). Pregabalin also increased slow wave sleep duration (20.9 min vs placebo; 32.1 vs pramipexole [P < 0.0001]). Reduction in periodic limb movement arousal index (PLMAI) with pregabalin was similar to pramipexole and greater than placebo (-3.7 PLMA/h [P < 0.0001]), although reduction in total PLM in sleep was less than for pramipexole. Conclusions: This study demonstrated improvements in objective and subjective measures of sleep maintenance and sleep architecture with pregabalin compared with placebo and pramipexole. Effects of pregabalin on periodic limb movement arousal index were comparable to pramipexole. Trial Registration: ClinicalTrials.gov identifier, NCT00991276; http://clinicaltrials.gov/show/NCT00991276 Citation: Garcia-Borreguero D; Patrick J; DuBrava S; Becker PM; Lankford A; Chen C; Miceli J; Knapp L; Allen

  2. Multicenter Case-Control Study on Restless Legs Syndrome in Multiple Sclerosis: the REMS Study

    PubMed Central

    Manconi, Mauro; Ferini-Strambi, Luigi; Filippi, Massimo; Bonanni, Enrica; Iudice, Alfonso; Murri, Luigi; Gigli, Gian Luigi; Fratticci, Lara; Merlino, Giovanni; Terzano, Giovanni; Granella, Franco; Parrino, Liborio; Silvestri, Rosalia; Aricò, Irene; Dattola, Vincenzo; Russo, Giovanna; Luongo, Carmela; Cicolin, Alessandro; Tribolo, Antonella; Cavalla, Paola; Savarese, Mariantonietta; Trojano, Maria; Ottaviano, Salvatore; Cirignotta, Fabio; Simioni, Valentina; Salvi, Fabrizio; Mondino, Fiorella; Perla, Franco; Chinaglia, Giorgia; Zuliani, Cristina; Cesnik, Edward; Granieri, Enrico; Placidi, Fabio; Palmieri, Maria Giuseppina; Manni, Raffaele; Terzaghi, Michele; Bergamaschi, Roberto; Rocchi, Raffaele; Ulivelli, Monica; Bartalini, Sabina; Ferri, Raffaele; Fermo, Salvatore Lo; Ubiali, Emilio; Viscardi, Massimo; Rottoli, Mariarosa; Nobili, Lino; Protti, Alessandra; Ferrillo, Franco; Allena, Marta; Mancardi, Gianluigi; Guarnieri, Biancamaria; Londrillo, Francesco

    2008-01-01

    Study objectives: To verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors. Design: Prospective, multicenter, case-control epidemiologic survey. Settings: Twenty sleep centers certified by the Italian Association of Sleep Medicine. Patients: Eight hundred and sixty-one patients affected by MS and 649 control subjects. Interventions: N/A. Measures and results: Data regarding demographic and clinical factors, presence and severity of RLS, the results of hematologic tests, and visual analysis of cerebrospinal magnetic resonance imaging studies were collected. The prevalence of RLS was 19% in MS and 4.2% in control subjects, with a risk to be affected by RLS of 5.4 (95%confidence interval: 3.56–8.26) times greater for patients with MS than for control subjects. In patients with MS, the following risk factors for RLS were significant: older age; longer MS duration; the primary progressive MS form; higher global, pyramidal, and sensory disability; and the presence of leg jerks before sleep onset. Patients with MS and RLS more often had sleep complaints and a higher intake of hypnotic medications than patients with MS without RLS. RLS associated with MS was more severe than that of control subjects. Conclusions: RLS is significantly associated with MS, especially in patients with severe pyramidal and sensory disability. These results strengthen the idea that the inflammatory damage correlated with MS may induce a secondary form of RLS. As it does in idiopathic cases, RLS has a significant impact on sleep quality in patients with MS; therefore, it should be always searched for, particularly in the presence of insomnia unresponsive to treatment with common hypnotic drugs. Citation: Manconi M; Ferini-Strambi L; Filippi M; Bonanni E; Iudice A; Murri L; Gigli GL; Fratticci L; Merlino G; Terzano G; Granella F; Parrino L; Silvestri R; Aricò I; Dattola V; Russo G; Luongo

  3. A Four-Year Longitudinal Study on Restless Legs Syndrome in Parkinson Disease

    PubMed Central

    Moccia, Marcello; Erro, Roberto; Picillo, Marina; Santangelo, Gabriella; Spina, Emanuele; Allocca, Roberto; Longo, Katia; Amboni, Marianna; Palladino, Raffaele; Assante, Roberta; Pappatà, Sabina; Pellecchia, Maria Teresa; Barone, Paolo; Vitale, Carmine

    2016-01-01

    Study Objectives: Restless legs syndrome (RLS) prevalence estimates range from 0% to 52% in Parkinson disease (PD), but the causal relationship between the two disorders is still debated. The present study aims to evaluate RLS prevalence in de novo PD subjects, its incidence during the first 4 years from diagnosis, and possible relationships with clinical, laboratory, and neuroradiological data. Methods: One hundred nine newly diagnosed, drug-naïve PD subjects were evaluated at the time of PD diagnosis, and after 2- and 4-years. RLS diagnosis was performed with the RLS Diagnostic Index at each visit. Motor features, additional non-motor symptoms (NMS), and concomitant dopaminergic and nondopaminergic treatments were also gathered. Moreover, at baseline, 65 subjects were randomly selected to undergo a FP-CIT SPECT to study dopamine transporter availability. Results: RLS prevalence rose from 4.6% at baseline evaluation to 6.5% after 2 years and to 16.3% after 4 years (P = 0.007). A multinomial logistic stepwise regression model selected NMS Questionnaire items more likely to be associated with RLS at diagnosis (insomnia, OR = 15.555; P = 0.040) and with occurrence of RLS during follow-up (dizziness, OR = 1.153; P = 0.022; and daytime sleepiness; OR = 9.557; P = 0.001), as compared to patients without RLS. Older age was more likely associated to increased RLS occurrence during follow-up in a random effect logistic regression model (OR = 1.187; P = 0.036). A multinomial logistic stepwise model found increased dopaminergic transporter availability of affected caudate and putamen to be more likely associated with RLS presence at diagnosis (n = 5; OR = 75.711; P = 0.077), and RLS occurrence during follow-up (n = 16; OR = 12.004; P = 0.059), respectively, as compared to patients without RLS (n = 88). Conclusions: RLS is present since PD diagnosis, and increases in prevalence during the course of PD. PD subjects with RLS have higher age at PD onset, more preserved

  4. Characterization of cardiac quiescence from retrospective cardiac computed tomography using a correlation-based phase-to-phase deviation measure

    PubMed Central

    Wick, Carson A.; McClellan, James H.; Arepalli, Chesnal D.; Auffermann, William F.; Henry, Travis S.; Khosa, Faisal; Coy, Adam M.; Tridandapani, Srini

    2015-01-01

    Purpose: Accurate knowledge of cardiac quiescence is crucial to the performance of many cardiac imaging modalities, including computed tomography coronary angiography (CTCA). To accurately quantify quiescence, a method for detecting the quiescent periods of the heart from retrospective cardiac computed tomography (CT) using a correlation-based, phase-to-phase deviation measure was developed. Methods: Retrospective cardiac CT data were obtained from 20 patients (11 male, 9 female, 33–74 yr) and the left main, left anterior descending, left circumflex, right coronary artery (RCA), and interventricular septum (IVS) were segmented for each phase using a semiautomated technique. Cardiac motion of individual coronary vessels as well as the IVS was calculated using phase-to-phase deviation. As an easily identifiable feature, the IVS was analyzed to assess how well it predicts vessel quiescence. Finally, the diagnostic quality of the reconstructed volumes from the quiescent phases determined using the deviation measure from the vessels in aggregate and the IVS was compared to that from quiescent phases calculated by the CT scanner. Three board-certified radiologists, fellowship-trained in cardiothoracic imaging, graded the diagnostic quality of the reconstructions using a Likert response format: 1 = excellent, 2 = good, 3 = adequate, 4 = nondiagnostic. Results: Systolic and diastolic quiescent periods were identified for each subject from the vessel motion calculated using the phase-to-phase deviation measure. The motion of the IVS was found to be similar to the aggregate vessel (AGG) motion. The diagnostic quality of the coronary vessels for the quiescent phases calculated from the aggregate vessel (PAGG) and IVS (PIV S) deviation signal using the proposed methods was comparable to the quiescent phases calculated by the CT scanner (PCT). The one exception was the RCA, which improved for PAGG for 18 of the 20 subjects when compared to PCT (PCT = 2.48; PAGG = 2.07, p = 0

  5. Characterization of cardiac quiescence from retrospective cardiac computed tomography using a correlation-based phase-to-phase deviation measure

    SciTech Connect

    Wick, Carson A.; McClellan, James H.; Arepalli, Chesnal D.; Auffermann, William F.; Henry, Travis S.; Khosa, Faisal; Coy, Adam M.; Tridandapani, Srini

    2015-02-15

    Purpose: Accurate knowledge of cardiac quiescence is crucial to the performance of many cardiac imaging modalities, including computed tomography coronary angiography (CTCA). To accurately quantify quiescence, a method for detecting the quiescent periods of the heart from retrospective cardiac computed tomography (CT) using a correlation-based, phase-to-phase deviation measure was developed. Methods: Retrospective cardiac CT data were obtained from 20 patients (11 male, 9 female, 33–74 yr) and the left main, left anterior descending, left circumflex, right coronary artery (RCA), and interventricular septum (IVS) were segmented for each phase using a semiautomated technique. Cardiac motion of individual coronary vessels as well as the IVS was calculated using phase-to-phase deviation. As an easily identifiable feature, the IVS was analyzed to assess how well it predicts vessel quiescence. Finally, the diagnostic quality of the reconstructed volumes from the quiescent phases determined using the deviation measure from the vessels in aggregate and the IVS was compared to that from quiescent phases calculated by the CT scanner. Three board-certified radiologists, fellowship-trained in cardiothoracic imaging, graded the diagnostic quality of the reconstructions using a Likert response format: 1 = excellent, 2 = good, 3 = adequate, 4 = nondiagnostic. Results: Systolic and diastolic quiescent periods were identified for each subject from the vessel motion calculated using the phase-to-phase deviation measure. The motion of the IVS was found to be similar to the aggregate vessel (AGG) motion. The diagnostic quality of the coronary vessels for the quiescent phases calculated from the aggregate vessel (P{sub AGG}) and IVS (P{sub IV} {sub S}) deviation signal using the proposed methods was comparable to the quiescent phases calculated by the CT scanner (P{sub CT}). The one exception was the RCA, which improved for P{sub AGG} for 18 of the 20 subjects when compared to P

  6. Prevalence of restless legs syndrome in Ankara, Turkey: an analysis of diagnostic criteria and awareness.

    PubMed

    Yilmaz, Nesrin Helvaci; Akbostanci, Muhittin Cenk; Oto, Aycan; Aykac, Ozlem

    2013-09-01

    The aim of this study was threefold: (1) to investigate the prevalence of restless legs syndrome (RLS), in Ankara, Turkey; (2) to determine the predictive values of diagnostic criteria; and (3) to determine the frequency of physician referrals and the frequency of getting the correct diagnosis. A total of 815 individuals, from randomly selected addresses, above the age of 15, were reached using the questionnaire composed of the four diagnostic criteria. Individuals who responded by answering 'yes' for at least one question were interviewed by neurologists for the diagnosis of RLS. Frequency of physician referrals and frequency of getting the correct diagnosis of RLS were also determined for patients getting the final diagnoses of RLS. Prevalence of RLS in Ankara was 5.52 %; 41.0 % of the individuals diagnosed with RLS had replied 'yes' to either one, two or three questions asked by interviewers. However, only 21.3 % of individuals who replied 'yes' to all four questions received the diagnosis of RLS. Among the patients who had the final diagnosis of RLS, 25.7 % had referred to a physician for the symptoms and 22.2 % got the correct diagnosis. The RLS prevalence in Ankara was somewhere between Western and Far East countries compatible with the geographical location. Diagnostic criteria may not be fully predictive when applied by non-physician pollsters. Physician's probability of correctly diagnosing RLS is still low.

  7. The pharmacological treatment for uremic restless legs syndrome: evidence-based review.

    PubMed

    de Oliveira, Márcio Moysés; Conti, Cristiane Fiquene; Valbuza, Juliana Spelta; de Carvalho, Luciane Bizari Coin; do Prado, Gilmar Fernandes

    2010-07-30

    Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi-randomized double-blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta-analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic-associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed.

  8. Assessment of restless legs syndrome--methodological approaches for use in practice and clinical trials.

    PubMed

    Kohnen, Ralf; Allen, Richard P; Benes, Heike; Garcia-Borreguero, Diego; Hening, Wayne A; Stiasny-Kolster, Karin; Zucconi, Marco

    2007-01-01

    The Restless Legs Syndrome (RLS) is a sensorimotor disorder that has only recently been extensively investigated by validated methods. Following the first presentation of diagnostic criteria by the International RLS Study Group in 1995, several methods were specifically developed for clinical trials in RLS or adapted from other areas of medicine and health sciences. We present a critical overview on validated methods to assess (1) severity of RLS symptoms [International RLS Rating Scale (IRLS), John Hopkins RLS Severity Scale (JHRLSSS), the RLS-6 scales, and the investigator-based Clincial Global Impressions (CGI)]; (2) quality of life [RLS Quality of Life Instrument (RLS-QLI), Hopkins RLS Quality of Life Questionnaire (RLSQoL), and the RLS Quality of Life Questionnaire (QoL-RLS)]; (3) sleep disturbances and sudden onset of sleep; (4) sleep laboratory methods (polysomnography, limb activity monitoring by actigraphy) to evaluate sleep and periodic leg movements (including the "suggested immobilization test"); and (5) severity of augmentation (Augmentation Severity Rating Scale, ASRS). It is concluded that several validated methods are available to investigate the main features of RLS in practice and in clinical trials; however, further developments are needed to address new questions like the consequences of RLS on life functioning in areas such as ability to travel, days missed at work or impaired work performance.

  9. Characterization of movements during restless sleep in children: a pilot study.

    PubMed

    Lamprecht, Marnie L; Terrill, Philip I; Parsley, Chloe L; Bradley, Andrew P

    2014-01-01

    Actigraphy is effective at monitoring circadian rhythms, but often misidentifies periods of restless sleep (defined here as sleep periods with movement) as wake, and periods of quiet wake as sleep. This limitation restricts the effectiveness of actigraphy for investigating sleep disorders. Our objective in this study was to investigate a time-frequency representation of movement during sleep and wake which could ultimately aid in improving classification performance by reducing false wake detections. As a pilot study, we investigate the characteristics of manually labelled movements from six patients (aged 6-12 years, 3 male) during sleep and wake using the over complete discrete wavelet decomposition. The difference between the median wavelet coefficients were analyzed for 30 movement segments from six movement categories during sleep and wake. We found that, in general, the temporal location of high energy coefficients and the energy of the high frequency bands differed between movements during sleep and wake. This indicates that we are able to differentiate movement during sleep and wake with a time-frequency representation. This representation may improve the sleep and wake classification performance by identifying movements specific to sleep and wake. This will likely improve the poor specificity inherent in conventional actigraphy.

  10. Nondrug-related aspect of treating Ekbom disease, formerly known as restless legs syndrome

    PubMed Central

    Mitchell, Ulrike H

    2011-01-01

    Ekbom disease (EKD), formerly known as restless legs syndrome (RLS) has affected and bothered many people over the centuries. It is one of the most prevalent neurological disorders in Europe and North-America, affecting about 10% of the population. The main characteristics are the strong urge to move, accompanied or caused by uncomfortable, sometimes even distressing, paresthesia of the legs, described as a “creeping, tugging, pulling” feeling. The symptoms often become worse as the day progresses, leading to sleep disturbances or sleep deprivation, which leads to decreased alertness and daytime functions. Numerous studies have been conducted assessing the efficacy of dopaminergic drugs, opioids, and other pharmacologic agents in alleviating EKD symptoms. However, there is also a growing body of evidence demonstrating the effectiveness of nonpharmacologic treatments including life style changes, physical activity programs, pneumatic compression, massage, near-infrared light therapy, and complementary therapies. The working mechanisms behind these alternatives are diverse. Some increase blood flow to the legs, therefore reducing tissue hypoxia; some introduce an afferent counter stimulus to the cortex and with that “close the gate” for aberrant nerve stimulations; some increase dopamine and nitric oxide and therefore augment bio-available neurotransmitters; and some generate endorphins producing an analgesic effect. The advantages of these treatments compared with pharmacologic agents include less or no side effects, no danger of augmentation, and less cost. PMID:21654870

  11. Restless legs syndrome is a common feature of adult celiac disease.

    PubMed

    Moccia, Marcello; Pellecchia, Maria Teresa; Erro, Roberto; Zingone, Fabiana; Marelli, Sara; Barone, Damiano Giuseppe; Ciacci, Carolina; Strambi, Luigi Ferini; Barone, Paolo

    2010-05-15

    Restless legs syndrome (RLS) is a common neurological condition, frequently idiopathic, sometimes associated with specific disorders such as iron deficiency. We investigated RLS prevalence in celiac disease (CD), an autoimmune disease characterized by several features such as malabsorption-related iron deficiency anemia and peripheral neuropathy. We screened a population of 100 adult CD patients for CD features, iron metabolism, clinical and neurological conditions, and enrolled 100 age- and sex-matched controls in the general population. RLS was ascertained in CD patients and controls by both the presence of the four essential International RLS Study Group diagnostic criteria and neurological examination. The International RLS Study Group rating scale was used to measure RLS severity. We found a 31% prevalence of RLS in the CD population that was significantly higher than the prevalence in the control population (4%; P < 0.001). The average severity of RLS in CD population was moderate (17 +/- 6.5). In the CD population, no significant correlation was found between RLS and either gluten-free diet or iron metabolism, despite hemoglobin levels were significantly lower in CD patients with RLS than without RLS (P = 0.003). We found no correlation between RLS and other possible causes of secondary RLS, including signs of peripheral neuropathy, pregnancy, end-stage renal disease, and pharmacological treatments.Our study broadens the spectrum of neurological disorders associated with CD and indicates that RLS should be sought for in all patients with CD.

  12. Size and accumulation of fuel reserves at stopover predict nocturnal restlessness in a migratory bird.

    PubMed

    Eikenaar, Cas; Schläfke, Jan Laszlo

    2013-01-01

    Early arrival at the breeding site positively affects the breeding success of migratory birds. During migration, birds spend most of their time at stopovers. Therefore, determining which factors shape stopover duration is essential to our understanding of avian migration. Because the main purpose of stopover is to accumulate fat as fuel for the next flight bout, fuel reserves at arrival and the accumulation of fuel are both expected to affect stopover departure decisions. Here, we determined whether fuel reserves and fuel accumulation predict a bird's motivation to depart, as quantified by nocturnal migratory restlessness (Zugunruhe), using northern wheatears (Oenanthe oenanthe) that were captured and temporarily contained at spring stopover. We found that fuel reserves at capture were positively correlated with Zugunruhe, and negatively correlated with fuel accumulation. This indicates that fat birds were motivated to depart, whereas lean birds were set on staying and accumulating fuel. Moreover, the change in fuel reserves was positively correlated with the concurrent change in Zugunruhe, providing the first empirical evidence for a direct link between fuel accumulation and Zugunruhe during stopover. Our study indicates that, together with innate rhythms and weather, the size and accumulation of fuel reserves shape stopover duration, and hence overall migration time.

  13. Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome.

    PubMed

    García-Martín, Elena; Jiménez-Jiménez, Félix Javier; Alonso-Navarro, Hortensia; Martínez, Carmen; Zurdo, Martín; Turpín-Fenoll, Laura; Millán-Pascual, Jorge; Adeva-Bartolomé, Teresa; Cubo, Esther; Navacerrada, Francisco; Rojo-Sebastián, Ana; Rubio, Lluisa; Ortega-Cubero, Sara; Pastor, Pau; Calleja, Marisol; Plaza-Nieto, José Francisco; Pilo-de-la-Fuente, Belén; Arroyo-Solera, Margarita; García-Albea, Esteban; Agúndez, José A G

    2015-08-01

    Several neurochemical, neuropathological, neuroimaging, and experimental data, suggest that iron deficiency plays an important role in the pathophysiology of restless legs syndrome (RLS). Heme-oxygenases (HMOX) are an important defensive mechanism against oxidative stress, mainly through the degradation of heme to biliverdin, free iron, and carbon monoxide. We analyzed whether HMOX1 and HMOX2 genes are related with the risk to develop RLS.We analyzed the distribution of genotypes and allelic frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 SNPs, as well as the presence of Copy number variations (CNVs) of these genes in 205 subjects RLS and 445 healthy controls.The frequencies of rs2071746TT genotype and rs2071746T allelic variant were significantly lower in RLS patients than that in controls, although the other 3 studied SNPs did not differ between RLS patients and controls. None of the studied polymorphisms influenced the disease onset, severity of RLS, family history of RLS, serum ferritin levels, or response to dopaminergic agonist, clonazepam or GABAergic drugs.The present study suggests a weak association between HMOX1 rs2071746 polymorphism and the risk to develop RLS in the Spanish population.

  14. Restless legs syndrome in a population of northern Tanzania: a community-based study.

    PubMed

    Winkler, Andrea Sylvia; Trendafilova, Anna; Meindl, Michael; Kaaya, John; Schmutzhard, Erich; Kassubek, Jan

    2010-04-15

    Restless legs syndrome (RLS) is a highly prevalent movement disorder. However, prevalences seem to vary amongst different ethnicities. To date, no community-based prevalence studies on RLS have been reported from the African continent. We have conducted a community-based, door-to-door study in northern Tanzania. Over a period of 16 months, 7,654 people aged 14 years and older were screened for the RLS Essential Diagnostic Criteria. Sampling was performed according to the method of "multistage cluster sampling." People who screened positive where reinterviewed and physically examined by a specialist neurologist. During the screening phase, 10 people answered "yes" to at least one of the screening questions. After reinterviewing those people, the result was confirmed in five people only. After careful re-evaluation of the results, only one person was diagnosed with RLS. Because of methodological limitations a definite prevalence may only be calculated from larger population-based studies of different African ethnicities with screening questions adapted to the cultural context.

  15. Correlation of anxiety and depression symptoms in patients with restless legs syndrome: a population based survey

    PubMed Central

    Sevim, S; Dogu, O; Kaleagasi, H; Aral, M; Metin, O; Camdeviren, H

    2004-01-01

    Background and objectives: Restless legs syndrome (RLS) is an important and common cause of insomnia, and previous studies indicate that psychiatric wellbeing may be impaired among RLS patients. We aimed to investigate the interaction between anxiety/depression and RLS in a population based survey. Methods: Data were drawn from the Mersin University Neuro-Epidemiology Project, a representative community sample of adults aged over 17 years residing in Mersin (n = 3234). Subjects found to be positive for RLS (n = 103) were evaluated for symptoms of anxiety and depression using the Hamilton Anxiety and Depression Scales and compared with the same number of contemporaneous control subjects. Results: Significantly greater anxiety and depression symptoms were observed among patients with RLS than in the control subjects. Our data also seem to provide initial evidence of a correlation between the severity of RLS and of anxiety and depression symptoms (r = 0.21, p = 0.03 and r = 0.201, p = 0.04 respectively). Conclusions: Assessment of psychiatric status of RLS patients can be helpful and sometimes necessary to determine additional features and treatment strategies of this bothering condition. Further studies are needed to replicate our findings using longitudinal data. PMID:14742594

  16. Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome

    PubMed Central

    García-Martín, Elena; Jiménez-Jiménez, Félix Javier; Alonso-Navarro, Hortensia; Martínez, Carmen; Zurdo, Martín; Turpín-Fenoll, Laura; Millán-Pascual, Jorge; Adeva-Bartolomé, Teresa; Cubo, Esther; Navacerrada, Francisco; Rojo-Sebastián, Ana; Rubio, Lluisa; Ortega-Cubero, Sara; Pastor, Pau; Calleja, Marisol; Plaza-Nieto, José Francisco; Pilo-de-la-Fuente, Belén; Arroyo-Solera, Margarita; García-Albea, Esteban; Agúndez, José A.G.

    2015-01-01

    Abstract Several neurochemical, neuropathological, neuroimaging, and experimental data, suggest that iron deficiency plays an important role in the pathophysiology of restless legs syndrome (RLS). Heme-oxygenases (HMOX) are an important defensive mechanism against oxidative stress, mainly through the degradation of heme to biliverdin, free iron, and carbon monoxide. We analyzed whether HMOX1 and HMOX2 genes are related with the risk to develop RLS. We analyzed the distribution of genotypes and allelic frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 SNPs, as well as the presence of Copy number variations (CNVs) of these genes in 205 subjects RLS and 445 healthy controls. The frequencies of rs2071746TT genotype and rs2071746T allelic variant were significantly lower in RLS patients than that in controls, although the other 3 studied SNPs did not differ between RLS patients and controls. None of the studied polymorphisms influenced the disease onset, severity of RLS, family history of RLS, serum ferritin levels, or response to dopaminergic agonist, clonazepam or GABAergic drugs. The present study suggests a weak association between HMOX1 rs2071746 polymorphism and the risk to develop RLS in the Spanish population. PMID:26313808

  17. Frequent difficulties in the treatment of restless legs syndrome - case report and literature review.

    PubMed

    Narowska, Dominika; Bożek, Milena; Krysiak, Katarzyna; Antczak, Jakub; Holka-Pokorska, Justyna; Jernajczyk, Wojciech; Wichniak, Adam

    2015-01-01

    Restless legs syndrome (RLS) is one of the most common sleep disorders. The purpose of this paper is a case description of the patient suffering from RLS, concurrent with numerous clinical problems. In our patient, during long-term therapy with a dopamine agonist (ropinirole), the phenomenon of the augmentation, defined as an increase in the severity of the RLS symptoms, was observed. The quality of life of the patient was significantly deteriorated. Due to the augmentation of RLS symptoms the dopaminergic drug was gradually withdrawn, and the gabapentin as a second-line drug for the treatment of RLS was introduced. Because of the large increase of both insomnia and RLS symptoms during the reduction of ropinirole dose, clonazepam was temporarily introduced. In addition, in the neurological assessment of the distal parts of the lower limb sensory disturbances of vibration were found. The neurographic study confirmed axonal neuropathy of the sural nerves, which explained an incomplete response to dopaminergic medications. However, gabapentin treatment in the dose recommended in neuropathies was impossible due to bothersome side effects. Another important issue in the treatment of the patient were depressive symptoms and the fact that the majority of used antidepressants (mirtazapine, mianserin, tricyclic antidepressants) increase the severity of RLS. Among antidepressants recommended for the treatment of depression in patients with RLS (such as bupropion, moclobemide, reboxetine, tianeptine and agomelatine) only agomelatine exhibits promoting sleep properties. Because of the concomitant insomnia, this drug was applied in our patient.

  18. Restless legs syndrome in a primary contact setting: a case report

    PubMed Central

    Stupar, Maja

    2008-01-01

    Objective To describe the diagnostic features of a patient who presented to a chiropractor with restless legs syndrome (RLS), a common but often under-diagnosed condition. Clinical Features A 42-year-old male patient presented with twitching and deep pressure in the legs bilaterally; described also as an uncomfortable urge to move the legs that followed a circadian rhythm occurring in the evening. The symptoms were initiated after periods of rest and they were relieved by movement. Physical examination was non-contributory which is common in RLS except in secondary forms of the condition. Discussion The pathophysiology of RLS is still unknown but several treatments have been studied. Non-pharmacologic treatment options include education on improving sleep hygiene, decreasing alcohol and caffeine intake, moderate exercise and supplements. Pharmacological treatment options are available, with L-dopa being the most effective. Conclusion The symptoms of RLS were 65% resolved in the case presented in one month. Awareness and proper diagnosis by all primary contact practitioners is necessary for effective management of RLS. PMID:18516284

  19. Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival

    PubMed Central

    Miller, Daniel L; Myers, Chad L; Rickards, Brenden; Coller, Hilary A; Flint, S Jane

    2007-01-01

    Background Human adenoviruses, such as serotype 5 (Ad5), encode several proteins that can perturb cellular mechanisms that regulate cell cycle progression and apoptosis, as well as those that mediate mRNA production and translation. However, a global view of the effects of Ad5 infection on such programs in normal human cells is not available, despite widespread efforts to develop adenoviruses for therapeutic applications. Results We used two-color hybridization and oligonucleotide microarrays to monitor changes in cellular RNA concentrations as a function of time after Ad5 infection of quiescent, normal human fibroblasts. We observed that the expression of some 2,000 genes, about 10% of those examined, increased or decreased by a factor of two or greater following Ad5 infection, but were not altered in mock-infected cells. Consensus k-means clustering established that the temporal patterns of these changes were unexpectedly complex. Gene Ontology terms associated with cell proliferation were significantly over-represented in several clusters. The results of comparative analyses demonstrate that Ad5 infection induces reversal of the quiescence program and recapitulation of the core serum response, and that only a small subset of the observed changes in cellular gene expression can be ascribed to well characterized functions of the viral E1A and E1B proteins. Conclusion These findings establish that the impact of adenovirus infection on host cell programs is far greater than appreciated hitherto. Furthermore, they provide a new framework for investigating the molecular functions of viral early proteins and information relevant to the design of conditionally replicating adenoviral vectors. PMID:17430596

  20. Ionization and electric field properties of auroral arcs during magnetic quiescence

    SciTech Connect

    Robinson, R.M.; Mende, S.B. )

    1990-12-01

    Studies of the morphology of auroral precipitation during times of magnetic quiescence indicate that the polar cap shrinks and becomes distorted into a teardrop or pear-shaped region. On November 16, 1987, incoherent scatter radar and all-sky imaging photometer measurements were made of auroral arcs over Sondre Stromfjord, Greenland. The arcs were generally oriented in a geographic east-west direction which is approximately Sun aligned at a local time just after dusk. Kp was 1, and the interlplanetary magnetic field was northward during the time of observation, so tha the arcs occurred under magnetically quiet conditions. The Sondrestrom radar measurements were used to determine the electron density and plasma drifts associated with the arcs; the all-sky imaging photometer data were used to relate the radar measurements to the arc morphology. Assuming the arcs were produced by precipitating electrons, the height profiles of electron density indicate average energies less than about 2 keV and energy fluxes of 1 erg/(cm{sup 2}s). F region electron densities were high in the polar cap north of the arcs and low within the region of the arcs. The poleward boundary of the arc system was a convection reversal boundary across which plasma exited the polar cap region moving antisunward and then turned sunward (westward). The observed arc-associated convection is consistent with that expected under these geomagnetic conditions. Comparison of these results with the electrodynamic properties of other arcs observed in the afternoon and early evening suggests that there is a system of arcs that delineates the afternoon convection cell. The observed gradient in F region electron density across the arc can be explained in terms of the recombination of ionization drifting in response to the arc-associated convection pattern.

  1. Reaction rate and composition dependence of the stability of thermonuclear burning on accreting neutron stars

    SciTech Connect

    Keek, L.; Cyburt, R. H.; Heger, A.

    2014-06-01

    The stability of thermonuclear burning of hydrogen and helium accreted onto neutron stars is strongly dependent on the mass accretion rate. The burning behavior is observed to change from Type I X-ray bursts to stable burning, with oscillatory burning occurring at the transition. Simulations predict the transition at a 10 times higher mass accretion rate than observed. Using numerical models we investigate how the transition depends on the hydrogen, helium, and CNO mass fractions of the accreted material, as well as on the nuclear reaction rates of 3α and the hot-CNO breakout reactions {sup 15}O(α, γ){sup 19}Ne and {sup 18}Ne(α, p){sup 21}Na. For a lower hydrogen content the transition is at higher accretion rates. Furthermore, most experimentally allowed reaction rate variations change the transition accretion rate by at most 10%. A factor 10 decrease of the {sup 15}O(α, γ){sup 19}Ne rate, however, produces an increase of the transition accretion rate of 35%. None of our models reproduce the transition at the observed rate, and depending on the true {sup 15}O(α, γ){sup 19}Ne reaction rate, the actual discrepancy may be substantially larger. We find that the width of the interval of accretion rates with marginally stable burning depends strongly on both composition and reaction rates. Furthermore, close to the stability transition, our models predict that X-ray bursts have extended tails where freshly accreted fuel prolongs nuclear burning.

  2. Evidence of thermonuclear flame spreading on neutron stars from burst rise oscillations

    SciTech Connect

    Chakraborty, Manoneeta; Bhattacharyya, Sudip E-mail: sudip@tifr.res.in

    2014-09-01

    Burst oscillations during the rising phases of thermonuclear X-ray bursts are usually believed to originate from flame spreading on the neutron star surface. However, the decrease of fractional oscillation amplitude with rise time, which provides a main observational support for the flame spreading model, have so far been reported from only a few bursts. Moreover, the non-detection and intermittent detections of rise oscillations from many bursts are not yet understood considering the flame spreading scenario. Here, we report the decreasing trend of fractional oscillation amplitude from an extensive analysis of a large sample of Rossi X-ray Timing Explorer Proportional Counter Array bursts from 10 neutron star low-mass X-ray binaries. This trend is 99.99% significant for the best case, which provides, to the best of our knowledge, by far the strongest evidence of such a trend. Moreover, it is important to note that an opposite trend is not found in any of the bursts. The concave shape of the fractional amplitude profiles for all the bursts suggests latitude-dependent flame speeds, possibly due to the effects of the Coriolis force. We also systematically study the roles of low fractional amplitude and low count rate for non-detection and intermittent detections of rise oscillations, and attempt to understand them within the flame spreading scenario. Our results support a weak turbulent viscosity for flame spreading, and imply that burst rise oscillations originate from an expanding hot spot, thus making these oscillations a more reliable tool to constrain the neutron star equations of state.

  3. ON THE CONSISTENCY OF NEUTRON-STAR RADIUS MEASUREMENTS FROM THERMONUCLEAR BURSTS

    SciTech Connect

    Galloway, Duncan K.; Lampe, Nathanael

    2012-03-01

    The radius of neutron stars can in principle be measured via the normalization of a blackbody fitted to the X-ray spectrum during thermonuclear (type-I) X-ray bursts, although few previous studies have addressed the reliability of such measurements. Here we examine the apparent radius in a homogeneous sample of long, mixed H/He bursts from the low-mass X-ray binaries GS 1826-24 and KS 1731-26. The measured blackbody normalization (proportional to the emitting area) in these bursts is constant over a period of up to 60 s in the burst tail, even though the flux (blackbody temperature) decreased by a factor of 60%-75% (30%-40%). The typical rms variation in the mean normalization from burst to burst was 3%-5%, although a variation of 17% was found between bursts observed from GS 1826-24 in two epochs. A comparison of the time-resolved spectroscopic measurements during bursts from the two epochs shows that the normalization evolves consistently through the burst rise and peak, but subsequently increases further in the earlier epoch bursts. The elevated normalization values may arise from a change in the anisotropy of the burst emission or alternatively variations in the spectral correction factor, f{sub c} , of order 10%. Since burst samples observed from systems other than GS 1826-24 are more heterogeneous, we expect that systematic uncertainties of at least 10% are likely to apply generally to measurements of neutron-star radii, unless the effects described here can be corrected for.

  4. Multi-Mode transport modeling of the International Thermonuclear Experimental Reactor (ITER)

    SciTech Connect

    Bateman, G.; Kritz, A.H.; Kinsey, J.E.; Redd, A.J.

    1998-06-01

    Predictions are made for the performance of the International Thermonuclear Experimental Reactor (ITER) [R. Aymar, V. Chuyanov, M. Huguet, R. Parker, and Y. Shimomura, in {ital Proceedings of the Sixteenth International Atomic Energy Agency Fusion Energy Conference, Montr{acute e}al, Canada 1996} (International Atomic Energy Agency, Vienna, 1997), Paper IAEA-CN-64/01-1] design using the Multi-Mode model in the time-dependent one- and one-half-dimensional (1-1/2-D) BALDUR [C. E. Singer {ital et al.}, Comput. Phys. Commun. {bold 49}, 275 (1988)] transport code. This model predicts the temperature and density profiles observed in present-day tokamak experiments more closely on the average than other models currently available. Simulations using the Multi-Mode transport model, with its inherent gyro-Bohm scaling, indicate that ITER will ignite, even with edge temperatures as low as 0.25 keV (L-mode, or low-confinement mode, boundary conditions) or with volume averaged density as low as 0.775{times}10{sup 20}m{sup {minus}3} (just below the Greenwald density limit, when T{sub edge}=0.75keV). The ignition is found to be thermally stable, and the fusion power production is easily controlled by varying plasma density, impurity content, or edge temperatures. The nonequilibrium impurity radiation model used in these simulations predicts that a significant fraction of the fusion power is radiated when conditions are close to marginal ignition. {copyright} {ital 1998 American Institute of Physics.}

  5. First operation with the JET International Thermonuclear Experimental Reactor-like wall

    SciTech Connect

    Neu, R.; Arnoux, G.; Beurskens, M.; Challis, C.; Giroud, C.; Lomas, P.; Maddison, G.; Matthews, G.; Mayoral, M.-L.; Meigs, A.; Rimini, F.; Brezinsek, S. [IEK-4, Association EURATOM and others

    2013-05-15

    To consolidate International Thermonuclear Experimental Reactor (ITER) design choices and prepare for its operation, Joint European Torus (JET) has implemented ITER's plasma facing materials, namely, Be for the main wall and W in the divertor. In addition, protection systems, diagnostics, and the vertical stability control were upgraded and the heating capability of the neutral beams was increased to over 30 MW. First results confirm the expected benefits and the limitations of all metal plasma facing components (PFCs) but also yield understanding of operational issues directly relating to ITER. H-retention is lower by at least a factor of 10 in all operational scenarios compared to that with C PFCs. The lower C content (≈ factor 10) has led to much lower radiation during the plasma burn-through phase eliminating breakdown failures. Similarly, the intrinsic radiation observed during disruptions is very low, leading to high power loads and to a slow current quench. Massive gas injection using a D{sub 2}/Ar mixture restores levels of radiation and vessel forces similar to those of mitigated disruptions with the C wall. Dedicated L-H transition experiments indicate a 30% power threshold reduction, a distinct minimum density, and a pronounced shape dependence. The L-mode density limit was found to be up to 30% higher than for C allowing stable detached divertor operation over a larger density range. Stable H-modes as well as the hybrid scenario could be re-established only when using gas puff levels of a few 10{sup 21} es{sup −1}. On average, the confinement is lower with the new PFCs, but nevertheless, H factors up to 1 (H-Mode) and 1.3 (at β{sub N}≈3, hybrids) have been achieved with W concentrations well below the maximum acceptable level.

  6. The HEAO-A2 soft X-ray survey of cataclysmic variable stars - EX Hydrae during optical quiescence

    NASA Technical Reports Server (NTRS)

    Cordova, F. A.; Riegler, G. R.

    1979-01-01

    Results are reported for HEAO A2 soft X-ray (below 2 keV) scanning observations of the southern dwarf nova EX Hya. An X-ray light curve is presented which shows no apparent orbital modulation. The best-fitting spectral parameters are derived for the source, and the observations are compared with the spectral behavior of the dwarf nova SS Cyg during optical quiescence. The results are discussed in terms of models for X-ray production by accreting white dwarfs.

  7. Restless legs syndrome induced by escitalopram: case report and review of the literature.

    PubMed

    Page, Robert Lee; Ruscin, J Mark; Bainbridge, Jacquelyn L; Brieke, Andreas A

    2008-02-01

    Restless legs syndrome (RLS) is a sensorimotor disorder characterized by distressing sensations deep inside the limbs, typically occurring at bedtime or rest. These paresthesias involve an irresistible urge to move the limb, which provides temporary relief but at the expense of sleep and quality of life. The pathophysiology of RLS has been related to dopaminergic pathway dysfunction, thereby aligning it closely with depression from both pathophysiologic and treatment perspectives. Certain antidepressant drugs, including the selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), may induce or exacerbate RLS. We describe the case of a 34-year-old woman with no history of RLS who came to the emergency department with acute decompensated heart failure. After 7 days of hospitalization, she was waitlisted to receive a heart transplant. Her mood became depressed, and she requested a psychiatric consultation; escitalopram 10 mg at bedtime was started. Within 2 days of starting therapy, she developed very severe (determined by a score based on an RLS symptom rating scale) RLS symptoms, warranting the discontinuation of escitalopram. Within 2 days of stopping therapy, her RLS symptoms improved considerably (rated as mild). One week later, the patient was rechallenged with a lower dose of escitalopram, and her very severe RLS symptoms reappeared. Within 2 days of stopping escitalopram, her RLS symptoms again improved, with complete resolution 1 week later. Using the Naranjo adverse drug reaction probability scale, which assesses the probability of a drug causing an adverse event, the patient's score was 9, indicating a definite adverse drug reaction. Although published case reports have linked fluoxetine, sertraline, citalopram, paroxetine, and mirtazapine to RLS, this is the first report, to our knowledge, of escitalopram as a cause of RLS. Based on this case and additional data published with other SSRIs and SNRIs, we

  8. Psychological distress of patients suffering from restless legs syndrome: a cross-sectional study

    PubMed Central

    2011-01-01

    Background Restless legs syndrome (RLS) is a chronic disorder with substantial impact on quality of life similar to that seen in diabetes mellitus or osteoarthritis. Little is known about the psychological characteristics of RLS patients although psychological factors may contribute to unfavourable treatment outcome. Methods In an observational cross-sectional design, we evaluated the psychological features of 166 consecutive RLS patients from three outpatient clinics, by means of the Symptom Checklist 90-R (SCL-90-R) questionnaire. Additionally, the Beck Depression Inventory-II (BDI-II) and the International RLS Severity Scale (IRLS) were measured. Both treated and untreated patients were included, all patients sought treatment. Results Untreated patients (n = 69) had elevated but normal scores on the SCL-90-R Global Severity Index (GSI; p = 0.002) and on the sub-scales somatisation (p < 0.001), compulsivity (p = 0.003), depression (p = 0.02), and anxiety (p = 0.004) compared with a German representative sample. In the treated group, particularly in those patients who were dissatisfied with their actual treatment (n = 62), psychological distress was higher than in the untreated group with elevated scores for the GSI (p = 0.03) and the sub-scales compulsivity (p = 0.006), depression (p = 0.012), anxiety (p = 0.031), hostility (p = 0.013), phobic anxiety (p = 0.024), and paranoid ideation (p = 0.012). Augmentation, the most serious side effect of dopaminergic, i.e. first-line treatment of RLS, and loss of efficacy were accompanied with the highest psychological distress, as seen particularly in the normative values of the sub-scales compulsivity and anxiety. Generally, higher RLS severity was correlated with higher psychological impairment (p < 0.001). Conclusion Severely affected RLS patients show psychological impairment in multiple psychological domains which has to be taken into account in the treatment regimen. PMID:21933380

  9. Prospective study of obesity, hypertension, high cholesterol, and risk of restless legs syndrome.

    PubMed

    De Vito, Katerina; Li, Yanping; Batool-Anwar, Salma; Ning, Yi; Han, Jiali; Gao, Xiang

    2014-07-01

    Because previous cross-sectional studies suggest an association between metabolic disorders and restless legs syndrome (RLS), we prospectively evaluated whether obesity, hypercholesterolemia, and hypertension were associated with increased risk of RLS. Our study consisted of 42,728 female participants from the Nurses' Health Study II and 12,812 male participants from the Health Professionals Follow-up Study, free of RLS at baseline (2002 for men and 2005 for women), and free of diabetes and arthritis through follow-up (2002-2008 for men and 2005-2009 for women). RLS symptoms were assessed using the International RLS Study Group's standardized questionnaire. We considered RLS symptoms a "case" if the symptoms occurred ≥5 times/month and met International RLS Study Group criteria. We found that obesity was associated with an increased risk RLS among both men and women (P difference for sex >0.5). The pooled multivariate-adjusted odds ratio (OR) for RLS was 1.57 (95% confidence interval [CI]: 1.33-1.85; P trend <0.0001) for body mass index >30 versus ≤23 kg/m(2) and 1.56 (95% CI: 1.29-1.89; P trend = 0.0001) comparing two extreme waist circumference quintiles, adjusting for age, ethnicity, smoking, physical activity, use of antidepressant, and other covariates. A similar significant association was found for high cholesterol; the pooled adjusted OR for total serum cholesterol >240 versus <159 mg/dL was 1.33 (95% CI: 1.11-1.60; P trend = 0.002). There was no significant association between hypertension and RLS risk (adjusted OR: 0.90; 95% CI: 0.79-1.02). In this large, prospective study, we found that obesity and high cholesterol, but not high blood pressure, were significantly associated with an increased risk of developing RLS. © 2014 International Parkinson and Movement Disorder Society.

  10. Oxycodone/Naloxone PR: A Review in Severe Refractory Restless Legs Syndrome.

    PubMed

    Frampton, James E

    2015-06-01

    An oral, fixed-dose combination of prolonged-release (PR) oxycodone with PR naloxone (Targin(®), Targiniq(®), Targinact(®); hereafter referred to as oxycodone/naloxone PR) is approved in Europe for the second-line symptomatic treatment of patients with severe to very severe idiopathic restless legs syndrome (RLS), after failure of dopaminergic therapy. Coadministration of naloxone represents a targeted approach to counteracting opioid-induced bowel dysfunction without compromising therapeutic efficacy; because of its very low oral bioavailability, naloxone blocks the action of oxycodone at opioid receptors locally in the gut. The efficacy of oxycodone/naloxone PR in patients with severe RLS inadequately controlled by previous (mainly dopaminergic) treatment has been demonstrated in RELOXYN, a 12-week, randomized, double-blind study with a 40-week open-label extension. In this pivotal study, oxycodone/naloxone PR significantly improved RLS symptoms compared with placebo from week 2 onwards; a beneficial effect of oxycodone/naloxone PR was maintained through 1 year of treatment. Furthermore, improvements in RLS symptoms in oxycodone/naloxone PR recipients were accompanied by similarly sustained improvements in disease-specific quality of life and subjective sleep variables. Oxycodone/naloxone PR was generally well tolerated, with a treatment-related adverse event profile (e.g. gastrointestinal disorders, CNS disorders, fatigue and pruritus) that was consistent with that expected for opioid therapy. Notably, there were no confirmed cases of augmentation among oxycodone/naloxone PR recipients throughout the course of the study. Results from the well-designed RELOXYN trial have thus demonstrated the value of oxycodone/naloxone PR as a second-line therapy for severe refractory RLS; further investigation of this combination product as a first-line treatment for severe RLS is now warranted.

  11. High prevalence of Dopaminergic Premonitory Symptoms in migraine patients with Restless Legs Syndrome: a pathogenetic link?

    PubMed

    Cologno, Daniela; Cicarelli, Giulio; Petretta, Vittorio; d'Onofrio, Florindo; Bussone, Gennaro

    2008-05-01

    In order to assess the prevalence of Dopaminergic Premonitory Symptoms (DPS) in migraine patients with Restless Legs Syndrome (RLS), we chose migraine patients from a large Italian clinical headache population previously investigated for an association between primary headaches and RLS. We evaluated a total sample of 164 patients with migraine, in particular 114 with migraine without aura (MO), 10 with migraine with aura (MA) and 40 with MO and MA in various combinations between them or with episodic tension-type headache (ETTH), defined as a "mixed group". About 20% of all migraine patients referred at least one of the following DPS: yawning, nausea, somnolence or food craving, confirming data already indicated in the literature. Among migraine patients with RLS (25.6%), DPS were referred from about half of the patients (47.6%) compared to those without RLS (47.6% vs. 13.1%; p<0.001). Based on migraine subtype, patients with MO referred DPS (26.3%) more frequently compared to the MA group and "mixed group" (12.0%, p<0.05), particularly in the presence of RLS (63.0% vs. 20.0%, p<0.01). No statistical differences were found between clinical and demographic data of the subgroups or related to medical conditions investigated (anxiety, depression, sleep disorders, body mass index). It is interesting that the chances of having RLS in migraine patients were more than 5 times higher in the presence of DPS. These results could support a hypothetical dopaminergic imbalance in RLS and migraine, as the dopamine is involved in the pathogenesis of both disorders and it is responsible for the migraine DPS reported above.

  12. Reported bruxism and restless legs syndrome in media personnel with or without irregular shift work.

    PubMed

    Ahlberg, Kristiina; Ahlberg, Jari; Könönen, Mauno; Partinen, Markku; Hublin, Christer; Savolainen, Aslak

    2005-04-01

    A standardized questionnaire was mailed to all employees of the Finnish Broadcasting Company with irregular shift work (n = 750) and to an equal number of randomly selected controls in the same company with regular 8-h daytime work. The questionnaire covered demographic items, employment details, general health experience, physical status, psychosocial status, stress, work satisfaction and performance, tobacco use, bruxism, and restless legs symptoms (RLS). The aim was to investigate among a multiprofessional media personnel the associations between reported bruxism and RLS, while simultaneously controlling the effects of gender, age, tobacco use, shift work, and dissatisfaction with current workshift schedule. The overall response rate was 58.3% (53.7% men). The response rate in the irregular shift work group was 82.3% (56.6% men) and in the regular daytime work group 34.3% (46.7% men). In the bivariate analyses, RLS was more prevalent in workers at either end of the studied age range (p < 0.05). Self-reported frequent bruxism was significantly associated with younger age (p < 0.05). Females reported RLS (11.4%) slightly more often than males (7.7%) (NS). In logistic regression, frequent bruxism (p < 0.05) and older age (p < 0.05) were significantly positively associated with RLS. Dissatisfaction with one's current workshift schedule (p < 0.05) and RLS (p < 0.05) were significantly positively associated with frequent bruxism, while age (p < 0.05) was significantly negatively associated. In conclusion, perceived bruxism may be a sign of a stressful situation or dissatisfaction, while RLS as a more stable trait may in itself negatively affect sleep quality and further enhance the problem.

  13. Intractable restless legs syndrome: role of prolonged-release oxycodone–naloxone

    PubMed Central

    de Biase, Stefano; Valente, Mariarosaria; Gigli, Gian Luigi

    2016-01-01

    Restless legs syndrome (RLS) is a common neurological disorder characterized by an irresistible urge to move the legs accompanied by uncomfortable sensations that occur at night or at time of rest. Pharmacological therapy should be limited to patients who suffer from clinically relevant symptoms. Chronic RLS is usually treated with either a dopamine agonist (pramipexole, ropinirole, rotigotine) or an α2δ calcium-channel ligand (gabapentin, gabapentin enacarbil, pregabalin). Augmentation is the main complication of long-term dopaminergic treatment, and frequently requires a reduction of current dopaminergic dose or a switch to non-dopaminergic medications. Opioids as monotherapy or add-on treatment should be considered when alternative satisfactory regimens are unavailable and the severity of symptoms warrants it. In a recent Phase III trial, oxycodone–naloxone prolonged release (PR) demonstrated a significant and sustained effect on patients with severe RLS inadequately controlled by previous treatments. The adverse-event profile was consistent with the safety profile of opioids. The most frequent adverse events were fatigue, constipation, nausea, headache, hyperhidrosis, somnolence, dry mouth, and pruritus. Adverse events were usually mild or moderate in intensity. No cases of augmentation were reported. Oxycodone–naloxone PR is approved for the second-line symptomatic treatment of adults with severe to very severe idiopathic RLS after failure of dopaminergic treatment. Further studies are needed to evaluate if oxycodone–naloxone PR is equally efficacious as a first-line treatment. Moreover, long-term comparative studies between opioids, dopaminergic drugs and α2δ ligands are needed. PMID:26966363

  14. Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome.

    PubMed

    Quiroz, César; Gulyani, Seema; Ruiqian, Wan; Bonaventura, Jordi; Cutler, Roy; Pearson, Virginia; Allen, Richard P; Earley, Christopher J; Mattson, Mark P; Ferré, Sergi

    2016-12-01

    Deficits of sensorimotor integration with periodic limb movements during sleep (PLMS) and hyperarousal and sleep disturbances in Restless Legs Syndrome (RLS) constitute two pathophysiologically distinct but interrelated clinical phenomena, which seem to depend mostly on alterations in dopaminergic and glutamatergic neurotransmission, respectively. Brain iron deficiency is considered as a main pathogenetic mechanism in RLS. Rodents with brain iron deficiency represent a valuable pathophysiological model of RLS, although they do not display motor disturbances. Nevertheless, they develop the main neurochemical dopaminergic changes found in RLS, such as decrease in striatal dopamine D2 receptor density. On the other hand, brain iron deficient mice exhibit the characteristic pattern of hyperarousal in RLS, providing a tool to find the link between brain iron deficiency and sleep disturbances in RLS. The present study provides evidence for a role of the endogenous sleep-promoting factor adenosine. Three different experimental preparations, long-term (22 weeks) severe or moderate iron-deficient (ID) diets (3- or 7-ppm iron diet) in mice and short-term (3 weeks) severe ID diet (3-ppm iron diet) in rats, demonstrated a significant downregulation (Western blotting in mouse and radioligand binding saturation experiments in rat brain tissue) of adenosine A1 receptors (A1R) in the cortex and striatum, concomitant to striatal D2R downregulation. On the other hand, the previously reported upregulation of adenosine A2A receptors (A2AR) was only observed with severe ID in both mice and rats. The results suggest a key role for A1R downregulation in the PLMS and hyperarousal in RLS.

  15. THE FERMI-GBM X-RAY BURST MONITOR: THERMONUCLEAR BURSTS FROM 4U 0614+09

    SciTech Connect

    Linares, M.; Chakrabarty, D.; Connaughton, V.; Bhat, P. N.; Briggs, M. S.; Preece, R.; Jenke, P.; Kouveliotou, C.; Wilson-Hodge, C. A.; Camero-Arranz, A.; Finger, M.; Paciesas, W. S.; Beklen, E.; Von Kienlin, A.

    2012-12-01

    Thermonuclear bursts from slowly accreting neutron stars (NSs) have proven difficult to detect, yet they are potential probes of the thermal properties of the NS interior. During the first year of a systematic all-sky search for X-ray bursts using the Gamma-ray Burst Monitor aboard the Fermi Gamma-ray Space Telescope we have detected 15 thermonuclear bursts from the NS low-mass X-ray binary 4U 0614+09 when it was accreting at nearly 1% of the Eddington limit. We measured an average burst recurrence time of 12 {+-} 3 days (68% confidence interval) between 2010 March and 2011 March, classified all bursts as normal duration bursts and placed a lower limit on the recurrence time of long/intermediate bursts of 62 days (95% confidence level). We discuss how observations of thermonuclear bursts in the hard X-ray band compare to pointed soft X-ray observations and quantify such bandpass effects on measurements of burst radiated energy and duration. We put our results for 4U 0614+09 in the context of other bursters and briefly discuss the constraints on ignition models. Interestingly, we find that the burst energies in 4U 0614+09 are on average between those of normal duration bursts and those measured in long/intermediate bursts. Such a continuous distribution in burst energy provides a new observational link between normal and long/intermediate bursts. We suggest that the apparent bimodal distribution that defined normal and long/intermediate duration bursts during the last decade could be due to an observational bias toward detecting only the longest and most energetic bursts from slowly accreting NSs.

  16. Quantifying Limits on Replication, Death, and Quiescence of Mycobacterium tuberculosis in Mice

    PubMed Central

    McDaniel, Margaret M.; Krishna, Nitin; Handagama, Winode G.; Eda, Shigetoshi; Ganusov, Vitaly V.

    2016-01-01

    When an individual is exposed to Mycobacterium tuberculosis (Mtb) three outcomes are possible: bacterial clearance, active disease, or latent infection. It is generally believed that most individuals exposed to Mtb become latently infected and carry the mycobacteria for life. How Mtb is maintained during this latent infection remains largely unknown. During an Mtb infection in mice, there is a phase of rapid increase in bacterial numbers in the murine lungs within the first 3 weeks, and then bacterial numbers either stabilize or increase slowly over the period of many months. It has been debated whether the relatively constant numbers of bacteria in the chronic infection result from latent (dormant, quiescent), non-replicating bacteria, or whether the observed Mtb cell numbers are due to balance between rapid replication and death. A recent study of mice, infected with a Mtb strain carrying an unstable plasmid, showed that during the chronic phase, Mtb was replicating at significant rates. Using experimental data from this study and mathematical modeling we investigated the limits of the rates of bacterial replication, death, and quiescence during Mtb infection of mice. First, we found that to explain the data the rates of bacterial replication and death could not be constant and had to decrease with time since infection unless there were large changes in plasmid segregation probability over time. While a decrease in the rate of Mtb replication with time since infection was expected due to depletion of host's resources, a decrease in the Mtb death rate was counterintuitive since Mtb-specific immune response, appearing in the lungs 3–4 weeks after infection, should increase removal of bacteria. Interestingly, we found no significant correlation between estimated rates of Mtb replication and death suggesting the decline in these rates was driven by independent mechanisms. Second, we found that the data could not be explained by assuming that bacteria do not die

  17. Accretion dynamics of EX Lupi in quiescence. The star, the spot, and the accretion column

    NASA Astrophysics Data System (ADS)

    Sicilia-Aguilar, Aurora; Fang, Min; Roccatagliata, Veronica; Collier Cameron, Andrew; Kóspál, Ágnes; Henning, Thomas; Ábrahám, Peter; Sipos, Nikoletta

    2015-08-01

    Context. EX Lupi is a young, accreting M0 star and the prototype of EXor variable stars. Its spectrum is very rich in emission lines, including many metallic lines with narrow and broad components. The presence of a close companion has also been proposed, based on radial velocity signatures. Aims: We use the metallic emission lines to study the accretion structures and to test the companion hypothesis. Methods: We analyse 54 spectra obtained during five years of quiescence time. We study the line profile variability and the radial velocity of the narrow and broad metallic emission lines. We use the velocity signatures of different species with various excitation conditions and their time dependency to track the dynamics associated with accretion. Results: We observe periodic velocity variations in the broad and the narrow line components, consistent with rotational modulation. The modulation is stronger for lines with higher excitation potentials (e.g. He II), which are likely produced in a confined area very close to the accretion shock. Conclusions: We propose that the narrow line components are produced in the post-shock region, while the broad components originate in the more extended, pre-shock material in the accretion column. All the emission lines suffer velocity modulation due to the rotation of the star. The broad components are responsible for the line-dependent veiling observed in EX Lupi. We demonstrate that a rotationally modulated line-dependent veiling can explain the radial velocity signature of the photospheric absorption lines, making the close-in companion hypothesis unnecessary. The accretion structure is locked to the star and very stable during the five years of observations. Not all stars with similar spectral types and accretion rates show the same metallic emission lines, which could be related to differences in temperature and density in their accretion structure(s). The contamination of photospheric signatures by accretion

  18. Study of Thermonuclear Alfven Instabilities in Next Step Burning Plasma Experiments

    SciTech Connect

    N.N. Gorelenkov; H.L. Berk; R. Budny; C.Z. Cheng; G.-Y. Fu; W.W. Heidbrink; G. Kramer; D. Meade; and R. Nazikian

    2002-07-02

    A study is presented for the stability of alpha-particle driven shear Alfven Eigenmodes (AE) for the normal parameters of the three major burning plasma proposals, ITER (International Thermonuclear Experimental Reactor), FIRE (Fusion Ignition Research Experiment), and IGNITOR (Ignited Torus). A study of the JET (Joint European Torus) plasma, where fusion alphas were generated in tritium experiments, is also included to attempt experimental validation of the numerical predictions. An analytic assessment of Toroidal AE (TAE) stability is first presented, where the alpha particle beta due to the fusion reaction rate and electron drag is simply and accurately estimated in 7-20 keV plasma temperature regime. In this assessment the hot particle drive is balanced against ion-Landau damping of the background deuterons and electron collision effects and stability boundaries are determined. Then two numerical studies of AE instability are presented. In one the High-n stability code HINST is used . This code is capable of predicting instabilities of low and moderately high frequency Alfven modes. HINST computes the non-perturbative solution of the Alfven eigenmodes including effects of ion finite Larmor radius, orbit width, trapped electrons etc. The stability calculations are repeated using the global code NOVAK. We show that for these tokamaks the spectrum of the least stable AE modes are TAE that appear at medium-/high-n numbers. In HINST TAEs are locally unstable due to the alphas pressure gradient in all the devices under the consideration except IGNITOR. However, NOVAK calculations show that the global mode structure enhances the damping mechanisms and produces stability in all configurations considered here. A serious question remains whether the perturbation theory used in NOVAK overestimates the stability predictions, so that it is premature to conclude that the nominal operation of all three proposals are stable to AEs. In addition NBI ions produce a strong

  19. High luminosity, slow ejecta and persistent carbon lines: SN 2009dc challenges thermonuclear explosion scenarios

    NASA Astrophysics Data System (ADS)

    Taubenberger, S.; Benetti, S.; Childress, M.; Pakmor, R.; Hachinger, S.; Mazzali, P. A.; Stanishev, V.; Elias-Rosa, N.; Agnoletto, I.; Bufano, F.; Ergon, M.; Harutyunyan, A.; Inserra, C.; Kankare, E.; Kromer, M.; Navasardyan, H.; Nicolas, J.; Pastorello, A.; Prosperi, E.; Salgado, F.; Sollerman, J.; Stritzinger, M.; Turatto, M.; Valenti, S.; Hillebrandt, W.

    2011-04-01

    Extended optical and near-IR observations reveal that SN 2009dc shares a number of similarities with normal Type Ia supernovae (SNe Ia), but is clearly overluminous, with a (pseudo-bolometric) peak luminosity of log (L) = 43.47 (erg s-1). Its light curves decline slowly over half a year after maximum light [Δm15(B)true= 0.71], and the early-time near-IR light curves show secondary maxima, although the minima between the first and the second peaks are not very pronounced. The bluer bands exhibit an enhanced fading after ˜200 d, which might be caused by dust formation or an unexpectedly early IR catastrophe. The spectra of SN 2009dc are dominated by intermediate-mass elements and unburned material at early times, and by iron-group elements at late phases. Strong C II lines are present until ˜2 weeks past maximum, which is unprecedented in thermonuclear SNe. The ejecta velocities are significantly lower than in normal and even subluminous SNe Ia. No signatures of interaction with a circumstellar medium (CSM) are found in the spectra. Assuming that the light curves are powered by radioactive decay, analytic modelling suggests that SN 2009dc produced ˜1.8 M⊙ of 56Ni assuming the smallest possible rise time of 22 d. Together with a derived total ejecta mass of ˜2.8 M⊙, this confirms that SN 2009dc is a member of the class of possible super-Chandrasekhar-mass SNe Ia similar to SNe 2003fg, 2006gz and 2007if. A study of the hosts of SN 2009dc and other superluminous SNe Ia reveals a tendency of these SNe to explode in low-mass galaxies. A low metallicity of the progenitor may therefore be an important prerequisite for producing superluminous SNe Ia. We discuss a number of possible explosion scenarios, ranging from super-Chandrasekhar-mass white-dwarf progenitors over dynamical white-dwarf mergers and Type I? SNe to a core-collapse origin of the explosion. None of the models seems capable of explaining all properties of SN 2009dc, so that the true nature of this SN

  20. The microRNA miR-235 couples blast-cell quiescence to the nutritional state.

    PubMed

    Kasuga, Hidefumi; Fukuyama, Masamitsu; Kitazawa, Aya; Kontani, Kenji; Katada, Toshiaki

    2013-05-23

    The coordination of stem- and blast-cell behaviours, such as self-renewal, differentiation and quiescence, with physiological changes underlies growth, regeneration and tissue homeostasis. Germline stem and somatic blast cells in newly hatched Caenorhabditis elegans larvae can suspend postembryonic development, which consists of diverse cellular events such as migration, proliferation and differentiation, until the nutritional state becomes favourable (termed L1 diapause). Although previous studies showed that the insulin/insulin-like growth factor (IGF) signalling (IIS) pathway regulates this developmental quiescence, the detailed mechanism by which the IIS pathway enables these multipotent cells to respond to nutrient availability is unknown. Here we show in C. elegans that the microRNA (miRNA) miR-235, a sole orthologue of mammalian miR-92 from the oncogenic miR-17-92 cluster, acts in the hypodermis and glial cells to arrest postembryonic developmental events in both neuroblasts and mesoblasts. Expression of mir-235 persists during L1 diapause, and decreases upon feeding in a manner dependent on the IIS pathway. Upregulation of one of the miR-235 targets, nhr-91, which encodes an orthologue of mammalian germ cell nuclear factor, is responsible for defects caused by loss of the miRNA. Our findings establish a novel role of a miR-92 orthologue in coupling blast-cell behaviours to the nutritional state.

  1. Heterochromatin compaction is regulated by Suv4-20h1 to maintains skeletal muscle stem cells quiescence

    PubMed Central

    Machado, Léo

    2016-01-01

    In this report, Boonsanay and colleagues describe a novel mechanism of maintenance of skeletal muscle stem cells [also known as satellite cells (SCs)] quiescence via the di-methyltransferase Suv4-20h1, regulator of heterochromatin formation. Conditional ablation of Suv4-20h1 in SCs leads notably to the loss of the histone modification H4K20me2 on the distal regulatory element of Myod combined with a relocation of the Myod locus toward a central position in the nucleus. This switch in nuclear compartment is correlated with decreased facultative H3K27me3 associated heterochromatin, and an increase in spontaneously activated MYOD-expressing SCs in homeostatic muscles. Consequently, Suv4-20h1 knock-out SCs demonstrate compromised stem cell potential, as they fail to efficiently self-renew and replenish the SC pool upon muscle injury. Strikingly, restoring MYOD expression alone rescues the levels of facultative chromatin and reverses the loss-of-quiescence phenotype. PMID:27488816

  2. A Comparative Far UV Spectroscopic Study of the Dwarf Novae VW Vul and X Leo During Quiescence

    NASA Astrophysics Data System (ADS)

    Henry, C. K.; Sion, E. M.

    2000-12-01

    VW Vulpecula and X Leo are two U Geminorum type dwarf novae, the latter with a newly found orbital period (0.16870+/-0.00007 days). The inclination angle of VW Vul is known to be 44+/-12 deg, the mass of the white dwarf is 0.24+/-0.06 Msun, a secondary mass of 0.14+/-0.01 Msun and the system appears to have an outburst period of 14-24 days (Ritter & Kolb 2000). X Leo has nearly the same orbital period, outburst recurrence time and outburst amplitude but more uncertain orbital parameters. We have carried out an IUE archival comparative study of the two systems. We have applied the Massa-Fitzpatrick (2000) flux calibration correction to the archival IUE NEWSIPS SWP spectra of these two systems, obtained during dwarf nova quiescence. We have carried out high gravity model atmosphere using the codes TLUSTY195, SYNSPEC42, ROTIN and accretion disk synthetic spectra from the grid of Wade and Hubeny (1998). We have determined the physical properties of the white dwarf accreters, including temperature, gravity, chemical abundances estimates, and the accretion rate during quiescence. We discuss our results in the context of the overall picture of accretion physics in dwarf novae and the effects of accretion on the white dwarf. This research was supported in part by NSF grant AST 99-01955, NASA ADP grant NAG5-8388 and by summer research funding from the NASA- Delaware Space Grant Colleges Consortium.

  3. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

    PubMed Central

    Goldstein, Jill; Fletcher, Sean; Roth, Eve; Wu, Christine; Chun, Andrew; Horsley, Valerie

    2014-01-01

    In most tissues, the prevailing view is that stem cell (SC) niches are generated by signals from within the nearby tissue environment. Here, we define genetic changes altered in hair follicle (HF) SCs in mice treated with a potent SC activator, cyclosporine A (CSA), which inhibits the phosphatase calcineurin (CN) and the activity of the transcription factor nuclear factor of activated T cells c1 (Nfatc1). We show that CN/Nfatc1 regulates expression of prolactin receptor (Prlr) and that canonical activation of Prlr and its downstream signaling via Jak/Stat5 drives quiescence of HF SCs during pregnancy and lactation, when serum prolactin (Prl) levels are highly elevated. Using Prl injections and genetic/pharmacological loss-of-function experiments in mice, we show that Prl signaling stalls follicular SC activation through its activity in the skin epithelium. Our findings define a unique CN–Nfatc1–Prlr–Stat5 molecular circuitry that promotes persistent SC quiescence in the skin. PMID:24732379

  4. Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production

    PubMed Central

    Gillespie, Zoe E; MacKay, Kimberly; Sander, Michelle; Trost, Brett; Dawicki, Wojciech; Wickramarathna, Aruna; Gordon, John; Eramian, Mark; Kill, Ian R; Bridger, Joanna M; Kusalik, Anthony; Mitchell, Jennifer A; Eskiw, Christopher H

    2015-01-01

    Rapamycin is a well-known inhibitor of the Target of Rapamycin (TOR) signaling cascade; however, the impact of this drug on global genome function and organization in normal primary cells is poorly understood. To explore this impact, we treated primary human foreskin fibroblasts with rapamycin and observed a decrease in cell proliferation without causing cell death. Upon rapamycin treatment chromosomes 18 and 10 were repositioned to a location similar to that of fibroblasts induced into quiescence by serum reduction. Although similar changes in positioning occurred, comparative transcriptome analyses demonstrated significant divergence in gene expression patterns between rapamycin-treated and quiescence-induced fibroblasts. Rapamycin treatment induced the upregulation of cytokine genes, including those from the Interleukin (IL)-6 signaling network, such as IL-8 and the Leukemia Inhibitory Factor (LIF), while quiescent fibroblasts demonstrated up-regulation of genes involved in the complement and coagulation cascade. In addition, genes significantly up-regulated by rapamycin treatment demonstrated increased promoter occupancy of the transcription factor Signal Transducer and Activator of Transcription 5A/B (STAT5A/B). In summary, we demonstrated that the treatment of fibroblasts with rapamycin decreased proliferation, caused chromosome territory repositioning and induced STAT5A/B-mediated changes in gene expression enriched for cytokines. PMID:26652669

  5. Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy

    PubMed Central

    An, Wei; Nadeau, Scott A.; Mohapatra, Bhopal C.; Feng, Dan; Zutshi, Neha; Storck, Matthew D.; Arya, Priyanka; Talmadge, James E.; Meza, Jane L.; Band, Vimla; Band, Hamid

    2015-01-01

    Cbl and Cbl-b are tyrosine kinase-directed RING finger type ubiquitin ligases (E3s) that negatively regulate cellular activation pathways. E3 activity-disrupting human Cbl mutations are associated with myeloproliferative disorders (MPD) that are reproduced in mice with Cbl RING finger mutant knock-in or hematopoietic Cbl and Cbl-b double knockout. However, the role of Cbl proteins in hematopoietic stem cell (HSC) homeostasis, especially in the context of MPD is unclear. Here we demonstrate that HSC expansion and MPD development upon combined Cbl and Cbl-b deletion are dependent on HSCs. Cell cycle analysis demonstrated that DKO HSCs exhibit reduced quiescence associated with compromised reconstitution ability and propensity to undergo exhaustion. We show that sustained c-Kit and FLT3 signaling in DKO HSCs promotes loss of colony-forming potential, and c-Kit or FLT3 inhibition in vitro protects HSCs from exhaustion. In vivo, treatment with 5-fluorouracil hastens DKO HSC exhaustion and protects mice from death due to MPD. Our data reveal a novel and leukemia therapy-relevant role of Cbl and Cbl-b in the maintenance of HSC quiescence and protection against exhaustion, through negative regulation of tyrosine kinase-coupled receptor signaling. PMID:25871390

  6. Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.

    PubMed

    An, Wei; Nadeau, Scott A; Mohapatra, Bhopal C; Feng, Dan; Zutshi, Neha; Storck, Matthew D; Arya, Priyanka; Talmadge, James E; Meza, Jane L; Band, Vimla; Band, Hamid

    2015-04-30

    Cbl and Cbl-b are tyrosine kinase-directed RING finger type ubiquitin ligases (E3s) that negatively regulate cellular activation pathways. E3 activity-disrupting human Cbl mutations are associated with myeloproliferative disorders (MPD) that are reproduced in mice with Cbl RING finger mutant knock-in or hematopoietic Cbl and Cbl-b double knockout. However, the role of Cbl proteins in hematopoietic stem cell (HSC) homeostasis, especially in the context of MPD is unclear. Here we demonstrate that HSC expansion and MPD development upon combined Cbl and Cbl-b deletion are dependent on HSCs. Cell cycle analysis demonstrated that DKO HSCs exhibit reduced quiescence associated with compromised reconstitution ability and propensity to undergo exhaustion. We show that sustained c-Kit and FLT3 signaling in DKO HSCs promotes loss of colony-forming potential, and c-Kit or FLT3 inhibition in vitro protects HSCs from exhaustion. In vivo, treatment with 5-fluorouracil hastens DKO HSC exhaustion and protects mice from death due to MPD. Our data reveal a novel and leukemia therapy-relevant role of Cbl and Cbl-b in the maintenance of HSC quiescence and protection against exhaustion, through negative regulation of tyrosine kinase-coupled receptor signaling.

  7. Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

    PubMed Central

    Bersenev, Alexey; Wu, Chao; Balcerek, Joanna; Tong, Wei

    2008-01-01

    In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mpl, or Mpl), controls HSC homeostasis and self-renewal. Under steady-state conditions, mice lacking the inhibitory adaptor protein Lnk harbor an expanded HSC pool with enhanced self-renewal. We found that HSCs from Lnk–/– mice have an increased quiescent fraction, decelerated cell cycle kinetics, and enhanced resistance to repeat treatments with cytoablative 5-fluorouracil in vivo compared with WT HSCs. We further provide genetic evidence demonstrating that Lnk controls HSC quiescence and self-renewal, predominantly through Mpl. Consistent with this observation, Lnk–/– HSCs displayed potentiated activation of JAK2 specifically in response to TPO. Biochemical experiments revealed that Lnk directly binds to phosphorylated tyrosine residues in JAK2 following TPO stimulation. Of note, the JAK2 V617F mutant, found at high frequencies in myeloproliferative diseases, retains the ability to bind Lnk. Therefore, we identified Lnk as a physiological negative regulator of JAK2 in stem cells and TPO/Mpl/JAK2/Lnk as a major regulatory pathway in controlling stem cell self-renewal and quiescence. PMID:18618018

  8. Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum.

    PubMed

    Dai, Jian; Miller, Matthew A; Everetts, Nicholas J; Wang, Xia; Li, Peng; Li, Ye; Xu, Jian-Hua; Yao, Guang

    2017-01-13

    The medical mushroom Ganoderma lucidum has long been used in traditional Chinese medicine and shown effective in the treatment of many diseases including cancer. Here we studied the cytotoxic effects of two natural compounds purified from Ganoderma lucidum, ergosterol peroxide and ganodermanondiol. We found that these two compounds exhibited cytotoxicity not only against fast proliferating cells, but on quiescent, slow-cycling cells. Using a fibroblast cell-quiescence model, we found that the cytotoxicity on quiescent cells was due to induced apoptosis, and was associated with a shallower quiescent state in compound-treated cells, resultant from the increased basal activity of an Rb-E2F bistable switch that controls quiescence exit. Accordingly, we showed that quiescent breast cancer cells (MCF7), compared to its non-transformed counterpart (MCF10A), were preferentially killed by ergosterol peroxide and ganodermanondiol treatment presumably due to their already less stable quiescent state. The cytotoxic effect of natural Ganoderma lucidum compounds against quiescent cells, preferentially on quiescent cancer cells vs. non-cancer cells, may help future antitumor development against the slow-cycling cancer cell subpopulations including cancer stem and progenitor cells.

  9. On the implementation of a chain nuclear reaction of thermonuclear fusion on the basis of the p+11B process

    NASA Astrophysics Data System (ADS)

    Belyaev, V. S.; Krainov, V. P.; Zagreev, B. V.; Matafonov, A. P.

    2015-07-01

    Various theoretical and experimental schemes for implementing a thermonuclear reactor on the basis of the p+11B reaction are considered. They include beam collisions, fusion in degenerate plasmas, ignition upon plasma acceleration by ponderomotive forces, and the irradiation of a solid-state target from 11B with a proton beam under conditions of a Coulomb explosion of hydrogen microdrops. The possibility of employing ultra-short high-intensity laser pulses to initiate the p+11B reaction under conditions far from thermodynamic equilibrium is discussed. This and some other weakly radioactive thermonuclear reactions are promising owing to their ecological cleanness—there are virtually no neutrons among fusion products. Nuclear reactions that follow the p+11B reaction may generate high-energy protons, sustaining a chain reaction, and this is an advantage of the p+11B option. The approach used also makes it possible to study nuclear reactions under conditions close to those in the early Universe or in the interior of stars.

  10. Rotigotine's effect on PLM-associated blood pressure elevations in restless legs syndrome

    PubMed Central

    Cassel, Werner; Benes, Heike; Kesper, Karl; Rye, David; Sica, Domenic; Winkelman, John W.; Bauer, Lars; Grieger, Frank; Joeres, Lars; Moran, Kimberly; Schollmayer, Erwin; Whitesides, John; Carney, Hannah C.; Walters, Arthur S.; Oertel, Wolfgang; Trenkwalder, Claudia

    2016-01-01

    Objective: This double-blind, placebo-controlled, interventional trial was conducted to investigate the effects of rotigotine patch on periodic limb movement (PLM)–associated nocturnal systolic blood pressure (SBP) elevations. Methods: Patients with moderate to severe restless legs syndrome (RLS) were randomized to rotigotine (optimal dose [1–3 mg/24 h]) or placebo. Continuous beat-to-beat blood pressure (BP) assessments were performed during polysomnography at baseline and at the end of 4-week maintenance. Primary outcome was change in number of PLM-associated SBP elevations (defined as slope of linear regression ≥2.5 mm Hg/beat-to-beat interval over 5 consecutive heartbeats [≥10 mm Hg]). Additional outcomes were total SBP elevations, PLM-associated and total diastolic BP (DBP) elevations, periodic limb movements index (PLMI), and PLM in sleep arousal index (PLMSAI). Results: Of 81 randomized patients, 66 (37 rotigotine, 29 placebo) were included in efficacy assessments. PLM-associated SBP elevations were significantly reduced with rotigotine vs placebo (least squares mean treatment difference [95% confidence interval (CI)] −160.34 [−213.23 to −107.45]; p < 0.0001). Rotigotine-treated patients also had greater reduction vs placebo in total SBP elevations (−161.13 [−264.47 to −57.79]; p = 0.0028), PLM-associated elevations (−88.45 [−126.12 to −50.78]; p < 0.0001), and total DBP elevations (−93.81 [−168.45 to −19.16]; p = 0.0146), PLMI (−32.77 [−44.73 to −20.80]; p < 0.0001), and PLMSAI (−7.10 [−11.93 to −2.26]; p = 0.0047). Adverse events included nausea (rotigotine 23%; placebo 8%), headache (18% each), nasopharyngitis (18%; 8%), and fatigue (13%; 15%). Conclusions: Further investigation is required to determine whether reductions in nocturnal BP elevations observed with rotigotine might modify cardiovascular risk. Classification of evidence: This study provides Class I evidence that for patients with moderate to severe

  11. Cotopaxi volcano's unrest and eruptive activity in 2015: mild awakening after 73 years of quiescence

    NASA Astrophysics Data System (ADS)

    Hidalgo, Silvana; Bernard, Benjamin; Battaglia, Jean; Gaunt, Elizabeth; Barrington, Charlotte; Andrade, Daniel; Ramón, Patricio; Arellano, Santiago; Yepes, Hugo; Proaño, Antonio; Almeida, Stefanie; Sierra, Daniel; Dinger, Florian; Kelly, Peter; Parra, René; Bobrowski, Nicole; Galle, Bo; Almeida, Marco; Mothes, Patricia; Alvarado, Alexandra

    2016-04-01

    Cotopaxi volcano (5,897 m) is located 50 km south of Quito, the capital of Ecuador. The most dangerous hazards of this volcano are the devastating lahars that can be generated by the melting of its ice cap during pyroclastic flow-forming eruptions. The first seismic station was installed in 1976. Cotopaxi has been monitored by the Instituto Geofísico (Escuela Politécnica Nacional) since 1983. Presently the monitoring network is comprised of 11 broadband and 5 short period seismometers, 4 scanning DOAS, 1 infrared and 5 visible cameras, 7 DGPS, 5 tiltmeters, 11 AFM (lahar detectors) and a network of ashmeters. Due to the recent unrest, the monitoring of the volcano has been complemented by campaign airborne Multi-GAS and thermal IR measurements and ground-based mobile DOAS and stationary solar FTIR. After 73 years of quiescence, the first sign of unrest was a progressive increase in the amplitude of transient seismic events in April 2015. Since May 20, an increase in SO2 emissions from ˜500 t/d to ˜3 kt/day was detected followed by the appearance of seismic tremor on June 4. Both SO2 emissions of up to 5 kt/day and seismic tremor were observed until August 14 when a swarm of volcano-tectonic earthquakes preceded the first phreatic explosions. These explosions produced ash and gas columns reaching up to 9 km above the crater. The ash fall produced by the opening phase covered over 500 km2 with a submillimetric deposit corresponding to a mass of 1.65E+8 kg (VEI 1). During this period of explosions, SO2 emission rates up to 24 kt/day were observed, the highest thus far. The ash was dominantly hydrothermally altered and oxidized lithic fragments, hydrothermal minerals (alunite, gypsum), free crystals of plagioclase and pyroxenes, and little juvenile material. Unrest continued after August 14, with three episodes of ash emission. However, the intensity of ash fallout, average seismic amplitude, and SO2 emissions during each successive episode progressively decreased

  12. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis.

    PubMed

    Lee, Jayhun; Kang, Sangjo; Lilja, Karin C; Colletier, Keegan J; Scheitz, Cornelia Johanna Franziska; Zhang, Ying V; Tumbar, Tudorita

    2016-04-15

    Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T-cell progenitors. Here we find histone H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells (HFSCs) during G0 quiescence. The level of marks over specific gene promoters did not correlate to mRNA level changes in quiescent HFSCs. Skin hypomethylation during quiescence was necessary for subsequent progression of hair homeostasis (cycle). Inhibiting BMP signal, a known HFSC anti-proliferative factor, elevated HFSC methylation in vivo during quiescence prior to proliferation onset. Furthermore, removal of proliferation factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured skin epithelial cells. We conclude that signalling couples hair follicle stem cell quiescence with reduced H3 K4/K9/K27me3 levels for proper tissue homeostasis.

  13. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis

    PubMed Central

    Lee, Jayhun; Kang, Sangjo; Lilja, Karin C.; Colletier, Keegan J.; Scheitz, Cornelia Johanna Franziska; Zhang, Ying V.; Tumbar, Tudorita

    2016-01-01

    Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T-cell progenitors. Here we find histone H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells (HFSCs) during G0 quiescence. The level of marks over specific gene promoters did not correlate to mRNA level changes in quiescent HFSCs. Skin hypomethylation during quiescence was necessary for subsequent progression of hair homeostasis (cycle). Inhibiting BMP signal, a known HFSC anti-proliferative factor, elevated HFSC methylation in vivo during quiescence prior to proliferation onset. Furthermore, removal of proliferation factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured skin epithelial cells. We conclude that signalling couples hair follicle stem cell quiescence with reduced H3 K4/K9/K27me3 levels for proper tissue homeostasis. PMID:27080563

  14. Laser initiated thermonuclear reactions. January 1970-May 1981 (citations from the Searchable Physics Information Notices data base). Report for January 1970-May 1981

    SciTech Connect

    Not Available

    1981-05-01

    The use of lasers for the initiation of thermonuclear reactions is considered. Emphasis is placed on the initiator (primarily a carbon dioxide laser) and the properties of the target material. The latter is usually in the form of spherical glass particles. Methods for the confinement of the plasma are also discussed. (Contains 105 citations fully indexed and including a title list.)

  15. XMM-Newton Observations of the Be/X-Ray Transient A0538-66 in Quiescence

    NASA Astrophysics Data System (ADS)

    Kretschmar, P.; Wilms, J.; Staubert, R.; Kreykenbohm, I.; Heindl, W. A.

    2004-10-01

    We present XMM-Newton observations of the recurrent Be/X-ray transient A0538-66, situated in the Large Mag- ellanic Cloud, in the quiescent state. Despite a very low luminosity state of (5-8)×1033 ergs/s in the range 0.3- 10 keV, the source is clearly detected up to ˜8 keV. and can be fitted using either a power law with pho- ton index α=1.9±0.3 or a bremsstrahlung spectrum with kT=3.9+3.9 -1.7 keV. The spectral analysis confirms that the off-state spectrum is hard without requiring any soft com- ponent, contrary to the majority of neutron stars observed in quiescence up to now. Key words: A0538-66; XMM-Newton; quiescent emis- sion.

  16. De-submergence responses of antioxidative defense systems in two wetland plants having escape and quiescence strategies.

    PubMed

    Luo, Fang-Li; Thiele, Björn; Janzik, Ingar; Zeng, Bo; Schurr, Ulrich; Matsubara, Shizue

    2012-11-15

    Fast recovery after de-submergence requires efficient protection against oxidative injuries. We investigated whether de-submergence responses of antioxidant systems differ in two wetland plants, Alternanthera philoxeroides and Hemarthria altissima, characterized by 'escape' and 'quiescence' strategies of flood tolerance, respectively. The antioxidant capacity was assessed in the two species during 10d of recovery following 20d of complete submergence (low light+low O(2)) or severe shading (low light+ambient O(2)). The activities of superoxide dismutase and catalase were measured in leaf and root tissues, along with the concentrations of reduced ascorbate, malondialdehyde, and acetaldehyde. In addition, formation of superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) was detected in leaves by chemical staining. Following de-submergence, plants of A. philoxeroides showed a transient burst of acetaldehyde, while the concentration of acetaldehyde increased slowly and stayed high in leaves of H. altissima. In leaves of A. philoxeroides, the variations in O(2)(-) and H(2)O(2) correlated with the levels of light and O(2), respectively, whereas neither of the two reactive oxygen species was detected in H. altissima. For A. philoxeroides, the antioxidant capacities changed mainly in leaves during the recovery. For H. altissima, changes in reduced ascorbate were found in leaves and those of antioxidant enzyme activities in roots. De-submergence caused some lipid peroxidation in leaves of both species. We conclude that de-submergence responses of the detoxification systems differ between A. philoxeroides and H. altissima, especially in leaves. Dynamic changes were found in A. philoxeroides (having the escape strategy), as opposed to little or slow changes in H. altissima (having the quiescence strategy). Whereas the antioxidant capacities are often strongly influenced by light environments, the toxic compounds and lipid peroxidation indicate harmful effects of changing O(2

  17. ON THE EFFECT OF EXPLOSIVE THERMONUCLEAR BURNING ON THE ACCRETED ENVELOPES OF WHITE DWARFS IN CATACLYSMIC VARIABLES

    SciTech Connect

    Sion, Edward M.; Sparks, Warren E-mail: warrensparks@comcast.net

    2014-11-20

    The detection of heavy elements at suprasolar abundances in the atmospheres of some accreting white dwarfs in cataclysmic variables (CVs), coupled with the high temperatures needed to produce these elements, requires explosive thermonuclear burning. The central temperatures of any formerly more massive secondary stars in CVs undergoing hydrostatic CNO burning are far too low to produce these elements. Evidence is presented that at least some CVs contain donor secondaries that have been contaminated by white dwarf remnant burning during the common envelope phase and are transferring this material back to the white dwarf. This scenario does not exclude the channel in which formerly more massive donor stars underwent CNO processing in systems with thermal timescale mass transfer. Implications for the progenitors of CVs are discussed and a new scenario for the white dwarf's accretion-nova-outburst is given.

  18. Transition from Beam-Target to Thermonuclear Fusion in High-Current Deuterium Z-Pinch Simulations

    NASA Astrophysics Data System (ADS)

    Offermann, Dustin; Welch, Dale; Rose, Dave; Thoma, Carsten; Clark, Robert; Mostrom, Chris; Schmidt, Andrea; Link, Anthony

    2016-10-01

    Fusion yields from dense, Z-pinch plasmas are known to scale with the drive current, which is favorable for many potential applications. Decades of experimental studies, however, show an unexplained drop in yield for currents above a few mega-ampere (MA). In this work, simulations of DD Z-Pinch plasmas have been performed in 1D and 2D for a constant pinch time and initial radius using the code LSP, and observations of a shift in scaling are presented. The results show that yields below 3 MA are enhanced relative to pure thermonuclear scaling by beamlike particles accelerated in the Rayleigh-Taylor induced electric fields, while yields above 3 MA are reduced because of energy lost by the instability and the inability of the beamlike ions to enter the pinch region. This research was developed with funding from the Defense Advanced Research Projects Agency (DARPA).

  19. Gabapentin treatment in clozapine-induced restless legs syndrome: two cases and a review of the literature

    PubMed Central

    Kumar, Vijaya; Venkatasubramanian, Ganesan

    2016-01-01

    Restless legs syndrome (RLS) is a neuro-sensorimotor disorder affecting 2–4% of adults. It is characterized by intense urges to move the legs, associated with unpleasant sensory disturbances in the legs occurring at rest and manifests mostly in the evening and night, relieved by movement. Diagnosis is primarily based on clinical presentation and the consensus criteria for the diagnosis have been established. Antipsychotics, the dopamine antagonists, have been reported to induce RLS. Dopamine agonists, the effective first-line treatment of RLS, carry the risk of inducing or worsening psychosis. Many nondopaminergic agents including antiepileptic medications have also been used in the treatment of primary RLS. In this report we describe clozapine-induced RLS in two patients with schizophrenia and its successful treatment with gabapentin, a nondopaminergic agent. In addition, we have reviewed the available literature on clozapine-induced RLS and its management. PMID:28101323

  20. Prevalence and Characteristics of Periodic Limb Movements during Sleep in Korean Adult Patients with Restless Legs Syndrome

    PubMed Central

    Shin, Jung-won; Koo, Yong Seo; Lee, Byeong Uk; Shin, Won Chul; Lee, Sang Kun; Cho, Yong Won; Jung, Ki-Young

    2016-01-01

    Study Objectives: The aim of this study was to investigate the prevalence and characteristics of periodic limb movements during sleep (PLMS) in Korean patients with restless legs syndrome (RLS). Methods: Unmedicated adult patients with idiopathic RLS (n = 354) who underwent polysomnography at three major sleep centers in tertiary hospitals were included. Characteristics of PLMS in RLS were analyzed using the time structure of polysomnographically recorded leg movements and periodicity indices (PIs). RLS severity and subjective sleep quality were assessed. Results: Out of 354 patients with idiopathic RLS (mean age: 52.9 ± 12.0 years), 150 patients (42.3%) had RLS with a PLMS index greater than 15 events/h, and 204 (57.9%) had a PLMS index greater than 5 events/h. The distribution of inter-LM intervals was bimodal, and high PIs (0.86 ± 0.10) were observed in patients with RLS and PLMS (PLMS index > 15 events/h). The PLMS index was positively correlated with age (r = 0.228; p < 0.001), the periodic limb movements in wakefulness index (r = 0.455, p < 0.001) and arousal index (r = 0.174, p = 0.014), but not with RLS severity and parameters of sleep quality. In multivariate analysis, age and male gender were independently associated with PLMS > 15 events/h. Conclusions: The prevalence of PLMS in Korean patients with RLS was lower than that observed in Western countries, but the characteristics of PLMS were not different. Ethnic differences and/or different genetic backgrounds may contribute to the varying prevalence of PLMS in RLS. Citation: Shin JW, Koo YS, Lee BU, Shin WC, Lee SK, Cho YW, Jung KY. Prevalence and characteristics of periodic limb movements during sleep in Korean adult patients with restless legs syndrome. J Clin Sleep Med 2016;12(8):1089–1097. PMID:27306390

  1. Pramipexole: new use for an old drug – the potential use of pramipexole in the treatment of restless legs syndrome

    PubMed Central

    Benbir, Gulcin; Guilleminault, Christian

    2006-01-01

    Restless legs syndrome (RLS) is characterized by paraesthesias–dysesthesias and motor restlessness worsening at rest–in the evening, with at least temporary relief by activity. Its etiology is unknown, though it could be secondary to various conditions. It is well known, however, that dopamine plays a crucial role in the pathophysiology of RLS, as dopaminergic agonists achieve marked improvement. Pramipexole is a nonergoline compound with selectivity for D3 dopamine receptors. This drug is very effective in the treatment of idiopathic and secondary RLS and in treatment-resistant patients, as shown by double-blind, placebo-controlled studies in adults. In children, studies are much more limited, and RLS is often misdiagnosed as “growing pain” or attention deficit hyperactivity disorder. Pramipexole has been successful in open studies, eliminating clinical symptoms. This medication has the advantage of being free of the frequently encountered problems seen with ergot derivatives. The side-effects are limited, particularly at the dosages usually prescribed for RLS treatment: They are much lower than in Parkinson’s disease, and inappropriate sleepiness and sleep attacks, particularly while driving, or compulsive behavior have not been seen. Compared with the adverse reactions of levodopa, including tolerance, rebound, and augmentation phenomena in RLS, which led to usage of dopamine agonists as first line of treatment for RLS, pramipexole has had one of the best profiles. Augmentation can still be noted with the drug, but after longer usage time compared with many other dopamine agonists. Although excessive daytime sleepiness has been noted, sleep attacks have not been encountered in RLS patients treated with pramipexole. PMID:19412489

  2. Management of symptoms of Restless Legs Syndrome with use of a traction straight leg raise: a preliminary case series.

    PubMed

    Dinkins, Eric M; Stevens-Lapsley, Jennifer

    2013-08-01

    Restless Legs Syndrome (RLS) is estimated to affect 5-15 percent of the U.S. population. There are few studies investigating non-pharmacological treatments for RLS, such as physical therapy and/or peripheral neural mobilization. The traction straight leg raise (tSLR) technique is one such mobilization that may affect central and peripheral neural pathways and reduce RLS symptoms. The purpose of this study is to determine the effects of a tSLR on the symptoms associated with RLS. A cohort of fifteen people was enrolled. Thirteen subjects (11 female) between the ages of 32-64 completed the study. Subjects completed two questionnaires to quantify their severity of RLS before treatment was initiated and at the final session. These measures included: the Restless Legs Syndrome Rating Scale (RLSRS) 0-40, an RLS Ordinal Scale, and a Global Rating of Change (GROC) assessments (-7, 0, +7). Patients were treated with tSLR bilaterally for four total visits on days 1, 3, 8, and 15. Results indicated an RLSRS pre-treatment average of 24.8 (severe) and post-treatment average of 9.2 (mild), representing a 63% improvement from baseline (p < 0.05). Ten of 13 subjects reported a GROC of +4 or higher at the final session, indicating at least a moderate improvement in patient status from baseline. Our results indicate that following a series of tSLR treatments symptoms were reduced in individuals with idiopathic RLS. A prospective, randomized controlled trial is necessary to evaluate the potential for a tSLR to effectively manage idiopathic RLS symptoms.

  3. High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo.

    PubMed

    Yamada, Michiko; Tatsumi, Ryuichi; Yamanouchi, Keitaro; Hosoyama, Tohru; Shiratsuchi, Sei-ichi; Sato, Akiko; Mizunoya, Wataru; Ikeuchi, Yoshihide; Furuse, Mitsuhiro; Allen, Ronald E

    2010-03-01

    Skeletal muscle regeneration and work-induced hypertrophy rely on molecular events responsible for activation and quiescence of resident myogenic stem cells, satellite cells. Recent studies demonstrated that hepatocyte growth factor (HGF) triggers activation and entry into the cell cycle in response to mechanical perturbation, and that subsequent expression of myostatin may signal a return to cell quiescence. However, mechanisms responsible for coordinating expression of myostatin after an appropriate time lag following activation and proliferation are not clear. Here we address the possible role of HGF in quiescence through its concentration-dependent negative-feedback mechanism following satellite cell activation and proliferation. When activated/proliferating satellite cell cultures were treated for 24 h beginning 48-h postplating with 10-500 ng/ml HGF, the percentage of bromodeoxyuridine-incorporating cells decreased down to a baseline level comparable to 24-h control cultures in a HGF dose-dependent manner. The high level HGF treatment did not impair the cell viability and differentiation levels, and cells could be reactivated by lowering HGF concentrations to 2.5 ng/ml, a concentration that has been shown to optimally stimulate activation of satellite cells in culture. Coaddition of antimyostatin neutralizing antibody could prevent deactivation and abolish upregulation of cyclin-dependent kinase (Cdk) inhibitor p21. Myostatin mRNA expression was upregulated with high concentrations of HGF, as demonstrated by RT-PCR, and enhanced myostatin protein expression and secretion were revealed by Western blots of the cell lysates and conditioned media. These results indicate that HGF could induce satellite cell quiescence by stimulating myostatin expression. The HGF concentration required (over 10-50 ng/ml), however, is much higher than that for activation, which is initiated by rapid release of HGF from its extracellular association. Considering that HGF is produced

  4. “The Marshall Rosenbluth International Summer School – 2007: Plasma Thermonuclear Fusion and Plasma Astrophysics – 2007”

    SciTech Connect

    Stefan, Vladislav Alexander

    2007-10-01

    Contents: H. Berk: Frequency Sweeping Due to Phase Space Structure Formation in Plasmas M. Campbell : The Legacy of Marshall Rosenbluth in the Development of the Laser Fusion Program in the United States J. Candy: Gyrokinetic Simulations of Fusion Plasmas P. Diamond: The Legacy of Marshall Rosenbluth in Magnetic Confinement Theory G-Y. Fu: Nonlinear Hybrid Simulations of Multiple Energetic Particle Driven Alfven Modes in Toroidal Plasmas O. Gurcan: Theory of Intrinsic Rotation and Momentum Transport V. L. Jacobs: Kinetic and Spectral Descriptions for Atomic Processes in Astrophysical and Laboratory Plasmas C. F. Kennel: Marshall Rosenbluth and Roald Sagdeev in Trieste:The Birth of Modern Space Plasma N. A. Krall: The Contribution of Marshall Rosenbluth in the Development of Plasma Drift Wave and Universal Instability Theories C. S. Liu: The Legacy of Marshall Rosenbluth in Laser-Plasma Interaction Research N. Rostoker: Plasma Physics Research With Marshall Rosenbluth - My Teacher R. Z. Sagdeev: The Legacy of Marshall Rosenbluth in Plasma Physics V. Alexander Stefan A Note on the Rosenbluth Paper: Phys. Rev. Letters, 29, 565 (1972), and the Research in Parametric Plasma Theory Thereupon J. W. Van Dam: The Role of Marshall Rosenbluth in the Development of the Thermonuclear Fusion Program in the U.S.A. E. P. Velikhov: Problems in Plasma Astrophysics R. White: The Role of Marshall Rosenbluth in the Development of the Particle and MHD Interaction in Plasmas X. Xu: Edge Gyrokinetic Theory and Continuum Simulations Marshall Nicholas ROSENBLUTH (A Brief Biography) b. February 5,1927 - Albany, New York. d. September 28, 2003 - San Diego, California. M. N. Rosenbluth, a world-acclaimed scientist, is one of the ultimate authorities in plasma and thermonuclear fusion research, often indicated by the sobriquet the "Pope of Plasma Physics." His theoretical contributions have been central to the development of controlled thermonuclear fusion. In the 1950s his pioneering work in

  5. Accretion and Outflows in X-ray Binaries: What's Really Going on During X-ray Quiescence

    NASA Astrophysics Data System (ADS)

    MacDonald, Rachel K. D.; Bailyn, Charles D.; Buxton, Michelle

    2015-01-01

    X-ray binaries, consisting of a star and a stellar-mass black hole, are wonderful laboratories for studying accretion and outflows. They evolve on timescales quite accessible to us, unlike their supermassive cousins, and allow the possibility of gaining a deeper understanding of these two common astrophysical processes. Different wavelength regimes reveal different aspects of the systems: radio emission is largely generated by outflows and jets, X-ray emission by inner accretion flows, and optical/infrared (OIR) emission by the outer disk and companion star. The search for relationships between these different wavelengths is thus an area of active research, aiming to reveal deeper connections between accretion and outflows.Initial evidence for a strong, tight correlation between radio and X-ray emission has weakened as further observations and newly-discovered sources have been obtained. This has led to discussions of multiple tracks or clusters, or the possibility that no overall relation exists for the currently-known population of X-ray binaries. Our ability to distinguish among these options is hampered by a relative lack of observations at lower luminosities, and especially of truly X-ray quiescent (non-outbursting) systems. Although X-ray binaries spend the bulk of their existence in quiescence, few quiescent sources have been observed and multiple observations of individual sources are largely nonexistent. Here we discuss new observations of the lowest-luminosity quiescent X-ray binary, A0620-00, and the place this object occupies in investigations of the radio/X-ray plane. For the first time, we also incorporate simultaneous OIR data with the radio and X-ray data.In December 2013 we took simultaneous observations of A0620-00 in the X-ray (Chandra), the radio (EVLA), and the OIR (SMARTS 1.3m). These X-ray and radio data allowed us to investigate similarities among quiescent X-ray binaries, and changes over time for this individual object, in the radio

  6. Optical spectroscopy of EX Lupi during quiescence and outburst. Infall, wind, and dynamics in the accretion flow

    NASA Astrophysics Data System (ADS)

    Sicilia-Aguilar, A.; Kóspál, Á.; Setiawan, J.; Ábrahám, P.; Dullemond, C.; Eiroa, C.; Goto, M.; Henning, Th.; Juhász, A.

    2012-08-01

    Context. EX Lupi is the prototype of EXor variables. After 50 years of mild variability and smaller outbursts, the object again experienced a large outburst in 2008. Aims: We explore the accretion mechanisms in EX Lupi during its pre-outburst, outburst, and post-outburst phases. Methods: We analyze 10 high-resolution optical spectra of EX Lupi, taken before, during, and after the 2008 outburst. In both quiescence and outburst, the star presents many permitted emission lines. These include lines typical of accreting T Tauri stars, plus a large number of neutral and ionized metallic lines (mostly Fe I and Fe II). During the outburst, the number of emission lines increases to about a thousand, and their structure shows a narrow and a broad component (NC and BC). We study the structure of the BC, which is highly variable on short timescales (24-72 h). Results: An active chromosphere can explain the metallic lines in quiescence and the outburst NC. The dynamics of the BC line profiles suggest that these profiles originate in a hot, dense, non-axisymmetric, and non-uniform accretion column that suffers velocity variations along the line-of-sight on timescales of days. Assuming Keplerian rotation, the emitting region would be located at ~0.1-0.2 AU, which is consistent with the location of the inner disk rim, but the velocity profiles of the lines reveal a combination of rotation and infall. Line ratios of ions and neutrals can be reproduced assuming a temperature of T ~ 6500 K for electron densities of a few times 1012 cm-3 in the line-emitting region. The line profiles also indicate that there is an accretion-related inner disk wind. Conclusions: The data confirm that the 2008 outburst was an episode of increased accretion, albeit much stronger than previous EX Lupi and typical EXors outbursts. The line profiles are consistent with the infall/rotation of a non-axisymmetric structure that could be produced by clumpy accretion during the outburst phase. A strong inner

  7. The Effect of Atomoxetin Use in the Treatment of Attention-Deficit/Hyperactivity Disorder on the Symptoms of Restless Legs Syndrome: A Case Report.

    PubMed

    Baykal, Saliha; Karakurt, Melih Nuri

    2017-02-13

    Attention-deficit/hyperactivity disorder (ADHD) is frequently accompanied with sleep disorders such as obstructive sleep apnea, periodic limb movement disorder, restless legs syndrome (RLS), and circadian rhythm disorder. We have limited information about the effects of medical therapies used in the treatment of ADHD on RLS. This article discusses the effects of atomoxetine treatment on both disorders in a patient followed by diagnoses of ADHD and RLS.

  8. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group.

    PubMed

    Garcia-Borreguero, Diego; Kohnen, Ralf; Silber, Michael H; Winkelman, John W; Earley, Christopher J; Högl, Birgit; Manconi, Mauro; Montplaisir, Jacques; Inoue, Yuichi; Allen, Richard P

    2013-07-01

    A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) to develop evidence-based and consensus-based recommendations for the long-term pharmacologic treatment of restless legs syndrome/Willis-Ekbom disease (RLS/WED). The Task Force reviewed the results of all studies of RLS/WED treatments with durations of 6 months or longer presented at meetings over the past 2 years, posted on Web sites of pharmaceutical companies, or published in peer-reviewed journals, asking the questions, "What is the efficacy of this treatment in patients with RLS/WED?" and "What is the safety of this treatment in patients with RLS/WED?" The Task Force developed guidelines based on their review of 61 papers meeting inclusion criteria, and using a modified evidence-grading scheme. Pregabalin has been established as effective for up to 1 year in treating RLS/WED (Level A evidence). Pramipexole, ropinirole, and rotigotine have been established as effective for up to 6 months in treating RLS/WED (Level A). The following drugs have been established as probably effective (Level B) in treating RLS/WED for durations ranging from 1 to 5 years: gabapentin enacarbil, pramipexole, and ropinirole (1 year); levodopa (2 years); and rotigotine (5 years). Because of associated safety concerns, pergolide and cabergoline should not be used in the treatment of RLS/WED unless the benefits clearly outweigh the risks. Other pharmacologic therapies have insufficient evidence to support their long-term use in treating RLS/WED. The IRLSSG Task Force also developed consensus-based strategies for the prevention and treatment of complications (such as augmentation, loss of efficacy, excessive daytime sleepiness, and impulse control disorders) that may develop with the long-term pharmacologic treatment of RLS/WED. The use of either a dopamine-receptor agonist or α2δ calcium-channel ligand is recommended as the first-line treatment of RLS/WED for most patients, with the choice of

  9. SOAR observations of the high-viscosity accretion disc of the dwarf nova V4140 Sagitarii in quiescence and in outburst

    NASA Astrophysics Data System (ADS)

    Baptista, Raymundo; Borges, Bernardo W.; Oliveira, Alexandre S.

    2016-12-01

    We report the analysis of 22 B-band light curves of the dwarf nova V4140 Sgr obtained with SOAR Optical Imager (SOI)/SOAR during two nights along the decline of a superoutburst in 2006 September 12-24 and in quiescence over 50 d following the superoutburst. 3D eclipse mapping of the outburst light curves indicates that the accretion disc is elliptical (eccentricity e = 0.13) and that superhump maximum occurs when the mass donor star is aligned with the bulge of the elliptical disc. The accretion disc is geometrically thin both in outburst and in quiescence; it fills the primary Roche lobe in the outburst and shrinks to about half this size in quiescence. The stability of the eclipse shape, width and depth along quiescence and the derived disc surface brightness distribution indicate that the quiescent accretion disc is in a high-viscosity, steady-state. Flickering mapping of the quiescent data reveals that the low-frequency flickering arises from an azimuthally extended stream-disc impact region at disc rim and from the innermost disc region, whereas the high-frequency flickering originates in the accretion disc. Assuming the disc-related flickering to be caused by fluctuations in the energy dissipation rate induced by magnetohydrodynamic turbulence (Geertsema & Achterberg), we find that the quiescent disc viscosity parameter is large, α ≃ 0.2-0.4, at all radii. The high-viscosity quiescent disc and the inferred low disc temperatures in superoutburst are inconsistent with expectations of the disc-instability model, and lead to the conclusion that the outbursts of V4140 Sgr are powered by mass transfer bursts from its donor star.

  10. A fine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2/RIZ at a bivalent domain in the cyclin a gene.

    PubMed

    Cheedipudi, Sirisha; Puri, Deepika; Saleh, Amena; Gala, Hardik P; Rumman, Mohammed; Pillai, Malini S; Sreenivas, Prethish; Arora, Reety; Sellathurai, Jeeva; Schrøder, Henrik Daa; Mishra, Rakesh K; Dhawan, Jyotsna

    2015-07-27

    Adult stem cell quiescence is critical to ensure regeneration while minimizing tumorigenesis. Epigenetic regulation contributes to cell cycle control and differentiation, but few regulators of the chromatin state in quiescent cells are known. Here we report that the tumor suppressor PRDM2/RIZ, an H3K9 methyltransferase, is enriched in quiescent muscle stem cells in vivo and controls reversible quiescence in cultured myoblasts. We find that PRDM2 associates with >4400 promoters in G0 myoblasts, 55% of which are also marked with H3K9me2 and enriched for myogenic, cell cycle and developmental regulators. Knockdown of PRDM2 alters histone methylation at key promoters such as Myogenin and CyclinA2 (CCNA2), and subverts the quiescence program via global de-repression of myogenesis, and hyper-repression of the cell cycle. Further, PRDM2 acts upstream of the repressive PRC2 complex in G0. We identify a novel G0-specific bivalent chromatin domain in the CCNA2 locus. PRDM2 protein interacts with the PRC2 protein EZH2 and regulates its association with the bivalent domain in the CCNA2 gene. Our results suggest that induction of PRDM2 in G0 ensures that two antagonistic programs-myogenesis and the cell cycle-while stalled, are poised for reactivation. Together, these results indicate that epigenetic regulation by PRDM2 preserves key functions of the quiescent state, with implications for stem cell self-renewal.

  11. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.

    PubMed

    Lay, Kenneth; Kume, Tsutomu; Fuchs, Elaine

    2016-03-15

    Adult tissue stem cells (SCs) reside in niches, which orchestrate SC behavior. SCs are typically used sparingly and exist in quiescence unless activated for tissue growth. Whether parsimonious SC use is essential to conserve long-term tissue-regenerating potential during normal homeostasis remains poorly understood. Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (HFSCs). FOXC1-deficient HFSCs spend less time in quiescence, leading to markedly shortened resting periods between hair cycles. The enhanced hair cycling accelerates HFSC expenditure, and impacts hair regeneration in aging mice. Interestingly, although FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the older bulge is left unanchored. As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inner cell layer, is lost. We trace this mechanism first, to a marked increase in cell cycle-associated transcripts upon Foxc1 ablation, and second, to a downstream reduction in E-cadherin-mediated inter-SC adhesion. Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC-inhibitory factors are reduced, further lowering the threshold for HFSC activity. Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.

  12. The dual effects of root-cap exudates on nematodes: from quiescence in plant-parasitic nematodes to frenzy in entomopathogenic nematodes

    PubMed Central

    Hiltpold, Ivan; Jaffuel, Geoffrey; Turlings, Ted C. J.

    2015-01-01

    To defend themselves against herbivores and pathogens, plants produce numerous secondary metabolites, either constitutively or de novo in response to attacks. An intriguing constitutive example is the exudate produced by certain root-cap cells that can induce a state of reversible quiescence in plant-parasitic nematodes, thereby providing protection against these antagonists. The effect of such root exudates on beneficial entomopathogenic nematodes (EPNs) remains unclear, but could potentially impair their use in pest management programmes. We therefore tested how the exudates secreted by green pea (Pisum sativum) root caps affect four commercial EPN species. The exudates induced reversible quiescence in all EPN species tested. Quiescence levels varied with the green pea cultivars tested. Notably, after storage in root exudate, EPN performance traits were maintained over time, whereas performances of EPNs stored in water rapidly declined. In sharp contrast to high concentrations, lower concentrations of the exudate resulted in a significant increase in EPN activity and infectiousness, but still reduced the activity of two plant-parasitic nematode species. Our study suggests a finely tuned dual bioactivity of the exudate from green pea root caps. Appropriately formulated, it can favour long-term storage of EPNs and boost their infectiousness, while it may also be used to protect plants from plant-parasitic nematodes. PMID:25165149

  13. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential

    PubMed Central

    Lay, Kenneth; Kume, Tsutomu; Fuchs, Elaine

    2016-01-01

    Adult tissue stem cells (SCs) reside in niches, which orchestrate SC behavior. SCs are typically used sparingly and exist in quiescence unless activated for tissue growth. Whether parsimonious SC use is essential to conserve long-term tissue-regenerating potential during normal homeostasis remains poorly understood. Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (HFSCs). FOXC1-deficient HFSCs spend less time in quiescence, leading to markedly shortened resting periods between hair cycles. The enhanced hair cycling accelerates HFSC expenditure, and impacts hair regeneration in aging mice. Interestingly, although FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the older bulge is left unanchored. As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inner cell layer, is lost. We trace this mechanism first, to a marked increase in cell cycle-associated transcripts upon Foxc1 ablation, and second, to a downstream reduction in E-cadherin–mediated inter-SC adhesion. Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC-inhibitory factors are reduced, further lowering the threshold for HFSC activity. Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis. PMID:26912458

  14. A fast neutron spectrum unfolding method using activation measurements and its application to restoration of a thermonuclear reactor blanket neutron spectrum

    NASA Astrophysics Data System (ADS)

    Novikov, V. M.; Shkurpelov, A. A.; Zagryadsky, V. A.; Chuvilin, D. Yu.; Shmonin, Yu. V.

    1982-12-01

    This article describes a fast neutron spectrum unfolding program. The program takes into account a priori information about the neutron spectrum, the experimental values of activation integrals errors and activation detector cross sections errors. The usefulness of the unfolding program was demonstrated by its application to the determination of neutron spectra from 1 to 14 MeV in the molten-salt blanket model of a thermonuclear reactor.

  15. alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells.

    PubMed

    Cailleteau, Laurence; Estrach, Soline; Thyss, Raphael; Boyer, Laurent; Doye, Anne; Domange, Barbara; Johnsson, Nils; Rubinstein, Eric; Boucheix, Claude; Ebrahimian, Teni; Silvestre, Jean-Sebastien; Lemichez, Emmanuel; Meneguzzi, Guerrino; Mettouchi, Amel

    2010-07-15

    Integrin receptors and their extracellular matrix ligands provide cues to cell proliferation, survival, differentiation and migration. Here, we show that alpha2beta1 integrin, when ligated to the basement membrane component laminin-1, triggers a proliferation arrest in primary endothelial cells. Indeed, in the presence of strong growth signals supplied by growth factors and fibronectin, alpha2beta1 engagement alters assembly of mature focal adhesions by alpha5beta1 and leads to impairment of downstream signaling and cell-cycle arrest in the G1 phase. Although the capacity of alpha5beta1 to signal for GTP loading of Rac is preserved, the joint engagement of alpha2beta1 interferes with membrane anchorage of Rac. Adapting the 'split-ubiquitin' sensor to screen for membrane-proximal alpha2 integrin partners, we identified the CD9 tetraspanin and further establish its requirement for destabilization of focal adhesions, control of Rac subcellular localization and growth arrest induced by alpha2beta1 integrin. Altogether, our data establish that alpha2beta1 integrin controls endothelial cell commitment towards quiescence by triggering a CD9-dependent dominant signaling.

  16. PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation.

    PubMed

    Levesque, Christine; Couture, Frédéric; Kwiatkowska, Anna; Desjardins, Roxane; Guérin, Brigitte; Neugebauer, Witold A; Day, Robert

    2015-02-28

    Prostate cancer is the leading cancer in North American men. Current pharmacological treatments are limited to anti-androgen strategies and the development of new therapeutic approaches remains a challenge. As a fundamentally new approach, we propose the inhibition of PACE4, a member of the proprotein convertases family of enzymes, as a therapeutic target in prostate cancer. We developed an inhibitor named the Multi-Leu peptide, with potent in vitro anti-proliferative effects. However, the Multi-Leu peptide has not been tested under in vivo conditions and its potency under such conditions is most likely limited, due to the labile characteristics of peptides in general. Using a peptidomimetic approach, we modified the initial scaffold, generating the analog Ac-[DLeu]LLLRVK-Amba, which demonstrates increased inhibitory potency and stability. The systemic administration of this peptidomimetic significantly inhibits tumor progression in the LNCaP xenograft model of prostate cancer by inducing tumor cell quiescence, increased apoptosis and neovascularization impairment. Pharmacokinetic and biodistribution profiles of this inhibitor confirm adequate tumor delivery properties of the compound. We conclude that PACE4 peptidomimetic inhibitors could result in stable and potent drugs for a novel therapeutic strategy for prostate cancer.

  17. PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation

    PubMed Central

    Levesque, Christine; Couture, Frédéric; Kwiatkowska, Anna; Desjardins, Roxane; Guérin, Brigitte; Neugebauer, Witold A.; Day, Robert

    2015-01-01

    Prostate cancer is the leading cancer in North American men. Current pharmacological treatments are limited to anti-androgen strategies and the development of new therapeutic approaches remains a challenge. As a fundamentally new approach, we propose the inhibition of PACE4, a member of the proprotein convertases family of enzymes, as a therapeutic target in prostate cancer. We developed an inhibitor named the Multi-Leu peptide, with potent in vitro anti-proliferative effects. However, the Multi-Leu peptide has not been tested under in vivo conditions and its potency under such conditions is most likely limited, due to the labile characteristics of peptides in general. Using a peptidomimetic approach, we modified the initial scaffold, generating the analog Ac-[DLeu]LLLRVK-Amba, which demonstrates increased inhibitory potency and stability. The systemic administration of this peptidomimetic significantly inhibits tumor progression in the LNCaP xenograft model of prostate cancer by inducing tumor cell quiescence, increased apoptosis and neovascularization impairment. Pharmacokinetic and biodistribution profiles of this inhibitor confirm adequate tumor delivery properties of the compound. We conclude that PACE4 peptidomimetic inhibitors could result in stable and potent drugs for a novel therapeutic strategy for prostate cancer. PMID:25682874

  18. Quiescence of Memory CD8(+) T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4.

    PubMed

    Kalia, Vandana; Penny, Laura Anne; Yuzefpolskiy, Yevgeniy; Baumann, Florian Martin; Sarkar, Surojit

    2015-06-16

    Immune memory cells are poised to rapidly expand and elaborate effector functions upon reinfection yet exist in a functionally quiescent state. The paradigm is that memory T cells remain inactive due to lack of T cell receptor (TCR) stimuli. Here, we report that regulatory T (Treg) cells orchestrate memory T cell quiescence by suppressing effector and proliferation programs through inhibitory receptor, cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4). Loss of Treg cells resulted in activation of genome-wide transcriptional programs characteristic of effector T cells and drove transitioning as well as established memory CD8(+) T cells toward terminally differentiated KLRG-1(hi)IL-7Rα(lo)GzmB(hi) phenotype, with compromised metabolic fitness, longevity, polyfunctionality, and protective efficacy. CTLA-4 functionally replaced Treg cells in trans to rescue memory T cell defects and restore homeostasis. These studies present the CTLA-4-CD28-CD80/CD86 axis as a potential target to accelerate vaccine-induced immunity and improve T cell memory quality in current cancer immunotherapies proposing transient Treg cell ablation.

  19. Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress

    PubMed Central

    Xiao, Nan; Jani, Kaushal; Morgan, Kelly; Okabe, Rachel; Cullen, Dana E.; Jesneck, Jonathan L.

    2012-01-01

    Aging degrades hematopoietic stem cell (HSC) functions, including stress response; however, the involved molecular pathways are incompletely defined. Murine BM conditionally deleted for One-Twenty-Two-1 (Ott1), is able to maintain lifelong hematopoiesis and has preserved numbers of long-term HSCs, yet cannot repopulate nor sustain itself after transplantation against a competitor even when Ott1 is excised after engraftment. We show, specifically under replicative stress, that Ott1-deleted HSCs have a significant reduction of the G0 cell-cycle fraction associated with self-renewal and undergo early failure. Therefore, Ott1 is required to preserve HSC quiescence during stress but not steady-state hematopoiesis. Reduced tolerance of replicative stress, increased myeloid potential, and greater absolute numbers are mutual characteristics of both Ott1-deleted and aged HSCs, and comparison of their gene expression profiles reveals a shared signature. Ott1-deleted HSCs share multiple aging-associated physiologic changes, including increases in NF-κB activation and DNA damage. Loss of Ott1 causes increased reactive oxygen species; however, antioxidant treatment does not rescue the competitive defect, indicating the existence of additional essential Ott1-dependent HSC pathways. In conclusion, our data establish a requirement for Ott1 in stress hematopoiesis and suggest that Ott1-dependent processes may converge with those affected by aging. PMID:22490678

  20. Quiescence of Asian dust events in South Korea and Japan during 2012 spring: Dust outbreaks and transports

    NASA Astrophysics Data System (ADS)

    Lee, Yun Gon; Ho, Chang-Hoi; Kim, Joo-Hong; Kim, Jhoon

    2015-08-01

    This study examined the quiescence of Asian dust events in South Korea and Japan during the spring of 2012, presenting a synoptic characterization and suggesting possible causes. Synoptic observation reports from the two countries confirmed that spring 2012 had the lowest number of dust events in 2000-2012. The monthly dust frequency (DF) in March 2012 over the dust source regions, i.e., deserts in northern China and Mongolia, indicated a significant decrease compared to the 12 year (2000-2011) March climatology. The DF in April 2012 was comparable to the 12 year climatology values, but in May 2012 it was slightly lower. The daily Ozone Monitoring Instrument Aerosol Index and the Navy Aerosol Analysis and Prediction System simulations revealed stagnant dust movement in March and May 2012. Anomalous anticyclones north of the source regions decreased the dust outbreaks and enhanced the southeasterly winds, resulting in few dust events over the downwind countries (i.e., South Korea and Japan). By contrast, in April 2012, a strong anomalous cyclone east of Lake Baikal slightly increased the dust outbreaks over northeastern China. However, the major dust outbreaks were not transported downwind because of exceptional dust pathways, i.e., the southeastward pathway of dust transport was unusually blocked by the expansion of an anomalous anticyclonic circulation over the Sea of Okhotsk, with dust being transported northeast.

  1. Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.

    PubMed

    Basak, Onur; Beumer, Joep; Wiebrands, Kay; Seno, Hiroshi; van Oudenaarden, Alexander; Clevers, Hans

    2017-02-02

    Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem cells can be cultured into three-dimensional organoids containing all intestinal epithelial cell types at near-normal ratios. Conditions to generate the main cell types (enterocyte, goblet cells, Paneth cells, and M cells) are well established, but signals to induce the spectrum of hormone-producing enteroendocrine cells (EECs) have remained elusive. Here, we induce Lgr5+ stem cell quiescence in vitro by blocking epidermal growth factor receptor (EGFR) or mitogen-associated protein kinase (MAPK) signaling pathways in organoids and show that their quiescent state is readily reverted. Quiescent Lgr5+ stem cells acquire a distinct molecular signature biased toward EEC differentiation. Indeed, combined inhibition of Wnt, Notch, and MAPK pathways efficiently generates a diversity of EEC hormone-expressing subtypes in vitro. Our observations uncouple Wnt-dependent stem cell maintenance from EGF-dependent proliferation and provide an approach for the study of the elusive EECs in a defined environment.

  2. Increased radial glia quiescence, decreased reactivation upon injury and unaltered neuroblast behavior underlie decreased neurogenesis in the aging zebrafish telencephalon.

    PubMed

    Edelmann, Kathrin; Glashauser, Lena; Sprungala, Susanne; Hesl, Birgit; Fritschle, Maike; Ninkovic, Jovica; Godinho, Leanne; Chapouton, Prisca

    2013-09-01

    The zebrafish has recently become a source of new data on the mechanisms of neural stem cell (NSC) maintenance and ongoing neurogenesis in adult brains. In this vertebrate, neurogenesis occurs at high levels in all ventricular regions of the brain, and brain injuries recover successfully, owing to the recruitment of radial glia, which function as NSCs. This new vertebrate model of adult neurogenesis is thus advancing our knowledge of the molecular cues in use for the activation of NSCs and fate of their progeny. Because the regenerative potential of somatic stem cells generally weakens with increasing age, it is important to assess the extent to which zebrafish NSC potential decreases or remains unaltered with age. We found that neurogenesis in the ventricular zone, in the olfactory bulb, and in a newly identified parenchymal zone of the telencephalon indeed declines as the fish ages and that oligodendrogenesis also declines. In the ventricular zone, the radial glial cell population remains largely unaltered morphologically but enters less frequently into the cell cycle and hence produces fewer neuroblasts. The neuroblasts themselves do not change their behavior with age and produce the same number of postmitotic neurons. Thus, decreased neurogenesis in the physiologically aging zebrafish brain is correlated with an increasing quiescence of radial glia. After injuries, radial glia in aged brains are reactivated, and the percentage of cell cycle entry is increased in the radial glia population. However, this reaction is far less pronounced than in younger animals, pointing to irreversible changes in aging zebrafish radial glia.

  3. Mechanical tests of the conduit tubes of a conductor for the Toroidal winding of the International Thermonuclear Experimental Reactor (ITER)

    NASA Astrophysics Data System (ADS)

    Krivykh, A. V.; Anashkin, O. P.; Keilin, V. E.; Diev, D. N.; Dinisilov, A. S.; Shcherbakov, V. I.; Tronza, V. I.

    2012-11-01

    Extremely stringent requirements, which include the impact toughness at the liquid-helium temperature, are imposed on the material of the conduit tubes for International Thermonuclear Experimental Reactor (ITER) Toroidal Field (TF) conductors. Modified 316LN-IG stainless steel is recommended as the conduit tube material. Steel 316LN-IG tube samples (both full-size samples and sub-sized samples) are subjected to mechanical tests at various stages of the process of conductor production: in the as-recieved state and after compacting, preliminary elongation by 2.5% at room temperature, and annealing at 650°C for 200 h in a pure helium gas atmosphere. The tests are carried out at room, liquid nitrogen, and liquid helium temperatures and satisfy the standards of the American Society of Mechanical Engineers (ASME and ASTM). The results of sub-size and full-size samples testing show that the last one gives more representative results to qualify the weld joints in liquid nitrogen. When the temperature decreases or the strain increases, the magnetization of the samples increases, especially in the weld area. Strain measurements with an extensometer demonstrate that the intracrystal processes occurring at the liquid-helium temperature can lead to a significant change in the local load, up to complete unloading in a deformation zone. Unusual local serrated deformation is observed with an extensometer installed in the weld area during tests in liquid helium: this deformation is the result of compressive jumps opposite to the loading direction.

  4. Rotigotine in the treatment of primary restless legs syndrome: A meta-analysis of randomized placebo-controlled trials.

    PubMed

    Ding, Jun; Fan, Wei; Chen, Hong-hui; Yan, Peng; Sun, Sheng-gang; Zheng, Jin

    2015-04-01

    The aim of this study was to summarize the efficacy and tolerability of rotigotine in the treatment of primary restless legs syndrome (RLS). PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for English-language randomized controlled trials (RCTs) that assessed the effectiveness of rotigotine for RLS. The pooled mean change from baseline in International RLS (IRLS) Study Group Rating Scalescore and relative risk (RR) of response based on the Clinical Global Impression-Improvement (CGI-I) scale score were applied to evaluate the outcomes. The pooled proportions of adverse events (AEs) were also estimated. Six RCTs were included. The meta-analysis showed a favorable effectiveness of rotigotine versus placebo on RLS [mean change on IRLS score: mean difference (MD)=-4.80; 95% confidence interval (CI): -5.90 to -3.70; P<0.00001 and RR of response on CGI-I was 2.19; 95% CI: 1.86 to 2.58, P<0.00001]. The most common AEs were application site reactions, nausea, headache and fatigue. In general, rotigotine was well-tolerated in patients with primary RLS. Based on the findings from the meta-analysis, rotigotine was more significantly efficacious in the treatment of RLS than placebo. Nevertheless, long-term studies and more evidence of comparisons of rotigotine with other dopamine agonists are needed.

  5. Evaluation of Temperament and Character Features as Risk Factors for Depressive Symptoms in Patients with Restless Legs Syndrome

    PubMed Central

    Gazioglu, Sibel; Can Usta, Nuray; Ozkorumak, Evrim; Ayar, Ahmet; Topbas, Murat; Boz, Cavit

    2014-01-01

    Background and Purpose Restless legs syndrome (RLS) is a common sleep-related movement disorder that is frequently associated with psychological disturbances. Personality traits are of considerable importance with respect to coping with chronic illness and disease vulnerability. This study assessed the temperament and character traits of RLS patients using an approach that involves the psychobiological model of personality. Methods The personality features of 65 newly diagnosed and untreated RLS patients with no neurological or psychiatric diseases and 109 healthy controls were determined using the Temperament and Character Inventory and compared using covariance analyses. The International RLS Study Group Severity Scale was used to assess the severity of the RLS symptoms, and the Beck Depression Inventory was used to assess the presence and severity of depressive symptoms. Results RLS patients scored significantly higher than healthy controls on the temperament dimension of harm avoidance (HA, p=0.02) and significantly lower on self-directedness (SD, p=0.001). No significant difference was observed in terms of the temperament dimension of novelty seeking (p=0.435). HA scores were significantly correlated with the BDI score but not with the RLS severity or duration. Conclusions High HA and low SD scores are the main characterizing personality features of RLS patients. These personality dimensions may be among the factors predisposing patients to development of the depressive symptoms that are frequently associated with RLS. PMID:25324881

  6. Transient Willis-Ekbom's disease (restless legs syndrome) during pregnancy may be caused by estradiol-mediated dopamine overmodulation.

    PubMed

    Pereira, José Carlos; Rocha e Silva, Ingrid Ramos; Pradella-Hallinan, Márcia

    2013-02-01

    Willis-Ekbom's disease (WED), formerly called restless legs syndrome, is more common in pregnant than in non-pregnant women, implying that the physiological and biochemical changes during pregnancy influence its development. During pregnancy, many hormone levels undergo significant changes, and some hormones significantly increase in activity and can interfere with other hormones. For example, the steroid hormone estradiol interferes with the neuroendocrine hormone dopamine. During pregnancy, the activity of the thyroid axis is enhanced to meet the increased demand for thyroid hormones during this state. Dopamine is a neuroendocrine hormone that diminishes the levels of thyrotropin and consequently of thyroxine, and one of the roles of the dopaminergic system is to counteract the activity of thyroid hormones. When the activity of dopamine is not sufficient to modulate thyroid hormones, WED may occur. Robust evidence in the medical literature suggests that an imbalance between thyroid hormones and the dopaminergic system underpins WED pathophysiology. In this article, we present evidence that this imbalance may also mediate transient WED during pregnancy. It is possible that the main hormonal alteration responsible for transient WED of pregnancy is the excessive modulation of dopamine release in the pituitary stalk by estradiol. The reduced quantities of dopamine then cause decreased modulation of thyrotropin, leading to enhanced thyroid axis activity and subsequent WED symptoms. Iron deficiency may also be a predisposing factor for WED during pregnancy, as it can both diminish dopamine and increase thyroid hormone.

  7. A new design of a polysomnography-based multi-center treatment study for the restless legs syndrome.

    PubMed

    Penzel, T; Brandenburg, U; Peter, J H; Otto, R; Hundemer, H P; Lledo, A; Wetter, T C; Trenkwalder, C

    2002-04-01

    Periodic limb movements (PLM) cause sleep disorders and daytime symptoms and are frequently associated with restless legs syndrome (RLS). Treatment of RLS with increased PLM during sleep (PLMS) has been evaluated in studies limited in size, methodology and study length. This long-term, placebo-controlled, multi-center, study with polysomnography (PSG) recordings has been designed in order to assess efficacy and safety parameters of pergolide treatment in RLS. This novel approach for a study was created to assure consistently high quality of sleep recording and analysis. Using defined criteria, 21 sleep centers were approved for the study after a pilot phase. Seventeen centers with 16 different PSG systems randomized 100 patients. Digital sleep recordings from 4 visits (baseline, 6 weeks, 6 months, 1 year) were submitted to one central evaluation center following previously defined standardized operating procedures. Visual scoring of all recordings was performed by one independent scorer. Reliability of scoring was evaluated for 20 randomly selected baseline recordings. The mean epoch by epoch agreement for sleep stages was 88% (range 81-96%), mean arousal re-scoring differed by 0.5 (range: -16 to 20), and mean PLM index re-scoring differed by 0.1 (range: -1.5 to 2.1). Using one scorer with a demonstrated high reliability in PSG scoring for all sleep recordings was very effective in terms of study cost, study duration, and data quality.

  8. In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine.

    PubMed

    Ferré, Sergi; Earley, Christopher; Gulyani, Seema; Garcia-Borreguero, Diego

    2017-03-01

    Dopaminergic drugs have been used as the first-line treatment for restless legs syndrome (RLS) for many years and are considered to be, at least over the short-term, effective and safe. However, the main long-term complication of dopaminergic treatment is augmentation, which is an overall increase in symptom severity and intensity, with symptoms starting earlier in the afternoon and expanding to previously unaffected parts of the body. Augmentation is a common complication, with prevalence rates of nearly 50%, and is a common cause of treatment failure. Furthermore, augmentation occurs almost exclusively during treatment with dopaminergic drugs. Due to its frequency, there is a strong clinical need for treatment alternatives to dopaminergic drugs. Moreover, recent treatment guidelines recommend that treatment be initiated, whenever possible, with non-dopaminergic drugs (ie, α2δ ligands). Alternative treatments such as intravenous iron preparations directly address iron deficiency, as well as the consequences of iron deficiency in regard to glutamate and adenosine. This article also reviews current knowledge supporting an involvement of glutamatergic and adenosinergic neurotransmission in the pathophysiology of RLS, and explores the potential development of drugs acting on both systems.

  9. Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

    PubMed Central

    Spieler, Derek; Kaffe, Maria; Knauf, Franziska; Bessa, José; Tena, Juan J.; Giesert, Florian; Schormair, Barbara; Tilch, Erik; Lee, Heekyoung; Horsch, Marion; Czamara, Darina; Karbalai, Nazanin; von Toerne, Christine; Waldenberger, Melanie; Gieger, Christian; Lichtner, Peter; Claussnitzer, Melina; Naumann, Ronald; Müller-Myhsok, Bertram; Torres, Miguel; Garrett, Lillian; Rozman, Jan; Klingenspor, Martin; Gailus-Durner, Valérie; Fuchs, Helmut; Hrabě de Angelis, Martin; Beckers, Johannes; Hölter, Sabine M.; Meitinger, Thomas; Hauck, Stefanie M.; Laumen, Helmut; Wurst, Wolfgang; Casares, Fernando; Gómez-Skarmeta, Jose Luis; Winkelmann, Juliane

    2014-01-01

    Genome-wide association studies (GWAS) identified the MEIS1 locus for Restless Legs Syndrome (RLS), but causal single nucleotide polymorphisms (SNPs) and their functional relevance remain unknown. This locus contains a large number of highly conserved noncoding regions (HCNRs) potentially functioning as cis-regulatory modules. We analyzed these HCNRs for allele-dependent enhancer activity in zebrafish and mice and found that the risk allele of the lead SNP rs12469063 reduces enhancer activity in the Meis1 expression domain of the murine embryonic ganglionic eminences (GE). CREB1 binds this enhancer and rs12469063 affects its binding in vitro. In addition, MEIS1 target genes suggest a role in the specification of neuronal progenitors in the GE, and heterozygous Meis1-deficient mice exhibit hyperactivity, resembling the RLS phenotype. Thus, in vivo and in vitro analysis of a common SNP with small effect size showed allele-dependent function in the prospective basal ganglia representing the first neurodevelopmental region implicated in RLS. PMID:24642863

  10. Zolpidem Induced Sleep-related Eating and Complex Behaviors in a Patient with Obstructive Sleep Apnea and Restless Legs Syndrome

    PubMed Central

    Park, Young-Min; Shin, Hyun-Woo

    2016-01-01

    Zolpidem-induced sleep-related complex behaviors (SRCB) with anterograde amnesia have been reported. We describe herein a case in which the development of zolpidem-induced sleep-related eating disorder (SRED) and SRCB was strongly suspected. A 71-year-old Korean male was admitted to the Department of Psychiatry due to his repetitive SRED and SRCB with anterograde amnesia, which he reported as having occurred since taking zolpidem. The patient also had restless legs syndrome (RLS) and obstructive sleep apnea (OSA). His baseline serum iron level was low at admission. Zolpidem discontinuation resulted in the immediate disappearance of his SRED, but did not affect his RLS symptoms. These symptoms rapidly improved after adding a single i.v. iron injection once daily, and so he was discharged to day-clinic treatment. These findings indicate that zolpidem can induce SRCB. Although the pathophysiology of zolpidem-induced SRED and other SRCB remains unclear, clinicians should carefully monitor for the potential induction of complex behaviors associated with zolpidem in patients with comorbid RLS or OSA. PMID:27489385

  11. Smoking-Related Correlates of Psychomotor Restlessness and Agitation in a Community Sample of Daily Cigarette Smokers

    PubMed Central

    Wong, Jordan A.; Leventhal, Adam M.

    2015-01-01

    Background and Objectives Psychomotor restlessness and agitation (PMA) is a putatively important, yet understudied, psychopathologic correlate of smoking. The scant smoking research on PMA previously conducted has been narrow in scope and conducted among psychiatric patients. To examine the generalizability and relevance of PMA to smoking, this cross-sectional study investigated associations between PMA and a variety of smoking processes in a community sample. Methods Participants in this study were non-treatment-seeking smokers (N = 254, ≥10 cig/day, M age = 44 years) from the community without an active mood disorder. At baseline, they completed a PMA symptom checklist, a composite depressive symptom index, and a battery of smoking questionnaires. Results Linear regression models adjusting for depressive symptoms and demographics indicated that PMA level was positively associated with severity of nicotine withdrawal symptoms during prior quit attempts (β = .18, p < .05), anticipated likelihood of withdrawal in a future quit attempt (β = .19, p < .05), motivation to smoke for negative reinforcement (β = .14, p < .05), and smoking expectancies for negative reinforcement (β = .17, p < .05), negative consequences (β = .22, p < .01), and positive reinforcement (β = .14, p < .05). PMA was not significantly associated with smoking chronicity, frequency, or dependence severity. Conclusion and Scientific Significance Smokers with elevated PMA appear to experience greater smoking-induced affect modulation and nicotine withdrawal than the average smoker, regardless of other depressive symptoms. Given that PMA differentiates a qualitatively unique profile of smoking characteristics, PMA warrants consideration in tobacco addiction research and practice. PMID:25864606

  12. Neurocognitive function in patients with idiopathic Restless Legs Syndrome before and after treatment with dopamine-agonist.

    PubMed

    Galbiati, Andrea; Marelli, Sara; Giora, Enrico; Zucconi, Marco; Oldani, Alessandro; Ferini-Strambi, Luigi

    2015-03-01

    Although a huge amount of clinical evidence for Restless Legs Syndrome (RLS) is present in literature, an exhaustive account of cognitive profile in RLS patients is still lacking. In this study we evaluated the neurocognitive function in RLS patients and the effects of a three-month treatment with a dopamine agonist (pramipexole) at low doses. Clinical and polysomnographic characteristics, cognitive abilities, quality of life and psychological clinical indices were assessed in 20 RLS patients and 15 age-matched controls. The neurocognitive results, obtained by untreated RLS patients (baseline), were firstly compared to those of controls and then to those of the same RLS group after treatment (follow-up). Increased Total Sleep Time, Slow Wave Sleep, Sleep Efficiency and decreased Sleep Latency, Wake After Sleep Onset and periodic leg movement index were found by polysomnographic recording after a three-month treatment. Results showed that cognitive functions, impaired at baseline when compared to control subjects, improved after the pharmacological treatment, reaching the scores of healthy subjects. Decision making, problem solving and categorizing abilities, investigated by the Iowa Gambling Task (IGT) and the Wisconsin Card Sorting Test (WCST), resulted lower in RLS patients at baseline than in controls. All these functions improved after pharmacological treatment, as well as quality of life, depressive and anxiety symptoms, and daytime sleepiness.

  13. Did a Stress Change due to a Long-Term Slow Slip Event in the Tokai Region Cause Distant Seismic Quiescence in the Tamba Region, Japan?

    NASA Astrophysics Data System (ADS)

    Sugaya, K.; Hiramatsu, Y.; Furumoto, M.; Katao, H.

    2008-12-01

    Seismic quiescence is useful information for the earthquake prediction. Relationships between seismicity rate change and stressing rate change have been reported by theoretical and observational studies (Dieterich, 1994; Toda et al., 2002). Recently, Ogata (2007) showed that a silent slip event might occur within the source region of an intraplate earthquake preceding the rupture from seismicity rate changes and GPS anomalies. The Tamba region in southwest Japan is located to the northeast of the rupture zone of the 1995 Hyogo-ken Nanbu Earthquake (Mjma 7.3). In the region, the seismicity was activated by a coseismic static stress change (+20kPa; Hiramatsu et al., 2000) due to the event. A distinct decrease in seismicity rate of microearthquakes was recognized in 2003 (Katao, 2005). Such a seismic quiescence had continued for two and a half years before the event (DPRI, 1999). It has, therefore, been controversial whether a major earthquake follows the quiescence or not (e.g., Umeda et al., 2005). We showed that the Tamba region was located in a region where Δ CFS decreased (-0.5kPa/yr) due to the long-term slow slip event (SSE) in the Tokai region and indicated that the beginning of the quiescence seemed to be associated with that of the event (Sugaya et al., 2007IUGG). Our purpose in this study is to investigate whether the quiescence in the Tamba region is caused by the stress change due to the long-term SSE or not based on the rate- and state- friction law (Dieterich, 1994). We use the hypocentral catalog of the DPRI from 1987 to 2001 and that relocated in this study from 2002 to 2006. We use declustered earthquakes (Reasenberg, 1985) greater than or equal to M 2.5 for following analyses. We find that the seismicity in the Tamba region after the 1995 Hyogo-ken Nanbu earthquake is explained by the Omori"fs law (p=1) than the ETAS model (Ogata, 1986). The seismicity is, thus, interpreted as the aftershock-type activity of the earthquake. We estimate Aσ (A is

  14. Characterizing X-Ray and Radio Emission in the Black Hole X-Ray Binary V404 Cygni during Quiescence

    NASA Astrophysics Data System (ADS)

    Rana, Vikram; Loh, Alan; Corbel, Stephane; Tomsick, John A.; Chakrabarty, Deepto; Walton, Dominic J.; Barret, Didier; Boggs, Steven E.; Christensen, Finn E.; Craig, William; Fuerst, Felix; Gandhi, Poshak; Grefenstette, Brian W.; Hailey, Charles; Harrison, Fiona A.; Madsen, Kristin K.; Rahoui, Farid; Stern, Daniel; Tendulkar, Shriharsh; Zhang, William W.

    2016-04-01

    We present results from multi-wavelength simultaneous X-ray and radio observations of the black hole X-ray binary V404 Cyg in quiescence. Our coverage with NuSTAR provides the very first opportunity to study the X-ray spectrum of V404 Cyg at energies above 10 keV. The unabsorbed broadband (0.3-30 keV) quiescent luminosity of the source is 8.9 × 1032 erg s-1 for a distance of 2.4 kpc. The source shows clear variability on short timescales (an hour to a couple of hours) in the radio, soft X-ray, and hard X-ray bands in the form of multiple flares. The broadband X-ray spectra obtained from XMM-Newton and NuSTAR can be characterized with a power-law model having a photon index of Γ = 2.12 ± 0.07 (90% confidence errors); however, residuals at high energies indicate spectral curvature significant at a 3σ confidence level with the e-folding energy of the cutoff as {20}-7+20 keV. Such curvature can be explained using synchrotron emission from the base of a jet outflow. Radio observations using the VLA reveal that the spectral index evolves on very fast timescales (as short as 10 minutes), switching between optically thick and thin synchrotron emission, possibly due to instabilities in the compact jet or stochastic instabilities in the accretion rate. We explore different scenarios to explain this very fast variability.

  15. The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells

    PubMed Central

    Giangrande, Angela; Martinelli, Giovanni; Guadagnuolo, Viviana; Simonetti, Giorgia; Perini, Giovanni; Bernardoni, Roberto

    2016-01-01

    The efficient treatment of hematological malignancies as Acute Myeloid Leukemia, myelofibrosis and Chronic Myeloid Leukemia, requires the elimination of cancer-initiating cells and the prevention of disease relapse through targeting pathways that stimulate generation and maintenance of these cells. In mammals, inhibition of Smoothened, the key mediator of the Hedgehog signaling pathway, reduces Chronic Myeloid Leukemia progression and propagation. These findings make Smo a candidate target to inhibit maintenance of leukemia-initiating cells. In Drosophila melanogaster the same pathway maintains the hematopoietic precursor cells of the lymph gland, the hematopoietic organ that develops in the larva. Using Drosophila as an in vivo model, we investigated the mode of action of PF-04449913, a small-molecule inhibitor of the human Smo protein. Drosophila larvae fed with PF-04449913 showed traits of altered hematopoietic homeostasis. These include the development of melanotic nodules, increase of circulating hemocytes, the size increase of the lymph gland and accelerated differentiation of blood cells likely due to the exit of multi-potent precursors from quiescence. Importantly, the Smo inhibition can lead to the complete loss of hematopoietic precursors. We conclude that PF-04449913 inhibits Drosophila Smo blocking the Hh signaling pathway and causing the loss of hematopoietic precursor cells. Interestingly, this is the effect expected in patients treated with PF-04449913: number decrease of cancer initiating cells in the bone marrow to reduce the risk of leukemia relapse. Altogether our results indicate that Drosophila comprises a model system for the in vivo study of molecules that target evolutionary conserved pathways implicated in human hematological malignancies. PMID:27486815

  16. XPS, SIMS and FTIR-ATR characterization of boronized graphite from the thermonuclear plasma device RFX-mod

    NASA Astrophysics Data System (ADS)

    Ghezzi, F.; Laguardia, L.; Caniello, R.; Canton, A.; Dal Bello, S.; Rais, B.; Anderle, M.

    2015-11-01

    In this paper the characterization of a thin (tens of nanometers) boron layer on fine grain polycrystalline graphite substrate is presented. The boron film is used as conditioning technique for the full graphite wall of the Reversed Field eXperiment-modified (RFX-mod) experiment, a device for the magnetic confinement of plasmas of thermonuclear interest. Aim of the present analysis is to enlighten the chemical structure of the film, the trapping mechanism that makes it a getter for oxygen and hydrogen and the reason of its loss of effectiveness after exposure to about 100 s of hydrogen plasma. X-ray Photoelectron Spectroscopy (XPS), Secondary Ions Mass Spectrometry (SIMS) and Fourier Transform Infra Red spectroscopy in combination with the Attenuated Total Reflectance (FTIR-ATR) were used to obtain the structure and the chemical composition of graphitic samples as coated or coated and subsequently exposed to hydrogen plasma after boron deposition. The boron layers on the only coated samples were found to be amorphous hydrogenated boron carbide plus a variety of bonds like B-B, B-H, B-O, B-OH, C-C, C-H, C-O, C-OH. Both the thickness and the homogeneity of the layers were found to depend on the distance of the sample from the anode during the deposition. The samples contained oxygen along the layer thickness, at level of 5%, bound to boron. The gettering action of the boron is therefore already active during the deposition itself. The exposure to plasma caused erosion of the boron film and higher content of H and O bound to boron throughout the whole thickness. The interaction of the B layer with plasma is therefore a bulk phenomenon.

  17. Probing the effects of a thermonuclear X-ray burst on the neutron star accretion flow with NuSTAR

    NASA Astrophysics Data System (ADS)

    Degenaar, N.; Koljonen, K. I. I.; Chakrabarty, D.; Kara, E.; Altamirano, D.; Miller, J. M.; Fabian, A. C.

    2016-03-01

    Observational evidence has been accumulating that thermonuclear X-ray bursts ignited on the surface of neutron stars influence the surrounding accretion flow. Here, we exploit the excellent sensitivity of NuSTAR up to 79 keV to analyse the impact of an X-ray burst on the accretion emission of the neutron star LMXB 4U 1608-52. The ≃200 s long X-ray burst occurred during a hard X-ray spectral state, and had a peak intensity of ≃30-50 per cent of the Eddington limit with no signs of photospheric radius expansion. Spectral analysis suggests that the accretion emission was enhanced up to a factor of ≃5 during the X-ray burst. We also applied a linear unsupervised decomposition method, namely non-negative matrix factorization (NMF), to study this X-ray burst. We find that the NMF performs well in characterizing the evolution of the burst emission and is a promising technique to study changes in the underlying accretion emission in more detail than is possible through conventional spectral fitting. For the burst of 4U 1608-52, the NMF suggests a possible softening of the accretion spectrum during the X-ray burst, which could potentially be ascribed to cooling of a corona. Finally, we report a small (≃3 per cent) but significant rise in the accretion emission ≃0.5 h before the X-ray burst, although it is unclear whether this was related to the X-ray burst ignition.

  18. The Joint European Torus (JET) pumped divertor results and their significance for the International Thermonuclear Experimental Reactor (ITER)

    NASA Astrophysics Data System (ADS)

    Watkins, M. L.; JET Team

    1996-05-01

    The effectiveness of the pumped divertor during the 1994/95 experimental campaign of the Joint European Torus (JET) [P.-H. Rebut, R. J. Bickerton, and B. E. Keen, Nucl. Fusion 25, 1011 (1985)] has allowed the pursuit of a broad-based research program that is highly relevant to the International Thermonuclear Experimental Reactor (ITER) [K. Tomabechi and the ITER Team, Nucl. Fusion 31, 1135 (1991)]. High-performance hot-ion discharges with high confinement (H-modes) free of edge localized modes (ELMs) have set a JET record neutron rate in deuterium, but are limited by various magnetohydrodynamic (MHD) phenomena to βN<1.8, where βN=β/(I/aB), β is the ratio of the plasma pressure to the toroidal field pressure, I is the plasma current, B is the toroidal field, and a is the horizontal minor radius of the plasma. Quasi-steady-state ELMy H-modes have also been studied at high power, high current, and high β. The underlying energy transport exhibits a gyro-Bohm dependence that is lost close to the H-mode threshold and at high β. ELMy H-modes with detached divertor plasmas and radiative power exhaust (the operating regime foreseen for ITER) reduce the power loading to the targets, but at the expense of main plasma confinement and purity. Beryllium has been compared with carbon fiber composite as a divertor target material and melting has been induced at ITER reference off-normal heat loads, but only a moderate degree of self-protection of the beryllium target was found.

  19. X-Ray Reflection and an Exceptionally Long Thermonuclear Helium Burst from IGR J17062-6143

    NASA Astrophysics Data System (ADS)

    Keek, L.; Iwakiri, W.; Serino, M.; Ballantyne, D. R.; in’t Zand, J. J. M.; Strohmayer, T. E.

    2017-02-01

    Thermonuclear X-ray bursts from accreting neutron stars power brief but strong irradiation of their surroundings, providing a unique way to study accretion physics. We analyze MAXI/Gas Slit Camera and Swift/XRT spectra of a day-long flash observed from IGR J17062-6143 in 2015. It is a rare case of recurring bursts at a low accretion luminosity of 0.15% Eddington. Spectra from MAXI, Chandra, and NuSTAR observations taken between the 2015 burst and the previous one in 2012 are used to determine the accretion column. We find it to be consistent with the burst ignition column of 5 × 1010 g cm‑2, which indicates that it is likely powered by burning in a deep helium layer. The burst flux is observed for over a day, and decays as a straight power law: F ∝ t ‑1.15. The burst and persistent spectra are well described by thermal emission from the neutron star, Comptonization of this emission in a hot optically thin medium surrounding the star, and reflection off the photoionized accretion disk. At the burst peak, the Comptonized component disappears, when the burst may dissipate the Comptonizing gas, and it returns in the burst tail. The reflection signal suggests that the inner disk is truncated at ∼102 gravitational radii before the burst, but may move closer to the star during the burst. At the end of the burst, the flux drops below the burst cooling trend for 2 days, before returning to the pre-burst level.

  20. X-Ray Reflection and an Exceptionally Long Thermonuclear Helium Burst from IGR J17062-6143

    NASA Technical Reports Server (NTRS)

    Keek, L.; Iwakiri, W.; Serino, M.; Ballantyne, D. R.; in’t Zand, J. J. M.; Strohmayer, T. E.

    2017-01-01

    Thermonuclear X-ray bursts from accreting neutron stars power brief but strong irradiation of their surroundings, providing a unique way to study accretion physics. We analyze MAXI/Gas Slit Camera and Swift/XRT spectra of a day-long flash observed from IGR J17062-6143 in 2015. It is a rare case of recurring bursts at a low accretion luminosity of 0.15% Eddington. Spectra from MAXI, Chandra, and NuSTAR observations taken between the 2015 burst and the previous one in 2012 are used to determine the accretion column. We find it to be consistent with the burst ignition column of 5x10(exp 10) g cm (exp -2), which indicates that it is likely powered by burning in a deep helium layer. The burst flux is observed for over a day, and decays as a straight power law: F gamma t (exp -1.15). The burst and persistent spectra are well described by thermal emission from the neutron star, Comptonization of this emission in a hot optically thin medium surrounding the star, and reflection off the photoionized accretion disk. At the burst peak, the Comptonized component disappears, when the burst may dissipate the Comptonizing gas, and it returns in the burst tail. The reflection signal suggests that the inner disk is truncated at approximately 102 gravitational radii before the burst, but may move closer to the star during the burst. At the end of the burst, the flux drops below the burst cooling trend for 2 days, before returning to the pre-burst level.

  1. Neutrino Signal of Collapse-induced Thermonuclear Supernovae: The Case for Prompt Black Hole Formation in SN 1987A

    NASA Astrophysics Data System (ADS)

    Blum, Kfir; Kushnir, Doron

    2016-09-01

    Collapse-induced thermonuclear explosion (CITE) may explain core-collapse supernovae (CCSNe). We analyze the neutrino signal in CITE and compare it to the neutrino burst of SN 1987A. For strong (≳ {10}51 erg) CCSNe, such as SN 1987A, CITE predicts a proto-neutron star (PNS) accretion phase lasting up to a few seconds that is cut off by black hole (BH) formation. The neutrino luminosity can later be revived by accretion disk emission after a dead time of a few to a few tens of seconds. In contrast, the neutrino mechanism for CCSNe predicts a short (≲s) PNS accretion phase, followed by slowly declining PNS cooling luminosity. We repeat statistical analyses used in the literature to interpret the neutrino mechanism, and apply them to CITE. The first 1-2 s of the neutrino burst are equally compatible with CITE and with the neutrino mechanism. However, the data points toward a luminosity drop at t = 2-3 s, which is in some tension with the neutrino mechanism but can be naturally attributed to BH formation in CITE. The occurrence of neutrino signal events at 5 s suggests that, within CITE, the accretion disk formed by that time. We perform two-dimensional numerical simulations showing that CITE may be able to accommodate this disk formation time while reproducing the ejected 56Ni mass and ejecta kinetic energy within factors of 2-3 of observations. We estimate the accretion disk neutrino luminosity, finding it to be on the low side but compatible with the data to a factor of 10. Given comparable uncertainties in the disk luminosity simulation, we conclude that direct BH formation may have occurred in SN 1987A.

  2. Association between the neutrophil-to-lymphocyte ratio, a new marker of systemic inflammation, and restless legs syndrome

    PubMed Central

    Varım, Ceyhun; Acar, Bilgehan Atılgan; Uyanık, Mehmet Sevki; Acar, Turkan; Alagoz, Neslihan; Nalbant, Ahmet; Kaya, Tezcan; Ergenc, Hasan

    2016-01-01

    INTRODUCTION Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is characterised by abnormal sensations in the legs as well as dysaesthesia. Although the aetiology of RLS has not yet been determined, it may be associated with systemic inflammation. The neutrophil-to-lymphocyte ratio (NLR) is a new and simple marker indicating systemic inflammation. The present study aimed to investigate the relationship between systemic inflammation and RLS through the use of the NLR. METHODS A total of 75 newly diagnosed patients with RLS and 56 healthy control subjects were included in the study. Baseline NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. The NLRs of the two groups were compared. RESULTS There were no significant differences in gender and age between the two groups. The NLR was 1.96 ± 0.66 in the patient group and 1.67 ± 0.68 in the control group (p = 0.005). Receiver operating characteristic analysis was performed to determine the cut-off value of NLR to predict RLS. The NLR was predictive at 1.58 with a 64% sensitivity and 50% specificity (95% confidence interval 0.55–0.74, area under curve 0.648 ± 0.05). The NLR was found to be statistically higher in patients with RLS and may be used to predict RLS. CONCLUSION The aetiology of RLS remains undetermined. The present study showed that systemic inflammation may play a role in RLS. However, RLS could also be associated with systemic inflammatory diseases. This relationship is supported by high NLR values, which are related to chronic systemic inflammation. PMID:27662970

  3. Efficacy of Intravenous Iron Sucrose in Hemodialysis Patients with Restless Legs Syndrome (RLS): A Randomized, Placebo-Controlled Study.

    PubMed

    Deng, Yinghui; Wu, Jinglin; Jia, Qiang

    2017-03-12

    BACKGROUND Restless legs syndrome (RLS) is a common disorder in hemodialysis (HD) patients that causes sleep disturbances and diminished quality of life. Because iron deficiency has been implicated in the pathogenesis of RLS, we sought to investigate the effects of intravenous (IV) iron sucrose on symptoms of RLS in HD patients. MATERIAL AND METHODS The study was a randomized, placebo-controlled study of 1000 mg iron sucrose versus normal saline as placebo. Patients were evaluated at baseline and 2 weeks after the last injection. The severity of RLS was assessed using the International RLS Study Group rating scale (IRLS). Blood samples were taken to measure iron parameters reflecting the iron status, including serum ferritin (SF) concentration, percentage transferrin saturation (TSAT%) and hemoglobin (Hb), and other biochemical parameters as safety assessments, including creatinine (Cr), urea, intact parathyroid hormone (iPTH), and the index of urea clearance (Kt/V). Adverse events were monitored in all subjects during the period of infusion. RESULTS After 2 weeks, IRLS scores decreased more in the IV-iron group (-7.38±2.03) than in the placebo group (-0.81±2.61) (P=0.000). Serum ferritin, TSAT, and hemoglobin increased more in the IV-iron group (227.63±77.64 µg/L; 26.06±7.77%; 13.98±3.62g/L, respectively) than in the placebo group (SF, p=0.000; TSAT, p=0.000; Hb, p=0.000, respectively). There were no significant differences between IV-iron and placebo groups in Cr, urea, iPTH, and Kt/V. No adverse effects were observed in the study. CONCLUSIONS IV iron sucrose is a safe and effective treatment for reducing RLS symptoms in HD patients over the short-term.

  4. A panchromatic view of the restless SN 2009ip reveals the explosive ejection of a massive star envelope

    SciTech Connect

    Margutti, R.; Milisavljevic, D.; Soderberg, A. M.; Chornock, R.; Zauderer, B. A.; Sanders, N. E.; Berger, E.; Murase, K.; Guidorzi, C.; Kuin, P.; Fransson, C.; Levesque, E. M.; Chandra, P.; Challis, P.; Bianco, F. B.; Brown, P. J.; Chatzopoulos, E.; Cheung, C. C.; Choi, C.; and others

    2014-01-01

    The double explosion of SN 2009ip in 2012 raises questions about our understanding of the late stages of massive star evolution. Here we present a comprehensive study of SN 2009ip during its remarkable rebrightenings. High-cadence photometric and spectroscopic observations from the GeV to the radio band obtained from a variety of ground-based and space facilities (including the Very Large Array, Swift, Fermi, Hubble Space Telescope, and XMM) constrain SN 2009ip to be a low energy (E ∼ 10{sup 50} erg for an ejecta mass ∼0.5 M {sub ☉}) and asymmetric explosion in a complex medium shaped by multiple eruptions of the restless progenitor star. Most of the energy is radiated as a result of the shock breaking out through a dense shell of material located at ∼5 × 10{sup 14} cm with M ∼ 0.1 M {sub ☉}, ejected by the precursor outburst ∼40 days before the major explosion. We interpret the NIR excess of emission as signature of material located further out, the origin of which has to be connected with documented mass-loss episodes in the previous years. Our modeling predicts bright neutrino emission associated with the shock break-out if the cosmic-ray energy is comparable to the radiated energy. We connect this phenomenology with the explosive ejection of the outer layers of the massive progenitor star, which later interacted with material deposited in the surroundings by previous eruptions. Future observations will reveal if the massive luminous progenitor star survived. Irrespective of whether the explosion was terminal, SN 2009ip brought to light the existence of new channels for sustained episodic mass loss, the physical origin of which has yet to be identified.

  5. MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels

    PubMed Central

    Xiong, Lan; Catoire, Hélène; Dion, Patrick; Gaspar, Claudia; Lafrenière, Ronald G.; Girard, Simon L.; Levchenko, Anastasia; Rivière, Jean-Baptiste; Fiori, Laura; St-Onge, Judith; Bachand, Isabelle; Thibodeau, Pascale; Allen, Richard; Earley, Christopher; Turecki, Gustavo; Montplaisir, Jacques; Rouleau, Guy A.

    2009-01-01

    Restless legs syndrome (RLS) is a common neurological disorder characterized by an irresistible urge to move the legs at night, which is often accompanied by unpleasant sensations. A recent genomewide association study identified an association between RLS and intronic markers from the MEIS1 gene. Comparative genomic analysis indicates that MEIS1 is the only gene encompassed in this evolutionarily conserved chromosomal segment, i.e. a conservation synteny block, from mammals to fish. We carried out a series of experiments to delineate the role of MEIS1 in RLS pathogenesis and the underlying genetic mechanism. We sequenced all 13 MEIS1 exons and their splice junctions in 285 RLS probands with confirmed clinical diagnosis and did not identify any causative coding or exon–intron junction mutations. We found no evidence of structural variation or disease-associated haplotype differential splicing. However, sequencing of conserved regions of MEIS1 introns 8 and 9 identified a novel single nucleotide polymorphism (C13B_2) significantly associated with RLS (allelic association, P = 1.81E−07). We detected a significant decrease in MEIS1 mRNA expression by quantitative real-time polymerase chain reaction in lymphoblastoid cell lines (LCLs) and brain tissues from RLS patients homozygous for the intronic RLS risk haplotype, compared with those homozygous for the non-risk haplotype. Finally, we found significantly decreased MEIS1 protein levels in the same batch of LCLs and brain tissues from the homozygous carriers of the risk haplotype, compared with the homozygous non-carriers. Therefore, these data suggest that reduced expression of the MEIS1 gene, possibly through intronic cis-regulatory element(s), predisposes to RLS. PMID:19126776

  6. The Effect of Massage With Lavender Oil on Restless Leg Syndrome in Hemodialysis Patients: A Randomized Controlled Trial

    PubMed Central

    Hashemi, Sayyed Hossein; Hajbagheri, Ali; Aghajani, Mohammad

    2015-01-01

    Background: Restless leg syndrome (RLS) is a common problem in patients with chronic renal failure. It can reduce the quality of life and sleep disturbances. This disorder is usually treated pharmacologically. Recently, complementary medicine methods have been suggested because of chemical drugs adverse effects. There is not enough evidence about the effect of aromatherapy on RLS. Objectives: The aim of this study was to determine the effects of massage with lavender oil on RLS symptoms in hemodialysis patients. Patients and Methods: This randomized clinical trial study included 70 hemodialysis patients with RLS that were randomly assigned into two groups in 2014. The experimental group received effleurage massage using lavender oil and control group received routine care for three weeks. Data was collected with RLS questionnaire and analyzed using independent and paired t-test and Chi-square test. Results: The mean RLS scores were not significantly different in the two groups at the start of study (22.41 ± 7.67 vs. 22.90 ± 4.38, P = 0.76). At the end of study, the mean RLS score significantly decreased in the intervention group, while this score remained relatively un-changed in the control group (12.41 ± 5.49 vs. 23.23 ± 4.52, P < 0.0001). Conclusions: Lavender oil massage was effective to improve RLS in hemodialysis patients. It has no adverse effects, is practical and cost-effective. It is suggested to be used along with routine treatment of RLS in hemodialysis patients. PMID:26835466

  7. A comparison of MRI tissue relaxometry and ROI methods used to determine regional brain iron concentrations in restless legs syndrome

    PubMed Central

    Moon, Hye-Jin; Chang, Yongmin; Lee, Yeong Seon; Song, Huijin; Chang, Hyuk Won; Ku, Jeonghun; Allen, Richard P; Earley, Christopher J; Cho, Yong Won

    2015-01-01

    Purpose Magnetic resonance imaging relaxometry studies differed on the relaxometry methods and their approaches to determining the regions of interest (ROIs) in restless legs syndrome (RLS) patients. These differences could account for the variable and inconsistent results found across these studies. The aim of this study was to assess the relationship between the different relaxometry methods and different ROI approaches using each of these methods on a single population of controls and RLS subjects. Methods A 3.0-T magnetic resonance imaging with the gradient-echo sampling of free induction decay and echo pulse sequence was used. The regional brain “iron concentrations” were determined using three relaxometry metrics (R2, R2*, and R2′) through two different ROI methods. The substantia nigra (SN) was the primary ROI with red nucleus, caudate, putamen, and globus pallidus as the secondary ROIs. Results Thirty-seven RLS patients and 40 controls were enrolled. The iron concentration as determined by R2 did not correlate with either of the other two methods, while R2* and R2′ showed strong correlations, particularly for the substantia nigra and red nucleus. In the fixed-shape ROI method, the RLS group showed a lower iron index compared to the control group in the substantia nigra and several other regions. With the semi-automated ROI method, however, only the red nucleus showed a significant difference between the two groups. Conclusion Both the relaxometry and ROI determination methods significantly influenced the outcome of studies that used these methods to estimate regional brain iron concentrations. PMID:26257527

  8. Restless legs syndrome augmentation among Japanese patients receiving pramipexole therapy: Rate and risk factors in a retrospective study

    PubMed Central

    Takahashi, Masayoshi; Nishida, Shingo; Nakamura, Masaki; Kobayashi, Mina; Matsui, Kentaro; Ito, Eiki; Usui, Akira; Inoue, Yuichi

    2017-01-01

    To investigate the rate of and risk factors for restless legs syndrome (RLS) augmentation in Japanese patients receiving pramipexole (PPX) treatment. Records of 231 consecutive patients with idiopathic RLS who received PPX therapy for more than one month in a single sleep disorder center were analyzed retrospectively. Augmentation was diagnosed based on the Max Planck Institute criteria; associated factors were identified by logistic regression analysis. Mean age at PPX initiation was 60.6 ± 14.9 years and mean treatment duration was 48.5 ± 26.4 months. Augmentation was diagnosed in 21 patients (9.1%). Daily PPX dose and treatment duration were significantly associated with augmentation. By analyzing the receiver operating characteristic curve, a PPX dose of 0.375 mg/day was found to be the optimal cut-off value for predicting augmentation. After stratifying patients according to PPX treatment duration, at median treatment duration of 46 months, optimal cut-off values for daily doses were 0.375 and 0.500 mg/day for <46 months and ≥46 months of treatment, respectively. The RLS augmentation with PPX treatment in Japanese patients was occurred at rate of 9.1%, being quite compatible with previously reported rates in Caucasian patients. The symptom could appear within a relatively short period after starting the treatment in possibly vulnerable cases even with a smaller drug dose. Our results support the importance of keeping doses of PPX low throughout the RLS treatment course to prevent augmentation. PMID:28264052

  9. Efficacy of Intravenous Iron Sucrose in Hemodialysis Patients with Restless Legs Syndrome (RLS): A Randomized, Placebo-Controlled Study

    PubMed Central

    Deng, Yinghui; Wu, Jinglin; Jia, Qiang

    2017-01-01

    Background Restless legs syndrome (RLS) is a common disorder in hemodialysis (HD) patients that causes sleep disturbances and diminished quality of life. Because iron deficiency has been implicated in the pathogenesis of RLS, we sought to investigate the effects of intravenous (IV) iron sucrose on symptoms of RLS in HD patients. Material/Methods The study was a randomized, placebo-controlled study of 1000 mg iron sucrose versus normal saline as placebo. Patients were evaluated at baseline and 2 weeks after the last injection. The severity of RLS was assessed using the International RLS Study Group rating scale (IRLS). Blood samples were taken to measure iron parameters reflecting the iron status, including serum ferritin (SF) concentration, percentage transferrin saturation (TSAT%) and hemoglobin (Hb), and other biochemical parameters as safety assessments, including creatinine (Cr), urea, intact parathyroid hormone (iPTH), and the index of urea clearance (Kt/V). Adverse events were monitored in all subjects during the period of infusion. Results After 2 weeks, IRLS scores decreased more in the IV-iron group (−7.38±2.03) than in the placebo group (−0.81±2.61) (P=0.000). Serum ferritin, TSAT, and hemoglobin increased more in the IV-iron group (227.63±77.64 μg/L; 26.06±7.77%; 13.98±3.62g/L, respectively) than in the placebo group (SF, p=0.000; TSAT, p=0.000; Hb, p=0.000, respectively). There were no significant differences between IV-iron and placebo groups in Cr, urea, iPTH, and Kt/V. No adverse effects were observed in the study. Conclusions IV iron sucrose is a safe and effective treatment for reducing RLS symptoms in HD patients over the short-term. PMID:28285317

  10. Physical activity and self-reported symptoms of insomnia, restless legs syndrome, and depression: the comprehensive dialysis study.

    PubMed

    Anand, Shuchi; Johansen, Kirsten L; Grimes, Barbara; Kaysen, George A; Dalrymple, Lorien S; Kutner, Nancy G; Chertow, Glenn M

    2013-01-01

    Symptoms of sleep and mood disturbances are common among patients on dialysis and are associated with significant decrements in survival and health-related quality of life. We used data from the Comprehensive Dialysis Study (CDS) to examine the association of self-reported physical activity with self-reported symptoms of insomnia, restless legs syndrome (RLS), and depression in patients new to dialysis. The CDS collected data on physical activity, functional status, and health-related quality of life from 1678 patients on either peritoneal (n = 169) or hemodialysis (n = 1509). The Human Activity Profile was used to measure self-reported physical activity. Symptoms were elicited in the following manner: insomnia using three questions designed to capture difficulty in initiating or maintaining sleep, RLS using three questions based on the National Institutes of Health workshop, and depression using the two-item Patient Health Questionnaire. We obtained data on symptoms of insomnia and depression for 1636, and on symptoms of RLS for 1622 (>98%) patients. Of these, 863 (53%) reported one of three insomnia symptoms as occurring at a persistent frequency. Symptoms of RLS and depression occurred in 477 (29%) and 451 (28%) of patients, respectively. The Adjusted Activity Score of the Human Activity Profile was inversely correlated with all three conditions in models adjusting for demographics, comorbid conditions, and laboratory variables. Sleep and mood disturbances were commonly reported in our large, diverse cohort of patients new to dialysis. Patients who reported lower levels of physical activity were more likely to report symptoms of insomnia, RLS, and depression.

  11. Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries

    PubMed Central

    Trenkwalder, C; Garcia-Borreguero, D; Montagna, P; Lainey, E; de Weerd, A W; Tidswell, P; Saletu-Zyhlarz, G; Telstad, W; Ferini-Strambi, L

    2004-01-01

    Objective: To assess the efficacy, safety, and tolerability of ropinirole in the treatment of patients with restless legs syndrome. Methods: A 12 week, prospective, double blind, randomised comparison involving 284 patients from 10 European countries. All participants had a score of ⩾15 on the international restless legs scale (IRLS). Patients were randomised (1:1) to receive either ropinirole 0.25–4.0 mg once daily or placebo. The primary efficacy end point was mean change from baseline to week 12 in total IRLS score. Global improvements (clinical global impression (CGI) scale) and improvements in sleep, health related quality of life (QoL; using generic and disease specific measures), work, and other activities were also assessed. Results: 112/146 patients (76.7%) taking ropinirole and 109/138 (79.0%) taking placebo completed the study. Improvement in IRLS at week 12 with ropinirole (mean (SD) dose, 1.90 (1.13) mg/day) was greater than with placebo (mean (SE): -11.04 (0.719) v -8.03 (0.738) points; adjusted difference = -3.01 (95% confidence interval (CI), -5.03 to -0.99); p = 0.0036). More patients in the ropinirole group (53.4%) showed improvement on the CGI scale at week 12 than in the placebo group (40.9%; adjusted odds ratio = 1.7 (1.02 to 2.69); p = 0.0416). Significant differences on both IRLS and CGI scales favouring ropinirole were apparent by week 1. Ropinirole was also associated with significantly greater improvements in sleep and QoL end points. The most common adverse events were nausea and headache. Conclusions: Ropinirole improves restless legs syndrome compared with placebo, with benefits apparent by week 1. It is generally well tolerated. PMID:14707315

  12. HC-HA/PTX3 Purified From Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence of Limbal Epithelial Progenitor/Stem Cells.

    PubMed

    Chen, Szu-Yu; Han, Bo; Zhu, Ying-Ting; Mahabole, Megha; Huang, Jie; Beebe, David C; Tseng, Scheffer C G

    2015-11-01

    To explore how limbal niche cells (LNCs) may control quiescence, self-renewal, and corneal epithelial lineage commitment/differentiation of limbal epithelial progenitor/stem cells (LEPCs), we have established an in vitro sphere assay by reunion between the two cell types in three-dimensional Matrigel. The resultant sphere exhibits inhibition of corneal epithelial lineage commitment/differentiation and marked clonal growth of LEPCs, of which the latter is correlated with activation of canonical Wnt signaling. Herein, we have created a similar reunion assay in immobilized heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3), which is purified from amniotic membrane (AM) and consists of a complex formed by hyaluronic covalently linked to heavy chain 1 of inter-α-inhibitor and noncovalently linked to pentraxin 3. The resultant spheres exhibited similar suppression of corneal epithelial lineage commitment/differentiation but upregulation of quiescence markers including nuclear translocation of Bmi-1, and negligible clonal growth of LEPCs. This outcome was correlated with the suppression of canonical Wnt but activation of noncanonical (Planar cell polarity) Wnt signaling as well as BMP signaling in both LEPCs and LNCs. The activation of BMP signaling in LNCs was pivotal because nuclear translocation of pSmad1/5/8 was prohibited in hLEPCs when reunioned with mLNCs of conditionally deleted Bmpr1a;Acvr1(DCKO) mice. Furthermore, ablation of BMP signaling in LEPCs led to upregulation of cell cycle genes, downregulation of Bmi-1, nuclear exclusion of phosphorylated Bmi-1, and marked promotion of the clonal growth of LEPCs. Hence, HC-HA/PTX3 uniquely upregulates BMP signaling in LNCs which leads to BMP signaling in LEPCs to achieve quiescence, helping explain how AM transplantation is clinically useful to be used as a matrix for ex vivo expansion of LEPCs and to treat corneal blindness caused by limbal stem cells deficiency.

  13. Multiband Studies of the Optical Periodic Modulation in the X-Ray Binary SAX J1808.4-3658 during Its Quiescence and 2008 Outburst

    NASA Astrophysics Data System (ADS)

    Wang, Zhongxiang; Breton, Rene P.; Heinke, Craig O.; Deloye, Christopher J.; Zhong, Jing

    2013-03-01

    We report on time-resolved optical imaging of the X-ray binary SAX J1808.4-3658 during its quiescent state and 2008 outburst. The binary, containing an accretion-powered millisecond pulsar, has a large sinusoidal-like modulation in its quiescent optical emission. We employ a Markov chain Monte Carlo technique to fit our multi-band light curve data in quiescence with an irradiated star model, and derive a tight constraint of 50^{+6}_{-5} deg on the inclination angle i of the binary system. The pulsar and its companion are constrained to have masses of 0.97^{+0.31}_{-0.22} M_{⊙} and 0.04^{+0.02}_{-0.01} M_{⊙} (both 1σ ranges), respectively. The dependence of these results on the measurements of the companion's projected radial velocity is discussed. We also find that the accretion disk had nearly constant optical fluxes over a ~500 day period in the quiescent state our data covered, but started brightening 1.5 months before the 2008 outburst. Variations in modulation during the outburst were detected in our four observations made 7-12 days after the start of the outburst, and a sinusoidal-like modulation with 0.2 mag amplitude changed to have a smaller amplitude of 0.1 mag. The modulation variations are discussed. We estimate the albedo of the companion during its quiescence and the outburst, which was approximately 0 and 0.8 (for isotropic emission), respectively. This large difference probably provides additional evidence that the neutron star in the binary turns on as a radio pulsar in quiescence.

  14. Restless Legs Syndrome/Willis-Ekbom Disease and Periodic Limb Movements: A Comprehensive Review of Epidemiology, Pathophysiology, Diagnosis and Treatment Considerations.

    PubMed

    Pratt, Dyveke P

    2016-01-01

    Restless legs syndrome (RLS) or Willis-Ekbom Disease is a common, but frequently under- recognized and misdiagnosed condition seen in many subspecialty practices including neurology, sleep medicine, primary care and rheumatology. Periodic limb movements are a frequent co-morbid diagnosis in RLS. Despite prior beliefs that the condition was "benign", it has been demonstrated to have a considerable impact on sufferers quality of life, physically and psychologically, as well as socially. This chapter is meant as a comprehensive review of RLS encompassing epidemiology, pathophysiology, diagnosis, and treatment considerations.

  15. Method and system to directly produce electrical power within the lithium blanket region of a magnetically confined, deuterium-tritium (DT) fueled, thermonuclear fusion reactor

    DOEpatents

    Woolley, Robert D.

    1999-01-01

    A method for integrating liquid metal magnetohydrodynamic power generation with fusion blanket technology to produce electrical power from a thermonuclear fusion reactor located within a confining magnetic field and within a toroidal structure. A hot liquid metal flows from a liquid metal blanket region into a pump duct of an electromagnetic pump which moves the liquid metal to a mixer where a gas of predetermined pressure is mixed with the pressurized liquid metal to form a Froth mixture. Electrical power is generated by flowing the Froth mixture between electrodes in a generator duct. When the Froth mixture exits the generator the gas is separated from the liquid metal and both are recycled.

  16. Method and System to Directly Produce Electrical Power within the Lithium Blanket Region of a Magnetically Confined, Deuterium-Tritium (DT) Fueled, Thermonuclear Fusion Reactor

    SciTech Connect

    Woolley, Robert D.

    1998-09-22

    A method for integrating liquid metal magnetohydrodynamic power generation with fusion blanket technology to produce electrical power from a thermonuclear fusion reactor located within a confining magnetic field and within a toroidal structure. A hot liquid metal flows from a liquid metal blanket region into a pump duct of an electromagnetic pump which moves the liquid metal to a mixer where a gas of predetermined pressure is mixed with the pressurized liquid metal to form a Froth mixture. Electrical power is generated by flowing the Froth mixture between electrodes in a generator duct. When the Froth mixture exits the generator the gas is separated from the liquid metal and both are recycled.

  17. Preparation and characterization of carbons for the retention of halogens in the condenser vacuum system of a thermonuclear plant

    NASA Astrophysics Data System (ADS)

    Román, S.; González, J. F.; Gañán, J.; Sabio, E.; González-García, C. M.; Ramiro, A.; Mangut, V.

    2006-06-01

    Activated carbons were prepared by air and carbon dioxide activation, from almond tree pruning, with the aim of obtaining carbons that reproduce the textural and mechanical properties of the carbons currently used in the filtering system of the condenser vacuum installation of a Thermonuclear Plant (CNA; Central Nuclear de Almaraz in Caceres, Spain), produced from coconut shell. The variables studied in non-catalytic gasification series with air were the temperature (215-270 °C) and the time (1-16 h) and the influence of the addition of one catalyst (Co) and the time (1-2 h) in catalytic gasification. In the case of activation with CO 2, the influence of the temperature (700-950 °C) and the time (1-8 h) was studied. The resulting carbons were characterized in terms of their BET surface, porosity, and pore size distribution. The N 2 adsorption isotherms at 77 K for both series showed a type I behaviour, typical of microporous materials. The isotherms showed that with both gasificant agents the temperature rise produced an increase in the carbon porosity. With regards to the activation time, a positive effect on the N 2 adsorbed volume on the carbons was observed. The best carbons of each series, as well as the CNA (carbon currently used in the CNA), were characterized by mercury porosimetry and iodine solution adsorption isotherms. The results obtained allowed to state that several of the carbons produced had characteristics similar to the carbon that is target of reproduction (which has SBET of 741 m 2 g -1, Vmi of 0.39 cm 3 g -1 and a iodine retention capacity of 429.3 mg g -1): carbon C (gasification with CO 2 at 850 °C during 1 h), with SBET of 523 m 2 g -1, Vmi of 0.33 cm 3 g -1 and a iodine retention capacity of 402.5 mg g -1, and carbon D (gasification with CO 2 at 900 °C during 1 h), whose SBET is 672 m 2 g -1, Vmi is 0.28 cm 3 g -1 and has a iodine retention capacity of 345.2 mg g -1.

  18. The quintessence of quiescence.

    PubMed

    Yabut, Odessa; Pleasure, Samuel J

    2014-05-07

    Neurogenic niches in the adult mammalian brain are composed of heterogeneous populations of neural stem cells. In this issue of Neuron, Codega et al. (2014) isolate quiescent neural stem cells from the adult subventricular zone and demonstrate their stem cell characteristics.

  19. An HST COS and Archival IUE Far UV Analysis of the U Geminorum-Type Dwarf Nova CW MonocerotisDuring Quiescence

    NASA Astrophysics Data System (ADS)

    Hause, Connor; Sion, Edward M.; Godon, Patrick

    2016-01-01

    CW Mon is a U Geminorum-type dwarf nova with an orbital period of 0.1766 days, which displays both wide and narrow outbursts with a recurrence time between outbursts of 150 days. Szkody and Mateo (1986) found evidence for a grazing eclipse of the accretion disk, an orbital inclination of 67 degrees and a distance of 280 pc while Kato et al.(2003) obtained = 210 pc. We de-reddened the data with E(B-V) = 0.06 (Bruch and Engel 1993). We present a synthetic spectral analysis of two archival IUE spectra and our recent HST COS spectrum (Pala et al. 2015) taken during quiescence as part of a study to detect the underlying accreting white dwarfs in dwarf novae and nova-like variables. Our model photosphere grid and optically thick accretion disk model grid were constructed with the latest versions of Tlusty, Synspec and Disksyn. The results of our analysis indicate the presence of a relatively cool white dwarf (~ 20,000K) and a low accretion rate (~ 10^-10 Msun/yr or lower) to yield a distance in agreement with the observed distance range of 210 to 280 pc. Our findings will be compared with the properties of the hot components during the quiescences of other dwarf novae above the period gap with long recurrence times.This work was supported by NASA/HST grant GO-12870.01A to Villanova University

  20. Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population

    PubMed Central

    Jiménez-Jiménez, Félix Javier; García-Martín, Elena; Alonso-Navarro, Hortensia; Martínez, Carmen; Zurdo, Martín; Turpín-Fenoll, Laura; Millán-Pascual, Jorge; Adeva-Bartolomé, Teresa; Cubo, Esther; Navacerrada, Francisco; Rojo-Sebastián, Ana; Rubio, Lluisa; Ortega-Cubero, Sara; Pastor, Pau; Calleja, Marisol; Plaza-Nieto, José Francisco; Pilo-De-La-Fuente, Belén; Arroyo-Solera, Margarita; García-Albea, Esteban; Agúndez, José A.G.

    2015-01-01

    Abstract Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS. We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay. The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively). Restless legs syndrome patients carrying the allelic variant rs731236G had an earlier age at onset, and those carrying the rs731236GG genotype had higher severity of RLS, although these data disappeared after multivariate analyses. None of the SNPs studied was related with the positivity of family history of RLS. These results suggest a modest, but significant association between VDR rs731236 SNP and the risk for RLS. PMID:26632733

  1. An Improved Reaction Rate Formulation for Charged-Particle Induced Thermonuclear Reaction of {sup 2}H(d,{gamma}){sup 4}He

    SciTech Connect

    Aziz, Azni Abdul; Yusof, Norhasliza; Idris, Mahirah; Kassim, Hasan Abu

    2011-03-30

    The reaction rate formula utilized in compilations such as the Nuclear Astrophysics Compilation of Reaction Rates (NACRE) uses low energy approximation due to temperatures in stars are in the region of a few keVs. Most nuclear reaction experiments were done in MeV range and the interior temperatures of massive stars are {approx}10{sup 9} K. Hence an improved formulation for calculating the nuclear reaction rate that is applicable to high temperatures is discussed in this work. The exact tunneling probability that is applicable for all energies is obtained by solving the Schroedinger equation. This yields an enhanced expression for the astrophysical S-factor for calculating the thermonuclear reaction rate at high temperature. The thermonuclear reaction rate from this work is applied to the {sup 2}H(d,{gamma}){sup 4}He reaction and is compared with the NACRE compilation. This improved reaction rate can be included in the nuclear reaction network in a Big Bang nucleosynthesis (BBN) code or a stellar nuclear network code.

  2. SYSTEMATIC UNCERTAINTIES IN THE SPECTROSCOPIC MEASUREMENTS OF NEUTRON-STAR MASSES AND RADII FROM THERMONUCLEAR X-RAY BURSTS. II. EDDINGTON LIMIT

    SciTech Connect

    Guever, Tolga; Oezel, Feryal; Psaltis, Dimitrios

    2012-03-01

    Time-resolved X-ray spectroscopy of thermonuclear bursts observed from low-mass X-ray binaries offer a unique tool to measure neutron-star masses and radii. In this paper, we continue our systematic analysis of all the X-ray bursts observed with Rossi X-ray Timing Explorer from X-ray binaries. We determine the events that show clear evidence for photospheric radius expansion and measure the Eddington limits for these accreting neutron stars using the bolometric fluxes attained at the touchdown moments of each X-ray burst. We employ a Bayesian technique to investigate the degree to which the Eddington limit for each source remains constant between bursts. We find that for sources with a large number of radius expansion bursts, systematic uncertainties are at a 5%-10% level. Moreover, in six sources with only pairs of Eddington-limited bursts, the distribution of fluxes is consistent with a {approx}10% fractional dispersion. This indicates that the spectroscopic measurements of neutron-star masses and radii using thermonuclear X-ray bursts can reach the level of accuracy required to distinguish between different neutron-star equations of state, provided that uncertainties related to the overall flux calibration of X-ray detectors are of comparable magnitude.

  3. The LOFT perspective on neutron star thermonuclear bursts: White paper in support of the mission concept of the large observatory for X-ray timing

    SciTech Connect

    in't Zand, J. J.M.; Malone, Christopher M.; Altamirano, D.; Ballantyne, D. R.; Bhattacharyya, S.; Brown, E. F.; Cavecchi, Y.; Chakrabarty, D.; Chenevez, J.; Cumming, A.; Degenaar, N.; Falanga, M.; Galloway, D. K.; Heger, A.; Jose, J.; Keek, L.; Linares, M.; Mahmoodifar, S.; Mendez, M.; Miller, M. C.; Paerels, F. B. S.; Poutanen, J.; Rozanska, A.; Schatz, H.; Serino, M.; Strohmayer, T. E.; Suleimanov, V. F.; Thielemann, F. -K.; Watts, A. L.; Weinberg, N. N.; Woosley, S. E.; Yu, W.; Zhang, S.; Zingale, M.

    2015-01-14

    The Large Area Detector (LAD) on the Large Observatory For X-ray Timing ( LOFT ), with a 8.5 m 2 photon- collecting area in the 2–30 keV bandpass at CCD-class spectral resolving power (λ/Δλ = 10 – 100), is designed for optimum performance on bright X-ray sources. Thus, it is well-suited to study thermonuclear X-ray bursts from Galactic neutron stars. These bursts will typically yield 2 x 105 photon detections per second in the LAD, which is at least 15 times more than with any other instrument past, current or anticipated. The Wide Field Monitor (WFM) foreseen for LOFT uniquely combines 2–50 keV imaging with large (30%) prompt sky coverage. This will enable the detection of tens of thousands of thermonuclear X-ray bursts during a 3-yr mission, including tens of superbursts. Both numbers are similar or more than the current database gathered in 50 years of X-ray astronomy.

  4. Results from the MARBLE Campaign on the National Ignition Facility: Implosion of Foam-Filled Capsules for Studying Thermonuclear Burn in the Presence of Heterogeneous Mix

    NASA Astrophysics Data System (ADS)

    Murphy, T. J.; Douglas, M. R.; Cardenas, T.; Devolder, B. G.; Fincke, J. R.; Gunderson, M. A.; Haines, B. M.; Hamilton, C. E.; Kim, Y. H.; Lee, M. N.; Oertel, J. A.; Olson, R. E.; Randolph, R. B.; Shah, R. C.; Smidt, J. M.

    2016-10-01

    The MARBLE campaign on NIF investigates the effect of heterogeneous mix on thermonuclear burn for comparison to a probability distribution function (PDF) burn model. MARBLE utilizes plastic capsules filled with deuterated plastic foam and tritium gas. The ratio of DT to DD neutron yield is indicative of the degree to which the foam and the gas atomically mix. Platform development experiments have been performed to understand the behavior of the foam and of the gas separately using two types of capsule. The first uses partially deuterated foam and hydrogen gas fill to understand the burn in the foam. The second uses undeuterated foam and deuterium gas fill to understand the dynamics of the gas. Experiments using deuterated foam and tritium gas are planned. Results of these experiments, and the implications for our understanding of thermonuclear burn in heterogeneously mixed separated reactant experiments will be discussed. This work is supported by US DOE/NNSA, performed at LANL, operated by LANS LLC under contract DE-AC52-06NA25396.

  5. On the implementation of a chain nuclear reaction of thermonuclear fusion on the basis of the p+{sup 11}B process

    SciTech Connect

    Belyaev, V. S.; Krainov, V. P.; Zagreev, B. V.; Matafonov, A. P.

    2015-07-15

    Various theoretical and experimental schemes for implementing a thermonuclear reactor on the basis of the p+{sup 11}B reaction are considered. They include beam collisions, fusion in degenerate plasmas, ignition upon plasma acceleration by ponderomotive forces, and the irradiation of a solid-state target from {sup 11}B with a proton beam under conditions of a Coulomb explosion of hydrogen microdrops. The possibility of employing ultra-short high-intensity laser pulses to initiate the p+{sup 11}B reaction under conditions far from thermodynamic equilibrium is discussed. This and some other weakly radioactive thermonuclear reactions are promising owing to their ecological cleanness—there are virtually no neutrons among fusion products. Nuclear reactions that follow the p+{sup 11}B reaction may generate high-energy protons, sustaining a chain reaction, and this is an advantage of the p+{sup 11}B option. The approach used also makes it possible to study nuclear reactions under conditions close to those in the early Universe or in the interior of stars.

  6. Numerical models for ground deformation and gravity changes during volcanic unrest: simulating the hydrothermal system dynamics of a restless caldera

    NASA Astrophysics Data System (ADS)

    Coco, A.; Gottsmann, J.; Whitaker, F.; Rust, A.; Currenti, G.; Jasim, A.; Bunney, S.

    2016-04-01

    Ground deformation and gravity changes in restless calderas during periods of unrest can signal an impending eruption and thus must be correctly interpreted for hazard evaluation. It is critical to differentiate variation of geophysical observables related to volume and pressure changes induced by magma migration from shallow hydrothermal activity associated with hot fluids of magmatic origin rising from depth. In this paper we present a numerical model to evaluate the thermo-poroelastic response of the hydrothermal system in a caldera setting by simulating pore pressure and thermal expansion associated with deep injection of hot fluids (water and carbon dioxide). Hydrothermal fluid circulation is simulated using TOUGH2, a multicomponent multiphase simulator of fluid flows in porous media. Changes in pore pressure and temperature are then evaluated and fed into a thermo-poroelastic model (one-way coupling), which is based on a finite-difference numerical method designed for axi-symmetric problems in unbounded domains.

    Informed by constraints available for the Campi Flegrei caldera (Italy), a series of simulations assess the influence of fluid injection rates and mechanical properties on the hydrothermal system, uplift and gravity. Heterogeneities in hydrological and mechanical properties associated with the presence of ring faults are a key determinant of the fluid flow pattern and consequently the geophysical observables. Peaks (in absolute value) of uplift and gravity change profiles computed at the ground surface are located close to injection points (namely at the centre of the model and fault areas). Temporal evolution of the ground deformation indicates that the contribution of thermal effects to the total uplift is almost negligible with respect to the pore pressure contribution during the first years of the unrest, but increases in time and becomes dominant after a long period of the simulation. After a transient increase over the first years of

  7. Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse

    PubMed Central

    Corvaisier, Matthieu; Bauzone, Marjolaine; Corfiotti, François; Renaud, Florence; Amrani, Mehdi El; Monté, Didier; Truant, Stéphanie; Leteurtre, Emmanuelle; Formstecher, Pierre; Van Seuningen, Isabelle

    2016-01-01

    Our aim was to decipher the role and clinical relevance of the YAP/TAZ transcriptional coactivators in the regulation of the proliferation/quiescence balance in human colon cancer cells (CCC) and survival after 5FU-based chemotherapy. The prognostic value of YAP/TAZ on tumor relapse and overall survival was assessed in a five-year follow-up study using specimens of liver metastases (n = 70) from colon cancer patients. In 5FU-chemoresistant HT29-5F31 and -chemosensitive HCT116 and RKO CCC, a reversible G0 quiescent state mediated by Cyclin E1 down-regulation was induced by 5FU in 5F31 cells and recapitulated in CCC by either YAP/TAZ or Cyclin E1 siRNAs or the YAP inhibitor Verteporfin. Conversely, the constitutive active YAPdc-S127A mutant restricted cellular quiescence in 5FU-treated 5F31 cells and sustained high Cyclin E1 levels through CREB Ser-133 phosphorylation and activation. In colon cancer patients, high YAP/TAZ level in residual liver metastases correlated with the proliferation marker Ki-67 (p < 0.0001), high level of the YAP target CTGF (p = 0.01), shorter disease-free and overall survival (p = 0.008 and 0.04, respectively). By multivariate analysis and Cox regression model, the YAP/TAZ level was an independent factor of overall (Hazard ratio [CI 95%] 2.06 (1.02–4.16) p = 0.045) and disease-free survival (Hazard ratio [CI 95%] 1.98 (1.01–3.86) p = 0.045). Thus, YAP/ TAZ pathways contribute to the proliferation/quiescence switch during 5FU treatment according to the concerted regulation of Cyclin E1 and CREB. These findings provide a rationale for therapeutic interventions targeting these transcriptional regulators in patients with residual chemoresistant liver metastases expressing high YAP/TAZ levels. PMID:27527859

  8. The 2015 Decay of the Black Hole X-Ray Binary V404 Cygni: Robust Disk-jet Coupling and a Sharp Transition into Quiescence

    NASA Astrophysics Data System (ADS)

    Plotkin, R. M.; Miller-Jones, J. C. A.; Gallo, E.; Jonker, P. G.; Homan, J.; Tomsick, J. A.; Kaaret, P.; Russell, D. M.; Heinz, S.; Hodges-Kluck, E. J.; Markoff, S.; Sivakoff, G. R.; Altamirano, D.; Neilsen, J.

    2017-01-01

    We present simultaneous X-ray and radio observations of the black hole X-ray binary V404 Cygni at the end of its 2015 outburst. From 2015 July 11–August 5, we monitored V404 Cygni with Chandra, Swift, and NuSTAR in the X-ray, and with the Karl G. Jansky Very Large Array and the Very Long Baseline Array in the radio, spanning a range of luminosities that were poorly covered during its previous outburst in 1989 (our 2015 campaign covers 2× {10}33≲ {L}{{X}}≲ {10}34 {erg} {{{s}}}-1). During our 2015 campaign, the X-ray spectrum evolved rapidly from a hard photon index of {{Γ }}≈ 1.6 (at {L}{{X}}≈ {10}34 {erg} {{{s}}}-1) to a softer {{Γ }}≈ 2 (at {L}{{X}}≈ 3× {10}33 {erg} {{{s}}}-1). We argue that V404 Cygni reaching {{Γ }}≈ 2 marks the beginning of the quiescent spectral state, which occurs at a factor of ≈3–4 higher X-ray luminosity than the average pre-outburst luminosity of ≈ 8× {10}32 {erg} {{{s}}}-1. V404 Cygni falls along the same radio/X-ray luminosity correlation that it followed during its previous outburst in 1989, implying a robust disk-jet coupling. We exclude the possibility that a synchrotron-cooled jet dominates the X-ray emission in quiescence, leaving synchrotron self-Compton from either a hot accretion flow or from a radiatively cooled jet as the most likely sources of X-ray radiation, and/or particle acceleration along the jet becoming less efficient in quiescence. Finally, we present the first indications of correlated radio and X-ray variability on minute timescales in quiescence, tentatively measuring the radio emission to lag the X-ray by 15+/- 4 minute, suggestive of X-ray variations propagating down a jet with a length of <3.0 au.

  9. Comparison of haloperidol and midazolam in restless management of patients referred to the Emergency Department: A double-blinded, randomized clinical trial

    PubMed Central

    Esmailian, Mehrdad; Ahmadi, Omid; Taheri, Mehrsa; Zamani, Majid

    2015-01-01

    Background: Restless and violent behaviors are common in Emergency Departments (EDs), which need therapeutic interventions in most of the times. The first-generation anti-psychotic drugs are one of the most applicable therapeutic agents in the management of such patients, but their use has some limitations. Some studies suggest midazolam as an alternative medicine. Therefore, this study was performed with the aim of comparison of the efficacy and safety of haloperidol and midazolam in the restless management of referring patients to EDs. Materials and Methods: The present double-blinded trial was done on patients needed sedation and referred to the ED of Alzahra Hospital, Isfahan, Iran, in 2014. The patients were categorized into two random groups of haloperidol (5 mg) and midazolam receivers (2.5 mg for those weighing <50 kg and 5 mg in >50 kg), as intramuscular administration. The time to achieve sedation, need for rescue dose, need to resedation within the first 60 min, and adverse effects of drugs were compared among the groups. Results: Forty-eight patients were entered to the study. The mean age in the haloperidol and midazolam groups was 44.8 ± 4.1 years and 45.5 ± 4.7 years, respectively (P = 0.91). The mean time of sedation in the haloperidol and midazolam groups was 5.6 ± 0.3 min and 5.2 ± 0.1 min, respectively (P = 0.31). The mean time of full consciousness after sedation was 36.2 ± 4.5 min and 38.2 ± 3.4 min in the haloperidol and midazolam groups, respectively (P = 0.72). On average, time to arousal in the midazolam group was 10.33 min more than the haloperidol group, but it was not statistically significant. Conclusion: The results of the present study show that administration of midazolam and haloperidol have similar efficacy in the treatment of restless symptoms with the same recovery time from drug effects for referring patients to the ED. In addition, none of the adverse effects were observed in this study. PMID:26759570

  10. The Restless Mind

    ERIC Educational Resources Information Center

    Smallwood, Jonathan; Schooler, Jonathan W.

    2006-01-01

    This article reviews the hypothesis that mind wandering can be integrated into executive models of attention. Evidence suggests that mind wandering shares many similarities with traditional notions of executive control. When mind wandering occurs, the executive components of attention appear to shift away from the primary task, leading to failures…

  11. David Gale: Restless Pioneer

    ERIC Educational Resources Information Center

    Meyer, Walter

    2006-01-01

    David Gale was one of the mathematicians responsible for the modern form of the theory of duality in linear programming and the associated proof of the minimax theorem in the theory of games. He is a member of the National Academy of Sciences and is Professor Emeritus of Mathematics and Operations Research at the University of California at…

  12. Restless Legs Syndrome

    MedlinePlus

    ... Basics Sports Safety Injury Rehabilitation Emotional Well-Being Mental Health Sex and Birth Control Sex and Sexuality Birth ... Basics Sports Safety Injury Rehabilitation Emotional Well-Being Mental Health Sex and Birth Control Sex and Sexuality Birth ...

  13. Restless Legs Syndrome

    MedlinePlus

    ... brain’s basal ganglia circuits that use the neurotransmitter dopamine, which is needed to produce smooth, purposeful muscle ... Parkinson’s disease, another disorder of the basal ganglia’s dopamine pathways, often have RLS as well. RLS also ...

  14. Restless Legs Syndrome

    MedlinePlus

    ... due to an imbalance of the brain chemical dopamine, which sends messages to control muscle movement. Heredity ... in your legs. These include: Medications that increase dopamine in the brain. These medications reduce motion in ...

  15. Restless legs syndrome

    MedlinePlus

    ... chap 410. Read More Drowsiness Numbness and tingling Review Date 8/13/2015 Updated by: Joseph V. ... Division of Neurology, Cooper University Hospital, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by ...

  16. Restless Legs Syndrome Foundation

    MedlinePlus

    ... is a registered 501(c)3 non-profit corporation (Tax ID #56-1784846). Donations are tax-deductible ... is a registered 501(c)3 non-profit corporation (Tax ID #56-1784846). Donations are tax-deductible ...

  17. Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle.

    PubMed

    Bigot, Anne; Duddy, William J; Ouandaogo, Zamalou G; Negroni, Elisa; Mariot, Virginie; Ghimbovschi, Svetlana; Harmon, Brennan; Wielgosik, Aurore; Loiseau, Camille; Devaney, Joe; Dumonceaux, Julie; Butler-Browne, Gillian; Mouly, Vincent; Duguez, Stéphanie

    2015-11-10

    The molecular mechanisms by which aging affects stem cell number and function are poorly understood. Murine data have implicated cellular senescence in the loss of muscle stem cells with aging. Here, using human cells and by carrying out experiments within a strictly pre-senescent division count, we demonstrate an impaired capacity for stem cell self-renewal in elderly muscle. We link aging to an increased methylation of the SPRY1 gene, a known regulator of muscle stem cell quiescence. Replenishment of the reserve cell pool was modulated experimentally by demethylation or siRNA knockdown of SPRY1. We propose that suppression of SPRY1 by age-associated methylation in humans inhibits the replenishment of the muscle stem cell pool, contributing to a decreased regenerative response in old age. We further show that aging does not affect muscle stem cell senescence in humans.

  18. Predicting Quiescence: The Dependence of Specific Star Formation Rate on Galaxy Size and Central Density at 0.5 < z < 2.5

    NASA Astrophysics Data System (ADS)

    Whitaker, Katherine E.; Bezanson, Rachel; van Dokkum, Pieter G.; Franx, Marijn; van der Wel, Arjen; Brammer, Gabriel; Förster-Schreiber, Natascha M.; Giavalisco, Mauro; Labbé, Ivo; Momcheva, Ivelina G.; Nelson, Erica J.; Skelton, Rosalind

    2017-03-01

    In this paper, we investigate the relationship between star formation and structure, using a mass-complete sample of 27,893 galaxies at 0.5 < z < 2.5 selected from 3D-HST. We confirm that star-forming galaxies are larger than quiescent galaxies at fixed stellar mass ({M}\\star ). However, in contrast with some simulations, there is only a weak relation between star formation rate (SFR) and size within the star-forming population: when dividing into quartiles based on residual offsets in SFR, we find that the sizes of star-forming galaxies in the lowest quartile are 0.27 ± 0.06 dex smaller than the highest quartile. We show that 50% of star formation in galaxies at fixed {M}\\star takes place within a narrow range of sizes (0.26 dex). Taken together, these results suggest that there is an abrupt cessation of star formation after galaxies attain particular structural properties. Confirming earlier results, we find that central stellar density within a 1 kpc fixed physical radius is the key parameter connecting galaxy morphology and star formation histories: galaxies with high central densities are red and have increasingly lower SFR/{M}\\star , whereas galaxies with low central densities are blue and have a roughly constant (higher) SFR/{M}\\star at a given redshift. We find remarkably little scatter in the average trends and a strong evolution of >0.5 dex in the central density threshold correlated with quiescence from z ∼ 0.7–2.0. Neither a compact size nor high-n are sufficient to assess the likelihood of quiescence for the average galaxy; instead, the combination of these two parameters together with {M}\\star results in a unique quenching threshold in central density/velocity.

  19. The Accretion Disk and White Dwarf in the Short-Period Dwarf Novae TY Piscium and V436 Centauri during Quiescence

    NASA Astrophysics Data System (ADS)

    Nadalin, Ira; Sion, Edward M.

    2001-07-01

    The short-period dwarf novae TY Psc and V436 Cen are SU UMa systems with very similar orbital periods, similar recurrence times for normal outbursts (~23 days) and superoutbursts (~340 days), and nearly identical outburst amplitudes. We have carried out high-gravity model atmosphere and accretion disk synthetic spectra from the grid of Wade & Hubeny. The best-fit stellar model spectrum, from spectral slope and line fitting, is a white dwarf photosphere having Teff=25,000 K, logg=8, and essentially solar chemical abundances, while the best-fit optically thick accretion disk model, from spectral slope fitting, has Mwd=0.55 Msolar, M=10-9.5 Msolar yr-1, and an inclination i=18deg. The implied accretion rate is almost certainly too large for dwarf nova quiescence. The predicted fluxes using parameters from the photosphere and disk spectral slope fitting models reveal enormous differences compared with the observed luminosity using a reasonable distance estimate. For TY Psc, the predicted accretion disk luminosity is ~100 times too luminous, while the stellar luminosity is too luminous by a factor of ~10. For V436 Cen, the best-fit high-gravity model photosphere, from spectral slope fitting, yields Teff=24,000 K, logg=8, and essentially solar abundance, while the best-fit accretion disk models, from spectral slope fitting, yield Mwd=0.8 Msolar, M=10-10 Msolar yr-1, and i=75deg. The presence of broad absorption troughs at unusual wavelength positions suggests the presence of an absorption curtain (upper disk atmosphere) in V436 Cen. The temperatures we have for TY Psc and V436 Cen are higher than normal for the accreting white dwarfs in dwarf novae below the period gap. This could indicate that the systems were not in the deepest level of quiescence when they were observed.

  20. The black hole candidate XTE J1752-223 towards and in quiescence: optical and simultaneous X-ray-radio observations

    NASA Astrophysics Data System (ADS)

    Ratti, E. M.; Jonker, P. G.; Miller-Jones, J. C. A.; Torres, M. A. P.; Homan, J.; Markoff, S.; Tomsick, J. A.; Kaaret, P.; Wijnands, R.; Gallo, E.; Özel, F.; Steeghs, D. T. H.; Fender, R. P.

    2012-07-01

    We present optical, X-ray and radio observations of the black hole transient (BHT) XTE J1752-223 towards and in quiescence. Optical photometry shows that the quiescent magnitude of XTE J1752-223 is fainter than 24.4 mag in the i' band. A comparison with measurements of the source during its 2009-2010 outburst shows that the outburst amplitude is more than 8 mag in the i' band. Known X-ray properties of the source combined with the faintness of the quiescence optical counterpart and the large outburst optical amplitude point towards a short orbital-period system (Porb≲ 6.8 h) with an M type (or later) mass donor, at a distance of 3.5 ≲d≲ 8 kpc. Simultaneous X-ray and radio data were collected with Chandra and the Expanded Very Large Array (EVLA), allowing constraints to be placed on the quiescent X-ray and radio flux of XTE J1752-223. Furthermore, using data covering the final stage of the outburst decay, we investigated the low-luminosity end of the X-ray-radio correlation for this source and compared it with other BHTs. We found that XTE J1752-223 adds to the number of outliers with respect to the 'standard' X-ray-radio luminosity relation. Furthermore, XTE J1752-223 is the second source, after the BHT H1743-322, that shows a transition from the region of the outliers towards the 'standard' correlation at low luminosity. Finally, we report on a faint, variable X-ray source we discovered with Chandra at an angular distance of ˜2.9 arcsec to XTE J1752-223 and at a position angle consistent with that of the radio jets previously observed from the BHT. We discuss the possibility that we detected X-ray emission associated with a jet from XTE J1752-223.

  1. NACRE II: an update of the NACRE compilation of charged-particle-induced thermonuclear reaction rates for nuclei with mass number A<16

    NASA Astrophysics Data System (ADS)

    Xu, Y.; Takahashi, K.; Goriely, S.; Arnould, M.; Ohta, M.; Utsunomiya, H.

    2013-11-01

    An update of the NACRE compilation [3] is presented. This new compilation, referred to as NACRE II, reports thermonuclear reaction rates for 34 charged-particle induced, two-body exoergic reactions on nuclides with mass number A<16, of which fifteen are particle-transfer reactions and the rest radiative capture reactions. When compared with NACRE, NACRE II features in particular (1) the addition to the experimental data collected in NACRE of those reported later, preferentially in the major journals of the field by early 2013, and (2) the adoption of potential models as the primary tool for extrapolation to very low energies of astrophysical S-factors, with a systematic evaluation of uncertainties.

  2. Increased prevalence of restless legs syndrome in patients with acromegaly and effects on quality of life assessed by Acro-QoL.

    PubMed

    Cannavò, S; Condurso, R; Ragonese, M; Ferraù, F; Alibrandi, A; Aricò, I; Romanello, G; Squadrito, S; Trimarchi, F; Silvestri, R

    2011-12-01

    Restless legs syndrome (RLS), a neurological sensory-motor disorder characterized by a compelling urge to move the limbs during the night, is a sleep disturbance that impairs quality of life. Prevalence of RLS and consequences on quality of life were investigated in acromegalic patients. Fifty-six patients (20 men, 55.0 ± 1.6 years), 22 with active acromegaly (group 1) and 34 with controlled disease (group 2), and 95 controls (35 men, 52.9 ± 1.1 years) were evaluated by a structured sleep interview concerning insomnia, circadian sleep disorders and excessive diurnal sleepiness (EDS). The Epworth Sleepiness Scale (ESS) questionnaire was administered to those reporting EDS. Patients were investigated by RLS diagnostic interview and International Restless Leg Syndrome-Rating Scale (IRLS-RS). Quality of life was investigated by AcroQoL questionnaire. RLS was diagnosed in 21% of acromegalics and in 4% of controls (P < 0.002). Prevalence of RLS and mean IRLS-RS was higher in group 1 than in group 2 (P < 0.05). Prevalence of insomnia (P < 0.0002) and of EDS (P < 0.05) and mean ESS score (P < 0.01) were higher in RLS-positive than in RLS-free acromegalics. Video-PSG showed that mean sleep latency (P < 0.01), micro-arousal index (P < 0.05) and wakefulness after sleep onset (P < 0.01) were higher, whereas sleep efficiency (P < 0.01) was lower, in RLS-positive than in RLS-free patients. Global and physical AcroQoL scores were significantly lower in RLS-positive than in RLS-free acromegalics (P < 0.01 and P < 0.001, respectively). Prevalence and severity of RLS is increased in patients with active acromegaly and impacts negatively on their physical performances, dramatically impairing quality of life.

  3. Daily multiwavelength Swift monitoring of the neutron star low-mass X-ray binary Cen X-4: evidence for accretion and reprocessing during quiescence

    NASA Astrophysics Data System (ADS)

    Bernardini, F.; Cackett, E. M.; Brown, E. F.; D'Angelo, C.; Degenaar, N.; Miller, J. M.; Reynolds, M.; Wijnands, R.

    2013-12-01

    We conducted the first long-term (60 d), multiwavelength (optical, ultraviolet, UV, and X-ray) simultaneous monitoring of Cen X-4 with daily Swift observations from 2012 June to August, with the goal of understanding variability in the low-mass X-ray binary Cen X-4 during quiescence. We found Cen X-4 to be highly variable in all energy bands on time-scales from days to months, with the strongest quiescent variability a factor of 22 drop in the X-ray count rate in only 4 d. The X-ray, UV and optical (V band) emission are correlated on time-scales down to less than 110 s. The shape of the correlation is a power law with index γ about 0.2-0.6. The X-ray spectrum is well fitted by a hydrogen neutron star (NS) atmosphere (kT = 59-80 eV) and a power law (with spectral index Γ = 1.4-2.0), with the spectral shape remaining constant as the flux varies. Both components vary in tandem, with each responsible for about 50 per cent of the total X-ray flux, implying that they are physically linked. We conclude that the X-rays are likely generated by matter accreting down to the NS surface. Moreover, based on the short time-scale of the correlation, we also unambiguously demonstrate that the UV emission cannot be due to either thermal emission from the stream impact point, or a standard optically thick, geometrically thin disc. The spectral energy distribution shows a small UV emitting region, too hot to arise from the accretion disc, that we identified as a hotspot on the companion star. Therefore, the UV emission is most likely produced by reprocessing from the companion star, indeed the vertical size of the disc is small and can only reprocess a marginal fraction of the X-ray emission. We also found the accretion disc in quiescence to likely be UV faint, with a minimal contribution to the whole UV flux.

  4. On the Optical-X-Ray Correlation from Outburst to Quiescence in Low-mass X-Ray Binaries: The Representative Cases of V404 Cyg and Cen X-4

    NASA Astrophysics Data System (ADS)

    Bernardini, F.; Russell, D. M.; Kolojonen, K. I. I.; Stella, L.; Hynes, R. I.; Corbel, S.

    2016-08-01

    Low-mass X-ray binaries (LMXBs) show evidence of a global correlation of debated origin between X-ray and optical luminosity. We study for the first time this correlation in two transient LMXBs, the black hole (BH) V404 Cyg and the neutron star Cen X-4, over six orders of magnitude in X-ray luminosity, from outburst to quiescence. After subtracting the contribution from the companion star, the Cen X-4 data can be described by a single power-law correlation of the form {L}{opt}\\propto {L}{{X}}0.44, consistent with disk reprocessing. We find a similar correlation slope for V404 Cyg in quiescence (0.46) and a steeper one (0.56) in the outburst hard state of 1989. However, V404 Cyg is about 160-280 times optically brighter, at a given 3-9 keV X-ray luminosity, compared to Cen X-4. This ratio is a factor of 10 smaller in quiescence, where the normalization of the V404 Cyg correlation also changes. Once the bolometric X-ray emission is considered and the known main differences between V404 Cyg and Cen X-4 are taken into account (a larger compact object mass, accretion disk size, and the presence of a strong jet contribution in the hard state for the BH system), the two systems lie on the same correlation. In V404 Cyg, the jet dominates spectrally at optical-infrared frequencies during the hard state but makes a negligible contribution in quiescence, which may account for the change in its correlation slope and normalization. These results provide a benchmark to compare with data from the 2015 outburst of V404 Cyg and, potentially, other transient LMXBs as well.

  5. A loss-of-function mutation in the PAS kinase Rim15p is related to defective quiescence entry and high fermentation rates of Saccharomyces cerevisiae sake yeast strains.

    PubMed

    Watanabe, Daisuke; Araki, Yuya; Zhou, Yan; Maeya, Naoki; Akao, Takeshi; Shimoi, Hitoshi

    2012-06-01

    Sake yeast cells have defective entry into the quiescent state, allowing them to sustain high fermentation rates. To reveal the underlying mechanism, we investigated the PAS kinase Rim15p, which orchestrates initiation of the quiescence program in Saccharomyces cerevisiae. We found that Rim15p is truncated at the carboxyl terminus in modern sake yeast strains as a result of a frameshift mutation. Introduction of this mutation or deletion of the full-length RIM15 gene in a laboratory strain led to a defective stress response, decreased synthesis of the storage carbohydrates trehalose and glycogen, and impaired G(1) arrest, which together closely resemble the characteristic phenotypes of sake yeast. Notably, expression of a functional RIM15 gene in a modern sake strain suppressed all of these phenotypes, demonstrating that dysfunction of Rim15p prevents sake yeast cells from entering quiescence. Moreover, loss of Rim15p or its downstream targets Igo1p and Igo2p remarkably improved the fermentation rate in a laboratory strain. This finding verified that Rim15p-mediated entry into quiescence plays pivotal roles in the inhibition of ethanol fermentation. Taken together, our results suggest that the loss-of-function mutation in the RIM15 gene may be the key genetic determinant of the increased ethanol production rates in modern sake yeast strains.

  6. A Loss-of-Function Mutation in the PAS Kinase Rim15p Is Related to Defective Quiescence Entry and High Fermentation Rates of Saccharomyces cerevisiae Sake Yeast Strains

    PubMed Central

    Watanabe, Daisuke; Araki, Yuya; Zhou, Yan; Maeya, Naoki; Akao, Takeshi

    2012-01-01

    Sake yeast cells have defective entry into the quiescent state, allowing them to sustain high fermentation rates. To reveal the underlying mechanism, we investigated the PAS kinase Rim15p, which orchestrates initiation of the quiescence program in Saccharomyces cerevisiae. We found that Rim15p is truncated at the carboxyl terminus in modern sake yeast strains as a result of a frameshift mutation. Introduction of this mutation or deletion of the full-length RIM15 gene in a laboratory strain led to a defective stress response, decreased synthesis of the storage carbohydrates trehalose and glycogen, and impaired G1 arrest, which together closely resemble the characteristic phenotypes of sake yeast. Notably, expression of a functional RIM15 gene in a modern sake strain suppressed all of these phenotypes, demonstrating that dysfunction of Rim15p prevents sake yeast cells from entering quiescence. Moreover, loss of Rim15p or its downstream targets Igo1p and Igo2p remarkably improved the fermentation rate in a laboratory strain. This finding verified that Rim15p-mediated entry into quiescence plays pivotal roles in the inhibition of ethanol fermentation. Taken together, our results suggest that the loss-of-function mutation in the RIM15 gene may be the key genetic determinant of the increased ethanol production rates in modern sake yeast strains. PMID:22447585

  7. Fruit Exocarp Phenols in Relation to Quiescence and Development of Monilinia fructicola Infections in Prunus spp.: A Role for Cellular Redox?

    PubMed

    Lee, Miin-Huey; Bostock, Richard M

    2007-03-01

    ABSTRACT Monilinia fructicola causes brown rot of Prunus species and usually remains quiescent on immature fruit but reactivates when fruit are mature. The dihydroxycinnamates caffeic acid and its quinate ester, chlorogenic acid, abundant in the exocarp of peach fruit, had no effect on fungal growth but markedly inhibited the production of the cell wall degrading enzymes polygalacturonase and cutinase in M. fructicola cultures. This inhibition was related to changes in the electrochemical redox potentials of the cultures, as measured with a redox electrode. Fungal culture filtrates had lower electrochemical redox potentials when the growth medium contained caffeic acid than in caffeic acid-free medium. Levels of total intracellular glutathione, the reduced form of which serves as a major cellular antioxidant, increased significantly in M. fructicola cells in response to external caffeic acid. The presence of caffeic acid, chlorogenic acid, or reduced glutathione in conidial suspensions of M. fructicola did not inhibit germination on flower petals and fruit, but inhibited appressorium formation from germinated conidia and subsequent brown rot lesion development. These results suggest that intracellular antioxidant levels in the pathogen can be influenced by phenols present in host tissue and that changes in the redox environment may influence gene expression and differentiation of structures associated with infection by the pathogen. The possible relationship of host phenols to quiescence and subsequent development of M. fructicola infections is discussed.

  8. Molecular analysis of the early interaction between the grapevine flower and Botrytis cinerea reveals that prompt activation of specific host pathways leads to fungus quiescence.

    PubMed

    Mehari, Zeraye H; Pilati, Stefania; Sonego, Paolo; Malacarne, Giulia; Vrhovsek, Urska; Engelen, Kristof; Tudzynski, Paul; Zottini, Michela; Baraldi, Elena; Moser, Claudio

    2017-02-27

    Grapes quality and yield can be impaired by bunch rot, caused by the necrotrophic fungus Botrytis cinerea. Infection often occurs at flowering and the pathogen stays quiescent until fruit maturity. Here, we report a molecular analysis of the early interaction between B. cinerea and Vitis vinifera flowers, using a controlled infection system, confocal microscopy and integrated transcriptomic and metabolic analysis of the host and the pathogen. Flowers from fruiting cuttings of the cv. Pinot Noir were infected with GFP-labeled B. cinerea and studied at 24 and 96 hours post inoculation (hpi). We observed that penetration of the epidermis by B. cinerea coincided with increased expression of genes encoding cell wall-degrading enzymes, phytotoxins, and proteases. Grapevine responded with a rapid defense reaction involving 1193 genes associated with the accumulation of antimicrobial proteins, polyphenols, reactive oxygen species and cell wall reinforcement. At 96 hpi the reaction appears largely diminished both in the host and in the pathogen. Our data indicate that the defense responses of the grapevine flower collectively are able to restrict invasive fungal growth into the underlying tissues, thereby forcing the fungus to enter quiescence until the conditions become more favorable to resume pathogenic development.

  9. An Effector Phenotype of CD8+ T Cells at the Junction Epithelium during Clinical Quiescence of Herpes Simplex Virus 2 Infection

    PubMed Central

    Peng, Tao; Zhu, Jia; Phasouk, Khamsone; Koelle, David M.; Wald, Anna

    2012-01-01

    Herpes simplex virus 2 infection is characterized by cycles of viral quiescence and reactivation. CD8+ T cells persist at the site of viral reactivation, at the genital dermal-epidermal junction contiguous to neuronal endings of sensory neurons, for several months after herpes lesion resolution. To evaluate whether these resident CD8+ T cells frequently encounter HSV antigen even during times of asymptomatic viral infection, we analyzed the transcriptional output of CD8+ T cells captured by laser microdissection from human genital skin biopsy specimens during the clinically quiescent period of 8 weeks after lesion resolution. These CD8+ T cells expressed a characteristic set of genes distinct from those of three separate control cell populations, and network and pathway analyses revealed that these T cells significantly upregulated antiviral genes such as GZMB, PRF1, INFG, IL-32, and LTA, carbohydrate and lipid metabolism-related genes such as GLUT-1, and chemotaxis and recruitment genes such as CCL5 and CCR1, suggesting a possible feedback mechanism for the recruitment of CD8+ T cells to the site of infection. Many of these transcripts are known to have half-lives of <48 h, suggesting that cognate antigen is released frequently into the mucosa and that resident CD8+ T cells act as functional effectors in controlling viral spread. PMID:22811543

  10. DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

    PubMed Central

    Barr, Alexis R.; Cooper, Samuel; Heldt, Frank S.; Butera, Francesca; Stoy, Henriette; Mansfeld, Jörg; Novák, Béla; Bakal, Chris

    2017-01-01

    Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic stability in the absence of exogenous DNA-damaging agents is unclear. Here, using live single-cell measurements of p21 protein in proliferating cultures, we show that naturally occurring DNA damage incurred over S-phase causes p53-dependent accumulation of p21 during mother G2- and daughter G1-phases. High p21 levels mediate G1 arrest via CDK inhibition, yet lower levels have no impact on G1 progression, and the ubiquitin ligases CRL4Cdt2 and SCFSkp2 couple to degrade p21 prior to the G1/S transition. Mathematical modelling reveals that a bistable switch, created by CRL4Cdt2, promotes irreversible S-phase entry by keeping p21 levels low, preventing premature S-phase exit upon DNA damage. Thus, we characterize how p21 regulates the proliferation-quiescence decision to maintain genomic stability. PMID:28317845

  11. A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling.

    PubMed

    Lorz, Corina; García-Escudero, Ramón; Segrelles, Carmen; Garín, Marina I; Ariza, José M; Santos, Mirentxu; Ruiz, Sergio; Lara, María F; Martínez-Cruz, Ana B; Costa, Clotilde; Buitrago-Pérez, Agueda; Saiz-Ladera, Cristina; Dueñas, Marta; Paramio, Jesús M

    2010-06-01

    Continuous cell renewal in mouse epidermis is at the expense of a pool of pluripotent cells that lie in a well defined niche in the hair follicle known as the bulge. To identify mechanisms controlling hair follicle stem cell homeostasis, we developed a strategy to isolate adult bulge stem cells in mice and to define their transcriptional profile. We observed that a large number of transcripts are underexpressed in hair follicle stem cells when compared to non-stem cells. Importantly, the majority of these downregulated genes are involved in cell cycle. Using bioinformatics tools, we identified the E2F transcription factor family as a potential element involved in the regulation of these transcripts. To determine their functional role, we used engineered mice lacking Rb gene in epidermis, which showed increased expression of most E2F family members and increased E2F transcriptional activity. Experiments designed to analyze epidermal stem cell functionality (i.e.: hair regrowth and wound healing) imply a role of the Rb-E2F axis in the control of stem cell quiescence in epidermis.

  12. A Functional Role of RB-Dependent Pathway in the Control of Quiescence in Adult Epidermal Stem Cells Revealed by Genomic Profiling

    PubMed Central

    Lorz, Corina; García-Escudero, Ramón; Segrelles, Carmen; Garín, Marina I.; Ariza, José M.; Santos, Mirentxu; Ruiz, Sergio; Lara, María F.; Martínez-Cruz, Ana B.; Costa, Clotilde; Buitrago-Pérez, Águeda; Saiz-Ladera, Cristina; Dueñas, Marta

    2010-01-01

    Continuous cell renewal in mouse epidermis is at the expense of a pool of pluripotent cells that lie in a well defined niche in the hair follicle known as the bulge. To identify mechanisms controlling hair follicle stem cell homeostasis, we developed a strategy to isolate adult bulge stem cells in mice and to define their transcriptional profile. We observed that a large number of transcripts are underexpressed in hair follicle stem cells when compared to non-stem cells. Importantly, the majority of these downregulated genes are involved in cell cycle. Using bioinformatics tools, we identified the E2F transcription factor family as a potential element involved in the regulation of these transcripts. To determine their functional role, we used engineered mice lacking Rb gene in epidermis, which showed increased expression of most E2F family members and increased E2F transcriptional activity. Experiments designed to analyze epidermal stem cell functionality (i.e.: hair regrowth and wound healing) imply a role of the Rb-E2F axis in the control of stem cell quiescence in epidermis. Electronic supplementary material The online version of this article (doi:10.1007/s12015-010-9139-0) contains supplementary material, which is available to authorized users. PMID:20376578

  13. DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.

    PubMed

    Barr, Alexis R; Cooper, Samuel; Heldt, Frank S; Butera, Francesca; Stoy, Henriette; Mansfeld, Jörg; Novák, Béla; Bakal, Chris

    2017-03-20

    Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic stability in the absence of exogenous DNA-damaging agents is unclear. Here, using live single-cell measurements of p21 protein in proliferating cultures, we show that naturally occurring DNA damage incurred over S-phase causes p53-dependent accumulation of p21 during mother G2- and daughter G1-phases. High p21 levels mediate G1 arrest via CDK inhibition, yet lower levels have no impact on G1 progression, and the ubiquitin ligases CRL4(Cdt2) and SCF(Skp2) couple to degrade p21 prior to the G1/S transition. Mathematical modelling reveals that a bistable switch, created by CRL4(Cdt2), promotes irreversible S-phase entry by keeping p21 levels low, preventing premature S-phase exit upon DNA damage. Thus, we characterize how p21 regulates the proliferation-quiescence decision to maintain genomic stability.

  14. Melanoma dormancy in a mouse model is linked to GILZ/FOXO3A-dependent quiescence of disseminated stem-like cells

    PubMed Central

    Touil, Yasmine; Segard, Pascaline; Ostyn, Pauline; Begard, Severine; Aspord, Caroline; El Machhour, Raja; Masselot, Bernadette; Vandomme, Jerome; Flamenco, Pilar; Idziorek, Thierry; Figeac, Martin; Formstecher, Pierre; Quesnel, Bruno; Polakowska, Renata

    2016-01-01

    Metastatic cancer relapses following the reactivation of dormant, disseminated tumour cells; however, the cells and factors involved in this reactivation are just beginning to be identified. Using an immunotherapy-based syngeneic model of melanoma dormancy and GFP-labelled dormant cell-derived cell lines, we determined that vaccination against melanoma prevented tumour growth but did not prevent tumour cell dissemination or eliminate all tumour cells. The persistent disseminated melanoma tumour cells were quiescent and asymptomatic for one year. The quiescence/activation of these cells in vitro and the dormancy of melanoma in vivo appeared to be regulated by glucocorticoid-induced leucine zipper (GILZ)-mediated immunosuppression. GILZ expression was low in dormant cell-derived cultures, and re-expression of GILZ inactivated FOXO3A and its downstream target, p21CIP1. The ability of dormancy-competent cells to re-enter the cell cycle increased after a second round of cellular dormancy in vivo in association with shortened tumour dormancy period and faster and more aggressive melanoma relapse. Our data indicate that future cancer treatments should be adjusted according to the stage of disease progression. PMID:27465291

  15. Resistance to dehydration between bouts of blood feeding in the bed bug, Cimex lectularius, is enhanced by water conservation, aggregation, and quiescence.

    PubMed

    Benoit, Joshua B; Del Grosso, Nicholas A; Yoder, Jay A; Denlinger, David L

    2007-05-01

    To determine how the bed bug, Cimex lectularius, survives in a dry environment for many months without feeding, water-balance characteristics were compared for all stages from first-instar nymphs to adults. This species is characterized by a low net transpiration rate averaging < 0.2%/h, high tolerance for dehydration (30-40% loss in body water), and an impermeable cuticle as indicated by a high critical transition temperature (CTT) in the 35-40 degrees C range, implying that this insect is adapted for desiccation-hardiness. The capacity of adults to survive for 2 weeks at 0.00a(v) (a(v) = % RH/100) with no access to food or water exemplifies this trait. In contrast to more mature stages, first-instar nymphs contain more water, lose water at a faster rate, experience abrupt water loss at a lower temperature, and survive less time in dry air, suggesting that this stage is the most sensitive to water stress. This insect relies on blood to replenish water stores; none of the stages examined have the capacity to absorb water vapor (critical equilibrium activity, CEA > or = 0.99a(v)), and they drank only sparingly when offered free water. As the bed bugs progress through their development, they gradually reduce their water requirements while increasing their desiccation resistance. Surviving water stress is considerably enhanced behaviorally by quiescence, characterized by prolonged periods of inactivity, and by the formation of clusters that generate a water-conserving group effect.

  16. Comparison of the Recently proposed Super Marx Generator Approach to Thermonuclear Ignition with the DT Laser Fusion-Fission Hybrid Concept (LIFE) by the Lawrence Livermore National Laboratory.

    NASA Astrophysics Data System (ADS)

    Winterberg, Friedwardt

    2009-05-01

    The recently proposed Super Marx pure deuterium micro-detonation ignition concept [1] is compared to the Lawrence Livermore National Ignition Facility (NIF) laser DT fusion-fission hybrid concept (LIFE) [2]. A typical example of the LIFE concept is a fusion gain 30, and a fission gain of 10, making up for a total gain of 300, with about 10 times more energy released into fission as compared to fusion. This means a substantial release of fission products, as in fusion-less pure fission reactors. In the Super Marx approach for the ignition of a pure deuterium micro-detonation gains of the same magnitude can in theory be reached. If the theoretical prediction can be supported by more elaborate calculations, the Super Marx approach is likely to make lasers obsolete as a means for the ignition of thermonuclear micro-explosions. [1] ``Ignition of a Deuterium Micro-Detonation with a Gigavolt Super Marx Generator,'' Winterberg, F., Journal of Fusion Energy, Springer, 2008. http://www.springerlink.com/content/r2j046177j331241/fulltext.pdf. [2] ``LIFE: Clean Energy from Nuclear Waste,'' https://lasers.llnl.gov/missions/energy&_slash;for&_slash;the&_slash;future/life/

  17. Effect of particle pinch on the fusion performance and profile features of an international thermonuclear experimental reactor-like fusion reactor

    SciTech Connect

    Wang, Shijia Wang, Shaojie

    2015-04-15

    The evolution of the plasma temperature and density in an international thermonuclear experimental reactor (ITER)-like fusion device has been studied by numerically solving the energy transport equation coupled with the particle transport equation. The effect of particle pinch, which depends on the magnetic curvature and the safety factor, has been taken into account. The plasma is primarily heated by the alpha particles which are produced by the deuterium-tritium fusion reactions. A semi-empirical method, which adopts the ITERH-98P(y,2) scaling law, has been used to evaluate the transport coefficients. The fusion performances (the fusion energy gain factor, Q) similar to the ITER inductive scenario and non-inductive scenario (with reversed magnetic shear) are obtained. It is shown that the particle pinch has significant effects on the fusion performance and profiles of a fusion reactor. When the volume-averaged density is fixed, particle pinch can lower the pedestal density by ∼30%, with the Q value and the central pressure almost unchanged. When the particle source or the pedestal density is fixed, the particle pinch can significantly enhance the Q value by  60%, with the central pressure also significantly raised.

  18. EX Lupi from Quiescence to Outburst: Exploring the LTE Approach in Modeling Blended H2O and OH Mid-infrared Emission

    NASA Astrophysics Data System (ADS)

    Banzatti, A.; Meyer, M. R.; Bruderer, S.; Geers, V.; Pascucci, I.; Lahuis, F.; Juhász, A.; Henning, T.; Ábrahám, P.

    2012-01-01

    We present a comparison of archival Spitzer spectra of the strongly variable T Tauri EX Lupi, observed before and during its 2008 outburst. We analyze the mid-infrared emission from gas-phase molecules thought to originate in a circumstellar disk. In quiescence the emission shows a forest of H2O lines, highly excited OH lines, and the Q branches of the organics C2H2, HCN, and CO2, similar to the emission observed toward several T Tauri systems. The outburst emission shows instead remarkable changes: H2O and OH line fluxes increase, new OH, H2, and H I transitions are detected, and organics are no longer seen. We adopt a simple model of a single-temperature slab of gas in local thermal equilibrium, a common approach for molecular analyses of Spitzer spectra, and derive the excitation temperature, column density, and emitting area of H2O and OH. We show how model results strongly depend on the selection of emission lines fitted and how this is likely to be attributed to a combination of non-thermal excitation and multiple emission components. Using H2O lines that can be approximated as thermalized to a single temperature, our results are consistent with a column density decrease in outburst while the emitting area of warm gas increases. A rotation diagram analysis suggests that the OH emission can be explained with two temperature components, which remarkably increase in column density in outburst. The relative change of H2O and OH emission suggests a key role for UV radiation in the disk surface chemistry.

  19. EX Lupi FROM QUIESCENCE TO OUTBURST: EXPLORING THE LTE APPROACH IN MODELING BLENDED H{sub 2}O AND OH MID-INFRARED EMISSION

    SciTech Connect

    Banzatti, A.; Meyer, M. R.; Bruderer, S.; Geers, V.; Pascucci, I.; Lahuis, F.; Juhasz, A.; Henning, T.; Abraham, P.

    2012-01-20

    We present a comparison of archival Spitzer spectra of the strongly variable T Tauri EX Lupi, observed before and during its 2008 outburst. We analyze the mid-infrared emission from gas-phase molecules thought to originate in a circumstellar disk. In quiescence the emission shows a forest of H{sub 2}O lines, highly excited OH lines, and the Q branches of the organics C{sub 2}H{sub 2}, HCN, and CO{sub 2}, similar to the emission observed toward several T Tauri systems. The outburst emission shows instead remarkable changes: H{sub 2}O and OH line fluxes increase, new OH, H{sub 2}, and H I transitions are detected, and organics are no longer seen. We adopt a simple model of a single-temperature slab of gas in local thermal equilibrium, a common approach for molecular analyses of Spitzer spectra, and derive the excitation temperature, column density, and emitting area of H{sub 2}O and OH. We show how model results strongly depend on the selection of emission lines fitted and how this is likely to be attributed to a combination of non-thermal excitation and multiple emission components. Using H{sub 2}O lines that can be approximated as thermalized to a single temperature, our results are consistent with a column density decrease in outburst while the emitting area of warm gas increases. A rotation diagram analysis suggests that the OH emission can be explained with two temperature components, which remarkably increase in column density in outburst. The relative change of H{sub 2}O and OH emission suggests a key role for UV radiation in the disk surface chemistry.

  20. XMM-Newton and INTEGRAL study of the SFXT IGR J18483-0311 in quiescence: hint of a cyclotron emission feature?

    NASA Astrophysics Data System (ADS)

    Sguera, V.; Ducci, L.; Sidoli, L.; Bazzano, A.; Bassani, L.

    2010-02-01

    We report the results from archival XMM-Newton and INTEGRAL observations of the Supergiant Fast X-ray Transient (SFXT) IGR J18483-0311 in quiescence. The 18-60 keV hard X-ray behaviour of the source is presented here for the first time; it is characterized by a spectral shape (Γ ~ 2.5) similar to that during outburst activity, and the lowest measured luminosity level is ~1034 erg s-1. The 0.5-10 keV luminosity state, measured by XMM-Newton during the apastron passage, is about one order of magnitude lower and it is reasonably fitted by an absorbed blackbody model yielding parameters consistent with previous measurements. In addition, we find evidence (~3.5σ significance) of an emission-like feature at ~3.3 keV in the quiescent 0.5-10 keV source spectrum. The absence of any known or found systematic effects, which could artificially introduce the observed feature, gives us confidence about its non-instrumental nature. We show that its physical explanation in terms of atomic emission line appears unlikely, and conversely we attempt to ascribe it to an electron cyclotron emission line which would imply a neutron star magnetic field of the order of ~3 × 1011 G. Importantly, such direct estimation is in very good agreement with that independently inferred by us in the framework of accretion from a spherically symmetric stellar wind. If firmly confirmed by future longer X-ray observations, this would be the first detection ever of a cyclotron feature in the X-ray spectrum of an SFXT, with important implications on theoretical models.

  1. OPTICAL THERMONUCLEAR TRANSIENTS FROM TIDAL COMPRESSION OF WHITE DWARFS AS TRACERS OF THE LOW END OF THE MASSIVE BLACK HOLE MASS FUNCTION

    SciTech Connect

    MacLeod, Morgan; Ramirez-Ruiz, Enrico; Guillochon, James; Kasen, Daniel; Rosswog, Stephan

    2016-03-01

    In this paper, we model the observable signatures of tidal disruptions of white dwarf (WD) stars using massive black holes (MBHs) of moderate mass, ≈10{sup 3}–10{sup 5} M{sub ⊙}. When the WD passes deep enough within the MBH’s tidal field, these signatures include thermonuclear transients from burning during maximum compression. We combine a hydrodynamic simulation that includes nuclear burning of the disruption of a 0.6 M{sub ⊙} C/O WD with a Monte Carlo radiative transfer calculation to synthesize the properties of a representative transient. The transient’s emission emerges in the optical, with light curves and spectra reminiscent of Type I supernovae. The properties are strongly viewing angle dependent, and key spectral signatures are ≈10,000 km s{sup −1} doppler shifts, due to the orbital motion of the unbound ejecta. Disruptions of He WDs likely produce large quantities of intermediate-mass elements, offering a possible production mechanism for Ca-rich transients. Accompanying multi-wavelength transients are fueled by accretion and arise from the nascent accretion disk and relativistic jet. If MBHs of moderate mass exist with number densities similar to those of supermassive BHs, both high-energy wide-field monitors and upcoming optical surveys should detect tens to hundreds of WD tidal disruptions per year. The current best strategy for their detection may therefore be deep optical follow-up of high-energy transients of unusually long duration. The detection rate or the nondetection of these transients by current and upcoming surveys can thus be used to place meaningful constraints on the extrapolation of the MBH mass function to moderate masses.

  2. Optical Thermonuclear Transients from Tidal Compression of White Dwarfs as Tracers of the Low End of the Massive Black Hole Mass Function

    NASA Astrophysics Data System (ADS)

    MacLeod, Morgan; Guillochon, James; Ramirez-Ruiz, Enrico; Kasen, Daniel; Rosswog, Stephan

    2016-03-01

    In this paper, we model the observable signatures of tidal disruptions of white dwarf (WD) stars using massive black holes (MBHs) of moderate mass, ≈103-105 M⊙. When the WD passes deep enough within the MBH’s tidal field, these signatures include thermonuclear transients from burning during maximum compression. We combine a hydrodynamic simulation that includes nuclear burning of the disruption of a 0.6 M⊙ C/O WD with a Monte Carlo radiative transfer calculation to synthesize the properties of a representative transient. The transient’s emission emerges in the optical, with light curves and spectra reminiscent of Type I supernovae. The properties are strongly viewing angle dependent, and key spectral signatures are ≈10,000 km s-1 doppler shifts, due to the orbital motion of the unbound ejecta. Disruptions of He WDs likely produce large quantities of intermediate-mass elements, offering a possible production mechanism for Ca-rich transients. Accompanying multi-wavelength transients are fueled by accretion and arise from the nascent accretion disk and relativistic jet. If MBHs of moderate mass exist with number densities similar to those of supermassive BHs, both high-energy wide-field monitors and upcoming optical surveys should detect tens to hundreds of WD tidal disruptions per year. The current best strategy for their detection may therefore be deep optical follow-up of high-energy transients of unusually long duration. The detection rate or the nondetection of these transients by current and upcoming surveys can thus be used to place meaningful constraints on the extrapolation of the MBH mass function to moderate masses.

  3. Investigation of the thermonuclear 18Ne(α,p)21Na reaction rate via resonant elastic scattering of 21Na + p

    NASA Astrophysics Data System (ADS)

    Zhang, L. Y.; He, J. J.; Parikh, A.; Xu, S. W.; Yamaguchi, H.; Kahl, D.; Kubono, S.; Mohr, P.; Hu, J.; Ma, P.; Chen, S. Z.; Wakabayashi, Y.; Wang, H. W.; Tian, W. D.; Chen, R. F.; Guo, B.; Hashimoto, T.; Togano, Y.; Hayakawa, S.; Teranishi, T.; Iwasa, N.; Yamada, T.; Komatsubara, T.; Zhang, Y. H.; Zhou, X. H.

    2014-01-01

    The 18Ne(α,p)21Na reaction is thought to be one of the key breakout reactions from the hot CNO cycles to the rp process in type I x-ray bursts. In this work, the resonant properties of the compound nucleus 22Mg have been investigated by measuring the resonant elastic scattering of 21Na + p. An 89-MeV 21Na radioactive beam delivered from the CNS Radioactive Ion Beam Separator bombarded an 8.8 mg/cm2 thick polyethylene (CH2)n target. The 21Na beam intensity was about 2×105 pps, with a purity of about 70% on target. The recoiled protons were measured at the center-of-mass scattering angles of θc.m.≈175.2∘, 152.2∘, and 150.5∘ by three sets of ΔE-E telescopes, respectively. The excitation function was obtained with the thick-target method over energies Ex(22Mg)=5.5-9.2 MeV. In total, 23 states above the proton-threshold in 22Mg were observed, and their resonant parameters were determined via an R-matrix analysis of the excitation functions. We have made several new Jπ assignments and confirmed some tentative assignments made in previous work. The thermonuclear 18Ne(α,p)21Na rate has been recalculated based on our recommended spin-parity assignments. The astrophysical impact of our new rate has been investigated through one-zone postprocessing x-ray burst calculations. We find that the 18Ne(α,p)21Na rate significantly affects the peak nuclear energy generation rate, reaction fluxes, and onset temperature of this breakout reaction in these astrophysical phenomena.

  4. Development of a Jones vector based model for the measurement of a plasma current in a thermonuclear fusion reactor with a POTDR setup

    NASA Astrophysics Data System (ADS)

    Aerssens, M.; Gusarov, A.; Moreau, P.; Malard, P.; Massaut, V.; Mégret, P.; Wuilpart, M.

    2012-04-01

    Fibre optical current sensor (FOCS) is a promising alternative to inductive sensors for the measurement of the plasma current in future thermonuclear fusion reactors. Standard FOCS relies on the measurement of the state of polarisation (SOP) of light at the output of an optical bre surrounding a current. Because of the Faraday eect, magnetic eld induced by electrical current rotates the SOP of light travelling into the bre. According to the Ampere's theorem this rotation is proportional to the surrounded current. In future tokamaks like ITER and DEMO, the plasma current will be suciently high to generate a rotation of the SOP higher than 2 radians. These conditions may lead to uncertainties on the determination of the plasma current if no post processing is performed. In this paper we propose a solution with a Polarisation Optical Time Domain Re ectometer (POTDR) setup allowing both unambiguous plasma current measurement and also local magnetic eld measurements. This measurement is based on the assessment of the SOP rotation of the Rayleigh backscattered POTDR signal. Thanks to the presence of an input polarizer, SOP variations are converted into power uctuations that contain information about the distribution of the magnetic eld and therefore about the plasma current. Using the Jones formalism we have developed a model accounting for the modication of the SOP of light travelling into the optical bre and the evolution of the POTDR signal. In parallel experimental PODTR measurements have been performed on the Tore Supra tokamak situated at CEA Cadarache in France. A comparison between the models and the experimental results conrms the capability of the system to measure the plasma current and the local magnetic eld even if further data post processing are still required.

  5. A randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome.

    PubMed

    Grote, Ludger; Leissner, Lena; Hedner, Jan; Ulfberg, Jan

    2009-07-30

    Iron deficiency may exacerbate symptoms in the Restless Legs Syndrome (RLS). We investigated the effect of intravenous iron sucrose or placebo on symptoms in patients with RLS and mild to moderate iron deficit. Sixty patients with primary RLS (seven males, age 46 (9) years, S-ferritin < or =45 microg/L) recruited from a cohort of 231 patients were randomly assigned in a 12-months double-blind, multi-centre study of iron sucrose 1000 mg (n = 29) or saline (n = 31). The primary efficacy variable was the RLS severity scale (IRLS) score at week 11. Median IRLS score decreased from 24 to 7 (week 11) after iron sucrose and from 26 to 17 after placebo (P = 0.123, N.S. for between treatment comparison). The corresponding scores at week 7 were 12 and 20 in the two groups (P = 0.017). Drop out rate because of lack of efficacy at 12 months was 19/31 after placebo and 5/29 patients after iron sucrose (Kaplan-Meier estimate, log rank test P = 0.0006) suggesting an iron induced superior long term RLS symptom control. Iron sucrose was well tolerated. This study showed a lack of superiority of iron sucrose at 11 weeks but found evidence that iron sucrose reduced RLS symptoms both in the acute phase (7 weeks) and during long-term follow up in patients with variable degree of iron deficiency. Further studies on target patient groups, dosing and dosing intervals are warranted before iron sucrose could be considered for treatment of iron deficient patients with RLS.

  6. A Comparative Randomized Controlled Clinical Trial on the Effectiveness, Safety, and Tolerability of a Homeopathic Medicinal Product in Children with Sleep Disorders and Restlessness

    PubMed Central

    Jong, Miek C.; Ilyenko, Lydia; Kholodova, Irina; Verwer, Cynthia; Burkart, Julia; Weber, Stephan; Keller, Thomas; Klement, Petra

    2016-01-01

    A prospective, multicenter, randomized, open-label, controlled clinical trial was performed to evaluate the effectiveness and safety of the homeopathic product ZinCyp-3-02 in children with sleep disorders for ≥ one month compared to glycine. Children ≤ six years old received either ZinCyp-3-02 (N = 89) or comparator glycine (N = 90). After treatment for 28 days, total sleep-disorder-associated complaints severity scores decreased in both groups from median 7.0 (out of maximum 11.0) points to 2.0 (ZinCyp-3-02) and 4.0 (glycine) points, respectively, with overall higher odds of showing improvement for ZinCyp-3-02 (odds ratio: 4.45 (95% CI: 2.77–7.14), p < 0.0001, POM overall treatment related effect). Absence of individual complaints (time to sleep onset, difficulties maintaining sleep, sleep duration, troubled sleep (somniloquism), physical inactivity after awakening, restlessness for unknown reason, and sleep disorders frequency) at study end were significantly higher with ZinCyp-3-02 (all p values < 0.05). More children with ZinCyp-3-02 were totally free of complaints (p = 0.0258). Treatment effectiveness (p < 0.0001) and satisfaction assessments (p < 0.0001) were more favorable for ZinCyp-3-02. Few nonserious adverse drug reactions were reported (ZinCyp-3-02: N = 2, glycine: N = 1) and both treatments were well tolerated. Treatment with the homeopathic product ZinCyp-3-02 was found to be safe and superior to the comparator glycine in the treatment of sleep disorders in children. PMID:27242915

  7. Targeted Resequencing and Systematic In Vivo Functional Testing Identifies Rare Variants in MEIS1 as Significant Contributors to Restless Legs Syndrome

    PubMed Central

    Schulte, Eva C.; Kousi, Maria; Tan, Perciliz L.; Tilch, Erik; Knauf, Franziska; Lichtner, Peter; Trenkwalder, Claudia; Högl, Birgit; Frauscher, Birgit; Berger, Klaus; Fietze, Ingo; Hornyak, Magdolna; Oertel, Wolfgang H.; Bachmann, Cornelius G.; Zimprich, Alexander; Peters, Annette; Gieger, Christian; Meitinger, Thomas; Müller-Myhsok, Bertram; Katsanis, Nicholas; Winkelmann, Juliane

    2014-01-01

    Restless legs syndrome (RLS) is a common neurologic condition characterized by nocturnal dysesthesias and an urge to move, affecting the legs. RLS is a complex trait, for which genome-wide association studies (GWASs) have identified common susceptibility alleles of modest (OR 1.2–1.7) risk at six genomic loci. Among these, variants in MEIS1 have emerged as the largest risk factors for RLS, suggesting that perturbations in this transcription factor might be causally related to RLS susceptibility. To establish this causality, direction of effect, and total genetic burden of MEIS1, we interrogated 188 case subjects and 182 control subjects for rare alleles not captured by previous GWASs, followed by genotyping of ∼3,000 case subjects and 3,000 control subjects, and concluded with systematic functionalization of all discovered variants using a previously established in vivo model of neurogenesis. We observed a significant excess of rare MEIS1 variants in individuals with RLS. Subsequent assessment of all nonsynonymous variants by in vivo complementation revealed an excess of loss-of-function alleles in individuals with RLS. Strikingly, these alleles compromised the function of the canonical MEIS1 splice isoform but were irrelevant to an isoform known to utilize an alternative 3′ sequence. Our data link MEIS1 loss of function to the etiopathology of RLS, highlight how combined sequencing and systematic functional annotation of rare variation at GWAS loci can detect risk burden, and offer a plausible explanation for the specificity of phenotypic expressivity of loss-of-function alleles at a locus broadly necessary for neurogenesis and neurodevelopment. PMID:24995868

  8. In vivo mesolimbic D2/3 receptor binding predicts posttherapeutic clinical responses in restless legs syndrome: a positron emission tomography study.

    PubMed

    Oboshi, Yumi; Ouchi, Yasuomi; Yagi, Shunsuke; Kono, Satoshi; Nakai, Noriyoshi; Yoshikawa, Etsuji; Futatsubashi, Masami; Terada, Tatsuhiro; Kim, Kang; Harada, Kiyoshi

    2012-04-01

    Although D2/3 agonists have been used as a first-line medication for idiopathic restless legs syndrome (iRLS), findings on D2/3 receptors have been inconsistent. Here, we aimed to clarify the contribution of D2/3 receptor function to the clinical symptoms of iRLS by comparing the binding potential (BP(ND)) of [(11)C]raclopride with clinical improvements after D2/3 stimulation by pramipexole. Eight drug-naïve, iRLS patients and eight age-matched healthy subjects were scanned with positron emission tomography (PET). After PET scans, all patients received pramipexole (0.125 mg) orally for 2 weeks. Patients were evaluated every day with several standardized clinical tests. The BP(ND) values were compared using regions of interest and voxel-based methods. Results showed that the mean magnitude of [(11)C]raclopride BP(ND) in the mesolimbic dopamine region (nucleus accumbens (NA) and caudate) was significantly lower in the iRLS group. No significant differences between groups were observed in the putamen. The NA [(11)C]raclopride BP(ND) levels correlated negatively with clinical severity scores and positively with the degree of posttreatment improvement in iRLS. The present results suggest that alterations in mesolimbic D2/3 receptor function reflect the pathophysiology of iRLS, and the baseline availability of D2/3 receptors may predict the clinical outcome after D2/3 agonist treatment.

  9. Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole. 1. Findings on objective and subjective sleep and awakening quality.

    PubMed

    Saletu, B; Gruber, G; Saletu, M; Brandstätter, N; Hauer, C; Prause, W; Ritter, K; Saletu-Zyhlarz, G

    2000-01-01

    Although the restless legs syndrome (RLS) is a disorder with a relatively high prevalence rate (8% in Austria) and leads to insomnia and excessive daytime tiredness, there is a paucity of sleep laboratory data concerning objective and subjective sleep and awakening quality. Thus, the aim of this study was to investigate 12 untreated RLS patients as compared with 12 normal controls and subsequently measure the acute effects of 0.5 mg ropinirole (Requip((R))) - a nonergoline dopamine agonist - as compared with placebo. In 3 nights (adaptation, placebo, ropinirole night) sleep induction, maintenance and architecture were measured objectively by polysomnography, subjective sleep and awakening quality were assessed by self-rating scales and visual-analog scales, and objective awakening quality was evaluated by a psychometric test battery. In polysomnography, RLS patients demonstrated, as compared with normal controls, a decreased total sleep time (TST) and sleep efficacy, increased wakefulness during the total sleep period and frequency of nocturnal awakenings, increased sleep stage S1, decreased S2 and increased stage shifts. Subjective sleep quality tended to decrease, and morning well-being, mood, affectivity and wakefulness were deteriorated. In the noopsyche, fine motor activity and reaction time performance were deteriorated. Ropinirole 0.5 mg induced, as compared with placebo, an increase in TST, sleep efficacy, S2 sleep and stage shifts. In the morning, somatic complaints increased slightly, while fine motor activity and reaction time performance improved. Our findings suggest a key-lock principle in the diagnosis/treatment of RLS and a dopaminergic mechanism in its pathogenesis, which is supported by the data on periodic leg movements during sleep and arousals of the subsequent paper.

  10. Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trial.

    PubMed

    Trenkwalder, Claudia; Benes, Heike; Grote, Ludger; Happe, Svenja; Högl, Birgit; Mathis, Johannes; Saletu-Zyhlarz, Gerda M; Kohnen, Ralf

    2007-04-15

    We report the first large-scale double-blind, randomly assigned study to compare two active dopaminergic therapies for Restless Legs Syndrome (RLS), the dopamine agonist cabergoline (CAB) and levodopa/benserazide (levodopa). Patients with idiopathic RLS were treated with fixed daily doses of 2 or 3 mg CAB or 200 or 300 mg levodopa for 30 weeks. Efficacy was assessed by changes in the IRLS (International RLS Severity Scale) and by time to discontinuation of treatment due to loss of efficacy or augmentation. 361 of 418 screened patients (age 58 +/- 12 years, 71% females) were randomly assigned and treated (CAB: n = 178; levodopa: n = 183) in 51 centers of four European countries. Baseline IRLS total score was 25.7 +/- 6.8. The baseline-adjusted mean change from baseline to week 6 in IRLS sum score was d = -16.1 in the CAB group and d = -9.5 in the levodopa group (d = -6.6, P < 0.0001). More patients in the levodopa group (24.0%) than in the CAB group (11.9%, P = 0.0029, log-rank test) discontinued because of loss of efficacy (14.2% vs. 7.9%, P = 0.0290) or augmentation (9.8% vs. 4.0%, P = 0.0412). Adverse events (AEs) occurred in 83.1% of the CAB group and in 77.6% of the levodopa group. In both groups, most frequent AEs were gastrointestinal symptoms (CAB: 55.6%, levodopa: 30.6%, P < 0.0001). This first large-scale active controlled study in RLS showed superior efficacy of cabergoline versus levodopa after a 30-week long-term therapy. Tolerability was found more favorable with levodopa than with cabergoline.

  11. A double-blind, randomized, controlled trial to compare the efficacy and tolerability of fixed doses of ropinirole, bupropion, and iron in treatment of restless legs syndrome (Willis–Ekbom disease)

    PubMed Central

    Vishwakarma, Kirti; Kalra, Juhi; Gupta, Ravi; Sharma, Mukesh; Sharma, Taruna

    2016-01-01

    Background: We aimed to compare the efficacy of fixed doses of bupropion and ropinirole and iron alone for the treatment of restless legs syndrome (RLS) and to look for the tolerability of these medications. Materials and Methods: Patients diagnosed with RLS were randomly divided into three groups with thirty patients in each group (Group A: Bupropion [300 mg/day], Group B: Ropinirole [0.25–0.5 mg/day], and Group C: Oral iron [150 mg elemental iron] along with folic acid [500 μg]). Each participant was then assessed for severity of RLS, as well as RLS-related quality at the baseline, and thereafter, every 14th day till 6 weeks based on the International Restless Legs Scale (IRLS) severity rating scale and Restless Legs Syndrome Quality of Life (RLSQoL) Questionnaire, respectively. Results: IRLS scores differed significantly from baseline visit to last (F = 4.85; P = 0.01). The interaction between the time x treatment group was significant (F = 10.37; P < 0.001) showing an improvement with the therapy in all the groups. Pair-wise comparison depicted that ropinirole group differed from other two groups in IRLS score (F = 7.06; P = 0.001), which were comparable to each other. Regarding quality of life of these cases, within each group scores differed among all the four visits (F = 5.12; P = 0.002). Unlike IRLS, there was no significant difference among the RLSQOL scores between groups at any point of time (F = 1.2; P = 0.28). Conclusion: RLS severity decreased across time in all three groups; however, the ropinirole treatment was better than the bupropion and iron-folate therapy. Moreover, RLS-related quality of life although improved among all groups, it was comparable among three groups. PMID:27994356

  12. Efficacy of pramipexole for the treatment of primary restless leg syndrome: a systematic review and meta-analysis of randomized clinical trials

    PubMed Central

    Liu, Guang Jian; Wu, Lang; Wang, Song Lin; Xu, Li Li; Chang, Li Ying; Wang, Yun Fu

    2016-01-01

    Purpose The objective of this meta-analysis was to systematically evaluate the efficacy of pramipexole for the treatment of primary moderate to severe RLS. Methods Databases of PubMed, OVID, ScienceDirect, SpringerLink, Thomson Reuters Web of Science, the Cochrane Library, the Wiley Online Library, ArticleFirst, CALIS, Study, CNKI, and WanFang were searched to identify randomized controlled trials (RCTs) investigating pramipexole for the treatment of primary moderate to severe RLS. A meta-analysis was then conducted to pool results. Findings Twelve RCTs involving 3286 participants were included in this study. The average treatment duration was 11.12 (±5.72) weeks/person. The meta-analysis demonstrated that the post-treatment change in the International Restless Leg Syndrome Study Group Rating Scale (IRLS) score of pramipexole group was significantly superior to that of placebo group (weighted mean difference (WMD)=-4.64, 95% confidence intervals (CI) −5.95 to −3.33, n=8). More patients in pramipexole group showed at least a 50% reduction in the IRLS score after treatment (risk ratio [RR]) =1.57, 95% CI 1.43 to 1.73, n=8). In terms of the scores for the Clinical Global Impression of Improvement scale (CGI-I; RR=1.48, 95% CI 1.31 to 1.66, n=11) and the Patient Global Impression scale (PGI; RR=1.54, 95% CI 1.31 to 1.81, n=9), pramipexole group’s treatment outcomes were significantly superior to those of placebo group. In terms of the change in quality of life (WMD=5.39, 95% CI 2.28 to 8.50, n=4), change in daytime tiredness (WMD=-0.61, 95% CI −1.21 to −0.01, n=4), change in the number of periodic limb movements per hour of sleep (WMD=-35.95, 95% CI −56.42 to −15.48, n=3) and change in the quality of sleep (WMD=3.60, 95% CI 1.69 to 5.50, n=6), the treatment outcomes of pramipexole group were significantly superior to those of placebo group. Implications This meta-analysis study indicated that pramipexole could effectively improve the symptoms of primary

  13. An update on pharmacological, pharmacokinetic properties and drug-drug interactions of rotigotine transdermal system in Parkinson's disease and restless legs syndrome.

    PubMed

    Elshoff, Jan-Peer; Cawello, Willi; Andreas, Jens-Otto; Mathy, Francois-Xavier; Braun, Marina

    2015-04-01

    This narrative review reports on the pharmacological and pharmacokinetic properties of rotigotine, a non-ergolinic D₃/D₂/D₁ dopamine receptor agonist approved for the treatment of early- and advanced-stage Parkinson's disease (PD) and moderate to severe restless legs syndrome (RLS). Rotigotine is formulated as a transdermal patch providing continuous drug delivery over 24 h, with a plasma concentration profile similar to that of administration via continuous intravenous infusion. Absolute bioavailability after 24 h transdermal delivery is 37 % of the applied rotigotine dose. Following a single administration of rotigotine transdermal system (24-h patch-on period), most of the absorbed drug is eliminated in urine and feces as sulphated and glucuronidated conjugates within 24 h of patch removal. The drug shows a high apparent volume of distribution (>2500 L) and a total body clearance of 300-600 L/h. Rotigotine transdermal system provides dose-proportional pharmacokinetics up to supratherapeutic dose rates of 24 mg/24 h, with steady-state plasma drug concentrations attained within 1-2 days of daily dosing. The pharmacokinetics of rotigotine transdermal patch are similar in healthy subjects, patients with early- or advanced-stage PD, and patients with RLS when comparing dose-normalized area under the plasma concentration-time curve (AUC) and maximum plasma drug concentration (Cmax), as well as half-life and other pharmacokinetic parameters. Also, it is not influenced in a relevant manner by age, sex, ethnicity, advanced renal insufficiency, or moderate hepatic impairment. No clinically relevant drug-drug interactions were observed following co-administration of rotigotine with levodopa/carbidopa, domperidone, or the CYP450 inhibitors cimetidine or omeprazole. Also, pharmacodynamics and pharmacokinetics of an oral hormonal contraceptive were not influenced by rotigotine co-administration. Rotigotine was generally well tolerated, with an adverse event profile

  14. Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran

    PubMed Central

    Rahmani, Arash; Shafieesabet, Mahdiyeh; Soori, Mahshid; Delbari, Ahmad; Motamed, Mohammad Reza; Lökk, Johan

    2017-01-01

    Background Discrepancies have been reported in the prevalence rate of restless legs syndrome (RLS) among different ethnic groups and geographic populations. Furthermore, there are disagreements on determinant factors and associated comorbidities of RLS. We aimed to estimate prevalence of RLS and investigate its associated comorbid conditions and risk factors in a large population-based door-to-door survey. Methods Following a multistage random sampling from the households lived in 22 urban districts of Tehran, Iran, 19176 participants with ≥30 years of age were recruited. Trained surveyors filled study checklist consisting of baseline characteristics, risk factors and comorbidity profile and the International RLS Study Group (IRLSSG) diagnostic criteria through face-to-face interviews. Results In total, 1580 individuals were positively screened for RLS resulting in a standardized prevalence rate of 60.0/1000. There was a gradual increase in RLS prevalence by advancing age, however, sex difference disappeared after adjustment. Parkinsonism [adjusted odds’ ratio (adj-OR) = 7.4 (95% CI: 5.3–10.4)], peripheral neuropathy [adj-OR = 3.7 (95% CI: 3.3–4.1)], subjective cognitive impairment (SCI) [adj-OR = 3.1 (95% CI: 2.7–3.4)], acting out dreams [adj-OR = 2.8 (95% CI: 2.5–3.2)], hyposmia [adj-OR = 2.5 (95% CI: 2.2–2.9)], active smoking [adj-OR = 1.5 (95% CI: 1.3–1.9)] and additional number of cardiometabolic diseases associated with higher risk of RLS [adj-OR = 1.6 (95% CI: 1.2–2.3)]. Conclusion Our findings showed that neuro-cognitive co-morbidities such as parkinsonism, peripheral neuropathy, SCI, acting out dreams and hyposmia as well as cardio-metabolic risk factors and diseases were independent determinants of RLS. It is recommended to screen individuals with either these comorbid conditions for RLS or the ones with RLS for the accompanying diseases. PMID:28212408

  15. Homelessness, Restlessness and Diasporic Poetry

    ERIC Educational Resources Information Center

    Kizel, Arie

    2010-01-01

    Can poetry be Diasporic? Can poetry free itself from the shackles of conformism? Can it be independent and divergent, and not seek a home? Is it capable of mustering its inner strengths and living without being enlisted by a collective that accords it power? This article argues that poetry is essentially dialectic. It has little vitality without…

  16. Detection of precursory slips on a fault by the quiescence and activation of seismicity relative to the ETAS model and by the anomalous trend of the geodetic time series of distances between GPS stations around the fault

    NASA Astrophysics Data System (ADS)

    Ogata, Y.

    2006-12-01

    This paper is concerned with the detection of precursory slip on a rupturing fault, supported by both seismic and geodetic records. Basically, the detection relies on the principle that, assuming precursory slip on the rupturing fault, the seismic activity around the fault should be enhanced or reduced in the zones where increment of the Coulomb failure stress (CFS) is positive or negative, respectively. However, any occurring event also affects the stress changes in neighboring regions, which can trigger further aftershock clusters. Whereas such stress transfers are too difficult to be computed precisely, due to the unknown complex fault system, the ordinary short-term occurrence rate of earthquakes in a region is easily predicted using the ETAS model of triggering seismicity; and any anomalous seismic activity, such as quiescence and activation, can be quantified by identifying a significant deviation from the predicted rate. Such anomalies are revealed to have occurred during several years leading up to the 2004 Chuetsu Earthquake of M6.8, central Honshu, and also the 2005 Western Fukuoka-Ken-Oki Earthquake of M7.0, Kyushu, Japan. Quiescence and activation in the regions coincided with negative and positive increments of the CFS, respectively, and were probably transferred from possible aseismic slips on the focal fault plane. Such slips are further supported by transient crustal movement around the source preceding the rupture. Time series records of the baseline distances between the permanent GPS stations deviated from the predicted trends, with the deviations consistent with the coseismic horizontal displacements of the stations due to these earthquakes. References Ogata, Y. (2006) Report of the Coordinating Committee for Earthquake Prediction, 76 (to appear, in Japanese).

  17. Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

    PubMed Central

    Sawanyawisuth, Kittisak; Palinkas, Lawrence A.; Ancoli-Israel, Sonia; Dimsdale, Joel E.; Loredo, José S.

    2013-01-01

    Study Objectives: To investigate the prevalence and predictors of RLS in Hispanics of Mexican descent (HMD) and non-Hispanic whites (NHW). Design: A population-based random digit dialing telephone questionnaire. Setting: San Diego County California Participants: 1,754 HMD and 1,913 NHW adults ≥ 18 years of age able to participate in a telephone interview in English or Spanish. Interventions: None. Measurements and Results: RLS was defined by the presence of all 4 criteria of the International Restless Legs Study Group. Sleepiness was measured by the Epworth Sleepiness Scale. Acculturation was evaluated using the Short Acculturation Scale for Hispanics. Risk factors for RLS were by self-report. The survey was conducted in the subject's language of choice. RLS prevalence was significantly lower in HMD than in NHW (14.4% vs.18.3%, p = 0.002). High acculturation HMD had a significantly greater RLS prevalence than the low acculturation group (17.4% vs. 12.8%, p = 0.008). Predictors of RLS varied between HMD and NHW. Female gender (OR 1.40, 95% CI 1.04, 1.90, p = 0.027), smoking (OR 1.82, 95% CI 1.27, 2.61, p = 0.001), and acculturation (OR 1.47, 95% CI 1.10, 1.97, p = 0.009) were independent predictors of RLS in HMD, while only older age (OR 1.01, 95% CI 1.0, 1.02) was an independent predictor of RLS for NHW. Conclusion: The prevalence of RLS was significantly lower in HMD than in NHW, and significantly greater in high acculturation HMD. Our data suggest that risk factors for RLS vary by race/ethnicity and acculturation is an independent risk for RLS in HMD. Citation: Sawanyawisuth K; Palinkas LA; Ancoli-Israel S; Dimsdale JE; Loredo JS. Ethnic differences in the prevalence and predictors of restless legs syndrome between Hispanics of Mexican descent and non-Hispanic whites in San Diego county: a population-based study. J Clin Sleep Med 2013;9(1):47-53. PMID:23319904

  18. Comparison of the recently proposed super-Marx generator approach to thermonuclear ignition with the deuterium-tritium laser fusion-fission hybrid concept by the Lawrence Livermore National Laboratory

    SciTech Connect

    Winterberg, F.

    2009-01-01

    The recently proposed super-Marx generator pure deuterium microdetonation ignition concept is compared to the Lawrence Livermore National Ignition Facility (NIF) Laser deuterium-tritium fusion-fission hybrid concept (LIFE). In a super-Marx generator, a large number of ordinary Marx generators charge up a much larger second stage ultrahigh voltage Marx generator from which for the ignition of a pure deuterium microexplosion an intense GeV ion beam can be extracted. Typical examples of the LIFE concept are a fusion gain of 30 and a fission gain of 10, making up a total gain of 300, with about ten times more energy released into fission as compared to fusion. This means the substantial release of fission products, as in fissionless pure fission reactors. In the super-Marx approach for the ignition of pure deuterium microdetonation, a gain of the same magnitude can, in theory, be reached. If feasible, the super-Marx generator deuterium ignition approach would make lasers obsolete as a means for the ignition of thermonuclear microexplosions.

  19. Comparison of the recently proposed super-Marx generator approach to thermonuclear ignition with the deuterium-tritium laser fusion-fission hybrid concept by the Lawrence Livermore National Laboratory

    DOE PAGES

    Winterberg, F.

    2009-01-01

    The recently proposed super-Marx generator pure deuterium microdetonation ignition concept is compared to the Lawrence Livermore National Ignition Facility (NIF) Laser deuterium-tritium fusion-fission hybrid concept (LIFE). In a super-Marx generator, a large number of ordinary Marx generators charge up a much larger second stage ultrahigh voltage Marx generator from which for the ignition of a pure deuterium microexplosion an intense GeV ion beam can be extracted. Typical examples of the LIFE concept are a fusion gain of 30 and a fission gain of 10, making up a total gain of 300, with about ten times more energy released into fissionmore » as compared to fusion. This means the substantial release of fission products, as in fissionless pure fission reactors. In the super-Marx approach for the ignition of pure deuterium microdetonation, a gain of the same magnitude can, in theory, be reached. If feasible, the super-Marx generator deuterium ignition approach would make lasers obsolete as a means for the ignition of thermonuclear microexplosions.« less

  20. The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults—An Update for 2012: Practice Parameters with an Evidence-Based Systematic Review and Meta-Analyses

    PubMed Central

    Aurora, R. Nisha; Kristo, David A.; Bista, Sabin R.; Rowley, James A.; Zak, Rochelle S.; Casey, Kenneth R.; Lamm, Carin I.; Tracy, Sharon L.; Rosenberg, Richard S.

    2012-01-01

    A systematic literature review and meta-analyses (where appropriate) were performed to update the previous AASM practice parameters on the treatments, both dopaminergic and other, of RLS and PLMD. A considerable amount of literature has been published since these previous reviews were performed, necessitating an update of the corresponding practice parameters. Therapies with a STANDARD level of recommendation include pramipexole and ropinirole. Therapies with a GUIDELINE level of recommendation include levodopa with dopa decarboxylase inhibitor, opioids, gabapentin enacarbil, and cabergoline (which has additional caveats for use). Therapies with an OPTION level of recommendation include carbamazepine, gabapentin, pregabalin, clonidine, and for patients with low ferritin levels, iron supplementation. The committee recommends a STANDARD AGAINST the use of pergolide because of the risks of heart valve damage. Therapies for RLS secondary to ESRD, neuropathy, and superficial venous insufficiency are discussed. Lastly, therapies for PLMD are reviewed. However, it should be mentioned that because PLMD therapy typically mimics RLS therapy, the primary focus of this review is therapy for idiopathic RLS. Citation: Aurora RN; Kristo DA; Bista SR; Rowley JA: Zak RS; Casey KR; Lamm CI; Tracy SL; Rosenberg RS. The treatment of restless legs syndrome and periodic limb movement disorder in adults—an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses. SLEEP 2012;35(8):1039-1062. PMID:22851801