Thirty years of research and development of air cushion vehicles

NASA Astrophysics Data System (ADS)

Bertelsen, William R.

This paper describes the conception of the air cushion vehicle (ACV) from experiments with the ground effect of a VTOL aircraft model. Then it describes the evolution of the ultimate ACV drive system through building and testing many models and 16 full-scale ACV to arrive at complete controllability. Adequate control of the frictionless craft, which are without inherent yaw stability, requires control force of the order of magnitude of propulsion. The derived gimbal fans provide such control force in the form of direct thrust, which is instantly available in any of 360 degrees, meterable, instantly cancelable, and reversible.

Intratumoral heterogeneity of the epigenome

PubMed Central

Song, Jun S.; Costello, Joseph F.

2016-01-01

Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage. The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably similar, suggesting widespread co-dependency of these disparate mechanisms. The biological and clinical relevance of epigenetic ITH are becoming more apparent. Rare tumor cells with unique and reversible epigenetic states may drive drug resistance, and the degree of epigenetic ITH at diagnosis may predict patient outcome. This perspective presents these current concepts and clinical implications of epigenetic ITH, and the experimental and computational techniques at the forefront of ITH exploration. PMID:27070699

Generalized speed and cost rate in transitionless quantum driving

NASA Astrophysics Data System (ADS)

Xu, Zhen-Yu; You, Wen-Long; Dong, Yu-Li; Zhang, Chengjie; Yang, W. L.

2018-03-01

Transitionless quantum driving, also known as counterdiabatic driving, is a unique shortcut technique to adiabaticity, enabling a fast-forward evolution to the same target quantum states as those in the adiabatic case. However, as nothing is free, the fast evolution is obtained at the cost of stronger driving fields. Here, given the system initially gets prepared in equilibrium states, we construct relations between the dynamical evolution speed and the cost rate of transitionless quantum driving in two scenarios: one that preserves the transitionless evolution for a single energy eigenstate (individual driving), and the other that maintains all energy eigenstates evolving transitionlessly (collective driving). Remarkably, we find that individual driving may cost as much as collective driving, in contrast to the common belief that individual driving is more economical than collective driving in multilevel systems. We then present a potentially practical proposal to demonstrate the above phenomena in a three-level Landau-Zener model using the electronic spin system of a single nitrogen-vacancy center in diamond.

Pulse-burst laser systems for fast Thomson scattering (invited)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Den Hartog, D. J.; Center for Magnetic Self-Organization in Laboratory and Astrophysical Plasmas, University of Wisconsin-Madison, Madison, Wisconsin 53706; Ambuel, J. R.

2010-10-15

Two standard commercial flashlamp-pumped Nd:YAG (YAG denotes yttrium aluminum garnet) lasers have been upgraded to ''pulse-burst'' capability. Each laser produces a burst of up to 15 2 J Q-switched pulses (1064 nm) at repetition rates of 1-12.5 kHz. Variable pulse-width drive (0.15-0.39 ms) of the flashlamps is accomplished by insulated gate bipolar transistor (IGBT) switching of electrolytic capacitor banks. Direct control of the laser Pockels cell drive enables optimal pulse energy extraction, and up to four 2 J laser pulses during one flashlamp pulse. These lasers are used in the Thomson scattering plasma diagnostic system on the MST reversed-field pinchmore » to record the dynamic evolution of the electron temperature profile and temperature fluctuations. To further these investigations, a custom pulse-burst laser system with a maximum pulse repetition rate of 250 kHz is now being commissioned.« less

Equilibrium evolution in oscillating-field current-drive experiments

NASA Astrophysics Data System (ADS)

McCollam, K. J.; Anderson, J. K.; Blair, A. P.; Craig, D.; Den Hartog, D. J.; Ebrahimi, F.; O'Connell, R.; Reusch, J. A.; Sarff, J. S.; Stephens, H. D.; Stone, D. R.; Brower, D. L.; Deng, B. H.; Ding, W. X.

2010-08-01

Oscillating-field current drive (OFCD) is a proposed method of steady-state toroidal plasma sustainment in which ac poloidal and toroidal loop voltages are applied to produce a dc plasma current. OFCD is added to standard, inductively sustained reversed-field pinch plasmas in the Madison Symmetric Torus [R. N. Dexter et al., Fusion Technol. 19, 131 (1991)]. Equilibrium profiles and fluctuations during a single cycle are measured and analyzed for different relative phases between the two OFCD voltages and for OFCD off. For OFCD phases leading to the most added plasma current, the measured energy confinement is slightly better than that for OFCD off. By contrast, the phase of the maximum OFCD helicity-injection rate also has the maximum decay rate, which is ascribed to transport losses during discrete magnetic-fluctuation events induced by OFCD. Resistive-magnetohydrodynamic simulations of the experiments reproduce the observed phase dependence of the added current.

In Situ Stress Evolution in Li 1+x Mn 2 O 4 Thin Films during Electrochemical Cycling in Li-Ion Cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheth, Jay; Karan, Naba K.; Abraham, Daniel P.

2016-01-01

Real time monitoring of stress evolution in electrodes during electrochemical cycling can help quantify the driving forces that dictate their mechanical degradation. In the present work, in-situ stress evolution in thin films of spinel Li 1+x Mn 2 O 4 (LMO) was measured by monitoring the change in the elastic substrate curvature during electrochemical cycling in a specially designed beaker cell in the 3.5–4.3 V (vs. Li/Li+) voltage range. The LMO thin films were prepared using a solution deposition technique and their structures and morphologies were characterized by X-ray diffraction (XRD), Raman spectroscopy and scanning electron microscopy (SEM). The stressmore » evolution in the early part of the first delithiation cycle (<4.05 V) was consistent with the XRD data. However, stress evolution during later stages of the first delithiation cycle (>4.05 V) was not consistent with the XRD results, and showed irreversible behavior, suggesting irreversible changes in the electrode. Beyond the first delithiation cycle, the stress evolution was reversible, with a steady buildup of compressive and tensile stress during lithium insertion and extraction, respectively. Measurements on LMO films of varying thicknesses suggest that the first cycle irreversibility in stress response arises primarily from the electrode bulk.« less

Chain friction system gives positive, reversible drive

NASA Technical Reports Server (NTRS)

Davidsen, J. S.

1964-01-01

By cementing a strip of an elastomer to the smooth metal rim of the pulley and neoprene covered idlers providing suitable tension to the chain around the pulley, a positive reversible drive is accomplished more quietly and with less vibration.

DC Motor control using motor-generator set with controlled generator field

DOEpatents

Belsterling, Charles A.; Stone, John

1982-01-01

A d.c. generator is connected in series opposed to the polarity of a d.c. power source supplying a d.c. drive motor. The generator is part of a motor-generator set, the motor of which is supplied from the power source connected to the motor. A generator field control means varies the field produced by at least one of the generator windings in order to change the effective voltage output. When the generator voltage is exactly equal to the d.c. voltage supply, no voltage is applied across the drive motor. As the field of the generator is reduced, the drive motor is supplied greater voltage until the full voltage of the d.c. power source is supplied when the generator has zero field applied. Additional voltage may be applied across the drive motor by reversing and increasing the reversed field on the generator. The drive motor may be reversed in direction from standstill by increasing the generator field so that a reverse voltage is applied across the d.c. motor.

The population dynamics of bacteria, phage and RM Systems

NASA Astrophysics Data System (ADS)

Guet, Calin; Levin, Bruce; Pleska, Maros

Viruses drive and mediate bacterial evolution as parasites and vectors of horizontal gene transfer, respectively. Temperate bacteriophages, defined by the ability to lysogenize a fraction of hosts and to transmit horizontally as well as vertically in the form of prophages, frequently carry genes that increase fitness or contribute to bacterial pathogenicity. Restriction-modification (RM) systems, which are widely diverse and ubiquitous among bacteria, can prevent infections leading to lysis, but their effect on lysogeny is not clear. We show that RM systems prevent lytic and lysogenic infections to the same extent and therefore represent a molecular barrier to prophage acquisition. Surprisingly, we find that this negative effect can be overcome and even reversed at the population level, as a consequence of dynamic interactions between viruses, hosts and RM systems. Thus the population dynamics of bacteria carrying RM systems impacts bacterial genome-wide evolution. .

MULTIPLE DIFFERENTIAL ROTARY MECHANICAL DRIVE

DOEpatents

Smits, R.G.

1964-01-28

This patent relates to a mechanism suitable for such applications as driving two spaced-apart spools which carry a roll film strip under conditions where the film movement must be rapidly started, stopped, and reversed while maintaining a constant tension on the film. The basic drive is provided by a variable speed, reversible rnotor coupled to both spools through a first differential mechanism and driving both spools in the same direction. A second motor, providing a constant torque, is connected to the two spools through a second differential mechanism and is coupled to impart torque to one spool in a first direction anid to the other spool in the reverse direction thus applying a constant tension to the film passing over the two spools irrespective of the speed or direction of rotation thereof. (AEC)

Quantum gates by periodic driving.

PubMed

Shi, Z C; Wang, W; Yi, X X

2016-02-25

Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions-it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work, we present a method to realize single qubit quantum gates by periodic driving. Compared to adiabatic evolution, the single qubit gates can be realized at a fixed time much shorter than that by adiabatic evolution. The driving fields can be sinusoidal or square-well field. With the sinusoidal driving field, we derive an expression for the total operation time in the high-frequency limit, and an exact analytical expression for the evolution operator without any approximations is given for the square well driving. This study suggests that the period driving could provide us with a new direction in regulations of the operation time in topological quantum computation.

Reverse Algols

NASA Technical Reports Server (NTRS)

Leung, K. C.

1989-01-01

Reverse Algols, binary systems with a semidetached configuration in which the more massive component is in contact with the critical equipotential surface, are examined. Observational evidence for reverse Algols is presented and the parameters of seven reverse Algols are listed. The evolution of Algols and reverse Algols is discussed. It is suggested that, because reverse Algols represent the premass-reversal semidetached phase of close binary evolution, the evolutionary time scale between regular and reverse Algols is the ratio of the number of confirmed systems of these two Algol types.

Mobility scooter driving ability in visually impaired individuals.

PubMed

Cordes, Christina; Heutink, Joost; Brookhuis, Karel A; Brouwer, Wiebo H; Melis-Dankers, Bart J M

2018-06-01

To investigate how well visually impaired individuals can learn to use mobility scooters and which parts of the driving task deserve special attention. A mobility scooter driving skill test was developed to compare driving skills (e.g. reverse driving, turning) between 48 visually impaired (very low visual acuity = 14, low visual acuity = 10, peripheral field defects = 11, multiple visual impairments = 13) and 37 normal-sighted controls without any prior experience with mobility scooters. Performance on this test was rated on a three-point scale. Furthermore, the number of extra repetitions on the different elements were noted. Results showed that visually impaired participants were able to gain sufficient driving skills to be able to use mobility scooters. Participants with visual field defects combined with low visual acuity showed most problems learning different skills and needed more training. Reverse driving and stopping seemed to be most difficult. The present findings suggest that visually impaired individuals are able to learn to drive mobility scooters. Mobility scooter allocators should be aware that these individuals might need more training on certain elements of the driving task. Implications for rehabilitation Visual impairments do not necessarily lead to an inability to acquire mobility scooter driving skills. Individuals with peripheral field defects (especially in combination with reduced visual acuity) need more driving ability training compared to normal-sighted people - especially to accomplish reversing. Individual assessment of visually impaired people is recommended, since participants in this study showed a wide variation in ability to learn driving a mobility scooter.

Is the addition of an assisted driving Hamiltonian always useful for adiabatic evolution?

NASA Astrophysics Data System (ADS)

Sun, Jie; Lu, Songfeng; Li, Li

2017-04-01

It has been known that when an assisted driving item is added to the main system Hamiltonian, the efficiency of the resultant adiabatic evolution can be significantly improved. In some special cases, it can be seen that only through adding an assisted driving Hamiltonian can the resulting adiabatic evolution be made not to fail. Thus the additional driving Hamiltonian plays an important role in adiabatic computing. In this paper, we show that if the driving Hamiltonian is chosen inappropriately, the adiabatic computation may still fail. More importantly, we find that the adiabatic computation can only succeed if the assisted driving Hamiltonian has a relatively fixed form. This may help us understand why in the related literature all of the driving Hamiltonians used share the same form.

A novel strategy for exploring the reassortment origins of newly emerging influenza virus.

PubMed

Tian, Deqiao; Wang, Yumin; Zheng, Tao

2011-01-01

In early 2009, new swine-origin influenza A (H1N1) virus emerged in Mexico and the United States. The emerging influenza virus had made global influenza pandemic for nearly one year. To every emerging pathogen, exploring the origin sources is vital for viral control and clearance. Influenza virus is different from other virus in that it has 8 segments, making the segment reassortment a main drive in virus evolution. In exploring reassortment evolution origins of a newly emerging influenza virus, integrated comparing of the origin sources of all the segments is necessary. If some segments have high homologous with one parental strain, lower homologous with another parental strain, while other segments are reverse, can we proposed that this emerging influenza virus may re-assort from the two parental strains. Here we try to explore the multilevel reassortment evolution origins of 2009 H1N1 influenza virus using this method. By further validating the fidelity of this strategy, this method might be useful in judging the reassortment origins of newly emerging influenza virus.

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.

PubMed

Martinez-Outschoorn, Ubaldo E; Balliet, Renee M; Rivadeneira, Dayana B; Chiavarina, Barbara; Pavlides, Stephanos; Wang, Chenguang; Whitaker-Menezes, Diana; Daumer, Kristin M; Lin, Zhao; Witkiewicz, Agnieszka K; Flomenberg, Neal; Howell, Anthony; Pestell, Richard G; Knudsen, Erik S; Sotgia, Federica; Lisanti, Michael P

2010-08-15

Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of poor prognosis in human breast cancer patients, and is associated with early tumor recurrence, lymph node metastasis and tamoxifen-resistance. We developed a novel co-culture system to understand the mechanism(s) by which a loss of stromal fibroblast Cav-1 induces a "lethal tumor micro-environment." Here, we propose a new paradigm to explain the powerful prognostic value of stromal Cav-1. In this model, cancer cells induce oxidative stress in cancer-associated fibroblasts, which then acts as a "metabolic" and "mutagenic" motor to drive tumor-stroma co-evolution, DNA damage and aneuploidy in cancer cells. More specifically, we show that an acute loss of Cav-1 expression leads to mitochondrial dysfunction, oxidative stress and aerobic glycolysis in cancer associated fibroblasts. Also, we propose that defective mitochondria are removed from cancer-associated fibroblasts by autophagy/mitophagy that is induced by oxidative stress. As a consequence, cancer associated fibroblasts provide nutrients (such as lactate) to stimulate mitochondrial biogenesis and oxidative metabolism in adjacent cancer cells (the "Reverse Warburg Effect"). We provide evidence that oxidative stress in cancer-associated fibroblasts is sufficient to induce genomic instability in adjacent cancer cells, via a bystander effect, potentially increasing their aggressive behavior. Finally, we directly demonstrate that nitric oxide (NO) over-production, secondary to Cav-1 loss, is the root cause for mitochondrial dysfunction in cancer associated fibroblasts. In support of this notion, treatment with anti-oxidants (such as N-acetyl-cysteine, metformin and quercetin) or NO inhibitors (L-NAME) was sufficient to reverse many of the cancer-associated fibroblast phenotypes that we describe. Thus, cancer cells use "oxidative stress" in adjacent fibroblasts (i) as an "engine" to fuel their own survival via the stromal production of nutrients and (ii) to drive their own mutagenic evolution towards a more aggressive phenotype, by promoting genomic instability. We also present evidence that the "field effect" in cancer biology could also be related to the stromal production of ROS and NO species. eNOS-expressing fibroblasts have the ability to downregulate Cav-1 and induce mitochondrial dysfunction in adjacent fibroblasts that do not express eNOS. As such, the effects of stromal oxidative stress can be laterally propagated, amplified and are effectively "contagious"--spread from cell-to-cell like a virus--creating an "oncogenic/mutagenic" field promoting widespread DNA damage.

Measurements and modeling of transport and impurity radial profiles in the EXTRAP T2R reversed field pinch

NASA Astrophysics Data System (ADS)

Kuldkepp, M.; Brunsell, P. R.; Cecconello, M.; Dux, R.; Menmuir, S.; Rachlew, E.

2006-09-01

Radial impurity profiles of oxygen in the rebuilt reversed field pinch EXTRAP T2R [P. R. Brunsell et al., Plasma Phys. Control. Fusion 43, 1457 (2001)] have been measured with a multichannel spectrometer. Absolute ion densities for oxygen peak between 1-4×1010cm-3 for a central electron density of 1×1013cm-3. Transport simulations with the one-dimensional transport code STRAHL with a diffusion coefficient of 20m2 s-1 yield density profiles similar to those measured. Direct measurement of the ion profile evolution during pulsed poloidal current drive suggests that the diffusion coefficient is reduced by a factor ˜2 in the core but remains unaffected toward the edge. Core transport is not significantly affected by the radial magnetic field growth seen at the edge in discharges without feedback control. This indicates that the mode core amplitude remains the same while the mode eigenfunction increases at the edge.

How are Inner Hair Cells Stimulated? Evidence for multiple mechanical drives

PubMed Central

Guinan, John J.

2013-01-01

Recent studies indicate that the gap over outer hair cells (OHCs) between the reticular lamina (RL) and the tectorial membrane (TM) varies cyclically during low-frequency sounds. Variation in the RL-TM gap produces radial fluid flow in the gap that can drive inner hair cell (IHC) stereocilia. Analysis of RL-TM gap changes reveals three IHC drives in addition to classic SHEAR. For upward basilar-membrane (BM) motion, IHC stereocilia are deflected in the excitatory direction by SHEAR and OHC-MOTILITY, but in the inhibitory direction by TM-PUSH and CILIA-SLANT. Upward BM motion causes OHC somatic contraction which tilts the RL, compresses the RL-TM gap over IHCs and expands the RL-TM gap over OHCs, thereby producing an outward (away from the IHCs) radial fluid flow which is the OHC-MOTILITY drive. For upward BM motion, the force that moves the TM upward also compresses the RL-TM gap over OHCs causing inward radial flow past IHCs which is the TM-PUSH drive. Motions that produce large tilting of OHC stereocilia squeeze the supra-OHC RL-TM gap and caused inward radial flow past IHCs which is the CILIA-SLANT drive. Combinations of these drives explain: (1) the reversal at high sound levels of auditory nerve (AN) initial peak (ANIP) responses to clicks, and medial olivocochlear (MOC) inhibition of ANIP responses below, but not above, the ANIP reversal, (2) dips and phase reversals in AN responses to tones in cats and chinchillas, (3) hypersensitivity and phase reversals in tuning-curve tails after OHC ablation, and (4) MOC inhibition of tail-frequency AN responses. The OHC-MOTILITY drive provides another mechanism, in addition to BM motion amplification, that uses active processes to enhance the output of the cochlea. The ability of these IHC drives to explain previously anomalous data provides strong, although indirect, evidence that these drives are significant and presents a new view of how the cochlea works at frequencies below 3 kHz. PMID:22959529

Sensitivity of geomagnetic reversal rate on core evolution from numerical dynamos

NASA Astrophysics Data System (ADS)

Driscoll, P. E.; Davies, C. J.

2017-12-01

The paleomagnetic record indicates the geodynamo has evolved from frequently reversing to non-reversing (superchron) magnetic states several times over the Phanerozoic. Previous theoretical studies demonstrated a positive correlation between magnetic reversal rate and core-mantle boundary heat flux. However, attempts to identify such a correlation between reversal rates and proxies for internal cooling rate, such as plume events, superchron cycles, and subduction rates, have been inconclusive. Here we revisit the magnetic reversal occurrence rate in numerical dynamos at low Ekman numbers (faster rotation) and high magnetic Prandtl numbers (ratio of viscous and magnetic diffusivities). We focus on how the correlation between reversal rate and convective power depends on the core evolution rate and on other factors, such as Ek, Pm, and thermal boundary conditions. We apply our results to the seafloor reversal record in an attempt to infer the energetic evolution of the lower mantle and core over that period.

Base drive circuit for a four-terminal power Darlington

DOEpatents

Lee, Fred C.; Carter, Roy A.

1983-01-01

A high power switching circuit which utilizes a four-terminal Darlington transistor block to improve switching speed, particularly in rapid turn-off. Two independent reverse drive currents are utilized during turn off in order to expel the minority carriers of the Darlington pair at their own charge sweep-out rate. The reverse drive current may be provided by a current transformer, the secondary of which is tapped to the base terminal of the power stage of the Darlington block. In one application, the switching circuit is used in each power switching element in a chopper-inverter drive of an electric vehicle propulsion system.

Fluctuating environments, sexual selection and the evolution of flexible mate choice in birds.

PubMed

Botero, Carlos A; Rubenstein, Dustin R

2012-01-01

Environmentally-induced fluctuation in the form and strength of natural selection can drive the evolution of morphology, physiology, and behavior. Here we test the idea that fluctuating climatic conditions may also influence the process of sexual selection by inducing unexpected reversals in the relative quality or sexual attractiveness of potential breeding partners. Although this phenomenon, known as 'ecological cross-over', has been documented in a variety of species, it remains unclear the extent to which it has driven the evolution of major interspecific differences in reproductive behavior. We show that after controlling for potentially influential life history and demographic variables, there are significant positive associations between the variability and predictability of annual climatic cycles and the prevalence of infidelity and divorce within populations of a taxonomically diverse array of socially monogamous birds. Our results are consistent with the hypothesis that environmental factors have shaped the evolution of reproductive flexibility and suggest that in the absence of severe time constraints, secondary mate choice behaviors can help prevent, correct, or minimize the negative consequences of ecological cross-overs. Our findings also illustrate how a basic evolutionary process like sexual selection is susceptible to the increasing variability and unpredictability of climatic conditions that is resulting from climate change.

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis.

PubMed

McDonald, Oliver G; Li, Xin; Saunders, Tyler; Tryggvadottir, Rakel; Mentch, Samantha J; Warmoes, Marc O; Word, Anna E; Carrer, Alessandro; Salz, Tal H; Natsume, Sonoko; Stauffer, Kimberly M; Makohon-Moore, Alvin; Zhong, Yi; Wu, Hao; Wellen, Kathryn E; Locasale, Jason W; Iacobuzio-Donahue, Christine A; Feinberg, Andrew P

2017-03-01

During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death. However, the genetics of metastases largely reflects that of the primary tumor in untreated patients, and PDAC driver mutations are shared by all subclones. This raises the possibility that an epigenetic process might operate during metastasis. Here we report large-scale reprogramming of chromatin modifications during the natural evolution of distant metastasis. Changes were targeted to thousands of large chromatin domains across the genome that collectively specified malignant traits, including euchromatin and large organized chromatin histone H3 lysine 9 (H3K9)-modified (LOCK) heterochromatin. Remarkably, distant metastases co-evolved a dependence on the oxidative branch of the pentose phosphate pathway (oxPPP), and oxPPP inhibition selectively reversed reprogrammed chromatin, malignant gene expression programs, and tumorigenesis. These findings suggest a model whereby linked metabolic-epigenetic programs are selected for enhanced tumorigenic fitness during the evolution of distant metastasis.

Holokinetic drive: centromere drive in chromosomes without centromeres.

PubMed

Bureš, Petr; Zedek, František

2014-08-01

Similar to how the model of centromere drive explains the size and complexity of centromeres in monocentrics (organisms with localized centromeres), our model of holokinetic drive is consistent with the divergent evolution of chromosomal size and number in holocentrics (organisms with nonlocalized centromeres) exhibiting holokinetic meiosis (holokinetics). Holokinetic drive is proposed to facilitate chromosomal fission and/or repetitive DNA removal (or any segmental deletion) when smaller homologous chromosomes are preferentially inherited or chromosomal fusion and/or repetitive DNA proliferation (or any segmental duplication) when larger homologs are preferred. The hypothesis of holokinetic drive is supported primarily by the negative correlation between chromosome number and genome size that is documented in holokinetic lineages. The supporting value of two older cross-experiments on holokinetic structural heterozygotes (the rush Luzula elegans and butterflies of the genus Antheraea) that indicate the presence of size-preferential homolog transmission via female meiosis for holokinetic drive is discussed, along with the further potential consequences of holokinetic drive in comparison with centromere drive. © 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.

Identifying cognitive distraction using steering wheel reversal rates.

PubMed

Kountouriotis, Georgios K; Spyridakos, Panagiotis; Carsten, Oliver M J; Merat, Natasha

2016-11-01

The influence of driver distraction on driving performance is not yet well understood, but it can have detrimental effects on road safety. In this study, we examined the effects of visual and non-visual distractions during driving, using a high-fidelity driving simulator. The visual task was presented either at an offset angle on an in-vehicle screen, or on the back of a moving lead vehicle. Similar to results from previous studies in this area, non-visual (cognitive) distraction resulted in improved lane keeping performance and increased gaze concentration towards the centre of the road, compared to baseline driving, and further examination of the steering control metrics indicated an increase in steering wheel reversal rates, steering wheel acceleration, and steering entropy. We show, for the first time, that when the visual task is presented centrally, drivers' lane deviation reduces (similar to non-visual distraction), whilst measures of steering control, overall, indicated more steering activity, compared to baseline. When using a visual task that required the diversion of gaze to an in-vehicle display, but without a manual element, lane keeping performance was similar to baseline driving. Steering wheel reversal rates were found to adequately tease apart the effects of non-visual distraction (increase of 0.5° reversals) and visual distraction with offset gaze direction (increase of 2.5° reversals). These findings are discussed in terms of steering control during different types of in-vehicle distraction, and the possible role of manual interference by distracting secondary tasks. Copyright © 2016 Elsevier Ltd. All rights reserved.

Quantum gates by periodic driving

PubMed Central

Shi, Z. C.; Wang, W.; Yi, X. X.

2016-01-01

Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions—it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work, we present a method to realize single qubit quantum gates by periodic driving. Compared to adiabatic evolution, the single qubit gates can be realized at a fixed time much shorter than that by adiabatic evolution. The driving fields can be sinusoidal or square-well field. With the sinusoidal driving field, we derive an expression for the total operation time in the high-frequency limit, and an exact analytical expression for the evolution operator without any approximations is given for the square well driving. This study suggests that the period driving could provide us with a new direction in regulations of the operation time in topological quantum computation. PMID:26911900

A pivot mutation impedes reverse evolution across an adaptive landscape for drug resistance in Plasmodium vivax.

PubMed

Ogbunugafor, C Brandon; Hartl, Daniel

2016-01-25

The study of reverse evolution from resistant to susceptible phenotypes can reveal constraints on biological evolution, a topic for which evolutionary theory has relatively few general principles. The public health catastrophe of antimicrobial resistance in malaria has brought these constraints on evolution into a practical realm, with one proposed solution: withdrawing anti-malarial medication use in high resistance settings, built on the assumption that reverse evolution occurs readily enough that populations of pathogens may revert to their susceptible states. While past studies have suggested limits to reverse evolution, there have been few attempts to properly dissect its mechanistic constraints. Growth rates were determined from empirical data on the growth and resistance from a set of combinatorially complete set of mutants of a resistance protein (dihydrofolate reductase) in Plasmodium vivax, to construct reverse evolution trajectories. The fitness effects of individual mutations were calculated as a function of drug environment, revealing the magnitude of epistatic interactions between mutations and genetic backgrounds. Evolution across the landscape was simulated in two settings: starting from the population fixed for the quadruple mutant, and from a polymorphic population evenly distributed between double mutants. A single mutation of large effect (S117N) serves as a pivot point for evolution to high resistance regions of the landscape. Through epistatic interactions with other mutations, this pivot creates an epistatic ratchet against reverse evolution towards the wild type ancestor, even in environments where the wild type is the most fit of all genotypes. This pivot mutation underlies the directional bias in evolution across the landscape, where evolution towards the ancestor is precluded across all examined drug concentrations from various starting points in the landscape. The presence of pivot mutations can dictate dynamics of evolution across adaptive landscape through epistatic interactions within a protein, leaving a population trapped on local fitness peaks in an adaptive landscape, unable to locate ancestral genotypes. This irreversibility suggests that the structure of an adaptive landscape for a resistance protein should be understood before considering resistance management strategies. This proposed mechanism for constraints on reverse evolution corroborates evidence from the field indicating that phenotypic reversal often occurs via compensatory mutation at sites independent of those associated with the forward evolution of resistance. Because of this, molecular methods that identify resistance patterns via single SNPs in resistance-associated markers might be missing signals for resistance and compensatory mutation throughout the genome. In these settings, whole genome sequencing efforts should be used to identify resistance patterns, and will likely reveal a more complicated genomic signature for resistance and susceptibility, especially in settings where anti-malarial medications have been used intermittently. Lastly, the findings suggest that, given their role in dictating the dynamics of evolution across the landscape, pivot mutations might serve as future targets for therapy.

The reversed and normal flux contributions to axial dipole decay for 1880-2015

NASA Astrophysics Data System (ADS)

Metman, M. C.; Livermore, P. W.; Mound, J. E.

2018-03-01

The axial dipole component of Earth's internal magnetic field has been weakening since at least 1840, an effect widely believed to be attributed to the evolution of reversed flux patches (RFPs). These are regions on the core-mantle boundary (CMB) where the sign of radial flux deviates from that of the dominant sign of hemispheric radial flux. We study dipole change over the past 135 years using the field models gufm1, COV-OBS.x1 and CHAOS-6; we examine the impact of the choice of magnetic equator on the identification of reversed flux, the contribution of reversed and normal flux to axial dipole decay, and how reversed and normal field evolution has influenced the axial dipole. We show that a magnetic equator defined as a null-flux curve of the magnetic field truncated at spherical harmonic degree 3 allows us to robustly identify reversed flux, which we demonstrate is a feature of at least degree 4 or 5. Additionally, our results indicate that the evolution of reversed flux accounts for approximately two-thirds of the decay of the axial dipole, while one third of the decay is attributed to the evolution of the normal field. We find that the decay of the axial dipole over the 20th century is associated with both the expansion and poleward migration of reversed flux patches. In contrast to this centennial evolution, changes in the structure of secular variation since epoch 2000 indicate that poleward migration currently plays a much reduced role in the ongoing dipole decay.

Two-step optimization of pressure and recovery of reverse osmosis desalination process.

PubMed

Liang, Shuang; Liu, Cui; Song, Lianfa

2009-05-01

Driving pressure and recovery are two primary design variables of a reverse osmosis process that largely determine the total cost of seawater and brackish water desalination. A two-step optimization procedure was developed in this paper to determine the values of driving pressure and recovery that minimize the total cost of RO desalination. It was demonstrated that the optimal net driving pressure is solely determined by the electricity price and the membrane price index, which is a lumped parameter to collectively reflect membrane price, resistance, and service time. On the other hand, the optimal recovery is determined by the electricity price, initial osmotic pressure, and costs for pretreatment of raw water and handling of retentate. Concise equations were derived for the optimal net driving pressure and recovery. The dependences of the optimal net driving pressure and recovery on the electricity price, membrane price, and costs for raw water pretreatment and retentate handling were discussed.

Early evolution of an energetic coronal mass ejection and its relation to EUV waves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Rui; Wang, Yuming; Shen, Chenglong, E-mail: rliu@ustc.edu.cn

2014-12-10

We study a coronal mass ejection (CME) associated with an X-class flare whose initiation is clearly observed in the low corona with high-cadence, high-resolution EUV images, providing us a rare opportunity to witness the early evolution of an energetic CME in detail. The eruption starts with a slow expansion of cool overlying loops (∼1 MK) following a jet-like event in the periphery of the active region. Underneath the expanding loop system, a reverse S-shaped dimming is seen immediately above the brightening active region in hot EUV passbands. The dimming is associated with a rising diffuse arch (∼6 MK), which wemore » interpret as a preexistent, high-lying flux rope. This is followed by the arising of a double hot channel (∼10 MK) from the core of the active region. The higher structures rise earlier and faster than lower ones, with the leading front undergoing extremely rapid acceleration up to 35 km s{sup –2}. This suggests that the torus instability is the major eruption mechanism and that it is the high-lying flux rope rather than the hot channels that drives the eruption. The compression of coronal plasmas skirting and overlying the expanding loop system, whose aspect ratio h/r increases with time as a result of the rapid upward acceleration, plays a significant role in driving an outward-propagating global EUV wave and a sunward-propagating local EUV wave, respectively.« less

Reconstructing the Cenozoic evolution of the mantle: Implications for mantle plume dynamics under the Pacific and Indian plates

NASA Astrophysics Data System (ADS)

Glišović, Petar; Forte, Alessandro M.

2014-03-01

The lack of knowledge of the initial thermal state of the mantle in the geological past is an outstanding problem in mantle convection. The resolution of this problem also requires the modelling of 3-D mantle evolution that yields maximum consistency with a wide suite of geophysical constraints. Quantifying the robustness of the reconstructed thermal evolution is another major concern. To solve and estimate the robustness of the time-reversed (inverse) problem of mantle convection, we analyse two different numerical techniques: the quasi-reversible (QRV) and the backward advection (BAD) methods. Our investigation extends over the 65 Myr interval encompassing the Cenozoic era using a pseudo-spectral solution for compressible-flow thermal convection in 3-D spherical geometry. We find that the two dominant issues for solving the inverse problem of mantle convection are the choice of horizontally-averaged temperature (i.e., geotherm) and mechanical surface boundary conditions. We find, in particular, that the inclusion of thermal boundary layers that yield Earth-like heat flux at the top and bottom of the mantle has a critical impact on the reconstruction of mantle evolution. We have developed a new regularisation scheme for the QRV method using a time-dependent regularisation function. This revised implementation of the QRV method delivers time-dependent reconstructions of mantle heterogeneity that reveal: (1) the stability of Pacific and African ‘large low shear velocity provinces’ (LLSVP) over the last 65 Myr; (2) strong upward deflections of the CMB topography at 65 Ma beneath: the North Atlantic, the south-central Pacific, the East Pacific Rise (EPR) and the eastern Antarctica; (3) an anchored deep-mantle plume ascending directly under the EPR (Easter and Pitcairn hotspots) throughout the Cenozoic era; and (4) the appearance of the transient Reunion plume head beneath the western edge of the Deccan Plateau at 65 Ma. Our reconstructions of Cenozoic mantle evolution thus suggest that mantle plumes play a key role in driving surface tectonic processes and large-scale volcanism.

Monitoring of aeolian desertification on the Qinghai-Tibet Plateau from the 1970s to 2015 using Landsat images.

PubMed

Zhang, Chun-Lai; Li, Qing; Shen, Ya-Ping; Zhou, Na; Wang, Xue-Song; Li, Jiao; Jia, Wen-Ru

2018-04-01

Aeolian desertification, one of the most serious environmental issues, has hampered socioeconomic development on the Qinghai-Tibet Plateau (QTP). However, research on aeolian desertification in this region has been limited. To develop a set of science-based preventive measures to mitigate desertification in this region, it is first necessary to clarify the status, evolution, and driving factors of aeolian desertification. In this study, based on extensive field investigations and a current classification system for aeolian desertification, we established a new system for interpreting aeolian desertified land (ADL) on the plateau using Landsat images from 1977, 1990, 2000, 2010, and 2015 and obtained the distribution of ADL through visual interpretation of the images. The results showed that ADL covered 392,914km 2 (15.1% of the study area) in 2015, including gravel ADL, sandy ADL, and aeolian monadnocks. Controlled by climate, landforms, the type of Quaternary deposit, and human activities, ADL is scattered throughout the plateau but is concentrated mostly in the western and northern parts. Aeolian desertification on the plateau expanded from 1977 to 2000 and then began to reverse. The evolution during the study period is the result of the combined effects of natural and human factors. Irrational human activities were the dominant factor responsible for the expansion of ADL prior to 2000, whereas the subsequent reversal was mainly caused by climate change combined with large ecological restoration projects. Copyright © 2017 Elsevier B.V. All rights reserved.

Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?

PubMed Central

Mosca, Alexis; Leclerc, Marion; Hugot, Jean P.

2016-01-01

Most of the Human diseases affecting westernized countries are associated with dysbiosis and loss of microbial diversity in the gut microbiota. The Western way of life, with a wide use of antibiotics and other environmental triggers, may reduce the number of bacterial predators leading to a decrease in microbial diversity of the Human gut. We argue that this phenomenon is similar to the process of ecosystem impoverishment in macro ecology where human activity decreases ecological niches, the size of predator populations, and finally the biodiversity. Such pauperization is fundamental since it reverses the evolution processes, drives life backward into diminished complexity, stability, and adaptability. A simple therapeutic approach could thus be to reintroduce bacterial predators and restore a bacterial diversity of the host microbiota. PMID:27065999

Floquet topological phases with symmetry in all dimensions

NASA Astrophysics Data System (ADS)

Roy, Rahul; Harper, Fenner

2017-05-01

Dynamical systems may host a number of remarkable symmetry-protected phases that are qualitatively different from their static analogs. In this work, we consider the phase space of symmetry-respecting unitary evolutions in detail and identify several distinct classes of evolution that host dynamical order. Using ideas from group cohomology, we construct a set of interacting Floquet drives that generate dynamical symmetry-protected topological order for each nontrivial cohomology class in every dimension, illustrating our construction with explicit two-dimensional examples. We also identify a set of symmetry-protected Floquet drives that lie outside of the group cohomology construction, and a further class of symmetry-respecting topological drives which host chiral edge modes. We use these special drives to define a notion of phase (stable to a class of local perturbations in the bulk) and the concepts of relative and absolute topological order, which can be applied to many different classes of unitary evolutions. These include fully many-body localized unitary evolutions and time crystals.

A history of reverse total shoulder arthroplasty.

PubMed

Flatow, Evan L; Harrison, Alicia K

2011-09-01

Management of the cuff-deficient arthritic shoulder has long been challenging. Early unconstrained shoulder arthroplasty systems were associated with high complication and implant failure rates. The evolution toward the modern reverse shoulder arthroplasty includes many variables of constrained shoulder arthroplasty designs. This review explores the development of reverse shoulder arthroplasty, specifically describing (1) the evolution of reverse shoulder arthroplasty designs, (2) the biomechanical variations in the evolution of this arthroplasty, and (3) the current issues relevant to reverse shoulder arthroplasty today. Using a PubMed search, the literature was explored for articles addressing reverse shoulder arthroplasty, focusing on those papers with historical context. Results of the early designs were apparently poor, although they were not subjected to rigorous clinical research and usually reported only in secondary literature. We identified a trend of glenoid component failure in the early reverse designs. This trend was recognized and reported by authors as the reverse shoulder evolved. Authors reported greater pain relief and better function in reverse shoulder arthroplasty with the fundamental change of Grammont's design (moving the center of rotation medially and distally). However, current reports suggest lingering concerns and challenges with today's designs. The history of reverse shoulder arthroplasty involves the designs of many forward-thinking surgeons. Many of these highly constrained systems failed, although more recent designs have demonstrated improved longevity and implant performance. Reverse shoulder arthroplasty requires ongoing study, with challenges and controversies remaining around present-day designs.

Company Profile: Selventa, Inc.

PubMed

Fryburg, David A; Latino, Louis J; Tagliamonte, John; Kenney, Renee D; Song, Diane H; Levine, Arnold J; de Graaf, David

2012-08-01

Selventa, Inc. (MA, USA) is a biomarker discovery company that enables personalized healthcare. Originally founded as Genstruct, Inc., Selventa has undergone significant evolution from a technology-based service provider to an active partner in the development of diagnostic tests, functioning as a molecular dashboard of disease activity using a unique platform. As part of that evolution, approximately 2 years ago the company was rebranded as Selventa to reflect its new identity and mission. The contributions to biomedical research by Selventa are based on in silico, reverse-engineering methods to determine biological causality. That is, given a set of in vitro or in vivo biological observations, which biological mechanisms can explain the measured results? Facilitated by a large and carefully curated knowledge base, these in silico methods generated new insights into the mechanisms driving a disease. As Selventa's methods would enable biomarker discovery and be directly applicable to generating novel diagnostics, the scientists at Selventa have focused on the development of predictive biomarkers of response in autoimmune and oncologic diseases. Selventa is presently building a portfolio of independent, as well as partnered, biomarker projects with the intention to create diagnostic tests that predict response to therapy.

Evolution: Help for the Confused.

ERIC Educational Resources Information Center

Scheer, Bradley T.

1979-01-01

Written in response to an earlier article questioning certain aspects of evolution theory. Discusses ontogeny and phylogeny, the basis of evolution, chance or purpose in evolution, micro and macro-evolution, reversibility, and the evolution processes today. (MA)

Sustained Photobiological Hydrogen Gas Production upon Reversible Inactivation of Oxygen Evolution in the Green Alga Chlamydomonas reinhardtii1

PubMed Central

Melis, Anastasios; Zhang, Liping; Forestier, Marc; Ghirardi, Maria L.; Seibert, Michael

2000-01-01

The work describes a novel approach for sustained photobiological production of H2 gas via the reversible hydrogenase pathway in the green alga Chlamydomonas reinhardtii. This single-organism, two-stage H2 production method circumvents the severe O2 sensitivity of the reversible hydrogenase by temporally separating photosynthetic O2 evolution and carbon accumulation (stage 1) from the consumption of cellular metabolites and concomitant H2 production (stage 2). A transition from stage 1 to stage 2 was effected upon S deprivation of the culture, which reversibly inactivated photosystem II (PSII) and O2 evolution. Under these conditions, oxidative respiration by the cells in the light depleted O2 and caused anaerobiosis in the culture, which was necessary and sufficient for the induction of the reversible hydrogenase. Subsequently, sustained cellular H2 gas production was observed in the light but not in the dark. The mechanism of H2 production entailed protein consumption and electron transport from endogenous substrate to the cytochrome b6-f and PSI complexes in the chloroplast thylakoids. Light absorption by PSI was required for H2 evolution, suggesting that photoreduction of ferredoxin is followed by electron donation to the reversible hydrogenase. The latter catalyzes the reduction of protons to molecular H2 in the chloroplast stroma. PMID:10631256

SINEs as driving forces in genome evolution.

PubMed

Schmitz, J

2012-01-01

SINEs are short interspersed elements derived from cellular RNAs that repetitively retropose via RNA intermediates and integrate more or less randomly back into the genome. SINEs propagate almost entirely vertically within their host cells and, once established in the germline, are passed on from generation to generation. As non-autonomous elements, their reverse transcription (from RNA to cDNA) and genomic integration depends on the activity of the enzymatic machinery of autonomous retrotransposons, such as long interspersed elements (LINEs). SINEs are widely distributed in eukaryotes, but are especially effectively propagated in mammalian species. For example, more than a million Alu-SINE copies populate the human genome (approximately 13% of genomic space), and few master copies of them are still active. In the organisms where they occur, SINEs are a challenge to genomic integrity, but in the long term also can serve as beneficial building blocks for evolution, contributing to phenotypic heterogeneity and modifying gene regulatory networks. They substantially expand the genomic space and introduce structural variation to the genome. SINEs have the potential to mutate genes, to alter gene expression, and to generate new parts of genes. A balanced distribution and controlled activity of such properties is crucial to maintaining the organism's dynamic and thriving evolution. Copyright © 2012 S. Karger AG, Basel.

Sex Ratio Bias Leads to the Evolution of Sex Role Reversal in Honey Locust Beetles.

PubMed

Fritzsche, Karoline; Booksmythe, Isobel; Arnqvist, Göran

2016-09-26

The reversal of conventional sex roles was enigmatic to Darwin, who suggested that it may evolve when sex ratios are female biased [1]. Here we present direct evidence confirming Darwin's hypothesis. We investigated mating system evolution in a sex-role-reversed beetle (Megabruchidius dorsalis) using experimental evolution under manipulated sex ratios and food regimes. In female-biased populations, where reproductive competition among females was intensified, females evolved to be more attractive and the sex roles became more reversed. Interestingly, female-specific mating behavior evolved more rapidly than male-specific mating behavior. We show that sexual selection due to reproductive competition can be strong in females and can target much the same traits as in males of species with conventional mating systems. Our study highlights two central points: the role of ecology in directing sexual selection and the role that females play in mating system evolution. Copyright © 2016 Elsevier Ltd. All rights reserved.

Sawtooth control in fusion plasmas

NASA Astrophysics Data System (ADS)

Graves, J. P.; Angioni, C.; Budny, R. V.; Buttery, R. J.; Coda, S.; Eriksson, L.-G.; Gimblett, C. G.; Goodman, T. P.; Hastie, R. J.; Henderson, M. A.; Koslowski, H. R.; Mantsinen, M. J.; Martynov, An; Mayoral, M.-L.; Mück, A.; Nave, M. F. F.; Sauter, O.; Westerhof, E.; Contributors, JET–EFDA

2005-12-01

Clear observations of early triggering of neo-classical tearing modes by sawteeth with long quiescent periods have motivated recent efforts to control, and in particular destabilize, sawteeth. One successful approach explored in TCV utilizes electron cyclotron heating in order to locally increase the current penetration time in the core. The latter is also achieved in various machines by depositing electron cyclotron current drive or ion cyclotron current drive close to the q = 1 rational surface. Crucially, localized current drive also succeeds in destabilizing sawteeth which are otherwise stabilized by a co-existing population of energetic trapped ions in the core. In addition, a recent reversed toroidal field campaign at JET demonstrates that counter-neutral beam injection (NBI) results in shorter sawtooth periods than in the Ohmic regime. The clear dependence of the sawtooth period on the NBI heating power and the direction of injection also manifests itself in terms of the toroidal plasma rotation, which consequently requires consideration in the theoretical interpretation of the experiments. Another feature of NBI, expected to be especially evident in the negative ion based neutral beam injection (NNBI) heating planned for ITER, is the parallel velocity asymmetry of the fast ion population. It is predicted that a finite orbit effect of asymmetrically distributed circulating ions could strongly modify sawtooth stability. Furthermore, NNBI driven current with non-monotonic profile could significantly slow down the evolution of the safety factor in the core, thereby delaying sawteeth.

Reynolds stress flow shear and turbulent energy transfer in reversed field pinch configuration

NASA Astrophysics Data System (ADS)

Vianello, Nicola; Spolaore, Monica; Serianni, Gianluigi; Regnoli, Giorgio; Spada, Emanuele; Antoni, Vanni; Bergsåker, Henric; Drake, James R.

2003-10-01

The role of Reynolds Stress tensor on flow generation in turbulent fluids and plasmas is still an open question and the comprehension of its behavior may assist the understanding of improved confinement scenario. It is generally believed that shear flow generation may occur by an interaction of the turbulent Reynolds stress with the shear flow. It is also generally believed that this mechanism may influence the generation of zonal flow shears. The evaluation of the complete Reynolds Stress tensor requires contemporary measurements of its electrostatic and magnetic part: this requirement is more restrictive for Reversed Field Pinch configuration where magnetic fluctuations are larger than in tokamak . A new diagnostic system which combines electrostatic and magnetic probes has been installed in the edge region of Extrap-T2R reversed field pinch. With this new probe the Reynolds stress tensor has been deduced and its radial profile has been reconstructed on a shot to shot basis exploring differen plasma conditions. These profiles have been compared with the naturally occurring velocity flow profile, in particular during Pulsed Poloidal Current Drive experiment, where a strong variation of ExB flow radial profile has been registered. The study of the temporal evolution of Reynolds stress reveals the appearance of strong localized bursts: these are considered in relation with global MHD relaxation phenomena, which naturally occur in the core of an RFP plasma sustaining its configuration.

Complex constraints on allometry revealed by artificial selection on the wing of Drosophila melanogaster

PubMed Central

Bolstad, Geir H.; Cassara, Jason A.; Márquez, Eladio; Hansen, Thomas F.; van der Linde, Kim; Houle, David; Pélabon, Christophe

2015-01-01

Precise exponential scaling with size is a fundamental aspect of phenotypic variation. These allometric power laws are often invariant across taxa and have long been hypothesized to reflect developmental constraints. Here we test this hypothesis by investigating the evolutionary potential of an allometric scaling relationship in drosophilid wing shape that is nearly invariant across 111 species separated by at least 50 million years of evolution. In only 26 generations of artificial selection in a population of Drosophila melanogaster, we were able to drive the allometric slope to the outer range of those found among the 111 sampled species. This response was rapidly lost when selection was suspended. Only a small proportion of this reversal could be explained by breakup of linkage disequilibrium, and direct selection on wing shape is also unlikely to explain the reversal, because the more divergent wing shapes produced by selection on the allometric intercept did not revert. We hypothesize that the reversal was instead caused by internal selection arising from pleiotropic links to unknown traits. Our results also suggest that the observed selection response in the allometric slope was due to a component expressed late in larval development and that variation in earlier development did not respond to selection. Together, these results are consistent with a role for pleiotropic constraints in explaining the remarkable evolutionary stability of allometric scaling. PMID:26371319

49 CFR 571.102 - Standard No. 102; Transmission shift position sequence, starter interlock, and transmission...

Code of Federal Regulations, 2012 CFR

2012-10-01

... hour). S2. Application. This standard applies to passenger cars, multi-purpose passenger vehicles... positions on passenger cars. A neutral position shall be located between forward drive and reverse drive... ratio, one forward drive position shall provide a greater degree of engine braking than the highest...

49 CFR 571.102 - Standard No. 102; Transmission shift position sequence, starter interlock, and transmission...

Code of Federal Regulations, 2011 CFR

2011-10-01

... hour). S2. Application. This standard applies to passenger cars, multi-purpose passenger vehicles... positions on passenger cars. A neutral position shall be located between forward drive and reverse drive... ratio, one forward drive position shall provide a greater degree of engine braking than the highest...

49 CFR 571.102 - Standard No. 102; Transmission shift position sequence, starter interlock, and transmission...

Code of Federal Regulations, 2014 CFR

2014-10-01

... hour). S2. Application. This standard applies to passenger cars, multi-purpose passenger vehicles... positions on passenger cars. A neutral position shall be located between forward drive and reverse drive... ratio, one forward drive position shall provide a greater degree of engine braking than the highest...

49 CFR 571.102 - Standard No. 102; Transmission shift position sequence, starter interlock, and transmission...

Code of Federal Regulations, 2013 CFR

2013-10-01

... hour). S2. Application. This standard applies to passenger cars, multi-purpose passenger vehicles... positions on passenger cars. A neutral position shall be located between forward drive and reverse drive... ratio, one forward drive position shall provide a greater degree of engine braking than the highest...

Influence of wheelchair front caster wheel on reverse directional stability.

PubMed

Guo, Songfeng; Cooper, Rory A; Corfman, Tom; Ding, Dan; Grindle, Garrett

2003-01-01

The purpose of this research was to study directional stability during reversing of rear-wheel drive, electric powered wheelchairs (EPW) under different initial front caster orientations. Specifically, the weight distribution differences caused by certain initial caster orientations were examined as a possible mechanism for causing directional instability that could lead to accidents. Directional stability was quantified by measuring the drive direction error of the EPW by a motion analysis system. The ground reaction forces were collected to determine the load on the front casters, as well as back-emf data to attain the speed of the motors. The drive direction error was found to be different for various initial caster orientations. Drive direction error was greatest when both casters were oriented 90 degrees to the left or right, and least when both casters were oriented forward. The results show that drive direction error corresponds to the loading difference on the casters. The data indicates that loading differences may cause asymmetric drag on the casters, which in turn causes unbalanced torque load on the motors. This leads to a difference in motor speed and drive direction error.

Evidence from a cohort of able bodied adults to support the need for driver training for motorized scooters before community participation.

PubMed

Nitz, Jennifer C

2008-02-01

This study sought to utilize the implementation of a new competency test in order to define skills required to safely drive a motorized scooter. This test endeavours to reduce the number of driving and pedestrian related accidents, by determining an acceptable level of driver skill and awareness. Healthy subjects, who might at some time use a motorized scooter for mobility, were recruited from the local community. Each undertook a driver competency test including basic driving skills, traffic and multiple tasks. Ten subjects repeated the test three times to determine practice effect on proficiency. Thirty-three of the 50 participating subjects (mean age 34 years) failed at least one test item. Basic skills of reversing, weave and zigzag, and all traffic and performing multiple simultaneous tasks produced failures. Driving skills for motorized scooters need to be taught and learned with assessment for competency recommended before unrestricted community driving is allowed. Basic driving skills including weaving, steering in reverse and traffic and multiple tasking need to be taught and tested for all new users of this equipment.

Concerning RNA-guided gene drives for the alteration of wild populations.

PubMed

Esvelt, Kevin M; Smidler, Andrea L; Catteruccia, Flaminia; Church, George M

2014-07-17

Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for RNA-guided gene drives based on the CRISPR nuclease Cas9 to serve as a general method for spreading altered traits through wild populations over many generations. We detail likely capabilities, discuss limitations, and provide novel precautionary strategies to control the spread of gene drives and reverse genomic changes. The ability to edit populations of sexual species would offer substantial benefits to humanity and the environment. For example, RNA-guided gene drives could potentially prevent the spread of disease, support agriculture by reversing pesticide and herbicide resistance in insects and weeds, and control damaging invasive species. However, the possibility of unwanted ecological effects and near-certainty of spread across political borders demand careful assessment of each potential application. We call for thoughtful, inclusive, and well-informed public discussions to explore the responsible use of this currently theoretical technology.

Monolithically integrated Si gate-controlled light-emitting device: science and properties

NASA Astrophysics Data System (ADS)

Xu, Kaikai

2018-02-01

The motivation of this study is to develop a p-n junction based light emitting device, in which the light emission is conventionally realized using reverse current driving, by voltage driving. By introducing an additional terminal of insulated gate for voltage driving, a novel three-terminal Si light emitting device is described where both the light intensity and spatial light pattern of the device are controlled by the gate voltage. The proposed light emitting device employs injection-enhanced Si in avalanche mode where electric field confinement occurs in the corner of a reverse-biased p+n junction. It is found that, depending on the bias conditions, the light intensity is either a linear or a quadratic function of the applied gate voltage or the reverse-bias. Since the light emission is based on the avalanching mode, the Si light emitting device offers the potential for very large scale integration-compatible light emitters for inter- or intra-chip signal transmission and contactless functional testing of wafers.

Relaxation of herbivore-mediated selection drives the evolution of genetic covariances between plant competitive and defense traits.

PubMed

Uesugi, Akane; Connallon, Tim; Kessler, André; Monro, Keyne

2017-06-01

Insect herbivores are important mediators of selection on traits that impact plant defense against herbivory and competitive ability. Although recent experiments demonstrate a central role for herbivory in driving rapid evolution of defense and competition-mediating traits, whether and how herbivory shapes heritable variation in these traits remains poorly understood. Here, we evaluate the structure and evolutionary stability of the G matrix for plant metabolites that are involved in defense and allelopathy in the tall goldenrod, Solidago altissima. We show that G has evolutionarily diverged between experimentally replicated populations that evolved in the presence versus the absence of ambient herbivory, providing direct evidence for the evolution of G by natural selection. Specifically, evolution in an herbivore-free habitat altered the orientation of G, revealing a negative genetic covariation between defense- and competition-related metabolites that is typically masked in herbivore-exposed populations. Our results may be explained by predictions of classical quantitative genetic theory, as well as the theory of acquisition-allocation trade-offs. The study provides compelling evidence that herbivory drives the evolution of plant genetic architecture. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

Sex drives intracellular conflict in yeast.

PubMed

Harrison, E; MacLean, R C; Koufopanou, V; Burt, A

2014-08-01

Theory predicts that sex can drive the evolution of conflict within the cell. During asexual reproduction, genetic material within the cell is inherited as a single unit, selecting for cooperation both within the genome as well as between the extra-genomic elements within the cell (e.g. plasmids and endosymbionts). Under sexual reproduction, this unity is broken down as parental genomes are distributed between meiotic progeny. Genetic elements able to transmit to more than 50% of meiotic progeny have a transmission advantage over the rest of the genome and are able to spread, even where they reduce the fitness of the individual as a whole. Sexual reproduction is therefore expected to drive the evolution of selfish genetic elements (SGEs). Here, we directly test this hypothesis by studying the evolution of two independent SGEs, the 2-μm plasmid and selfish mitochondria, in populations of Saccharomyces cerevisiae. Following 22 rounds of sexual reproduction, 2-μm copy number increased by approximately 13.2 (±5.6) copies per cell, whereas in asexual populations copy number decreased by approximately 5.1 (±1.5) copies per cell. Given that the burden imposed by this parasite increases with copy number, these results support the idea that sex drives the evolution of increased SGE virulence. Moreover, we found that mitochondria that are respiratory-deficient rapidly invaded sexual but not asexual populations, demonstrating that frequent outcrossed sex can drive the de novo evolution of genetic parasites. Our study highlights the genomic perils of sex and suggests that SGEs may play a key role in driving major evolutionary transitions, such as uniparental inheritance. © 2014 The Authors. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.

Towards understanding what contributes to forming an opinion

NASA Astrophysics Data System (ADS)

Wang, Peng; Song, Jia; Huo, Jie; Hao, Rui; Wang, Xu-Ming

Opinion evolution mechanism can be captured by physical modeling. In this paper, a kinetic equation is established by defining a generalized displacement(cognitive level), a driving force and the related factors such as generalized potential, information quantity and attitude. It has been shown that the details of opinion evolution depend on the type of the driving force, self-dominated driving or environment-dominated driving. In the former case, the participants can have their attitudes changed in the process of competition between the self-driving force and environment-driving force. In the latter case, all of the participants are pulled by the environment. Some regularities behind the dynamics of opinion are also revealed, for instance, the information entropy decays with time in a special way, etc. The results may help us to get some deep understanding for the formation of a public opinion.

Dynamically correlated mutations drive human Influenza A evolution.

PubMed

Tria, F; Pompei, S; Loreto, V

2013-01-01

Human Influenza A virus undergoes recurrent changes in the hemagglutinin (HA) surface protein, primarily involved in the human antibody recognition. Relevant antigenic changes, enabling the virus to evade host immune response, have been recognized to occur in parallel to multiple mutations at antigenic sites in HA. Yet, the role of correlated mutations (epistasis) in driving the molecular evolution of the virus still represents a challenging puzzle. Further, though circulation at a global geographic level is key for the survival of Influenza A, its role in shaping the viral phylodynamics remains largely unexplored. Here we show, through a sequence based epidemiological model, that epistatic effects between amino acids substitutions, coupled with a reservoir that mimics worldwide circulating viruses, are key determinants that drive human Influenza A evolution. Our approach explains all the up-to-date observations characterizing the evolution of H3N2 subtype, including phylogenetic properties, nucleotide fixation patterns, and composition of antigenic clusters.

Putative Independent Evolutionary Reversals from Genotypic to Temperature-Dependent Sex Determination are Associated with Accelerated Evolution of Sex-Determining Genes in Turtles.

PubMed

Literman, Robert; Burrett, Alexandria; Bista, Basanta; Valenzuela, Nicole

2018-01-01

The evolutionary lability of sex-determining mechanisms across the tree of life is well recognized, yet the extent of molecular changes that accompany these repeated transitions remain obscure. Most turtles retain the ancestral temperature-dependent sex determination (TSD) from which multiple transitions to genotypic sex determination (GSD) occurred independently, and two contrasting hypotheses posit the existence or absence of reversals back to TSD. Here we examined the molecular evolution of the coding regions of a set of gene regulators involved in gonadal development in turtles and several other vertebrates. We found slower molecular evolution in turtles and crocodilians compared to other vertebrates, but an acceleration in Trionychia turtles and at some phylogenetic branches demarcating major taxonomic diversification events. Of all gene classes examined, hormone signaling genes, and Srd5a1 in particular, evolve faster in many lineages and especially in turtles. Our data show that sex-linked genes do not follow a ubiquitous nor uniform pattern of molecular evolution. We then evaluated turtle nucleotide and protein evolution under two evolutionary hypotheses with or without GSD-to-TSD reversals, and found that when GSD-to-TSD reversals are considered, all transitional branches irrespective of direction, exhibit accelerated molecular evolution of nucleotide sequences, while GSD-to-TSD transitional branches also show acceleration in protein evolution. Significant changes in predicted secondary structure that may affect protein function were identified in three genes that exhibited hastened evolution in turtles compared to other vertebrates or in transitional versus non-transitional branches within turtles, rendering them candidates for a key role during SDM evolution in turtles.

Reverse matrix converter control method for PMSM drives using DPC

NASA Astrophysics Data System (ADS)

Bak, Yeongsu; Lee, Kyo-Beum

2018-05-01

This paper proposes a control method for a reverse matrix converter (RMC) that drives a three-phase permanent magnet synchronous motor (PMSM). In this proposed method, direct power control (DPC) is used to control the voltage source rectifier of the RMC. The RMC is an indirect matrix converter operating in the boost mode, in which the power-flow directions of the input and output are switched. It has a minimum voltage transfer ratio of 1/0.866 in a linear-modulation region. In this paper, a control method that uses DPC as an additional control method is proposed in order to control the RMC driving a PMSM in the output stage. Simulations and experimental results verify the effectiveness of the proposed control method.

Pliocene reversal of late Neogene aridification

PubMed Central

Sniderman, J. M. Kale; Woodhead, Jon D.; Jordan, Gregory J.; Drysdale, Russell N.; Tyler, Jonathan J.; Porch, Nicholas

2016-01-01

The Pliocene epoch (5.3–2.6 Ma) represents the most recent geological interval in which global temperatures were several degrees warmer than today and is therefore considered our best analog for a future anthropogenic greenhouse world. However, our understanding of Pliocene climates is limited by poor age control on existing terrestrial climate archives, especially in the Southern Hemisphere, and by persistent disagreement between paleo-data and models concerning the magnitude of regional warming and/or wetting that occurred in response to increased greenhouse forcing. To address these problems, here we document the evolution of Southern Hemisphere hydroclimate from the latest Miocene to the middle Pliocene using radiometrically-dated fossil pollen records preserved in speleothems from semiarid southern Australia. These data reveal an abrupt onset of warm and wet climates early within the Pliocene, driving complete biome turnover. Pliocene warmth thus clearly represents a discrete interval which reversed a long-term trend of late Neogene cooling and aridification, rather than being simply the most recent period of greater-than-modern warmth within a continuously cooling trajectory. These findings demonstrate the importance of high-resolution chronologies to accompany paleoclimate data and also highlight the question of what initiated the sustained interval of Pliocene warmth. PMID:26858429

A new back-and-forth iterative method for time-reversed convection modeling: Implications for the Cenozoic evolution of 3-D structure and dynamics of the mantle

NASA Astrophysics Data System (ADS)

Glišović, Petar; Forte, Alessandro M.

2016-06-01

The 3-D distribution of buoyancy in the convecting mantle drives a suite of convection-related manifestations. Although seismic tomography is providing increasingly resolved images of the present-day mantle heterogeneity, the distribution of mantle density variations in the geological past is unknown, and, by implication, this is true for the convection-related observables. The one major exception is tectonic plate motions, since geologic data are available to estimate their history and they currently provide the only available constraints on the evolution of 3-D mantle buoyancy in the past. We developed a new back-and-forth iterative method for time-reversed convection modeling with a procedure for matching plate velocity data at different instants in the past. The crucial aspect of this reconstruction methodology is to ensure that at all times plates are driven by buoyancy forces in the mantle and not vice versa. Employing tomography-based retrodictions over the Cenozoic, we estimate the global amplitude of the following observables: dynamic surface topography, the core-mantle boundary ellipticity, the free-air gravity anomalies, and the global divergence rates of tectonic plates. One of the major benefits of the new data assimilation method is the stable recovery of much shorter wavelength changes in heterogeneity than was possible in our previous work. We now resolve what appears to be two-stage subduction of the Farallon plate under the western U.S. and a deeply rooted East African Plume that is active under the Ethiopian volcanic fields during the Early Eocene.

Reversible adapting layer produces robust single-crystal electrocatalyst for oxygen evolution.

PubMed

Tung, Ching-Wei; Hsu, Ying-Ya; Shen, Yen-Ping; Zheng, Yixin; Chan, Ting-Shan; Sheu, Hwo-Shuenn; Cheng, Yuan-Chung; Chen, Hao Ming

2015-08-28

Electrochemically converting water into oxygen/hydrogen gas is ideal for high-density renewable energy storage in which robust electrocatalysts for efficient oxygen evolution play crucial roles. To date, however, electrocatalysts with long-term stability have remained elusive. Here we report that single-crystal Co3O4 nanocube underlay with a thin CoO layer results in a high-performance and high-stability electrocatalyst in oxygen evolution reaction. An in situ X-ray diffraction method is developed to observe a strong correlation between the initialization of the oxygen evolution and the formation of active metal oxyhydroxide phase. The lattice of skin layer adapts to the structure of the active phase, which enables a reversible facile structural change that facilitates the chemical reactions without breaking the scaffold of the electrocatalysts. The single-crystal nanocube electrode exhibits stable, continuous oxygen evolution for >1,000 h. This robust stability is attributed to the complementary nature of defect-free single-crystal electrocatalyst and the reversible adapting layer.

Reverse Evolution of Armor Plates in the Threespine Stickleback

USGS Publications Warehouse

Kitano, J.; Bolnick, D.I.; Beauchamp, D.A.; Mazur, M.M.; Mori, S.; Nakano, T.; Peichel, C.L.

2008-01-01

Faced with sudden environmental changes, animals must either adapt to novel environments or go extinct. Thus, study of the mechanisms underlying rapid adaptation is crucial not??only for the understanding of natural evolutionary processes but also for the understanding of human-induced evolutionary change, which is an increasingly important problem [1-8]. In the present study, we demonstrate that the frequency of completely plated threespine stickleback fish (Gasterosteus aculeatus) has increased in an urban freshwater lake (Lake Washington, Seattle, Washington) within the last 40 years. This is a dramatic example of "reverse evolution," [9] because the general evolutionary trajectory is toward armor-plate reduction in freshwater sticklebacks [10]. On the basis of our genetic studies and simulations, we propose that the most likely cause of reverse evolution is increased selection for the completely plated morph, which we suggest could result from higher levels of trout predation after a sudden increase in water transparency during the early 1970s. Rapid evolution was facilitated by the existence of standing allelic variation in Ectodysplasin (Eda), the gene that underlies the major plate-morph locus [11]. The Lake Washington stickleback thus provides a novel example of reverse evolution, which is probably caused by a change in allele frequency at the major plate locus in response to a changing predation regime. ?? 2008 Elsevier Ltd. All rights reserved.

Continuously-Variable Positive-Mesh Power Transmission

NASA Technical Reports Server (NTRS)

Johnson, J. L.

1982-01-01

Proposed transmission with continuously-variable speed ratio couples two mechanical trigonometric-function generators. Transmission is expected to handle higher loads than conventional variable-pulley drives; and, unlike variable pulley, positive traction through entire drive train with no reliance on friction to transmit power. Able to vary speed continuously through zero and into reverse. Possible applications in instrumentation where drive-train slippage cannot be tolerated.

The oxidative environment: a mediator of interspecies communication that drives symbiosis evolution.

PubMed

Moné, Yves; Monnin, David; Kremer, Natacha

2014-06-22

Symbiotic interactions are ubiquitous in nature and play a major role in driving the evolution of life. Interactions between partners are often mediated by shared signalling pathways, which strongly influence both partners' biology and the evolution of the association in various environments. As an example of 'common language', the regulation of the oxidative environment plays an important role in driving the evolution of symbiotic associations. Such processes have been occurring for billions of years, including the increase in Earth's atmospheric oxygen and the subsequent evolution of mitochondria. The effect of reactive oxygen species and reactive nitrogen species (RONS) has been characterized functionally, but the molecular dialogue between partners has not been integrated within a broader evolutionary context yet. Given the pleiotropic role of RONS in cell-cell communication, development and immunity, but also their associated physiological costs, we discuss here how their regulation can influence the establishment, the maintenance and the breakdown of various symbiotic associations. By synthesizing recent developments in redox biology, we aim to provide an interdisciplinary understanding of the influence of such mediators of interspecies communication on the evolution and stability of symbioses, which in turn can shape ecosystems and play a role in health and disease.

Reversible ratchet effects for vortices in conformal pinning arrays

DOE PAGES

Reichhardt, Charles; Ray, Dipanjan; Reichhardt, Cynthia Jane Olson

2015-05-04

A conformal transformation of a uniform triangular pinning array produces a structure called a conformal crystal which preserves the sixfold ordering of the original lattice but contains a gradient in the pinning density. Here we use numerical simulations to show that vortices in type-II superconductors driven with an ac drive over gradient pinning arrays produce the most pronounced ratchet effect over a wide range of parameters for a conformal array, while square gradient or random gradient arrays with equivalent pinning densities give reduced ratchet effects. In the conformal array, the larger spacing of the pinning sites in the direction transversemore » to the ac drive permits easy funneling of interstitial vortices for one driving direction, producing the enhanced ratchet effect. In the square array, the transverse spacing between pinning sites is uniform, giving no asymmetry in the funneling of the vortices as the driving direction switches, while in the random array, there are numerous easy-flow channels present for either direction of drive. We find multiple ratchet reversals in the conformal arrays as a function of vortex density and ac amplitude, and correlate the features with a reversal in the vortex ordering, which is greater for motion in the ratchet direction. In conclusion, the enhanced conformal pinning ratchet effect can also be realized for colloidal particles moving over a conformal array, indicating the general usefulness of conformal structures for controlling the motion of particles.« less

Concerning RNA-guided gene drives for the alteration of wild populations

PubMed Central

Esvelt, Kevin M; Smidler, Andrea L; Catteruccia, Flaminia; Church, George M

2014-01-01

Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for RNA-guided gene drives based on the CRISPR nuclease Cas9 to serve as a general method for spreading altered traits through wild populations over many generations. We detail likely capabilities, discuss limitations, and provide novel precautionary strategies to control the spread of gene drives and reverse genomic changes. The ability to edit populations of sexual species would offer substantial benefits to humanity and the environment. For example, RNA-guided gene drives could potentially prevent the spread of disease, support agriculture by reversing pesticide and herbicide resistance in insects and weeds, and control damaging invasive species. However, the possibility of unwanted ecological effects and near-certainty of spread across political borders demand careful assessment of each potential application. We call for thoughtful, inclusive, and well-informed public discussions to explore the responsible use of this currently theoretical technology. DOI: http://dx.doi.org/10.7554/eLife.03401.001 PMID:25035423

Deducing noninductive current profile from surface voltage evolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litwin, C.; Wukitch, S.; Hershkowitz, N.

Solving the resistive diffusion equation in the presence of a noninductive current source determines the time-evolution of the surface voltage. By inverting the problem the current drive profile can be determined from the surface voltage evolution. We show that under wide range of conditions the deduced profile is unique. If the conductivity profile is known, this method can be employed to infer the noninductive current profile, and, ipso facto, the profile of the total current. We discuss the application of this method to analyze the Alfven wave current drive experiments in Phaedrus-T.

Pollinator-mediated selection on floral display and flowering time in the perennial herb Arabidopsis lyrata.

PubMed

Sandring, Saskia; Agren, Jon

2009-05-01

The evolution of floral display and flowering time in animal-pollinated plants is commonly attributed to pollinator-mediated selection. Yet, the causes of selection on flowering phenology and traits contributing to floral display have rarely been tested experimentally in natural populations. We quantified phenotypic selection on morphological and phenological characters in the perennial, outcrossing herb Arabidopsis lyrata in two years using female reproductive success as a proxy of fitness. To determine whether selection on floral display and flowering phenology can be attributed to interactions with pollinators, selection was quantified both for open-pollinated controls and for plants receiving supplemental hand-pollination. We documented directional selection for many flowers, large petals, late start of flowering, and early end of flowering. Seed output was pollen-limited in both years and supplemental hand-pollination reduced the magnitude of selection on number of flowers, and reversed the direction of selection on end of flowering. The results demonstrate that interactions with pollinators may affect the strength of selection on floral display and the direction of selection on phenology of flowering in natural plant populations. They thus support the contention that pollinators can drive the evolution of both floral display and flowering time.

Turbulence, flow and transport: hints from reversed field pinch

NASA Astrophysics Data System (ADS)

Vianello, N.; Antoni, V.; Spada, E.; Spolaore, M.; Serianni, G.; Cavazzana, R.; Bergsåker, H.; Cecconello, M.; Drake, J. R.

2006-04-01

The interplay between sheared E × B flows and turbulence has been experimentally investigated in the edge region of the Extrap-T2R reversed field pinch experiment. Electrostatic fluctuations are found to rule the momentum balance equation representing the main driving term for sheared flows which counterbalances anomalous viscous damping. The driving role of electrostatic fluctuations is proved by the spatial structure of the Reynolds stress and by the time behaviour of the mean energy production term which supports the existence of an energy exchange from the small scales of turbulence to the larger scales of the mean flow.

Design and analysis of a new high frequency double-servo direct drive rotary valve

NASA Astrophysics Data System (ADS)

Zhu, Muzhi; Zhao, Shengdun; Li, Jingxiang

2016-12-01

Researchers have investigated direct drive valve for many years to solve problems, such as fluid force imbalance and switching frequency. The structure of the rotary valve has received considerable research interest because of its favorable dynamic properties and simple structure. This paper studied the high frequency doubleservo direct drive rotary valve (DDRV), and proposed a novel structure and drive method satisfying high reversing frequency and adequate quantity of flow. Servo motors are integrated into the valve by the innovative structure, which is designed to equilibrate the unbalanced radial fluid force with the symmetric distributed oil ports. Aside from the fast reversing function of the valve, the DDRV presented high performance in linearity of the flow quantity and valve opening as a result of the fan-shaped flow ports. In addition, a computational fluid dynamics (CFD) method based on Fluent was conducted to verify the flux regulation effect of the height change of the adjustable boss.

Dynamical Evolution of an Effective Two-Level System with {\\mathscr{P}}{\\mathscr{T}} Symmetry

NASA Astrophysics Data System (ADS)

Du, Lei; Xu, Zhihao; Yin, Chuanhao; Guo, Liping

2018-05-01

We investigate the dynamics of parity- and time-reversal (PT ) symmetric two-energy-level atoms in the presence of two optical and a radio-frequency (rf) fields. The strength and relative phase of fields can drive the system from unbroken to broken PT symmetric regions. Compared with the Hermitian model, Rabi-type oscillation is still observed, and the oscillation characteristics are also adjusted by the strength and relative phase in the region of unbroken PT symmetry. At exception point (EP), the oscillation breaks down. To better understand the underlying properties we study the effective Bloch dynamics and find the emergence of the z components of the fixed points is the feature of the PT symmetry breaking and the projections in x-y plane can be controlled with high flexibility compared with the standard two-level system with PT symmetry. It helps to study the dynamic behavior of the complex PT symmetric model.

Effects of convincing power and neutrality on minority opinion spreading

NASA Astrophysics Data System (ADS)

Wu, Yue; Xiong, Xi; Zhang, Yi

2017-02-01

The dynamics evolution of the minority opinion in public debates is studied using a convincing power (CP) model with neutrality. In a given group, an agent with a definite standpoint (yes or no) can be persuaded to be a neutral agent, if its capacity of persuasion is lower than the average CP of its opponents. Besides that a neutral agent will change its state and follow a more persuasive opinion. Starting from two opposite opinions with different rates, repeated local discussions are found to drive the minority reversal. It reveals that in addition to the initial minority, the number of neutral agents is also an important factor to the eventual winners. During the process of consensus, there exists a threshold of initial fraction to guarantee one side win. The results have a guiding significance for designing strategies to win a public debate.

The Southern Piedmont’s continued land-use evolution, 1973–2011

USGS Publications Warehouse

Auch, Roger F.; Napton, Darrell E.; Sayler, Kristi L.; Drummond, Mark A.; Kambly, Steven; Sorenson, Daniel G.

2015-01-01

The southern Piedmont in the U.S. was an important farming region during the 19th century, but by the end of the 20th century, agricultural land use had decreased substantially with forest becoming the majority land cover by the 1970s. Geographical literature has documented this change but has not concentrated on the region’s contemporary land uses. The Piedmont currently has three main types of land use and land cover changes: cyclic forestry, changes between forest and agriculture, and urbanization. The first and second groupings are reversible and land uses and land covers can change among them, but urbanization is normally a permanent change that increases in area through time. U.S. Geological Survey findings indicate that cyclic forestry of cutting (clearing) and regrowth dominated recent land change in the Piedmont. This paper explores the Piedmont’s current land uses and some of their driving forces.

Consumer co-evolution as an important component of the eco-evolutionary feedback.

PubMed

Hiltunen, Teppo; Becks, Lutz

2014-10-22

Rapid evolution in ecologically relevant traits has recently been recognized to significantly alter the interaction between consumers and their resources, a key interaction in all ecological communities. While these eco-evolutionary dynamics have been shown to occur when prey populations are evolving, little is known about the role of predator evolution and co-evolution between predator and prey in this context. Here, we investigate the role of consumer co-evolution for eco-evolutionary feedback in bacteria-ciliate microcosm experiments by manipulating the initial trait variation in the predator populations. With co-evolved predators, prey evolve anti-predatory defences faster, trait values are more variable, and predator and prey population sizes are larger at the end of the experiment compared with the non-co-evolved predators. Most importantly, differences in predator traits results in a shift from evolution driving ecology, to ecology driving evolution. Thus we demonstrate that predator co-evolution has important effects on eco-evolutionary dynamics.

Sperm competition generates evolution of increased paternal investment in a sex role-reversed seed beetle.

PubMed

Booksmythe, I; Fritzsche, K; Arnqvist, G

2014-12-01

When males provide females with resources at mating, they can become the limiting sex in reproduction, in extreme cases leading to the reversal of typical courtship roles. The evolution of male provisioning is thought to be driven by male reproductive competition and selection for female fecundity enhancement. We used experimental evolution under male- or female-biased sex ratios and limited or unlimited food regimes to investigate the relative roles of these routes to male provisioning in a sex role-reversed beetle, Megabruchidius tonkineus, where males provide females with nutritious ejaculates. Males evolving under male-biased sex ratios transferred larger ejaculates than did males from female-biased populations, demonstrating a sizeable role for reproductive competition in the evolution of male provisioning. Although larger ejaculates elevated female lifetime offspring production, we found little evidence of selection for larger ejaculates via fecundity enhancement: males evolving under resource-limited and unlimited conditions did not differ in mean ejaculate size. Resource limitation did, however, affect the evolution of conditional ejaculate allocation. Our results suggest that the resource provisioning that underpins sex role reversal in this system is the result of male-male reproductive competition rather than of direct selection for males to enhance female fecundity. © 2014 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.

Constraining the reversing and non-reversing modes of the geodynamo. New insights from magnetostratigraphy.

NASA Astrophysics Data System (ADS)

Gallet, Y.; Pavlov, V.; Shatsillo, A.; Hulot, G.

2015-12-01

Constraining the evolution in the geomagnetic reversal frequency over hundreds of million years is not a trivial matter. Beyond the fact that there are long periods without reversals, known as superchrons, and periods with many reversals, the way the reversal frequency changes through time during reversing periods is still debated. A smooth evolution or a succession of stationary segments have both been suggested to account for the geomagnetic polarity time scale since the Middle-Late Jurassic. Sudden changes from a reversing mode to a non-reversing mode of the geodynamo may also well have happened, the switch between the two modes having then possibly been controlled by the thermal conditions at the core-mantle boundary. There is, nevertheless, a growing set of magnetostratigraphic data, which could help decipher a proper interpretation of the reversal history, in particular in the early Paleozoic and even during the Precambrian. Although yielding a fragmentary record, these data reveal the occurrence of both additional superchrons and periods characterized by extremely high, not to say extraordinary, magnetic reversal frequencies. In this talk, we will present a synthesis of these data, mainly obtained from Siberia, and discuss their implication for the magnetic reversal behavior over the past billion years.

Smaller beaks for colder winters: Thermoregulation drives beak size evolution in Australasian songbirds.

PubMed

Friedman, Nicholas R; Harmáčková, Lenka; Economo, Evan P; Remeš, Vladimír

2017-08-01

Birds' beaks play a key role in foraging, and most research on their size and shape has focused on this function. Recent findings suggest that beaks may also be important for thermoregulation, and this may drive morphological evolution as predicted by Allen's rule. However, the role of thermoregulation in the evolution of beak size across species remains largely unexplored. In particular, it remains unclear whether the need for retaining heat in the winter or dissipating heat in the summer plays the greater role in selection for beak size. Comparative studies are needed to evaluate the relative importance of these functions in beak size evolution. We addressed this question in a clade of birds exhibiting wide variation in their climatic niche: the Australasian honeyeaters and allies (Meliphagoidea). Across 158 species, we compared species' climatic conditions extracted from their ranges to beak size measurements in a combined spatial-phylogenetic framework. We found that winter minimum temperature was positively correlated with beak size, while summer maximum temperature was not. This suggests that while diet and foraging behavior may drive evolutionary changes in beak shape, changes in beak size can also be explained by the beak's role in thermoregulation, and winter heat retention in particular. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

Arctic Ice-Ocean Coupling and Gyre Equilibration Observed With Remote Sensing

NASA Astrophysics Data System (ADS)

Dewey, Sarah; Morison, James; Kwok, Ronald; Dickinson, Suzanne; Morison, David; Andersen, Roger

2018-02-01

Model and observational evidence has shown that ocean current speeds in the Beaufort Gyre have increased and recently stabilized. Because these currents rival ice drift speeds, we examine the potential for the Beaufort Gyre's shift from a system in which the wind drives the ice and the ice drives a passive ocean to one in which the ocean often, in the absence of high winds, drives the ice. The resultant stress exerted on the ocean by the ice and the resultant Ekman pumping are reversed, without any change in average wind stress curl. Through these curl reversals, the ice-ocean stress provides a key feedback in Beaufort Gyre stabilization. This manuscript constitutes one of the first observational studies of ice-ocean stress inclusive of geostrophic ocean currents, by making use of recently available remote sensing data.

How to Drive CARS in Reverse

DTIC Science & Technology

2013-11-07

pulse . This pulse is then used to drive a coherent anti-Stokes Raman scattering scheme, resulting in a strong chemically specific signal propagating...generation of a backward propagating stimulated Raman pulse . This pulse is then used to drive a coherent anti-Stokes Raman scattering scheme, resulting in a...proposed to re- motely generate a spatially coherent backward propagating pulse . The first uses the impurities in air as a lasing medium [2]. Two photon

A balanced ATP driving force module for enhancing photosynthetic biosynthesis of 3-hydroxybutyrate from CO2.

PubMed

Ku, Jason T; Lan, Ethan I

2018-03-01

Using engineered photoautotrophic microorganisms for the direct chemical synthesis from CO 2 is an attractive direction for both sustainability and CO 2 mitigation. However, the behaviors of non-native metabolic pathways may be difficult to control due to the different intracellular contexts between natural and heterologous hosts. While most metabolic engineering efforts focus on strengthening driving forces in pathway design to favor biochemical production in these organisms, excessive driving force may be detrimental to product biosynthesis due to imbalanced cellular intermediate distribution. In this study, an ATP-hydrolysis based driving force module was engineered into cyanobacterium Synechococcus elongatus PCC 7942 to produce 3-hydroxybutyrate (3HB), a valuable chemical feedstock for the synthesis of biodegradable plastics and antibiotics. However, while the ATP driving force module is effective for increasing product formation, uncontrolled accumulation of intermediate metabolites likely led to metabolic imbalance and thus to cell growth inhibition. Therefore, the ATP driving force module was reengineered by providing a reversible outlet for excessive carbon flux. Upon expression of this balanced ATP driving force module with 3HB biosynthesis, engineered strain produced 3HB with a cumulative titer of 1.2 g/L, a significant increase over the initial strain. This result highlighted the importance of pathway reversibility as an effective design strategy for balancing driving force and intermediate accumulation, thereby achieving a self-regulated control for increased net flux towards product biosynthesis. Copyright © 2018 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

Comparison of forward (ear-canal) and reverse (round-window) sound stimulation of the cochlea.

PubMed

Stieger, Christof; Rosowski, John J; Nakajima, Hideko Heidi

2013-07-01

The cochlea is normally driven with "forward" stimulation, in which sound is introduced to the ear canal. Alternatively, the cochlea can be stimulated at the round window (RW) using an actuator. During RW "reverse" stimulation, the acoustic flow starting at the RW does not necessarily take the same path as during forward stimulation. To understand the differences between forward and reverse stimulation, we measured ear-canal pressure, stapes velocity, RW velocity, and intracochlear pressures in scala vestibuli (SV) and scala tympani (ST) of fresh human temporal bones. During forward stimulation, the cochlear drive (differential pressure across the partition) results from the large difference in magnitude between the pressures of SV and ST, which occurs due to the high compliance of the RW. During reverse stimulation, the relatively high impedance of the middle ear causes the pressures of SV and ST to have similar magnitudes, and the differential pressure results primarily from the difference in phase of the pressures. Furthermore, the sound path differs between forward and reverse stimulation, such that motion through a third window is more significant during reverse stimulation. Additionally, we determined that although stapes velocity is a good estimate of cochlear drive during forward stimulation, it is not a good measure during reverse stimulation. This article is part of a special issue entitled "MEMRO 2012". Copyright © 2012 Elsevier B.V. All rights reserved.

Effects of the resistivity profile on the formation of a reversed configuration and single helicity states in compressible simulations of the reversed-field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Onofri, M.; Malara, F.

2013-10-15

Compressible magnetohydrodynamics simulations of the reversed-field pinch (RFP) are presented. Previous simulations of the RFP, including density and pressure evolution, showed that a stationary state with a reversed toroidal magnetic field could not be obtained, contrary to the results produced with numerical codes neglecting density and pressure dynamics. The simulations described in the present paper show that including density and pressure evolution, a stationary RFP configuration can be obtained if the resistivity has a radial profile steeply increasing close to the wall. Such resistivity profile is more realistic than a uniform resistivity, since the temperature at the wall is lowermore » than in the plasma core.« less

49 CFR 236.746 - Feature, restoring.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Feature, restoring. An arrangement on an electro-pneumatic switch by means of which power is applied to restore the switch movement to full normal or to full reverse position, before the driving bar creeps sufficiently to unlock the switch, with control level in normal or reverse position. [49 FR 3388, Jan. 26, 1984] ...

An Evaluation of the Role of Sensory Drive in the Evolution of Lake Malawi Cichlid Fishes

PubMed Central

Smith, Adam R.; van Staaden, Moira J.; Carleton, Karen L.

2012-01-01

Although the cichlids of Lake Malawi are an important model system for the study of sensory evolution and sexual selection, the evolutionary processes linking these two phenomena remain unclear. Prior works have proposed that evolutionary divergence is driven by sensory drive, particularly as it applies to the visual system. While evidence suggests that sensory drive has played a role in the speciation of Lake Victoria cichlids, the findings from several lines of research on cichlids of Lake Malawi are not consistent with the primary tenets of this hypothesis. More specifically, three observations make the sensory drive model implausible in Malawi: (i) a lack of environmental constraint due to a broad and intense ambient light spectrum in species rich littoral habitats, (ii) pronounced variation in receiver sensory characteristics, and (iii) pronounced variability in male courtship signal characteristics. In the following work, we synthesize the results from recent studies to draw attention to the importance of sensory variation in cichlid evolution and speciation, and we suggest possible avenues of future research. PMID:22779029

Reversible vector ratchets for skyrmion systems

NASA Astrophysics Data System (ADS)

Ma, X.; Reichhardt, C. J. Olson; Reichhardt, C.

2017-03-01

We show that ac driven skyrmions interacting with an asymmetric substrate provide a realization of a class of ratchet system which we call a vector ratchet that arises due to the effect of the Magnus term on the skyrmion dynamics. In a vector ratchet, the dc motion induced by the ac drive can be described as a vector that can be rotated clockwise or counterclockwise relative to the substrate asymmetry direction. Up to a full 360∘ rotation is possible for varied ac amplitudes or skyrmion densities. In contrast to overdamped systems, in which ratchet motion is always parallel to the substrate asymmetry direction, vector ratchets allow the ratchet motion to be in any direction relative to the substrate asymmetry. It is also possible to obtain a reversal in the direction of rotation of the vector ratchet, permitting the creation of a reversible vector ratchet. We examine vector ratchets for ac drives applied parallel or perpendicular to the substrate asymmetry direction, and show that reverse ratchet motion can be produced by collective effects. No reversals occur for an isolated skyrmion on an asymmetric substrate. Since a vector ratchet can produce motion in any direction, it could represent a method for controlling skyrmion motion for spintronic applications.

Geomagnetic Field (Gmf) and Plant Evolution: Investigating the Effects of Gmf Reversal on Arabidopsis thaliana Development and Gene Expression.

PubMed

Bertea, Cinzia M; Narayana, Ravishankar; Agliassa, Chiara; Rodgers, Christopher T; Maffei, Massimo E

2015-11-30

One of the most stimulating observations in plant evolution is a correlation between the occurrence of geomagnetic field (GMF) reversals (or excursions) and the moment of the radiation of Angiosperms. This led to the hypothesis that alterations in GMF polarity may play a role in plant evolution. Here, we describe a method to test this hypothesis by exposing Arabidopsis thaliana to artificially reversed GMF conditions. We used a three-axis magnetometer and the collected data were used to calculate the magnitude of the GMF. Three DC power supplies were connected to three Helmholtz coil pairs and were controlled by a computer to alter the GMF conditions. Plants grown in Petri plates were exposed to both normal and reversed GMF conditions. Sham exposure experiments were also performed. Exposed plants were photographed during the experiment and images were analyzed to calculate root length and leaf areas. Arabidopsis total RNA was extracted and Quantitative Real Time-PCR (qPCR) analyses were performed on gene expression of CRUCIFERIN 3 (CRU3), copper transport protein1 (COTP1), Redox Responsive Transcription Factor1 (RRTF1), Fe Superoxide Dismutase 1, (FSD1), Catalase3 (CAT3), Thylakoidal Ascorbate Peroxidase (TAPX), a cytosolic Ascorbate Peroxidase1 (APX1), and NADPH/respiratory burst oxidase protein D (RbohD). Four different reference genes were analysed to normalize the results of the qPCR. The best of the four genes was selected and the most stable gene for normalization was used. Our data show for the first time that reversing the GMF polarity using triaxial coils has significant effects on plant growth and gene expression. This supports the hypothesis that GMF reversal contributes to inducing changes in plant development that might justify a higher selective pressure, eventually leading to plant evolution.

Origin, evolution, and population genetics of the selfish Segregation Distorter gene duplication in European and African populations of Drosophila melanogaster.

PubMed

Brand, Cara L; Larracuente, Amanda M; Presgraves, Daven C

2015-05-01

Meiotic drive elements are a special class of evolutionarily "selfish genes" that subvert Mendelian segregation to gain preferential transmission at the expense of homologous loci. Many drive elements appear to be maintained in populations as stable polymorphisms, their equilibrium frequencies determined by the balance between drive (increasing frequency) and selection (decreasing frequency). Here we show that a classic, seemingly balanced, drive system is instead characterized by frequent evolutionary turnover giving rise to dynamic, rather than stable, equilibrium frequencies. The autosomal Segregation Distorter (SD) system of the fruit fly Drosophila melanogaster is a selfish coadapted meiotic drive gene complex in which the major driver corresponds to a partial duplication of the gene Ran-GTPase activating protein (RanGAP). SD chromosomes segregate at similar, low frequencies of 1-5% in natural populations worldwide, consistent with a balanced polymorphism. Surprisingly, our population genetic analyses reveal evidence for parallel, independent selective sweeps of different SD chromosomes in populations on different continents. These findings suggest that, rather than persisting at a single stable equilibrium, SD chromosomes turn over frequently within populations. © 2015 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution.

CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model

PubMed Central

Zedek, František; Bureš, Petr

2016-01-01

The centromere drive model explaining rapid evolution of eukaryotic centromeres predicts higher frequency of positive selection acting on centromeric histone H3 (CenH3) in clades with asymmetric meiosis compared to the clades with only symmetric meiosis. However, despite the impression one might get from the literature, this key prediction of the centromere drive model has not only never been confirmed, but it has never been tested, because all the previous studies dealt only with the presence or absence instead of the frequency of positive selection. To provide evidence for or against different frequencies of positively selected CenH3 in asymmetrics and symmetrics, we have inferred the selective pressures acting on CenH3 in seventeen eukaryotic clades, including plants, animals, fungi, ciliates and apicomplexa, using codon-substitution models, and compared the inferred frequencies between asymmetrics and symmetrics in a quantitative manner. We have found that CenH3 has been evolving adaptively much more frequently in clades with asymmetric meiosis compared with clades displaying only symmetric meiosis which confirms the prediction of centromere drive model. Our findings indicate that the evolution of asymmetric meiosis required CenH3 to evolve adaptively more often to counterbalance the negative consequences of centromere drive. PMID:27629066

Multidimensional adaptive evolution of a feed-forward network and the illusion of compensation

PubMed Central

Bullaughey, Kevin

2016-01-01

When multiple substitutions affect a trait in opposing ways, they are often assumed to be compensatory, not only with respect to the trait, but also with respect to fitness. This type of compensatory evolution has been suggested to underlie the evolution of protein structures and interactions, RNA secondary structures, and gene regulatory modules and networks. The possibility for compensatory evolution results from epistasis. Yet if epistasis is widespread, then it is also possible that the opposing substitutions are individually adaptive. I term this possibility an adaptive reversal. Although possible for arbitrary phenotype-fitness mappings, it has not yet been investigated whether such epistasis is prevalent in a biologically-realistic setting. I investigate a particular regulatory circuit, the type I coherent feed-forward loop, which is ubiquitous in natural systems and is accurately described by a simple mathematical model. I show that such reversals are common during adaptive evolution, can result solely from the topology of the fitness landscape, and can occur even when adaptation follows a modest environmental change and the network was well adapted to the original environment. The possibility of adaptive reversals warrants a systems perspective when interpreting substitution patterns in gene regulatory networks. PMID:23289561

Self-determined mechanisms in complex networks

NASA Astrophysics Data System (ADS)

Liu, Yang; Yuan, Jian; Shan, Xiuming; Ren, Yong; Ma, Zhengxin

2008-03-01

Self-organized networks are pervasive in communication systems such as the Internet, overlay networks, peer-to-peer networks, and cluster-based services. These networks evolve into complex topologies, under specific driving forces, i.e. user demands, technological innovations, design objectives and so on. Our study focuses on the driving forces behind individual evolutions of network components, and their stimulation and domination to the self-organized networks which are defined as self-determined mechanisms in this paper. Understanding forces underlying the evolution of networks should enable informed design decisions and help to avoid unwanted surprises, such as congestion collapse. A case study on the macroscopic evolution of the Internet topology of autonomous systems under a specific driving force is then presented. Using computer simulations, it is found that the power-law degree distribution can originate from a connection preference to larger numbers of users, and that the small-world property can be caused by rapid growth in the number of users. Our results provide a new feasible perspective to understand intrinsic fundamentals in the topological evolution of complex networks.

Toward understanding of the role of reversibility of phenotypic switching in the evolution of resistance to therapy

NASA Astrophysics Data System (ADS)

Horvath, D.; Brutovsky, B.

2018-06-01

Reversibility of state transitions is intensively studied topic in many scientific disciplines over many years. In cell biology, it plays an important role in epigenetic variation of phenotypes, known as phenotypic plasticity. More interestingly, the cell state reversibility is probably crucial in the adaptation of population phenotypic heterogeneity to environmental fluctuations by evolving bet-hedging strategy, which might confer to cancer cells resistance to therapy. In this article, we propose a formalization of the evolution of highly reversible states in the environments of periodic variability. Two interrelated models of heterogeneous cell populations are proposed and their behavior is studied. The first model captures selection dynamics of the cell clones for the respective levels of phenotypic reversibility. The second model focuses on the interplay between reversibility and drug resistance in the particular case of cancer. Overall, our results show that the threshold dependencies are emergent features of the investigated model with eventual therapeutic relevance. Presented examples demonstrate importance of taking into account cell to cell heterogeneity within a system of clones with different reversibility quantified by appropriately chosen genetic and epigenetic entropy measures.

Walk and roll robot

NASA Technical Reports Server (NTRS)

Wilson, Andrew (Inventor); Punnoose, Andrew (Inventor); Strausser, Katherine (Inventor); Parikh, Neil (Inventor)

2011-01-01

A mobile robotic unit features a main body, a plurality of legs for supporting the main body on and moving the main body in forward and reverse directions about a base surface, and a drive assembly. According to an exemplary embodiment each leg includes a respective pivotal hip joint, a pivotal knee joint, and a wheeled foot adapted to roll along the base surface. Also according to an exemplary embodiments the drive assembly includes a motor operatively associated with the hip and knee joints and the wheeled foot for independently driving pivotal movement of the hip joint and the knee joint and rolling motion of the wheeled foot. The hip joint may include a ball-and-socket-type joint interconnecting top portion of the leg to the main body, such that the hip joint is adapted to pivot said leg in a direction transverse to a forward-and-reverse direction.

Fivefold confinement time increase in the Madison Symmetric Torus using inductive poloidal current drive

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoneking, M.R.; Lanier, N.E.; Prager, S.C.

1996-12-01

Current profile control is employed in the Madison Symmetric Torus reversed field pinch to reduce the magnetic fluctuations responsible for anomalous transport. An inductive poloidal electric field pulse is applied in the sense to flatten the parallel current profile, reducing the dynamo fluctuation amplitude required to sustain the equilibrium. This technique demonstrates a substantial reduction in fluctuation amplitude (as much as 50%), and improvement in energy confinement (from 1 ms to 5 ms); a record low fluctuation (0.8%) and record high temperature (615 eV) for this device were observed simultaneously during current drive experiments. Plasma beta increases by 50% andmore » the Ohmic input power is three times lower. Particle confinement improves and plasma impurity contamination is reduced. The results of the transient current drive experiments provide motivation for continuing development of steady-state current profile control strategies for the reversed field pinch.« less

Transgenerational effects of insecticides-implications for rapid pest evolution in agroecosystems.

PubMed

Brevik, Kristian; Lindström, Leena; McKay, Stephanie D; Chen, Yolanda H

2018-04-01

Although pesticides are a major selective force in driving the evolution of insect pests, the evolutionary processes that give rise to insecticide resistance remain poorly understood. Insecticide resistance has been widely observed to increase with frequent and intense insecticide exposure, but can be lost following the relaxation of insecticide use. One possible but rarely explored explanation is that insecticide resistance may be associated with epigenetic modifications, which influence the patterning of gene expression without changing underlying DNA sequence. Epigenetic modifications such as DNA methylation, histone modifications, and small RNAs have been observed to be heritable in arthropods, but their role in the context of rapid evolution of insecticide resistance remain poorly understood. Here, we discuss evidence supporting how: firstly, insecticide-induced effects can be transgenerationally inherited; secondly, epigenetic modifications are heritable; and thirdly, epigenetic modifications are responsive to pesticide and xenobiotic stress. Therefore, pesticides may drive the evolution of resistance via epigenetic processes. Moreover, insect pests primed by pesticides may be more tolerant of other stress, further enhancing their success in adapting to agroecosystems. Resolving the role of epigenetic modifications in the rapid evolution of insect pests has the potential to lead to new approaches for integrated pest management as well as improve our understanding of how anthropogenic stress may drive the evolution of insect pests. Copyright © 2018 Elsevier Inc. All rights reserved.

Useful field of view in simulated driving: Reaction times and eye movements of drivers

PubMed Central

Seya, Yasuhiro; Nakayasu, Hidetoshi; Yagi, Tadasu

2013-01-01

To examine the spatial distribution of a useful field of view (UFOV) in driving, reaction times (RTs) and eye movements were measured in simulated driving. In the experiment, a normal or mirror-reversed letter “E” was presented on driving images with different eccentricities and directions from the current gaze position. The results showed significantly slower RTs in the upper and upper left directions than in the other directions. The RTs were significantly slower in the left directions than in the right directions. These results suggest that the UFOV in driving may be asymmetrical among the meridians in the visual field. PMID:24349688

Coevolution of landesque capital intensive agriculture and sociopolitical hierarchy

PubMed Central

Sheehan, Oliver; Gray, Russell D.; Atkinson, Quentin D.

2018-01-01

One of the defining trends of the Holocene has been the emergence of complex societies. Two essential features of complex societies are intensive resource use and sociopolitical hierarchy. Although it is widely agreed that these two phenomena are associated cross-culturally and have both contributed to the rise of complex societies, the causality underlying their relationship has been the subject of longstanding debate. Materialist theories of cultural evolution tend to view resource intensification as driving the development of hierarchy, but the reverse order of causation has also been advocated, along with a range of intermediate views. Phylogenetic methods have the potential to test between these different causal models. Here we report the results of a phylogenetic study that modeled the coevolution of one type of resource intensification—the development of landesque capital intensive agriculture—with political complexity and social stratification in a sample of 155 Austronesian-speaking societies. We found support for the coevolution of landesque capital with both political complexity and social stratification, but the contingent and nondeterministic nature of both of these relationships was clear. There was no indication that intensification was the “prime mover” in either relationship. Instead, the relationship between intensification and social stratification was broadly reciprocal, whereas political complexity was more of a driver than a result of intensification. These results challenge the materialist view and emphasize the importance of both material and social factors in the evolution of complex societies, as well as the complex and multifactorial nature of cultural evolution. PMID:29555760

Correlation between driving errors and vigilance level: influence of the driver's age.

PubMed

Campagne, Aurelie; Pebayle, Thierry; Muzet, Alain

2004-01-01

During long and monotonous driving at night, most drivers progressively show signs of visual fatigue and loss of vigilance. Their capacity to maintain adequate driving performance usually is affected and varies with the age of the driver. The main question is to know, on one hand, if occurrence of fatigue and drowsiness is accompanied by a modification in the driving performance of the driver and, on the other hand, if this relationship partially depends on the driver's age. Forty-six male drivers, divided into three age categories: 20-30, 40-50, and 60-70 years, performed a 350-km motorway driving session at night on a driving simulator. Driving errors were measured in terms of number of running-off-the-road incidents (RORI) and large speed deviations. The evolution of physiological vigilance level was evaluated using electroencephalography (EEG) recording. In older drivers, in comparison with young and middle-aged drivers, the degradation of driving performance was correlated to the evolution of lower frequency waking EEG (i.e., theta). Contrary to young and middle-aged drivers, the deterioration of the vigilance level attested by EEG correlated with the increase in gravity of all studied driving errors in older drivers. Thus, depending on the age category considered, only part of the driving errors would constitute a relevant indication as for the occurrence of a state of low arousal.

Microorganism and filamentous fungi drive evolution of plant synapses.

PubMed

Baluška, František; Mancuso, Stefano

2013-01-01

In the course of plant evolution, there is an obvious trend toward an increased complexity of plant bodies, as well as an increased sophistication of plant behavior and communication. Phenotypic plasticity of plants is based on the polar auxin transport machinery that is directly linked with plant sensory systems impinging on plant behavior and adaptive responses. Similar to the emergence and evolution of eukaryotic cells, evolution of land plants was also shaped and driven by infective and symbiotic microorganisms. These microorganisms are the driving force behind the evolution of plant synapses and other neuronal aspects of higher plants; this is especially pronounced in the root apices. Plant synapses allow synaptic cell-cell communication and coordination in plants, as well as sensory-motor integration in root apices searching for water and mineral nutrition. These neuronal aspects of higher plants are closely linked with their unique ability to adapt to environmental changes.

Microorganism and filamentous fungi drive evolution of plant synapses

PubMed Central

Baluška, František; Mancuso, Stefano

2013-01-01

In the course of plant evolution, there is an obvious trend toward an increased complexity of plant bodies, as well as an increased sophistication of plant behavior and communication. Phenotypic plasticity of plants is based on the polar auxin transport machinery that is directly linked with plant sensory systems impinging on plant behavior and adaptive responses. Similar to the emergence and evolution of eukaryotic cells, evolution of land plants was also shaped and driven by infective and symbiotic microorganisms. These microorganisms are the driving force behind the evolution of plant synapses and other neuronal aspects of higher plants; this is especially pronounced in the root apices. Plant synapses allow synaptic cell–cell communication and coordination in plants, as well as sensory-motor integration in root apices searching for water and mineral nutrition. These neuronal aspects of higher plants are closely linked with their unique ability to adapt to environmental changes. PMID:23967407

Relative importance of natural and anthropogenic factors influencing karst rocky desertification

NASA Astrophysics Data System (ADS)

Xu, Erqi; Zhang, Hongqi

2017-04-01

As the most severe ecological issue in southwest China, karst rocky desertification (KRD) has both threatened and constrained regional sustainable development. Comprehensively understanding the relationship between the evolution of KRD and relevant driving data would provide more information to combat KRD in such complex karst environments. Past studies have been limited in quantifying the relative importance of driving factors influencing fine-scale KRD evolution, and have also lacked insight into their interactive impacts. To address these issues, we have used geographical information system techniques and a geographical detector model to explore the spatial consistency of driving factors and their interactions in relation to the evolution of KRD. Changshun County in China was selected as a representative area for the study. Nine relevant driving factors, including both natural and anthropogenic factors, were studied in regard to their relationships with KRD transformation between 2000 and 2010. Our results demonstrate the relative importance of driving data in influencing the improvement and deterioration of KRD. Lithology, soil type and road influence are identified as the leading factors. Interestingly, to our study at least, there is no significant difference between the impacts of natural and anthropogenic factors influencing KRD improvement, and even natural factors have a higher impact on KRD deterioration. Factors were found to enhance the influence of each other for KRD transformation. In particular, the results show a non-linearly enhanced effect between driving factors, which significantly aggravates KRD. New information found in our study helps to effectively control and restore areas afflicted by KRD.

Precision wire feeder for small diameter wire

DOEpatents

Brandon, Eldon D.; Hooper, Frederick M.; Reichenbach, Marvin L.

1992-01-01

A device for feeding small diameter wire having a diameter less than 0.04 mm (16 mil) to a welding station includes a driving wheel for controllably applying a non-deforming driving force to the wire to move the free end of the wire towards the welding station; and a tension device such as a torque motor for constantly applying a reverse force to the wire in opposition to the driving force to keep the wire taut.

Precision wire feeder for small diameter wire

DOEpatents

Brandon, E.D.; Hooper, F.M.; Reichenbach, M.L.

1992-08-11

A device for feeding small diameter wire having a diameter less than 0.04 mm (16 mil) to a welding station includes a driving wheel for controllably applying a non-deforming driving force to the wire to move the free end of the wire towards the welding station; and a tension device such as a torque motor for constantly applying a reverse force to the wire in opposition to the driving force to keep the wire taut. 1 figure.

Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus.

PubMed

Tyzio, Roman; Minlebaev, Marat; Rheims, Sylvain; Ivanov, Anton; Jorquera, Isabelle; Holmes, Gregory L; Zilberter, Yuri; Ben-Ari, Yehezkiel; Khazipov, Rustem

2008-05-01

During postnatal development of the rat hippocampus, gamma-aminobutyric acid (GABA) switches its action on CA3 pyramidal cells from excitatory to inhibitory. To characterize the underlying changes in the GABA reversal potential, we used somatic cell-attached recordings of GABA(A) and N-methyl-D-aspartate channels to monitor the GABA driving force and resting membrane potential, respectively. We found that the GABA driving force is strongly depolarizing during the first postnatal week. The strength of this depolarization rapidly declines with age, although GABA remains slightly depolarizing, by a few millivolts, even in adult neurons. Reduction in the depolarizing GABA driving force was due to a progressive negative shift of the reversal potential of GABA currents. Similar postnatal changes in GABA signalling were also observed using the superfused hippocampus preparation in vivo, and in the hippocampal interneurons in vitro. We also found that in adult pyramidal cells, somatic GABA reversal potential is maintained at a slightly depolarizing level by bicarbonate conductance, chloride-extrusion and chloride-loading systems. Thus, the postnatal excitatory-to-inhibitory switch in somatic GABA signalling is associated with a negative shift of the GABA reversal potential but without a hyperpolarizing switch in the polarity of GABA responses. These results also suggest that in adult CA3 pyramidal cells, somatic GABAergic inhibition takes place essentially through shunting rather than hyperpolarization. Apparent hyperpolarizing GABA responses previously reported in the soma of CA3 pyramidal cells are probably due to cell depolarization during intracellular or whole-cell recordings.

ECOLOGICAL AND EVOLUTIONARY APPLICATIONS FOR ENVIRONMENTAL SEX REVERSAL OF FISH.

PubMed

Mcnair, Alistair; Lokman, P Mark; Closs, Gerard P; Nakagawa, Shinichi

2015-03-01

Environmental sex reversal (ESR), which results in a mismatch between genotypic and phenotypic sex, is well documented in numerous fish species and may be induced by chemical exposure. Historically, research involving piscine ESR has been carried out with a view to improving profitability in aquaculture or to elucidate the processes governing sex determination and sexual differentiation. However, recent studies in evolution and ecology suggest research on ESR now has much wider applications and ramifications. We begin with an overview of ESR in fish and a brief review of the traditional applications thereof. We then discuss ESR and its potential demographic consequences in wild populations. Theory even suggests sex-reversed fish may be purposefully released to manipulate population dynamics. We suggest new research directions that may prove fruitful in understanding how ESR at the individual level translates to population-level processes. In the latter portion of the review we focus on evolutionary applications of ESR. Sex-reversal studies from the aquaculture literature provide insight in to the evolvability of determinants of sexual phenotype. Additionally, induced sex reversal can provide information about the evolution of sex chromosomes and sex-linked traits. Recently, naturally occurring ESR has been implicated as a mechanism contributing to the evolution of sex chromosomes.

Visualizing Clonal Evolution in Cancer.

PubMed

Krzywinski, Martin

2016-06-02

Rapid and inexpensive single-cell sequencing is driving new visualizations of cancer instability and evolution. Krzywinski discusses how to present clone evolution plots in order to visualize temporal, phylogenetic, and spatial aspects of a tumor in a single static image. Copyright © 2016 Elsevier Inc. All rights reserved.

Reversible amorphization and the catalytically active state of crystalline Co3O4 during oxygen evolution

PubMed Central

Bergmann, Arno; Martinez-Moreno, Elias; Teschner, Detre; Chernev, Petko; Gliech, Manuel; de Araújo, Jorge Ferreira; Reier, Tobias; Dau, Holger; Strasser, Peter

2015-01-01

Water splitting catalysed by earth-abundant materials is pivotal for global-scale production of non-fossil fuels, yet our understanding of the active catalyst structure and reactivity is still insufficient. Here we report on the structurally reversible evolution of crystalline Co3O4 electrocatalysts during oxygen evolution reaction identified using advanced in situ X-ray techniques. At electrode potentials facilitating oxygen evolution, a sub-nanometre shell of the Co3O4 is transformed into an X-ray amorphous CoOx(OH)y which comprises di-μ-oxo-bridged Co3+/4+ ions. Unlike irreversible amorphizations, here, the formation of the catalytically-active layer is reversed by re-crystallization upon return to non-catalytic electrode conditions. The Co3O4 material thus combines the stability advantages of a controlled, stable crystalline material with high catalytic activity, thanks to the structural flexibility of its active amorphous oxides. We propose that crystalline oxides may be tailored for generating reactive amorphous surface layers at catalytic potentials, just to return to their stable crystalline state under rest conditions. PMID:26456525

Reversible amorphization and the catalytically active state of crystalline Co3O4 during oxygen evolution.

PubMed

Bergmann, Arno; Martinez-Moreno, Elias; Teschner, Detre; Chernev, Petko; Gliech, Manuel; de Araújo, Jorge Ferreira; Reier, Tobias; Dau, Holger; Strasser, Peter

2015-10-12

Water splitting catalysed by earth-abundant materials is pivotal for global-scale production of non-fossil fuels, yet our understanding of the active catalyst structure and reactivity is still insufficient. Here we report on the structurally reversible evolution of crystalline Co3O4 electrocatalysts during oxygen evolution reaction identified using advanced in situ X-ray techniques. At electrode potentials facilitating oxygen evolution, a sub-nanometre shell of the Co3O4 is transformed into an X-ray amorphous CoOx(OH)y which comprises di-μ-oxo-bridged Co(3+/4+) ions. Unlike irreversible amorphizations, here, the formation of the catalytically-active layer is reversed by re-crystallization upon return to non-catalytic electrode conditions. The Co3O4 material thus combines the stability advantages of a controlled, stable crystalline material with high catalytic activity, thanks to the structural flexibility of its active amorphous oxides. We propose that crystalline oxides may be tailored for generating reactive amorphous surface layers at catalytic potentials, just to return to their stable crystalline state under rest conditions.

Conditional dynamics driving financial markets

NASA Astrophysics Data System (ADS)

Boguñá, M.; Masoliver, J.

2004-08-01

We revisit the problem of daily correlations in speculative prices and report empirical evidences on the existence of what we term a conditional or dual dynamics driving the evolution of financial assets. This dynamics is detected in several markets around the world and for different historical periods. In particular, we have analyzed the DJIA database from 1900 to 2002 as well as 65 companies trading in the LIFFE market of futures and 12 of the major European and American treasury bonds. In all cases, we find a twofold dynamics driving the financial evolution depending on whether the previous price went up or down. We conjecture that this effect is universal and intrinsic to all markets.

Meiotic drive impacts expression and evolution of x-linked genes in stalk-eyed flies.

PubMed

Reinhardt, Josephine A; Brand, Cara L; Paczolt, Kimberly A; Johns, Philip M; Baker, Richard H; Wilkinson, Gerald S

2014-01-01

Although sex chromosome meiotic drive has been observed in a variety of species for over 50 years, the genes causing drive are only known in a few cases, and none of these cases cause distorted sex-ratios in nature. In stalk-eyed flies (Teleopsis dalmanni), driving X chromosomes are commonly found at frequencies approaching 30% in the wild, but the genetic basis of drive has remained elusive due to reduced recombination between driving and non-driving X chromosomes. Here, we used RNAseq to identify transcripts that are differentially expressed between males carrying either a driving X (XSR) or a standard X chromosome (XST), and found hundreds of these, the majority of which are X-linked. Drive-associated transcripts show increased levels of sequence divergence (dN/dS) compared to a control set, and are predominantly expressed either in testes or in the gonads of both sexes. Finally, we confirmed that XSR and XST are highly divergent by estimating sequence differentiation between the RNAseq pools. We found that X-linked transcripts were often strongly differentiated (whereas most autosomal transcripts were not), supporting the presence of a relatively large region of recombination suppression on XSR presumably caused by one or more inversions. We have identified a group of genes that are good candidates for further study into the causes and consequences of sex-chromosome drive, and demonstrated that meiotic drive has had a profound effect on sequence evolution and gene expression of X-linked genes in this species.

Ancestral state reconstructions require biological evidence to test evolutionary hypotheses: A case study examining the evolution of reproductive mode in squamate reptiles.

PubMed

Griffith, Oliver W; Blackburn, Daniel G; Brandley, Matthew C; Van Dyke, James U; Whittington, Camilla M; Thompson, Michael B

2015-09-01

To understand evolutionary transformations it is necessary to identify the character states of extinct ancestors. Ancestral character state reconstruction is inherently difficult because it requires an accurate phylogeny, character state data, and a statistical model of transition rates and is fundamentally constrained by missing data such as extinct taxa. We argue that model based ancestral character state reconstruction should be used to generate hypotheses but should not be considered an analytical endpoint. Using the evolution of viviparity and reversals to oviparity in squamates as a case study, we show how anatomical, physiological, and ecological data can be used to evaluate hypotheses about evolutionary transitions. The evolution of squamate viviparity requires changes to the timing of reproductive events and the successive loss of features responsible for building an eggshell. A reversal to oviparity requires that those lost traits re-evolve. We argue that the re-evolution of oviparity is inherently more difficult than the reverse. We outline how the inviability of intermediate phenotypes might present physiological barriers to reversals from viviparity to oviparity. Finally, we show that ecological data supports an oviparous ancestral state for squamates and multiple transitions to viviparity. In summary, we conclude that the first squamates were oviparous, that frequent transitions to viviparity have occurred, and that reversals to oviparity in viviparous lineages either have not occurred or are exceedingly rare. As this evidence supports conclusions that differ from previous ancestral state reconstructions, our paper highlights the importance of incorporating biological evidence to evaluate model-generated hypotheses. © 2015 Wiley Periodicals, Inc.

Dynamic self-guiding analysis of Alzheimer's disease

PubMed Central

Kurakin, Alexei; Bredesen, Dale E.

2015-01-01

We applied a self-guiding evolutionary algorithm to initiate the synthesis of the Alzheimer's disease-related data and literature. A protein interaction network associated with amyloid-beta precursor protein (APP) and a seed model that treats Alzheimer's disease as progressive dysregulation of APP-associated signaling were used as dynamic “guides” and structural “filters” in the recursive search, analysis, and assimilation of data to drive the evolution of the seed model in size, detail, and complexity. Analysis of data and literature across sub-disciplines and system-scale discovery platforms suggests a key role of dynamic cytoskeletal connectivity in the stability, plasticity, and performance of multicellular networks and architectures. Chronic impairment and/or dysregulation of cell adhesions/synapses, cytoskeletal networks, and/or reversible epithelial-to-mesenchymal-like transitions, which enable and mediate the stable and coherent yet dynamic and reconfigurable multicellular architectures, may lead to the emergence and persistence of the disordered, wound-like pockets/microenvironments of chronically disconnected cells. Such wound-like microenvironments support and are supported by pro-inflammatory, pro-secretion, de-differentiated cellular phenotypes with altered metabolism and signaling. The co-evolution of wound-like microenvironments and their inhabitants may lead to the selection and stabilization of degenerated cellular phenotypes, via acquisition of epigenetic modifications and mutations, which eventually result in degenerative disorders such as cancer and Alzheimer's disease. PMID:26041885

MBE Growth of InN/GaN(0001) and Shape Transitions of InN islands

NASA Astrophysics Data System (ADS)

Cao, Yongge; Xie, Maohai; Liu, Ying; Ng, Y. F.

2003-03-01

Plasma-assisted molecular-beam epitaxial growth of InN on GaN(0001) is investigated. Both layer-by-layer and Stranski-Krastanov (SK) growth modes are observed under different growth windows. Strain relaxation is studied by real-time recording of the in-plane lattice spacing evolutions on RHEED pattern, which suggest a gradual relaxation of the strain in InN film commenced during the first bilayer (BL) deposition and almost completed after 2-4 BLs. For SK growth, 3D islanding initiates after the strain has mostly been relieved, presumably by dislocations. Based on statistical analysis, the shape transitions of 3D islands are firstly observed in the III-nitrides system. The InN islands transform gradually from pyramids to platelets with increasing of In flux. Under In-rich growth condition, the reverse trend of island shape evolution dependence on volume size, compared with Equilibrium Crystal Shape (ECS) theory, is induced by the Indium self-surfactant effects, in which Indium adlayer on the top surface of InN islands will depress the thermodynamic driving force for the vertical growth of 3D islands. Lateral growth of 3D islands is not only the result of kinetic process but also favored by thermodynamics while Indium self-surfactant exist.

Observation of strong oscillations of areal mass in an unsupported shock wave produced by a short laser pulse

NASA Astrophysics Data System (ADS)

Aglitskiy, Y.; Karasik, M.; Velikovich, A. L.; Serlin, V.; Weaver, J. L.; Kessler, T. J.; Schmitt, A. J.; Obenschain, S. P.; Metzler, N.; Oh, J.

2011-10-01

The first experimental study of hydrodynamic perturbation evolution in a strong unsupported shock wave, which is immediately followed by a rarefaction wave, is reported. Our planar solid polystyrene laser-machined targets, 50 to 100 μm thick, rippled from the front side with a single-mode wavelength 30 or 45 μm and peak-to-valley amplitude 4 to 6 μm, were irradiated with a 350 ps long Nike KrF laser pulse at peak intensity of up to 330 TW/cm2. The perturbation evolution in the target was observed using face-on monochromatic x-ray radiography while the pulse lasted and for 3 to 4 ns after it ended. While the driving pulse was on, the areal mass modulation amplitude in the target was observed to grow by a factor of up to ~4 due to the ablative Richtmyer-Meshkov instability. After the end of the pulse, while the strong unsupported shock wave propagated through the unperturbed target, the theoretically predicted large oscillations of the areal mass [A. L. Velikovich et al., Phys. Plasmas 10, 3270 (2003)] were observed. Multiple phase reversals of the areal mass modulation have been detected. Work supported by DOE/NNSA and Office of Naval Research.

Alpha effect of Alfv{acute e}n waves and current drive in reversed-field pinches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litwin, C.; Prager, S.C.

Circularly polarized Alfv{acute e}n waves give rise to an {alpha}-dynamo effect that can be exploited to drive parallel current. In a {open_quotes}laminar{close_quotes} magnetic the effect is weak and does not give rise to significant currents for realistic parameters (e.g., in tokamaks). However, in reversed-field pinches (RFPs) in which magnetic field in the plasma core is stochastic, a significant enhancement of the {alpha} effect occurs. Estimates of this effect show that it may be a realistic method of current generation in the present-day RFP experiments and possibly also in future RFP-based fusion reactors. {copyright} {ital 1998 American Institute of Physics.}

Exploring metazoan evolution through dynamic and holistic changes in protein families and domains

USDA-ARS?s Scientific Manuscript database

Understanding proteome evolution is important for deciphering processes that drive species diversity and adaptation. Herein, the dynamics of change in protein families and protein domains over the course of metazoan evolution was explored. Change, as defined by birth/death and duplication/deletion ...

Ultralow drive voltage silicon traveling-wave modulator.

PubMed

Baehr-Jones, Tom; Ding, Ran; Liu, Yang; Ayazi, Ali; Pinguet, Thierry; Harris, Nicholas C; Streshinsky, Matt; Lee, Poshen; Zhang, Yi; Lim, Andy Eu-Jin; Liow, Tsung-Yang; Teo, Selin Hwee-Gee; Lo, Guo-Qiang; Hochberg, Michael

2012-05-21

There has been great interest in the silicon platform as a material system for integrated photonics. A key challenge is the development of a low-power, low drive voltage, broadband modulator. Drive voltages at or below 1 Vpp are desirable for compatibility with CMOS processes. Here we demonstrate a CMOS-compatible broadband traveling-wave modulator based on a reverse-biased pn junction. We demonstrate operation with a drive voltage of 0.63 Vpp at 20 Gb/s, a significant improvement in the state of the art, with an RF energy consumption of only 200 fJ/bit.

Reversible Gene Drive Mechanism Utilizing Trana Inactivating Paramutatlons In Insects (paramutale 0.9)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drocco, Jeffery A.

The paramutate software package Is a tool to calculate the genotyplc and phenotyplc propagation of a gene drive that can be silenced with a homologuus trans-Inactivating panmutatlon, ln dlptera or other species with a slmUar-acttng pl RNA system/Plwi pathway. Method of SolaUon: paramutate uses rults of Mendelian, gene drive (I.e.. stimulated conversion), and maternal Inheritance to compute the propaptlon of a notional gene drive construct and Its trans-lnactlvat1n1 paramutatlon, throu1b a panmlctlc, fixed-size population reproducing In synchronous generations.

AST: Activity-Security-Trust driven modeling of time varying networks.

PubMed

Wang, Jian; Xu, Jiake; Liu, Yanheng; Deng, Weiwen

2016-02-18

Network modeling is a flexible mathematical structure that enables to identify statistical regularities and structural principles hidden in complex systems. The majority of recent driving forces in modeling complex networks are originated from activity, in which an activity potential of a time invariant function is introduced to identify agents' interactions and to construct an activity-driven model. However, the new-emerging network evolutions are already deeply coupled with not only the explicit factors (e.g. activity) but also the implicit considerations (e.g. security and trust), so more intrinsic driving forces behind should be integrated into the modeling of time varying networks. The agents undoubtedly seek to build a time-dependent trade-off among activity, security, and trust in generating a new connection to another. Thus, we reasonably propose the Activity-Security-Trust (AST) driven model through synthetically considering the explicit and implicit driving forces (e.g. activity, security, and trust) underlying the decision process. AST-driven model facilitates to more accurately capture highly dynamical network behaviors and figure out the complex evolution process, allowing a profound understanding of the effects of security and trust in driving network evolution, and improving the biases induced by only involving activity representations in analyzing the dynamical processes.

The Phelix Pulsed Power Project: Bringing Portable Magnetic Drive to World Class Radiography

DTIC Science & Technology

2011-06-01

vitreous carbon damping resistors are used on the output headers of each module for a total of 25.1 mΩ of resistance. Figure 6. The PHELIX portable...4 MA peak current in the secondary winding for driving a liner. In order to not produce too much reverse voltage on the capacitors, reticulated

Reversible vector ratchets for skyrmion systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Xiu; Reichhardt, Cynthia Jane Olson; Reichhardt, Charles

In this paper, we show that ac driven skyrmions interacting with an asymmetric substrate provide a realization of a class of ratchet system which we call a vector ratchet that arises due to the effect of the Magnus term on the skyrmion dynamics. In a vector ratchet, the dc motion induced by the ac drive can be described as a vector that can be rotated clockwise or counterclockwise relative to the substrate asymmetry direction. Up to a full 360° rotation is possible for varied ac amplitudes or skyrmion densities. In contrast to overdamped systems, in which ratchet motion is alwaysmore » parallel to the substrate asymmetry direction, vector ratchets allow the ratchet motion to be in any direction relative to the substrate asymmetry. It is also possible to obtain a reversal in the direction of rotation of the vector ratchet, permitting the creation of a reversible vector ratchet. We examine vector ratchets for ac drives applied parallel or perpendicular to the substrate asymmetry direction, and show that reverse ratchet motion can be produced by collective effects. No reversals occur for an isolated skyrmion on an asymmetric substrate. Finally, since a vector ratchet can produce motion in any direction, it could represent a method for controlling skyrmion motion for spintronic applications.« less

Reversible vector ratchets for skyrmion systems

DOE PAGES

Ma, Xiu; Reichhardt, Cynthia Jane Olson; Reichhardt, Charles

2017-03-03

In this paper, we show that ac driven skyrmions interacting with an asymmetric substrate provide a realization of a class of ratchet system which we call a vector ratchet that arises due to the effect of the Magnus term on the skyrmion dynamics. In a vector ratchet, the dc motion induced by the ac drive can be described as a vector that can be rotated clockwise or counterclockwise relative to the substrate asymmetry direction. Up to a full 360° rotation is possible for varied ac amplitudes or skyrmion densities. In contrast to overdamped systems, in which ratchet motion is alwaysmore » parallel to the substrate asymmetry direction, vector ratchets allow the ratchet motion to be in any direction relative to the substrate asymmetry. It is also possible to obtain a reversal in the direction of rotation of the vector ratchet, permitting the creation of a reversible vector ratchet. We examine vector ratchets for ac drives applied parallel or perpendicular to the substrate asymmetry direction, and show that reverse ratchet motion can be produced by collective effects. No reversals occur for an isolated skyrmion on an asymmetric substrate. Finally, since a vector ratchet can produce motion in any direction, it could represent a method for controlling skyrmion motion for spintronic applications.« less

Myxococcus xanthus Swarms Are Driven by Growth and Regulated by a Pacemaker ▿

PubMed Central

Kaiser, Dale; Warrick, Hans

2011-01-01

The principal social activity of Myxococcus xanthus is to organize a dynamic multicellular structure, known as a swarm. Although its cell density is high, the swarm can grow and expand rapidly. Within the swarm, the individual rod-shaped cells are constantly moving, transiently interacting with one another, and independently reversing their gliding direction. Periodic reversal is, in fact, essential for creating a swarm, and the reversal frequency controls the rate of swarm expansion. Chemotaxis toward nutrient has been thought to drive swarming, but here the nature of swarm growth and the impact of genetic deletions of members of the Frz family of proteins suggest otherwise. We find that three cytoplasmic Frz proteins, FrzCD, FrzF, and FrzE, constitute a cyclic pathway that sets the reversal frequency. Within each cell these three proteins appear to be connected in a negative-feedback loop that produces oscillations whose frequencies are finely tuned by methylation and by phosphorylation. This oscillator, in turn, drives MglAB, a small G-protein switch, to oscillate between its GTP- and GDP-bound states that ultimately determine when the cell moves forward or backward. The periodic reversal of interacting rod-shaped cells promotes their alignment. Swarm organization ensures that each cell can move without blocking the movement of others. PMID:21856842

Evolution of CAM and C4 carbon-concentrating mechanisms

USGS Publications Warehouse

Keeley, Jon E.; Rundel, Philip W.

2003-01-01

Mechanisms for concentrating carbon around the Rubisco enzyme, which drives the carbon-reducing steps in photosynthesis, are widespread in plants; in vascular plants they are known as crassulacean acid metabolism (CAM) and C4 photosynthesis. CAM is common in desert succulents, tropical epiphytes, and aquatic plants and is characterized by nighttime fixation of CO2. The proximal selective factor driving the evolution of this CO2-concentrating pathway is low daytime CO2, which results from the unusual reverse stomatal behavior of terrestrial CAM species or from patterns of ambient CO2 availability for aquatic CAM species. In terrestrials the ultimate selective factor is water stress that has selected for increased water use efficiency. In aquatics the ultimate selective factor is diel fluctuations in CO2 availability for palustrine species and extreme oligotrophic conditions for lacustrine species. C4 photosynthesis is based on similar biochemistry but carboxylation steps are spatially separated in the leaf rather than temporally as in CAM. This biochemical pathway is most commonly associated with a specialized leaf anatomy known as Kranz anatomy; however, there are exceptions. The ultimate selective factor driving the evolution of this pathway is excessively high photorespiration that inhibits normal C3 photosynthesis under high light and high temperature in both terrestrial and aquatic habitats. CAM is an ancient pathway that likely has been present since the Paleozoic era in aquatic species from shallow-water palustrine habitats. While atmospheric CO2 levels have undoubtedly affected the evolution of terrestrial plant carbon-concentrating mechanisms, there is reason to believe that past atmospheric changes have not played as important a selective role in the aquatic milieu since palustrine habitats today are not generally carbon sinks, and the selective factors driving aquatic CAM are autogenic. Terrestrial CAM, in contrast, is of increasing selective value under extreme water deficits, and undoubtedly, high Mesozoic CO2 levels reduced the amount of landscape perceived by plants as water limited. Late Tertiary and Quaternary reductions in atmospheric CO2, coupled with increasing seasonality, were probably times of substantial species radiation and ecological expansion for CAM plants. C4 photosynthesis occurs in only about half as many families as CAM, and three-fourths of C4 species are either grasses or sedges. Molecular phylogenies indicate C4 is a more recent innovation than CAM and that it originated in the mid-Tertiary, 20–30 Ma, although some data support an earlier origin. While the timing of the origin of C4 remains controversial, the nearly explosive increase in C4 species is clearly documented in the late Miocene, 4–7 Ma. Increasing seasonality has been widely suggested as an important climatic stimulus for this C4 expansion. Alternatively, based on models of photosynthetic quantum yield at different temperatures and CO2 concentration, it has been hypothesized that the late Miocene C4 expansion resulted from declining atmospheric CO2 levels. This model is most appropriate for explaining the transition from C3 grasslands to C4 grasslands but by itself may not be sufficient to explain the more likely scenario of a late Miocene transition from C3 woodland/ savanna to C4 grasslands. A largely unexplored hypothesis is that climatic changes in late Miocene altered disturbance regimes, in particular the incidence of fires, which today are often associated with maintenance of C4 grasslands. Oceanic charcoal sediments that appear to represent Aeolian deposits from continental wildfires follow a strikingly similar pattern of explosive increase in late Miocene. Climate, CO2, and disturbance are not mutually exclusive explanations and probably all acted in concert to promote the expansion of C4 grasslands. More recently, late Quaternary changes in CO2 may have been responsible for driving major changes in the landscape distribution of C4 species. The theory is sound; however, many of the studies cited in support of this model are open to alternative interpretations, and none has eliminated climatic factors as important selective agents. CAM and C4 evolution required coupling of biochemical pathways with structural changes in photosynthetic tissues, succulence in CAM and Kranz in C4. This was apparently accomplished by piecemeal evolution beginning with mechanisms for recapturing respiratory CO2, although this need not have been so in aquatic CAM species. It has been proposed that the extreme rarity of both pathways in the same plant results from biochemical and structural incompatibilities (Sage 2002). Equally important is the fact that the selective environments are quite different, with CAM evolution thriving on stressful sites inhospitable to C3 species whereas C4 evolution has selected for rapid growth capable of outcompeting associated C3 plants.

Protein thin film machines

NASA Astrophysics Data System (ADS)

Federici, Stefania; Oliviero, Giulio; Hamad-Schifferli, Kimberly; Bergese, Paolo

2010-12-01

We report the first example of microcantilever beams that are reversibly driven by protein thin film machines fuelled by cycling the salt concentration of the surrounding solution. We also show that upon the same salinity stimulus the drive can be completely reversed in its direction by introducing a surface coating ligand. Experimental results are throughout discussed within a general yet simple thermodynamic model.

The evolution of sex roles in birds is related to adult sex ratio.

PubMed

Liker, András; Freckleton, Robert P; Székely, Tamás

2013-01-01

Sex-role reversal represents a formidable challenge for evolutionary biologists, since it is not clear which ecological, life-history or social factors facilitated conventional sex roles (female care and male-male competition for mates) to be reversed (male care and female-female competition). Classic theories suggested ecological or life-history predictors of role reversal, but most studies failed to support these hypotheses. Recent theory however predicts that sex-role reversal should be driven by male-biased adult sex ratio (ASR). Here we test this prediction for the first time using phylogenetic comparative analyses. Consistent with theory, both mating system and parental care are strongly related to ASR in shorebirds: conventional sex roles are exhibited by species with female-biased ASR, whereas sex-role reversal is associated with male-biased ASR. These results suggest that social environment has a strong influence on breeding systems and therefore revealing the causes of ASR variation in wild populations is essential for understanding sex role evolution.

Driving simulator sickness: Impact on driving performance, influence of blood alcohol concentration, and effect of repeated simulator exposures.

PubMed

Helland, Arne; Lydersen, Stian; Lervåg, Lone-Eirin; Jenssen, Gunnar D; Mørland, Jørg; Slørdal, Lars

2016-09-01

Simulator sickness is a major obstacle to the use of driving simulators for research, training and driver assessment purposes. The purpose of the present study was to investigate the possible influence of simulator sickness on driving performance measures such as standard deviation of lateral position (SDLP), and the effect of alcohol or repeated simulator exposure on the degree of simulator sickness. Twenty healthy male volunteers underwent three simulated driving trials of 1h's duration with a curvy rural road scenario, and rated their degree of simulator sickness after each trial. Subjects drove sober and with blood alcohol concentrations (BAC) of approx. 0.5g/L and 0.9g/L in a randomized order. Simulator sickness score (SSS) did not influence the primary outcome measure SDLP. Higher SSS significantly predicted lower average speed and frequency of steering wheel reversals. These effects seemed to be mitigated by alcohol. Higher BAC significantly predicted lower SSS, suggesting that alcohol inebriation alleviates simulator sickness. The negative relation between the number of previous exposures to the simulator and SSS was not statistically significant, but is consistent with habituation to the sickness-inducing effects, as shown in other studies. Overall, the results suggest no influence of simulator sickness on SDLP or several other driving performance measures. However, simulator sickness seems to cause test subjects to drive more carefully, with lower average speed and fewer steering wheel reversals, hampering the interpretation of these outcomes as measures of driving impairment and safety. BAC and repeated simulator exposures may act as confounding variables by influencing the degree of simulator sickness in experimental studies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Magnetic field evolution and reversals in spiral galaxies

NASA Astrophysics Data System (ADS)

Dobbs, C. L.; Price, D. J.; Pettitt, A. R.; Bate, M. R.; Tricco, T. S.

2016-10-01

We study the evolution of galactic magnetic fields using 3D smoothed particle magnetohydrodynamics (SPMHD) simulations of galaxies with an imposed spiral potential. We consider the appearance of reversals of the field, and amplification of the field. We find that magnetic field reversals occur when the velocity jump across the spiral shock is above ≈20 km s-1, occurring where the velocity change is highest, typically at the inner Lindblad resonance in our models. Reversals also occur at corotation, where the direction of the velocity field reverses in the corotating frame of a spiral arm. They occur earlier with a stronger amplitude spiral potential, and later or not at all with weaker or no spiral arms. The presence of a reversal at radii of around 4-6 kpc in our fiducial model is consistent with a reversal identified in the Milky Way, though we caution that alternative Galaxy models could give a similar reversal. We find that relatively high resolution, a few million particles in SPMHD, is required to produce consistent behaviour of the magnetic field. Amplification of the magnetic field occurs in the models, and while some may be genuinely attributable to differential rotation or spiral arms, some may be a numerical artefact. We check our results using ATHENA, finding reversals but less amplification of the field, suggesting that some of the amplification of the field with SPMHD is numerical.

Geomagnetic Field (Gmf) and Plant Evolution: Investigating the Effects of Gmf Reversal on Arabidopsis thaliana Development and Gene Expression

PubMed Central

Bertea, Cinzia M.; Narayana, Ravishankar; Agliassa, Chiara; Rodgers, Christopher T.; Maffei, Massimo E.

2015-01-01

One of the most stimulating observations in plant evolution is a correlation between the occurrence of geomagnetic field (GMF) reversals (or excursions) and the moment of the radiation of Angiosperms. This led to the hypothesis that alterations in GMF polarity may play a role in plant evolution. Here, we describe a method to test this hypothesis by exposing Arabidopsis thaliana to artificially reversed GMF conditions. We used a three-axis magnetometer and the collected data were used to calculate the magnitude of the GMF. Three DC power supplies were connected to three Helmholtz coil pairs and were controlled by a computer to alter the GMF conditions. Plants grown in Petri plates were exposed to both normal and reversed GMF conditions. Sham exposure experiments were also performed. Exposed plants were photographed during the experiment and images were analyzed to calculate root length and leaf areas. Arabidopsis total RNA was extracted and Quantitative Real Time-PCR (qPCR) analyses were performed on gene expression of CRUCIFERIN 3 (CRU3), copper transport protein1 (COTP1), Redox Responsive Transcription Factor1 (RRTF1), Fe Superoxide Dismutase 1, (FSD1), Catalase3 (CAT3), Thylakoidal Ascorbate Peroxidase (TAPX), a cytosolic Ascorbate Peroxidase1 (APX1), and NADPH/respiratory burst oxidase protein D (RbohD). Four different reference genes were analysed to normalize the results of the qPCR. The best of the four genes was selected and the most stable gene for normalization was used. Our data show for the first time that reversing the GMF polarity using triaxial coils has significant effects on plant growth and gene expression. This supports the hypothesis that GMF reversal contributes to inducing changes in plant development that might justify a higher selective pressure, eventually leading to plant evolution. PMID:26649488

Is light-induced degradation of a-Si:H/c-Si interfaces reversible?

DOE Office of Scientific and Technical Information (OSTI.GOV)

El Mhamdi, El Mahdi; Holovsky, Jakub; Demaurex, Bénédicte

2014-06-23

Thin hydrogenated amorphous silicon (a-Si:H) films deposited on crystalline silicon (c-Si) surfaces are sensitive probes for the bulk electronic properties of a-Si:H. Here, we use such samples during repeated low-temperature annealing and visible-light soaking to investigate the long-term stability of a-Si:H films. We observe that during annealing the electronic improvement of the interfaces follows stretched exponentials as long as hydrogen evolution in the films can be detected. Once such evolution is no longer observed, the electronic improvement occurs much faster. Based on these findings, we discuss how the reversibility of light-induced defects depends on (the lack of observable) hydrogen evolution.

Exploring the spiral of silence in adjustable social networks

NASA Astrophysics Data System (ADS)

Wu, Yue; Du, Ya-Jun; Li, Xian-Yong; Chen, Xiao-Liang

2015-03-01

This study extends the understanding of the spiral of silence theory by taking into account four factors, including the topology of networks, the time factor of information transmission, the node degree of individuals and the freedom of expression. Simulation experiments analyze the silencers, public opinion in steady state and relaxation time in small-world networks, scale-free networks and community-structured networks by adjusting the initial conditions. Results highlight that individuals are easier to keep silent in scale-free network, especially when the individual with big degree and minority opinion starts the discussion. Conversely, there are only a few individuals keep silent in the community-structured network when the two communities hold opposite opinions. Moreover, the number of silencers grows as the degree of coupling increases, and it decreases as the freedom of expression goes up. By analyzing the public opinion evolution, we also find some important conditions, such as the network topology, the potential public opinion distribution, and the status and sides of the first speaker, can drive the minority reversal.

Current profile redistribution driven by neutral beam injection in a reversed-field pinch

NASA Astrophysics Data System (ADS)

Parke, E.; Anderson, J. K.; Brower, D. L.; Den Hartog, D. J.; Ding, W. X.; Johnson, C. A.; Lin, L.

2016-05-01

Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm with neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q0 by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].

Microturbulence studies of pulsed poloidal current drive discharges in the reversed field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carmody, D., E-mail: dcarmody@wisc.edu; Pueschel, M. J.; Anderson, J. K.

2015-01-15

Experimental discharges with pulsed poloidal current drive (PPCD) in the Madison Symmetric Torus reversed field pinch are investigated using a semi-analytic equilibrium model in the gyrokinetic turbulence code GENE. PPCD cases, with plasma currents of 500 kA and 200 kA, exhibit a density-gradient-driven trapped electron mode (TEM) and an ion temperature gradient mode, respectively. Relative to expectations of tokamak core plasmas, the critical gradients for the onset of these instabilities are found to be greater by roughly a factor of the aspect ratio. A significant upshift in the nonlinear TEM transport threshold, previously found for tokamaks, is confirmed in nonlinear reversed fieldmore » pinch simulations and is roughly three times the threshold for linear instability. The simulated heat fluxes can be brought in agreement with measured diffusivities by introducing a small, resonant magnetic perturbation, thus modeling the residual fluctuations from tearing modes. These fluctuations significantly enhance transport.« less

Studies on the Effects of High Renewable Penetrations on Driving Point Impedance and Voltage Regulator Performance: National Renewable Energy Laboratory/Sacramento Municipal Utility District Load Tap Changer Driving Point Impedance Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagarajan, Adarsh; Coddington, Michael H.; Brown, David

Voltage regulators perform as desired when regulating from the source to the load and when regulating from a strong source (utility) to a weak source (distributed generation). (See the glossary for definitions of a strong source and weak source.) Even when the control is provisioned for reverse operation, it has been observed that tap-changing voltage regulators do not perform as desired in reverse when attempting regulation from the weak source to the strong source. The region of performance that is not as well understood is the regulation between sources that are approaching equal strength. As part of this study, wemore » explored all three scenarios: regulator control from a strong source to a weak source (classic case), control from a weak source to a strong source (during reverse power flow), and control between equivalent sources.« less

Evolution of dispersal and life history interact to drive accelerating spread of an invasive species.

PubMed

Perkins, T Alex; Phillips, Benjamin L; Baskett, Marissa L; Hastings, Alan

2013-08-01

Populations on the edge of an expanding range are subject to unique evolutionary pressures acting on their life-history and dispersal traits. Empirical evidence and theory suggest that traits there can evolve rapidly enough to interact with ecological dynamics, potentially giving rise to accelerating spread. Nevertheless, which of several evolutionary mechanisms drive this interaction between evolution and spread remains an open question. We propose an integrated theoretical framework for partitioning the contributions of different evolutionary mechanisms to accelerating spread, and we apply this model to invasive cane toads in northern Australia. In doing so, we identify a previously unrecognised evolutionary process that involves an interaction between life-history and dispersal evolution during range shift. In roughly equal parts, life-history evolution, dispersal evolution and their interaction led to a doubling of distance spread by cane toads in our model, highlighting the potential importance of multiple evolutionary processes in the dynamics of range expansion. © 2013 John Wiley & Sons Ltd/CNRS.

Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup.

PubMed

Beck, Emily A; Llopart, Ana

2015-11-25

Rapid evolution of centromeric satellite repeats is thought to cause compensatory amino acid evolution in interacting centromere-associated kinetochore proteins. Cid, a protein that mediates kinetochore/centromere interactions, displays particularly high amino acid turnover. Rapid evolution of both Cid and centromeric satellite repeats led us to hypothesize that the apparent compensatory evolution may extend to interacting partners in the Condensin I complex (i.e., SMC2, SMC4, Cap-H, Cap-D2, and Cap-G) and HP1s. Missense mutations in these proteins often result in improper centromere formation and aberrant chromosome segregation, thus selection for maintained function and coevolution among proteins of the complex is likely strong. Here, we report evidence of rapid evolution and recurrent positive selection in seven centromere-associated proteins in species of the Drosophila melanogaster subgroup, and further postulate that positive selection on these proteins could be a result of centromere drive and compensatory changes, with kinetochore proteins competing for optimal spindle attachment.

A single evolutionary innovation drives the deep evolution of symbiotic N2-fixation in angiosperms

PubMed Central

Werner, Gijsbert D. A.; Cornwell, William K.; Sprent, Janet I.; Kattge, Jens; Kiers, E. Toby

2014-01-01

Symbiotic associations occur in every habitat on earth, but we know very little about their evolutionary histories. Current models of trait evolution cannot adequately reconstruct the deep history of symbiotic innovation, because they assume homogenous evolutionary processes across millions of years. Here we use a recently developed, heterogeneous and quantitative phylogenetic framework to study the origin of the symbiosis between angiosperms and nitrogen-fixing (N2) bacterial symbionts housed in nodules. We compile the largest database of global nodulating plant species and reconstruct the symbiosis’ evolution. We identify a single, cryptic evolutionary innovation driving symbiotic N2-fixation evolution, followed by multiple gains and losses of the symbiosis, and the subsequent emergence of ‘stable fixers’ (clades extremely unlikely to lose the symbiosis). Originating over 100 MYA, this innovation suggests deep homology in symbiotic N2-fixation. Identifying cryptic innovations on the tree of life is key to understanding the evolution of complex traits, including symbiotic partnerships. PMID:24912610

Anthropogenic fire drives the evolution of seed traits

PubMed Central

Gómez-González, Susana; Torres-Díaz, Cristian; Bustos-Schindler, Carlos; Gianoli, Ernesto

2011-01-01

Fire is a major disturbance affecting ecosystems worldwide. Phylogenetic studies have shown that the evolution of seed persistence (fire resistance) is associated with fire frequency or severity. However, the existence of specific seed traits resulting from natural selection mediated by fire remains a key question in plant evolution. We evaluated the role of fire in the evolution of seed traits from a microevolutionary perspective, using as a study system a native forb from the Chilean matorral, where fire is a novel, anthropogenic disturbance. We show that anthropogenic fires are shaping the evolution of seed traits such as pubescence and shape. Among-population variation in seed pubescence, shape, and pericarp thickness was strongly associated with fire frequency, and within a population, fire selected those plants with more pubescent seeds, thicker pericarps, and less rounded seeds. Seed pubescence and shape were shown to be heritable traits. Our findings provide insights into the understanding of the evolution of seed traits in fire-prone environments and demonstrate that human-made fires can be driving evolutionary changes in plant species from ecosystems where fires do not occur naturally. PMID:22065739

Anthropogenic fire drives the evolution of seed traits.

PubMed

Gómez-González, Susana; Torres-Díaz, Cristian; Bustos-Schindler, Carlos; Gianoli, Ernesto

2011-11-15

Fire is a major disturbance affecting ecosystems worldwide. Phylogenetic studies have shown that the evolution of seed persistence (fire resistance) is associated with fire frequency or severity. However, the existence of specific seed traits resulting from natural selection mediated by fire remains a key question in plant evolution. We evaluated the role of fire in the evolution of seed traits from a microevolutionary perspective, using as a study system a native forb from the Chilean matorral, where fire is a novel, anthropogenic disturbance. We show that anthropogenic fires are shaping the evolution of seed traits such as pubescence and shape. Among-population variation in seed pubescence, shape, and pericarp thickness was strongly associated with fire frequency, and within a population, fire selected those plants with more pubescent seeds, thicker pericarps, and less rounded seeds. Seed pubescence and shape were shown to be heritable traits. Our findings provide insights into the understanding of the evolution of seed traits in fire-prone environments and demonstrate that human-made fires can be driving evolutionary changes in plant species from ecosystems where fires do not occur naturally.

Coping with Uncertainty: Woodpecker Finches (Cactospiza pallida) from an Unpredictable Habitat Are More Flexible than Birds from a Stable Habitat

PubMed Central

Tebbich, Sabine; Teschke, Irmgard

2014-01-01

Behavioural flexibility is thought to be a major factor in evolution. It may facilitate the discovery and exploitation of new resources, which in turn may expose populations to novel selective forces and facilitate adaptive radiation. Darwin's finches are a textbook example of adaptive radiation. They are fast learners and show a range of unusual foraging techniques, probably as a result of their flexibility. In this study we aimed to test whether variability of the environment is correlated with flexibility. We compared woodpecker finches from a dry area (hereafter, Arid Zone), where food availability is variable, with individuals from a cloud forest (hereafter, Scalesia zone) where food abundance is stable. As parameters for flexibility, we measured neophilia and neophobia, which are two aspects of reaction to novelty, reversal learning and problem-solving. We found no differences in performance on a problem-solving task but, in line with our prediction, individuals from the Arid Zone were significantly faster reversal learners and more neophilic than their conspecifics from the Scalesia zone. The latter result supports the notion that environmental variability drives flexibility. In contrast to our prediction, Arid Zone birds were even more neophobic than birds from the Scalesia Zone. The latter result could be the consequence of differences in predation pressure between the two vegetation zones. PMID:24638107

Matrix quality and disturbance frequency drive evolution of species behavior at habitat boundaries.

PubMed

Martin, Amanda E; Fahrig, Lenore

2015-12-01

Previous theoretical studies suggest that a species' landscape should influence the evolution of its dispersal characteristics, because landscape structure affects the costs and benefits of dispersal. However, these studies have not considered the evolution of boundary crossing, that is, the tendency of animals to cross from habitat to nonhabitat ("matrix"). It is important to understand this dispersal behavior, because of its effects on the probability of population persistence. Boundary-crossing behavior drives the rate of interaction with matrix, and thus, it influences the rate of movement among populations and the risk of dispersal mortality. We used an individual-based, spatially explicit model to simulate the evolution of boundary crossing in response to landscape structure. Our simulations predict higher evolved probabilities of boundary crossing in landscapes with more habitat, less fragmented habitat, higher-quality matrix, and more frequent disturbances (i.e., fewer generations between local population extinction events). Unexpectedly, our simulations also suggest that matrix quality and disturbance frequency have much stronger effects on the evolution of boundary crossing than either habitat amount or habitat fragmentation. Our results suggest that boundary-crossing responses are most affected by the costs of dispersal through matrix and the benefits of escaping local extinction events. Evolution of optimal behavior at habitat boundaries in response to the landscape may have implications for species in human-altered landscapes, because this behavior may become suboptimal if the landscape changes faster than the species' evolutionary response to that change. Understanding how matrix quality and habitat disturbance drive evolution of behavior at boundaries, and how this in turn influences the extinction risk of species in human-altered landscapes should help us identify species of conservation concern and target them for management.

AST: Activity-Security-Trust driven modeling of time varying networks

PubMed Central

Wang, Jian; Xu, Jiake; Liu, Yanheng; Deng, Weiwen

2016-01-01

Network modeling is a flexible mathematical structure that enables to identify statistical regularities and structural principles hidden in complex systems. The majority of recent driving forces in modeling complex networks are originated from activity, in which an activity potential of a time invariant function is introduced to identify agents’ interactions and to construct an activity-driven model. However, the new-emerging network evolutions are already deeply coupled with not only the explicit factors (e.g. activity) but also the implicit considerations (e.g. security and trust), so more intrinsic driving forces behind should be integrated into the modeling of time varying networks. The agents undoubtedly seek to build a time-dependent trade-off among activity, security, and trust in generating a new connection to another. Thus, we reasonably propose the Activity-Security-Trust (AST) driven model through synthetically considering the explicit and implicit driving forces (e.g. activity, security, and trust) underlying the decision process. AST-driven model facilitates to more accurately capture highly dynamical network behaviors and figure out the complex evolution process, allowing a profound understanding of the effects of security and trust in driving network evolution, and improving the biases induced by only involving activity representations in analyzing the dynamical processes. PMID:26888717

Phase space holes and synchronized BGK modes in autoresonantly driven, Penning-trapped electron clouds

NASA Astrophysics Data System (ADS)

Friedland, Lazar; Fajans, Joel; Bertsche, Will; Wurtele, Jonathan

2003-10-01

We study excitation and control of BGK modes in pure electron plasmas in a Penning trap. We apply an oscillating external potential with a negatively chirped frequency. This drive resonates with, and phase-locks to, a group of axially bouncing electrons in the trap. All initially phase-locked electrons remain phase-locked during the chirp (the autoresonance phenomenon), while some new particles are added to the resonant group, as the bucket moves through the phase space. This creates an oscillating in space and slowly evolving in energy hole in the phase space distribution of the electrons. The electron density perturbation associated with this evolving hole yields a BGK mode synchronized with the drive. The local depth of the hole in phase space, and, thus, the amplitude of the mode are controlled by the external parameter (the driving frequency). The process is reversible, so that the BGK mode can be returned to its nearly initial state, by reversing the direction of variation of the driving frequency. A kinetic theory of this excitation process is developed. The theory uses results on passage through, and capture into, bounce resonance in the system from Monte Carlo simulations of resonant bucket dynamics. We discuss the dependence of the excited BGK mode on the drive frequency chirp rate and other plasma parameters and compare these predictions with experiments.

Quantifying irreversible movement in steep, fractured bedrock permafrost on Matterhorn (CH)

NASA Astrophysics Data System (ADS)

Weber, Samuel; Beutel, Jan; Faillettaz, Jérome; Hasler, Andreas; Krautblatter, Michael; Vieli, Andreas

2017-02-01

Understanding rock slope kinematics in steep, fractured bedrock permafrost is a challenging task. Recent laboratory studies have provided enhanced understanding of rock fatigue and fracturing in cold environments but were not successfully confirmed by field studies. This study presents a unique time series of fracture kinematics, rock temperatures and environmental conditions at 3500 m a. s. l. on the steep, strongly fractured Hörnligrat of the Matterhorn (Swiss Alps). Thanks to 8 years of continuous data, the longer-term evolution of fracture kinematics in permafrost can be analyzed with an unprecedented level of detail. Evidence for common trends in spatiotemporal pattern of fracture kinematics could be found: a partly reversible seasonal movement can be observed at all locations, with variable amplitudes. In the wider context of rock slope stability assessment, we propose separating reversible (elastic) components of fracture kinematics, caused by thermoelastic strains, from the irreversible (plastic) component due to other processes. A regression analysis between temperature and fracture displacement shows that all instrumented fractures exhibit reversible displacements that dominate fracture kinematics in winter. Furthermore, removing this reversible component from the observed displacement enables us to quantify the irreversible component. From this, a new metric - termed index of irreversibility - is proposed to quantify relative irreversibility of fracture kinematics. This new index can identify periods when fracture displacements are dominated by irreversible processes. For many sensors, irreversible enhanced fracture displacement is observed in summer and its initiation coincides with the onset of positive rock temperatures. This likely indicates thawing-related processes, such as meltwater percolation into fractures, as a forcing mechanism for irreversible displacements. For a few instrumented fractures, irreversible displacements were found at the onset of the freezing period, suggesting that cryogenic processes act as a driving factor through increasing ice pressure. The proposed analysis provides a tool for investigating and better understanding processes related to irreversible kinematics.

Coevolution of landesque capital intensive agriculture and sociopolitical hierarchy.

PubMed

Sheehan, Oliver; Watts, Joseph; Gray, Russell D; Atkinson, Quentin D

2018-04-03

One of the defining trends of the Holocene has been the emergence of complex societies. Two essential features of complex societies are intensive resource use and sociopolitical hierarchy. Although it is widely agreed that these two phenomena are associated cross-culturally and have both contributed to the rise of complex societies, the causality underlying their relationship has been the subject of longstanding debate. Materialist theories of cultural evolution tend to view resource intensification as driving the development of hierarchy, but the reverse order of causation has also been advocated, along with a range of intermediate views. Phylogenetic methods have the potential to test between these different causal models. Here we report the results of a phylogenetic study that modeled the coevolution of one type of resource intensification-the development of landesque capital intensive agriculture-with political complexity and social stratification in a sample of 155 Austronesian-speaking societies. We found support for the coevolution of landesque capital with both political complexity and social stratification, but the contingent and nondeterministic nature of both of these relationships was clear. There was no indication that intensification was the "prime mover" in either relationship. Instead, the relationship between intensification and social stratification was broadly reciprocal, whereas political complexity was more of a driver than a result of intensification. These results challenge the materialist view and emphasize the importance of both material and social factors in the evolution of complex societies, as well as the complex and multifactorial nature of cultural evolution. Copyright © 2018 the Author(s). Published by PNAS.

Postmating-prezygotic isolation is not an important source of selection for reinforcement within and between species in Drosophila pseudoobscura and D. persimilis.

PubMed

Lorch, Patrick D; Servedio, Maria R

2005-05-01

Most work on adaptive speciation to date has focused on the role of low hybrid fitness as the force driving reinforcement (the evolution of premating isolation after secondary contact that reduces the likelihood of matings between populations). However, recent theoretical work has shown that postmating, prezygotic incompatibilities may also be important in driving premating isolation. We quantified premating, postmating-prezygotic, and early postzygotic fitness effects in crosses among three populations: Drosophila persimilis, D. pseudoobscura USA (sympatric to D. persimilis), and D. pseudoobscura Bogotá (allopatric to D. persimilis). Interspecific matings were more likely to fail when they involved the sympatric populations than when they involved the allopatric populations, consistent with reinforcement. We also found that failure rate in sympatric mating trials depended on whether D. persimilis females were paired with D. pseudoobscura males or the reverse. This asymmetry most likely indicates differences in discrimination against heterospecific males by females. By measuring egg laying rate, fertilization success and hatching success, we also compared components of postmating-prezygotic and early postzygotic isolation. Postmating-prezygotic fitness costs were small and not distinguishable between hetero- and conspecific crosses. Early postzygotic fitness effects due to hatching success differences were also small in between-population crosses. There was, however, a postzygotic fitness effect that may have resulted from an X-linked allele found in one of the two strains of D. pseudoobscura USA. We conclude that the postmating-prezygotic fitness costs we measured probably did not drive premating isolation in these species. Premating isolation is most likely driven in sympatric populations by previously known hybrid male sterility.

Aksu-Dinar Fault System: Its bearing on the evolution of the Isparta Angle (SW Turkey)

NASA Astrophysics Data System (ADS)

Kaymakci, Nuretdin; Özacar, Arda; Langereis, Cornelis G.; Özkaptan, Murat; Gülyüz, Erhan; van Hinsbergen, Douwe J. J.; Uzel, Bora; McPhee, Peter; Sözbilir, Hasan

2017-04-01

The Isparta Angle is a triangular structure in SW Turkey with NE-SW trending western and NW-SE trending eastern flanks. Aksu Fault is located within the core of this structure and have been taken-up large E-W shortening and sinistral translation since the Late Miocene. It is an inherited structure which emplaced Antalya nappes over the Beydaǧları Platform during the late Eocene to Late Miocene and was reactivated by the Pliocene as a high angle reverse fault to accommodate the counter-clockwise rotation of Beydaǧları and SW Anatolia. On the other hand, the Dinar Fault is a normal fault with slight sinistral component has been active since Pliocene. These two structures are collinear and delimit areas with clockwise and counter-clockwise rotations. The areas to the north and east of these structures rotated clockwise while southern and western areas are rotated counter-clockwise. We claim that the Dinar-Aksu Fault System facilitate rotational deformation in the region as a scissor like mechanism about a pivot point north of Burdur. This mechanism resulted in the normal motion along the Dinar and reverse motion along the Aksu faults with combined sinistral translation component on both structures. We claim that the driving force for the motion of these faults and counter-clockwise rotation of the SW Anatolia seems to be slab-pull forces exerted by the east dipping Antalya Slab, a relic of Tethys oceanic lithosphere. The research for this paper is supported by TUBITAK - Grant Number 111Y239. Key words: Dinar Fault, Aksu Fault, Isparta Angle, SW Turkey, Burdur Pivot, Normal Fault, Reverse Fault

Reverse Flow Engine Core Having a Ducted Fan with Integrated Secondary Flow Blades

NASA Technical Reports Server (NTRS)

Kisska, Michael K. (Inventor); Princen, Norman H. (Inventor); Kuehn, Mark S. (Inventor); Cosentino, Gary B. (Inventor)

2014-01-01

Secondary air flow is provided for a ducted fan having a reverse flow turbine engine core driving a fan blisk. The fan blisk incorporates a set of thrust fan blades extending from an outer hub and a set of integral secondary flow blades extending intermediate an inner hub and the outer hub. A nacelle provides an outer flow duct for the thrust fan blades and a secondary flow duct carries flow from the integral secondary flow blades as cooling air for components of the reverse flow turbine engine.

The concurrent evolution of cooperation and the population structures that support it.

PubMed

Powers, Simon T; Penn, Alexandra S; Watson, Richard A

2011-06-01

The evolution of cooperation often depends upon population structure, yet nearly all models of cooperation implicitly assume that this structure remains static. This is a simplifying assumption, because most organisms possess genetic traits that affect their population structure to some degree. These traits, such as a group size preference, affect the relatedness of interacting individuals and hence the opportunity for kin or group selection. We argue that models that do not explicitly consider their evolution cannot provide a satisfactory account of the origin of cooperation, because they cannot explain how the prerequisite population structures arise. Here, we consider the concurrent evolution of genetic traits that affect population structure, with those that affect social behavior. We show that not only does population structure drive social evolution, as in previous models, but that the opportunity for cooperation can in turn drive the creation of population structures that support it. This occurs through the generation of linkage disequilibrium between socio-behavioral and population-structuring traits, such that direct kin selection on social behavior creates indirect selection pressure on population structure. We illustrate our argument with a model of the concurrent evolution of group size preference and social behavior. © 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.

28. MESTA STEAM ENGINE, INSTALLED BY THE CORRIGAN, McKINNEY COMPANY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. MESTA STEAM ENGINE, INSTALLED BY THE CORRIGAN, McKINNEY COMPANY IN 1916, STILL DRIVES THE 44-INCH REVERSING BLOOMING MILL. THE TWIN TANDAM, COMPOUND CONDENSING, REVERSING STEAM ENGINE HAS A RATED CAPACITY OF 35,000 H.P. IT WAS BUILT BY THE MESTA MACHINE COMPANY OF PITTSBURGH. - Corrigan, McKinney Steel Company, 3100 East Forty-fifth Street, Cleveland, Cuyahoga County, OH

Convergence of biannual moulting strategies across birds and mammals

PubMed Central

Burns, Jennifer M.; Breed, Greg A.

2018-01-01

Birds and mammals have developed numerous strategies for replacing worn feathers and hair. Moulting usually occurs on an annual basis; however, moults that take place twice per year (biannual moults) also occur. Here, we review the forces driving the evolution of various moult strategies, focusing on the special case of the complete biannual moult as a convergence of selection pressures across birds and mammals. Current evidence suggests that harsh environmental conditions or seasonality (e.g. larger variation in temperatures) drive evolution of a biannual moult. In turn, the biannual moult can respond to secondary selection that results in phenotypic alteration such as colour changes for mate choice dynamics (sexual selection) or camouflage requirements (natural selection). We discuss the contributions of natural and sexual selection to the evolution of biannual moulting strategies in the contexts of energetics, niche selection, functionality and physiological mechanisms. Finally, we suggest that moult strategies are directly related to species niche because environmental attributes drive the utility (e.g. thermoregulation, camouflage, social dynamics) of the hair or feathers. Functional efficiency of moult may be undermined if the pace of evolution fails to match that of the changing climate. Thus, future research should seek to understand the plasticity of moult duration and phenology, especially in the context of annual cycles. PMID:29769361

Self-consistent modeling of the dynamic evolution of magnetic island growth in the presence of stabilizing electron-cyclotron current drive

NASA Astrophysics Data System (ADS)

Chatziantonaki, Ioanna; Tsironis, Christos; Isliker, Heinz; Vlahos, Loukas

2013-11-01

The most promising technique for the control of neoclassical tearing modes in tokamak experiments is the compensation of the missing bootstrap current with an electron-cyclotron current drive (ECCD). In this frame, the dynamics of magnetic islands has been studied extensively in terms of the modified Rutherford equation (MRE), including the presence of a current drive, either analytically described or computed by numerical methods. In this article, a self-consistent model for the dynamic evolution of the magnetic island and the driven current is derived, which takes into account the island's magnetic topology and its effect on the current drive. The model combines the MRE with a ray-tracing approach to electron-cyclotron wave-propagation and absorption. Numerical results exhibit a decrease in the time required for complete stabilization with respect to the conventional computation (not taking into account the island geometry), which increases by increasing the initial island size and radial misalignment of the deposition.

Dead Element Replicating: Degenerate R2 Element Replication and rDNA Genomic Turnover in the Bacillus rossius Stick Insect (Insecta: Phasmida)

PubMed Central

Martoni, Francesco; Eickbush, Danna G.; Scavariello, Claudia; Luchetti, Andrea; Mantovani, Barbara

2015-01-01

R2 is an extensively investigated non-LTR retrotransposon that specifically inserts into the 28S rRNA gene sequences of a wide range of metazoans, disrupting its functionality. During R2 integration, first strand synthesis can be incomplete so that 5’ end deleted copies are occasionally inserted. While active R2 copies repopulate the locus by retrotransposing, the non-functional truncated elements should frequently be eliminated by molecular drive processes leading to the concerted evolution of the rDNA array(s). Although, multiple R2 lineages have been discovered in the genome of many animals, the rDNA of the stick insect Bacillus rossius exhibits a peculiar situation: it harbors both a canonical, functional R2 element (R2Brfun) as well as a full-length but degenerate element (R2Brdeg). An intensive sequencing survey in the present study reveals that all truncated variants in stick insects are present in multiple copies suggesting they were duplicated by unequal recombination. Sequencing results also demonstrate that all R2Brdeg copies are full-length, i. e. they have no associated 5' end deletions, and functional assays indicate they have lost the active ribozyme necessary for R2 RNA maturation. Although it cannot be completely ruled out, it seems unlikely that the degenerate elements replicate via reverse transcription, exploiting the R2Brfun element enzymatic machinery, but rather via genomic amplification of inserted 28S by unequal recombination. That inactive copies (both R2Brdeg or 5'-truncated elements) are not eliminated in a short term in stick insects contrasts with findings for the Drosophila R2, suggesting a widely different management of rDNA loci and a lower efficiency of the molecular drive while achieving the concerted evolution. PMID:25799008

Iron Speciation in Minerals and Melts at High Pressure: Implications for the Redox Evolution of the Early Mantle

NASA Astrophysics Data System (ADS)

Armstrong, K.; Frost, D. J.; McCammon, C. A.; Rubie, D. C.; Boffa Ballaran, T.; Miyajima, N.

2016-12-01

During the differentiation of the early Earth, the silicates of the mantle must have been in equilibrium with core-forming metal iron, as indicated by the depletion of siderophile elements from the mantle. Studies of ancient rocks suggest that by at least 3.9 Ga, the upper mantle was 4-5 log units more oxidized than metal saturation implies (Delano 2001). The process(es) by which the mantle was oxidized is unclear, but has implications for the timing of accretion, differentiation, and volatile delivery to the early Earth, as well as evolution of the early atmosphere. One plausible oxidation mechanism is suggested by the tendency of high-pressure silicate minerals to favor Fe3+ over Fe2+ in their structures, even at metal saturation. This preference in the lower mantle mineral bridgmanite has been proposed to drive the disproportionation reaction of FeO to form Fe­2O3 and iron metal (Frost and McCammon 2008). We have performed experiments at the Ru-RuO2 fO2 buffer which show that silicate melts may mirror this behavior and Fe3+ may be stabilized with pressure for a constant fO2; by 21 GPa, the previously observed trend of Fe3+ decreasing with pressure (O'Neill, 2006) reverses and ferric iron content had increased. If this is also the case at lower oxygen fugacities, FeO disproportionation may have occurred at the base of an early magma ocean, establishing a redox gradient similar to what is presumed for the mantle today. Here we report results of further multianvil and diamond anvil cell experiments exploring the plausibility of FeO disproportionation driving mantle oxidation. Experiments investigating Fe speciation in high pressure melts at variable fO2 will be discussed along with results of diamond anvil cell experiments investigating ferric iron content of lower mantle minerals at metal saturation.

Modeling the Evolution of Female Meiotic Drive in Maize

PubMed Central

Hall, David W.; Dawe, R. Kelly

2017-01-01

Autosomal drivers violate Mendel’s law of segregation in that they are overrepresented in gametes of heterozygous parents. For drivers to be polymorphic within populations rather than fixing, their transmission advantage must be offset by deleterious effects on other fitness components. In this paper, we develop an analytical model for the evolution of autosomal drivers that is motivated by the neocentromere drive system found in maize. In particular, we model both the transmission advantage and deleterious fitness effects on seed viability, pollen viability, seed to adult survival mediated by maternal genotype, and seed to adult survival mediated by offspring genotype. We derive general, biologically intuitive conditions for the four most likely evolutionary outcomes and discuss the expected evolution of autosomal drivers given these conditions. Finally, we determine the expected equilibrium allele frequencies predicted by the model given recent estimates of fitness components for all relevant genotypes and show that the predicted equilibrium is within the range observed in maize land races for levels of drive at the low end of what has been observed. PMID:29122849

Effect of Temperature Reversion on Hot Ductility and Flow Stress-Strain Curves of C-Mn Continuously Cast Steels

NASA Astrophysics Data System (ADS)

Dong, Zhihua; Li, Wei; Long, Mujun; Gui, Lintao; Chen, Dengfu; Huang, Yunwei; Vitos, Levente

2015-08-01

The influence of temperature reversion in secondary cooling and its reversion rate on hot ductility and flow stress-strain curve of C-Mn steel has been investigated. Tensile specimens were cooled at various regimes. One cooling regime involved cooling at a constant rate of 100 °C min-1 to the test temperature, while the others involved temperature reversion processes at three different reversion rates before deformation. After hot tensile test, the evolution of mechanical properties of steel was analyzed at various scales by means of microstructure observation, ab initio prediction, and thermodynamic calculation. Results indicated that the temperature reversion in secondary cooling led to hot ductility trough occurring at higher temperature with greater depth. With increasing temperature reversion rate, the low temperature end of ductility trough extended toward lower temperature, leading to wider hot ductility trough with slightly reducing depth. Microstructure examinations indicated that the intergranular fracture related to the thin film-like ferrite and (Fe,Mn)S particles did not changed with varying cooling regimes; however, the Widmanstatten ferrite surrounding austenite grains resulted from the temperature reversion process seriously deteriorated the ductility. In addition, after the temperature reversion in secondary cooling, the peak stress on the flow curve slightly declined and the peak of strain to peak stress occurred at higher temperature. With increasing temperature reversion rate, the strain to peak stress slightly increased, while the peak stress showed little variation. The evolution of plastic modulus and strain to peak stress of austenite with varying temperature was in line with the theoretical prediction on Fe.

Large reversible magnetostrictive effect of MnCoSi-based compounds prepared by high-magnetic-field solidification

NASA Astrophysics Data System (ADS)

Hu, Q. B.; Hu, Y.; Zhang, S.; Tang, W.; He, X. J.; Li, Z.; Cao, Q. Q.; Wang, D. H.; Du, Y. W.

2018-01-01

The MnCoSi compound is a potential magnetostriction material since the magnetic field can drive a metamagnetic transition from an antiferromagnetic phase to a high magnetization phase in it, which accompanies a large lattice distortion. However, a large driving magnetic field, magnetic hysteresis, and poor mechanical properties seriously hinder its application for magnetostriction. By substituting Fe for Mn and introducing vacancies of the Mn element, textured and dense Mn0.97Fe0.03CoSi and Mn0.88CoSi compounds are prepared through a high-magnetic-field solidification approach. As a result, large room-temperature and reversible magnetostriction effects are observed in these compounds at a low magnetic field. The origin of this large magnetostriction effect and potential applications are discussed.

Speeding up adiabatic population transfer in a Josephson qutrit via counter-diabatic driving

NASA Astrophysics Data System (ADS)

Feng, Zhi-Bo; Lu, Xiao-Jing; Li, M.; Yan, Run-Ying; Zhou, Yun-Qing

2017-12-01

We propose a theoretical scheme to speed up adiabatic population transfer in a Josephson artificial qutrit by transitionless quantum driving. At a magic working point, an effective three-level subsystem can be chosen to constitute our qutrit. With Stokes and pump driving, adiabatic population transfer can be achieved in the qutrit by means of stimulated Raman adiabatic passage. Assisted by a counter-diabatic driving, the adiabatic population transfer can be sped up drastically with accessible parameters. Moreover, the accelerated operation is flexibly reversible and highly robust against decoherence effects. Thanks to these distinctive advantages, the present protocol could offer a promising avenue for optimal coherent operations in Josephson quantum circuits.

Reversibility and stability of information processing systems

NASA Technical Reports Server (NTRS)

Zurek, W. H.

1984-01-01

Classical and quantum models of dynamically reversible computers are considered. Instabilities in the evolution of the classical 'billiard ball computer' are analyzed and shown to result in a one-bit increase of entropy per step of computation. 'Quantum spin computers', on the other hand, are not only microscopically, but also operationally reversible. Readoff of the output of quantum computation is shown not to interfere with this reversibility. Dissipation, while avoidable in principle, can be used in practice along with redundancy to prevent errors.

Evolution of Muscle Activity Patterns Driving Motions of the Jaw and Hyoid during Chewing in Gnathostomes

PubMed Central

Konow, Nicolai; Herrel, Anthony; Ross, Callum F.; Williams, Susan H.; German, Rebecca Z.; Sanford, Christopher P. J.; Gintof, Chris

2011-01-01

Although chewing has been suggested to be a basal gnathostome trait retained in most major vertebrate lineages, it has not been studied broadly and comparatively across vertebrates. To redress this imbalance, we recorded EMG from muscles powering anteroposterior movement of the hyoid, and dorsoventral movement of the mandibular jaw during chewing. We compared muscle activity patterns (MAP) during chewing in jawed vertebrate taxa belonging to unrelated groups of basal bony fishes and artiodactyl mammals. Our aim was to outline the evolution of coordination in MAP. Comparisons of activity in muscles of the jaw and hyoid that power chewing in closely related artiodactyls using cross-correlation analyses identified reorganizations of jaw and hyoid MAP between herbivores and omnivores. EMG data from basal bony fishes revealed a tighter coordination of jaw and hyoid MAP during chewing than seen in artiodactyls. Across this broad phylogenetic range, there have been major structural reorganizations, including a reduction of the bony hyoid suspension, which is robust in fishes, to the acquisition in a mammalian ancestor of a muscle sling suspending the hyoid. These changes appear to be reflected in a shift in chewing MAP that occurred in an unidentified anamniote stem-lineage. This shift matches observations that, when compared with fishes, the pattern of hyoid motion in tetrapods is reversed and also time-shifted relative to the pattern of jaw movement. PMID:21705368

On a quantum mechanical system theory of the origin of life: from the Stapp-model to the origin of natural symbols

NASA Astrophysics Data System (ADS)

Balázs, András

2016-01-01

The Heisenberg-James-Stapp (quantum mechanical) mind model is surveyed and criticized briefly. The criticism points out that the model, while being essentially consistent concerning (human) consciousness, fundamentally lacks the evolutional point of view both onto- and phylogenetically. Ethology and other than Jamesian psychology is quoted and a quantum mechanical theoretical scheme is suggested to essentially extend Stapp's frame in an evolutionary context. It is proposed that its central supposition, spontaneous quantum measurement can be better utilized in an investigation of the origin of the "subjective" process, having come about concomitantly with the chemistry of the origin of life. We dwell on its applicability at this latter process, at its heart standing, it is supposed, the endophysical nonlinear "self-measurement" of (quantum mechanically describable) matter, and so our investigation is extended to this primeval phenomenon. It is suggested that the life phenomenon is an indirect C* → (W*) → C* quantum algebraic process transition, where the (W*) system would represent the living state. Summarized also are our previous results on an internalized, "reversed", time process, introduced originally by Gunji, which is subordinated to the external "forwards" time evolution, driving towards symmetry by gradual space-mappings, where the original splitting-up must have come about in a spontaneous symmetry breaking nonlinear "self-measurement" of matter in an endophysical World.

Spurious-Mode Control of Same-Phase Drive-Type Ultrasonic Motor

NASA Astrophysics Data System (ADS)

Aoyagi, Manabu; Watanabe, Hiroyuki; Tomikawa, Yoshiro; Takano, Takehiro

2002-05-01

A same-phase drive-type ultrasonic motor requires a single power source for its operation. In particular, self-oscillation driving is useful for driving a small ultrasonic motor. This type of ultrasonic motor has a spurious mode close to the operation frequency on its stator vibrator. The spurious vibration mode affects the oscillation frequency of a self-oscillation drive circuit. Hence the spurious vibration mode should be restrained or moved away from the neighborhood of the operation frequency. In this paper, we report that an inductor connected at an electrical control terminal provided on standby electrodes for the reverse rotation operation controls only the spurious vibration mode. The effect of an inductor connected at the control terminal was clarified by the simulation of an equivalent circuit and some experiments.

Dipole-quadrupole dynamics during magnetic field reversals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gissinger, Christophe

The shape and the dynamics of reversals of the magnetic field in a turbulent dynamo experiment are investigated. We report the evolution of the dipolar and the quadrupolar parts of the magnetic field in the VKS experiment, and show that the experimental results are in good agreement with the predictions of a recent model of reversals: when the dipole reverses, part of the magnetic energy is transferred to the quadrupole, reversals begin with a slow decay of the dipole and are followed by a fast recovery, together with an overshoot of the dipole. Random reversals are observed at the borderlinemore » between stationary and oscillatory dynamos.« less

Intrinsic subpicosecond magnetization reversal driven by femtosecond laser pulses in GdFeCo amorphous films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Shufa; Gao, Ruixin; Cheng, Chuyuan

2013-12-09

Ultrafast magnetization dynamics in GdFeCo films triggered by femtosecond laser pulses with and without an external field applied is studied experimentally for different excitation fluence. It is found that subpicosecond magnetization reversal occurs simultaneously in the ultrafast dynamics of both saturation and remnant magnetization states and almost identical within 13 ps, whereas relatively slow magnetization reversal across compensation point appears only in the dynamics of saturation magnetization state. It shows the subpicosecond magnetization reversal is external field independent, and originates from intrinsic magnetic evolution in ferrimagnetic system. The intrinsic subpicosecond reversal is qualitatively explained by linear reversal.

Density-dependent selection on mate search and evolution of Allee effects.

PubMed

Berec, Luděk; Kramer, Andrew M; Bernhauerová, Veronika; Drake, John M

2018-01-01

Sexually reproducing organisms require males and females to find each other. Increased difficulty of females finding mates as male density declines is the most frequently reported mechanism of Allee effects in animals. Evolving more effective mate search may alleviate Allee effects, but may depend on density regimes a population experiences. In particular, high-density populations may evolve mechanisms that induce Allee effects which become detrimental when populations are reduced and maintained at a low density. We develop an individual-based, eco-genetic model to study how mating systems and fitness trade-offs interact with changes in population density to drive evolution of the rate at which males or females search for mates. Finite mate search rate triggers Allee effects in our model and we explore how these Allee effects respond to such evolution. We allow a population to adapt to several population density regimes and examine whether high-density populations are likely to reverse adaptations attained at low densities. We find density-dependent selection in most of scenarios, leading to search rates that result in lower Allee thresholds in populations kept at lower densities. This mainly occurs when fecundity costs are imposed on mate search, and provides an explanation for why Allee effects are often observed in anthropogenically rare species. Optimizing selection, where the attained trait value minimizes the Allee threshold independent of population density, depended on the trade-off between search and survival, combined with monogamy when females were searching. Other scenarios led to runaway selection on the mate search rate, including evolutionary suicide. Trade-offs involved in mate search may thus be crucial to determining how density influences the evolution of Allee effects. Previous studies did not examine evolution of a trait related to the strength of Allee effects under density variation. We emphasize the crucial role that mating systems, fitness trade-offs and the evolving sex have in determining the density threshold for population persistence, in particular since evolution need not always take the Allee threshold to its minimum value. © 2017 The Authors. Journal of Animal Ecology © 2017 British Ecological Society.

Female penis, male vagina, and their correlated evolution in a cave insect.

PubMed

Yoshizawa, Kazunori; Ferreira, Rodrigo L; Kamimura, Yoshitaka; Lienhard, Charles

2014-05-05

Sex-specific elaborations are common in animals and have attracted the attention of many biologists, including Darwin [1]. It is accepted that sexual selection promotes the evolution of sex-specific elaborations. Due to the faster replenishment rate of gametes, males generally have higher potential reproductive and optimal mating rates than females. Therefore, sexual selection acts strongly on males [2], leading to the rapid evolution and diversification of male genitalia [3]. Male genitalia are sometimes used as devices for coercive holding of females as a result of sexual conflict over mating [4, 5]. In contrast, female genitalia are usually simple. Here we report the reversal of intromittent organs in the insect genus Neotrogla (Psocodea: Prionoglarididae) from Brazilian caves. Females have a highly elaborate, penis-like structure, the gynosome, while males lack an intromittent organ. The gynosome has species-specific elaborations, such as numerous spines that fit species-specific pouches in the simple male genital chamber. During prolonged copulation (~40-70 hr), a large and potentially nutritious ejaculate is transferred from the male via the gynosome. The correlated genital evolution in Neotrogla is probably driven by reversed sexual selection with females competing for seminal gifts. Nothing similar is known among sex-role reversed animals. Copyright © 2014 Elsevier Ltd. All rights reserved.

Lateral gene transfer in a heavy metal-contaminated-groundwater microbial community

DOE PAGES

Hemme, Christopher L.; Green, Stefan J.; Rishishwar, Lavanya; ...

2016-04-05

Here, unraveling the drivers controlling the response and adaptation of biological communities to environmental change, especially anthropogenic activities, is a central but poorly understood issue in ecology and evolution. Comparative genomics studies suggest that lateral gene transfer (LGT) is a major force driving microbial genome evolution, but its role in the evolution of microbial communities remains elusive.

Do arms races punctuate evolutionary stasis? Unified insights from phylogeny, phylogeography and microevolutionary processes.

PubMed

Toju, Hirokazu; Sota, Teiji

2009-09-01

One of the major controversies in evolutionary biology concerns the processes underlying macroevolutionary patterns in which prolonged stasis is disrupted by rapid, short-term evolution that leads species to new adaptive zones. Recent advances in the understanding of contemporary evolution have suggested that such rapid evolution can occur in the wild as a result of environmental changes. Here, we examined a novel hypothesis that evolutionary stasis is punctuated by co-evolutionary arms races, which continuously alter adaptive peaks and landscapes. Based on the phylogeny of long-mouthed weevils in the genus Curculio, likelihood ratio tests showed that the macroevolutionary pattern of the weevils coincides with the punctuational evolution model. A coalescent analysis of a species, Curculio camelliae, the mouthpart of which has diverged considerably among populations because of an arms race with its host plant, further suggested that major evolutionary shifts had occurred within 7000 generations. Through a microevolutionary analysis of the species, we also found that natural selection acting through co-evolutionary interactions is potentially strong enough to drive rapid evolutionary shifts between adaptive zones. Overall, we posit that co-evolution is an important factor driving the history of organismal evolution.

The early stages of duplicate gene evolution

PubMed Central

Moore, Richard C.; Purugganan, Michael D.

2003-01-01

Gene duplications are one of the primary driving forces in the evolution of genomes and genetic systems. Gene duplicates account for 8–20% of the genes in eukaryotic genomes, and the rates of gene duplication are estimated at between 0.2% and 2% per gene per million years. Duplicate genes are believed to be a major mechanism for the establishment of new gene functions and the generation of evolutionary novelty, yet very little is known about the early stages of the evolution of duplicated gene pairs. It is unclear, for example, to what extent selection, rather than neutral genetic drift, drives the fixation and early evolution of duplicate loci. Analysis of recently duplicated genes in the Arabidopsis thaliana genome reveals significantly reduced species-wide levels of nucleotide polymorphisms in the progenitor and/or duplicate gene copies, suggesting that selective sweeps accompany the initial stages of the evolution of these duplicated gene pairs. Our results support recent theoretical work that indicates that fates of duplicate gene pairs may be determined in the initial phases of duplicate gene evolution and that positive selection plays a prominent role in the evolutionary dynamics of the very early histories of duplicate nuclear genes. PMID:14671323

Microstructural Evolutions During Reversion Annealing of Cold-Rolled AISI 316 Austenitic Stainless Steel

NASA Astrophysics Data System (ADS)

Naghizadeh, Meysam; Mirzadeh, Hamed

2018-03-01

Microstructural evolutions during reversion annealing of a plastically deformed AISI 316 stainless steel were investigated and three distinct stages were identified: the reversion of strain-induced martensite to austenite, the primary recrystallization of the retained austenite, and the grain growth process. It was found that the slow kinetics of recrystallization at lower annealing temperatures inhibit the formation of an equiaxed microstructure and might effectively impair the usefulness of this thermomechanical treatment for the objective of grain refinement. By comparing the behavior of AISI 316 and 304 alloys, it was found that the mentioned slow kinetics is related to the retardation effect of solute Mo in the former alloy. At high reversion annealing temperature, however, an equiaxed austenitic microstructure was achieved quickly in AISI 316 stainless steel due to the temperature dependency of retardation effect of molybdenum, which allowed the process of recrystallization to happen easily. Conclusively, this work can shed some light on the issues of this efficient grain refining approach for microstructural control of austenitic stainless steels.

Microstructural Evolutions During Reversion Annealing of Cold-Rolled AISI 316 Austenitic Stainless Steel

NASA Astrophysics Data System (ADS)

Naghizadeh, Meysam; Mirzadeh, Hamed

2018-06-01

Microstructural evolutions during reversion annealing of a plastically deformed AISI 316 stainless steel were investigated and three distinct stages were identified: the reversion of strain-induced martensite to austenite, the primary recrystallization of the retained austenite, and the grain growth process. It was found that the slow kinetics of recrystallization at lower annealing temperatures inhibit the formation of an equiaxed microstructure and might effectively impair the usefulness of this thermomechanical treatment for the objective of grain refinement. By comparing the behavior of AISI 316 and 304 alloys, it was found that the mentioned slow kinetics is related to the retardation effect of solute Mo in the former alloy. At high reversion annealing temperature, however, an equiaxed austenitic microstructure was achieved quickly in AISI 316 stainless steel due to the temperature dependency of retardation effect of molybdenum, which allowed the process of recrystallization to happen easily. Conclusively, this work can shed some light on the issues of this efficient grain refining approach for microstructural control of austenitic stainless steels.

Modifications to the edge current profile with auxiliary edge current drive and improved confinement in a reversed-field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chapman, B.E.; Biewer, T.M.; Chattopadhyay, P.K.

2000-09-01

Auxiliary edge current drive is routinely applied in the Madison Symmetric Torus [R.N. Dexter, D. W. Kerst, T.W. Lovell et.al., Fusion Technol. 19, 131 (1991)] with the goal of modifying the parallel current profile to reduce current- driven magnetic fluctuations and the associated particle and energy transport. Provided by an inductive electric field, the current drive successfully reduces energy transport. First-time measurements of the modified edge current profile reveal that, relative to discharges without auxiliary current drive, the edge current density decreases. This decrease is explicable in terms of newly measured reductions in the dynamo (fluctuation-based) electric field and themore » electrical conductivity. Induced by the current drive, these two changes to the edge plasma play as much of a role in determining the resultant edge current profile as does the current drive itself.« less

The eco-evolutionary impacts of domestication and agricultural practices on wild species.

PubMed

Turcotte, Martin M; Araki, Hitoshi; Karp, Daniel S; Poveda, Katja; Whitehead, Susan R

2017-01-19

Agriculture is a dominant evolutionary force that drives the evolution of both domesticated and wild species. However, the various mechanisms of agriculture-induced evolution and their socio-ecological consequences are not often synthetically discussed. Here, we explore how agricultural practices and evolutionary changes in domesticated species cause evolution in wild species. We do so by examining three processes by which agriculture drives evolution. First, differences in the traits of domesticated species, compared with their wild ancestors, alter the selective environment and create opportunities for wild species to specialize. Second, selection caused by agricultural practices, including both those meant to maximize productivity and those meant to control pest species, can lead to pest adaptation. Third, agriculture can cause non-selective changes in patterns of gene flow in wild species. We review evidence for these processes and then discuss their ecological and sociological impacts. We finish by identifying important knowledge gaps and future directions related to the eco-evolutionary impacts of agriculture including their extent, how to prevent the detrimental evolution of wild species, and finally, how to use evolution to minimize the ecological impacts of agriculture.This article is part of the themed issue 'Human influences on evolution, and the ecological and societal consequences'. © 2016 The Author(s).

The eco-evolutionary impacts of domestication and agricultural practices on wild species

PubMed Central

Araki, Hitoshi; Karp, Daniel S.; Poveda, Katja

2017-01-01

Agriculture is a dominant evolutionary force that drives the evolution of both domesticated and wild species. However, the various mechanisms of agriculture-induced evolution and their socio-ecological consequences are not often synthetically discussed. Here, we explore how agricultural practices and evolutionary changes in domesticated species cause evolution in wild species. We do so by examining three processes by which agriculture drives evolution. First, differences in the traits of domesticated species, compared with their wild ancestors, alter the selective environment and create opportunities for wild species to specialize. Second, selection caused by agricultural practices, including both those meant to maximize productivity and those meant to control pest species, can lead to pest adaptation. Third, agriculture can cause non-selective changes in patterns of gene flow in wild species. We review evidence for these processes and then discuss their ecological and sociological impacts. We finish by identifying important knowledge gaps and future directions related to the eco-evolutionary impacts of agriculture including their extent, how to prevent the detrimental evolution of wild species, and finally, how to use evolution to minimize the ecological impacts of agriculture. This article is part of the themed issue ‘Human influences on evolution, and the ecological and societal consequences’. PMID:27920378

Punchets: nonlinear transport in Hamiltonian pump-ratchet hybrids

NASA Astrophysics Data System (ADS)

Dittrich, Thomas; Medina Sánchez, Nicolás

2018-02-01

‘Punchets’ are hybrids between ratchets and pumps, combining a spatially periodic static potential, typically asymmetric under space inversion, with a local driving that breaks time-reversal invariance, and are intended to model metal or semiconductor surfaces irradiated by a collimated laser beam. Their crucial feature is irregular driven scattering between asymptotic regions supporting periodic (as opposed to free) motion. With all binary spatio-temporal symmetries broken, scattering in punchets typically generates directed currents. We here study the underlying nonlinear transport mechanisms, from chaotic scattering to the parameter dependence of the currents, in three types of Hamiltonian models, (i) with spatially periodic potentials where only in the driven scattering region, spatial and temporal symmetries are broken, and (ii), spatially asymmetric (ratchet) potentials with a driving that only breaks time-reversal invariance. As more realistic models of laser-irradiated surfaces, we consider (iii), a driving in the form of a running wave confined to a compact region by a static envelope. In this case, the induced current can even run against the direction of wave propagation, drastically evidencing its nonlinear nature. Quantizing punchets is indicated as a viable research perspective.

Current profile redistribution driven by neutral beam injection in a reversed-field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parke, E.; Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706; Anderson, J. K.

2016-05-15

Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm withmore » neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q{sub 0} by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].« less

Improved transistorized AC motor controller for battery powered urban electric passenger vehicles

NASA Technical Reports Server (NTRS)

Peak, S. C.

1982-01-01

An ac motor controller for an induction motor electric vehicle drive system was designed, fabricated, tested, evaluated, and cost analyzed. A vehicle performance analysis was done to establish the vehicle tractive effort-speed requirements. These requirements were then converted into a set of ac motor and ac controller requirements. The power inverter is a three-phase bridge using power Darlington transistors. The induction motor was optimized for use with an inverter power source. The drive system has a constant torque output to base motor speed and a constant horsepower output to maximum speed. A gear shifting transmission is not required. The ac controller was scaled from the base 20 hp (41 hp peak) at 108 volts dec to an expanded horsepower and battery voltage range. Motor reversal was accomplished by electronic reversal of the inverter phase sequence. The ac controller can also be used as a boost chopper battery charger. The drive system was tested on a dynamometer and results are presented. The current-controlled pulse width modulation control scheme yielded improved motor current waveforms. The ac controller favors a higher system voltage.

Influence of Rainfall Product on Hydrological and Sediment Outputs when Calibrating the STREAP Rainfall Generator for the CAESAR-Lisflood Landscape Evolution Model

NASA Astrophysics Data System (ADS)

Skinner, Christopher; Peleg, Nadav; Quinn, Niall

2017-04-01

The use of Landscape Evolution Models often requires a timeseries of rainfall to drive the model. The spatial and temporal resolution of the driving data has an impact on several model outputs, including the shape of the landscape itself. Attempts to compensate for the spatiotemporal smoothing of local rainfall intensities are insufficient and may exacerbate these issues, meaning that to produce the best results the model needs to be run with data of highest spatial and temporal resolutions available. Some rainfall generators are able to produce timeseries with high spatial and temporal resolution. Observed data is used for the calibration of these generators. However, rainfall observations are highly uncertain and vary between different products (e.g. raingauges, weather radar) which may cascade through the Landscape Evolution Model. Here, we used the STREAP rainfall generator to produce high spatial (1km) and temporal (hourly) resolution ensembles of rainfall for a 50-year period, and used these to drive the CAESAR-Lisflood Landscape Evolution Model for a test catchment. Three different calibrations of STREAP were used against different products: gridded raingauge (TBR), weather radar (NIMROD), and a merged of the two. Analysis of the discharge and sediment yields from the model runs showed that the models run by STREAP calibrated by the different products were statistically significantly different, with the raingauge calibration producing 12.4 % more sediment on average over the 50-year period. The merged product produced results which were between the raingauge and radar products. The results demonstrate the importance of considering the selection of rainfall driving data on Landscape Evolution Modelling. Rainfall products are highly uncertain, different instruments will observe rainfall differently, and these uncertainties are clearly shown to cascade through the calibration of the rainfall generator and the Landscape Evolution Model. Merging raingauge and radar products is a common practise operationally, and by using features of both to calibrate the rainfall generator it is likely a more robust rainfall timeseries is produced.

Method for controlling a motor vehicle powertrain

DOEpatents

Burba, Joseph C.; Landman, Ronald G.; Patil, Prabhakar B.; Reitz, Graydon A.

1990-01-01

A multiple forward speed automatic transmission produces its lowest forward speed ratio when a hydraulic clutch and hydraulic brake are disengaged and a one-way clutch connects a ring gear to the transmission casing. Second forward speed ratio results when the hydraulic clutch is engaged to connect the ring gear to the planetary carrier of a second gear set. Reverse drive and regenerative operation result when an hydraulic brake fixes the planetary and the direction of power flow is reversed. Various sensors produce signals representing the position of the gear selector lever operated manually by the vehicle operator, the speed of the power source, the state of the ignition key, and the rate of release of an accelerator pedal. A control algorithm produces input data representing a commanded upshift, a commanded downshift and a torque command and various constant torque signals. A microprocessor processes the input and produces a response to them in accordance with the execution of a control algorithm. Output or response signals cause selective engagement and disengagement of the clutch and brake to produce the forward drive, reverse and regenerative operation of the transmission.

Method for controlling a motor vehicle powertrain

DOEpatents

Burba, J.C.; Landman, R.G.; Patil, P.B.; Reitz, G.A.

1990-05-22

A multiple forward speed automatic transmission produces its lowest forward speed ratio when a hydraulic clutch and hydraulic brake are disengaged and a one-way clutch connects a ring gear to the transmission casing. Second forward speed ratio results when the hydraulic clutch is engaged to connect the ring gear to the planetary carrier of a second gear set. Reverse drive and regenerative operation result when an hydraulic brake fixes the planetary and the direction of power flow is reversed. Various sensors produce signals representing the position of the gear selector lever operated manually by the vehicle operator, the speed of the power source, the state of the ignition key, and the rate of release of an accelerator pedal. A control algorithm produces input data representing a commanded upshift, a commanded downshift and a torque command and various constant torque signals. A microprocessor processes the input and produces a response to them in accordance with the execution of a control algorithm. Output or response signals cause selective engagement and disengagement of the clutch and brake to produce the forward drive, reverse and regenerative operation of the transmission. 7 figs.

Dynamic evolution and biogenesis of small RNAs during sex reversal.

PubMed

Liu, Jie; Luo, Majing; Sheng, Yue; Hong, Qiang; Cheng, Hanhua; Zhou, Rongjia

2015-05-06

Understanding origin, evolution and functions of small RNA (sRNA) genes has been a great challenge in the past decade. Molecular mechanisms underlying sexual reversal in vertebrates, particularly sRNAs involved in this process, are largely unknown. By deep-sequencing of small RNA transcriptomes in combination with genomic analysis, we identified a large amount of piRNAs and miRNAs including over 1,000 novel miRNAs, which were differentially expressed during gonad reversal from ovary to testis via ovotesis. Biogenesis and expressions of miRNAs were dynamically changed during the reversal. Notably, phylogenetic analysis revealed dynamic expansions of miRNAs in vertebrates and an evolutionary trajectory of conserved miR-17-92 cluster in the Eukarya. We showed that the miR-17-92 cluster in vertebrates was generated through multiple duplications from ancestor miR-92 in invertebrates Tetranychus urticae and Daphnia pulex from the Chelicerata around 580 Mya. Moreover, we identified the sexual regulator Dmrt1 as a direct target of the members miR-19a and -19b in the cluster. These data suggested dynamic biogenesis and expressions of small RNAs during sex reversal and revealed multiple expansions and evolutionary trajectory of miRNAs from invertebrates to vertebrates, which implicate small RNAs in sexual reversal and provide new insight into evolutionary and molecular mechanisms underlying sexual reversal.

Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species.

PubMed

Challis, Gregory L; Hopwood, David A

2003-11-25

In this article we briefly review theories about the ecological roles of microbial secondary metabolites and discuss the prevalence of multiple secondary metabolite production by strains of Streptomyces, highlighting results from analysis of the recently sequenced Streptomyces coelicolor and Streptomyces avermitilis genomes. We address this question: Why is multiple secondary metabolite production in Streptomyces species so commonplace? We argue that synergy or contingency in the action of individual metabolites against biological competitors may, in some cases, be a powerful driving force for the evolution of multiple secondary metabolite production. This argument is illustrated with examples of the coproduction of synergistically acting antibiotics and contingently acting siderophores: two well-known classes of secondary metabolite. We focus, in particular, on the coproduction of beta-lactam antibiotics and beta-lactamase inhibitors, the coproduction of type A and type B streptogramins, and the coregulated production and independent uptake of structurally distinct siderophores by species of Streptomyces. Possible mechanisms for the evolution of multiple synergistic and contingent metabolite production in Streptomyces species are discussed. It is concluded that the production by Streptomyces species of two or more secondary metabolites that act synergistically or contingently against biological competitors may be far more common than has previously been recognized, and that synergy and contingency may be common driving forces for the evolution of multiple secondary metabolite production by these sessile saprophytes.

Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species

PubMed Central

Challis, Gregory L.; Hopwood, David A.

2003-01-01

In this article we briefly review theories about the ecological roles of microbial secondary metabolites and discuss the prevalence of multiple secondary metabolite production by strains of Streptomyces, highlighting results from analysis of the recently sequenced Streptomyces coelicolor and Streptomyces avermitilis genomes. We address this question: Why is multiple secondary metabolite production in Streptomyces species so commonplace? We argue that synergy or contingency in the action of individual metabolites against biological competitors may, in some cases, be a powerful driving force for the evolution of multiple secondary metabolite production. This argument is illustrated with examples of the coproduction of synergistically acting antibiotics and contingently acting siderophores: two well-known classes of secondary metabolite. We focus, in particular, on the coproduction of β-lactam antibiotics and β-lactamase inhibitors, the coproduction of type A and type B streptogramins, and the coregulated production and independent uptake of structurally distinct siderophores by species of Streptomyces. Possible mechanisms for the evolution of multiple synergistic and contingent metabolite production in Streptomyces species are discussed. It is concluded that the production by Streptomyces species of two or more secondary metabolites that act synergistically or contingently against biological competitors may be far more common than has previously been recognized, and that synergy and contingency may be common driving forces for the evolution of multiple secondary metabolite production by these sessile saprophytes. PMID:12970466

Development and Test of HMPT-500

DTIC Science & Technology

1974-12-01

previot General Electric units in that reverse and low forward speeds use hydrostatic drive with the more efficient hydro- mechanical drive being...Infantry Combat Vehicle, X1723, having a gross weight of 40,000 pounds. 2. fabrication of a minimum of two HNPT-500 power trains capable of adaptation to...b. a 10,000-mile durability test with a vehicle of approximately 40,000 pounds weight . The detailed Scope of Work specified in the contract is

Direct Fusion Drive for a Human Mars Orbital Mission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paluszek, Michael; Pajer, Gary; Razin, Yosef

2014-08-01

The Direct Fusion Drive (DFD) is a nuclear fusion engine that produces both thrust and electric power. It employs a field reversed configuration with an odd-parity rotating magnetic field heating system to heat the plasma to fusion temperatures. The engine uses deuterium and helium-3 as fuel and additional deuterium that is heated in the scrape-off layer for thrust augmentation. In this way variable exhaust velocity and thrust is obtained.

The role of meiotic drive in hybrid male sterility.

PubMed

McDermott, Shannon R; Noor, Mohamed A F

2010-04-27

Meiotic drive causes the distortion of allelic segregation away from Mendelian expected ratios, often also reducing fecundity and favouring the evolution of drive suppressors. If different species evolve distinct drive-suppressor systems, then hybrid progeny may be sterile as a result of negative interactions of these systems' components. Although the hypothesis that meiotic drive may contribute to hybrid sterility, and thus species formation, fell out of favour early in the 1990s, recent results showing an association between drive and sterility have resurrected this previously controversial idea. Here, we review the different forms of meiotic drive and their possible roles in speciation. We discuss the recent empirical evidence for a link between drive and hybrid male sterility, also suggesting a possible mechanistic explanation for this link in the context of chromatin remodelling. Finally, we revisit the population genetics of drive that allow it to contribute to speciation.

The role of meiotic drive in hybrid male sterility

PubMed Central

McDermott, Shannon R.; Noor, Mohamed A. F.

2010-01-01

Meiotic drive causes the distortion of allelic segregation away from Mendelian expected ratios, often also reducing fecundity and favouring the evolution of drive suppressors. If different species evolve distinct drive-suppressor systems, then hybrid progeny may be sterile as a result of negative interactions of these systems' components. Although the hypothesis that meiotic drive may contribute to hybrid sterility, and thus species formation, fell out of favour early in the 1990s, recent results showing an association between drive and sterility have resurrected this previously controversial idea. Here, we review the different forms of meiotic drive and their possible roles in speciation. We discuss the recent empirical evidence for a link between drive and hybrid male sterility, also suggesting a possible mechanistic explanation for this link in the context of chromatin remodelling. Finally, we revisit the population genetics of drive that allow it to contribute to speciation. PMID:20308102

Driving and Neurodegenerative Diseases

PubMed Central

Uc, Ergun Y.; Rizzo, Matthew

2011-01-01

The proportion of elderly in the general population is rising, resulting in greater numbers of drivers with neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). These neurodegenerative disorders impair cognition, visual perception, and motor function, leading to reduced driver fitness and greater crash risk. Yet medical diagnosis or age alone is not reliable enough to predict driver safety or crashes, or revoke the driving privileges of these drivers. Driving research utilizes tools such as questionnaires about driving habits and history, driving simulators, standardized road tests utilizing instrumented vehicles, and state driving records. Research challenges include outlining the evolution of driving safety, understanding the mechanisms of driving impairment, and developing a reliable and efficient standardized test battery for prediction of driver safety in neurodegenerative disorders. This information will enable healthcare providers to advise their patients with neurodegenerative disorders with more certainty, affect policy, and help to develop rehabilitative measures for driving. PMID:18713573

Meiotic drive influences the outcome of sexually antagonistic selection at a linked locus.

PubMed

Patten, M M

2014-11-01

Most meiotic drivers, such as the t-haplotype in Mus and the segregation distorter (SD) in Drosophila, act in a sex-specific manner, gaining a transmission advantage through one sex although suffering only the fitness costs associated with the driver in the other. Their inheritance is thus more likely through one of the two sexes, a property they share with sexually antagonistic alleles. Previous theory has shown that pairs of linked loci segregating for sexually antagonistic alleles are more likely to remain polymorphic and that linkage disequilibrium accrues between them. I probe this similarity between drive and sexual antagonism and examine the evolution of chromosomes experiencing these selection pressures simultaneously. Reminiscent of previous theory, I find that: the opportunity for polymorphism increases for a sexually antagonistic locus that is physically linked to a driving locus; the opportunity for polymorphism at a driving locus also increases when linked to a sexually antagonistic locus; and stable linkage disequilibrium accompanies any polymorphic equilibrium. Additionally, I find that drive at a linked locus favours the fixation of sexually antagonistic alleles that benefit the sex in which drive occurs. Further, I show that under certain conditions reduced recombination between these two loci is selectively favoured. These theoretical results provide clear, testable predictions about the nature of sexually antagonistic variation on driving chromosomes and have implications for the evolution of genomic architecture. © 2014 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.

Chromosome-wide linkage disequilibrium as a consequence of meiotic drive

PubMed Central

Dyer, Kelly A.; Charlesworth, Brian; Jaenike, John

2007-01-01

Adaptation by natural selection proceeds most efficiently when alleles compete solely on the basis of their effects on the survival and reproduction of their carriers. A major condition for this is equal Mendelian segregation, but meiotic drive can short-circuit this process. The evolution of drive often involves multiple, interacting genetic components, together with enhancers and suppressors of drive. Chromosomal inversions that suppress crossing over are also frequently associated with drive systems. This study investigates the effects of these processes on patterns of molecular evolution in the fly Drosophila recens, which is polymorphic for a driving X chromosome (XD). Whereas standard wild-type chromosomes exhibit high levels of polymorphism at multiple loci, all of the XD chromosomes effectively carry a single multilocus haplotype that spans at least 130 cM. The XD is associated with a complex set of inversions that completely suppresses recombination between the standard wild-type chromosome and XD in heterozygous females, which maintain nonrandom associations among loci that presumably interact epistatically for the expression of drive. The long-term costs of foregoing recombination may be substantial; in combination with its low equilibrium frequency, this makes the XD chromosome susceptible to the accumulation of deleterious mutations. Consistent with this, XD chromosomes are apparently fixed for a recessive mutation that causes female sterility. Thus, the XD in D. recens appears to be in chromosome-wide linkage disequilibrium and in the early stages of mutational degradation. PMID:17242362

Mechanical Rectification of Oscillatory Motion for High Torque Microactuators

NASA Astrophysics Data System (ADS)

You, Liang; Tabib-Azar, Massood

2004-03-01

High-torque and scalable rotational micromotors were designed, microfabricated using a 3 mask LPCVD polysilicon process, and characterized. Oscillatory motions generated by comb-drive actuators were rectified by a rotor with fins. The actuator periodically deforms the fins generating forces with tangential and normal components in the rotor. Tangential forces generate rotation. In comparison to the electrostatic side-drive micromotor (torque pN-m), the measured torques for these micromotors were much larger and reached 4.5 µN-m at 200Vpp applied to the comb-drive at 1 KHz. Both the comb-drive and the finned rotor are second-order resonant structures that, when coupled, result in interesting dynamic that manifests itself as different excitation (forward, reverse, stepping, and chaotic) modes of the rotor.

Geomagnetic dipole strength and reversal rate over the past two million years.

PubMed

Valet, Jean-Pierre; Meynadier, Laure; Guyodo, Yohan

2005-06-09

Independent records of relative magnetic palaeointensity from sediment cores in different areas of the world can be stacked together to extract the evolution of the geomagnetic dipole moment and thus provide information regarding the processes governing the geodynamo. So far, this procedure has been limited to the past 800,000 years (800 kyr; ref. 3), which does not include any geomagnetic reversals. Here we present a composite curve that shows the evolution of the dipole moment during the past two million years. This reconstruction is in good agreement with the absolute dipole moments derived from volcanic lavas, which were used for calibration. We show that, at least during this period, the time-averaged field was higher during periods without reversals but the amplitude of the short-term oscillations remained the same. As a consequence, few intervals of very low intensity, and thus fewer instabilities, are expected during periods with a strong average dipole moment, whereas more excursions and reversals are expected during periods of weak field intensity. We also observe that the axial dipole begins to decay 60-80 kyr before reversals, but rebuilds itself in the opposite direction in only a few thousand years.

Subsurface geometry and evolution of the Seattle fault zone and the Seattle Basin, Washington

USGS Publications Warehouse

ten Brink, Uri S.; Molzer, P.C.; Fisher, M.A.; Blakely, R.J.; Bucknam, R.C.; Parsons, T.; Crosson, R.S.; Creager, K.C.

2002-01-01

The Seattle fault, a large, seismically active, east-west-striking fault zone under Seattle, is the best-studied fault within the tectonically active Puget Lowland in western Washington, yet its subsurface geometry and evolution are not well constrained. We combine several analysis and modeling approaches to study the fault geometry and evolution, including depth-converted, deep-seismic-reflection images, P-wave-velocity field, gravity data, elastic modeling of shoreline uplift from a late Holocene earthquake, and kinematic fault restoration. We propose that the Seattle thrust or reverse fault is accompanied by a shallow, antithetic reverse fault that emerges south of the main fault. The wedge enclosed by the two faults is subject to an enhanced uplift, as indicated by the boxcar shape of the shoreline uplift from the last major earthquake on the fault zone. The Seattle Basin is interpreted as a flexural basin at the footwall of the Seattle fault zone. Basin stratigraphy and the regional tectonic history lead us to suggest that the Seattle fault zone initiated as a reverse fault during the middle Miocene, concurrently with changes in the regional stress field, to absorb some of the north-south shortening of the Cascadia forearc. Kingston Arch, 30 km north of the Seattle fault zone, is interpreted as a more recent disruption arising within the basin, probably due to the development of a blind reverse fault.

Inverse tissue mechanics of cell monolayer expansion.

PubMed

Kondo, Yohei; Aoki, Kazuhiro; Ishii, Shin

2018-03-01

Living tissues undergo deformation during morphogenesis. In this process, cells generate mechanical forces that drive the coordinated cell motion and shape changes. Recent advances in experimental and theoretical techniques have enabled in situ measurement of the mechanical forces, but the characterization of mechanical properties that determine how these forces quantitatively affect tissue deformation remains challenging, and this represents a major obstacle for the complete understanding of morphogenesis. Here, we proposed a non-invasive reverse-engineering approach for the estimation of the mechanical properties, by combining tissue mechanics modeling and statistical machine learning. Our strategy is to model the tissue as a continuum mechanical system and to use passive observations of spontaneous tissue deformation and force fields to statistically estimate the model parameters. This method was applied to the analysis of the collective migration of Madin-Darby canine kidney cells, and the tissue flow and force were simultaneously observed by the phase contrast imaging and traction force microscopy. We found that our monolayer elastic model, whose elastic moduli were reverse-engineered, enabled a long-term forecast of the traction force fields when given the tissue flow fields, indicating that the elasticity contributes to the evolution of the tissue stress. Furthermore, we investigated the tissues in which myosin was inhibited by blebbistatin treatment, and observed a several-fold reduction in the elastic moduli. The obtained results validate our framework, which paves the way to the estimation of mechanical properties of living tissues during morphogenesis.

Sleep Better at Night...Back Up Your Data.

ERIC Educational Resources Information Center

Smith, Russell

1996-01-01

Discusses the need to back up computer files, and describes the technological evolution of back-up methods. Reviews tape drive and external hard drive back-up products offered by computer companies and presents back-up strategies to use with all back-up methods. A sidebar lists information on the reviewed products. (JMV)

The effect of selection environment on the probability of parallel evolution.

PubMed

Bailey, Susan F; Rodrigue, Nicolas; Kassen, Rees

2015-06-01

Across the great diversity of life, there are many compelling examples of parallel and convergent evolution-similar evolutionary changes arising in independently evolving populations. Parallel evolution is often taken to be strong evidence of adaptation occurring in populations that are highly constrained in their genetic variation. Theoretical models suggest a few potential factors driving the probability of parallel evolution, but experimental tests are needed. In this study, we quantify the degree of parallel evolution in 15 replicate populations of Pseudomonas fluorescens evolved in five different environments that varied in resource type and arrangement. We identified repeat changes across multiple levels of biological organization from phenotype, to gene, to nucleotide, and tested the impact of 1) selection environment, 2) the degree of adaptation, and 3) the degree of heterogeneity in the environment on the degree of parallel evolution at the gene-level. We saw, as expected, that parallel evolution occurred more often between populations evolved in the same environment; however, the extent of parallel evolution varied widely. The degree of adaptation did not significantly explain variation in the extent of parallelism in our system but number of available beneficial mutations correlated negatively with parallel evolution. In addition, degree of parallel evolution was significantly higher in populations evolved in a spatially structured, multiresource environment, suggesting that environmental heterogeneity may be an important factor constraining adaptation. Overall, our results stress the importance of environment in driving parallel evolutionary changes and point to a number of avenues for future work for understanding when evolution is predictable. © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Cell–cell signaling drives the evolution of complex traits: introduction—lung evo-devo

PubMed Central

Torday, John S.; Rehan, V. K.

2009-01-01

Physiology integrates biology with the environment through cell–cell interactions at multiple levels. The evolution of the respiratory system has been “deconvoluted” (Torday and Rehan in Am J Respir Cell Mol Biol 31:8–12, 2004) through Gene Regulatory Networks (GRNs) applied to cell–cell communication for all aspects of lung biology development, homeostasis, regeneration, and aging. Using this approach, we have predicted the phenotypic consequences of failed signaling for lung development, homeostasis, and regeneration based on evolutionary principles. This cell–cell communication model predicts other aspects of vertebrate physiology as adaptational responses. For example, the oxygen-induced differentiation of alveolar myocytes into alveolar adipocytes was critical for the evolution of the lung in land dwelling animals adapting to fluctuating Phanarezoic oxygen levels over the past 500 million years. Adipocytes prevent lung injury due to oxygen radicals and facilitate the rise of endothermy. In addition, they produce the class I cytokine leptin, which augments pulmonary surfactant activity and alveolar surface area, increasing selection pressure for both respiratory oxygenation and metabolic demand initially constrained by high-systemic vascular pressure, but subsequently compensated by the evolution of the adrenomedullary beta-adrenergic receptor mechanism. Conserted positive selection for the lung and adrenals created further selection pressure for the heart, which becomes progressively more complex phylogenetically in tandem with the lung. Developmentally, increasing heart complexity and size impinges precociously on the gut mesoderm to induce the liver. That evolutionary-developmental interaction is significant because the liver provides regulated sources of glucose and glycogen to the evolving physiologic system, which is necessary for the evolution of the neocortex. Evolution of neocortical control furthers integration of physiologic systems. Such an evolutionary vertical integration of cell-to-tissue-to-organ-to-physiology of intrinsic cell–cell signaling and extrinsic factors is the reverse of the “top-down” conventional way in which physiologic systems are usually regarded. This novel mechanistic approach, incorporating a “middle-out” cell–cell signaling component, will lead to a readily available algorithm for integrating genes and phenotypes. This symposium surveyed the phylogenetic origins of such vertically integrated mechanisms for the evolution of cell–cell communication as the basis for complex physiologic traits, from sponges to man. PMID:20607136

Magnetic bubbles and domain evolution in Fe/Gd multilayer nanodots

NASA Astrophysics Data System (ADS)

Wang, T. T.; Liu, W.; Dai, Z. M.; Zhao, X. T.; Zhao, X. G.; Zhang, Z. D.

2018-04-01

The formation of magnetic bubbles and the domain-evolution processes, induced by a perpendicular magnetic field in Fe/Gd multilayer films and nanodots, have been investigated. At room temperature, the stripe domains in a continuous film transform into magnetic bubbles in an external field, while bubbles form spontaneously in nanodots due to the existence of shape anisotropy. When the temperature decreases to 20 K, the enhancement of the perpendicular magnetic anisotropy of the samples results in an increase of the domain size in the continuous film and the magnetization-reversal behavior of each nanodot becomes independent, and most reversed dots do not depend on each other, indicating the magnetic characteristics of a single domain. The present research provides further understanding of the evolution of magnetic bubbles in the Fe/Gd system and suggests their promising applications in patterned recording materials.

Competition drives trait evolution and character displacement between Mimulus species along an environmental gradient.

PubMed

Kooyers, Nicholas J; James, Brooke; Blackman, Benjamin K

2017-05-01

Closely related species may evolve to coexist stably in sympatry through niche differentiation driven by in situ competition, a process termed character displacement. Alternatively, past evolution in allopatry may have already sufficiently reduced niche overlap to permit establishment in sympatry, a process called ecological sorting. The relative importance of each process to niche differentiation is contentious even though they are not mutually exclusive and are both mediated via multivariate trait evolution. We explore how competition has impacted niche differentiation in two monkeyflowers, Mimulus alsinoides and M. guttatus, which often co-occur. Through field observations, common gardens, and competition experiments, we demonstrate that M. alsinoides is restricted to marginal habitats in sympatry and that the impacts of character displacement on niche differentiation are complex. Competition with M. guttatus alters selection gradients and has favored taller M. alsinoides with earlier seasonal flowering at low elevation and floral shape divergence at high elevation. However, no trait exhibits the pattern typically associated with character displacement, higher divergence between species in sympatry than allopatry. Thus, although character displacement was unlikely the process driving initial divergence along niche axes necessary for coexistence, we conclude that competition in sympatry has likely driven trait evolution along additional niche axes. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

Mammals and habitat disturbance: the case of brown hare and wildfire.

PubMed

Sokos, Christos; Birtsas, Periklis; Papaspyropoulos, Konstantinos G; Tsachalidis, Efstathios; Giannakopoulos, Alexios; Milis, Chrysostomos; Spyrou, Vassiliki; Manolakou, Katerina; Valiakos, George; Iakovakis, Christos; Athanasiou, Labrini V; Sfougaris, Athanasios; Billinis, Charalambos

2016-10-01

Ecosystem disturbances, such as wildfires, are driving forces that determine ecology and conservation measures. Species respond differentially to wildfires, having diverse post-fire population evolution. This study reports, for first time, the responses of brown hare ( Lepus europaeus Pallas, 1778) to wildfires. Hare relative abundance, age ratio, diet quality, body condition, and diseases were studied. Fire influence on vegetation was calculated at a micro-scale level. Hare abundance was lower the first year after wildfires in burned relative to unburned areas. The reverse was found in the second year when hare abundance was higher in burned areas. Hare abundance in burned areas was also higher in the third and fourth years. In the fifth and sixth years after wildfire no significant difference was found in abundance. At a micro-scale level, higher numbers of hare feces were counted in places with greater wildfire influence on vegetation. Age ratio analysis revealed more juveniles in burned areas, but the same number of neonates in burned and unburned areas, indicating lower mortality of juveniles in burned areas. Reduced predation in burned areas provides the most plausible explanation for our findings.

Dynamic Photoelectrochemical Device Using an Electrolyte-Permeable NiO x/SiO2/Si Photocathode with an Open-Circuit Potential of 0.75 V.

PubMed

Jung, Jin-Young; Yu, Jin-Young; Lee, Jung-Ho

2018-03-07

As a thermodynamic driving force obtained from sunlight, the open-circuit potential (OCP) in photoelectrochemical cells is typically limited by the photovoltage ( V ph ). In this work, we establish that the OCP can exceed the value of V ph when an electrolyte-permeable NiO x thin film is employed as an electrocatalyst in a Si photocathode. The built-in potential developed at the NiO x /Si junction is adjusted in situ according to the progress of the NiO x hydration for the hydrogen evolution reaction (HER). As a result of decoupling of the OCP from V ph , a high OCP value of 0.75 V (vs reversible hydrogen electrode) is obtained after 1 h operation of HER in an alkaline electrolyte (pH = 14), thus outperforming the highest value (0.64 V) reported to date with conventional Si photoelectrodes. This finding might offer insight into novel photocathode designs such as those based on tandem water-splitting systems.

Organizational Data Mining

NASA Astrophysics Data System (ADS)

Nemati, Hamid R.; Barko, Christopher D.

Many organizations today possess substantial quantities of business information but have very little real business knowledge. A recent survey of 450 business executives reported that managerial intuition and instinct are more prevalent than hard facts in driving organizational decisions. To reverse this trend, businesses of all sizes would be well advised to adopt Organizational Data Mining (ODM). ODM is defined as leveraging Data Mining tools and technologies to enhance the decision-making process by transforming data into valuable and actionable knowledge to gain a competitive advantage. ODM has helped many organizations optimize internal resource allocations while better understanding and responding to the needs of their customers. The fundamental aspects of ODM can be categorized into Artificial Intelligence (AI), Information Technology (IT), and Organizational Theory (OT), with OT being the key distinction between ODM and Data Mining. In this chapter, we introduce ODM, explain its unique characteristics, and report on the current status of ODM research. Next we illustrate how several leading organizations have adopted ODM and are benefiting from it. Then we examine the evolution of ODM to the present day and conclude our chapter by contemplating ODM's challenging yet opportunistic future.

Value Creation Through Integrated Networks and Convergence

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Martini, Paul; Taft, Jeffrey D.

2015-04-01

Customer adoption of distributed energy resources and public policies are driving changes in the uses of the distribution system. A system originally designed and built for one-way energy flows from central generating facilities to end-use customers is now experiencing injections of energy from customers anywhere on the grid and frequent reversals in the direction of energy flow. In response, regulators and utilities are re-thinking the design and operations of the grid to create more open and transactive electric networks. This evolution has the opportunity to unlock significant value for customers and utilities. Alternatively, failure to seize this potential may insteadmore » lead to an erosion of value if customers seek to defect and disconnect from the system. This paper will discuss how current grid modernization investments may be leveraged to create open networks that increase value through the interaction of intelligent devices on the grid and prosumerization of customers. Moreover, even greater value can be realized through the synergistic effects of convergence of multiple networks. This paper will highlight examples of the emerging nexus of non-electric networks with electricity.« less

Climate change and temperature rise: implications on food- and water-borne diseases.

PubMed

El-Fadel, Mutasem; Ghanimeh, Sophia; Maroun, Rania; Alameddine, Ibrahim

2012-10-15

This study attempts to quantify climate-induced increases in morbidity rates associated with food- and water-borne illnesses in the context of an urban coastal city, taking Beirut-Lebanon as a study area. A Poisson generalized linear model was developed to assess the impacts of temperature on the morbidity rate. The model was used with four climatic scenarios to simulate a broad spectrum of driving forces and potential social, economic and technologic evolutions. The correlation established in this study exhibits a decrease in the number of illnesses with increasing temperature until reaching a threshold of 19.2 °C, beyond which the number of morbidity cases increases with temperature. By 2050, the results show a substantial increase in food- and water-borne related morbidity of 16 to 28% that can reach up to 42% by the end of the century under A1FI (fossil fuel intensive development) or can be reversed to ~0% under B1 (lowest emissions trajectory), highlighting the need for early mitigation and adaptation measures. Copyright © 2012 Elsevier B.V. All rights reserved.

Selective sweeps of mitochondrial DNA can drive the evolution of uniparental inheritance.

PubMed

Christie, Joshua R; Beekman, Madeleine

2017-08-01

Although the uniparental (or maternal) inheritance of mitochondrial DNA (mtDNA) is widespread, the reasons for its evolution remain unclear. Two main hypotheses have been proposed: selection against individuals containing different mtDNAs (heteroplasmy) and selection against "selfish" mtDNA mutations. Recently, uniparental inheritance was shown to promote adaptive evolution in mtDNA, potentially providing a third hypothesis for its evolution. Here, we explore this hypothesis theoretically and ask if the accumulation of beneficial mutations provides a sufficient fitness advantage for uniparental inheritance to invade a population in which mtDNA is inherited biparentally. In a deterministic model, uniparental inheritance increases in frequency but cannot replace biparental inheritance if only a single beneficial mtDNA mutation sweeps through the population. When we allow successive selective sweeps of mtDNA, however, uniparental inheritance can replace biparental inheritance. Using a stochastic model, we show that a combination of selection and drift facilitates the fixation of uniparental inheritance (compared to a neutral trait) when there is only a single selective mtDNA sweep. When we consider multiple mtDNA sweeps in a stochastic model, uniparental inheritance becomes even more likely to replace biparental inheritance. Our findings thus suggest that selective sweeps of beneficial mtDNA haplotypes can drive the evolution of uniparental inheritance. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

Design of Aircraft (Selected Chapters),

DTIC Science & Technology

1986-09-22

9 - compressed air motor of the drive of the reverser of the thrust of fan; 10 - flexible drive shaft; 11 - gearbox and jack; 12 - moving ring; 13...24 - cutoff and control valve; 25 - main line of pneumatic system; 26 - pneumo-starter; 27 - given by compressed air motor hydraulic pump; 28...kilometer; p - mass air density; p, - on the surface of sea; .A=p/p°- relative density of air ; R - radius of the Earth, a radius turn/bank and so forth; S

Quantum reversibility is relative, or does a quantum measurement reset initial conditions?

PubMed

Zurek, Wojciech H

2018-07-13

I compare the role of the information in classical and quantum dynamics by examining the relation between information flows in measurements and the ability of observers to reverse evolutions. I show that in the Newtonian dynamics reversibility is unaffected by the observer's retention of the information about the measurement outcome. By contrast-even though quantum dynamics is unitary, hence, reversible-reversing quantum evolution that led to a measurement becomes, in principle, impossible for an observer who keeps the record of its outcome. Thus, quantum irreversibility can result from the information gain rather than just its loss-rather than just an increase of the (von Neumann) entropy. Recording of the outcome of the measurement resets, in effect, initial conditions within the observer's (branch of) the Universe. Nevertheless, I also show that the observer's friend-an agent who knows what measurement was successfully carried out and can confirm that the observer knows the outcome but resists his curiosity and does not find out the result-can, in principle, undo the measurement. This relativity of quantum reversibility sheds new light on the origin of the arrow of time and elucidates the role of information in classical and quantum physics. Quantum discord appears as a natural measure of the extent to which dissemination of information about the outcome affects the ability to reverse the measurement.This article is part of a discussion meeting issue 'Foundations of quantum mechanics and their impact on contemporary society'. © 2018 The Author(s).

Forward and reverse mutagenesis in C. elegans

PubMed Central

Kutscher, Lena M.; Shaham, Shai

2014-01-01

Mutagenesis drives natural selection. In the lab, mutations allow gene function to be deciphered. C. elegans is highly amendable to functional genetics because of its short generation time, ease of use, and wealth of available gene-alteration techniques. Here we provide an overview of historical and contemporary methods for mutagenesis in C. elegans, and discuss principles and strategies for forward (genome-wide mutagenesis) and reverse (target-selected and gene-specific mutagenesis) genetic studies in this animal. PMID:24449699

Annual Report 2015: High Fidelity Modeling of Field-Reversed Configuration (FRC) Thrusters

DTIC Science & Technology

2016-06-01

simulations become unstable as time evolves leading to the magnetic island collision with the boundary and destruction of the close magnetic field structure...compares well with the results of the Hall-MHD code. 1 R. D. Milroy, "A magnetohydrodynamic model of rotating magnetic field current drive in a field...reversed configuration," Physics of Plasmas, vol. 7, no. 10. 2 Distribution A: Approved for Public Release. PA# 16202 Figure 1. Magnetic field

A new energy-efficient control approach for space telescope drive system

NASA Astrophysics Data System (ADS)

Zhou, Wangping; Wang, Yong

Drive control makes the telescope accurately track celestial bodies in spite of external and in-ternal disturbances, and is a key technique to the performance of telescopes. In this paper, we propose a nonlinear adaptive observer based on power reversible approach for high preci-sion position tracking, i.e., space telescopes. The nonlinear adaptive observer automatically estimates the disturbances in drive system, and the observed value is applied to compensate for the real disturbances. With greatly reduced disturbances, the control precision can be ev-idently improved. In conventional drive control, the brake device is often used to slow down the reaction wheel and may waste enormous energy. To avoid those disadvantages, an H-bridge is put forward for wheel speed regulation. Such H-bridge has four independent sections, and each section mainly consists of a power electronic switch and an anti-parallel diode. A pair of diagonal sections is switched on for speeding up the reaction wheel and the other pair act in reverse. During the period of the wheel slowing down, the armature current of drive motor goes through the two path-wise diodes to discharge the battery. Thusly, energy waste is avoided. Based on the disturbance compensation, an optimal controller is designed to minimize an eval-uation function which is made up of a weighted sum of position errors and energy consumption. The outputs of the controller are amplified to control the H-bridge. Simulations are performed in MATLAB language. The results show that high precision control can be obtained by the proposed approach. And the energy consumption will be remarkably reduced.

Social dilemmas among supergenes: intragenomic sexual conflict and a selfing solution in Oenothera.

PubMed

Brown, Sam P; Levin, Donald A

2011-12-01

Recombination is a powerful policing mechanism to control intragenomic cheats. The "parliament of the genes" can often rapidly block driving genes from cheating during meiosis. But what if the genome parliament is reduced to only two members, or supergenes? Using a series of simple game-theoretic models inspired by the peculiar genetics of Oenothera sp., we illustrate that a two supergene genome (α and β) can produce a number of surprising evolutionary dynamics, including increases in lineage longevity following a transition from sexuality (outcrossing) to asexuality (clonal self-fertilization). We end by interpreting the model in the broader context of the evolution of mutualism, which highlights that greater α, β cooperation in the self-fertilizing model can be viewed as an example of partner fidelity driving multilineage cooperation. © 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.

Blessing and curse of chaos in numerical turbulence simulations

NASA Astrophysics Data System (ADS)

Lee, Jon

1994-03-01

Because of the trajectory instability, time reversal is not possible beyond a certain evolution time and hence the time irreversibility prevails under the finite-accuracy trajectory computation. This therefore provides a practical reconciliation of the dynamic reversibility and macroscopic irreversibility (blessing of chaos). On the other hand, the trajectory instability is also responsible for a limited evolution time, so that finite-accuracy computation would yield a pseudo-orbit which is totally unrelated to the true trajectory (curse of chaos). For the inviscid 2D flow, however, we can accurately compute the long- time average of flow quantities with a pseudo-orbit by invoking the ergodic theorem.

Topological energy conversion through the bulk or the boundary of driven systems

NASA Astrophysics Data System (ADS)

Peng, Yang; Refael, Gil

2018-04-01

Combining physical and synthetic dimensions allows a controllable realization and manipulation of high-dimensional topological states. In our work, we introduce two quasiperiodically driven one-dimensional systems which enable tunable topological energy conversion between different driving sources. Using three drives, we realize a four-dimensional quantum Hall state which allows energy conversion between two of the drives within the bulk of the one-dimensional system. With only two drives, we achieve energy conversion between the two at the edge of the chain. Both effects are a manifestation of the effective axion electrodynamics in a three-dimensional time-reversal-invariant topological insulator. Furthermore, we explore the effects of disorder and commensurability of the driving frequencies, and show the phenomena are robust. We propose two experimental platforms, based on semiconductor heterostructures and ultracold atoms in optical lattices, in order to observe the topological energy conversion.

Empathizing-systemizing cognitive styles: Effects of sex and academic degree

PubMed Central

Kaganovskiy, Leon; Baron-Cohen, Simon

2018-01-01

This study tests if the drives to empathize (E) and systemize (S), measured by the Systemizing Quotient-Revised (SQ-R) and Empathy Quotient (EQ), show effects of sex and academic degree. The responses of 419 students from the Humanities and the Physical Sciences were analyzed in terms of the E-S theory predictions. Results confirm that there is an interaction between sex, degree and the drive to empathize relative to systemize. Female students in the Humanities on average had a stronger drive to empathize than to systemize in comparison to males in the Humanities. Male students in the Sciences on average had a stronger drive to systemize than to empathize in comparison to females in the Sciences. Finally, students in the sciences on average had a stronger drive to systemize more than to empathize, irrespective of their sex. The reverse is true for students in the Humanities. These results strongly replicate earlier findings. PMID:29579056

Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development.

PubMed

Gibbs, John P; Menon, Rajeev; Kasichayanula, Sreeneeranj

2018-02-01

With so much emphasis on reducing attrition and becoming more efficient in the delivery of healthcare, there are many opportunities to leverage existing clinical data in drug development and to foster the practice of reverse translation. The application of quantitative approaches to convert clinical trial and real-world data to knowledge will continue to drive innovation. Herein we discuss recent examples of reverse translation and consider future opportunities to capture critical clinical knowledge to inform decision-making in drug development. © 2017 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

Reverse-transformation austenite structure control with micro/nanometer size

NASA Astrophysics Data System (ADS)

Wu, Hui-bin; Niu, Gang; Wu, Feng-juan; Tang, Di

2017-05-01

To control the reverse-transformation austenite structure through manipulation of the micro/nanometer grain structure, the influences of cold deformation and annealing parameters on the microstructure evolution and mechanical properties of 316L austenitic stainless steel were investigated. The samples were first cold-rolled, and then samples deformed to different extents were annealed at different temperatures. The microstructure evolutions were analyzed by optical microscopy, scanning electron microscopy (SEM), magnetic measurements, and X-ray diffraction (XRD); the mechanical properties are also determined by tensile tests. The results showed that the fraction of stain-induced martensite was approximately 72% in the 90% cold-rolled steel. The micro/nanometric microstructure was obtained after reversion annealing at 820-870°C for 60 s. Nearly 100% reversed austenite was obtained in samples annealed at 850°C, where grains with a diameter ≤ 500 nm accounted for 30% and those with a diameter > 0.5 μm accounted for 70%. The micro/nanometer-grain steel exhibited not only a high strength level (approximately 959 MPa) but also a desirable elongation of approximately 45%.

Phase structures and morphologies of tempered CA6NM stainless steel welded by hybrid laser-arc process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mirakhorli, F., E-mail: Fatemeh.mirakhorli.1@ens.e

The post-weld tempered microstructure of hybrid laser-arc welded CA6NM, a cast low carbon martensitic stainless steel, was investigated. The microstructural evolutions from the fusion zone to the base metal were characterized in detail using optical microscopy, scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), X-ray diffraction (XRD) and microhardness techniques. The fusion zone, in its post-weld tempered condition, consisted of tempered lath martensite, residual delta-ferrite with various morphologies, reversed austenite and chromium carbides. The reversed austenite, which can be detected through both EBSD and XRD techniques, was found to be finely dispersed along the martensite lath boundaries, particularly at triplemore » junctions. Based on the EBSD analysis, the orientation relationship between the reversed austenite and the adjacent martensite laths seemed to follow the Kurdjumov-Sachs (K-S) model. The results also revealed the presence of the reversed austenite in the different regions of the heat affected zone after post-weld tempering. The microindentation hardness distribution was measured, and correlated to the evolution of the corresponding microstructure across the welds. - Highlights: •The EBSD analysis was performed on hybrid laser-arc welded CA6NM. •The FZ consisted of tempered lath martensite, reversed austenite, carbides and δ ferrite after tempering. •The reversed γ was formed along the α′ lath boundaries, particularly at triple junctions.« less

Five challenges in evolution and infectious diseases.

PubMed

Metcalf, C J E; Birger, R B; Funk, S; Kouyos, R D; Lloyd-Smith, J O; Jansen, V A A

2015-03-01

Evolution is a key aspect of the biology of many pathogens, driving processes ranging from immune escape to changes in virulence. Because evolution is inherently subject to feedbacks, and because pathogen evolution plays out at scales ranging from within-host to between-host and beyond, evolutionary questions provide special challenges to the modelling community. In this article, we provide an overview of five challenges in modelling the evolution of pathogens and their hosts, and point to areas for development, focussing in particular on the issue of linking theory and data. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

A Pooled Sequencing Approach Identifies a Candidate Meiotic Driver in Drosophila

PubMed Central

Wei, Kevin H.-C.; Reddy, Hemakumar M.; Rathnam, Chandramouli; Lee, Jimin; Lin, Deanna; Ji, Shuqing; Mason, James M.; Clark, Andrew G.; Barbash, Daniel A.

2017-01-01

Meiotic drive occurs when a selfish element increases its transmission frequency above the Mendelian ratio by hijacking the asymmetric divisions of female meiosis. Meiotic drive causes genomic conflict and potentially has a major impact on genome evolution, but only a few drive loci of large effect have been described. New methods to reliably detect meiotic drive are therefore needed, particularly for discovering moderate-strength drivers that are likely to be more prevalent in natural populations than strong drivers. Here, we report an efficient method that uses sequencing of large pools of backcross (BC1) progeny to test for deviations from Mendelian segregation genome-wide with single-nucleotide polymorphisms (SNPs) that distinguish the parental strains. We show that meiotic drive can be detected by a characteristic pattern of decay in distortion of SNP frequencies, caused by recombination unlinking the driver from distal loci. We further show that control crosses allow allele-frequency distortion caused by meiotic drive to be distinguished from distortion resulting from developmental effects. We used this approach to test whether chromosomes with extreme telomere-length differences segregate at Mendelian ratios, as telomeric regions are a potential hotspot for meiotic drive due to their roles in meiotic segregation and multiple observations of high rates of telomere sequence evolution. Using four different pairings of long and short telomere strains, we find no evidence that extreme telomere-length variation causes meiotic drive in Drosophila. However, we identify one candidate meiotic driver in a centromere-linked region that shows an ∼8% increase in transmission frequency, corresponding to a ∼54:46 segregation ratio. Our results show that candidate meiotic drivers of moderate strength can be readily detected and localized in pools of BC1 progeny. PMID:28258181

Hypoglycemia and safe driving

PubMed Central

Ahmed, Almoutaz A.

2010-01-01

The lack of awareness of the effects of hypoglycemia on safe driving is a real issue for diabetic patients and a challenge for health care providers. Taking the form of questions and answers, this review addresses the issue of road traffic accidents and drivers with type 1 diabetes mellitus. While there is little evidence showing higher accident rates among diabetic drivers, there is research indicating that hypoglycemia compromises driving performance, resulting in slower response times and reduced cognitive function. Unawareness of an early fall in plasma glucose is another important issue that affects some diabetic drivers. The driver with type 1 diabetes is obliged to check their blood glucose before driving. The physician’s duty is to familiarize the patient with the risk of hypoglycemia. If hypoglycemic unawareness is present, the physician should advise the patient to stop driving until the condition is reversed. The doctor should consider informing authorities if he concludes there is a risk and the driver cannot be persuaded to stop driving. PMID:21060159

Hypoglycemia and safe driving.

PubMed

Ahmed, Almoutaz A

2010-01-01

The lack of awareness of the effects of hypoglycemia on safe driving is a real issue for diabetic patients and a challenge for health care providers. Taking the form of questions and answers, this review addresses the issue of road traffic accidents and drivers with type 1 diabetes mellitus. While there is little evidence showing higher accident rates among diabetic drivers, there is research indicating that hypoglycemia compromises driving performance, resulting in slower response times and reduced cognitive function. Unawareness of an early fall in plasma glucose is another important issue that affects some diabetic drivers. The driver with type 1 diabetes is obliged to check their blood glucose before driving. The physician's duty is to familiarize the patient with the risk of hypoglycemia. If hypoglycemic unawareness is present, the physician should advise the patient to stop driving until the condition is reversed. The doctor should consider informing authorities if he concludes there is a risk and the driver cannot be persuaded to stop driving.

Modifications to the edge current profile with auxiliary edge current drive and improved confinement in a reversed-field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chapman, B. E.; Biewer, T. M.; Chattopadhyay, P. K.

2000-09-01

Auxiliary edge current drive is routinely applied in the Madison Symmetric Torus [R. N. Dexter, D. W. Kerst, T. W. Lovell et al., Fusion Technol. 19, 131 (1991)] with the goal of modifying the parallel current profile to reduce current-driven magnetic fluctuations and the associated particle and energy transport. Provided by an inductive electric field, the current drive successfully reduces fluctuations and transport. First-time measurements of the modified edge current profile reveal that, relative to discharges without auxiliary current drive, the edge current density decreases. This decrease is explicable in terms of newly measured reductions in the dynamo (fluctuation-based) electricmore » field and the electrical conductivity. Induced by the current drive, these two changes to the edge plasma play as much of a role in determining the resultant edge current profile as does the current drive itself. (c) 2000 American Institute of Physics.« less

Reversible Self-Assembly of Supramolecular Vesicles and Nanofibers Driven by Chalcogen-Bonding Interactions.

PubMed

Chen, Liang; Xiang, Jun; Zhao, Yue; Yan, Qiang

2018-05-29

Chalcogen-bonding interactions have been viewed as new noncovalent forces in supramolecular chemistry. However, harnessing chalcogen bonds to drive molecular self-assembly processes is still unexplored. Here we report for the first time a novel class of supra-amphiphiles formed by Te···O or Se···O chalcogen-bonding interactions, and their self-assembly into supramolecular vesicles and nanofibers. A quasi-calix[4]chalcogenadiazole (C4Ch) as macrocyclic donor and a tailed pyridine N-oxide surfactant as molecular acceptor are designed to construct the donor-acceptor complex via chalcogen-chalcogen connection between the chalcogenadiazole moieties and oxide anion. The affinity of such chalcogen-bonding can dictate the geometry of supra-amphiphiles, driving diverse self-assembled morphologies. Furthermore, the reversible disassembly of these nanostructures can be promoted by introducing competing anions, such as halide ions, or by decreasing the systemic pH value.

Cranial ontogenetic variation in early saurischians and the role of heterochrony in the diversification of predatory dinosaurs.

PubMed

Foth, Christian; Hedrick, Brandon P; Ezcurra, Martin D

2016-01-01

Non-avian saurischian skulls underwent at least 165 million years of evolution and shapes varied from elongated skulls, such as in the theropod Coelophysis, to short and box-shaped skulls, such as in the sauropod Camarasaurus. A number of factors have long been considered to drive skull shape, including phylogeny, dietary preferences and functional constraints. However, heterochrony is increasingly being recognized as an important factor in dinosaur evolution. In order to quantitatively analyse the impact of heterochrony on saurischian skull shape, we analysed five ontogenetic trajectories using two-dimensional geometric morphometrics in a phylogenetic framework. This allowed for the comparative investigation of main ontogenetic shape changes and the evaluation of how heterochrony affected skull shape through both ontogenetic and phylogenetic trajectories. Using principal component analyses and multivariate regressions, it was possible to quantify different ontogenetic trajectories and evaluate them for evidence of heterochronic events allowing testing of previous hypotheses on cranial heterochrony in saurischians. We found that the skull shape of the hypothetical ancestor of Saurischia likely led to basal Sauropodomorpha through paedomorphosis, and to basal Theropoda mainly through peramorphosis. Paedomorphosis then led from Orionides to Avetheropoda, indicating that the paedomorphic trend found by previous authors in advanced coelurosaurs may extend back into the early evolution of Avetheropoda. Not only are changes in saurischian skull shape complex due to the large number of factors that affected it, but heterochrony itself is complex, with a number of possible reversals throughout non-avian saurischian evolution. In general, the sampling of complete ontogenetic trajectories including early juveniles is considerably lower than the sampling of single adult or subadult individuals, which is a major impediment to the study of heterochrony on non-avian dinosaurs. Thus, the current work represents an exploratory analysis. To better understand the cranial ontogeny and the impact of heterochrony on skull evolution in saurischians, the data set that we present here must be expanded and complemented with further sampling from future fossil discoveries, especially of juvenile individuals.

Evolution of the long-wavelength, subduction-driven topography of South America since 150 Ma

NASA Astrophysics Data System (ADS)

Flament, N. E.; Gurnis, M.; Williams, S.; Bower, D. J.; Seton, M.; Müller, D.

2014-12-01

Subduction to the west of South America spans 6000 km along strike and has been active for over 250 Myr. The influence of the history of subduction on the geodynamics of South America has been profound, driving mountain building and arc volcanism in the Andean Cordillera. Here, we investigate the long-wavelength changes in the topography of South America associated with subduction and plate motion and their interplay with the lithospheric deformation associated with the opening of the South Atlantic. We pay particular attention to the topographic expression of flat-lying subduction zones. We develop time-dependent geodynamic models of mantle flow and lithosphere deformation to investigate the evolution of South American dynamic and total topography since the late Jurassic (150 Ma). Our models are semi-empirical because the computational cost of fully dynamic, evolutionary models is still prohibitive. We impose the kinematics of global plate reconstructions with deforming continents in forward global mantle convection models with compositionally distinct crust and continental lithosphere embedded within the thermal lithosphere. The shallow thermal structure of subducting slabs is imposed, allowing us to investigate the evolution of dynamic topography around flat slab segments in time-dependent models. Multiple cases are used to investigate how the evolution of South American dynamic topography is influenced by mantle viscosity, the kinematics of the opening of the South Atlantic and alternative scenarios for recent and past flat-slab subduction. We predict that the migration of South America over sinking oceanic lithosphere resulted in continental tilt to the west until ~ 45 Ma, inverting to an eastward tilt thereafter. This first-order result is consistent with the reversal of the drainage of the Amazon River system. We investigate which scenarios of flat-slab subduction since the Eocene are compatible with geological constraints on the evolution of the Solimoes Basin, the Chaco Basin, the Sierras Pampeanas and the Central Patagonian Basin. To broadly constrain mantle viscosity, we compare models to the total subsidence inferred from well data offshore Argentina and Brazil, and to mantle tomography, since the initial and boundary conditions are based on independent plate reconstructions.

Modelling the Evolution and Spread of HIV Immune Escape Mutants

PubMed Central

Fryer, Helen R.; Frater, John; Duda, Anna; Roberts, Mick G.; Phillips, Rodney E.; McLean, Angela R.

2010-01-01

During infection with human immunodeficiency virus (HIV), immune pressure from cytotoxic T-lymphocytes (CTLs) selects for viral mutants that confer escape from CTL recognition. These escape variants can be transmitted between individuals where, depending upon their cost to viral fitness and the CTL responses made by the recipient, they may revert. The rates of within-host evolution and their concordant impact upon the rate of spread of escape mutants at the population level are uncertain. Here we present a mathematical model of within-host evolution of escape mutants, transmission of these variants between hosts and subsequent reversion in new hosts. The model is an extension of the well-known SI model of disease transmission and includes three further parameters that describe host immunogenetic heterogeneity and rates of within host viral evolution. We use the model to explain why some escape mutants appear to have stable prevalence whilst others are spreading through the population. Further, we use it to compare diverse datasets on CTL escape, highlighting where different sources agree or disagree on within-host evolutionary rates. The several dozen CTL epitopes we survey from HIV-1 gag, RT and nef reveal a relatively sedate rate of evolution with average rates of escape measured in years and reversion in decades. For many epitopes in HIV, occasional rapid within-host evolution is not reflected in fast evolution at the population level. PMID:21124991

Propulsion of Active Colloids by Self-Induced Field Gradients.

PubMed

Boymelgreen, Alicia; Yossifon, Gilad; Miloh, Touvia

2016-09-20

Previously, metallodielectric Janus particles have been shown to travel with their dielectric hemisphere forward under low frequency applied electric fields as a result of asymmetric induced-charge electroosmotic flow. Here, it is demonstrated that at high frequencies, well beyond the charge relaxation time of the electric double layer induced around the particle, rather than the velocity decaying to zero, the Janus particles reverse direction, traveling with their metallic hemisphere forward. It is proposed that such motion is the result of a surface force, arising from localized nonuniform electric field gradients, induced by the dual symmetry-breaking of an asymmetric particle adjacent to a wall, which act on the induced dipole of the particle to drive net motion even in a uniform AC field. Although the field is external, since the driving gradient is induced on the particle level, it may be considered an active colloid. We have thus termed this propulsion mechanism "self-dielectrophoresis", to distinguish from traditional dielectrophoresis where the driving nonuniform field is externally fixed and the particle direction is restricted. It is demonstrated theoretically and experimentally that the critical frequency at which the particle reverses direction can be characterized by a nondimensional parameter which is a function of electrolyte concentration and particle size.

Low-foot rugby hohlraum experiments on the NIF: Wall-gas mix and a connection with missing x-ray drive energy?

NASA Astrophysics Data System (ADS)

Amendt, Peter; Ross, J. Steven; Schneider, Marilyn; Jones, Oggie; Milovich, Jose; Moody, John

2014-10-01

Rugby-shaped hohlraums on the NIF have shown strong symmetry anomalies when simulated with the high-flux model. The wall-gas interface is Rayleigh-Taylor unstable and may lead to the formation of a late-time mix layer that impedes inner- cone propagation, resulting in a drive asymmetry on the capsule. Due to the rugby curvature near the laser entrance hole, the effect of mix may be more pronounced than in cylinders. At the same time a persistent pattern of 15--25% missing energy has been inferred in gas-filled hohlraums (ρ >= 0 . 96 mg/cc). A possible physical connection between formation of a mix layer and the plasma adiabatic lapse rate, where a temperature-gradient reversal is predicted to occur, is explored. Such a profile reversal, in turn, hinders electron conduction to the dense (ρ > 0 . 2 g/cc) Au region responsible for ~900 eV drive x-ray emission, leading to a hotter coronal plasma and reduced hohlraum efficiency. Remedial measures for recovering the loss in hohlraum efficiency through the use of higher-Z gas fills are explored. Prepared by LLNL under Contract DE-AC52-07NA27344.

Role of viscous friction in the reverse rotation of a disk.

PubMed

de Castro, Pablo; Parisio, Fernando

2014-07-01

The mechanical response of a circularly driven disk in a dissipative medium is considered. We focus on the role played by viscous friction in the spinning motion of the disk, especially on the effect called reverse rotation, where the intrinsic and orbital rotations are antiparallel. Contrary to what happens in the frictionless case, where steady reverse rotations are possible, we find that this dynamical behavior may exist only as a transient when dissipation is considered. Whether or not reverse rotations in fact occur depends on the initial conditions and on two parameters, one related to dragging, inertia, and driving, the other associated with the geometric configuration of the system. The critical value of this geometric parameter (separating the regions where reverse rotation is possible from those where it is forbidden) as a function of viscosity is well adjusted by a q-exponential function.

Evolution of a Planar Wake in Adverse Pressure Gradient

NASA Technical Reports Server (NTRS)

Driver, David M.; Mateer, George G.

2016-01-01

In the interest of improving the predictability of high-lift systems at maximum lift conditions, a series of fundamental experiments were conducted to study the effects of adverse pressure gradient on a wake flow. Mean and fluctuating velocities were measured with a two-component laser-Doppler velocimeter. Data were obtained for several cases of adverse pressure gradient, producing flows ranging from no reversed flow to massively reversed flow. While the turbulent Reynolds stresses increase with increasing size of the reversed flow region, the gradient of Reynolds stress does not. Computations using various turbulence models were unable to reproduce the reversed flow.

Efficient Solar Energy Harvesting and Storage through a Robust Photocatalyst Driving Reversible Redox Reactions.

PubMed

Zhou, Yangen; Zhang, Shun; Ding, Yu; Zhang, Leyuan; Zhang, Changkun; Zhang, Xiaohong; Zhao, Yu; Yu, Guihua

2018-06-14

Simultaneous solar energy conversion and storage is receiving increasing interest for better utilization of the abundant yet intermittently available sunlight. Photoelectrodes driving nonspontaneous reversible redox reactions in solar-powered redox cells (SPRCs), which can deliver energy via the corresponding reverse reactions, present a cost-effective and promising approach for direct solar energy harvesting and storage. However, the lack of photoelectrodes having both high conversion efficiency and high durability becomes a bottleneck that hampers practical applications of SPRCs. Here, it is shown that a WO 3 -decorated BiVO 4 photoanode, without the need of extra electrocatalysts, can enable a single-photocatalyst-driven SPRC with a solar-to-output energy conversion efficiency as high as 1.25%. This SPRC presents stable performance over 20 solar energy storage/delivery cycles. The high efficiency and stability are attributed to the rapid redox reactions, the well-matched energy level, and the efficient light harvesting and charge separation of the prepared BiVO 4 . This demonstrated device system represents a potential alternative toward the development of low-cost, durable, and easy-to-implement solar energy technologies. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Four Phases of Russian Engineering Education in the Era of Social Experiments

ERIC Educational Resources Information Center

Churlyaeva, Natalya

2013-01-01

We consider some peculiarities in the evolution of Russian engineering education as it underwent two radical paradigmal transformations during the past century, especially from the viewpoint of restrictions that inhibited access to higher education (HE). The driving forces of this evolution are revealed and some negative results are shown. While…

ZOONET: perspectives on the evolution of animal form. Meeting report.

PubMed

Fischer, Antje H L; Arboleda, Enrique; Egger, Bernhard; Hilbrant, Maarten; McGregor, Alistair P; Cole, Alison G; Daley, Allison C

2009-11-15

What drives evolution? This was one of the main questions raised at the final ZOONET meeting in Budapest, Hungary, in November 2008. The meeting marked the conclusion of ZOONET, an EU-funded Marie-Curie Research Training Network comprising nine research groups from all over Europe (Max Telford, University College London; Michael Akam, University of Cambridge; Detlev Arendt, EMBL Heidelberg; Maria Ina Arnone, Stazione Zoologica Anton Dohrn Napoli; Michalis Averof, IMBB Heraklion; Graham Budd, Uppsala University; Richard Copley, University of Oxford; Wim Damen, University of Cologne; Ernst Wimmer, University of Göttingen). ZOONET meetings and practical courses held during the past four years provided researchers from diverse backgrounds--bioinformatics, phylogenetics, embryology, palaeontology, and developmental and molecular biology--the opportunity to discuss their work under a common umbrella of evolutionary developmental biology (Evo Devo). The Budapest meeting emphasized in-depth discussions of the key concepts defining Evo Devo, and bringing together ZOONET researchers with external speakers who were invited to present their views on the evolution of animal form. The discussion sessions addressed four main topics: the driving forces of evolution, segmentation, fossils and phylogeny, and the future of Evo Devo.

Design and analysis of forward and reverse models for predicting defect accumulation, defect energetics, and irradiation conditions

DOE PAGES

Stewart, James A.; Kohnert, Aaron A.; Capolungo, Laurent; ...

2018-03-06

The complexity of radiation effects in a material’s microstructure makes developing predictive models a difficult task. In principle, a complete list of all possible reactions between defect species being considered can be used to elucidate damage evolution mechanisms and its associated impact on microstructure evolution. However, a central limitation is that many models use a limited and incomplete catalog of defect energetics and associated reactions. Even for a given model, estimating its input parameters remains a challenge, especially for complex material systems. Here, we present a computational analysis to identify the extent to which defect accumulation, energetics, and irradiation conditionsmore » can be determined via forward and reverse regression models constructed and trained from large data sets produced by cluster dynamics simulations. A global sensitivity analysis, via Sobol’ indices, concisely characterizes parameter sensitivity and demonstrates how this can be connected to variability in defect evolution. Based on this analysis and depending on the definition of what constitutes the input and output spaces, forward and reverse regression models are constructed and allow for the direct calculation of defect accumulation, defect energetics, and irradiation conditions. Here, this computational analysis, exercised on a simplified cluster dynamics model, demonstrates the ability to design predictive surrogate and reduced-order models, and provides guidelines for improving model predictions within the context of forward and reverse engineering of mathematical models for radiation effects in a materials’ microstructure.« less

Design and analysis of forward and reverse models for predicting defect accumulation, defect energetics, and irradiation conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, James A.; Kohnert, Aaron A.; Capolungo, Laurent

The complexity of radiation effects in a material’s microstructure makes developing predictive models a difficult task. In principle, a complete list of all possible reactions between defect species being considered can be used to elucidate damage evolution mechanisms and its associated impact on microstructure evolution. However, a central limitation is that many models use a limited and incomplete catalog of defect energetics and associated reactions. Even for a given model, estimating its input parameters remains a challenge, especially for complex material systems. Here, we present a computational analysis to identify the extent to which defect accumulation, energetics, and irradiation conditionsmore » can be determined via forward and reverse regression models constructed and trained from large data sets produced by cluster dynamics simulations. A global sensitivity analysis, via Sobol’ indices, concisely characterizes parameter sensitivity and demonstrates how this can be connected to variability in defect evolution. Based on this analysis and depending on the definition of what constitutes the input and output spaces, forward and reverse regression models are constructed and allow for the direct calculation of defect accumulation, defect energetics, and irradiation conditions. Here, this computational analysis, exercised on a simplified cluster dynamics model, demonstrates the ability to design predictive surrogate and reduced-order models, and provides guidelines for improving model predictions within the context of forward and reverse engineering of mathematical models for radiation effects in a materials’ microstructure.« less

Electron Temperature Evolution During Local Helicity Injection on the Pegasus Toroidal Experiment

NASA Astrophysics Data System (ADS)

Schlossberg, D. J.; Barr, J. L.; Bodner, G. M.; Bongard, M. W.; Fonck, R. J.; Perry, J. M.; Reusch, J. A.; Rodriguez Sanchez, C.

2016-10-01

Understanding the electron temperature (Te) evolution during local helicity injection (LHI) is critical for scaling up this non-solenoidal startup technique to MA-class devices. The first comprehensive Te measurements during LHI reveal centrally-peaked profiles with Te > 100 eV for plasma current Ip > 120 kA, toroidal field 0.15 T, and electron density ne 1019 m-3. Te rises and is sustained from just after magnetic relaxation through the plasma decoupling from edge-localized injectors. Results are presented for two injector edge locations: outboard midplane and inboard divertor. Outboard midplane injection couples LHI with inductive drive from poloidal field ramps and radial compression during inward plasma growth. Comparisons of Te at different LHI-to-inductive drive ratios show some profile flattening for higher LHI drive fraction. The latter, constant-shape discharges were necessarily lower performance, with Ip 50 kA and reduced Te , max. Inboard divertor injection achieves higher Ip using minimal inductive drive and thus isolates effects of LHI drive on Te. Initial results in this configuration show Te rising rapidly at the injector location as the discharge grows, settling to a roughly flat profile 100 eV. Thus far, both scenarios provide relatively stable discharges with moderate ne and high-Te, suitable for coupling to auxiliary current drive. Detailed studies of confinement dynamics and discharge optimization are planned for the near future. Work supported by US DOE Grant DE-FG02-96ER54375.

Spin-orbit torque induced magnetic vortex polarity reversal utilizing spin-Hall effect

NASA Astrophysics Data System (ADS)

Li, Cheng; Cai, Li; Liu, Baojun; Yang, Xiaokuo; Cui, Huanqing; Wang, Sen; Wei, Bo

2018-05-01

We propose an effective magnetic vortex polarity reversal scheme that makes use of spin-orbit torque introduced by spin-Hall effect in heavy-metal/ferromagnet multilayers structure, which can result in subnanosecond polarity reversal without endangering the structural stability. Micromagnetic simulations are performed to investigate the spin-Hall effect driven dynamics evolution of magnetic vortex. The mechanism of magnetic vortex polarity reversal is uncovered by a quantitative analysis of exchange energy density, magnetostatic energy density, and their total energy density. The simulation results indicate that the magnetic vortex polarity is reversed through the nucleation-annihilation process of topological vortex-antivortex pair. This scheme is an attractive option for ultra-fast magnetic vortex polarity reversal, which can be used as the guidelines for the choice of polarity reversal scheme in vortex-based random access memory.

Enzyme engineering through evolution: thermostable recombinant group II intron reverse transcriptases provide new tools for RNA research and biotechnology.

PubMed

Collins, Kathleen; Nilsen, Timothy W

2013-08-01

Current investigation of RNA transcriptomes relies heavily on the use of retroviral reverse transcriptases. It is well known that these enzymes have many limitations because of their intrinsic properties. This commentary highlights the recent biochemical characterization of a new family of reverse transcriptases, those encoded by group II intron retrohoming elements. The novel properties of these enzymes endow them with the potential to revolutionize how we approach RNA analyses.

Family feuds: social competition and sexual conflict in complex societies

PubMed Central

Rubenstein, Dustin R.

2012-01-01

Darwin was initially puzzled by the processes that led to ornamentation in males—what he termed sexual selection—and those that led to extreme cooperation and altruism in complex animal societies—what was later termed kin selection. Here, I explore the relationships between sexual and kin selection theory by examining how social competition for reproductive opportunities—particularly in females—and sexual conflict over mating partners are inherent and critical parts of complex altruistic societies. I argue that (i) patterns of reproductive sharing within complex societies can drive levels of social competition and reproductive conflict not only in males but also in females living in social groups, and ultimately the evolution of female traits such as ornaments and armaments; (ii) mating conflict over female choice of sexual partners can influence kin structure within groups and drive the evolution of complex societies; and (iii) patterns of reproductive sharing and conflict among females may also drive the evolution of complex societies by influencing kin structure within groups. Ultimately, complex societies exhibiting altruistic behaviour appear to have only arisen in taxa where social competition over reproductive opportunities and sexual conflict over mating partners were low. Once such societies evolved, there were important selective feedbacks on traits used to regulate and mediate intra-sexual competition over reproductive opportunities, particularly in females. PMID:22777018

Family feuds: social competition and sexual conflict in complex societies.

PubMed

Rubenstein, Dustin R

2012-08-19

Darwin was initially puzzled by the processes that led to ornamentation in males-what he termed sexual selection-and those that led to extreme cooperation and altruism in complex animal societies-what was later termed kin selection. Here, I explore the relationships between sexual and kin selection theory by examining how social competition for reproductive opportunities-particularly in females-and sexual conflict over mating partners are inherent and critical parts of complex altruistic societies. I argue that (i) patterns of reproductive sharing within complex societies can drive levels of social competition and reproductive conflict not only in males but also in females living in social groups, and ultimately the evolution of female traits such as ornaments and armaments; (ii) mating conflict over female choice of sexual partners can influence kin structure within groups and drive the evolution of complex societies; and (iii) patterns of reproductive sharing and conflict among females may also drive the evolution of complex societies by influencing kin structure within groups. Ultimately, complex societies exhibiting altruistic behaviour appear to have only arisen in taxa where social competition over reproductive opportunities and sexual conflict over mating partners were low. Once such societies evolved, there were important selective feedbacks on traits used to regulate and mediate intra-sexual competition over reproductive opportunities, particularly in females.

Reversion of developmental mode in insects: evolution from long germband to short germband in the polyembrionic wasp Macrocentrus cingulum Brischke.

PubMed

Sucena, Élio; Vanderberghe, Koen; Zhurov, Vladimir; Grbić, Miodrag

2014-01-01

Germband size in insects has played a central role in our understanding of insect patterning mechanisms and their evolution. The polarity of evolutionary change in insect patterning has been viewed so far as the unidirectional shift from the ancestral short germband patterning of basal hemimetabolous insects to the long germband patterning observed in most modern Holometabola. However, some orders of holometabolic insects display both short and long germband development, though the absence of a clear phylogenetic context does not permit definite conclusions on the polarity of change. Derived hymenoptera, that is, bees and wasps, represent a classical textbook example of long germband development. Yet, in some wasps putative short germband development has been described correlating with lifestyle changes, namely with evolution of endoparasitism and polyembryony. To address the potential reversion from long to short germband, we focused on the family Braconidae, which displays ancestral long germband development, and examined the derived polyembryonic braconid Macrocentrus cingulum. Using SEM analysis of M. cingulum embryogenesis coupled with analyses of embryonic patterning markers, we show that this wasp evolved short germband embryogenesis secondarily, in a way that is reminiscent of embryogenesis in the beetle Tribolium castaneum. This work shows that the evolution of germband size in insects is a reversible process that may correlate with other life-history traits and suggests broader implications on the mechanisms and evolvability of insect development. © 2014 Wiley Periodicals, Inc.

A New LC-MS-based Strategy to integrate chemistry, morphology, and evolution of eggplant (Solanum) species

USDA-ARS?s Scientific Manuscript database

The economically valuable giant genus Solanum, containing dozens of functional food species such as eggplant and tomato, affords an excellent system to compare and correlate metabolic chemistry with species morphology and evolution. Here, we devised a strategy based on repeatable reversed-phase LC-T...

Protobiological informatoin, bidirectional recognition and reverse translation

NASA Technical Reports Server (NTRS)

Fox, S. W.; Nakashima, T.; Przybylski, A.; Vaughan, G.

1986-01-01

Emergence of protobiological information has been suggested by experiments in which heated mixtures of alpha-amino acids order themselves into a self limited array of thermal proteins. The polymers display selective catalytic, hormonal, and other activities. Interactions of varied cationic thermal proteins with polynucleotides indicate selective recognition in both directions. Reverse translation is partly a missing link in the molecular evolution flowsheet. The self ordering of amino acids serves conceptually as a deterministic evolutionary precursor of the modern coding mechanism. The possibility for the evolution of information at an early nontemplated protein stage is supported by findings of electrical signals from proteinoid microspheres prepared with no DNA/RNA in their history. The deposition of thermal copolyamino acids on lipid membranes in the Mueller-Rudin apparatus has here been found to produce electrical behavior like that evoked by bacterial EIM polypeptide. A new procedure is to make a film of membrane on the electrode; the results provide maximal repeatability. The principle of nonrandom biomacromolecular specificity identified by these studies in molecular evolution have been extrapolated to principles of evolution of advanced organisms.

Infalling clouds on to supermassive black hole binaries - II. Binary evolution and the final parsec problem

NASA Astrophysics Data System (ADS)

Goicovic, Felipe G.; Sesana, Alberto; Cuadra, Jorge; Stasyszyn, Federico

2017-11-01

The formation of massive black hole binaries (MBHBs) is an unavoidable outcome of galaxy evolution via successive mergers. However, the mechanism that drives their orbital evolution from parsec separations down to the gravitational wave dominated regime is poorly understood, and their final fate is still unclear. If such binaries are embedded in gas-rich and turbulent environments, as observed in remnants of galaxy mergers, the interaction with gas clumps (such as molecular clouds) may efficiently drive their orbital evolution. Using numerical simulations, we test this hypothesis by studying the dynamical evolution of an equal mass, circular MBHB accreting infalling molecular clouds. We investigate different orbital configurations, modelling a total of 13 systems to explore different possible impact parameters and relative inclinations of the cloud-binary encounter. We focus our study on the prompt, transient phase during the first few orbits when the dynamical evolution of the binary is fastest, finding that this evolution is dominated by the exchange of angular momentum through gas capture by the individual black holes and accretion. Building on these results, we construct a simple model for evolving an MBHB interacting with a sequence of clouds, which are randomly drawn from reasonable populations with different levels of anisotropy in their angular momenta distributions. We show that the binary efficiently evolves down to the gravitational wave emission regime within a few hundred million years, overcoming the 'final parsec' problem regardless of the stellar distribution.

Reverse Engineering Field Isolates of Myxoma Virus Demonstrates that Some Gene Disruptions or Losses of Function Do Not Explain Virulence Changes Observed in the Field

PubMed Central

Liu, June; Cattadori, Isabella M.; Sim, Derek G.; Eden, John-Sebastian; Read, Andrew F.

2017-01-01

ABSTRACT The coevolution of myxoma virus (MYXV) and wild European rabbits in Australia and Europe is a paradigm for the evolution of a pathogen in a new host species. Genomic analyses have identified the mutations that have characterized this evolutionary process, but defining causal mutations in the pathways from virulence to attenuation and back to virulence has not been possible. Using reverse genetics, we examined the roles of six selected mutations found in Australian field isolates of MYXV that fall in known or potential virulence genes. Several of these mutations occurred in genes previously identified as virulence genes in whole-gene knockout studies. Strikingly, no single or double mutation among the mutations tested had an appreciable impact on virulence. This suggests either that virulence evolution was defined by amino acid changes other than those analyzed here or that combinations of multiple mutations, possibly involving epistatic interactions or noncoding sequences, have been critical in the ongoing evolution of MYXV virulence. In sum, our results show that single-gene knockout studies of a progenitor virus can have little power to predict the impact of individual mutations seen in the field. The genetic determinants responsible for this canonical case of virulence evolution remain to be determined. IMPORTANCE The species jump of myxoma virus (MYXV) from the South American tapeti to the European rabbit populations of Australia and Europe is a canonical example of host-pathogen coevolution. Detailed molecular studies have identified multiple genes in MYXV that are critical for virulence, and genome sequencing has revealed the evolutionary history of MYXV in Australia and Europe. However, it has not been possible to categorically identify the key mutations responsible for the attenuation of or reversion to virulence during this evolutionary process. Here we use reverse genetics to examine the role of mutations in viruses isolated early and late in the Australian radiation of MYXV. Surprisingly, none of the candidate mutations that we identified as likely having roles in attenuation proved to be important for virulence. This indicates that considerable caution is warranted when interpreting the possible role of individual mutations during virulence evolution. PMID:28768866

Reverse resonance in stock prices of financial system with periodic information

NASA Astrophysics Data System (ADS)

Li, Jiang-Cheng; Mei, Dong-Cheng

2013-07-01

We investigate the stochastic resonance of the stock prices in a finance system with the Heston model. The extrinsic and intrinsic periodic information are introduced into the stochastic differential equations of the Heston model for stock price by focusing on the signal power amplification (SPA). We find that for both cases of extrinsic and intrinsic periodic information a phenomenon of reverse resonance emerges in the behaviors of SPA as a function of the system and external driving parameters. Moreover, in both cases, a phenomenon of double reverse resonance is observed in the behavior of SPA versus the amplitude of volatility fluctuations, by increasing the cross correlation between the noise sources in the Heston model.

Selfish X chromosomes and speciation.

PubMed

Patten, Manus M

2017-12-27

In two papers published at about the same time almost thirty years ago, Frank (Evolution, 45, 1991a, 262) and Hurst and Pomiankowski (Genetics, 128, 1991, 841) independently suggested that divergence of meiotic drive systems-comprising genes that cheat meiosis and genes that suppress this cheating-might provide a general explanation for Haldane's rule and the large X-effect in interspecific hybrids. Although at the time, the idea was met with skepticism and a conspicuous absence of empirical support, the tide has since turned. Some of the clearest mechanistic explanations we have for hybrid male sterility involve meiotic drive systems, and several other cases of hybrid sterility are suggestive of a role for meiotic drive. In this article, I review these ideas and their descendants and catalog the current evidence for the meiotic drive model of speciation. In addition, I suggest that meiotic drive is not the only intragenomic conflict to involve the X chromosome and contribute to hybrid incompatibility. Sexually and parentally antagonistic selection pressures can also pit the X chromosome and autosomes against each other. The resulting intragenomic conflicts should lead to co-evolution within populations and divergence between them, thus increasing the likelihood of incompatibilities in hybrids. I provide a sketch of these ideas and interpret some empirical patterns in the light of these additional X-autosome conflicts. © 2017 John Wiley & Sons Ltd.

Control of nonlinear systems using periodic parametric perturbations with application to a reversed field pinch

NASA Astrophysics Data System (ADS)

Mirus, Kevin Andrew

In this thesis, the possibility of controlling low- and high-dimensional chaotic systems by periodically driving an accessible system parameter is examined. This method has been carried out on several numerical systems and the MST Reversed Field Pinch. The numerical systems investigated include the logistic equation, the Lorenz equations, the Rossler equations, a coupled lattice of logistic equations, a coupled lattice of Lorenz equations, the Yoshida equations, which model tearing mode fluctuations in a plasma, and a neural net model for magnetic fluctuations on MST. This method was tested on the MST by sinusoidally driving a magnetic flux through the toroidal gap of the device. Numerically, periodic drives were found to be most effective at producing limit cycle behavior or significantly reducing the dimension of the system when the perturbation frequency was near natural frequencies of unstable periodic orbits embedded in the attractor of the unperturbed system. Several different unstable periodic orbits have been stabilized in this way for the low-dimensional numerical systems, sometimes with perturbation amplitudes that were less than 5% of the nominal value of the parameter being perturbed. In high- dimensional systems, limit cycle behavior and significant decreases in the system dimension were also achieved using perturbations with frequencies near the natural unstable periodic orbit frequencies. Results for the MST were not this encouraging, most likely because of an insufficient drive amplitude, the extremely high dimension of the plasma behavior, large amounts of noise, and a lack of stationarity in the transient plasma pulses.

How sexual selection can drive the evolution of costly sperm ornamentation

NASA Astrophysics Data System (ADS)

Lüpold, Stefan; Manier, Mollie K.; Puniamoorthy, Nalini; Schoff, Christopher; Starmer, William T.; Luepold, Shannon H. Buckley; Belote, John M.; Pitnick, Scott

2016-05-01

Post-copulatory sexual selection (PSS), fuelled by female promiscuity, is credited with the rapid evolution of sperm quality traits across diverse taxa. Yet, our understanding of the adaptive significance of sperm ornaments and the cryptic female preferences driving their evolution is extremely limited. Here we review the evolutionary allometry of exaggerated sexual traits (for example, antlers, horns, tail feathers, mandibles and dewlaps), show that the giant sperm of some Drosophila species are possibly the most extreme ornaments in all of nature and demonstrate how their existence challenges theories explaining the intensity of sexual selection, mating-system evolution and the fundamental nature of sex differences. We also combine quantitative genetic analyses of interacting sex-specific traits in D. melanogaster with comparative analyses of the condition dependence of male and female reproductive potential across species with varying ornament size to reveal complex dynamics that may underlie sperm-length evolution. Our results suggest that producing few gigantic sperm evolved by (1) Fisherian runaway selection mediated by genetic correlations between sperm length, the female preference for long sperm and female mating frequency, and (2) longer sperm increasing the indirect benefits to females. Our results also suggest that the developmental integration of sperm quality and quantity renders post-copulatory sexual selection on ejaculates unlikely to treat male-male competition and female choice as discrete processes.

Parasitism drives host genome evolution: Insights from the Pasteuria ramosa-Daphnia magna system.

PubMed

Bourgeois, Yann; Roulin, Anne C; Müller, Kristina; Ebert, Dieter

2017-04-01

Because parasitism is thought to play a major role in shaping host genomes, it has been predicted that genomic regions associated with resistance to parasites should stand out in genome scans, revealing signals of selection above the genomic background. To test whether parasitism is indeed such a major factor in host evolution and to better understand host-parasite interaction at the molecular level, we studied genome-wide polymorphisms in 97 genotypes of the planktonic crustacean Daphnia magna originating from three localities across Europe. Daphnia magna is known to coevolve with the bacterial pathogen Pasteuria ramosa for which host genotypes (clonal lines) are either resistant or susceptible. Using association mapping, we identified two genomic regions involved in resistance to P. ramosa, one of which was already known from a previous QTL analysis. We then performed a naïve genome scan to test for signatures of positive selection and found that the two regions identified with the association mapping further stood out as outliers. Several other regions with evidence for selection were also found, but no link between these regions and phenotypic variation could be established. Our results are consistent with the hypothesis that parasitism is driving host genome evolution. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

Age and visual impairment decrease driving performance as measured on a closed-road circuit.

PubMed

Wood, Joanne M

2002-01-01

In this study the effects of visual impairment and age on driving were investigated and related to visual function. Participants were 139 licensed drivers (young, middle-aged, and older participants with normal vision, and older participants with ocular disease). Driving performance was assessed during the daytime on a closed-road driving circuit. Visual performance was assessed using a vision testing battery. Age and visual impairment had a significant detrimental effect on recognition tasks (detection and recognition of signs and hazards), time to complete driving tasks (overall course time, reversing, and maneuvering), maneuvering ability, divided attention, and an overall driving performance index. All vision measures were significantly affected by group membership. A combination of motion sensitivity, useful field of view (UFOV), Pelli-Robson letter contrast sensitivity, and dynamic acuity could predict 50% of the variance in overall driving scores. These results indicate that older drivers with either normal vision or visual impairment had poorer driving performance compared with younger or middle-aged drivers with normal vision. The inclusion of tests such as motion sensitivity and the UFOV significantly improve the predictive power of vision tests for driving performance. Although such measures may not be practical for widespread screening, their application in selected cases should be considered.

Dispersive transport and symmetry of the dispersion tensor in porous media

NASA Astrophysics Data System (ADS)

Pride, Steven R.; Vasco, Donald W.; Flekkoy, Eirik G.; Holtzman, Ran

2017-04-01

The macroscopic laws controlling the advection and diffusion of solute at the scale of the porous continuum are derived in a general manner that does not place limitations on the geometry and time evolution of the pore space. Special focus is given to the definition and symmetry of the dispersion tensor that is controlling how a solute plume spreads out. We show that the dispersion tensor is not symmetric and that the asymmetry derives from the advective derivative in the pore-scale advection-diffusion equation. When flow is spatially variable across a voxel, such as in the presence of a permeability gradient, the amount of asymmetry can be large. As first shown by Auriault [J.-L. Auriault et al. Transp. Porous Med. 85, 771 (2010), 10.1007/s11242-010-9591-y] in the limit of low Péclet number, we show that at any Péclet number, the dispersion tensor Di j satisfies the flow-reversal symmetry Di j(+q ) =Dj i(-q ) where q is the mean flow in the voxel under analysis; however, Reynold's number must be sufficiently small that the flow is reversible when the force driving the flow changes sign. We also demonstrate these symmetries using lattice-Boltzmann simulations and discuss some subtle aspects of how to measure the dispersion tensor numerically. In particular, the numerical experiments demonstrate that the off-diagonal components of the dispersion tensor are antisymmetric which is consistent with the analytical dependence on the average flow gradients that we propose for these off-diagonal components.

Life and the solar uv environment on the early Earth

NASA Astrophysics Data System (ADS)

Bérces, A.; Kovács, G.; Rontó, G.; Lammer, H.; Kargl, G.; Kömle, N.; Bauer, S.

2003-04-01

The solar UV radiation environment on planetary surfaces and within their atmospheres is of importance in a wide range of scientific disciplines. Solar UV radiation is the driving force of chemical and organic evolution and serves also as a constraint in biological evolution. Studies of the solar UV environment of the early Earth 2.0 Gyr to 3.8 Gyr ago suggest that the terrestrial atmosphere was essentially anoxic, resulting in an ozone column abundance insufficient for protecting the planetary surface in the UV-B and the UV-C ranges. Since, short wavelength solar UV radiation in the UV-B ind UV-C range penetrated through the unprotected atmosphere to the surface on early Earth, associated biological consequences may be expected. For DNA-based terrestrial solar UV dosimetry, bacteriophage T7, isolated phage-DNA ind polycrystalline Uracil samples have been used. The effect of solar UV radiation can be measured by detecting the biological-structural consequences of the damage induced by UV photons. We show model calculations for the Biological Effective Dose (BED) rate of Uracil and bacteriophage T7, for various ozone concentrations representing early atmospheric conditions on Earth up to a UV protecting ozone layer comparable to present times. Further, we discuss experimental data which show the photo-reverse effect of Uracil molecules caused by short UV wavelengths. These photoreversion effect highly depend on the wavelength of the radiation. Shorter wavelength UV radiation of about 200 nm is strongly effective in monomerisation, while the longer wavelengths prefer the production of dimerisation. We could demonstrate experimentally, for the case of an Uracil thin-layer that the photo-reaction process of the nucleotides can be both, dimerization and the reverse process: monomerization. These results are important for the study of solar UV exposure on organisms in the terrestrial environment more than 2 Gyr ago where Earth had no UV protecting ozone layer as well as for the search for life on Mars since we can show that biological harmful effects can also be reduced by shorter wavelength UV radiation, which is of importance in reducing DNA damages provoked by wavelengths longer than about 240 nm.

Technological Evolution of High Temperature Superconductors

DTIC Science & Technology

2015-12-01

turbo-electric drive system (Navy 2015). Since then, naval warships have become increasingly more dependent on electrical power for weapons, sensors ...and propulsion as well, as the USS Makin Island became the first hybrid-electric ship that used gas turbine engines and electric motors to drive the... turbine generators (Naval Sea Systems Command 2013). As the demands for electrical power distribution throughout a ship has increased, the need for

Evolution of magnetic cataclysmic binaries

NASA Technical Reports Server (NTRS)

Lamb, Don Q.; Melia, F.

1988-01-01

The evolution of magnetic cataclysmic binaries is reviewed, with emphasis on the synchronization process by which DQ Herculis stars become AM Herculis stars. The various mechanisms that are thought to drive the evolution of cataclysmic binaries are discussed, and the criterion for stream versus disk accretion, the physics of the accretion and synchronization torques, and the conditions required for synchronization are described. The different physical regimes to which magnetic cataclysmic binaries belong are summarized, and how synchronization may be achieved, and how it may be broken, are considered.

Evolution of vaporizing pulsars

NASA Technical Reports Server (NTRS)

Mccormick, P.

1994-01-01

We construct evolutional scenarios for LMXB's using a simplified stellar model. We discuss the origin and evolution of short-period, low mass binary pulsars with evaporating companions. We suggest that these systems descend from low-mass X-ray binaries and that angular momentum loss mainly due to evaporative wind drives their evolution. We derive limits on the energy and angular momentum carried away by the wind based on the observed low eccentricity. In our model the companion remains near contact, and its quasiadiabatic expansion causes the binary to expand. Short-term oscillations of the orbital period may occur if the Roche-lobe overflow forms an evaporating disk.

Circulating type 1 vaccine-derived poliovirus may evolve under the pressure of adenosine deaminases acting on RNA.

PubMed

Liu, Yanhan; Ma, Tengfei; Liu, Jianzhu; Zhao, Xiaona; Cheng, Ziqiang; Guo, Huijun; Xu, Ruixue; Wang, Shujing

2015-01-01

Poliovirus, the causative agent of poliomyelitis, is a human enterovirus and member of the Picornaviridae family. An effective live-attenuated poliovirus vaccine strain (Sabin 1) has been developed and has protected humans from polio. However, a few cases of vaccine virulence reversion have been documented in several countries. For instance, circulating type 1 vaccine-derived poliovirus is a highly pathogenic poliovirus that evolved from an avirulent strain, but the mechanism by which vaccine strains undergo reversion remains unclear. In this study, vaccine strains exhibited A to G/U to C and G to A/C to U hypermutations in the reversed evolution of Sabin 1. Furthermore, the mutation ratios of U to C and C to U were higher than those of other mutation types. Dinucleotide editing context was then analyzed. Results showed that A to G and U to C mutations exhibited preferences similar to adenosine deaminases acting on RNA (ADAR). Hence, ADARs may participate in poliovirus vaccine evolution.

Evolution and Vaccination of Influenza Virus.

PubMed

Lam, Ham Ching; Bi, Xuan; Sreevatsan, Srinand; Boley, Daniel

2017-08-01

In this study, we present an application paradigm in which an unsupervised machine learning approach is applied to the high-dimensional influenza genetic sequences to investigate whether vaccine is a driving force to the evolution of influenza virus. We first used a visualization approach to visualize the evolutionary paths of vaccine-controlled and non-vaccine-controlled influenza viruses in a low-dimensional space. We then quantified the evolutionary differences between their evolutionary trajectories through the use of within- and between-scatter matrices computation to provide the statistical confidence to support the visualization results. We used the influenza surface Hemagglutinin (HA) gene for this study as the HA gene is the major target of the immune system. The visualization is achieved without using any clustering methods or prior information about the influenza sequences. Our results clearly showed that the evolutionary trajectories between vaccine-controlled and non-vaccine-controlled influenza viruses are different and vaccine as an evolution driving force cannot be completely eliminated.

Strategy evolution driven by switching probabilities in structured multi-agent systems

NASA Astrophysics Data System (ADS)

Zhang, Jianlei; Chen, Zengqiang; Li, Zhiqi

2017-10-01

Evolutionary mechanism driving the commonly seen cooperation among unrelated individuals is puzzling. Related models for evolutionary games on graphs traditionally assume that players imitate their successful neighbours with higher benefits. Notably, an implicit assumption here is that players are always able to acquire the required pay-off information. To relax this restrictive assumption, a contact-based model has been proposed, where switching probabilities between strategies drive the strategy evolution. However, the explicit and quantified relation between a player's switching probability for her strategies and the number of her neighbours remains unknown. This is especially a key point in heterogeneously structured system, where players may differ in the numbers of their neighbours. Focusing on this, here we present an augmented model by introducing an attenuation coefficient and evaluate its influence on the evolution dynamics. Results show that the individual influence on others is negatively correlated with the contact numbers specified by the network topologies. Results further provide the conditions under which the coexisting strategies can be calculated analytically.

Cultural selection drives the evolution of human communication systems

PubMed Central

Tamariz, Monica; Ellison, T. Mark; Barr, Dale J.; Fay, Nicolas

2014-01-01

Human communication systems evolve culturally, but the evolutionary mechanisms that drive this evolution are not well understood. Against a baseline that communication variants spread in a population following neutral evolutionary dynamics (also known as drift models), we tested the role of two cultural selection models: coordination- and content-biased. We constructed a parametrized mixed probabilistic model of the spread of communicative variants in four 8-person laboratory micro-societies engaged in a simple communication game. We found that selectionist models, working in combination, explain the majority of the empirical data. The best-fitting parameter setting includes an egocentric bias and a content bias, suggesting that participants retained their own previously used communicative variants unless they encountered a superior (content-biased) variant, in which case it was adopted. This novel pattern of results suggests that (i) a theory of the cultural evolution of human communication systems must integrate selectionist models and (ii) human communication systems are functionally adaptive complex systems. PMID:24966310

Cultural selection drives the evolution of human communication systems.

PubMed

Tamariz, Monica; Ellison, T Mark; Barr, Dale J; Fay, Nicolas

2014-08-07

Human communication systems evolve culturally, but the evolutionary mechanisms that drive this evolution are not well understood. Against a baseline that communication variants spread in a population following neutral evolutionary dynamics (also known as drift models), we tested the role of two cultural selection models: coordination- and content-biased. We constructed a parametrized mixed probabilistic model of the spread of communicative variants in four 8-person laboratory micro-societies engaged in a simple communication game. We found that selectionist models, working in combination, explain the majority of the empirical data. The best-fitting parameter setting includes an egocentric bias and a content bias, suggesting that participants retained their own previously used communicative variants unless they encountered a superior (content-biased) variant, in which case it was adopted. This novel pattern of results suggests that (i) a theory of the cultural evolution of human communication systems must integrate selectionist models and (ii) human communication systems are functionally adaptive complex systems.

Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit.

PubMed

Liu, Sha; Liu, Qili; Tabuchi, Masashi; Wu, Mark N

2016-06-02

Prolonged wakefulness leads to an increased pressure for sleep, but how this homeostatic drive is generated and subsequently persists is unclear. Here, from a neural circuit screen in Drosophila, we identify a subset of ellipsoid body (EB) neurons whose activation generates sleep drive. Patch-clamp analysis indicates these EB neurons are highly sensitive to sleep loss, switching from spiking to burst-firing modes. Functional imaging and translational profiling experiments reveal that elevated sleep need triggers reversible increases in cytosolic Ca(2+) levels, NMDA receptor expression, and structural markers of synaptic strength, suggesting these EB neurons undergo "sleep-need"-dependent plasticity. Strikingly, the synaptic plasticity of these EB neurons is both necessary and sufficient for generating sleep drive, indicating that sleep pressure is encoded by plastic changes within this circuit. These studies define an integrator circuit for sleep homeostasis and provide a mechanism explaining the generation and persistence of sleep drive. Copyright © 2016 Elsevier Inc. All rights reserved.

Return to drive after non-evolutive brain damage: French recommendations.

PubMed

D'apolito, Anne-Claire; Leguiet, Jean-Luc; Enjalbert, Michel; Lemoine, Francis; Mazaux, Jean-Michel

2017-07-01

Return to drive after brain damage is a crucial question either for patients than health professionals. The Société française de medicine physique et de réadaptation (SOFMER) and Comète France association developed recommandations for patient's identification, evaluation and accompaniment as part of their project to resume to drive. The place of rehabilitation process and patient's focus has been also discussed. Using a literature review, the aim was to define clinical pathways to determine people who need a fitness to drive evaluation after a non-evolutive brain damage as well as the assessment process. Following the method for Clinical practice guidelines, 1388 abstracts were identified, among which 379 were analysed and confronted with the working group's experience. The draft propositions were submitted to a review group before being validated by the High French Health Autority. No article enabled the development of recommendations above the "expert opinion". The detection of sensory (visual), sensitive, motor and/or cognitive sequelaes is needed before return to drive. It is not recommended to return to drive in case of unilateral spatial neglect. Different assessment strategies, function of sequeale's gravity, are proposed after stroke or brain injury. In case of sequeale, the assessment process (clinical, cognitive, on road evaluation) has to be pluriprofessional. The results are the subject of a pluriprofessional synthesis, shared with the patient and, if possible, in the presence of a close. An accompaniment to maintain the best mobility of the person is needed, whatever the assessment result. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Illusory motion reversal is caused by rivalry, not by perceptual snapshots of the visual field.

PubMed

Kline, Keith; Holcombe, Alex O; Eagleman, David M

2004-10-01

In stroboscopic conditions--such as motion pictures--rotating objects may appear to rotate in the reverse direction due to under-sampling (aliasing). A seemingly similar phenomenon occurs in constant sunlight, which has been taken as evidence that the visual system processes discrete "snapshots" of the outside world. But if snapshots are indeed taken of the visual field, then when a rotating drum appears to transiently reverse direction, its mirror image should always appeared to reverse direction simultaneously. Contrary to this hypothesis, we found that when observers watched a rotating drum and its mirror image, almost all illusory motion reversals occurred for only one image at a time. This result indicates that the motion reversal illusion cannot be explained by snapshots of the visual field. The same result is found when the two images are presented within one visual hemifield, further ruling out the possibility that discrete sampling of the visual field occurs separately in each hemisphere. The frequency distribution of illusory reversal durations approximates a gamma distribution, suggesting perceptual rivalry as a better explanation for illusory motion reversal. After adaptation of motion detectors coding for the correct direction, the activity of motion-sensitive neurons coding for motion in the reverse direction may intermittently become dominant and drive the perception of motion.

Magnetization Reversal Process of Single Crystal α-Fe Containing a Nonmagnetic Particle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yi; Xu, Ben; Hu, Shenyang Y.

2015-09-25

The magnetization reversal process and hysteresis loops in a single crystal α-iron with nonmagnetic particles are simulated in this work based on the Landau-Lifshitz–Gilbert equation. The evolutions of the magnetic domain morphology are studied, and our analyses show that the magnetization reversal process is affected by the interaction between the moving domain wall and the existing nonmagnetic particles. This interaction strongly depends on the size of the particles, and it is found that particles with a particular size contribute the most to magnetic hardening.

Analysis of ATP6 sequence diversity in the Triticum-Aegilops group of species reveals the crucial role of rearrangement in mitochondrial genome evolution

USDA-ARS?s Scientific Manuscript database

Mutation and chromosomal rearrangements are the two main forces of increasing genetic diversity for natural selection to act upon, and ultimately drive the evolutionary process. Although genome evolution is a function of both forces, simultaneously, the ratio of each can be varied among different ge...

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe.

PubMed

Margalef, Pol; Kotsantis, Panagiotis; Borel, Valerie; Bellelli, Roberto; Panier, Stephanie; Boulton, Simon J

2018-01-25

Telomere maintenance critically depends on the distinct activities of telomerase, which adds telomeric repeats to solve the end replication problem, and RTEL1, which dismantles DNA secondary structures at telomeres to facilitate replisome progression. Here, we establish that reversed replication forks are a pathological substrate for telomerase and the source of telomere catastrophe in Rtel1 -/- cells. Inhibiting telomerase recruitment to telomeres, but not its activity, or blocking replication fork reversal through PARP1 inhibition or depleting UBC13 or ZRANB3 prevents the rapid accumulation of dysfunctional telomeres in RTEL1-deficient cells. In this context, we establish that telomerase binding to reversed replication forks inhibits telomere replication, which can be mimicked by preventing replication fork restart through depletion of RECQ1 or PARG. Our results lead us to propose that telomerase inappropriately binds to and inhibits restart of reversed replication forks within telomeres, which compromises replication and leads to critically short telomeres. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Micromagnetic simulation of exchange coupled ferri-/ferromagnetic heterostructures

PubMed Central

Oezelt, Harald; Kovacs, Alexander; Reichel, Franz; Fischbacher, Johann; Bance, Simon; Gusenbauer, Markus; Schubert, Christian; Albrecht, Manfred; Schrefl, Thomas

2015-01-01

Exchange coupled ferri-/ferromagnetic heterostructures are a possible material composition for future magnetic storage and sensor applications. In order to understand the driving mechanisms in the demagnetization process, we perform micromagnetic simulations by employing the Landau–Lifshitz–Gilbert equation. The magnetization reversal is dominated by pinning events within the amorphous ferrimagnetic layer and at the interface between the ferrimagnetic and the ferromagnetic layer. The shape of the computed magnetization reversal loop corresponds well with experimental data, if a spatial variation of the exchange coupling across the ferri-/ferromagnetic interface is assumed. PMID:25937693

Synthesizing folded band chaos.

PubMed

Corron, Ned J; Hayes, Scott T; Pethel, Shawn D; Blakely, Jonathan N

2007-04-01

A randomly driven linear filter that synthesizes Lorenz-like, reverse-time chaos is shown also to produce Rössler-like folded band wave forms when driven using a different encoding of the random source. The relationship between the topological entropy of the random source, dissipation in the linear filter, and the positive Lyapunov exponent for the reverse-time wave form is exposed. The two drive encodings are viewed as grammar restrictions on a more general encoding that produces a chaotic superset encompassing both the Lorenz butterfly and Rössler folded band paradigms of nonlinear dynamics.

Apparatus for Pumping a Fluid

NASA Technical Reports Server (NTRS)

van Boeyen, Roger W. (Inventor); Reeh, Jonathan A. (Inventor); Kesmez, Mehmet (Inventor); Heselmeyer, Eric A. (Inventor); Parkey, Jeffrey S. (Inventor)

2016-01-01

An electrochemically actuated pump and an electrochemical actuator for use with a pump. The pump includes one of various stroke volume multiplier configurations with the pressure of a pumping fluid assisting actuation of a driving fluid bellows. The electrochemical actuator has at least one electrode fluidically coupled to the driving fluid chamber of the first pump housing and at least one electrode fluidically coupled to the driving fluid chamber of the second pump housing. Accordingly, the electrochemical actuator selectively pressurizes hydrogen gas within a driving fluid chamber. The actuator may include a membrane electrode assembly including an ion exchange membrane with first and second catalyzed electrodes in contact with opposing sides of the membrane, and first and second hydrogen gas chambers in fluid communication with the first and second electrodes, respectively. A controller may reverse the polarity of a voltage source electrically coupled to the current collectors.

Single mask, simple structure micro rotational motor driven by electrostatic comb-drive actuators

NASA Astrophysics Data System (ADS)

Pham, Phuc Hong; Viet Dao, Dzung; Dang, Lam Bao; Sugiyama, Susumu

2012-01-01

We report a design and fabrication of a new micro rotational motor (MRM) using silicon micromachining technology with the overall diameter of 2.4 mm. This motor utilizes four silicon electrostatic comb-drive actuators to drive the outer ring (or rotor) through ratchet teeth. The novel design of the anti-reverse structure helps us to overcome the gap problem after deep reactive ion etching of silicon. The MRM was fabricated by using silicon on insulator wafer with the thickness of the device layer being 30 µm and one mask only. The motor was successfully tested for performance. It was driven by periodic voltage with different frequencies ranging from 1 to 50 Hz. The angular velocity of the outer ratchet ring was proportional to the frequency. Moreover, when the driving frequency is lower than 30 Hz, the experiment results perfectly match the theoretical calculation.

Understanding Dali's Slave market with the disappearing bust of Voltaire: a case study in the scale information driving perception.

PubMed

Bonnar, Lizann; Gosselin, Frédéric; Schyns, Philippe G

2002-01-01

A generic problem in vision is to know which information drives the perception of a stimulus. We address this problem in a case study that involves the perceptual reversal of an ambiguous image (here, Dali's painting the Slave Market with the Disappearing Bust of Voltaire 1940). In experiment 1, we use 'bubbles' (Gosselin and Schyns, 2001 Vision Research 41 2261-2271) to disambiguate the image and to determine the specific visual information that drives each possible perception (here, the nuns versus the bust of Voltaire). Experiment 2 validates that this information does determine the selective perception of the ambiguous image. We adapted the spatial-frequency channels of observers selectively to the information that mediates one of the two perceptions, to induce the opposite perception of the ambiguous image in a transfer phase. Together, the results suggest a method of revealing the visual information that drives perception.

Reciprocating piston pump system with screw drive

NASA Technical Reports Server (NTRS)

Perkins, Gerald S. (Inventor); Moore, Nicholas R. (Inventor)

1981-01-01

A pump system of the reciprocating piston type is described, which facilitates direct motor drive and cylinder sealing. A threaded middle potion of the piston is engaged by a nut connected to rotate with the rotor of an electric motor, in a manner that minimizes loading on the rotor by the use of a coupling that transmits torque to the nut but permits it to shift axially and radially with respect to the rotor. The nut has a threaded hydrostatic bearing for engaging the threaded piston portion, with an oil-carrying groove in the nut being interrupted. A fluid emitting seal located at the entrance to each cylinder, can serve to center the piston within the cylinder, wash the piston, and to aid in sealing. The piston can have a long stroke to diameter ratio to minimize reciprocations and wear on valves at high pressures. The voltage applied to the motor can be reversed prior to the piston reaching the end of its stroke, to permit pressure on the piston to aid in reversing the motor.

Public good dynamics drive evolution of iron acquisition strategies in natural bacterioplankton populations.

PubMed

Cordero, Otto X; Ventouras, Laure-Anne; DeLong, Edward F; Polz, Martin F

2012-12-04

A common strategy among microbes living in iron-limited environments is the secretion of siderophores, which can bind poorly soluble iron and make it available to cells via active transport mechanisms. Such siderophore-iron complexes can be thought of as public goods that can be exploited by local communities and drive diversification, for example by the evolution of "cheating." However, it is unclear whether bacterial populations in the environment form stable enough communities such that social interactions significantly impact evolutionary dynamics. Here we show that public good games drive the evolution of iron acquisition strategies in wild populations of marine bacteria. We found that within nonclonal but ecologically cohesive genotypic clusters of closely related Vibrionaceae, only an intermediate percentage of genotypes are able to produce siderophores. Nonproducers within these clusters exhibited selective loss of siderophore biosynthetic pathways, whereas siderophore transport mechanisms were retained, suggesting that these nonproducers can act as cheaters that benefit from siderophore producers in their local environment. In support of this hypothesis, these nonproducers in iron-limited media suffer a significant decrease in growth, which can be alleviated by siderophores, presumably owing to the retention of transport mechanisms. Moreover, using ecological data of resource partitioning, we found that cheating coevolves with the ecological specialization toward association with larger particles in the water column, suggesting that these can harbor stable enough communities for dependencies among organisms to evolve.

Hydromechanical transmission

DOEpatents

Orshansky, Jr. deceased, Elias; Weseloh, William E.

1978-01-01

A power transmission having three planetary assemblies, each having its own carrier and its own planet, sun, and ring gears. A speed-varying module is connected in driving relation to the input shaft and in driving relationship to the three sun gears, all of which are connected together. The speed-varying means may comprise a pair of hydraulic units hydraulically interconnected so that one serves as a pump while the other serves as a motor and vice versa, one of the units having a variable stroke and being connected in driving relation to the input shaft, the other unit, which may have a fixed stroke, being connected in driving relation to the sun gears. The input shaft also drives the carrier of the third planetary assembly. A brake grounds the first carrier in the first range and in reverse and causes drive to be delivered to the output through the first ring gear in a hydrostatic mode. The carrier of the third planetary assembly drives the ring gear of the second planetary assembly, and a first clutching means connects the second carrier with the output in a second range, the brake for grounding the first carrier then being released. A second clutching means enables the third ring gear to drive the output shaft in a third range.

T Cell Adaptive Immunity Proceeds through Environment-Induced Adaptation from the Exposure of Cryptic Genetic Variation

PubMed Central

Whitacre, James M.; Lin, Joseph; Harding, Angus

2011-01-01

Evolution is often characterized as a process involving incremental genetic changes that are slowly discovered and fixed in a population through genetic drift and selection. However, a growing body of evidence is finding that changes in the environment frequently induce adaptations that are much too rapid to occur by an incremental genetic search process. Rapid evolution is hypothesized to be facilitated by mutations present within the population that are silent or “cryptic” within the first environment but are co-opted or “exapted” to the new environment, providing a selective advantage once revealed. Although cryptic mutations have recently been shown to facilitate evolution in RNA enzymes, their role in the evolution of complex phenotypes has not been proven. In support of this wider role, this paper describes an unambiguous relationship between cryptic genetic variation and complex phenotypic responses within the immune system. By reviewing the biology of the adaptive immune system through the lens of evolution, we show that T cell adaptive immunity constitutes an exemplary model system where cryptic alleles drive rapid adaptation of complex traits. In naive T cells, normally cryptic differences in T cell receptor reveal diversity in activation responses when the cellular population is presented with a novel environment during infection. We summarize how the adaptive immune response presents a well studied and appropriate experimental system that can be used to confirm and expand upon theoretical evolutionary models describing how seemingly small and innocuous mutations can drive rapid cellular evolution. PMID:22363338

Testing the Accuracy of Data-driven MHD Simulations of Active Region Evolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leake, James E.; Linton, Mark G.; Schuck, Peter W., E-mail: james.e.leake@nasa.gov

Models for the evolution of the solar coronal magnetic field are vital for understanding solar activity, yet the best measurements of the magnetic field lie at the photosphere, necessitating the development of coronal models which are “data-driven” at the photosphere. We present an investigation to determine the feasibility and accuracy of such methods. Our validation framework uses a simulation of active region (AR) formation, modeling the emergence of magnetic flux from the convection zone to the corona, as a ground-truth data set, to supply both the photospheric information and to perform the validation of the data-driven method. We focus ourmore » investigation on how the accuracy of the data-driven model depends on the temporal frequency of the driving data. The Helioseismic and Magnetic Imager on NASA’s Solar Dynamics Observatory produces full-disk vector magnetic field measurements at a 12-minute cadence. Using our framework we show that ARs that emerge over 25 hr can be modeled by the data-driving method with only ∼1% error in the free magnetic energy, assuming the photospheric information is specified every 12 minutes. However, for rapidly evolving features, under-sampling of the dynamics at this cadence leads to a strobe effect, generating large electric currents and incorrect coronal morphology and energies. We derive a sampling condition for the driving cadence based on the evolution of these small-scale features, and show that higher-cadence driving can lead to acceptable errors. Future work will investigate the source of errors associated with deriving plasma variables from the photospheric magnetograms as well as other sources of errors, such as reduced resolution, instrument bias, and noise.« less

The reverse evolution from multicellularity to unicellularity during carcinogenesis.

PubMed

Chen, Han; Lin, Fangqin; Xing, Ke; He, Xionglei

2015-03-09

Theoretical reasoning suggests that cancer may result from a knockdown of the genetic constraints that evolved for the maintenance of metazoan multicellularity. By characterizing the whole-life history of a xenograft tumour, here we show that metastasis is driven by positive selection for general loss-of-function mutations on multicellularity-related genes. Expression analyses reveal mainly downregulation of multicellularity-related genes and an evolving expression profile towards that of embryonic stem cells, the cell type resembling unicellular life in its capacity of unlimited clonal proliferation. Also, the emergence of metazoan multicellularity ~600 Myr ago is accompanied by an elevated birth rate of cancer genes, and there are more loss-of-function tumour suppressors than activated oncogenes in a typical tumour. These data collectively suggest that cancer represents a loss-of-function-driven reverse evolution back to the unicellular 'ground state'. This cancer evolution model may account for inter-/intratumoural genetic heterogeneity, could explain distant-organ metastases and hold implications for cancer therapy.

Super-Alfvénic translation of a field-reversed configuration into a large-bore dielectric chamber

NASA Astrophysics Data System (ADS)

Sekiguchi, J.; Asai, T.; Takahashi, T.

2018-01-01

An experimental device to demonstrate additional heating and control methods for a field-reversed configuration (FRC) has been developed. The newly developed device, named FRC Amplification via Translation (FAT), has a field-reversed theta-pinch plasma source and a low-elongation dielectric (transparent quartz) confinement chamber with quasi-static confinement field. In the initial experiments on the FAT device, FRC translation and trapping were successfully demonstrated. Although the typical elongation of the trapped FRC in the confinement region was roughly three, no disruptive global instability, such as tilt, was observed. The FAT device increases the latitude to perform translation-related experiments, such as those concerning inductive current drive, equivalent neutral beam injection effects, and wave applications.

Compatibility Study of Nanofiltration and Reverse Osmosis Membranes with 1 Cyclohexylpiperidenium Bicarbonate Solutions

DOE Data Explorer

Adhikari, Birendra; Jones, Michael G.; Orme, Christopher J.; Wendt, Daniel S.; Wilson, Aaron D.

2015-10-01

The switchable polarity solvent forward osmosis (SPS FO) desalination process requires use of a polishing filtration step to remove trace quantities of draw solution from the product water stream. Selected nanofiltration (NF) and reverse osmosis (RO) membranes were tested for their ability to recover water from 1-cyclohexylpiperidenium bicarbonate solutions in this application. This submission includes the experimental data used to calculate NF and RO membrane flux-normalized net driving pressure (FNNDP) and flux-normalized rejection (FNR) performance in recovering water from 1-cyclohexylpiperidenium bicarbonate solutions. This data is further described and visualized in the manuscript entitled "Compatibility study of nanofiltration and reverse osmosis membranes with 1 cyclohexylpiperidenium bicarbonate solutions" (see attached Compatibility Study Manuscript).

The reversed terminator of octopine synthase gene on the Agrobacterium Ti plasmid has a weak promoter activity in prokaryotes.

PubMed

Shao, Jun-Li; Long, Yue-Sheng; Chen, Gu; Xie, Jun; Xu, Zeng-Fu

2010-06-01

Agrobacterium tumefaciens transfers DNA from its Ti plasmid to plant host cells. The genes located within the transferred DNA of Ti plasmid including the octopine synthase gene (OCS) are expressed in plant host cells. The 3'-flanking region of OCS gene, known as OCS terminator, is widely used as a transcriptional terminator of the transgenes in plant expression vectors. In this study, we found the reversed OCS terminator (3'-OCS-r) could drive expression of hygromycin phosphotransferase II gene (hpt II) and beta-glucuronidase gene in Escherichia coli, and expression of hpt II in A. tumefaciens. Furthermore, reverse transcription-polymerase chain reaction analysis revealed that an open reading frame (ORF12) that is located downstream to the 3'-OCS-r was transcribed in A. tumefaciens, which overlaps in reverse with the coding region of the OCS gene in octopine Ti plasmid.

Centromere strength provides the cell biological basis for meiotic drive and karyotype evolution in mice.

PubMed

Chmátal, Lukáš; Gabriel, Sofia I; Mitsainas, George P; Martínez-Vargas, Jessica; Ventura, Jacint; Searle, Jeremy B; Schultz, Richard M; Lampson, Michael A

2014-10-06

Mammalian karyotypes (number and structure of chromosomes) can vary dramatically over short evolutionary time frames. There are examples of massive karyotype conversion, from mostly telocentric (centromere terminal) to mostly metacentric (centromere internal), in 10(2)-10(5) years. These changes typically reflect rapid fixation of Robertsonian (Rb) fusions, a common chromosomal rearrangement that joins two telocentric chromosomes at their centromeres to create one metacentric. Fixation of Rb fusions can be explained by meiotic drive: biased chromosome segregation during female meiosis in violation of Mendel's first law. However, there is no mechanistic explanation of why fusions would preferentially segregate to the egg in some populations, leading to fixation and karyotype change, while other populations preferentially eliminate the fusions and maintain a telocentric karyotype. Here we show, using both laboratory models and wild mice, that differences in centromere strength predict the direction of drive. Stronger centromeres, manifested by increased kinetochore protein levels and altered interactions with spindle microtubules, are preferentially retained in the egg. We find that fusions preferentially segregate to the polar body in laboratory mouse strains when the fusion centromeres are weaker than those of telocentrics. Conversely, fusion centromeres are stronger relative to telocentrics in natural house mouse populations that have changed karyotype by accumulating metacentric fusions. Our findings suggest that natural variation in centromere strength explains how the direction of drive can switch between populations. They also provide a cell biological basis of centromere drive and karyotype evolution. Copyright © 2014 Elsevier Ltd. All rights reserved.

A Sea-Floor Mystery: Mapping Polarity Reversals. Crustal Evolution Education Project. Teacher's Guide [and] Student Investigation.

ERIC Educational Resources Information Center

Stoever, Edward C., Jr.

Crustal Evolution Education Project (CEEP) modules were designed to: (1) provide students with the methods and results of continuing investigations into the composition, history, and processes of the earth's crust and the application of this knowledge to man's activities and (2) to be used by teachers with little or no previous background in the…

Mammals and habitat disturbance: the case of brown hare and wildfire

PubMed Central

Sokos, Christos; Birtsas, Periklis; Papaspyropoulos, Konstantinos G.; Tsachalidis, Efstathios; Giannakopoulos, Alexios; Milis, Chrysostomos; Spyrou, Vassiliki; Manolakou, Katerina; Valiakos, George; Iakovakis, Christos; Athanasiou, Labrini V.; Sfougaris, Athanasios; Billinis, Charalambos

2016-01-01

Abstract Ecosystem disturbances, such as wildfires, are driving forces that determine ecology and conservation measures. Species respond differentially to wildfires, having diverse post-fire population evolution. This study reports, for first time, the responses of brown hare (Lepus europaeus Pallas, 1778) to wildfires. Hare relative abundance, age ratio, diet quality, body condition, and diseases were studied. Fire influence on vegetation was calculated at a micro-scale level. Hare abundance was lower the first year after wildfires in burned relative to unburned areas. The reverse was found in the second year when hare abundance was higher in burned areas. Hare abundance in burned areas was also higher in the third and fourth years. In the fifth and sixth years after wildfire no significant difference was found in abundance. At a micro-scale level, higher numbers of hare feces were counted in places with greater wildfire influence on vegetation. Age ratio analysis revealed more juveniles in burned areas, but the same number of neonates in burned and unburned areas, indicating lower mortality of juveniles in burned areas. Reduced predation in burned areas provides the most plausible explanation for our findings. PMID:29491931

Ion energy balance in enhanced-confinement reversed-field pinch plasmas

NASA Astrophysics Data System (ADS)

Xing, Z. A.; Nornberg, M. D.; Boguski, J.; Craig, D.; den Hartog, D. J.; McCollam, K.

2017-10-01

Testing the applicability of collisional ion transport theory using tearing suppressed RFP plasma in MST achieved through Pulsed Poloidal Current Drive (PPCD), we find that the ion temperature dynamics in the core to be well-predicted by classical and collisional terms. Prior work demonstrated that impurity ion particle transport in PPCD plasmas is classical. Neoclassical effects on ions in the RFP are small and the stochastic transport is greatly suppressed during PPCD. Recent neutral modelling with DEGAS2 suggests higher core neutral temperatures than expected due to the preferential penetration of higher temperature neutrals generated by charge exchange. Further, investigations through equilibrium reconstruction point to the existence of an inward pinch flow associated with ExB drift. The heat balance model pulls together a wide range of diagnostic data to forward model Ti evolution in PPCD, which is then compared to charge exchange spectroscopy measurements of Ti. Ion power balance is mostly driven by classical effects including compressional heating, electron collisional heating, and charge exchange transport. This understanding provides a good baseline for investigations of anomalous heating in plasmas with tearing mode activity. This work is supported by US DOE.

Glutathione-capped gold nanoclusters as photosensitizers. Visible light-induced hydrogen generation in neutral water.

PubMed

Chen, Yong-Siou; Kamat, Prashant V

2014-04-23

Glutathione-capped metal nanoclusters (Aux-GSH NCs) which exhibit molecular-like properties are employed as a photosensitizer for hydrogen generation in a photoelectrochemical cell (PEC) and a photocatalytic slurry reactor. The reversible reduction (E(0) = -0.63 V vs RHE) and oxidation (E(0) = 0.97 and 1.51 V vs RHE) potentials of these metal nanoclusters make them suitable for driving the water-splitting reaction. When a mesoscopic TiO2 film sensitized by Aux-GSH NCs is used as the photoanode with a Pt counter electrode in aqueous buffer solution (pH = 7), we observe significant photocurrent activity under visible light (400-500 nm) excitation. Additionally, sensitizing Pt/TiO2 nanoparticles with Aux-GSH NCs in an aqueous slurry system and irradiating with visible light produce H2 at a rate of 0.3 mmol of hydrogen/h/g of Aux-GSH NCs. The rate of H2 evolution is significantly enhanced (∼5 times) when a sacrificial donor, such as EDTA, is introduced into the system. Using metal nanoclusters as a photosensitizer for hydrogen generation lays the foundation for the future exploration of other metal nanoclusters with well-controlled numbers of metal atoms and capping ligands.

Bar-spheroid interaction in galaxies

NASA Technical Reports Server (NTRS)

Hernquist, Lars; Weinberg, Martin D.

1992-01-01

N-body simulation and linear analysis is employed to investigate the secular evolution of barred galaxies, with emphasis on the interaction between bars and spheroidal components of galaxies. This interaction is argued to drive secular transfer of angular momentum from bars to spheroids, primarily through resonant coupling. A moderately strong bar, having mass within corotation about 0.3 times the enclosed spheroid mass, is predicted to shed all its angular momentum typically in less than about 10 exp 9 yr. Even shorter depletion time scales are found for relatively more massive bars. It is suggested either that spheroids around barred galaxies are structured so as to inhibit strong coupling with bars, or that bars can form by unknown processes long after disks are established. The present models reinforce the notion that bars can drive secular evolution in galaxies.

Genome-wide identification of the MADS-box transcription factor family in pear (Pyrus bretschneideri) reveals evolution and functional divergence.

PubMed

Wang, Runze; Ming, Meiling; Li, Jiaming; Shi, Dongqing; Qiao, Xin; Li, Leiting; Zhang, Shaoling; Wu, Jun

2017-01-01

MADS-box transcription factors play significant roles in plant developmental processes such as floral organ conformation, flowering time, and fruit development. Pear ( Pyrus ), as the third-most crucial temperate fruit crop, has been fully sequenced. However, there is limited information about the MADS family and its functional divergence in pear. In this study, a total of 95 MADS-box genes were identified in the pear genome, and classified into two types by phylogenetic analysis. Type I MADS-box genes were divided into three subfamilies and type II genes into 14 subfamilies. Synteny analysis suggested that whole-genome duplications have played key roles in the expansion of the MADS family, followed by rearrangement events. Purifying selection was the primary force driving MADS-box gene evolution in pear, and one gene pairs presented three codon sites under positive selection. Full-scale expression information for PbrMADS genes in vegetative and reproductive organs was provided and proved by transcriptional and reverse transcription PCR analysis. Furthermore, the PbrMADS11(12) gene, together with partners PbMYB10 and PbbHLH3 was confirmed to activate the promoters of the structural genes in anthocyanin pathway of red pear through dual luciferase assay. In addition, the PbrMADS11 and PbrMADS12 were deduced involving in the regulation of anthocyanin synthesis response to light and temperature changes. These results provide a solid foundation for future functional analysis of PbrMADS genes in different biological processes, especially of pigmentation in pear.

Genome-wide identification of the MADS-box transcription factor family in pear (Pyrus bretschneideri) reveals evolution and functional divergence

PubMed Central

Li, Jiaming; Shi, Dongqing; Qiao, Xin; Li, Leiting; Zhang, Shaoling

2017-01-01

MADS-box transcription factors play significant roles in plant developmental processes such as floral organ conformation, flowering time, and fruit development. Pear (Pyrus), as the third-most crucial temperate fruit crop, has been fully sequenced. However, there is limited information about the MADS family and its functional divergence in pear. In this study, a total of 95 MADS-box genes were identified in the pear genome, and classified into two types by phylogenetic analysis. Type I MADS-box genes were divided into three subfamilies and type II genes into 14 subfamilies. Synteny analysis suggested that whole-genome duplications have played key roles in the expansion of the MADS family, followed by rearrangement events. Purifying selection was the primary force driving MADS-box gene evolution in pear, and one gene pairs presented three codon sites under positive selection. Full-scale expression information for PbrMADS genes in vegetative and reproductive organs was provided and proved by transcriptional and reverse transcription PCR analysis. Furthermore, the PbrMADS11(12) gene, together with partners PbMYB10 and PbbHLH3 was confirmed to activate the promoters of the structural genes in anthocyanin pathway of red pear through dual luciferase assay. In addition, the PbrMADS11 and PbrMADS12 were deduced involving in the regulation of anthocyanin synthesis response to light and temperature changes. These results provide a solid foundation for future functional analysis of PbrMADS genes in different biological processes, especially of pigmentation in pear. PMID:28924499

Gene signature associated with benign neurofibroma transformation to malignant peripheral nerve sheath tumors

PubMed Central

Sorzano, Carlos O. S.; Pascual-Montano, Alberto; Carazo, Jose M.

2017-01-01

Benign neurofibromas, the main phenotypic manifestations of the rare neurological disorder neurofibromatosis type 1, degenerate to malignant tumors associated to poor prognosis in about 10% of patients. Despite efforts in the field of (epi)genomics, the lack of prognostic biomarkers with which to predict disease evolution frustrates the adoption of appropriate early therapeutic measures. To identify potential biomarkers of malignant neurofibroma transformation, we integrated four human experimental studies and one for mouse, using a gene score-based meta-analysis method, from which we obtained a score-ranked signature of 579 genes. Genes with the highest absolute scores were classified as promising disease biomarkers. By grouping genes with similar neurofibromatosis-related profiles, we derived panels of potential biomarkers. The addition of promoter methylation data to gene profiles indicated a panel of genes probably silenced by hypermethylation. To identify possible therapeutic treatments, we used the gene signature to query drug expression databases. Trichostatin A and other histone deacetylase inhibitors, as well as cantharidin and tamoxifen, were retrieved as putative therapeutic means to reverse the aberrant regulation that drives to malignant cell proliferation and metastasis. This in silico prediction corroborated reported experimental results that suggested the inclusion of these compounds in clinical trials. This experimental validation supported the suitability of the meta-analysis method used to integrate several sources of public genomic information, and the reliability of the gene signature associated to the malignant evolution of neurofibromas to generate working hypotheses for prognostic and drug-responsive biomarkers or therapeutic measures, thus showing the potential of this in silico approach for biomarker discovery. PMID:28542306

Evolution of reproductive proteins from animals and plants.

PubMed

Clark, Nathaniel L; Aagaard, Jan E; Swanson, Willie J

2006-01-01

Sexual reproduction is a fundamental biological process common among eukaryotes. Because of the significance of reproductive proteins to fitness, the diversity and rapid divergence of proteins acting at many stages of reproduction is surprising and suggests a role of adaptive diversification in reproductive protein evolution. Here we review the evolution of reproductive proteins acting at different stages of reproduction among animals and plants, emphasizing common patterns. Although we are just beginning to understand these patterns, by making comparisons among stages of reproduction for diverse organisms we can begin to understand the selective forces driving reproductive protein diversity and the functional consequences of reproductive protein evolution.

Iron catalysis at the origin of life.

PubMed

Camprubi, Eloi; Jordan, Sean F; Vasiliadou, Rafaela; Lane, Nick

2017-06-01

Iron-sulphur proteins are ancient and drive fundamental processes in cells, notably electron transfer and CO 2 fixation. Iron-sulphur minerals with equivalent structures could have played a key role in the origin of life. However, the 'iron-sulphur world' hypothesis has had a mixed reception, with questions raised especially about the feasibility of a pyrites-pulled reverse Krebs cycle. Phylogenetics suggests that the earliest cells drove carbon and energy metabolism via the acetyl CoA pathway, which is also replete in Fe(Ni)S proteins. Deep differences between bacteria and archaea in this pathway obscure the ancestral state. These differences make sense if early cells depended on natural proton gradients in alkaline hydrothermal vents. If so, the acetyl CoA pathway diverged with the origins of active ion pumping, and ancestral CO 2 fixation might have been equivalent to methanogens, which depend on a membrane-bound NiFe hydrogenase, energy converting hydrogenase. This uses the proton-motive force to reduce ferredoxin, thence CO 2 . The mechanism suggests that pH could modulate reduction potential at the active site of the enzyme, facilitating the difficult reduction of CO 2 by H 2 . This mechanism could be generalised under abiotic conditions so that steep pH differences across semi-conducting Fe(Ni)S barriers drives not just the first steps of CO 2 fixation to C1 and C2 organics such as CO, CH 3 SH and CH 3 COSH, but a series of similar carbonylation and hydrogenation reactions to form longer chain carboxylic acids such as pyruvate, oxaloacetate and α-ketoglutarate, as in the incomplete reverse Krebs cycle found in methanogens. We suggest that the closure of a complete reverse Krebs cycle, by regenerating acetyl CoA directly, displaced the acetyl CoA pathway from many modern groups. A later reliance on acetyl CoA and ATP eliminated the need for the proton-motive force to drive most steps of the reverse Krebs cycle. © 2017 IUBMB Life, 69(6):373-381, 2017. © 2017 The Authors IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology.

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

PubMed

Zambetti, Noemi A; Ping, Zhen; Chen, Si; Kenswil, Keane J G; Mylona, Maria A; Sanders, Mathijs A; Hoogenboezem, Remco M; Bindels, Eric M J; Adisty, Maria N; Van Strien, Paulina M H; van der Leije, Cindy S; Westers, Theresia M; Cremers, Eline M P; Milanese, Chiara; Mastroberardino, Pier G; van Leeuwen, Johannes P T M; van der Eerden, Bram C J; Touw, Ivo P; Kuijpers, Taco W; Kanaar, Roland; van de Loosdrecht, Arjan A; Vogl, Thomas; Raaijmakers, Marc H G P

2016-11-03

Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and relevance to human disease remain poorly defined. Here, we show that perturbation of mesenchymal cells in a mouse model of the pre-leukemic disorder Shwachman-Diamond syndrome (SDS) induces mitochondrial dysfunction, oxidative stress, and activation of DNA damage responses in hematopoietic stem and progenitor cells. Massive parallel RNA sequencing of highly purified mesenchymal cells in the SDS mouse model and a range of human pre-leukemic syndromes identified p53-S100A8/9-TLR inflammatory signaling as a common driving mechanism of genotoxic stress. Transcriptional activation of this signaling axis in the mesenchymal niche predicted leukemic evolution and progression-free survival in myelodysplastic syndrome (MDS), the principal leukemia predisposition syndrome. Collectively, our findings identify mesenchymal niche-induced genotoxic stress in heterotypic stem and progenitor cells through inflammatory signaling as a targetable determinant of disease outcome in human pre-leukemia. Copyright © 2016 Elsevier Inc. All rights reserved.

The Role of the Y-Chromosome in the Establishment of Murine Hybrid Dysgenesis and in the Analysis of the Nucleotide Sequence Organization, Genetic Transmission and Evolution of Repeated Sequences.

NASA Astrophysics Data System (ADS)

Nallaseth, Ferez Soli

The Y-chromosome presents a unique cytogenetic framework for the evolution of nucleotide sequences. Alignment of nine Y-chromosomal fragments in their increasing Y-specific/non Y-specific (male/female) sequence divergence ratios was directly and inversely related to their interspersion on these two respective genomic fractions. Sequence analysis confirmed a direct relationship between divergence ratios and the Alu, LINE-1, Satellite and their derivative oligonucleotide contents. Thus their relocation on the Y-chromosome is followed by sequence divergence rather than the well documented concerted evolution of these non-coding progenitor repeated sequences. Five of the nine Y-chromosomal fragments are non-pseudoautosomal and transcribed into heterogeneous PolyA^+ RNA and thus can be retrotransposed. Evolutionary and computer analysis identified homologous oligonucleotide tracts in several human loci suggesting common and random mechanistic origins. Dysgenic genomes represent the accelerated evolution driving sequence divergence (McClintock, 1984). Sex reversal and sterility characterizing dysgenesis occurs in C57BL/6JY ^{rm Pos} but not in 129/SvY^{rm Pos} derivative strains. High frequency, random, multi-locus deletion products of the feral Y^{ rm Pos}-chromosome are generated in the germlines of F1(C57BL/6J X 129/SvY^{ rm Pos})(male) and C57BL/6JY ^{rm Pos}(male) but not in 129/SvY^{rm Pos}(male). Equal, 10^{-1}, 10^ {-2}, and 0 copies (relative to males) of Y^{rm Pos}-specific deletion products respectively characterize C57BL/6JY ^{rm Pos} (HC), (LC), (T) and (F) females. The testes determining loci of inactive Y^{rm Pos}-chromosomes in C57BL/6JY^{rm Pos} HC females are the preferentially deleted/rearranged Y ^{rm Pos}-sequences. Disruption of regulation of plasma testosterone and hepatic MUP-A mRNA levels, TRD of a 4.7 Kbp EcoR1 fragment suggest disruption of autosomal/X-chromosomal sequences. These data and the highly repeated progenitor (Alu, GATA, LINE-1) sequence content of deletion products confirmed the previously unidentified loss of genetic control of mammalian chromosome biology and hybrid dysgenesis.

Recurrent Reverse Evolution Maintains Polymorphism after Strong Bottlenecks in Commensal Gut Bacteria

PubMed Central

Ramiro, Ricardo S.; Barroso-Batista, João; Güleresi, Daniela; Lourenço, Marta; Gordo, Isabel

2017-01-01

Abstract The evolution of new strains within the gut ecosystem is poorly understood. We used a natural but controlled system to follow the emergence of intraspecies diversity of commensal Escherichia coli, during three rounds of adaptation to the mouse gut (∼1,300 generations). We previously showed that, in the first round, a strongly beneficial phenotype (loss-of-function for galactitol consumption; gat-negative) spread to >90% frequency in all colonized mice. Here, we show that this loss-of-function is repeatedly reversed when a gat-negative clone colonizes new mice. The regain of function occurs via compensatory mutation and reversion, the latter leaving no trace of past adaptation. We further show that loss-of-function adaptive mutants reevolve, after colonization with an evolved gat-positive clone. Thus, even under strong bottlenecks a regime of strong-mutation-strong-selection dominates adaptation. Coupling experiments and modeling, we establish that reverse evolution recurrently generates two coexisting phenotypes within the microbiota that can or not consume galactitol (gat-positive and gat-negative, respectively). Although the abundance of the dominant strain, the gat-negative, depends on the microbiota composition, gat-positive abundance is independent of the microbiota composition and can be precisely manipulated by supplementing the diet with galactitol. These results show that a specific diet is able to change the abundance of specific strains. Importantly, we find polymorphism for these phenotypes in indigenous Enterobacteria of mice and man. Our results demonstrate that natural selection can greatly overwhelm genetic drift at structuring the strain diversity of gut commensals and that competition for limiting resources may be a key mechanism for maintaining polymorphism in the gut. PMID:28961745

A gaussian model for simulated geomagnetic field reversals

NASA Astrophysics Data System (ADS)

Wicht, Johannes; Meduri, Domenico G.

2016-10-01

Field reversals are the most spectacular events in the geomagnetic history but remain little understood. Here we explore the dipole behaviour in particularly long numerical dynamo simulations to reveal statistically significant conditions required for reversals and excursions to happen. We find that changes in the axial dipole moment behaviour are crucial while the equatorial dipole moment plays a negligible role. For small Rayleigh numbers, the axial dipole always remains strong and stable and obeys a clearly Gaussian probability distribution. Only when the Rayleigh number is increased sufficiently the axial dipole can reverse and its distribution becomes decisively non-Gaussian. Increased likelihoods around zero indicate a pronounced lingering in a new low dipole moment state. Reversals and excursions can only happen when axial dipole fluctuations are large enough to drive the system from the high dipole moment state assumed during stable polarity epochs into the low dipole moment state. Since it is just a matter of chance which polarity is amplified during dipole recovery, reversals and grand excursions, i.e. excursions during which the dipole assumes reverse polarity, are equally likely. While the overall reversal behaviour seems Earth-like, a closer comparison to palaeomagnetic findings suggests that the simulated events last too long and that grand excursions are too rare. For a particularly large Ekman number we find a second but less Earth-like type of reversals where the total field decays and recovers after a certain time.

Evolution of inhibitor-resistant natural mutant forms of HIV-1 protease probed by pre-steady state kinetic analysis.

PubMed

Zakharova, Maria Yu; Kuznetsova, Alexandra A; Kaliberda, Elena N; Dronina, Maria A; Kolesnikov, Alexander V; Kozyr, Arina V; Smirnov, Ivan V; Rumsh, Lev D; Fedorova, Olga S; Knorre, Dmitry G; Gabibov, Alexander G; Kuznetsov, Nikita A

2017-11-01

Pre-steady state kinetic analysis of mechanistic features of substrate binding and processing is crucial for insight into the evolution of inhibitor-resistant forms of HIV-1 protease. These data may provide a correct vector for rational drug design assuming possible intrinsic dynamic effects. These data should also give some clues to the molecular mechanism of protease action and resistance to inhibitors. Here we report pre-steady state kinetics of the interaction of wild type or mutant forms of HIV-1 protease with a FRET-labeled peptide. The three-stage "minimal" kinetic scheme with first and second reversible steps of substrate binding and with following irreversible peptide cleavage step adequately described experimental data. For the first time, a set of "elementary" kinetic parameters of wild type HIV-1 protease and its natural mutant inhibitor-resistant forms MDR-HM, ANAM-11 and prDRV4 were compared. Inhibitors of the first and second generation were used to estimate the inhibitory effects on HIV-1 protease activity. The resulting set of kinetic data supported that the mutant forms are kinetically unaffected by inhibitors of the first generation, proving their functional resistance to these compounds. The second generation inhibitor darunavir inhibited mutant forms MDR-HM and ANAM-11, but was ineffective against prDRV4. Our kinetic data revealed that these inhibitors induced different conformational changes in the enzyme and, thereby they have different mode of binding in the enzyme active site. These data confirmed hypothesis that the driving force of the inhibitor-resistance evolution is disruption of enzyme-inhibitor complex by changing of the contact network in the inhibitor binding site. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Homeotic Evolution in the Mammalia: Diversification of Therian Axial Seriation and the Morphogenetic Basis of Human Origins

PubMed Central

Filler, Aaron G.

2007-01-01

Background Despite the rising interest in homeotic genes, little has been known about the course and pattern of evolution of homeotic traits across the mammalian radiation. An array of emerging and diversifying homeotic gradients revealed by this study appear to generate new body plans and drive evolution at a large scale. Methodology/Principal Findings This study identifies and evaluates a set of homeotic gradients across 250 extant and fossil mammalian species and their antecedents over a period of 220 million years. These traits are generally expressed as co-linear gradients along the body axis rather than as distinct segmental identities. Relative position or occurrence sequence vary independently and are subject to polarity reversal and mirroring. Five major gradient modification sets are identified: (1)–quantitative changes of primary segmental identity pattern that appeared at the origin of the tetrapods ; (2)–frame shift relation of costal and vertebral identity which diversifies from the time of amniote origins; (3)–duplication, mirroring, splitting and diversification of the neomorphic laminar process first commencing at the dawn of mammals; (4)–emergence of homologically variable lumbar lateral processes upon commencement of the radiation of therian mammals and ; (5)–inflexions and transpositions of the relative position of the horizontal septum of the body and the neuraxis at the emergence of various orders of therian mammals. Convergent functional changes under homeotic control include laminar articular engagement with septo-neural transposition and ventrally arrayed lumbar transverse process support systems. Conclusion/Significance Clusters of homeotic transformations mark the emergence point of mammals in the Triassic and the radiation of therians in the Cretaceous. A cluster of homeotic changes in the Miocene hominoid Morotopithecus that are still seen in humans supports establishment of a new “hominiform” clade and suggests a homeotic origin for the human upright body plan. PMID:17925867

The Impact of Strain Reversal on Microstructure Evolution and Orientation Relationships in Ti-6Al-4V with an Initial Alpha Colony Microstructure

NASA Astrophysics Data System (ADS)

Muszka, K.; Lopez-Pedrosa, M.; Raszka, K.; Thomas, M.; Rainforth, W. M.; Wynne, B. P.

2014-12-01

The effect of forward and reverse torsion on flow behavior and microstructure evolution, particularly dynamic and static spheroidization, on Ti-6Al-4V with an alpha lamella colony microstructure was studied. Testing was undertaken sub beta transus [1088 K (815 °C)] at strain rates of either 0.05 or 0.5 s-1. Quantitative metallography and electron back scatter diffraction has identified that a critical monotonic strain ( ɛ c) in the range of 0.3 to 0.6 is required to initiate rapid dynamic spheroidization of the alpha lamella. For material deformed to strains below ɛ c and then reversed to a zero net strain the orientation relationships between alpha colonies are close to ideal Burgers, enabling prior beta grains to be fully reconstructed. Material deformed to strains greater than ɛ c and reversed lose Burgers and no beta reconstruction is possible, suggesting ɛ c is the strain required to generate break-up of lamella. Static spheroidization is, however, sensitive to strain path around ɛ c. Annealing at 1088 K (815 °C) for 4 hours for material subjected to 0.25 forward + 0.25 forward strain produces 48 pct spheroidized grains while material with 0.25 forward + 0.25 reverse strain has 10 pct spheroidization. This is believed to be a direct consequence of different levels of the stored energy between these two strain paths.

78 FR 3363 - Airworthiness Directives; the Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

...-mechanical brake flex shaft (short flexshaft) of the thrust reverser actuation system (TRAS). This proposed... the electro-mechanical brake and center drive unit (CDU) cone brake to verify the holding torque, and... describes a functional test of the electro-mechanical brake and CDU cone brake to verify the holding torque...

Bringing Science Research into Secondary Schools

ERIC Educational Resources Information Center

Allwood, Dan A.; Dean, Julian; Bryan, Matthew T.; Baker, Alan

2009-01-01

Finite element modelling software has been used to allow secondary school students to study nanoscale magnetic materials for hard drive recording applications. The students were introduced to the basic concepts of finite element modelling using a freely available internet game before modelling the magnetization reversal of single magnetic grains.…

Energy and Global Ethics.

ERIC Educational Resources Information Center

Reader, Mark

1979-01-01

Author believes that the nuclear fuel cycle is damaging to our health, physical system, ecosystem, and social system. He recommends reversing the trend toward nuclear power and solving the energy crisis by creating a global society able to live in balance with its physical environment. Journal available from 7 Harwood Drive, Amherst, New York…

Reversible emission evolution from Ag activated zeolite Na-A upon dehydration/hydration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Hui, E-mail: linh8112@163.com, E-mail: fujii@eedept.kobe-u.ac.jp; Imakita, Kenji; Fujii, Minoru, E-mail: linh8112@163.com, E-mail: fujii@eedept.kobe-u.ac.jp

2014-11-24

Reversible emission evolution of thermally treated Ag activated zeolite Na-A upon dehydration/hydration in vacuum/water vapor was observed. The phenomenon was observed even for the sample with low Ag{sup +}-Na{sup +} exchanging (8.3%), indicating that the emission from Ag activated zeolites may not come from Ag clusters while from the surrounding coordinated Ag{sup +} ions or Ag{sup 0} atoms. It was disclosed that the characteristic yellow-green emission at ∼560 ± 15 nm is strongly associated with the coordinating water molecules to the Ag{sup +} ions or Ag{sup 0} atoms, which is clear evidence for that the efficient emission from Ag activated zeolites may notmore » originate from the quantum confinement effect.« less

Multidrug evolutionary strategies to reverse antibiotic resistance

PubMed Central

Baym, Michael; Stone, Laura K.; Kishony, Roy

2017-01-01

Antibiotic treatment has two conflicting effects: the desired, immediate effect of inhibiting bacterial growth and the undesired, long-term effect of promoting the evolution of resistance. Although these contrasting outcomes seem inextricably linked, recent work has revealed several ways by which antibiotics can be combined to inhibit bacterial growth while, counterintuitively, selecting against resistant mutants. Decoupling treatment efficacy from the risk of resistance can be achieved by exploiting specific interactions between drugs, and the ways in which resistance mutations to a given drug can modulate these interactions or increase the sensitivity of the bacteria to other compounds. Although their practical application requires much further development and validation, and relies on advances in genomic diagnostics, these discoveries suggest novel paradigms that may restrict or even reverse the evolution of resistance. PMID:26722002

Suppressing relaxation in superconducting qubits by quasiparticle pumping.

PubMed

Gustavsson, Simon; Yan, Fei; Catelani, Gianluigi; Bylander, Jonas; Kamal, Archana; Birenbaum, Jeffrey; Hover, David; Rosenberg, Danna; Samach, Gabriel; Sears, Adam P; Weber, Steven J; Yoder, Jonilyn L; Clarke, John; Kerman, Andrew J; Yoshihara, Fumiki; Nakamura, Yasunobu; Orlando, Terry P; Oliver, William D

2016-12-23

Dynamical error suppression techniques are commonly used to improve coherence in quantum systems. They reduce dephasing errors by applying control pulses designed to reverse erroneous coherent evolution driven by environmental noise. However, such methods cannot correct for irreversible processes such as energy relaxation. We investigate a complementary, stochastic approach to reducing errors: Instead of deterministically reversing the unwanted qubit evolution, we use control pulses to shape the noise environment dynamically. In the context of superconducting qubits, we implement a pumping sequence to reduce the number of unpaired electrons (quasiparticles) in close proximity to the device. A 70% reduction in the quasiparticle density results in a threefold enhancement in qubit relaxation times and a comparable reduction in coherence variability. Copyright © 2016, American Association for the Advancement of Science.

Terminal Model Of Newtonian Dynamics

NASA Technical Reports Server (NTRS)

Zak, Michail

1994-01-01

Paper presents study of theory of Newtonian dynamics of terminal attractors and repellers, focusing on issues of reversibility vs. irreversibility and deterministic evolution vs. probabilistic or chaotic evolution of dynamic systems. Theory developed called "terminal dynamics" emphasizes difference between it and classical Newtonian dynamics. Also holds promise for explaining irreversibility, unpredictability, probabilistic behavior, and chaos in turbulent flows, in thermodynamic phenomena, and in other dynamic phenomena and systems.

Simulation of parameters of hydraulic drive with volumetric type controller

NASA Astrophysics Data System (ADS)

Mulyukin, V. L.; Boldyrev, A. V.; Karelin, D. L.; Belousov, A. M.

2017-09-01

The article presents a mathematical model of volumetric type hydraulic drive controller that allows to calculate the parameters of forward and reverse motion. According to the results of simulation static characteristics of rod’s speed and the force of the hydraulic cylinder rod were built and the influence of the angle of swash plate of the controller at the characteristics profile is shown. The results analysis showed that the proposed controller allows steplessly adjust the speed□ц of hydraulic cylinder’s rod motion and the force developed on the rod without the use of flow throttling.

Dynamic Convergent Evolution Drives the Passage Adaptation across 48 Years' History of H3N2 Influenza Evolution.

PubMed

Chen, Hui; Deng, Qiang; Ng, Sock Hoon; Lee, Raphael Tze Chuen; Maurer-Stroh, Sebastian; Zhai, Weiwei

2016-12-01

Influenza viruses are often propagated in a diverse set of culturing media and additional substitutions known as passage adaptation can cause extra evolution in the target strain, leading to ineffective vaccines. Using 25,482 H3N2 HA1 sequences curated from Global Initiative on Sharing All Influenza Data and National Center for Biotechnology Information databases, we found that passage adaptation is a very dynamic process that changes over time and evolves in a seesaw like pattern. After crossing the species boundary from bird to human in 1968, the influenza H3N2 virus evolves to be better adapted to the human environment and passaging them in embryonated eggs (i.e., an avian environment) leads to increasingly stronger positive selection. On the contrary, passage adaptation to the mammalian cell lines changes from positive selection to negative selection. Using two statistical tests, we identified 19 codon positions around the receptor binding domain strongly contributing to passage adaptation in the embryonated egg. These sites show strong convergent evolution and overlap extensively with positively selected sites identified in humans, suggesting that passage adaptation can confound many of the earlier studies on influenza evolution. Interestingly, passage adaptation in recent years seems to target a few codon positions in antigenic surface epitopes, which makes it difficult to produce antigenically unaltered vaccines using embryonic eggs. Our study outlines another interesting scenario whereby both convergent and adaptive evolution are working in synchrony driving viral adaptation. Future studies from sequence analysis to vaccine production need to take careful consideration of passage adaptation. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Simulating the Coronal Evolution of AR 11437 Using SDO/HMI Magnetograms

NASA Astrophysics Data System (ADS)

Yardley, Stephanie L.; Mackay, Duncan H.; Green, Lucie M.

2018-01-01

The coronal magnetic field evolution of AR 11437 is simulated by applying the magnetofrictional relaxation technique of Mackay et al. A sequence of photospheric line-of-sight magnetograms produced by the Solar Dynamics Observatory (SDO)/Helioseismic Magnetic Imager (HMI) is used to drive the simulation and continuously evolve the coronal magnetic field of the active region through a series of nonlinear force-free equilibria. The simulation is started during the first stages of the active region emergence so that its full evolution from emergence to decay can be simulated. A comparison of the simulation results with SDO/Atmospheric Imaging Assembly (AIA) observations show that many aspects of the active region’s observed coronal evolution are reproduced. In particular, it shows the presence of a flux rope, which forms at the same location as sheared coronal loops in the observations. The observations show that eruptions occurred on 2012 March 17 at 05:09 UT and 10:45 UT and on 2012 March 20 at 14:31 UT. The simulation reproduces the first and third eruption, with the simulated flux rope erupting roughly 1 and 10 hr before the observed ejections, respectively. A parameter study is conducted where the boundary and initial conditions are varied along with the physical effects of Ohmic diffusion, hyperdiffusion, and an additional injection of helicity. When comparing the simulations, the evolution of the magnetic field, free magnetic energy, relative helicity and flux rope eruption timings do not change significantly. This indicates that the key element in reproducing the coronal evolution of AR 11437 is the use of line-of-sight magnetograms to drive the evolution of the coronal magnetic field.

The modern instrumentation used for monitoring and controlling the main parameters of the regenerative electro-mechano-hydraulic drive systems

NASA Astrophysics Data System (ADS)

Cristescu, Corneliu; Drumea, Petrin; Krevey, Petrica

2009-01-01

In this work is presented the modern instrumentation used for monitoring and controlling the main parameters for one regenerative drive system, used to recovering the kinetic energy of motor vehicles, lost in the braking phase, storing and using this energy in the starting or accelerating phases. Is presented a Romanian technical solution for a regenerative driving system, based on a hybrid solution containing a hydro-mechanic module and an existing thermal motor drive, all conceived as a mechatronics system. In order to monitoring and controlling the evolution of the main parameters, the system contains a series of sensors and transducers that provide the moment, rotation, temperature, flow and pressure values. The main sensors and transducers of the regenerative drive system, their principal features and tehnical conecting solutions are presented in this paper, both with the menaging electronic and informational subsystems.

Development of nano/sub-micron grain structures in metastable austenitic stainless steels

NASA Astrophysics Data System (ADS)

Rajasekhara, Shreyas

2007-12-01

This dissertation is a part of a collaborative work between the University of Texas, Austin-Texas, the University of Oulu, Oulu-Finland, and Outokumpu Stainless Oy, Tornio-Finland, to develop commercial austenitic stainless steels with high strength and ductility. The idea behind this work involves cold-rolling a commercial metastable austenitic stainless steel - AISI 301LN stainless steel to produce strain-induced martensite, followed by an annealing treatment to generate nano/sub-micron grained austenite. AISI 301LN stainless steel sheets are cold-rolled to 63% reduction and subsequently annealed at 600°C, 700°C, 800°C, 900°C and 1000°C for 1, 10 and 100 seconds. The samples are analyzed by X-Ray diffraction, SQUID, transmission electron microscopy, and tensile testing to fundamentally understand the microstructural evolution, the mechanism for the martensite → austenite reversion, the formation of nano/sub-micron austenite grains, and the relationship between the microstructure and the strength obtained in this stainless steel. The results show that cold-rolled AISI 301LN stainless steel consist of dislocation-cell martensite, heavily deformed lath-martensite and austenite shear bands. Subsequent annealing at 600°C for short durations of 1 and 10 seconds leads to negligible martensite to austenite reversion. These 600°C samples exhibit a similar microstructure to the cold-rolled sample. However, for samples annealed at 600°C for 100 seconds and those annealed at higher temperatures (700°C, 800°C, 900°C and 1000°C) exhibit equiaxed austenitic grains of sizes 0.2mum-10mum and secondary phase precipitates. The microstructural analysis also reveals that the martensite → austenite reversion occurs via a diffusion-type reversion mechanism. In this regard, a generalized form of Avrami's equation is used to model the kinetics of martensite → austenite phase reversion. The results from the model agree reasonably well with the experiments. Furthermore, the activation energy for grain growth in nano/sub-micron grained AISI 301LN stainless steel is found to be ˜ 205kJ/mol, which is comparable to values observed in coarse grained commercial stainless steels (AISI 304, 316). However, the driving force for grain growth in nano/sub-micron grained AISI 301LN stainless steel is considerably higher when compared to other stainless steels. Finally, the average grain sizes in AISI 301LN stainless steels are related to the mechanical properties obtained, through the Hall-Petch relationship.

Discharging dynamics in an electrolytic cell

NASA Astrophysics Data System (ADS)

Feicht, Sarah E.; Frankel, Alexandra E.; Khair, Aditya S.

2016-07-01

We analyze the dynamics of a discharging electrolytic cell comprised of a binary symmetric electrolyte between two planar, parallel blocking electrodes. When a voltage is initially applied, ions in the electrolyte migrate towards the electrodes, forming electrical double layers. After the system reaches steady state and the external current decays to zero, the applied voltage is switched off and the cell discharges, with the ions eventually returning to a uniform spatial concentration. At voltages on the order of the thermal voltage VT=kBT /q ≃25 mV, where kB is Boltzmann's constant, T is temperature, and q is the charge of a proton, experiments on surfactant-doped nonpolar fluids observe that the temporal evolution of the external current during charging and discharging is not symmetric [V. Novotny and M. A. Hopper, J. Electrochem. Soc. 126, 925 (1979), 10.1149/1.2129195; P. Kornilovitch and Y. Jeon, J. Appl. Phys. 109, 064509 (2011), 10.1063/1.3554445]. In fact, at sufficiently large voltages (several VT), the current during discharging is no longer monotonic: it displays a "reverse peak" before decaying in magnitude to zero. We analyze the dynamics of discharging by solving the Poisson-Nernst-Planck equations governing ion transport via asymptotic and numerical techniques in three regimes. First, in the "linear regime" when the applied voltage V is formally much less than VT, the charging and discharging currents are antisymmetric in time; however, the potential and charge density profiles during charging and discharging are asymmetric. The current evolution is on the R C timescale of the cell, λDL /D , where L is the width of the cell, D is the diffusivity of ions, and λD is the Debye length. Second, in the (experimentally relevant) thin-double-layer limit ɛ =λD/L ≪1 , there is a "weakly nonlinear" regime defined by VT≲V ≲VTln(1 /ɛ ) , where the bulk salt concentration is uniform; thus the R C timescale of the evolution of the current magnitude persists. However, nonlinear, voltage-dependent, capacitance of the double layer is responsible for a break in temporal antisymmetry of the charging and discharging currents. Third, the reverse peak in the discharging current develops in a "strongly nonlinear" regime V ≳VTln(1 /ɛ ) , driven by neutral salt adsorption into the double layers and consequent bulk depletion during charging. The strongly nonlinear regime features current evolution over three timescales. The current decays in magnitude on the double layer relaxation timescale, λD2/D ; then grows exponentially in time towards the reverse peak on the diffusion timescale, L2/D , indicating that the reverse peak is the results of fast diffusion of ions from the double layer layer to the bulk. Following the reverse peak, the current decays exponentially to zero on the R C timescale. Notably, the current at the reverse peak and the time of the reverse peak saturate at large voltages V ≫VTln(1 /ɛ ) . We provide semi-analytic expressions for the saturated reverse peak time and current, which can be used to infer charge carrier diffusivity and concentration from experiments.

Transmission with a first-stage hydrostatic mode and two hydromechanical stages

DOEpatents

Orshansky, Jr., deceased, Elias; Weseloh, William E.

1979-01-01

A power transmission having two planetary assemblies, each having at least one carrier with planet gears, at least one sun gear, and at least one ring gear. A speed-varying module is connected in driving relation to the input shaft and in driving relationship to the sun gear or gears of the first planetary assembly. The speed-varying means may comprise a pair of hydraulic units hydraulically interconnected so that one serves as a pump while the other serves as a motor and vice versa, one of the units having a variable stroke and being connected in driving relation to the input shaft, the other unit, which may have a fixed stroke, being connected in driving relation to the sun gear. The input shaft is also connectable by a first clutch to a carrier of the first planetary assembly and by a second clutch to a sun gear of the second planetary assembly. A brake grounds the first carrier in the first range and in reverse and causes drive to be delivered to the output through a ring gear of the first planetary assembly in a hydrostatic mode. The carrier of the second planetary assembly being connected in driving relationship to that ring gear, and in all ranges these two elements transmit the drive to the output shaft.

Response of the surface tropical Atlantic Ocean to wind forcing

NASA Astrophysics Data System (ADS)

Castellanos, Paola; Pelegrí, Josep L.; Campos, Edmo J. D.; Rosell-Fieschi, Miquel; Gasser, Marc

2015-05-01

We use 10 years of satellite data (sea level pressure, surface winds and absolute dynamic topography [ADT]) together with Argo-inferred monthly-mean values of near-surface velocity and water transport, to examine how the tropical system of near-surface zonal currents responds to wind forcing. The data is analyzed using complex Hilbert empirical orthogonal functions, confirming that most of the variance has annual periodicity, with maximum amplitudes in the region spanned by the seasonal displacement of the Inter-Tropical Convergence Zone (ITCZ). The ADT mirrors the shape of the upper isopycnals, hence becoming a good indicator of the amount of water stored in the upper ocean. Within about 3° from the Equator, where the Coriolis force is small, there is year-long meridional Ekman-transport divergence that would lead to the eastward transport of the Equatorial Undercurrent and its northern and southern branches. Beyond 3° of latitude, and at least as far as 20°, the convergence of the Ekman transport generally causes a poleward positive ADT gradient, which sustains the westward South Equatorial Current (SEC). The sole exception occurs in summer, between 8°N and 12°N, when an Ekman-transport divergence develops and depletes de amount of surface water, resulting in an ADT ridge-valley system which reverses the ADT gradient and drives the eastward North Equatorial Countercurrent (NECC) at latitudes 4-9°N; in late fall, divergence ceases and the NECC drains the ADT ridge, so the ADT gradient again becomes positive and the SEC reappears. The seasonal evolution of a tilted ITCZ controls the surface water fluxes: the wind-induced transports set the surface divergence-convergence, which then drive the ADT and, through the ADT gradients, create the geostrophic jets that close the water balance.

Mechanisms of Laser-Induced Dissection and Transport of Histologic Specimens

PubMed Central

Vogel, Alfred; Lorenz, Kathrin; Horneffer, Verena; Hüttmann, Gereon; von Smolinski, Dorthe; Gebert, Andreas

2007-01-01

Rapid contact- and contamination-free procurement of histologic material for proteomic and genomic analysis can be achieved by laser microdissection of the sample of interest followed by laser-induced transport (laser pressure catapulting). The dynamics of laser microdissection and laser pressure catapulting of histologic samples of 80 μm diameter was investigated by means of time-resolved photography. The working mechanism of microdissection was found to be plasma-mediated ablation initiated by linear absorption. Catapulting was driven by plasma formation when tightly focused pulses were used, and by photothermal ablation at the bottom of the sample when defocused pulses producing laser spot diameters larger than 35 μm were used. With focused pulses, driving pressures of several hundred MPa accelerated the specimen to initial velocities of 100–300 m/s before they were rapidly slowed down by air friction. When the laser spot was increased to a size comparable to or larger than the sample diameter, both driving pressure and flight velocity decreased considerably. Based on a characterization of the thermal and optical properties of the histologic specimens and supporting materials used, we calculated the evolution of the heat distribution in the sample. Selected catapulted samples were examined by scanning electron microscopy or analyzed by real-time reverse-transcriptase polymerase chain reaction. We found that catapulting of dissected samples results in little collateral damage when the laser pulses are either tightly focused or when the laser spot size is comparable to the specimen size. By contrast, moderate defocusing with spot sizes up to one-third of the specimen diameter may involve significant heat and ultraviolet exposure. Potential side effects are maximal when samples are catapulted directly from a glass slide without a supporting polymer foil. PMID:17766336

Reverse engineering physical models employing a sensor integration between 3D stereo detection and contact digitization

NASA Astrophysics Data System (ADS)

Chen, Liang-Chia; Lin, Grier C. I.

1997-12-01

A vision-drive automatic digitization process for free-form surface reconstruction has been developed, with a coordinate measurement machine (CMM) equipped with a touch-triggered probe and a CCD camera, in reverse engineering physical models. The process integrates 3D stereo detection, data filtering, Delaunay triangulation, adaptive surface digitization into a single process of surface reconstruction. By using this innovative approach, surface reconstruction can be implemented automatically and accurately. Least-squares B- spline surface models with the controlled accuracy of digitization can be generated for further application in product design and manufacturing processes. One industrial application indicates that this approach is feasible, and the processing time required in reverse engineering process can be significantly reduced up to more than 85%.

Acceleration of Convergence to Equilibrium in Markov Chains by Breaking Detailed Balance

NASA Astrophysics Data System (ADS)

Kaiser, Marcus; Jack, Robert L.; Zimmer, Johannes

2017-07-01

We analyse and interpret the effects of breaking detailed balance on the convergence to equilibrium of conservative interacting particle systems and their hydrodynamic scaling limits. For finite systems of interacting particles, we review existing results showing that irreversible processes converge faster to their steady state than reversible ones. We show how this behaviour appears in the hydrodynamic limit of such processes, as described by macroscopic fluctuation theory, and we provide a quantitative expression for the acceleration of convergence in this setting. We give a geometrical interpretation of this acceleration, in terms of currents that are antisymmetric under time-reversal and orthogonal to the free energy gradient, which act to drive the system away from states where (reversible) gradient-descent dynamics result in slow convergence to equilibrium.

Extreme-volatility dynamics in crude oil markets

NASA Astrophysics Data System (ADS)

Jiang, Xiong-Fei; Zheng, Bo; Qiu, Tian; Ren, Fei

2017-02-01

Based on concepts and methods from statistical physics, we investigate extreme-volatility dynamics in the crude oil markets, using the high-frequency data from 2006 to 2010 and the daily data from 1986 to 2016. The dynamic relaxation of extreme volatilities is described by a power law, whose exponents usually depend on the magnitude of extreme volatilities. In particular, the relaxation before and after extreme volatilities is time-reversal symmetric at the high-frequency time scale, but time-reversal asymmetric at the daily time scale. This time-reversal asymmetry is mainly induced by exogenous events. However, the dynamic relaxation after exogenous events exhibits the same characteristics as that after endogenous events. An interacting herding model both with and without exogenous driving forces could qualitatively describe the extreme-volatility dynamics.

Photonic microwave waveforms generation based on pulse carving and superposition in time-domain

NASA Astrophysics Data System (ADS)

Xia, Yi; Jiang, Yang; Zi, Yuejiao; He, Yutong; Tian, Jing; Zhang, Xiaoyu; Luo, Hao; Dong, Ruyang

2018-05-01

A novel photonic approach for various microwave waveforms generation based on time-domain synthesis is theoretically analyzed and experimentally investigated. In this scheme, two single-drive Mach-Zehnder modulators are used for pulses shaping. After shifting the phase and implementing envelopes superposition of the pulses, desired waveforms can be achieved in time-domain. The theoretic analysis and simulations are presented. In the experimental demonstrations, a triangular waveform, square waveform, and half duty cycle sawtooth (or reversed-sawtooth) waveform are generated successfully. By utilizing time multiplexing technique, a frequency-doubled sawtooth (or reversed-sawtooth) waveform with 100% duty cycle can be obtained. In addition, a fundamental frequency sawtooth (or reversed-sawtooth) waveform with 100% duty cycle can also be achieved by the superposition of square waveform and frequency-doubled sawtooth waveform.

Position measurement of the direct drive motor of Large Aperture Telescope

NASA Astrophysics Data System (ADS)

Li, Ying; Wang, Daxing

2010-07-01

Along with the development of space and astronomy science, production of large aperture telescope and super large aperture telescope will definitely become the trend. It's one of methods to solve precise drive of large aperture telescope using direct drive technology unified designed of electricity and magnetism structure. A direct drive precise rotary table with diameter of 2.5 meters researched and produced by us is a typical mechanical & electrical integration design. This paper mainly introduces position measurement control system of direct drive motor. In design of this motor, position measurement control system requires having high resolution, and precisely aligning the position of rotor shaft and making measurement, meanwhile transferring position information to position reversing information corresponding to needed motor pole number. This system has chosen high precision metal band coder and absolute type coder, processing information of coders, and has sent 32-bit RISC CPU making software processing, and gained high resolution composite coder. The paper gives relevant laboratory test results at the end, indicating the position measurement can apply to large aperture telescope control system. This project is subsidized by Chinese National Natural Science Funds (10833004).

Running with the Red Queen: the role of biotic conflicts in evolution

PubMed Central

Brockhurst, Michael A.; Chapman, Tracey; King, Kayla C.; Mank, Judith E.; Paterson, Steve; Hurst, Gregory D. D.

2014-01-01

What are the causes of natural selection? Over 40 years ago, Van Valen proposed the Red Queen hypothesis, which emphasized the primacy of biotic conflict over abiotic forces in driving selection. Species must continually evolve to survive in the face of their evolving enemies, yet on average their fitness remains unchanged. We define three modes of Red Queen coevolution to unify both fluctuating and directional selection within the Red Queen framework. Empirical evidence from natural interspecific antagonisms provides support for each of these modes of coevolution and suggests that they often operate simultaneously. We argue that understanding the evolutionary forces associated with interspecific interactions requires incorporation of a community framework, in which new interactions occur frequently. During their early phases, these newly established interactions are likely to drive fast evolution of both parties. We further argue that a more complete synthesis of Red Queen forces requires incorporation of the evolutionary conflicts within species that arise from sexual reproduction. Reciprocally, taking the Red Queen's perspective advances our understanding of the evolution of these intraspecific conflicts. PMID:25355473

Selection for Social Signalling Drives the Evolution of Chameleon Colour Change

PubMed Central

Stuart-Fox, Devi; Moussalli, Adnan

2008-01-01

Rapid colour change is a remarkable natural phenomenon that has evolved in several vertebrate and invertebrate lineages. The two principal explanations for the evolution of this adaptive strategy are (1) natural selection for crypsis (camouflage) against a range of different backgrounds and (2) selection for conspicuous social signals that maximise detectability to conspecifics, yet minimise exposure to predators because they are only briefly displayed. Here we show that evolutionary shifts in capacity for colour change in southern African dwarf chameleons (Bradypodion spp.) are associated with increasingly conspicuous signals used in male contests and courtship. To the chameleon visual system, species showing the most dramatic colour change display social signals that contrast most against the environmental background and amongst adjacent body regions. We found no evidence for the crypsis hypothesis, a finding reinforced by visual models of how both chameleons and their avian predators perceive chameleon colour variation. Instead, our results suggest that selection for conspicuous social signals drives the evolution of colour change in this system, supporting the view that transitory display traits should be under strong selection for signal detectability. PMID:18232740

Signal design and perception in Hypocnemis antbirds: evidence for convergent evolution via social selection.

PubMed

Tobias, Joseph A; Seddon, Nathalie

2009-12-01

Natural selection is known to produce convergent phenotypes through mimicry or ecological adaptation. It has also been proposed that social selection--i.e., selection exerted by social competition--may drive convergent evolution in signals mediating interspecific communication, yet this idea remains controversial. Here, we use color spectrophotometry, acoustic analyses, and playback experiments to assess the hypothesis of adaptive signal convergence in two competing nonsister taxa, Hypocnemis peruviana and H. subflava (Aves: Thamnophilidae). We show that the structure of territorial songs in males overlaps in sympatry, with some evidence of convergent character displacement. Conversely, nonterritorial vocal and visual signals in males are strikingly diagnostic, in line with 6.8% divergence in mtDNA sequences. The same pattern of variation applies to females. Finally, we show that songs in both sexes elicit strong territorial responses within and between species, whereas songs of a third, allopatric and more closely related species (H. striata) are structurally divergent and elicit weaker responses. Taken together, our results provide compelling evidence that social selection can act across species boundaries to drive convergent or parallel evolution in taxa competing for space and resources.

Defensive traits exhibit an evolutionary trade-off and drive diversification in ants.

PubMed

Blanchard, Benjamin D; Moreau, Corrie S

2017-02-01

Evolutionary biologists have long predicted that evolutionary trade-offs among traits should constrain morphological divergence and species diversification. However, this prediction has yet to be tested in a broad evolutionary context in many diverse clades, including ants. Here, we reconstruct an expanded ant phylogeny representing 82% of ant genera, compile a new family-wide trait database, and conduct various trait-based analyses to show that defensive traits in ants do exhibit an evolutionary trade-off. In particular, the use of a functional sting negatively correlates with a suite of other defensive traits including spines, large eye size, and large colony size. Furthermore, we find that several of the defensive traits that trade off with a sting are also positively correlated with each other and drive increased diversification, further suggesting that these traits form a defensive suite. Our results support the hypothesis that trade-offs in defensive traits significantly constrain trait evolution and influence species diversification in ants. © 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution.

The role of thermal vapor diffusion in the subsurface hydrologic evolution of Mars

NASA Technical Reports Server (NTRS)

Clifford, Stephen M.

1991-01-01

The hydrologic response of groundwater to the thermal evolution of the early martian crust is considered. When a temperature gradient is present in a moist porous medium, it gives rise to a vapor-pressure gradient that drives the diffusion of water vapor from regions of high to low temperature. By this process, a geothermal gradient as small as 15 K/km could drive the vertical transport of 1 km of water to the freezing front at the base of the martian crysophere every 10 exp 6-10 exp 7 years, or the equivalent of about 100-1000 km of water over the course of martian geologic history. Models of the thermal history of Mars suggest that this thermally-driven vapor flux may have been as much as 3-5 times greater in the past. The magnitude of this transport suggests that the process of geothermally-induced vapor diffusion may have played a critical role in the initial emplacement of ground ice and the subsequent geomorphic and geochemical evolution of the martian crust.

An arms race between producers and scroungers can drive the evolution of social cognition

PubMed Central

2014-01-01

The “social intelligence hypothesis” states that the need to cope with complexities of social life has driven the evolution of advanced cognitive abilities. It is usually invoked in the context of challenges arising from complex intragroup structures, hierarchies, and alliances. However, a fundamental aspect of group living remains largely unexplored as a driving force in cognitive evolution: the competition between individuals searching for resources (producers) and conspecifics that parasitize their findings (scroungers). In populations of social foragers, abilities that enable scroungers to steal by outsmarting producers, and those allowing producers to prevent theft by outsmarting scroungers, are likely to be beneficial and may fuel a cognitive arms race. Using analytical theory and agent-based simulations, we present a general model for such a race that is driven by the producer–scrounger game and show that the race’s plausibility is dramatically affected by the nature of the evolving abilities. If scrounging and scrounging avoidance rely on separate, strategy-specific cognitive abilities, arms races are short-lived and have a limited effect on cognition. However, general cognitive abilities that facilitate both scrounging and scrounging avoidance undergo stable, long-lasting arms races. Thus, ubiquitous foraging interactions may lead to the evolution of general cognitive abilities in social animals, without the requirement of complex intragroup structures. PMID:24822021

Virus Satellites Drive Viral Evolution and Ecology

PubMed Central

Frígols, Belén; Quiles-Puchalt, Nuria; Mir-Sanchis, Ignacio; Donderis, Jorge; Elena, Santiago F.; Buckling, Angus; Novick, Richard P.; Marina, Alberto; Penadés, José R.

2015-01-01

Virus satellites are widespread subcellular entities, present both in eukaryotic and in prokaryotic cells. Their modus vivendi involves parasitism of the life cycle of their inducing helper viruses, which assures their transmission to a new host. However, the evolutionary and ecological implications of satellites on helper viruses remain unclear. Here, using staphylococcal pathogenicity islands (SaPIs) as a model of virus satellites, we experimentally show that helper viruses rapidly evolve resistance to their virus satellites, preventing SaPI proliferation, and SaPIs in turn can readily evolve to overcome phage resistance. Genomic analyses of both these experimentally evolved strains as well as naturally occurring bacteriophages suggest that the SaPIs drive the coexistence of multiple alleles of the phage-coded SaPI inducing genes, as well as sometimes selecting for the absence of the SaPI depressing genes. We report similar (accidental) evolution of resistance to SaPIs in laboratory phages used for Staphylococcus aureus typing and also obtain the same qualitative results in both experimental evolution and phylogenetic studies of Enterococcus faecalis phages and their satellites viruses. In summary, our results suggest that helper and satellite viruses undergo rapid coevolution, which is likely to play a key role in the evolution and ecology of the viruses as well as their prokaryotic hosts. PMID:26495848

Evolution of divergent female mating preference in response to experimental sexual selection.

PubMed

Debelle, Allan; Ritchie, Michael G; Snook, Rhonda R

2014-09-01

Sexual selection is predicted to drive the coevolution of mating signals and preferences (mating traits) within populations, and could play a role in speciation if sexual isolation arises due to mating trait divergence between populations. However, few studies have demonstrated that differences in mating traits between populations result from sexual selection alone. Experimental evolution is a promising approach to directly examine the action of sexual selection on mating trait divergence among populations. We manipulated the opportunity for sexual selection (low vs. high) in populations of Drosophila pseudoobscura. Previous studies on these experimental populations have shown that sexual selection manipulation resulted in the divergence between sexual selection treatments of several courtship song parameters, including interpulse interval (IPI) which markedly influences male mating success. Here, we measure female preference for IPI using a playback design to test for preference divergence between the sexual selection treatments after 130 generations of experimental sexual selection. The results suggest that female preference has coevolved with male signal, in opposite directions between the sexual selection treatments, providing direct evidence of the ability of sexual selection to drive the divergent coevolution of mating traits between populations. We discuss the implications in the context sexual selection and speciation. © 2014 The Authors. Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution.

Self-Organization of Microcircuits in Networks of Spiking Neurons with Plastic Synapses.

PubMed

Ocker, Gabriel Koch; Litwin-Kumar, Ashok; Doiron, Brent

2015-08-01

The synaptic connectivity of cortical networks features an overrepresentation of certain wiring motifs compared to simple random-network models. This structure is shaped, in part, by synaptic plasticity that promotes or suppresses connections between neurons depending on their joint spiking activity. Frequently, theoretical studies focus on how feedforward inputs drive plasticity to create this network structure. We study the complementary scenario of self-organized structure in a recurrent network, with spike timing-dependent plasticity driven by spontaneous dynamics. We develop a self-consistent theory for the evolution of network structure by combining fast spiking covariance with a slow evolution of synaptic weights. Through a finite-size expansion of network dynamics we obtain a low-dimensional set of nonlinear differential equations for the evolution of two-synapse connectivity motifs. With this theory in hand, we explore how the form of the plasticity rule drives the evolution of microcircuits in cortical networks. When potentiation and depression are in approximate balance, synaptic dynamics depend on weighted divergent, convergent, and chain motifs. For additive, Hebbian STDP these motif interactions create instabilities in synaptic dynamics that either promote or suppress the initial network structure. Our work provides a consistent theoretical framework for studying how spiking activity in recurrent networks interacts with synaptic plasticity to determine network structure.

Cannibals in space: the coevolution of cannibalism and dispersal in spatially structured populations.

PubMed

Rudolf, Volker H W; Kamo, Masashi; Boots, Mike

2010-05-01

The propensity for cannibalism varies considerably both within and between species. Currently we have little understanding of both the causes of this variation and its evolutionary consequences for other life-history traits. We examine how different levels of spatial structure affect the evolution of cannibalism and how cannibalism in turn drives the evolution of dispersal. Using pair approximations and simulations, we show that cannibalism can easily evolve in spatially structured populations as long as some dispersal exists. Furthermore, for a wide range of intermediate levels of spatial structure, we find the possibility of evolutionary branching leading to polymorphism in cannibalism. We also show that cannibalism itself can have important evolutionary consequences and select for increased dispersal rates, thus helping to determine the spatial structure of populations. The coevolution of cannibalism and dispersal results in the evolution of various alternative life-history strategies with different dispersal and cannibalism regimes. Which strategy evolves depends on the environmental conditions that determine initial cannibalism rates. Our results therefore suggest that differences in spatial structure could explain variation in the propensity for cannibalism and cannibalistic polyphenism. Furthermore, results emphasize that cannibalism can drive the evolution of other life-history traits and determine the spatial structure of natural populations.

Self-Organization of Microcircuits in Networks of Spiking Neurons with Plastic Synapses

PubMed Central

Ocker, Gabriel Koch; Litwin-Kumar, Ashok; Doiron, Brent

2015-01-01

The synaptic connectivity of cortical networks features an overrepresentation of certain wiring motifs compared to simple random-network models. This structure is shaped, in part, by synaptic plasticity that promotes or suppresses connections between neurons depending on their joint spiking activity. Frequently, theoretical studies focus on how feedforward inputs drive plasticity to create this network structure. We study the complementary scenario of self-organized structure in a recurrent network, with spike timing-dependent plasticity driven by spontaneous dynamics. We develop a self-consistent theory for the evolution of network structure by combining fast spiking covariance with a slow evolution of synaptic weights. Through a finite-size expansion of network dynamics we obtain a low-dimensional set of nonlinear differential equations for the evolution of two-synapse connectivity motifs. With this theory in hand, we explore how the form of the plasticity rule drives the evolution of microcircuits in cortical networks. When potentiation and depression are in approximate balance, synaptic dynamics depend on weighted divergent, convergent, and chain motifs. For additive, Hebbian STDP these motif interactions create instabilities in synaptic dynamics that either promote or suppress the initial network structure. Our work provides a consistent theoretical framework for studying how spiking activity in recurrent networks interacts with synaptic plasticity to determine network structure. PMID:26291697

Convergent and divergent evolution in carnivorous pitcher plant traps.

PubMed

Thorogood, Chris J; Bauer, Ulrike; Hiscock, Simon J

2018-02-01

Contents Summary 1035 I. Introduction 1035 II. Evolution of the pitcher 1036 III. Convergent evolution 1036 IV. Divergent evolution 1038 V. Adaptive radiation and speciation 1040 VI. Conclusions and perspectives 1040 Acknowledgements 1040 References 1040 SUMMARY: The pitcher trap is a striking example of convergent evolution across unrelated carnivorous plant lineages. Convergent traits that have evolved across pitcher plant lineages are essential for trap function, suggesting that key selective pressures are in action. Recent studies have also revealed patterns of divergent evolution in functional pitcher morphology within genera. Adaptations to differences in local prey assemblages may drive such divergence and, ultimately, speciation. Here, we review recent research on convergent and divergent evolution in pitcher plant traps, with a focus on the genus Nepenthes, which we propose as a new model for research into adaptive radiation and speciation. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Quantitative assessment of driving performance in Parkinson's disease

PubMed Central

Wood, J; Worringham, C; Kerr, G; Mallon, K; Silburn, P

2005-01-01

Objectives: The primary aim of this study was to determine how Parkinson's disease (PD) affects driving performance. It also examined whether changes in driver safety were related to specific clinical disease markers or an individual's self rating of driving ability. Methods: The driving performance of 25 patients with idiopathic PD and 21 age matched controls was assessed on a standardised open road route by an occupational therapist and driving instructor, to provide overall safety ratings and specific driving error scores. Results: The drivers with PD were rated as significantly less safe (p<0.05) than controls, and more than half of the drivers with PD would not have passed a state based driving test. The driver safety ratings were more strongly related to disease duration (r = –0.60) than to their on time Unified Parkinson's Disease Rating Scale (r = –0.24). Drivers with PD made significantly more errors than the control group during manoeuvres that involved changing lanes and lane keeping, monitoring their blind spot, reversing, car parking, and traffic light controlled intersections. The driving instructor also had to intervene to avoid an incident significantly more often for drivers with PD than for controls. Interestingly, driver safety ratings were unrelated to an individual's rating of their own driving performance, and this was the case for all participants. Conclusions: As a group, drivers with PD are less safe to drive than age matched controls. Standard clinical markers cannot reliably predict driver safety. Further studies are required to ascertain whether the identified driving difficulties can be ameliorated. PMID:15654027

Dynamic ocean topography from CryoSat-2: examining recent changes in ice-ocean stress and advancing a theory for Beaufort Gyre stabilization

NASA Astrophysics Data System (ADS)

Dewey, S.; Morison, J.; Kwok, R.; Dickinson, S.; Morison, D.; Andersen, R.

2017-12-01

Model and sparse observational evidence has shown the ocean current speed in the Beaufort Gyre to have increased and recently stabilized. However, full-basin altimetric observations of dynamic ocean topography (DOT) and ocean surface currents have yet to be applied to the dynamics of gyre stabilization. DOT fields from retracked CryoSat-2 retrievals in Arctic Ocean leads have enabled us to calculate 2-month average ocean geostrophic currents. These currents are crucial to accurately computing ice-ocean stress, especially because they have accelerated so that their speed rivals that of the overlying sea ice. Given these observations, we can shift our view of the Beaufort Gyre as a system in which the wind drives the ice and the ice drives a passive ocean to a system with the following feedback: After initial input of energy by wind, ice velocity decreases due to water drag and internal ice stress and the ocean drives the ice, reversing Ekman pumping and decelerating the gyre. This reversal changes the system from a persistently convergent regime to one in which freshwater is released from the gyre and doming of the gyre decreases, without any change in long-term average wind stress curl. Through these processes, the ice-ocean stress provides a key feedback in Beaufort Gyre stabilization.

Complexation-induced supramolecular assembly drives metal-ion extraction.

PubMed

Ellis, Ross J; Meridiano, Yannick; Muller, Julie; Berthon, Laurence; Guilbaud, Philippe; Zorz, Nicole; Antonio, Mark R; Demars, Thomas; Zemb, Thomas

2014-09-26

Combining experiment with theory reveals the role of self-assembly and complexation in metal-ion transfer through the water-oil interface. The coordinating metal salt Eu(NO3)3 was extracted from water into oil by a lipophilic neutral amphiphile. Molecular dynamics simulations were coupled to experimental spectroscopic and X-ray scattering techniques to investigate how local coordination interactions between the metal ion and ligands in the organic phase combine with long-range interactions to produce spontaneous changes in the solvent microstructure. Extraction of the Eu(3+)-3(NO3(-)) ion pairs involves incorporation of the "hard" metal complex into the core of "soft" aggregates. This seeds the formation of reverse micelles that draw the water and "free" amphiphile into nanoscale hydrophilic domains. The reverse micelles interact through attractive van der Waals interactions and coalesce into rod-shaped polynuclear Eu(III) -containing aggregates with metal centers bridged by nitrate. These preorganized hydrophilic domains, containing high densities of O-donor ligands and anions, provide improved Eu(III) solvation environments that help drive interfacial transfer, as is reflected by the increasing Eu(III) partitioning ratios (oil/aqueous) despite the organic phase approaching saturation. For the first time, this multiscale approach links metal-ion coordination with nanoscale structure to reveal the free-energy balance that drives the phase transfer of neutral metal salts. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

An analysis of mobile genetic elements in three Plasmodium species and their potential impact on the nucleotide composition of the P. falciparum genome.

PubMed

Durand, Pierre M; Oelofse, Andries J; Coetzer, Theresa L

2006-11-04

The completed genome sequences of the malaria parasites P. falciparum, P. y. yoelii and P. vivax have revealed some unusual features. P. falciparum contains the most AT rich genome sequenced so far--over 90% in some regions. In comparison, P. y. yoelii is approximately 77% and P. vivax is approximately 55% AT rich. The evolutionary reasons for these findings are unknown. Mobile genetic elements have a considerable impact on genome evolution but a thorough investigation of these elements in Plasmodium has not been undertaken. We therefore performed a comprehensive genome analysis of these elements and their derivatives in the three Plasmodium species. Whole genome analysis was performed using bioinformatic methods. Forty potential protein encoding sequences with features of transposable elements were identified in P. vivax, eight in P. y. yoelii and only six in P. falciparum. Further investigation of the six open reading frames in P. falciparum revealed that only one is potentially an active mobile genetic element. Most of the open reading frames identified in all three species are hypothetical proteins. Some represent annotated host proteins such as the putative telomerase reverse transcriptase genes in P. y. yoelii and P. falciparum. One of the P. vivax open reading frames identified in this study demonstrates similarity to telomerase reverse transcriptase and we conclude it to be the orthologue of this gene. There is a divergence in the frequencies of mobile genetic elements in the three Plasmodium species investigated. Despite the limitations of whole genome analytical methods, it is tempting to speculate that mobile genetic elements might have been a driving force behind the compositional bias of the P. falciparum genome.

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

PubMed Central

Liu, Chen

2017-01-01

A functioning gene drive system could fundamentally change our strategies for the control of vector-borne diseases by facilitating rapid dissemination of transgenes that prevent pathogen transmission or reduce vector capacity. CRISPR/Cas9 gene drive promises such a mechanism, which works by converting cells that are heterozygous for the drive construct into homozygotes, thereby enabling super-Mendelian inheritance. Although CRISPR gene drive activity has already been demonstrated, a key obstacle for current systems is their propensity to generate resistance alleles, which cannot be converted to drive alleles. In this study, we developed two CRISPR gene drive constructs based on the nanos and vasa promoters that allowed us to illuminate the different mechanisms by which resistance alleles are formed in the model organism Drosophila melanogaster. We observed resistance allele formation at high rates both prior to fertilization in the germline and post-fertilization in the embryo due to maternally deposited Cas9. Assessment of drive activity in genetically diverse backgrounds further revealed substantial differences in conversion efficiency and resistance rates. Our results demonstrate that the evolution of resistance will likely impose a severe limitation to the effectiveness of current CRISPR gene drive approaches, especially when applied to diverse natural populations. PMID:28727785

Two-fluid dynamo relaxation and momentum transport induced by CHI on HIST

NASA Astrophysics Data System (ADS)

Nagata, Masayoshi; Hirono, Hidetoshi; Hanao, Takafumi; Hyobu, Takahiro; Ito, Kengo; Matsumoto, Keisuke; Nakayama, Takashi; Oki, Nobuharu; Kikuchi, Yusuke; Fukumoto, Naoyuki

2013-10-01

Non-inductive current drive by using Multi-pulsing coaxial helicity injection was studied on HIST. In the double-pulsing CHI experiment, we have examined two-fluid effects by reversing polarity of the bias poloidal coil current. In the ST magnetic configurations with the right-handed magnetic field (positive CHI), there are a diamagnetic structure in the open flux column region and a paramagnetic structure in the closed flux region. It is naturally understood that the direction of the poloidal magnetic field (toroidal current) is reversed in reversing the polarity of the bias flux from positive to negative. However, the poloidal current is surprisingly reversed in reversing the magnetic helicity polarity. The direction of the poloidal current is opposite in the each region. The toroidal flow is reversed, but a shear profile of the poloidal flow is not changed significantly. In this configuration, the diamagnetic structure appears in the closed flux region. Thus, not only Jt×Bp but also Jp×Bt force contributes on pressure balance leading to a higher beta. We are studying a more general helicity conservation that constrains the interaction between flows and magnetic fields and momentum transport in the two-fluid framework.

Theory of many-body localization in periodically driven systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abanin, Dmitry A., E-mail: dabanin@gmail.com; De Roeck, Wojciech; Huveneers, François

We present a theory of periodically driven, many-body localized (MBL) systems. We argue that MBL persists under periodic driving at high enough driving frequency: The Floquet operator (evolution operator over one driving period) can be represented as an exponential of an effective time-independent Hamiltonian, which is a sum of quasi-local terms and is itself fully MBL. We derive this result by constructing a sequence of canonical transformations to remove the time-dependence from the original Hamiltonian. When the driving evolves smoothly in time, the theory can be sharpened by estimating the probability of adiabatic Landau–Zener transitions at many-body level crossings. Inmore » all cases, we argue that there is delocalization at sufficiently low frequency. We propose a phase diagram of driven MBL systems.« less

Landau-Zener-Stückelberg-Majorana interference in a 3D transmon driven by a chirped microwave

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gong, Ming; Department of Physics and Astronomy, University of Kansas, Lawrence, Kansas 66045; Zhou, Yu

2016-03-14

By driving a 3D transmon with microwave fields, we generate an effective avoided energy-level crossing. Then we chirp microwave frequency, which is equivalent to driving the system through the avoided energy-level crossing by sweeping the avoided crossing. A double-passage chirp produces Landau-Zener-Stückelberg-Majorana (LZSM) interference that agree well with the numerical results, especially with the initial state being an eigen-energy state in the center of an avoided level crossing. A time-resolved state tomography measurement is performed in the evolution of LZSM interference, showing an experimental evidence for the dynamical evolution of quantum state. Our method is fully applicable to other quantummore » systems that contain no intrinsic avoided level crossing, providing an alternative approach for quantum control and quantum simulation.« less

Understanding the Accretion Engine in Pre-main Sequence Stars

NASA Astrophysics Data System (ADS)

Gómez de Castro, Ana I.

2009-05-01

Planetary systems are angular momentum reservoirs generated during star formation as a result of the joint action of gravity and angular momentum conservation. The accretion process drives to the generation of powerful engines able to drive the optical jets and the molecular outflows. A fraction of the engine energy is released into heating the circumstellar plasma to temperatures between 3000 K to 10 MK depending on the plasma location and density. There are very important unsolved problems concerning the nature of the engine, its evolution and its impact in the chemical evolution of the disk. Of special relevance is the understanding of the shear layer between the stellar photosphere and the disk; this layer controls a significant fraction of the magnetic field building up and the subsequent dissipative processes ought to be studied in the UV.

Domain Wall Evolution in Phase Transforming Oxides

DTIC Science & Technology

2015-01-14

configumtions under driving forces (e.g. changes in temperature and electric fields) in an effort to: 1) understand the underlying linkage between -1...configurations under driving forces (e.g. changes in temperature and electric fields) in an effort to: 1) understand the underlying linkage between...Extensive domain wall motion and deaging resistance in morphotropic 0.55Bi(Ni1/2Ti1/2)O3–0.45PbTiO3 polycrystalline ferroelectrics, Applied Physics Letters

Open problems of magnetic island control by electron cyclotron current drive

DOE PAGES

Grasso, Daniela; Lazzaro, E.; Borgogno, D.; ...

2016-11-17

This study reviews key aspects of the problem of magnetic islands control by electron cyclotron current drive in fusion devices. On the basis of the ordering of the basic spatial and time scales of the magnetic reconnection physics, we present the established results, highlighting some of the open issues posed by the small-scale structures that typically accompany the nonlinear evolution of the magnetic islands and constrain the effect of the control action.

Transverse ac-driven and geometric ratchet effects for vortices in conformal crystal pinning arrays

DOE PAGES

Reichhardt, Charles; Reichhardt, Cynthia Jane Olsen

2016-02-11

A conformal pinning array is created by taking a conformal transformation of a uniform hexagonal lattice to create a structure in which the sixfold ordering of the original lattice is preserved but which has a spatial gradient in the pinning site density. With a series of conformal arrays it is possible to create asymmetric substrates, and it was previously shown that when an ac drive is applied parallel to the asymmetry direction, a pronounced ratchet effect occurs with a net dc flow of vortices in the same direction as the ac drive. Here, in this article, we show that whenmore » the ac drive is applied perpendicular to the substrate asymmetry direction, it is possible to realize a transverse ratchet effect where a net dc flow of vortices is generated perpendicular to the ac drive. The conformal transverse ratchet effect is distinct from previous versions of transverse ratchets in that it occurs due to the generation of non-Gaussian transverse vortex velocity fluctuations by the plastic motion of vortices, so that the system behaves as a noise correlation ratchet. The transverse ratchet effect is much more pronounced in the conformal arrays than in random gradient arrays and is absent in square gradient arrays due the different nature of the vortex flow in each geometry. We show that a series of reversals can occur in the transverse ratchet effect due to changes in the vortex flow across the pinning gradient as a function of vortex filling, pinning strength, and ac amplitude. We also consider the case where a dc drive applied perpendicular to the substrate asymmetry direction generates a net flow of vortices perpendicular to the dc drive, producing what is known as a geometric or drift ratchet that again arises due to non-Gaussian dynamically generated fluctuations. The drift ratchet is more efficient than the ac driven ratchet and also exhibits a series of reversals for varied parameters. Lastly, our results should be general to a wide class of systems undergoing nonequilibrium dynamics on conformal substrates, such as colloidal particles on optical traps.« less

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.

PubMed

McGranahan, Nicholas; Swanton, Charles

2017-02-09

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that have revealed intra-tumor heterogeneity across cancer types and the dynamics, constraints, and contingencies inherent to tumor evolution. We emphasize the importance of macro-evolutionary leaps, often involving large-scale chromosomal alterations, in driving tumor evolution and metastasis and consider the role of the tumor microenvironment in engendering heterogeneity and drug resistance. We suggest that bold approaches to drug development, harnessing the adaptive properties of the immune-microenvironment while limiting those of the tumor, combined with advances in clinical trial-design, will improve patient outcome. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

Fold or hold: experimental evolution in vitro

PubMed Central

Collins, S; Rambaut, A; Bridgett, S J

2013-01-01

We introduce a system for experimental evolution consisting of populations of short oligonucleotides (Oli populations) evolving in a modified quantitative polymerase chain reaction (qPCR). It is tractable at the genetic, genomic, phenotypic and fitness levels. The Oli system uses DNA hairpins designed to form structures that self-prime under defined conditions. Selection acts on the phenotype of self-priming, after which differences in fitness are amplified and quantified using qPCR. We outline the methodological and bioinformatics tools for the Oli system here and demonstrate that it can be used as a conventional experimental evolution model system by test-driving it in an experiment investigating adaptive evolution under different rates of environmental change. PMID:24003997

Integration of ambient seismic noise monitoring, displacement and meteorological measurements to infer the temperature-controlled long-term evolution of a complex prone-to-fall cliff

NASA Astrophysics Data System (ADS)

Colombero, C.; Baillet, L.; Comina, C.; Jongmans, D.; Larose, E.; Valentin, J.; Vinciguerra, S.

2018-06-01

Monitoring the temporal evolution of resonance frequencies and velocity changes detected from ambient seismic noise recordings can help in recognizing reversible and irreversible modifications within unstable rock volumes. With this aim, the long-term ambient seismic noise data set acquired at the potentially unstable cliff of Madonna delSasso (NW Italian Alps) was analysed in this study, using both spectral analysis and cross-correlation techniques. Noise results were integrated and compared with direct displacement measurements and meteorological data, to understand the long-term evolution of the cliff. No irreversible modifications in the stability of the site were detected over the monitored period. Conversely, daily and seasonal air temperature fluctuations were found to control resonance frequency values, amplitudes and directivities and to induce reversible velocity changes within the fractured rock mass. The immediate modification in the noise parameters due to temperature fluctuations was interpreted as the result of rock mass thermal expansion and contraction, inducing variations in the contact stiffness along the fractures isolating two unstable compartments. Differences with previous case studies were highlighted in the long-term evolution of noise spectral amplitudes and directivities, due to the complex 3-D fracture setting of the site and to the combined effects of the two unstable compartments.

Protic ionic liquid modified electrocatalyst enables robust anode under cell reversal condition

NASA Astrophysics Data System (ADS)

Zhu, Zhengyu; Yan, Xiaocong; Tang, Haolin; Cai, Haopeng; Pan, Mu; Zhang, Haining; Luo, Jiangshui

2017-05-01

Pt/C has been commercially used as anode electrocatalyst for fuel cells but generally exhibits limited durability under conditions of fuel starvation and subsequent cell reversal. Herein we report an improved scaffold concept to simultaneously stabilize the catalyst against particle growth and reduce the adverse effects of cell reversal by modifying Pt/C with suitable protic ionic liquids (PILs). The modified Pt/C catalysts show enhanced cell reversal tolerance because of their high activity towards oxygen evolution reaction (OER), up to 300 mV lower overpotential compared to the unmodified Pt/C. Moreover, the PIL modified catalysts show better resistance to the loss of electrochemical surface area (ECSA) under simulated cell reversal conditions. The results indicate that modification of Pt/C catalysts with PILs is a promising strategy to enhance the stability and durability of electrocatalysts in fuel cell applications with the risk of frequent fuel starvation events, such as automotive fuel cells.

Baculovirus phylogeny and evolution.

PubMed

Herniou, Elisabeth A; Jehle, Johannes A

2007-10-01

The family Baculoviridae represents one of the largest and most diverse groups of viruses and a unique model for studying the forces driving the evolution and biodiversity of double-stranded DNA viruses with large genomes. With the advent of comparative genomics, the phylogenetic relationships of baculoviruses have been put on solid bases. This, as well as improved bioinformatic approaches, has provided a detailed picture of baculovirus phylogeny and evolution. According to the present knowledge, baculoviruses can be classified into at least four evolutionary lineages: the most ancestral dipteran nucleopolyhedroviruses, the hymenopteran nucleopolyhedroviruses and the lepidopteran nucleopolyhedroviruses and granuloviruses. Despite the growing understanding of baculovirus phylogeny and macro-evolution, our knowledge of the micro-evolutionary processes within baculovirus species and virus populations is still limited. Here we present the state of the art on baculovirus phylogeny and evolution.

Delegation to automaticity: the driving force for cognitive evolution?

PubMed

Shine, J M; Shine, R

2014-01-01

The ability to delegate control over repetitive tasks from higher to lower neural centers may be a fundamental innovation in human cognition. Plausibly, the massive neurocomputational challenges associated with the mastery of balance during the evolution of bipedality in proto-humans provided a strong selective advantage to individuals with brains capable of efficiently transferring tasks in this way. Thus, the shift from quadrupedal to bipedal locomotion may have driven the rapid evolution of distinctive features of human neuronal functioning. We review recent studies of functional neuroanatomy that bear upon this hypothesis, and identify ways to test our ideas.

A Dynamic Analysis of the Medium Tank Battalion. Volume I

DTIC Science & Technology

1978-06-01

best available copy. W. KEY WORDS (Cortinue an reverse oIde If necessary And Identifty block number) CONSTRUCTION; PLANNING; MANAGEMENT; MODELS...unit, with 64K, 8-bit bytes, (2) Dual-disk drive, 2 Discs at 262K, 8-bit bytes, (3) Cathode Ray Tube Console and Keyboard, (4) High- speed printer, (5

Computer controlled synchronous shifting of an automatic transmission

DOEpatents

Davis, Roy I.; Patil, Prabhakar B.

1989-01-01

A multiple forward speed automatic transmission produces its lowest forward speed ratio when a hydraulic clutch and hydraulic brake are disengaged and a one-way clutch connects a ring gear to the transmission casing. Second forward speed ratio results when the hydraulic clutch is engaged to connect the ring gear to the planetary carrier of a second gear set. Reverse drive and regenerative operation result when an hydraulic brake fixes the planetary and the direction of power flow is reversed. Various sensors produce signals representing the torque at the output of the transmission or drive wheels, the speed of the power source, and the hydraulic pressure applied to a clutch and brake. A control algorithm produces input data representing a commanded upshift, a commanded downshift, a commanded transmission output torque, and commanded power source speed. A microprocessor processes the inputs and produces a response to them in accordance with the execution of a control algorithm. Output or response signals cause selective engagement and disengagement of the clutch and brake at a rate that satisfies the requirements for a short gear ratio change and smooth torque transfer between the friction elements.

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.

PubMed

Zhang, Jimmy; Wang, Yves T; Miller, James H; Day, Mary M; Munger, Joshua C; Brookes, Paul S

2018-05-29

Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is proposed to involve reversal of mitochondrial complex II. Herein, using stable-isotope-resolved metabolomics, we demonstrate that complex II reversal is possible in hypoxic mitochondria but is not the primary succinate source in hypoxic cardiomyocytes or ischemic hearts. Rather, in these intact systems succinate primarily originates from canonical Krebs cycle activity, partly supported by aminotransferase anaplerosis and glycolysis from glycogen. Augmentation of canonical Krebs cycle activity with dimethyl-α-ketoglutarate both increases ischemic succinate accumulation and drives substrate-level phosphorylation by succinyl-CoA synthetase, improving ischemic energetics. Although two-thirds of ischemic succinate accumulation is extracellular, the remaining one-third is metabolized during early reperfusion, wherein acute complex II inhibition is protective. These results highlight a bifunctional role for succinate: its complex-II-independent accumulation being beneficial in ischemia and its complex-II-dependent oxidation being detrimental at reperfusion. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line.

PubMed

Vassbotn, F S; Ostman, A; Langeland, N; Holmsen, H; Westermark, B; Heldin, C H; Nistér, M

1994-02-01

Human glioblastoma cells (A172) were found to concomitantly express PDGF-BB and PDGF beta-receptors. The receptors were constitutively autophosphorylated in the absence of exogenous ligand, suggesting the presence of an autocrine PDGF pathway. Neutralizing PDGF antibodies as well as suramin inhibited the autonomous PDGF receptor tyrosine kinase activity and resulted in up-regulation of receptor protein. The interruption of the autocrine loop by the PDGF antibodies reversed the transformed phenotype of the glioblastoma cell, as determined by (1) diminished DNA synthesis, (2) inhibition of tumor colony growth, and (3) reversion of the transformed morphology of the tumor cells. The PDGF antibodies showed no effect on the DNA synthesis of another glioblastoma cells line (U-343MGa 31L) or on Ki-ras-transformed fibroblasts. The present study demonstrates an endogenously activated PDGF pathway in a spontaneous human glioblastoma cell line. Furthermore, we provide evidence that the autocrine PDGF pathway drives the transformed phenotype of the tumor cells, a process that can be blocked by extracellular antagonists.

The impact of supernova fragments on the evolution of multisupernova remnants

NASA Technical Reports Server (NTRS)

Franco, J.; Ferrara, A.; Rozyczka, M.; Tenorio-Tgale, G.; Cox, D. P.

1993-01-01

Analytical approximations and 2D hydrodynamical simulations are used to examine the interaction of supernova fragments with the internal structure of large multisupernova remnants (MSRs). The fragments are thermalized by reverse shocks generated in the interaction with the MSR interior, which is assumed to be hot and rarefied. The evolution is divided into two stages: before and after reaching a reference distance, R(E), from the explosion site. As the density of the expanding fragment drops, the reverse shock accelerates, and, when the distance R(E) is reached, it begins to effectively erode the fragment. At some selected evolutionary times, the X-ray emission from the shocked fragment is also calculated. The direct bombardment of the MRS shell by the shocked fragment has a series of important consequences: it excites, punctures, and deforms the expanding shell.

Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro

NASA Astrophysics Data System (ADS)

Yoshida, Mari; Reyes, Sabrina Galiñanes; Tsuda, Soichiro; Horinouchi, Takaaki; Furusawa, Chikara; Cronin, Leroy

2017-06-01

Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of antibiotics and switching between them in ON/OFF manner. Using a multiplexed cell culture system, we find that switching between certain combinations of antibiotics completely suppresses the development of resistance to one of the antibiotics. Using this data, we develop a simple deterministic model, which allows us to predict the fate of multi-drug evolution in this system. Furthermore, we are able to reverse established drug resistance based on the model prediction by modulating antibiotic selection stresses. Our results support the idea that the development of antibiotic resistance may be potentially controlled via continuous switching of drugs.

Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution

PubMed Central

Lambowitz, Alan M.; Belfort, Marlene

2015-01-01

SUMMARY This review focuses on recent developments in our understanding of group II intron function, the relationships of these introns to retrotransposons and spliceosomes, and how their common features have informed thinking about bacterial group II introns as key elements in eukaryotic evolution. Reverse transcriptase-mediated and host factor-aided intron retrohoming pathways are considered along with retrotransposition mechanisms to novel sites in bacteria, where group II introns are thought to have originated. DNA target recognition and movement by target-primed reverse transcription infer an evolutionary relationship among group II introns, non-LTR retrotransposons, such as LINE elements, and telomerase. Additionally, group II introns are almost certainly the progenitors of spliceosomal introns. Their profound similarities include splicing chemistry extending to RNA catalysis, reaction stereochemistry, and the position of two divalent metals that perform catalysis at the RNA active site. There are also sequence and structural similarities between group II introns and the spliceosome’s small nuclear RNAs (snRNAs) and between a highly conserved core spliceosomal protein Prp8 and a group II intron-like reverse transcriptase. It has been proposed that group II introns entered eukaryotes during bacterial endosymbiosis or bacterial-archaeal fusion, proliferated within the nuclear genome, necessitating evolution of the nuclear envelope, and fragmented giving rise to spliceosomal introns. Thus, these bacterial self-splicing mobile elements have fundamentally impacted the composition of extant eukaryotic genomes, including the human genome, most of which is derived from close relatives of mobile group II introns. PMID:25878921

Coevolution can reverse predator–prey cycles

PubMed Central

Cortez, Michael H.; Weitz, Joshua S.

2014-01-01

A hallmark of Lotka–Volterra models, and other ecological models of predator–prey interactions, is that in predator–prey cycles, peaks in prey abundance precede peaks in predator abundance. Such models typically assume that species life history traits are fixed over ecologically relevant time scales. However, the coevolution of predator and prey traits has been shown to alter the community dynamics of natural systems, leading to novel dynamics including antiphase and cryptic cycles. Here, using an eco-coevolutionary model, we show that predator–prey coevolution can also drive population cycles where the opposite of canonical Lotka–Volterra oscillations occurs: predator peaks precede prey peaks. These reversed cycles arise when selection favors extreme phenotypes, predator offense is costly, and prey defense is effective against low-offense predators. We present multiple datasets from phage–cholera, mink–muskrat, and gyrfalcon–rock ptarmigan systems that exhibit reversed-peak ordering. Our results suggest that such cycles are a potential signature of predator–prey coevolution and reveal unique ways in which predator–prey coevolution can shape, and possibly reverse, community dynamics. PMID:24799689

Coevolution can reverse predator-prey cycles.

PubMed

Cortez, Michael H; Weitz, Joshua S

2014-05-20

A hallmark of Lotka-Volterra models, and other ecological models of predator-prey interactions, is that in predator-prey cycles, peaks in prey abundance precede peaks in predator abundance. Such models typically assume that species life history traits are fixed over ecologically relevant time scales. However, the coevolution of predator and prey traits has been shown to alter the community dynamics of natural systems, leading to novel dynamics including antiphase and cryptic cycles. Here, using an eco-coevolutionary model, we show that predator-prey coevolution can also drive population cycles where the opposite of canonical Lotka-Volterra oscillations occurs: predator peaks precede prey peaks. These reversed cycles arise when selection favors extreme phenotypes, predator offense is costly, and prey defense is effective against low-offense predators. We present multiple datasets from phage-cholera, mink-muskrat, and gyrfalcon-rock ptarmigan systems that exhibit reversed-peak ordering. Our results suggest that such cycles are a potential signature of predator-prey coevolution and reveal unique ways in which predator-prey coevolution can shape, and possibly reverse, community dynamics.

Areal Mass Oscillations in Planar Targets Due to Feedout: Theory and Simulations.

NASA Astrophysics Data System (ADS)

Velikovich, A. L.; Schmitt, A. J.; Karasik, M.; Obenschain, S. P.; Serlin, V.; Pawley, C. J.; Gardner, J. H.; Aglitskiy, Y.; Metzler, N.

2001-10-01

When a planar shock wave breaks out at a rippled rear surface of a laser-driven target, the lateral pressure gradient in a rippled rarefaction wave propagating back to the front surface causes a lateral mass redistribution that reverses the phase of mass variation. If the driving laser pulse has no foot, then the RT growth, starting when the rarefaction wave reaches the front surface, causes the second phase reversal of mass variation, and continues at the initial phase, as consistently observed in feedout experiments on Nike. A foot of the laser pulse can cause an early phase reversal of mass variation, making the strong shock wave driven by the main pulse interact with a density variation in a rippled rarefaction wave rather than with static rear surface ripples. Theory and simulations predict that this interaction can make the phase of mass variation reverse one or three times. Then the phase of the RT growing mode would be opposite to that of the initial mass variation.

Effects of head field and AC field on magnetization reversal for microwave assisted magnetic recording

NASA Astrophysics Data System (ADS)

Kase, Aina; Akagi, Fumiko; Yoshida, Kazuetsu

2018-05-01

Microwave assisted magnetic recording (MAMR) is a promising recording method for achieving high recording densities in hard disk drives. In MAMR, the AC field from a spin-torque oscillator (STO) assists the head field with magnetization reversal in a medium. Therefore, the relationship between the head field and the AC field is very important. In this study, the effects of the head field and the AC field on magnetization reversal were analyzed using a micromagnetic simulator that takes the magnetic interactions between a single-pole type (SPT) write-head, an exchange coupled composite (ECC) medium, and the STO into account. As a result, the magnetization reversal was assisted not just by the y-component of the AC field (Hstoy) but also by the y-component of the head field (Hhy) in the medium. The Hhy over 100 kA/m with a frequency of about 15.5 GHz induced the magnetic resonance. The large Hhy was produced by the field from the STO to the SPT head.

Magnetic drops in a soft-magnetic cylinder

NASA Astrophysics Data System (ADS)

Hertel, Riccardo; Kirschner, Jürgen

2004-07-01

Magnetization reversal in a cylindrical ferromagnetic particle seems to be a simple textbook problem in magnetism. But at a closer look, the magnetization reversal dynamics in a cylinder is far from being trivial. The difficulty arises from the central axis, where the magnetization switches in a discontinuous fashion. Micromagnetic computer simulations allow for a detailed description of the evolution of the magnetic structure on the sub-nanosecond time scale. The switching process involves the injection of a magnetic point singularity (Bloch point) into the cylinder. Further point singularities may be generated and annihilated periodically during the reversal process. This results in the temporary formation of micromagnetic drops, i.e., isolated, non-reversed regions. This surprising feature in dynamic micromagnetism is due to different mobilities of domain wall and Bloch point.

Time reversibility of quantum diffusion in small-world networks

NASA Astrophysics Data System (ADS)

Han, Sung-Guk; Kim, Beom Jun

2012-02-01

We study the time-reversal dynamics of a tight-binding electron in the Watts-Strogatz (WS) small-world networks. The localized initial wave packet at time t = 0 diffuses as time proceeds until the time-reversal operation, together with the momentum perturbation of the strength η, is made at the reversal time T. The time irreversibility is measured by I = |Π( t = 2 T) - Π( t = 0)|, where Π is the participation ratio gauging the extendedness of the wavefunction and for convenience, t is measured forward even after the time reversal. When η = 0, the time evolution after T makes the wavefunction at t = 2 T identical to the one at t = 0, and we find I = 0, implying a null irreversibility or a complete reversibility. On the other hand, as η is increased from zero, the reversibility becomes weaker, and we observe enhancement of the irreversibility. We find that I linearly increases with increasing η in the weakly-perturbed region, and that the irreversibility is much stronger in the WS network than in the local regular network.

Role of Interfaces and Interphases in the Evolution Mechanics of Material Systems

DTIC Science & Technology

1992-03-26

K. REIFSNIDER, W. STINCHCOMB, D. DILLARD, R. SWAIN, K. JAYARAMAN, Y. CHlANG J. LESKO, M. ELAHI, Z. GAO, A. RAZVAN Nlatcrials Response Group 92- 12953...1/91 1 26 March 1992 SUPPLEMENTARY NOTATION COSATI CODES 18. SUBJECT TERMS (Continue on reverse if necessary and identify by block number) FIELD GROUP ...SUB- GROUP ABSTRACT (Continue on reverse if necessary and identify by block number) This final report summarizes the activities conducted under this

Efficient common-envelope ejection through dust-driven winds

NASA Astrophysics Data System (ADS)

Glanz, Hila; Perets, Hagai B.

2018-04-01

Common-envelope evolution (CEE) is the short-lived phase in the life of an interacting binary-system during which two stars orbit inside a single shared envelope. Such evolution is thought to lead to the inspiral of the binary, the ejection of the extended envelope and the formation of a remnant short-period binary. However, detailed hydrodynamical models of CEE encounter major difficulties. They show that following the inspiral most of the envelope is not ejected; though it expands to larger separations, it remains bound to the binary. Here we propose that dust-driven winds can be produced following the CEE. These can evaporate the envelope following similar processes operating in the ejection of the envelopes of AGB stars. Pulsations in an AGB-star drives the expansion of its envelope, allowing the material to cool down to low temperatures thus enabling dust condensation. Radiation pressure on the dust accelerates it, and through its coupling to the gas it drives winds which eventually completely erode the envelope. We show that the inspiral phase in CE-binaries can effectively replace the role of stellar pulsation and drive the CE expansion to scales comparable with those of AGB stars, and give rise to efficient mass-loss through dust-driven winds.

Quantum Nonlinear Hall Effect Induced by Berry Curvature Dipole in Time-Reversal Invariant Materials.

PubMed

Sodemann, Inti; Fu, Liang

2015-11-20

It is well known that a nonvanishing Hall conductivity requires broken time-reversal symmetry. However, in this work, we demonstrate that Hall-like currents can occur in second-order response to external electric fields in a wide class of time-reversal invariant and inversion breaking materials, at both zero and twice the driving frequency. This nonlinear Hall effect has a quantum origin arising from the dipole moment of the Berry curvature in momentum space, which generates a net anomalous velocity when the system is in a current-carrying state. The nonlinear Hall coefficient is a rank-two pseudotensor, whose form is determined by point group symmetry. We discus optimal conditions to observe this effect and propose candidate two- and three-dimensional materials, including topological crystalline insulators, transition metal dichalcogenides, and Weyl semimetals.

Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides.

PubMed

Undheim, Eivind A B; Mobli, Mehdi; King, Glenn F

2016-06-01

Three-dimensional (3D) structures have been used to explore the evolution of proteins for decades, yet they have rarely been utilized to study the molecular evolution of peptides. Here, we highlight areas in which 3D structures can be particularly useful for studying the molecular evolution of peptide toxins. Although we focus our discussion on animal toxins, including one of the most widespread disulfide-rich peptide folds known, the inhibitor cystine knot, our conclusions should be widely applicable to studies of the evolution of disulfide-constrained peptides. We show that conserved 3D folds can be used to identify evolutionary links and test hypotheses regarding the evolutionary origin of peptides with extremely low sequence identity; construct accurate multiple sequence alignments; and better understand the evolutionary forces that drive the molecular evolution of peptides. Also watch the video abstract. © 2016 WILEY Periodicals, Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Ying-Jie, E-mail: yingjiezhang@qfnu.edu.cn; Han, Wei; Xia, Yun-Jie, E-mail: yjxia@qfnu.edu.cn

We propose a scheme of controlling entanglement dynamics of a quantum system by applying the external classical driving field for two atoms separately located in a single-mode photon cavity. It is shown that, with a judicious choice of the classical-driving strength and the atom–photon detuning, the effective atom–photon interaction Hamiltonian can be switched from Jaynes–Cummings model to anti-Jaynes–Cummings model. By tuning the controllable atom–photon interaction induced by the classical field, we illustrate that the evolution trajectory of the Bell-like entanglement states can be manipulated from entanglement-sudden-death to no-entanglement-sudden-death, from no-entanglement-invariant to entanglement-invariant. Furthermore, the robustness of the initial Bell-like entanglementmore » can be improved by the classical driving field in the leaky cavities. This classical-driving-assisted architecture can be easily extensible to multi-atom quantum system for scalability.« less

Centromeres Drive a Hard Bargain

PubMed Central

Rosin, Leah F.; Mellone, Barbara G.

2017-01-01

Centromeres are essential chromosomal structures that mediate the accurate distribution of genetic material during meiotic and mitotic cell divisions. In most organisms, centromeres are epigenetically specified and propagated by nucleosomes containing the centromere-specific H3 variant, CENP-A. Although centromeres perform a critical and conserved function, CENP-A and the underlying centromeric DNA are rapidly evolving. This paradox has been explained by the centromere drive hypothesis, which proposes that CENP-A is undergoing an evolutionary tug-of-war with selfish centromeric DNA. Here, we review our current understanding of CENP-A evolution in relation to centromere drive and discuss classical and recent advances, including new evidence implicating CENP-A chaperones in this conflict. PMID:28069312

Multiple exciton generation for photoelectrochemical hydrogen evolution reactions with quantum yields exceeding 100%

DOE PAGES

Yan, Yong; Crisp, Ryan W.; Gu, Jing; ...

2017-04-03

Multiple exciton generation (MEG) in quantum dots (QDs) has the potential to greatly increase the power conversion efficiency in solar cells and in solar-fuel production. During the MEG process, two electron-hole pairs (excitons) are created from the absorption of one high-energy photon, bypassing hot-carrier cooling via phonon emission. Here we demonstrate that extra carriers produced via MEG can be used to drive a chemical reaction with quantum efficiency above 100%. We developed a lead sulfide (PbS) QD photoelectrochemical cell that is able to drive hydrogen evolution from aqueous Na 2S solution with a peak external quantum efficiency exceeding 100%. QDmore » photoelectrodes that were measured all demonstrated MEG when the incident photon energy was larger than 2.7 times the bandgap energy. Finally, our results demonstrate a new direction in exploring high-efficiency approaches to solar fuels.« less

Reversibility and energy dissipation in adiabatic superconductor logic.

PubMed

Takeuchi, Naoki; Yamanashi, Yuki; Yoshikawa, Nobuyuki

2017-03-06

Reversible computing is considered to be a key technology to achieve an extremely high energy efficiency in future computers. In this study, we investigated the relationship between reversibility and energy dissipation in adiabatic superconductor logic. We analyzed the evolution of phase differences of Josephson junctions in the reversible quantum-flux-parametron (RQFP) gate and confirmed that the phase differences can change time reversibly, which indicates that the RQFP gate is physically, as well as logically, reversible. We calculated energy dissipation required for the RQFP gate to perform a logic operation and numerically demonstrated that the energy dissipation can fall below the thermal limit, or the Landauer bound, by lowering operation frequencies. We also investigated the 1-bit-erasure gate as a logically irreversible gate and the quasi-RQFP gate as a physically irreversible gate. We calculated the energy dissipation of these irreversible gates and showed that the energy dissipation of these gate is dominated by non-adiabatic state changes, which are induced by unwanted interactions between gates due to logical or physical irreversibility. Our results show that, in reversible computing using adiabatic superconductor logic, logical and physical reversibility are required to achieve energy dissipation smaller than the Landauer bound without non-adiabatic processes caused by gate interactions.

Spatial and Temporal Variations in Slip Partitioning During Oblique Convergence Experiments

NASA Astrophysics Data System (ADS)

Beyer, J. L.; Cooke, M. L.; Toeneboehn, K.

2017-12-01

Physical experiments of oblique convergence in wet kaolin demonstrate the development of slip partitioning, where two faults accommodate strain via different slip vectors. In these experiments, the second fault forms after the development of the first fault. As one strain component is relieved by one fault, the local stress field then favors the development of a second fault with different slip sense. A suite of physical experiments reveals three styles of slip partitioning development controlled by the convergence angle and presence of a pre-existing fault. In experiments with low convergence angles, strike-slip faults grow prior to reverse faults (Type 1) regardless of whether the fault is precut or not. In experiments with moderate convergence angles, slip partitioning is dominantly controlled by the presence of a pre-existing fault. In all experiments, the primarily reverse fault forms first. Slip partitioning then develops with the initiation of strike-slip along the precut fault (Type 2) or growth of a secondary reverse fault where the first fault is steepest. Subsequently, the slip on the first fault transitions to primarily strike-slip (Type 3). Slip rates and rakes along the slip partitioned faults for both precut and uncut experiments vary temporally, suggesting that faults in these slip-partitioned systems are constantly adapting to the conditions produced by slip along nearby faults in the system. While physical experiments show the evolution of slip partitioning, numerical simulations of the experiments provide information about both the stress and strain fields, which can be used to compute the full work budget, providing insight into the mechanisms that drive slip partitioning. Preliminary simulations of precut experiments show that strain energy density (internal work) can be used to predict fault growth, highlighting where fault growth can reduce off-fault deformation in the physical experiments. In numerical simulations of uncut experiments with a first non-planar oblique slip fault, strain energy density is greatest where the first fault is steepest, as less convergence is accommodated along this portion of the fault. The addition of a second slip-partitioning fault to the system decreases external work indicating that these faults increase the mechanical efficiency of the system.

Thermophilic Bacteria: Their Relationships to Other Bacteria and Role in Archaebacterial and Eubacterial Evolution

DTIC Science & Technology

1988-05-25

reverse if necessary and identify by block numoer) FIELD GROUP SUB-GROUP phylogeny; evolution PJ 06 103 Key Words - archaebacteria ;eubacteria...branching representatives of the eubacterial kingdom (yet known) are, without exception, thermophilic, which is also the 6ra case for the archaebacterial... kingdom . A bacterium isolated from the Red Sea by Prof. Karl Stetter has proven to be difficult to grow in the quantities required for RNA sequencing

Disentangling the Dynamical Mechanisms for Cluster Galaxy Evolution

DTIC Science & Technology

2008-02-01

reversible energy and angular momentum exchange between the density wave and the disk matter and the outward transport of these exchanged energy and angular...elapsed time for a smaller z as well. Yet the argument should hold no matter what observation epoch one uses, as long as one concentrates to the regions... matter (CDM) paradigm, galaxy mergers are the preferred means of morphological evolution of galaxies in clusters (see, e.g., Kauffmann 1995). Even though

Active tectonics and drainage evolution in the Tunisian Atlas driven by interaction between crustal shortening and slab pull

NASA Astrophysics Data System (ADS)

Camafort, Miquel; Booth-Rea, Guillermo; Pérez-Peña, Jose Vicente; Melki, Fetheddine; Gracia, Eulalia; Azañón, Jose Miguel; Ranero, César R.

2017-04-01

Active tectonics in North Africa is fundamentally driven by NW-SE directed slow convergence between the Nubia and Eurasia plates, leading to a region of thrust and strike-slip faulting. In this paper we analyze the morphometric characteristics of the little-studied northern Tunisia sector. The study aimed at identifying previously unknown active tectonic structures, and to further understand the mechanisms that drive the drainage evolution in this region of slow convergence. The interpretation of morphometric data was supported with a field campaign of a selection of structures. The analysis indicates that recent fluvial captures have been the main factor rejuvenating drainage catchments. The Medjerda River, which is the main catchment in northern Tunisia, has increased its drainage area during the Quaternary by capturing adjacent axial valleys to the north and south of its drainage divide. These captures are probably driven by gradual uplift of adjacent axial valleys by reverse/oblique faults or associated folds like El Alia-Teboursouk and Dkhila faults. Our fieldwork found that these faults cut Holocene colluvial fans containing seismites like clastic dikes and sand volcanoes, indicating recent seismogenic faulting. The growth and stabilization of the axial Medjerda River against the natural tendency of transverse drainages might be caused by a combination of dynamic topography and transpressive tectonics. The orientation of the large axial Medjerda drainage that runs from eastern Algeria towards northeastern Tunisia into the Gulf of Tunis, might be the associated to negative buoyancy caused by the underlying Nubia slab at its mouth, together with uplift of the Medjerda headwaters along the South Atlassic dextral transfer zone.

Information dynamics in living systems: prokaryotes, eukaryotes, and cancer.

PubMed

Frieden, B Roy; Gatenby, Robert A

2011-01-01

Living systems use information and energy to maintain stable entropy while far from thermodynamic equilibrium. The underlying first principles have not been established. We propose that stable entropy in living systems, in the absence of thermodynamic equilibrium, requires an information extremum (maximum or minimum), which is invariant to first order perturbations. Proliferation and death represent key feedback mechanisms that promote stability even in a non-equilibrium state. A system moves to low or high information depending on its energy status, as the benefit of information in maintaining and increasing order is balanced against its energy cost. Prokaryotes, which lack specialized energy-producing organelles (mitochondria), are energy-limited and constrained to an information minimum. Acquisition of mitochondria is viewed as a critical evolutionary step that, by allowing eukaryotes to achieve a sufficiently high energy state, permitted a phase transition to an information maximum. This state, in contrast to the prokaryote minima, allowed evolution of complex, multicellular organisms. A special case is a malignant cell, which is modeled as a phase transition from a maximum to minimum information state. The minimum leads to a predicted power-law governing the in situ growth that is confirmed by studies measuring growth of small breast cancers. We find living systems achieve a stable entropic state by maintaining an extreme level of information. The evolutionary divergence of prokaryotes and eukaryotes resulted from acquisition of specialized energy organelles that allowed transition from information minima to maxima, respectively. Carcinogenesis represents a reverse transition: of an information maximum to minimum. The progressive information loss is evident in accumulating mutations, disordered morphology, and functional decline characteristics of human cancers. The findings suggest energy restriction is a critical first step that triggers the genetic mutations that drive somatic evolution of the malignant phenotype.

Bringing MapReduce Closer To Data With Active Drives

NASA Astrophysics Data System (ADS)

Golpayegani, N.; Prathapan, S.; Warmka, R.; Wyatt, B.; Halem, M.; Trantham, J. D.; Markey, C. A.

2017-12-01

Moving computation closer to the data location has been a much theorized improvement to computation for decades. The increase in processor performance, the decrease in processor size and power requirement combined with the increase in data intensive computing has created a push to move computation as close to data as possible. We will show the next logical step in this evolution in computing: moving computation directly to storage. Hypothetical systems, known as Active Drives, have been proposed as early as 1998. These Active Drives would have a general-purpose CPU on each disk allowing for computations to be performed on them without the need to transfer the data to the computer over the system bus or via a network. We will utilize Seagate's Active Drives to perform general purpose parallel computing using the MapReduce programming model directly on each drive. We will detail how the MapReduce programming model can be adapted to the Active Drive compute model to perform general purpose computing with comparable results to traditional MapReduce computations performed via Hadoop. We will show how an Active Drive based approach significantly reduces the amount of data leaving the drive when performing several common algorithms: subsetting and gridding. We will show that an Active Drive based design significantly improves data transfer speeds into and out of drives compared to Hadoop's HDFS while at the same time keeping comparable compute speeds as Hadoop.

Controlling the Local Electronic Properties of Si(553)-Au through Hydrogen Doping

NASA Astrophysics Data System (ADS)

Hogan, C.; Speiser, E.; Chandola, S.; Suchkova, S.; Aulbach, J.; Schäfer, J.; Meyer, S.; Claessen, R.; Esser, N.

2018-04-01

We propose a quantitative and reversible method for tuning the charge localization of Au-stabilized stepped Si surfaces by site-specific hydrogenation. This is demonstrated for Si(553)-Au as a model system by combining density functional theory simulations and reflectance anisotropy spectroscopy experiments. We find that controlled H passivation is a two-step process: step-edge adsorption drives excess charge into the conducting metal chain "reservoir" and renders it insulating, while surplus H recovers metallic behavior. Our approach illustrates a route towards microscopic manipulation of the local surface charge distribution and establishes a reversible switch of site-specific chemical reactivity and magnetic properties on vicinal surfaces.

Bandwidth-induced reversal of asymmetry in optical-double-resonance amplitudes

NASA Astrophysics Data System (ADS)

Nitz, D. E.; Smith, A. V.; Levenson, M. D.; Smith, S. J.

1981-07-01

Optical-double-resonance measurements using ionization detection have been carried out in the 3S12-3P12-4D atomic-sodium system. Asymmetries observed in production of 4D atoms from the two components of the Stark-split 3P12 state are found to be controlled by the far, very weak wings of the 17-MHz full-width-at-half-maximum laser line which is used to drive the 3S12-3P12 transition at detunings in the range 0-70 GHz. Suppression of the wings with a Fabry-Perot filter causes a pronounced reversal of the asymmetry.

Cultural evolution: The case of babies’ first names

NASA Astrophysics Data System (ADS)

Xi, Ning; Zhang, Zi-Ke; Zhang, Yi-Cheng; Ge, Zehui; She, Li; Zhang, Kui

2014-07-01

In social sciences, there is currently rare consensus on the underlying mechanism for cultural evolution, partially due to lack of suitable data. The evolution of first names of newborn babies offers a remarkable example for such researches. In this paper, we employ the historical data on baby names from the United States to investigate the evolutionary process of culture, in particular focusing on how inequality among baby names changes over time. Then we propose a stochastic model where individual choice is determined by both individual preference and social influence, and show that the decrease in the strength of social influence can account for all the observed empirical features. Therefore, we claim that the weakening of social influence drives cultural evolution.

Cosmological bounce and Genesis beyond Horndeski

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolevatov, R.; Mironov, S.; Volkova, V.

2017-08-01

We study 'classical' bouncing and Genesis models in beyond Horndeski theory. We give an example of spatially flat bouncing solution that is non-singular and stable throughout the whole evolution. We also provide an example of stable geodesically complete Genesis with similar features. The model is arranged in such a way that the scalar field driving the cosmological evolution initially behaves like full-fledged beyond Horndeski, whereas at late times it becomes a massless scalar field minimally coupled to gravity.

Perceptual elements in brain mechanisms of acoustic communication in humans and nonhuman primates.

PubMed

Reser, David H; Rosa, Marcello

2014-12-01

Ackermann et al. outline a model for elaboration of subcortical motor outputs as a driving force for the development of the apparently unique behaviour of language in humans. They emphasize circuits in the striatum and midbrain, and acknowledge, but do not explore, the importance of the auditory perceptual pathway for evolution of verbal communication. We suggest that understanding the evolution of language will also require understanding of vocalization perception, especially in the auditory cortex.

The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice.

PubMed

Kingsley, Evan P; Kozak, Krzysztof M; Pfeifer, Susanne P; Yang, Dou-Shuan; Hoekstra, Hopi E

2017-02-01

Understanding both the role of selection in driving phenotypic change and its underlying genetic basis remain major challenges in evolutionary biology. Here, we use modern tools to revisit a classic system of local adaptation in the North American deer mouse, Peromyscus maniculatus, which occupies two main habitat types: prairie and forest. Using historical collections, we find that forest-dwelling mice have longer tails than those from nonforested habitat, even when we account for individual and population relatedness. Using genome-wide SNP data, we show that mice from forested habitats in the eastern and western parts of their range form separate clades, suggesting that increased tail length evolved independently. We find that forest mice in the east and west have both more and longer caudal vertebrae, but not trunk vertebrae, than nearby prairie forms. By intercrossing prairie and forest mice, we show that the number and length of caudal vertebrae are not correlated in this recombinant population, indicating that variation in these traits is controlled by separate genetic loci. Together, these results demonstrate convergent evolution of the long-tailed forest phenotype through two distinct genetic mechanisms, affecting number and length of vertebrae, and suggest that these morphological changes-either independently or together-are adaptive. © 2016 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution.

Accumulation of electric currents driving jetting events in the solar atmosphere

NASA Astrophysics Data System (ADS)

Vargas Domínguez, S.; Guo, Y.; Demoulin, P.; Schmieder, B.; Ding, M.; Liu, Y.

2013-12-01

The solar atmosphere is populated with a wide variety of structures and phenomena at different spatial and temporal scales. Explosive phenomena are of particular interest due to their contribution to the atmosphere's energy budget and their implications, e.g. coronal heating. Recent instrumental developments have provided important observations and therefore new insights for tracking the dynamic evolution of the solar atmosphere. Jets of plasma are frequently observed in the solar corona and are thought to be a consequence of magnetic reconnection, however, the physics involved is not fully understood. Unprecedented observations (EUV and vector magnetic fields) are used to study solar jetting events, from which we derive the magnetic flux evolution, the photospheric velocity field, and the vertical electric current evolution. The evolution of magnetic parasitic polarities displaying diverging flows are detected to trigger recurrent jets in a solar regionon 17 September 2010. The interaction drive the build up of electric currents. Observed diverging flows are proposed to build continuously such currents. Magnetic reconnection is proposed to occur periodically, in the current layer created between the emerging bipole and the large scale active region field. SDO/AIA EUV composite images. Upper: SDO/AIA 171 Å image overlaid by the line-of-sight magnetic field observed at the same time as that of the 171 Å image. Lower: Map of photospheric transverse velocities derived from LCT analysis with the HMI magnetograms.

The Red Queen in mitochondria: cyto-nuclear co-evolution, hybrid breakdown and human disease

PubMed Central

Chou, Jui-Yu; Leu, Jun-Yi

2015-01-01

Cyto-nuclear incompatibility, a specific form of Dobzhansky-Muller incompatibility caused by incompatible alleles between mitochondrial and nuclear genomes, has been suggested to play a critical role during speciation. Several features of the mitochondrial genome (mtDNA), including high mutation rate, dynamic genomic structure, and uniparental inheritance, make mtDNA more likely to accumulate mutations in the population. Once mtDNA has changed, the nuclear genome needs to play catch-up due to the intimate interactions between these two genomes. In two populations, if cyto-nuclear co-evolution is driven in different directions, it may eventually lead to hybrid incompatibility. Although cyto-nuclear incompatibility has been observed in a wide range of organisms, it remains unclear what type of mutations drives the co-evolution. Currently, evidence supporting adaptive mutations in mtDNA remains limited. On the other hand, it has been known that some mutations allow mtDNA to propagate more efficiently but compromise the host fitness (described as selfish mtDNA). Arms races between such selfish mtDNA and host nuclear genomes can accelerate cyto-nuclear co-evolution and lead to a phenomenon called the Red Queen Effect. Here, we discuss how the Red Queen Effect may contribute to the frequent observation of cyto-nuclear incompatibility and be the underlying driving force of some human mitochondrial diseases. PMID:26042149

Feedback between environment and traits under selection in a seasonal environment: consequences for experimental evolution.

PubMed

Collot, Dorian; Nidelet, Thibault; Ramsayer, Johan; Martin, Olivier C; Méléard, Sylvie; Dillmann, Christine; Sicard, Delphine; Legrand, Judith

2018-04-11

Batch cultures are frequently used in experimental evolution to study the dynamics of adaptation. Although they are generally considered to simply drive a growth rate increase, other fitness components can also be selected for. Indeed, recurrent batches form a seasonal environment where different phases repeat periodically and different traits can be under selection in the different seasons. Moreover, the system being closed, organisms may have a strong impact on the environment. Thus, the study of adaptation should take into account the environment and eco-evolutionary feedbacks. Using data from an experimental evolution on yeast Saccharomyces cerevisiae , we developed a mathematical model to understand which traits are under selection, and what is the impact of the environment for selection in a batch culture. We showed that two kinds of traits are under selection in seasonal environments: life-history traits, related to growth and mortality, but also transition traits, related to the ability to react to environmental changes. The impact of environmental conditions can be summarized by the length of the different seasons which weight selection on each trait: the longer a season is, the higher the selection on associated traits. Since phenotypes drive season length, eco-evolutionary feedbacks emerge. Our results show how evolution in successive batches can affect season lengths and strength of selection on different traits. © 2018 The Author(s).

Anisotropic heat transport in reversed shear configurations: shearless Cantori barriers and nonlocal transport

NASA Astrophysics Data System (ADS)

Blasevski, D.; Del-Castillo-Negrete, D.

2012-10-01

Heat transport in magnetized plasmas is a problem of fundamental interest in controlled fusion. In Ref.footnotetext D. del-Castillo-Negrete, and L. Chac'on, Phys. Rev. Lett., 106, 195004 (2011); Phys. Plasmas 19, 056112 (2012). we proposed a Lagrangian-Green's function (LG) method to study this problem in the strongly anisotropic (χ=0) regime. The LG method bypasses the need to discretize the transport operators on a grid and it is applicable to general parallel flux closures and 3-D magnetic fields. Here we apply the LG method to parallel transport (with local and nonlocal parallel flux closures) in reversed shear magnetic field configurations known to exhibit robust transport barriers in the vicinity of the extrema of the q-profile. By shearless Cantori (SC) we mean the invariant Cantor sets remaining after the destruction of toroidal flux surfaces with zero magnetic shear, q^'=0. We provide numerical evidence of the role of SC in the anomalously slow relaxation of radial temperature gradients in chaotic magnetic fields with no transport barriers. The spatio-temporal evolution of temperature pulses localized in the reversed shear region exhibits non-diffusive self-similar evolution and nonlocal effective radial transport.

Numerical Calculation and Experiment of Coupled Dynamics of the Differential Velocity Vane Pump Driven by the Hybrid Higher-order Fourier Non-circular Gears

NASA Astrophysics Data System (ADS)

Xu, Gaohuan; Chen, Jianneng; Zhao, Huacheng

2018-06-01

The transmission systems of the differential velocity vane pumps (DVVP) have periodic vibrations under loads. And it is not easy to find the reason. In order to optimize the performance of the pump, the authors proposed DVVP driven by the hybrid Higher-order Fourier non-circular gears and tested it. There were also similar periodic vibrations and noises under loads. Taking into account this phenomenon, the paper proposes fluid mechanics and solid mechanics simulation methodology to analyze the coupling dynamics between fluid and transmission system and reveals the reason. The results show that the pump has the reverse drive phenomenon, which is that the blades drive the non-circular gears when the suction and discharge is alternating. The reverse drive phenomenon leads the sign of the shaft torque to be changed in positive and negative way. So the transmission system produces torsional vibrations. In order to confirm the simulation results, micro strains of the input shaft of the pump impeller are measured by the Wheatstone bridge and wireless sensor technology. The relationships between strain and torque are obtained by experimental calibration, and then the true torque of input shaft is calculated indirectly. The experimental results are consistent to the simulation results. It is proven that the periodic vibrations are mainly caused by fluid solid coupling, which leads to periodic torsional vibration of the transmission system.

Aspect-ratio dependence of magnetization reversal in cylindrical ferromagnetic nanowires

NASA Astrophysics Data System (ADS)

Sultan, Musaab S.; Atkinson, Del

2016-05-01

The magnetization reversal behavior in isolated cylindrical and square cross-section Ni81Fe19 nanowires was systematically studied as a function of nanowire cross-section dimensions from 10 up to 200 nm using micromagnetic simulations. This approach provides access to the switching field, remanence ratio and most significantly the magnetization structures during reversal, which allows the evolution of magnetization processes to be studied with scaling of the cross-sectional dimensions. The dimensional trends in reversal behavior for both square and circular cross-section were comparable throughout the range of dimensions studied. The thinnest nanowires showed simple square switching and 100% remanence. With increasing diameter the switching field reduces and above 40 nm the reversal behavior shows an increasing rotational component prior to sharp switching of the magnetization. The magnitude of the reversible component increases with increasing dimensions up to 150 nm, above which the magnetization reversal process is more complicated and the hysteresis loops are no longer bistable. The micromagnetic structures evolve from simple uniform parallel single domain states in the thinnest wires through the formation of vortex-like end states in thicker wires to complex multidomain structures during the reversal of the thickest wires. In the later cases the reversal is not simple curling-like behavior, although the angular switching field dependence was comparable with curling.

Austenitic Reversion of Cryo-rolled Ti-Stabilized Austenitic Stainless Steel: High-Resolution EBSD Investigation

NASA Astrophysics Data System (ADS)

Tiamiyu, A. A.; Odeshi, A. G.; Szpunar, J. A.

2018-02-01

In this study, AISI 321 austenitic stainless steel (ASS) was cryo-rolled and subsequently annealed at 650 and 800 °C to reverse BCC α'-martensite to FCC γ-austenite. The texture evolution associated with the reversion at the selected temperatures was investigated using high-resolution EBSD. After the reversion, TiC precipitates were observed to be more stable in 650 °C-annealed specimens than those reversed at 800 °C. {110} texture was mainly developed in specimens subjected to both annealing temperatures. However, specimens reversed at 650 °C have stronger texture than those annealed at 800 °C, even at the higher annealing time. The strong intensity of {110} texture component is attributed to the ability of AISI 321 ASS to memorize the crystallographic orientation of the deformed austenite, a phenomenon termed texture memory. The development of weaker texture in 800 °C-annealed specimens is attributed to the residual strain relief in grains, dissolution of grain boundary precipitates, and an increase in atomic migration along the grain boundaries. Based on the observed features of the reversed austenite grains and estimation from an existing model, it is suspected that the austenite reversion at 650 and 800 °C undergone diffusional and martensitic shear reversion, respectively.

A simple analytical model for signal amplification by reversible exchange (SABRE) process.

PubMed

Barskiy, Danila A; Pravdivtsev, Andrey N; Ivanov, Konstantin L; Kovtunov, Kirill V; Koptyug, Igor V

2016-01-07

We demonstrate an analytical model for the description of the signal amplification by reversible exchange (SABRE) process. The model relies on a combined analysis of chemical kinetics and the evolution of the nuclear spin system during the hyperpolarization process. The presented model for the first time provides rationale for deciding which system parameters (i.e. J-couplings, relaxation rates, reaction rate constants) have to be optimized in order to achieve higher signal enhancement for a substrate of interest in SABRE experiments.

Aircraft Derived Low Level Winds and Upwelling Off the Peruvian Cost during March, April, and May 1977.

DTIC Science & Technology

1979-08-01

Force Institute of Technology (ATC) ~ vih -Patterson AFB,. OH 45433 19. KEY WORDS (Continue on reverse side if necessary and identify by block number) 20...per- manent high located west of Chile drives the consistent southerly winds, while the more variable ocean currents pro- vide the colder subsurface

How Is Theory of Mind Useful? Perhaps to Enable Social Pretend Play

ERIC Educational Resources Information Center

Dore, Rebecca A.; Smith, Eric D.; Lillard, Angeline S.

2015-01-01

It is often claimed that theory of mind is facilitated by pretend play. This perspective piece challenges that view, proposing instead that theory of mind might be useful for driving social pretend play, rather than the reverse. There is a fundamental similarity between pretend play and theory of mind. Pretend play involves projecting a different…

Cognition and the evolution of camouflage.

PubMed

Skelhorn, John; Rowe, Candy

2016-02-24

Camouflage is one of the most widespread forms of anti-predator defence and prevents prey individuals from being detected or correctly recognized by would-be predators. Over the past decade, there has been a resurgence of interest in both the evolution of prey camouflage patterns, and in understanding animal cognition in a more ecological context. However, these fields rarely collide, and the role of cognition in the evolution of camouflage is poorly understood. Here, we review what we currently know about the role of both predator and prey cognition in the evolution of prey camouflage, outline why cognition may be an important selective pressure driving the evolution of camouflage and consider how studying the cognitive processes of animals may prove to be a useful tool to study the evolution of camouflage, and vice versa. In doing so, we highlight that we still have a lot to learn about the role of cognition in the evolution of camouflage and identify a number of avenues for future research. © 2016 The Author(s).

Cognition and the evolution of camouflage

PubMed Central

2016-01-01

Camouflage is one of the most widespread forms of anti-predator defence and prevents prey individuals from being detected or correctly recognized by would-be predators. Over the past decade, there has been a resurgence of interest in both the evolution of prey camouflage patterns, and in understanding animal cognition in a more ecological context. However, these fields rarely collide, and the role of cognition in the evolution of camouflage is poorly understood. Here, we review what we currently know about the role of both predator and prey cognition in the evolution of prey camouflage, outline why cognition may be an important selective pressure driving the evolution of camouflage and consider how studying the cognitive processes of animals may prove to be a useful tool to study the evolution of camouflage, and vice versa. In doing so, we highlight that we still have a lot to learn about the role of cognition in the evolution of camouflage and identify a number of avenues for future research. PMID:26911959

Herbivory as an important selective force in the evolution of floral traits and pollinator shifts

PubMed Central

Overson, Rick P.; Raguso, Robert A.; Skogen, Krissa A.

2017-01-01

Abstract Floral trait evolution is frequently attributed to pollinator-mediated selection but herbivores can play a key role in shaping plant reproductive biology. Here we examine the role of florivores in driving floral trait evolution and pollinator shifts in a recently radiated clade of flowering plants, Oenothera sect. Calylophus. We compare florivory by a specialist, internal feeder, Mompha, on closely related hawkmoth- and bee-pollinated species and document variation in damage based on floral traits within sites, species and among species. Our results show that flowers with longer floral tubes and decreased floral flare have increased Mompha damage. Bee-pollinated flowers, which have substantially smaller floral tubes, experience on average 13% less Mompha florivory than do hawkmoth-pollinated flowers. The positive association between tube length and Mompha damage is evident even within sites of some species, suggesting that Mompha can drive trait differentiation at microevolutionary scales. Given that there are at least two independent shifts from hawkmoth to bee pollination in this clade, florivore-mediated selection on floral traits may have played an important role in facilitating morphological changes associated with transitions from hawkmoth to bee pollination. PMID:28011456

Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications

PubMed Central

2013-01-01

Multiple subclonal populations of tumor cells can coexist within the same tumor. This intra-tumor heterogeneity will have clinical implications and it is therefore important to identify factors that drive or suppress such heterogeneous tumor progression. Evolutionary biology can provide important insights into this process. In particular, experimental evolution studies of microbial populations, which exist as clonal populations that can diversify into multiple subclones, have revealed important evolutionary processes driving heterogeneity within a population. There are transferrable lessons that can be learnt from these studies that will help us to understand the process of intra-tumor heterogeneity in the clinical setting. In this review, we summarize drivers of microbial diversity that have been identified, such as mutation rate and environmental influences, and discuss how knowledge gained from microbial experimental evolution studies may guide us to identify and understand important selective factors that promote intra-tumor heterogeneity. Furthermore, we discuss how these factors could be used to direct and optimize research efforts to improve patient care, focusing on therapeutic resistance. Finally, we emphasize the need for longitudinal studies to address the impact of these potential tumor heterogeneity-promoting factors on drug resistance, metastatic potential and clinical outcome. PMID:24267946

Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels.

PubMed

Chua, Song Lin; Ding, Yichen; Liu, Yang; Cai, Zhao; Zhou, Jianuan; Swarup, Sanjay; Drautz-Moses, Daniela I; Schuster, Stephan Christoph; Kjelleberg, Staffan; Givskov, Michael; Yang, Liang

2016-11-01

The host immune system offers a hostile environment with antimicrobials and reactive oxygen species (ROS) that are detrimental to bacterial pathogens, forcing them to adapt and evolve for survival. However, the contribution of oxidative stress to pathogen evolution remains elusive. Using an experimental evolution strategy, we show that exposure of the opportunistic pathogen Pseudomonas aeruginosa to sub-lethal hydrogen peroxide (H 2 O 2 ) levels over 120 generations led to the emergence of pro-biofilm rough small colony variants (RSCVs), which could be abrogated by l-glutathione antioxidants. Comparative genomic analysis of the RSCVs revealed that mutations in the wspF gene, which encodes for a repressor of WspR diguanylate cyclase (DGC), were responsible for increased intracellular cyclic-di-GMP content and production of Psl exopolysaccharide. Psl provides the first line of defence against ROS and macrophages, ensuring the survival fitness of RSCVs over wild-type P. aeruginosa Our study demonstrated that ROS is an essential driving force for the selection of pro-biofilm forming pathogenic variants. Understanding the fundamental mechanism of these genotypic and phenotypic adaptations will improve treatment strategies for combating chronic infections. © 2016 The Authors.

Evolutionary impact of transposable elements on genomic diversity and lineage-specific innovation in vertebrates.

PubMed

Warren, Ian A; Naville, Magali; Chalopin, Domitille; Levin, Perrine; Berger, Chloé Suzanne; Galiana, Delphine; Volff, Jean-Nicolas

2015-09-01

Since their discovery, a growing body of evidence has emerged demonstrating that transposable elements are important drivers of species diversity. These mobile elements exhibit a great variety in structure, size and mechanisms of transposition, making them important putative actors in organism evolution. The vertebrates represent a highly diverse and successful lineage that has adapted to a wide range of different environments. These animals also possess a rich repertoire of transposable elements, with highly diverse content between lineages and even between species. Here, we review how transposable elements are driving genomic diversity and lineage-specific innovation within vertebrates. We discuss the large differences in TE content between different vertebrate groups and then go on to look at how they affect organisms at a variety of levels: from the structure of chromosomes to their involvement in the regulation of gene expression, as well as in the formation and evolution of non-coding RNAs and protein-coding genes. In the process of doing this, we highlight how transposable elements have been involved in the evolution of some of the key innovations observed within the vertebrate lineage, driving the group's diversity and success.

An Effective Continuum Model for the Gas Evolution in Internal Steam Drives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsimpanogiannis, Ioannis N.; Yortsos, Yanis C.

This report examines the gas phase growth from a supersaturated, slightly compressible, liquid in a porous medium, driven by heat transfer and controlled by the application of a constant-rate decline of the system pressure.

Otolith shape lends support to the sensory drive hypothesis in rockfishes.

PubMed

Tuset, V M; Otero-Ferrer, J L; Gómez-Zurita, J; Venerus, L A; Stransky, C; Imondi, R; Orlov, A M; Ye, Z; Santschi, L; Afanasiev, P K; Zhuang, L; Farré, M; Love, M S; Lombarte, A

2016-10-01

The sensory drive hypothesis proposes that environmental factors affect both signalling dynamics and the evolution of signals and receivers. Sound detection and equilibrium in marine fishes are senses dependent on the sagittae otoliths, whose morphological variability appears intrinsically linked to the environment. The aim of this study was to understand if and which environmental factors could be conditioning the evolution of this sensory structure, therefore lending support to the sensory drive hypothesis. Thus, we analysed the otolith shape of 42 rockfish species (Sebastes spp.) to test the potential associations with the phylogeny, biological (age), ecological (feeding habit and depth distribution) and biogeographical factors. The results showed strong differences in the otolith shapes of some species, noticeably influenced by ecological and biogeographical factors. Moreover, otolith shape was clearly conditioned by phylogeny, but with a strong environmental effect, cautioning about the use of this structure for the systematics of rockfishes or other marine fishes. However, our most relevant finding is that the data supported the sensory drive hypothesis as a force promoting the radiation of the genus Sebastes. This hypothesis holds that adaptive divergence in communication has significant influence relative to other life history traits. It has already been established in Sebastes for visual characters and organs; our results showed that it applies to otolith transformations as well (despite the clear influence of feeding and depth), expanding the scope of the hypothesis to other sensory structures. © 2016 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2016 European Society For Evolutionary Biology.

Possible effects of depolarizing GABAA conductance on the neuronal input-output relationship: a modeling study.

PubMed

Morita, Kenji; Tsumoto, Kunichika; Aihara, Kazuyuki

2005-06-01

Recent in vitro experiments revealed that the GABAA reversal potential is about 10 mV higher than the resting potential in mature mammalian neocortical pyramidal cells; thus GABAergic inputs could have facilitatory, rather than inhibitory, effects on action potential generation under certain conditions. However, how the relationship between excitatory input conductances and the output firing rate is modulated by such depolarizing GABAergic inputs under in vivo circumstances has not yet been understood. We examine herewith the input-output relationship in a simple conductance-based model of cortical neurons with the depolarized GABAA reversal potential, and show that a tonic depolarizing GABAergic conductance up to a certain amount does not change the relationship between a tonic glutamatergic driving conductance and the output firing rate, whereas a higher GABAergic conductance prevents spike generation. When the tonic glutamatergic and GABAergic conductances are replaced by in vivo-like highly fluctuating inputs, on the other hand, the effect of depolarizing GABAergic inputs on the input-output relationship critically depends on the degree of coincidence between glutamatergic input events and GABAergic ones. Although a wide range of depolarizing GABAergic inputs hardly changes the firing rate of a neuron driven by noncoincident glutamatergic inputs, a certain range of these inputs considerably decreases the firing rate if a large number of driving glutamatergic inputs are coincident with them. These results raise the possibility that the depolarized GABAA reversal potential is not a paradoxical mystery, but is instead a sophisticated device for discriminative firing rate modulation.

76 FR 82306 - Draft Guidance for Industry on Use of Histology in Biomarker Qualification Studies; Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-30

... evolution and reversibility of morphologic changes. Because of the many variations in the practice of..., and other forms of information technology. This draft guidance refers to previously approved...

Time reversal and charge conjugation in an embedding quantum simulator.

PubMed

Zhang, Xiang; Shen, Yangchao; Zhang, Junhua; Casanova, Jorge; Lamata, Lucas; Solano, Enrique; Yung, Man-Hong; Zhang, Jing-Ning; Kim, Kihwan

2015-08-04

A quantum simulator is an important device that may soon outperform current classical computations. A basic arithmetic operation, the complex conjugate, however, is considered to be impossible to be implemented in such a quantum system due to the linear character of quantum mechanics. Here, we present the experimental quantum simulation of such an unphysical operation beyond the regime of unitary and dissipative evolutions through the embedding of a quantum dynamics in the electronic multilevels of a (171)Yb(+) ion. We perform time reversal and charge conjugation, which are paradigmatic examples of antiunitary symmetry operators, in the evolution of a Majorana equation without the tomographic knowledge of the evolving state. Thus, these operations can be applied regardless of the system size. Our approach offers the possibility to add unphysical operations to the toolbox of quantum simulation, and provides a route to efficiently compute otherwise intractable quantities, such as entanglement monotones.

Multiplex Reverse Transcription-PCR for Simultaneous Surveillance of Influenza A and B Viruses

PubMed Central

Zhou, Bin; Barnes, John R.; Sessions, October M.; Chou, Tsui-Wen; Wilson, Malania; Stark, Thomas J.; Volk, Michelle; Spirason, Natalie; Halpin, Rebecca A.; Kamaraj, Uma Sangumathi; Ding, Tao; Stockwell, Timothy B.; Ghedin, Elodie; Barr, Ian G.

2017-01-01

ABSTRACT Influenza A and B viruses are the causative agents of annual influenza epidemics that can be severe, and influenza A viruses intermittently cause pandemics. Sequence information from influenza virus genomes is instrumental in determining mechanisms underpinning antigenic evolution and antiviral resistance. However, due to sequence diversity and the dynamics of influenza virus evolution, rapid and high-throughput sequencing of influenza viruses remains a challenge. We developed a single-reaction influenza A/B virus (FluA/B) multiplex reverse transcription-PCR (RT-PCR) method that amplifies the most critical genomic segments (hemagglutinin [HA], neuraminidase [NA], and matrix [M]) of seasonal influenza A and B viruses for next-generation sequencing, regardless of viral type, subtype, or lineage. Herein, we demonstrate that the strategy is highly sensitive and robust. The strategy was validated on thousands of seasonal influenza A and B virus-positive specimens using multiple next-generation sequencing platforms. PMID:28978683

Time reversal and charge conjugation in an embedding quantum simulator

PubMed Central

Zhang, Xiang; Shen, Yangchao; Zhang, Junhua; Casanova, Jorge; Lamata, Lucas; Solano, Enrique; Yung, Man-Hong; Zhang, Jing-Ning; Kim, Kihwan

2015-01-01

A quantum simulator is an important device that may soon outperform current classical computations. A basic arithmetic operation, the complex conjugate, however, is considered to be impossible to be implemented in such a quantum system due to the linear character of quantum mechanics. Here, we present the experimental quantum simulation of such an unphysical operation beyond the regime of unitary and dissipative evolutions through the embedding of a quantum dynamics in the electronic multilevels of a 171Yb+ ion. We perform time reversal and charge conjugation, which are paradigmatic examples of antiunitary symmetry operators, in the evolution of a Majorana equation without the tomographic knowledge of the evolving state. Thus, these operations can be applied regardless of the system size. Our approach offers the possibility to add unphysical operations to the toolbox of quantum simulation, and provides a route to efficiently compute otherwise intractable quantities, such as entanglement monotones. PMID:26239028

GM foods: is there a way forward?

PubMed

Jones, Huw D

2015-08-01

There are many quality targets in cereals that could generate step-change improvements in nutritional or food-processing characteristics. For instance, levels of acrylamide, soluble and insoluble fibre, antioxidants, allergens and intolerance factors in food are, to a large extent, determined by the genetics of the raw materials used. However, improvements to these traits pose significant challenges to plant breeders. For some traits, this is because the underlying genetic and biochemical basis of the traits is not fully understood but for others, there is simply a lack of natural genetic variation in commercially useful germplasm. One strategy to overcome the latter hindrance is to use wide crosses with more exotic germplasm; however, this can bring other difficulties such as yield loss and linkage drag of deleterious alleles. As DNA sequencing becomes cheaper and faster, it drives the research fields of reverse genetics and functional genomics which in turn will enable the incorporation of desirable traits into crop varieties via molecular breeding and biotechnology. I will discuss the evolution of these techniques from conventional genetic modification to more recent developments in targeted gene editing and the potential of biotechnology to complement conventional breeding methods. I will also discuss the role of risk assessment and regulation in the commercialisation of GM crops.

Fast cooling for a system of stochastic oscillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yongxin, E-mail: chen2468@umn.edu; Georgiou, Tryphon T., E-mail: tryphon@umn.edu; Pavon, Michele, E-mail: pavon@math.unipd.it

2015-11-15

We study feedback control of coupled nonlinear stochastic oscillators in a force field. We first consider the problem of asymptotically driving the system to a desired steady state corresponding to reduced thermal noise. Among the feedback controls achieving the desired asymptotic transfer, we find that the most efficient one from an energy point of view is characterized by time-reversibility. We also extend the theory of Schrödinger bridges to this model, thereby steering the system in finite time and with minimum effort to a target steady-state distribution. The system can then be maintained in this state through the optimal steady-state feedbackmore » control. The solution, in the finite-horizon case, involves a space-time harmonic function φ, and −logφ plays the role of an artificial, time-varying potential in which the desired evolution occurs. This framework appears extremely general and flexible and can be viewed as a considerable generalization of existing active control strategies such as macromolecular cooling. In the case of a quadratic potential, the results assume a form particularly attractive from the algorithmic viewpoint as the optimal control can be computed via deterministic matricial differential equations. An example involving inertial particles illustrates both transient and steady state optimal feedback control.« less

Magnetic reversal frequency in the Lower Cambrian Niutitang Formation, Hunan Province, South China

NASA Astrophysics Data System (ADS)

Duan, Zongqi; Liu, Qingsong; Ren, Shoumai; Li, Lihui; Deng, Xiaolong; Liu, Jianxing

2018-05-01

The reversal frequency of the paleomagnetic field bears great information of evolution of the Earth's deep interior. However, there are still debates on the frequency pattern during the older periods of the Phanerozoic. This study investigated the Niutitang Formation (Lower Cambrian) of the Ciye 1 Hole from south China. Rock magnetic results indicate that the dominant magnetic carrier is magnetite. Characteristic remanence magnetizations have been successfully isolated for the weakly-magnetized shale rocks through stepwise alternated field demagnetization using the 2 G Enterprises Rapid System Magnetometer with a low-noise thin-walled quartz-glass sample holder. Constrained by radiometric ages, our paleomagnetic results indicated frequent polarity reversals during the period of ˜524-514 Ma, which backs up the speculation about the episode of the Ediacaran-Cambrian (˜550-500 Ma) with a character of reversal hyperactivity.

Illusion optics in chaotic light

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang Suheng; Gan Shu; Xiong Jun

2010-08-15

The time-reversal process provides the possibility to counteract the time evolution of a physical system. Recent research has shown that such a process can occur in the first-order field correlation of chaotic light and result in the spatial interference and phase-reversal diffraction in an unbalanced interferometer. Here we report experimental investigations on the invisibility cloak and illusion phenomena in chaotic light. In an unbalanced interferometer illuminated by thermal light, we have observed the cloak effect and the optical transformation of one object into another object. The experimental results can be understood by the phase-reversal diffraction, and they demonstrate the theoreticalmore » proposal of similar effects in complementary media.« less

Magnetospheric Substorm Evolution in the Magnetotail: Challenge to Global MHD Modeling.

NASA Astrophysics Data System (ADS)

Kuznetsova, M. M.; Hesse, M.; Dorelli, J.; Rastaetter, L.

2003-12-01

Testing the ability of global MHD models to describe magnetotail evolution during substroms is one of the elements of science based validation efforts at CCMC. We perform simulations of magnetotail dynamics using global MHD models residing at CCMC. We select solar wind conditions which drive the accumulation of magnetic field in the tail lobes and subsequent magnetic reconnection and energy release. We will analyze the effects of spatial resolution in the plasma sheet on modeled expansion phase evolution, maximum energy stored in the tail, and details of magnetotail reconnection. We will pay special attention to current sheet thinning and multiple plasmoid formation.

Origin and evolution of SINEs in eukaryotic genomes.

PubMed

Kramerov, D A; Vassetzky, N S

2011-12-01

Short interspersed elements (SINEs) are one of the two most prolific mobile genomic elements in most of the higher eukaryotes. Although their biology is still not thoroughly understood, unusual life cycle of these simple elements amplified as genomic parasites makes their evolution unique in many ways. In contrast to most genetic elements including other transposons, SINEs emerged de novo many times in evolution from available molecules (for example, tRNA). The involvement of reverse transcription in their amplification cycle, huge number of genomic copies and modular structure allow variation mechanisms in SINEs uncommon or rare in other genetic elements (module exchange between SINE families, dimerization, and so on.). Overall, SINE evolution includes their emergence, progressive optimization and counteraction to the cell's defense against mobile genetic elements.

A resonance based model of biological evolution

NASA Astrophysics Data System (ADS)

Damasco, Achille; Giuliani, Alessandro

2017-04-01

We propose a coarse grained physical model of evolution. The proposed model 'at least in principle' is amenable of an experimental verification even if this looks as a conundrum: evolution is a unique historical process and the tape cannot be reversed and played again. Nevertheless, we can imagine a phenomenological scenario tailored upon state transitions in physical chemistry in which different agents of evolution play the role of the elements of a state transition like thermal noise or resonance effects. The abstract model we propose can be of help for sketching hypotheses and getting rid of some well-known features of natural history like the so-called Cambrian explosion. The possibility of an experimental proof of the model is discussed as well.

Thermally driven microfluidic pumping via reversible shape memory polymers

NASA Astrophysics Data System (ADS)

Robertson, J. M.; Rodriguez, R. X.; Holmes, L. R., Jr.; Mather, P. T.; Wetzel, E. D.

2016-08-01

The need exists for autonomous microfluidic pumping systems that utilize environmental cues to transport fluid within a network of channels for such purposes as heat distribution, self-healing, or optical reconfiguration. Here, we report on reversible thermally driven microfluidic pumping enabled by two-way shape memory polymers. After developing a suitable shape memory polymer (SMP) through variation in the crosslink density, thin and flexible microfluidic devices were constructed by lamination of plastic films with channels defined by laser-cutting of double-sided adhesive film. SMP blisters integrated into the devices provide thermally driven pumping, while opposing elastic blisters are used to generate backpressure for reversible operation. Thermal cycling of the device was found to drive reversible fluid flow: upon heating to 60 °C, the SMP rapidly contracted to fill the surface channels with a transparent fluid, and upon cooling to 8 °C the flow reversed and the channel re-filled with black ink. Combined with a metallized backing layer, this device results in refection of incident light at high temperatures and absorption of light (at the portions covered with channels) at low temperatures. We discuss power-free, autonomous applications ranging from thermal regulation of structures to thermal indication via color change.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Z. X.; Wang, W. X.; Diamond, P. H.

We report that intrinsic torque, which can be generated by turbulent stresses, can induce toroidal rotation in a tokamak plasma at rest without direct momentum injection. Reversals in intrinsic torque have been inferred from the observation of toroidal velocity changes in recent lower hybrid current drive (LHCD) experiments. Here we focus on understanding the cause of LHCD-induced intrinsic torque reversal using gyrokinetic simulations and theoretical analyses. A new mechanism for the intrinsic torque reversal linked to magnetic shear (sˆ) effects on the turbulence spectrum is identified. This reversal is a consequence of the ballooning structure at weak sˆ . Basedmore » on realistic profiles from the Alcator C-Mod LHCD experiments, simulations demonstrate that the intrinsic torque reverses for weak sˆ discharges and that the value of sˆ crit is consistent with the experimental results sˆ exp crit [Rice et al., Phys. Rev. Lett. 111, 125003 (2013)]. In conclusion, the consideration of this intrinsic torque feature in our work is important for the understanding of rotation profile generation at weak and its consequent impact on macro-instability stabilization and micro-turbulence reduction, which is crucial for ITER. It is also relevant to internal transport barrier formation at negative or weakly positive sˆ .« less

Carbon and hydrogen isotopic reversals in deep basin gas: Evidence for limits to the stability of hydrocarbons

USGS Publications Warehouse

Burruss, R.C.; Laughrey, C.D.

2010-01-01

During studies of unconventional natural gas reservoirs of Silurian and Ordovician age in the northern Appalachian basin we observed complete reversal of the normal trend of carbon isotopic composition, such that ??13C methane (C1) >??13C ethane (C2) >??13C propane (C3). In addition, we have observed isotopic reversals in the ??2H in the deepest samples. Isotopic reversals cannot be explained by current models of hydrocarbon gas generation. Previous observations of partial isotopic reversals have been explained by mixing between gases from different sources and thermal maturities. We have constructed a model which, in addition to mixing, requires Rayleigh fractionation of C2 and C3 to cause enrichment in 13C and create reversals. In the deepest samples, the normal trend of increasing enrichment of 13C and 2H in methane with increasing depth reverses and 2H becomes depleted as 13C becomes enriched. We propose that the reactions that drive Rayleigh fractionation of C2 and C3 involve redox reactions with transition metals and water at late stages of catagenesis at temperatures on the order of 250-300??C. Published ab initio calculated fractionation factors for C-C bond breaking in ethane at these temperatures are consistent with our observations. The reversed trend in ??2H in methane appears to be caused by isotopic exchange with formation water at the same temperatures. Our interpretation that Rayleigh fractionation during redox reactions is causing isotopic reversals has important implications for natural gas resources in deeply buried sedimentary basins. ?? 2010.

Damage evolution during actuation fatigue in shape memory alloys (SPIE Best Student Paper Award)

NASA Astrophysics Data System (ADS)

Phillips, Francis R.; Wheeler, Robert; Lagoudas, Dimitris C.

2018-03-01

Shape Memory Alloys (SMAs) are unique materials able to undergo a thermomechanically induced, reversible phase transformation. Additionally, SMA are subject to two types of fatigue, that is structural fatigue due to cyclic loading as experienced by most materials, as well as actuation fatigue due to repeated thermally induced phase transformation. The evolution of multiple material characteristics is presented over the actuation fatigue lifetime of NiTiHf actuators, including the accumulation of irrecoverable strain, the evolution of internal voids, and the evolution of the effective modulus of the actuator. The results indicate that all three of these material characteristics are clearly interconnected and careful analysis of each of these characteristics can help to understand the evolution of the others, as well as help to understand how actuation fatigue leads to ultimate failure of the actuator.

GENERIC Integrators: Structure Preserving Time Integration for Thermodynamic Systems

NASA Astrophysics Data System (ADS)

Öttinger, Hans Christian

2018-04-01

Thermodynamically admissible evolution equations for non-equilibrium systems are known to possess a distinct mathematical structure. Within the GENERIC (general equation for the non-equilibrium reversible-irreversible coupling) framework of non-equilibrium thermodynamics, which is based on continuous time evolution, we investigate the possibility of preserving all the structural elements in time-discretized equations. Our approach, which follows Moser's [1] construction of symplectic integrators for Hamiltonian systems, is illustrated for the damped harmonic oscillator. Alternative approaches are sketched.

Mitochondria and the evolutionary roots of cancer

NASA Astrophysics Data System (ADS)

Davila, Alfonso F.; Zamorano, Pedro

2013-04-01

Cancer disease is inherent to, and widespread among, metazoans. Yet, some of the hallmarks of cancer such as uncontrolled cell proliferation, lack of apoptosis, hypoxia, fermentative metabolism and free cell motility (metastasis) are akin to a prokaryotic lifestyle, suggesting a link between cancer disease and evolution. In this hypothesis paper, we propose that cancer cells represent a phenotypic reversion to the earliest stage of eukaryotic evolution. This reversion is triggered by the dysregulation of the mitochondria due to cumulative oxidative damage to mitochondrial and nuclear DNA. As a result, the phenotype of normal, differentiated cells gradually reverts to the phenotype of a facultative anaerobic, heterotrophic cell optimized for survival and proliferation in hypoxic environments. This phenotype matches the phenotype of the last eukaryotic common ancestor (LECA) that resulted from the endosymbiosis between an α-proteobacteria (which later became the mitochondria) and an archaebacteria. As such, the evolution of cancer within one individual can be viewed as a recapitulation of the evolution of the eukaryotic cell from fully differentiated cells to LECA. This evolutionary model of cancer is compatible with the current understanding of the disease, and explains the evolutionary basis for most of the hallmarks of cancer, as well as the link between the disease and aging. It could also open new avenues for treatment directed at reestablishing the synergy between the mitochondria and the cancerous cell.

Repeated evolution and reversibility of self-fertilization in the volvocine green algae.

PubMed

Hanschen, Erik R; Herron, Matthew D; Wiens, John J; Nozaki, Hisayoshi; Michod, Richard E

2018-02-01

Outcrossing and self-fertilization are fundamental strategies of sexual reproduction, each with different evolutionary costs and benefits. Self-fertilization is thought to be an evolutionary "dead-end" strategy, beneficial in the short term but costly in the long term, resulting in self-fertilizing species that occupy only the tips of phylogenetic trees. Here, we use volvocine green algae to investigate the evolution of self-fertilization. We use ancestral-state reconstructions to show that self-fertilization has repeatedly evolved from outcrossing ancestors and that multiple reversals from selfing to outcrossing have occurred. We use three phylogenetic metrics to show that self-fertilization is not restricted to the tips of the phylogenetic tree, a finding inconsistent with the view of self-fertilization as a dead-end strategy. We also find no evidence for higher extinction rates or lower speciation rates in selfing lineages. We find that self-fertilizing species have significantly larger colonies than outcrossing species, suggesting the benefits of selfing may counteract the costs of increased size. We speculate that our macroevolutionary results on self-fertilization (i.e., non-tippy distribution, no decreased diversification rates) may be explained by the haploid-dominant life cycle that occurs in volvocine algae, which may alter the costs and benefits of selfing. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

Engineering the quantum states of light in a Kerr-nonlinear resonator by two-photon driving

NASA Astrophysics Data System (ADS)

Puri, Shruti; Boutin, Samuel; Blais, Alexandre

2017-04-01

Photonic cat states stored in high-Q resonators show great promise for hardware efficient universal quantum computing. We propose an approach to efficiently prepare such cat states in a Kerr-nonlinear resonator by the use of a two-photon drive. Significantly, we show that this preparation is robust against single-photon loss. An outcome of this observation is that a two-photon drive can eliminate undesirable phase evolution induced by a Kerr nonlinearity. By exploiting the concept of transitionless quantum driving, we moreover demonstrate how non-adiabatic initialization of cat states is possible. Finally, we present a universal set of quantum logical gates that can be performed on the engineered eigenspace of such a two-photon driven resonator and discuss a possible realization using superconducting circuits. The robustness of the engineered subspace to higher-order circuit nonlinearities makes this implementation favorable for scalable quantum computation.

Prethermal time crystals in a one-dimensional periodically driven Floquet system

NASA Astrophysics Data System (ADS)

Zeng, Tian-Sheng; Sheng, D. N.

2017-09-01

Motivated by experimental observations of time-symmetry breaking behavior in a periodically driven (Floquet) system, we study a one-dimensional spin model to explore the stability of such Floquet discrete time crystals (DTCs) under the interplay between interaction and the microwave driving. For intermediate interactions and high drivings, from the time evolution of both stroboscopic spin polarization and mutual information between two ends, we show that Floquet DTCs can exist in a prethermal time regime without the tuning of strong disorder. For much weak interactions the system is a symmetry-unbroken phase, while for strong interactions it gives its way to a thermal phase. Through analyzing the entanglement dynamics, we show that large driving fields protect the prethermal DTCs from many-body localization and thermalization. Our results suggest that by increasing the spin interaction, one can drive the experimental system into optimal regime for observing a robust prethermal DTC phase.

wtf genes are prolific dual poison-antidote meiotic drivers.

PubMed

Nuckolls, Nicole L; Bravo Núñez, María Angélica; Eickbush, Michael T; Young, Janet M; Lange, Jeffrey J; Yu, Jonathan S; Smith, Gerald R; Jaspersen, Sue L; Malik, Harmit S; Zanders, Sarah E

2017-06-20

Meiotic drivers are selfish genes that bias their transmission into gametes, defying Mendelian inheritance. Despite the significant impact of these genomic parasites on evolution and infertility, few meiotic drive loci have been identified or mechanistically characterized. Here, we demonstrate a complex landscape of meiotic drive genes on chromosome 3 of the fission yeasts Schizosaccharomyces kambucha and S. pombe . We identify S. kambucha wtf4 as one of these genes that acts to kill gametes (known as spores in yeast) that do not inherit the gene from heterozygotes. wtf4 utilizes dual, overlapping transcripts to encode both a gamete-killing poison and an antidote to the poison. To enact drive, all gametes are poisoned, whereas only those that inherit wtf4 are rescued by the antidote. Our work suggests that the wtf multigene family proliferated due to meiotic drive and highlights the power of selfish genes to shape genomes, even while imposing tremendous costs to fertility.

Transitionless driving on adiabatic search algorithm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oh, Sangchul, E-mail: soh@qf.org.qa; Kais, Sabre, E-mail: kais@purdue.edu; Department of Chemistry, Department of Physics and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907

We study quantum dynamics of the adiabatic search algorithm with the equivalent two-level system. Its adiabatic and non-adiabatic evolution is studied and visualized as trajectories of Bloch vectors on a Bloch sphere. We find the change in the non-adiabatic transition probability from exponential decay for the short running time to inverse-square decay in asymptotic running time. The scaling of the critical running time is expressed in terms of the Lambert W function. We derive the transitionless driving Hamiltonian for the adiabatic search algorithm, which makes a quantum state follow the adiabatic path. We demonstrate that a uniform transitionless driving Hamiltonian,more » approximate to the exact time-dependent driving Hamiltonian, can alter the non-adiabatic transition probability from the inverse square decay to the inverse fourth power decay with the running time. This may open up a new but simple way of speeding up adiabatic quantum dynamics.« less

Establishing a Geologic Baseline Of Cape Canaveral's Natural Landscape: Black Point Drive

NASA Technical Reports Server (NTRS)

Parkinson, Randall W.

2001-01-01

The goal of this project is to identify the process responsible for the formation of geomorphic features in the Black Point Drive area of Merritt Island National Wildlife Refuge/Kennedy Space Center (MINWR/KSC), northwest Cape Canaveral. This study confirms the principal landscape components (geomorphology) of Black Point Drive reflect interaction between surficial sediments deposited in association with late-Quaternary sea-level highstands and the chemical evolution of late-Cenozoic subsurface limestone formations. The Black Point Drive landscape consists of an undulatory mesic terrain which dips westward into myriad circular and channel-like depression marshes and lakes. This geomorphic gradient may reflect: (1) spatial distinctions in the elevation, character or age of buried (pre-Miocene) limestone formations, (2) dissolution history of late-Quaternary coquina and/or (3) thickness of unconsolidated surface sediment. More detailed evaluation of subsurface data will be necessary before this uncertainty can be resolved.

Establishing A Geologic Baseline of Cape Canaveral''s Natural Landscape: Black Point Drive

NASA Technical Reports Server (NTRS)

Parkinson, Randall W.

2002-01-01

The goal of this project is to identify the process responsible for the formation of geomorphic features in the Black Point Drive area of Merritt Island National Wildlife Refuge/Kennedy Space Center (MINWR/KSC), northwest Cape Canaveral. This study confirms the principal landscape components (geomorphology) of Black Point Drive reflect interaction between surficial sediments deposited in association with late-Quaternary sea-level highstands and the chemical evolution of late-Cenozoic sub-surface limestone formations. The Black Point Drive landscape consists of an undulatory mesic terrain which dips westward into myriad circular and channel-like depression marshes and lakes. This geomorphic gradient may reflect: (1) spatial distinctions in the elevation, character or age of buried (pre-Miocene) limestone formations, (2) dissolution history of late-Quaternary coquina and/or (3) thickness of unconsolidated surface sediment. More detailed evaluation of subsurface data will be necessary before this uncertain0 can be resolved.

The organization and evolution of the Responder satellite in species of the Drosophila melanogaster group: dynamic evolution of a target of meiotic drive.

PubMed

Larracuente, Amanda M

2014-11-25

Satellite DNA can make up a substantial fraction of eukaryotic genomes and has roles in genome structure and chromosome segregation. The rapid evolution of satellite DNA can contribute to genomic instability and genetic incompatibilities between species. Despite its ubiquity and its contribution to genome evolution, we currently know little about the dynamics of satellite DNA evolution. The Responder (Rsp) satellite DNA family is found in the pericentric heterochromatin of chromosome 2 of Drosophila melanogaster. Rsp is well-known for being the target of Segregation Distorter (SD)- an autosomal meiotic drive system in D. melanogaster. I present an evolutionary genetic analysis of the Rsp family of repeats in D. melanogaster and its closely-related species in the melanogaster group (D. simulans, D. sechellia, D. mauritiana, D. erecta, and D. yakuba) using a combination of available BAC sequences, whole genome shotgun Sanger reads, Illumina short read deep sequencing, and fluorescence in situ hybridization. I show that Rsp repeats have euchromatic locations throughout the D. melanogaster genome, that Rsp arrays show evidence for concerted evolution, and that Rsp repeats exist outside of D. melanogaster, in the melanogaster group. The repeats in these species are considerably diverged at the sequence level compared to D. melanogaster, and have a strikingly different genomic distribution, even between closely-related sister taxa. The genomic organization of the Rsp repeat in the D. melanogaster genome is complex-it exists of large blocks of tandem repeats in the heterochromatin and small blocks of tandem repeats in the euchromatin. My discovery of heterochromatic Rsp-like sequences outside of D. melanogaster suggests that SD evolved after its target satellite and that the evolution of the Rsp satellite family is highly dynamic over a short evolutionary time scale (<240,000 years).

Reversing Flows and Heat Spike: Caused by Solar g-Modes?

NASA Technical Reports Server (NTRS)

Mayr, Hans G.; Wolff, Charles L.

2003-01-01

The Quasi Biennial Oscillation in the Earth s upper atmosphere has an analog deep inside the Sun. As on Earth, the flow is east or west, it is at low latitude, and it reverses direction in a roughly periodic manner. The period in the solar case is 1.3 years. It was detected using solar oscillations similar to the way earthquakes are used to study the Earth's interior. But its cause was not known. We showed that global oscillations (g-modes) can supply enough angular momentum to drive zonal flows with the observed reversal period. This required a calculation of wave dissipation rates inside each flow and in the turbulent layer that separates any two flows of opposite sign. Heat that this process leaves behind causes a thermal spike inside the Sun at the same depth. This may explain an anomaly in observed sound speed that has had no sure explanation.

Crystal structures of HIV-1 nonnucleoside reverse transcriptase inhibitors: N-benzyl-4-methyl-benzimidazoles

NASA Astrophysics Data System (ADS)

Ziółkowska, Natasza E.; Michejda, Christopher J.; Bujacz, Grzegorz D.

2009-07-01

HIV-1 nonnucleoside reverse transcriptase inhibitors are potentially specific and effective drugs in AIDS therapy. The presence of two aromatic systems with an angled orientation in the molecule of the inhibitor is crucial for interactions with HIV-1 RT. The inhibitor drives like a wedge into the cluster of aromatic residues of RT HIV-1 and restrains the enzyme in a conformation that blocks the chemical step of nucleotide incorporation. Structural studies provide useful information for designing new, more active inhibitors. The crystal structures of four NNRTIs are presented here. The investigated compounds are derivatives of N-benzyl-4-methyl-benzimidazole with various aliphatic and aromatic substituents at carbon 2 positions and a 2,6-dihalogeno-substituted N-benzyl moiety. Structural data reported here show that the conformation of the investigated compounds is relatively rigid. Such feature is important for the nonnucleoside inhibitor binding to HIV-1 reverse transcriptase.

Dynamical and structural transitions in periodically-driven emulsions: Reversibility loss and random hyper-unifom organization

NASA Astrophysics Data System (ADS)

Weijs, Joost H.; Jeanneret, Raphaël; Dreyfus, Rémi; Bartolo, Denis

2015-03-01

We present experiments and numerical simulations of a microfluidic echo process, in which a large number of droplets interact in a periodically driven viscous fluid [Jeanneret & Bartolo, Nature Comm. 5, 3474 (2013)]. Upon increasing the driving amplitude we demonstrate the collective reversibility loss of the droplet dynamics. In addition we show that this genuine dynamical phase transition is associated with a structural one: at the onset of irreversibility the droplet ensemble self-organises into a random hyperuniform state. Numerical simulations evidence that the purely reversible hydrodynamic interactions together with hard-core repulsion account for most of our experimental findings. Hyperuniformity is relevant for the production of large-band-gap materials, but are difficult to construct both numerically and experimentally. The hydrodynamic echo-process may provide a robust, fast, and simple way to produce hyper uniform structures over a wide range of packing fractions.

Magnetohydrodynamic simulations of noninductive helicity injection in the reversed-field pinch and tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sovinec, Carl R.

1995-11-01

Numerical computation is used to investigate resistive magnetohydrodynamic (MHD) fluctuations in the reversed-field pinch (RFP) and in tokamak-like configurations driven solely by direct current (DC) helicity injection. A Lundquist number (S) scan of RFP turbulence without plasma pressure produces the weak scaling of S -0.18 for the root-mean-square magnetic fluctuation level for 2.5x10 3≤S≤4x10 4. The temporal behavior of fluctuations and the reversal parameter becomes more regular as S is increased, acquiring a "sawtooth" shape at the largest value of S. Simulations with plasma pressure and anisotropic thermal conduction demonstrate energy transport resulting from parallel heat fluctuations. To investigate meansmore » of improving RFP energy confinement, three forms of current profile modification are tested. Radio frequency (RF) current drive is modeled with an auxiliary electron force, and linear stability calculations are used.« less

Structural basis of reverse nucleotide polymerization

PubMed Central

Nakamura, Akiyoshi; Nemoto, Taiki; Heinemann, Ilka U.; Yamashita, Keitaro; Sonoda, Tomoyo; Komoda, Keisuke; Tanaka, Isao; Söll, Dieter; Yao, Min

2013-01-01

Nucleotide polymerization proceeds in the forward (5′-3′) direction. This tenet of the central dogma of molecular biology is found in diverse processes including transcription, reverse transcription, DNA replication, and even in lagging strand synthesis where reverse polymerization (3′-5′) would present a “simpler” solution. Interestingly, reverse (3′-5′) nucleotide addition is catalyzed by the tRNA maturation enzyme tRNAHis guanylyltransferase, a structural homolog of canonical forward polymerases. We present a Candida albicans tRNAHis guanylyltransferase-tRNAHis complex structure that reveals the structural basis of reverse polymerization. The directionality of nucleotide polymerization is determined by the orientation of approach of the nucleotide substrate. The tRNA substrate enters the enzyme’s active site from the opposite direction (180° flip) compared with similar nucleotide substrates of canonical 5′-3′ polymerases, and the finger domains are on opposing sides of the core palm domain. Structural, biochemical, and phylogenetic data indicate that reverse polymerization appeared early in evolution and resembles a mirror image of the forward process. PMID:24324136

Irreversible evolution of angular-dependent coercivity in Fe80Ni20 nanowire arrays: Detection of a single vortex state

NASA Astrophysics Data System (ADS)

Alikhani, M.; Ramazani, A.; Almasi Kashi, M.; Samanifar, S.; Montazer, A. H.

2016-09-01

The irreversible evolution of magnetic coercivity in arrays of 75 nm diameter Fe80Ni20 nanowires (NWs) has been explored by means of first-order reversal curve (FORC) analysis as a function of the angle between the magnetic field and the NW axis (0°≤θ≤90°). The Fe80Ni20 NWs with lengths up to 60 μm were fabricated using a pulsed electrodeposition method into hard-anodic aluminum oxide templates with an interpore distance of 275 nm. Investigating the interwire and intrawire magnetostatic interactions, the angular FORC (AFORC) diagrams indicated enhanced intrawire interactions with increasing length and θ (<90°), induced by a magnetization reversal through vortex domain wall (VDW) propagation. Intriguingly, in addition to the VDW mode, a single vortex state with broad irreversible switching of nucleation and annihilation fields was detected at θ=83° for 60 μm long NWs. At θ=90°, the NWs reversed magnetization through transverse domain wall, involving a reversible component by a fraction of 95%. Furthermore, the transition angle between the reversal modes was found to decrease with increasing aspect ratio from 200 to 800. The irreversible angular-dependent coercivity (HcIrrev(θ)) of Fe80Ni20 NWs was extracted from the AFORC measurements and compared with the major angular dependence of coercivity (HcMajor(θ)) obtained from the conventional hysteresis loop measurements. While HcMajor(θ) showed a non-monotonic behavior, HcIrrev(θ) constantly increased with increasing θ (<90°). On the other hand, using analytical models, a 93% agreement was obtained between the theoretical angular-dependent nucleation field and experimental HcIrrev(θ) for irreversible switching of VDW when 0°≤θ≤86°.

Testing the niche variation hypothesis with a measure of body condition

EPA Science Inventory

Individual variation and fitness are cornerstones of evolution by natural selection. The niche variation hypothesis (NVH) posits that when interspecific competition is relaxed, intraspecific competition should drive niche expansion by selection favoring use of novel resources. Po...

Evolution in translational science: Whither the CTSAs?

PubMed

FitzGerald, Garret A

2015-04-22

Clinical and Translational Science Awards-funded institutions are naturally equipped to drive research on human phenotyping and, in turn, shape the practice of precision medicine in the clinic of the future. Copyright © 2015, American Association for the Advancement of Science.

Trichinella spiralis: the evolution of adaptation and parasitism

USDA-ARS?s Scientific Manuscript database

Parasitism among nematodes has occurred in multiple, independent events. Deciphering processes that drive species diversity and adaptation are keys to understanding parasitism and advancing control strategies. Studies have been put forth on morphological and physiological aspects of parasitism and a...

Moored Observations of Internal Waves in Luzon Strait: 3-D Structure, Dissipation, and Evolution

DTIC Science & Technology

2016-03-01

Strait: 3-D Structure, Dissipation, and Evolution Matthew H. Alford Scripps Institution of Oceanography 9500 Gilman Drive, mail code 0213 La...during IWISE. This work is done in collaboration with Craig Lee (APL/UW), and Dan Rudnick and Shaun Johnston at Scripps Institution of Oceanography ...Y.J. Yang, M.-H. Chang, and Q. Li. 2011. From Luzon Strait to Dongsha Plateau: Stages in the life of an internal wave. Oceanography 24(4):64–77

OBSCURED STAR FORMATION AND ENVIRONMENT IN THE COSMOS FIELD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feruglio, C.; Aussel, H.; Le Floc'h, E.

2010-09-20

We investigate the effects of the environment on star formation in a sample of massive luminous and ultra-luminous infrared galaxies (LIRGs and ULIRGs) with S(24 {mu}m) >80 {mu}Jy and i {sup +} < 24 in the COSMOS field. We exploit the accurate photometric redshifts in COSMOS to characterize the galaxy environment and study the evolution of the fraction of LIRGs and ULIRGs in different environments in the redshift range z = 0.3-1.2 and in bins of stellar mass. We find that the environment plays a role in the star formation processes and evolution of LIRGs and ULIRGs. We find anmore » overall increase of the ULIRG+LIRG fraction in an optically selected sample with increasing redshift, as expected from the evolution of the star formation rate (SFR) density. We find that the ULIRG+LIRG fraction decreases with increasing density up to z {approx} 1, and that the dependence on density flattens with increasing redshift. We do not observe the reversal of the SFR density relation up to z = 1 in massive LIRGs and ULIRGs, suggesting that such reversal might occur at higher redshift in this infrared luminosity range.« less

Sex Chromosome Drive

PubMed Central

Helleu, Quentin; Gérard, Pierre R.; Montchamp-Moreau, Catherine

2015-01-01

Sex chromosome drivers are selfish elements that subvert Mendel's first law of segregation and therefore are overrepresented among the products of meiosis. The sex-biased progeny produced then fuels an extended genetic conflict between the driver and the rest of the genome. Many examples of sex chromosome drive are known, but the occurrence of this phenomenon is probably largely underestimated because of the difficulty to detect it. Remarkably, nearly all sex chromosome drivers are found in two clades, Rodentia and Diptera. Although very little is known about the molecular and cellular mechanisms of drive, epigenetic processes such as chromatin regulation could be involved in many instances. Yet, its evolutionary consequences are far-reaching, from the evolution of mating systems and sex determination to the emergence of new species. PMID:25524548

The double-edged sword: How evolution can make or break a live-attenuated virus vaccine

PubMed Central

Hanley, Kathryn A.

2012-01-01

Even students who reject evolution are often willing to consider cases in which evolutionary biology contributes to, or undermines, biomedical interventions. Moreover the intersection of evolutionary biology and biomedicine is fascinating in its own right. This review offers an overview of the ways in which evolution has impacted the design and deployment of live-attenuated virus vaccines, with subsections that may be useful as lecture material or as the basis for case studies in classes at a variety of levels. Live- attenuated virus vaccines have been modified in ways that restrain their replication in a host, so that infection (vaccination) produces immunity but not disease. Applied evolution, in the form of serial passage in novel host cells, is a “classical” method to generate live-attenuated viruses. However many live-attenuated vaccines exhibit reversion to virulence through back-mutation of attenuating mutations, compensatory mutations elsewhere in the genome, recombination or reassortment, or changes in quasispecies diversity. Additionally the combination of multiple live-attenuated strains may result in competition or facilitation between individual vaccine viruses, resulting in undesirable increases in virulence or decreases in immunogenicity. Genetic engineering informed by evolutionary thinking has led to a number of novel approaches to generate live-attenuated virus vaccines that contain substantial safeguards against reversion to virulence and that ameliorate interference among multiple vaccine strains. Finally, vaccines have the potential to shape the evolution of their wild type counterparts in counter-productive ways; at the extreme vaccine-driven eradication of a virus may create an empty niche that promotes the emergence of new viral pathogens. PMID:22468165

Stabilizing multicellularity through ratcheting

PubMed Central

Libby, Eric; Conlin, Peter L.; Kerr, Ben; Ratcliff, William C.

2016-01-01

The evolutionary transition to multicellularity probably began with the formation of simple undifferentiated cellular groups. Such groups evolve readily in diverse lineages of extant unicellular taxa, suggesting that there are few genetic barriers to this first key step. This may act as a double-edged sword: labile transitions between unicellular and multicellular states may facilitate the evolution of simple multicellularity, but reversion to a unicellular state may inhibit the evolution of increased complexity. In this paper, we examine how multicellular adaptations can act as evolutionary ‘ratchets’, limiting the potential for reversion to unicellularity. We consider a nascent multicellular lineage growing in an environment that varies between favouring multicellularity and favouring unicellularity. The first type of ratcheting mutations increase cell-level fitness in a multicellular context but are costly in a single-celled context, reducing the fitness of revertants. The second type of ratcheting mutations directly decrease the probability that a mutation will result in reversion (either as a pleiotropic consequence or via direct modification of switch rates). We show that both types of ratcheting mutations act to stabilize the multicellular state. We also identify synergistic effects between the two types of ratcheting mutations in which the presence of one creates the selective conditions favouring the other. Ratcheting mutations may play a key role in diverse evolutionary transitions in individuality, sustaining selection on the new higher-level organism by constraining evolutionary reversion. This article is part of the themed issue ‘The major synthetic evolutionary transitions’. PMID:27431522

Minimizing losses by variational counter-diabatic driving

NASA Astrophysics Data System (ADS)

Sels, Dries; Polkovnikov, Anatoli

Despite the time-reversal symmetry of the microscopic dynamics of isolated systems, losses are ubiquitous in any process that tries to manipulate them. Whether it's the heat produced in a car engine or the decoherence of a qubit, all losses arise from our lack of control on the microscopic degrees of freedom of the system. Counter-diabatic driving protocols were proposed as a means to do fast changes in the Hamiltonian without exciting transitions. Such driving in principle allows one to realize arbitrarily fast annealing protocols or implement fast dissipationless driving, circumventing standard adiabatic limitations requiring infinitesimally slow rates. These ideas were tested and used both experimentally and theoretically in small systems, but in larger chaotic systems it is known that exact counter-diabatic protocols do not exist. Here we will present a simple variational approach allowing one to find best physical counter-diabatic protocols. We will show that, while they do not get rid of all transitions, the variational protocols are able to significantly reduce the induced fluctuations in the system. D.S. acknowledges support by the FWO.

Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?

PubMed Central

Macias, Vanessa M.; Ohm, Johanna R.; Rasgon, Jason L.

2017-01-01

Mosquito-borne pathogens place an enormous burden on human health. The existing toolkit is insufficient to support ongoing vector-control efforts towards meeting disease elimination and eradication goals. The perspective that genetic approaches can potentially add a significant set of tools toward mosquito control is not new, but the recent improvements in site-specific gene editing with CRISPR/Cas9 systems have enhanced our ability to both study mosquito biology using reverse genetics and produce genetics-based tools. Cas9-mediated gene-editing is an efficient and adaptable platform for gene drive strategies, which have advantages over innundative release strategies for introgressing desirable suppression and pathogen-blocking genotypes into wild mosquito populations; until recently, an effective gene drive has been largely out of reach. Many considerations will inform the effective use of new genetic tools, including gene drives. Here we review the lengthy history of genetic advances in mosquito biology and discuss both the impact of efficient site-specific gene editing on vector biology and the resulting potential to deploy new genetic tools for the abatement of mosquito-borne disease. PMID:28869513

Paleomagnetism of the Cretaceous Galula Formation and implications for vertebrate evolution

NASA Astrophysics Data System (ADS)

Widlansky, Sarah J.; Clyde, William C.; O'Connor, Patrick M.; Roberts, Eric M.; Stevens, Nancy J.

2018-03-01

This study uses magnetostratigraphy to help constrain the age of the paleontologically important Galula Formation (Rukwa Rift Basin, southwestern Tanzania). The formation preserves a Cretaceous vertebrate fauna, including saurischian dinosaurs, a putative gondwanatherian mammal, and notosuchian crocodyliforms. With better dating, the Galula Formation and its fossils help fill a temporal gap in our understanding of vertebrate evolution in continental Africa, enabling better evaluation of competing paleobiogeographic hypotheses concerning faunal exchange throughout Gondwana during the Cretaceous. Paleomagnetic samples for this study were collected from the Namba (higher in section) and Mtuka (lower in section) members of the Galula Formation and underwent stepwise thermal demagnetization. All samples displayed a strong normal magnetic polarity overprint, and maximum unblocking temperatures at approximately 690 °C. Three short reversed intervals were identified in the Namba Member, whereas the Mtuka Member lacked any clear reversals. Given the relatively limited existing age constraints, one interpretation correlates the Namba Member to Chron C32. An alternative correlation assigns reversals in the Namba Member to recently proposed short reversals near the end of the Cretaceous Normal Superchron (Chron C34), a time that is traditionally interpreted as having stable normal polarity. The lack of reversals in the Mtuka Member supports deposition within Chron C34. These data suggest that the Namba Member is no older than Late Cretaceous (Cenomanian-Campanian), with the Mtuka Member less well constrained to the middle Cretaceous (Aptian-Cenomanian). The paleomagnetic results are supported by the application of fold and reversal tests for paleomagnetic stability, and paleomagnetic poles for the Namba (246.4°/77.9°, α95 5.9°) and Mtuka (217.1°/72.2°, α95 11.1°) members closely matching the apparent polar wander path for Africa during the Late Cretaceous. These results confidently indicate a Late Creteceous age assignment for the Namba Member of the Galula Formation, a unit that has yielded key crocodyliform (e.g., Pakasuchus; Rukwasuchus) and dinosaur (e.g., Rukwatitan; Shingopana) fossils from eastern Africa.

Directed evolution and synthetic biology applications to microbial systems.

PubMed

Bassalo, Marcelo C; Liu, Rongming; Gill, Ryan T

2016-06-01

Biotechnology applications require engineering complex multi-genic traits. The lack of knowledge on the genetic basis of complex phenotypes restricts our ability to rationally engineer them. However, complex phenotypes can be engineered at the systems level, utilizing directed evolution strategies that drive whole biological systems toward desired phenotypes without requiring prior knowledge of the genetic basis of the targeted trait. Recent developments in the synthetic biology field accelerates the directed evolution cycle, facilitating engineering of increasingly complex traits in biological systems. In this review, we summarize some of the most recent advances in directed evolution and synthetic biology that allows engineering of complex traits in microbial systems. Then, we discuss applications that can be achieved through engineering at the systems level. Copyright © 2016 Elsevier Ltd. All rights reserved.

Integrating Competition for Food, Hosts, or Mates via Experimental Evolution.

PubMed

Rodrigues, Leonor R; Duncan, Alison B; Clemente, Salomé H; Moya-Laraño, Jordi; Magalhães, Sara

2016-02-01

Competitive interactions shape the evolution of organisms. However, often it is not clear whether competition is the driving force behind the patterns observed. The recent use of experimental evolution in competitive environments can help establish such causality. Unfortunately, this literature is scattered, as competition for food, mates, and hosts are subject areas that belong to different research fields. Here, we group these bodies of literature, extract common processes and patterns concerning the role of competition in shaping evolutionary trajectories, and suggest perspectives stemming from an integrative view of competition across these research fields. This review reinstates the power of experimental evolution in addressing the evolutionary consequences of competition, but highlights potential pitfalls in the design of such experiments. Copyright © 2015 Elsevier Ltd. All rights reserved.

Pathogen evolution and the immunological niche

PubMed Central

Cobey, Sarah

2014-01-01

Host immunity is a major driver of pathogen evolution and thus a major determinant of pathogen diversity. Explanations for pathogen diversity traditionally assume simple interactions between pathogens and the immune system, a view encapsulated by the susceptible–infected–recovered (SIR) model. However, there is growing evidence that the complexity of many host–pathogen interactions is dynamically important. This revised perspective requires broadening the definition of a pathogen's immunological phenotype, or what can be thought of as its immunological niche. After reviewing evidence that interactions between pathogens and host immunity drive much of pathogen evolution, I introduce the concept of a pathogen's immunological phenotype. Models that depart from the SIR paradigm demonstrate the utility of this perspective and show that it is particularly useful in understanding vaccine-induced evolution. This paper highlights questions in immunology, evolution, and ecology that must be answered to advance theories of pathogen diversity. PMID:25040161

Synergy from reproductive division of labor and genetic complexity drive the evolution of sex.

PubMed

Jaffe, Klaus

2018-04-16

Computer experiments that mirror the evolutionary dynamics of sexual and asexual organisms as they occur in nature were used to test features proposed to explain the evolution of sexual recombination. Results show that this evolution is better described as a network of interactions between possible sexual forms, including diploidy, thelytoky, facultative sex, assortation, bisexuality, and division of labor between the sexes, rather than a simple transition from parthenogenesis to sexual recombination. Diploidy was shown to be fundamental for the evolution of sex; bisexual reproduction emerged only among anisogamic diploids with a synergistic division of reproductive labor; and facultative sex was more likely to evolve among haploids practicing assortative mating. Looking at the evolution of sex as a complex system through individual-based simulations explains better the diversity of sexual strategies known to exist in nature, compared to classical analytical models.

Solar Radiation as Driving Force In Early Evolution

NASA Technical Reports Server (NTRS)

Rothschild, Lynn J.; Peterson, David L. (Technical Monitor)

2002-01-01

Ultraviolet radiation (UVR) has provided an evolutionary challenge to life on Earth in that it is both an agent of mutation and as well as a selective force. Today surface fluxes of UVR vary diurnally, seasonally, etc. Still, the UVR flux was probably substantially higher during the early phases of evolution, suggesting that its role in evolution was even more prominent during this time. In this presentation, the creative role of UVR in evolution is discussed, specifically in connection with the role that UVR may have played in the evolution of early microbial ecosystems. The presentation will include discussions of the direct influence of UVR on such processes as photosynthesis and genetic damage, as well as the indirect influence of UVR as mediated through the production of reactive oxygen species. These biological effects of UVR will be viewed against the backdrop of the physical nature of the early Earth, surely a very different place then than now.

Predictable transcriptome evolution in the convergent and complex bioluminescent organs of squid

PubMed Central

Pankey, M. Sabrina; Minin, Vladimir N.; Imholte, Greg C.; Suchard, Marc A.; Oakley, Todd H.

2014-01-01

Despite contingency in life’s history, the similarity of evolutionarily convergent traits may represent predictable solutions to common conditions. However, the extent to which overall gene expression levels (transcriptomes) underlying convergent traits are themselves convergent remains largely unexplored. Here, we show strong statistical support for convergent evolutionary origins and massively parallel evolution of the entire transcriptomes in symbiotic bioluminescent organs (bacterial photophores) from two divergent squid species. The gene expression similarities are so strong that regression models of one species’ photophore can predict organ identity of a distantly related photophore from gene expression levels alone. Our results point to widespread parallel changes in gene expression evolution associated with convergent origins of complex organs. Therefore, predictable solutions may drive not only the evolution of novel, complex organs but also the evolution of overall gene expression levels that underlie them. PMID:25336755

Rapid neo-sex chromosome evolution and incipient speciation in a major forest pest.

PubMed

Bracewell, Ryan R; Bentz, Barbara J; Sullivan, Brian T; Good, Jeffrey M

2017-11-17

Genome evolution is predicted to be rapid following the establishment of new (neo) sex chromosomes, but it is not known if neo-sex chromosome evolution plays an important role in speciation. Here we combine extensive crossing experiments with population and functional genomic data to examine neo-XY chromosome evolution and incipient speciation in the mountain pine beetle. We find a broad continuum of intrinsic incompatibilities in hybrid males that increase in strength with geographic distance between reproductively isolated populations. This striking progression of reproductive isolation is coupled with extensive gene specialization, natural selection, and elevated genetic differentiation on both sex chromosomes. Closely related populations isolated by hybrid male sterility also show fixation of alternative neo-Y haplotypes that differ in structure and male-specific gene content. Our results suggest that neo-sex chromosome evolution can drive rapid functional divergence between closely related populations irrespective of ecological drivers of divergence.

Natural selection and the predictability of evolution in Timema stick insects.

PubMed

Nosil, Patrik; Villoutreix, Romain; de Carvalho, Clarissa F; Farkas, Timothy E; Soria-Carrasco, Víctor; Feder, Jeffrey L; Crespi, Bernard J; Gompert, Zach

2018-02-16

Predicting evolution remains difficult. We studied the evolution of cryptic body coloration and pattern in a stick insect using 25 years of field data, experiments, and genomics. We found that evolution is more difficult to predict when it involves a balance between multiple selective factors and uncertainty in environmental conditions than when it involves feedback loops that cause consistent back-and-forth fluctuations. Specifically, changes in color-morph frequencies are modestly predictable through time ( r 2 = 0.14) and driven by complex selective regimes and yearly fluctuations in climate. In contrast, temporal changes in pattern-morph frequencies are highly predictable due to negative frequency-dependent selection ( r 2 = 0.86). For both traits, however, natural selection drives evolution around a dynamic equilibrium, providing some predictability to the process. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Evolution and Reduction of Scour around Offshore Wind Turbines

NASA Astrophysics Data System (ADS)

McGovern, David; Ilic, Suzana

2010-05-01

Evolution and Reduction of Scour around Offshore Wind Turbines In response to growing socio-economic and environmental demands, electricity generation through offshore wind turbine farms is a fast growing sector of the renewable energy market. Considerable numbers of offshore wind farms exist in the shallow continental shelf seas of the North-West Europe, with many more in the planning stages. Wind energy is harnessed by large rotating blades that drive an electricity generating turbine placed on top of a long cylindrical monopile that are driven into the sea-bed, well into the bed rock below the sediment. Offshore wind turbines are popular due to consistently higher wind speeds and lower visual impact than their onshore counter parts, but their construction and maintenance is not without its difficulties. The alteration of flow by the presence of the wind turbine monopile results in changes in sedimentary processes and morphology at its base. The increase in flow velocity and turbulence causes an amplification of bed shear stress and this can result in the creation of a large scour hole at the monopile base. Such a scour hole can adversely affect the structural integrity and hence longevity of the monopile. Changes to the sea bed caused by this may also locally affect the benthic habitat. We conducted an extensive series of rigid and mobile bed experiments to examine the process of scour under tidal currents. We also test the effectiveness of a flow-altering collared monopile in reducing scour. Firstly, we used Particle Image Velocimetry (PIV) and Acoustic Doppler Velocimetry (ADV) to visualise and analyse the flow and turbulence properties in the local flow around the monopile and collared monopile over a smooth rigid bed under tidal flow. The measured flow, turbulence and shear stress properties are related to mobile bed tests where a Seatek 5 MHz Ultrasonic Ranging system is used to identify the evolution of scour under reversing tidal currents. The tidal evolution of the scour hole around the monopile is compared with that under unidirectional currents and that around the collared monopile. Results show that the evolution of scour under tidal currents is quite different than that of a unidirectional current and that the scour hole shape is also more symmetrical than the scour hole under a unidirectional current, which is quite asymmetrical. Results also indicate that the collared monopile design is effective in reducing the depth of scour that occurs at its base. This data will also be used for a validation of the numerical model of scour processes around the pile. Key words: Monopile, Scour, Tidal Flow, Scour Reduction

Hydrogen storage and evolution catalysed by metal hydride complexes.

PubMed

Fukuzumi, Shunichi; Suenobu, Tomoyoshi

2013-01-07

The storage and evolution of hydrogen are catalysed by appropriate metal hydride complexes. Hydrogenation of carbon dioxide by hydrogen is catalysed by a [C,N] cyclometalated organoiridium complex, [Ir(III)(Cp*)(4-(1H-pyrazol-1-yl-κN(2))benzoic acid-κC(3))(OH(2))](2)SO(4) [Ir-OH(2)](2)SO(4), under atmospheric pressure of H(2) and CO(2) in weakly basic water (pH 7.5) at room temperature. The reverse reaction, i.e., hydrogen evolution from formate, is also catalysed by [Ir-OH(2)](+) in acidic water (pH 2.8) at room temperature. Thus, interconversion between hydrogen and formic acid in water at ambient temperature and pressure has been achieved by using [Ir-OH(2)](+) as an efficient catalyst in both directions depending on pH. The Ir complex [Ir-OH(2)](+) also catalyses regioselective hydrogenation of the oxidised form of β-nicotinamide adenine dinucleotide (NAD(+)) to produce the 1,4-reduced form (NADH) under atmospheric pressure of H(2) at room temperature in weakly basic water. In weakly acidic water, the complex [Ir-OH(2)](+) also catalyses the reverse reaction, i.e., hydrogen evolution from NADH to produce NAD(+) at room temperature. Thus, interconversion between NADH (and H(+)) and NAD(+) (and H(2)) has also been achieved by using [Ir-OH(2)](+) as an efficient catalyst and by changing pH. The iridium hydride complex formed by the reduction of [Ir-OH(2)](+) by H(2) and NADH is responsible for the hydrogen evolution. Photoirradiation (λ > 330 nm) of an aqueous solution of the Ir-hydride complex produced by the reduction of [Ir-OH(2)](+) with alcohols resulted in the quantitative conversion to a unique [C,C] cyclometalated Ir-hydride complex, which can catalyse hydrogen evolution from alcohols in a basic aqueous solution (pH 11.9). The catalytic mechanisms of the hydrogen storage and evolution are discussed by focusing on the reactivity of Ir-hydride complexes.

Detecting and Quantifying Mind Wandering during Simulated Driving.

PubMed

Baldwin, Carryl L; Roberts, Daniel M; Barragan, Daniela; Lee, John D; Lerner, Neil; Higgins, James S

2017-01-01

Mind wandering is a pervasive threat to transportation safety, potentially accounting for a substantial number of crashes and fatalities. In the current study, mind wandering was induced through completion of the same task for 5 days, consisting of a 20-min monotonous freeway-driving scenario, a cognitive depletion task, and a repetition of the 20-min driving scenario driven in the reverse direction. Participants were periodically probed with auditory tones to self-report whether they were mind wandering or focused on the driving task. Self-reported mind wandering frequency was high, and did not statistically change over days of participation. For measures of driving performance, participant labeled periods of mind wandering were associated with reduced speed and reduced lane variability, in comparison to periods of on task performance. For measures of electrophysiology, periods of mind wandering were associated with increased power in the alpha band of the electroencephalogram (EEG), as well as a reduction in the magnitude of the P3a component of the event related potential (ERP) in response to the auditory probe. Results support that mind wandering has an impact on driving performance and the associated change in driver's attentional state is detectable in underlying brain physiology. Further, results suggest that detecting the internal cognitive state of humans is possible in a continuous task such as automobile driving. Identifying periods of likely mind wandering could serve as a useful research tool for assessment of driver attention, and could potentially lead to future in-vehicle safety countermeasures.

Detecting and Quantifying Mind Wandering during Simulated Driving

PubMed Central

Baldwin, Carryl L.; Roberts, Daniel M.; Barragan, Daniela; Lee, John D.; Lerner, Neil; Higgins, James S.

2017-01-01

Mind wandering is a pervasive threat to transportation safety, potentially accounting for a substantial number of crashes and fatalities. In the current study, mind wandering was induced through completion of the same task for 5 days, consisting of a 20-min monotonous freeway-driving scenario, a cognitive depletion task, and a repetition of the 20-min driving scenario driven in the reverse direction. Participants were periodically probed with auditory tones to self-report whether they were mind wandering or focused on the driving task. Self-reported mind wandering frequency was high, and did not statistically change over days of participation. For measures of driving performance, participant labeled periods of mind wandering were associated with reduced speed and reduced lane variability, in comparison to periods of on task performance. For measures of electrophysiology, periods of mind wandering were associated with increased power in the alpha band of the electroencephalogram (EEG), as well as a reduction in the magnitude of the P3a component of the event related potential (ERP) in response to the auditory probe. Results support that mind wandering has an impact on driving performance and the associated change in driver’s attentional state is detectable in underlying brain physiology. Further, results suggest that detecting the internal cognitive state of humans is possible in a continuous task such as automobile driving. Identifying periods of likely mind wandering could serve as a useful research tool for assessment of driver attention, and could potentially lead to future in-vehicle safety countermeasures. PMID:28848414

Does the Tempo of Music Impact Human Behavior Behind the Wheel?

PubMed

Navarro, Jordan; Osiurak, François; Reynaud, Emanuelle

2018-06-01

Assess the influence of background music tempo on driving performance. Music with a fast tempo is known to increase the level of arousal, whereas the reverse is observed for slow music. The relationship between driving performance and level of arousal was expected to take the form of an inverted U-curve. Three experiments were undertaken to manipulate the musical background during driving. In Experiment 1, the driver's preferred music track played at its original and modified (plus or minus 30%) tempo were used together with the simple ticking of a metronome. In Experiment 2, music tracks of different tempos were played during driving. In Experiment 3, music tracks were categorized as arousing or relaxing based on the associated perceived level of arousal. Listening to music tended to influence drivers' performances in a car-following task by improving coherence and gain adjustments relative to the followed vehicle but simultaneously shortened the intervehicular time. Although the tempo of the music per se did not directly affect driving behavior, arousing music tracks improved drivers' adjustments to the followed vehicle (Experiment 3). The tempo of the music listened to behind the wheel was not found to influence driving behaviors. However, arousing music improved drivers' responsiveness to changes in the speed of the followed vehicle. However, this benefit was canceled out by a reduction in the drivers' intervehicle safety margin. Listening to arousing music while driving cannot be considered to improve road safety, at least in a car-following task without attentional impairments.

Transmission with a first-stage hydrostatic mode and two hydromechanical stages

DOEpatents

Orshansky, Jr., deceased, Elias; Weseloh, William E.

1981-01-01

A power transmission having two planetary assemblies, each having at least one carrier with planet gears, at least one sun gear, and at least one ring gear. A speed-varying module is connected in driving relation to the input shaft and in driving relationship to the sun gear or gears of the first planetary assembly. The speed-varying means may comprise a pair of hydraulic units hydraulically interconnected so that one serves as a pump while the other serves as a motor and vice versa, one of the units having a variable stroke and being connected in driving relation to the input shaft, the other unit, which may have a fixed stroke, being connected in driving relation to the sun gear. The input shaft is also connected directly to a sun gear of the second planetary assembly and is further connectable by a clutch to a carrier of the first planetary assembly. Another clutch enables connecting the carrier of the first planetary assembly to a ring gear of the second planetary assembly. A brake grounds the first carrier in the first range and in reverse and causes drive to be delivered to the output through a ring gear of the first planetary assembly in a hydrostatic mode. The carrier of the second planetary assembly is connected in rigid driving relationship to that first ring gear, and in all ranges these two elements transmit the drive to the output shaft.

Hydromechanical transmission with three simple planetary assemblies, one sun gear being mounted on the output shaft and the other two on a common shaft connected to an input-driven hydraulic module

DOEpatents

Orshansky, Jr., deceased, Elias; Weseloh, William E.

1978-01-01

A power transmission having three simple planetary assemblies, each having its own carrier and its own planet, sun, and ring gears. A speed-varying module is connected in driving relation to the input shaft and in driving relationship to the sun gears of the first two planetary assemblies, these two sun gears being connected together on a common shaft. The speed-varying means may comprise a pair of hydraulic units hydraulically interconnected so that one serves as a pump while the other serves as a motor and vice versa, one of the units having a variable stroke and being connected in driving relation to the input shaft, the other unit, which may have a fixed stroke, being connected in driving relation to the sun gears. The input shaft is also connected to drive the second ring gear and, furthermore is clutchable to the carrier of the third planetary assembly. A brake grounds the first carrier in the first range and in reverse and causes drive to be delivered to the output through the first ring gear in a hydrostatic mode. The carrier of the second planetary assembly drives the ring gear of the third planetary assembly, which is clutchable to the output shaft, and the sun gear of the third planetary assembly is mounted rigidly to the output shaft.

Dodging silver bullets: good CRISPR gene-drive design is critical for eradicating exotic vertebrates.

PubMed

Prowse, Thomas A A; Cassey, Phillip; Ross, Joshua V; Pfitzner, Chandran; Wittmann, Talia A; Thomas, Paul

2017-08-16

Self-replicating gene drives that can spread deleterious alleles through animal populations have been promoted as a much needed but controversial 'silver bullet' for controlling invasive alien species. Homing-based drives comprise an endonuclease and a guide RNA (gRNA) that are replicated during meiosis via homologous recombination. However, their efficacy for controlling wild populations is threatened by inherent polymorphic resistance and the creation of resistance alleles via non-homologous end-joining (NHEJ)-mediated DNA repair. We used stochastic individual-based models to identify realistic gene-drive strategies capable of eradicating vertebrate pest populations (mice, rats and rabbits) on islands. One popular strategy, a sex-reversing drive that converts heterozygous females into sterile males, failed to spread and required the ongoing deployment of gene-drive carriers to achieve eradication. Under alternative strategies, multiplexed gRNAs could overcome inherent polymorphic resistance and were required for eradication success even when the probability of NHEJ was low. Strategies causing homozygotic embryonic non-viability or homozygotic female sterility produced high probabilities of eradication and were robust to NHEJ-mediated deletion of the DNA sequence between multiplexed endonuclease recognition sites. The latter two strategies also purged the gene drive when eradication failed, therefore posing lower long-term risk should animals escape beyond target islands. Multiplexing gRNAs will be necessary if this technology is to be useful for insular extirpation attempts; however, precise knowledge of homing rates will be required to design low-risk gene drives with high probabilities of eradication success. © 2017 The Author(s).

Electron-cyclotron wave propagation, absorption and current drive in the presence of neoclassical tearing modes

NASA Astrophysics Data System (ADS)

Isliker, Heinz; Chatziantonaki, Ioanna; Tsironis, Christos; Vlahos, Loukas

2012-09-01

We analyze the propagation of electron-cyclotron waves, their absorption and current drive when neoclassical tearing modes (NTMs), in the form of magnetic islands, are present in a tokamak plasma. So far, the analysis of the wave propagation and power deposition in the presence of NTMs has been performed mainly in the frame of an axisymmetric magnetic field, ignoring any effects from the island topology. Our analysis starts from an axisymmetric magnetic equilibrium, which is perturbed such as to exhibit magnetic islands. In this geometry, we compute the wave evolution with a ray-tracing code, focusing on the effect of the island topology on the efficiency of the absorption and current drive. To increase the precision in the calculation of the power deposition, the standard analytical flux-surface labeling for the island region has been adjusted from the usual cylindrical to toroidal geometry. The propagation up to the O-point is found to be little affected by the island topology, whereas the power absorbed and the driven current are significantly enhanced, because the resonant particles are bound to the small volumes in between the flux surfaces of the island. The consequences of these effects on the NTM evolution are investigated in terms of the modified Rutherford equation.

The ABCs of Technology Leasing: Get the Facts on the Pros and Cons of Leasing

ERIC Educational Resources Information Center

Aldridge, Robb

2005-01-01

Ownership means control. What one buys is easier to manage with respect to upgrading or getting rid of equipment that is no longer adequate for the job. Purchasing can put severe demands on cash flow, however, so sometimes the budget drives the decision to lease. Not surprisingly, leasing reverses the advantages and disadvantages of ownership. For…

Servant Leadership--Reversing the Pyramid: Self-Perceptions of Principals and Assistant Principals

ERIC Educational Resources Information Center

Valdes, Eileen Patrice

2009-01-01

Servant leadership is a phrase that was first coined by Robert Greenleaf. He believed that a servant leader is one, who from a leadership position, wants to serve others. That is the primary driving force behind one aspiring to leadership. The purpose of this researcher was to determine if there was a perceivable relationship between the perceived…

How Is Theory of Mind Useful? Perhaps to Enable Social Pretend Play

ERIC Educational Resources Information Center

Dore, Rebecca A.; Smith, Eric D.; Lillard, Angeline S.

2015-01-01

It is often claimed that theory of mind (ToM) is facilitated by pretend play (PP), or by a particular type of PP, social pretend play (SPP). The authors challenge that view, proposing instead that ToM might be useful for driving SPP, rather than the reverse. The authors discuss background theory, review pertinent studies, and explain why the…

Redefining Molecular Amphipathicity in Reversing the "Coffee-Ring Effect": Implications for Single Base Mutation Detection.

PubMed

Huang, Chi; Wang, Jie; Lv, Xiaobo; Liu, Liu; Liang, Ling; Hu, Wei; Luo, Changliang; Wang, Fubing; Yuan, Quan

2018-05-21

The "coffee ring effect" is a natural phenomenon where sessile drops leave ring-shaped structures on solid surfaces upon drying. It drives non-uniform deposition of suspended compounds on substrates, which adversely affects many processes, including surface-assisted biosensing and molecular self-assembly. In this study, we describe how the coffee ring effect can be eliminated by controlling the amphipathicity of the suspended compounds, for example DNA modified with hydrophobic dye. Specifically, nuclease digestion of the hydrophilic DNA end converts the dye-labeled molecule into an amphipathic molecule (one with comparably weighted hydrophobic and hydrophilic ends) and reverses the coffee ring effect and results in uniform disc-shaped feature deposition of the dye. The amphipathic product decreases the surface tension of the sessile drops and induces Marangoni flow, which drives the uniform distribution of the amphipathic dye-labeled product in the drops. As proof-of-concept, this strategy was used in a novel enzymatic amplification method for biosensing to eliminate the coffee ring effect on a nitrocellulose membrane and increase assay reliability and sensitivity. Importantly, the reported strategy for eliminating the coffee ring effect can be extended to other sessile drop systems for potentially improving assay reliability, and sensitivity.

Computer controllable synchronous shifting of an automatic transmission

DOEpatents

Davis, R.I.; Patil, P.B.

1989-08-08

A multiple forward speed automatic transmission produces its lowest forward speed ratio when a hydraulic clutch and hydraulic brake are disengaged and a one-way clutch connects a ring gear to the transmission casing. Second forward speed ratio results when the hydraulic clutch is engaged to connect the ring gear to the planetary carrier of a second gear set. Reverse drive and regenerative operation result when an hydraulic brake fixes the planetary and the direction of power flow is reversed. Various sensors produce signals representing the torque at the output of the transmission or drive wheels, the speed of the power source, and the hydraulic pressure applied to a clutch and brake. A control algorithm produces input data representing a commanded upshift, a commanded downshift, a commanded transmission output torque, and commanded power source speed. A microprocessor processes the inputs and produces a response to them in accordance with the execution of a control algorithm. Output or response signals cause selective engagement and disengagement of the clutch and brake at a rate that satisfies the requirements for a short gear ratio change and smooth torque transfer between the friction elements. 6 figs.

Resolving the role of femtosecond heated electrons in ultrafast spin dynamics.

PubMed

Mendil, J; Nieves, P; Chubykalo-Fesenko, O; Walowski, J; Santos, T; Pisana, S; Münzenberg, M

2014-02-05

Magnetization manipulation is essential for basic research and applications. A fundamental question is, how fast can the magnetization be reversed in nanoscale magnetic storage media. When subject to an ultrafast laser pulse, the speed of the magnetization dynamics depends on the nature of the energy transfer pathway. The order of the spin system can be effectively influenced through spin-flip processes mediated by hot electrons. It has been predicted that as electrons drive spins into the regime close to almost total demagnetization, characterized by a loss of ferromagnetic correlations near criticality, a second slower demagnetization process takes place after the initial fast drop of magnetization. By studying FePt, we unravel the fundamental role of the electronic structure. As the ferromagnet Fe becomes more noble in the FePt compound, the electronic structure is changed and the density of states around the Fermi level is reduced, thereby driving the spin correlations into the limit of critical fluctuations. We demonstrate the impact of the electrons and the ferromagnetic interactions, which allows a general insight into the mechanisms of spin dynamics when the ferromagnetic state is highly excited, and identifies possible recording speed limits in heat-assisted magnetization reversal.

Extended magnetohydrodynamic simulations of field reversed configuration formation and sustainment with rotating magnetic field current drive

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milroy, R. D.; Kim, C. C.; Sovinec, C. R.

Three-dimensional simulations of field reversed configuration (FRC) formation and sustainment with rotating magnetic field (RMF) current drive have been performed with the NIMROD code [C. R. Sovinec et al., J. Comput. Phys. 195, 355 (2004)]. The Hall term is a zeroth order effect with strong coupling between Fourier components, and recent enhancements to the NIMROD preconditioner allow much larger time steps than was previously possible. Boundary conditions to capture the effects of a finite length RMF antenna have been added, and simulations of FRC formation from a uniform background plasma have been performed with parameters relevant to the translation, confinement,more » and sustainment-upgrade experiment at the University of Washington [H. Y. Guo, A. L. Hoffman, and R. D. Milroy, Phys. Plasmas 14, 112502 (2007)]. The effects of both even-parity and odd-parity antennas have been investigated, and there is no evidence of a disruptive instability for either antenna type. It has been found that RMF effects extend considerably beyond the ends of the antenna, and that a large n=0 B{sub t}heta can develop in the open-field line region, producing a back torque opposing the RMF.« less

Suomi-NPP Mission On-Orbit Experience with Toroid Ball Bearing Retainers Under Unidirectional and Reversing Motion

NASA Technical Reports Server (NTRS)

Bruegman, Otto; Thakore, Kamal; Loewenthal, Stu; Cymerman, John

2016-01-01

The Advanced Technology Microwave Sounder (ATMS) instrument scan system on the Suomi National Polar-orbiting Partnership (SNPP) spacecraft has experienced several randomly occurring increased torque 'events' since its on-orbit activation in November 2011. Based on a review of on-orbit telemetry data and data gathered from scan mechanism bearing life testing on the ground, the conclusion was drawn that some degradation of Teflon toroid ball retainers was occurring in the instrument Scan Drive Mechanism. A life extension program was developed and executed on-orbit with very good results to date. The life extension program consisted of reversing the mechanism for a limited number of consecutive scans every day.

Minimal two-sphere model of the generation of fluid flow at low Reynolds numbers.

PubMed

Leoni, M; Bassetti, B; Kotar, J; Cicuta, P; Cosentino Lagomarsino, M

2010-03-01

Locomotion and generation of flow at low Reynolds number are subject to severe limitations due to the irrelevance of inertia: the "scallop theorem" requires that the system have at least two degrees of freedom, which move in non-reciprocal fashion, i.e. breaking time-reversal symmetry. We show here that a minimal model consisting of just two spheres driven by harmonic potentials is capable of generating flow. In this pump system the two degrees of freedom are the mean and relative positions of the two spheres. We have performed and compared analytical predictions, numerical simulation and experiments, showing that a time-reversible drive is sufficient to induce flow.

Kinetic Monte Carlo simulations of thermally activated magnetization reversal in dual-layer Exchange Coupled Composite recording media

NASA Astrophysics Data System (ADS)

Plumer, M. L.; Almudallal, A. M.; Mercer, J. I.; Whitehead, J. P.; Fal, T. J.

The kinetic Monte Carlo (KMC) method developed for thermally activated magnetic reversal processes in single-layer recording media has been extended to study dual-layer Exchange Coupled Composition (ECC) media used in current and next generations of disc drives. The attempt frequency is derived from the Langer formalism with the saddle point determined using a variant of Bellman Ford algorithm. Complication (such as stagnation) arising from coupled grains having metastable states are addressed. MH-hysteresis loops are calculated over a wide range of anisotropy ratios, sweep rates and inter-layer coupling parameter. Results are compared with standard micromagnetics at fast sweep rates and experimental results at slow sweep rates.

Convergence of temperate and tropical stream fish assemblages

EPA Science Inventory

The hypothesis of convergence takes the deterministic view that community (or assemblage) structure can be predicted from the environment, and that the environment is expected to drive evolution in a predictable direction. Here we present results of a comparative study of freshwa...

Reversible switching between pressure-induced amorphization and thermal-driven recrystallization in VO2(B) nanosheets

PubMed Central

Wang, Yonggang; Zhu, Jinlong; Yang, Wenge; Wen, Ting; Pravica, Michael; Liu, Zhenxian; Hou, Mingqiang; Fei, Yingwei; Kang, Lei; Lin, Zheshuai; Jin, Changqing; Zhao, Yusheng

2016-01-01

Pressure-induced amorphization (PIA) and thermal-driven recrystallization have been observed in many crystalline materials. However, controllable switching between PIA and a metastable phase has not been described yet, due to the challenge to establish feasible switching methods to control the pressure and temperature precisely. Here, we demonstrate a reversible switching between PIA and thermally-driven recrystallization of VO2(B) nanosheets. Comprehensive in situ experiments are performed to establish the precise conditions of the reversible phase transformations, which are normally hindered but occur with stimuli beyond the energy barrier. Spectral evidence and theoretical calculations reveal the pressure–structure relationship and the role of flexible VOx polyhedra in the structural switching process. Anomalous resistivity evolution and the participation of spin in the reversible phase transition are observed for the first time. Our findings have significant implications for the design of phase switching devices and the exploration of hidden amorphous materials. PMID:27426219

Coronal Polarization of Pseudostreamers and the Solar Polar Field Reversal

NASA Technical Reports Server (NTRS)

Rachmeler, L. A.; Guennou, C.; Seaton, D. B.; Gibson, S. E.; Auchere, F.

2016-01-01

The reversal of the solar polar magnetic field is notoriously hard to pin down due to the extreme viewing angle of the pole. In Cycle 24, the southern polar field reversal can be pinpointed with high accuracy due to a large-scale pseudostreamer that formed over the pole and persisted for approximately a year. We tracked the size and shape of this structure with multiple observations and analysis techniques including PROBA2/SWAP EUV images, AIA EUV images, CoMP polarization data, and 3D tomographic reconstructions. We find that the heliospheric field reversed polarity in February 2014, whereas in the photosphere, the last vestiges of the previous polar field polarity remained until March 2015. We present here the evolution of the structure and describe its identification in the Fe XII 1074nm coronal emission line, sensitive to the Hanle effect in the corona.

Reversible switching between pressure-induced amorphization and thermal-driven recrystallization in VO2(B) nanosheets.

PubMed

Wang, Yonggang; Zhu, Jinlong; Yang, Wenge; Wen, Ting; Pravica, Michael; Liu, Zhenxian; Hou, Mingqiang; Fei, Yingwei; Kang, Lei; Lin, Zheshuai; Jin, Changqing; Zhao, Yusheng

2016-07-18

Pressure-induced amorphization (PIA) and thermal-driven recrystallization have been observed in many crystalline materials. However, controllable switching between PIA and a metastable phase has not been described yet, due to the challenge to establish feasible switching methods to control the pressure and temperature precisely. Here, we demonstrate a reversible switching between PIA and thermally-driven recrystallization of VO2(B) nanosheets. Comprehensive in situ experiments are performed to establish the precise conditions of the reversible phase transformations, which are normally hindered but occur with stimuli beyond the energy barrier. Spectral evidence and theoretical calculations reveal the pressure-structure relationship and the role of flexible VOx polyhedra in the structural switching process. Anomalous resistivity evolution and the participation of spin in the reversible phase transition are observed for the first time. Our findings have significant implications for the design of phase switching devices and the exploration of hidden amorphous materials.

Variation in promiscuity and sexual selection drives avian rate of Faster-Z evolution.

PubMed

Wright, Alison E; Harrison, Peter W; Zimmer, Fabian; Montgomery, Stephen H; Pointer, Marie A; Mank, Judith E

2015-03-01

Higher rates of coding sequence evolution have been observed on the Z chromosome relative to the autosomes across a wide range of species. However, despite a considerable body of theory, we lack empirical evidence explaining variation in the strength of the Faster-Z Effect. To assess the magnitude and drivers of Faster-Z Evolution, we assembled six de novo transcriptomes, spanning 90 million years of avian evolution. Our analysis combines expression, sequence and polymorphism data with measures of sperm competition and promiscuity. In doing so, we present the first empirical evidence demonstrating the positive relationship between Faster-Z Effect and measures of promiscuity, and therefore variance in male mating success. Our results from multiple lines of evidence indicate that selection is less effective on the Z chromosome, particularly in promiscuous species, and that Faster-Z Evolution in birds is due primarily to genetic drift. Our results reveal the power of mating system and sexual selection in shaping broad patterns in genome evolution. © 2015 John Wiley & Sons Ltd.

Influence of orographic precipitation on the incision within a mountain-piedmont system

NASA Astrophysics Data System (ADS)

Zavala, Valeria; Carretier, Sébastien; Bonnet, Stephane

2017-04-01

The geomorphological evolution of a mountain-piedmont system depends both on tectonics and climate, as well as on couplings between the mountain and its piedmont. Although the interactions between climate and tectonics are a fundamental point for understanding the landscape evolution, the erosion of a mountain range and the sediment deposition at the mountain front, or piedmont, have been poorly studied as a coupled system. Here we focus on the conditions driving an incision within such a system. Classically, it is thought that incision results from a change in climate or uplift rates. However, it is not clear which are the specific conditions that favor the occurrence of river incision in the piedmont. In particular, studies have shown that the presence of a piedmont can modify the incision patterns, and even drive autogenic incision, without any change in external forcings. This is a crucial issue in order to interpret natural incisions in terms of uplift or climatic modifications. Such a problem is further complicated by the modification of local precipitations and temperatures during uplift, because the progressive effect of climate change may superimpose to uplift. In this work we explore the hypothesis that a mountain-piedmont coupled system may develop incision in its piedmont as a result of enhanced orographic precipitations during surface uplift. We use a landscape evolution model, Cidre, in order to explore the response of a mountain-piemont system in which the mountain is continuously uplifted but in which precipitation rates depend on elevations. Thus precipitation amounts change during the mountain uplift. We test different peaks and amplitudes of the orographic precipitation pattern, maintaining the other conditions constant. Preliminary results show that elevation-dependent precipitations drive temporary but pronounced incisions of the main rivers within the piedmont, contrary to experiments without orographic precipitations.

Origin and evolution of SINEs in eukaryotic genomes

PubMed Central

Kramerov, D A; Vassetzky, N S

2011-01-01

Short interspersed elements (SINEs) are one of the two most prolific mobile genomic elements in most of the higher eukaryotes. Although their biology is still not thoroughly understood, unusual life cycle of these simple elements amplified as genomic parasites makes their evolution unique in many ways. In contrast to most genetic elements including other transposons, SINEs emerged de novo many times in evolution from available molecules (for example, tRNA). The involvement of reverse transcription in their amplification cycle, huge number of genomic copies and modular structure allow variation mechanisms in SINEs uncommon or rare in other genetic elements (module exchange between SINE families, dimerization, and so on.). Overall, SINE evolution includes their emergence, progressive optimization and counteraction to the cell's defense against mobile genetic elements. PMID:21673742

Acceleration of planar foils by the indirect-direct drive scheme

NASA Astrophysics Data System (ADS)

Honrubia, J. J.; Martínez-Val, J. M.; Bocher, J. L.; Faucheux, G.

1996-05-01

We have investigated the hydrodynamic response of plastic and aluminum foils accelerated by a pulse formed by an x-ray prepulse followed by the main laser pulse. This illumination scheme, so-called indirect-direct drive scheme, has been proposed as an alternative to the direct and indirect drive. The advantages of such a scheme are that it can contribute to solve the problem of uniformity of the direct drive and, at the same time, it can be much more efficient and use simpler targets than the indirect-drive. Experiments about this hybrid drive scheme have been performed at Limeil with the PHEBUS facility and the standard experimental set-up and diagnostics. The agreement between experiments and simulations is good for quantities such as the energy of the laser converted into x-rays and the burnthrough time of the converter foil. To simulate the full hydrodynamic evolution of the converter and target foils separated a distance of 1 mm, 2-D effects should be taken into account. The basic goals have been to check the simulation codes developed by the Institute of Nuclear Fusion and to determine the hydrodynamic response of the target foil to the hybrid pulse. These goals have been fulfilled.

Modelling of minority ion cyclotron current drive during the activated phase of ITER

NASA Astrophysics Data System (ADS)

Laxåback, M.; Hellsten, T.

2005-12-01

Neoclassical tearing modes, triggered by the long-period sawteeth expected in tokamaks with large non-thermal α-particle populations, may impose a severe β limit on experiments with large fusion yields and on reactors. Sawtooth destabilization by localized current drive could relax the β limit and improve plasma performance. 3He minority ion cyclotron current drive around the sawtooth inversion radius has been planned for ITER. Several ion species, including beam injected D ions and fusion born α particles, are however also resonant in the plasma and may represent a parasitic absorption of RF power. Modelling of minority ion cyclotron current drive in an ITER-FEAT-like plasma is presented, including the effects of ion trapping, finite ion drift orbit widths, wave-induced radial transport and the coupled evolution of wave fields and resonant ion distributions. The parasitic absorption of RF power by the other resonant species is concluded to be relatively small, but the 3He minority current drive is nevertheless negligible due to the strong collisionality of the 3He ions and the drag current by toroidally counter-rotating background ions and co-rotating electrons. H minority current drive is found to be a significantly more effective alternative.

The frequency dependence of the discharge properties in a capacitively coupled oxygen discharge

NASA Astrophysics Data System (ADS)

Gudmundsson, J. T.; Snorrason, D. I.; Hannesdottir, H.

2018-02-01

We use the one-dimensional object-oriented particle-in-cell Monte Carlo collision code oopd1 to explore the evolution of the charged particle density profiles, electron heating mechanism, the electron energy probability function (EEPF), and the ion energy distribution in a single frequency capacitively coupled oxygen discharge, with driving frequency in the range 12-100 MHz. At a low driving frequency and low pressure (5 and 10 mTorr), a combination of stochastic (α-mode) and drift ambipolar (DA) heating in the bulk plasma (the electronegative core) is observed and the DA-mode dominates the time averaged electron heating. As the driving frequency or pressure are increased, the heating mode transitions into a pure α-mode, where electron heating in the sheath region dominates. At low pressure (5 and 10 mTorr), this transition coincides with a sharp decrease in electronegativity. At low pressure and low driving frequency, the EEPF is concave. As the driving frequency is increased, the number of low energy electrons increases and the relative number of higher energy electrons (>10 eV) increases. At high driving frequency, the EEPF develops a convex shape or becomes bi-Maxwellian.

Sequential Bottlenecks Drive Viral Evolution in Early Acute Hepatitis C Virus Infection

PubMed Central

McElroy, Kerensa; Gaudieri, Silvana; Pham, Son T.; Chopra, Abha; Cameron, Barbara; Maher, Lisa; Dore, Gregory J.; White, Peter A.; Lloyd, Andrew R.

2011-01-01

Hepatitis C is a pandemic human RNA virus, which commonly causes chronic infection and liver disease. The characterization of viral populations that successfully initiate infection, and also those that drive progression to chronicity is instrumental for understanding pathogenesis and vaccine design. A comprehensive and longitudinal analysis of the viral population was conducted in four subjects followed from very early acute infection to resolution of disease outcome. By means of next generation sequencing (NGS) and standard cloning/Sanger sequencing, genetic diversity and viral variants were quantified over the course of the infection at frequencies as low as 0.1%. Phylogenetic analysis of reassembled viral variants revealed acute infection was dominated by two sequential bottleneck events, irrespective of subsequent chronicity or clearance. The first bottleneck was associated with transmission, with one to two viral variants successfully establishing infection. The second occurred approximately 100 days post-infection, and was characterized by a decline in viral diversity. In the two subjects who developed chronic infection, this second bottleneck was followed by the emergence of a new viral population, which evolved from the founder variants via a selective sweep with fixation in a small number of mutated sites. The diversity at sites with non-synonymous mutation was higher in predicted cytotoxic T cell epitopes, suggesting immune-driven evolution. These results provide the first detailed analysis of early within-host evolution of HCV, indicating strong selective forces limit viral evolution in the acute phase of infection. PMID:21912520

Model of driven and decaying magnetic turbulence in a cylinder.

PubMed

Kemel, Koen; Brandenburg, Axel; Ji, Hantao

2011-11-01

Using mean-field theory, we compute the evolution of the magnetic field in a cylinder with outer perfectly conducting boundaries and imposed axial magnetic and electric fields. The thus injected magnetic helicity in the system can be redistributed by magnetic helicity fluxes down the gradient of the local current helicity of the small-scale magnetic field. A weak reversal of the axial magnetic field is found to be a consequence of the magnetic helicity flux in the system. Such fluxes are known to alleviate so-called catastrophic quenching of the α effect in astrophysical applications. A stronger field reversal can be obtained if there is also a significant kinetic α effect. Application to the reversed field pinch in plasma confinement devices is discussed.