Statistical discovery of site inter-dependencies in sub-molecular hierarchical protein structuring.

PubMed

Durston, Kirk K; Chiu, David Ky; Wong, Andrew Kc; Li, Gary Cl

2012-07-13

Much progress has been made in understanding the 3D structure of proteins using methods such as NMR and X-ray crystallography. The resulting 3D structures are extremely informative, but do not always reveal which sites and residues within the structure are of special importance. Recently, there are indications that multiple-residue, sub-domain structural relationships within the larger 3D consensus structure of a protein can be inferred from the analysis of the multiple sequence alignment data of a protein family. These intra-dependent clusters of associated sites are used to indicate hierarchical inter-residue relationships within the 3D structure. To reveal the patterns of associations among individual amino acids or sub-domain components within the structure, we apply a k-modes attribute (aligned site) clustering algorithm to the ubiquitin and transthyretin families in order to discover associations among groups of sites within the multiple sequence alignment. We then observe what these associations imply within the 3D structure of these two protein families. The k-modes site clustering algorithm we developed maximizes the intra-group interdependencies based on a normalized mutual information measure. The clusters formed correspond to sub-structural components or binding and interface locations. Applying this data-directed method to the ubiquitin and transthyretin protein family multiple sequence alignments as a test bed, we located numerous interesting associations of interdependent sites. These clusters were then arranged into cluster tree diagrams which revealed four structural sub-domains within the single domain structure of ubiquitin and a single large sub-domain within transthyretin associated with the interface among transthyretin monomers. In addition, several clusters of mutually interdependent sites were discovered for each protein family, each of which appear to play an important role in the molecular structure and/or function. Our results demonstrate that the method we present here using a k-modes site clustering algorithm based on interdependency evaluation among sites obtained from a sequence alignment of homologous proteins can provide significant insights into the complex, hierarchical inter-residue structural relationships within the 3D structure of a protein family.

Hydrodynamic Stability Analysis of Multi-jet Effects in Swirling Jet Combustors

NASA Astrophysics Data System (ADS)

Emerson, Benjamin; Lieuwen, Tim

2016-11-01

Many practical combustion devices use multiple swirling jets to stabilize flames. However, much of the understanding of swirling jet dynamics has been generated from experimental and computational studies of single reacting, swirling jets. A smaller body of literature has begun to explore the effects of multi-jet systems and the role of jet-jet interactions on the macro-system dynamics. This work uses local temporal and spatio-temporal stability analyses to isolate the hydrodynamic interactions of multiple reacting, swirling jets, characterized by jet diameter, D, and spacing, L. The results first identify the familiar helical modes in the single jet. Comparison to the multi-jet configuration reveals these same familiar modes simultaneously oscillating in each of the jets. Jet-jet interaction is mostly limited to a spatial synchronization of each jet's oscillations at the jet spacing values analyzed here (L/D =3.5). The presence of multiple jets vs a single jet has little influence on the temporal and absolute growth rates. The biggest difference between the single and multi-jet configurations is the presence of nearly degenerate pairs of hydrodynamic modes in the multi-jet case, with one mode dominated by oscillations in the inner jet, and the other in the outer jets. The close similarity between the single and multi-jet hydrodynamics lends insight into experiments from our group.

Observation, Identification, and Impact of Multi-Modal Plasma Responses to Applied Magnetic Perturbations

NASA Astrophysics Data System (ADS)

Logan, Nikolas

2015-11-01

Experiments on DIII-D have demonstrated that multiple kink modes with comparable amplitudes can be driven by applied nonaxisymmetric fields with toroidal mode number n=2, in good agreement with ideal MHD models. In contrast to a single-mode model, the structure of the response measured using poloidally distributed magnetic sensors changes when varying the applied poloidal spectrum. This is most readily evident in that different spectra of applied fields can independently excite inboard and outboard magnetic responses, which are identified as distinct plasma modes by IPEC modeling. The outboard magnetic response is correlated with the plasma pressure and consistent with the long wavelength perturbations of the least stable, pressure driven kinks calculated by DCON and used in IPEC. The models show the structure of the pressure driven modes extends throughout the bad curvature region and into the plasma core. The inboard plasma response is correlated with the edge current profile and requires the inclusion of multiple kink modes with greater stability, including opposite helicity modes, to replicate the experimental observations in the models. IPEC reveals the resulting mode structure to be highly localized in the plasma edge. Scans of the applied spectrum show this response induces the transport that influences the density pump-out, as well as the toroidal rotation drag observed in experiment and modeled using PENT. The classification of these two mode types establishes a new multi-modal paradigm for n=2 plasma response and guides the understanding needed to optimize 3D fields for independent control of stability and transport. Supported by US DOE contract DE-AC02-09CH11466.

Global resilience analysis of water distribution systems.

PubMed

Diao, Kegong; Sweetapple, Chris; Farmani, Raziyeh; Fu, Guangtao; Ward, Sarah; Butler, David

2016-12-01

Evaluating and enhancing resilience in water infrastructure is a crucial step towards more sustainable urban water management. As a prerequisite to enhancing resilience, a detailed understanding is required of the inherent resilience of the underlying system. Differing from traditional risk analysis, here we propose a global resilience analysis (GRA) approach that shifts the objective from analysing multiple and unknown threats to analysing the more identifiable and measurable system responses to extreme conditions, i.e. potential failure modes. GRA aims to evaluate a system's resilience to a possible failure mode regardless of the causal threat(s) (known or unknown, external or internal). The method is applied to test the resilience of four water distribution systems (WDSs) with various features to three typical failure modes (pipe failure, excess demand, and substance intrusion). The study reveals GRA provides an overview of a water system's resilience to various failure modes. For each failure mode, it identifies the range of corresponding failure impacts and reveals extreme scenarios (e.g. the complete loss of water supply with only 5% pipe failure, or still meeting 80% of demand despite over 70% of pipes failing). GRA also reveals that increased resilience to one failure mode may decrease resilience to another and increasing system capacity may delay the system's recovery in some situations. It is also shown that selecting an appropriate level of detail for hydraulic models is of great importance in resilience analysis. The method can be used as a comprehensive diagnostic framework to evaluate a range of interventions for improving system resilience in future studies. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Nonlinear force dependence on optically bound micro-particle arrays in the evanescent fields of fundamental and higher order microfibre modes

PubMed Central

Maimaiti, Aili; Holzmann, Daniela; Truong, Viet Giang; Ritsch, Helmut; Nic Chormaic, Síle

2016-01-01

Particles trapped in the evanescent field of an ultrathin optical fibre interact over very long distances via multiple scattering of the fibre-guided fields. In ultrathin fibres that support higher order modes, these interactions are stronger and exhibit qualitatively new behaviour due to the coupling of different fibre modes, which have different propagation wave-vectors, by the particles. Here, we study one dimensional longitudinal optical binding interactions of chains of 3 μm polystyrene spheres under the influence of the evanescent fields of a two-mode microfibre. The observation of long-range interactions, self-ordering and speed variation of particle chains reveals strong optical binding effects between the particles that can be modelled well by a tritter scattering-matrix approach. The optical forces, optical binding interactions and the velocity of bounded particle chains are calculated using this method. Results show good agreement with finite element numerical simulations. Experimental data and theoretical analysis show that higher order modes in a microfibre offer a promising method to not only obtain stable, multiple particle trapping or faster particle propulsion speeds, but that they also allow for better control over each individual trapped object in particle ensembles near the microfibre surface. PMID:27451935

Infrared video tracking of Anopheles gambiae at insecticide-treated bed nets reveals rapid decisive impact after brief localised net contact

PubMed Central

Parker, Josephine E.A.; Angarita-Jaimes, Natalia; Abe, Mayumi; Towers, Catherine E.; Towers, David; McCall, Philip J.

2015-01-01

Long-lasting insecticidal bed nets (LLINs) protect humans from malaria transmission and are fundamental to malaria control worldwide, but little is known of how mosquitoes interact with nets. Elucidating LLIN mode of action is essential to maintain or improve efficacy, an urgent need as emerging insecticide resistance threatens their future. Tracking multiple free-flying Anopheles gambiae responding to human-occupied bed nets in a novel large-scale system, we characterised key behaviours and events. Four behavioural modes with different levels of net contact were defined: swooping, visiting, bouncing and resting. Approximately 75% of all activity occurred at the bed net roof where multiple brief contacts were focussed above the occupant’s torso. Total flight and net contact times were lower at LLINs than untreated nets but the essential character of the response was unaltered. LLINs did not repel mosquitoes but impacted rapidly: LLIN contact of less than 1 minute per mosquito during the first ten minutes reduced subsequent activity; after thirty minutes, activity at LLINs was negligible. Velocity measurements showed that mosquitoes detected nets, including unbaited untreated nets, prior to contact. This is the most complete characterisation of mosquito-LLIN interactions to date, and reveals many aspects of LLIN mode of action, important for developing the next generation of LLINs. PMID:26323965

"Multiple partial recognitions in dynamic equilibrium" in the binding sites of proteins form the molecular basis of promiscuous recognition of structurally diverse ligands.

PubMed

Kohda, Daisuke

2018-04-01

Promiscuous recognition of ligands by proteins is as important as strict recognition in numerous biological processes. In living cells, many short, linear amino acid motifs function as targeting signals in proteins to specify the final destination of the protein transport. In general, the target signal is defined by a consensus sequence containing wild-characters, and hence represented by diverse amino acid sequences. The classical lock-and-key or induced-fit/conformational selection mechanism may not cover all aspects of the promiscuous recognition. On the basis of our crystallographic and NMR studies on the mitochondrial Tom20 protein-presequence interaction, we proposed a new hypothetical mechanism based on "a rapid equilibrium of multiple states with partial recognitions". This dynamic, multiple recognition mode enables the Tom20 receptor to recognize diverse mitochondrial presequences with nearly equal affinities. The plant Tom20 is evolutionally unrelated to the animal Tom20 in our study, but is a functional homolog of the animal/fungal Tom20. NMR studies by another research group revealed that the presequence binding by the plant Tom20 was not fully explained by simple interaction modes, suggesting the presence of a similar dynamic, multiple recognition mode. Circumstantial evidence also suggested that similar dynamic mechanisms may be applicable to other promiscuous recognitions of signal peptides by the SRP54/Ffh and SecA proteins.

Asynchronous partial contact motion due to internal resonance in multiple degree-of-freedom rotordynamics

NASA Astrophysics Data System (ADS)

Shaw, A. D.; Champneys, A. R.; Friswell, M. I.

2016-08-01

Sudden onset of violent chattering or whirling rotor-stator contact motion in rotational machines can cause significant damage in many industrial applications. It is shown that internal resonance can lead to the onset of bouncing-type partial contact motion away from primary resonances. These partial contact limit cycles can involve any two modes of an arbitrarily high degree-of-freedom system, and can be seen as an extension of a synchronization condition previously reported for a single disc system. The synchronization formula predicts multiple drivespeeds, corresponding to different forms of mode-locked bouncing orbits. These results are backed up by a brute-force bifurcation analysis which reveals numerical existence of the corresponding family of bouncing orbits at supercritical drivespeeds, provided the damping is sufficiently low. The numerics reveal many overlapping families of solutions, which leads to significant multi-stability of the response at given drive speeds. Further, secondary bifurcations can also occur within each family, altering the nature of the response and ultimately leading to chaos. It is illustrated how stiffness and damping of the stator have a large effect on the number and nature of the partial contact solutions, illustrating the extreme sensitivity that would be observed in practice.

Using multi-ring structure for suppression of mode competition in stable single-longitudinal-mode erbium fiber laser

NASA Astrophysics Data System (ADS)

Yeh, Chien-Hung; Huang, Tzu-Jung; Yang, Zi-Qing; Chow, Chi-Wai

2017-12-01

In this demonstration, a stable and tunable single-longitudinal-mode (SLM) erbium-doped fiber (EDF) laser with multiple-ring configuration is proposed and investigated. The proposed compound-ring structure can create different free spectrum ranges (FSRs) to result in the mode-filter effect based on the Vernier effect for suppressing the other modes. Additionally, the output stabilization of power and wavelength in the proposed EDF multiple-ring laser are also discussed.

Theoretical study of modulated multi-layer SPR device for improved refractive index sensing

NASA Astrophysics Data System (ADS)

Mohapatra, Saswat; Moirangthem, Rakesh S.

2018-02-01

In the present work, a theoretical investigation of Surface Plasmon Resonance (SPR) properties of a multilayer film (Au-SiO2-Au) coated on a glass prism is being carried out. In this multilayer structure, each interface corresponds to multiple SPR modes. To obtain the maximum reflection dips in the SPR modes, the thickness of SiO2 layer is optimized by varying it from 100-600 nm. Our calculation also reveals that SPR mode corresponding to Au-ambient interface is very sensitive to the changes in the surrounding medium, least affecting other SPR modes. The sensing performance of the proposed nano-plasmonic sensor is theoretically calculated using bulk refractive index sensing. Such multilayer SPR sensing device has advantages over conventional SPR devices in terms of their bulk sensitivity and self-referencing, claiming itself as a potential candidate for the development of highly sensitive biological sensor.

Vector nature of multi-soliton patterns in a passively mode-locked figure-eight fiber laser.

PubMed

Ning, Qiu-Yi; Liu, Hao; Zheng, Xu-Wu; Yu, Wei; Luo, Ai-Ping; Huang, Xu-Guang; Luo, Zhi-Chao; Xu, Wen-Cheng; Xu, Shan-Hui; Yang, Zhong-Min

2014-05-19

The vector nature of multi-soliton dynamic patterns was investigated in a passively mode-locked figure-eight fiber laser based on the nonlinear amplifying loop mirror (NALM). By properly adjusting the cavity parameters such as the pump power level and intra-cavity polarization controllers (PCs), in addition to the fundamental vector soliton, various vector multi-soliton regimes were observed, such as the random static distribution of vector multiple solitons, vector soliton cluster, vector soliton flow, and the state of vector multiple solitons occupying the whole cavity. Both the polarization-locked vector solitons (PLVSs) and the polarization-rotating vector solitons (PRVSs) were observed for fundamental soliton and each type of multi-soliton patterns. The obtained results further reveal the fundamental physics of multi-soliton patterns and demonstrate that the figure-eight fiber lasers are indeed a good platform for investigating the vector nature of different soliton types.

Stable Isotope-Assisted Metabolic Profiling Reveals Growth Mode Dependent Differential Metabolism and Multiple Catabolic Pathways of l-Phenylalanine in Rubrivivax benzoatilyticus JA2.

PubMed

Mekala, Lakshmi Prasuna; Mohammed, Mujahid; Chintalapati, Sasikala; Chintalapati, Venkata Ramana

2018-01-05

Anoxygenic phototrophic bacteria are metabolically versatile and survive under different growth modes using diverse organic compounds, yet their metabolic diversity is largely unexplored. In the present study, we employed stable-isotope-assisted metabolic profiling to unravel the l-phenylalanine catabolism in Rubrivivax benzoatilyticus JA2 under varying growth modes. Strain JA2 grows under anaerobic and aerobic conditions by utilizing l-phenylalanine as a nitrogen source. Furthermore, ring-labeled 13 C 6 -phenylalanine feeding followed by liquid chromatography-mass spectrometry exometabolite profiling revealed 60 labeled metabolic features (M + 6, M + 12, and M + 18) derived solely from l-phenylalanine, of which 11 were identified, 7 putatively identified, and 42 unidentified under anaerobic and aerobic conditions. However, labeled metabolites were significantly higher in aerobic compared to anaerobic conditions. Furthermore, detected metabolites and enzyme activities indicated multiple l-phenylalanine catabolic routes mainly Ehrlich, homogentisate-dependent melanin, benzenoid, and unidentified pathways operating under anaerobic and aerobic conditions in strain JA2. Interestingly, the study indicated l-phenylalanine-dependent and independent benzenoid biosynthesis in strain JA2 and a differential flux of l-phenylalanine to Ehrlich and benzenoid pathways under anaerobic and aerobic conditions. Additionally, unidentified labeled metabolites strongly suggest the presence of unknown phenylalanine catabolic routes in strain JA2. Overall, the study uncovered the l-phenylalanine catabolic diversity in strain JA2 and demonstrated the potential of stable isotope-assisted metabolomics in unraveling the hidden metabolic repertoire.

A theory of growing crystalline nanorods - Mode I

NASA Astrophysics Data System (ADS)

Du, Feng; Huang, Hanchen

2018-08-01

Nanorods grow in two possible modes during physical vapor deposition (PVD). In mode I, monolayer surface steps dictate the diameter of nanorods. In mode II, multiple-layer surface steps dictate the diameter, which is the smallest possible under physical vapor deposition [5,10]. This paper reports closed-form theories of terrace lengths and nanorod diameter during the growth in mode I, as a function of deposition conditions. The accompanying lattice kinetic Monte Carlo simulations verify these theories. This study reveals that (1) quasi-steady growth exists for each set of nanorod growth conditions, and (2) the characteristic length scales, including terrace lengths and nanorod diameter at the quasi-steady state, depend on the deposition conditions - deposition rate F, substrate temperature T, and incidence angle θ - only as a function of l2D/tan θ, with l2 D = 2(v2 D/Fcosθ) 1/3 as a diffusion-limited length scale and v2D as the atomic diffusion jump rate over monolayer surface steps.

Phenomenology of beam driven modes in the field reversed configuration

NASA Astrophysics Data System (ADS)

Magee, Richard; Bolte, Nathan; Clary, Ryan; Necas, Ales; Korepanov, Sergey; Smirnov, Artem; Thompson, Matthew; Tajima, Toshiki; THE TAE Team

2016-10-01

The C-2U experiment offers a unique plasma environment combining a high beta field reversed configuration (FRC) embedded in a low beta magnetic mirror with high power neutral beam injection. The beams are injected tangentially into a modest magnetic field so that the orbits of the resulting fast ions encircle the entire plasma. These large orbit particles sustain and stabilize the plasma and suppress turbulence. Measurements of magnetic fluctuations at the edge of the plasma reveal the presence of three coherent beam driven modes: a low frequency, chirping mode, a mode near the ion cyclotron frequency, and a high frequency compressional Alfven mode. Remarkably, none of these modes are observed to have a deleterious effect on global plasma confinement. In fact, the cyclotron mode has the beneficial effect of dramatically enhancing the DD fusion reaction rate by drawing a trail from the plasma ion energy distribution on a sub-collisional timescale. In this presentation, we experimentally characterize the beam driven modes in the C-2U FRC with data from multiple diagnostics including magnetics, spectroscopy, neutral particle analyzers and fusion product diagnostics. Results are compared to a particle-in-cell simulation in a simplified geometry.

Combination of DTI and fMRI reveals the white matter changes correlating with the decline of default-mode network activity in Alzheimer's disease

NASA Astrophysics Data System (ADS)

Wu, Xianjun; Di, Qian; Li, Yao; Zhao, Xiaojie

2009-02-01

Recently, evidences from fMRI studies have shown that there was decreased activity among the default-mode network in Alzheimer's disease (AD), and DTI researches also demonstrated that demyelinations exist in white matter of AD patients. Therefore, combining these two MRI methods may help to reveal the relationship between white matter damages and alterations of the resting state functional connectivity network. In the present study, we tried to address this issue by means of correlation analysis between DTI and resting state fMRI images. The default-mode networks of AD and normal control groups were compared to find the areas with significantly declined activity firstly. Then, the white matter regions whose fractional anisotropy (FA) value correlated with this decline were located through multiple regressions between the FA values and the BOLD response of the default networks. Among these correlating white matter regions, those whose FA values also declined were found by a group comparison between AD patients and healthy elderly control subjects. Our results showed that the areas with decreased activity among default-mode network included left posterior cingulated cortex (PCC), left medial temporal gyrus et al. And the damaged white matter areas correlated with the default-mode network alterations were located around left sub-gyral temporal lobe. These changes may relate to the decreased connectivity between PCC and medial temporal lobe (MTL), and thus correlate with the deficiency of default-mode network activity.

Analyzing the Multiscale Processes in Tropical Cyclone Genesis Associated with African Easterly Waves using the PEEMD. Part I: Downscaling Processes

NASA Astrophysics Data System (ADS)

Wu, Y.; Shen, B. W.; Cheung, S.

2016-12-01

Recent advance in high-resolution global hurricane simulations and visualizations have collectively suggested the importance of both downscaling and upscaling processes in the formation and intensification of TCs. To reveal multiscale processes from massive volume of global data for multiple years, a scalable Parallel Ensemble Empirical Mode Decomposition (PEEMD) method has been developed for the analysis. In this study, the PEEMD is applied to analyzing 10-year (2004-2013) ERA-Interim global 0.750 resolution reanalysis data to explore the role of the downscaling processes in tropical cyclogenesis associated with African Easterly Waves (AEWs). Using the PEEMD, raw data are decomposed into oscillatory Intrinsic Function Modes (IMFs) that represent atmospheric systems of the various length scales and the trend mode that represents a non-oscillatory large scale environmental flow. Among oscillatory modes, results suggest that the third oscillatory mode (IMF3) is statistically correlated with the TC/AEW scale systems. Therefore, IMF3 and trend mode are analyzed in details. Our 10-year analysis shows that more than 50% of the AEW associated hurricanes reveal the association of storms' formation with the significant downscaling shear transfer from the larger-scale trend mode to the smaller scale IMF3. Future work will apply the PEEMD to the analysis of higher-resolution datasets to explore the role of the upscaling processes provided by the convection (or TC) in the development of the TC (or AEW). Figure caption: The tendency for horizontal wind shear for the total winds (black line), IMF3 (blue line), and trend mode (red line) and SLP (black dotted line) along the storm track of Helene (2006).

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, Michael; McNamara, Brian R.; Perimeter Institute for Theoretical Physics, Waterloo

In this study, we present new ultraviolet, optical, and X-ray data on the Phoenix galaxy cluster (SPT-CLJ2344-4243). Deep optical imaging reveals previously undetected filaments of star formation, extending to radii of ~50–100 kpc in multiple directions. Combined UV-optical spectroscopy of the central galaxy reveals a massive (2 × 10 9 M ⊙), young (~4.5 Myr) population of stars, consistent with a time-averaged star formation rate of 610 ± 50 M ⊙ yr –1. We report a strong detection of O vi λλ1032,1038, which appears to originate primarily in shock-heated gas, but may contain a substantial contribution (>1000 M ⊙ yrmore » –1) from the cooling intracluster medium (ICM). We confirm the presence of deep X-ray cavities in the inner ~10 kpc, which are among the most extreme examples of radio-mode feedback detected to date, implying jet powers of 2 – 7 × 10 45 erg s –1. We provide evidence that the active galactic nucleus inflating these cavities may have only recently transitioned from "quasar-mode" to "radio-mode," and may currently be insufficient to completely offset cooling. A model-subtracted residual X-ray image reveals evidence for prior episodes of strong radio-mode feedback at radii of ~100 kpc, with extended "ghost" cavities indicating a prior epoch of feedback roughly 100 Myr ago. This residual image also exhibits significant asymmetry in the inner ~200 kpc (0.15R 500), reminiscent of infalling cool clouds, either due to minor mergers or fragmentation of the cooling ICM. Taken together, these data reveal a rapidly evolving cool core which is rich with structure (both spatially and in temperature), is subject to a variety of highly energetic processes, and yet is cooling rapidly and forming stars along thin, narrow filaments.« less

Multiple Modes of Cell Death Discovered in a Prokaryotic (Cyanobacterial) Endosymbiont

PubMed Central

Zheng, Weiwen; Rasmussen, Ulla; Zheng, Siping; Bao, Xiaodong; Chen, Bin; Gao, Yuan; Guan, Xiong; Larsson, John; Bergman, Birgitta

2013-01-01

Programmed cell death (PCD) is a genetically-based cell death mechanism with vital roles in eukaryotes. Although there is limited consensus on similar death mode programs in prokaryotes, emerging evidence suggest that PCD events are operative. Here we present cell death events in a cyanobacterium living endophytically in the fern Azolla microphylla, suggestive of PCD. This symbiosis is characterized by some unique traits such as a synchronized development, a vertical transfer of the cyanobacterium between plant generations, and a highly eroding cyanobacterial genome. A combination of methods was used to identify cell death modes in the cyanobacterium. Light- and electron microscopy analyses showed that the proportion of cells undergoing cell death peaked at 53.6% (average 20%) of the total cell population, depending on the cell type and host developmental stage. Biochemical markers used for early and late programmed cell death events related to apoptosis (Annexin V-EGFP and TUNEL staining assays), together with visualization of cytoskeleton alterations (FITC-phalloidin staining), showed that all cyanobacterial cell categories were affected by cell death. Transmission electron microscopy revealed four modes of cell death: apoptotic-like, autophagic-like, necrotic-like and autolytic-like. Abiotic stresses further enhanced cell death in a dose and time dependent manner. The data also suggest that dynamic changes in the peptidoglycan cell wall layer and in the cytoskeleton distribution patterns may act as markers for the various cell death modes. The presence of a metacaspase homolog (domain p20) further suggests that the death modes are genetically programmed. It is therefore concluded that multiple, likely genetically programmed, cell death modes exist in cyanobacteria, a finding that may be connected with the evolution of cell death in the plant kingdom. PMID:23822984

Low order models for uncertainty quantification in acoustic propagation problems

NASA Astrophysics Data System (ADS)

Millet, Christophe

2016-11-01

Long-range sound propagation problems are characterized by both a large number of length scales and a large number of normal modes. In the atmosphere, these modes are confined within waveguides causing the sound to propagate through multiple paths to the receiver. For uncertain atmospheres, the modes are described as random variables. Concise mathematical models and analysis reveal fundamental limitations in classical projection techniques due to different manifestations of the fact that modes that carry small variance can have important effects on the large variance modes. In the present study, we propose a systematic strategy for obtaining statistically accurate low order models. The normal modes are sorted in decreasing Sobol indices using asymptotic expansions, and the relevant modes are extracted using a modified iterative Krylov-based method. The statistics of acoustic signals are computed by decomposing the original pulse into a truncated sum of modal pulses that can be described by a stationary phase method. As the low-order acoustic model preserves the overall structure of waveforms under perturbations of the atmosphere, it can be applied to uncertainty quantification. The result of this study is a new algorithm which applies on the entire phase space of acoustic fields.

Scaling Fiber Lasers to Large Mode Area: An Investigation of Passive Mode-Locking Using a Multi-Mode Fiber

PubMed Central

Ding, Edwin; Lefrancois, Simon; Kutz, Jose Nathan; Wise, Frank W.

2011-01-01

The mode-locking of dissipative soliton fiber lasers using large mode area fiber supporting multiple transverse modes is studied experimentally and theoretically. The averaged mode-locking dynamics in a multi-mode fiber are studied using a distributed model. The co-propagation of multiple transverse modes is governed by a system of coupled Ginzburg–Landau equations. Simulations show that stable and robust mode-locked pulses can be produced. However, the mode-locking can be destabilized by excessive higher-order mode content. Experiments using large core step-index fiber, photonic crystal fiber, and chirally-coupled core fiber show that mode-locking can be significantly disturbed in the presence of higher-order modes, resulting in lower maximum single-pulse energies. In practice, spatial mode content must be carefully controlled to achieve full pulse energy scaling. This paper demonstrates that mode-locking performance is very sensitive to the presence of multiple waveguide modes when compared to systems such as amplifiers and continuous-wave lasers. PMID:21731106

Scaling Fiber Lasers to Large Mode Area: An Investigation of Passive Mode-Locking Using a Multi-Mode Fiber.

PubMed

Ding, Edwin; Lefrancois, Simon; Kutz, Jose Nathan; Wise, Frank W

2011-01-01

The mode-locking of dissipative soliton fiber lasers using large mode area fiber supporting multiple transverse modes is studied experimentally and theoretically. The averaged mode-locking dynamics in a multi-mode fiber are studied using a distributed model. The co-propagation of multiple transverse modes is governed by a system of coupled Ginzburg-Landau equations. Simulations show that stable and robust mode-locked pulses can be produced. However, the mode-locking can be destabilized by excessive higher-order mode content. Experiments using large core step-index fiber, photonic crystal fiber, and chirally-coupled core fiber show that mode-locking can be significantly disturbed in the presence of higher-order modes, resulting in lower maximum single-pulse energies. In practice, spatial mode content must be carefully controlled to achieve full pulse energy scaling. This paper demonstrates that mode-locking performance is very sensitive to the presence of multiple waveguide modes when compared to systems such as amplifiers and continuous-wave lasers.

Transition-metal prion protein attachment: Competition with copper

NASA Astrophysics Data System (ADS)

Hodak, Miroslav; Bernholc, Jerry

2012-02-01

Prion protein, PrP, is a protein capable of binding copper ions in multiple modes depending on their concentration. Misfolded PrP is implicated in a group of neurodegenerative diseases, which include ``mad cow disease'' and its human form, variant Creutzfeld-Jacob disease. An increasing amount of evidence suggests that attachment of non-copper metal ions to PrP triggers transformations to abnormal forms similar to those observed in prion diseases. In this work, we use hybrid Kohn-Sham/orbital-free density functional theory simulations to investigate copper replacement by other transition metals that bind to PrP, including zinc, iron and manganese. We consider all known copper binding modes in the N-terminal domain of PrP. Our calculations identify modes most susceptible to copper replacement and reveal metals that can successfully compete with copper for attachment to PrP.

Comparison of Tone Mode Measurements for a Forward Swept and Baseline Rotor Fan

NASA Technical Reports Server (NTRS)

Heidelberg, Laurence J.

2003-01-01

A forward swept fan, designated the Quite High Speed Fan (QHSF), was tested in the NASA Glenn 9- by 15-foot Low Speed Wind Tunnel to investigate its noise reduction relative to a baseline fan of the same aerodynamic performance. The design objective of the QHSF was a 6 dB reduction in Effective Perceived Noise Level relative to the baseline fan at the takeoff condition. The design noise reduction was to be a result of lower levels of multiple pure tone noise due to the forward swept rotor, and lower rotor/stator interaction tone noise from a leaned stator. Although the design 6 dB reduction was observed in far-field measurements, the induct mode measurements revealed the reasons for goals. All of the noise reduction was from the blade passing tone and its harmonics and most of this was unexpectedly from rotor/strut interaction modes. The reason for large differences in rotor/strut noise sources could not be determined with certainty. The reductions in the multiple pure tone noise for the forward swept rotor were not observed. this reduction were not the ones related to the design

Adjustment modes in the trajectory of progressive multiple sclerosis: a qualitative study and conceptual model.

PubMed

Bogosian, Angeliki; Morgan, Myfanwy; Bishop, Felicity L; Day, Fern; Moss-Morris, Rona

2017-03-01

We examined cognitive and behavioural challenges and adaptations for people with progressive multiple sclerosis (MS) and developed a preliminary conceptual model of changes in adjustment over time. Using theoretical sampling, 34 semi-structured interviews were conducted with people with MS. Participants were between 41 and 77 years of age. Thirteen were diagnosed with primary progressive MS and 21 with secondary progressive MS. Data were analysed using a grounded theory approach. Participants described initially bracketing the illness off and carrying on their usual activities but this became problematic as the condition progressed and they employed different adjustment modes to cope with increased disabilities. Some scaled back their activities to live a more comfortable life, others identified new activities or adapted old ones, whereas at times, people disengaged from the adjustment process altogether and resigned to their condition. Relationships with partners, emotional reactions, environment and perception of the environment influenced adjustment, while people were often flexible and shifted among modes. Adjusting to a progressive condition is a fluid process. Future interventions can be tailored to address modifiable factors at different stages of the condition and may involve addressing emotional reactions concealing/revealing the condition and perceptions of the environment.

Co-based amorphous thin films on silicon with soft magnetic properties

NASA Astrophysics Data System (ADS)

Masood, Ansar; McCloskey, P.; Mathúna, Cian Ó.; Kulkarni, S.

2018-05-01

The present work investigates the emergence of multiple modes in the high-frequency permeability spectrum of Co-Zr-Ta-B amorphous thin films. Amorphous thin films of different thicknesses (t=100-530 nm) were deposited by DC magnetron sputtering. Their static and dynamic soft magnetic properties were investigated to explore the presence of multi-magnetic phases in the films. A two-phase magnetic behavior of the thicker films (≥333 nm) was revealed by the in-plane hysteresis loops. Multiple resonance peaks were observed in the high-frequency permeability spectrum of the thicker films. The thickness dependent multiple resonance peaks below the main ferromagnetic resonance (FMR) can be attributed to the two-phase magnetic behaviors of the films.

Control dynamics of interaction quenched ultracold bosons in periodically driven lattices

NASA Astrophysics Data System (ADS)

Mistakidis, Simeon; Schmelcher, Peter; Group of Fundamental Processes in Quantum Physics Team

2016-05-01

The out-of-equilibrium dynamics of ultracold bosons following an interaction quench upon a periodically driven optical lattice is investigated. It is shown that an interaction quench triggers the inter-well tunneling dynamics, while for the intra-well dynamics breathing and cradle-like processes can be generated. In particular, the occurrence of a resonance between the cradle and tunneling modes is revealed. On the other hand, the employed periodic driving enforces the bosons in the mirror wells to oscillate out-of-phase and to exhibit a dipole mode, while in the central well the cloud experiences a breathing mode. The dynamical behaviour of the system is investigated with respect to the driving frequency revealing a resonant behaviour of the intra-well dynamics. To drive the system in a highly non-equilibrium state an interaction quench upon the driving is performed giving rise to admixtures of excitations in the outer wells, an enhanced breathing in the center and an amplification of the tunneling dynamics. As a result of the quench the system experiences multiple resonances between the inter- and intra-well dynamics at different quench amplitudes. Deutsche Forschungsgemeinschaft, SFB 925 ``Light induced dynamics and control of correlated quantum systems''.

Delamination of Composite Cylinders

NASA Astrophysics Data System (ADS)

Davies, Peter; Carlsson, Leif A.

The delamination resistance of filament wound glass/epoxy cylinders has been characterized for a range of winding angles and fracture mode ratios using beam fracture specimens. The results reveal that the delamination fracture resistance increases with increasing winding angle and mode II (shear) fraction (GΠ/G). It was also found that interlaced fiber bundles in the filament wound cylinder wall acted as effective crack arresters in mode I loading. To examine the sensitivity of delamina-tion damage on the strength of the cylinders, external pressure tests were performed on filament-wound glass/epoxy composite cylinders with artificial defects and impact damage. The results revealed that the cylinder strength was insensitive to the presence of single delaminations but impact damage caused reductions in failure pressure. The insensitivity of the failure pressure to a single delamination is attributed to the absence of buckling of the delaminated sublaminates before the cylinder wall collapsed. The impacted cylinders contained multiple delaminations, which caused local reduction in the compressive load capability and reduction in failure pressure. The response of glass/epoxy cylinders was compared to impacted carbon reinforced cylinders. Carbon/epoxy is more sensitive to damage but retains higher implosion resistance while carbon/PEEK shows the opposite trend.

FANNING OUT OF THE SOLAR f-MODE IN THE PRESENCE OF NON-UNIFORM MAGNETIC FIELDS?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Nishant K.; Brandenburg, Axel; Rheinhardt, Matthias, E-mail: nishant@nordita.org

2014-11-01

We show that in the presence of a magnetic field that is varying harmonically in space, the fundamental mode, or f-mode, in a stratified layer is altered in such a way that it fans out in the diagnostic kω diagram, with mode power also within the fan. In our simulations, the surface is defined by a temperature and density jump in a piecewise isothermal layer. Unlike our previous work (Singh et al. 2014), where a uniform magnetic field was considered, here we employ a non-uniform magnetic field together with hydromagnetic turbulence at length scales much smaller than those of themore » magnetic field. The expansion of the f-mode is stronger for fields confined to the layer below the surface. In some of those cases, the kω diagram also reveals a new class of low-frequency vertical stripes at multiples of twice the horizontal wavenumber of the background magnetic field. We argue that the study of the f-mode expansion might be a new and sensitive tool to determine subsurface magnetic fields with azimuthal or other horizontal periodicity.« less

Numerical simulation of the multiple core localized low shear toroidal Alfvenic eigenmodes

NASA Astrophysics Data System (ADS)

Wang, Wenjia; Zhou, Deng; Hu, Youjun; Ming, Yue

2018-03-01

In modern tokamak experiments, scenarios with weak central magnetic shear has been proposed. It is necessary to study the Alfvenic mode activities in such scenarios. Theoretical researches have predicted the multiplicity of core-localized toroidally induced Alfvenic eigenmodes for ɛ/s > 1, where ɛ is the inverse aspect ratio and s is magnetic shear. We numerically investigate the existence of multiplicity of core-localized TAEs and mode characteristics using NOVA code in the present work. We firstly verify the existence of the multiplicity for zero beta plasma and the even mode at the forbidden zone. For finite beta plasma, the mode parities become more distinguishable, and the frequencies of odd modes are close to the upper tip of the continuum, while the frequencies of even modes are close to the lower tip of the continuum. Their frequencies are well separated by the forbidden zone. With the increasing value of ɛ/s, more modes with multiple radial nodes will appear, which is in agreement with theoretical prediction. The discrepancy between theoretical prediction and our numerical simulation is also discussed in the main text.

Information-Theoretical Quantifier of Brain Rhythm Based on Data-Driven Multiscale Representation

PubMed Central

2015-01-01

This paper presents a data-driven multiscale entropy measure to reveal the scale dependent information quantity of electroencephalogram (EEG) recordings. This work is motivated by the previous observations on the nonlinear and nonstationary nature of EEG over multiple time scales. Here, a new framework of entropy measures considering changing dynamics over multiple oscillatory scales is presented. First, to deal with nonstationarity over multiple scales, EEG recording is decomposed by applying the empirical mode decomposition (EMD) which is known to be effective for extracting the constituent narrowband components without a predetermined basis. Following calculation of Renyi entropy of the probability distributions of the intrinsic mode functions extracted by EMD leads to a data-driven multiscale Renyi entropy. To validate the performance of the proposed entropy measure, actual EEG recordings from rats (n = 9) experiencing 7 min cardiac arrest followed by resuscitation were analyzed. Simulation and experimental results demonstrate that the use of the multiscale Renyi entropy leads to better discriminative capability of the injury levels and improved correlations with the neurological deficit evaluation after 72 hours after cardiac arrest, thus suggesting an effective diagnostic and prognostic tool. PMID:26380297

Transition of lasing modes in polymeric opal photonic crystal resonating cavity.

PubMed

Shi, Lan-Ting; Zheng, Mei-Ling; Jin, Feng; Dong, Xian-Zi; Chen, Wei-Qiang; Zhao, Zhen-Sheng; Duan, Xuan-Ming

2016-06-10

We demonstrate the transition of lasing modes in the resonating cavity constructed by polystyrene opal photonic crystals and 7 wt. % tert-butyl Rhodamine B doped polymer film. Both single mode and multiple mode lasing emission are observed from the resonating cavity. The lasing threshold is determined to be 0.81  μJ/pulse for single mode lasing emission and 2.25  μJ/pulse for multiple mode lasing emission. The single mode lasing emission is attributed to photonic lasing resulting from the photonic bandgap effect of the opal photonic crystals, while the multiple mode lasing emission is assigned to random lasing due to the defects in the photonic crystals. The result would benefit the development of low threshold polymeric solid state photonic crystal lasers.

Identifying the Role of Terahertz Vibrations in Metal-Organic Frameworks: From Gate-Opening Phenomenon to Shear-Driven Structural Destabilization

NASA Astrophysics Data System (ADS)

Ryder, Matthew R.; Civalleri, Bartolomeo; Bennett, Thomas D.; Henke, Sebastian; Rudić, Svemir; Cinque, Gianfelice; Fernandez-Alonso, Felix; Tan, Jin-Chong

2014-11-01

We present an unambiguous identification of low-frequency terahertz vibrations in the archetypal imidazole-based metal-organic framework (MOF) materials: ZIF-4, ZIF-7, and ZIF-8, all of which adopt a zeolite-like nanoporous structure. Using inelastic neutron scattering and synchrotron radiation far-infrared absorption spectroscopy, in conjunction with density functional theory (DFT), we have pinpointed all major sources of vibrational modes. Ab initio DFT calculations revealed the complex nature of the collective THz modes, which enable us to establish detailed correlations with experiments. We discover that low-energy conformational dynamics offers multiple pathways to elucidate novel physical phenomena observed in MOFs. New evidence demonstrates that THz modes are intrinsically linked, not only to anomalous elasticity underpinning gate-opening and pore-breathing mechanisms, but also to shear-induced phase transitions and the onset of structural instability.

Understanding Turbulence using Active and Passive Multipoint Measurements in Laboratory Magnetospheres

NASA Astrophysics Data System (ADS)

Mauel, M. E.; Abler, M. C.; Qian, T. M.; Saperstein, A.; Yan, J. R.

2017-10-01

In a laboratory magnetosphere, plasma is confined by a strong dipole magnet, and interchange and entropy mode turbulence can be studied and controlled in near steady-state conditions. Turbulence is dominated by long wavelength modes exhibiting chaotic dynamics, intermitency, and an inverse spectral cascade. Here, we summarize recent results: (i) high-resolution measurement of the frequency-wavenumber power spectrum using Capon's ``maximum likelihood method'', and (ii) direct measurement of the nonlinear coupling of interchange/entropy modes in a turbulent plasma through driven current injection at multiple locations and frequencies. These observations well-characterize plasma turbulence over a broad band of wavelengths and frequencies. Finally, we also discuss the application of these techniques to space-based experiments and observations aimed to reveal the nature of heliospheric and magnetospheric plasma turbulence. Supported by NSF-DOE Partnership in Plasma Science Grant DE-FG02-00ER54585.

Soft collinear effective theory for gravity

NASA Astrophysics Data System (ADS)

Okui, Takemichi; Yunesi, Arash

2018-03-01

We present how to construct a soft collinear effective theory (SCET) for gravity at the leading and next-to-leading powers from the ground up. The soft graviton theorem and decoupling of collinear gravitons at the leading power are manifest from the outset in the effective symmetries of the theory. At the next-to-leading power, certain simple structures of amplitudes, which are completely obscure in Feynman diagrams of the full theory, are also revealed, which greatly simplifies calculations. The effective Lagrangian is highly constrained by effectively multiple copies of diffeomorphism invariance that are inevitably present in gravity SCET due to mode separation, an essential ingredient of any SCET. Further explorations of effective theories of gravity with mode separation may shed light on Lagrangian-level understandings of some of the surprising properties of gravitational scattering amplitudes. A gravity SCET with an appropriate inclusion of Glauber modes may serve as a powerful tool for studying gravitational scattering in the Regge limit.

Finite-Temperature Hydrogen Adsorption/Desorption Thermodynamics Driven by Soft Vibration Modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woo, Sung-Jae; Lee, Eui-Sup; Yoon, Mina

2013-01-01

It is widely accepted that room-temperature hydrogen storage on nanostructured or porous materials requires enhanced dihydrogen adsorption. In this work we reveal that room-temperature hydrogen storage is possible not only by the enhanced adsorption, but also by making use of the vibrational free energy from soft vibration modes. These modes exist for example in the case of metallo-porphyrin-incorporated graphenes (M-PIGs) with out-of-plane ( buckled ) metal centers. There, the in-plane potential surfaces are flat because of multiple-orbital-coupling between hydrogen molecules and the buckled-metal centers. This study investigates the finite-temperature adsorption/desorption thermodynamics of hydrogen molecules adsorbed on M-PIGs by employing first-principlesmore » total energy and vibrational spectrum calculations. Our results suggest that the current design strategy for room-temperature hydrogen storage materials should be modified by explicitly taking finite-temperature vibration thermodynamics into account.« less

Mode-coupling of interaction quenched ultracold bosons in periodically driven lattices

NASA Astrophysics Data System (ADS)

Mistakidis, Simeon; Schmelcher, Peter

2016-05-01

The out-of-equilibrium dynamics of interaction quenched finite ultracold bosonic ensembles in periodically driven one-dimensional optical lattices is investigated. As a first attempt a brief analysis of the dynamics caused exclusively by the periodically driven lattice is presented and the induced low-lying modes are introduced. It is shown that the periodic driving enforces the bosons in the outer wells to exhibit out-of-phase dipole-like modes, while in the central well the cloud experiences a local-breathing mode. The dynamical behavior of the system is investigated with respect to the driving frequency, revealing a resonant-like behavior of the intra-well dynamics. Subsequently, we drive the system to a highly non-equilibrium state by performing an interaction quench upon the periodically driven lattice. This protocol gives rise to admixtures of excitations in the outer wells, an enhanced breathing in the center and an amplification of the tunneling dynamics. As a result (of the quench) the system experiences multiple resonances between the inter- and intra-well dynamics at different quench amplitudes. Finally, our study reveals that the position of the resonances can be adjusted e.g. via the driving frequency or the atom number manifesting their many-body nature. Deutsche Forschungsgemeinschaft (DFG) in the framework of the SFB 925 ``Light induced dynamics and control of correlated quantum systems''.

Tensor Analysis Reveals Distinct Population Structure that Parallels the Different Computational Roles of Areas M1 and V1

PubMed Central

Ryu, Stephen I.; Shenoy, Krishna V.; Cunningham, John P.; Churchland, Mark M.

2016-01-01

Cortical firing rates frequently display elaborate and heterogeneous temporal structure. One often wishes to compute quantitative summaries of such structure—a basic example is the frequency spectrum—and compare with model-based predictions. The advent of large-scale population recordings affords the opportunity to do so in new ways, with the hope of distinguishing between potential explanations for why responses vary with time. We introduce a method that assesses a basic but previously unexplored form of population-level structure: when data contain responses across multiple neurons, conditions, and times, they are naturally expressed as a third-order tensor. We examined tensor structure for multiple datasets from primary visual cortex (V1) and primary motor cortex (M1). All V1 datasets were ‘simplest’ (there were relatively few degrees of freedom) along the neuron mode, while all M1 datasets were simplest along the condition mode. These differences could not be inferred from surface-level response features. Formal considerations suggest why tensor structure might differ across modes. For idealized linear models, structure is simplest across the neuron mode when responses reflect external variables, and simplest across the condition mode when responses reflect population dynamics. This same pattern was present for existing models that seek to explain motor cortex responses. Critically, only dynamical models displayed tensor structure that agreed with the empirical M1 data. These results illustrate that tensor structure is a basic feature of the data. For M1 the tensor structure was compatible with only a subset of existing models. PMID:27814353

Passively aligned multichannel fiber-pigtailing of planar integrated optical waveguides

NASA Astrophysics Data System (ADS)

Kremmel, Johannes; Lamprecht, Tobias; Crameri, Nino; Michler, Markus

2017-02-01

A silicon device to simplify the coupling of multiple single-mode fibers to embedded single-mode waveguides has been developed. The silicon device features alignment structures that enable a passive alignment of fibers to integrated waveguides. For passive alignment, precisely machined V-grooves on a silicon device are used and the planar lightwave circuit board features high-precision structures acting as a mechanical stop. The approach has been tested for up to eight fiber-to-waveguide connections. The alignment approach, the design, and the fabrication of the silicon device as well as the assembly process are presented. The characterization of the fiber-to-waveguide link reveals total coupling losses of (0.45±0.20 dB) per coupling interface, which is significantly lower than the values reported in earlier works. Subsequent climate tests reveal that the coupling losses remain stable during thermal cycling but increases significantly during an 85°C/85 Rh-test. All applied fabrication and bonding steps have been performed using standard MOEMS fabrication and packaging processes.

Modeling of Beams’ Multiple-Contact Mode with an Application in the Design of a High-g Threshold Microaccelerometer

PubMed Central

Li, Kai; Chen, Wenyuan; Zhang, Weiping

2011-01-01

Beam’s multiple-contact mode, characterized by multiple and discrete contact regions, non-uniform stoppers’ heights, irregular contact sequence, seesaw-like effect, indirect interaction between different stoppers, and complex coupling relationship between loads and deformation is studied. A novel analysis method and a novel high speed calculation model are developed for multiple-contact mode under mechanical load and electrostatic load, without limitations on stopper height and distribution, providing the beam has stepped or curved shape. Accurate values of deflection, contact load, contact region and so on are obtained directly, with a subsequent validation by CoventorWare. A new concept design of high-g threshold microaccelerometer based on multiple-contact mode is presented, featuring multiple acceleration thresholds of one sensitive component and consequently small sensor size. PMID:22163897

G-band harmonic multiplying gyrotron traveling-wave amplifier with a mode-selective circuit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yeh, Y. S.; Chen, Chang-Hong; Wang, Z. W.

Harmonic multiplying gyrotron traveling-wave amplifiers (gyro-TWAs) permit for magnetic field reduction and frequency multiplication. A high-order-mode harmonic multiplying gyro-TWA with large circuit dimensions and low ohmic loss can achieve a high average power. By amplifying a fundamental harmonic TE{sub 01} drive wave, the second harmonic component of the beam current initiates a TE{sub 02} wave to be amplified. Wall losses can suppress some competing modes because they act as an effective sink of the energy of the modes. However, such wall losses do not suppress all competing modes as the fields are contracted in the copper section in the gyro-TWA.more » An improved mode-selective circuit, using circular waveguides with the specified radii, can provide the rejection points within the frequency range to suppress the competing modes. The simulated results reveal that the mode-selective circuit can provide an attenuation of more than 10 dB to suppress the competing modes (TE{sub 21}, TE{sub 51}, TE{sub 22}, and TE{sub 03}). A G-band second harmonic multiplying gyro-TWA with the mode-selective circuit is predicted to yield a peak output power of 50 kW at 198.8 GHz, corresponding to a saturated gain of 55 dB at an interaction efficiency of 10%. The full width at half maximum bandwidth is 5 GHz.« less

Effects of Swept Tips on V-22 Whirl Flutter and Loads

NASA Technical Reports Server (NTRS)

Acree, C. W., Jr.

2005-01-01

A CAMRAD II model of the V-22 Osprey tiltrotor was constructed for the purpose of analyzing the effects of blade design changes on whirl flutter. The model incorporated a dual load-path grip/yoke assembly, a swashplate coupled to the transmission case, and a drive train. A multiple-trailer free wake was used for loads calculations. The effects of rotor design changes on whirl-mode stability were calculated for swept blades and offset tip masses. A rotor with swept tips and inboard tuning masses was examined in detail to reveal the mechanisms by which these design changes affect stability and loads. Certain combinations of design features greatly increased whirl-mode stability, with (at worst) moderate increases to loads.

Mode Behavior in Ultralarge Ring Lasers

NASA Astrophysics Data System (ADS)

Hurst, Robert B.; Dunn, Robert W.; Schreiber, K. Ulrich; Thirkettle, Robert J.; MacDonald, Graeme K.

2004-04-01

Contrary to expectations based on mode spacing, single-mode operation in very large He-Ne ring lasers may be achieved at intracavity power levels up to ~0.15 times the saturation intensity for the He-Ne transition. Homogeneous line broadening at a high total gas pressure of 4-6 Torr allows a single-peaked gain profile that suppresses closely spaced multiple modes. At startup, decay of initial multiple modes may take tens of seconds. The single remaining mode in each direction persists metastably as the cavity is detuned by many times the mode frequency spacing. A theoretical explanation requires the gain profile to be concave down and to satisfy an inequality related to slope and saturation at the operating frequency. Calculated metastable frequency ranges are greater than 150 MHz at 6 Torr and depend strongly on pressure. Examples of unusual stable mode configurations are shown, with differently numbered modes in the two directions and with multiple modes at a spacing of ~100 MHz.

Mode behavior in ultralarge ring lasers.

PubMed

Hurst, Robert B; Dunn, Robert W; Schreiber, K Ulrich; Thirkettle, Robert J; MacDonald, Graeme K

2004-04-10

Contrary to expectations based on mode spacing, single-mode operation in very large He-Ne ring lasers may be achieved at intracavity power levels up to approximately0.15 times the saturation intensity for the He-Ne transition. Homogeneous line broadening at a high total gas pressure of 4-6 Torr allows a single-peaked gain profile that suppresses closely spaced multiple modes. At startup, decay of initial multiple modes may take tens of seconds. The single remaining mode in each direction persists metastably as the cavity is detuned by many times the mode frequency spacing. A theoretical explanation requires the gain profile to be concave down and to satisfy an inequality related to slope and saturation at the operating frequency. Calculated metastable frequency ranges are > 150 MHz at 6 Torr and depend strongly on pressure. Examples of unusual stable mode configurations are shown, with differently numbered modes in the two directions and with multiple modes at a spacing of approximately 100 MHz.

Deep Chandra , HST-COS, and megacam observations of the Phoenix cluster: Extreme star formation and AGN feedback on hundred kiloparsec scales

DOE PAGES

McDonald, Michael; McNamara, Brian R.; Perimeter Institute for Theoretical Physics, Waterloo; ...

2015-09-28

In this study, we present new ultraviolet, optical, and X-ray data on the Phoenix galaxy cluster (SPT-CLJ2344-4243). Deep optical imaging reveals previously undetected filaments of star formation, extending to radii of ~50–100 kpc in multiple directions. Combined UV-optical spectroscopy of the central galaxy reveals a massive (2 × 10 9 M ⊙), young (~4.5 Myr) population of stars, consistent with a time-averaged star formation rate of 610 ± 50 M ⊙ yr –1. We report a strong detection of O vi λλ1032,1038, which appears to originate primarily in shock-heated gas, but may contain a substantial contribution (>1000 M ⊙ yrmore » –1) from the cooling intracluster medium (ICM). We confirm the presence of deep X-ray cavities in the inner ~10 kpc, which are among the most extreme examples of radio-mode feedback detected to date, implying jet powers of 2 – 7 × 10 45 erg s –1. We provide evidence that the active galactic nucleus inflating these cavities may have only recently transitioned from "quasar-mode" to "radio-mode," and may currently be insufficient to completely offset cooling. A model-subtracted residual X-ray image reveals evidence for prior episodes of strong radio-mode feedback at radii of ~100 kpc, with extended "ghost" cavities indicating a prior epoch of feedback roughly 100 Myr ago. This residual image also exhibits significant asymmetry in the inner ~200 kpc (0.15R 500), reminiscent of infalling cool clouds, either due to minor mergers or fragmentation of the cooling ICM. Taken together, these data reveal a rapidly evolving cool core which is rich with structure (both spatially and in temperature), is subject to a variety of highly energetic processes, and yet is cooling rapidly and forming stars along thin, narrow filaments.« less

Temperature dependent of IVR investigated by steady-state and time-frequency resolved CARS for liquid nitrobenzene and nitromethane

NASA Astrophysics Data System (ADS)

Yang, Yanqiang; Zhu, Gangbei; Yan, Lin; Liu, Xiaosong; Yang's Ultrafast Spectroscopy Group Team

2017-06-01

Intramolecular vibrational energy redistribution (IVR) is important process in thermal decomposition, shock chemistry and photochemistry. Anti-Stokes Raman scattering is sensitive to the vibrational population in excited states because only vibrational excited states are responsible to the anti-Stokes Raman scattering, does not vibrational ground states. In this report, steady-state anti-Stokes Raman spectroscopy and broad band ultrafast coherent anti-Stokes Raman scattering (CARS) are performed. The steady-state anti-Stokes Raman spectroscopy shows temperature dependent of vibrational energy redistribution in vibrational excited-state molecule, and reveal that, in liquid nitrobenzene, with temperature increasing, vibrational energy is mainly redistributed in NO2 symmetric stretching mode, and phenyl ring stretching mode of νCC. For liquid nitromethane, it is found that, with temperature increasing, vibrational energy concentrate in CN stretching mode and methyl umbrella vibrational mode. In the broad band ultrafast CARS experiment, multiple vibrational modes are coherently excited to vibrational excited states, and the time-frequency resolved CARS spectra show the coincident IVR processes. This work is supported by the National Natural Science Foundation of China (Grant Numbers 21673211 and 11372053), and the Science Challenging Program (Grant Number JCKY2016212A501).

Burst mode pumping: A new mechanism of drinking in mosquitoes

DOE PAGES

Kikuchi, Kenji; Stremler, Mark A.; Chatterjee, Souvick; ...

2018-03-20

Mosquitoes transport liquid foods into the body using two muscular pumps in the head. In normal drinking, these pumps reciprocate in a stereotyped pattern of oscillation, with a high frequency but small stroke volume. Do mosquitoes modulate their neuromotor programs for pumping to produce different drinking modes? More broadly, what are the mechanical consequences of a two-pump system in insects? To address these questions, we used synchrotron x-ray imaging and fluid mechanical modeling to investigate drinking performance in mosquitoes. X-ray imaging of the pumps during drinking revealed two modes of pumping: continuous reciprocation with multiple small strokes, and a newlymore » discovered ‘burst mode’ involving a single, large-volume stroke. Results from modeling demonstrate that burst mode pumping creates a very large pressure drop and high volume flow rate, but requires a massive increase in power, suggesting that continuous pumping is more economical for drinking. Modeling also demonstrates that, from one mode of pumping to the other, the mechanical role of the individual pumps changes. Furthermore, these results suggest that the advantage of a two-pump system in insects lies in its flexibility, enabling the animal to pump efficiently or powerfully as demanded by environmental considerations.« less

Burst mode pumping: A new mechanism of drinking in mosquitoes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kikuchi, Kenji; Stremler, Mark A.; Chatterjee, Souvick

Mosquitoes transport liquid foods into the body using two muscular pumps in the head. In normal drinking, these pumps reciprocate in a stereotyped pattern of oscillation, with a high frequency but small stroke volume. Do mosquitoes modulate their neuromotor programs for pumping to produce different drinking modes? More broadly, what are the mechanical consequences of a two-pump system in insects? To address these questions, we used synchrotron x-ray imaging and fluid mechanical modeling to investigate drinking performance in mosquitoes. X-ray imaging of the pumps during drinking revealed two modes of pumping: continuous reciprocation with multiple small strokes, and a newlymore » discovered ‘burst mode’ involving a single, large-volume stroke. Results from modeling demonstrate that burst mode pumping creates a very large pressure drop and high volume flow rate, but requires a massive increase in power, suggesting that continuous pumping is more economical for drinking. Modeling also demonstrates that, from one mode of pumping to the other, the mechanical role of the individual pumps changes. Furthermore, these results suggest that the advantage of a two-pump system in insects lies in its flexibility, enabling the animal to pump efficiently or powerfully as demanded by environmental considerations.« less

Nanoscale Spatiotemporal Diffusion Modes Measured by Simultaneous Confocal and Stimulated Emission Depletion Nanoscopy Imaging.

PubMed

Schneider, Falk; Waithe, Dominic; Galiani, Silvia; Bernardino de la Serna, Jorge; Sezgin, Erdinc; Eggeling, Christian

2018-06-19

The diffusion dynamics in the cellular plasma membrane provide crucial insights into molecular interactions, organization, and bioactivity. Beam-scanning fluorescence correlation spectroscopy combined with super-resolution stimulated emission depletion nanoscopy (scanning STED-FCS) measures such dynamics with high spatial and temporal resolution. It reveals nanoscale diffusion characteristics by measuring the molecular diffusion in conventional confocal mode and super-resolved STED mode sequentially for each pixel along the scanned line. However, to directly link the spatial and the temporal information, a method that simultaneously measures the diffusion in confocal and STED modes is needed. Here, to overcome this problem, we establish an advanced STED-FCS measurement method, line interleaved excitation scanning STED-FCS (LIESS-FCS), that discloses the molecular diffusion modes at different spatial positions with a single measurement. It relies on fast beam-scanning along a line with alternating laser illumination that yields, for each pixel, the apparent diffusion coefficients for two different observation spot sizes (conventional confocal and super-resolved STED). We demonstrate the potential of the LIESS-FCS approach with simulations and experiments on lipid diffusion in model and live cell plasma membranes. We also apply LIESS-FCS to investigate the spatiotemporal organization of glycosylphosphatidylinositol-anchored proteins in the plasma membrane of live cells, which, interestingly, show multiple diffusion modes at different spatial positions.

Low-voltage harmonic multiplying gyrotron traveling-wave amplifier in G band

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yeh, Y. S.; Guo, Y. W.; Kao, B. H.

Harmonic multiplying operation in a gyrotron traveling-wave amplifier (gyro-TWA) permits for magnetic field reduction and frequency multiplication. Lowering a beam voltage is an important step toward miniaturization of a harmonic multiplying gyro-TWA. However, the additional degree of freedom that is provided by the multitude cyclotron harmonics in a low-voltage harmonic multiplying gyro-TWA still easily generates various competing modes. An improved mode-selective circuit, using circular waveguides with various radii, can provide the rejection points within the frequency range to suppress competing modes. Simulated results reveal that the mode-selective circuit can provide an attenuation of more than 14 dB to suppress the competingmore » modes. Furthermore, the performance of the gyro-TWA is analyzed for studying the sensitivity of the saturated output power and full width at half maximum bandwidth of the gyro-TWA to the beam voltage and the magnetic field. A stable low-voltage harmonic multiplying gyro-TWA with the mode-selective circuit is predicted to yield a peak output power of 24 kW at 200.4 GHz, corresponding to a saturated gain of 56 dB at an interaction efficiency of 20%. The full width at half maximum bandwidth is 3.0 GHz.« less

Multiple switching modes and multiple level states in memristive devices

NASA Astrophysics Data System (ADS)

Miao, Feng; Yang, J. Joshua; Borghetti, Julien; Strachan, John Paul; Zhang, M.-X.; Goldfarb, Ilan; Medeiros-Ribeiro, Gilberto; Williams, R. Stanley

2011-03-01

As one of the most promising technologies for next generation non-volatile memory, metal oxide based memristive devices have demonstrated great advantages on scalability, operating speed and power consumption. Here we report the observation of multiple switching modes and multiple level states in different memristive systems. The multiple switching modes can be obtained by limiting the current during electroforming, and related transport behaviors, including ionic and electronic motions, are characterized. Such observation can be rationalized by a model of two effective switching layers adjacent to the bottom and top electrodes. Multiple level states, corresponding to different composition of the conducting channel, will also be discussed in the context of multiple-level storage for high density, non-volatile memory applications.

Infrared Laser Spectroscopy of the n-PROPYL and i-PROPYL Radicals in Helium Droplets: Significant Bend-Stretch Coupling Revealed in the CH Stretch Region

NASA Astrophysics Data System (ADS)

Moradi, Christopher P.; Douberly, Gary E.; Tabor, Daniel P.; Sibert, Edwin

2016-06-01

The n-propyl and i-propyl radicals were generated in the gas phase via pyrolysis of n-butyl nitrite (CH3(CH2)3ONO) and i-butyl nitrite (CH3CH(CH3)CH2ONO) precursors, respectively. Nascent radicals were promptly solvated by a beam of He nanodroplets, and the infrared spectra of the radicals were recorded in the C-H stretching region. In addition to three vibrations of n-propyl previously measured in an Ar matrix, we observe many unreported bands between 2800 and 3150 wn, which we attribute to propyl radicals. The C-H stretching modes observed above 2960 wn for both radicals are in excellent agreement with anharmonic frequencies computed using VPT2. Between 2800 and 2960 wn, however, the spectra of n-propyl and i-propyl radicals become quite congested and difficult to assign due to the presence of multiple anharmonic resonances. Computations employing a local mode Hamiltonian reveal the origin of the spectral congestion to be strong coupling between the high frequency C-H stretching modes and the lower frequency bending/scissoring motions. The only significant local coupling is between stretches and bends on the same CH2/CH3 group.

An Orbital Angular Momentum (OAM) Mode Reconfigurable Antenna for Channel Capacity Improvement and Digital Data Encoding.

PubMed

Liu, Baiyang; Lin, Guoying; Cui, Yuehui; Li, RongLin

2017-08-29

For purpose of utilizing orbital angular momentum (OAM) mode diversity, multiple OAM beams should be generated preferably by a single antenna. In this paper, an OAM mode reconfigurable antenna is proposed. Different from the existed OAM antennas with multiple ports for multiple OAM modes transmitting, the proposed antenna with only a single port, but it can be used to transmit mode 1 or mode -1 OAM beams arbitrary by controlling the PIN diodes on the feeding network through a programmable microcontroller which control by a remote controller. Simulation and measurement results such as return loss, near-field and far-field radiation patterns of two operating states for mode 1 and mode -1, and OAM mode orthogonality are given. The proposed antenna can serve as a candidate for utilizing OAM diversity, namely phase diversity to increase channel capacity at 2.4 GHz. Moreover, an OAM-mode based encoding method is experimentally carried out by the proposed OAM mode reconfigurable antenna, the digital data are encoded and decoded by different OAM modes. At the transmitter, the proposed OAM mode reconfigurable antenna is used to encode the digital data, data symbol 0 and 1 are mapped to OAM mode 1 and mode -1, respectively. At the receiver, the data symbols are decoded by phase gradient method.

Simultaneous excitation of extremely high-Q-factor trapped and octupolar modes in terahertz metamaterials.

PubMed

Yang, Shengyan; Tang, Chengchun; Liu, Zhe; Wang, Bo; Wang, Chun; Li, Junjie; Wang, Li; Gu, Changzhi

2017-07-10

Achieving high-Q-factor resonances allows dramatic enhancement of performance of many plasmonic devices. However, the excitation of high-Q-factor resonance, especially multiple high-Q-factor resonances, has been a big challenge in traditional metamaterials due to the ohmic and radiation losses. Here, we experimentally demonstrate simultaneous excitation of double extremely sharp resonances in a terahertz metamaterial composed of mirror-symmetric-broken double split ring resonators (MBDSRRs). In a regular mirror-arranged SRR array, only the low-Q-factor dipole resonance can be excited with the external electric field perpendicular to the SRR gap. Breaking the mirror-symmetry of the metamaterial leads to the occurrence of two distinct otherwise inaccessible ultrahigh-Q-factor modes, which consists of one trapped mode in addition to an octupolar mode. By tuning the asymmetry parameter, the Q factor of the trapped mode can be linearly modulated, while the Q factor of the octupolar mode can be tailored exponentially. For specific degree of asymmetry, our simulations revealed a significantly high Q factor (Q>100) for the octupolar mode, which is more than one order of magnitude larger than that of conventional metamaterials. The mirror-symmetry-broken metamaterial offers the advantage of enabling access to two distinct high-Q-factor resonances which could be exploited for ultrasensitive sensors, multiband filters, and slow light devices.

Study of Wave-Particle Interactions for Whistler Mode Waves at Oblique Angles by Utilizing the Gyroaveraging Method

NASA Astrophysics Data System (ADS)

Hsieh, Yi-Kai; Omura, Yoshiharu

2017-10-01

We investigate the properties of whistler mode wave-particle interactions at oblique wave normal angles to the background magnetic field. We find that electromagnetic energy of waves at frequencies below half the electron cyclotron frequency can flow nearly parallel to the ambient magnetic field. We thereby confirm that the gyroaveraging method, which averages the cyclotron motion to the gyrocenter and reduces the simulation from two-dimensional to one-dimensional, is valid for oblique wave-particle interaction. Multiple resonances appear for oblique propagation but not for parallel propagation. We calculate the possible range of resonances with the first-order resonance condition as a function of electron kinetic energy and equatorial pitch angle. To reveal the physical process and the efficiency of electron acceleration by multiple resonances, we assume a simple uniform wave model with constant amplitude and frequency in space and time. We perform test particle simulations with electrons starting at specific equatorial pitch angles and kinetic energies. The simulation results show that multiple resonances contribute to acceleration and pitch angle scattering of energetic electrons. Especially, we find that electrons with energies of a few hundred keV can be accelerated efficiently to a few MeV through the n = 0 Landau resonance.

Dynamics and allostery of the ionotropic glutamate receptors and the ligand binding domain.

PubMed

Tobi, Dror

2016-02-01

The dynamics of the ligand-binding domain (LBD) and the intact ionotropic glutamate receptor (iGluR) were studied using Gaussian Network Model (GNM) analysis. The dynamics of LBDs with various allosteric modulators is compared using a novel method of multiple alignment of GNM modes of motion. The analysis reveals that allosteric effectors change the dynamics of amino acids at the upper lobe interface of the LBD dimer as well as at the hinge region between the upper- and lower- lobes. For the intact glutamate receptor the analysis show that the clamshell-like movement of the LBD upper and lower lobes is coupled to the bending of the trans-membrane domain (TMD) helices which may open the channel pore. The results offer a new insight on the mechanism of action of allosteric modulators on the iGluR and support the notion of TMD helices bending as a possible mechanism for channel opening. In addition, the study validates the methodology of multiple GNM modes alignment as a useful tool to study allosteric effect and its relation to proteins dynamics. © 2015 Wiley Periodicals, Inc.

Multi-scale pixel-based image fusion using multivariate empirical mode decomposition.

PubMed

Rehman, Naveed ur; Ehsan, Shoaib; Abdullah, Syed Muhammad Umer; Akhtar, Muhammad Jehanzaib; Mandic, Danilo P; McDonald-Maier, Klaus D

2015-05-08

A novel scheme to perform the fusion of multiple images using the multivariate empirical mode decomposition (MEMD) algorithm is proposed. Standard multi-scale fusion techniques make a priori assumptions regarding input data, whereas standard univariate empirical mode decomposition (EMD)-based fusion techniques suffer from inherent mode mixing and mode misalignment issues, characterized respectively by either a single intrinsic mode function (IMF) containing multiple scales or the same indexed IMFs corresponding to multiple input images carrying different frequency information. We show that MEMD overcomes these problems by being fully data adaptive and by aligning common frequency scales from multiple channels, thus enabling their comparison at a pixel level and subsequent fusion at multiple data scales. We then demonstrate the potential of the proposed scheme on a large dataset of real-world multi-exposure and multi-focus images and compare the results against those obtained from standard fusion algorithms, including the principal component analysis (PCA), discrete wavelet transform (DWT) and non-subsampled contourlet transform (NCT). A variety of image fusion quality measures are employed for the objective evaluation of the proposed method. We also report the results of a hypothesis testing approach on our large image dataset to identify statistically-significant performance differences.

Multi-Scale Pixel-Based Image Fusion Using Multivariate Empirical Mode Decomposition

PubMed Central

Rehman, Naveed ur; Ehsan, Shoaib; Abdullah, Syed Muhammad Umer; Akhtar, Muhammad Jehanzaib; Mandic, Danilo P.; McDonald-Maier, Klaus D.

2015-01-01

A novel scheme to perform the fusion of multiple images using the multivariate empirical mode decomposition (MEMD) algorithm is proposed. Standard multi-scale fusion techniques make a priori assumptions regarding input data, whereas standard univariate empirical mode decomposition (EMD)-based fusion techniques suffer from inherent mode mixing and mode misalignment issues, characterized respectively by either a single intrinsic mode function (IMF) containing multiple scales or the same indexed IMFs corresponding to multiple input images carrying different frequency information. We show that MEMD overcomes these problems by being fully data adaptive and by aligning common frequency scales from multiple channels, thus enabling their comparison at a pixel level and subsequent fusion at multiple data scales. We then demonstrate the potential of the proposed scheme on a large dataset of real-world multi-exposure and multi-focus images and compare the results against those obtained from standard fusion algorithms, including the principal component analysis (PCA), discrete wavelet transform (DWT) and non-subsampled contourlet transform (NCT). A variety of image fusion quality measures are employed for the objective evaluation of the proposed method. We also report the results of a hypothesis testing approach on our large image dataset to identify statistically-significant performance differences. PMID:26007714

Raman studies of single-walled carbon nanotubes synthesized by pulsed laser ablation at room temperature

NASA Astrophysics Data System (ADS)

Dixit, Saurabh; Shukla, A. K.

2018-06-01

In this article, single-walled carbon nanotubes (SWCNTs) are synthesized at room temperature using pulsed laser ablation of ferrocene mixed graphitic target. Radial breathing mode (RBM) reveals the presence of semiconducting SWCNTs of multiple diameters. Quantum confinement model is developed for Raman line-shape of G - feature. It is invoked here that G-feature is the manifestation of TO phonons in the semiconducting SWCNTs. Disorder in the SWCNTs is studied here as a function of the concentration of ferrocene in the graphitic target using X-ray diffraction analysis, oscillator strength of G - feature and D mode and Raman line-shape model of G - feature. Furthermore, phonon softening of G - feature of semiconducting SWCNTs is observed as a function of the diameter of nanotube.

Molecular Imaging of Ultrathin Pentacene Films: Evidence for Homoepitaxy

NASA Astrophysics Data System (ADS)

Wu, Yanfei; Haugstad, Greg; Frisbie, C. Daniel

2013-03-01

Ultrathin polycrystalline films of organic semiconductors have received intensive investigations due to the critical role they play in governing the performance of organic thin film transistors. In this work, a variety of scanning probe microscopy (SPM) techniques have been employed to investigate ultrathin polycrystalline films (1-3 nm) of the benchmark organic semiconductor pentacene. By using spatially resolved Friction Force Microscopy (FFM), Kelvin Probe Force Microscopy (KFM) and Electrostatic Force Microscopy (EFM), an interesting multi-domain structure is revealed within the second layer of the films, characterized as two distinct friction and surface potential domains correlating with each other. The existence of multiple homoepitaxial modes within the films is thus proposed and examined. By employing lattice-revolved imaging using contact mode SPM, direct molecular evidence for the unusual homoepitaxy is obtained.

Probing protein flexibility reveals a mechanism for selective promiscuity

PubMed Central

Pabon, Nicolas A; Camacho, Carlos J

2017-01-01

Many eukaryotic regulatory proteins adopt distinct bound and unbound conformations, and use this structural flexibility to bind specifically to multiple partners. However, we lack an understanding of how an interface can select some ligands, but not others. Here, we present a molecular dynamics approach to identify and quantitatively evaluate the interactions responsible for this selective promiscuity. We apply this approach to the anticancer target PD-1 and its ligands PD-L1 and PD-L2. We discover that while unbound PD-1 exhibits a hard-to-drug hydrophilic interface, conserved specific triggers encoded in the cognate ligands activate a promiscuous binding pathway that reveals a flexible hydrophobic binding cavity. Specificity is then established by additional contacts that stabilize the PD-1 cavity into distinct bound-like modes. Collectively, our studies provide insight into the structural basis and evolution of multiple binding partners, and also suggest a biophysical approach to exploit innate binding pathways to drug seemingly undruggable targets. DOI: http://dx.doi.org/10.7554/eLife.22889.001 PMID:28432789

Temporal genetic structure in a poecilogonous polychaete: the interplay of developmental mode and environmental stochasticity

PubMed Central

2014-01-01

Background Temporal variation in the genetic structure of populations can be caused by multiple factors, including natural selection, stochastic environmental variation, migration, or genetic drift. In benthic marine species, the developmental mode of larvae may indicate a possibility for temporal genetic variation: species with dispersive planktonic larvae are expected to be more likely to show temporal genetic variation than species with benthic or brooded non-dispersive larvae, due to differences in larval mortality and dispersal ability. We examined temporal genetic structure in populations of Pygospio elegans, a poecilogonous polychaete with within-species variation in developmental mode. P. elegans produces either planktonic, benthic, or intermediate larvae, varying both among and within populations, providing a within-species test of the generality of a relationship between temporal genetic variation and larval developmental mode. Results In contrast to our expectations, our microsatellite analyses of P. elegans revealed temporal genetic stability in the UK population with planktonic larvae, whereas there was variation indicative of drift in temporal samples of the populations from the Baltic Sea, which have predominantly benthic and intermediate larvae. We also detected temporal variation in relatedness within these populations. A large temporal shift in genetic structure was detected in a population from the Netherlands, having multiple developmental modes. This shift could have been caused by local extiction due to extreme environmental conditions and (re)colonization by planktonic larvae from neighboring populations. Conclusions In our study of P. elegans, temporal genetic variation appears to be due to not only larval developmental mode, but also the stochastic environment of adults. Large temporal genetic shifts may be more likely in marine intertidal habitats (e.g. North Sea and Wadden Sea) which are more prone to environmental stochasticity than the sub-tidal Baltic habitats. Sub-tidal and/or brackish (less saline) habitats may support smaller P. elegans populations and these may be more susceptible to the effects of random genetic drift. Moreover, higher frequencies of asexual reproduction and the benthic larval developmental mode in these populations leads to higher relatedness and contributes to drift. Our results indicate that a general relationship between larval developmental mode and temporal genetic variation may not exist. PMID:24447386

Temporal genetic structure in a poecilogonous polychaete: the interplay of developmental mode and environmental stochasticity.

PubMed

Kesäniemi, Jenni E; Mustonen, Marina; Boström, Christoffer; Hansen, Benni W; Knott, K Emily

2014-01-22

Temporal variation in the genetic structure of populations can be caused by multiple factors, including natural selection, stochastic environmental variation, migration, or genetic drift. In benthic marine species, the developmental mode of larvae may indicate a possibility for temporal genetic variation: species with dispersive planktonic larvae are expected to be more likely to show temporal genetic variation than species with benthic or brooded non-dispersive larvae, due to differences in larval mortality and dispersal ability. We examined temporal genetic structure in populations of Pygospio elegans, a poecilogonous polychaete with within-species variation in developmental mode. P. elegans produces either planktonic, benthic, or intermediate larvae, varying both among and within populations, providing a within-species test of the generality of a relationship between temporal genetic variation and larval developmental mode. In contrast to our expectations, our microsatellite analyses of P. elegans revealed temporal genetic stability in the UK population with planktonic larvae, whereas there was variation indicative of drift in temporal samples of the populations from the Baltic Sea, which have predominantly benthic and intermediate larvae. We also detected temporal variation in relatedness within these populations. A large temporal shift in genetic structure was detected in a population from the Netherlands, having multiple developmental modes. This shift could have been caused by local extiction due to extreme environmental conditions and (re)colonization by planktonic larvae from neighboring populations. In our study of P. elegans, temporal genetic variation appears to be due to not only larval developmental mode, but also the stochastic environment of adults. Large temporal genetic shifts may be more likely in marine intertidal habitats (e.g. North Sea and Wadden Sea) which are more prone to environmental stochasticity than the sub-tidal Baltic habitats. Sub-tidal and/or brackish (less saline) habitats may support smaller P. elegans populations and these may be more susceptible to the effects of random genetic drift. Moreover, higher frequencies of asexual reproduction and the benthic larval developmental mode in these populations leads to higher relatedness and contributes to drift. Our results indicate that a general relationship between larval developmental mode and temporal genetic variation may not exist.

CMOS imager for pointing and tracking applications

NASA Technical Reports Server (NTRS)

Sun, Chao (Inventor); Pain, Bedabrata (Inventor); Yang, Guang (Inventor); Heynssens, Julie B. (Inventor)

2006-01-01

Systems and techniques to realize pointing and tracking applications with CMOS imaging devices. In general, in one implementation, the technique includes: sampling multiple rows and multiple columns of an active pixel sensor array into a memory array (e.g., an on-chip memory array), and reading out the multiple rows and multiple columns sampled in the memory array to provide image data with reduced motion artifact. Various operation modes may be provided, including TDS, CDS, CQS, a tracking mode to read out multiple windows, and/or a mode employing a sample-first-read-later readout scheme. The tracking mode can take advantage of a diagonal switch array. The diagonal switch array, the active pixel sensor array and the memory array can be integrated onto a single imager chip with a controller. This imager device can be part of a larger imaging system for both space-based applications and terrestrial applications.

Linearly polarized vector modes: enabling MIMO-free mode-division multiplexing.

PubMed

Wang, Lixian; Nejad, Reza Mirzaei; Corsi, Alessandro; Lin, Jiachuan; Messaddeq, Younès; Rusch, Leslie; LaRochelle, Sophie

2017-05-15

We experimentally investigate mode-division multiplexing in an elliptical ring core fiber (ERCF) that supports linearly polarized vector modes (LPV). Characterization show that the ERCF exhibits good polarization maintaining properties over eight LPV modes with effective index difference larger than 1 × 10 -4 . The ERCF further displays stable mode power and polarization extinction ratio when subjected to external perturbations. Crosstalk between the LPV modes, after propagating through 0.9 km ERCF, is below -14 dB. By using six LPV modes as independent data channels, we achieved the transmission of 32 Gbaud QPSK over 0.9 km ERCF without any multiple-input-multiple-output (MIMO) or polarization-division multiplexing (PDM) signal processing.

Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells

PubMed Central

Cao, Lulu; Ding, Yiyuan; Hung, Norris; Yu, Kebing; Ritz, Anna; Raphael, Benjamin J.; Salomon, Arthur R.

2012-01-01

The SH2-domain-containing leukocyte protein of 76 kDa (SLP-76) plays a critical scaffolding role in T cell receptor (TCR) signaling. As an adaptor protein that contains multiple protein-binding domains, SLP-76 interacts with many signaling molecules and links proximal receptor stimulation to downstream effectors. The function of SLP-76 in TCR signaling has been widely studied using the Jurkat human leukaemic T cell line through protein disruption or site-directed mutagenesis. However, a wide-scale characterization of SLP-76-dependant phosphorylation events is still lacking. Quantitative profiling of over a hundred tyrosine phosphorylation sites revealed new modes of regulation of phosphorylation of PAG, PI3K, and WASP while reconfirming previously established regulation of Itk, PLCγ, and Erk phosphorylation by SLP-76. The absence of SLP-76 also perturbed the phosphorylation of Src family kinases (SFKs) Lck and Fyn, and subsequently a large number of SFK-regulated signaling molecules. Altogether our data suggests unique modes of regulation of positive and negative feedback pathways in T cells by SLP-76, reconfirming its central role in the pathway. PMID:23071622

Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells.

PubMed

Cao, Lulu; Ding, Yiyuan; Hung, Norris; Yu, Kebing; Ritz, Anna; Raphael, Benjamin J; Salomon, Arthur R

2012-01-01

The SH2-domain-containing leukocyte protein of 76 kDa (SLP-76) plays a critical scaffolding role in T cell receptor (TCR) signaling. As an adaptor protein that contains multiple protein-binding domains, SLP-76 interacts with many signaling molecules and links proximal receptor stimulation to downstream effectors. The function of SLP-76 in TCR signaling has been widely studied using the Jurkat human leukaemic T cell line through protein disruption or site-directed mutagenesis. However, a wide-scale characterization of SLP-76-dependant phosphorylation events is still lacking. Quantitative profiling of over a hundred tyrosine phosphorylation sites revealed new modes of regulation of phosphorylation of PAG, PI3K, and WASP while reconfirming previously established regulation of Itk, PLCγ, and Erk phosphorylation by SLP-76. The absence of SLP-76 also perturbed the phosphorylation of Src family kinases (SFKs) Lck and Fyn, and subsequently a large number of SFK-regulated signaling molecules. Altogether our data suggests unique modes of regulation of positive and negative feedback pathways in T cells by SLP-76, reconfirming its central role in the pathway.

Photonic band gap properties of one-dimensional Thue-Morse all-dielectric photonic quasicrystal

NASA Astrophysics Data System (ADS)

Yue, Chenxi; Tan, Wei; Liu, Jianjun

2018-05-01

In this paper, the photonic band gap (PBG) properties of one-dimensional (1D) Thue-Morse photonic quasicrystal (PQC) S4 structure are theoretically investigated by using transfer matrix method in Bragg condition. The effects of the center wavelength, relative permittivity and incident angle on PBG properties are elaborately analyzed. Numerical results reveal that, in the case of normal incidence, the symmetry and periodicity properties of the photonic band structure are presented. As the center wavelength increases, the PBG center frequency and PBG width decrease while the photonic band structure is always symmetrical about the central frequency and the photonic band structure repeats periodically in the expanding observation frequency range. With the decrease of relative permittivity contrast, the PBG width and the relative PBG width gradually decreases until PBG disappears while the symmetry of the photonic band structure always exists. In the case of oblique incidence, as the incident angle increases, multiple narrow PBGs gradually merge into a wide PBG for the TE mode while for the TM mode, the number of PBG continuously decreases and eventually disappears, i.e., multiple narrow PBGs become a wide passband for the TM mode. The research results will provide a reference for the choice of the material, the incident angle for the PBG properties and its applications of 1D Thue-Morse PQC.

CW EPR parameters reveal cytochrome P450 ligand binding modes.

PubMed

Lockart, Molly M; Rodriguez, Carlo A; Atkins, William M; Bowman, Michael K

2018-06-01

Cytochrome P450 (CYP) monoxygenses utilize heme cofactors to catalyze oxidation reactions. They play a critical role in metabolism of many classes of drugs, are an attractive target for drug development, and mediate several prominent drug interactions. Many substrates and inhibitors alter the spin state of the ferric heme by displacing the heme's axial water ligand in the resting enzyme to yield a five-coordinate iron complex, or they replace the axial water to yield a nitrogen-ligated six-coordinate iron complex, which are traditionally assigned by UV-vis spectroscopy. However, crystal structures and recent pulsed electron paramagnetic resonance (EPR) studies find a few cases where molecules hydrogen bond to the axial water. The water-bridged drug-H 2 O-heme has UV-vis spectra similar to nitrogen-ligated, six-coordinate complexes, but are closer to "reverse type I" complexes described in older liteature. Here, pulsed and continuous wave (CW) EPR demonstrate that water-bridged complexes are remarkably common among a range of nitrogenous drugs or drug fragments that bind to CYP3A4 or CYP2C9. Principal component analysis reveals a distinct clustering of CW EPR spectral parameters for water-bridged complexes. CW EPR reveals heterogeneous mixtures of ligated states, including multiple directly-coordinated complexes and water-bridged complexes. These results suggest that water-bridged complexes are under-represented in CYP structural databases and can have energies similar to other ligation modes. The data indicates that water-bridged binding modes can be identified and distinguished from directly-coordinated binding by CW EPR. Copyright © 2018 Elsevier Inc. All rights reserved.

Tuning diagonal components of static linear and first nonlinear polarizabilities of doped quantum dots by Gaussian white noise

NASA Astrophysics Data System (ADS)

Ganguly, Jayanta; Ghosh, Manas

2015-07-01

We investigate the modulation of diagonal components of static linear (αxx, αyy) and first nonlinear (βxxx, βyyy) polarizabilities of quantum dots by Gaussian white noise. Quantum dot is doped with impurity represented by a Gaussian potential and repulsive in nature. The study reveals the importance of mode of application of noise (additive/multiplicative) on the polarizability components. The doped system is further exposed to a static external electric field of given intensity. As important observation we have found that the strength of additive noise becomes unable to influence the polarizability components. However, the multiplicative noise influences them conspicuously and gives rise to additional interesting features. Multiplicative noise even enhances the magnitude of the polarizability components immensely. The present investigation deems importance in view of the fact that noise seriously affects the optical properties of doped quantum dot devices.

Diagnosis of Cell Death by Means of Infrared Spectroscopy

PubMed Central

Zelig, Udi; Kapelushnik, Joseph; Moreh, Raymond; Mordechai, Shaul; Nathan, Ilana

2009-01-01

Abstract Fourier transform infrared (FTIR) spectroscopy has been established as a fast spectroscopic method for biochemical analysis of cells and tissues. In this research we aimed to investigate FTIR's utility for identifying and characterizing different modes of cell death, using leukemic cell lines as a model system. CCRF-CEM and U937 leukemia cells were treated with arabinoside and doxorubicin apoptosis inducers, as well as with potassium cyanide, saponin, freezing-thawing, and H2O2 necrosis inducers. Cell death mode was determined by various gold standard biochemical methods in parallel with FTIR-microscope measurements. Both cell death modes exhibit large spectral changes in lipid absorbance during apoptosis and necrosis; however, these changes are similar and thus cannot be used to distinguish apoptosis from necrosis. In contrast to the above confounding factor, our results reveal that apoptosis and necrosis can still be distinguished by the degree of DNA opaqueness to infrared light. Moreover, these two cell death modes also can be differentiated by their infrared absorbance, which relates to the secondary structure of total cellular protein. In light of these findings, we conclude that, because of its capacity to monitor multiple biomolecular parameters, FTIR spectroscopy enables unambiguous and easy analysis of cell death modes and may be useful for biochemical and medical applications. PMID:19804743

Network-based analysis of genotype-phenotype correlations between different inheritance modes.

PubMed

Hao, Dapeng; Li, Chuanxing; Zhang, Shaojun; Lu, Jianping; Jiang, Yongshuai; Wang, Shiyuan; Zhou, Meng

2014-11-15

Recent studies on human disease have revealed that aberrant interaction between proteins probably underlies a substantial number of human genetic diseases. This suggests a need to investigate disease inheritance mode using interaction, and based on which to refresh our conceptual understanding of a series of properties regarding inheritance mode of human disease. We observed a strong correlation between the number of protein interactions and the likelihood of a gene causing any dominant diseases or multiple dominant diseases, whereas no correlation was observed between protein interaction and the likelihood of a gene causing recessive diseases. We found that dominant diseases are more likely to be associated with disruption of important interactions. These suggest inheritance mode should be understood using protein interaction. We therefore reviewed the previous studies and refined an interaction model of inheritance mode, and then confirmed that this model is largely reasonable using new evidences. With these findings, we found that the inheritance mode of human genetic diseases can be predicted using protein interaction. By integrating the systems biology perspectives with the classical disease genetics paradigm, our study provides some new insights into genotype-phenotype correlations. haodapeng@ems.hrbmu.edu.cn or biofomeng@hotmail.com Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

2007 Precision Strike Annual Programs Review

DTIC Science & Technology

2007-04-25

Adapting our methods • Remaining a flexible combined-arms force • Enabling a generation of combat- experienced decision-makers by distributing...Sustain Propulsion Network RadioMEMS IMU Flexible Engagement Options Requirements Capabilities Precision Attack Missile (PAM) 67” (with Canister...Aimpoint 6 PAM Seeker Modes PAM’s Multiple Targeting Modes Increase Flexibility , Improve Lethality PAM’s Multiple Targeting Modes Increase Flexibility

Application of Spectral Analysis Techniques in the Intercomparison of Aerosol Data: 1. an EOF Approach to the Spatial-Temporal Variability of Aerosol Optical Depth Using Multiple Remote Sensing Data Sets

NASA Technical Reports Server (NTRS)

Li, Jing; Carlson, Barbara E.; Lacis, Andrew A.

2013-01-01

Many remote sensing techniques and passive sensors have been developed to measure global aerosol properties. While instantaneous comparisons between pixel-level data often reveal quantitative differences, here we use Empirical Orthogonal Function (EOF) analysis, also known as Principal Component Analysis, to demonstrate that satellite-derived aerosol optical depth (AOD) data sets exhibit essentially the same spatial and temporal variability and are thus suitable for large-scale studies. Analysis results show that the first four EOF modes of AOD account for the bulk of the variance and agree well across the four data sets used in this study (i.e., Aqua MODIS, Terra MODIS, MISR, and SeaWiFS). Only SeaWiFS data over land have slightly different EOF patterns. Globally, the first two EOF modes show annual cycles and are mainly related to Sahara dust in the northern hemisphere and biomass burning in the southern hemisphere, respectively. After removing the mean seasonal cycle from the data, major aerosol sources, including biomass burning in South America and dust in West Africa, are revealed in the dominant modes due to the different interannual variability of aerosol emissions. The enhancement of biomass burning associated with El Niño over Indonesia and central South America is also captured with the EOF technique.

On the plasmonic properties of a symmetry-breaking silver nanoring structure

NASA Astrophysics Data System (ADS)

Jiang, Bozhi; Sun, Cheng

2018-07-01

This work reports on a study regarding the plasmonic properties of a symmetry-breaking silver nanoring structure, in the wavelength range of 0.6-4.5 μm. A broken silver ring with a certain angle, as well as a full ring composed of silver and other metallic/dielectric materials, are proposed. The extinction efficiencies of the nanostructure are numerically calculated with several parameters being varied, including the broken angle, the inner and outer radii, and the thickness of the broken ring, as well as the material in the composite full ring. Multiple plasmonic resonances are observed in the extinction efficiency curves, which are attributed to the quadrupolar, octupolar, and hexadecapolar resonance modes that are revealed by the electric field distributions. The results demonstrate that the high-order modes can be altered, by varying the value of the broken angle of the ring. It is also illustrated that the resonance wavelength and the full width at half maximum of certain high-order plasmonic resonance peaks can be tuned in the wavelength range studied, by adjusting the values of the geometrical parameters of the nanoring. The plasmonic characteristics of the symmetry-breaking nanoring structure revealed in this study, provide a great platform for the designs of plasmonic devices utilizing the high-order plasmonic resonances. Besides, it is also proposed a scheme to switch the device between the multi-wavelength and single-wavelength modes.

Broadband multiple responses of surface modes in quasicrystalline plasmonic structure

PubMed Central

Yuan, Haiming; Jiang, Xiangqian; Huang, Feng; Sun, Xiudong

2016-01-01

We numerically study the multiple excitation of surface modes in 2D photonic quasicrystal/metal/substrate structure. An improved rigorous coupled wave analysis method that can handle the quasicrystalline structure is presented. The quasicrystalline lattice, which refers to Penrose tiling in this paper, is generated by the cut-and-project method. The normal incidence spectrum presents a broadband multiple responses property. We find that the phase matching condition determines the excitation frequency for a given incident angle, while the depth of the reflection valley depends on the incident polarization. The modes will split into several sub-modes at oblique incidence, which give rise to the appearance of more responses on the spectrum. PMID:27492782

An Experimental and Numerical Study of Roughness-Induced Instabilities in a Mach 3.5 Boundary Layer

NASA Technical Reports Server (NTRS)

Kegerise, Michael A.; King, Rudolph A.; Owens, Lewis R.; Choudhari, Meelan M.; Norris, Andrew T.; Li, Fei; Chang, Chau-Layn

2012-01-01

Progress on a joint experimental and numerical study of laminar-to-turbulent transition induced by an isolated roughness element in a high-speed laminar boundary layer is reported in this paper. The numerical analysis suggests that transition is driven by the instability of high- and low-speed streaks embedded in the wake of the isolated roughness element. In addition, spatial stability analysis revealed that the wake flow supports multiple modes (even and odd) of convective instabilities that experience strong enough growth to cause transition. The experimental measurements, which included hot-wire and pitot-probe surveys, confirmed the existence of embedded high- and low-speed streaks in the roughness wake. Furthermore, the measurements indicate the presence of both even and odd modes of instability, although their relative magnitude depends on the specifics of the roughness geometry and flow conditions (e.g., the value of Re(sub kk) or k/delta. For the two test cases considered in the measurements (Re(sub kk) values of 462 and 319), the even mode and the odd mode were respectively dominant and appear to play a primary role in the transition process.

Individual differences in hemispheric preference and emotion regulation difficulties

PubMed Central

Gupta, Garima; Dubey, Akanksha; Saxena, Prachi; Pandey, Rakesh

2011-01-01

Background: Hemisphericity or individual difference in the preference to use the left or the right hemispheric mode of information processing has been associated with various emotion-related differences. For example, the right hemisphericity has been linked with inhibition of emotional expression, feeling of tension, greater impulsivity etc. These observations suggest that right hemisphericity may be associated with greater difficulties in regulating emotions. However, direct empirical tests of such theoretical proposition are very thin. Aim: In view of this, the present study aims to investigate how and to what extent individual difference in hemispheric preference relate to emotion regulation. Materials and Methods: Thirty-two right-handed male subjects in the age range 18 to 20 years were assessed on self-report measures of hemispheric preference and emotion regulation difficulties. The correlation between dimensions of hemispheric preference and difficulties in regulating emotions was computed. A series of stepwise multiple regression analyses were also done to explore the relative significance of various dimensions of hemispheric preference in predicting emotion regulation difficulties. Results: The findings revealed that in general a preference for the right hemispheric mode of information processing was associated with greater emotion regulation difficulties. The correlation analysis indicated that while impulse control difficulties and difficulties in engaging goal directed behavior was associated with preference for almost all the right hemispheric mode of information processing, the nonacceptance of emotional responses and limited access to emotion regulation was related to preference for only global/synthetic (a right hemispheric) mode of information processing. Similarly, the lack of emotional clarity facet of emotion regulation difficulties correlated significantly with a preference for the emotional mode of information processing (again a right hemispheric mode). The results of stepwise multiple regression analyses, however, indicated that “nonacceptance of emotional responses’ and ‘limited access to emotion regulation strategies” facets of emotion regulation difficulties were best predicted by a preference for the global/synthetic mode of information processing. While others like difficulties engaging in goal-directed behaviour, impulse control difficulties, and lack of emotional clarity were best predicted by a preference for visuo-spatial rather than the verbal mode of information processing. Conclusion: Overall, the findings imply that greater preference for right hemispheric mode of information processing as compared to the left is associated with greater difficulties in regulating emotions. PMID:22969178

FAST TRACK COMMUNICATION Generation of stable multi-jets by flow-limited field-injection electrostatic spraying and their control via I-V characteristics

NASA Astrophysics Data System (ADS)

Gu, W.; Heil, P. E.; Choi, H.; Kim, K.

2010-12-01

The I-V characteristics of flow-limited field-injection electrostatic spraying (FFESS) were investigated, exposing a new way to predict and control the specific spraying modes from single-jet to multi-jet. Monitoring the I-V characteristics revealed characteristic drops in the current upon formation of an additional jet in the multi-jet spraying mode. For fixed jet numbers, space-charge-limited current behaviour was measured which was attributed to space charge in the dielectric liquids between the needle electrode and the nozzle opening. The present work establishes that FFESS can, in particular, generate stable multiple jets and that their control is possible through monitoring the I-V characteristics. This can allow for automatic control of the FFESS process and expedite its future scientific and industrial applications.

Ares Vallis Polygons

NASA Image and Video Library

2002-12-04

The jumble of eroded ridges and mesas seen in this NASA Mars Odyssey image occurs within Ares Vallis, one of the largest catastrophic outflow channels on the planet. Floods raged through this channel, pouring out into the Chryse Basin to the north. Close inspection of the THEMIS image reveals polygonal shapes on the floor of the channel system. Polygonal terrain on Mars is fairly common although the variety of forms and scales of the polygons suggests multiple modes of origin. Those in Ares Vallis resemble giant desiccation polygons that form in soils on Earth when a moist layer at depth drys out. While polygons can form in icy soils (permafrost) and even lava flows, their presence in a channel thought to have been carved by flowing water is at least consistent with a mode of origin that involved liquid water. http://photojournal.jpl.nasa.gov/catalog/PIA04019

Morphology selection for cupric oxide thin films by electrodeposition.

PubMed

Dhanasekaran, V; Mahalingam, T; Chandramohan, R

2011-10-01

Polycrystalline cupric oxide thin films were deposited using alkaline solution bath employing cathodic electrodeposition method. The thin films were electrodeposited at various solution pH. The surface morphology and elemental analyzes of the films were studied using scanning electron microscopy (SEM) and energy dispersive X-ray analysis, respectively. SEM studies revealed that the surface morphology could be tailored suitably by adjusting the pH value during deposition. Mesh average on multiple lattice mode atomic force microscopy image was obtained and reported. Copyright © 2011 Wiley-Liss, Inc.

Generation of Multiple Vortex Beams with Specified Vortex Number from Lasers with Controlled Ince-Gaussian Modes

NASA Astrophysics Data System (ADS)

Chu, Shu-Chun

2008-07-01

This study proposes a systematic method of selecting excitations of part of Ince-Gaussian modes (IGMs) and a three-lens configuration for generating multiple vortex beams with forced IGMs in the model of laser-diode (LD)-pumped solid-state lasers. Simply changing the lateral off-axis position of the tight pump beam focus on the laser crystal can produce the desired multiple optical vortex beam from the laser in a well-controlled manner using a proposed astigmatic mode converter assembled into one body with the laser cavity.

Three-Dimensional Structures Reveal Multiple ADP/ATP Binding Modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

C Simmons; C Magee; D Smith

The creation of synthetic enzymes with predefined functions represents a major challenge in future synthetic biology applications. Here, we describe six structures of de novo proteins that have been determined using protein crystallography to address how simple enzymes perform catalysis. Three structures are of a protein, DX, selected for its stability and ability to tightly bind ATP. Despite the addition of ATP to the crystallization conditions, the presence of a bound but distorted ATP was found only under excess ATP conditions, with ADP being present under equimolar conditions or when crystallized for a prolonged period of time. A bound ADPmore » cofactor was evident when Asp was substituted for Val at residue 65, but ATP in a linear configuration is present when Phe was substituted for Tyr at residue 43. These new structures complement previously determined structures of DX and the protein with the Phe 43 to Tyr substitution [Simmons, C. R., et al. (2009) ACS Chem. Biol. 4, 649-658] and together demonstrate the multiple ADP/ATP binding modes from which a model emerges in which the DX protein binds ATP in a configuration that represents a transitional state for the catalysis of ATP to ADP through a slow, metal-free reaction capable of multiple turnovers. This unusual observation suggests that design-free methods can be used to generate novel protein scaffolds that are tailor-made for catalysis.« less

Multiple Spacecraft Study of the Impact of Turbulence on Reconnection Rates

NASA Technical Reports Server (NTRS)

Wendel, Deirdre; Goldstein, Melvyn; Figueroa-Vinas, Adolfo; Adrian, Mark; Sahraoui, Fouad

2011-01-01

Magnetic turbulence and secondary island formation have reemerged as possible explanations for fast reconnection. Recent three-dimensional simulations reveal the formation of secondary islands that serve to shorten the current sheet and increase the accelerating electric field, while both simulations and observations witness electron holes whose collapse energizes electrons. However, few data studies have explicitly investigated the effect of turbulence and islands on the reconnection rate. We present a more comprehensive analysis of the effect of turbulence and islands on reconnection rates observed in space. Our approach takes advantage of multiple spacecraft to find the location of the spacecraft relative to the inflow and the outflow, to estimate the reconnection electric field, to indicate the presence and size of islands, and to determine wave vectors indicating turbulence. A superposed epoch analysis provides independent estimates of spatial scales and a reconnection electric field. We apply k-filtering and a new method adopted from seismological analyses to identify the wavevectors. From several case studies of reconnection events, we obtain preliminary estimates of the spectral scaling law, identify wave modes, and present a method for finding the reconnection electric field associated with the wave modes.

LEDs based upon AlGaInP heterostructures with multiple quantum wells: comparison of fast neutrons and gamma-quanta irradiation

NASA Astrophysics Data System (ADS)

Gradoboev, A. V.; Orlova, K. N.; Simonova, A. V.

2018-05-01

The paper presents the research results of watt and volt characteristics of LEDs based upon AlGaInP heterostructures with multiple quantum wells in the active region. The research is completed for LEDs (emission wavelengths 624 nm and 590 nm) under irradiation by fast neutron and gamma-quanta in passive powering mode. Watt-voltage characteristics in the average and high electron injection areas are described as a power function of the operating voltage. It has been revealed that the LEDs transition from average electron injection area to high electron injection area occurs by overcoming the transition area. It disappears as it get closer to the limit result of the irradiation LEDs that is low electron injection mode in the entire supply voltage range. It has been established that the gamma radiation facilitates initial defects restructuring only 42% compared to 100% when irradiation is performed by fast neutrons. Ratio between measured on the boundary between low and average electron injection areas current value and the contribution magnitude of the first stage LEDs emissive power reducing is established. It is allows to predict LEDs resistance to irradiation by fast neutrons and gamma rays.

Real-Time Feedback Control of Flow-Induced Cavity Tones. Part 2; Adaptive Control

NASA Technical Reports Server (NTRS)

Kegerise, M. A.; Cabell, R. H.; Cattafesta, L. N., III

2006-01-01

An adaptive generalized predictive control (GPC) algorithm was formulated and applied to the cavity flow-tone problem. The algorithm employs gradient descent to update the GPC coefficients at each time step. Past input-output data and an estimate of the open-loop pulse response sequence are all that is needed to implement the algorithm for application at fixed Mach numbers. Transient measurements made during controller adaptation revealed that the controller coefficients converged to a steady state in the mean, and this implies that adaptation can be turned off at some point with no degradation in control performance. When converged, the control algorithm demonstrated multiple Rossiter mode suppression at fixed Mach numbers ranging from 0.275 to 0.38. However, as in the case of fixed-gain GPC, the adaptive GPC performance was limited by spillover in sidebands around the suppressed Rossiter modes. The algorithm was also able to maintain suppression of multiple cavity tones as the freestream Mach number was varied over a modest range (0.275 to 0.29). Beyond this range, stable operation of the control algorithm was not possible due to the fixed plant model in the algorithm.

Geometric interpretations for resonances of plasmonic nanoparticles

NASA Astrophysics Data System (ADS)

Liu, Wei; Oulton, Rupert F.; Kivshar, Yuri S.

2015-07-01

The field of plasmonics can be roughly categorized into two branches: surface plasmon polaritons (SPPs) propagating in waveguides and localized surface plasmons (LSPs) supported by scattering particles. Investigations along these two directions usually employ different approaches, resulting in more or less a dogma that the two branches progress almost independently of each other, with few interactions. Here in this work we interpret LSPs from a Bohr model based geometric perspective relying on SPPs, thus establishing a connection between these two sub-fields. Besides the clear explanations of conventional scattering features of plasmonic nanoparticles, based on this geometric model we further demonstrate other anomalous scattering features (higher order modes supported at lower frequencies, and blueshift of the resonance with increasing particle sizes) and multiple electric resonances of the same order supported at different frequencies, which have been revealed to originate from backward SPP modes and multiple dispersion bands supported in the corresponding plasmonic waveguides, respectively. Inspired by this geometric model, it is also shown that, through solely geometric tuning, the absorption of each LSP resonance can be maximized to reach the single channel absorption limit, provided that the scattering and absorption rates are tuned to be equal.

Two-mode division multiplexing in a silicon-on-insulator ring resonator.

PubMed

Dorin, Bryce A; Ye, Winnie N

2014-02-24

Mode-division multiplexing (MDM) is an emerging multiple-input multiple-output method, utilizing multimode waveguides to increase channel numbers. In the past, silicon-on-insulator (SOI) devices have been primarily focused on single-mode waveguides. We present the design and fabrication of a two-mode SOI ring resonator for MDM systems. By optimizing the device parameters, we have ensured that each mode is treated equally within the ring. Using adiabatic Bezier curves in the ring bends, our ring demonstrated a signal-to-crosstalk ratio above 18 dB for both modes at the through and drop ports. We conclude that the ring resonator has the potential for filtering and switching for MDM systems on SOI.

Multiple detuned-resonator induced transparencies in MIM plasmonic waveguide

NASA Astrophysics Data System (ADS)

Liu, Li; Xia, Sheng-Xuan; Luo, Xin; Zhai, Xiang; Yu, Ya-Bin; Wang, Ling-Ling

2018-07-01

We propose a simple plasmonic waveguide system based on two-detuned resonators, which demonstrates multiple detuned-resonator induced transparencies at visible and near-infrared region. The performance of electromagnetic responses can be agile manipulated by tuning the asymmetry degree of the structure and the width of the split gap. Three transmission dips exist with the symmetrical design while three peaks emerge between the dip-position of the transmission spectra with two detuned resonators. The physical mechanism behind the plasmon-induced transparency (PIT) resonance is revealed as being attributed to the constructive interference between the confined modes in the detuned resonators. The former tend to the role of two coupled radiative oscillators. The work may open up avenues for the control of light in highly integrated optical circuits.

Component mode synthesis and large deflection vibration of complex structures. Volume 3: Multiple-mode nonlinear free and forced vibrations of beams using finite element method

NASA Technical Reports Server (NTRS)

Mei, Chuh; Shen, Mo-How

1987-01-01

Multiple-mode nonlinear forced vibration of a beam was analyzed by the finite element method. Inplane (longitudinal) displacement and inertia (IDI) are considered in the formulation. By combining the finite element method and nonlinear theory, more realistic models of structural response are obtained more easily and faster.

Two-step relaxation mode analysis with multiple evolution times applied to all-atom molecular dynamics protein simulation.

PubMed

Karasawa, N; Mitsutake, A; Takano, H

2017-12-01

Proteins implement their functionalities when folded into specific three-dimensional structures, and their functions are related to the protein structures and dynamics. Previously, we applied a relaxation mode analysis (RMA) method to protein systems; this method approximately estimates the slow relaxation modes and times via simulation and enables investigation of the dynamic properties underlying the protein structural fluctuations. Recently, two-step RMA with multiple evolution times has been proposed and applied to a slightly complex homopolymer system, i.e., a single [n]polycatenane. This method can be applied to more complex heteropolymer systems, i.e., protein systems, to estimate the relaxation modes and times more accurately. In two-step RMA, we first perform RMA and obtain rough estimates of the relaxation modes and times. Then, we apply RMA with multiple evolution times to a small number of the slowest relaxation modes obtained in the previous calculation. Herein, we apply this method to the results of principal component analysis (PCA). First, PCA is applied to a 2-μs molecular dynamics simulation of hen egg-white lysozyme in aqueous solution. Then, the two-step RMA method with multiple evolution times is applied to the obtained principal components. The slow relaxation modes and corresponding relaxation times for the principal components are much improved by the second RMA.

Two-step relaxation mode analysis with multiple evolution times applied to all-atom molecular dynamics protein simulation

NASA Astrophysics Data System (ADS)

Karasawa, N.; Mitsutake, A.; Takano, H.

2017-12-01

Proteins implement their functionalities when folded into specific three-dimensional structures, and their functions are related to the protein structures and dynamics. Previously, we applied a relaxation mode analysis (RMA) method to protein systems; this method approximately estimates the slow relaxation modes and times via simulation and enables investigation of the dynamic properties underlying the protein structural fluctuations. Recently, two-step RMA with multiple evolution times has been proposed and applied to a slightly complex homopolymer system, i.e., a single [n ] polycatenane. This method can be applied to more complex heteropolymer systems, i.e., protein systems, to estimate the relaxation modes and times more accurately. In two-step RMA, we first perform RMA and obtain rough estimates of the relaxation modes and times. Then, we apply RMA with multiple evolution times to a small number of the slowest relaxation modes obtained in the previous calculation. Herein, we apply this method to the results of principal component analysis (PCA). First, PCA is applied to a 2-μ s molecular dynamics simulation of hen egg-white lysozyme in aqueous solution. Then, the two-step RMA method with multiple evolution times is applied to the obtained principal components. The slow relaxation modes and corresponding relaxation times for the principal components are much improved by the second RMA.

Multiple spatial modes based QKD over marine free-space optical channels in the presence of atmospheric turbulence.

PubMed

Sun, Xiaole; Djordjevic, Ivan B; Neifeld, Mark A

2016-11-28

We investigate a multiple spatial modes based quantum key distribution (QKD) scheme that employs multiple independent parallel beams through a marine free-space optical channel over open ocean. This approach provides the potential to increase secret key rate (SKR) linearly with the number of channels. To improve the SKR performance, we describe a back-propagation mode (BPM) method to mitigate the atmospheric turbulence effects. Our simulation results indicate that the secret key rate can be improved significantly by employing the proposed BPM-based multi-channel QKD scheme.

Evolution of MHC class I genes in the endangered loggerhead sea turtle (Caretta caretta) revealed by 454 amplicon sequencing.

PubMed

Stiebens, Victor A; Merino, Sonia E; Chain, Frédéric J J; Eizaguirre, Christophe

2013-04-30

In evolutionary and conservation biology, parasitism is often highlighted as a major selective pressure. To fight against parasites and pathogens, genetic diversity of the immune genes of the major histocompatibility complex (MHC) are particularly important. However, the extensive degree of polymorphism observed in these genes makes it difficult to conduct thorough population screenings. We utilized a genotyping protocol that uses 454 amplicon sequencing to characterize the MHC class I in the endangered loggerhead sea turtle (Caretta caretta) and to investigate their evolution at multiple relevant levels of organization. MHC class I genes revealed signatures of trans-species polymorphism across several reptile species. In the studied loggerhead turtle individuals, it results in the maintenance of two ancient allelic lineages. We also found that individuals carrying an intermediate number of MHC class I alleles are larger than those with either a low or high number of alleles. Multiple modes of evolution seem to maintain MHC diversity in the loggerhead turtles, with relatively high polymorphism for an endangered species.

The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.

PubMed

Zelikowsky, Moriel; Hui, May; Karigo, Tomomi; Choe, Andrea; Yang, Bin; Blanco, Mario R; Beadle, Keith; Gradinaru, Viviana; Deverman, Benjamin E; Anderson, David J

2018-05-17

Chronic social isolation causes severe psychological effects in humans, but their neural bases remain poorly understood. 2 weeks (but not 24 hr) of social isolation stress (SIS) caused multiple behavioral changes in mice and induced brain-wide upregulation of the neuropeptide tachykinin 2 (Tac2)/neurokinin B (NkB). Systemic administration of an Nk3R antagonist prevented virtually all of the behavioral effects of chronic SIS. Conversely, enhancing NkB expression and release phenocopied SIS in group-housed mice, promoting aggression and converting stimulus-locked defensive behaviors to persistent responses. Multiplexed analysis of Tac2/NkB function in multiple brain areas revealed dissociable, region-specific requirements for both the peptide and its receptor in different SIS-induced behavioral changes. Thus, Tac2 coordinates a pleiotropic brain state caused by SIS via a distributed mode of action. These data reveal the profound effects of prolonged social isolation on brain chemistry and function and suggest potential new therapeutic applications for Nk3R antagonists. Copyright © 2018 Elsevier Inc. All rights reserved.

Interaction quenched ultracold few-boson ensembles in periodically driven lattices

NASA Astrophysics Data System (ADS)

Mistakidis, Simeon; Schmelcher, Peter; Theory Group of Fundamental Processes in Quantum Physics Team

2017-04-01

The out-of-equilibrium dynamics of interaction quenched finite ultracold bosonic ensembles in periodically driven one-dimensional optical lattices is investigated. It is shown that periodic driving enforces the bosons in the outer wells of the finite lattice to exhibit out-of-phase dipole-like modes, while in the central well the atomic cloud experiences a local breathing mode. The dynamical behavior is investigated with varying driving frequency, revealing a resonant-like behavior of the intra-well dynamics. An interaction quench in the periodically driven lattice gives rise to admixtures of different excitations in the outer wells, an enhanced breathing in the center and an amplification of the tunneling dynamics. We observe then multiple resonances between the inter- and intra-well dynamics at different quench amplitudes, with the position of the resonances being tunable via the driving frequency. Our results pave the way for future investigations on the use of combined driving protocols in order to excite different inter- and intra-well modes and to subsequently control them. Deutsche Forschungsgemeinschaft (DFG) in the framework of the SFB 925 ``Light induced dynamics and control of correlated quantum systems''.

Multiprocessor system with multiple concurrent modes of execution

DOEpatents

Ahn, Daniel; Ceze, Luis H; Chen, Dong; Gara, Alan; Heidelberger, Philip; Ohmacht, Martin

2013-12-31

A multiprocessor system supports multiple concurrent modes of speculative execution. Speculation identification numbers (IDs) are allocated to speculative threads from a pool of available numbers. The pool is divided into domains, with each domain being assigned to a mode of speculation. Modes of speculation include TM, TLS, and rollback. Allocation of the IDs is carried out with respect to a central state table and using hardware pointers. The IDs are used for writing different versions of speculative results in different ways of a set in a cache memory.

Multiprocessor system with multiple concurrent modes of execution

DOEpatents

Ahn, Daniel; Ceze, Luis H.; Chen, Dong Chen; Gara, Alan; Heidelberger, Philip; Ohmacht, Martin

2016-11-22

A multiprocessor system supports multiple concurrent modes of speculative execution. Speculation identification numbers (IDs) are allocated to speculative threads from a pool of available numbers. The pool is divided into domains, with each domain being assigned to a mode of speculation. Modes of speculation include TM, TLS, and rollback. Allocation of the IDs is carried out with respect to a central state table and using hardware pointers. The IDs are used for writing different versions of speculative results in different ways of a set in a cache memory.

Multiple polarization states of vector soliton in fiber laser

NASA Astrophysics Data System (ADS)

Chen, Weicheng; Xu, Wencheng; Cao, Hui; Han, Dingan

2007-11-01

Vector soliton is obtained in erbium-doped fiber laser via nonlinear polarization rotation techniques. In experiment, we observe the every 4- and 7-pulse sinusoidal peak modulation. Temporal pulse sinusoidal peak modulation owes to evolution behavior of vector solitons in multiple polarization states. The polarizer in the laser modulates the mode-locked pulses with different polarization states into periodical pulse train intensities modulation. Moreover, the increasing pumping power lead to the appearance of the harmonic pulses and change the equivalent beat length to accelerate the polarization rotation. When the laser cavity length is the n-th multiple ratios to the beat length to maintain the mode-locking, the mode-locked vector soliton is in n-th multiple polarization states, exhibiting every n-pulse sinusoidal peak modulation.

In-Depth View of the Structure and Growth of SnO2 Nanowires and Nanobrushes.

PubMed

Stuckert, Erin P; Geiss, Roy H; Miller, Christopher J; Fisher, Ellen R

2016-08-31

Strategic application of an array of complementary imaging and diffraction techniques is critical to determine accurate structural information on nanomaterials, especially when also seeking to elucidate structure-property relationships and their effects on gas sensors. In this work, SnO2 nanowires and nanobrushes grown via chemical vapor deposition (CVD) displayed the same tetragonal SnO2 structure as revealed via powder X-ray diffraction bulk crystallinity data. Additional characterization using a range of electron microscopy imaging and diffraction techniques, however, revealed important structure and morphology distinctions between the nanomaterials. Tailoring scanning transmission electron microscopy (STEM) modes combined with transmission electron backscatter diffraction (t-EBSD) techniques afforded a more detailed view of the SnO2 nanostructures. Indeed, upon deeper analysis of individual wires and brushes, we discovered that, despite a similar bulk structure, wires and brushes grew with different crystal faces and lattice spacings. Had we not utilized multiple STEM diffraction modes in conjunction with t-EBSD, differences in orientation related to bristle density would have been overlooked. Thus, it is only through a methodical combination of several structural analysis techniques that precise structural information can be reliably obtained.

A pricing approach for mitigating congestion in multimodal transportation systems.

DOT National Transportation Integrated Search

2010-02-19

The problem addressed in this research is to determine usage prices for a system with : multiple modes of transportation with the objective of reducing congestion. With multiple : modes, these prices can take on several forms. On road networks, the u...

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, Michael; Bautz, Marshall W.; Miller, Eric D.

We present new ultraviolet, optical, and X-ray data on the Phoenix galaxy cluster (SPT-CLJ2344-4243). Deep optical imaging reveals previously undetected filaments of star formation, extending to radii of ∼50–100 kpc in multiple directions. Combined UV-optical spectroscopy of the central galaxy reveals a massive (2 × 10{sup 9} M{sub ⊙}), young (∼4.5 Myr) population of stars, consistent with a time-averaged star formation rate of 610 ± 50 M{sub ⊙} yr{sup −1}. We report a strong detection of O vi λλ1032,1038, which appears to originate primarily in shock-heated gas, but may contain a substantial contribution (>1000 M{sub ⊙} yr{sup −1}) from themore » cooling intracluster medium (ICM). We confirm the presence of deep X-ray cavities in the inner ∼10 kpc, which are among the most extreme examples of radio-mode feedback detected to date, implying jet powers of 2–7 × 10{sup 45} erg s{sup −1}. We provide evidence that the active galactic nucleus inflating these cavities may have only recently transitioned from “quasar-mode” to “radio-mode,” and may currently be insufficient to completely offset cooling. A model-subtracted residual X-ray image reveals evidence for prior episodes of strong radio-mode feedback at radii of ∼100 kpc, with extended “ghost” cavities indicating a prior epoch of feedback roughly 100 Myr ago. This residual image also exhibits significant asymmetry in the inner ∼200 kpc (0.15R{sub 500}), reminiscent of infalling cool clouds, either due to minor mergers or fragmentation of the cooling ICM. Taken together, these data reveal a rapidly evolving cool core which is rich with structure (both spatially and in temperature), is subject to a variety of highly energetic processes, and yet is cooling rapidly and forming stars along thin, narrow filaments.« less

Screening molecular associations with lipid membranes using natural abundance 13C cross-polarization magic-angle spinning NMR and principal component analysis.

PubMed

Middleton, David A; Hughes, Eleri; Madine, Jillian

2004-08-11

We describe an NMR approach for detecting the interactions between phospholipid membranes and proteins, peptides, or small molecules. First, 1H-13C dipolar coupling profiles are obtained from hydrated lipid samples at natural isotope abundance using cross-polarization magic-angle spinning NMR methods. Principal component analysis of dipolar coupling profiles for synthetic lipid membranes in the presence of a range of biologically active additives reveals clusters that relate to different modes of interaction of the additives with the lipid bilayer. Finally, by representing profiles from multiple samples in the form of contour plots, it is possible to reveal statistically significant changes in dipolar couplings, which reflect perturbations in the lipid molecules at the membrane surface or within the hydrophobic interior.

Morphological and Electrochemical Characterization of Nanostructured Li 4Ti 5O 12 Electrodes Using Multiple Imaging Mode Synchrotron X-ray Computed Tomography

DOE PAGES

Kashkooli, Ali Ghorbani; Foreman, Evan; Farhad, Siamak; ...

2017-09-21

In this study, synchrotron X-ray computed tomography has been utilized using two different imaging modes, absorption and Zernike phase contrast, to reconstruct the real three-dimensional (3D) morphology of nanostructured Li 4Ti 5O 12 (LTO) electrodes. The morphology of the high atomic number active material has been obtained using the absorption contrast mode, whereas the percolated solid network composed of active material and carbon-doped polymer binder domain (CBD) has been obtained using the Zernike phase contrast mode. The 3D absorption contrast image revealed that some LTO nano-particles tend to agglomerate and form secondary micro-sized particles with varying degrees of sphericity. Themore » tortuosity of electrode’s pore and solid phases were found to have directional dependence, different from Bruggeman’s tortuosity commonly used in macro-homogeneous models. The electrode’s heterogeneous structure was investigated by developing a numerical model to simulate galvanostatic discharge process using the Zernike phase contrast mode. The inclusion of CBD in the Zernike phase contrast results in an integrated percolated network of active material and CBD that is highly suited for continuum modeling. As a result, the simulation results highlight the importance of using the real 3D geometry since the spatial distribution of physical and electrochemical properties have a strong non-uniformity due to microstructural heterogeneities.« less

Multiple Modes of Communication between Neurons and Oligodendrocyte Precursor Cells.

PubMed

Maldonado, Paloma P; Angulo, María Cecilia

2015-06-01

The surprising discovery of bona fide synapses between neurons and oligodendrocytes precursor cells (OPCs) 15 years ago placed these progenitors as real partners of neurons in the CNS. The role of these synapses has not been established yet, but a main hypothesis is that neuron-OPC synaptic activity is a signaling pathway controlling OPC proliferation/differentiation, influencing the myelination process. However, new evidences describing non-synaptic mechanisms of communication between neurons and OPCs have revealed that neuron-OPC interactions are more complex than expected. The activation of extrasynaptic receptors by ambient neurotransmitter or local spillover and the ability of OPCs to sense neuronal activity through a potassium channel suggest that distinct modes of communication mediate different functions of OPCs in the CNS. This review discusses different mechanisms used by OPCs to interact with neurons and their potential roles during postnatal development and in brain disorders. © The Author(s) 2014.

Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

PubMed Central

Schulte, Michael B; Draghi, Jeremy A; Plotkin, Joshua B; Andino, Raul

2015-01-01

Life history theory posits that the sequence and timing of events in an organism's lifespan are fine-tuned by evolution to maximize the production of viable offspring. In a virus, a life history strategy is largely manifested in its replication mode. Here, we develop a stochastic mathematical model to infer the replication mode shaping the structure and mutation distribution of a poliovirus population in an intact single infected cell. We measure production of RNA and poliovirus particles through the infection cycle, and use these data to infer the parameters of our model. We find that on average the viral progeny produced from each cell are approximately five generations removed from the infecting virus. Multiple generations within a single cell infection provide opportunities for significant accumulation of mutations per viral genome and for intracellular selection. DOI: http://dx.doi.org/10.7554/eLife.03753.001 PMID:25635405

Analyzing Tropical Waves Using the Parallel Ensemble Empirical Model Decomposition Method: Preliminary Results from Hurricane Sandy

NASA Technical Reports Server (NTRS)

Shen, Bo-Wen; Cheung, Samson; Li, Jui-Lin F.; Wu, Yu-ling

2013-01-01

In this study, we discuss the performance of the parallel ensemble empirical mode decomposition (EMD) in the analysis of tropical waves that are associated with tropical cyclone (TC) formation. To efficiently analyze high-resolution, global, multiple-dimensional data sets, we first implement multilevel parallelism into the ensemble EMD (EEMD) and obtain a parallel speedup of 720 using 200 eight-core processors. We then apply the parallel EEMD (PEEMD) to extract the intrinsic mode functions (IMFs) from preselected data sets that represent (1) idealized tropical waves and (2) large-scale environmental flows associated with Hurricane Sandy (2012). Results indicate that the PEEMD is efficient and effective in revealing the major wave characteristics of the data, such as wavelengths and periods, by sifting out the dominant (wave) components. This approach has a potential for hurricane climate study by examining the statistical relationship between tropical waves and TC formation.

Localized surface plasmon resonance properties of Ag nanorod arrays on graphene-coated Au substrate

NASA Astrophysics Data System (ADS)

Mu, Haiwei; Lv, Jingwei; Liu, Chao; Sun, Tao; Chu, Paul K.; Zhang, Jingping

2017-11-01

Localized surface plasmon resonance (LSPR) on silver nanorod (SNR) arrays deposited on a graphene-coated Au substrate is investigated by the discrete dipole approximation (DDA) method. The resonance peaks in the extinction spectra of the SNR/graphene/Au structure show significantly different profiles as SNR height, and refractive index of the surrounding medium are varied gradually. Numerical simulation reveals that the shifts in the resonance peaks arise from hybridization of multiple plasmon modes as a result of coupling between the SNR arrays and graphene-coated Au substrate. Moreover, the LSPR modes blue-shifts from 800 nm to 700 nm when the thickness of the graphene layer in the metal nanoparticle (NP) - graphene hybrid nanostructure increases from 1 nm to 5 nm, which attribute to charge transfer between the graphene layer and SNR arrays. The results provide insights into metal NP-graphene hybrid nanostructures which have potential applications in plasmonics.

Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics.

PubMed

Harris, Kenneth D; Hochgerner, Hannah; Skene, Nathan G; Magno, Lorenza; Katona, Linda; Bengtsson Gonzales, Carolina; Somogyi, Peter; Kessaris, Nicoletta; Linnarsson, Sten; Hjerling-Leffler, Jens

2018-06-18

Understanding any brain circuit will require a categorization of its constituent neurons. In hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to date. However, this list may be incomplete; additionally, it is unclear whether discrete classes are sufficient to describe the diversity of cortical inhibitory neurons or whether continuous modes of variability are also required. We studied the transcriptomes of 3,663 CA1 inhibitory cells, revealing 10 major GABAergic groups that divided into 49 fine-scale clusters. All previously described and several novel cell classes were identified, with three previously described classes unexpectedly found to be identical. A division into discrete classes, however, was not sufficient to describe the diversity of these cells, as continuous variation also occurred between and within classes. Latent factor analysis revealed that a single continuous variable could predict the expression levels of several genes, which correlated similarly with it across multiple cell types. Analysis of the genes correlating with this variable suggested it reflects a range from metabolically highly active faster-spiking cells that proximally target pyramidal cells to slower-spiking cells targeting distal dendrites or interneurons. These results elucidate the complexity of inhibitory neurons in one of the simplest cortical structures and show that characterizing these cells requires continuous modes of variation as well as discrete cell classes.

Quasi-distributed fiber sensor using active mode locking laser cavity with multiple FBG reflections

NASA Astrophysics Data System (ADS)

Park, Chang Hyun; Kim, Gyeong Hun; Kim, Chang-Seok; Lee, Hwi Don; Chung, Youngjoo

2017-04-01

We have demonstrated a quasi-distributed sensor using an active mode-locking (AML) laser with multiple fiber Bragg grating (FBG) reflections of the same center wavelength. We found that variations in the multiple cavity segment lengths between FBGs can be measured by simply sweeping the modulation frequency, because the modulation frequency of the AML laser is proportionally affected by cavity length.

Heat pump system with selective space cooling

DOEpatents

Pendergrass, J.C.

1997-05-13

A reversible heat pump provides multiple heating and cooling modes and includes a compressor, an evaporator and heat exchanger all interconnected and charged with refrigerant fluid. The heat exchanger includes tanks connected in series to the water supply and a condenser feed line with heat transfer sections connected in counterflow relationship. The heat pump has an accumulator and suction line for the refrigerant fluid upstream of the compressor. Sub-cool transfer tubes associated with the accumulator/suction line reclaim a portion of the heat from the heat exchanger. A reversing valve switches between heating/cooling modes. A first bypass is operative to direct the refrigerant fluid around the sub-cool transfer tubes in the space cooling only mode and during which an expansion valve is utilized upstream of the evaporator/indoor coil. A second bypass is provided around the expansion valve. A programmable microprocessor activates the first bypass in the cooling only mode and deactivates the second bypass, and vice-versa in the multiple heating modes for said heat exchanger. In the heating modes, the evaporator may include an auxiliary outdoor coil for direct supplemental heat dissipation into ambient air. In the multiple heating modes, the condensed refrigerant fluid is regulated by a flow control valve. 4 figs.

Heat pump system with selective space cooling

DOEpatents

Pendergrass, Joseph C.

1997-01-01

A reversible heat pump provides multiple heating and cooling modes and includes a compressor, an evaporator and heat exchanger all interconnected and charged with refrigerant fluid. The heat exchanger includes tanks connected in series to the water supply and a condenser feed line with heat transfer sections connected in counterflow relationship. The heat pump has an accumulator and suction line for the refrigerant fluid upstream of the compressor. Sub-cool transfer tubes associated with the accumulator/suction line reclaim a portion of the heat from the heat exchanger. A reversing valve switches between heating/cooling modes. A first bypass is operative to direct the refrigerant fluid around the sub-cool transfer tubes in the space cooling only mode and during which an expansion valve is utilized upstream of the evaporator/indoor coil. A second bypass is provided around the expansion valve. A programmable microprocessor activates the first bypass in the cooling only mode and deactivates the second bypass, and vice-versa in the multiple heating modes for said heat exchanger. In the heating modes, the evaporator may include an auxiliary outdoor coil for direct supplemental heat dissipation into ambient air. In the multiple heating modes, the condensed refrigerant fluid is regulated by a flow control valve.

Rigid-flexible coupling dynamic modeling and investigation of a redundantly actuated parallel manipulator with multiple actuation modes

NASA Astrophysics Data System (ADS)

Liang, Dong; Song, Yimin; Sun, Tao; Jin, Xueying

2017-09-01

A systematic dynamic modeling methodology is presented to develop the rigid-flexible coupling dynamic model (RFDM) of an emerging flexible parallel manipulator with multiple actuation modes. By virtue of assumed mode method, the general dynamic model of an arbitrary flexible body with any number of lumped parameters is derived in an explicit closed form, which possesses the modular characteristic. Then the completely dynamic model of system is formulated based on the flexible multi-body dynamics (FMD) theory and the augmented Lagrangian multipliers method. An approach of combining the Udwadia-Kalaba formulation with the hybrid TR-BDF2 numerical algorithm is proposed to address the nonlinear RFDM. Two simulation cases are performed to investigate the dynamic performance of the manipulator with different actuation modes. The results indicate that the redundant actuation modes can effectively attenuate vibration and guarantee higher dynamic performance compared to the traditional non-redundant actuation modes. Finally, a virtual prototype model is developed to demonstrate the validity of the presented RFDM. The systematic methodology proposed in this study can be conveniently extended for the dynamic modeling and controller design of other planar flexible parallel manipulators, especially the emerging ones with multiple actuation modes.

Design and characterization of 16-mode PANDA polarization-maintaining few-mode ring-core fiber for spatial division multiplexing

NASA Astrophysics Data System (ADS)

Cao, Yuan; Zhao, Yongli; Yu, Xiaosong; Han, Jiawei; Zhang, Jie

2017-11-01

A PANDA polarization-maintaining few-mode ring-core fiber (PM-FM-RCF) structure with two air holes around the ring core is proposed. The relative mode multiplicity factor (RMMF) is defined to evaluate the spatial efficiency of the designed PM-FM-RCF. The performance analysis and comparison of the proposed PANDA PM-FM-RCFs considering three different types of step-index profiles are detailed. Through modal characteristic analysis and numerical simulation, the PM-FM-RCF with a lower refractive index difference (Δnoi=1.5%) between the ring core and the inner central circle can support up to 16 polarization modes with large RMMF at C-band, which shows the optimum modal properties compared with the PM-FM-RCF with higher Δnoi. All the supported polarization modes are effectively separated from their adjacent polarization modes with effective refractive index differences (Δn) larger than 10-4, which also show relatively small chromatic dispersion (-20 to 25 ps/nm/km), low attenuation (<1.4 dB/km), and small bending radius (˜8 mm) over the C-band. The designed PM-FM-RCF can be compatible with standard single-mode fibers and applied in multiple-input multiple-output-free spatial division multiplexing optical networks for short-reach optical interconnection.

Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK*

PubMed Central

Landeta, Olatz; Landajuela, Ane; Garcia-Saez, Ana; Basañez, Gorka

2015-01-01

Proteins belonging to the BCL2 family are key modulators of apoptosis that establish a complex network of interactions among themselves and with other cellular factors to regulate cell fate. It is well established that mitochondrial membranes are the main locus of action of all BCL2 family proteins, but it is difficult to obtain a precise view of how BCL2 family members operate at the native mitochondrial membrane environment during apoptosis. Here, we used minimalist model systems and multiple fluorescence-based techniques to examine selected membrane activities of MCL1 and BAK under apoptotic-like conditions. We show that three distinct apoptosis-related factors (i.e. the BCL2 homology 3 ligand cBID, the mitochondrion-specific lipid cardiolipin, and membrane geometrical curvature) all promote membrane association of BCL2-like structural folds belonging to both MCL1 and BAK. However, at the same time, the two proteins exhibited distinguishing features in their membrane association modes under apoptotic-like conditions. In addition, scanning fluorescence cross-correlation spectroscopy and FRET measurements revealed that the BCL2-like structural fold of MCL1, but not that of BAK, forms stable heterodimeric complexes with cBID in a manner adjustable by membrane cardiolipin content and curvature degree. Our results add significantly to a growing body of evidence indicating that the mitochondrial membrane environment plays a complex and active role in the mode of action of BCL2 family proteins. PMID:25987560

Charging system with galvanic isolation and multiple operating modes

DOEpatents

Kajouke, Lateef A.; Perisic, Milun; Ransom, Ray M.

2013-01-08

Systems and methods are provided for operating a charging system with galvanic isolation adapted for multiple operating modes. A vehicle charging system comprises a DC interface, an AC interface, a first conversion module coupled to the DC interface, and a second conversion module coupled to the AC interface. An isolation module is coupled between the first conversion module and the second conversion module. The isolation module comprises a transformer and a switching element coupled between the transformer and the second conversion module. The transformer and the switching element are cooperatively configured for a plurality of operating modes, wherein each operating mode of the plurality of operating modes corresponds to a respective turns ratio of the transformer.

Monolithic integration of InGaAs/InP multiple quantum wells on SOI substrates for photonic devices

NASA Astrophysics Data System (ADS)

Li, Zhibo; Wang, Mengqi; Fang, Xin; Li, Yajie; Zhou, Xuliang; Yu, Hongyan; Wang, Pengfei; Wang, Wei; Pan, Jiaoqing

2018-02-01

A direct epitaxy of III-V nanowires with InGaAs/InP multiple quantum wells on v-shaped trenches patterned silicon on insulator (SOI) substrates was realized by combining the standard semiconductor fabrication process with the aspect ratio trapping growth technique. Silicon thickness as well as the width and gap of each nanowire were carefully designed to accommodate essential optical properties and appropriate growth conditions. The III-V element ingredient, crystalline quality, and surface topography of the grown nanowires were characterized by X-ray diffraction spectroscopy, photoluminescence, and scanning electron microscope. Geometrical details and chemical information of multiple quantum wells were revealed by transmission electron microscopy and energy dispersive spectroscopy. Numerical simulations confirmed that the optical guided mode supported by one single nanowire was able to propagate 50 μm with ˜30% optical loss. This proposed integration scheme opens up an alternative pathway for future photonic integrations of III-V devices on the SOI platform at nanoscale.

Design of elliptical-core mode-selective photonic lanterns with six modes for MIMO-free mode division multiplexing systems.

PubMed

Sai, Xiaowei; Li, Yan; Yang, Chen; Li, Wei; Qiu, Jifang; Hong, Xiaobin; Zuo, Yong; Guo, Hongxiang; Tong, Weijun; Wu, Jian

2017-11-01

Elliptical-core few mode fiber (EC-FMF) is used in a mode division multiplexing (MDM) transmission system to release multiple-input-multiple-output (MIMO) digital-signal-processing, which reduces the cost and the complexity of the receiver. However, EC-FMF does not match with conventional multiplexers/de-multiplexers (MUXs/DeMUXs) such as a photonic lantern, leading to extra mode coupling loss and crosstalk. We design elliptical-core mode-selective photonic lanterns (EC-MSPLs) with six modes, which can match well with EC-FMF in MIMO-free MDM systems. Simulation of the EC-MSPL using the beam propagation method was demonstrated employing a combination of either step-index or graded-index fibers with six different sizes of cores, and the taper transition length of 8 cm or 4 cm. Through numerical simulations and optimizations, both types of photonic lanterns can realize low loss transmission and low crosstalk of below -20.0  dB for all modes.

Analysis of Urinary Metabolites of Nerve and Blister Chemical Warfare Agents

DTIC Science & Technology

2014-08-01

of CWAs. The analysis methods use UHPLC-MS/MS in Multiple Reaction Monitoring ( MRM ) mode to enhance the selectivity and sensitivity of the method...Chromatography Mass Spectrometry LOD Limit Of Detection LOQ Limit of Quantitation MRM Multiple Reaction Monitoring MSMS Tandem mass...urine [1]. Those analysis methods use UHPLC- MS/MS in Multiple Reaction Monitoring ( MRM ) mode to enhance the selectivity and sensitivity of the method

Effect of exercise interventions on perceived fatigue in people with multiple sclerosis: synthesis of meta-analytic reviews.

PubMed

Safari, Reza; Van der Linden, Marietta L; Mercer, Tom H

2017-06-01

Although exercise training has been advocated as a nonpharmacological treatment for multiple sclerosis (MS) related fatigue, no consensus exists regarding its effectiveness. To address this, we collated meta-analytic reviews that explored the effectiveness of exercise training for the treatment of MS-related fatigue. We searched five online databases for relevant reviews, published since 2005, and identified 172 records. Five reviews were retained for systematic extraction of information and evidence quality analysis. Although our review synthesis indicated that exercise training interventions have a moderate effect on fatigue reduction in people with MS, no clear insight was obtained regarding the relative effectiveness of specific types or modes of exercise intervention. Moreover, Grading of Recommendation Assessment, Development and Evaluation revealed that the overall quality of evidence emanating from these five reviews was 'very low'.

Impact of stacking order on the microstructural properties of Cu2ZnGeSe4 thin film absorber layer

NASA Astrophysics Data System (ADS)

Mary, G. Swapna; Chandra, G. Hema; Sunil, M. Anantha; Subbaiah, Y. P. Venkata; Gupta, Mukul; Rao, R. Prasada

2018-05-01

Six possible multiple stacks of Cu-ZnSe-Ge with selenium incorporation at a precursor stage were prepared using electron beam evaporation followed by vacuum selenization at 475 °C for 30 min to investigate the role of stacking order on the growth and properties of Cu2ZnGeSe4 films. The X-ray diffraction measurements affirm the existence of various binary and ternary phases (ZnSe, Cu2Se, GeSe2 and Cu2GeSe3) for all the precursor stacks. These phases are completely diminished after selenization at 475 °C except a minor co-existence of ZnSe (111) phase along with dominant Cu2ZnGeSe4 (112) phase for stack A: (Cu/Se/ZnSe/Se/Ge/Se) × 4. The Raman measurements for selenized multiple stack A, revealed two major A3, A1 modes at 206 cm-1 and 176 cm-1 and one minor E5 mode at 270 cm-1 corresponding to CZGSe phase. The surface morphology and the elemental distribution across the thickness found to vary significantly with the change of stacking order. The selenized multiple stacks A films shows densely packed flake and capsule shaped grains. The selenized stack A found to have a direct energy band gap of 1.60 eV, showing p-type conductivity with a Hall mobility of 22 cm2 (Vs)-1.

GEODYN operations description, volume 3. [computer program for estimation of orbit and geodetic parameters

NASA Technical Reports Server (NTRS)

Martin, T. V.; Mullins, N. E.

1972-01-01

The operating and set-up procedures for the multi-satellite, multi-arc GEODYN- Orbit Determination program are described. All system output is analyzed. The GEODYN Program is the nucleus of the entire GEODYN system. It is a definitive orbit and geodetic parameter estimation program capable of simultaneously processing observations from multiple arcs of multiple satellites. GEODYN has two modes of operation: (1) the data reduction mode and (2) the orbit generation mode.

On Holo-Hilbert Spectral Analysis: A Full Informational Spectral Representation for Nonlinear and Non-Stationary Data

NASA Technical Reports Server (NTRS)

Huang, Norden E.; Hu, Kun; Yang, Albert C. C.; Chang, Hsing-Chih; Jia, Deng; Liang, Wei-Kuang; Yeh, Jia Rong; Kao, Chu-Lan; Juan, Chi-Huang; Peng, Chung Kang;

On Holo-Hilbert spectral analysis: a full informational spectral representation for nonlinear and non-stationary data

PubMed Central

Huang, Norden E.; Hu, Kun; Yang, Albert C. C.; Chang, Hsing-Chih; Jia, Deng; Liang, Wei-Kuang; Yeh, Jia Rong; Kao, Chu-Lan; Juan, Chi-Hung; Peng, Chung Kang; Meijer, Johanna H.; Wang, Yung-Hung; Long, Steven R.; Wu, Zhauhua

2016-01-01

The Holo-Hilbert spectral analysis (HHSA) method is introduced to cure the deficiencies of traditional spectral analysis and to give a full informational representation of nonlinear and non-stationary data. It uses a nested empirical mode decomposition and Hilbert–Huang transform (HHT) approach to identify intrinsic amplitude and frequency modulations often present in nonlinear systems. Comparisons are first made with traditional spectrum analysis, which usually achieved its results through convolutional integral transforms based on additive expansions of an a priori determined basis, mostly under linear and stationary assumptions. Thus, for non-stationary processes, the best one could do historically was to use the time–frequency representations, in which the amplitude (or energy density) variation is still represented in terms of time. For nonlinear processes, the data can have both amplitude and frequency modulations (intra-mode and inter-mode) generated by two different mechanisms: linear additive or nonlinear multiplicative processes. As all existing spectral analysis methods are based on additive expansions, either a priori or adaptive, none of them could possibly represent the multiplicative processes. While the earlier adaptive HHT spectral analysis approach could accommodate the intra-wave nonlinearity quite remarkably, it remained that any inter-wave nonlinear multiplicative mechanisms that include cross-scale coupling and phase-lock modulations were left untreated. To resolve the multiplicative processes issue, additional dimensions in the spectrum result are needed to account for the variations in both the amplitude and frequency modulations simultaneously. HHSA accommodates all the processes: additive and multiplicative, intra-mode and inter-mode, stationary and non-stationary, linear and nonlinear interactions. The Holo prefix in HHSA denotes a multiple dimensional representation with both additive and multiplicative capabilities. PMID:26953180

Exploring asynchronous brainstorming in large groups: a field comparison of serial and parallel subgroups.

PubMed

de Vreede, Gert-Jan; Briggs, Robert O; Reiter-Palmon, Roni

2010-04-01

The aim of this study was to compare the results of two different modes of using multiple groups (instead of one large group) to identify problems and develop solutions. Many of the complex problems facing organizations today require the use of very large groups or collaborations of groups from multiple organizations. There are many logistical problems associated with the use of such large groups, including the ability to bring everyone together at the same time and location. A field study involved two different organizations and compared productivity and satisfaction of group. The approaches included (a) multiple small groups, each completing the entire process from start to end and combining the results at the end (parallel mode); and (b) multiple subgroups, each building on the work provided by previous subgroups (serial mode). Groups using the serial mode produced more elaborations compared with parallel groups, whereas parallel groups produced more unique ideas compared with serial groups. No significant differences were found related to satisfaction with process and outcomes between the two modes. Preferred mode depends on the type of task facing the group. Parallel groups are more suited for tasks for which a variety of new ideas are needed, whereas serial groups are best suited when elaboration and in-depth thinking on the solution are required. Results of this research can guide the development of facilitated sessions of large groups or "teams of teams."

78 FR 59372 - Certain Multiple Mode Outdoor Grills and Parts Thererof; Institution of Investigation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-895] Certain Multiple Mode Outdoor Grills and Parts Thererof; Institution of Investigation AGENCY: U.S. International Trade Commission. ACTION: Notice. SUMMARY: Notice is hereby given that a complaint was filed with the U.S. International Trade...

Weighted Fuzzy Risk Priority Number Evaluation of Turbine and Compressor Blades Considering Failure Mode Correlations

NASA Astrophysics Data System (ADS)

Gan, Luping; Li, Yan-Feng; Zhu, Shun-Peng; Yang, Yuan-Jian; Huang, Hong-Zhong

2014-06-01

Failure mode, effects and criticality analysis (FMECA) and Fault tree analysis (FTA) are powerful tools to evaluate reliability of systems. Although single failure mode issue can be efficiently addressed by traditional FMECA, multiple failure modes and component correlations in complex systems cannot be effectively evaluated. In addition, correlated variables and parameters are often assumed to be precisely known in quantitative analysis. In fact, due to the lack of information, epistemic uncertainty commonly exists in engineering design. To solve these problems, the advantages of FMECA, FTA, fuzzy theory, and Copula theory are integrated into a unified hybrid method called fuzzy probability weighted geometric mean (FPWGM) risk priority number (RPN) method. The epistemic uncertainty of risk variables and parameters are characterized by fuzzy number to obtain fuzzy weighted geometric mean (FWGM) RPN for single failure mode. Multiple failure modes are connected using minimum cut sets (MCS), and Boolean logic is used to combine fuzzy risk priority number (FRPN) of each MCS. Moreover, Copula theory is applied to analyze the correlation of multiple failure modes in order to derive the failure probabilities of each MCS. Compared to the case where dependency among multiple failure modes is not considered, the Copula modeling approach eliminates the error of reliability analysis. Furthermore, for purpose of quantitative analysis, probabilities importance weight from failure probabilities are assigned to FWGM RPN to reassess the risk priority, which generalize the definition of probability weight and FRPN, resulting in a more accurate estimation than that of the traditional models. Finally, a basic fatigue analysis case drawn from turbine and compressor blades in aeroengine is used to demonstrate the effectiveness and robustness of the presented method. The result provides some important insights on fatigue reliability analysis and risk priority assessment of structural system under failure correlations.

Experimental study on the statistic characteristics of a 3x3 RF MIMO channel over a single conventional multimode fiber.

PubMed

Lei, Yi; Li, Jianqiang; Wu, Rui; Fan, Yuting; Fu, Songnian; Yin, Feifei; Dai, Yitang; Xu, Kun

2017-06-01

Based on the observed random fluctuation phenomenon of speckle pattern across multimode fiber (MMF) facet and received optical power distribution across three output ports, we experimentally investigate the statistic characteristics of a 3×3 radio frequency multiple-input multiple-output (MIMO) channel enabled by mode division multiplexing in a conventional 50 µm MMF using non-mode-selective three-dimensional waveguide photonic lanterns as mode multiplexer and demultiplexer. The impacts of mode coupling on the MIMO channel coefficients, channel matrix, and channel capacity have been analyzed over different fiber lengths. The results indicate that spatial multiplexing benefits from the greater fiber length with stronger mode coupling, despite a higher optical loss.

Mode division multiplexing using an orbital angular momentum mode sorter and MIMO-DSP over a graded-index few-mode optical fibre

PubMed Central

Huang, Hao; Milione, Giovanni; Lavery, Martin P. J.; Xie, Guodong; Ren, Yongxiong; Cao, Yinwen; Ahmed, Nisar; An Nguyen, Thien; Nolan, Daniel A.; Li, Ming-Jun; Tur, Moshe; Alfano, Robert R.; Willner, Alan E.

2015-01-01

Mode division multiplexing (MDM)– using a multimode optical fiber’s N spatial modes as data channels to transmit N independent data streams – has received interest as it can potentially increase optical fiber data transmission capacity N-times with respect to single mode optical fibers. Two challenges of MDM are (1) designing mode (de)multiplexers with high mode selectivity (2) designing mode (de)multiplexers without cascaded beam splitting’s 1/N insertion loss. One spatial mode basis that has received interest is that of orbital angular momentum (OAM) modes. In this paper, using a device referred to as an OAM mode sorter, we show that OAM modes can be (de)multiplexed over a multimode optical fiber with higher than −15 dB mode selectivity and without cascaded beam splitting’s 1/N insertion loss. As a proof of concept, the OAM modes of the LP11 mode group (OAM−1,0 and OAM+1,0), each carrying 20-Gbit/s polarization division multiplexed and quadrature phase shift keyed data streams, are transmitted 5km over a graded-index, few-mode optical fibre. Channel crosstalk is mitigated using 4 × 4 multiple-input-multiple-output digital-signal-processing with <1.5 dB power penalties at a bit-error-rate of 2 × 10−3. PMID:26450398

Mode division multiplexing using an orbital angular momentum mode sorter and MIMO-DSP over a graded-index few-mode optical fibre.

PubMed

Huang, Hao; Milione, Giovanni; Lavery, Martin P J; Xie, Guodong; Ren, Yongxiong; Cao, Yinwen; Ahmed, Nisar; An Nguyen, Thien; Nolan, Daniel A; Li, Ming-Jun; Tur, Moshe; Alfano, Robert R; Willner, Alan E

2015-10-09

Mode division multiplexing (MDM)- using a multimode optical fiber's N spatial modes as data channels to transmit N independent data streams - has received interest as it can potentially increase optical fiber data transmission capacity N-times with respect to single mode optical fibers. Two challenges of MDM are (1) designing mode (de)multiplexers with high mode selectivity (2) designing mode (de)multiplexers without cascaded beam splitting's 1/N insertion loss. One spatial mode basis that has received interest is that of orbital angular momentum (OAM) modes. In this paper, using a device referred to as an OAM mode sorter, we show that OAM modes can be (de)multiplexed over a multimode optical fiber with higher than -15 dB mode selectivity and without cascaded beam splitting's 1/N insertion loss. As a proof of concept, the OAM modes of the LP11 mode group (OAM-1,0 and OAM+1,0), each carrying 20-Gbit/s polarization division multiplexed and quadrature phase shift keyed data streams, are transmitted 5km over a graded-index, few-mode optical fibre. Channel crosstalk is mitigated using 4 × 4 multiple-input-multiple-output digital-signal-processing with <1.5 dB power penalties at a bit-error-rate of 2 × 10(-3).

Mode division multiplexing using an orbital angular momentum mode sorter and MIMO-DSP over a graded-index few-mode optical fibre

NASA Astrophysics Data System (ADS)

Huang, Hao; Milione, Giovanni; Lavery, Martin P. J.; Xie, Guodong; Ren, Yongxiong; Cao, Yinwen; Ahmed, Nisar; An Nguyen, Thien; Nolan, Daniel A.; Li, Ming-Jun; Tur, Moshe; Alfano, Robert R.; Willner, Alan E.

2015-10-01

Mode division multiplexing (MDM)- using a multimode optical fiber’s N spatial modes as data channels to transmit N independent data streams - has received interest as it can potentially increase optical fiber data transmission capacity N-times with respect to single mode optical fibers. Two challenges of MDM are (1) designing mode (de)multiplexers with high mode selectivity (2) designing mode (de)multiplexers without cascaded beam splitting’s 1/N insertion loss. One spatial mode basis that has received interest is that of orbital angular momentum (OAM) modes. In this paper, using a device referred to as an OAM mode sorter, we show that OAM modes can be (de)multiplexed over a multimode optical fiber with higher than -15 dB mode selectivity and without cascaded beam splitting’s 1/N insertion loss. As a proof of concept, the OAM modes of the LP11 mode group (OAM-1,0 and OAM+1,0), each carrying 20-Gbit/s polarization division multiplexed and quadrature phase shift keyed data streams, are transmitted 5km over a graded-index, few-mode optical fibre. Channel crosstalk is mitigated using 4 × 4 multiple-input-multiple-output digital-signal-processing with <1.5 dB power penalties at a bit-error-rate of 2 × 10-3.

Multiple harmonic frequencies resonant cavity design and half-scale prototype measurements for a fast kicker

DOE PAGES

Huang, Yulu; Wang, Haipeng; Wang, Shaoheng; ...

2016-12-09

Quarter wavelength resonator (QWR) based deflecting cavities with the capability of supporting multiple odd-harmonic modes have been developed for an ultrafast periodic kicker system in the proposed Jefferson Lab Electron Ion Collider (JLEIC, formerly MEIC). Previous work on the kicking pulse synthesis and the transverse beam dynamics tracking simulations show that a flat-top kicking pulse can be generated with minimal emittance growth during injection and circulation of the cooling electron bunches. This flat-top kicking pulse can be obtained when a DC component and 10 harmonic modes with appropriate amplitude and phase are combined together. To support 10 such harmonic modes,more » four QWR cavities are used with 5, 3, 1, and 1 modes, respectively. In the multiple-mode cavities, several slightly tapered segments of the inner conductor are introduced to tune the higher order deflecting modes to be harmonic, and stub tuners are used to fine tune each frequency to compensate for potential errors. In this paper, we summarize the electromagnetic design of the five-mode cavity, including the geometry optimization to get high transverse shunt impedance, the frequency tuning and sensitivity analysis, and the single loop coupler design for coupling to all of the harmonic modes. In particular we report on the design and fabrication of a half-scale copper prototype of this proof-of-principle five-odd-mode cavity, as well as the rf bench measurements. Lastly, we demonstrate mode superposition in this cavity experimentally, which illustrates the kicking pulse generation concept.« less

Analog nonlinear MIMO receiver for optical mode division multiplexing transmission.

PubMed

Spalvieri, Arnaldo; Boffi, Pierpaolo; Pecorino, Simone; Barletta, Luca; Magarini, Maurizio; Gatto, Alberto; Martelli, Paolo; Martinelli, Mario

2013-10-21

The complexity and the power consumption of digital signal processing are crucial issues in optical transmission systems based on mode division multiplexing and coherent multiple-input multiple-output (MIMO) processing at the receiver. In this paper the inherent characteristic of spatial separation between fiber modes is exploited, getting a MIMO system where joint demultiplexing and detection is based on spatially separated photodetectors. After photodetection, one has a MIMO system with nonlinear crosstalk between modes. The paper shows that the nonlinear crosstalk can be dealt with by a low-complexity and non-adaptive detection scheme, at least in the cases presented in the paper.

First-year medical students prefer multiple learning styles.

PubMed

Lujan, Heidi L; DiCarlo, Stephen E

2006-03-01

Students have preferences for the ways in which they receive information. The visual, auditory, reading/writing, kinesthetic (VARK) questionnaire identifies student's preferences for particular modes of information presentation. We administered the VARK questionnaire to our first-year medical students, and 166 of 250 students (66%) returned the completed questionnaire. Only 36.1% of the students preferred a single mode of information presentation. Among these students, 5.4% preferred visual (learning from graphs, charts, and flow diagrams), 4.8% preferred auditory (learning from speech), 7.8% preferred printed words (learning from reading and writing), and 18.1% preferred using all their senses (kinesthetics: learning from touch, hearing, smell, taste, and sight). In contrast, most students (63.8%) preferred multiple modes [2 modes (24.5%), 3 modes (32.1%), or 4 modes (43.4%)] of information presentation. Knowing the students preferred modes can 1) help provide instruction tailored to the student's individual preference, 2) overcome the predisposition to treat all students in a similar way, and 3) motivate teachers to move from their preferred mode(s) to using others.

Infrared laser spectroscopy of the n-propyl and i-propyl radicals: Stretch-bend Fermi coupling in the alkyl CH stretch region

DOE PAGES

Franke, Peter R.; Tabor, Daniel P.; Moradi, Christopher P.; ...

2016-12-13

The n-propyl and i-propyl radicals were generated in the gas phase via pyrolysis of n-butyl nitrite [CH 3(CH 2) 3ONO] and i-butyl nitrite [(CH 3) 2CHCH 2ONO], respectively. Nascent radicals were promptly solvated by a beam of He nanodroplets, and the infrared spectra of the radicals were recorded in the CH stretching region. Several previously unreported bands are observed between 2800 and 3150 cm –1. The CH stretching modes observed above 3000 cm –1 are in excellent agreement with CCSD(T) anharmonic frequencies computed using second-order vibrational perturbation theory. However, between 2800 and 3000 cm –1, the spectra of n- andmore » i-propyl radicals become congested and difficult to assign due to the presence of multiple anharmonic resonance polyads. To model the spectrally congested region, Fermi and Darling-Dennison resonances are treated explicitly using “dressed” Hamiltonians and CCSD(T) quartic force fields in the normal mode representation, and the agreement with experiment is less than satisfactory. Computations employing local mode effective Hamiltonians reveal the origin of the spectral congestion to be strong coupling between the high frequency CH stretching modes and the lower frequency CH n bending/scissoring motions. The most significant coupling is between stretches and bends localized on the same CH 2/CH 3 group. As a result, spectral simulations using the local mode approach are in excellent agreement with experiment.« less

Infrared laser spectroscopy of the n-propyl and i-propyl radicals: Stretch-bend Fermi coupling in the alkyl CH stretch region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Franke, Peter R.; Tabor, Daniel P.; Moradi, Christopher P.

The n-propyl and i-propyl radicals were generated in the gas phase via pyrolysis of n-butyl nitrite [CH 3(CH 2) 3ONO] and i-butyl nitrite [(CH 3) 2CHCH 2ONO], respectively. Nascent radicals were promptly solvated by a beam of He nanodroplets, and the infrared spectra of the radicals were recorded in the CH stretching region. Several previously unreported bands are observed between 2800 and 3150 cm –1. The CH stretching modes observed above 3000 cm –1 are in excellent agreement with CCSD(T) anharmonic frequencies computed using second-order vibrational perturbation theory. However, between 2800 and 3000 cm –1, the spectra of n- andmore » i-propyl radicals become congested and difficult to assign due to the presence of multiple anharmonic resonance polyads. To model the spectrally congested region, Fermi and Darling-Dennison resonances are treated explicitly using “dressed” Hamiltonians and CCSD(T) quartic force fields in the normal mode representation, and the agreement with experiment is less than satisfactory. Computations employing local mode effective Hamiltonians reveal the origin of the spectral congestion to be strong coupling between the high frequency CH stretching modes and the lower frequency CH n bending/scissoring motions. The most significant coupling is between stretches and bends localized on the same CH 2/CH 3 group. As a result, spectral simulations using the local mode approach are in excellent agreement with experiment.« less

Wake Instabilities Behind Discrete Roughness Elements in High Speed Boundary Layers

NASA Technical Reports Server (NTRS)

Choudhari, Meelan; Li, Fei; Chang, Chau-Lyan; Norris, Andrew; Edwards, Jack

2013-01-01

Computations are performed to study the flow past an isolated, spanwise symmetric roughness element in zero pressure gradient boundary layers at Mach 3.5 and 5.9, with an emphasis on roughness heights of less than 55 percent of the local boundary layer thickness. The Mach 5.9 cases include flow conditions that are relevant to both ground facility experiments and high altitude flight ("cold wall" case). Regardless of the Mach number, the mean flow distortion due to the roughness element is characterized by long-lived streamwise streaks in the roughness wake, which can support instability modes that did not exist in the absence of the roughness element. The higher Mach number cases reveal a variety of instability mode shapes with velocity fluctuations concentrated in different localized regions of high base flow shear. The high shear regions vary from the top of a mushroom shaped structure characterizing the centerline streak to regions that are concentrated on the sides of the mushroom. Unlike the Mach 3.5 case with nearly same values of scaled roughness height k/delta and roughness height Reynolds number Re(sub kk), the odd wake modes in both Mach 5.9 cases are significantly more unstable than the even modes of instability. Additional computations for a Mach 3.5 boundary layer indicate that the presence of a roughness element can also enhance the amplification of first mode instabilities incident from upstream. Interactions between multiple roughness elements aligned along the flow direction are also explored.

Using Spatial Multiple Regression to Identify Intrinsic Connectivity Networks Involved in Working Memory Performance

PubMed Central

Gordon, Evan M.; Stollstorff, Melanie; Vaidya, Chandan J.

2012-01-01

Many researchers have noted that the functional architecture of the human brain is relatively invariant during task performance and the resting state. Indeed, intrinsic connectivity networks (ICNs) revealed by resting-state functional connectivity analyses are spatially similar to regions activated during cognitive tasks. This suggests that patterns of task-related activation in individual subjects may result from the engagement of one or more of these ICNs; however, this has not been tested. We used a novel analysis, spatial multiple regression, to test whether the patterns of activation during an N-back working memory task could be well described by a linear combination of ICNs delineated using Independent Components Analysis at rest. We found that across subjects, the cingulo-opercular Set Maintenance ICN, as well as right and left Frontoparietal Control ICNs, were reliably activated during working memory, while Default Mode and Visual ICNs were reliably deactivated. Further, involvement of Set Maintenance, Frontoparietal Control, and Dorsal Attention ICNs was sensitive to varying working memory load. Finally, the degree of left Frontoparietal Control network activation predicted response speed, while activation in both left Frontoparietal Control and Dorsal Attention networks predicted task accuracy. These results suggest that a close relationship between resting-state networks and task-evoked activation is functionally relevant for behavior, and that spatial multiple regression analysis is a suitable method for revealing that relationship. PMID:21761505

A Novel Approach to Beam Steering Using Arrays Composed of Multiple Unique Radiating Modes

NASA Astrophysics Data System (ADS)

Labadie, Nathan Richard

Phased array antennas have found wide application in both radar and wireless communications systems particularly as implementation costs continue to decrease. The primary advantages of electronically scanned arrays are speed of beam scan and versatility of beamforming compared to mechanically scanned fixed beam antennas. These benefits come at the cost of a few well known design issues including element pattern rolloff and mutual coupling between elements. Our primary contribution to the field of research is the demonstration of significant improvement in phased array scan performance using multiple unique radiating modes. In short, orthogonal radiating modes have minimal coupling by definition and can also be generated with reduced rolloff at wide scan angles. In this dissertation, we present a combination of analysis, full-wave electromagnetic simulation and measured data to support our claims. The novel folded ring resonator (FRR) antenna is introduced as a wideband and multi-band element embedded in a grounded dielectric substrate. Multiple radiating modes of a small ground plane excited by a four element FRR array were also investigated. A novel hemispherical null steering antenna composed of two collocated radiating elements, each supporting a unique radiating mode, is presented in the context of an anti-jam GPS receiver application. Both the antenna aperture and active feed network were fabricated and measured showing excellent agreement with analytical and simulated data. The concept of using an antenna supporting multiple radiating modes for beam steering is also explored. A 16 element hybrid linear phased array was fabricated and measured demonstrating significantly improved scan range and scanned gain compared to a conventional phased array. This idea is expanded to 2 dimensional scanning arrays by analysis and simulation of a hybrid phased array composed of novel multiple mode monopole on patch antenna sub-arrays. Finally, we fabricated and characterized the 2D scanning hybrid phased array demonstrating wide angle scanning with high antenna efficiency.

A Tabu-Search Heuristic for Deterministic Two-Mode Blockmodeling of Binary Network Matrices.

PubMed

Brusco, Michael; Steinley, Douglas

2011-10-01

Two-mode binary data matrices arise in a variety of social network contexts, such as the attendance or non-attendance of individuals at events, the participation or lack of participation of groups in projects, and the votes of judges on cases. A popular method for analyzing such data is two-mode blockmodeling based on structural equivalence, where the goal is to identify partitions for the row and column objects such that the clusters of the row and column objects form blocks that are either complete (all 1s) or null (all 0s) to the greatest extent possible. Multiple restarts of an object relocation heuristic that seeks to minimize the number of inconsistencies (i.e., 1s in null blocks and 0s in complete blocks) with ideal block structure is the predominant approach for tackling this problem. As an alternative, we propose a fast and effective implementation of tabu search. Computational comparisons across a set of 48 large network matrices revealed that the new tabu-search heuristic always provided objective function values that were better than those of the relocation heuristic when the two methods were constrained to the same amount of computation time.

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.

PubMed

Cuozzo, John W; Centrella, Paolo A; Gikunju, Diana; Habeshian, Sevan; Hupp, Christopher D; Keefe, Anthony D; Sigel, Eric A; Soutter, Holly H; Thomson, Heather A; Zhang, Ying; Clark, Matthew A

2017-05-04

We have identified and characterized novel potent inhibitors of Bruton's tyrosine kinase (BTK) from a single DNA-encoded library of over 110 million compounds by using multiple parallel selection conditions, including variation in target concentration and addition of known binders to provide competition information. Distinct binding profiles were observed by comparing enrichments of library building block combinations under these conditions; one enriched only at high concentrations of BTK and was competitive with ATP, and another enriched at both high and low concentrations of BTK and was not competitive with ATP. A compound representing the latter profile showed low nanomolar potency in biochemical and cellular BTK assays. Results from kinetic mechanism of action studies were consistent with the selection profiles. Analysis of the co-crystal structure of the most potent compound demonstrated a novel binding mode that revealed a new pocket in BTK. Our results demonstrate that profile-based selection strategies using DNA-encoded libraries form the basis of a new methodology to rapidly identify small molecule inhibitors with novel binding modes to clinically relevant targets. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Global Motions of the Nuclear Pore Complex: Insights from Elastic Network Models

PubMed Central

Lezon, Timothy R.; Sali, Andrej; Bahar, Ivet

2009-01-01

The nuclear pore complex (NPC) is the gate to the nucleus. Recent determination of the configuration of proteins in the yeast NPC at ∼5 nm resolution permits us to study the NPC global dynamics using coarse-grained structural models. We investigate these large-scale motions by using an extended elastic network model (ENM) formalism applied to several coarse-grained representations of the NPC. Two types of collective motions (global modes) are predicted by the ENMs to be intrinsically favored by the NPC architecture: global bending and extension/contraction from circular to elliptical shapes. These motions are shown to be robust against tested variations in the representation of the NPC, and are largely captured by a simple model of a toroid with axially varying mass density. We demonstrate that spoke multiplicity significantly affects the accessible number of symmetric low-energy modes of motion; the NPC-like toroidal structures composed of 8 spokes have access to highly cooperative symmetric motions that are inaccessible to toroids composed of 7 or 9 spokes. The analysis reveals modes of motion that may facilitate macromolecular transport through the NPC, consistent with previous experimental observations. PMID:19730674

Global motions of the nuclear pore complex: insights from elastic network models.

PubMed

Lezon, Timothy R; Sali, Andrej; Bahar, Ivet

2009-09-01

The nuclear pore complex (NPC) is the gate to the nucleus. Recent determination of the configuration of proteins in the yeast NPC at approximately 5 nm resolution permits us to study the NPC global dynamics using coarse-grained structural models. We investigate these large-scale motions by using an extended elastic network model (ENM) formalism applied to several coarse-grained representations of the NPC. Two types of collective motions (global modes) are predicted by the ENMs to be intrinsically favored by the NPC architecture: global bending and extension/contraction from circular to elliptical shapes. These motions are shown to be robust against tested variations in the representation of the NPC, and are largely captured by a simple model of a toroid with axially varying mass density. We demonstrate that spoke multiplicity significantly affects the accessible number of symmetric low-energy modes of motion; the NPC-like toroidal structures composed of 8 spokes have access to highly cooperative symmetric motions that are inaccessible to toroids composed of 7 or 9 spokes. The analysis reveals modes of motion that may facilitate macromolecular transport through the NPC, consistent with previous experimental observations.

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

PubMed Central

Wu, Wen-I; Voegtli, Walter C.; Sturgis, Hillary L.; Dizon, Faith P.; Vigers, Guy P. A.; Brandhuber, Barbara J.

2010-01-01

AKT1 (NP_005154.2) is a member of the serine/threonine AGC protein kinase family involved in cellular metabolism, growth, proliferation and survival. The three human AKT isozymes are highly homologous multi-domain proteins with both overlapping and distinct cellular functions. Dysregulation of the AKT pathway has been identified in multiple human cancers. Several clinical trials are in progress to test the efficacy of AKT pathway inhibitors in treating cancer. Recently, a series of AKT isozyme-selective allosteric inhibitors have been reported. They require the presence of both the pleckstrin-homology (PH) and kinase domains of AKT, but their binding mode has not yet been elucidated. We present here a 2.7 Å resolution co-crystal structure of human AKT1 containing both the PH and kinase domains with a selective allosteric inhibitor bound in the interface. The structure reveals the interactions between the PH and kinase domains, as well as the critical amino residues that mediate binding of the inhibitor to AKT1. Our work also reveals an intricate balance in the enzymatic regulation of AKT, where the PH domain appears to lock the kinase in an inactive conformation and the kinase domain disrupts the phospholipid binding site of the PH domain. This information advances our knowledge in AKT1 structure and regulation, thereby providing a structural foundation for interpreting the effects of different classes of AKT inhibitors and designing selective ones. PMID:20886116

Splice loss requirements in multi-mode fiber mode-division-multiplex transmission links.

PubMed

Warm, Stefan; Petermann, Klaus

2013-01-14

We investigate numerically the influence of fiber splices and fiber connectors to the statistics of mode dependent loss (MDL) and multiple-input multiple-output (MIMO) outage capacity in mode multiplexed multi-mode fiber links. Our results indicate required splice losses much lower than currently feasible to achieve a reasonable outage capacity in long-haul transmission systems. Splice losses as low as 0.03dB may effectively lead to an outage of MIMO channels after only a few hundred kilometers transmission length. In a first approximation, the relative capacity solely depends on the accumulated splice loss and should be less than ≈ 2dB to ensure a relative capacity of 90%. We also show that discrete mode permutation (mixing) within the transmission line may effectively increase the maximum transmission distance by a factor of 5 for conventional splice losses.

Stellar wind variations in HD 45166: The continuing story. [Wolf-Rayet star

NASA Technical Reports Server (NTRS)

Willis, Allan J.; Stickland, David J.; Heap, Sara R.

1988-01-01

High resolution SWP IUE spectra of HD 45166 (qWR+B8V) obtained over a 36 hr continuous run, together with earlier observations, reveal 2 distinct modes of UV variability in this object. Gross, epoch-linked changes are seen in the strengths of the qWR emission lines, accompanied by large changes in its highly ionized photospheric absorption spectrum. Rapid (hours) variability in strong, multiple, high velocity, wind discrete absorption components (DAC), in the CIV lambda 1550 resonance lines, which superpose to give the appearance of a broad P Cygni absorption profile at many epochs is also observed. These multiple DAC's (often at least 3 are seen) propagate in velocity, from 0.6 to 1.0 v inf, on a timescale of 1 day, implying an acceleration of 180 cm/s comparable to that seen in O-type stars.

A multivariate test of disease risk reveals conditions leading to disease amplification.

PubMed

Halliday, Fletcher W; Heckman, Robert W; Wilfahrt, Peter A; Mitchell, Charles E

2017-10-25

Theory predicts that increasing biodiversity will dilute the risk of infectious diseases under certain conditions and will amplify disease risk under others. Yet, few empirical studies demonstrate amplification. This contrast may occur because few studies have considered the multivariate nature of disease risk, which includes richness and abundance of parasites with different transmission modes. By combining a multivariate statistical model developed for biodiversity-ecosystem-multifunctionality with an extensive field manipulation of host (plant) richness, composition and resource supply to hosts, we reveal that (i) host richness alone could not explain most changes in disease risk, and (ii) shifting host composition allowed disease amplification, depending on parasite transmission mode. Specifically, as predicted from theory, the effect of host diversity on parasite abundance differed for microbes (more density-dependent transmission) and insects (more frequency-dependent transmission). Host diversity did not influence microbial parasite abundance, but nearly doubled insect parasite abundance, and this amplification effect was attributable to variation in host composition. Parasite richness was reduced by resource addition, but only in species-rich host communities. Overall, this study demonstrates that multiple drivers, related to both host community and parasite characteristics, can influence disease risk. Furthermore, it provides a framework for evaluating multivariate disease risk in other systems. © 2017 The Author(s).

Detection and estimation of defects in a circular plate using operational deflection shapes

NASA Astrophysics Data System (ADS)

Pai, Perngjin F.; Oh, Yunje; Kim, Byeong-Seok

2002-06-01

This paper investigates dynamic characteristics (mode shapes and natural frequencies) and defect detection of circular plates using a scanning laser vibrometer. Exact dynamic characteristics of a circular aluminum plate having a clamped inner rim and a free outer rim are obtained using two methods; one uses Bessel functions and the other uses a multiple shooting method. An in-house finite element code GESA is also used to analyze the circular plate using the DKT plate element. Numerical results show that some reports in the literature are incorrect and that high-frequency Operational Deflection Shapes (ODSs) are needed in order to locate small defects. Detection of two defects in the circular aluminum plate is experimentally studied using the distributions of RMS velocities under broadband periodic chirp excitations. RMS velocities of ODSs, symmetry breaking of ODSs, splitting of natural frequencies and ODSs, and a Boundary Effect Detection (BED) method. The BED method is non-destructive and model-independent; it processes experimental ODSs to reveal extra local boundary effects caused by defects to reveal locations of defects. Experimental results show that small defects in circular plates can be pinpointed by these approaches. Moreover, a new concept of using the balance of elastic and kinetic energies within a mode cell for detecting defects in two- dimensional structures of irregular shapes is proposed.

Cognition of an expert tackling an unfamiliar conceptual physics problem

NASA Astrophysics Data System (ADS)

Schuster, David; Undreiu, Adriana

2009-11-01

We have investigated and analyzed the cognition of an expert tackling a qualitative conceptual physics problem of an unfamiliar type. Our goal was to elucidate the detailed cognitive processes and knowledge elements involved, irrespective of final solution form, and consider implications for instruction. The basic but non-trivial problem was to find qualitatively the direction of acceleration of a pendulum bob at various stages of its motion, a problem originally studied by Reif and Allen. Methodology included interviews, introspection, retrospection and self-reported metacognition. Multiple facets of cognition were revealed, with different reasoning strategies used at different stages and for different points on the path. An account is given of the zigzag thinking paths and interplay of reasoning modes and schema elements involved. We interpret the cognitive processes in terms of theoretical concepts that emerged, namely: case-based, principle-based, experiential-intuitive and practical-heuristic reasoning; knowledge elements and schemata; activation; metacognition and epistemic framing. The complexity of cognition revealed in this case study contrasts with the tidy principle-based solutions we present to students. The pervasive role of schemata, case-based reasoning, practical heuristic strategies, and their interplay with physics principles is noteworthy, since these aspects of cognition are generally neither recognized nor taught. The schema/reasoning-mode perspective has direct application in science teaching, learning and problem-solving.

Brain system for mental orientation in space, time, and person.

PubMed

Peer, Michael; Salomon, Roy; Goldberg, Ilan; Blanke, Olaf; Arzy, Shahar

2015-09-01

Orientation is a fundamental mental function that processes the relations between the behaving self to space (places), time (events), and person (people). Behavioral and neuroimaging studies have hinted at interrelations between processing of these three domains. To unravel the neurocognitive basis of orientation, we used high-resolution 7T functional MRI as 16 subjects compared their subjective distance to different places, events, or people. Analysis at the individual-subject level revealed cortical activation related to orientation in space, time, and person in a precisely localized set of structures in the precuneus, inferior parietal, and medial frontal cortex. Comparison of orientation domains revealed a consistent order of cortical activity inside the precuneus and inferior parietal lobes, with space orientation activating posterior regions, followed anteriorly by person and then time. Core regions at the precuneus and inferior parietal lobe were activated for multiple orientation domains, suggesting also common processing for orientation across domains. The medial prefrontal cortex showed a posterior activation for time and anterior for person. Finally, the default-mode network, identified in a separate resting-state scan, was active for all orientation domains and overlapped mostly with person-orientation regions. These findings suggest that mental orientation in space, time, and person is managed by a specific brain system with a highly ordered internal organization, closely related to the default-mode network.

Constructing Standards: A Study of Nurses Negotiating with Multiple Modes of Knowledge

ERIC Educational Resources Information Center

Nes, Sturle; Moen, Anne

2010-01-01

Purpose: The aim of the paper is to explore how multiple modes of knowledge play out in the consolidation of nursing procedures in construction of "local universality". The paper seeks to explore processes where nurses negotiate universal procedures that are to become local standards in a hospital. Design/methodology/approach: The paper…

The Mediating Effect of Context Variation in Mixed Practice for Transfer of Basic Science

ERIC Educational Resources Information Center

Kulasegaram, Kulamakan; Min, Cynthia; Howey, Elizabeth; Neville, Alan; Woods, Nicole; Dore, Kelly; Norman, Geoffrey

2015-01-01

Applying a previously learned concept to a novel problem is an important but difficult process called transfer. Practicing multiple concepts together (mixed practice mode) has been shown superior to practicing concepts separately (blocked practice mode) for transfer. This study examined the effect of single and multiple practice contexts for both…

Multimodal Likelihoods in Educational Assessment: Will the Real Maximum Likelihood Score Please Stand up?

ERIC Educational Resources Information Center

Wothke, Werner; Burket, George; Chen, Li-Sue; Gao, Furong; Shu, Lianghua; Chia, Mike

2011-01-01

It has been known for some time that item response theory (IRT) models may exhibit a likelihood function of a respondent's ability which may have multiple modes, flat modes, or both. These conditions, often associated with guessing of multiple-choice (MC) questions, can introduce uncertainty and bias to ability estimation by maximum likelihood…

Nanoscale plasmonic phenomena in CVD-grown MoS 2 monolayer revealed by ultra-broadband synchrotron radiation based nano-FTIR spectroscopy and near-field microscopy

DOE PAGES

Patoka, Piotr; Ulrich, Georg; Nguyen, Ariana E.; ...

2016-01-13

Here, nanoscale plasmonic phenomena observed in single and bi-layers of molybdenum disulfide (MoS 2) on silicon dioxide (SiO 2) are reported. A scattering type scanning near-field optical microscope (s-SNOM) with a broadband synchrotron radiation (SR) infrared source was used. We also present complementary optical mapping using tunable CO 2-laser radiation. Specifically, there is a correlation of the topography of well-defined MoS 2 islands grown by chemical vapor deposition, as determined by atomic force microscopy, with the infrared (IR) signature of MoS 2. The influence of MoS 2 islands on the SiO 2 phonon resonance is discussed. The results reveal themore » plasmonic character of the MoS 2 structures and their interaction with the SiO 2 phonons leading to an enhancement of the hybridized surface plasmon-phonon mode. A theoretical analysis shows that, in the case of monolayer islands, the coupling of the MoS 2 optical plasmon mode to the SiO 2 surface phonons does not affect the infrared spectrum significantly. For two-layer MoS 2, the coupling of the extra inter-plane acoustic plasmon mode with the SiO 2 surface transverse phonon leads to a remarkable increase of the surface phonon peak at 794 cm -1. This is in agreement with the experimental data. These results show the capability of the s-SNOM technique to study local multiple excitations in complex non-homogeneous structures.« less

Efficient vibration mode analysis of aircraft with multiple external store configurations

NASA Technical Reports Server (NTRS)

Karpel, M.

1988-01-01

A coupling method for efficient vibration mode analysis of aircraft with multiple external store configurations is presented. A set of low-frequency vibration modes, including rigid-body modes, represent the aircraft. Each external store is represented by its vibration modes with clamped boundary conditions, and by its rigid-body inertial properties. The aircraft modes are obtained from a finite-element model loaded by dummy rigid external stores with fictitious masses. The coupling procedure unloads the dummy stores and loads the actual stores instead. The analytical development is presented, the effects of the fictitious mass magnitudes are discussed, and a numerical example is given for a combat aircraft with external wing stores. Comparison with vibration modes obtained by a direct (full-size) eigensolution shows very accurate coupling results. Once the aircraft and stores data bases are constructed, the computer time for analyzing any external store configuration is two to three orders of magnitude less than that of a direct solution.

Reusable Launch Vehicle Control in Multiple Time Scale Sliding Modes

NASA Technical Reports Server (NTRS)

Shtessel, Yuri

1999-01-01

A reusable launch vehicle control problem during ascent is addressed via multiple-time scaled continuous sliding mode control. The proposed sliding mode controller utilizes a two-loop structure and provides robust, de-coupled tracking of both orientation angle command profiles and angular rate command profiles in the presence of bounded external disturbances and plant uncertainties. Sliding mode control causes the angular rate and orientation angle tracking error dynamics to be constrained to linear, de-coupled, homogeneous, and vector valued differential equations with desired eigenvalues placement. The dual-time scale sliding mode controller was designed for the X-33 technology demonstration sub-orbital launch vehicle in the launch mode. 6DOF simulation results show that the designed controller provides robust, accurate, de-coupled tracking of the orientation angle command profiles in presence of external disturbances and vehicle inertia uncertainties. It creates possibility to operate the X-33 vehicle in an aircraft-like mode with reduced pre-launch adjustment of the control system.

Spatial-mode switchable ring fiber laser based on low mode-crosstalk all-fiber mode MUX/DEMUX

NASA Astrophysics Data System (ADS)

Ren, Fang; Yu, Jinyi; Wang, Jianping

2018-05-01

We report an all-fiber ring laser that emits linearly polarized (LP) modes based on the intracavity all-fiber mode multiplexer/demultiplexer (MUX/DEMUX). Multiple LP modes in ring fiber laser are generated by taking advantage of mode MUX/DEMUX. The all-fiber mode MUX/DEMUX are composed of cascaded mode-selective couplers (MSCs). The output lasing mode of the ring fiber laser can be switched among the three lowest-order LP modes by employing combination of a mode MUX and a simple N × 1 optical switch. The slope efficiencies, optical spectra and mode profiles are measured.

Multimodal, high-dimensional, model-based, Bayesian inverse problems with applications in biomechanics

NASA Astrophysics Data System (ADS)

Franck, I. M.; Koutsourelakis, P. S.

2017-01-01

This paper is concerned with the numerical solution of model-based, Bayesian inverse problems. We are particularly interested in cases where the cost of each likelihood evaluation (forward-model call) is expensive and the number of unknown (latent) variables is high. This is the setting in many problems in computational physics where forward models with nonlinear PDEs are used and the parameters to be calibrated involve spatio-temporarily varying coefficients, which upon discretization give rise to a high-dimensional vector of unknowns. One of the consequences of the well-documented ill-posedness of inverse problems is the possibility of multiple solutions. While such information is contained in the posterior density in Bayesian formulations, the discovery of a single mode, let alone multiple, poses a formidable computational task. The goal of the present paper is two-fold. On one hand, we propose approximate, adaptive inference strategies using mixture densities to capture multi-modal posteriors. On the other, we extend our work in [1] with regard to effective dimensionality reduction techniques that reveal low-dimensional subspaces where the posterior variance is mostly concentrated. We validate the proposed model by employing Importance Sampling which confirms that the bias introduced is small and can be efficiently corrected if the analyst wishes to do so. We demonstrate the performance of the proposed strategy in nonlinear elastography where the identification of the mechanical properties of biological materials can inform non-invasive, medical diagnosis. The discovery of multiple modes (solutions) in such problems is critical in achieving the diagnostic objectives.

Trophic Mode-Dependent Proteomic Analysis Reveals Functional Significance of Light-Independent Chlorophyll Synthesis in Synechocystis sp. PCC 6803.

PubMed

Fang, Longfa; Ge, Haitao; Huang, Xiahe; Liu, Ye; Lu, Min; Wang, Jinlong; Chen, Weiyang; Xu, Wu; Wang, Yingchun

2017-01-09

The photosynthetic model organism Synechocystis sp. PCC 6803 can grow in different trophic modes, depending on the availability of light and exogenous organic carbon source. However, how the protein profile changes to facilitate the cells differentially propagate in different modes has not been comprehensively investigated. Using isobaric labeling-based quantitative proteomics, we simultaneously identified and quantified 45% Synechocystis proteome across four different trophic modes, i.e., autotrophic, heterotrophic, photoheterotrophic, and mixotrophic modes. Among the 155 proteins that are differentially expressed across four trophic modes, proteins involved in nitrogen assimilation and light-independent chlorophyll synthesis are dramatically upregulated in the mixotrophic mode, concomitant with a dramatic increase of P II phosphorylation that senses carbon and nitrogen assimilation status. Moreover, functional study using a mutant defective in light-independent chlorophyll synthesis revealed that this pathway is important for chlorophyll accumulation under a cycled light/dark illumination regime, a condition mimicking day/night cycles in certain natural habitats. Collectively, these results provide the most comprehensive information on trophic mode-dependent protein expression in cyanobacterium, and reveal the functional significance of light-independent chlorophyll synthesis in trophic growth. Copyright © 2017 The Author. Published by Elsevier Inc. All rights reserved.

AlignMe—a membrane protein sequence alignment web server

PubMed Central

Stamm, Marcus; Staritzbichler, René; Khafizov, Kamil; Forrest, Lucy R.

2014-01-01

We present a web server for pair-wise alignment of membrane protein sequences, using the program AlignMe. The server makes available two operational modes of AlignMe: (i) sequence to sequence alignment, taking two sequences in fasta format as input, combining information about each sequence from multiple sources and producing a pair-wise alignment (PW mode); and (ii) alignment of two multiple sequence alignments to create family-averaged hydropathy profile alignments (HP mode). For the PW sequence alignment mode, four different optimized parameter sets are provided, each suited to pairs of sequences with a specific similarity level. These settings utilize different types of inputs: (position-specific) substitution matrices, secondary structure predictions and transmembrane propensities from transmembrane predictions or hydrophobicity scales. In the second (HP) mode, each input multiple sequence alignment is converted into a hydrophobicity profile averaged over the provided set of sequence homologs; the two profiles are then aligned. The HP mode enables qualitative comparison of transmembrane topologies (and therefore potentially of 3D folds) of two membrane proteins, which can be useful if the proteins have low sequence similarity. In summary, the AlignMe web server provides user-friendly access to a set of tools for analysis and comparison of membrane protein sequences. Access is available at http://www.bioinfo.mpg.de/AlignMe PMID:24753425

Multiple periodicities in the solar magnetic field - Possible origin in a multiple-mode solar dynamo

NASA Technical Reports Server (NTRS)

Boyer, D. W.; Levy, E. H.

1992-01-01

The solar magnetic field is generated in an oscillatory mode with a 22 yr full period and gives rise to the 11 yr sunspot cycle. However, analyses of contemporary solar records, as well as other surrogate indicators of solar activity, suggest the presence also of longer term periodicities in the solar magnetic cycle. This paper suggests that the solar dynamo can operate in a multiply periodic state, with several periodicites being generated simultaneously at different depths in the convection zone. A simple two-layer model of the solar convection zone is used to illustrate the physical mechanism of spatially localized, multiple-periodicity-mode dynamo regeneration. The two layers are characterized by differences in their respective turbulent magnetic diffusivities. Although the magnetic modes interact with one another, each mode is produced large in one layer or the other, and has an oscillation period approximately equal to the time characteristic of magnetic diffusion across the layer. The observed complicated periodicity pattern in the solar magnetic field could be a combination of two (or more) dynamo modes generated in this manner. The calculations are carried out using a differential rotation model consistent with recent helioseismological measurements, illustrating the challenge to dynamo theory raised by those observational results.

Mechanism of nonlinear flow pattern selection in moderately non-Boussinesq mixed convection.

PubMed

Suslov, Sergey A

2010-02-01

Nonlinear (non-Boussinesq) variations in fluid's density, viscosity, and thermal conductivity caused by a large temperature gradient in a flow domain lead to a wide variety of instability phenomena in mixed convection channel flow of a simple gas such as air. It is known that in strongly nonisothermal flows, the instabilities and the resulting flow patterns are caused by competing buoyancy and shear effects [see S. A. Suslov and S. Paolucci, J. Fluid Mech. 302, 91 (1995)]. However, as is the case in the Boussinesq limit of small temperature gradients, in moderately non-Boussinesq regimes, only a shear instability mechanism is active. Yet in contrast to Boussinesq flows, multiple instability modes are still detected. By reducing the system of full governing Navier-Stokes equations to a dynamical system of coupled Landau-type disturbance amplitude equations we compute a comprehensive parametric map of various shear-driven instabilities observed in a representative moderately non-Boussinesq regime. Subsequently, we analyze nonlinear interaction of unstable modes and reveal physical reasons for their appearance.

Weakly-coupled 4-mode step-index FMF and demonstration of IM/DD MDM transmission.

PubMed

Hu, Tao; Li, Juhao; Ge, Dawei; Wu, Zhongying; Tian, Yu; Shen, Lei; Liu, Yaping; Chen, Su; Li, Zhengbin; He, Yongqi; Chen, Zhangyuan

2018-04-02

Weakly coupled-mode division multiplexing (MDM) over few-mode fibers (FMF) for short-reach transmission has attracted great interest, which can avoid multiple-input-multiple-output digital signal processing (MIMO-DSP) by greatly suppressing modal crosstalk. In this paper, step-index FMF supporting 4 linearity polarization (LP) modes for MIMO-free transmission is designed and fabricated for the first time, to our knowledge. Modal crosstalk of the fiber is suppressed by increasing the mode effective refractive index differences. The same fabrication method as standard single-mode fiber is adopted so that it is practical and cost-effective. The mode multiplexer/demultiplexer (MUX/DEMUX) consists of cascaded mode-selective couplers (MSCs), which are designed and fabricated by tapering the proposed FMF with single-mode fiber (SMF). The mode MUX and DEMUX achieve very low modal crosstalk not only for the multiplexing/demultiplexing but also for the coupling to/from the FMF. Based on the fabricated FMF and mode MUX/DEMUX, we successfully demonstrate the first simultaneous 4-modes (LP 01 , LP 11 , LP 21 & LP 31 ) 10-km FMF transmission with 10-Gb/s intensity modulation and MIMO-free direct detection (IM/DD). The modal crosstalk of the whole transmission link is successfully suppressed to less than -16.5 dB. The experimental results indicate that FMF with simple step-index structure supporting 4 weakly-coupled modes is feasible.

Multi-mode radio frequency device

DOEpatents

Gilbert, Ronald W [Morgan Hill, CA; Carrender, Curtis Lee [Morgan Hill, CA; Anderson, Gordon A [Benton City, WA; Steele, Kerry D [Kennewick, WA

2007-02-13

A transponder device having multiple modes of operation, such as an active mode and a passive mode, wherein the modes of operation are selected in response to the strength of a received radio frequency signal. A communication system is also provided having a transceiver configured to transmit a radio frequency signal and to receive a responsive signal, and a transponder configured to operate in a plurality of modes and to activate modes of operation in response to the radio frequency signal. Ideally, each mode of operation is activated and deactivated independent of the other modes, although two or more modes may be concurrently operational.

How does a planet excite multiple spiral arms?

NASA Astrophysics Data System (ADS)

Bae, Jaehan; Zhu, Zhaohuan

2018-01-01

Protoplanetary disk simulations show that a single planet excites multiple spiral arms in the background disk, potentially supported by the multi-armed spirals revealed with recent high-resolution observations in some disks. The existence of multiple spiral arms is of importance in many aspects. It is empirically found that the arm-to-arm separation increases as a function of the planetary mass, so one can use the morphology of observed spiral arms to infer the mass of unseen planets. In addition, a spiral arm opens a radial gap as it steepens into a shock, so when a planet excites multiple spiral arms it can open multiple gaps in the disk. Despite the important implications, however, the formation mechanism of multiple spiral arms has not been fully understood by far.In this talk, we explain how a planet excites multiple spiral arms. The gravitational potential of a planet can be decomposed into a Fourier series, a sum of individual azimuthal modes having different azimuthal wavenumbers. Using a linear wave theory, we first demonstrate that appropriate sets of Fourier decomposed waves can be in phase, raising a possibility that constructive interference among the waves can produce coherent structures - spiral arms. More than one spiral arm can form since such constructive interference can occur at different positions in the disk for different sets of waves. We then verify this hypothesis using a suite of two-dimensional hydrodynamic simulations. Finally, we present non-linear behavior in the formation of multiple spiral arms.

Teaching Multiple Modes of Representation in Middle-School Science Classrooms: Impact on Student Learning and Multimodal Use

ERIC Educational Resources Information Center

Nixon, Ryan S.; Smith, Leigh K.; Wimmer, Jennifer J.

2015-01-01

This quasi-experimental study investigated how explicit instruction about multiple modes of representation (MMR) impacted grades 7 (n = 61) and 8 (n = 141) students' learning and multimodal use on end-of-unit assessments. Half of each teacher's (n = 3) students received an intervention consisting of explicit instruction on MMR in science…

Video-Enhanced Lesson Observation as a Source of Multiple Modes of Data for School Leadership: A Videographic Approach

ERIC Educational Resources Information Center

Hidson, Elizabeth

2018-01-01

A growing body of literature recognizes the affordances of video in education, especially in relation to lesson observation and reflection as part of teachers' initial teacher education and continuing professional development. Minimal attention has been paid to the outcomes of video-enhanced observation as a source of multiple modes of data for…

The pedagogical potential of drawing and writing in a primary science multimodal unit

NASA Astrophysics Data System (ADS)

Wilson, Rachel E.; Bradbury, Leslie U.

2016-11-01

In consideration of the potential of drawing and writing as assessment and learning tools, we explored how early primary students used these modes to communicate their science understandings. The context for this study was a curricular unit that incorporated multiple modes of representation in both the presentation of information and production of student understanding with a focus on the structure and function of carnivorous plants (CPs). Two science teacher educators and two first-grade teachers in the United States co-planned and co-taught a multimodal science unit on CP structure and function that included multiple representations of Venus flytraps (VFTs): physical specimens, photographs, videos, text, and discussions. Pre- and post-assessment student drawings and writings were statistically compared to note significant changes, and pre- and post-assessment writings were qualitatively analysed to note themes in student ideas. Results indicate that students increased their knowledge of VFT structure and function and synthesised information from multiple modes. While students included more structures of the VFT in their drawings, they were better able to describe the functions of structures in their writings. These results suggest the benefits for student learning and assessment of having early primary students represent their science understandings in multiple modes.

Multiple eigenmodes of the Rayleigh-Taylor instability observed for a fluid interface with smoothly varying density

NASA Astrophysics Data System (ADS)

Yu, C. X.; Xue, C.; Liu, J.; Hu, X. Y.; Liu, Y. Y.; Ye, W. H.; Wang, L. F.; Wu, J. F.; Fan, Z. F.

2018-01-01

In this article, multiple eigen-systems including linear growth rates and eigen-functions have been discovered for the Rayleigh-Taylor instability (RTI) by numerically solving the Sturm-Liouville eigen-value problem in the case of two-dimensional plane geometry. The system called the first mode has the maximal linear growth rate and is just extensively studied in literature. Higher modes have smaller eigen-values, but possess multi-peak eigen-functions which bring on multiple pairs of vortices in the vorticity field. A general fitting expression for the first four eigen-modes is presented. Direct numerical simulations show that high modes lead to appearances of multi-layered spike-bubble pairs, and lots of secondary spikes and bubbles are also generated due to the interactions between internal spikes and bubbles. The present work has potential applications in many research and engineering areas, e.g., in reducing the RTI growth during capsule implosions in inertial confinement fusion.

Multiple Functions of Endocannabinoid Signaling in the Brain

PubMed Central

Katona, István; Freund, Tamás F.

2014-01-01

Despite being regarded as a hippie science for decades, cannabinoid research has finally found its well-deserved position in mainstream neuroscience. A series of groundbreaking discoveries revealed that endocannabinoid molecules are as widespread and important as conventional neurotransmitters like glutamate or GABA, yet act in profoundly unconventional ways. We aim to illustrate how uncovering the molecular, anatomical and physiological characteristics of endocannabinoid signaling revealed new mechanistic insights into several fundamental phenomena in synaptic physiology. First, we summarize unexpected advances in the molecular complexity of biogenesis and inactivation of the two endocannabinoids, anandamide and 2-arachidonoylglycerol. Then we show how these new metabolic routes are integrated into well-known intracellular signaling pathways. These endocannabinoid-producing signalosomes operate in phasic and tonic modes thereby differentially governing homeostatic, short-term and long-term synaptic plasticity throughout the brain. Finally, we discuss how cell type- and synapse-specific refinement of endocannabinoid signaling may explain the characteristic behavioral effects of cannabinoids. PMID:22524785

Introduction to the Portable Life Support Schematic and Technology Development Components

NASA Technical Reports Server (NTRS)

Conger, Bruce

2008-01-01

Conger presented the operations and functions of the baseline Constellation Program (CxP) Portable Life Support System (PLSS) schematic and key development technologies. He explained the functional descriptions of the schematic components in the fluid systems of the PLSS for multiple operational scenarios. PLSS subsystems include the oxygen subsystem, the ventilation subsystem, and the thermal subsystem. He also presented the operational PLSS modes: Nominal EVA mode, Umbilical - no recharge mode, Umbilical - with recharge mode, BENDS mode, BUDDY mode, Secondary oxygen mode, and the PLSS-removed umbilical mode.

Portable multiplicity counter

DOEpatents

Newell, Matthew R [Los Alamos, NM; Jones, David Carl [Los Alamos, NM

2009-09-01

A portable multiplicity counter has signal input circuitry, processing circuitry and a user/computer interface disposed in a housing. The processing circuitry, which can comprise a microcontroller integrated circuit operably coupled to shift register circuitry implemented in a field programmable gate array, is configured to be operable via the user/computer interface to count input signal pluses receivable at said signal input circuitry and record time correlations thereof in a total counting mode, coincidence counting mode and/or a multiplicity counting mode. The user/computer interface can be for example an LCD display/keypad and/or a USB interface. The counter can include a battery pack for powering the counter and low/high voltage power supplies for biasing external detectors so that the counter can be configured as a hand-held device for counting neutron events.

Concept of a Fast and Simple Atmospheric Radiative Transfer Model for Aerosol Retrieval

NASA Astrophysics Data System (ADS)

Seidel, Felix; Kokhanovsky, Alexander A.

2010-05-01

Radiative transfer modelling (RTM) is an indispensable tool for a number of applications, including astrophysics, climate studies and quantitative remote sensing. It simulates the attenuation of light through a translucent medium. Here, we look at the scattering and absorption of solar light on its way to the Earth's surface and back to space or back into a remote sensing instrument. RTM is regularly used in the framework of the so-called atmospheric correction to find properties of the surface. Further, RTM can be inverted to retrieve features of the atmosphere, such as the aerosol optical depth (AOD), for instance. Present-day RTM, such as 6S, MODTRAN, SHARM, RT3, SCIATRAN or RTMOM have errors of only a few percent, however they are rather slow and often not easy to use. We present here a concept for a fast and simple RTM model in the visible spectral range. It is using a blend of different existing RTM approaches with a special emphasis on fast approximative analytical equations and parametrizations. This concept may be helpful for efficient retrieval algorithms, which do not have to rely on the classic look-up-tables (LUT) approach. For example, it can be used to retrieve AOD without complex inversion procedures including multiple iterations. Naturally, there is always a trade-off between speed and modelling accuracy. The code can be run therefore in two different modes. The regular mode provides a reasonable ratio between speed and accuracy, while the optional mode is very fast but less accurate. The normal mode approximates the diffuse scattered light by calculating the first (single scattering) and second order of scattering according to the classical method of successive orders of scattering. The very fast mode calculates only the single scattering approximation, which does not need any slow numerical integration procedure, and uses a simple correction factor to account for multiple scattering. This factor is a parametrization of MODTRAN results, which provide a typical ratio between single and multiple scattered light. A comparison of the presented RTM concept to the widely accepted 6S RTM reveals errors of up to 10% in standard mode. This is acceptable for certain applications. The very fast mode may lead to errors of up to 30%, but it is still able to reproduce qualitatively the results of 6S. An experimental implementation of this RTM concept is written in the common IDL language. It is therefore very flexible and straightforward to be implemented into custom retrieval algorithms of the remote sensing community. The code might also be used to add an atmosphere on top of an existing vegetation-canopy or water RTM. Due to the ease of use of the RTM code and the comprehensibility of the internal equations, the concept might be useful for educational purposes as well. The very fast mode could be of interest for a real-time applications, such as an in-flight instrument performance check for airborne optical sensors. In the future, the concept can be extended to account for scattering according to Mie theory, polarization and gaseous absorption. It is expected that this would reduce the model error to 5% or less.

Characterization of beam-driven instabilities and current redistribution in MST plasmas

NASA Astrophysics Data System (ADS)

Parke, E.

2015-11-01

A unique, high-rep-rate (>10 kHz) Thomson scattering diagnostic and a high-bandwidth FIR interferometer-polarimeter on MST have enabled characterization of beam-driven instabilities and magnetic equilibrium changes observed during high power (1 MW) neutral beam injection (NBI). While NBI leads to negligible net current drive, an increase in on-axis current density observed through Faraday rotation is offset by a reduction in mid-radius current. Identification of the phase flip in temperature fluctuations associated with tearing modes provides a sensitive measure of rational surface locations. This technique strongly constrains the safety factor for equilibrium reconstruction and provides a powerful new tool for measuring the equilibrium magnetic field. For example, the n = 6 temperature structure is observed to shift inward 1.1 +/- 0.6 cm, with an estimated reduction of q0 by 5%. This is consistent with a mid-radius reduction in current, and together the Faraday rotation and Thomson scattering measurements corroborate an inductive redistribution of current that compares well with TRANSP/MSTFit predictions. Interpreting tearing mode temperature structures in the RFP remains challenging; the effects of multiple, closely-spaced tearing modes on the mode phase measurement require further verification. In addition to equilibrium changes, previous work has shown that the large fast ion population drives instabilities at higher frequencies near the Alfvén continuum. Recent observations reveal a new instability at much lower frequency (~7 kHz) with strongly chirping behavior. It participates in extensive avalanches of the higher frequency energetic particle and Alfvénic modes to drive enhanced fast ion transport. Internal structures measured from Te and ne fluctuations, their dependence on the safety factor, as well as frequency scaling motivate speculation about mode identity. Work supported by U.S. DOE.

Emission-angle and polarization-rotation effects in the lensed CMB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Antony; Hall, Alex; Challinor, Anthony, E-mail: antony@cosmologist.info, E-mail: ahall@roe.ac.uk, E-mail: a.d.challinor@ast.cam.ac.uk

Lensing of the CMB is an important effect, and is usually modelled by remapping the unlensed CMB fields by a lensing deflection. However the lensing deflections also change the photon path so that the emission angle is no longer orthogonal to the background last-scattering surface. We give the first calculation of the emission-angle corrections to the standard lensing approximation from dipole (Doppler) sources for temperature and quadrupole sources for temperature and polarization. We show that while the corrections are negligible for the temperature and E-mode polarization, additional large-scale B-modes are produced with a white spectrum that dominates those from post-Bornmore » field rotation (curl lensing). On large scales about one percent of the total lensing-induced B-mode amplitude is expected to be due to this effect. However, the photon emission angle does remain orthogonal to the perturbed last-scattering surface due to time delay, and half of the large-scale emission-angle B modes cancel with B modes from time delay to give a total contribution of about half a percent. While not important for planned observations, the signal could ultimately limit the ability of delensing to reveal low amplitudes of primordial gravitational waves. We also derive the rotation of polarization due to multiple deflections between emission and observation. The rotation angle is of quadratic order in the deflection angle, and hence negligibly small: polarization typically rotates by less than an arcsecond, orders of magnitude less than a small-scale image rotates due to post-Born field rotation (which is quadratic in the shear). The field-rotation B modes dominate the other effects on small scales.« less

Mixed-Mode Surveys: A Strategy to Reduce Costs and Enhance Response Rates

ERIC Educational Resources Information Center

Tobin, Daniel; Thomson, Joan; Radhakrishna, Rama; LaBorde, Luke

2012-01-01

Mixed-mode surveys present one opportunity for Extension to determine program outcomes at lower costs. In order to conduct a follow-up evaluation, we implemented a mixed-mode survey that relied on communication using the Web, postal mailings, and telephone calls. Using multiple modes conserved costs by reducing the number of postal mailings yet…

Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling

NASA Astrophysics Data System (ADS)

Rosenfeld, Robin J.; Goodsell, David S.; Musah, Rabi A.; Morris, Garrett M.; Goodin, David B.; Olson, Arthur J.

2003-08-01

The W191G cavity of cytochrome c peroxidase is useful as a model system for introducing small molecule oxidation in an artificially created cavity. A set of small, cyclic, organic cations was previously shown to bind in the buried, solvent-filled pocket created by the W191G mutation. We docked these ligands and a set of non-binders in the W191G cavity using AutoDock 3.0. For the ligands, we compared docking predictions with experimentally determined binding energies and X-ray crystal structure complexes. For the ligands, predicted binding energies differed from measured values by ± 0.8 kcal/mol. For most ligands, the docking simulation clearly predicted a single binding mode that matched the crystallographic binding mode within 1.0 Å RMSD. For 2 ligands, where the docking procedure yielded an ambiguous result, solutions matching the crystallographic result could be obtained by including an additional crystallographically observed water molecule in the protein model. For the remaining 2 ligands, docking indicated multiple binding modes, consistent with the original electron density, suggesting disordered binding of these ligands. Visual inspection of the atomic affinity grid maps used in docking calculations revealed two patches of high affinity for hydrogen bond donating groups. Multiple solutions are predicted as these two sites compete for polar hydrogens in the ligand during the docking simulation. Ligands could be distinguished, to some extent, from non-binders using a combination of two trends: predicted binding energy and level of clustering. In summary, AutoDock 3.0 appears to be useful in predicting key structural and energetic features of ligand binding in the W191G cavity.

A vibrational spectroscopic study of tengerite-(Y) Y2(CO3)3 2-3H2O

NASA Astrophysics Data System (ADS)

Frost, Ray L.; López, Andrés; Wang, Lina; Scholz, Ricardo; Sampaio, Ney Pinheiro; de Oliveira, Fernando A. N.

2015-02-01

The mineral tengerite-(Y) has been studied by vibrational spectroscopy. Multiple carbonate stretching modes are observed and support the concept of non-equivalent carbonate units in the tengerite-(Y) structure. Intense sharp bands at 464, 479 and 508 cm-1 are assigned to YO stretching modes. Raman bands at 765 and 775 cm-1 are assigned to the CO32- ν4 bending modes and Raman bands at 589, 611, 674 and 689 cm-1 are assigned to the CO32- ν2 bending modes. Multiple Raman and infrared bands in the OH stretching region are observed, proving the existence of water in different molecular environments in the structure of tengerite-(Y).

On decentralized adaptive full-order sliding mode control of multiple UAVs.

PubMed

Xiang, Xianbo; Liu, Chao; Su, Housheng; Zhang, Qin

2017-11-01

In this study, a novel decentralized adaptive full-order sliding mode control framework is proposed for the robust synchronized formation motion of multiple unmanned aerial vehicles (UAVs) subject to system uncertainty. First, a full-order sliding mode surface in a decentralized manner is designed to incorporate both the individual position tracking error and the synchronized formation error while the UAV group is engaged in building a certain desired geometric pattern in three dimensional space. Second, a decentralized virtual plant controller is constructed which allows the embedded low-pass filter to attain the chattering free property of the sliding mode controller. In addition, robust adaptive technique is integrated in the decentralized chattering free sliding control design in order to handle unknown bounded uncertainties, without requirements for assuming a priori knowledge of bounds on the system uncertainties as stated in conventional chattering free control methods. Subsequently, system robustness as well as stability of the decentralized full-order sliding mode control of multiple UAVs is synthesized. Numerical simulation results illustrate the effectiveness of the proposed control framework to achieve robust 3D formation flight of the multi-UAV system. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Simultaneous Excitation of Multiple-Input Multiple-Output CFD-Based Unsteady Aerodynamic Systems

NASA Technical Reports Server (NTRS)

Silva, Walter A.

2008-01-01

A significant improvement to the development of CFD-based unsteady aerodynamic reduced-order models (ROMs) is presented. This improvement involves the simultaneous excitation of the structural modes of the CFD-based unsteady aerodynamic system that enables the computation of the unsteady aerodynamic state-space model using a single CFD execution, independent of the number of structural modes. Four different types of inputs are presented that can be used for the simultaneous excitation of the structural modes. Results are presented for a flexible, supersonic semi-span configuration using the CFL3Dv6.4 code.

Simultaneous Excitation of Multiple-Input Multiple-Output CFD-Based Unsteady Aerodynamic Systems

NASA Technical Reports Server (NTRS)

Silva, Walter A.

2007-01-01

A significant improvement to the development of CFD-based unsteady aerodynamic reduced-order models (ROMs) is presented. This improvement involves the simultaneous excitation of the structural modes of the CFD-based unsteady aerodynamic system that enables the computation of the unsteady aerodynamic state-space model using a single CFD execution, independent of the number of structural modes. Four different types of inputs are presented that can be used for the simultaneous excitation of the structural modes. Results are presented for a flexible, supersonic semi-span configuration using the CFL3Dv6.4 code.

An ultrahigh-performance liquid chromatography method with electrospray ionization tandem mass spectrometry for simultaneous quantification of five phytohormones in medicinal plant Glycyrrhiza uralensis under abscisic acid stress.

PubMed

Xiang, Yu; Song, Xiaona; Qiao, Jing; Zang, Yimei; Li, Yanpeng; Liu, Yong; Liu, Chunsheng

2015-07-01

An efficient simplified method was developed to determine multiple classes of phytohormones simultaneously in the medicinal plant Glycyrrhiza uralensis. Ultrahigh-performance liquid chromatography electrospray ionization tandem mass spectrometry (UPLC/ESI-MS/MS) with multiple reaction monitoring (MRM) in negative mode was used for quantification. The five studied phytohormones are gibberellic acid (GA3), abscisic acid (ABA), jasmonic acid (JA), indole-3-acetic acid, and salicylic acid (SA). Only 100 mg of fresh leaves was needed, with one purification step based on C18 solid-phase extraction. Cinnamic acid was chosen as the internal standard instead of isotope-labeled internal standards. Under the optimized conditions, the five phytohormones with internal standard were separated within 4 min, with good linearities and high sensitivity. The validated method was applied to monitor the spatial and temporal changes of the five phytohormones in G. uralensis under ABA stress. The levels of GA3, ABA, JA, and SA in leaves of G. uralensis were increased at different times and with different tendencies in the reported stress mode. These changes in phytohormone levels are discussed in the context of a possible feedback regulation mechanism. Understanding this mechanism will provide a good chance of revealing the mutual interplay between different biosynthetic routes, which could further help elucidate the mechanisms of effective composition accumulation in medicinal plants.

On the formation modes in vortex interaction for multiple co-axial co-rotating vortex rings

NASA Astrophysics Data System (ADS)

Qin, Suyang; Liu, Hong; Xiang, Yang

2018-01-01

Interaction among multiple vortices is of particular importance to biological locomotion. It plays an essential role in the force and energy capture. This study examines the motion and dynamics of multiple co-axial co-rotating vortex rings. The vortex rings, which have the same formation time, are successively generated in a piston-cylinder apparatus by accurately controlling the interval time. The flow fields are visualized by the finite-time Lyapunov exponent and then repelling Lagrangian coherent structures (r-LCSs) are determined. Two types of vortex interactions ("strong" and "weak") are defined by investigating the r-LCSs: a strong interaction is indicated by connected r-LCSs showing a channel for fluid transport (termed as a "flux window"); a weak interaction is indicated by disconnected r-LCSs between the vortex rings. For strong interaction, leapfrogging and merger of vortex rings can happen in the later stage of the evolution process; however, the rings are separated for weak interaction. Two distinct formation modes, the formation enhancement mode (FEM) and formation restraint mode (FRM), refer to the effect of one or multiple vortex ring(s) on the initial circulation of the subsequently formed vortex ring. In the FEM, the circulation of a vortex ring is larger than that of an isolated (without interaction) vortex ring. On the other hand, the situation is opposite in the FRM. A dimensionless number reflecting the interaction mechanism, "structure stretching number" S*, is proposed, which evaluates the induced effect of the wake vortices on the formation of a vortex ring. A limiting S* (SL*=(2 ±0.4 ) ×1 0-4) is the bifurcation point of the two formation modes. The augmentation of circulation reaches up to 10% for the FEM when S*SL*), the circulation decreases for at most 20%. The newly defined formation modes and number could shed light on the understanding of the dynamics of multiple vortex ring flows.

Orbital angular momentum mode groups multiplexing transmission over 2.6-km conventional multi-mode fiber.

PubMed

Zhu, Long; Wang, Andong; Chen, Shi; Liu, Jun; Mo, Qi; Du, Cheng; Wang, Jian

2017-10-16

Twisted light carrying orbital angular momentum (OAM) is a special kind of structured light that has a helical phase front, a phase singularity, and a doughnut intensity profile. Beyond widespread developments in manipulation, microscopy, metrology, astronomy, nonlinear and quantum optics, OAM-carrying twisted light has seen emerging application of optical communications in free space and specially designed fibers. Instead of specialty fibers, here we show the direct use of a conventional graded-index multi-mode fiber (MMF) for OAM communications. By exploiting fiber-compatible mode exciting and filtering elements, we excite the first four OAM mode groups in an MMF. We demonstrate 2.6-km MMF transmission using four data-carrying OAM mode groups (OAM 0,1 , OAM +1,1 /OAM -1,1 , OAM +2,1 , OAM +3,1 ). Moreover, we demonstrate two data-carrying OAM mode groups multiplexing transmission over the 2.6-km MMF with low-level crosstalk free of multiple-input multiple-output digital signal processing (MIMO-DSP). The demonstrations may open up new perspectives to fiber-based OAM communication/non-communication applications using already existing conventional fibers.

Multiplexed electronically programmable multimode ionization detector for chromatography

DOEpatents

Wise, M.B.; Buchanan, M.V.

1988-05-19

Method and apparatus for detecting and differentiating organic compounds based on their electron affinity. An electron capture detector cell (ECD) is operated in a plurality of multiplexed electronically programmable operating modes to alter the detector response during a single sampling cycle to acquire multiple simultaneous chromatograms corresponding to each of the different operating modes. The cell is held at a constant subatmospheric pressure while the electron collection bias voltage applied to the cell is modulated electronically to allow acquisition of multiple chromatograms for a single sample elution from a chromatograph representing three distinctly different response modes. A system is provided which automatically controls the programmed application of bias pulses at different intervals and/or amplitudes to switch the detector from an ionization mode to the electron capture mode and various degrees therebetween to provide an improved means of tuning an ECD for multimode detection and improved specificity. 6 figs.

Multiplexed electronically programmable multimode ionization detector for chromatography

DOEpatents

Wise, Marcus B.; Buchanan, Michelle V.

1989-01-01

Method and apparatus for detecting and differentiating organic compounds based on their electron affinity. An electron capture detector cell (ECD) is operated in a plurality of multiplexed electroncially programmable operating modes to alter the detector response during a single sampling cycle to acquire multiple simultaneous chromatograms corresponding to each of the different operating modes. The cell is held at a constant subatmospheric pressure while the electron collection bias voltage applied to the cell is modulated electronically to allow acquisition of multiple chromatograms for a single sample elution from a chromatograph representing three distinctly different response modes. A system is provided which automatically controls the programmed application of bias pulses at different intervals and/or amplitudes to switch the detector from an ionization mode to the electron capture mode and various degrees therebetween to provide an improved means of tuning an ECD for multimode detection and improved specificity.

Multiple time scale analysis of pressure oscillations in solid rocket motors

NASA Astrophysics Data System (ADS)

Ahmed, Waqas; Maqsood, Adnan; Riaz, Rizwan

2018-03-01

In this study, acoustic pressure oscillations for single and coupled longitudinal acoustic modes in Solid Rocket Motor (SRM) are investigated using Multiple Time Scales (MTS) method. Two independent time scales are introduced. The oscillations occur on fast time scale whereas the amplitude and phase changes on slow time scale. Hopf bifurcation is employed to investigate the properties of the solution. The supercritical bifurcation phenomenon is observed for linearly unstable system. The amplitude of the oscillations result from equal energy gain and loss rates of longitudinal acoustic modes. The effect of linear instability and frequency of longitudinal modes on amplitude and phase of oscillations are determined for both single and coupled modes. For both cases, the maximum amplitude of oscillations decreases with the frequency of acoustic mode and linear instability of SRM. The comparison of analytical MTS results and numerical simulations demonstrate an excellent agreement.

Black Hole Spectroscopy with Coherent Mode Stacking.

PubMed

Yang, Huan; Yagi, Kent; Blackman, Jonathan; Lehner, Luis; Paschalidis, Vasileios; Pretorius, Frans; Yunes, Nicolás

2017-04-21

The measurement of multiple ringdown modes in gravitational waves from binary black hole mergers will allow for testing the fundamental properties of black holes in general relativity and to constrain modified theories of gravity. To enhance the ability of Advanced LIGO/Virgo to perform such tasks, we propose a coherent mode stacking method to search for a chosen target mode within a collection of multiple merger events. We first rescale each signal so that the target mode in each of them has the same frequency and then sum the waveforms constructively. A crucial element to realize this coherent superposition is to make use of a priori information extracted from the inspiral-merger phase of each event. To illustrate the method, we perform a study with simulated events targeting the ℓ=m=3 ringdown mode of the remnant black holes. We show that this method can significantly boost the signal-to-noise ratio of the collective target mode compared to that of the single loudest event. Using current estimates of merger rates, we show that it is likely that advanced-era detectors can measure this collective ringdown mode with one year of coincident data gathered at design sensitivity.

Use of multiple modes of flight subsidy by a soaring terrestrial bird, the golden eagle Aquila chrysaetos, when on migration

PubMed Central

Katzner, Todd E.; Turk, Philip J.; Duerr, Adam E.; Miller, Tricia A.; Lanzone, Michael J.; Cooper, Jeff L.; Brandes, David; Tremblay, Junior A.; Lemaître, Jérôme

2015-01-01

Large birds regularly use updrafts to subsidize flight. Although most research on soaring bird flight has focused on use of thermal updrafts, there is evidence suggesting that many species are likely to use multiple modes of subsidy. We tested the degree to which a large soaring species uses multiple modes of subsidy to provide insights into the decision-making that underlies flight behaviour. We statistically classified more than 22 000 global positioning satellite–global system for mobile communications telemetry points collected at 30-s intervals to identify the type of subsidized flight used by 32 migrating golden eagles during spring in eastern North America. Eagles used subsidized flight on 87% of their journey. They spent 41.9% ± 1.5 (, range: 18–56%) of their subsidized northbound migration using thermal soaring, 45.2% ± 2.1 (12–65%) of time gliding between thermals, and 12.9% ± 2.2 (1–55%) of time using orographic updrafts. Golden eagles responded to the variable local-scale meteorological events they encountered by switching flight behaviour to take advantage of multiple modes of subsidy. Orographic soaring occurred more frequently in morning and evening, earlier in the migration season, and when crosswinds and tail winds were greatest. Switching between flight modes allowed migration for relatively longer periods each day and frequent switching behaviour has implications for a better understanding of avian flight behaviour and of the evolution of use of subsidy in flight. PMID:26538556

Single-Photon-Sensitive HgCdTe Avalanche Photodiode Detector

NASA Technical Reports Server (NTRS)

Huntington, Andrew

2013-01-01

The purpose of this program was to develop single-photon-sensitive short-wavelength infrared (SWIR) and mid-wavelength infrared (MWIR) avalanche photodiode (APD) receivers based on linear-mode HgCdTe APDs, for application by NASA in light detection and ranging (lidar) sensors. Linear-mode photon-counting APDs are desired for lidar because they have a shorter pixel dead time than Geiger APDs, and can detect sequential pulse returns from multiple objects that are closely spaced in range. Linear-mode APDs can also measure photon number, which Geiger APDs cannot, adding an extra dimension to lidar scene data for multi-photon returns. High-gain APDs with low multiplication noise are required for efficient linear-mode detection of single photons because of APD gain statistics -- a low-excess-noise APD will generate detectible current pulses from single photon input at a much higher rate of occurrence than will a noisy APD operated at the same average gain. MWIR and LWIR electron-avalanche HgCdTe APDs have been shown to operate in linear mode at high average avalanche gain (M > 1000) without excess multiplication noise (F = 1), and are therefore very good candidates for linear-mode photon counting. However, detectors fashioned from these narrow-bandgap alloys require aggressive cooling to control thermal dark current. Wider-bandgap SWIR HgCdTe APDs were investigated in this program as a strategy to reduce detector cooling requirements.

Optimal Time Allocation in Backscatter Assisted Wireless Powered Communication Networks.

PubMed

Lyu, Bin; Yang, Zhen; Gui, Guan; Sari, Hikmet

2017-06-01

This paper proposes a wireless powered communication network (WPCN) assisted by backscatter communication (BackCom). This model consists of a power station, an information receiver and multiple users that can work in either BackCom mode or harvest-then-transmit (HTT) mode. The time block is mainly divided into two parts corresponding to the data backscattering and transmission periods, respectively. The users first backscatter data to the information receiver in time division multiple access (TDMA) during the data backscattering period. When one user works in the BackCom mode, the other users harvest energy from the power station. During the data transmission period, two schemes, i.e., non-orthogonal multiple access (NOMA) and TDMA, are considered. To maximize the system throughput, the optimal time allocation policies are obtained. Simulation results demonstrate the superiority of the proposed model.

Optimal Time Allocation in Backscatter Assisted Wireless Powered Communication Networks

PubMed Central

Lyu, Bin; Yang, Zhen; Gui, Guan; Sari, Hikmet

2017-01-01

This paper proposes a wireless powered communication network (WPCN) assisted by backscatter communication (BackCom). This model consists of a power station, an information receiver and multiple users that can work in either BackCom mode or harvest-then-transmit (HTT) mode. The time block is mainly divided into two parts corresponding to the data backscattering and transmission periods, respectively. The users first backscatter data to the information receiver in time division multiple access (TDMA) during the data backscattering period. When one user works in the BackCom mode, the other users harvest energy from the power station. During the data transmission period, two schemes, i.e., non-orthogonal multiple access (NOMA) and TDMA, are considered. To maximize the system throughput, the optimal time allocation policies are obtained. Simulation results demonstrate the superiority of the proposed model. PMID:28587171

Multiple current peaks in room-temperature atmospheric pressure homogenous dielectric barrier discharge plasma excited by high-voltage tunable nanosecond pulse in air

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, De-Zheng; Wang, Wen-Chun; Zhang, Shuai

2013-05-13

Room temperature homogenous dielectric barrier discharge plasma with high instantaneous energy efficiency is acquired by using nanosecond pulse voltage with 20-200 ns tunable pulse width. Increasing the voltage pulse width can lead to the generation of regular and stable multiple current peaks in each discharge sequence. When the voltage pulse width is 200 ns, more than 5 organized current peaks can be observed under 26 kV peak voltage. Investigation also shows that the organized multiple current peaks only appear in homogenous discharge mode. When the discharge is filament mode, organized multiple current peaks are replaced by chaotic filament current peaks.

Three-dimensional flows in a hyperelastic vessel under external pressure.

PubMed

Zhang, Sen; Luo, Xiaoyu; Cai, Zongxi

2018-05-09

We study the collapsible behaviour of a vessel conveying viscous flows subject to external pressure, a scenario that could occur in many physiological applications. The vessel is modelled as a three-dimensional cylindrical tube of nonlinear hyperelastic material. To solve the fully coupled fluid-structure interaction, we have developed a novel approach based on the Arbitrary Lagrangian-Eulerian (ALE) method and the frontal solver. The method of rotating spines is used to enable an automatic mesh adaptation. The numerical code is verified extensively with published results and those obtained using the commercial packages in simpler cases, e.g. ANSYS for the structure with the prescribed flow, and FLUENT for the fluid flow with prescribed structure deformation. We examine three different hyperelastic material models for the tube for the first time in this context and show that at the small strain, all three material models give similar results. However, for the large strain, results differ depending on the material model used. We further study the behaviour of the tube under a mode-3 buckling and reveal its complex flow patterns under various external pressures. To understand these flow patterns, we show how energy dissipation is associated with the boundary layers created at the narrowest collapsed section of the tube, and how the transverse flow forms a virtual sink to feed a strong axial jet. We found that the energy dissipation associated with the recirculation does not coincide with the flow separation zone itself, but overlaps with the streamlines that divide the three recirculation zones. Finally, we examine the bifurcation diagrams for both mode-3 and mode-2 collapses and reveal that multiple solutions exist for a range of the Reynolds number. Our work is a step towards modelling more realistic physiological flows in collapsible arteries and veins.

System and process for pulsed multiple reaction monitoring

DOEpatents

Belov, Mikhail E

2013-05-17

A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.

Tunable and switchable dual-wavelength dissipative soliton generation in an all-normal-dispersion Yb-doped fiber laser with birefringence fiber filter.

PubMed

Zhang, Z X; Xu, Z W; Zhang, L

2012-11-19

We report the generation of tunable single- and dual-wavelength dissipative solitons in an all-normal-dispersion mode-locked Yb-doped fiber laser, to the best of our knowledge, for the first time. Besides single-wavelength mode-locking, dual-wavelength mode-locking was achieved using an in-line birefringence fiber filter with periodic multiple passbands, which not only allows multiple wavelengths to oscillate simultaneously but also performs spectrum modulation on highly chirped dissipative pulse. Furthermore, taking advantage of the tunability of the birefringence fiber filter, wavelength tuning for both single- and dual-wavelength dissipative soliton mode-locking was realized. The dual-wavelength operation is also switchable. The all-fiber dissipative laser with flexible outputs can meet diverse application needs.

Low-bending loss and single-mode operation in few-mode optical fiber

NASA Astrophysics Data System (ADS)

Yin, Ping; Wang, Hua; Chen, Ming-Yang; Wei, Jin; Cai, Zhi-Min; Li, Lu-Ming; Yang, Ji-Hai; Zhu, Yuan-Feng

2016-10-01

The technique of eliminating the higher-order modes in a few-mode optical fiber is proposed. The fiber is designed with a group of defect modes in the cladding. The higher-order modes in the fiber can be eliminated by bending the fiber to induce strong coupling between the defect modes and the higher-order modes. Numerical simulation shows the bending losses of the LP01 mode are lower than 1.5×10-4 dB/turn for the wavelength shorter than 1.625 μm. The proposed fiber can be bent multiple turns at small bending radius which are preferable for FTTH related applications.

Multiple Modes of Inquiry in Earth Science

ERIC Educational Resources Information Center

Kastens, Kim A.; Rivet, Ann

2008-01-01

To help teachers enrich their students' understanding of inquiry in Earth science, this article describes six modes of inquiry used by practicing geoscientists (Earth scientists). Each mode of inquiry is illustrated by using examples of seminal or pioneering research and provides pointers to investigations that enable students to experience these…

Picosecond x-ray strain rosette reveals direct laser excitation of coherent transverse acoustic phonons

PubMed Central

Lee, Sooheyong; Williams, G. Jackson; Campana, Maria I.; Walko, Donald A.; Landahl, Eric C.

2016-01-01

Using a strain-rosette, we demonstrate the existence of transverse strain using time-resolved x-ray diffraction from multiple Bragg reflections in laser-excited bulk gallium arsenide. We find that anisotropic strain is responsible for a considerable fraction of the total lattice motion at early times before thermal equilibrium is achieved. Our measurements are described by a new model where the Poisson ratio drives transverse motion, resulting in the creation of shear waves without the need for an indirect process such as mode conversion at an interface. Using the same excitation geometry with the narrow-gap semiconductor indium antimonide, we detected coherent transverse acoustic oscillations at frequencies of several GHz. PMID:26751616

Influences of operational parameters on phosphorus removal in batch and continuous electrocoagulation process performance.

PubMed

Nguyen, Dinh Duc; Yoon, Yong Soo; Bui, Xuan Thanh; Kim, Sung Su; Chang, Soon Woong; Guo, Wenshan; Ngo, Huu Hao

2017-11-01

Performance of an electrocoagulation (EC) process in batch and continuous operating modes was thoroughly investigated and evaluated for enhancing wastewater phosphorus removal under various operating conditions, individually or combined with initial phosphorus concentration, wastewater conductivity, current density, and electrolysis times. The results revealed excellent phosphorus removal (72.7-100%) for both processes within 3-6 min of electrolysis, with relatively low energy requirements, i.e., less than 0.5 kWh/m 3 for treated wastewater. However, the removal efficiency of phosphorus in the continuous EC operation mode was better than that in batch mode within the scope of the study. Additionally, the rate and efficiency of phosphorus removal strongly depended on operational parameters, including wastewater conductivity, initial phosphorus concentration, current density, and electrolysis time. Based on experimental data, statistical model verification of the response surface methodology (RSM) (multiple factor optimization) was also established to provide further insights and accurately describe the interactive relationship between the process variables, thus optimizing the EC process performance. The EC process using iron electrodes is promising for improving wastewater phosphorus removal efficiency, and RSM can be a sustainable tool for predicting the performance of the EC process and explaining the influence of the process variables.

Ion and neutral dynamics in Hall plasma accelerator ionization instabilities

NASA Astrophysics Data System (ADS)

Lucca Fabris, Andrea; Young, Christopher; Cappelli, Mark

2015-09-01

Hall thrusters, the extensively studied E × B devices used for space propulsion applications, are rife with instabilities and fluctuations. Many are thought to be fundamentally linked to microscopic processes like electron transport across magnetic field lines and propellant ionization that in turn affect macroscopic properties like device performance and lifetime. One of the strongest oscillatory regimes is the ``breathing mode,'' characterized by a propagating ionization front, time-varying ion acceleration profiles, and quasi-periodic 10-50 kHz current oscillations. Determining the temporal and spatial evolution of plasma properties is critical to achieving a fundamental physical understanding of these processes. We present non-intrusive laser-induced fluorescence measurements of the local ion and neutral velocity distribution functions synchronized with the breathing mode oscillations. Measurements reveal strong ion velocity fluctuations, multiple ion populations arising in narrow time windows throughout the near-field plume, and the periodic population and depopulation of neutral excited states. Analyzing these detailed experimental results in the context of the existing literature clarifies the fundamental physical processes underlying the breathing mode. This work is sponsored by the U.S. Air Force Office of Scientific Research with Dr. M. Birkan as program manager. C.Y. acknowledges support from the DOE NSSA Stewardship Science Graduate Fellowship under contract DE-FC52-08NA28752.

Insights into the mode of action of anticandidal herbal monoterpenoid geraniol reveal disruption of multiple MDR mechanisms and virulence attributes in Candida albicans.

PubMed

Singh, Shweta; Fatima, Zeeshan; Hameed, Saif

2016-07-01

The anticandidal potential of Geraniol (Ger) against Candida albicans has already been established. The present study reveals deeper insights into the mechanisms of action of Ger. We observed that the repertoire of antifungal activity was not only limited to C. albicans and its clinical isolates but also against non-albicans species of Candida. The membrane tampering effect was visualized through transmission electron micrographs, depleted ergosterol levels and altered plasma membrane ATPase activity. Ger also affects cell wall as revealed by spot assays with cell wall-perturbing agents and scanning electron micrographs. Functional calcineurin pathway seems to be indispensable for the antifungal effect of Ger as calcineurin signaling mutant was hypersensitive to Ger while calcineurin overexpressing strain remained resistant. Ger also causes mitochondrial dysfunction, impaired iron homeostasis and genotoxicity. Furthermore, Ger inhibits both virulence attributes of hyphal morphogenesis and biofilm formation. Taken together, our results suggest that Ger is potential antifungal agent that warrants further investigation in clinical applications so that it could be competently employed in therapeutic strategies to treat Candida infections.

Brain system for mental orientation in space, time, and person

PubMed Central

Peer, Michael; Salomon, Roy; Goldberg, Ilan; Blanke, Olaf; Arzy, Shahar

2015-01-01

Orientation is a fundamental mental function that processes the relations between the behaving self to space (places), time (events), and person (people). Behavioral and neuroimaging studies have hinted at interrelations between processing of these three domains. To unravel the neurocognitive basis of orientation, we used high-resolution 7T functional MRI as 16 subjects compared their subjective distance to different places, events, or people. Analysis at the individual-subject level revealed cortical activation related to orientation in space, time, and person in a precisely localized set of structures in the precuneus, inferior parietal, and medial frontal cortex. Comparison of orientation domains revealed a consistent order of cortical activity inside the precuneus and inferior parietal lobes, with space orientation activating posterior regions, followed anteriorly by person and then time. Core regions at the precuneus and inferior parietal lobe were activated for multiple orientation domains, suggesting also common processing for orientation across domains. The medial prefrontal cortex showed a posterior activation for time and anterior for person. Finally, the default-mode network, identified in a separate resting-state scan, was active for all orientation domains and overlapped mostly with person-orientation regions. These findings suggest that mental orientation in space, time, and person is managed by a specific brain system with a highly ordered internal organization, closely related to the default-mode network. PMID:26283353

Multi-species detection using multi-mode absorption spectroscopy (MUMAS)

NASA Astrophysics Data System (ADS)

Northern, J. H.; Thompson, A. W. J.; Hamilton, M. L.; Ewart, P.

2013-06-01

The detection of multiple species using a single laser and single detector employing multi-mode absorption spectroscopy (MUMAS) is reported. An in-house constructed, diode-pumped, Er:Yb:glass micro-laser operating at 1,565 nm with 10 modes separated by 18 GHz was used to record MUMAS signals in a gas mixture containing C2H2, N2O and CO. The components of the mixture were detected simultaneously by identifying multiple transitions in each of the species. By using temperature- and pressure-dependent modelled spectral fits to the data, partial pressures of each species in the mixture were determined with an uncertainty of ±2 %.

An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wong, Jaslyn E. M. M.; Midtgaard, Søren Roi; Gysel, Kira

The crystal and solution structures of the T. thermophilus NlpC/P60 d, l-endopeptidase as well as the co-crystal structure of its N-terminal LysM domains bound to chitohexaose allow a proposal to be made regarding how the enzyme recognizes peptidoglycan. LysM domains, which are frequently present as repetitive entities in both bacterial and plant proteins, are known to interact with carbohydrates containing N-acetylglucosamine (GlcNAc) moieties, such as chitin and peptidoglycan. In bacteria, the functional significance of the involvement of multiple LysM domains in substrate binding has so far lacked support from high-resolution structures of ligand-bound complexes. Here, a structural study of themore » Thermus thermophilus NlpC/P60 endopeptidase containing two LysM domains is presented. The crystal structure and small-angle X-ray scattering solution studies of this endopeptidase revealed the presence of a homodimer. The structure of the two LysM domains co-crystallized with N-acetyl-chitohexaose revealed a new intermolecular binding mode that may explain the differential interaction between LysM domains and short or long chitin oligomers. By combining the structural information with the three-dimensional model of peptidoglycan, a model suggesting how protein dimerization enhances the recognition of peptidoglycan is proposed.« less

[Effects of birth order, maternal abortion and mode of delivery on childhood acute leukemia risk: a meta-analysis].

PubMed

Zou, Guobin; Sha, Xia

2014-03-01

To evaluate the associations between birth order, maternal abortion and mode of delivery and childhood acute leukemia risk. Multiple electronic databases were searched to identify relevant studies up to March 2013 using the search terms "childhood leukemia", "acute lymphoblastic leukemia", "acute myeloid leukemia","birth order", "abortion", "miscarriage", "cesarean", "birth characteristics" and "prenatal risk factor". Data from cohort and case-control studies were analyzed using the Stata software. Twenty-three studies were included in this meta-analysis according to the selection criteria. No significant associations were identified for birth order and mode of delivery (birth order = 2: OR = 0.97, 95%CI: 0.89-1.05; birth order = 3: OR = 1.00, 95%CI: 0.91-1.11; birth order ≥ 4: OR = 1.02, 95%CI: 0.87-1.20; mode of delivery: OR = 1.05, 95%CI: 0.96-1.15). However, there was a significant association between maternal abortion and childhood acute leukemia risk (spontaneous abortion: OR = 1.21, 95%CI: 1.05-1.41; induced abortion: OR = 1.23, 95%CI: 1.07-1.43). Furthermore, the stratified analysis by disease subtypes showed that spontaneous and induced abortions were significantly associated with the risks of childhood acute myeloid leukemia (OR = 1.71, 95%CI: 1.09-2.70) and acute lymphoblastic leukemia (OR = 1.23, 95%CI: 1.05-1.42), respectively. This meta-analysis revealed that maternal abortion might contribute to the childhood acute leukemia risk.

Investigating vibrational relaxation in cyanide-bridged transition metal mixed-valence complexes using two-dimensional infrared and infrared pump-probe spectroscopies

PubMed Central

Slenkamp, Karla M.; Lynch, Michael S.; Brookes, Jennifer F.; Bannan, Caitlin C.; Daifuku, Stephanie L.; Khalil, Munira

2016-01-01

Using polarization-selective two-dimensional infrared (2D IR) and infrared pump-probe spectroscopies, we study vibrational relaxation of the four cyanide stretching (νCN) vibrations found in [(NH3)5RuIIINCFeII(CN)5]− (FeRu) dissolved in D2O or formamide and [(NC)5FeIICNPtIV(NH3)4NCFeII(CN)5]4− (FePtFe) dissolved in D2O. These cyanide-bridged transition metal complexes serve as models for understanding the role high frequency vibrational modes play in metal-to-metal charge transfers over a bridging ligand. However, there is currently little information about vibrational relaxation and dephasing dynamics of the anharmonically coupled νCN modes in the electronic ground state of these complexes. IR pump-probe experiments reveal that the vibrational lifetimes of the νCN modes are ∼2 times faster when FeRu is dissolved in D2O versus formamide. They also reveal that the vibrational lifetimes of the νCN modes of FePtFe in D2O are almost four times as long as for FeRu in D2O. Combined with mode-specific relaxation dynamics measured from the 2D IR experiments, the IR pump-probe experiments also reveal that intramolecular vibrational relaxation is occurring in all three systems on ∼1 ps timescale. Center line slope dynamics, which have been shown to be a measure of the frequency-frequency correlation function, reveal that the radial, axial, and trans νCN modes exhibit a ∼3 ps timescale for frequency fluctuations. This timescale is attributed to the forming and breaking of hydrogen bonds between each mode and the solvent. The results presented here along with our previous work on FeRu and FePtFe reveal a picture of coupled anharmonic νCN modes where the spectral diffusion and vibrational relaxation dynamics depend on the spatial localization of the mode on the molecular complex and its specific interaction with the solvent. PMID:27158634

Investigating vibrational relaxation in cyanide-bridged transition metal mixed-valence complexes using two-dimensional infrared and infrared pump-probe spectroscopies.

PubMed

Slenkamp, Karla M; Lynch, Michael S; Brookes, Jennifer F; Bannan, Caitlin C; Daifuku, Stephanie L; Khalil, Munira

2016-03-01

Using polarization-selective two-dimensional infrared (2D IR) and infrared pump-probe spectroscopies, we study vibrational relaxation of the four cyanide stretching (νCN) vibrations found in [(NH3)5Ru(III)NCFe(II)(CN)5](-) (FeRu) dissolved in D2O or formamide and [(NC)5Fe(II)CNPt(IV)(NH3)4NCFe(II)(CN)5](4-) (FePtFe) dissolved in D2O. These cyanide-bridged transition metal complexes serve as models for understanding the role high frequency vibrational modes play in metal-to-metal charge transfers over a bridging ligand. However, there is currently little information about vibrational relaxation and dephasing dynamics of the anharmonically coupled νCN modes in the electronic ground state of these complexes. IR pump-probe experiments reveal that the vibrational lifetimes of the νCN modes are ∼2 times faster when FeRu is dissolved in D2O versus formamide. They also reveal that the vibrational lifetimes of the νCN modes of FePtFe in D2O are almost four times as long as for FeRu in D2O. Combined with mode-specific relaxation dynamics measured from the 2D IR experiments, the IR pump-probe experiments also reveal that intramolecular vibrational relaxation is occurring in all three systems on ∼1 ps timescale. Center line slope dynamics, which have been shown to be a measure of the frequency-frequency correlation function, reveal that the radial, axial, and trans νCN modes exhibit a ∼3 ps timescale for frequency fluctuations. This timescale is attributed to the forming and breaking of hydrogen bonds between each mode and the solvent. The results presented here along with our previous work on FeRu and FePtFe reveal a picture of coupled anharmonic νCN modes where the spectral diffusion and vibrational relaxation dynamics depend on the spatial localization of the mode on the molecular complex and its specific interaction with the solvent.

Tunable orbital angular momentum mode filter based on optical geometric transformation.

PubMed

Huang, Hao; Ren, Yongxiong; Xie, Guodong; Yan, Yan; Yue, Yang; Ahmed, Nisar; Lavery, Martin P J; Padgett, Miles J; Dolinar, Sam; Tur, Moshe; Willner, Alan E

2014-03-15

We present a tunable mode filter for spatially multiplexed laser beams carrying orbital angular momentum (OAM). The filter comprises an optical geometric transformation-based OAM mode sorter and a spatial light modulator (SLM). The programmable SLM can selectively control the passing/blocking of each input OAM beam. We experimentally demonstrate tunable filtering of one or multiple OAM modes from four multiplexed input OAM modes with vortex charge of ℓ=-9, -4, +4, and +9. The measured output power suppression ratio of the propagated modes to the blocked modes exceeds 14.5 dB.

Cos-Gaussian modal field of a terahertz rectangular metal waveguide filled with multiple slices of dielectric

NASA Astrophysics Data System (ADS)

Wang, Kai; Cao, Qing; Zhang, Huifang; Shen, Pengcheng; Xing, Lujing

2018-06-01

Based on the TE01 mode of a rectangular metal waveguide and the Gaussian mode of a fiber, we propose the cos-Gaussian mode of a terahertz rectangular metal waveguide filled with multiple slices of dielectric. First, we consider a rectangular metal waveguide filled with an ideal graded-index dielectric along one direction. Furthermore, we replace the graded-index dielectric with multiple slices of dielectric according to the effective medium theory. The modal field, the effective index, and the coupling efficiency of this waveguide are investigated. It is found that the approximately linearly polarized electric field is Gaussian along one dimensionality and cosine along the other one. In addition, the low loss and high coupling efficiency with a Gaussian beam can be acquired at 0.9 THz. By optimization, the coupling efficiency could reach 88.5%.

Discrimination of orbital angular momentum modes of the terahertz vortex beam using a diffractive mode transformer.

PubMed

Liu, Changming; Wei, Xuli; Niu, Liting; Wang, Kejia; Yang, Zhengang; Liu, Jinsong

2016-06-13

We present an efficient method to discriminate orbital angular momentum (OAM) of the terahertz (THz) vortex beam using a diffractive mode transformer. The mode transformer performs a log-polar coordinate transformation of the input THz vortex beam, which consists of two 3D-printed diffractive elements. A following lens separates each transformed OAM mode to a different lateral position in its focal plane. This method enables a simultaneous measurement over multiple OAM modes of the THz vortex beam. We experimentally demonstrate the measurement of seven individual OAM modes and two multiplexed OAM modes, which is in good agreement with simulations.

Three-mode mode-division-multiplexing passive optical network over 12-km low mode-crosstalk FMF using all-fiber mode MUX/DEMUX

NASA Astrophysics Data System (ADS)

Ren, Fang; Li, Juhao; Wu, Zhongying; Hu, Tao; Yu, Jinyi; Mo, Qi; He, Yongqi; Chen, Zhangyuan; Li, Zhengbin

2017-01-01

We propose three-mode mode-division-multiplexing passive optical network (MDM-PON) based on low mode-crosstalk few-mode fiber (FMF) and all-fiber mode multiplexer/demultiplexer (MUX/DEMUX). The FMF with step-index profile is designed and fabricated for effectively three-independent-spatial-mode transmission and low mode-crosstalk for MDM-PON transmission. The all-fiber mode MUX/DEMUX are composed of cascaded mode selective couplers (MSCs), which simultaneously multiplex or demultiplex multiple modes. Based on the low mode-crosstalk of the FMF and all-fiber mode MUX/DEMUX, each optical network unit (ONU) communicates with the optical line terminal (OLT) independently utilizing a different optical linearly polarized (LP) spatial mode in MDM-PON system. We experimentally demonstrate MDM-PON transmission of three independent-spatial-modes over 12-km FMF with 10-Gb/s optical on-off keying (OOK) signal and direct detection.

Dual-color single-mode lasing in axially coupled organic nanowire resonators

PubMed Central

Zhang, Chunhuan; Zou, Chang-Ling; Dong, Haiyun; Yan, Yongli; Yao, Jiannian; Zhao, Yong Sheng

2017-01-01

Miniaturized lasers with multicolor output and high spectral purity are of crucial importance for yielding more compact and more versatile photonic devices. However, multicolor lasers usually operate in multimode, which largely restricts their practical applications due to the lack of an effective mode selection mechanism that is simultaneously applicable to multiple wavebands. We propose a mutual mode selection strategy to realize dual-color single-mode lasing in axially coupled cavities constructed from two distinct organic self-assembled single-crystal nanowires. The unique mode selection mechanism in the heterogeneously coupled nanowires was elucidated experimentally and theoretically. With each individual nanowire functioning as both the laser source and the mode filter for the other nanowire, dual-color single-mode lasing was successfully achieved in the axially coupled heterogeneous nanowire resonators. Furthermore, the heterogeneously coupled resonators provided multiple nanoscale output ports for delivering coherent signals with different colors, which could greatly contribute to increasing the integration level of functional photonic devices. These results advance the fundamental understanding of the lasing modulation in coupled cavity systems and offer a promising route to building multifunctional nanoscale lasers for high-level practical photonic integrations. PMID:28785731

Reduced rank models for travel time estimation of low order mode pulses.

PubMed

Chandrayadula, Tarun K; Wage, Kathleen E; Worcester, Peter F; Dzieciuch, Matthew A; Mercer, James A; Andrew, Rex K; Howe, Bruce M

2013-10-01

Mode travel time estimation in the presence of internal waves (IWs) is a challenging problem. IWs perturb the sound speed, which results in travel time wander and mode scattering. A standard approach to travel time estimation is to pulse compress the broadband signal, pick the peak of the compressed time series, and average the peak time over multiple receptions to reduce variance. The peak-picking approach implicitly assumes there is a single strong arrival and does not perform well when there are multiple arrivals due to scattering. This article presents a statistical model for the scattered mode arrivals and uses the model to design improved travel time estimators. The model is based on an Empirical Orthogonal Function (EOF) analysis of the mode time series. Range-dependent simulations and data from the Long-range Ocean Acoustic Propagation Experiment (LOAPEX) indicate that the modes are represented by a small number of EOFs. The reduced-rank EOF model is used to construct a travel time estimator based on the Matched Subspace Detector (MSD). Analysis of simulation and experimental data show that the MSDs are more robust to IW scattering than peak picking. The simulation analysis also highlights how IWs affect the mode excitation by the source.

Burst Mode Composite Photography for Dynamic Physics Demonstrations

ERIC Educational Resources Information Center

Lincoln, James

2018-01-01

I am writing this article to raise awareness of burst mode photography as a fun and engaging way for teachers and students to experience physics demonstration activities. In the context of digital photography, "burst mode" means taking multiple photographs per second, and this is a feature that now comes standard on most digital…

75 FR 77569 - Special Conditions: Gulfstream Model GVI Airplane; Electronic Flight Control System Mode...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-13

... Unusual Design Features The GVI will have a fly-by-wire electronic flight control system. This system... the design of the flight control system has multiple modes of operation, a means must be provided to... Control System Mode Annunciation AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...

Bicoherence Analysis of Electrostatic Interchange Mode Coupling in a Turbulent Laboratory Magnetosphere

NASA Astrophysics Data System (ADS)

Abler, M. C.; Saperstein, A.; Yan, J. R.; Mauel, M. E.

2017-10-01

Plasmas confined by a strong dipole field exhibit interchange and entropy mode turbulence, which previous experiments have shown respond locally to active feedback. On the Collisionless Terrella Experiment (CTX), this turbulence is characterized by low frequency, low order, quasi-coherent modes with complex spectral dynamics. We apply bicoherence analysis to study nonlinear phase coupling in a variety of scenarios. First, we study the self-interaction of the naturally occurring interchange turbulence; this analysis is then expanded to include the effects of driven modes in the frequency range of the background turbulent oscillations. Initial measurements of coupling coefficients are presented in both cases. Driven low frequency interchange modes are observed to generate multiple harmonics which persist throughout the plasma, becoming weaker as they propagate away from the actuator in the direction of the electron magnetic drift. Future work is also discussed, including application of wavelet bicoherence analysis, excitation of interchange modes at multiple frequencies, and applications to planetary magnetospheres. Supported by NSF-DOE Partnership for Plasma Science Grants DOE-DE-FG02-00ER54585.

Orbital-angular-momentum mode-group multiplexed transmission over a graded-index ring-core fiber based on receive diversity and maximal ratio combining

NASA Astrophysics Data System (ADS)

Zhang, Junwei; Zhu, Guoxuan; Liu, Jie; Wu, Xiong; Zhu, Jiangbo; Du, Cheng; Luo, Wenyong; Chen, Yujie; Yu, Siyuan

2018-02-01

An orbital-angular-momentum (OAM) mode-group multiplexing (MGM) scheme based on a graded-index ring-core fiber (GIRCF) is proposed, in which a single-input two-output (or receive diversity) architecture is designed for each MG channel and simple digital signal processing (DSP) is utilized to adaptively resist the mode partition noise resulting from random intra-group mode crosstalk. There is no need of complex multiple-input multiple-output (MIMO) equalization in this scheme. Furthermore, the signal-to-noise ratio (SNR) of the received signals can be improved if a simple maximal ratio combining (MRC) technique is employed on the receiver side to efficiently take advantage of the diversity gain of receiver. Intensity-modulated direct-detection (IM-DD) systems transmitting three OAM mode groups with total 100-Gb/s discrete multi-tone (DMT) signals over a 1-km GIRCF and two OAM mode groups with total 40-Gb/s DMT signals over an 18-km GIRCF are experimentally demonstrated, respectively, to confirm the feasibility of our proposed OAM-MGM scheme.

Ultrasonic Imaging in Solids Using Wave Mode Beamforming.

PubMed

di Scalea, Francesco Lanza; Sternini, Simone; Nguyen, Thompson Vu

2017-03-01

This paper discusses some improvements to ultrasonic synthetic imaging in solids with primary applications to nondestructive testing of materials and structures. Specifically, the study proposes new adaptive weights applied to the beamforming array that are based on the physics of the propagating waves, specifically the displacement structure of the propagating longitudinal (L) mode and shear (S) mode that are naturally coexisting in a solid. The wave mode structures can be combined with the wave geometrical spreading to better filter the array (in a matched filter approach) and improve its focusing ability compared to static array weights. This paper also proposes compounding, or summing, images obtained from the different wave modes to further improve the array gain without increasing its physical aperture. The wave mode compounding can be performed either incoherently or coherently, in analogy with compounding multiple frequencies or multiple excitations. Numerical simulations and experimental testing demonstrate the potential improvements obtainable by the wave structure adaptive weights compared to either static weights in conventional delay-and-sum focusing, or adaptive weights based on geometrical spreading alone in minimum-variance distortionless response focusing.

Mode identification from spectroscopy of gravity-mode pulsators

NASA Astrophysics Data System (ADS)

Pollard, K. R.; Brunsden, E.; Cottrell, P. L.; Davie, M.; Greenwood, A.; Wright, D. J.; De Cat, P.

2014-02-01

The gravity modes present in γ Doradus stars probe the deep stellar interiors and are thus of particular interest in asteroseismology. For the MUSICIAN programme at the University of Canterbury, we obtain extensive high-resolution echelle spectra of γ Dor stars from the Mt John University Observatory in New Zealand. We analyze these to obtain the pulsational frequencies and identify these with the multiple pulsational modes excited in the star. A summary of recent results from our spectroscopic mode-identification programme is given.

Ultra-Thin Multi-Band Polarization-Insensitive Microwave Metamaterial Absorber Based on Multiple-Order Responses Using a Single Resonator Structure

PubMed Central

Cheng, Zheng Ze; Mao, Xue Song; Gong, Rong Zhou

2017-01-01

We design an ultra-thin multi-band polarization-insensitive metamaterial absorber (MMA) using a single circular sector resonator (CSR) structure in the microwave region. Simulated results show that the proposed MMA has three distinctive absorption peaks at 3.35 GHz, 8.65 GHz, and 12.44 GHz, with absorbance of 98.8%, 99.7%, and 98.3%, respectively, which agree well with an experiment. Simulated surface current distributions of the unit-cell structure reveal that the triple-band absorption mainly originates from multiple-harmonic magnetic resonance. The proposed triple-band MMA can remain at a high absorption level for all polarization of both transverse-electric (TE) and transverse-magnetic (TM) modes under normal incidence. Moreover, by further optimizing the geometric parameters of the CSRs, four-band and five-band MMAs can also be obtained. Thus, our design will have potential application in detection, sensing, and stealth technology. PMID:29077036

Concerted Dynamic Motions of an FABP4 Model and Its Ligands Revealed by Microsecond Molecular Dynamics Simulations

PubMed Central

2015-01-01

In this work, we investigate the dynamic motions of fatty acid binding protein 4 (FABP4) in the absence and presence of a ligand by explicitly solvated all-atom molecular dynamics simulations. The dynamics of one ligand-free FABP4 and four ligand-bound FABP4s is compared via multiple 1.2 μs simulations. In our simulations, the protein interconverts between the open and closed states. Ligand-free FABP4 prefers the closed state, whereas ligand binding induces a conformational transition to the open state. Coupled with opening and closing of FABP4, the ligand adopts distinct binding modes, which are identified and compared with crystal structures. The concerted dynamics of protein and ligand suggests that there may exist multiple FABP4–ligand binding conformations. Thus, this work provides details about how ligand binding affects the conformational preference of FABP4 and how ligand binding is coupled with a conformational change of FABP4 at an atomic level. PMID:25231537

Concerted dynamic motions of an FABP4 model and its ligands revealed by microsecond molecular dynamics simulations.

PubMed

Li, Yan; Li, Xiang; Dong, Zigang

2014-10-14

In this work, we investigate the dynamic motions of fatty acid binding protein 4 (FABP4) in the absence and presence of a ligand by explicitly solvated all-atom molecular dynamics simulations. The dynamics of one ligand-free FABP4 and four ligand-bound FABP4s is compared via multiple 1.2 μs simulations. In our simulations, the protein interconverts between the open and closed states. Ligand-free FABP4 prefers the closed state, whereas ligand binding induces a conformational transition to the open state. Coupled with opening and closing of FABP4, the ligand adopts distinct binding modes, which are identified and compared with crystal structures. The concerted dynamics of protein and ligand suggests that there may exist multiple FABP4-ligand binding conformations. Thus, this work provides details about how ligand binding affects the conformational preference of FABP4 and how ligand binding is coupled with a conformational change of FABP4 at an atomic level.

Gas Production Strategy of Underground Coal Gasification Based on Multiple Gas Sources

PubMed Central

Tianhong, Duan; Zuotang, Wang; Limin, Zhou; Dongdong, Li

2014-01-01

To lower stability requirement of gas production in UCG (underground coal gasification), create better space and opportunities of development for UCG, an emerging sunrise industry, in its initial stage, and reduce the emission of blast furnace gas, converter gas, and coke oven gas, this paper, for the first time, puts forward a new mode of utilization of multiple gas sources mainly including ground gasifier gas, UCG gas, blast furnace gas, converter gas, and coke oven gas and the new mode was demonstrated by field tests. According to the field tests, the existing power generation technology can fully adapt to situation of high hydrogen, low calorific value, and gas output fluctuation in the gas production in UCG in multiple-gas-sources power generation; there are large fluctuations and air can serve as a gasifying agent; the gas production of UCG in the mode of both power and methanol based on multiple gas sources has a strict requirement for stability. It was demonstrated by the field tests that the fluctuations in gas production in UCG can be well monitored through a quality control chart method. PMID:25114953

Mode of de-esterification of alkaline and acidic pectin methyl esterases at different pH conditions.

PubMed

Duvetter, Thomas; Fraeye, Ilse; Sila, Daniel N; Verlent, Isabel; Smout, Chantal; Hendrickx, Marc; Van Loey, Ann

2006-10-04

Highly esterified citrus pectin was de-esterified at pH 4.5 and 8.0 by a fungal pectin methyl esterase (PME) that was shown to have an acidic isoelectric pH (pI) and an acidic pH optimum and by a plant PME that was characterized by an alkaline pI and an alkaline pH optimum. Interchain and intrachain de-esterification patterns were studied by digestion of the pectin products with endo-polygalacturonase and subsequent analysis using size exclusion and anion-exchange chromatography. No effect of pH was observed on the de-esterification mode of either of the two enzymes. Acidic, fungal PME converted pectin according to a multiple-chain mechanism, with a limited degree of multiple attack at the intrachain level, both at pH 4.5 and at pH 8.0. A multiple-attack mechanism, with a high degree of multiple attack, was more appropriate to describe the action mode of alkaline, plant PME, both at pH 4.5 and at pH 8.0.

Gas production strategy of underground coal gasification based on multiple gas sources.

PubMed

Tianhong, Duan; Zuotang, Wang; Limin, Zhou; Dongdong, Li

2014-01-01

To lower stability requirement of gas production in UCG (underground coal gasification), create better space and opportunities of development for UCG, an emerging sunrise industry, in its initial stage, and reduce the emission of blast furnace gas, converter gas, and coke oven gas, this paper, for the first time, puts forward a new mode of utilization of multiple gas sources mainly including ground gasifier gas, UCG gas, blast furnace gas, converter gas, and coke oven gas and the new mode was demonstrated by field tests. According to the field tests, the existing power generation technology can fully adapt to situation of high hydrogen, low calorific value, and gas output fluctuation in the gas production in UCG in multiple-gas-sources power generation; there are large fluctuations and air can serve as a gasifying agent; the gas production of UCG in the mode of both power and methanol based on multiple gas sources has a strict requirement for stability. It was demonstrated by the field tests that the fluctuations in gas production in UCG can be well monitored through a quality control chart method.

Influence of the Spatial Dimensions of Ultrasonic Transducers on the Frequency Spectrum of Guided Waves.

PubMed

Samaitis, Vykintas; Mažeika, Liudas

2017-08-08

Ultrasonic guided wave (UGW)-based condition monitoring has shown great promise in detecting, localizing, and characterizing damage in complex systems. However, the application of guided waves for damage detection is challenging due to the existence of multiple modes and dispersion. This results in distorted wave packets with limited resolution and the interference of multiple reflected modes. To develop reliable inspection systems, either the transducers have to be optimized to generate a desired single mode of guided waves with known dispersive properties, or the frequency responses of all modes present in the structure must be known to predict wave interaction. Currently, there is a lack of methods to predict the response spectrum of guided wave modes, especially in cases when multiple modes are being excited simultaneously. Such methods are of vital importance for further understanding wave propagation within the structures as well as wave-damage interaction. In this study, a novel method to predict the response spectrum of guided wave modes was proposed based on Fourier analysis of the particle velocity distribution on the excitation area. The method proposed in this study estimates an excitability function based on the spatial dimensions of the transducer, type of vibration, and dispersive properties of the medium. As a result, the response amplitude as a function of frequency for each guided wave mode present in the structure can be separately obtained. The method was validated with numerical simulations on the aluminum and glass fiber composite samples. The key findings showed that it can be applied to estimate the response spectrum of a guided wave mode on any type of material (either isotropic structures, or multi layered anisotropic composites) and under any type of excitation if the phase velocity dispersion curve and the particle velocity distribution of the wave source was known initially. Thus, the proposed method may be a beneficial tool to explain and predict the response spectrum of guided waves throughout the development of any structural health monitoring system.

Influence of the Spatial Dimensions of Ultrasonic Transducers on the Frequency Spectrum of Guided Waves

PubMed Central

Samaitis, Vykintas; Mažeika, Liudas

2017-01-01

Ultrasonic guided wave (UGW)-based condition monitoring has shown great promise in detecting, localizing, and characterizing damage in complex systems. However, the application of guided waves for damage detection is challenging due to the existence of multiple modes and dispersion. This results in distorted wave packets with limited resolution and the interference of multiple reflected modes. To develop reliable inspection systems, either the transducers have to be optimized to generate a desired single mode of guided waves with known dispersive properties, or the frequency responses of all modes present in the structure must be known to predict wave interaction. Currently, there is a lack of methods to predict the response spectrum of guided wave modes, especially in cases when multiple modes are being excited simultaneously. Such methods are of vital importance for further understanding wave propagation within the structures as well as wave-damage interaction. In this study, a novel method to predict the response spectrum of guided wave modes was proposed based on Fourier analysis of the particle velocity distribution on the excitation area. The method proposed in this study estimates an excitability function based on the spatial dimensions of the transducer, type of vibration, and dispersive properties of the medium. As a result, the response amplitude as a function of frequency for each guided wave mode present in the structure can be separately obtained. The method was validated with numerical simulations on the aluminum and glass fiber composite samples. The key findings showed that it can be applied to estimate the response spectrum of a guided wave mode on any type of material (either isotropic structures, or multi layered anisotropic composites) and under any type of excitation if the phase velocity dispersion curve and the particle velocity distribution of the wave source was known initially. Thus, the proposed method may be a beneficial tool to explain and predict the response spectrum of guided waves throughout the development of any structural health monitoring system. PMID:28786924

Spectroscopic pulsational frequency identification and mode determination of γ Doradus star HD 12901

NASA Astrophysics Data System (ADS)

Brunsden, E.; Pollard, K. R.; Cottrell, P. L.; Wright, D. J.; De Cat, P.

2012-12-01

Using multisite spectroscopic data collected from three sites, the frequencies and pulsational modes of the γ Doradus star HD 12901 were identified. A total of six frequencies in the range 1-2 d-1 were observed, their identifications supported by multiple line-profile measurement techniques and previously published photometry. Five frequencies were of sufficient signal-to-noise ratio for mode identification, and all five displayed similar three-bump standard deviation profiles which were fitted well with (l,m) = (1,1) modes. These fits had reduced χ2 values of less than 18. We propose that this star is an excellent candidate to test models of non-radially pulsating γ Doradus stars as a result of the presence of multiple (1,1) modes. This paper includes data taken at the Mount John University Observatory of the University of Canterbury (New Zealand), the McDonald Observatory of the University of Texas at Austin (Texas, USA) and the European Southern Observatory at La Silla (Chile).

Current profile redistribution driven by neutral beam injection in a reversed-field pinch

NASA Astrophysics Data System (ADS)

Parke, E.; Anderson, J. K.; Brower, D. L.; Den Hartog, D. J.; Ding, W. X.; Johnson, C. A.; Lin, L.

2016-05-01

Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm with neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q0 by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].

Observation of trapped-electron-mode microturbulence in reversed field pinch plasmas

NASA Astrophysics Data System (ADS)

Duff, J. R.; Williams, Z. R.; Brower, D. L.; Chapman, B. E.; Ding, W. X.; Pueschel, M. J.; Sarff, J. S.; Terry, P. W.

2018-01-01

Density fluctuations in the large-density-gradient region of improved confinement Madison Symmetric Torus reversed field pinch (RFP) plasmas exhibit multiple features that are characteristic of the trapped-electron mode (TEM). Core transport in conventional RFP plasmas is governed by magnetic stochasticity stemming from multiple long-wavelength tearing modes. Using inductive current profile control, these tearing modes are reduced, and global confinement is increased to that expected for comparable tokamak plasmas. Under these conditions, new short-wavelength fluctuations distinct from global tearing modes appear in the spectrum at a frequency of f ˜ 50 kHz, which have normalized perpendicular wavenumbers k⊥ρs≲ 0.2 and propagate in the electron diamagnetic drift direction. They exhibit a critical-gradient threshold, and the fluctuation amplitude increases with the local electron density gradient. These characteristics are consistent with predictions from gyrokinetic analysis using the Gene code, including increased TEM turbulence and transport from the interaction of remnant tearing magnetic fluctuations and zonal flow.

Drift Wave Simulation in Toroidal Geometry.

NASA Astrophysics Data System (ADS)

Lebrun, Maurice Joseph, III

1988-12-01

The drift wave, a general category of plasma behavior arising from a plasma inhomogeneity, is studied using the particle simulation method. In slab geometry, the drift wave (or universal mode) is stabilized by any finite amount of magnetic shear. In toroidal geometry, however, the coupling of the poloidal harmonics gives rise to a new branch of drift wave eigenmodes called the toroidicity -induced mode, which is predicted to be unstable in some regimes. The drift wave in a toroidal system is intrinsically three-dimensional, and is sensitive to the handling of the parallel electron dynamics, the (nearly) perpendicular wave dynamics, and the radial variation of magnetic field vector (shear). A simulation study must therefore be kinetic in nature, motivating the extension of particle simulation techniques to complex geometries. From this effort a three dimensional particle code in a toroidal coordinate system has been developed and applied to the toroidal drift wave problem. The code uses an (r,theta,phi) -type coordinate system, and a nonuniform radial grid that increases resolution near the mode-rational surfaces. Full ion dynamics and electron guiding center dynamics are employed. Further, the algorithm incorporates a straightforward limiting process to cylindrical geometry and slab geometry, enabling comparison to the theoretical results in these regimes. Simulations of the density-driven modes in toroidal geometry retain a single toroidal mode number (n = 9). In this regime, the poloidal harmonics are expected to be strongly coupled, giving rise to the marginally unstable toroidicity-induced drift mode. Analysis of the simulation data reveals a strong, low-frequency response that peaks near each mode rational surface. Further, the characteristic oscillation frequencies persist from one mode rational surface to the next, which identifies them as multiple harmonics of the toroidicity-induced mode. The lowest harmonic occurs at a frequency of omega/ omega^{*} ~ 0.26, which is reasonably close to the prediction of linear theory. Interferogram analysis of these modes indicates a "ballooning" structure toward the outside of the torus. The amplitude of the potential is observed to grow exponentially for the m = 8 through m = 10 poloidal mode numbers, with a growth rate of approximately gamma/omega ^{*} ~ 0.075. Saturation occurs at time t ~ 1000 Omega_sp{i}{-1}, and may be caused by quasilinear flattening of the density profile.

Plastic Responses of a Sessile Prey to Multiple Predators: A Field and Experimental Study

PubMed Central

Hirsch, Philipp Emanuel; Cayon, David; Svanbäck, Richard

2014-01-01

Background Theory predicts that prey facing a combination of predators with different feeding modes have two options: to express a response against the feeding mode of the most dangerous predator, or to express an intermediate response. Intermediate phenotypes protect equally well against several feeding modes, rather than providing specific protection against a single predator. Anti-predator traits that protect against a common feeding mode displayed by all predators should be expressed regardless of predator combination, as there is no need for trade-offs. Principal Findings We studied phenotypic anti-predator responses of zebra mussels to predation threat from a handling-time-limited (crayfish) and a gape-size-limited (roach) predator. Both predators dislodge mussels from the substrate but diverge in their further feeding modes. Mussels increased expression of a non-specific defense trait (attachment strength) against all combinations of predators relative to a control. In response to roach alone, mussels showed a tendency to develop a weaker and more elongated shell. In response to crayfish, mussels developed a harder and rounder shell. When exposed to either a combination of predators or no predator, mussels developed an intermediate phenotype. Mussel growth rate was positively correlated with an elongated weaker shell and negatively correlated with a round strong shell, indicating a trade-off between anti-predator responses. Field observations of prey phenotypes revealed the presence of both anti-predator phenotypes and the trade-off with growth, but intra-specific population density and bottom substrate had a greater influence than predator density. Conclusions Our results show that two different predators can exert both functionally equivalent and inverse selection pressures on a single prey. Our field study suggests that abiotic factors and prey population density should be considered when attempting to explain phenotypic diversity in the wild. PMID:25517986

On the onset of surface condensation: formation and transition mechanisms of condensation mode

PubMed Central

Sheng, Qiang; Sun, Jie; Wang, Qian; Wang, Wen; Wang, Hua Sheng

2016-01-01

Molecular dynamics simulations have been carried out to investigate the onset of surface condensation. On surfaces with different wettability, we snapshot different condensation modes (no-condensation, dropwise condensation and filmwise condensation) and quantitatively analyze their characteristics by temporal profiles of surface clusters. Two different types of formation of nanoscale droplets are identified, i.e. the formations with and without film-like condensate. We exhibit the effect of surface tensions on the formations of nanoscale droplets and film. We reveal the formation mechanisms of different condensation modes at nanoscale based on our simulation results and classical nucleation theory, which supplements the ‘classical hypotheses’ of the onset of dropwise condensation. We also reveal the transition mechanism between different condensation modes based on the competition between surface tensions and reveal that dropwise condensation represents the transition states from no-condensation to filmwise condensation. PMID:27481071

On the onset of surface condensation: formation and transition mechanisms of condensation mode.

PubMed

Sheng, Qiang; Sun, Jie; Wang, Qian; Wang, Wen; Wang, Hua Sheng

2016-08-02

Molecular dynamics simulations have been carried out to investigate the onset of surface condensation. On surfaces with different wettability, we snapshot different condensation modes (no-condensation, dropwise condensation and filmwise condensation) and quantitatively analyze their characteristics by temporal profiles of surface clusters. Two different types of formation of nanoscale droplets are identified, i.e. the formations with and without film-like condensate. We exhibit the effect of surface tensions on the formations of nanoscale droplets and film. We reveal the formation mechanisms of different condensation modes at nanoscale based on our simulation results and classical nucleation theory, which supplements the 'classical hypotheses' of the onset of dropwise condensation. We also reveal the transition mechanism between different condensation modes based on the competition between surface tensions and reveal that dropwise condensation represents the transition states from no-condensation to filmwise condensation.

The additional-mode garden of RR Lyrae stars

NASA Astrophysics Data System (ADS)

Molnár, László; Plachy, Emese; Klagyivik, Péter; Juhász, Áron L.; Szabó, Róbert; D'Alessandro, Zachary; Kratz, Benjamin; Ortega, Justin; Kanbur, Shashi

2017-10-01

Space-based photometric missions revealed a surprising abundance of millimagnitude-level additional modes in RR Lyrae stars. The modes that appear in the modulated fundamental-mode (RRab) stars can be ordered into four major categories. Here we present the distribution of these groups in the Petersen diagram, and discuss their characteristics and connections to additional modes observed in other RR Lyrae stars.

Excitation of surface plasmon polariton modes with multiple nitrogen vacancy centers in single nanodiamonds

NASA Astrophysics Data System (ADS)

Kumar, Shailesh; Lausen, Jens L.; Garcia-Ortiz, Cesar E.; Andersen, Sebastian K. H.; Roberts, Alexander S.; Radko, Ilya P.; Smith, Cameron L. C.; Kristensen, Anders; Bozhevolnyi, Sergey I.

2016-02-01

Nitrogen-vacancy (NV) centers in diamonds are interesting due to their remarkable characteristics that are well suited to applications in quantum-information processing and magnetic field sensing, as well as representing stable fluorescent sources. Multiple NV centers in nanodiamonds (NDs) are especially useful as biological fluorophores due to their chemical neutrality, brightness and room-temperature photostability. Furthermore, NDs containing multiple NV centers also have potential in high-precision magnetic field and temperature sensing. Coupling NV centers to propagating surface plasmon polariton (SPP) modes gives a base for lab-on-a-chip sensing devices, allows enhanced fluorescence emission and collection which can further enhance the precision of NV-based sensors. Here, we investigate coupling of multiple NV centers in individual NDs to the SPP modes supported by silver surfaces protected by thin dielectric layers and by gold V-grooves (VGs) produced via the self-terminated silicon etching. In the first case, we concentrate on monitoring differences in fluorescence spectra obtained from a source ND, which is illuminated by a pump laser, and from a scattering ND illuminated only by the fluorescence-excited SPP radiation. In the second case, we observe changes in the average NV lifetime when the same ND is characterized outside and inside a VG. Fluorescence emission from the VG terminations is also observed, which confirms the NV coupling to the VG-supported SPP modes.

Ground state, collective mode, phase soliton and vortex in multiband superconductors.

PubMed

Lin, Shi-Zeng

2014-12-10

This article reviews theoretical and experimental work on the novel physics in multiband superconductors. Multiband superconductors are characterized by multiple superconducting energy gaps in different bands with interaction between Cooper pairs in these bands. The discovery of prominent multiband superconductors MgB2 and later iron-based superconductors, has triggered enormous interest in multiband superconductors. The most recently discovered superconductors exhibit multiband features. The multiband superconductors possess novel properties that are not shared with their single-band counterpart. Examples include: the time-reversal symmetry broken state in multiband superconductors with frustrated interband couplings; the collective oscillation of number of Cooper pairs between different bands, known as the Leggett mode; and the phase soliton and fractional vortex, which are the main focus of this review. This review presents a survey of a wide range of theoretical exploratory and experimental investigations of novel physics in multiband superconductors. A vast amount of information derived from these studies is shown to highlight unusual and unique properties of multiband superconductors and to reveal the challenges and opportunities in the research on the multiband superconductivity.

The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.

PubMed

Liu, Jiuyang; Li, Fudong; Bao, Hongyu; Jiang, Yiyang; Zhang, Shuya; Ma, Rongsheng; Gao, Jia; Wu, Jihui; Ruan, Ke

2017-04-01

Tripartite motif-containing protein 24 (TRIM24) is closely correlated with multiple cancers, and a recent study demonstrated that the bromodomain of TRIM24 is essential for the proliferation of lethal castration-resistant prostate cancer. Here, we identify three new inhibitors of the TRIM24 bromodomain using NMR fragment-based screening. The crystal structures of two new inhibitors in complex with the TRIM24 bromodomain reveal that the water-bridged interaction network is conserved in the same fashion as those for known benzoimidazolone inhibitors. Interestingly, the polar substitution on the warhead of one new inhibitor pulls the whole ligand approximately 2 Å into the inner side pocket of the TRIM24 bromodomain, and thus exhibits a binding mode significantly different from other known bromodomain ligands. This mode provides a useful handle for further hit-to-lead evolution toward novel inhibitors of the TRIM24 bromodomain. Structural data are available in the PDB under the accession numbers 5H1T, 5H1U, and 5H1V. © 2017 Federation of European Biochemical Societies.

Global Surface Temperature Anomalies and Attribution

NASA Astrophysics Data System (ADS)

Pietrafesa, L. J.

2017-12-01

We study Non-Stationary, Non-Linear time series of global surface temperatures from 1850 to 2016, and via an empirical, mathematical methodology, we reveal the buried, internal modes of variability of planetary temperatures over the past 167 years, and find periods of cooling and warming, both in the ocean and the atmosphere over land, with multiple modes of variability; seasonal, annual, inter-annual, multi-year, decadal, multi-decadal, centennial and overall warming trends in the ocean, atmosphere and the combination therein. The oceanic rate of warming is less than two thirds of that of the atmosphere. While our findings on overall trends of fossil fuel burning and planetary temperatures are only visually correlative, by employing a mathematical methodology well known in ergonomics, this study causally links the upward rise in planetary surface temperature from the latter part of the 19th Century and into the 21st Century, to the contemporaneous upward rise in fossil fuel burning and suggests that if present fossil fuel burning is not curtailed there will be continued warming of the planet in the future.

Formulation of an explicit-multiple-time-step time integration method for use in a global primitive equation grid model

NASA Technical Reports Server (NTRS)

Chao, W. C.

1982-01-01

With appropriate modifications, a recently proposed explicit-multiple-time-step scheme (EMTSS) is incorporated into the UCLA model. In this scheme, the linearized terms in the governing equations that generate the gravity waves are split into different vertical modes. Each mode is integrated with an optimal time step, and at periodic intervals these modes are recombined. The other terms are integrated with a time step dictated by the CFL condition for low-frequency waves. This large time step requires a special modification of the advective terms in the polar region to maintain stability. Test runs for 72 h show that EMTSS is a stable, efficient and accurate scheme.

Tunable arbitrary unitary transformer based on multiple sections of multicore fibers with phase control.

PubMed

Zhou, Junhe; Wu, Jianjie; Hu, Qinsong

2018-02-05

In this paper, we propose a novel tunable unitary transformer, which can achieve arbitrary discrete unitary transforms. The unitary transformer is composed of multiple sections of multi-core fibers with closely aligned coupled cores. Phase shifters are inserted before and after the sections to control the phases of the waves in the cores. A simple algorithm is proposed to find the optimal phase setup for the phase shifters to realize the desired unitary transforms. The proposed device is fiber based and is particularly suitable for the mode division multiplexing systems. A tunable mode MUX/DEMUX for a three-mode fiber is designed based on the proposed structure.

Shuttle ku-band communications/radar technical concepts

NASA Technical Reports Server (NTRS)

Griffin, J. W.; Kelley, J. S.; Steiner, A. W.; Vang, H. A.; Zrubek, W. E.; Huth, G. K.

1985-01-01

Technical data on the Shuttle Orbiter K sub u-band communications/radar system are presented. The more challenging aspects of the system design and development are emphasized. The technical problems encountered and the advancements made in solving them are discussed. The radar functions are presented first. Requirements and design/implementation approaches are discussed. Advanced features are explained, including Doppler measurement, frequency diversity, multiple pulse repetition frequencies and pulse widths, and multiple modes. The communications functions that are presented include advances made because of the requirements for multiple communications modes. Spread spectrum, quadrature phase shift keying (QPSK), variable bit rates, and other advanced techniques are discussed. Performance results and conclusions reached are outlined.

Extracting the information of coastline shape and its multiple representations

NASA Astrophysics Data System (ADS)

Liu, Ying; Li, Shujun; Tian, Zhen; Chen, Huirong

2007-06-01

According to studying the coastline, a new way of multiple representations is put forward in the paper. That is stimulating human thinking way when they generalized, building the appropriate math model and describing the coastline with graphics, extracting all kinds of the coastline shape information. The coastline automatic generalization will be finished based on the knowledge rules and arithmetic operators. Showing the information of coastline shape by building the curve Douglas binary tree, it can reveal the shape character of coastline not only microcosmically but also macroscopically. Extracting the information of coastline concludes the local characteristic point and its orientation, the curve structure and the topology trait. The curve structure can be divided the single curve and the curve cluster. By confirming the knowledge rules of the coastline generalization, the generalized scale and its shape parameter, the coastline automatic generalization model is established finally. The method of the multiple scale representation of coastline in this paper has some strong points. It is human's thinking mode and can keep the nature character of the curve prototype. The binary tree structure can control the coastline comparability, avoid the self-intersect phenomenon and hold the unanimous topology relationship.

Rogue waves and W-shaped solitons in the multiple self-induced transparency system.

PubMed

Wang, Xin; Liu, Chong; Wang, Lei

2017-09-01

We study localized nonlinear waves on a plane wave background in the multiple self-induced transparency (SIT) system, which describes an important enhancement of the amplification and control of optical waves compared to the single SIT system. A hierarchy of exact multiparametric rational solutions in a compact determinant representation is presented. We demonstrate that this family of solutions contain known rogue wave solutions and unusual W-shaped soliton solutions. State transitions between the fundamental rogue waves and W-shaped solitons as well as higher-order nonlinear superposition modes are revealed in the zero-frequency perturbation region by the suitable choice for the background wavenumber of the electric field component. Particularly, it is found that the multiple SIT system can admit both stationary and nonstationary W-shaped solitons in contrast to the stationary results in the single SIT system. Moreover, the W-shaped soliton complex which is formed by a certain number of fundamental W-shaped solitons with zero phase parameters and its decomposition mechanism in the case of the nonzero phase parameters are shown. Meanwhile, some important characteristics of the nonlinear waves including trajectories and spectrum are discussed through the numerical and analytical methods.

Incremental dynamical downscaling for probabilistic analysis based on multiple GCM projections

NASA Astrophysics Data System (ADS)

Wakazuki, Y.

2015-12-01

A dynamical downscaling method for probabilistic regional scale climate change projections was developed to cover an uncertainty of multiple general circulation model (GCM) climate simulations. The climatological increments (future minus present climate states) estimated by GCM simulation results were statistically analyzed using the singular vector decomposition. Both positive and negative perturbations from the ensemble mean with the magnitudes of their standard deviations were extracted and were added to the ensemble mean of the climatological increments. The analyzed multiple modal increments were utilized to create multiple modal lateral boundary conditions for the future climate regional climate model (RCM) simulations by adding to an objective analysis data. This data handling is regarded to be an advanced method of the pseudo-global-warming (PGW) method previously developed by Kimura and Kitoh (2007). The incremental handling for GCM simulations realized approximated probabilistic climate change projections with the smaller number of RCM simulations. Three values of a climatological variable simulated by RCMs for a mode were used to estimate the response to the perturbation of the mode. For the probabilistic analysis, climatological variables of RCMs were assumed to show linear response to the multiple modal perturbations, although the non-linearity was seen for local scale rainfall. Probability of temperature was able to be estimated within two modes perturbation simulations, where the number of RCM simulations for the future climate is five. On the other hand, local scale rainfalls needed four modes simulations, where the number of the RCM simulations is nine. The probabilistic method is expected to be used for regional scale climate change impact assessment in the future.

The impact of embedding multiple modes of representation on student construction of chemistry knowledge

NASA Astrophysics Data System (ADS)

McDermott, Mark Andrew

2009-12-01

This study was designed to examine the impact of embedding multiple modes of representing science information on student conceptual understanding in science. Multiple representations refer to utilizing charts, graphs, diagrams, and other types of representations to communicate scientific information. This study investigated the impact of encouraging students to embed or integrate the multiple modes with text in end of unit writing-to-learn activities. A quasi-experimental design with four separate sites consisting of intact chemistry classes taught by different teachers at each site was utilized. At each site, approximately half of the classes were designated treatment classes and students in these classes participated in activities designed to encourage strategies to embed multiple modes within text in student writing. The control classes did not participate in these activities. All classes participated in identical end of unit writing tasks in which they were required to use at least one mode other than text, followed by identical end of unit assessments. This progression was then repeated for a second consecutive unit of study. Analysis of quantitative data indicated that in several cases, treatment classes significantly outperformed control classes both on measures of embeddedness in writing and on end of unit assessment measures. In addition, analysis at the level of individual students indicated significant positive correlations in many cases between measures of student embeddedness in writing and student performance on end of unit assessments. Three factors emerged as critical in increasing the likelihood of benefit for students from these types of activities. First, the level of teacher implementation and emphasis on the embeddedness lessons was linked to the possibility of conceptual benefit. Secondly, students participating in two consecutive lessons appeared to receive greater benefit during the second unit, inferring a cumulative benefit. Finally, differential impact of the degree of embeddedness on student performance was noted based on student's level of science ability prior to the initiation of study procedures.

Intensity fluctuations in bimodal micropillar lasers enhanced by quantum-dot gain competition

NASA Astrophysics Data System (ADS)

Leymann, H. A. M.; Hopfmann, C.; Albert, F.; Foerster, A.; Khanbekyan, M.; Schneider, C.; Höfling, S.; Forchel, A.; Kamp, M.; Wiersig, J.; Reitzenstein, S.

2013-05-01

We investigate correlations between orthogonally polarized cavity modes of a bimodal micropillar laser with a single layer of self-assembled quantum dots in the active region. While one emission mode of the microlaser demonstrates a characteristic S-shaped input-output curve, the output intensity of the second mode saturates and even decreases with increasing injection current above threshold. Measuring the photon autocorrelation function g(2)(τ) of the light emission confirms the onset of lasing in the first mode with g(2)(0) approaching unity above threshold. In contrast, strong photon bunching associated with superthermal values of g(2)(0) is detected for the other mode for currents above threshold. This behavior is attributed to gain competition of the two modes induced by the common gain material, which is confirmed by photon cross-correlation measurements revealing a clear anticorrelation between emission events of the two modes. The experimental studies are in qualitative agreement with theoretical studies based on a microscopic semiconductor theory, which we extend to the case of two modes interacting with the common gain medium. Moreover, we treat the problem by a phenomenological birth-death model extended to two interacting modes, which reveals that the photon probability distribution of each mode has a double-peak structure, indicating switching behavior of the modes for pump rates around threshold.

Multiplicity of transmission coefficients in photonic crystal and split ring resonator waveguides with Kerr nonlinear impurities

NASA Astrophysics Data System (ADS)

Rai, Buddhi; McGurn, Arthur R.

2015-02-01

Photonic crystal and split ring resonator (SRR) metamaterial waveguides with Kerr nonlinear dielectric impurities are studied. The transmission coefficients for two guided modes of different frequencies scattering from the Kerr impurities are computed. The systems are shown to exhibit multiple transmission coefficient solutions arising from the Kerr nonlinearity. Multiple transmission coefficients occur when different input intensities into a waveguide result in the same transmitted output intensities past its nonlinear impurities. (In the case of a single incident guided mode the multiplicity of transmission coefficients is known as optical bistability.) The analytical conditions under which the transmission coefficients are single and multiple valued are determined, and specific examples of both single and multiple valued transmission coefficient scattering are presented. Both photonic crystal and split ring resonator systems are studied as the Kerr nonlinearity enters the photonic crystal and SRR systems in different ways. This allows for an interesting comparison of the differences in behaviors of these two types of system which are described by distinctly different mathematical structures. Both the photonic crystal and SRR models used in the calculations are based on a difference equation approach to the system dynamics. The difference equation approach has been extensively employed in previous papers to model the basic properties of these systems. The paper is a continuation of work on the optical bistability of single guided modes interacting with Kerr impurities in photonic crystals originally considered by McGurn [Chaos 13, 754 (2003), 10.1063/1.1568691] and work on the resonant scattering from Kerr impurities in photonic crystal waveguides considered by McGurn [J. Phys.: Condens. Matter 16, S5243 (2004), 10.1088/0953-8984/16/44/021]. It generalizes this work making the extension to the more complex interaction of two guided modes at different frequencies. It extends the two guided mode treatment by McGurn [Organ. Electron. 8, 227 (2007), 10.1016/j.orgel.2006.06.008] which was limited to a special case of one of the photonic crystal systems considered here.

MIMO capacities and outage probabilities in spatially multiplexed optical transport systems.

PubMed

Winzer, Peter J; Foschini, Gerard J

2011-08-15

With wavelength-division multiplexing (WDM) rapidly nearing its scalability limits, space-division multiplexing (SDM) seems the only option to further scale the capacity of optical transport networks. In order for SDM systems to continue the WDM trend of reducing energy and cost per bit with system capacity, integration will be key to SDM. Since integration is likely to introduce non-negligible crosstalk between multiple parallel transmission paths, multiple-input multiple output (MIMO) signal processing techniques will have to be used. In this paper, we discuss MIMO capacities in optical SDM systems, including related outage considerations which are an important part in the design of such systems. In order to achieve the low-outage standards required for optical transport networks, SDM transponders should be capable of individually addressing, and preferably MIMO processing all modes supported by the optical SDM waveguide. We then discuss the effect of distributed optical noise in MIMO SDM systems and focus on the impact of mode-dependent loss (MDL) on system capacity and system outage. Through extensive numerical simulations, we extract scaling rules for mode-average and mode-dependent loss and show that MIMO SDM systems composed of up to 128 segments and supporting up to 128 modes can tolerate up to 1 dB of per-segment MDL at 90% of the system's full capacity at an outage probability of 10(-4). © 2011 Optical Society of America

Trophic segregation of a fish assemblage along lateral depth gradients in a subtropical coastal lagoon revealed by stable isotope analyses.

PubMed

Mont'Alverne, R; Pereyra, P E R; Garcia, A M

2016-07-01

Stable isotopes were used to evaluate the hypothesis that fish assemblages occurring in shallow and deep areas of a large coastal lagoon are structured in partially segregated trophic modules with consumers showing contrasting reliance on benthic or pelagic food sources. The results revealed that fishes in deep areas were mainly dependent on particulate organic matter in the sediment (SOM), whereas emergent macrophytes were as important as SOM to fish consumers in shallow areas. Conceptual trophic diagrams depicting relationships among basal food sources and consumers in different regions of the lagoon highlighted the greater use of multiple basal food sources by more feeding mode functional guilds in shallow water compared with the use of predominantly benthic resources (SOM) in deep areas. The findings appear to corroborate the initial hypothesis and offer complementary perspectives in understanding the role of spatial ecology in structuring coastal ecosystem function and productivity. © 2016 The Fisheries Society of the British Isles.

Optoelectronic Devices with Complex Failure Modes

NASA Technical Reports Server (NTRS)

Johnston, A.

2000-01-01

This part of the NSREC-2000 Short Course discusses radiation effects in basic photonic devices along with effects in more complex optoelectronic devices where the overall radiation response depends on several factors, with the possibility of multiple failure modes.

A nonlinear multi-mode wideband piezoelectric vibration-based energy harvester using compliant orthoplanar spring

NASA Astrophysics Data System (ADS)

Dhote, Sharvari; Zu, Jean; Zhu, Yang

2015-04-01

In this paper, a nonlinear wideband multi-mode piezoelectric vibration-based energy harvester (PVEH) is proposed based on a compliant orthoplanar spring (COPS), which has an advantage of providing multiple vibration modes at relatively low frequencies. The PVEH is made of a tri-leg COPS flexible structure, where three fixed-guided beams are capable of generating strong nonlinear oscillations under certain base excitation. A prototype harvester was fabricated and investigated through both finite-element analysis and experiments. The frequency response shows multiple resonance which corresponds to a hardening type of nonlinear resonance. By adding masses at different locations on the COPS structure, the first three vibration modes are brought close to each other, where the three hardening nonlinear resonances provide a wide bandwidth for the PVEH. The proposed PVEH has enhanced performance of the energy harvester in terms of a wide frequency bandwidth and a high-voltage output under base excitations.

Comparisons of Remote Sensing Retrievals and in situ Measurements of Aerosol Fine Mode Fraction during ACE-Asia

NASA Technical Reports Server (NTRS)

Gasso, Santiago; O'Neill, Norm

2006-01-01

We present sunphotometer-retrieved and in situ fine mode fractions (FMF) measured onboard the same aircraft during the ACE-Asia experiment. Comparisons indicate that the latter can be used to identify whether the aerosol under observation is dominated by a mixture of modes or a single mode. Differences between retrieved and in situ FMF range from 5-20%. When profiles contained multiple layers of aerosols, the retrieved and measured FMF were segregated by layers. The comparison of layered and total FMF from the same profile indicates that columnar values are intermediate to those derived from layers. As a result, a remotely sensed FMF cannot be used to distinguish whether the aerosol under observation is composed of layers each with distinctive modal features or all layers with the same modal features. Thus, the use of FMF in multiple layer environments does not provide unique information on the aerosol under observation.

Multiple period s-p hybridization in nano-strip embedded photonic crystal.

PubMed

Han, Seunghoon; Lee, Il-Min; Kim, Hwi; Lee, Byoungho

2005-04-04

We report and analyze hybridization of s-state and p-state modes in photonic crystal one-dimensional defect cavity array. When embedding a nano-strip into a dielectric rod photonic crystal, an effective cavity array is made, where each cavity possesses two cavity modes: s-state and p-state. The two modes are laterally even versus the nano-strip direction, and interact with each other, producing defect bands, of which the group velocity becomes zero within the first Brillouin zone. We could model and describe the phenomena by using the tight-binding method, well agreeing with the plane-wave expansion method analysis. We note that the reported s- and p-state mode interaction corresponds to the hybridization of atomic orbital in solid-state physics. The concept of multiple period s-p hybridization and the proposed model can be useful for analyzing and developing novel photonic crystal waveguides and devices.

Bandwidth Extension of an S-band, Fundamental-Mode Eight-Beam Klystron

DTIC Science & Technology

2006-04-01

Extension of an S - band , Fundamental-Mode Eight-Beam Klystron Khanh T. Nguyen Beam-Wave Research, Inc. Bethesda, MD 20814 Dean E. Pershing ATK Mission...of a five-cavity, approximately 18 cm downstream from the center of the broadband, high - power multiple-beam klystron (MBK) first gap - the logical...the circuit generates >550 kW across the band with a peak power of more than 600 kW at -3.27 Keywords: Multiple-beam klystron ; MBK; bandwidth GHz. The 1

Picosecond x-ray strain rosette reveals direct laser excitation of coherent transverse acoustic phonons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Sooheyong; Williams, G. Jackson; Campana, Maria I.

Using a strain-rosette, we demonstrate the existence of transverse strain using time-resolved x-ray diffraction from multiple Bragg reflections in laser-excited bulk gallium arsenide. We find that anisotropic strain is responsible for a considerable fraction of the total lattice motion at early times before thermal equilibrium is achieved. Our measurements are described by a new model where the Poisson ratio drives transverse motion, resulting in the creation of shear waves without the need for an indirect process such as mode conversion at an interface. Finally, using the same excitation geometry with the narrow-gap semiconductor indium antimonide, we detected coherent transverse acousticmore » oscillations at frequencies of several GHz.« less

Picosecond x-ray strain rosette reveals direct laser excitation of coherent transverse acoustic phonons

DOE PAGES

Lee, Sooheyong; Williams, G. Jackson; Campana, Maria I.; ...

2016-01-11

Using a strain-rosette, we demonstrate the existence of transverse strain using time-resolved x-ray diffraction from multiple Bragg reflections in laser-excited bulk gallium arsenide. We find that anisotropic strain is responsible for a considerable fraction of the total lattice motion at early times before thermal equilibrium is achieved. Our measurements are described by a new model where the Poisson ratio drives transverse motion, resulting in the creation of shear waves without the need for an indirect process such as mode conversion at an interface. Finally, using the same excitation geometry with the narrow-gap semiconductor indium antimonide, we detected coherent transverse acousticmore » oscillations at frequencies of several GHz.« less

Linear stability analysis of scramjet unstart

NASA Astrophysics Data System (ADS)

Jang, Ik; Nichols, Joseph; Moin, Parviz

2015-11-01

We investigate the bifurcation structure of unstart and restart events in a dual-mode scramjet using the Reynolds-averaged Navier-Stokes equations. The scramjet of interest (HyShot II, Laurence et al., AIAA2011-2310) operates at a free-stream Mach number of approximately 8, and the length of the combustor chamber is 300mm. A heat-release model is applied to mimic the combustion process. Pseudo-arclength continuation with Newton-Raphson iteration is used to calculate multiple solution branches. Stability analysis based on linearized dynamics about the solution curves reveals a metric that optimally forewarns unstart. By combining direct and adjoint eigenmodes, structural sensitivity analysis suggests strategies for unstart mitigation, including changing the isolator length. This work is supported by DOE/NNSA and AFOSR.

On functional determinants of matrix differential operators with multiple zero modes

NASA Astrophysics Data System (ADS)

Falco, G. M.; Fedorenko, Andrei A.; Gruzberg, Ilya A.

2017-12-01

We generalize the method of computing functional determinants with a single excluded zero eigenvalue developed by McKane and Tarlie to differential operators with multiple zero eigenvalues. We derive general formulas for such functional determinants of r× r matrix second order differential operators O with 0 < n ≤slant 2r linearly independent zero modes. We separately discuss the cases of the homogeneous Dirichlet boundary conditions, when the number of zero modes cannot exceed r, and the case of twisted boundary conditions, including the periodic and anti-periodic ones, when the number of zero modes is bounded above by 2r. In all cases the determinants with excluded zero eigenvalues can be expressed only in terms of the n zero modes and other r-n or 2r-n (depending on the boundary conditions) solutions of the homogeneous equation O h=0 , in the spirit of Gel’fand-Yaglom approach. In instanton calculations, the contribution of the zero modes is taken into account by introducing the so-called collective coordinates. We show that there is a remarkable cancellation of a factor (involving scalar products of zero modes) between the Jacobian of the transformation to the collective coordinates and the functional fluctuation determinant with excluded zero eigenvalues. This cancellation drastically simplifies instanton calculations when one uses our formulas.

Quantification of MDL-induced signal degradation in MIMO-OFDM mode-division multiplexing systems.

PubMed

Tian, Yu; Li, Juhao; Zhu, Paikun; Wu, Zhongying; Chen, Yuanxiang; He, Yongqi; Chen, Zhangyuan

2016-08-22

Mode-division multiplexing (MDM) transmission over few-mode optical fiber has emerged as a promising technology to enhance transmission capacity, in which multiple-input-multiple-output (MIMO) digital signal processing (DSP) after coherent detection is used to demultiplex the signals. Compared with conventional single-mode systems, MIMO-MDM systems suffer non-recoverable signal degradation induced by mode-dependent loss (MDL). In this paper, the MDL-induced signal degradation in orthogonal-frequency-division-multiplexing (OFDM) MDM systems is theoretically quantified in terms of mode-average error vector magnitude (EVM) through frequency domain norm analysis. A novel scalar MDL metric is proposed considering the probability distribution of the practical MDM input signals, and a closed-form expression for EVM measured after zero-force (ZF) MIMO equalization is derived. Simulation results show that the EVM estimations utilizing the novel MDL metric remain unbiased for unrepeated links. For a 6 × 100 km 20-mode MDM transmission system, the estimation accuracy is improved by more than 90% compared with that utilizing traditional condition number (CN) based MDL metric. The proposed MDL metric can be used to predict the MDL-induced SNR penalty in a theoretical manner, which will be beneficial for the design of practical MIMO-MDM systems.

Smooth adaptive sliding mode vibration control of a flexible parallel manipulator with multiple smart linkages in modal space

NASA Astrophysics Data System (ADS)

Zhang, Quan; Li, Chaodong; Zhang, Jiantao; Zhang, Jianhui

2017-12-01

This paper addresses the dynamic model and active vibration control of a rigid-flexible parallel manipulator with three smart links actuated by three linear ultrasonic motors. To suppress the vibration of three flexible intermediate links under high speed and acceleration, multiple Lead Zirconium Titanate (PZT) sensors and actuators are collocated mounted on each link, forming a smart structure which can achieve self-sensing and self-actuating. The dynamic characteristics and equations of the flexible link incorporated with the PZT sensors and actuator are analyzed and formulated. The smooth adaptive sliding mode based active vibration control is proposed to suppress the vibration of the smart links, and the first and second modes of the three links are targeted to be suppressed in modal space to avoid the spillover phenomenon. Simulations and experiments are implemented to validate the effectiveness of the smart structures and the proposed control laws. Experimental results show that the vibration of the first mode around 92 Hz and the second mode around 240 Hz of the three smart links are reduced respectively by 64.98%, 59.47%, 62.28%, and 45.80%, 36.79%, 33.33%, which further verify the multi-mode vibration control ability of the smooth adaptive sliding mode control law.

Using Monte Carlo ray tracing simulations to model the quantum harmonic oscillator modes observed in uranium nitride

NASA Astrophysics Data System (ADS)

Lin, J. Y. Y.; Aczel, A. A.; Abernathy, D. L.; Nagler, S. E.; Buyers, W. J. L.; Granroth, G. E.

2014-04-01

Recently an extended series of equally spaced vibrational modes was observed in uranium nitride (UN) by performing neutron spectroscopy measurements using the ARCS and SEQUOIA time-of-flight chopper spectrometers [A. A. Aczel et al., Nat. Commun. 3, 1124 (2012), 10.1038/ncomms2117]. These modes are well described by three-dimensional isotropic quantum harmonic oscillator (QHO) behavior of the nitrogen atoms, but there are additional contributions to the scattering that complicate the measured response. In an effort to better characterize the observed neutron scattering spectrum of UN, we have performed Monte Carlo ray tracing simulations of the ARCS and SEQUOIA experiments with various sample kernels, accounting for nitrogen QHO scattering, contributions that arise from the acoustic portion of the partial phonon density of states, and multiple scattering. These simulations demonstrate that the U and N motions can be treated independently, and show that multiple scattering contributes an approximate Q-independent background to the spectrum at the oscillator mode positions. Temperature-dependent studies of the lowest few oscillator modes have also been made with SEQUOIA, and our simulations indicate that the T dependence of the scattering from these modes is strongly influenced by the uranium lattice.

Reusable Launch Vehicle Control In Multiple Time Scale Sliding Modes

NASA Technical Reports Server (NTRS)

Shtessel, Yuri; Hall, Charles; Jackson, Mark

2000-01-01

A reusable launch vehicle control problem during ascent is addressed via multiple-time scaled continuous sliding mode control. The proposed sliding mode controller utilizes a two-loop structure and provides robust, de-coupled tracking of both orientation angle command profiles and angular rate command profiles in the presence of bounded external disturbances and plant uncertainties. Sliding mode control causes the angular rate and orientation angle tracking error dynamics to be constrained to linear, de-coupled, homogeneous, and vector valued differential equations with desired eigenvalues placement. Overall stability of a two-loop control system is addressed. An optimal control allocation algorithm is designed that allocates torque commands into end-effector deflection commands, which are executed by the actuators. The dual-time scale sliding mode controller was designed for the X-33 technology demonstration sub-orbital launch vehicle in the launch mode. Simulation results show that the designed controller provides robust, accurate, de-coupled tracking of the orientation angle command profiles in presence of external disturbances and vehicle inertia uncertainties. This is a significant advancement in performance over that achieved with linear, gain scheduled control systems currently being used for launch vehicles.

Investigations on Substrate Temperature-Induced Growth Modes of Organic Semiconductors at Dielectric/semiconductor Interface and Their Correlation with Threshold Voltage Stability in Organic Field-Effect Transistors.

PubMed

Padma, Narayanan; Maheshwari, Priya; Bhattacharya, Debarati; Tokas, Raj B; Sen, Shashwati; Honda, Yoshihide; Basu, Saibal; Pujari, Pradeep Kumar; Rao, T V Chandrasekhar

2016-02-10

Influence of substrate temperature on growth modes of copper phthalocyanine (CuPc) thin films at the dielectric/semiconductor interface in organic field effect transistors (OFETs) is investigated. Atomic force microscopy (AFM) imaging at the interface reveals a change from 'layer+island' to "island" growth mode with increasing substrate temperatures, further confirmed by probing the buried interfaces using X-ray reflectivity (XRR) and positron annihilation spectroscopic (PAS) techniques. PAS depth profiling provides insight into the details of molecular ordering while positron lifetime measurements reveal the difference in packing modes of CuPc molecules at the interface. XRR measurements show systematic increase in interface width and electron density correlating well with the change from layer + island to coalesced huge 3D islands at higher substrate temperatures. Study demonstrates the usefulness of XRR and PAS techniques to study growth modes at buried interfaces and reveals the influence of growth modes of semiconductor at the interface on hole and electron trap concentrations individually, thereby affecting hysteresis and threshold voltage stability. Minimum hole trapping is correlated to near layer by layer formation close to the interface at 100 °C and maximum to the island formation with large voids between the grains at 225 °C.

Architecture of GnRH-Gonadotrope-Vasculature Reveals a Dual Mode of Gonadotropin Regulation in Fish.

PubMed

Golan, Matan; Zelinger, Einat; Zohar, Yonathan; Levavi-Sivan, Berta

2015-11-01

The function and components of the hypothalamic-pituitary axis are conserved among vertebrates; however, in fish, a neuroglandular mode of delivery (direct contact between axons and endocrine cells) was considered dominant, whereas in tetrapods hypothalamic signals are relayed to their targets via the hypophysial portal blood system (neurovascular delivery mode). By using a transgenic zebrafish model we studied the functional and anatomical aspects of gonadotrope regulation thus revisiting the existing model. FSH cells were found to be situated close to the vasculature whereas the compact organization of LH cells prevented direct contact of all cells with the circulation. GnRH3 fibers formed multiple boutons upon reaching the pituitary, but most of these structures were located in the neurohypophysis rather than adjacent to gonadotropes. A close association was observed between FSH cells and GnRH3 boutons, but only a fifth of the LH cells were in direct contact with GnRH3 axons, suggesting that FSH cells are more directly regulated than LH cells. GnRH3 fibers closely followed the vasculature in the neurohypophysis and formed numerous boutons along these tracts. These vessels were found to be permeable to relatively large molecules, suggesting the uptake of GnRH3 peptides. Our findings have important implications regarding the differential regulation of LH and FSH and contradict the accepted notion that fish pituitary cells are mostly regulated directly by hypothalamic fibers. Instead, we provide evidence that zebrafish apply a dual mode of gonadotrope regulation by GnRH3 that combines both neuroglandular and neurovascular components.

Modeling and experimental parametric study of a tri-leg compliant orthoplanar spring based multi-mode piezoelectric energy harvester

NASA Astrophysics Data System (ADS)

Dhote, Sharvari; Yang, Zhengbao; Zu, Jean

2018-01-01

This paper presents the modeling and experimental parametric study of a nonlinear multi-frequency broad bandwidth piezoelectric vibration-based energy harvester. The proposed harvester consists of a tri-leg compliant orthoplanar spring (COPS) and multiple masses with piezoelectric plates attached at three different locations. The vibration modes, resonant frequencies, and strain distributions are studied using the finite element analysis. The prototype is manufactured and experimentally investigated to study the effect of single as well as multiple light-weight masses on the bandwidth. The dynamic behavior of the harvester with a mass at the center is modeled numerically and characterized experimentally. The simulation and experimental results are in good agreement. A wide bandwidth with three close nonlinear vibration modes is observed during the experiments when four masses are added to the proposed harvester. The current generator with four masses shows a significant performance improvement with multiple nonlinear peaks under both forward and reverse frequency sweeps.

Comparative Transcriptional Analysis of Asexual and Sexual Morphs Reveals Possible Mechanisms in Reproductive Polyphenism of the Cotton Aphid

PubMed Central

Jiang, Feng; Guo, Wei; Zhou, Shu-Tang

2014-01-01

Aphids, the destructive insect pests in the agriculture, horticulture and forestry, are capable of reproducing asexually and sexually upon environmental change. However, the molecular basis of aphid reproductive mode switch remains an enigma. Here we report a comparative analysis of differential gene expression profiling among parthenogenetic females, gynoparae and sexual females of the cotton aphid Aphis gossypii, using the RNA-seq approach with next-generation sequencing platforms, followed by RT-qPCR. At the cutoff criteria of fold change ≥2 and P<0.01, we identified 741 up- and 879 down-regulated genes in gynoparae versus parthenogenetic females, 2,101 up- and 2,210 down-regulated genes in sexual females compared to gynoparae, and 1,614 up- and 2,238 down-regulated genes in sexual females relative to parthenogenetic females. Gene ontology category and KEGG pathway analysis suggest the involvement of differentially expressed genes in multiple cellular signaling pathways into the reproductive mode transition, including phototransduction, cuticle composition, progesterone-mediated oocyte maturation and endocrine regulation. This study forms a basis for deciphering the molecular mechanisms underlying the shift from asexual to sexual reproduction in the cotton aphid. It also provides valuable resources for future studies on this host-alternating aphid species, and the insight into the understanding of reproductive mode plasticity in different aphid species. PMID:24915491

Subpercent-Scale Control of 3D Low Modes of Targets Imploded in Direct-Drive Configuration on OMEGA

DOE PAGES

Michel, D. T.; Igumenshchev, I. V.; Davis, A. K.; ...

2018-03-23

In a series of direct-drive implosions on OMEGA, multiple time resolved x-ray images were used to tomographically measure their 3-D modes 1, 2, and 3 at a convergence ratio of ~3. Results show that the target modes vary linearly with the laser modes and are not affected by the Rayleigh–Taylor growth or lateral heat transport. This indicates that the residual modes (resulting from physical effects including beam mistiming, mispointing, and laser energy calibration) are approximately constant between shots. Lastly, this demonstrates that the low-mode amplitudes can be mitigated within by adjusting the laser-energy balance to compensate the residual target modes.

Subpercent-Scale Control of 3D Low Modes of Targets Imploded in Direct-Drive Configuration on OMEGA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michel, D. T.; Igumenshchev, I. V.; Davis, A. K.

In a series of direct-drive implosions on OMEGA, multiple time resolved x-ray images were used to tomographically measure their 3-D modes 1, 2, and 3 at a convergence ratio of ~3. Results show that the target modes vary linearly with the laser modes and are not affected by the Rayleigh–Taylor growth or lateral heat transport. This indicates that the residual modes (resulting from physical effects including beam mistiming, mispointing, and laser energy calibration) are approximately constant between shots. Lastly, this demonstrates that the low-mode amplitudes can be mitigated within by adjusting the laser-energy balance to compensate the residual target modes.

Nonlinear dynamics of toroidal Alfvén eigenmodes in presence of tearing modes

NASA Astrophysics Data System (ADS)

Zhu, Jia; Ma, Zhiwei; Wang, Sheng; Zhang, Wei

2016-10-01

A new hybrid kinetic-MHD code CLT-K is developed to study nonlinear dynamics of n =1 toroidal Alfvén eigenmodes (TAEs) with the m/n =2/1 tearing mode. It is found that the n =1 TAE is first excited by isotropic energetic particles in the earlier stage and reaches the steady state due to wave-particle interaction. After the saturation of the n =1 TAE, the tearing mode intervenes and triggers the second growth of the mode. The modes goes into the second steady state due to multiple tearing mode-mode nonlinear coupling. Both wave-particle and wave-wave interactions are observed in our hybrid simulation.

Thermally stable surface-emitting tilted wave laser

NASA Astrophysics Data System (ADS)

Shchukin, V. A.; Ledentsov, N. N.; Kalosha, V. P.; Ledentsov, N.; Agustin, M.; Kropp, J. R.; Maximov, M. V.; Zubov, F. I.; Shernyakov, Yu. M.; Payusov, A. S.; Gordeev, N. Yu; Kulagina, M. M.; Zhukov, A. E.

2018-02-01

Novel lasing modes in a vertical-cavity surface-emitting laser (VCSEL)-type structure based on an antiwaveguding cavity are studied. Such a VCSEL cavity has an effective refractive index in the cavity region lower than the average index of the distributed Bragg reflectors (DBRs). Such device in a stripe geometry does not support in-plane waveguiding mode, and all modes with a high Q-factor are exclusively VCSEL-like modes with similar near field profile in the vertical direction. A GaAlAs-based VCSEL structure studied contains a resonant cavity with multiple GaInAs quantum wells as an active region. The VCSEL structure is processed as an edge-emitting laser with cleaved facets and top contact representing a non-alloyed metal grid. Rectangular-shaped 400x400 µm pieces are cleaved with perpendicular facets. The contact grid region has a total width of 70 μm. 7 μm-wide metal stripes serve as non-alloyed metal contact and form periodic rectangular openings having a size of 10x40 μm. Surface emission through the windows on top of the chip is measured at temperatures from 90 to 380 K. Three different types of modes are observed. The longest wavelength mode (mode A) is a VCSEL-like mode at 854 nm emitting normal to the surface with a full width at half maximum (FWHM) of the far field 10°. Accordingly the lasing wavelength demonstrates a thermal shift of the wavelength of 0.06 nm/K. Mode B is at shorter wavelengths of 840 nm at room temperature, emitting light at two symmetric lobes at tilt angles 40° with respect to the normal to the surface in the directions parallel to the stripe. The emission wavelength of this mode shifts at a rate 0.22 nm/K according to the GaAs bandgap shift. The angle of mode B with respect to the normal reduces as the wavelength approaches the vertical cavity etalon wavelength and this mode finally merges with the VCSEL mode. Mode B hops between different lateral modes of the VCSEL forming a dense spectrum due to significant longitudinal cavity length, and the thermal shift of its wavelength is governed by the shift of the gain spectrum. The most interesting observation is Mode C, which shifts at a rate 0.06 nm/K and has a spectral width of 1 nm. Mode C matches the wavelength of the critical angle for total internal reflection for light impinging from semiconductor chip on semiconductor/air interface and propagates essentially as an in-plane mode. According to modeling data we conclude that the lasing mode represents a coupled state between the TM-polarized surface-trapped optical mode and the VCSEL cavity mode. The resulting mode has an extended near field zone and low propagation losses. The intensity of the mode drastically enhances once is appears at resonance with Mode B. A clear threshold is revealed in the L-I curves of all modes and there is a strong competition of the lasing mechanisms once the gain maximum is scanned over the related wavelength range by temperature change.

Spray deposition inside multiple-row nursery trees with a laser-guided sprayer

USDA-ARS?s Scientific Manuscript database

Multiple-row container-grown trees require specially designed sprayers to achieve efficient spray delivery quality. A five-port air-assisted sprayer with both automatic and manual control modes was developed to discharge adequate spray deposition inside multiple-row tree plants. The sprayer resulted...

Viscous driving of global oscillations in accretion discs around black holes

NASA Astrophysics Data System (ADS)

Miranda, Ryan; Horák, Jiří; Lai, Dong

2015-01-01

We examine the role played by viscosity in the excitation of global oscillation modes (both axisymmetric and non-axisymmetric) in accretion discs around black holes using two-dimensional hydrodynamic simulations. The turbulent viscosity is modelled by the α-ansatz, with different equations of state. We consider both discs with transonic radial inflows across the innermost stable circular orbit, and stationary discs truncated by a reflecting wall at their inner edge, representing a magnetosphere. In transonic discs, viscosity can excite several types of global oscillation modes. These modes are either axisymmetric with frequencies close to multiples of the maximum radial epicyclic frequency κmax, non-axisymmetric with frequencies close to multiples of the innermost stable orbit frequency ΩISCO, or hybrid modes whose frequencies are linear combinations of these two frequencies. Small values of the viscosity parameter α primarily produce non-axisymmetric modes, while axisymmetric modes become dominant for large α. The excitation of these modes may be related to an instability of the sonic point, at which the radial infall speed is equal to the sound speed of the gas. In discs with a reflective inner boundary, we explore the effect of viscosity on trapped p modes which are intrinsically overstable due to the corotation resonance effect. The effect of viscosity is either to reduce the growth rates of these modes, or to completely suppress them and excite a new class of higher frequency modes. The latter requires that the dynamic viscosity scales positively with the disc surface density, indicating that it is a result of the classic viscous overstability effect.

Theoretical and experimental investigation of multispectral photoacoustic osteoporosis detection method

NASA Astrophysics Data System (ADS)

Steinberg, Idan; Hershkovich, Hadas Sara; Gannot, Israel; Eyal, Avishay

2014-03-01

Osteoporosis is a widespread disorder, which has a catastrophic impact on patients lives and overwhelming related to healthcare costs. Recently, we proposed a multispectral photoacoustic technique for early detection of osteoporosis. Such technique has great advantages over pure ultrasonic or optical methods as it allows the deduction of both bone functionality from the bone absorption spectrum and bone resistance to fracture from the characteristics of the ultrasound propagation. We demonstrated the propagation of multiple acoustic modes in animal bones in-vitro. To further investigate the effects of multiple wavelength excitations and of induced osteoporosis on the PA signal a multispectral photoacoustic system is presented. The experimental investigation is based on measuring the interference of multiple acoustic modes. The performance of the system is evaluated and a simple two mode theoretical model is fitted to the measured phase signals. The results show that such PA technique is accurate and repeatable. Then a multiple wavelength excitation is tested. It is shown that the PA response due to different excitation wavelengths revels that absorption by the different bone constitutes has a profound effect on the mode generation. The PA response is measured in single wavelength before and after induced osteoporosis. Results show that induced osteoporosis alters the measured amplitude and phase in a consistent manner which allows the detection of the onset of osteoporosis. These results suggest that a complete characterization of the bone over a region of both acoustic and optical frequencies might be used as a powerful tool for in-vivo bone evaluation.

Engineered circuit QED with dense resonant modes

NASA Astrophysics Data System (ADS)

Wilhelm, Frank; Egger, Daniel

2013-03-01

In circuit quantum electrodynamics even in the ultrastrong coupling regime, strong quasi-resonant interaction typically involves only one mode of the resonator as the mode spacing is comparable to the frequency of the mode. We are going to present an engineered hybrid transmission line consisting of a left-handed and a right-handed portion that has a low-frequency van-Hove singularity hence showing a dense mode spectrum at an experimentally accessible point. This gives rise to strong multi-mode coupling and can be utilized in multiple ways to create strongly correlated microwave photons. Supported by DARPA through the QuEST program and by NSERC Discovery grants

Multiple injection mode with or without repeated sample injections: Strategies to enhance productivity in countercurrent chromatography.

PubMed

Müller, Marco; Wasmer, Katharina; Vetter, Walter

2018-06-29

Countercurrent chromatography (CCC) is an all liquid based separation technique typically used for the isolation and purification of natural compounds. The simplicity of the method makes it easy to scale up CCC separations from analytical to preparative and even industrial scale. However, scale-up of CCC separations requires two different instruments with varying coil dimensions. Here we developed two variants of the CCC multiple injection mode as an alternative to increase the throughput and enhance productivity of a CCC separation when using only one instrument. The concept is based on the parallel injection of samples at different points in the CCC column system and the simultaneous separation using one pump only. The wiring of the CCC setup was modified by the insertion of a 6-port selection valve, multiple T-pieces and sample loops. Furthermore, the introduction of storage sample loops enabled the CCC system to be used with repeated injection cycles. Setup and advantages of both multiple injection modes were shown by the isolation of the furan fatty acid 11-(3,4-dimethyl-5-pentylfuran-2-yl)-undecanoic acid (11D5-EE) from an ethyl ester oil rich in 4,7,10,13,16,19-docosahexaenoic acid (DHA-EE). 11D5-EE was enriched in one step from 1.9% to 99% purity. The solvent consumption per isolated amount of analyte could be reduced by ∼40% compared to increased throughput CCC and by ∼5% in the repeated multiple injection mode which also facilitated the isolation of the major compound (DHA-EE) in the sample. Copyright © 2018 Elsevier B.V. All rights reserved.

Current profile redistribution driven by neutral beam injection in a reversed-field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parke, E.; Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706; Anderson, J. K.

2016-05-15

Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm withmore » neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q{sub 0} by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].« less

Causality analysis of leading singular value decomposition modes identifies rotor as the dominant driving normal mode in fibrillation

NASA Astrophysics Data System (ADS)

Biton, Yaacov; Rabinovitch, Avinoam; Braunstein, Doron; Aviram, Ira; Campbell, Katherine; Mironov, Sergey; Herron, Todd; Jalife, José; Berenfeld, Omer

2018-01-01

Cardiac fibrillation is a major clinical and societal burden. Rotors may drive fibrillation in many cases, but their role and patterns are often masked by complex propagation. We used Singular Value Decomposition (SVD), which ranks patterns of activation hierarchically, together with Wiener-Granger causality analysis (WGCA), which analyses direction of information among observations, to investigate the role of rotors in cardiac fibrillation. We hypothesized that combining SVD analysis with WGCA should reveal whether rotor activity is the dominant driving force of fibrillation even in cases of high complexity. Optical mapping experiments were conducted in neonatal rat cardiomyocyte monolayers (diameter, 35 mm), which were genetically modified to overexpress the delayed rectifier K+ channel IKr only in one half of the monolayer. Such monolayers have been shown previously to sustain fast rotors confined to the IKr overexpressing half and driving fibrillatory-like activity in the other half. SVD analysis of the optical mapping movies revealed a hierarchical pattern in which the primary modes corresponded to rotor activity in the IKr overexpressing region and the secondary modes corresponded to fibrillatory activity elsewhere. We then applied WGCA to evaluate the directionality of influence between modes in the entire monolayer using clear and noisy movies of activity. We demonstrated that the rotor modes influence the secondary fibrillatory modes, but influence was detected also in the opposite direction. To more specifically delineate the role of the rotor in fibrillation, we decomposed separately the respective SVD modes of the rotor and fibrillatory domains. In this case, WGCA yielded more information from the rotor to the fibrillatory domains than in the opposite direction. In conclusion, SVD analysis reveals that rotors can be the dominant modes of an experimental model of fibrillation. Wiener-Granger causality on modes of the rotor domains confirms their preferential driving influence on fibrillatory modes.

The impacts of freight mode splitting on congestion, risk, and delivery reliability.

DOT National Transportation Integrated Search

2012-09-01

Although splitting shipments across multiple delivery or transportation modes typically : increases total shipping costs as a result of diseconomies of scale, it may offer certain benefits : that can more than offset these costs. These benefits inclu...

An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

PubMed Central

Shafqat-Abbasi, Hamdah; Kowalewski, Jacob M; Kiss, Alexa; Gong, Xiaowei; Hernandez-Varas, Pablo; Berge, Ulrich; Jafari-Mamaghani, Mehrdad; Lock, John G; Strömblad, Staffan

2016-01-01

Mesenchymal (lamellipodial) migration is heterogeneous, although whether this reflects progressive variability or discrete, 'switchable' migration modalities, remains unclear. We present an analytical toolbox, based on quantitative single-cell imaging data, to interrogate this heterogeneity. Integrating supervised behavioral classification with multivariate analyses of cell motion, membrane dynamics, cell-matrix adhesion status and F-actin organization, this toolbox here enables the detection and characterization of two quantitatively distinct mesenchymal migration modes, termed 'Continuous' and 'Discontinuous'. Quantitative mode comparisons reveal differences in cell motion, spatiotemporal coordination of membrane protrusion/retraction, and how cells within each mode reorganize with changed cell speed. These modes thus represent distinctive migratory strategies. Additional analyses illuminate the macromolecular- and cellular-scale effects of molecular targeting (fibronectin, talin, ROCK), including 'adaptive switching' between Continuous (favored at high adhesion/full contraction) and Discontinuous (low adhesion/inhibited contraction) modes. Overall, this analytical toolbox now facilitates the exploration of both spontaneous and adaptive heterogeneity in mesenchymal migration. DOI: http://dx.doi.org/10.7554/eLife.11384.001 PMID:26821527

Optical Fibers Would Sense Local Strains

NASA Technical Reports Server (NTRS)

Egalon, Claudio O.; Rogowski, Robert S.

1994-01-01

Proposed fiber-optic transducers measure local strains. Includes lead-in and lead-out lengths producing no changes in phase shifts, plus short sensing length in which phase shift is sensitive to strain. Phase shifts in single-mode fibers vary with strains. In alternative version, multiple portions of optical fiber sensitive to strains characteristic of specific vibrational mode of object. Same principle also used with two-mode fiber.

The CHIC Model: A Global Model for Coupled Binary Data

ERIC Educational Resources Information Center

Wilderjans, Tom; Ceulemans, Eva; Van Mechelen, Iven

2008-01-01

Often problems result in the collection of coupled data, which consist of different N-way N-mode data blocks that have one or more modes in common. To reveal the structure underlying such data, an integrated modeling strategy, with a single set of parameters for the common mode(s), that is estimated based on the information in all data blocks, may…

Inelastic neutron scattering experiments with the monochromatic imaging mode of the RITA-II spectrometer

NASA Astrophysics Data System (ADS)

Bahl, C. R. H.; Lefmann, K.; Abrahamsen, A. B.; Rønnow, H. M.; Saxild, F.; Jensen, T. B. S.; Udby, L.; Andersen, N. H.; Christensen, N. B.; Jakobsen, H. S.; Larsen, T.; Häfliger, P. S.; Streule, S.; Niedermayer, Ch.

2006-05-01

Recently a monochromatic multiple data taking mode has been demonstrated for diffraction experiments using a RITA type cold neutron spectrometer with a multi-bladed analyser and a position-sensitive detector. Here, we show how this mode can be used in combination with a flexible radial collimator to perform real inelastic neutron scattering experiments. We present the results from inelastic powder, single crystal dispersion and single crystal constant energy mapping experiments. The advantages and complications of performing these experiments are discussed along with a comparison between the imaging mode and the traditional monochromatic focussing mode.

Update on Linear Mode Photon Counting with the HgCdTe Linear Mode Avalanche Photodiode

NASA Technical Reports Server (NTRS)

Beck, Jeffrey D.; Kinch, Mike; Sun, Xiaoli

2014-01-01

The behavior of the gain-voltage characteristic of the mid-wavelength infrared cutoff HgCdTe linear mode avalanche photodiode (e-APD) is discussed both experimentally and theoretically as a function of the width of the multiplication region. Data are shown that demonstrate a strong dependence of the gain at a given bias voltage on the width of the n- gain region. Geometrical and fundamental theoretical models are examined to explain this behavior. The geometrical model takes into account the gain-dependent optical fill factor of the cylindrical APD. The theoretical model is based on the ballistic ionization model being developed for the HgCdTe APD. It is concluded that the fundamental theoretical explanation is the dominant effect. A model is developed that combines both the geometrical and fundamental effects. The model also takes into account the effect of the varying multiplication width in the low bias region of the gain-voltage curve. It is concluded that the lower than expected gain seen in the first 2 × 8 HgCdTe linear mode photon counting APD arrays, and higher excess noise factor, was very likely due to the larger than typical multiplication region length in the photon counting APD pixel design. The implications of these effects on device photon counting performance are discussed.

Multi-Mode Estimation for Small Fixed Wing Unmanned Aerial Vehicle Localization Based on a Linear Matrix Inequality Approach

PubMed Central

Elzoghby, Mostafa; Li, Fu; Arafa, Ibrahim. I.; Arif, Usman

2017-01-01

Information fusion from multiple sensors ensures the accuracy and robustness of a navigation system, especially in the absence of global positioning system (GPS) data which gets degraded in many cases. A way to deal with multi-mode estimation for a small fixed wing unmanned aerial vehicle (UAV) localization framework is proposed, which depends on utilizing a Luenberger observer-based linear matrix inequality (LMI) approach. The proposed estimation technique relies on the interaction between multiple measurement modes and a continuous observer. The state estimation is performed in a switching environment between multiple active sensors to exploit the available information as much as possible, especially in GPS-denied environments. Luenberger observer-based projection is implemented as a continuous observer to optimize the estimation performance. The observer gain might be chosen by solving a Lyapunov equation by means of a LMI algorithm. Convergence is achieved by utilizing the linear matrix inequality (LMI), based on Lyapunov stability which keeps the dynamic estimation error bounded by selecting the observer gain matrix (L). Simulation results are presented for a small UAV fixed wing localization problem. The results obtained using the proposed approach are compared with a single mode Extended Kalman Filter (EKF). Simulation results are presented to demonstrate the viability of the proposed strategy. PMID:28420214

Rogue waves generation via nonlinear soliton collision in multiple-soliton state of a mode-locked fiber laser.

PubMed

Peng, Junsong; Tarasov, Nikita; Sugavanam, Srikanth; Churkin, Dmitry

2016-09-19

We report for the first time, rogue waves generation in a mode-locked fiber laser that worked in multiple-soliton state in which hundreds of solitons occupied the whole laser cavity. Using real-time spatio-temporal intensity dynamics measurements, it is unveiled that nonlinear soliton collision accounts for the formation of rogue waves in this laser state. The nature of interactions between solitons are also discussed. Our observation may suggest similar formation mechanisms of rogue waves in other systems.

Discovery of multiple, ionization-created CS{sub 2} anions and a new mode of operation for drift chambers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snowden-Ifft, Daniel P.

2014-01-15

This paper focuses on the surprising discovery of multiple species of ionization-created CS{sub 2} anions in gas mixtures containing electronegative CS{sub 2} and O{sub 2}, identified by their slightly different drift velocities. Data are presented to understand the formation mechanism and identity of these new anions. Regardless of the micro-physics, however, this discovery offers a new, trigger-less mode of operation for the drift chambers. A demonstration of trigger-less operation is presented.

Generation of double giant pulses in actively Q-switched lasers

NASA Astrophysics Data System (ADS)

Korobeynikova, A. P.; Shaikin, I. A.; Shaykin, A. A.; Koryukin, I. V.; Khazanov, E. A.

2018-04-01

Generation of a second giant pulse in a longitudinal mode neighbouring to the longitudinal mode possessing minimal losses is theoretically and experimentally studied in actively Q-switched lasers. A mathematical model is suggested for explaining the giant pulse generation in a laser with multiple longitudinal modes. The model makes allowance for not only a standing, but also a running wave for each cavity mode. Results of numerical simulation and data of experiments with a Nd : YLF laser explain the effect of second giant pulse generation in a neighbouring longitudinal mode. After a giant pulse in the mode with minimal losses is generated, the threshold for the neighbouring longitudinal mode is still exceeded due to the effect of burning holes in the population inversion spatial distribution.

Influence of driving frequency on discharge modes in a dielectric-barrier discharge with multiple current pulses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiang, Weiman; Tang, Jie; Wang, Yishan

2013-07-15

A one-dimensional self-consistent fluid model was employed to investigate the effect of the driving frequency on the discharge modes in atmospheric-pressure argon discharge with multiple current pulses. The discharge mode was discussed in detail not only at current peaks but also between two adjacent peaks. The simulation results show that different transitions between the Townsend and glow modes during the discharge take place with the driving frequency increased. A complicated transition from the Townsend mode, through glow, Townsend, and glow, and finally back to the Townsend one is found in the discharge with the driving frequency of 8 kHz. Theremore » is a tendency of transition from the Townsend to glow mode for the discharge both at the current peaks and troughs with the increasing frequency. The discharge in the half period can all along operate in the glow mode with the driving frequency high enough. This is resulted from the preservation of more electrons in the gas gap and acquisition of more electron energy from the swiftly varying electric field with the increase in driving frequency. Comparison of the spatial and temporal evolutions of the electron density at different driving frequencies indicates that the increment of the driving frequency allows the plasma chemistry to be enhanced. This electrical characteristic is important for the applications, such as surface treatment and biomedical sterilization.« less

Multi-mode application of graphene quantum dots bonded silica stationary phase for high performance liquid chromatography.

PubMed

Wu, Qi; Sun, Yaming; Zhang, Xiaoli; Zhang, Xia; Dong, Shuqing; Qiu, Hongdeng; Wang, Litao; Zhao, Liang

2017-04-07

Graphene quantum dots (GQDs), which possess hydrophobic, hydrophilic, π-π stacking and hydrogen bonding properties, have great prospect in HPLC. In this study, a novel GQDs bonded silica stationary phase was prepared and applied in multiple separation modes including normal phase, reversed phase and hydrophilic chromatography mode. Alkaloids, nucleosides and nucleobases were chosen as test compounds to evaluate the separation performance of this column in hydrophilic chromatographic mode. The tested polar compounds achieved baseline separation and the resolutions reached 2.32, 4.62, 7.79, 1.68 for thymidine, uridine, adenosine, cytidine and guanosine. This new column showed satisfactory chromatographic performance for anilines, phenols and polycyclic aromatic hydrocarbons in normal and reversed phase mode. Five anilines were completely separated within 10min under the condition of mobile phase containing only 10% methanol. The effect of water content, buffer concentration and pH on chromatographic separation was further investigated, founding that this new stationary phase showed a complex retention mechanism of partitioning, adsorption and electrostatic interaction in hydrophilic chromatography mode, and the multiple retention interactions such as π-π stacking and π-π electron-donor-acceptor interaction played an important role during the separation process. This GQDs bonded column, which allows us to adjust appropriate chromatography mode according to the properties of analytes, has possibility in actual application after further research. Copyright © 2017 Elsevier B.V. All rights reserved.

Modeling and performance metrics of MIMO-SDM systems with different amplification schemes in the presence of mode-dependent loss.

PubMed

Antonelli, Cristian; Mecozzi, Antonio; Shtaif, Mark; Winzer, Peter J

2015-02-09

Mode-dependent loss (MDL) is a major factor limiting the achievable information rate in multiple-input multiple-output space-division multiplexed systems. In this paper we show that its impact on system performance, which we quantify in terms of the capacity reduction relative to a reference MDL-free system, may depend strongly on the operation of the inline optical amplifiers. This dependency is particularly strong in low mode-count systems. In addition, we discuss ways in which the signal-to-noise ratio of the MDL-free reference system can be defined and quantify the differences in the predicted capacity loss. Finally, we stress the importance of correctly accounting for the effect of MDL on the accumulation of amplification noise.

Effects of auditory and visual modalities in recall of words.

PubMed

Gadzella, B M; Whitehead, D A

1975-02-01

Ten experimental conditions were used to study the effects of auditory and visual (printed words, uncolored and colored pictures) modalities and their various combinations with college students. A recall paradigm was employed in which subjects responded in a written test. Analysis of data showed the auditory modality was superior to visual (pictures) ones but was not significantly different from visual (printed words) modality. In visual modalities, printed words were superior to colored pictures. Generally, conditions with multiple modes of representation of stimuli were significantly higher than for conditions with single modes. Multiple modalities, consisting of two or three modes, did not differ significantly from each other. It was concluded that any two modalities of the stimuli presented simultaneously were just as effective as three in recall of stimulus words.

Time-Frequency Analysis of the Dispersion of Lamb Modes

NASA Technical Reports Server (NTRS)

Prosser, W. H.; Seale, Michael D.; Smith, Barry T.

1999-01-01

Accurate knowledge of the velocity dispersion of Lamb modes is important for ultrasonic nondestructive evaluation methods used in detecting and locating flaws in thin plates and in determining their elastic stiffness coefficients. Lamb mode dispersion is also important in the acoustic emission technique for accurately triangulating the location of emissions in thin plates. In this research, the ability to characterize Lamb mode dispersion through a time-frequency analysis (the pseudo-Wigner-Ville distribution) was demonstrated. A major advantage of time-frequency methods is the ability to analyze acoustic signals containing multiple propagation modes, which overlap and superimpose in the time domain signal. By combining time-frequency analysis with a broadband acoustic excitation source, the dispersion of multiple Lamb modes over a wide frequency range can be determined from as little as a single measurement. In addition, the technique provides a direct measurement of the group velocity dispersion. The technique was first demonstrated in the analysis of a simulated waveform in an aluminum plate in which the Lamb mode dispersion was well known. Portions of the dispersion curves of the AO, A I , So, and S2 Lamb modes were obtained from this one waveform. The technique was also applied for the analysis of experimental waveforms from a unidirectional graphite/epoxy composite plate. Measurements were made both along and perpendicular to the fiber direction. In this case, the signals contained only the lowest order symmetric and antisymmetric modes. A least squares fit of the results from several source to detector distances was used. Theoretical dispersion curves were calculated and are shown to be in good agreement with experimental results.

Subpulse drifting, nulling, and mode changing in PSR J1822-2256

NASA Astrophysics Data System (ADS)

Basu, Rahul; Mitra, Dipanjan

2018-05-01

We report a detailed observational study of the single pulses from the pulsar J1822-2256. The pulsar shows the presence of subpulse drifting, nulling as well as multiple emission modes. During these observations the pulsar existed primarily in two modes; mode A with prominent drift bands and mode B which was more disorderly without any clear subpulse drifting. A third mode C was also seen for a short duration with a different drifting periodicity compared to mode A. The nulls were present throughout the observations but were more frequent during the disorderly B mode. The nulling also exhibited periodicity with a clear peak in the fluctuation spectra. Before the transition from mode A to nulling the pulsar switched to a third drifting state with periodicity different from both mode A and C. The diversity seen in the single pulse behaviour from the pulsar J1822-2256 provides an unique window into the emission physics.

Service offerings and interfaces for the ACTS network of Earth stations

NASA Technical Reports Server (NTRS)

Coney, Thom A.

1988-01-01

The Advanced Communications Satellite (ACTS) is capable of two modes of communication. Mode 1 is a mesh network of Earth stations using baseband-switched, time-division multiple-access (BBS-TDMA) and hopping beams. Mode 2 is a mesh network using satellite-switched, time-division multiple-access (SS-TDMA) and fixed (or hopping) beams. The purpose of this paper is to present the functional requirements and the design of the ACTS Mode 1 Earth station terrestrial interface. Included among the requirements are that: (1) the interface support standard telecommunications service offerings (i.e., voice, video and data at rates ranging from 9.6 kbps to 44 Mbps); (2) the interface support the unique design characteristics of the ACTS communications systems (e.g., the real time demand assignment of satellite capacity); and (3) the interface support test hardware capable of validating ACTS communications processes. The resulting interface design makes use of an appropriate combination of T1 or T3 multiplexers and a small central office (maximum capacity 56 subscriber lines per unit).

Assessment of body mapping sportswear using a manikin operated in constant temperature mode and thermoregulatory model control mode

NASA Astrophysics Data System (ADS)

Wang, Faming; Del Ferraro, Simona; Molinaro, Vincenzo; Morrissey, Matthew; Rossi, René

2014-09-01

Regional sweating patterns and body surface temperature differences exist between genders. Traditional sportswear made from one material and/or one fabric structure has a limited ability to provide athletes sufficient local wear comfort. Body mapping sportswear consists of one piece of multiple knit structure fabric or of different fabric pieces that may provide athletes better wear comfort. In this study, the `modular' body mapping sportswear was designed and subsequently assessed on a `Newton' type sweating manikin that operated in both constant temperature mode and thermophysiological model control mode. The performance of the modular body mapping sportswear kit and commercial products were also compared. The results demonstrated that such a modular body mapping sportswear kit can meet multiple wear/thermal comfort requirements in various environmental conditions. All body mapping clothing (BMC) presented limited global thermophysiological benefits for the wearers. Nevertheless, BMC showed evident improvements in adjusting local body heat exchanges and local thermal sensations.

Assessment of body mapping sportswear using a manikin operated in constant temperature mode and thermoregulatory model control mode.

PubMed

Wang, Faming; Del Ferraro, Simona; Molinaro, Vincenzo; Morrissey, Matthew; Rossi, René

2014-09-01

Regional sweating patterns and body surface temperature differences exist between genders. Traditional sportswear made from one material and/or one fabric structure has a limited ability to provide athletes sufficient local wear comfort. Body mapping sportswear consists of one piece of multiple knit structure fabric or of different fabric pieces that may provide athletes better wear comfort. In this study, the 'modular' body mapping sportswear was designed and subsequently assessed on a 'Newton' type sweating manikin that operated in both constant temperature mode and thermophysiological model control mode. The performance of the modular body mapping sportswear kit and commercial products were also compared. The results demonstrated that such a modular body mapping sportswear kit can meet multiple wear/thermal comfort requirements in various environmental conditions. All body mapping clothing (BMC) presented limited global thermophysiological benefits for the wearers. Nevertheless, BMC showed evident improvements in adjusting local body heat exchanges and local thermal sensations.

Integrated cladding-pumped multicore few-mode erbium-doped fibre amplifier for space-division-multiplexed communications

NASA Astrophysics Data System (ADS)

Chen, H.; Jin, C.; Huang, B.; Fontaine, N. K.; Ryf, R.; Shang, K.; Grégoire, N.; Morency, S.; Essiambre, R.-J.; Li, G.; Messaddeq, Y.; Larochelle, S.

2016-08-01

Space-division multiplexing (SDM), whereby multiple spatial channels in multimode and multicore optical fibres are used to increase the total transmission capacity per fibre, is being investigated to avert a data capacity crunch and reduce the cost per transmitted bit. With the number of channels employed in SDM transmission experiments continuing to rise, there is a requirement for integrated SDM components that are scalable. Here, we demonstrate a cladding-pumped SDM erbium-doped fibre amplifier (EDFA) that consists of six uncoupled multimode erbium-doped cores. Each core supports three spatial modes, which enables the EDFA to amplify a total of 18 spatial channels (six cores × three modes) simultaneously with a single pump diode and a complexity similar to a single-mode EDFA. The amplifier delivers >20 dBm total output power per core and <7 dB noise figure over the C-band. This cladding-pumped EDFA enables combined space-division and wavelength-division multiplexed transmission over multiple multimode fibre spans.

Liquid detection with InGaAsP semiconductor lasers having multiple short external cavities.

PubMed

Zhu, X; Cassidy, D T

1996-08-20

A liquid detection system consisting of a diode laser with multiple short external cavities (MSXC's) is reported. The MSXC diode laser operates single mode on one of 18 distinct modes that span a range of 72 nm. We selected the modes by setting the length of one of the external cavities using a piezoelectric positioner. One can measure the transmission through cells by modulating the injection current at audio frequencies and using phase-sensitive detection to reject the ambient light and reduce 1/f noise. A method to determine regions of single-mode operation by the rms of the output of the laser is described. The transmission data were processed by multivariate calibration techniques, i.e., partial least squares and principal component regression. Water concentration in acetone was used to demonstrate the performance of the system. A correlation coefficient of R(2) = 0.997 and 0.29% root-mean-square error of prediction are found for water concentration over the range of 2-19%.

Formal Derivation of Lotka-Volterra-Haken Amplitude Equations of Task-Related Brain Activity in Multiple, Consecutively Performed Tasks

NASA Astrophysics Data System (ADS)

Frank, T. D.

The Lotka-Volterra-Haken equations have been frequently used in ecology and pattern formation. Recently, the equations have been proposed by several research groups as amplitude equations for task-related patterns of brain activity. In this theoretical study, the focus is on the circular causality aspect of pattern formation systems as formulated within the framework of synergetics. Accordingly, the stable modes of a pattern formation system inhibit the unstable modes, whereas the unstable modes excite the stable modes. Using this circular causality principle it is shown that under certain conditions the Lotka-Volterra-Haken amplitude equations can be derived from a general model of brain activity akin to the Wilson-Cowan model. The model captures the amplitude dynamics for brain activity patterns in experiments involving several consecutively performed multiple-choice tasks. This is explicitly demonstrated for two-choice tasks involving grasping and walking. A comment on the relevance of the theoretical framework for clinical psychology and schizophrenia is given as well.

A nonlinear multi-mode wideband piezoelectric vibration-based energy harvester using compliant orthoplanar spring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dhote, Sharvari, E-mail: sharvari.dhote@mail.utoronto.ca; Zu, Jean; Zhu, Yang

2015-04-20

In this paper, a nonlinear wideband multi-mode piezoelectric vibration-based energy harvester (PVEH) is proposed based on a compliant orthoplanar spring (COPS), which has an advantage of providing multiple vibration modes at relatively low frequencies. The PVEH is made of a tri-leg COPS flexible structure, where three fixed-guided beams are capable of generating strong nonlinear oscillations under certain base excitation. A prototype harvester was fabricated and investigated through both finite-element analysis and experiments. The frequency response shows multiple resonance which corresponds to a hardening type of nonlinear resonance. By adding masses at different locations on the COPS structure, the first threemore » vibration modes are brought close to each other, where the three hardening nonlinear resonances provide a wide bandwidth for the PVEH. The proposed PVEH has enhanced performance of the energy harvester in terms of a wide frequency bandwidth and a high-voltage output under base excitations.« less

Energy-aware embedded classifier design for real-time emotion analysis.

PubMed

Padmanabhan, Manoj; Murali, Srinivasan; Rincon, Francisco; Atienza, David

2015-01-01

Detection and classification of human emotions from multiple bio-signals has a wide variety of applications. Though electronic devices are available in the market today that acquire multiple body signals, the classification of human emotions in real-time, adapted to the tight energy budgets of wearable embedded systems is a big challenge. In this paper we present an embedded classifier for real-time emotion classification. We propose a system that operates at different energy budgeted modes, depending on the available energy, where each mode is constrained by an operating energy bound. The classifier has an offline training phase where feature selection is performed for each operating mode, with an energy-budget aware algorithm that we propose. Across the different operating modes, the classification accuracy ranges from 95% - 75% and 89% - 70% for arousal and valence respectively. The accuracy is traded off for less power consumption, which results in an increased battery life of up to 7.7 times (from 146.1 to 1126.9 hours).

Methods and circuitry for reconfigurable SEU/SET tolerance

NASA Technical Reports Server (NTRS)

Shuler, Jr., Robert L. (Inventor)

2010-01-01

A device is disclosed in one embodiment that has multiple identical sets of programmable functional elements, programmable routing resources, and majority voters that correct errors. The voters accept a mode input for a redundancy mode and a split mode. In the redundancy mode, the programmable functional elements are identical and are programmed identically so the voters produce an output corresponding to the majority of inputs that agree. In a split mode, each voter selects a particular programmable functional element output as the output of the voter. Therefore, in the split mode, the programmable functional elements can perform different functions, operate independently, and/or be connected together to process different parts of the same problem.

Using Monte Carlo ray tracing simulations to model the quantum harmonic oscillator modes observed in uranium nitride

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, J. Y. Y.; Aczel, Adam A; Abernathy, Douglas L

2014-01-01

Recently an extended series of equally spaced vibrational modes was observed in uranium nitride (UN) by performing neutron spectroscopy measurements using the ARCS and SEQUOIA time-of- flight chopper spectrometers [A.A. Aczel et al, Nature Communications 3, 1124 (2012)]. These modes are well described by 3D isotropic quantum harmonic oscillator (QHO) behavior of the nitrogen atoms, but there are additional contributions to the scattering that complicate the measured response. In an effort to better characterize the observed neutron scattering spectrum of UN, we have performed Monte Carlo ray tracing simulations of the ARCS and SEQUOIA experiments with various sample kernels, accountingmore » for the nitrogen QHO scattering, contributions that arise from the acoustic portion of the partial phonon density of states (PDOS), and multiple scattering. These simulations demonstrate that the U and N motions can be treated independently, and show that multiple scattering contributes an approximate Q-independent background to the spectrum at the oscillator mode positions. Temperature dependent studies of the lowest few oscillator modes have also been made with SEQUOIA, and our simulations indicate that the T-dependence of the scattering from these modes is strongly influenced by the uranium lattice.« less

Localized surface plasmon resonance properties of symmetry-broken Au-ITO-Ag multilayered nanoshells

NASA Astrophysics Data System (ADS)

Lv, Jingwei; Mu, Haiwei; Lu, Xili; Liu, Qiang; Liu, Chao; Sun, Tao; Chu, Paul K.

2018-06-01

The plasmonic properties of symmetry-broken Au-ITO-Ag multilayered nanoshells by shell cutting are studied by the finite element method. The influence of the polarization of incident light and geometrical parameters on the plasmon resonances of the multilayered nanoshells are investigated. The polarization-dependent multiple plasmon resonances appear from the multilayered nanoshells due to symmetry breaking. In nanostructures with a broken symmetry, the localized surface plasmon resonance modes are enhanced resulting in higher order resonances. According to the plasmon hybridization theory, these resonance modes and greater spectral tunability derive from the interactions of an admixture of both primitive and multipolar modes between the inner Au core and outer Ag shell. By changing the radius of the Au core, the extinction resonance modes of the multilayered nanoshells can be easily tuned to the near-infrared region. To elucidate the symmetry-broken effects of multilayered nanoshells, we link the geometrical asymmetry to the asymmetrical distributions of surface charges and demonstrate dipolar and higher order plasmon modes with large associated field enhancements at the edge of the Ag rim. The spectral tunability of the multiple resonance modes from visible to near-infrared is investigated and the unique properties are attractive to applications including angularly selective filtering to biosensing.

Kinematics, hydrodynamics and energetic advantages of burst-and-coast swimming of koi carps (Cyprinus carpio koi).

PubMed

Wu, Guanhao; Yang, Yan; Zeng, Lijiang

2007-06-01

Koi carps frequently swim in burst-and-coast style, which consists of a burst phase and a coast phase. We quantify the swimming kinematics and the flow patterns generated by the carps in burst-and-coast swimming. In the burst phase, the carps burst in two modes: in the first, the tail beats for at least one cycle (multiple tail-beat mode); in the second, the tail beats for only a half-cycle (half tail-beat mode). The carp generates a vortex ring in each half-cycle beat. The vortex rings generated during bursting in multiple tail-beat mode form a linked chain, but only one vortex ring is generated in half tail-beat mode. The wake morphologies, such as momentum angle and jet angle, also show much difference between the two modes. In the burst phase, the kinematic data and the impulse obtained from the wake are linked to obtain the drag coefficient (C(d,burst) approximately 0.242). In the coast phase, drag coefficient (C(d,coast) approximately 0.060) is estimated from swimming speed deceleration. Our estimation suggests that nearly 45% of energy is saved when burst-and-coast swimming is used by the koi carps compared with steady swimming at the same mean speed.

Probing plasmonic breathing modes optically

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krug, Markus K., E-mail: markus.krug@uni-graz.at; Reisecker, Michael; Hohenau, Andreas

2014-10-27

The confinement of surface plasmon modes in flat nanoparticles gives rise to plasmonic breathing modes. With a vanishing net dipole moment, breathing modes do not radiate, i.e., they are optically dark. Having thus escaped optical detection, breathing modes were only recently revealed in silver nanodisks with electron energy loss spectroscopy in an electron microscope. We show that for disk diameters >200 nm, retardation induced by oblique optical illumination relaxes the optically dark character. This makes breathing modes and thus the full plasmonic mode spectrum accessible to optical spectroscopy. The experimental spectroscopy data are in excellent agreement with numerical simulations.

Optical sensing of analytes in aqueous solutions with a multiple surface-plasmon-polariton-wave platform

PubMed Central

Swiontek, Stephen E.; Pulsifer, Drew P.; Lakhtakia, Akhlesh

2013-01-01

The commonly used optical sensor based on surface plasmon-polariton wave phenomenon can sense just one chemical, because only one SPP wave can be guided by the interface of a metal and a dielectric material contained in the sensor. Multiple analytes could be detected and/or the sensing reliability for a single analyte could be enhanced, if multiple SPP-wave modes could be excited on a single metal/dielectric interface. For that to happen, the partnering dielectric material must be periodically non-homogeneous. Using a chiral sculptured thin film (CSTF) as that material in a SPP-wave platform, we show that the angular locations of multiple SPP-wave modes shift when the void regions of the CSTF are infiltrated with a fluid. The sensitivities realized in the proof-of-concept experiments are comparable to state-of-research values. PMID:23474988

Realization of multiple orbital angular momentum modes simultaneously through four-dimensional antenna arrays.

PubMed

Sun, Chao; Yang, Shiwen; Chen, Yikai; Guo, Jixin; Qu, Shiwei

2018-01-09

Electromagnetic waves carrying orbital angular momentum (OAM) in radio frequency range have drawn great attention owing to its potential applications in increasing communication capacity. In this paper, both single-pole single-throw (SPST) switches and single-pole double-throw (SPDT) switches are designed and implemented. Optimal time sequence allows four-dimensional (4-D) circular antenna array to generate multiple OAM-carrying waves as well as enhance the field intensity of each OAM-carrying wave. A novel experimental platform is developed to measure the phase distribution when the transmitting antenna and the receiving antenna operate at different frequencies. The good agreement between the measurement and simulation results demonstrate that 4-D circular antenna array is able to generate multiple OAM modes simultaneously. Furthermore, the superiority of the 4-D circular antenna array in receiving and demodulating multiple OAM-carrying signals is validated through the filter and bit error rate (BER) simulations.

Differential responses in dorsal visual cortex to motion and disparity depth cues

PubMed Central

Arnoldussen, David M.; Goossens, Jeroen; van den Berg, Albert V.

2013-01-01

We investigated how interactions between monocular motion parallax and binocular cues to depth vary in human motion areas for wide-field visual motion stimuli (110 × 100°). We used fMRI with an extensive 2 × 3 × 2 factorial blocked design in which we combined two types of self-motion (translational motion and translational + rotational motion), with three categories of motion inflicted by the degree of noise (self-motion, distorted self-motion, and multiple object-motion), and two different view modes of the flow patterns (stereo and synoptic viewing). Interactions between disparity and motion category revealed distinct contributions to self- and object-motion processing in 3D. For cortical areas V6 and CSv, but not the anterior part of MT+ with bilateral visual responsiveness (MT+/b), we found a disparity-dependent effect of rotational flow and noise: When self-motion perception was degraded by adding rotational flow and moderate levels of noise, the BOLD responses were reduced compared with translational self-motion alone, but this reduction was cancelled by adding stereo information which also rescued the subject's self-motion percept. At high noise levels, when the self-motion percept gave way to a swarm of moving objects, the BOLD signal strongly increased compared to self-motion in areas MT+/b and V6, but only for stereo in the latter. BOLD response did not increase for either view mode in CSv. These different response patterns indicate different contributions of areas V6, MT+/b, and CSv to the processing of self-motion perception and the processing of multiple independent motions. PMID:24339808

Instability analysis and free volume simulations of shear band directions and arrangements in notched metallic glasses

DOE PAGES

Li, Weidong; Gao, Yanfei; Bei, Hongbin

2016-10-10

As a commonly used method to enhance the ductility in bulk metallic glasses (BMGs), the introduction of geometric constraints blocks and confines the propagation of the shear bands, reduces the degree of plastic strain on each shear band so that the catastrophic failure is prevented or delayed, and promotes the formation of multiple shear bands. The clustering of multiple shear bands near notches is often interpreted as the reason for improved ductility. Experimental works on the shear band arrangements in notched metallic glasses have been extensively carried out, but a systematic theoretical study is lacking. Using instability theory that predictsmore » the onset of strain localization and the free-volume- based nite element simulations that predict the evolution of shear bands, this work reveals various categories of shear band arrangements in double edge notched BMGs with respect to the mode mixity of the applied stress fields. In conclusion, a mechanistic explanation is thus provided to a number of related experiments and especially the correlation between various types of shear bands and the stress state.« less

Universality in the tail of musical note rank distribution

NASA Astrophysics Data System (ADS)

Beltrán del Río, M.; Cocho, G.; Naumis, G. G.

2008-09-01

Although power laws have been used to fit rank distributions in many different contexts, they usually fail at the tails. Languages as sequences of symbols have been a popular subject for ranking distributions, and for this purpose, music can be treated as such. Here we show that more than 1800 musical compositions are very well fitted by the first kind two parameter beta distribution, which arises in the ranking of multiplicative stochastic processes. The parameters a and b are obtained for classical, jazz and rock music, revealing interesting features. Specially, we have obtained a clear trend in the values of the parameters for major and minor tonal modes. Finally, we discuss the distribution of notes for each octave and its connection with the ranking of the notes.

Ultrastable, Zerodur-based optical benches for quantum gas experiments.

PubMed

Duncker, Hannes; Hellmig, Ortwin; Wenzlawski, André; Grote, Alexander; Rafipoor, Amir Jones; Rafipoor, Mona; Sengstock, Klaus; Windpassinger, Patrick

2014-07-10

Operating ultracold quantum gas experiments outside of a laboratory environment has so far been a challenging goal, largely due to the lack of sufficiently stable optical systems. In order to increase the thermal stability of free-space laser systems, the application of nonstandard materials such as glass ceramics is required. Here, we report on Zerodur-based optical systems which include single-mode fiber couplers consisting of multiple components jointed by light-curing adhesives. The thermal stability is thoroughly investigated, revealing excellent fiber-coupling efficiencies between 0.85 and 0.92 in the temperature range from 17°C to 36°C. In conjunction with successfully performed vibration tests, these findings qualify our highly compact systems for atom interferometry experiments aboard a sounding rocket as well as various other quantum information and sensing applications.

A broadband ASE light source-based full-duplex FTTX/ROF transport system.

PubMed

Chang, Ching-Hung; Lu, Hai-Han; Su, Heng-Sheng; Shih, Chien-Liang; Chen, Kai-Jen

2009-11-23

A full-duplex fiber-to-the-X (FTTX)/radio-over-fiber (ROF) transport system based on a broadband amplified spontaneous emission (ASE) light source is proposed and demonstrated for rural wide-spread villages. Combining the concepts of long-transmission transmission and ring topology, a long-haul single-mode fiber (SMF) trunk is sharing with multiple rural villages. Externally modulated baseband (BB) (1.25 Gbps) and radio-frequency (RF) (622 Mbps/10 GHz) signals are successfully transmitted simultaneously. Good bit error rate (BER) performance was achieved to demonstrate the practice of providing wire/wireless connections for long-haul wide-spread rural villages. Since our proposed system uses only a broadband ASE light source to achieve multi-wavelengths transmissions, it also reveals an outstanding one with simpler and more economic advantages.

Opto-electronic oscillators having optical resonators

NASA Technical Reports Server (NTRS)

Yao, Xiaotian Steve (Inventor); Maleki, Lutfollah (Inventor); Ilchenko, Vladimir (Inventor)

2003-01-01

Systems and techniques of incorporating an optical resonator in an optical part of a feedback loop in opto-electronic oscillators. This optical resonator provides a sufficiently long energy storage time and hence to produce an oscillation of a narrow linewidth and low phase noise. Certain mode matching conditions are required. For example, the mode spacing of the optical resonator is equal to one mode spacing, or a multiplicity of the mode spacing, of an opto-electronic feedback loop that receives a modulated optical signal and to produce an electrical oscillating signal.

Active damping of modal vibrations by force apportioning

NASA Technical Reports Server (NTRS)

Hallauer, W. L., Jr.

1980-01-01

Force apportioning, a method of active structural damping based on that used in modal vibration testing of isolating modes by multiple shaker excitation, was analyzed and numerically simulated. A distribution of as few forces as possible on the structure is chosen so as to maximally affect selected vibration modes while minimally exciting all other modes. The accuracy of numerical simulations of active damping, active damping of higher-frequency modes, and studies of imperfection sensitivity are discussed. The computer programs developed are described and possible refinements of the research are examined.

How to deal with multiple binding poses in alchemical relative protein-ligand binding free energy calculations.

PubMed

Kaus, Joseph W; Harder, Edward; Lin, Teng; Abel, Robert; McCammon, J Andrew; Wang, Lingle

2015-06-09

Recent advances in improved force fields and sampling methods have made it possible for the accurate calculation of protein–ligand binding free energies. Alchemical free energy perturbation (FEP) using an explicit solvent model is one of the most rigorous methods to calculate relative binding free energies. However, for cases where there are high energy barriers separating the relevant conformations that are important for ligand binding, the calculated free energy may depend on the initial conformation used in the simulation due to the lack of complete sampling of all the important regions in phase space. This is particularly true for ligands with multiple possible binding modes separated by high energy barriers, making it difficult to sample all relevant binding modes even with modern enhanced sampling methods. In this paper, we apply a previously developed method that provides a corrected binding free energy for ligands with multiple binding modes by combining the free energy results from multiple alchemical FEP calculations starting from all enumerated poses, and the results are compared with Glide docking and MM-GBSA calculations. From these calculations, the dominant ligand binding mode can also be predicted. We apply this method to a series of ligands that bind to c-Jun N-terminal kinase-1 (JNK1) and obtain improved free energy results. The dominant ligand binding modes predicted by this method agree with the available crystallography, while both Glide docking and MM-GBSA calculations incorrectly predict the binding modes for some ligands. The method also helps separate the force field error from the ligand sampling error, such that deviations in the predicted binding free energy from the experimental values likely indicate possible inaccuracies in the force field. An error in the force field for a subset of the ligands studied was identified using this method, and improved free energy results were obtained by correcting the partial charges assigned to the ligands. This improved the root-mean-square error (RMSE) for the predicted binding free energy from 1.9 kcal/mol with the original partial charges to 1.3 kcal/mol with the corrected partial charges.

How To Deal with Multiple Binding Poses in Alchemical Relative Protein–Ligand Binding Free Energy Calculations

PubMed Central

2016-01-01

Recent advances in improved force fields and sampling methods have made it possible for the accurate calculation of protein–ligand binding free energies. Alchemical free energy perturbation (FEP) using an explicit solvent model is one of the most rigorous methods to calculate relative binding free energies. However, for cases where there are high energy barriers separating the relevant conformations that are important for ligand binding, the calculated free energy may depend on the initial conformation used in the simulation due to the lack of complete sampling of all the important regions in phase space. This is particularly true for ligands with multiple possible binding modes separated by high energy barriers, making it difficult to sample all relevant binding modes even with modern enhanced sampling methods. In this paper, we apply a previously developed method that provides a corrected binding free energy for ligands with multiple binding modes by combining the free energy results from multiple alchemical FEP calculations starting from all enumerated poses, and the results are compared with Glide docking and MM-GBSA calculations. From these calculations, the dominant ligand binding mode can also be predicted. We apply this method to a series of ligands that bind to c-Jun N-terminal kinase-1 (JNK1) and obtain improved free energy results. The dominant ligand binding modes predicted by this method agree with the available crystallography, while both Glide docking and MM-GBSA calculations incorrectly predict the binding modes for some ligands. The method also helps separate the force field error from the ligand sampling error, such that deviations in the predicted binding free energy from the experimental values likely indicate possible inaccuracies in the force field. An error in the force field for a subset of the ligands studied was identified using this method, and improved free energy results were obtained by correcting the partial charges assigned to the ligands. This improved the root-mean-square error (RMSE) for the predicted binding free energy from 1.9 kcal/mol with the original partial charges to 1.3 kcal/mol with the corrected partial charges. PMID:26085821

Modes of Interaction of Pleckstrin Homology Domains with Membranes: Toward a Computational Biochemistry of Membrane Recognition.

PubMed

Naughton, Fiona B; Kalli, Antreas C; Sansom, Mark S P

2018-02-02

Pleckstrin homology (PH) domains mediate protein-membrane interactions by binding to phosphatidylinositol phosphate (PIP) molecules. The structural and energetic basis of selective PH-PIP interactions is central to understanding many cellular processes, yet the molecular complexities of the PH-PIP interactions are largely unknown. Molecular dynamics simulations using a coarse-grained model enables estimation of free-energy landscapes for the interactions of 12 different PH domains with membranes containing PIP 2 or PIP 3 , allowing us to obtain a detailed molecular energetic understanding of the complexities of the interactions of the PH domains with PIP molecules in membranes. Distinct binding modes, corresponding to different distributions of cationic residues on the PH domain, were observed, involving PIP interactions at either the "canonical" (C) and/or "alternate" (A) sites. PH domains can be grouped by the relative strength of their C- and A-site interactions, revealing that a higher affinity correlates with increased C-site interactions. These simulations demonstrate that simultaneous binding of multiple PIP molecules by PH domains contributes to high-affinity membrane interactions, informing our understanding of membrane recognition by PH domains in vivo. Copyright © 2017. Published by Elsevier Ltd.

Anisotropic mechanical behaviors and their structural dependences of crossed-lamellar structure in a bivalve shell.

PubMed

Jiao, D; Liu, Z Q; Qu, R T; Zhang, Z F

2016-02-01

Crossed-lamellar structure is one of the most common organizations found in mollusk shells and may serve as a natural mimetic model for designing bio-inspired synthetic materials. Nonetheless, the mechanical behaviors and corresponding mechanisms have rarely been investigated for individual macro-layer of such structure. The integrated effects of orientation and hydration also remain unclear. In this study, the mechanical behaviors and their structural dependences of pure crossed-lamellar structure in Saxidomus purpuratus shell were systematically examined by three-point bending and compression tests. Mechanical properties and fracture mechanisms were revealed to depend strongly on the orientation, hydration state and loading condition. Three basic cracking modes of inter-platelet, trans-platelet, and along the interfaces between first-order lamellae were identified, and the interfacial separation was enhanced by hydration. Macroscopic compressive fracture was accomplished through axial splitting during which multiple toughening mechanisms were activated. The competition among different cracking modes was quantitatively evaluated by analyzing their driving stresses and resistances from fundamental mechanics. This study helps to clarify the mechanical behaviors of naturally occurring crossed-lamellar structure, and accordingly, aids in designing new bio-inspired synthetic materials by mimicking it. Copyright © 2015 Elsevier B.V. All rights reserved.

Analysis of the impact of crude oil price fluctuations on China's stock market in different periods-Based on time series network model

NASA Astrophysics Data System (ADS)

An, Yang; Sun, Mei; Gao, Cuixia; Han, Dun; Li, Xiuming

2018-02-01

This paper studies the influence of Brent oil price fluctuations on the stock prices of China's two distinct blocks, namely, the petrochemical block and the electric equipment and new energy block, applying the Shannon entropy of information theory. The co-movement trend of crude oil price and stock prices is divided into different fluctuation patterns with the coarse-graining method. Then, the bivariate time series network model is established for the two blocks stock in five different periods. By joint analysis of the network-oriented metrics, the key modes and underlying evolutionary mechanisms were identified. The results show that the both networks have different fluctuation characteristics in different periods. Their co-movement patterns are clustered in some key modes and conversion intermediaries. The study not only reveals the lag effect of crude oil price fluctuations on the stock in Chinese industry blocks but also verifies the necessity of research on special periods, and suggests that the government should use different energy policies to stabilize market volatility in different periods. A new way is provided to study the unidirectional influence between multiple variables or complex time series.

Core heat convection in NSTX-U via modification of electron orbits by high frequency Alfvén eigenmodes

NASA Astrophysics Data System (ADS)

Crocker, N. A.; Tritz, K.; White, R. B.; Fredrickson, E. D.; Gorelenkov, N. N.; NSTX-U Team

2015-11-01

New simulation results demonstrate that high frequency compressional (CAE) and global (GAE) Alfvén eigenmodes cause radial convection of electrons, with implications for particle and energy confinement, as well as electric field formation in NSTX-U. Simulations of electron orbits in the presence of multiple experimentally determined CAEs and GAEs, using the gyro-center code ORBIT, have revealed substantial convective transport, in addition to the expected diffusion via orbit stochastization. These results advance understanding of anomalous core energy transport expected in high performance, beam-heated NSTX-U plasmas. The simulations make use of experimentally determined density perturbation (δn) amplitudes and mode structures obtained by inverting measurements from 16 a channel reflectometer array using a synthetic diagnostic. Combined with experimentally determined mode polarizations (i.e. CAE or GAE), the δn are used to estimate the ExB displacements for use in ORBIT. Preliminary comparison of the simulation results with transport modeling by TRANSP indicate that the convection is currently underestimated. Supported by US DOE Contracts DE-SC0011810, DE-FG02-99ER54527 & DE-AC02-09CH11466.

2013 R&D 100 Award: Movie-mode electron microscope captures nanoscale

ScienceCinema

Lagrange, Thomas; Reed, Bryan

2018-01-26

A new instrument developed by LLNL scientists and engineers, the Movie Mode Dynamic Transmission Electron Microscope (MM-DTEM), captures billionth-of-a-meter-scale images with frame rates more than 100,000 times faster than those of conventional techniques. The work was done in collaboration with a Pleasanton-based company, Integrated Dynamic Electron Solutions (IDES) Inc. Using this revolutionary imaging technique, a range of fundamental and technologically important material and biological processes can be captured in action, in complete billionth-of-a-meter detail, for the first time. The primary application of MM-DTEM is the direct observation of fast processes, including microstructural changes, phase transformations and chemical reactions, that shape real-world performance of nanostructured materials and potentially biological entities. The instrument could prove especially valuable in the direct observation of macromolecular interactions, such as protein-protein binding and host-pathogen interactions. While an earlier version of the technology, Single Shot-DTEM, could capture a single snapshot of a rapid process, MM-DTEM captures a multiframe movie that reveals complex sequences of events in detail. It is the only existing technology that can capture multiple electron microscopy images in the span of a single microsecond.

Situating the default-mode network along a principal gradient of macroscale cortical organization

PubMed Central

Margulies, Daniel S.; Goulas, Alexandros; Falkiewicz, Marcel; Huntenburg, Julia M.; Langs, Georg; Bezgin, Gleb; Eickhoff, Simon B.; Castellanos, F. Xavier; Petrides, Michael; Jefferies, Elizabeth; Smallwood, Jonathan

2016-01-01

Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface—and are precisely equidistant—from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional metaanalysis. Together, these observations provide a characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input. PMID:27791099

Microscopy reveals disease control through novel effects on fungal development: a case study with an early-generation benzophenone fungicide.

PubMed

Schmitt, Mark R; Carzaniga, Raffaella; Cotter, H Van T; O'Connell, Richard; Hollomon, Derek

2006-05-01

The benzophenones are a new class of agricultural fungicides that demonstrate protectant, curative and eradicative/antisporulant activity against powdery mildews. The chemistry is represented in the marketplace by the fungicide metrafenone, recently introduced by BASF and discussed in the following paper. The benzophenones show no evidence of acting by previously identified biochemical mechanisms, nor do they show cross-resistance with existing fungicides. The value of microscopy in elucidating fungicide mode of action is demonstrated through identification of the effects of an early benzophenone, eBZO, on mildew development. eBZO caused profound alterations in the morphology of powdery mildews of both monocotyledons and dicotyledons, affecting multiple stages of fungal development, including spore germination, appressorial formation, penetration, surface hyphal morphology and sporogenesis. Identification of analogous effects of eBZO on sporulation in the model organism Aspergillus nidulans (Eidam) Winter provides a unique opportunity to elucidate important morphogenetic regulatory sites in the economically important obligate pathogens, the powdery mildews. Benzophenones provide a further example of the benefits of whole-organism testing in the search for novel fungicide modes of action. Copyright 2006 Society of Chemical Industry.

Collective behavior of stock price movements in an emerging market

NASA Astrophysics Data System (ADS)

Pan, Raj Kumar; Sinha, Sitabhra

2007-10-01

To investigate the universality of the structure of interactions in different markets, we analyze the cross-correlation matrix C of stock price fluctuations in the National Stock Exchange (NSE) of India. We find that this emerging market exhibits strong correlations in the movement of stock prices compared to developed markets, such as the New York Stock Exchange (NYSE). This is shown to be due to the dominant influence of a common market mode on the stock prices. By comparison, interactions between related stocks, e.g., those belonging to the same business sector, are much weaker. This lack of distinct sector identity in emerging markets is explicitly shown by reconstructing the network of mutually interacting stocks. Spectral analysis of C for NSE reveals that, the few largest eigenvalues deviate from the bulk of the spectrum predicted by random matrix theory, but they are far fewer in number compared to, e.g., NYSE. We show this to be due to the relative weakness of intrasector interactions between stocks, compared to the market mode, by modeling stock price dynamics with a two-factor model. Our results suggest that the emergence of an internal structure comprising multiple groups of strongly coupled components is a signature of market development.

2013 R&D 100 Award: Movie-mode electron microscope captures nanoscale

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lagrange, Thomas; Reed, Bryan

2014-04-03

A new instrument developed by LLNL scientists and engineers, the Movie Mode Dynamic Transmission Electron Microscope (MM-DTEM), captures billionth-of-a-meter-scale images with frame rates more than 100,000 times faster than those of conventional techniques. The work was done in collaboration with a Pleasanton-based company, Integrated Dynamic Electron Solutions (IDES) Inc. Using this revolutionary imaging technique, a range of fundamental and technologically important material and biological processes can be captured in action, in complete billionth-of-a-meter detail, for the first time. The primary application of MM-DTEM is the direct observation of fast processes, including microstructural changes, phase transformations and chemical reactions, that shapemore » real-world performance of nanostructured materials and potentially biological entities. The instrument could prove especially valuable in the direct observation of macromolecular interactions, such as protein-protein binding and host-pathogen interactions. While an earlier version of the technology, Single Shot-DTEM, could capture a single snapshot of a rapid process, MM-DTEM captures a multiframe movie that reveals complex sequences of events in detail. It is the only existing technology that can capture multiple electron microscopy images in the span of a single microsecond.« less

Exact docking flight controller for autonomous aerial refueling with back-stepping based high order sliding mode

NASA Astrophysics Data System (ADS)

Su, Zikang; Wang, Honglun; Li, Na; Yu, Yue; Wu, Jianfa

2018-02-01

Autonomous aerial refueling (AAR) exact docking control has always been an intractable problem due to the strong nonlinearity, the tight coupling of the 6 DOF aircraft model and the complex disturbances of the multiple environment flows. In this paper, the strongly coupled nonlinear 6 DOF model of the receiver aircraft which considers the multiple flow disturbances is established in the affine nonlinear form to facilitate the nonlinear controller design. The items reflecting the influence of the unknown flow disturbances in the receiver dynamics are taken as the components of the "lumped disturbances" together with the items which have no linear correlation with the virtual control variables. These unmeasurable lumped disturbances are estimated and compensated by a specially designed high order sliding mode observer (HOSMO) with excellent estimation property. With the compensation of the estimated lumped disturbances, a back-stepping high order sliding mode based exact docking flight controller is proposed for AAR in the presence of multiple flow disturbances. Extensive simulation results demonstrate the feasibility and superiority of the proposed docking controller.

Subpercent-Scale Control of 3D Low Modes of Targets Imploded in Direct-Drive Configuration on OMEGA

NASA Astrophysics Data System (ADS)

Michel, D. T.; Igumenshchev, I. V.; Davis, A. K.; Edgell, D. H.; Froula, D. H.; Jacobs-Perkins, D. W.; Goncharov, V. N.; Regan, S. P.; Shvydky, A.; Campbell, E. M.

2018-03-01

Multiple self-emission x-ray images are used to measure tomographically target modes 1, 2, and 3 up to the end of the target acceleration in direct-drive implosions on OMEGA. Results show that the modes consist of two components: the first varies linearly with the laser beam-energy balance and the second is static and results from physical effects including beam mistiming, mispointing, and uncertainty in beam energies. This is used to reduce the target low modes of low-adiabat implosions from 2.2% to 0.8% by adjusting the beam-energy balance to compensate these static modes.

Quasi-regenerative mode locking in a compact all-polarisation-maintaining-fibre laser

NASA Astrophysics Data System (ADS)

Nyushkov, B. N.; Ivanenko, A. V.; Kobtsev, S. M.; Pivtsov, V. S.; Farnosov, S. A.; Pokasov, P. V.; Korel, I. I.

2017-12-01

A novel technique of mode locking in erbium-doped all-polarisation-maintaining-fibre laser has been developed and preliminary investigated. The proposed quasi-regenerative technique combines the advantages of conventional active mode locking (when an intracavity modulator is driven by an independent RF oscillator) and regenerative mode locking (when a modulator is driven by an intermode beat signal from the laser itself). This scheme is based on intracavity intensity modulation driven by an RF oscillator being phase-locked to the actual intermode frequency of the laser. It features also possibilities of operation at multiple frequencies and harmonic mode-locking operation.

Principal Component Relaxation Mode Analysis of an All-Atom Molecular Dynamics Simulation of Human Lysozyme

NASA Astrophysics Data System (ADS)

Nagai, Toshiki; Mitsutake, Ayori; Takano, Hiroshi

2013-02-01

A new relaxation mode analysis method, which is referred to as the principal component relaxation mode analysis method, has been proposed to handle a large number of degrees of freedom of protein systems. In this method, principal component analysis is carried out first and then relaxation mode analysis is applied to a small number of principal components with large fluctuations. To reduce the contribution of fast relaxation modes in these principal components efficiently, we have also proposed a relaxation mode analysis method using multiple evolution times. The principal component relaxation mode analysis method using two evolution times has been applied to an all-atom molecular dynamics simulation of human lysozyme in aqueous solution. Slow relaxation modes and corresponding relaxation times have been appropriately estimated, demonstrating that the method is applicable to protein systems.

Heterogeneity and dynamics of the ligand recognition mode in purine-sensing riboswitches.

PubMed

Jain, Niyati; Zhao, Liang; Liu, John D; Xia, Tianbing

2010-05-04

High-resolution crystal structures and biophysical analyses of purine-sensing riboswitches have revealed that a network of hydrogen bonding interactions appear to be largey responsible for discrimination of cognate ligands against structurally related compounds. Here we report that by using femtosecond time-resolved fluorescence spectroscopy to capture the ultrafast decay dynamics of the 2-aminopurine base as the ligand, we have detected the presence of multiple conformations of the ligand within the binding pockets of one guanine-sensing and two adenine-sensing riboswitches. All three riboswitches have similar conformational distributions of the ligand-bound state. The known crystal structures represent the global minimum that accounts for 50-60% of the population, where there is no significant stacking interaction between the ligand and bases of the binding pocket, but the hydrogen-bonding cage collectively provides an electronic environment that promotes an ultrafast ( approximately 1 ps) charge transfer pathway. The ligand also samples multiple conformations in which it significantly stacks with either the adenine or the uracil bases of the A21-U75 and A52-U22 base pairs that form the ceiling and floor of the binding pocket, respectively, but favors the larger adenine bases. These alternative conformations with well-defined base stacking interactions are approximately 1-1.5 kcal/mol higher in DeltaG degrees than the global minimum and have distinct charge transfer dynamics within the picosecond to nanosecond time regime. Inside the pocket, the purine ligand undergoes dynamic motion on the low nanosecond time scale, sampling the multiple conformations based on time-resolved anisotropy decay dynamics. These results allowed a description of the energy landscape of the bound ligand with intricate details and demonstrated the elastic nature of the ligand recognition mode by the purine-sensing riboswitches, where there is a dynamic balance between hydrogen bonding and base stacking interactions, yielding the high affinity and specificity by the aptamer domain.

Bicoherence Analysis of Electrostatic Interchange Mode Coupling in a Turbulent Laboratory Magnetosphere

NASA Astrophysics Data System (ADS)

Abler, M. C.; Mauel, M. E.; Saperstein, A.

2017-12-01

Plasmas confined by a strong dipole field exhibit interchange and entropy mode turbulence, which previous experiments have shown respond locally to active feedback [1]. On the Collisionless Terrella Experiment (CTX), this turbulence is characterized by low frequency, low order, quasi-coherent modes with complex spectral dynamics. We apply bicoherence analysis [2] to study nonlinear phase coupling in a variety of scenarios. First, we study the self-interaction of the naturally occurring interchange turbulence; this analysis is then expanded to include the effects of single or multiple driven modes in the frequency range of the background turbulent oscillations. Initial measurements of coupling coefficients are presented in both cases. Driven low frequency interchange modes are observed to generate multiple harmonics which persist throughout the plasma, becoming weaker as they propagate away from the actuator in the direction of the electron magnetic drift. Future work is also discussed, including application of wavelet bicoherence analysis and applications to planetary magnetospheres. [1] Roberts, Mauel, and Worstell, Phys Plasmas (2015). [2] Grierson, Worstell, and Mauel, Phys Plasmas (2009). Supported by NSF-DOE Partnership for Plasma Science Grants DOE-DE-FG02-00ER54585 and NSF-PHY-1201896.

Detection and characterization of nonspecific, sparsely-populated binding modes in the early stages of complexation

PubMed Central

Cardone, A.; Bornstein, A.; Pant, H. C.; Brady, M.; Sriram, R.; Hassan, S. A.

2015-01-01

A method is proposed to study protein-ligand binding in a system governed by specific and non-specific interactions. Strong associations lead to narrow distributions in the proteins configuration space; weak and ultra-weak associations lead instead to broader distributions, a manifestation of non-specific, sparsely-populated binding modes with multiple interfaces. The method is based on the notion that a discrete set of preferential first-encounter modes are metastable states from which stable (pre-relaxation) complexes at equilibrium evolve. The method can be used to explore alternative pathways of complexation with statistical significance and can be integrated into a general algorithm to study protein interaction networks. The method is applied to a peptide-protein complex. The peptide adopts several low-population conformers and binds in a variety of modes with a broad range of affinities. The system is thus well suited to analyze general features of binding, including conformational selection, multiplicity of binding modes, and nonspecific interactions, and to illustrate how the method can be applied to study these problems systematically. The equilibrium distributions can be used to generate biasing functions for simulations of multiprotein systems from which bulk thermodynamic quantities can be calculated. PMID:25782918

A Patch to MCNP5 for Multiplication Inference: Description and User Guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Solomon, Jr., Clell J.

2014-05-05

A patch to MCNP5 has been written to allow generation of multiple neutrons from a spontaneous-fission event and generate list-mode output. This report documents the implementation and usage of this patch.

Spin wave mode coexistence on the nanoscale: A consequence of the Oersted field induced asymmetric energy landscape

NASA Astrophysics Data System (ADS)

Dumas, Randy

2014-03-01

The emerging field of magnonics relies on the systematic generation, manipulation, and detection of spin waves (SWs). Nanocontact spin torque oscillators (NC-STOs) provide an ideal platform to study spin transfer torque induced SW emission. In analogy to two species competing for the same food supply it has been argued that only one SW mode can survive in the steady state. However, as evidenced in many experiments clear signatures of mode-hopping are often observed. Here, we present a third possibility, namely that under the correct experimental conditions, mode coexistencecan be realized in NC-STOs. Micromagnetic simulations reveal that the SW modes are spatially separated under the NC. Mode coexistence is facilitated by the local field asymmetries induced by the spatially inhomogeneous Oersted field in the vicinity of the NC and further promoted by SW localization. Finally, both simulation and experiment reveal a weak low frequency signal exactly at the difference of the mode frequencies, consistent with inter-modulation of two coexistent modes. The Swedish Research Council, The Swedish Foundation for Strategic Research, and the Knut and Alice Wallenberg Foundation are acknowledged. ANL is a US DOE Science Laboratory operated under contract no. DE-AC02-06CH11357 by UChicago Argonne, LLC.

Polarization-insensitive PAM-4-carrying free-space orbital angular momentum (OAM) communications.

PubMed

Liu, Jun; Wang, Jian

2016-02-22

We present a simple configuration incorporating single polarization-sensitive phase-only liquid crystal spatial light modulator (SLM) to facilitate polarization-insensitive free-space optical communications employing orbital angular momentum (OAM) modes. We experimentally demonstrate several polarization-insensitive optical communication subsystems by propagating a single OAM mode, multicasting 4 and 10 OAM modes, and multiplexing 8 OAM modes, respectively. Free-space polarization-insensitive optical communication links using OAM modes that carry four-level pulse-amplitude modulation (PAM-4) signal are demonstrated in the experiment. The observed optical signal-to-noise ratio (OSNR) penalties are less than 1 dB in both polarization-insensitive N-fold OAM modes multicasting and multiple OAM modes multiplexing at a bit-error rate (BER) of 2e-3 (enhanced forward-error correction (EFEC) threshold).

Spatiotemporal mode-locking in multimode fiber lasers

NASA Astrophysics Data System (ADS)

Wright, Logan G.; Christodoulides, Demetrios N.; Wise, Frank W.

2017-10-01

A laser is based on the electromagnetic modes of its resonator, which provides the feedback required for oscillation. Enormous progress has been made toward controlling the interactions of longitudinal modes in lasers with a single transverse mode. For example, the field of ultrafast science has been built on lasers that lock many longitudinal modes together to form ultrashort light pulses. However, coherent superposition of longitudinal and transverse modes in a laser has received little attention. We show that modal and chromatic dispersions in fiber lasers can be counteracted by strong spatial and spectral filtering. This allows locking of multiple transverse and longitudinal modes to create ultrashort pulses with a variety of spatiotemporal profiles. Multimode fiber lasers thus open new directions in studies of nonlinear wave propagation and capabilities for applications.

Common Dimensional Reward Deficits Across Mood and Psychotic Disorders: A Connectome-Wide Association Study.

PubMed

Sharma, Anup; Wolf, Daniel H; Ciric, Rastko; Kable, Joseph W; Moore, Tyler M; Vandekar, Simon N; Katchmar, Natalie; Daldal, Aylin; Ruparel, Kosha; Davatzikos, Christos; Elliott, Mark A; Calkins, Monica E; Shinohara, Russell T; Bassett, Danielle S; Satterthwaite, Theodore D

2017-07-01

Anhedonia is central to multiple psychiatric disorders and causes substantial disability. A dimensional conceptualization posits that anhedonia severity is related to a transdiagnostic continuum of reward deficits in specific neural networks. Previous functional connectivity studies related to anhedonia have focused on case-control comparisons in specific disorders, using region-specific seed-based analyses. Here, the authors explore the entire functional connectome in relation to reward responsivity across a population of adults with heterogeneous psychopathology. In a sample of 225 adults from five diagnostic groups (major depressive disorder, N=32; bipolar disorder, N=50; schizophrenia, N=51; psychosis risk, N=39; and healthy control subjects, N=53), the authors conducted a connectome-wide analysis examining the relationship between a dimensional measure of reward responsivity (the reward sensitivity subscale of the Behavioral Activation Scale) and resting-state functional connectivity using multivariate distance-based matrix regression. The authors identified foci of dysconnectivity associated with reward responsivity in the nucleus accumbens, the default mode network, and the cingulo-opercular network. Follow-up analyses revealed dysconnectivity among specific large-scale functional networks and their connectivity with the nucleus accumbens. Reward deficits were associated with decreased connectivity between the nucleus accumbens and the default mode network and increased connectivity between the nucleus accumbens and the cingulo-opercular network. In addition, impaired reward responsivity was associated with default mode network hyperconnectivity and diminished connectivity between the default mode network and the cingulo-opercular network. These results emphasize the centrality of the nucleus accumbens in the pathophysiology of reward deficits and suggest that dissociable patterns of connectivity among large-scale networks are critical to the neurobiology of reward dysfunction across clinical diagnostic categories.

Revealing spatio-spectral electroencephalographic dynamics of musical mode and tempo perception by independent component analysis.

PubMed

Lin, Yuan-Pin; Duann, Jeng-Ren; Feng, Wenfeng; Chen, Jyh-Horng; Jung, Tzyy-Ping

2014-02-28

Music conveys emotion by manipulating musical structures, particularly musical mode- and tempo-impact. The neural correlates of musical mode and tempo perception revealed by electroencephalography (EEG) have not been adequately addressed in the literature. This study used independent component analysis (ICA) to systematically assess spatio-spectral EEG dynamics associated with the changes of musical mode and tempo. Empirical results showed that music with major mode augmented delta-band activity over the right sensorimotor cortex, suppressed theta activity over the superior parietal cortex, and moderately suppressed beta activity over the medial frontal cortex, compared to minor-mode music, whereas fast-tempo music engaged significant alpha suppression over the right sensorimotor cortex. The resultant EEG brain sources were comparable with previous studies obtained by other neuroimaging modalities, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). In conjunction with advanced dry and mobile EEG technology, the EEG results might facilitate the translation from laboratory-oriented research to real-life applications for music therapy, training and entertainment in naturalistic environments.

Vibrational Mode-Specific Autodetachment and Coupling of CH2CN-

NASA Astrophysics Data System (ADS)

Lyle, Justin; Mabbs, Richard

2017-06-01

The Cyanomethyl Anion, CH_{2}CN-, and neutral radical have been studied extensively, with several findings of autodetachment about the totally symmetric transition, as well as high resolution experiments revealing symmetrically forbidden and weak vibrational features. We report photoelectron spectra using the Velocity-Mapped Imaging Technique in 1-2 \\wn increments over a range of 13460 to 15384 \\wn that has not been previously examined. These spectra include excitation of the ground state cyanomethyl anion into the direct detachment thresholds of previously reported vibrational modes for the neutral radical. Significant variations from Franck-Condon behavior were observed in the branching ratios for resolved vibrational features for excitation in the vicinity of the thresholds involving the νb{3} and νb{5} modes. These are consistent with autodetachment from rovibrational levels of a dipole bound state acting as a resonance in the detachment continuum. The autodetachment channels involve single changes in vibrational quantum number, consistent with the vibrational propensity rule but in some cases reveal relaxation to a different vibrational mode indicating coupling between the modes and/or a breakdown of the normal mode approximation.

Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children.

PubMed

Wen, Hongwei; Liu, Yue; Rekik, Islem; Wang, Shengpei; Zhang, Jishui; Zhang, Yue; Peng, Yun; He, Huiguang

2017-08-01

Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder. Although previous TS studies revealed structural abnormalities in distinct corticobasal ganglia circuits, the topological alterations of the whole-brain white matter (WM) structural networks remain poorly understood. Here, we used diffusion MRI probabilistic tractography and graph theoretical analysis to investigate the topological organization of WM networks in 44 drug-naive TS children and 41 age- and gender-matched healthy children. The WM networks were constructed by estimating inter-regional connectivity probability and the topological properties were characterized using graph theory. We found that both TS and control groups showed an efficient small-world organization in WM networks. However, compared to controls, TS children exhibited decreased global and local efficiency, increased shortest path length and small worldness, indicating a disrupted balance between local specialization and global integration in structural networks. Although both TS and control groups showed highly similar hub distributions, TS children exhibited significant decreased nodal efficiency, mainly distributed in the default mode, language, visual, and sensorimotor systems. Furthermore, two separate networks showing significantly decreased connectivity in TS group were identified using network-based statistical (NBS) analysis, primarily composed of the parieto-occipital cortex, precuneus, and paracentral lobule. Importantly, we combined support vector machine and multiple kernel learning frameworks to fuse multiple levels of network topological features for classification of individuals, achieving high accuracy of 86.47%. Together, our study revealed the disrupted topological organization of structural networks related to pathophysiology of TS, and the discriminative topological features for classification are potential quantitative neuroimaging biomarkers for clinical TS diagnosis. Hum Brain Mapp 38:3988-4008, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Parametrically excited multidegree-of-freedom systems with repeated frequencies

NASA Astrophysics Data System (ADS)

Nayfeh, A. H.

1983-05-01

An analysis is presented of the linear response of multidegree-of-freedom systems with a repeated frequency of order three to a harmonic parametric excitation. The method of multiple scales is used to determine the modulation of the amplitudes and phases for two cases: fundamental resonance of the modes with the repeated frequency and combination resonance involving these modes and another mode. Conditions are then derived for determining the stability of the motion.

Interface circuit for a multiple-beam tuning-fork gyroscope with high quality factors

NASA Astrophysics Data System (ADS)

Wang, Ren

This research work presents the design, theoretical analysis, fabrication, interface electronics, and experimental results of a Silicon-On-Insulator (SOI) based Multiple-Beam Tuning-Fork Gyroscope (MB-TFG). Based on a numerical model of Thermo-Elastic Damping (TED), a Multiple-Beam Tuning-Fork Structure (MB-TFS) is designed with high Quality factors (Qs) in its two operation modes. A comprehensive theoretical analysis of the MB-TFG design is conducted to relate the design parameters to its operation parameters and further performance parameters. In conjunction with a mask that defines the device through trenches to alleviate severe fabrication effect on anchor loss, a simple one-mask fabrication process is employed to implement this MB-TFG design on SOI wafers. The fabricated MB-TFGs are tested with PCB-level interface electronics and a thorough comparison between the experimental results and a theoretical analysis is conducted to verify the MB-TFG design and accurately interpret the measured performance. The highest measured Qs of the fabricated MB-TFGs in vacuum are 255,000 in the drive-mode and 103,000 in the sense-mode, at a frequency of 15.7kHz. Under a frequency difference of 4Hz between the two modes (operation frequency is 16.8kHz) and a drive-mode vibration amplitude of 3.0um, the measured rate sensitivity is 80mVpp/°/s with an equivalent impedance of 6MQ. The calculated overall rate resolution of this device is 0.37/hrhiElz, while the measured Angle Random Walk (ARW) and bias instability are 6.67°/'vhr and 95°/hr, respectively.

Deconvolution of azimuthal mode detection measurements

NASA Astrophysics Data System (ADS)

Sijtsma, Pieter; Brouwer, Harry

2018-05-01

Unequally spaced transducer rings make it possible to extend the range of detectable azimuthal modes. The disadvantage is that the response of the mode detection algorithm to a single mode is distributed over all detectable modes, similarly to the Point Spread Function of Conventional Beamforming with microphone arrays. With multiple modes the response patterns interfere, leading to a relatively high "noise floor" of spurious modes in the detected mode spectrum, in other words, to a low dynamic range. In this paper a deconvolution strategy is proposed for increasing this dynamic range. It starts with separating the measured sound into shaft tones and broadband noise. For broadband noise modes, a standard Non-Negative Least Squares solver appeared to be a perfect deconvolution tool. For shaft tones a Matching Pursuit approach is proposed, taking advantage of the sparsity of dominant modes. The deconvolution methods were applied to mode detection measurements in a fan rig. An increase in dynamic range of typically 10-15 dB was found.

Moving target detection in flash mode against stroboscopic mode by active range-gated laser imaging

NASA Astrophysics Data System (ADS)

Zhang, Xuanyu; Wang, Xinwei; Sun, Liang; Fan, Songtao; Lei, Pingshun; Zhou, Yan; Liu, Yuliang

2018-01-01

Moving target detection is important for the application of target tracking and remote surveillance in active range-gated laser imaging. This technique has two operation modes based on the difference of the number of pulses per frame: stroboscopic mode with the accumulation of multiple laser pulses per frame and flash mode with a single shot of laser pulse per frame. In this paper, we have established a range-gated laser imaging system. In the system, two types of lasers with different frequency were chosen for the two modes. Electric fan and horizontal sliding track were selected as the moving targets to compare the moving blurring between two modes. Consequently, the system working in flash mode shows more excellent performance in motion blurring against stroboscopic mode. Furthermore, based on experiments and theoretical analysis, we presented the higher signal-to-noise ratio of image acquired by stroboscopic mode than flash mode in indoor and underwater environment.

Mathematical and Statistical Software Index.

DTIC Science & Technology

1986-08-01

geometric) mean HMEAN - harmonic mean MEDIAN - median MODE - mode QUANT - quantiles OGIVE - distribution curve IQRNG - interpercentile range RANGE ... range mutliphase pivoting algorithm cross-classification multiple discriminant analysis cross-tabul ation mul tipl e-objecti ve model curve fitting...Statistics). .. .. .... ...... ..... ...... ..... .. 21 *RANGEX (Correct Correlations for Curtailment of Range ). .. .. .... ...... ... 21 *RUMMAGE II (Analysis

40 CFR 1033.520 - Alternative ramped modal cycles.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Following the completion of the third test phase of the applicable ramped modal cycle, conduct the post... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM LOCOMOTIVES Test Procedures § 1033.520 Alternative ramped modal... locomotive notch settings. Ramped modal cycles combine multiple test modes of a discrete-mode steady-state...

Composing across Modes: A Comparative Analysis of Adolescents' Multimodal Composing Processes

ERIC Educational Resources Information Center

Smith, Blaine E.

2017-01-01

Although the shift from page to screen has dramatically redefined conceptions of writing, very little is known about how youth compose with multiple modes in digital environments. Integrating multimodality and multiliteracies theoretical frameworks, this comparative case study examined how urban twelfth-grade students collaboratively composed…

Communicating Like a Scientist with Multimodal Writing

ERIC Educational Resources Information Center

McDermott, Mark; Kuhn, Mason

2012-01-01

If students are to accurately model how scientists use written communication, they must be given opportunities to use creative means to describe science in the classroom. Scientists often integrate pictures, diagrams, charts, and other modes within text and students should also be encouraged to use multiple modes of communication. This article…

An electromechanical Ising Hamiltonian

PubMed Central

Mahboob, Imran; Okamoto, Hajime; Yamaguchi, Hiroshi

2016-01-01

Solving intractable mathematical problems in simulators composed of atoms, ions, photons, or electrons has recently emerged as a subject of intense interest. We extend this concept to phonons that are localized in spectrally pure resonances in an electromechanical system that enables their interactions to be exquisitely fashioned via electrical means. We harness this platform to emulate the Ising Hamiltonian whose spin 1/2 particles are replicated by the phase bistable vibrations from the parametric resonances of multiple modes. The coupling between the mechanical spins is created by generating two-mode squeezed states, which impart correlations between modes that can imitate a random, ferromagnetic state or an antiferromagnetic state on demand. These results suggest that an electromechanical simulator could be built for the Ising Hamiltonian in a nontrivial configuration, namely, for a large number of spins with multiple degrees of coupling. PMID:28861469

An electromechanical Ising Hamiltonian.

PubMed

Mahboob, Imran; Okamoto, Hajime; Yamaguchi, Hiroshi

2016-06-01

Solving intractable mathematical problems in simulators composed of atoms, ions, photons, or electrons has recently emerged as a subject of intense interest. We extend this concept to phonons that are localized in spectrally pure resonances in an electromechanical system that enables their interactions to be exquisitely fashioned via electrical means. We harness this platform to emulate the Ising Hamiltonian whose spin 1/2 particles are replicated by the phase bistable vibrations from the parametric resonances of multiple modes. The coupling between the mechanical spins is created by generating two-mode squeezed states, which impart correlations between modes that can imitate a random, ferromagnetic state or an antiferromagnetic state on demand. These results suggest that an electromechanical simulator could be built for the Ising Hamiltonian in a nontrivial configuration, namely, for a large number of spins with multiple degrees of coupling.

Prediction of multiple resonance characteristics by an extended resistor-inductor-capacitor circuit model for plasmonic metamaterials absorbers in infrared.

PubMed

Xu, Xiaolun; Li, Yongqian; Wang, Binbin; Zhou, Zili

2015-10-01

The resonance characteristics of plasmonic metamaterials absorbers (PMAs) are strongly dependent on geometric parameters. A resistor-inductor-capacitor (RLC) circuit model has been extended to predict the resonance wavelengths and the bandwidths of multiple magnetic polaritons modes in PMAs. For a typical metallic-dielectric-metallic structure absorber working in the infrared region, the developed model describes the correlation between the resonance characteristics and the dimensional sizes. In particular, the RLC model is suitable for not only the fundamental resonance mode, but also for the second- and third-order resonance modes. The prediction of the resonance characteristics agrees fairly well with those calculated by the finite-difference time-domain simulation and the experimental results. The developed RLC model enables the facilitation of designing multi-band PMAs for infrared radiation detectors and thermal emitters.

Effects of Multiple Simulation Presentation among Students of Different Anxiety Levels in the Learning of Probability

ERIC Educational Resources Information Center

Fong, Soon Fook; Por, Fei Ping; Tang, Ai Ling

2012-01-01

The purpose of this study was to investigate the effects of multiple simulation presentation in interactive multimedia are on the achievement of students with different levels of anxiety in the learning of Probability. The interactive multimedia courseware was developed in two different modes, which were Multiple Simulation Presentation (MSP) and…

Feasibility of large volume tumor ablation using multiple-mode strategy with fast scanning method: A numerical study

NASA Astrophysics Data System (ADS)

Wu, Hao; Shen, Guofeng; Qiao, Shan; Chen, Yazhu

2017-03-01

Sonication with fast scanning method can generate homogeneous lesions without complex planning. But when the target region is large, switching focus too fast will reduce the heat accumulation, the margin of which may not ablated. Furthermore, high blood perfusion rate will reduce this maximum volume that can be ablated. Therefore, fast scanning method may not be applied to large volume tumor. To expand the therapy scope, this study combines the fast scan method with multiple mode strategy. Through simulation and experiment, the feasibility of this new strategy is evaluated and analyzed.

Free vibration of multiwall carbon nanotubes

NASA Astrophysics Data System (ADS)

Wang, C. Y.; Ru, C. Q.; Mioduchowski, A.

2005-06-01

A multiple-elastic shell model is applied to systematically study free vibration of multiwall carbon nanotubes (MWNTs). Using Flugge [Stresses in Shells (Springer, Berlin, 1960)] equations of elastic shells, vibrational frequencies and associated modes are calculated for MWNTs of innermost radii 5 and 0.65 nm, respectively. The emphasis is placed on the effect of interlayer van der Waals (vdW) interaction on free vibration of MWNTs. Our results show that the interlayer vdW interaction has a crucial effect on radial (R) modes of large-radius MWNTs (e.g., of the innermost radius 5 nm), but is less pronounced for R modes of small-radius MWNTs (e.g., of the innermost radius 0.65 nm), and usually negligible for torsional (T) and longitudinal (L) modes of MWNTs. This is attributed to the fact that the interlayer vdW interaction, characterized by a radius-independent vdW interaction coefficient, depends on radial deflections only, and is dominant only for large-radius MWNTs of lower radial rigidity but less pronounced for small-radius MWNTs of much higher radial rigidity. As a result, the R modes of large-radius MWNTs are typically collective motions of almost all nested tubes, and the R modes of small-radius MWNTs, as well as the T and L modes of MWNTs, are basically vibrations of individual tubes. In particular, an approximate single-shell model is suggested to replace the multiple-shell model in calculating the lowest frequency of R mode of thin MWNTs (defined by the innermost radius-to-thickness ratio not less than 4) with relative errors less than 10%. In addition, the simplified Flugge single equation is adopted to substitute the exact Flugge equations in determining the R-mode frequencies of MWNTs with relative errors less than 10%.

Time-Frequency Analysis of the Dispersion of Lamb Modes

NASA Technical Reports Server (NTRS)

Prosser, W. H.; Seale, Michael D.; Smith, Barry T.

1999-01-01

Accurate knowledge of the velocity dispersion of Lamb modes is important for ultrasonic nondestructive evaluation methods used in detecting and locating flaws in thin plates and in determining their elastic stiffness coefficients. Lamb mode dispersion is also important in the acoustic emission technique for accurately triangulating the location of emissions in thin plates. In this research, the ability to characterize Lamb mode dispersion through a time-frequency analysis (the pseudo Wigner-Ville distribution) was demonstrated. A major advantage of time-frequency methods is the ability to analyze acoustic signals containing multiple propagation modes, which overlap and superimpose in the time domain signal. By combining time-frequency analysis with a broadband acoustic excitation source, the dispersion of multiple Lamb modes over a wide frequency range can be determined from as little as a single measurement. In addition, the technique provides a direct measurement of the group velocity dispersion. The technique was first demonstrated in the analysis of a simulated waveform in an aluminum plate in which the Lamb mode dispersion was well known. Portions of the dispersion curves of the A(sub 0), A(sub 1), S(sub 0), and S(sub 2)Lamb modes were obtained from this one waveform. The technique was also applied for the analysis of experimental waveforms from a unidirectional graphite/epoxy composite plate. Measurements were made both along, and perpendicular to the fiber direction. In this case, the signals contained only the lowest order symmetric and antisymmetric modes. A least squares fit of the results from several source to detector distances was used. Theoretical dispersion curves were calculated and are shown to be in good agreement with experimental results.

Intertwined and vestigial order with ultracold atoms in multiple cavity modes

NASA Astrophysics Data System (ADS)

Gopalakrishnan, Sarang; Shchadilova, Yulia E.; Demler, Eugene

2017-12-01

Atoms in transversely pumped optical cavities "self-organize" by forming a density wave and emitting superradiantly into the cavity mode(s). For a single-mode cavity, the properties of this self-organization transition are well characterized both theoretically and experimentally. Here, we explore the self-organization of a Bose-Einstein condensate in the presence of two cavity modes—a system that recently was realized experimentally [Léonard et al., Nature (London) 543, 87 (2017), 10.1038/nature21067]. We argue that this system can exhibit a "vestigially ordered" phase in which neither cavity mode exhibits superradiance but the cavity modes are mutually phase locked by the atoms. We argue that this vestigially ordered phase should generically be present in multimode cavity geometries.

Multi-mode of Four and Six Wave Parametric Amplified Process

NASA Astrophysics Data System (ADS)

Zhu, Dayu; Yang, Yiheng; Zhang, Da; Liu, Ruizhou; Ma, Danmeng; Li, Changbiao; Zhang, Yanpeng

2017-03-01

Multiple quantum modes in correlated fields are essential for future quantum information processing and quantum computing. Here we report the generation of multi-mode phenomenon through parametric amplified four- and six-wave mixing processes in a rubidium atomic ensemble. The multi-mode properties in both frequency and spatial domains are studied. On one hand, the multi-mode behavior is dominantly controlled by the intensity of external dressing effect, or nonlinear phase shift through internal dressing effect, in frequency domain; on the other hand, the multi-mode behavior is visually demonstrated from the images of the biphoton fields directly, in spatial domain. Besides, the correlation of the two output fields is also demonstrated in both domains. Our approach supports efficient applications for scalable quantum correlated imaging.

Multi-mode of Four and Six Wave Parametric Amplified Process.

PubMed

Zhu, Dayu; Yang, Yiheng; Zhang, Da; Liu, Ruizhou; Ma, Danmeng; Li, Changbiao; Zhang, Yanpeng

2017-03-03

Multiple quantum modes in correlated fields are essential for future quantum information processing and quantum computing. Here we report the generation of multi-mode phenomenon through parametric amplified four- and six-wave mixing processes in a rubidium atomic ensemble. The multi-mode properties in both frequency and spatial domains are studied. On one hand, the multi-mode behavior is dominantly controlled by the intensity of external dressing effect, or nonlinear phase shift through internal dressing effect, in frequency domain; on the other hand, the multi-mode behavior is visually demonstrated from the images of the biphoton fields directly, in spatial domain. Besides, the correlation of the two output fields is also demonstrated in both domains. Our approach supports efficient applications for scalable quantum correlated imaging.

Local vibrational modes of the water dimer - Comparison of theory and experiment

NASA Astrophysics Data System (ADS)

Kalescky, R.; Zou, W.; Kraka, E.; Cremer, D.

2012-12-01

Local and normal vibrational modes of the water dimer are calculated at the CCSD(T)/CBS level of theory. The local H-bond stretching frequency is 528 cm-1 compared to a normal mode stretching frequency of just 143 cm-1. The adiabatic connection scheme between local and normal vibrational modes reveals that the lowering is due to mass coupling, a change in the anharmonicity, and coupling with the local HOH bending modes. The local mode stretching force constant is related to the strength of the H-bond whereas the normal mode stretching force constant and frequency lead to an erroneous underestimation of the H-bond strength.

How Does Mg2+ Modulate the RNA Folding Mechanism: A Case Study of the G:C W:W Trans Basepair.

PubMed

Halder, Antarip; Roy, Rohit; Bhattacharyya, Dhananjay; Mitra, Abhijit

2017-07-25

Reverse Watson-Crick G:C basepairs (G:C W:W Trans) occur frequently in different functional RNAs. This is one of the few basepairs whose gas-phase-optimized isolated geometry is inconsistent with the corresponding experimental geometry. Several earlier studies indicate that through post-transcriptional modification, direct protonation, or coordination with Mg 2+ , accumulation of positive charge near N7 of guanine can stabilize the experimental geometry. Interestingly, recent studies reveal significant variation in the position of putatively bound Mg 2+ . This, in conjunction with recently raised doubts regarding some of the Mg 2+ assignments near the imino nitrogen of guanine, is suggestive of the existence of multiple Mg 2+ binding modes for this basepair. Our detailed investigation of Mg 2+ -bound G:C W:W Trans pairs occurring in high-resolution RNA crystal structures shows that they are found in 14 different contexts, eight of which display Mg 2+ binding at the Hoogsteen edge of guanine. Further examination of occurrences in these eight contexts led to the characterization of three different Mg 2+ binding modes: 1) direct binding via N7 coordination, 2) direct binding via O6 coordination, and 3) binding via hydrogen-bonding interaction with the first-shell water molecules. In the crystal structures, the latter two modes are associated with a buckled and propeller-twisted geometry of the basepair. Interestingly, respective optimized geometries of these different Mg 2+ binding modes (optimized using six different DFT functionals) are consistent with their corresponding experimental geometries. Subsequent interaction energy calculations at the MP2 level, and decomposition of its components, suggest that for G:C W:W Trans , Mg 2+ binding can fine tune the basepair geometries without compromising with their stability. Our results, therefore, underline the importance of the mode of binding of Mg 2+ ions in shaping RNA structure, folding and function. Copyright © 2017. Published by Elsevier Inc.

A new dynamic model of rotor-blade systems

NASA Astrophysics Data System (ADS)

Ma, Hui; Lu, Yang; Wu, Zhiyuan; Tai, Xingyu; Li, Hui; Wen, Bangchun

2015-11-01

A new dynamic model of rotor-blade systems is developed in this paper considering the lateral and torsional deformations of the shaft, gyroscopic effects of the rotor which consists of shaft and disk, and the centrifugal stiffening, spin softening and Coriolis force of the blades. In this model, the rotating flexible blades are represented by Timoshenko beams. The shaft and rigid disk are described by multiple lumped mass points (LMPs), and these points are connected by massless springs which have both lateral and torsional stiffness. LMPs are represented by the corresponding masses and mass moments of inertia in lateral and rotational directions, where each point has five degrees of freedom (dofs) excluding axial dof. Equations of motion of the rotor-blade system are derived using Hamilton's principle in conjunction with the assumed modes method to describe blade deformation. The proposed model is compared with both finite element (FE) model and real experiments. The proposed model is first validated by comparing the model natural frequencies and vibration responses with those obtained from an FE model. A further verification of the model is then performed by comparing the model natural frequencies at zero rotational speed with those obtained from experimental studies. The results shown a good agreement between the model predicted system characteristics and those obtained from the FE model and experimental tests. Moreover, the following interesting phenomena have been revealed from the new model based analysis: The torsional natural frequency of the system decreases with the increase of rotational speed, and the frequency veering phenomenon has been observed at high rotational speed; The complicated coupling modes, such as the blade-blade coupling mode (BB), the coupling mode between the rotor lateral vibration and blade bending (RBL), and the coupling mode between the rotor torsional vibration and blade bending (RBT), have also been observed when the number of blades increases.

Crystal Structure of the Neutralizing Llama VHH D7 and Its Mode of HIV-1 gp120 Interaction

PubMed Central

Hinz, Andreas; Lutje Hulsik, David; Forsman, Anna; Koh, Willie Wee-Lee; Belrhali, Hassan; Gorlani, Andrea; de Haard, Hans; Weiss, Robin A.; Verrips, Theo; Weissenhorn, Winfried

2010-01-01

HIV-1 entry into host cells is mediated by the sequential binding of the envelope glycoprotein gp120 to CD4 and a chemokine receptor. Antibodies binding to epitopes overlapping the CD4-binding site on gp120 are potent inhibitors of HIV entry, such as the llama heavy chain antibody fragment VHH D7, which has cross-clade neutralizing properties and competes with CD4 and mAb b12 for high affinity binding to gp120. We report the crystal structure of the D7 VHH at 1.5 Å resolution, which reveals the molecular details of the complementarity determining regions (CDR) and substantial flexibility of CDR3 that could facilitate an induced fit interaction with gp120. Structural comparison of CDRs from other CD4 binding site antibodies suggests diverse modes of interaction. Mutational analysis identified CDR3 as a key component of gp120 interaction as determined by surface plasmon resonance. A decrease in affinity is directly coupled to the neutralization efficiency since mutations that decrease gp120 interaction increase the IC50 required for HIV-1 IIIB neutralization. Thus the structural study identifies the long CDR3 of D7 as the key determinant of interaction and HIV-1 neutralization. Furthermore, our data confirm that the structural plasticity of gp120 can accommodate multiple modes of antibody binding within the CD4 binding site. PMID:20463957

Dominant covarying climate signals in the Southern Ocean and Antarctic Sea Ice influence during last three decades

NASA Astrophysics Data System (ADS)

Cerrone, Dario; Fusco, Giannetta; Simmonds, Ian; Aulicino, Giuseppe; Budillon, Giorgio

2017-04-01

A composite dataset (comprising geopotential height, sea surface temperature, zonal and meridional surface winds, precipitation, cloud cover, surface air temperature, latent plus sensible heat fluxes , and sea ice concentration) has been investigated with the aim of revealing the dominant timescales of variability from 1982 to 2013. Three covarying climate signals associated with variations in the sea ice distribution around Antarctica have been detected through the application of the Multiple-Taper Method with Singular Value Decomposition (MTM-SVD). Features of the established patterns of variation over the Southern Hemisphere (SH) extratropics have been identified in each of these three climate signals in the form of coupled or individual oscillations. The climate patterns considered here are the Southern Annular Mode (SAM), the Pacific-South America (PSA) teleconnection, the Semi-Annual Oscillation (SAO) and Zonal Wavenumber-3 (ZW3) mode. It is shown that most of the sea ice temporal variance is concentrated at the quasi-triennial scale resulting from the constructive superposition of the PSA and ZW3 patterns. In addition the combination of the SAM and SAO patterns is found to promote the interannual sea ice variations underlying a general change in the Southern Ocean atmospheric and oceanic circulations. These two modes of variability are also found consistent with the occurrence of the SAM+/PSA- or SAM-/PSA+ combinations, which could have favored the cooling of the sub-Antarctic and important changes in the Antarctic sea ice distribution since 2000.

All optical detection of picosecond spin-wave dynamics in 2D annular antidot lattice

NASA Astrophysics Data System (ADS)

Porwal, Nikita; Mondal, Sucheta; Choudhury, Samiran; De, Anulekha; Sinha, Jaivardhan; Barman, Anjan; Datta, Prasanta Kumar

2018-02-01

Novel magnetic structures with precisely controlled dimensions and shapes at the nanoscale have potential applications in spin logic, spintronics and other spin-based communication devices. We report the fabrication of 2D bi-structure magnonic crystal in the form of embedded nanodots in a periodic Ni80Fe20 antidot lattice structure (annular antidot) by focused ion-beam lithography. The spin-wave spectra of the annular antidot sample, studied for the first time by a time-resolved magneto-optic Kerr effect microscopy show a remarkable variation with bias field, which is important for the above device applications. The optically induced spin-wave spectra show multiple modes in the frequency range 14.7 GHz-3.5 GHz due to collective interactions between the dots and antidots as well as the annular elements within the whole array. Numerical simulations qualitatively reproduce the experimental results, and simulated mode profiles reveal the spatial distribution of the spin-wave modes and internal magnetic fields responsible for these observations. It is observed that the internal field strength increases by about 200 Oe inside each dot embedded within the hole of annular antidot lattice as compared to pure antidot lattice and pure dot lattice. The stray field for the annular antidot lattice is found to be significant (0.8 kOe) as opposed to the negligible values of the same for the pure dot lattice and pure antidot lattice. Our findings open up new possibilities for development of novel artificial crystals.

Microstructure of atmospheric particles revealed by TXM and a new mode of influenza virus transmission

NASA Astrophysics Data System (ADS)

Bao, L. M.; Zhang, G. L.; Lei, Q. T.; Li, Y.; Li, X. L.; Hwu, Y. K.; Yi, J. M.

2015-09-01

For control of influenza, firstly it is important to find the real virus transmission media. Atmospheric aerosol particles are presumably one of the media. In this study, three typical atmospheric inhaled particles in Shanghai were studied by the synchrotron based transmission X-ray microscopes (TXM). Three dimensional microstructure of the particles reveals that there are many pores contained in, particularly the coal combustion fly particles which may be possible virus carrier. The particles can transport over long distance and cause long-range infections due to its light weight. We suggest a mode which is droplet combining with aerosol mode. By this mode the transmission of global and pandemic influenzas and infection between inland avian far from population and poultry or human living in cities along coast may be explained.

Magnon Mode Selective Spin Transport in Compensated Ferrimagnets.

PubMed

Cramer, Joel; Guo, Er-Jia; Geprägs, Stephan; Kehlberger, Andreas; Ivanov, Yurii P; Ganzhorn, Kathrin; Della Coletta, Francesco; Althammer, Matthias; Huebl, Hans; Gross, Rudolf; Kosel, Jürgen; Kläui, Mathias; Goennenwein, Sebastian T B

2017-06-14

We investigate the generation of magnonic thermal spin currents and their mode selective spin transport across interfaces in insulating, compensated ferrimagnet/normal metal bilayer systems. The spin Seebeck effect signal exhibits a nonmonotonic temperature dependence with two sign changes of the detected voltage signals. Using different ferrimagnetic garnets, we demonstrate the universality of the observed complex temperature dependence of the spin Seebeck effect. To understand its origin, we systematically vary the interface between the ferrimagnetic garnet and the metallic layer, and by using different metal layers we establish that interface effects play a dominating role. They do not only modify the magnitude of the spin Seebeck effect signal but in particular also alter its temperature dependence. By varying the temperature, we can select the dominating magnon mode and we analyze our results to reveal the mode selective interface transmission probabilities for different magnon modes and interfaces. The comparison of selected systems reveals semiquantitative details of the interfacial coupling depending on the materials involved, supported by the obtained field dependence of the signal.

Interactions of multiple predators with different foraging modes in an aquatic food web.

PubMed

Carey, Michael P; Wahl, David H

2010-02-01

Top predators can have different foraging modes that may alter their interactions and effects on food webs. Interactions between predators may be non-additive resulting from facilitation or interference, whereas their combined effects on a shared prey may result in emergent effects that are risk enhanced or risk reduced. To test the importance of multiple predators with different foraging modes, we examined the interaction between a cruising predator (largemouth bass, Micropterus salmoides) and an ambush predator (muskellunge, Esox masquinongy) foraging on a shared prey (bluegill sunfish, Lepomis macrochirus) with strong anti-predator defense behaviors. Additive and substitution designs were used to compare individual to combined predator treatments in experimental ponds. The multiple predator interaction facilitated growth of the cruising predator in the combined predator treatments, whereas predator species had substitutable effects on the growth of the ambush predator. The combined predator treatments created an emergent effect on the prey; however, the direction was dependent on the experimental design. The additive design found a risk-reducing effect, whereas the substitution design found a risk-enhancing effect for prey fish. Indirect effects from the predators weakly extended to lower trophic levels (i.e., zooplankton community). Our results highlight the need to consider differences in foraging mode of top predators, interactions between predators, and emergent effects on prey to understand food webs.

Predictive simulation of gait at low gravity reveals skipping as the preferred locomotion strategy

PubMed Central

Ackermann, Marko; van den Bogert, Antonie J.

2012-01-01

The investigation of gait strategies at low gravity environments gained momentum recently as manned missions to the Moon and to Mars are reconsidered. Although reports by astronauts of the Apollo missions indicate alternative gait strategies might be favored on the Moon, computational simulations and experimental investigations have been almost exclusively limited to the study of either walking or running, the locomotion modes preferred under Earth's gravity. In order to investigate the gait strategies likely to be favored at low gravity a series of predictive, computational simulations of gait are performed using a physiological model of the musculoskeletal system, without assuming any particular type of gait. A computationally efficient optimization strategy is utilized allowing for multiple simulations. The results reveal skipping as more efficient and less fatiguing than walking or running and suggest the existence of a walk-skip rather than a walk-run transition at low gravity. The results are expected to serve as a background to the design of experimental investigations of gait under simulated low gravity. PMID:22365845

Predictive simulation of gait at low gravity reveals skipping as the preferred locomotion strategy.

PubMed

Ackermann, Marko; van den Bogert, Antonie J

2012-04-30

The investigation of gait strategies at low gravity environments gained momentum recently as manned missions to the Moon and to Mars are reconsidered. Although reports by astronauts of the Apollo missions indicate alternative gait strategies might be favored on the Moon, computational simulations and experimental investigations have been almost exclusively limited to the study of either walking or running, the locomotion modes preferred under Earth's gravity. In order to investigate the gait strategies likely to be favored at low gravity a series of predictive, computational simulations of gait are performed using a physiological model of the musculoskeletal system, without assuming any particular type of gait. A computationally efficient optimization strategy is utilized allowing for multiple simulations. The results reveal skipping as more efficient and less fatiguing than walking or running and suggest the existence of a walk-skip rather than a walk-run transition at low gravity. The results are expected to serve as a background to the design of experimental investigations of gait under simulated low gravity. Copyright © 2012 Elsevier Ltd. All rights reserved.

Heterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes–Brocks Syndrome

PubMed Central

Webb, Bryn D.; Metikala, Sanjeeva; Wheeler, Patricia G.; Sherpa, Mingma D.; Houten, Sander M.; Horb, Marko E.; Schadt, Eric E.

2017-01-01

A heterozygous nonsense variant was identified in dapper, antagonist of beta-catenin, 1 (DACT1) via whole-exome sequencing in family members with imperforate anus, structural renal abnormalities, genitourinary anomalies, and/or ear anomalies. The DACT1 c.1256G>A;p.Trp419* variant segregated appropriately in the family consistent with an autosomal dominant mode of inheritance. DACT1 is a member of the Wnt-signaling pathway, and mice homozygous for null alleles display multiple congenital anomalies including absent anus with blind-ending colon and genitourinary malformations. To investigate the DACT1 c.1256G>A variant, HEK293 cells were transfected with mutant DACT1 cDNA plasmid, and immunoblotting revealed stability of the DACT1 p.Trp419* protein. Overexpression of DACT1 c.1256G>A mRNA in Xenopus embryos revealed a specific gastrointestinal phenotype of enlargement of the proctodeum. Together, these findings suggest that the DACT1 c.1256G>A nonsense variant is causative of a specific genetic syndrome with features overlapping Townes–Brocks syndrome. PMID:28054444

Heterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes-Brocks Syndrome.

PubMed

Webb, Bryn D; Metikala, Sanjeeva; Wheeler, Patricia G; Sherpa, Mingma D; Houten, Sander M; Horb, Marko E; Schadt, Eric E

2017-04-01

A heterozygous nonsense variant was identified in dapper, antagonist of beta-catenin, 1 (DACT1) via whole-exome sequencing in family members with imperforate anus, structural renal abnormalities, genitourinary anomalies, and/or ear anomalies. The DACT1 c.1256G>A;p.Trp419 * variant segregated appropriately in the family consistent with an autosomal dominant mode of inheritance. DACT1 is a member of the Wnt-signaling pathway, and mice homozygous for null alleles display multiple congenital anomalies including absent anus with blind-ending colon and genitourinary malformations. To investigate the DACT1 c.1256G>A variant, HEK293 cells were transfected with mutant DACT1 cDNA plasmid, and immunoblotting revealed stability of the DACT1 p.Trp419 * protein. Overexpression of DACT1 c.1256G>A mRNA in Xenopus embryos revealed a specific gastrointestinal phenotype of enlargement of the proctodeum. Together, these findings suggest that the DACT1 c.1256G>A nonsense variant is causative of a specific genetic syndrome with features overlapping Townes-Brocks syndrome. © 2017 WILEY PERIODICALS, INC.

Pre-Columbian archaeological ruins are revealed through Costa Rican rain forest in this photo taken during NASA's AirSAR 2004 campaign

NASA Image and Video Library

2004-03-05

Pre-Columbian archaeological ruins are revealed through Costa Rican rain forest in this photo taken during NASA's AirSAR 2004 Mesoamerica campaign. AirSAR 2004 Mesoamerica is a three-week expedition by an international team of scientists that uses an all-weather imaging tool, called the Airborne Synthetic Aperture Radar (AirSAR) which is located onboard NASA's DC-8 airborne laboratory. The radar, developed by NASA's Jet Propulsion Laboratory, can penetrate clouds and also collect data at night. Its high-resolution sensors operate at multiple wavelengths and modes, allowing AirSAR to see beneath treetops, through thin sand, and dry snow pack. Much of the archaeological evidence needed to understand Pre-Columbian societies in Central America comes from features on the landscape. Difficult terrain and logistics have limited ground data collection. AirSAR helped to detect signs of ancient civilizations hidden beneath the forest. Its images will shed insights into the way modern humans interact with their landscape, and how ancient peoples lived and what became of their civilizations.

Microstructures and strain variation: Evidence of multiple splays in the North Almora Thrust Zone, Kumaun Lesser Himalaya, Uttarakhand, India

NASA Astrophysics Data System (ADS)

Joshi, Gaurav; Agarwal, Amar; Agarwal, K. K.; Srivastava, Samriddhi; Alva Valdivia, L. M.

2017-01-01

The North Almora Thrust zone (NATZ) marks the boundary of the Almora Crystalline Complex (ACC) against the Lesser Himalayan Sedimentary sequence (LHS) in the north. Its southern counterpart, the South Almora Thrust (SAT), is a sharply marked contact between the ACC and the LHS in the south. Published studies argue various contradictory emplacement modes of the North Almora Thrust. Recent studies have implied splays of smaller back thrusts in the NATZ. The present study investigates meso- and microstructures, and strain distribution in the NATZ and compares it with strain distribution across the SAT. In the NATZ, field evidence reveals repeated sequence of 10-500 m thick slices of proto- to ultra-mylonite, thrust over the Lesser Himalayan Rautgara quartzite. In accordance with the field evidence, the strain analysis reveals effects of splays of smaller thrust in the NATZ. The study therefore, argues that contrary to popular nomenclature the northern contact of the ACC with the LHS is not a single thrust plane, but a thrust zone marked by numerous thrust splays.

Bonding of contemporary glass ionomer cements to dentin.

PubMed

Yip, H K; Tay, F R; Ngo, H C; Smales, R J; Pashley, D H

2001-09-01

The objective of this study was to investigate the microtensile bond strength (microTBS) of contemporary glass ionomer cements (GIC) to sound coronal dentin. Three specimen teeth were prepared for each material tested: Fuji IX GP (GC), ChemFlex (Dentsply) and Ketac-Molar Aplicap (ESPE). GIC buildups were made according to the manufacturers' instructions. After being stored at 37 degrees C, 100% humidity for 24h, the teeth were vertically sectioned into 1x1mm beams for microTBS evaluation. Representative fractured beams were prepared for scanning (SEM) and transmission electron microscopic (TEM) examination. Results of the microTBS test were: Fuji IX GP (12.4+/-8.6MPa), ChemFlex (15.0+/-9.3MPa) and Ketac-Molar Aplicap (11.4+/-7.7MPa). One-way ANOVA and a multiple comparison test showed that ChemFlex had a statistically higher microTBS (p<0.05). SEM fractographic analysis showed that the predominant failure modes were interfacial and mixed failures. The GIC side of the fractured beams revealed dehydration cracks, a high level of porosity, and voids with an eggshell-like crust. TEM analysis of the demineralized dentin sides of the fractured beams revealed the presence of an intermediate layer along the GIC-dentin interface. This zone was present on the fractured dentin surface in the case of interfacial failure, and beneath GIC remnants in specimens that exhibited a mixed failure mode. The findings suggest that the bonding of GIC to dentin is not weak and that the microTBS values probably represent the weak yield strengths of GICs under tension.

Shape dependent resonant modes of skyrmions in magnetic nanodisks

NASA Astrophysics Data System (ADS)

Liu, Yizhou; Lake, Roger K.; Zang, Jiadong

2018-06-01

Resonant modes of a single Néel type skyrmion in confined nanodisks with varying aspect ratios (AR) are investigated using micromagnetic simulations. The AR of the skyrmion has a non-linear dependence on that of the nanodisk. The power spectra of skyrmions in nanodisks with AR ranging from 1.0 to 2.0 are calculated. With the increase of disk AR, multiple new modes emerge in the power spectrum, which originate from the broken rotational symmetry of both the nanodisk and the skyrmion. All of the spin wave modes are resolved by spatial maps of the real time magnetization fluctuations. New mixed modes such as rotation modes and oscillation modes with different azimuthal and radial components are identified in the elliptical nanodisk with AR = 1.8. The new emergent modes may provide new approaches to skyrmion-based oscillators and spin wave sources in confined structures.

Mode selection in square resonator microlasers for widely tunable single mode lasing.

PubMed

Tang, Ming-Ying; Sui, Shao-Shuai; Yang, Yue-De; Xiao, Jin-Long; Du, Yun; Huang, Yong-Zhen

2015-10-19

Mode selection in square resonator semiconductor microlasers is demonstrated by adjusting the width of the output waveguide coupled to the midpoint of one side. The simulation and experimental results reveal that widely tunable single mode lasing can be realized in square resonator microlasers. Through adjusting the width of the output waveguide, the mode interval of the high-Q modes can reach four times of the longitudinal mode interval. Therefore, mode hopping can be efficiently avoided and the lasing wavelength can be tuned continuously by tuning the injection current. For a 17.8-μm-side-length square microlaser with a 1.4-μm-width output waveguide, mode-hopping-free single-mode operation is achieved with a continuous tuning range of 9.2 nm. As a result, the control of the lasing mode is realized for the square microlasers.

GPR Imaging of Prehistoric Animal Bone-beds

NASA Astrophysics Data System (ADS)

Schneider, Blair Benson

This research investigates the detection capabilities of Ground-penetrating radar for imaging prehistoric animal bone-beds. The first step of this investigation was to determine the dielectric properties of modern animal bone as a proxy for applying non-invasive ground-penetrating radar (GPR) for detecting prehistoric animal remains. Over 90 thin section samples were cut from four different modern faunal skeleton remains: bison, cow, deer, and elk. One sample of prehistoric mammoth core was also analyzed. Sample dielectric properties (relative permittivity, loss factor, and loss-tangent values) were measured with an impedance analyzer over frequencies ranging from 10 MHz to 1 GHz. The results reveal statistically significant dielectric-property differences among different animal fauna, as well as variation as a function of frequency. The measured sample permittivity values were then compared to modeled sample permittivity values using common dielectric-mixing models. The dielectric mixing models were used to report out new reported values of dry bone mineral of 3-5 in the frequency range of 10 MHz to 1 GHz. The second half of this research collected controlled GPR experiments over a sandbox containing buried bison bone elements to evaluate GPR detection capabilities of buried animal bone. The results of the controlled GPR sandbox tests were then compared to numerical models in order to predict the ability of GPR to detect buried animal bone given a variety of different depositional factors, the size and orientation of the bone target and the degree of bone weathering. The radar profiles show that GPR is an effective method for imaging the horizontal and vertical extent of buried animal bone. However, increased bone weathering and increased bone dip were both found to affect GPR reflection signal strength. Finally, the controlled sandbox experiments were also utilized to investigate the impact of survey design for imaging buried animal bone. In particular, the effects of GPR antenna orientation relative to the survey line (broad-side mode versus end-fire mode) and polarization effects of the buried bone targets were investigated. The results reveal that animal bone does exhibit polarization effects. However, the polarization results are greatly affected by the irregular shape and size of the bone, which ultimately limits the potential usefulness of trying to utilize polarization data to determine the orientation of buried bone targets. In regard to antenna orientation, end-fire mode was found to have little difference in amplitude response as compared to the more commonly used broad-side mode and in fact sometimes outperformed the broad-side mode. Future GPR investigations should consider utilizing multiple antenna orientations during data collection.

Reconstruction of the in-plane mode shape of a rotating tire with a continuous scanning measurement using the Hilbert-Huang transform.

PubMed

Lee, Jongsuh; Wang, Semyung; Pluymers, Bert; Desmet, Wim; Kindt, Peter

2015-02-01

Generally, the dynamic characteristics (natural frequency, damping, and mode shape) of a structure can be estimated by experimental modal analysis. Among these dynamic characteristics, mode shape requires multiple measurements of the structure at different positions, which increases the experimental cost and time. Recently, the Hilbert-Huang transform (HHT) method has been introduced to extract mode-shape information from a continuous measurement, which requires vibration measurements from one position to another position continuously with a non-contact sensor. In this research study, an effort has been made to estimate the mode shapes of a rolling tire with a single measurement instead of using the conventional experimental setup (i.e., measurement of the vibration of a rolling tire at multiple positions similar to the case of a non-rotating structure), which is used to estimate the dynamic behavior of a rolling tire. For this purpose, HHT, which was used in the continuous measurement of a non-rotating structure in previous research studies, has been used for the case of a rotating system in this study. Ambiguous mode combinations can occur in this rotating system, and therefore, a method to overcome this ambiguity is proposed in this study. In addition, the specific phenomenon for a rotating system is introduced, and the effect of this phenomenon with regard to the obtained results through HHT is investigated.

Motor imagery learning modulates functional connectivity of multiple brain systems in resting state.

PubMed

Zhang, Hang; Long, Zhiying; Ge, Ruiyang; Xu, Lele; Jin, Zhen; Yao, Li; Liu, Yijun

2014-01-01

Learning motor skills involves subsequent modulation of resting-state functional connectivity in the sensory-motor system. This idea was mostly derived from the investigations on motor execution learning which mainly recruits the processing of sensory-motor information. Behavioral evidences demonstrated that motor skills in our daily lives could be learned through imagery procedures. However, it remains unclear whether the modulation of resting-state functional connectivity also exists in the sensory-motor system after motor imagery learning. We performed a fMRI investigation on motor imagery learning from resting state. Based on previous studies, we identified eight sensory and cognitive resting-state networks (RSNs) corresponding to the brain systems and further explored the functional connectivity of these RSNs through the assessments, connectivity and network strengths before and after the two-week consecutive learning. Two intriguing results were revealed: (1) The sensory RSNs, specifically sensory-motor and lateral visual networks exhibited greater connectivity strengths in precuneus and fusiform gyrus after learning; (2) Decreased network strength induced by learning was proved in the default mode network, a cognitive RSN. These results indicated that resting-state functional connectivity could be modulated by motor imagery learning in multiple brain systems, and such modulation displayed in the sensory-motor, visual and default brain systems may be associated with the establishment of motor schema and the regulation of introspective thought. These findings further revealed the neural substrates underlying motor skill learning and potentially provided new insights into the therapeutic benefits of motor imagery learning.

A geospatial modelling approach to predict seagrass habitat recovery under multiple stressor regimes

EPA Science Inventory

Restoration of estuarine seagrass habitats requires a clear understanding of the modes of action of multiple interacting stressors including nutrients, climate change, coastal land-use change, and habitat modification. We have developed and demonstrated a geospatial modeling a...

Statistical-mechanics theory of active mode locking with noise.

PubMed

Gordon, Ariel; Fischer, Baruch

2004-05-01

Actively mode-locked lasers with noise are studied employing statistical mechanics. A mapping of the system to the spherical model (related to the Ising model) of ferromagnets in one dimension that has an exact solution is established. It gives basic features, such as analytical expressions for the correlation function between modes, and the widths and shapes of the pulses [different from the Kuizenga-Siegman expression; IEEE J. Quantum Electron. QE-6, 803 (1970)] and reveals the susceptibility to noise of mode ordering compared with passive mode locking.

Two antenna, two pass interferometric synthetic aperture radar

DOEpatents

Martinez, Ana; Doerry, Armin W.; Bickel, Douglas L.

2005-06-28

A multi-antenna, multi-pass IFSAR mode utilizing data driven alignment of multiple independent passes can combine the scaling accuracy of a two-antenna, one-pass IFSAR mode with the height-noise performance of a one-antenna, two-pass IFSAR mode. A two-antenna, two-pass IFSAR mode can accurately estimate the larger antenna baseline from the data itself and reduce height-noise, allowing for more accurate information about target ground position locations and heights. The two-antenna, two-pass IFSAR mode can use coarser IFSAR data to estimate the larger antenna baseline. Multi-pass IFSAR can be extended to more than two (2) passes, thereby allowing true three-dimensional radar imaging from stand-off aircraft and satellite platforms.

One Quiz File, Several Modes of Delivery

ERIC Educational Resources Information Center

Herbert, John C.

2012-01-01

This report offers online course designers, particularly those keen on using Moodle CMSs, a means of diversifying accessibility to their educational materials via multiple modes of delivery that do not require the creation of numerous files and formats for just one activity. The author has made contributions to the development of an open source…

Critical Understanding: The Powers and Limits of Pluralism.

ERIC Educational Resources Information Center

Booth, Wayne C.

The problems created by the competing claims of various schools of criticism for a unified view of meaning are examined in this book. Chapters deal with the following topics: the problem of the plurality of modes, Ronald Crane and the pluralism of discrete modes, Kenneth Burke's multiplication of perspectives, history as criticism and the…

Automatic Rejection Of Multimode Laser Pulses

NASA Technical Reports Server (NTRS)

Tratt, David M.; Menzies, Robert T.; Esproles, Carlos

1991-01-01

Characteristic modulation detected, enabling rejection of multimode signals. Monitoring circuit senses multiple longitudinal mode oscillation of transversely excited, atmospheric-pressure (TEA) CO2 laser. Facility developed for inclusion into coherent detection laser radar (LIDAR) system. However, circuit described of use in any experiment where desireable to record data only when laser operates in single longitudinal mode.

Series Connected Buck-Boost Regulator

NASA Technical Reports Server (NTRS)

Birchenough, Arthur G. (Inventor)

2006-01-01

A Series Connected Buck-Boost Regulator (SCBBR) that switches only a fraction of the input power, resulting in relatively high efficiencies. The SCBBR has multiple operating modes including a buck, a boost, and a current limiting mode, so that an output voltage of the SCBBR ranges from below the source voltage to above the source voltage.

Video signal processing system uses gated current mode switches to perform high speed multiplication and digital-to-analog conversion

NASA Technical Reports Server (NTRS)

Gilliland, M. G.; Rougelot, R. S.; Schumaker, R. A.

1966-01-01

Video signal processor uses special-purpose integrated circuits with nonsaturating current mode switching to accept texture and color information from a digital computer in a visual spaceflight simulator and to combine these, for display on color CRT with analog information concerning fading.

Academic In-Sourcing: International Postdoctoral Employment and New Modes of Academic Production

ERIC Educational Resources Information Center

Cantwell, Brendan

2011-01-01

International postdoctoral researchers are growing in number and importance in academic research around the world. This is contextualised by a shift to international and enterprise modes of academic production. Through a multiple case study, this paper analyses the role of international postdoctoral employment in life sciences and engineering…

Multiple Learning Approaches in the Professional Development of School Leaders -- Theoretical Perspectives and Empirical Findings on Self-assessment and Feedback

ERIC Educational Resources Information Center

Huber, Stephan Gerhard

2013-01-01

This article investigates the use of multiple learning approaches and different modes and types of learning in the (continuous) professional development (PD) of school leaders, particularly the use of self-assessment and feedback. First, formats and multiple approaches to professional learning are described. Second, a possible approach to…

Life-Span Extension by Caloric Restriction Is Determined by Type and Level of Food Reduction and by Reproductive Mode in Brachionus manjavacas (Rotifera)

PubMed Central

2013-01-01

We measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%–70% for all three modes, whereas CCR increased life span of asexual females derived from sexually or asexually produced eggs, but not that of sexual females. The main effect of CR on both asexual modes was to delay death at young ages, rather than to prevent death at middle ages or to greatly extend maximum life span; in contrast CR in sexual females greatly increased the life span of a few long-lived individuals. Lifetime fecundity did not decrease with CCR, suggesting a lack of resource allocation trade-off between somatic maintenance and reproduction. Multiple outcomes for a clonal lineage indicate that different responses are established through epigenetic programming, whereas differences in life-span allocations suggest that multiple genetic mechanisms mediate life-span extension. PMID:22904096

A Prescription for List-Mode Data Processing Conventions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beddingfield, David H.; Swinhoe, Martyn Thomas; Huszti, Jozsef

There are a variety of algorithmic approaches available to process list-mode pulse streams to produce multiplicity histograms for subsequent analysis. In the development of the INCC v6.0 code to include the processing of this data format, we have noted inconsistencies in the “processed time” between the various approaches. The processed time, tp, is the time interval over which the recorded pulses are analyzed to construct multiplicity histograms. This is the time interval that is used to convert measured counts into count rates. The observed inconsistencies in tp impact the reported count rate information and the determination of the error-values associatedmore » with the derived singles, doubles, and triples counting rates. This issue is particularly important in low count-rate environments. In this report we will present a prescription for the processing of list-mode counting data that produces values that are both correct and consistent with traditional shift-register technologies. It is our objective to define conventions for list mode data processing to ensure that the results are physically valid and numerically aligned with the results from shift-register electronics.« less

High-energy mode-locked fiber lasers using multiple transmission filters and a genetic algorithm.

PubMed

Fu, Xing; Kutz, J Nathan

2013-03-11

We theoretically demonstrate that in a laser cavity mode-locked by nonlinear polarization rotation (NPR) using sets of waveplates and passive polarizer, the energy performance can be significantly increased by incorporating multiple NPR filters. The NPR filters are engineered so as to mitigate the multi-pulsing instability in the laser cavity which is responsible for limiting the single pulse per round trip energy in a myriad of mode-locked cavities. Engineering of the NPR filters for performance is accomplished by implementing a genetic algorithm that is capable of systematically identifying viable and optimal NPR settings in a vast parameter space. Our study shows that five NPR filters can increase the cavity energy by approximately a factor of five, with additional NPRs contributing little or no enhancements beyond this. With the advent and demonstration of electronic controls for waveplates and polarizers, the analysis suggests a general design and engineering principle that can potentially close the order of magnitude energy gap between fiber based mode-locked lasers and their solid state counterparts.

Life-span extension by caloric restriction is determined by type and level of food reduction and by reproductive mode in Brachionus manjavacas (Rotifera).

PubMed

Gribble, Kristin E; Welch, David B Mark

2013-04-01

We measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%-70% for all three modes, whereas CCR increased life span of asexual females derived from sexually or asexually produced eggs, but not that of sexual females. The main effect of CR on both asexual modes was to delay death at young ages, rather than to prevent death at middle ages or to greatly extend maximum life span; in contrast CR in sexual females greatly increased the life span of a few long-lived individuals. Lifetime fecundity did not decrease with CCR, suggesting a lack of resource allocation trade-off between somatic maintenance and reproduction. Multiple outcomes for a clonal lineage indicate that different responses are established through epigenetic programming, whereas differences in life-span allocations suggest that multiple genetic mechanisms mediate life-span extension.

Multiple-mode nonlinear free and forced vibrations of beams using finite element method

NASA Technical Reports Server (NTRS)

Mei, Chuh; Decha-Umphai, Kamolphan

1987-01-01

Multiple-mode nonlinear free and forced vibration of a beam is analyzed by the finite element method. The geometric nonlinearity is investigated. Inplane displacement and inertia (IDI) are also considered in the formulation. Harmonic force matrix is derived and explained. Nonlinear free vibration can be simply treated as a special case of the general forced vibration by setting the harmonic force matrix equal to zero. The effect of the higher modes is more pronouced for the clamped supported beam than the simply supported one. Beams without IDI yield more effect of the higher modes than the one with IDI. The effects of IDI are to reduce nonlinearity. For beams with end supports restrained from axial movement (immovable cases), only the hardening type nonlinearity is observed. However, beams of small slenderness ratio (L/R = 20) with movable end supports, the softening type nonlinearity is found. The concentrated force case yields a more severe response than the uniformly distributed force case. Finite element results are in good agreement with the solution of simple elliptic response, harmonic balance method, and Runge-Kutte method and experiment.

Transbulbar B-Mode Sonography in Multiple Sclerosis: Clinical and Biological Relevance.

PubMed

De Masi, Roberto; Orlando, Stefania; Conte, Aldo; Pasca, Sergio; Scarpello, Rocco; Spagnolo, Pantaleo; Muscella, Antonella; De Donno, Antonella

2016-12-01

Optic nerve sheath diameter quantification by transbulbar B-mode sonography is a recently validated technique, but its clinical relevance in relapse-free multiple sclerosis patients remains unexplored. In an open-label, comparative, cross-sectional study, we aimed to assess possible differences between patients and healthy controls in terms of optic nerve sheath diameter and its correlation with clinical/paraclinical parameters in this disease. Sixty unselected relapse-free patients and 35 matched healthy controls underwent transbulbar B-mode sonography. Patients underwent routine neurologic examination, brain magnetic resonance imaging and visual evoked potential tests. The mean optic nerve sheath diameter 3 and 5 mm from the eyeball was 22-25% lower in patients than controls and correlated with the Expanded Disability Status Scale (r = -0.34, p = 0.048, and r = -0.32, p = 0.042, respectively). We suggest that optic nerve sheath diameter quantified by transbulbar B-mode sonography should be included in routine assessment of the disease as an extension of the neurologic examination. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Next generation HOM-damping

NASA Astrophysics Data System (ADS)

Marhauser, Frank

2017-06-01

Research and development for superconducting radio-frequency cavities has made enormous progress over the last decades from the understanding of theoretical limitations to the industrial mass fabrication of cavities for large-scale particle accelerators. Key technologies remain hot topics due to continuously growing demands on cavity performance, particularly when in pursuit of high quality beams at higher beam currents or higher luminosities than currently achievable. This relates to higher order mode (HOM) damping requirements. Meeting the desired beam properties implies avoiding coupled multi-bunch or beam break-up instabilities depending on the machine and beam parameters that will set the acceptable cavity impedance thresholds. The use of cavity HOM-dampers is crucial to absorb the wakefields, comprised by all beam-induced cavity Eigenmodes, to beam-dynamically safe levels and to reduce the heat load at cryogenic temperature. Cavity damping concepts may vary, but are principally based on coaxial and waveguide couplers as well as beam line absorbers or any combination. Next generation energy recovery linacs and circular colliders call for cavities with strong HOM-damping that can exceed the state-of-the-art, while the operating mode efficiency shall not be significantly compromised concurrently. This imposes major challenges given the rather limited damping concepts. A detailed survey of established cavities is provided scrutinizing the achieved damping performance, shortcomings, and potential improvements. The scaling of the highest passband mode impedances is numerically evaluated in dependence on the number of cells for a single-cell up to a nine-cell cavity, which reveals the increased probability of trapped modes. This is followed by simulations for single-cell and five-cell cavities, which incorporate multiple damping schemes to assess the most efficient concepts. The usage and viability of on-cell dampers is elucidated for the single-cell cavity since it can push the envelope towards quasi HOM-free operation suited for next generation storage and collider rings. Geometrical end-cell shape alterations for the five-cell cavity with already efficient mode damping are discussed as a possibility to further lower specific high impedance modes. The findings are eventually put into relation with demanding impedance instability thresholds in future collider rings.

Next generation HOM-damping

DOE PAGES

Marhauser, Frank

2017-05-15

Research and development for superconducting radio-frequency cavities has made enormous progress over the last decades from the understanding of theoretical limitations to the industrial mass fabrication of cavities for large-scale particle accelerators. Key technologies remain hot topics due to continuously growing demands on cavity performance, particularly when in pursuit of high quality beams at higher beam currents or higher luminosities than currently achievable. This relates to Higher Order Mode (HOM) damping requirements. Meeting the desired beam properties implies avoiding coupled multi-bunch or beam break-up instabilities depending on the machine and beam parameters that will set the acceptable cavity impedance thresholds.more » The use of cavity HOM-dampers is crucial to absorb the wakefields, comprised by all beam-induced cavity Eigenmodes, to beam-dynamically safe levels and to reduce the heat load at cryogenic temperature. Cavity damping concepts may vary, but are principally based on coaxial and waveguide couplers as well as beam line absorbers or any combination. Next generation Energy Recovery Linacs and circular colliders call for cavities with strong HOM-damping that can exceed the state-of-the-art, while the operating mode efficiency shall not be significantly compromised concurrently. This imposes major challenges given the rather limited damping concepts. A detailed survey of established cavities is provided scrutinizing the achieved damping performance, shortcomings, and potential improvements. The scaling of the highest passband mode impedances is numerically evaluated in dependence on the number of cells for a single-cell up to a nine-cell cavity, which reveals the increased probability of trapped modes. This is followed by simulations for single-cell and five-cell cavities, which incorporate multiple damping schemes to assess the most efficient concepts. The usage and viability of on-cell dampers is elucidated for the single-cell cavity since it can push the envelope towards quasi HOM-free operation suited for next generation storage and collider rings. Geometrical end-cell shape alterations for the five-cell cavity with already efficient mode damping are discussed as a possibility to further lower specific high impedance modes. Lastly, the findings are eventually put into relation with demanding impedance instability thresholds in future collider rings.« less

Optical Absorption and Raman Spectroscopy of Multiple Shocked Liquid Benzene to 10 GPa

NASA Astrophysics Data System (ADS)

Root, S.

2005-07-01

Liquid benzene samples were multiply shocked to peak pressures ranging from 3 GPa to 10 GPa to examine physical and chemical changes in benzene. A xenon flashlamp was used to probe the visible spectrum of benzene for loses in transmitted light intensity caused by changes in the electronic structure (absorption) or a possible liquid to solid phase transition (scattering). Raman spectroscopy was used to corroborate transmission measurements by examining changes in the benzene vibrational modes. The C-C symmetric ring breathing mode (992 cm-1), C-H symmetric stretch (3061 cm-1), along with several weaker modes at 607 cm-1, 1178 cm-1, 1586 cm-1, and 1606 cm-1 were monitored during shock loading. An EOS was developed to calculate the temperature of the shock compressed benzene. The present work has demonstrated that liquid benzene remains unchanged during multiple shock loading up to 10 GPa. Work supported by ONR and DOE.

Scalable entanglement in trapped ions using optimal control of multimode couplings

NASA Astrophysics Data System (ADS)

Debnath, Shantanu; Choi, Taeyoung; Manning, T. Andrew; Figgatt, Caroline; Monroe, Chris

2014-05-01

We perform high fidelity multipartite entanglement of ion subsets in a chain of five Yb+ qubits using optimal pulse shaping. A focused mode-locked laser beam individually addresses qubits to couple them to multiple collective transverse modes of motion to perform entangling phase gates on pairs of adjacent qubits. Pulse shaping by modulating the amplitude and phase of the laser can drive high fidelity gates for certain pulse solutions that are relatively insensitive to detuning errors. We create entangled states in the GHZ class and witness genuine tripartite entanglement using individual state detection. This method of engineering the evolution of multiple modes scales well for large qubit registers by keeping gate times short. This work is supported by grants from the U.S. Army Research Office with funding from the DARPA OLE program, IARPA, and the MURI program; and the NSF Physics Frontier Center at JQI.

Numerical study on a single-mode continuous-wave thermally guiding very-large-mode-area fiber amplifier

NASA Astrophysics Data System (ADS)

Cao, Jianqiu; Liu, Wenbo; Ying, Hanyuan; Chen, Jinbao; Lu, Qisheng

2018-03-01

The characteristics of a single-mode continuous-wave thermally guiding very-large-mode-area fiber amplifier are investigated numerically using the rate-equation model while taking thermal transfer into account. It is revealed that the seed power should play an important role in the fiber amplifier and should be large enough to ensure high output efficiency. The effects of three pumping schemes (i.e. the co-, counter- and bi-directional pumping schemes) and the initial refraction index difference are also studied. It is revealed that the optimum fiber length changes with the pumping scheme, and the initial refraction index difference should be lower than 10-4 in order to ensure the linear increment of the output signal power with the pump power. Furthermore, a brief comparison between the thermally induced waveguides in the fiber amplifiers for three pumping schemes is also made.

Coherent Terahertz Radiation from Multiple Electron Beams Excitation within a Plasmonic Crystal-like structure.

PubMed

Zhang, Yaxin; Zhou, Yucong; Gang, Yin; Jiang, Guili; Yang, Ziqiang

2017-01-23

Coherent terahertz radiation from multiple electron beams excitation within a plasmonic crystal-like structure (a three-dimensional holes array) which is composed of multiple stacked layers with 3 × 3 subwavelength holes array has been proposed in this paper. It has been found that in the structure the electromagnetic fields in each hole can be coupled with one another to construct a composite mode with strong field intensity. Therefore, the multiple electron beams injection can excite and efficiently interact with such mode. Meanwhile, the coupling among the electron beams is taken place during the interaction so that a very strong coherent terahertz radiation with high electron conversion efficiency can be generated. Furthermore, due to the coupling, the starting current density of this mechanism is much lower than that of traditional electron beam-driven terahertz sources. This multi-beam radiation system may provide a favorable way to combine photonics structure with electronics excitation to generate middle, high power terahertz radiation.

Coherent Terahertz Radiation from Multiple Electron Beams Excitation within a Plasmonic Crystal-like structure

PubMed Central

Zhang, Yaxin; Zhou, Yucong; Gang, Yin; Jiang, Guili; Yang, Ziqiang

2017-01-01

Coherent terahertz radiation from multiple electron beams excitation within a plasmonic crystal-like structure (a three-dimensional holes array) which is composed of multiple stacked layers with 3 × 3 subwavelength holes array has been proposed in this paper. It has been found that in the structure the electromagnetic fields in each hole can be coupled with one another to construct a composite mode with strong field intensity. Therefore, the multiple electron beams injection can excite and efficiently interact with such mode. Meanwhile, the coupling among the electron beams is taken place during the interaction so that a very strong coherent terahertz radiation with high electron conversion efficiency can be generated. Furthermore, due to the coupling, the starting current density of this mechanism is much lower than that of traditional electron beam-driven terahertz sources. This multi-beam radiation system may provide a favorable way to combine photonics structure with electronics excitation to generate middle, high power terahertz radiation. PMID:28112234

Monitoring damage growth in titanium matrix composites using acoustic emission

NASA Technical Reports Server (NTRS)

Bakuckas, J. G., Jr.; Prosser, W. H.; Johnson, W. S.

1993-01-01

The application of the acoustic emission (AE) technique to locate and monitor damage growth in titanium matrix composites (TMC) was investigated. Damage growth was studied using several optical techniques including a long focal length, high magnification microscope system with image acquisition capabilities. Fracture surface examinations were conducted using a scanning electron microscope (SEM). The AE technique was used to locate damage based on the arrival times of AE events between two sensors. Using model specimens exhibiting a dominant failure mechanism, correlations were established between the observed damage growth mechanisms and the AE results in terms of the events amplitude. These correlations were used to monitor the damage growth process in laminates exhibiting multiple modes of damage. Results revealed that the AE technique is a viable and effective tool to monitor damage growth in TMC.

In situ X-ray probing reveals fingerprints of surface platinum oxide.

PubMed

Friebel, Daniel; Miller, Daniel J; O'Grady, Christopher P; Anniyev, Toyli; Bargar, John; Bergmann, Uwe; Ogasawara, Hirohito; Wikfeldt, Kjartan Thor; Pettersson, Lars G M; Nilsson, Anders

2011-01-07

In situ X-ray absorption spectroscopy (XAS) at the Pt L(3) edge is a useful probe for Pt-O interactions at polymer electrolyte membrane fuel cell (PEMFC) cathodes. We show that XAS using the high energy resolution fluorescence detection (HERFD) mode, applied to a well-defined monolayer Pt/Rh(111) sample where the bulk penetrating hard X-rays probe only surface Pt atoms, provides a unique sensitivity to structure and chemical bonding at the Pt-electrolyte interface. Ab initio multiple-scattering calculations using the FEFF code and complementary extended X-ray absorption fine structure (EXAFS) results indicate that the commonly observed large increase of the white-line at high electrochemical potentials on PEMFC cathodes originates from platinum oxide formation, whereas previously proposed chemisorbed oxygen-containing species merely give rise to subtle spectral changes.

Exploring hydrocarbon-bearing shale formations with multi-component seismic technology and evaluating direct shear modes produced by vertical-force sources

NASA Astrophysics Data System (ADS)

Alkan, Engin

It is essential to understand natural fracture systems embedded in shale-gas reservoirs and the stress fields that influence how induced fractures form in targeted shale units. Multicomponent seismic technology and elastic seismic stratigraphy allow geologic formations to be better images through analysis of different S-wave modes as well as the P-wave mode. Significant amounts of energy produced by P-wave sources radiate through the Earth as downgoing SV-wave energy. A vertical-force source is an effective source for direct SV radiation and provides a pure shear-wave mode (SV-SV) that should reveal crucial information about geologic surfaces located in anisotropic media. SV-SV shear wave modes should carry important information about petrophysical characteristics of hydrocarbon systems that cannot be obtained using other elastic-wave modes. Regardless of the difficulties of extracting good-quality SV-SV signal, direct shear waves as well as direct P and converted S energy should be accounted for in 3C seismic studies. Acquisition of full-azimuth seismic data and sampling data at small intervals over long offsets are required for detailed anisotropy analysis. If 3C3D data can be acquired with improved signal-to-noise ratio, more uniform illumination of targets, increased lateral resolution, more accurate amplitude attributes, and better multiple attenuation, such data will have strong interest by the industry. The objectives of this research are: (1) determine the feasibility of extracting direct SV-SV common-mid-point sections from 3-C seismic surveys, (2) improve the exploration for stratigraphic traps by developing systematic relationship between petrophysical properties and combinations of P and S wave modes, (3) create compelling examples illustrating how hydrocarbon-bearing reservoirs in low-permeable rocks (particularly anisotropic shale formations) can be better characterized using different Swave modes (P-SV, SV-SV) in addition to the conventional P-P modes, and (4) analyze P and S radiation patterns produced by a variety of seismic sources. The research done in this study has contributed to understanding the physics involved in direct-S radiation from vertical-force source stations. A U.S. Patent issued to the Board of Regents of the University of Texas System now protects the intellectual property the Exploration Geophysics Laboratory has developed related to S-wave generation by vertical-force sources. The University's Office of Technology Commercialization is actively engaged in commercializing this new S-wave reflection seismic technology on behalf of the Board of Regents.

Temperature Histories of Ti-6Al-4V Pulsed-Mode Laser Welds Calculated Using Multiple Constraints

DTIC Science & Technology

2015-08-12

Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/6390--15-9621 Temperature Histories of Ti-6Al-4V Pulsed-Mode Laser Welds Calculated Using...b. ABSTRACT c. THIS PAGE 18. NUMBER OF PAGES 17. LIMITATION OF ABSTRACT Temperature Histories of Ti-6Al-4V Pulsed-Mode Laser Welds Calculated Using...plate structures. The results of the case studies provide parametric representations of weld temperature histories that can be adopted as input data to

On boundaries of ping-pong modes in multipacting

NASA Astrophysics Data System (ADS)

Shemelin, Valery

2018-05-01

Multipactor is an avalanche multiplication of the number of electrons in radio-frequency devices due to secondary electron emission. One of the possible modes of this kind of discharge was studied in detail and was named "a ping-pong mode" in a publication by R. A. Kishek [Phys. Rev. Lett. 108, 035003 (2012) and Phys. Plasmas 20, 056702 (2013)]. In the present paper, I show that conditions of stability and cutoff limits are quite different from those derived in the cited papers.

Understanding Attitudes towards Proenvironmental Travel: An Empirical Study from Tangshan City in China

PubMed Central

Chen, Weiya

2014-01-01

Understanding people's attitudes towards proenvironmental travel will help to encourage people to adopt proenvironmental travel behavior. Revealed preference theory assumes that the consumption preference of consumers can be revealed by their consumption behavior. In order to investigate the influences on citizens' travel decision and analyze the difficulties of promoting proenvironmental travel behavior in medium-sized cities in China, based on revealed preference theory, this paper uses the RP survey method and disaggregate model to analyze how individual characteristics, situational factors, and trip features influence the travel mode choice. The field investigation was conducted in Tangshan City to obtain the RP data. An MNL model was built to deal with the travel mode choice. SPSS software was used to calibrate the model parameters. The goodness-of-fit tests and the predicted outcome demonstrate the validation of the parameter setting. The results show that gender, occupation, trip purpose, and distance have an obvious influence on the travel mode choice. In particular, the male gender, high income, and business travel show a high correlation with carbon-intensive travel, while the female gender and a medium income scored higher in terms of proenvironmental travel modes, such as walking, cycling, and public transport. PMID:25435872

Understanding attitudes towards proenvironmental travel: an empirical study from Tangshan City in China.

PubMed

Fang, Xiaoping; Xu, Yajing; Chen, Weiya

2014-01-01

Understanding people's attitudes towards proenvironmental travel will help to encourage people to adopt proenvironmental travel behavior. Revealed preference theory assumes that the consumption preference of consumers can be revealed by their consumption behavior. In order to investigate the influences on citizens' travel decision and analyze the difficulties of promoting proenvironmental travel behavior in medium-sized cities in China, based on revealed preference theory, this paper uses the RP survey method and disaggregate model to analyze how individual characteristics, situational factors, and trip features influence the travel mode choice. The field investigation was conducted in Tangshan City to obtain the RP data. An MNL model was built to deal with the travel mode choice. SPSS software was used to calibrate the model parameters. The goodness-of-fit tests and the predicted outcome demonstrate the validation of the parameter setting. The results show that gender, occupation, trip purpose, and distance have an obvious influence on the travel mode choice. In particular, the male gender, high income, and business travel show a high correlation with carbon-intensive travel, while the female gender and a medium income scored higher in terms of proenvironmental travel modes, such as walking, cycling, and public transport.

SEM, EDX and Raman and infrared spectroscopic study of brianyoungite Zn3(CO3,SO4)(OH)4 from Esperanza Mine, Laurion District, Greece

NASA Astrophysics Data System (ADS)

Frost, Ray L.; López, Andrés; Wang, Lina; Scholz, Ricardo; Sampaio, Ney Pinheiro

2015-10-01

The mineral brianyoungite, a carbonate-sulphate of zinc, has been studied by scanning electron microscopy (SEM) with chemical analysis using energy dispersive spectroscopy (EDX) and Raman and infrared spectroscopy. Multiple carbonate stretching modes are observed and support the concept of non-equivalent carbonate units in the brianyoungite structure. Intense Raman band at 1056 cm-1 with shoulder band at 1038 cm-1 is assigned to the CO32- ν1 symmetric stretching mode. Two intense Raman bands at 973 and 984 cm-1 are assigned to the symmetric stretching modes of the SO42- anion. The observation of two bands supports the concept of the non-equivalence of sulphate units in the brianyoungite structure. Raman bands at 704 and 736 cm-1 are assigned to the CO32- ν4 bending modes and Raman bands at 507, 528, 609 and 638 cm-1 are assigned to the CO32- ν2 bending modes. Multiple Raman and infrared bands in the OH stretching region are observed, proving the existence of water and hydroxyl units in different molecular environments in the structure of brianyoungite. Vibrational spectroscopy enhances our knowledge of the molecular structure of brianyoungite.

Feedback stabilization of resistive wall modes in a reversed-field pinch

NASA Astrophysics Data System (ADS)

Brunsell, P. R.; Yadikin, D.; Gregoratto, D.; Paccagnella, R.; Liu, Y. Q.; Cecconello, M.; Drake, J. R.; Manduchi, G.; Marchiori, G.

2005-09-01

An array of saddle coils having Nc=16 equally spaced positions along the toroidal direction has been installed for feedback control of resistive wall modes (RWMs) on the EXTRAP T2R reversed-field pinch [P. R. Brunsell, H. Bergsaker, M. Cecconello et al., Plasma Phys. Controlled Fusion 43, 1457 (2001)]. Using feedback, multiple nonresonant RWMs are simultaneously suppressed for three to four wall times. Feedback stabilization of RWMs results in a significant prolongation of the discharge duration. This is linked to a better sustainment of the plasma and tearing mode toroidal rotation with feedback. Due to the limited number of coils in the toroidal direction, pairs of modes with toroidal mode numbers n ,n' that fulfill the condition ∣n-n'∣=Nc are coupled by the feedback action from the discrete coil array. With only one unstable mode in a pair of coupled modes, the suppression of the unstable mode is successful. If two modes are unstable in a coupled pair, two possibilities exist: partial suppression of both modes or, alternatively, complete stabilization of one target mode while the other is left unstable.

Lineshape-asymmetry elimination in weak atomic transitions driven by an intense standing wave field

NASA Astrophysics Data System (ADS)

Antypas, Dionysios; Fabricant, Anne; Budker, Dmitry

2018-05-01

Owing to the ac-Stark effect, the lineshape of a weak optical transition in an atomic beam can become significantly distorted, when driven by an intense standing wave field. We use an Yb atomic beam to study the lineshape of the 6s2 1S0 -> 5d6s 3D1 transition, which is excited with light circulating in a Fabry-Perot resonator. We demonstrate two methods to avoid the distortion of the transition profile. Of these, one relies on the operation of the resonator in multiple longitudinal modes, and the other in multiple transverse modes.

Watching the coherence of multiple vibrational states in organic dye molecules by using supercontinuum probing photon echo spectroscopy

NASA Astrophysics Data System (ADS)

Yu, Guoyang; Song, Yunfei; Wang, Yang; He, Xing; Liu, Yuqiang; Liu, Weilong; Yang, Yanqiang

2011-12-01

A modified photon echo (PE) technique, the supercontinuum probing photon echo (SCPPE), is introduced and performed to investigate the vibrational coherence in organic dye IR780 perchlorate doped polyvinyl alcohol (PVA) film. The coherences of multiple vibrational states which belong to four vibrational modes create complex oscillations in SCPPE signal. The frequencies of vibrational modes are confirmed from the results of Raman calculation which accord fairly well with the results of Raman scattering experiment. Compared with conventional one-color PE, the SCPPE technique can realize broadband detection and make the experiment about vibrational coherence more efficient.

Differential BPFs with Multiple Transmission Zeros Based on Terminated Coupled Lines

NASA Astrophysics Data System (ADS)

Niu, Yiming; Yang, Guo; Wu, Wen

2018-04-01

Differential bandpass filters (BPFs) named Filter A and Filter B based on Terminated Coupled Lines (TCLs) are proposed in this letter. The TCLs contributes to not only three poles in differential-mode (DM) for wideband filtering response but also multiple zeros in both DM and common-mode (CM) offering wide DM out-of-band rejection and good CM suppression. Fabricated filters centred at 3.5 GHz with wide DM passband and wideband CM suppression have been designed and measured. The filters improved the noise suppression capability of the communication and radiometer systems. The simulated and measured results are in good agreement.

Modal survey of the space shuttle solid rocket motor using multiple input methods

NASA Technical Reports Server (NTRS)

Brillhart, Ralph; Hunt, David L.; Jensen, Brent M.; Mason, Donald R.

1987-01-01

The ability to accurately characterize propellant in a finite element model is a concern of engineers tasked with studying the dynamic response of the Space Shuttle Solid Rocket Motor (SRM). THe uncertainties arising from propellant characterization through specimem testing led to the decision to perform a model survey and model correlation of a single segment of the Shuttle SRM. Multiple input methods were used to excite and define case/propellant modes of both an inert segment and, later, a live propellant segment. These tests were successful at defining highly damped, flexible modes, several pairs of which occured with frequency spacing of less than two percent.

Robust partial integrated guidance and control for missiles via extended state observer.

PubMed

Wang, Qing; Ran, Maopeng; Dong, Chaoyang

2016-11-01

A novel extended state observer (ESO) based control is proposed for a class of nonlinear systems subject to multiple uncertainties, and then applied to partial integrated guidance and control (PIGC) design for a missile. The proposed control strategy incorporates both an ESO and an adaptive sliding mode control law. The multiple uncertainties are treated as an extended state of the plant, and then estimate them using the ESO and compensate for them in the control action, in real time. Based on the output of the ESO, the resulting adaptive sliding mode control law is inherently continuous and differentiable. Strict proof is given to show that the estimation error of the ESO can be arbitrarily small in a finite time. In addition, the adaptive sliding mode control law can achieve finite time convergence to a neighborhood of the origin, and the accurate expression of the convergent region is given. Finally, simulations are conducted on the planar missile-target engagement geometry. The effectiveness of the proposed control strategy in enhanced interception performance and improved robustness against multiple uncertainties are demonstrated. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

Simultaneous entanglement swapping of multiple orbital angular momentum states of light.

PubMed

Zhang, Yingwen; Agnew, Megan; Roger, Thomas; Roux, Filippus S; Konrad, Thomas; Faccio, Daniele; Leach, Jonathan; Forbes, Andrew

2017-09-21

High-bit-rate long-distance quantum communication is a proposed technology for future communication networks and relies on high-dimensional quantum entanglement as a core resource. While it is known that spatial modes of light provide an avenue for high-dimensional entanglement, the ability to transport such quantum states robustly over long distances remains challenging. To overcome this, entanglement swapping may be used to generate remote quantum correlations between particles that have not interacted; this is the core ingredient of a quantum repeater, akin to repeaters in optical fibre networks. Here we demonstrate entanglement swapping of multiple orbital angular momentum states of light. Our approach does not distinguish between different anti-symmetric states, and thus entanglement swapping occurs for several thousand pairs of spatial light modes simultaneously. This work represents the first step towards a quantum network for high-dimensional entangled states and provides a test bed for fundamental tests of quantum science.Entanglement swapping in high dimensions requires large numbers of entangled photons and consequently suffers from low photon flux. Here the authors demonstrate entanglement swapping of multiple spatial modes of light simultaneously, without the need for increasing the photon numbers with dimension.

The stability to two-dimensional wakes and shear layers at high Mach numbers

NASA Technical Reports Server (NTRS)

Papageorgiou, Demetrios T.

1991-01-01

This study is concerned with the stability properties of laminar free-shear-layer flows, and in particular symmetric two-dimensional wakes, for the supersonic through the hypersonic regimes. Emphasis is given to the use of proper wake profiles that satisfy the equations of motion at high Reynolds numbers. In particular the inviscid stability of a developing two-dimensional wake is studied as it accelerates at the trailing edge of a splitter plate. The nonparallelism of the flow is a leading-order effect in the calculation of the basic state, which is obtained numerically. Neutral stability characteristics are computed and the hypersonic stability is obtained by increasing the Mach number. It is found that the stability characteristics are altered significantly as the wake develops. Multiple modes (secondary modes) are found in the near wake that are closely related to the corresponding Blasius ones, but as the wake develops mode multiplicity is delayed to higher and higher Mach numbers. At a distance of about one plate length from the trailing edge, there is only one mode in a Mach number range of 0-20. The dominant mode emerging at all wake stations, and for high enough Mach numbers, is the so-called vorticity mode that is centered around the generalized inflection point layer. The structure of the dominant mode is also obtained analytically for all streamwise wake locations and it is shown how the far-wake limit is approached. Asymptotic results for the hypersonic mixing layer given by a tanh and a Lock distribution are also given.

Properties of a novel linear sulfur response mode in a multiple flame photometric detector.

PubMed

Clark, Adrian G; Thurbide, Kevin B

2014-01-24

A new linear sulfur response mode was established in the multiple flame photometric detector (mFPD) by monitoring HSO* emission in the red spectral region above 600nm. Optimal conditions for this mode were found by using a 750nm interference filter and oxygen flows to the worker flames of this device that were about 10mL/min larger than those used for monitoring quadratic S2* emission. By employing these parameters, this mode provided a linear response over about 4 orders of magnitude, with a detection limit near 5.8×10(-11)gS/s and a selectivity of sulfur over carbon of about 3.5×10(3). Specifically, the minimum detectable masses for 10 different sulfur analytes investigated ranged from 0.4 to 3.6ng for peak half-widths spanning 4-6s. The response toward ten different sulfur compounds was examined and produced an average reproducibility of 1.7% RSD (n=10) and an average equimolarity value of 1.0±0.1. In contrast to this, a conventional single flame S2* mode comparatively yielded respective values of 6.7% RSD (n=10) and 1.1±0.4. HSO* emission in the mFPD was also found to be relatively much less affected by response quenching due to hydrocarbons compared to a conventional single flame S2* emission mode. Results indicate that this new alternative linear mFPD response mode could be beneficial for sulfur monitoring applications. Copyright © 2013 Elsevier B.V. All rights reserved.

Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome.

PubMed

Klippel, Stefan; Wieczorek, Marek; Schümann, Michael; Krause, Eberhard; Marg, Berenice; Seidel, Thorsten; Meyer, Tim; Knapp, Ernst-Walter; Freund, Christian

2011-11-04

The high abundance of repetitive but nonidentical proline-rich sequences in spliceosomal proteins raises the question of how these known interaction motifs recruit their interacting protein domains. Whereas complex formation of these adaptors with individual motifs has been studied in great detail, little is known about the binding mode of domains arranged in tandem repeats and long proline-rich sequences including multiple motifs. Here we studied the interaction of the two adjacent WW domains of spliceosomal protein FBP21 with several ligands of different lengths and composition to elucidate the hallmarks of multivalent binding for this class of recognition domains. First, we show that many of the proteins that define the cellular proteome interacting with FBP21-WW1-WW2 contain multiple proline-rich motifs. Among these is the newly identified binding partner SF3B4. Fluorescence resonance energy transfer (FRET) analysis reveals the tandem-WW domains of FBP21 to interact with splicing factor 3B4 (SF3B4) in nuclear speckles where splicing takes place. Isothermal titration calorimetry and NMR shows that the tandem arrangement of WW domains and the multivalency of the proline-rich ligands both contribute to affinity enhancement. However, ligand exchange remains fast compared with the NMR time scale. Surprisingly, a N-terminal spin label attached to a bivalent ligand induces NMR line broadening of signals corresponding to both WW domains of the FBP21-WW1-WW2 protein. This suggests that distinct orientations of the ligand contribute to a delocalized and semispecific binding mode that should facilitate search processes within the spliceosome.

Multivalent Binding of Formin-binding Protein 21 (FBP21)-Tandem-WW Domains Fosters Protein Recognition in the Pre-spliceosome*

PubMed Central

Klippel, Stefan; Wieczorek, Marek; Schümann, Michael; Krause, Eberhard; Marg, Berenice; Seidel, Thorsten; Meyer, Tim; Knapp, Ernst-Walter; Freund, Christian

2011-01-01

The high abundance of repetitive but nonidentical proline-rich sequences in spliceosomal proteins raises the question of how these known interaction motifs recruit their interacting protein domains. Whereas complex formation of these adaptors with individual motifs has been studied in great detail, little is known about the binding mode of domains arranged in tandem repeats and long proline-rich sequences including multiple motifs. Here we studied the interaction of the two adjacent WW domains of spliceosomal protein FBP21 with several ligands of different lengths and composition to elucidate the hallmarks of multivalent binding for this class of recognition domains. First, we show that many of the proteins that define the cellular proteome interacting with FBP21-WW1-WW2 contain multiple proline-rich motifs. Among these is the newly identified binding partner SF3B4. Fluorescence resonance energy transfer (FRET) analysis reveals the tandem-WW domains of FBP21 to interact with splicing factor 3B4 (SF3B4) in nuclear speckles where splicing takes place. Isothermal titration calorimetry and NMR shows that the tandem arrangement of WW domains and the multivalency of the proline-rich ligands both contribute to affinity enhancement. However, ligand exchange remains fast compared with the NMR time scale. Surprisingly, a N-terminal spin label attached to a bivalent ligand induces NMR line broadening of signals corresponding to both WW domains of the FBP21-WW1-WW2 protein. This suggests that distinct orientations of the ligand contribute to a delocalized and semispecific binding mode that should facilitate search processes within the spliceosome. PMID:21917930

Kir Channel Blockages by Proflavine Derivatives via Multiple Modes of Interaction.

PubMed

Inanobe, Atsushi; Itamochi, Hideaki; Kurachi, Yoshihisa

2018-06-01

Many compounds inhibit tetrameric and pseudo-tetrameric cation channels by associating with the central cavity located in the middle of the membrane plane. They traverse the ion conduction pathway from the intracellular side and through access to the cavity. Previously, we reported that the bacteriostatic agent, proflavine, preferentially blocked a subset of inward rectifier K + (Kir) channels. However, the development of the inhibition of Kir1.1 by the compound was obviously different from that operating in Kir3.2 as a pore blocker. To gain mechanistic insights into the compound-channel interaction, we analyzed its chemical specificity, subunit selectivity, and voltage dependency using 13 different combinations of Kir-channel family members and 11 proflavine derivatives. The Kir-channel family members were classified into three groups: 1) Kir2.2, Kir3.x, Kir4.2, and Kir6.2Δ36, which exhibited Kir3.2-type inhibition (slow onset and recovery, irreversible, and voltage-dependent blockage); 2) Kir1.1 and Kir4.1/Kir5.1 (prompt onset and recovery, reversible, and voltage-independent blockage); and 3) Kir2.1, Kir2.3, Kir4.1, and Kir7.1 (no response). The degree of current inhibition depended on the combination of compounds and channels. Chimera between proflavine-sensitive Kir1.1 and -insensitive Kir4.1 revealed that the extracellular portion of Kir1.1 is crucial for the recognition of the proflavine derivative acrinol. In conclusion, preferential blockage of Kir-channel family members by proflavine derivatives is based on multiple modes of action. This raises the possibility of designing subunit-specific inhibitors. Copyright © 2018 by The Author(s).

Robust effects of cloud superparameterization on simulated daily rainfall intensity statistics across multiple versions of the Community Earth System Model

DOE PAGES

Kooperman, Gabriel J.; Pritchard, Michael S.; Burt, Melissa A.; ...

2016-02-01

This study evaluates several important statistics of daily rainfall based on frequency and amount distributions as simulated by a global climate model whose precipitation does not depend on convective parameterization—Super-Parameterized Community Atmosphere Model (SPCAM). Three superparameterized and conventional versions of CAM, coupled within the Community Earth System Model (CESM1 and CCSM4), are compared against two modern rainfall products (GPCP 1DD and TRMM 3B42) to discriminate robust effects of superparameterization that emerge across multiple versions. The geographic pattern of annual-mean rainfall is mostly insensitive to superparameterization, with only slight improvements in the double-ITCZ bias. However, unfolding intensity distributions reveal several improvementsmore » in the character of rainfall simulated by SPCAM. The rainfall rate that delivers the most accumulated rain (i.e., amount mode) is systematically too weak in all versions of CAM relative to TRMM 3B42 and does not improve with horizontal resolution. It is improved by superparameterization though, with higher modes in regions of tropical wave, Madden-Julian Oscillation, and monsoon activity. Superparameterization produces better representations of extreme rates compared to TRMM 3B42, without sensitivity to horizontal resolution seen in CAM. SPCAM produces more dry days over land and fewer over the ocean. Updates to CAM’s low cloud parameterizations have narrowed the frequency peak of light rain, converging toward SPCAM. Poleward of 50°, where more rainfall is produced by resolved-scale processes in CAM, few differences discriminate the rainfall properties of the two models. Lastly, these results are discussed in light of their implication for future rainfall changes in response to climate forcing.« less

HIV health center affiliation networks of black men who have sex with men: disentangling fragmented patterns of HIV prevention service utilization.

PubMed

Schneider, John A; Walsh, Tim; Cornwell, Benjamin; Ostrow, David; Michaels, Stuart; Laumann, Edward O

2012-08-01

In the United States, black men who have sex with men (BMSM) are at highest risk for HIV infection and are at high risk for limited health service utilization. We describe HIV health center (HHC) affiliation network patterns and their potential determinants among urban BMSM. The Men's Assessment of Social and Risk Network instrument was used to elicit HHC utilization, as reported by study respondents recruited through respondent-driven sampling. In 2010, 204 BMSM were systematically recruited from diverse venues in Chicago, IL. A 2-mode data set was constructed that included study participants and 9 diverse HHCs. Associations between individual-level characteristics and HHC utilization were analyzed using Multiple Regression Quadratic Assignment Procedure. Visualization analyses included computation of HHC centrality and faction membership. High utilization of HHCs (45.9%-70.3%) was evident among BMSM, 44.4% who were HIV infected. Multiple Regression Quadratic Assignment Procedure revealed that age, social network size, and HIV status were associated with HHC affiliation patterns (coeff., 0.13-0.27; all P < 0.05). With the exception of one HHC, HHCs offering HIV prevention services to HIV-infected participants occupied peripheral positions within the network of health centers. High-risk HIV-uninfected participants affiliated most with an HHC that offers only treatment services. Subcategories of BMSM in this sample affiliated with HHCs that may not provide appropriate HIV prevention services. Using 2-mode data, public health authorities may be better able to match prevention services to BMSM need; in particular, HIV prevention services for high-risk HIV-uninfected men and HIV "prevention for positives" services for HIV-infected men.

Teacher argumentation in the secondary science classroom: Images of two modes of scientific inquiry

NASA Astrophysics Data System (ADS)

Gray, Ron E.

The purpose of this exploratory study was to examine scientific arguments constructed by secondary science teachers during instruction. The analysis focused on how arguments constructed by teachers differed based on the mode of inquiry underlying the topic. Specifically, how did the structure and content of arguments differ between experimentally and historically based topics? In addition, what factors mediate these differences? Four highly experienced high school science teachers were observed daily during instructional units for both experimental and historical science topics. Data sources include classroom observations, field notes, reflective memos, classroom artifacts, a nature of science survey, and teacher interviews. The arguments were analyzed for structure and content using Toulmin's argumentation pattern and Walton's schemes for presumptive reasoning revealing specific patterns of use between the two modes of inquiry. Interview data was analyzed to determine possible factors mediating these patterns. The results of this study reveal that highly experienced teachers present arguments to their students that, while simple in structure, reveal authentic images of science based on experimental and historical modes of inquiry. Structural analysis of the data revealed a common trend toward a greater amount of scientific data used to evidence knowledge claims in the historical science units. The presumptive reasoning analysis revealed that, while some presumptive reasoning schemes remained stable across the two units (e.g. 'causal inferences' and 'sign' schemes), others revealed different patterns of use including the 'analogy', 'evidence to hypothesis', 'example', and 'expert opinion' schemes. Finally, examination of the interview and survey data revealed five specific factors mediating the arguments constructed by the teachers: view of the nature of science, nature of the topic, teacher personal factors, view of students, and pedagogical decisions. These factors influenced both the structure and use of presumptive reasoning in the arguments. The results have implications for classroom practice, teacher education, and further research.

[Factor structure of regional CBF and CMRglu values as a tool for the study of default mode of the brain].

PubMed

Kataev, G V; Korotkov, A D; Kireev, M V; Medvedev, S V

2013-01-01

In the present article it was shown that the functional connectivity of brain structures, revealed by factor analysis of resting PET CBF and rCMRglu data, is an adequate tool to study the default mode of the human brain. The identification of neuroanatomic systems of default mode (default mode network) during routine clinical PET investigations is important for further studying the functional organization of the normal brain and its reorganizations in pathological conditions.

A model of the transverse modes of stable and unstable porro-prism resonators using symmetry considerations

NASA Astrophysics Data System (ADS)

Burger, Liesl; Forbes, Andrew

2007-09-01

A simple model of a Porro prism laser resonator has been found to correctly predict the formation of the "petal" mode patterns typical of these resonators. A geometrical analysis of the petals suggests that these petals are the lowest-order modes of this type of resonator. Further use of the model reveals the formation of more complex beam patterns, and the nature of these patterns is investigated. Also, the output of stable and unstable resonator modes is presented.

Analytical and experimental vibration studies of a 1/8-scale shuttle orbiter

NASA Technical Reports Server (NTRS)

Pinson, L. D.

1975-01-01

Natural frequencies and mode shapes for four symmetric vibration modes and four antisymmetric modes are compared with predictions based on NASTRAN finite-element analyses. Initial predictions gave poor agreement with test data; an extensive investigation revealed that the major factors influencing agreement were out-of-plane imperfections in fuselage panels and a soft fin-fuselage connection. Computations with a more refined analysis indicated satisfactory frequency predictions for all modes studied, within 11 percent of experimental values.

40 CFR 1066.410 - Dynamometer test procedure.

Code of Federal Regulations, 2014 CFR

2014-07-01

... drive mode. (For purposes of this paragraph (g), the term four-wheel drive includes other multiple drive... Dynamometer test procedure. (a) Dynamometer testing may consist of multiple drive cycles with both cold-start...-setting part identifies the driving schedules and the associated sample intervals, soak periods, engine...

Dynamic modeling and hierarchical compound control of a novel 2-DOF flexible parallel manipulator with multiple actuation modes

NASA Astrophysics Data System (ADS)

Liang, Dong; Song, Yimin; Sun, Tao; Jin, Xueying

2018-03-01

This paper addresses the problem of rigid-flexible coupling dynamic modeling and active control of a novel flexible parallel manipulator (PM) with multiple actuation modes. Firstly, based on the flexible multi-body dynamics theory, the rigid-flexible coupling dynamic model (RFDM) of system is developed by virtue of the augmented Lagrangian multipliers approach. For completeness, the mathematical models of permanent magnet synchronous motor (PMSM) and piezoelectric transducer (PZT) are further established and integrated with the RFDM of mechanical system to formulate the electromechanical coupling dynamic model (ECDM). To achieve the trajectory tracking and vibration suppression, a hierarchical compound control strategy is presented. Within this control strategy, the proportional-differential (PD) feedback controller is employed to realize the trajectory tracking of end-effector, while the strain and strain rate feedback (SSRF) controller is developed to restrain the vibration of the flexible links using PZT. Furthermore, the stability of the control algorithm is demonstrated based on the Lyapunov stability theory. Finally, two simulation case studies are performed to illustrate the effectiveness of the proposed approach. The results indicate that, under the redundant actuation mode, the hierarchical compound control strategy can guarantee the flexible PM achieves singularity-free motion and vibration attenuation within task workspace simultaneously. The systematic methodology proposed in this study can be conveniently extended for the dynamic modeling and efficient controller design of other flexible PMs, especially the emerging ones with multiple actuation modes.

Mime as a Mode of Intelligence.

ERIC Educational Resources Information Center

Shope, Richard

The dramatic art of mime can be viewed through a theory of multiple intelligences. Mime is a mode of the bodily-kinesthetic intelligence which is characterized as the ability to integrate body movement and to use the body in highly differentiated and skilled ways, for expression as well as directed goals. Mime is the language of the body, the…

A Typology of Actional-Operational Modes in Earth Science and Implications for Science Literacy Instruction

ERIC Educational Resources Information Center

Wilson, Amy Alexandra

2013-01-01

Framed in theories of social semiotics, this multiple case study describes and categorizes the actional-operational modes used by three middle school earth science teachers throughout the course of one school year. Data included fieldnotes, photographs, and video recordings of classroom instructions as well as periodic interviews with the…

The Pedagogical Potential of Drawing and Writing in a Primary Science Multimodal Unit

ERIC Educational Resources Information Center

Wilson, Rachel E.; Bradbury, Leslie U.

2016-01-01

In consideration of the potential of drawing and writing as assessment and learning tools, we explored how early primary students used these modes to communicate their science understandings. The context for this study was a curricular unit that incorporated multiple modes of representation in both the presentation of information and production of…

78 FR 76254 - Special Conditions: Airbus, Model A350-900 Series Airplane; Control Surface Awareness and Mode...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-17

... or unusual design features: electronic flight control system providing control surface awareness and... system design must ensure that the flight crew is made suitably aware whenever the primary control means... awareness. 0 b. If the design of the flight control system has multiple modes of operation, a means must be...

Transverse Mode Dynamics and Ultrafast Modulation of Vertical-Cavity Surface-Emitting Lasers

NASA Technical Reports Server (NTRS)

Ning, Cun-Zheng; Biegel, Bryan A. (Technical Monitor)

2002-01-01

We show that multiple transverse mode dynamics of VCSELs (Vertical-Cavity Surface-Emitting Lasers) can be utilized to generate ultrafast intensity modulation at a frequency over 100 GHz, much higher than the relaxation oscillation frequency. Such multimode beating can be greatly enhanced by taking laser output from part of the output facet.

What Do Students Do in a F2F CSCL Classroom? The Optimization of Multiple Communications Modes

ERIC Educational Resources Information Center

Chen, Wenli; Looi, Chee-Kit; Tan, Sini

2010-01-01

This exploratory study analyzes how students use different communication modes to share information, negotiate meaning and construct knowledge in the process of doing a group learning activity in a Primary Grade 5 blended learning environment in Singapore. Small groups of students interacted face-to-face over a computer-mediated communication…

Toward real-time quantum imaging with a single pixel camera

DOE PAGES

Lawrie, B. J.; Pooser, R. C.

2013-03-19

In this paper, we present a workbench for the study of real-time quantum imaging by measuring the frame-by-frame quantum noise reduction of multi-spatial-mode twin beams generated by four wave mixing in Rb vapor. Exploiting the multiple spatial modes of this squeezed light source, we utilize spatial light modulators to selectively pass macropixels of quantum correlated modes from each of the twin beams to a high quantum efficiency balanced detector. Finally, in low-light-level imaging applications, the ability to measure the quantum correlations between individual spatial modes and macropixels of spatial modes with a single pixel camera will facilitate compressive quantum imagingmore » with sensitivity below the photon shot noise limit.« less

Analysis of Motorcycle Weave Mode by using Energy Flow Method

NASA Astrophysics Data System (ADS)

Marumo, Yoshitaka; Katayama, Tsuyoshi

The activation mechanism of motorcycle weave mode is clarified within the framework of the energy flow method, which calculates energy flow of mechanical forces in each motion. It is demonstrated that only a few mechanical forces affect the stability of the weave mode from among a total of about 40 mechanical forces. The activation of the lateral, yawing and rolling motions destabilize the weave mode, while activation of the steering motion stabilizes the weave mode. A detailed investigation of the energy flow of the steering motion reveals that the steering motion plays an important role in clarifying the characteristics of the weave mode. As activation of the steering motion progresses the phase of the front tire side force, and the weave mode is consequently stabilized. This paper provides a design guide for stabilizing the weave mode and the wobble mode compatibility.

Magnon mode selective spin transport in compensated ferrimagnets

DOE PAGES

Cramer, Joel; Guo, Er -Jia; Geprags, Stephan; ...

2017-04-13

We investigate the generation of magnonic thermal spin currents and their mode selective spin transport across interfaces in insulating, compensated ferrimagnet/normal metal bilayer systems. The spin Seebeck effect signal exhibits a nonmonotonic temperature dependence with two sign changes of the detected voltage signals. Using different ferrimagnetic garnets, we demonstrate the universality of the observed complex temperature dependence of the spin Seebeck effect. To understand its origin, we systematically vary the interface between the ferrimagnetic garnet and the metallic layer, and by using different metal layers we establish that interface effects play a dominating role. They do not only modify themore » magnitude of the spin Seebeck effect signal but in particular also alter its temperature dependence. By varying the temperature, we can select the dominating magnon mode and we analyze our results to reveal the mode selective interface transmission probabilities for different magnon modes and interfaces. As a result, the comparison of selected systems reveals semiquantitative details of the interfacial coupling depending on the materials involved, supported by the obtained field dependence of the signal.« less

Magnon mode selective spin transport in compensated ferrimagnets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cramer, Joel; Guo, Er -Jia; Geprags, Stephan

We investigate the generation of magnonic thermal spin currents and their mode selective spin transport across interfaces in insulating, compensated ferrimagnet/normal metal bilayer systems. The spin Seebeck effect signal exhibits a nonmonotonic temperature dependence with two sign changes of the detected voltage signals. Using different ferrimagnetic garnets, we demonstrate the universality of the observed complex temperature dependence of the spin Seebeck effect. To understand its origin, we systematically vary the interface between the ferrimagnetic garnet and the metallic layer, and by using different metal layers we establish that interface effects play a dominating role. They do not only modify themore » magnitude of the spin Seebeck effect signal but in particular also alter its temperature dependence. By varying the temperature, we can select the dominating magnon mode and we analyze our results to reveal the mode selective interface transmission probabilities for different magnon modes and interfaces. As a result, the comparison of selected systems reveals semiquantitative details of the interfacial coupling depending on the materials involved, supported by the obtained field dependence of the signal.« less

Brillouin Study of the Quantization of Acoustic Modes in Nanospheres

NASA Astrophysics Data System (ADS)

Kuok, M. H.; Lim, H. S.; Ng, S. C.; Liu, N. N.; Wang, Z. K.

2003-06-01

The vibrational modes in three-dimensional ordered arrays of unembedded SiO2 nanospheres have been studied by Brillouin light scattering. Multiple distinct Brillouin peaks are observed whose frequencies are found to be inversely proportional to the diameter (≈200 340 nm) of the nanospheres, in agreement with Lamb’s theory. This is the first Brillouin observation of acoustic mode quantization in a nanoparticle arising from spatial confinement. The distinct spectral peaks measured afford an unambiguous assignment of seven surface and inner acoustic modes. Interestingly, the relative intensities and polarization dependence of the Brillouin spectrum do not agree with the predictions made for Raman scattering.

Brillouin study of the quantization of acoustic modes in nanospheres.

PubMed

Kuok, M H; Lim, H S; Ng, S C; Liu, N N; Wang, Z K

2003-06-27

The vibrational modes in three-dimensional ordered arrays of unembedded SiO2 nanospheres have been studied by Brillouin light scattering. Multiple distinct Brillouin peaks are observed whose frequencies are found to be inversely proportional to the diameter (approximately 200-340 nm) of the nanospheres, in agreement with Lamb's theory. This is the first Brillouin observation of acoustic mode quantization in a nanoparticle arising from spatial confinement. The distinct spectral peaks measured afford an unambiguous assignment of seven surface and inner acoustic modes. Interestingly, the relative intensities and polarization dependence of the Brillouin spectrum do not agree with the predictions made for Raman scattering.

Hemispherical breathing mode speaker using a dielectric elastomer actuator.

PubMed

Hosoya, Naoki; Baba, Shun; Maeda, Shingo

2015-10-01

Although indoor acoustic characteristics should ideally be assessed by measuring the reverberation time using a point sound source, a regular polyhedron loudspeaker, which has multiple loudspeakers on a chassis, is typically used. However, such a configuration is not a point sound source if the size of the loudspeaker is large relative to the target sound field. This study investigates a small lightweight loudspeaker using a dielectric elastomer actuator vibrating in the breathing mode (the pulsating mode such as the expansion and contraction of a balloon). Acoustic testing with regard to repeatability, sound pressure, vibration mode profiles, and acoustic radiation patterns indicate that dielectric elastomer loudspeakers may be feasible.

The guided-mode resonance biosensor: principles, technology, and implementation

NASA Astrophysics Data System (ADS)

Magnusson, Robert; Lee, Kyu J.; Hemmati, Hafez; Ko, Yeong Hwan; Wenner, Brett R.; Allen, Jeffery W.; Allen, Monica S.; Gimlin, Susanne; Weidanz, Debra Wawro

2018-02-01

The guided-mode resonance (GMR) sensor operates with quasi-guided modes induced in periodic films. The resonance is enabled by 1D or 2D nanopatterns that are expeditiously fabricated. Optical sensors are needed in many fields including medical diagnostics, chemical analyses, and environmental monitoring. Inducing resonance in multiple modes enables extraction of complete bioreaction information including the biolayer thickness, biolayer refractive index, and any change in the refractive index in the background buffer solution. Thus, we refer to this version of the GMR sensor as the complete biosensor. We address the fundamentals, state of technological development, and implementation of this basic sensor modality.

Quasilinear Line Broadened Model for Energetic Particle Transport

NASA Astrophysics Data System (ADS)

Ghantous, Katy; Gorelenkov, Nikolai; Berk, Herbert

2011-10-01

We present a self-consistent quasi-linear model that describes wave-particle interaction in toroidal geometry and computes fast ion transport during TAE mode evolution. The model bridges the gap between single mode resonances, where it predicts the analytically expected saturation levels, and the case of multiple modes overlapping, where particles diffuse across phase space. Results are presented in the large aspect ratio limit where analytic expressions are used for Fourier harmonics of the power exchange between waves and particles, . Implemention of a more realistic mode structure calculated by NOVAK code are also presented. This work is funded by DOE contract DE-AC02-09CH11466.

Intelligent content fitting for digital publishing

NASA Astrophysics Data System (ADS)

Lin, Xiaofan

2006-02-01

One recurring problem in Variable Data Printing (VDP) is that the existing contents cannot satisfy the VDP task as-is. So there is a strong need for content fitting technologies to support high-value digital publishing applications, in which text and image are the two major types of contents. This paper presents meta-Autocrop framework for image fitting and TextFlex technology for text fitting. The meta-Autocrop framework supports multiple modes: fixed aspect-ratio mode, advice mode, and verification mode. The TextFlex technology supports non-rectangular text wrapping and paragraph-based line breaking. We also demonstrate how these content fitting technologies are utilized in the overall automated composition and layout system.

Method of multi-mode vibration control for the carbody of high-speed electric multiple unit trains

NASA Astrophysics Data System (ADS)

Gong, Dao; Zhou, Jinsong; Sun, Wenjing; Sun, Yu; Xia, Zhanghui

2017-11-01

A method of multi-mode vibration control for the carbody of high-speed electric multiple unit (EMU) trains by using the onboard and suspended equipments as dynamic vibration absorbers (DVAs) is proposed. The effect of the multi-mode vibration on the ride quality of a high-speed EMU train was studied, and the target modes of vibration control were determined. An equivalent mass identification method was used to determine the equivalent mass for the target modes at the device installation positions. To optimize the vibration acceleration response of the carbody, the natural frequencies and damping ratios of the lateral and vertical vibration were designed based on the theory of dynamic vibration absorption. In order to realize the optimized design values of the natural frequencies for the lateral and vertical vibrations simultaneously, a new type of vibration absorber was designed in which a belleville spring and conventional rubber parts are connected in parallel. This design utilizes the negative stiffness of the belleville spring. Results show that, as compared to rigid equipment connections, the proposed method effectively reduces the multi-mode vibration of a carbody in a high-speed EMU train, thereby achieving the control objectives. The ride quality in terms of the lateral and vertical vibration of the carbody is considerably improved. Moreover, the optimal value of the damping ratio is effective in dissipating the vibration energy, which reduces the vibration of both the carbody and the equipment.

Alpha-driven magnetohydrodynamics (MHD) and MHD-induced alpha loss in the Tokamak Fusion Test Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Z.; Nazikian, R.; Fu, G.Y.

1997-02-01

Alpha-driven toroidal Alfven eigenmodes (TAEs) are observed as predicted by theory in the post neutral beam phase in high central q (safety factor) deuterium-tritium (D-T) plasmas in the Tokamak Fusion Test Reactor (TFTR). The mode location, poloidal structure and the importance of q profile for TAE instability are discussed. So far no alpha particle loss due to these modes was detected due to the small mode amplitude. However, alpha loss induced by kinetic ballooning modes (KBMs) was observed in high confinement D-T discharges. Particle orbit simulation demonstrates that the wave-particle resonant interaction can explain the observed correlation between the increasemore » in alpha loss and appearance of multiple high-n (n {ge} 6, n is the toroidal mode number) modes.« less

Manufacturing and testing of wavefront filters for DARWIN

NASA Astrophysics Data System (ADS)

Flatscher, R.; Artjushenko, V.; Sakharova, T.; Pereira do Carmo, Joao

2017-11-01

Wavefront filtering is mandatory in the realisation of nulling interferometers with high star light suppression capability required to detect extrasolar planets, such as the one foreseen for the ESA Darwin mission. This paper presents the design, manufacturing, and test results of single mode fibres to be used as wavefront filters in mid-infrared range. Fibres made from chalcogenide glass and silver halide crystals were produced. The first class can serve as wavefront filters up to a wavelength of 11 microns, while silver halide fibres can be used over the full Darwin wavelength range from 6.5 to 18 micron. The chalcogenide glass fibres were drawn by double crucible method whereas polycrystalline fibres from silver halides were fabricated by multiple extrusion from a crystalline preform. Multi-layer AR-coatings for fibre ends were developed and environmentally tested for both types of fibres. Special fibre facet polishing procedures were established, in particular for the soft silver halide fibre ends. Cable design and assembly process were also developed, including termination by SMA-connectors with ceramic ferrules and fibre protection by loose PEEK-tubings to prevent excessive bending and chemical attacks for fibres. The wavefront filtering capability of the fibres was demonstrated on a high quality Mach-Zehnder interferometer. Two different groups of laser sources were used to measure the wavefront filtering of the fibres by using a CO-laser for testing in the lower sub-band and a CO2-laser to check the upper sub-band. Measurements of the fibres far field intensity distribution and transmission were performed for numerous cable samples. Single mode behaviour was observed in more than 25 silver halide fibre cables before AR-coating of their ends, while after that 17 cables were compliant with all technical requirements. Residual cladding modes existing in short single mode fibres were effectively removed by applying of a proper absorbing jacket to the fibre's lateral surface and by adding an oversized output aperture in front of fibre ends. Several fibres were exposed to gamma radiation of total dose of 25, 50, and even 500 krad. No deterioration was found on AR-coated fibre ends and on fibre material. Five fibres were irradiated by proton radiation of 10MeV energy and 1010 p/cm2 equivalent fluence. Several fibres were cooled down to 10 K by plunging them in a dipstick into liquid Helium. Silver halide fibres survived that test when cables were properly assembled. The brittle chalcogenide glass fibres were much more sensitive to thermal gradients and the related cables did not survive the thermal shock. Critical issues have been revealed in multiple drawings of chalcogenide glass fibres where core and cladding composition were not stable at some fabrication stages - resulting in a poor single mode guiding. Much better results have been achieved with polycrystalline fibres from silver halides made with a small core and low NA and enabling single mode guiding in the mid infrared.

Imaging magnetisation dynamics in nano-contact spin-torque vortex oscillators exhibiting gyrotropic mode splitting

NASA Astrophysics Data System (ADS)

Keatley, Paul Steven; Redjai Sani, Sohrab; Hrkac, Gino; Majid Mohseni, Seyed; Dürrenfeld, Philipp; Åkerman, Johan; Hicken, Robert James

2017-04-01

Nano-contact spin-torque vortex oscillators (STVOs) are anticipated to find application as nanoscale sources of microwave emission in future technological applications. Presently the output power and phase stability of individual STVOs are not competitive with existing oscillator technologies. Synchronisation of multiple nano-contact STVOs via magnetisation dynamics has been proposed to enhance the microwave emission. The control of device-to-device variations, such as mode splitting of the microwave emission, is essential if multiple STVOs are to be successfully synchronised. In this work a combination of electrical measurements and time-resolved scanning Kerr microscopy (TRSKM) was used to demonstrate how mode splitting in the microwave emission of STVOs was related to the magnetisation dynamics that are generated. The free-running STVO response to a DC current only was used to identify devices and bias magnetic field configurations for which single and multiple modes of microwave emission were observed. Stroboscopic Kerr images were acquired by injecting a small amplitude RF current to phase lock the free-running STVO response. The images showed that the magnetisation dynamics of a multimode device with moderate splitting could be controlled by the injected RF current so that they exhibit similar spatial character to that of a single mode. Significant splitting was found to result from a complicated equilibrium magnetic state that was observed in Kerr images as irregular spatial characteristics of the magnetisation dynamics. Such dynamics were observed far from the nano-contact and so their presence cannot be detected in electrical measurements. This work demonstrates that TRSKM is a powerful tool for the direct observation of the magnetisation dynamics generated by STVOs that exhibit complicated microwave emission. Characterisation of such dynamics outside the nano-contact perimeter permits a deeper insight into the requirements for optimal phase-locking of multiple STVOs that share common magnetic layers. , which features invited work from the best early-career researchers working within the scope of J. Phys. D. This project is part of the Journal of Physics series' 50th anniversary celebrations in 2017. Paul Keatley was selected by the Editorial Board of J. Phys. D as an Emerging Leader.

Multiple Intelligences, Motivations and Learning Experience Regarding Video-Assisted Subjects in a Rural University

ERIC Educational Resources Information Center

Hajhashemi, Karim; Caltabiano, Nerina; Anderson, Neil; Tabibzadeh, Seyed Asadollah

2018-01-01

This study investigates multiple intelligences in relation to online video experiences, age, gender, and mode of learning from a rural Australian university. The inter-relationships between learners' different intelligences and their motivations and learning experience with the supplementary online videos utilised in their subjects are…

Characterizing mercury concentrations and flux dynamics in a coastal plain watershed using multiple models

EPA Science Inventory

The primary goal was to asess Hg cycling within a small coastal plain watershed (McTier Creek) using multiple watershed models with distinct mathematical frameworks that emphasize different system dynamics; a secondary goal was to identify current needs in watershed-scale Hg mode...

Obtaining eigensolutions for multiple frequency ranges in a single NASTRAN execution

NASA Technical Reports Server (NTRS)

Pamidi, P. R.; Brown, W. K.

1990-01-01

A novel and general procedure for obtaining eigenvalues and eigenvectors for multiple frequency ranges in a single NASTRAN execution is presented. The scheme is applicable to normal modes analyzes employing the FEER and Inverse Power methods of eigenvalue extraction. The procedure is illustrated by examples.

Advanced online control mode selection for gas turbine aircraft engines

NASA Astrophysics Data System (ADS)

Wiseman, Matthew William

The modern gas turbine aircraft engine is a complex, highly nonlinear system the operates in a widely varying environment. Traditional engine control techniques based on the hydro mechanical control concepts of early turbojet engines are unable to deliver the performance required from today's advanced engine designs. A new type of advanced control utilizing multiple control modes and an online mode selector is investigated, and various strategies for improving the baseline mode selection architecture are introduced. The ability to five-tune actuator command outputs is added to the basic mode selection and blending process, and mode selection designs that we valid for the entire flight envelope are presented. Methods for optimizing the mode selector to improve overall engine performance are also discussed. Finally, using flight test data from a GE F110-powered F16 aircraft, the full-envelope mode selector designs are validated and shown to provide significant performance benefits. Specifically, thrust command tracking is enhanced while critical engine limits are protected, with very little impact on engine efficiency.

Creating Reconfigurable Materials Using ``Colonies'' of Oscillating Polymer Gels

NASA Astrophysics Data System (ADS)

Deb, Debabrata; Dayal, Pratyush; Kuksenok, Olga; Balazs, Anna

2013-03-01

Species ranging from single-cell organisms to social insects can undergo auto-chemotaxis, where the entities move towards a chemo-attractant that they themselves emit. This mode of signaling allows the organisms to form large-scale structures. Using computational modeling, we show that millimeter-sized polymer gels can display similar auto-chemotaxis. In particular, we demonstrate that gels undergoing the self-oscillating Belousov-Zhabotinsky (BZ) reaction not only respond to a chemical signal from the surrounding solution, but also emit this signal and thus, multiple gel pieces can spontaneously self-aggregate. We focus on the collective behavior of ``colonies'' of BZ gels and show that communication between the individual pieces critically depends on all the neighboring gels. We isolate the conditions at which the BZ gels can undergo a type of self-recombining: if a larger gel is cut into distinct pieces that are moved relatively far apart, then their auto-chemotactic behavior drives them to move and autonomously recombine into a structure resembling the original, uncut sample. These findings reveal that the BZ gels can be used as autonomously moving building blocks to construct multiple structures and thus, provide a new route for creating dynamically reconfigurable materials.

A multiple-scattering polaritonic-operator method for hybrid arrays of metal nanoparticles and quantum emitters

NASA Astrophysics Data System (ADS)

Chatzidakis, Georgios D.; Yannopapas, Vassilios

2018-05-01

We present a new technique for the study of hybrid collections of quantum emitters (atoms, molecules, quantum dots) with nanoparticles. The technique is based on a multiple-scattering polaritonic-operator formalism in conjunction with an electromagnetic coupled dipole method. Apart from collections of quantum emitters and nanoparticles, the method can equally treat the interaction of a collection of quantum emitters with a single nano-object of arbitrary shape in which case the nano-object is treated as a finite three-dimensional lattice of point scatterers. We have applied our method to the case of linear array (chain) of dimers of quantum emitters and metallic nanoparticles wherein the corresponding (geometrical and physical) parameters of the dimers are chosen so as the interaction between the emitter and the nanoparticle lies in the strong-coupling regime in order to enable the formation of plexciton states in the dimer. In particular, for a linear chain of dimers, we show that the corresponding light spectra reveal a multitude of plexciton modes resulting from the hybridization of the plexciton resonances of each individual dimer in a manner similar to the tight-binding description of electrons in solids.

[EMD Time-Frequency Analysis of Raman Spectrum and NIR].

PubMed

Zhao, Xiao-yu; Fang, Yi-ming; Tan, Feng; Tong, Liang; Zhai, Zhe

2016-02-01

This paper analyzes the Raman spectrum and Near Infrared Spectrum (NIR) with time-frequency method. The empirical mode decomposition spectrum becomes intrinsic mode functions, which the proportion calculation reveals the Raman spectral energy is uniform distributed in each component, while the NIR's low order intrinsic mode functions only undertakes fewer primary spectroscopic effective information. Both the real spectrum and numerical experiments show that the empirical mode decomposition (EMD) regard Raman spectrum as the amplitude-modulated signal, which possessed with high frequency adsorption property; and EMD regards NIR as the frequency-modulated signal, which could be preferably realized high frequency narrow-band demodulation during first-order intrinsic mode functions. The first-order intrinsic mode functions Hilbert transform reveals that during the period of empirical mode decomposes Raman spectrum, modal aliasing happened. Through further analysis of corn leaf's NIR in time-frequency domain, after EMD, the first and second orders components of low energy are cut off, and reconstruct spectral signal by using the remaining intrinsic mode functions, the root-mean-square error is 1.001 1, and the correlation coefficient is 0.981 3, both of these two indexes indicated higher accuracy in re-construction; the decomposition trend term indicates the absorbency is ascending along with the decreasing to wave length in the near-infrared light wave band; and the Hilbert transform of characteristic modal component displays, 657 cm⁻¹ is the specific frequency by the corn leaf stress spectrum, which could be regarded as characteristic frequency for identification.

Electrophysiological evidence for speech-specific audiovisual integration.

PubMed

Baart, Martijn; Stekelenburg, Jeroen J; Vroomen, Jean

2014-01-01

Lip-read speech is integrated with heard speech at various neural levels. Here, we investigated the extent to which lip-read induced modulations of the auditory N1 and P2 (measured with EEG) are indicative of speech-specific audiovisual integration, and we explored to what extent the ERPs were modulated by phonetic audiovisual congruency. In order to disentangle speech-specific (phonetic) integration from non-speech integration, we used Sine-Wave Speech (SWS) that was perceived as speech by half of the participants (they were in speech-mode), while the other half was in non-speech mode. Results showed that the N1 obtained with audiovisual stimuli peaked earlier than the N1 evoked by auditory-only stimuli. This lip-read induced speeding up of the N1 occurred for listeners in speech and non-speech mode. In contrast, if listeners were in speech-mode, lip-read speech also modulated the auditory P2, but not if listeners were in non-speech mode, thus revealing speech-specific audiovisual binding. Comparing ERPs for phonetically congruent audiovisual stimuli with ERPs for incongruent stimuli revealed an effect of phonetic stimulus congruency that started at ~200 ms after (in)congruence became apparent. Critically, akin to the P2 suppression, congruency effects were only observed if listeners were in speech mode, and not if they were in non-speech mode. Using identical stimuli, we thus confirm that audiovisual binding involves (partially) different neural mechanisms for sound processing in speech and non-speech mode. © 2013 Published by Elsevier Ltd.

Ultrafast vibrational energy flow in water monomers in acetonitrile

NASA Astrophysics Data System (ADS)

Dahms, Fabian; Costard, Rene; Nibbering, Erik T. J.; Elsaesser, Thomas

2016-05-01

Vibrational relaxation of the OH stretching and bending modes of water monomers in acetonitrile is studied by two-color pump-probe experiments in a frequency range from 1400 to 3800 cm-1. Measurements with resonant infrared excitation reveal vibrational lifetimes of 6.4 ± 1.0 ps of the OH stretching modes and 4.0 ± 0.5 ps of the OH bending mode. After OH stretching excitation, the OH bending mode shows an instantaneous response, a hallmark of the anharmonic coupling of stretching and bending modes, and a delayed population buildup by relaxation of the stretching via the bending mode. The relaxation steps are discussed within the framework of current theoretical pictures of water's vibrational relaxation.

Reynolds stress of localized toroidal modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Y.Z.; Mahajan, S.M.

1995-02-01

An investigation of the 2D toroidal eigenmode problem reveals the possibility of a new consistent 2D structure, the dissipative BM-II mode. In contrast to the conventional ballooning mode, the new mode is poloidally localized at {pi}/2 (or -{pi}/2), and possesses significant radial asymmetry. The radial asymmetry, in turn, allows the dissipative BM-II to generate considerably larger Reynolds stress as compared to the standard slab drift type modes. It is also shown that a wide class of localized dissipative toroidal modes are likely to be of the dissipative BM-II nature, suggesting that at the tokamak edge, the fluctuation generated Reynolds stressmore » (a possible source of poloidal flow) can be significant.« less

Scheduling optimization of design stream line for production research and development projects

NASA Astrophysics Data System (ADS)

Liu, Qinming; Geng, Xiuli; Dong, Ming; Lv, Wenyuan; Ye, Chunming

2017-05-01

In a development project, efficient design stream line scheduling is difficult and important owing to large design imprecision and the differences in the skills and skill levels of employees. The relative skill levels of employees are denoted as fuzzy numbers. Multiple execution modes are generated by scheduling different employees for design tasks. An optimization model of a design stream line scheduling problem is proposed with the constraints of multiple executive modes, multi-skilled employees and precedence. The model considers the parallel design of multiple projects, different skills of employees, flexible multi-skilled employees and resource constraints. The objective function is to minimize the duration and tardiness of the project. Moreover, a two-dimensional particle swarm algorithm is used to find the optimal solution. To illustrate the validity of the proposed method, a case is examined in this article, and the results support the feasibility and effectiveness of the proposed model and algorithm.

Influence of multiple ion species on low-frequency electromagnetic wave instabilities. [in solar wind

NASA Technical Reports Server (NTRS)

Brinca, Armando L.; Tsurutani, Bruce T.

1989-01-01

The effect of multiple (singly ionized) coexisting newborn ion species on the stability of low-frequency electromagnetic waves was investigated using a plasma model in which solar wind magnetoplasma is made up of isotropic Maxwellian electron and proton populations with a common number density of 4.95/cu cm and temperatures equal to 17.2 eV and 6.9 eV, respectively. It is shown that the effect of multiple ions on wave growth, for given background magnetoplasma conditions and relative densities, depends not only on their mass but also on the physical nature of the wave modes. If the ion masses are disparate, each one of the coexisting ion beams tends to stimulate instabilities without undue influence from the other species. If the masses of newborn ions are similar, they can strongly catalyze wave growth of fluidlike nonresonant modes, but bring about weak growth enhancements in cyclotron resonant instabilities.

Low-Frequency Interlayer Raman Modes to Probe Interface of Twisted Bilayer MoS 2

DOE PAGES

Huang, Shengxi; Liang, Liangbo; Ling, Xi; ...

2016-02-21

A variety of van der Waals homo- and hetero- structures assembled by stamping monolayers together present optoelectronic properties suitable for diverse applications. Understanding the details of the interlayer stacking and resulting coupling is crucial for tuning these properties. Twisted bilayer transition metal dichalcogenides offer a great platform for developing a precise understanding of the structure/property relationship. Here, we study the low-frequency interlayer shear and breathing Raman modes (<50 cm-1) in twisted bilayer MoS 2 by Raman spectroscopy and first-principles modeling. Twisting introduces both rotational and translational shifts and significantly alters the interlayer stacking and coupling, leading to notable frequency andmore » intensity changes of low-frequency modes. The frequency variation can be up to 8 cm-1 and the intensity can vary by a factor of ~5 for twisting near 0 and 60 , where the stacking is a mixture of multiple high-symmetry stacking patterns and is thus especially sensitive to twisting. Moreover, for twisting angles between 20 and 40 , the interlayer coupling is nearly constant since the stacking results in mismatched lattices over the entire sample. It follows that the Raman signature is relatively uniform. Interestingly, unlike the breathing mode, the shear mode is extremely sensitive to twisting: it disappears between 20 and 40 as its frequency drops to almost zero due to the stacking-induced mismatch. Note that for some samples, multiple breathing mode peaks appear, indicating non-uniform coupling across the interface. In contrast to the low-frequency interlayer modes, high-frequency intralayer Raman modes are much less sensitive to interlayer stacking and coupling, showing negligible changes upon twisting. Our research demonstrates the effectiveness of low-frequency Raman modes for probing the interfacial coupling and environment of twisted bilayer MoS2, and potentially other two-dimensional materials and heterostructures.« less

Nonlinear acoustic spectroscopy of cracked flaws and disbonds: Fundamentals, techniques, and applications

NASA Astrophysics Data System (ADS)

Maev, R. Gr.; Solodov, I. Yu.

2000-05-01

Classical nonlinear acoustics of solids operates with distributed material nonlinearity related to unharmonicity of molecular interaction forces. Weakening of molecular bonds in a defect area or intermittent lack of elastic coupling between the faces of a vibrating crack or unbond ("clapping") results in anomalously high local contact acoustic nonlinearity (CAN). CAN properties and spectral features are different from those of the classical analog and important to develop new acoustic NDE techniques. Three approaches to nonlinear NDE methodology have been experimentally verified: low-frequency (hundreds of Hz) vibration technique, intermediate-frequency (hundreds of kHz) standing wave and high-frequency (tens of MHz) propagation modes. Low-frequency nonlinear contact vibrations revealed multiple sub- and super-harmonics generation featuring non-monotonous (sinx/x type) spectra. Parametric instability observed in resonator with a nonlinear contact leads to the output spectrum splitting up into successive sub-harmonics as the wave amplitude increases. High-frequency experiments demonstrated abnormal increases in the third harmonic amplitude: 3 or 4 order enhancement of the 3-ω nonlinear parameter was measured for the nonlinear contact. The CAN spectral features in both acoustic and vibration modes were used for nonlinear NDE of simulated and realistic flaws in glass, metal welds, etc. The sensitivities of the techniques are compared and their practical applicability assessed.

Fission Meter Information Barrier Attribute Measurement System: Task 1 Report: Document existing Fission Meter neutron IB system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerr, P. L.

An SNM attribute Information Barrier (IB) system was developed for a 2011 US/UK Exercise. The system was modified and extensively tested in a 2013-2014 US-UK Measurement Campaign. This work demonstrated rapid deployment of an IB system for potential treaty use. The system utilizes an Ortec Fission Meter neutron multiplicity counter and custom computer code. The system demonstrates a proof-of-principle automated Pu-240 mass determination with an information barrier. After a software start command is issued, the system automatically acquires and downloads data, performs an analysis, and displays the results. This system conveys the results of a Pu mass threshold measurements inmore » a way the does not reveal sensitive information. In full IB mode, only red/green ‘lights’ are displayed in the software. In test mode, more detailed information is displayed. The code can also read in, analyze, and display results from previously acquired or simulated data. Because the equipment is commercial-off-the-shelf (COTS), the system demonstrates a low-cost short-lead-time technology for treaty SNM attribute measurements. A deployed system will likely require integration of additional authentication and tamper-indicating technologies. This will be discussed for the project in this and future progress reports.« less

Functional Network Development During the First Year: Relative Sequence and Socioeconomic Correlations

PubMed Central

Gao, Wei; Alcauter, Sarael; Elton, Amanda; Hernandez-Castillo, Carlos R.; Smith, J. Keith; Ramirez, Juanita; Lin, Weili

2015-01-01

The first postnatal year is characterized by the most dramatic functional network development of the human lifespan. Yet, the relative sequence of the maturation of different networks and the impact of socioeconomic status (SES) on their development during this critical period remains poorly characterized. Leveraging a large, normally developing infant sample with multiple longitudinal resting-state functional magnetic resonance imaging scans during the first year (N = 65, scanned every 3 months), we aimed to delineate the relative maturation sequence of 9 key brain functional networks and examine their SES correlations. Our results revealed a maturation sequence from primary sensorimotor/auditory to visual to attention/default-mode, and finally to executive control networks. Network-specific critical growth periods were also identified. Finally, marginally significant positive SES–brain correlations were observed at 6 months of age for both the sensorimotor and default-mode networks, indicating interesting SES effects on functional brain maturation. To the best of our knowledge, this is the first study delineating detailed longitudinal growth trajectories of all major functional networks during the first year of life and their SES correlations. Insights from this study not only improve our understanding of early brain development, but may also inform the critical periods for SES expression during infancy. PMID:24812084

Structural-change localization and monitoring through a perturbation-based inverse problem.

PubMed

Roux, Philippe; Guéguen, Philippe; Baillet, Laurent; Hamze, Alaa

2014-11-01

Structural-change detection and characterization, or structural-health monitoring, is generally based on modal analysis, for detection, localization, and quantification of changes in structure. Classical methods combine both variations in frequencies and mode shapes, which require accurate and spatially distributed measurements. In this study, the detection and localization of a local perturbation are assessed by analysis of frequency changes (in the fundamental mode and overtones) that are combined with a perturbation-based linear inverse method and a deconvolution process. This perturbation method is applied first to a bending beam with the change considered as a local perturbation of the Young's modulus, using a one-dimensional finite-element model for modal analysis. Localization is successful, even for extended and multiple changes. In a second step, the method is numerically tested under ambient-noise vibration from the beam support with local changes that are shifted step by step along the beam. The frequency values are revealed using the random decrement technique that is applied to the time-evolving vibrations recorded by one sensor at the free extremity of the beam. Finally, the inversion method is experimentally demonstrated at the laboratory scale with data recorded at the free end of a Plexiglas beam attached to a metallic support.

The network property of the thalamus in the default mode network is correlated with trait mindfulness.

PubMed

Wang, X; Xu, M; Song, Y; Li, X; Zhen, Z; Yang, Z; Liu, J

2014-10-10

Mindfulness is typically defined as nonjudgmental awareness of experiences in the present moment, which is beneficial for mental and physical well-being. Previous studies have identified multiple regions in the default mode network (DMN) that are involved in mindfulness, but little is known about how these regions work collaboratively as a network. Here, we used resting-state functional magnetic resonance imaging to investigate the role of the DMN in trait mindfulness by correlating spontaneous functional connectivity among DMN nodes with self-reported trait mindfulness in a large population of young human adults. Among all pairs of the DMN nodes, we found that individuals with weaker functional connectivity between the thalamus and posterior cingulate cortex (PCC) were more mindful of the present. Post-hoc analyses of these two nodes further revealed that graph-based nodal properties of the thalamus, not the PCC, were negatively correlated with trait mindfulness, suggesting that a low involvement of the thalamus in the DMN is relevant for high trait mindfulness. Our findings not only suggest the thalamus as a switch between mind-wandering and mindfulness, but also invite future studies on mechanisms of how mindfulness produces beneficial effects by modulating the thalamus. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

Paternal Genome Elimination in Liposcelis Booklice (Insecta: Psocodea)

PubMed Central

Hodson, Christina N.; Hamilton, Phineas T.; Dilworth, Dave; Nelson, Chris J.; Curtis, Caitlin I.; Perlman, Steve J.

2017-01-01

How sex is determined in insects is diverse and dynamic, and includes male heterogamety, female heterogamety, and haplodiploidy. In many insect lineages, sex determination is either completely unknown or poorly studied. We studied sex determination in Psocodea—a species-rich order of insects that includes parasitic lice, barklice, and booklice. We focus on a recently discovered species of Liposcelis booklice (Psocodea: Troctomorpha), which are among the closest free-living relatives of parasitic lice. Using genetic, genomic, and immunohistochemical approaches, we show that this group exhibits paternal genome elimination (PGE), an unusual mode of sex determination that involves genomic imprinting. Controlled crosses, following a genetic marker over multiple generations, demonstrated that males only transmit to offspring genes they inherited from their mother. Immunofluorescence microscopy revealed densely packed chromocenters associated with H3K9me3—a conserved marker for heterochromatin—in males, but not in females, suggesting silencing of chromosomes in males. Genome assembly and comparison of read coverage in male and female libraries showed no evidence for differentiated sex chromosomes. We also found that females produce more sons early in life, consistent with facultative sex allocation. It is likely that PGE is widespread in Psocodea, including human lice. This order represents a promising model for studying this enigmatic mode of sex determination. PMID:28292917

Image-driven Population Analysis through Mixture Modeling

PubMed Central

Sabuncu, Mert R.; Balci, Serdar K.; Shenton, Martha E.; Golland, Polina

2009-01-01

We present iCluster, a fast and efficient algorithm that clusters a set of images while co-registering them using a parameterized, nonlinear transformation model. The output of the algorithm is a small number of template images that represent different modes in a population. This is in contrast with traditional, hypothesis-driven computational anatomy approaches that assume a single template to construct an atlas. We derive the algorithm based on a generative model of an image population as a mixture of deformable template images. We validate and explore our method in four experiments. In the first experiment, we use synthetic data to explore the behavior of the algorithm and inform a design choice on parameter settings. In the second experiment, we demonstrate the utility of having multiple atlases for the application of localizing temporal lobe brain structures in a pool of subjects that contains healthy controls and schizophrenia patients. Next, we employ iCluster to partition a data set of 415 whole brain MR volumes of subjects aged 18 through 96 years into three anatomical subgroups. Our analysis suggests that these subgroups mainly correspond to age groups. The templates reveal significant structural differences across these age groups that confirm previous findings in aging research. In the final experiment, we run iCluster on a group of 15 patients with dementia and 15 age-matched healthy controls. The algorithm produces two modes, one of which contains dementia patients only. These results suggest that the algorithm can be used to discover sub-populations that correspond to interesting structural or functional “modes.” PMID:19336293

In-duct identification of a rotating sound source with high spatial resolution

NASA Astrophysics Data System (ADS)

Heo, Yong-Ho; Ih, Jeong-Guon; Bodén, Hans

2015-11-01

To understand and reduce the flow noise generation from in-duct fluid machines, it is necessary to identify the acoustic source characteristics precisely. In this work, a source identification technique, which can identify the strengths and positions of the major sound radiators in the source plane, is studied for an in-duct rotating source. A linear acoustic theory including the effects of evanescent modes and source rotation is formulated based on the modal summation method, which is the underlying theory for the inverse source reconstruction. A validation experiment is conducted on a duct system excited by a loudspeaker in static and rotating conditions, with two different speeds, in the absence of flow. Due to the source rotation, the measured pressure spectra reveal the Doppler effect, and the amount of frequency shift corresponds to the multiplication of the circumferential mode order and the rotation speed. Amplitudes of participating modes are estimated at the shifted frequencies in the stationary reference frame, and the modal amplitude set including the effect of source rotation is collected to investigate the source behavior in the rotating reference frame. By using the estimated modal amplitudes, the near-field pressure is re-calculated and compared with the measured pressure. The obtained maximum relative error is about -25 and -10 dB for rotation speeds at 300 and 600 rev/min, respectively. The spatial distribution of acoustic source parameters is restored from the estimated modal amplitude set. The result clearly shows that the position and magnitude of the main sound source can be identified with high spatial resolution in the rotating reference frame.

Observation of non-Hermitian degeneracies in a chaotic exciton-polariton billiard.

PubMed

Gao, T; Estrecho, E; Bliokh, K Y; Liew, T C H; Fraser, M D; Brodbeck, S; Kamp, M; Schneider, C; Höfling, S; Yamamoto, Y; Nori, F; Kivshar, Y S; Truscott, A G; Dall, R G; Ostrovskaya, E A

2015-10-22

Exciton-polaritons are hybrid light-matter quasiparticles formed by strongly interacting photons and excitons (electron-hole pairs) in semiconductor microcavities. They have emerged as a robust solid-state platform for next-generation optoelectronic applications as well as for fundamental studies of quantum many-body physics. Importantly, exciton-polaritons are a profoundly open (that is, non-Hermitian) quantum system, which requires constant pumping of energy and continuously decays, releasing coherent radiation. Thus, the exciton-polaritons always exist in a balanced potential landscape of gain and loss. However, the inherent non-Hermitian nature of this potential has so far been largely ignored in exciton-polariton physics. Here we demonstrate that non-Hermiticity dramatically modifies the structure of modes and spectral degeneracies in exciton-polariton systems, and, therefore, will affect their quantum transport, localization and dynamical properties. Using a spatially structured optical pump, we create a chaotic exciton-polariton billiard--a two-dimensional area enclosed by a curved potential barrier. Eigenmodes of this billiard exhibit multiple non-Hermitian spectral degeneracies, known as exceptional points. Such points can cause remarkable wave phenomena, such as unidirectional transport, anomalous lasing/absorption and chiral modes. By varying parameters of the billiard, we observe crossing and anti-crossing of energy levels and reveal the non-trivial topological modal structure exclusive to non-Hermitian systems. We also observe mode switching and a topological Berry phase for a parameter loop encircling the exceptional point. Our findings pave the way to studies of non-Hermitian quantum dynamics of exciton-polaritons, which may uncover novel operating principles for polariton-based devices.

Altered Intrinsic Functional Brain Architecture in Children at Familial Risk of Major Depression.

PubMed

Chai, Xiaoqian J; Hirshfeld-Becker, Dina; Biederman, Joseph; Uchida, Mai; Doehrmann, Oliver; Leonard, Julia A; Salvatore, John; Kenworthy, Tara; Brown, Ariel; Kagan, Elana; de Los Angeles, Carlo; Gabrieli, John D E; Whitfield-Gabrieli, Susan

2016-12-01

Neuroimaging studies of patients with major depression have revealed abnormal intrinsic functional connectivity measured during the resting state in multiple distributed networks. However, it is unclear whether these findings reflect the state of major depression or reflect trait neurobiological underpinnings of risk for major depression. We compared resting-state functional connectivity, measured with functional magnetic resonance imaging, between unaffected children of parents who had documented histories of major depression (at-risk, n = 27; 8-14 years of age) and age-matched children of parents with no lifetime history of depression (control subjects, n = 16). At-risk children exhibited hyperconnectivity between the default mode network and subgenual anterior cingulate cortex/orbital frontal cortex, and the magnitude of connectivity positively correlated with individual symptom scores. At-risk children also exhibited 1) hypoconnectivity within the cognitive control network, which also lacked the typical anticorrelation with the default mode network; 2) hypoconnectivity between left dorsolateral prefrontal cortex and subgenual anterior cingulate cortex; and 3) hyperconnectivity between the right amygdala and right inferior frontal gyrus, a key region for top-down modulation of emotion. Classification between at-risk children and control subjects based on resting-state connectivity yielded high accuracy with high sensitivity and specificity that was superior to clinical rating scales. Children at familial risk for depression exhibited atypical functional connectivity in the default mode, cognitive control, and affective networks. Such task-independent functional brain measures of risk for depression in children could be used to promote early intervention to reduce the likelihood of developing depression. Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Nonlinear coupled mode approach for modeling counterpropagating solitons in the presence of disorder-induced multiple scattering in photonic crystal waveguides

NASA Astrophysics Data System (ADS)

Mann, Nishan; Hughes, Stephen

2018-02-01

We present the analytical and numerical details behind our recently published article [Phys. Rev. Lett. 118, 253901 (2017), 10.1103/PhysRevLett.118.253901], describing the impact of disorder-induced multiple scattering on counterpropagating solitons in photonic crystal waveguides. Unlike current nonlinear approaches using the coupled mode formalism, we account for the effects of intraunit cell multiple scattering. To solve the resulting system of coupled semilinear partial differential equations, we introduce a modified Crank-Nicolson-type norm-preserving implicit finite difference scheme inspired by the transfer matrix method. We provide estimates of the numerical dispersion characteristics of our scheme so that optimal step sizes can be chosen to either minimize numerical dispersion or to mimic the exact dispersion. We then show numerical results of a fundamental soliton propagating in the presence of multiple scattering to demonstrate that choosing a subunit cell spatial step size is critical in accurately capturing the effects of multiple scattering, and illustrate the stochastic nature of disorder by simulating soliton propagation in various instances of disordered photonic crystal waveguides. Our approach is easily extended to include a wide range of optical nonlinearities and is applicable to various photonic nanostructures where power propagation is bidirectional, either by choice, or as a result of multiple scattering.

Nuclear resonance vibrational spectroscopy reveals the FeS cluster composition and active site vibrational properties of an O 2-tolerant NAD +-reducing [NiFe] hydrogenase

DOE PAGES

Lauterbach, Lars; Wang, Hongxin; Horch, Marius; ...

2014-10-30

Hydrogenases are complex metalloenzymes that catalyze the reversible splitting of molecular hydrogen into protons and electrons essentially without overpotential. The NAD+-reducing soluble hydrogenase (SH) from Ralstonia eutropha is capable of H 2 conversion even in the presence of usually toxic dioxygen. The molecular details of the underlying reactions are largely unknown, mainly because of limited knowledge of the structure and function of the various metal cofactors present in the enzyme. Here, all iron-containing cofactors of the SH were investigated by 57Fe specific nuclear resonance vibrational spectroscopy (NRVS). Our data provide experimental evidence for one [2Fe2S] center and four [4Fe4S] clusters,more » which is consistent with the amino acid sequence composition. Only the [2Fe2S] cluster and one of the four [4Fe4S] clusters were reduced upon incubation of the SH with NADH. This finding explains the discrepancy between the large number of FeS clusters and the small amount of FeS cluster-related signals as detected by electron paramagnetic resonance spectroscopic analysis of several NAD+-reducing hydrogenases. For the first time, Fe–CO and Fe–CN modes derived from the [NiFe] active site could be distinguished by NRVS through selective 13C labeling of the CO ligand. This strategy also revealed the molecular coordinates that dominate the individual Fe–CO modes. The present approach explores the complex vibrational signature of the Fe–S clusters and the hydrogenase active site, thereby showing that NRVS represents a powerful tool for the elucidation of complex biocatalysts containing multiple cofactors.« less

Nuclear resonance vibrational spectroscopy reveals the FeS cluster composition and active site vibrational properties of an O2-tolerant NAD+-reducing [NiFe] hydrogenase.

PubMed

Lauterbach, Lars; Wang, Hongxin; Horch, Marius; Gee, Leland B; Yoda, Yoshitaka; Tanaka, Yoshihito; Zebger, Ingo; Lenz, Oliver; Cramer, Stephen P

Hydrogenases are complex metalloenzymes that catalyze the reversible splitting of molecular hydrogen into protons and electrons essentially without overpotential. The NAD + -reducing soluble hydrogenase (SH) from Ralstonia eutropha is capable of H 2 conversion even in the presence of usually toxic dioxygen. The molecular details of the underlying reactions are largely unknown, mainly because of limited knowledge of the structure and function the various metal cofactors present in the enzyme. Here all iron-containing cofactors of the SH were investigated by 57 Fe specific nuclear resonance vibrational spectroscopy (NRVS). Our data provide experimental evidence for one [2Fe2S] center and four [4Fe4S] clusters, which is consistent with amino acid sequence composition. Only the [2Fe2S] cluster and one of the four [4Fe4S] clusters were reduced upon incubation of the SH with NADH. This finding explains the discrepancy between the large number of FeS clusters and the small amount of FeS cluster-related signals as detected by electron paramagnetic resonance spectroscopic analysis of several NAD + -reducing hydrogenases. For the first time, Fe-CO and Fe-CN modes derived from the [NiFe] active site could be distinguished by NRVS through selective 13 C labeling of the CO ligand. This strategy also revealed the molecular coordinates that dominate the individual Fe-CO modes. The present approach explores the complex vibrational signature of the Fe-S clusters and the hydrogenase active site, thereby showing that NRVS represents a powerful tool for the elucidation of complex biocatalysts containing multiple cofactors.

Construction of the first compendium of chemical-genetic profiles in the fission yeast Schizosaccharomyces pombe and comparative compendium approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Han, Sangjo; Lee, Minho; Chang, Hyeshik

Highlights: •The first compendium of chemical-genetic profiles form fission yeast was generated. •The first HTS of drug mode-of-action in fission yeast was performed. •The first comparative chemical genetic analysis between two yeasts was conducted. -- Abstract: Genome-wide chemical genetic profiles in Saccharomyces cerevisiae since the budding yeast deletion library construction have been successfully used to reveal unknown mode-of-actions of drugs. Here, we introduce comparative approach to infer drug target proteins more accurately using two compendiums of chemical-genetic profiles from the budding yeast S. cerevisiae and the fission yeast Schizosaccharomyces pombe. For the first time, we established DNA-chip based growth defectmore » measurement of genome-wide deletion strains of S. pombe, and then applied 47 drugs to the pooled heterozygous deletion strains to generate chemical-genetic profiles in S. pombe. In our approach, putative drug targets were inferred from strains hypersensitive to given drugs by analyzing S. pombe and S. cerevisiae compendiums. Notably, many evidences in the literature revealed that the inferred target genes of fungicide and bactericide identified by such comparative approach are in fact the direct targets. Furthermore, by filtering out the genes with no essentiality, the multi-drug sensitivity genes, and the genes with less eukaryotic conservation, we created a set of drug target gene candidates that are expected to be directly affected by a given drug in human cells. Our study demonstrated that it is highly beneficial to construct the multiple compendiums of chemical genetic profiles using many different species. The fission yeast chemical-genetic compendium is available at (http://pombe.kaist.ac.kr/compendium)« less

Sample distribution in peak mode isotachophoresis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rubin, Shimon; Schwartz, Ortal; Bercovici, Moran, E-mail: mberco@technion.ac.il

We present an analytical study of peak mode isotachophoresis (ITP), and provide closed form solutions for sample distribution and electric field, as well as for leading-, trailing-, and counter-ion concentration profiles. Importantly, the solution we present is valid not only for the case of fully ionized species, but also for systems of weak electrolytes which better represent real buffer systems and for multivalent analytes such as proteins and DNA. The model reveals two major scales which govern the electric field and buffer distributions, and an additional length scale governing analyte distribution. Using well-controlled experiments, and numerical simulations, we verify andmore » validate the model and highlight its key merits as well as its limitations. We demonstrate the use of the model for determining the peak concentration of focused sample based on known buffer and analyte properties, and show it differs significantly from commonly used approximations based on the interface width alone. We further apply our model for studying reactions between multiple species having different effective mobilities yet co-focused at a single ITP interface. We find a closed form expression for an effective-on rate which depends on reactants distributions, and derive the conditions for optimizing such reactions. Interestingly, the model reveals that maximum reaction rate is not necessarily obtained when the concentration profiles of the reacting species perfectly overlap. In addition to the exact solutions, we derive throughout several closed form engineering approximations which are based on elementary functions and are simple to implement, yet maintain the interplay between the important scales. Both the exact and approximate solutions provide insight into sample focusing and can be used to design and optimize ITP-based assays.« less