Modification of a method-of-characteristics solute-transport model to incorporate decay and equilibrium-controlled sorption or ion exchange

USGS Publications Warehouse

Goode, D.J.; Konikow, Leonard F.

1989-01-01

The U.S. Geological Survey computer model of two-dimensional solute transport and dispersion in ground water (Konikow and Bredehoeft, 1978) has been modified to incorporate the following types of chemical reactions: (1) first-order irreversible rate-reaction, such as radioactive decay; (2) reversible equilibrium-controlled sorption with linear, Freundlich, or Langmuir isotherms; and (3) reversible equilibrium-controlled ion exchange for monovalent or divalent ions. Numerical procedures are developed to incorporate these processes in the general solution scheme that uses method-of- characteristics with particle tracking for advection and finite-difference methods for dispersion. The first type of reaction is accounted for by an exponential decay term applied directly to the particle concentration. The second and third types of reactions are incorporated through a retardation factor, which is a function of concentration for nonlinear cases. The model is evaluated and verified by comparison with analytical solutions for linear sorption and decay, and by comparison with other numerical solutions for nonlinear sorption and ion exchange.

Tracking single particle rotation: Probing dynamics in four dimensions

DOE PAGES

Anthony, Stephen Michael; Yu, Yan

2015-04-29

Direct visualization and tracking of small particles at high spatial and temporal resolution provides a powerful approach to probing complex dynamics and interactions in chemical and biological processes. Analysis of the rotational dynamics of particles adds a new dimension of information that is otherwise impossible to obtain with conventional 3-D particle tracking. In this review, we survey recent advances in single-particle rotational tracking, with highlights on the rotational tracking of optically anisotropic Janus particles. Furthermore, strengths and weaknesses of the various particle tracking methods, and their applications are discussed.

Extracting Lyapunov exponents from the echo dynamics of Bose-Einstein condensates on a lattice

NASA Astrophysics Data System (ADS)

Tarkhov, Andrei E.; Wimberger, Sandro; Fine, Boris V.

2017-08-01

We propose theoretically an experimentally realizable method to demonstrate the Lyapunov instability and to extract the value of the largest Lyapunov exponent for a chaotic many-particle interacting system. The proposal focuses specifically on a lattice of coupled Bose-Einstein condensates in the classical regime describable by the discrete Gross-Pitaevskii equation. We suggest to use imperfect time reversal of the system's dynamics known as the Loschmidt echo, which can be realized experimentally by reversing the sign of the Hamiltonian of the system. The routine involves tracking and then subtracting the noise of virtually any observable quantity before and after the time reversal. We support the theoretical analysis by direct numerical simulations demonstrating that the largest Lyapunov exponent can indeed be extracted from the Loschmidt echo routine. We also discuss possible values of experimental parameters required for implementing this proposal.

Particle tracking in drug and gene delivery research: State-of-the-art applications and methods.

PubMed

Schuster, Benjamin S; Ensign, Laura M; Allan, Daniel B; Suk, Jung Soo; Hanes, Justin

2015-08-30

Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during the last decade. Thanks to advances in hardware and software, this technique is now more accessible than ever, and can be reliably automated to enable rapid processing of large data sets, thereby further enhancing the role that particle tracking will play in drug and gene delivery studies in the future. We begin this review by discussing particle tracking-based advances in characterizing extracellular and cellular barriers to therapeutic nanoparticles and in characterizing nanoparticle size and stability. To facilitate wider adoption of the technique, we then present a user-friendly review of state-of-the-art automated particle tracking algorithms and methods of analysis. We conclude by reviewing technological developments for next-generation particle tracking methods, and we survey future research directions in drug and gene delivery where particle tracking may be useful. Copyright © 2015 Elsevier B.V. All rights reserved.

Multisensor fusion for 3D target tracking using track-before-detect particle filter

NASA Astrophysics Data System (ADS)

Moshtagh, Nima; Romberg, Paul M.; Chan, Moses W.

2015-05-01

This work presents a novel fusion mechanism for estimating the three-dimensional trajectory of a moving target using images collected by multiple imaging sensors. The proposed projective particle filter avoids the explicit target detection prior to fusion. In projective particle filter, particles that represent the posterior density (of target state in a high-dimensional space) are projected onto the lower-dimensional observation space. Measurements are generated directly in the observation space (image plane) and a marginal (sensor) likelihood is computed. The particles states and their weights are updated using the joint likelihood computed from all the sensors. The 3D state estimate of target (system track) is then generated from the states of the particles. This approach is similar to track-before-detect particle filters that are known to perform well in tracking dim and stealthy targets in image collections. Our approach extends the track-before-detect approach to 3D tracking using the projective particle filter. The performance of this measurement-level fusion method is compared with that of a track-level fusion algorithm using the projective particle filter. In the track-level fusion algorithm, the 2D sensor tracks are generated separately and transmitted to a fusion center, where they are treated as measurements to the state estimator. The 2D sensor tracks are then fused to reconstruct the system track. A realistic synthetic scenario with a boosting target was generated, and used to study the performance of the fusion mechanisms.

Charged particle tracking at Titan, and further applications

NASA Astrophysics Data System (ADS)

Bebesi, Zsofia; Erdos, Geza; Szego, Karoly

2016-04-01

We use the CAPS ion data of Cassini to investigate the dynamics and origin of Titan's atmospheric ions. We developed a 4th order Runge-Kutta method to calculate particle trajectories in a time reversed scenario. The test particle magnetic field environment imitates the curved magnetic environment in the vicinity of Titan. The minimum variance directions along the S/C trajectory have been calculated for all available Titan flybys, and we assumed a homogeneous field that is perpendicular to the minimum variance direction. Using this method the magnetic field lines have been calculated along the flyby orbits so we could select those observational intervals when Cassini and the upper atmosphere of Titan were magnetically connected. We have also taken the Kronian magnetodisc into consideration, and used different upstream magnetic field approximations depending on whether Titan was located inside of the magnetodisc current sheet, or in the lobe regions. We also discuss the code's applicability to comets.

Flow path oscillations in transient ground-water simulations of large peatland systems

USGS Publications Warehouse

Reeve, A.S.; Evensen, R.; Glaser, P.H.; Siegel, D.I.; Rosenberry, D.

2006-01-01

Transient numerical simulations of the Glacial Lake Agassiz Peatland near the Red Lakes in Northern Minnesota were constructed to evaluate observed reversals in vertical ground-water flow. Seasonal weather changes were introduced to a ground-water flow model by varying evapotranspiration and recharge over time. Vertical hydraulic reversals, driven by changes in recharge and evapotranspiration were produced in the simulated peat layer. These simulations indicate that the high specific storage associated with the peat is an important control on hydraulic reversals. Seasonally driven vertical flow is on the order of centimeters in the deep peat, suggesting that seasonal vertical advective fluxes are not significant and that ground-water flow into the deep peat likely occurs on decadal or longer time scales. Particles tracked within the ground-water flow model oscillate over time, suggesting that seasonal flow reversals will enhance vertical mixing in the peat column. The amplitude of flow path oscillations increased with increasing peat storativity, with amplitudes of about 5 cm occurring when peat specific storativity was set to about 0.05 m-1. ?? 2005 Elsevier B.V. All rights reserved.

A Radiation Chemistry Code Based on the Green's Function of the Diffusion Equation

NASA Technical Reports Server (NTRS)

Plante, Ianik; Wu, Honglu

2014-01-01

Stochastic radiation track structure codes are of great interest for space radiation studies and hadron therapy in medicine. These codes are used for a many purposes, notably for microdosimetry and DNA damage studies. In the last two decades, they were also used with the Independent Reaction Times (IRT) method in the simulation of chemical reactions, to calculate the yield of various radiolytic species produced during the radiolysis of water and in chemical dosimeters. Recently, we have developed a Green's function based code to simulate reversible chemical reactions with an intermediate state, which yielded results in excellent agreement with those obtained by using the IRT method. This code was also used to simulate and the interaction of particles with membrane receptors. We are in the process of including this program for use with the Monte-Carlo track structure code Relativistic Ion Tracks (RITRACKS). This recent addition should greatly expand the capabilities of RITRACKS, notably to simulate DNA damage by both the direct and indirect effect.

Brownian dynamics of confined rigid bodies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Delong, Steven; Balboa Usabiaga, Florencio; Donev, Aleksandar, E-mail: donev@courant.nyu.edu

2015-10-14

We introduce numerical methods for simulating the diffusive motion of rigid bodies of arbitrary shape immersed in a viscous fluid. We parameterize the orientation of the bodies using normalized quaternions, which are numerically robust, space efficient, and easy to accumulate. We construct a system of overdamped Langevin equations in the quaternion representation that accounts for hydrodynamic effects, preserves the unit-norm constraint on the quaternion, and is time reversible with respect to the Gibbs-Boltzmann distribution at equilibrium. We introduce two schemes for temporal integration of the overdamped Langevin equations of motion, one based on the Fixman midpoint method and the othermore » based on a random finite difference approach, both of which ensure that the correct stochastic drift term is captured in a computationally efficient way. We study several examples of rigid colloidal particles diffusing near a no-slip boundary and demonstrate the importance of the choice of tracking point on the measured translational mean square displacement (MSD). We examine the average short-time as well as the long-time quasi-two-dimensional diffusion coefficient of a rigid particle sedimented near a bottom wall due to gravity. For several particle shapes, we find a choice of tracking point that makes the MSD essentially linear with time, allowing us to estimate the long-time diffusion coefficient efficiently using a Monte Carlo method. However, in general, such a special choice of tracking point does not exist, and numerical techniques for simulating long trajectories, such as the ones we introduce here, are necessary to study diffusion on long time scales.« less

Improving z-tracking accuracy in the two-photon single-particle tracking microscope.

PubMed

Liu, C; Liu, Y-L; Perillo, E P; Jiang, N; Dunn, A K; Yeh, H-C

2015-10-12

Here, we present a method that can improve the z-tracking accuracy of the recently invented TSUNAMI (Tracking of Single particles Using Nonlinear And Multiplexed Illumination) microscope. This method utilizes a maximum likelihood estimator (MLE) to determine the particle's 3D position that maximizes the likelihood of the observed time-correlated photon count distribution. Our Monte Carlo simulations show that the MLE-based tracking scheme can improve the z-tracking accuracy of TSUNAMI microscope by 1.7 fold. In addition, MLE is also found to reduce the temporal correlation of the z-tracking error. Taking advantage of the smaller and less temporally correlated z-tracking error, we have precisely recovered the hybridization-melting kinetics of a DNA model system from thousands of short single-particle trajectories in silico . Our method can be generally applied to other 3D single-particle tracking techniques.

Improving z-tracking accuracy in the two-photon single-particle tracking microscope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, C.; Liu, Y.-L.; Perillo, E. P.

Here, we present a method that can improve the z-tracking accuracy of the recently invented TSUNAMI (Tracking of Single particles Using Nonlinear And Multiplexed Illumination) microscope. This method utilizes a maximum likelihood estimator (MLE) to determine the particle's 3D position that maximizes the likelihood of the observed time-correlated photon count distribution. Our Monte Carlo simulations show that the MLE-based tracking scheme can improve the z-tracking accuracy of TSUNAMI microscope by 1.7 fold. In addition, MLE is also found to reduce the temporal correlation of the z-tracking error. Taking advantage of the smaller and less temporally correlated z-tracking error, we havemore » precisely recovered the hybridization-melting kinetics of a DNA model system from thousands of short single-particle trajectories in silico. Our method can be generally applied to other 3D single-particle tracking techniques.« less

Forward-backward multiplicity correlations of target fragments in nucleus-emulsion collisions at a few hundred MeV/u

NASA Astrophysics Data System (ADS)

Zhang, Dong-Hai; Chen, Yan-Ling; Wang, Guo-Rong; Li, Wang-Dong; Wang, Qing; Yao, Ji-Jie; Zhou, Jian-Guo; Li, Rong; Li, Jun-Sheng; Li, Hui-Ling

2015-01-01

The forward-backward multiplicity and correlations of a target evaporated fragment (black track particle) and target recoiled proton (grey track particle) emitted from 150 A MeV 4He, 290 A MeV 12C, 400 A MeV 12C, 400 A MeV 20Ne and 500 A MeV 56Fe induced different types of nuclear emulsion target interactions are investigated. It is found that the forward and backward averaged multiplicity of a grey, black and heavily ionized track particle increases with the increase of the target size. The averaged multiplicity of a forward black track particle, backward black track particle, and backward grey track particle do not depend on the projectile size and energy, but the averaged multiplicity of a forward grey track particle increases with an increase of projectile size and energy. The backward grey track particle multiplicity distribution follows an exponential decay law and the decay constant decreases with an increase of target size. The backward-forward multiplicity correlations follow linear law which is independent of the projectile size and energy, and the saturation effect is observed in some heavy target data sets.

Real-time particle tracking for studying intracellular trafficking of pharmaceutical nanocarriers.

PubMed

Huang, Feiran; Watson, Erin; Dempsey, Christopher; Suh, Junghae

2013-01-01

Real-time particle tracking is a technique that combines fluorescence microscopy with object tracking and computing and can be used to extract quantitative transport parameters for small particles inside cells. Since the success of a nanocarrier can often be determined by how effectively it delivers cargo to the target organelle, understanding the complex intracellular transport of pharmaceutical nanocarriers is critical. Real-time particle tracking provides insight into the dynamics of the intracellular behavior of nanoparticles, which may lead to significant improvements in the design and development of novel delivery systems. Unfortunately, this technique is not often fully understood, limiting its implementation by researchers in the field of nanomedicine. In this chapter, one of the most complicated aspects of particle tracking, the mean square displacement (MSD) calculation, is explained in a simple manner designed for the novice particle tracker. Pseudo code for performing the MSD calculation in MATLAB is also provided. This chapter contains clear and comprehensive instructions for a series of basic procedures in the technique of particle tracking. Instructions for performing confocal microscopy of nanoparticle samples are provided, and two methods of determining particle trajectories that do not require commercial particle-tracking software are provided. Trajectory analysis and determination of the tracking resolution are also explained. By providing comprehensive instructions needed to perform particle-tracking experiments, this chapter will enable researchers to gain new insight into the intracellular dynamics of nanocarriers, potentially leading to the development of more effective and intelligent therapeutic delivery vectors.

Force and Directional Force Modulation Effects on Accuracy and Variability in Low-Level Pinch Force Tracking.

PubMed

Park, Sangsoo; Spirduso, Waneen; Eakin, Tim; Abraham, Lawrence

2018-01-01

The authors investigated how varying the required low-level forces and the direction of force change affect accuracy and variability of force production in a cyclic isometric pinch force tracking task. Eighteen healthy right-handed adult volunteers performed the tracking task over 3 different force ranges. Root mean square error and coefficient of variation were higher at lower force levels and during minimum reversals compared with maximum reversals. Overall, the thumb showed greater root mean square error and coefficient of variation scores than did the index finger during maximum reversals, but not during minimum reversals. The observed impaired performance during minimum reversals might originate from history-dependent mechanisms of force production and highly coupled 2-digit performance.

A Globally Optimal Particle Tracking Technique for Stereo Imaging Velocimetry Experiments

NASA Technical Reports Server (NTRS)

McDowell, Mark

2008-01-01

An important phase of any Stereo Imaging Velocimetry experiment is particle tracking. Particle tracking seeks to identify and characterize the motion of individual particles entrained in a fluid or air experiment. We analyze a cylindrical chamber filled with water and seeded with density-matched particles. In every four-frame sequence, we identify a particle track by assigning a unique track label for each camera image. The conventional approach to particle tracking is to use an exhaustive tree-search method utilizing greedy algorithms to reduce search times. However, these types of algorithms are not optimal due to a cascade effect of incorrect decisions upon adjacent tracks. We examine the use of a guided evolutionary neural net with simulated annealing to arrive at a globally optimal assignment of tracks. The net is guided both by the minimization of the search space through the use of prior limiting assumptions about valid tracks and by a strategy which seeks to avoid high-energy intermediate states which can trap the net in a local minimum. A stochastic search algorithm is used in place of back-propagation of error to further reduce the chance of being trapped in an energy well. Global optimization is achieved by minimizing an objective function, which includes both track smoothness and particle-image utilization parameters. In this paper we describe our model and present our experimental results. We compare our results with a nonoptimizing, predictive tracker and obtain an average increase in valid track yield of 27 percent

Non-iterative double-frame 2D/3D particle tracking velocimetry

NASA Astrophysics Data System (ADS)

Fuchs, Thomas; Hain, Rainer; Kähler, Christian J.

2017-09-01

In recent years, the detection of individual particle images and their tracking over time to determine the local flow velocity has become quite popular for planar and volumetric measurements. Particle tracking velocimetry has strong advantages compared to the statistical analysis of an ensemble of particle images by means of cross-correlation approaches, such as particle image velocimetry. Tracking individual particles does not suffer from spatial averaging and therefore bias errors can be avoided. Furthermore, the spatial resolution can be increased up to the sub-pixel level for mean fields. A maximization of the spatial resolution for instantaneous measurements requires high seeding concentrations. However, it is still challenging to track particles at high seeding concentrations, if no time series is available. Tracking methods used under these conditions are typically very complex iterative algorithms, which require expert knowledge due to the large number of adjustable parameters. To overcome these drawbacks, a new non-iterative tracking approach is introduced in this letter, which automatically analyzes the motion of the neighboring particles without requiring to specify any parameters, except for the displacement limits. This makes the algorithm very user friendly and also offers unexperienced users to use and implement particle tracking. In addition, the algorithm enables measurements of high speed flows using standard double-pulse equipment and estimates the flow velocity reliably even at large particle image densities.

Three-Dimensional Visualization of Particle Tracks.

ERIC Educational Resources Information Center

Julian, Glenn M.

1993-01-01

Suggests ways to bring home to the introductory physics student some of the excitement of recent discoveries in particle physics. Describes particle detectors and encourages the use of the Standard Model along with real images of particle tracks to determine three-dimensional views of tracks. (MVL)

Apparatus and method for tracking a molecule or particle in three dimensions

DOEpatents

Werner, James H [Los Alamos, NM; Goodwin, Peter M [Los Alamos, NM; Lessard, Guillaume [Santa Fe, NM

2009-03-03

An apparatus and method were used to track the movement of fluorescent particles in three dimensions. Control software was used with the apparatus to implement a tracking algorithm for tracking the motion of the individual particles in glycerol/water mixtures. Monte Carlo simulations suggest that the tracking algorithms in combination with the apparatus may be used for tracking the motion of single fluorescent or fluorescently labeled biomolecules in three dimensions.

Microscopic Characterization of Individual Submicron Bubbles during the Layer-by-Layer Deposition: Towards Creating Smart Agents

NASA Astrophysics Data System (ADS)

Kato, Riku; Frusawa, Hiroshi

2015-07-01

We investigated the individual properties of various polyion-coated bubbles with a mean diameter ranging from 300 to 500 nm. Dark field microscopy allows one to track the individual particles of the submicron bubbles (SBs) encapsulated by the layer-by-layer (LbL) deposition of cationic and anionic polyelectrolytes (PEs). Our focus is on the two-step charge reversals of PE-SB complexes: the first is a reversal from negatively charged bare SBs with no PEs added to positive SBs encapsulated by polycations (monolayer deposition), and the second is overcharging into negatively charged PE-SB complexes due to the subsequent addition of polyanions (double-layer deposition). The details of these phenomena have been clarified through the analysis of a number of trajectories of various PE-SB complexes that experience either Brownian motion or electrophoresis. The contrasted results obtained from the analysis were as follows: an amount in excess of the stoichiometric ratio of the cationic polymers was required for the first charge-reversal, whereas the stoichiometric addition of the polyanions lead to the electrical neutralization of the PE-SB complex particles. The recovery of the stoichiometry in the double-layer deposition paves the way for fabricating multi-layered SBs encapsulated solely with anionic and cationic PEs, which provides a simple protocol to create smart agents for either drug delivery or ultrasound contrast imaging.

Microscopic Characterization of Individual Submicron Bubbles during the Layer-by-Layer Deposition: Towards Creating Smart Agents.

PubMed

Kato, Riku; Frusawa, Hiroshi

2015-07-08

We investigated the individual properties of various polyion-coated bubbles with a mean diameter ranging from 300 to 500 nm. Dark field microscopy allows one to track the individual particles of the submicron bubbles (SBs) encapsulated by the layer-by-layer (LbL) deposition of cationic and anionic polyelectrolytes (PEs). Our focus is on the two-step charge reversals of PE-SB complexes: the first is a reversal from negatively charged bare SBs with no PEs added to positive SBs encapsulated by polycations (monolayer deposition), and the second is overcharging into negatively charged PE-SB complexes due to the subsequent addition of polyanions (double-layer deposition). The details of these phenomena have been clarified through the analysis of a number of trajectories of various PE-SB complexes that experience either Brownian motion or electrophoresis. The contrasted results obtained from the analysis were as follows: an amount in excess of the stoichiometric ratio of the cationic polymers was required for the first charge-reversal, whereas the stoichiometric addition of the polyanions lead to the electrical neutralization of the PE-SB complex particles. The recovery of the stoichiometry in the double-layer deposition paves the way for fabricating multi-layered SBs encapsulated solely with anionic and cationic PEs, which provides a simple protocol to create smart agents for either drug delivery or ultrasound contrast imaging.

Adaptation of reference volumes for correlation-based digital holographic particle tracking

NASA Astrophysics Data System (ADS)

Hesseling, Christina; Peinke, Joachim; Gülker, Gerd

2018-04-01

Numerically reconstructed reference volumes tailored to particle images are used for particle position detection by means of three-dimensional correlation. After a first tracking of these positions, the experimentally recorded particle images are retrieved as a posteriori knowledge about the particle images in the system. This knowledge is used for a further refinement of the detected positions. A transparent description of the individual algorithm steps including the results retrieved with experimental data complete the paper. The work employs extraordinarily small particles, smaller than the pixel pitch of the camera sensor. It is the first approach known to the authors that combines numerical knowledge about particle images and particle images retrieved from the experimental system to an iterative particle tracking approach for digital holographic particle tracking velocimetry.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myhra, S., E-mail: sverre.myhra@materials.ox.ac.uk; Chakalova, R.; Falzone, N.

A method for detection and characterization of single MeV α-particle and recoil tracks in PMMA photoresist by atomic force microscopy (AFM) analysis has been demonstrated. The energy deposition along the track is shown to lead to a latent pattern in the resist due to contrast reversal. It has been shown that the pattern, consisting of conical spikes, can be developed by conventional processing as a result of the dissolution rate of poly(methyl methacrylate) (PMMA) being greater than that for the modified material in the cylindrical volume of the track core. The spikes can be imaged and counted by routine AFMmore » analysis. Investigations by angular-resolved near-grazing incidence reveal additional tracks that correspond to recoil tracks. The observations have been correlated with modelling, and shown to be in qualitative agreement with prevailing descriptions of collision cascades. The results may be relevant to technologies that are based on detection and characterization of single energetic ions. In particular, the direct visualization of the collision cascade may allow more accurate estimates of the actual interaction volume, which in turn will permit more precise assessment of dose distribution of α-emitting radionuclides used for targeted radiotherapy. The results could also be relevant to other diagnostic or process technologies based on interaction of energetic ions with matter.« less

Symplectic orbit and spin tracking code for all-electric storage rings

NASA Astrophysics Data System (ADS)

Talman, Richard M.; Talman, John D.

2015-07-01

Proposed methods for measuring the electric dipole moment (EDM) of the proton use an intense, polarized proton beam stored in an all-electric storage ring "trap." At the "magic" kinetic energy of 232.792 MeV, proton spins are "frozen," for example always parallel to the instantaneous particle momentum. Energy deviation from the magic value causes in-plane precession of the spin relative to the momentum. Any nonzero EDM value will cause out-of-plane precession—measuring this precession is the basis for the EDM determination. A proposed implementation of this measurement shows that a proton EDM value of 10-29e -cm or greater will produce a statistically significant, measurable precession after multiply repeated runs, assuming small beam depolarization during 1000 s runs, with high enough precision to test models of the early universe developed to account for the present day particle/antiparticle population imbalance. This paper describes an accelerator simulation code, eteapot, a new component of the Unified Accelerator Libraries (ual), to be used for long term tracking of particle orbits and spins in electric bend accelerators, in order to simulate EDM storage ring experiments. Though qualitatively much like magnetic rings, the nonconstant particle velocity in electric rings gives them significantly different properties, especially in weak focusing rings. Like the earlier code teapot (for magnetic ring simulation) this code performs exact tracking in an idealized (approximate) lattice rather than the more conventional approach, which is approximate tracking in a more nearly exact lattice. The Bargmann-Michel-Telegdi (BMT) equation describing the evolution of spin vectors through idealized bend elements is also solved exactly—original to this paper. Furthermore the idealization permits the code to be exactly symplectic (with no artificial "symplectification"). Any residual spurious damping or antidamping is sufficiently small to permit reliable tracking for the long times, such as the 1000 s assumed in estimating the achievable EDM precision. This paper documents in detail the theoretical formulation implemented in eteapot. An accompanying paper describes the practical application of the eteapot code in the Universal Accelerator Libraries (ual) environment to "resurrect," or reverse engineer, the "AGS-analog" all-electric ring built at Brookhaven National Laboratory in 1954. Of the (very few) all-electric rings ever commissioned, the AGS-analog ring is the only relativistic one and is the closest to what is needed for measuring proton (or, even more so, electron) EDM's. The companion paper also describes preliminary lattice studies for the planned proton EDM storage rings as well as testing the code for long time orbit and spin tracking.

Numerical modelling of organic waste dispersion from fjord located fish farms

NASA Astrophysics Data System (ADS)

Ali, Alfatih; Thiem, Øyvind; Berntsen, Jarle

2011-07-01

In this study, a three-dimensional particle tracking model coupled to a terrain following ocean model is used to investigate the dispersion and the deposition of fish farm particulate matter (uneaten food and fish faeces) on the seabed due to tidal currents. The particle tracking model uses the computed local flow field for advection of the particles and random movement to simulate the turbulent diffusion. Each particle is given a settling velocity which may be drawn from a probability distribution according to settling velocity measurements of faecal and feed pellets. The results show that the maximum concentration of organic waste for fast sinking particles is found under the fish cage and continue monotonically decreasing away from the cage area. The maximum can split into two maximum peaks located at both sides of the centre of the fish cage area in the current direction. This process depends on the sinking time (time needed for a particle to settle at the bottom), the tidal velocity and the fish cage size. If the sinking time is close to a multiple of the tidal period, the maximum concentration point will be under the fish cage irrespective of the tide strength. This is due to the nature of the tidal current first propagating the particles away and then bringing them back when the tide reverses. Increasing the cage size increases the likelihood for a maximum waste accumulation beneath the fish farm, and larger farms usually means larger biomasses which can make the local pollution even more severe. The model is validated by using an analytical model which uses an exact harmonic representation of the tidal current, and the results show an excellent agreement. This study shows that the coupled ocean and particle model can be used in more realistic applications to help estimating the local environmental impact due to fish farms.

Particle track identification: application of a new technique to apollo helmets.

PubMed

Fleischer, R L; Hart, H R; Giard, W R

1970-12-11

The Apollo helmets are being used to record the dose of heavy particles to which astronauts are exposed on space missions. An improved method for examining and identifying the etched tracks of heavy charged particles consists of replicating tracks and measuring the etching rate as a function of position along the track. Tracks have been observed in Apollo helmets that correspond to ionized atoms heavier than iron.

Development of groundwater vulnerability zones in a data-scarce eogenetic karst area using Head-Guided Zonation and particle-tracking simulation methods.

PubMed

Klaas, Dua K S Y; Imteaz, Monzur Alam; Arulrajah, Arul

2017-10-01

Delineation of groundwater vulnerability zones based on a valid groundwater model is crucial towards an accurate design of management strategies. However, limited data often restrain the development of a robust groundwater model. This study presents a methodology to develop groundwater vulnerability zones in a data-scarce area. The Head-Guided Zonation (HGZ) method was applied on the recharge area of Oemau Spring in Rote Island, Indonesia, which is under potential risk of contamination from rapid land use changes. In this method the model domain is divided into zones of piecewise constant into which the values of subsurface properties are assigned in the parameterisation step. Using reverse particle-tracking simulation on the calibrated and validated groundwater model, the simulation results (travel time and pathline trajectory) were combined with the potential groundwater contamination risk from human activities (land use type and current practice) to develop three vulnerability zones. The corresponding preventive management strategies were proposed to protect the spring from contamination and to ensure provision of safe and good quality water from the spring. Copyright © 2017 Elsevier Ltd. All rights reserved.

Dual-color multiple-particle tracking at 50-nm localization and over 100-µm range in 3D with temporal focusing two-photon microscopy

PubMed Central

Ding, Yu; Li, Chunqiang

2016-01-01

Nanoscale particle tracking in three dimensions is crucial to directly observe dynamics of molecules and nanoparticles in living cells. Here we present a three-dimensional particle tracking method based on temporally focused two-photon excitation. Multiple particles are imaged at 30 frames/s in volume up to 180 × 180 × 100 µm3. The spatial localization precision can reach 50 nm. We demonstrate its capability of tracking fast swimming microbes at speed of ~200 µm/s. Two-photon dual-color tracking is achieved by simultaneously exciting two kinds of fluorescent beads at 800 nm to demonstrate its potential in molecular interaction studies. Our method provides a simple wide-field fluorescence imaging approach for deep multiple-particle tracking. PMID:27867724

Method and system for detecting polygon boundaries of structures in images as particle tracks through fields of corners and pixel gradients

DOEpatents

Paglieroni, David W [Pleasanton, CA; Manay, Siddharth [Livermore, CA

2011-12-20

A stochastic method and system for detecting polygon structures in images, by detecting a set of best matching corners of predetermined acuteness .alpha. of a polygon model from a set of similarity scores based on GDM features of corners, and tracking polygon boundaries as particle tracks using a sequential Monte Carlo approach. The tracking involves initializing polygon boundary tracking by selecting pairs of corners from the set of best matching corners to define a first side of a corresponding polygon boundary; tracking all intermediate sides of the polygon boundaries using a particle filter, and terminating polygon boundary tracking by determining the last side of the tracked polygon boundaries to close the polygon boundaries. The particle tracks are then blended to determine polygon matches, which may be made available, such as to a user, for ranking and inspection.

Positron emission particle tracking and its application to granular media

NASA Astrophysics Data System (ADS)

Parker, D. J.

2017-05-01

Positron emission particle tracking (PEPT) is a technique for tracking a single radioactively labelled particle. Accurate 3D tracking is possible even when the particle is moving at high speed inside a dense opaque system. In many cases, tracking a single particle within a granular system provides sufficient information to determine the time-averaged behaviour of the entire granular system. After a general introduction, this paper describes the detector systems (PET scanners and positron cameras) used to record PEPT data, the techniques used to label particles, and the algorithms used to process the data. This paper concentrates on the use of PEPT for studying granular systems: the focus is mainly on work at Birmingham, but reference is also made to work from other centres, and options for wider diversification are suggested.

Determination of time zero from a charged particle detector

DOEpatents

Green, Jesse Andrew [Los Alamos, NM

2011-03-15

A method, system and computer program is used to determine a linear track having a good fit to a most likely or expected path of charged particle passing through a charged particle detector having a plurality of drift cells. Hit signals from the charged particle detector are associated with a particular charged particle track. An initial estimate of time zero is made from these hit signals and linear tracks are then fit to drift radii for each particular time-zero estimate. The linear track having the best fit is then searched and selected and errors in fit and tracking parameters computed. The use of large and expensive fast detectors needed to time zero in the charged particle detectors can be avoided by adopting this method and system.

On charged particle tracks in cellulose nitrate and Lexan

NASA Technical Reports Server (NTRS)

Benton, E. V.; Henke, R. P.

1972-01-01

Investigations were performed aimed at developing plastic nuclear track detectors into quantitative tools for recording and measuring multicharged, heavy particles. Accurate track etch rate measurements as a function of LET were performed for cellulose nitrate and Lexan plastic detectors. This was done using a variety of incident charged particle types and energies. The effect of aging of latent tracks in Lexan in different gaseous atmospheres was investigated. Range distributions of high energy N-14 particle bevatron beams in nuclear emulsion were measured. Investigation of charge resolution and Bragg peak measurements were carried out using plastic nuclear track detectors.

Three-dimensional spatiotemporal tracking of fluorine-18 radiolabeled yeast cells via positron emission particle tracking

DOE PAGES

Langford, Seth T.; Wiggins, Cody S.; Santos, Roque; ...

2017-07-06

A method for Positron Emission Particle Tracking (PEPT) based on optical feature point identification techniques is demonstrated for use in low activity tracking experiments. Furthermore, a population of yeast cells of approximately 125,000 members is activated to roughly 55 Bq/cell by 18F uptake. An in vitro particle tracking experiment is performed with nearly 20 of these cells after decay to 32 Bq/cell. These cells are successfully identified and tracked simultaneously in this experiment. Our work extends the applicability of PEPT as a cell tracking method by allowing a number of cells to be tracked together, and demonstrating tracking for verymore » low activity tracers.« less

Three-dimensional spatiotemporal tracking of fluorine-18 radiolabeled yeast cells via positron emission particle tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Langford, Seth T.; Wiggins, Cody S.; Santos, Roque

A method for Positron Emission Particle Tracking (PEPT) based on optical feature point identification techniques is demonstrated for use in low activity tracking experiments. Furthermore, a population of yeast cells of approximately 125,000 members is activated to roughly 55 Bq/cell by 18F uptake. An in vitro particle tracking experiment is performed with nearly 20 of these cells after decay to 32 Bq/cell. These cells are successfully identified and tracked simultaneously in this experiment. Our work extends the applicability of PEPT as a cell tracking method by allowing a number of cells to be tracked together, and demonstrating tracking for verymore » low activity tracers.« less

Influence of the Minho River plume on the Rias Baixas (NW of the Iberian Peninsula)

NASA Astrophysics Data System (ADS)

Sousa, M. C.; Vaz, N.; Alvarez, I.; Gomez-Gesteira, M.; Dias, J. M.

2014-11-01

The buoyancy generated by the Minho estuarine plume can flood the Rias Baixas for long periods, reversing the normal salinity gradients. Thus, the main purpose of this work was to study the propagation of Minho estuarine plume to the Rias Baixas, establishing the wind and river discharge conditions in which this plume affects the circulation and hydrography features of these coastal systems as well as the plume characteristics under the most probable forcing conditions, through the application of the numerical model MOHID. For this purpose, several scenarios with different river discharges and wind were simulated. The numerical results revealed that the Minho estuarine plume responds rapidly to wind variations and is influenced by coastline geometry. Under Minho River discharges higher than 700 m3 s- 1 and weak northward winds (3 m s- 1) the circulation patterns of the Rias de Vigo and Pontevedra are reversed. On the other hand, moderate northward winds (6 m s- 1) combined with Minho River discharges higher than 200 m3 s- 1, 300 m3 s- 1 and 700 m3 s- 1 reverse the circulation pattern of the Rias de Vigo, Pontevedra and Arousa, respectively. Under the same conditions, the water exchange between Rias Baixas was analyzed using a particle-tracking model following the trajectories of particles released close to the Minho River mouth. Over 5 days, under Minho River discharges higher than 2100 m3 s- 1 combined with northward winds of 6 m s- 1, an intense water exchange between Rias was observed. However, only 20% of the particles found in Ria de Pontevedra come directly from the Minho River.

Tracking Algorithm of Multiple Pedestrians Based on Particle Filters in Video Sequences

PubMed Central

Liu, Yun; Wang, Chuanxu; Zhang, Shujun; Cui, Xuehong

2016-01-01

Pedestrian tracking is a critical problem in the field of computer vision. Particle filters have been proven to be very useful in pedestrian tracking for nonlinear and non-Gaussian estimation problems. However, pedestrian tracking in complex environment is still facing many problems due to changes of pedestrian postures and scale, moving background, mutual occlusion, and presence of pedestrian. To surmount these difficulties, this paper presents tracking algorithm of multiple pedestrians based on particle filters in video sequences. The algorithm acquires confidence value of the object and the background through extracting a priori knowledge thus to achieve multipedestrian detection; it adopts color and texture features into particle filter to get better observation results and then automatically adjusts weight value of each feature according to current tracking environment. During the process of tracking, the algorithm processes severe occlusion condition to prevent drift and loss phenomena caused by object occlusion and associates detection results with particle state to propose discriminated method for object disappearance and emergence thus to achieve robust tracking of multiple pedestrians. Experimental verification and analysis in video sequences demonstrate that proposed algorithm improves the tracking performance and has better tracking results. PMID:27847514

Environmental factors and flow paths related to Escherichia coli concentrations at two beaches on Lake St. Clair, Michigan, 2002–2005

USGS Publications Warehouse

Holtschlag, David J.; Shively, Dawn; Whitman, Richard L.; Haack, Sheridan K.; Fogarty, Lisa R.

2008-01-01

Regression analyses and hydrodynamic modeling were used to identify environmental factors and flow paths associated with Escherichia coli (E. coli) concentrations at Memorial and Metropolitan Beaches on Lake St. Clair in Macomb County, Mich. Lake St. Clair is part of the binational waterway between the United States and Canada that connects Lake Huron with Lake Erie in the Great Lakes Basin. Linear regression, regression-tree, and logistic regression models were developed from E. coli concentration and ancillary environmental data. Linear regression models on log10 E. coli concentrations indicated that rainfall prior to sampling, water temperature, and turbidity were positively associated with bacteria concentrations at both beaches. Flow from Clinton River, changes in water levels, wind conditions, and log10 E. coli concentrations 2 days before or after the target bacteria concentrations were statistically significant at one or both beaches. In addition, various interaction terms were significant at Memorial Beach. Linear regression models for both beaches explained only about 30 percent of the variability in log10 E. coli concentrations. Regression-tree models were developed from data from both Memorial and Metropolitan Beaches but were found to have limited predictive capability in this study. The results indicate that too few observations were available to develop reliable regression-tree models. Linear logistic models were developed to estimate the probability of E. coli concentrations exceeding 300 most probable number (MPN) per 100 milliliters (mL). Rainfall amounts before bacteria sampling were positively associated with exceedance probabilities at both beaches. Flow of Clinton River, turbidity, and log10 E. coli concentrations measured before or after the target E. coli measurements were related to exceedances at one or both beaches. The linear logistic models were effective in estimating bacteria exceedances at both beaches. A receiver operating characteristic (ROC) analysis was used to determine cut points for maximizing the true positive rate prediction while minimizing the false positive rate. A two-dimensional hydrodynamic model was developed to simulate horizontal current patterns on Lake St. Clair in response to wind, flow, and water-level conditions at model boundaries. Simulated velocity fields were used to track hypothetical massless particles backward in time from the beaches along flow paths toward source areas. Reverse particle tracking for idealized steady-state conditions shows changes in expected flow paths and traveltimes with wind speeds and directions from 24 sectors. The results indicate that three to four sets of contiguous wind sectors have similar effects on flow paths in the vicinity of the beaches. In addition, reverse particle tracking was used for transient conditions to identify expected flow paths for 10 E. coli sampling events in 2004. These results demonstrate the ability to track hypothetical particles from the beaches, backward in time, to likely source areas. This ability, coupled with a greater frequency of bacteria sampling, may provide insight into changes in bacteria concentrations between source and sink areas.

Correlational signatures of time-reversal symmetry breaking in two-dimensional flow

NASA Astrophysics Data System (ADS)

Hogg, Charlie; Ouellette, Nicholas

2015-11-01

Classical turbulence theories posit that broken spatial symmetries should be (statistically) restored at small scales. But since turbulent flows are inherently dissipative, time reversal symmetry is expected to remain broken throughout the cascade. However, the precise dynamical signature of this broken symmetry is not well understood. Recent work has shed new light on this fundamental question by considering the Lagrangian structure functions of power. Here, we take a somewhat different approach by studying the Lagrangian correlation functions of velocity and acceleration. We measured these correlations using particle tracking velocimetry in a quasi-two-dimensional electromagnetically driven flow that displayed net inverse energy transfer. We show that the correlation functions of the velocity and acceleration magnitudes are not symmetric in time, and that the degree of asymmetry can be related to the flux of energy between scales, suggesting that the asymmetry has a dynamical origin.

Tracking and people counting using Particle Filter Method

NASA Astrophysics Data System (ADS)

Sulistyaningrum, D. R.; Setiyono, B.; Rizky, M. S.

2018-03-01

In recent years, technology has developed quite rapidly, especially in the field of object tracking. Moreover, if the object under study is a person and the number of people a lot. The purpose of this research is to apply Particle Filter method for tracking and counting people in certain area. Tracking people will be rather difficult if there are some obstacles, one of which is occlusion. The stages of tracking and people counting scheme in this study include pre-processing, segmentation using Gaussian Mixture Model (GMM), tracking using particle filter, and counting based on centroid. The Particle Filter method uses the estimated motion included in the model used. The test results show that the tracking and people counting can be done well with an average accuracy of 89.33% and 77.33% respectively from six videos test data. In the process of tracking people, the results are good if there is partial occlusion and no occlusion

Ghost hunting—an assessment of ghost particle detection and removal methods for tomographic-PIV

NASA Astrophysics Data System (ADS)

Elsinga, G. E.; Tokgoz, S.

2014-08-01

This paper discusses and compares several methods, which aim to remove spurious peaks, i.e. ghost particles, from the volume intensity reconstruction in tomographic-PIV. The assessment is based on numerical simulations of time-resolved tomographic-PIV experiments in linear shear flows. Within the reconstructed volumes, intensity peaks are detected and tracked over time. These peaks are associated with particles (either ghosts or actual particles) and are characterized by their peak intensity, size and track length. Peak intensity and track length are found to be effective in discriminating between most ghosts and the actual particles, although not all ghosts can be detected using only a single threshold. The size of the reconstructed particles does not reveal an important difference between ghosts and actual particles. The joint distribution of peak intensity and track length however does, under certain conditions, allow a complete separation of ghosts and actual particles. The ghosts can have either a high intensity or a long track length, but not both combined, like all the actual particles. Removing the detected ghosts from the reconstructed volume and performing additional MART iterations can decrease the particle position error at low to moderate seeding densities, but increases the position error, velocity error and tracking errors at higher densities. The observed trends in the joint distribution of peak intensity and track length are confirmed by results from a real experiment in laminar Taylor-Couette flow. This diagnostic plot allows an estimate of the number of ghosts that are indistinguishable from the actual particles.

Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields.

PubMed

Patel, Mohak; Leggett, Susan E; Landauer, Alexander K; Wong, Ian Y; Franck, Christian

2018-04-03

Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing tracking algorithms are most effective for relatively low numbers of particles that undergo displacements smaller than their typical interparticle separation distance. Here, we demonstrate a single particle tracking algorithm to reconstruct large complex motion fields with large particle numbers, orders of magnitude larger than previously tractably resolvable, thus opening the door for attaining very high Nyquist spatial frequency motion recovery in the images. Our key innovations are feature vectors that encode nearest neighbor positions, a rigorous outlier removal scheme, and an iterative deformation warping scheme. We test this technique for its accuracy and computational efficacy using synthetically and experimentally generated 3D particle images, including non-affine deformation fields in soft materials, complex fluid flows, and cell-generated deformations. We augment this algorithm with additional particle information (e.g., color, size, or shape) to further enhance tracking accuracy for high gradient and large displacement fields. These applications demonstrate that this versatile technique can rapidly track unprecedented numbers of particles to resolve large and complex motion fields in 2D and 3D images, particularly when spatial correlations exist.

Adaptive particle filter for robust visual tracking

NASA Astrophysics Data System (ADS)

Dai, Jianghua; Yu, Shengsheng; Sun, Weiping; Chen, Xiaoping; Xiang, Jinhai

2009-10-01

Object tracking plays a key role in the field of computer vision. Particle filter has been widely used for visual tracking under nonlinear and/or non-Gaussian circumstances. In particle filter, the state transition model for predicting the next location of tracked object assumes the object motion is invariable, which cannot well approximate the varying dynamics of the motion changes. In addition, the state estimate calculated by the mean of all the weighted particles is coarse or inaccurate due to various noise disturbances. Both these two factors may degrade tracking performance greatly. In this work, an adaptive particle filter (APF) with a velocity-updating based transition model (VTM) and an adaptive state estimate approach (ASEA) is proposed to improve object tracking. In APF, the motion velocity embedded into the state transition model is updated continuously by a recursive equation, and the state estimate is obtained adaptively according to the state posterior distribution. The experiment results show that the APF can increase the tracking accuracy and efficiency in complex environments.

Optical tracking of nanoscale particles in microscale environments

NASA Astrophysics Data System (ADS)

Mathai, P. P.; Liddle, J. A.; Stavis, S. M.

2016-03-01

The trajectories of nanoscale particles through microscale environments record useful information about both the particles and the environments. Optical microscopes provide efficient access to this information through measurements of light in the far field from nanoparticles. Such measurements necessarily involve trade-offs in tracking capabilities. This article presents a measurement framework, based on information theory, that facilitates a more systematic understanding of such trade-offs to rationally design tracking systems for diverse applications. This framework includes the degrees of freedom of optical microscopes, which determine the limitations of tracking measurements in theory. In the laboratory, tracking systems are assemblies of sources and sensors, optics and stages, and nanoparticle emitters. The combined characteristics of such systems determine the limitations of tracking measurements in practice. This article reviews this tracking hardware with a focus on the essential functions of nanoparticles as optical emitters and microenvironmental probes. Within these theoretical and practical limitations, experimentalists have implemented a variety of tracking systems with different capabilities. This article reviews a selection of apparatuses and techniques for tracking multiple and single particles by tuning illumination and detection, and by using feedback and confinement to improve the measurements. Prior information is also useful in many tracking systems and measurements, which apply across a broad spectrum of science and technology. In the context of the framework and review of apparatuses and techniques, this article reviews a selection of applications, with particle diffusion serving as a prelude to tracking measurements in biological, fluid, and material systems, fabrication and assembly processes, and engineered devices. In so doing, this review identifies trends and gaps in particle tracking that might influence future research.

Micro-heterogeneity of corn hulls cellulosic fiber biopolymer studied by multiple-particle tracking (MPT)

USDA-ARS?s Scientific Manuscript database

A novel technique named multiple-particle tracking (MPT) was used to investigate the micro-structural heterogeneities of Z-trim, a zero calorie cellulosic fiber biopolymer produced from corn hulls. The Multiple-Particle Tracking (MPT) method was used in this study, which was originally described by ...

A high-speed tracking algorithm for dense granular media

NASA Astrophysics Data System (ADS)

Cerda, Mauricio; Navarro, Cristóbal A.; Silva, Juan; Waitukaitis, Scott R.; Mujica, Nicolás; Hitschfeld, Nancy

2018-06-01

Many fields of study, including medical imaging, granular physics, colloidal physics, and active matter, require the precise identification and tracking of particle-like objects in images. While many algorithms exist to track particles in diffuse conditions, these often perform poorly when particles are densely packed together-as in, for example, solid-like systems of granular materials. Incorrect particle identification can have significant effects on the calculation of physical quantities, which makes the development of more precise and faster tracking algorithms a worthwhile endeavor. In this work, we present a new tracking algorithm to identify particles in dense systems that is both highly accurate and fast. We demonstrate the efficacy of our approach by analyzing images of dense, solid-state granular media, where we achieve an identification error of 5% in the worst evaluated cases. Going further, we propose a parallelization strategy for our algorithm using a GPU, which results in a speedup of up to 10 × when compared to a sequential CPU implementation in C and up to 40 × when compared to the reference MATLAB library widely used for particle tracking. Our results extend the capabilities of state-of-the-art particle tracking methods by allowing fast, high-fidelity detection in dense media at high resolutions.

Decorrelation correction for nanoparticle tracking analysis of dilute polydisperse suspensions in bulk flow

NASA Astrophysics Data System (ADS)

Hartman, John; Kirby, Brian

2017-03-01

Nanoparticle tracking analysis, a multiprobe single particle tracking technique, is a widely used method to quickly determine the concentration and size distribution of colloidal particle suspensions. Many popular tools remove non-Brownian components of particle motion by subtracting the ensemble-average displacement at each time step, which is termed dedrifting. Though critical for accurate size measurements, dedrifting is shown here to introduce significant biasing error and can fundamentally limit the dynamic range of particle size that can be measured for dilute heterogeneous suspensions such as biological extracellular vesicles. We report a more accurate estimate of particle mean-square displacement, which we call decorrelation analysis, that accounts for correlations between individual and ensemble particle motion, which are spuriously introduced by dedrifting. Particle tracking simulation and experimental results show that this approach more accurately determines particle diameters for low-concentration polydisperse suspensions when compared with standard dedrifting techniques.

Optical tracking of nanoscale particles in microscale environments

PubMed Central

Mathai, P. P.; Liddle, J. A.; Stavis, S. M.

2016-01-01

The trajectories of nanoscale particles through microscale environments record useful information about both the particles and the environments. Optical microscopes provide efficient access to this information through measurements of light in the far field from nanoparticles. Such measurements necessarily involve trade-offs in tracking capabilities. This article presents a measurement framework, based on information theory, that facilitates a more systematic understanding of such trade-offs to rationally design tracking systems for diverse applications. This framework includes the degrees of freedom of optical microscopes, which determine the limitations of tracking measurements in theory. In the laboratory, tracking systems are assemblies of sources and sensors, optics and stages, and nanoparticle emitters. The combined characteristics of such systems determine the limitations of tracking measurements in practice. This article reviews this tracking hardware with a focus on the essential functions of nanoparticles as optical emitters and microenvironmental probes. Within these theoretical and practical limitations, experimentalists have implemented a variety of tracking systems with different capabilities. This article reviews a selection of apparatuses and techniques for tracking multiple and single particles by tuning illumination and detection, and by using feedback and confinement to improve the measurements. Prior information is also useful in many tracking systems and measurements, which apply across a broad spectrum of science and technology. In the context of the framework and review of apparatuses and techniques, this article reviews a selection of applications, with particle diffusion serving as a prelude to tracking measurements in biological, fluid, and material systems, fabrication and assembly processes, and engineered devices. In so doing, this review identifies trends and gaps in particle tracking that might influence future research. PMID:27213022

Magnetic particle tracking for nonspherical particles in a cylindrical fluidized bed.

PubMed

Buist, Kay A; Jayaprakash, Pavithra; Kuipers, J A M; Deen, Niels G; Padding, Johan T

2017-12-01

In granular flow operations, often particles are nonspherical. This has inspired a vast amount of research in understanding the behavior of these particles. Various models are being developed to study the hydrodynamics involving nonspherical particles. Experiments however are often limited to obtain data on the translational motion only. This paper focusses on the unique capability of Magnetic Particle Tracking to track the orientation of a marker in a full 3-D cylindrical fluidized bed. Stainless steel particles with the same volume and different aspect ratios are fluidized at a range of superficial gas velocities. Spherical and rod-like particles show distinctly different fluidization behavior. Also, the distribution of angles for rod-like particles changes with position in the fluidized bed as well as with the superficial velocity. Magnetic Particle Tracking shows its unique capability to study both spatial distribution and orientation of the particles allowing more in-depth validation of Discrete Particle Models. © 2017 The Authors AIChE Journal published by Wiley Periodicals, Inc. on behalf of American Institute of Chemical Engineers , 63: 5335-5342, 2017.

Relationship between axenic growth of Dictyostelium discoideum strains and their track morphology on substrates coated with gold particles

PubMed Central

1983-01-01

Amoebae of Dictyostelium discoideum produce tracks with two distinct morphologies on gold-coated coverslips. The wild-type strain and other strains that feed only by phagocytosis produced indistinct, fuzzy tracks, whereas mutants capable of axenic growth produced clear, sharp tracks. The sharp track morphology was found to be a recessive phenotype that segregates with axenicity and probably requires a previously unidentified axenic mutation. Axenic and nonaxenic strains also differed in their ability to pinocytose. When the two types of cells were shifted from bacterial growth plates to nutrient media, within 24 h the axenic strain established a rapid rate of pinocytosis, approximately 100-fold higher than the low rate detectable for the nonaxenic strain. However, track formation did not appear to be directly related to endocytosis. Electron microscopic examination of cells during track formation showed that both axenic and nonaxenic strains accumulated gold particles on their surfaces, but neither strain internalized the gold to any significant degree. Observation of living cells revealed that axenic strains collected all particles that they contacted, whereas wild-type strains left many particles undisturbed. The size of the gold particle clusters discarded by the cells also contributed to track morphology. PMID:6619183

Symplectic orbit and spin tracking code for all-electric storage rings

DOE PAGES

Talman, Richard M.; Talman, John D.

2015-07-22

Proposed methods for measuring the electric dipole moment (EDM) of the proton use an intense, polarized proton beam stored in an all-electric storage ring “trap.” At the “magic” kinetic energy of 232.792 MeV, proton spins are “frozen,” for example always parallel to the instantaneous particle momentum. Energy deviation from the magic value causes in-plane precession of the spin relative to the momentum. Any nonzero EDM value will cause out-of-plane precession—measuring this precession is the basis for the EDM determination. A proposed implementation of this measurement shows that a proton EDM value of 10 –29e–cm or greater will produce a statisticallymore » significant, measurable precession after multiply repeated runs, assuming small beam depolarization during 1000 s runs, with high enough precision to test models of the early universe developed to account for the present day particle/antiparticle population imbalance. This paper describes an accelerator simulation code, eteapot, a new component of the Unified Accelerator Libraries (ual), to be used for long term tracking of particle orbits and spins in electric bend accelerators, in order to simulate EDM storage ring experiments. Though qualitatively much like magnetic rings, the nonconstant particle velocity in electric rings gives them significantly different properties, especially in weak focusing rings. Like the earlier code teapot (for magnetic ring simulation) this code performs exact tracking in an idealized (approximate) lattice rather than the more conventional approach, which is approximate tracking in a more nearly exact lattice. The Bargmann-Michel-Telegdi (BMT) equation describing the evolution of spin vectors through idealized bend elements is also solved exactly—original to this paper. Furthermore the idealization permits the code to be exactly symplectic (with no artificial “symplectification”). Any residual spurious damping or antidamping is sufficiently small to permit reliable tracking for the long times, such as the 1000 s assumed in estimating the achievable EDM precision. This paper documents in detail the theoretical formulation implemented in eteapot. An accompanying paper describes the practical application of the eteapot code in the Universal Accelerator Libraries (ual) environment to “resurrect,” or reverse engineer, the “AGS-analog” all-electric ring built at Brookhaven National Laboratory in 1954. Of the (very few) all-electric rings ever commissioned, the AGS-analog ring is the only relativistic one and is the closest to what is needed for measuring proton (or, even more so, electron) EDM’s. As a result, the companion paper also describes preliminary lattice studies for the planned proton EDM storage rings as well as testing the code for long time orbit and spin tracking.« less

Streaming reversal of energetic particles in the magnetotail during a substorm

NASA Technical Reports Server (NTRS)

Lui, A. T. Y.; Williams, D. J.; Eastman, T. E.; Frank, L. A.; Akasofu, S.-I.

1984-01-01

A case of reversal in the streaming anisotropy of energetic ions and in the plasma flow observed from the IMP 8 spacecraft during a substorm on February 8, 1978 is studied in detail using measurements of energetic particles, plasma, and magnetic field. Four new features emerge when high time resolution data are examined in detail. The times of streaming reversal of energetic particles in different energy ranges do not coincide with the time of plasma flow reversal. Qualitatively different velocity distributions are observed in earthward and tailward plasma flows during the observed flow reversal intervals. Strong tailward streaming of energetic particles can be detected during northward magnetic field environments and, conversely, earthward streaming in southward field environments. During the period of tailward streaming of energetic particles, earthward streaming fluxes are occasionally detected.

Exploring dynamics in living cells by tracking single particles.

PubMed

Levi, Valeria; Gratton, Enrico

2007-01-01

In the last years, significant advances in microscopy techniques and the introduction of a novel technology to label living cells with genetically encoded fluorescent proteins revolutionized the field of Cell Biology. Our understanding on cell dynamics built from snapshots on fixed specimens has evolved thanks to our actual capability to monitor in real time the evolution of processes in living cells. Among these new tools, single particle tracking techniques were developed to observe and follow individual particles. Hence, we are starting to unravel the mechanisms driving the motion of a wide variety of cellular components ranging from organelles to protein molecules by following their way through the cell. In this review, we introduce the single particle tracking technology to new users. We briefly describe the instrumentation and explain some of the algorithms commonly used to locate and track particles. Also, we present some common tools used to analyze trajectories and illustrate with some examples the applications of single particle tracking to study dynamics in living cells.

Fuzzy logic particle tracking velocimetry

NASA Technical Reports Server (NTRS)

Wernet, Mark P.

1993-01-01

Fuzzy logic has proven to be a simple and robust method for process control. Instead of requiring a complex model of the system, a user defined rule base is used to control the process. In this paper the principles of fuzzy logic control are applied to Particle Tracking Velocimetry (PTV). Two frames of digitally recorded, single exposure particle imagery are used as input. The fuzzy processor uses the local particle displacement information to determine the correct particle tracks. Fuzzy PTV is an improvement over traditional PTV techniques which typically require a sequence (greater than 2) of image frames for accurately tracking particles. The fuzzy processor executes in software on a PC without the use of specialized array or fuzzy logic processors. A pair of sample input images with roughly 300 particle images each, results in more than 200 velocity vectors in under 8 seconds of processing time.

Cosmic ray particle dosimetry and trajectory tracing. [cosmic ray track analysis for Apollo 17 BIOCORE

NASA Technical Reports Server (NTRS)

Cruty, M. R.; Benton, E. V.; Turnbill, C. E.; Philpott, D. E.

1975-01-01

Five pocket mice (Perognathus longimembris) were flown on Apollo XVII, each with a solid-state (plastic) nuclear track detector implanted beneath its scalp. The subscalp detectors were sensitive to HZE cosmic ray particles with a LET greater than or approximately equal to 0.15 million electron volts per micrometer (MeV/micron). A critical aspect of the dosimetry of the experiment involved tracing individual particle trajectories through each mouse head from particle tracks registered in the individual subscalp detectors, thereby establishing a one-to-one correspondence between a trajectory location in the tissue and the presence or absence of a lesion. The other major aspect was the identification of each registered particle. An average of 16 particles with Z greater than or equal to 6 and 2.2 particles with Z greater than or equal to 20 were found per detector. The track density, 29 tracks/sq cm, when adjusted for detection volume, was in agreement with the photographic emulsion data from an area dosimeter located next to the flight package.

Chemistry and particle track studies of Apollo 14 glasses.

NASA Technical Reports Server (NTRS)

Glass, B. P.; Storzer, D.; Wagner, G. A.

1972-01-01

The abundance and the composition of Apollo 14 glasses have been studied. Glass particles were analyzed for Si, Ti, Al, Fe, Mn, Mg, Na, and K by electron microprobe analysis. The refractive indices of 26 particles were determined by the oil immersion method. Track analyses have been carried out in order to determine the uranium content and the radiation history of glass particles. The proper identification of galactic and solar flare nuclei tracks makes it possible to estimated residence times of the glass particles in the top layer of the lunar soil.

Modeling the solute transport by particle-tracing method with variable weights

NASA Astrophysics Data System (ADS)

Jiang, J.

2016-12-01

Particle-tracing method is usually used to simulate the solute transport in fracture media. In this method, the concentration at one point is proportional to number of particles visiting this point. However, this method is rather inefficient at the points with small concentration. Few particles visit these points, which leads to violent oscillation or gives zero value of concentration. In this paper, we proposed a particle-tracing method with variable weights. The concentration at one point is proportional to the sum of the weights of the particles visiting it. It adjusts the weight factors during simulations according to the estimated probabilities of corresponding walks. If the weight W of a tracking particle is larger than the relative concentration C at the corresponding site, the tracking particle will be splitted into Int(W/C) copies and each copy will be simulated independently with the weight W/Int(W/C) . If the weight W of a tracking particle is less than the relative concentration C at the corresponding site, the tracking particle will be continually tracked with a probability W/C and the weight will be adjusted to be C. By adjusting weights, the number of visiting particles distributes evenly in the whole range. Through this variable weights scheme, we can eliminate the violent oscillation and increase the accuracy of orders of magnitudes.

MEASURING PROJECTOR

DOEpatents

Franck, J.V.; Broadhead, P.S.; Skiff, E.W.

1959-07-14

A semiautomatic measuring projector particularly adapted for measurement of the coordinates of photographic images of particle tracks as prcduced in a bubble or cloud chamber is presented. A viewing screen aids the operator in selecting a particle track for measurement. After approximate manual alignment, an image scanning system coupled to a servo control provides automatic exact alignment of a track image with a reference point. The apparatus can follow along a track with a continuous motion while recording coordinate data at various selected points along the track. The coordinate data is recorded on punched cards for subsequent computer calculation of particle trajectory, momentum, etc.

Time-resolved large-scale volumetric pressure fields of an impinging jet from dense Lagrangian particle tracking

NASA Astrophysics Data System (ADS)

Huhn, F.; Schanz, D.; Manovski, P.; Gesemann, S.; Schröder, A.

2018-05-01

Time-resolved volumetric pressure fields are reconstructed from Lagrangian particle tracking with high seeding concentration using the Shake-The-Box algorithm in a perpendicular impinging jet flow with exit velocity U=4 m/s (Re˜ 36,000) and nozzle-plate spacing H/D=5. Helium-filled soap bubbles are used as tracer particles which are illuminated with pulsed LED arrays. A large measurement volume has been covered (cloud of tracked particles in a volume of 54 L, ˜ 180,000 particles). The reconstructed pressure field has been validated against microphone recordings at the wall with high correlation coefficients up to 0.88. In a reduced measurement volume (13 L), dense Lagrangian particle tracking is shown to be feasable up to the maximal possible jet velocity of U=16 m/s.

Development of a real-time internal and external marker tracking system for particle therapy: a phantom study using patient tumor trajectory data

PubMed Central

Cho, Junsang; Cheon, Wonjoong; Ahn, Sanghee; Jung, Hyunuk; Sheen, Heesoon; Park, Hee Chul

2017-01-01

Abstract Target motion–induced uncertainty in particle therapy is more complicated than that in X-ray therapy, requiring more accurate motion management. Therefore, a hybrid motion-tracking system that can track internal tumor motion and as well as an external surrogate of tumor motion was developed. Recently, many correlation tests between internal and external markers in X-ray therapy have been developed; however, the accuracy of such internal/external marker tracking systems, especially in particle therapy, has not yet been sufficiently tested. In this article, the process of installing an in-house hybrid internal/external motion-tracking system is described and the accuracy level of tracking system was acquired. Our results demonstrated that the developed in-house external/internal combined tracking system has submillimeter accuracy, and can be clinically used as a particle therapy system as well as a simulation system for moving tumor treatment. PMID:28201522

PSO Algorithm Particle Filters for Improving the Performance of Lane Detection and Tracking Systems in Difficult Roads

PubMed Central

Cheng, Wen-Chang

2012-01-01

In this paper we propose a robust lane detection and tracking method by combining particle filters with the particle swarm optimization method. This method mainly uses the particle filters to detect and track the local optimum of the lane model in the input image and then seeks the global optimal solution of the lane model by a particle swarm optimization method. The particle filter can effectively complete lane detection and tracking in complicated or variable lane environments. However, the result obtained is usually a local optimal system status rather than the global optimal system status. Thus, the particle swarm optimization method is used to further refine the global optimal system status in all system statuses. Since the particle swarm optimization method is a global optimization algorithm based on iterative computing, it can find the global optimal lane model by simulating the food finding way of fish school or insects under the mutual cooperation of all particles. In verification testing, the test environments included highways and ordinary roads as well as straight and curved lanes, uphill and downhill lanes, lane changes, etc. Our proposed method can complete the lane detection and tracking more accurately and effectively then existing options. PMID:23235453

Effects of orbitofrontal cortex lesions on autoshaped lever pressing and reversal learning.

PubMed

Chang, Stephen E

2014-10-15

A cue associated with a rewarding event can trigger behavior towards the cue itself due to the cue acquiring incentive value through its pairing with the rewarding outcome (i.e., sign-tracking). For example, rats will approach, press, and attempt to "consume" a retractable lever conditioned stimulus (CS) that signals delivery of a food unconditioned stimulus (US). Attending to food-predictive CSs is important when seeking out food, and it is just as important to be able to modify one's behavior when the relationships between CSs and USs are changed. Using a discriminative autoshaping procedure with lever CSs, the present study investigated the effects of orbitofrontal cortex (OFC) lesions on sign-tracking and reversal learning. Insertion of one lever was followed by sucrose delivery upon retraction, and insertion of another lever was followed by nothing. After the acquisition phase, the contingencies between the levers and outcomes were reversed. Bilateral OFC lesions had no effect on the acquisition of sign-tracking. However, OFC-lesioned rats showed substantial deficits in acquiring sign-tracking compared to sham-lesioned rats once the stimulus-outcome contingencies were reversed. Over the course of reversal learning, OFC-lesioned rats were able to reach comparable levels of sign-tracking as sham-lesioned rats. These findings suggest that OFC is not necessary for the ability of a CS to acquire incentive value and provide more evidence that OFC is critical for modifying behavior appropriately following a change in stimulus-outcome contingencies. Copyright © 2014 Elsevier B.V. All rights reserved.

Stardust Interstellar Preliminary Examination V: XRF Analyses of Interstellar Dust Candidates at ESRF ID13

NASA Technical Reports Server (NTRS)

Brenker, Frank E.; Westphal, Andrew J.; Simionovici, Alexandre S.; Flynn, George J.; Gainsforth, Zack; Allen, Carlton C.; Sanford, Scott; Zolensky, Michael E.; Bastien, Ron K.; Frank, David R.

2014-01-01

Here, we report analyses by synchrotron X-ray fluorescence microscopy of the elemental composition of eight candidate impact features extracted from the Stardust Interstellar Dust Collector (SIDC). Six of the features were unambiguous tracks, and two were crater-like features. Five of the tracks are so-called midnight tracks that is, they had trajectories consistent with an origin either in the interstellar dust stream or as secondaries from impacts on the Sample Return Capsule (SRC). In a companion paper reporting synchrotron X-ray diffraction analyses of ISPE candidates, we show that two of these particles contain natural crystalline materials: the terminal particle of track 30contains olivine and spinel, and the terminal particle of track 34 contains olivine. Here, we show that the terminal particle of track 30, Orion, shows elemental abundances, normalized to Fe, that are close to CI values, and a complex, fine-grained structure. The terminal particle of track 34, Hylabrook, shows abundances that deviate strongly from CI, but shows little fine structure and is nearly homogenous. The terminal particles of other midnight tracks, 29 and 37, had heavy element abundances below detection threshold. A third, track28, showed a composition inconsistent with an extraterrestrial origin, but also inconsistent with known spacecraft materials. A sixth track, with a trajectory consistent with secondary ejecta from an impact on one of the spacecraft solar panels, contains abundant Ce and Zn. This is consistent with the known composition of the glass covering the solar panel. Neither crater-like feature is likely to be associated with extraterrestrial materials. We also analyzed blank aerogel samples to characterize background and variability between aerogel tiles. We found significant differences in contamination levels and compositions, emphasizing the need for local background subtraction for accurate quantification.

Using Image Attributes to Assure Accurate Particle Size and Count Using Nanoparticle Tracking Analysis.

PubMed

Defante, Adrian P; Vreeland, Wyatt N; Benkstein, Kurt D; Ripple, Dean C

2018-05-01

Nanoparticle tracking analysis (NTA) obtains particle size by analysis of particle diffusion through a time series of micrographs and particle count by a count of imaged particles. The number of observed particles imaged is controlled by the scattering cross-section of the particles and by camera settings such as sensitivity and shutter speed. Appropriate camera settings are defined as those that image, track, and analyze a sufficient number of particles for statistical repeatability. Here, we test if image attributes, features captured within the image itself, can provide measurable guidelines to assess the accuracy for particle size and count measurements using NTA. The results show that particle sizing is a robust process independent of image attributes for model systems. However, particle count is sensitive to camera settings. Using open-source software analysis, it was found that a median pixel area, 4 pixels 2 , results in a particle concentration within 20% of the expected value. The distribution of these illuminated pixel areas can also provide clues about the polydispersity of particle solutions prior to using a particle tracking analysis. Using the median pixel area serves as an operator-independent means to assess the quality of the NTA measurement for count. Published by Elsevier Inc.

PLGA-Based Nanoparticles: a Safe and Suitable Delivery Platform for Osteoarticular Pathologies.

PubMed

Riffault, Mathieu; Six, Jean-Luc; Netter, Patrick; Gillet, Pierre; Grossin, Laurent

2015-12-01

Despite the promising applications of PLGA based particles, studies examining the fate and consequences of these particles after intra-articular administration in the joint are scanty. This study was carried out to evaluate the neutrality of the unloaded delivery system on different articular cell types. To facilitate tracking, we have thus developed a fluorescent core of particles, combined to a hyaluronate shell for cell recognition. Fluorescence pictures were taken at time intervals to assess the internalization and the corresponding inflammatory response was monitored by RT-qPCR and biochemical measurements. After NPs pre-treatment, mesenchymal stem cells (MSCs) were cultured into chondrogenic, adipogenic or osteogenic differentiation media, to investigate if NPs exposure interferes with differentiation ability. Finally, intra-articular injections were performed in healthy rat knees and joint's structure analysed by histological studies. Particles were detected in cytoplasm 8 h after exposure. Internalization led to a slight and reversible increase of inflammatory markers, but lower than in inflammatory conditions. We have confirmed particles exposure minimal neutrality on MSCs pluripotency. Histological exams of joint after intra-articular injections do not demonstrate any side effects of NPs. Our findings suggest that such a delivery platform is well tolerated locally and could be used to deliver active molecules to the joint.

An automatic, stagnation point based algorithm for the delineation of Wellhead Protection Areas

NASA Astrophysics Data System (ADS)

Tosco, Tiziana; Sethi, Rajandrea; di Molfetta, Antonio

2008-07-01

Time-related capture areas are usually delineated using the backward particle tracking method, releasing circles of equally spaced particles around each well. In this way, an accurate delineation often requires both a very high number of particles and a manual capture zone encirclement. The aim of this work was to propose an Automatic Protection Area (APA) delineation algorithm, which can be coupled with any model of flow and particle tracking. The computational time is here reduced, thanks to the use of a limited number of nonequally spaced particles. The particle starting positions are determined coupling forward particle tracking from the stagnation point, and backward particle tracking from the pumping well. The pathlines are postprocessed for a completely automatic delineation of closed perimeters of time-related capture zones. The APA algorithm was tested for a two-dimensional geometry, in homogeneous and nonhomogeneous aquifers, steady state flow conditions, single and multiple wells. Results show that the APA algorithm is robust and able to automatically and accurately reconstruct protection areas with a very small number of particles, also in complex scenarios.

Markerless human motion tracking using hierarchical multi-swarm cooperative particle swarm optimization.

PubMed

Saini, Sanjay; Zakaria, Nordin; Rambli, Dayang Rohaya Awang; Sulaiman, Suziah

2015-01-01

The high-dimensional search space involved in markerless full-body articulated human motion tracking from multiple-views video sequences has led to a number of solutions based on metaheuristics, the most recent form of which is Particle Swarm Optimization (PSO). However, the classical PSO suffers from premature convergence and it is trapped easily into local optima, significantly affecting the tracking accuracy. To overcome these drawbacks, we have developed a method for the problem based on Hierarchical Multi-Swarm Cooperative Particle Swarm Optimization (H-MCPSO). The tracking problem is formulated as a non-linear 34-dimensional function optimization problem where the fitness function quantifies the difference between the observed image and a projection of the model configuration. Both the silhouette and edge likelihoods are used in the fitness function. Experiments using Brown and HumanEva-II dataset demonstrated that H-MCPSO performance is better than two leading alternative approaches-Annealed Particle Filter (APF) and Hierarchical Particle Swarm Optimization (HPSO). Further, the proposed tracking method is capable of automatic initialization and self-recovery from temporary tracking failures. Comprehensive experimental results are presented to support the claims.

Particle Tracking Model (PTM) with Coastal Modeling System (CMS)

DTIC Science & Technology

2015-11-04

Coastal Inlets Research Program Particle Tracking Model (PTM) with Coastal Modeling System ( CMS ) The Particle Tracking Model (PTM) is a Lagrangian...currents and waves. The Coastal Inlets Research Program (CIRP) supports the PTM with the Coastal Modeling System ( CMS ), which provides coupled wave...and current forcing for PTM simulations. CMS -PTM is implemented in the Surface-water Modeling System, a GUI environment for input development

Alpha particle spectroscopy using FNTD and SIM super-resolution microscopy.

PubMed

Kouwenberg, J J M; Kremers, G J; Slotman, J A; Wolterbeek, H T; Houtsmuller, A B; Denkova, A G; Bos, A J J

2018-06-01

Structured illumination microscopy (SIM) for the imaging of alpha particle tracks in fluorescent nuclear track detectors (FNTD) was evaluated and compared to confocal laser scanning microscopy (CLSM). FNTDs were irradiated with an external alpha source and imaged using both methodologies. SIM imaging resulted in improved resolution, without increase in scan time. Alpha particle energy estimation based on the track length, direction and intensity produced results in good agreement with the expected alpha particle energy distribution. A pronounced difference was seen in the spatial scattering of alpha particles in the detectors, where SIM showed an almost 50% reduction compared to CLSM. The improved resolution of SIM allows for more detailed studies of the tracks induced by ionising particles. The combination of SIM and FNTDs for alpha radiation paves the way for affordable and fast alpha spectroscopy and dosimetry. © 2018 The Authors. Journal of Microscopy published by JohnWiley & Sons Ltd on behalf of Royal Microscopical Society.

Scintillator-fiber charged particle track-imaging detector

NASA Technical Reports Server (NTRS)

Binns, W. R.; Israel, M. H.; Klarmann, J.

1983-01-01

A scintillator-fiber charged-particle track-imaging detector was developed using a bundle of square cross section plastic scintillator fiber optics, proximity focused onto an image intensified charge injection device (CID) camera. The tracks of charged particle penetrating into the scintillator fiber bundle are projected onto the CID camera and the imaging information is read out in video format. The detector was exposed to beams of 15 MeV protons and relativistic Neon, Manganese, and Gold nuclei and images of their tracks were obtained. Details of the detector technique, properties of the tracks obtained, and preliminary range measurements of 15 MeV protons stopping in the fiber bundle are presented.

PIV Analysis Comparing Aerodynamic Downforce Devices on Race Car in Water Tunnel

NASA Astrophysics Data System (ADS)

Hellman, Sam; Tkacik, Peter; Uddin, Mesbah; Kelly, Scott

2010-11-01

There have been claims that the rear wing on the NASCAR Car of Tomorrow (COT) race car causes lift in the condition where the car spins during a crash and is traveling backwards down the track at a high rate of speed. When enough lift is generated, the race car can lose control and even fly off of the track surface completely. To address this concern, a new rear spoiler was designed by NASCAR to replace the wing and prevent this dangerous condition. Flow characteristics of both the rear wing and the new spoiler are qualitatively analyzed using particle image velocimetry (PIV). The experiment is done in a continuous flow water tunnel using a simplified 10% scale model COT. Flow structures are identified and compared for both the wing and spoiler. The same conditions are also reviewed when the car is traveling backwards as it might during a crash. The cause of the lift generated by the rear wing when in reverse is shown.

Tracking Virus Particles in Fluorescence Microscopy Images Using Multi-Scale Detection and Multi-Frame Association.

PubMed

Jaiswal, Astha; Godinez, William J; Eils, Roland; Lehmann, Maik Jorg; Rohr, Karl

2015-11-01

Automatic fluorescent particle tracking is an essential task to study the dynamics of a large number of biological structures at a sub-cellular level. We have developed a probabilistic particle tracking approach based on multi-scale detection and two-step multi-frame association. The multi-scale detection scheme allows coping with particles in close proximity. For finding associations, we have developed a two-step multi-frame algorithm, which is based on a temporally semiglobal formulation as well as spatially local and global optimization. In the first step, reliable associations are determined for each particle individually in local neighborhoods. In the second step, the global spatial information over multiple frames is exploited jointly to determine optimal associations. The multi-scale detection scheme and the multi-frame association finding algorithm have been combined with a probabilistic tracking approach based on the Kalman filter. We have successfully applied our probabilistic tracking approach to synthetic as well as real microscopy image sequences of virus particles and quantified the performance. We found that the proposed approach outperforms previous approaches.

Magnetization Reversal Process of Single Crystal α-Fe Containing a Nonmagnetic Particle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yi; Xu, Ben; Hu, Shenyang Y.

2015-09-25

The magnetization reversal process and hysteresis loops in a single crystal α-iron with nonmagnetic particles are simulated in this work based on the Landau-Lifshitz–Gilbert equation. The evolutions of the magnetic domain morphology are studied, and our analyses show that the magnetization reversal process is affected by the interaction between the moving domain wall and the existing nonmagnetic particles. This interaction strongly depends on the size of the particles, and it is found that particles with a particular size contribute the most to magnetic hardening.

3D laser traking of a particle in 3DFM

NASA Astrophysics Data System (ADS)

Desai, Kalpit; Welch, Gregory; Bishop, Gary; Taylor, Russell; Superfine, Richard

2003-11-01

The principal goal of 3D tracking in our home-built 3D Magnetic Force Microscope is to monitor movement of the particle with respect to laser beam waist and keep the particle at the center of laser beam. The sensory element is a Quadrant Photo Diode (QPD) which captures scattering of light caused by particle motion with bandwidth up to 40 KHz. XYZ translation stage is the driver element which moves particle back in the center of the laser with accuracy of couple of nanometers and with bandwidth up to 300 Hz. Since our particles vary in size, composition and shape, instead of using a priori model we use standard system identification techniques to have optimal approximation to the relationship between particle motion and QPD response. We have developed position feedback control system software that is capable of 3-dimensional tracking of beads that are attached to cilia on living cells which are beating at up to 15Hz. We have also modeled the control system of instrument to simulate performance of 3D particle tracking for different experimental conditions. Given operational level of nanometers, noise poses a great challenge for the tracking system. We propose to use stochastic control theory approaches to increase robustness of tracking.

Infrared Spectroscopy of Wild 2 Particle Hypervelocity Tracks in Stardust Aerogel: Evidence for the presence of Volatile Organics in Comet Dust

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bajt, S; Sandford, S A; Flynn, G J

2007-08-28

Infrared spectroscopy maps of some tracks, made by cometary dust from 81P/Wild 2 impacting Stardust aerogel, reveal an interesting distribution of volatile organic material. Out of six examined tracks three show presence of volatile organic components possibly injected into the aerogel during particle impacts. When particle tracks contained excess volatile organic material, they were found to be -CH{sub 2}-rich. Off-normal particle tracks could indicate impacts by lower velocity particles that could have bounced off the Whipple shield, therefore carry off some contamination from it. However, this theory is not supported by data that show excess organic-rich material in normal andmore » off-normal particle tracks. It is clear that the population of cometary particles impacting the Stardust aerogel collectors also include grains that contained little or none of this volatile organic component. This observation is consistent with the highly heterogeneous nature of the collected grains, as seen by a multitude of other analytical techniques. We propose that at least some of the volatile organic material might be of cometary origin based on supporting data shown in this paper. However, we also acknowledge the presence of carbon (primarily as -CH{sub 3}) in the original aerogel, which complicates interpretation of these results.« less

Primary cosmic ray particles with Z greater than 35 /VVH particles/. [Very Very Heavy particle track measurement by balloons

NASA Technical Reports Server (NTRS)

Blanford, G. E., Jr.; Friedlander, M. W.; Hoppe, M.; Klarmann, J.; Walker, R. M.; Wefel, J. P.

1974-01-01

Large areas of nuclear emulsions and plastic detectors were exposed to the primary cosmic radiation during high-altitude balloon flights. From an analysis of 141 particle tracks recorded during a total exposure of 13,000,000 sq m-ster-sec, a charge spectrum of the VVH particles has been derived.

Integrating Geochemical Reactions with a Particle-Tracking Approach to Simulate Nitrogen Transport and Transformation in Aquifers

NASA Astrophysics Data System (ADS)

Cui, Z.; Welty, C.; Maxwell, R. M.

2011-12-01

Lagrangian, particle-tracking models are commonly used to simulate solute advection and dispersion in aquifers. They are computationally efficient and suffer from much less numerical dispersion than grid-based techniques, especially in heterogeneous and advectively-dominated systems. Although particle-tracking models are capable of simulating geochemical reactions, these reactions are often simplified to first-order decay and/or linear, first-order kinetics. Nitrogen transport and transformation in aquifers involves both biodegradation and higher-order geochemical reactions. In order to take advantage of the particle-tracking approach, we have enhanced an existing particle-tracking code SLIM-FAST, to simulate nitrogen transport and transformation in aquifers. The approach we are taking is a hybrid one: the reactive multispecies transport process is operator split into two steps: (1) the physical movement of the particles including the attachment/detachment to solid surfaces, which is modeled by a Lagrangian random-walk algorithm; and (2) multispecies reactions including biodegradation are modeled by coupling multiple Monod equations with other geochemical reactions. The coupled reaction system is solved by an ordinary differential equation solver. In order to solve the coupled system of equations, after step 1, the particles are converted to grid-based concentrations based on the mass and position of the particles, and after step 2 the newly calculated concentration values are mapped back to particles. The enhanced particle-tracking code is capable of simulating subsurface nitrogen transport and transformation in a three-dimensional domain with variably saturated conditions. Potential application of the enhanced code is to simulate subsurface nitrogen loading to the Chesapeake Bay and its tributaries. Implementation details, verification results of the enhanced code with one-dimensional analytical solutions and other existing numerical models will be presented in addition to a discussion of implementation challenges.

Local characterization of hindered Brownian motion by using digital video microscopy and 3D particle tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dettmer, Simon L.; Keyser, Ulrich F.; Pagliara, Stefano

In this article we present methods for measuring hindered Brownian motion in the confinement of complex 3D geometries using digital video microscopy. Here we discuss essential features of automated 3D particle tracking as well as diffusion data analysis. By introducing local mean squared displacement-vs-time curves, we are able to simultaneously measure the spatial dependence of diffusion coefficients, tracking accuracies and drift velocities. Such local measurements allow a more detailed and appropriate description of strongly heterogeneous systems as opposed to global measurements. Finite size effects of the tracking region on measuring mean squared displacements are also discussed. The use of thesemore » methods was crucial for the measurement of the diffusive behavior of spherical polystyrene particles (505 nm diameter) in a microfluidic chip. The particles explored an array of parallel channels with different cross sections as well as the bulk reservoirs. For this experiment we present the measurement of local tracking accuracies in all three axial directions as well as the diffusivity parallel to the channel axis while we observed no significant flow but purely Brownian motion. Finally, the presented algorithm is suitable also for tracking of fluorescently labeled particles and particles driven by an external force, e.g., electrokinetic or dielectrophoretic forces.« less

Development of a real-time internal and external marker tracking system for particle therapy: a phantom study using patient tumor trajectory data.

PubMed

Cho, Junsang; Cheon, Wonjoong; Ahn, Sanghee; Jung, Hyunuk; Sheen, Heesoon; Park, Hee Chul; Han, Youngyih

2017-09-01

Target motion-induced uncertainty in particle therapy is more complicated than that in X-ray therapy, requiring more accurate motion management. Therefore, a hybrid motion-tracking system that can track internal tumor motion and as well as an external surrogate of tumor motion was developed. Recently, many correlation tests between internal and external markers in X-ray therapy have been developed; however, the accuracy of such internal/external marker tracking systems, especially in particle therapy, has not yet been sufficiently tested. In this article, the process of installing an in-house hybrid internal/external motion-tracking system is described and the accuracy level of tracking system was acquired. Our results demonstrated that the developed in-house external/internal combined tracking system has submillimeter accuracy, and can be clinically used as a particle therapy system as well as a simulation system for moving tumor treatment. © The Author 2017. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

Assessment of the pseudo-tracking approach for the calculation of material acceleration and pressure fields from time-resolved PIV: part I. Error propagation

NASA Astrophysics Data System (ADS)

van Gent, P. L.; Schrijer, F. F. J.; van Oudheusden, B. W.

2018-04-01

Pseudo-tracking refers to the construction of imaginary particle paths from PIV velocity fields and the subsequent estimation of the particle (material) acceleration. In view of the variety of existing and possible alternative ways to perform the pseudo-tracking method, it is not straightforward to select a suitable combination of numerical procedures for its implementation. To address this situation, this paper extends the theoretical framework for the approach. The developed theory is verified by applying various implementations of pseudo-tracking to a simulated PIV experiment. The findings of the investigations allow us to formulate the following insights and practical recommendations: (1) the velocity errors along the imaginary particle track are primarily a function of velocity measurement errors and spatial velocity gradients; (2) the particle path may best be calculated with second-order accurate numerical procedures while ensuring that the CFL condition is met; (3) least-square fitting of a first-order polynomial is a suitable method to estimate the material acceleration from the track; and (4) a suitable track length may be selected on the basis of the variation in material acceleration with track length.

Tracking of Ball and Players in Beach Volleyball Videos

PubMed Central

Gomez, Gabriel; Herrera López, Patricia; Link, Daniel; Eskofier, Bjoern

2014-01-01

This paper presents methods for the determination of players' positions and contact time points by tracking the players and the ball in beach volleyball videos. Two player tracking methods are compared, a classical particle filter and a rigid grid integral histogram tracker. Due to mutual occlusion of the players and the camera perspective, results are best for the front players, with 74,6% and 82,6% of correctly tracked frames for the particle method and the integral histogram method, respectively. Results suggest an improved robustness against player confusion between different particle sets when tracking with a rigid grid approach. Faster processing and less player confusions make this method superior to the classical particle filter. Two different ball tracking methods are used that detect ball candidates from movement difference images using a background subtraction algorithm. Ball trajectories are estimated and interpolated from parabolic flight equations. The tracking accuracy of the ball is 54,2% for the trajectory growth method and 42,1% for the Hough line detection method. Tracking results of over 90% from the literature could not be confirmed. Ball contact frames were estimated from parabolic trajectory intersection, resulting in 48,9% of correctly estimated ball contact points. PMID:25426936

A hand tracking algorithm with particle filter and improved GVF snake model

NASA Astrophysics Data System (ADS)

Sun, Yi-qi; Wu, Ai-guo; Dong, Na; Shao, Yi-zhe

2017-07-01

To solve the problem that the accurate information of hand cannot be obtained by particle filter, a hand tracking algorithm based on particle filter combined with skin-color adaptive gradient vector flow (GVF) snake model is proposed. Adaptive GVF and skin color adaptive external guidance force are introduced to the traditional GVF snake model, guiding the curve to quickly converge to the deep concave region of hand contour and obtaining the complex hand contour accurately. This algorithm realizes a real-time correction of the particle filter parameters, avoiding the particle drift phenomenon. Experimental results show that the proposed algorithm can reduce the root mean square error of the hand tracking by 53%, and improve the accuracy of hand tracking in the case of complex and moving background, even with a large range of occlusion.

The effects of delta rays on the number of particle-track traversals per cell in laboratory and space exposures

NASA Technical Reports Server (NTRS)

Cucinotta, F. A.; Nikjoo, H.; Goodhead, D. T.; Wilson, J. W. (Principal Investigator)

1998-01-01

It is a common practice to estimate the number of particle-track traversals per cell or cell nucleus as the product of the ion's linear energy transfer (LET) and cell area. This practice ignores the effects of track width due to the lateral extension of delta rays. We make estimates of the number of particle-track traversals per cell, which includes the effects of delta rays using radial cutoffs in the ionization density about an ion's track of 1 mGy and 1 cGy. Calculations for laboratory and space radiation exposures are discussed, and show that the LET approximation provides a large underestimate of the actual number of particle-track traversals per cell from high-charge and energy (HZE) ions. In light of the current interest in the mechanisms of radiation action, including signal transduction and cytoplasmic damage, these results should be of interest for radiobiology studies with HZE ions.

Detection limit of a VCO based detection chain dedicated to particles recognition and tracking

NASA Astrophysics Data System (ADS)

Coulié, K.; Rahajandraibe, W.; Aziza, H.; Micolau, G.; Vauché, R.

2018-01-01

A particle detection chain based on CMOS-SOI VCO circuit is presented. The solution is used for the recognition and the tracking of a given particle at circuit level. TCAD simulation of the detector has been performed on a 3×3 matrix of diodes based detector for particles recognition and tracking. The current response of the detector has been used for a case study in order to determine the ability of the chain to recognize an alpha particle crossing a 3×3 detection cell. The detection limit of the proposed solution is investigated and discussed in this paper.

Track-structure simulations for charged particles.

PubMed

Dingfelder, Michael

2012-11-01

Monte Carlo track-structure simulations provide a detailed and accurate picture of radiation transport of charged particles through condensed matter of biological interest. Liquid water serves as a surrogate for soft tissue and is used in most Monte Carlo track-structure codes. Basic theories of radiation transport and track-structure simulations are discussed and differences compared to condensed history codes highlighted. Interaction cross sections for electrons, protons, alpha particles, and light and heavy ions are required input data for track-structure simulations. Different calculation methods, including the plane-wave Born approximation, the dielectric theory, and semi-empirical approaches are presented using liquid water as a target. Low-energy electron transport and light ion transport are discussed as areas of special interest.

Reversible assembly of magnetized particles: Application to water-borne pathogen enumeration

NASA Astrophysics Data System (ADS)

Ramadan, Qasem

2009-12-01

Reversible assembly of magnetized particles and cells has been proposed and implemented. The approach is based on magnetized particles or magnetically labeled cell immobilization in an array of individual particle/cell for optical counting. The device has been tested for few types of magnetic particles and one water-borne pathogen: Giardia Lamblia. An individual particle immobilization efficiency of 92% was achieved.

Simulation of zones of contribution to wells at site GM–38, Naval Weapons Industrial Reserve Plant, Bethpage, New York

USGS Publications Warehouse

Misut, Paul

2014-01-01

A three-dimensional groundwater-flow model is coupled with the particle-tracking program MODPATH to delineate zones of contribution to wells pumping from the Magothy aquifer and supplying water to a chlorinated volatile organic compound removal plant at site GM–38, Naval Weapons Industrial Reserve Plant, Bethpage, New York. By use of driller’s logs, a transitional probability approach generated three alternative realizations of heterogeneity within the Magothy aquifer to assess uncertainty in model representation. Finer-grained sediments with low hydraulic conductivity were realized as laterally discontinuous, thickening towards the south, and comprising about 17 percent of the total aquifer volume. Particle-tracking evaluations of a steady state present conditions model with alternative heterogeneity realizations were used to develop zones of contribution of remedial pumping wells. Because of heterogeneity and high rates of advection within the coarse-grained sediments, transport by dispersion and (or) diffusion was assumed to be negligible. Resulting zones of contribution of existing remedial wells are complex shapes, influenced by heterogeneity of each realization and other nearby hydrologic stresses. The use of two particle tracking techniques helped identify zones of contribution to wells. Backtracking techniques and observations of points of intersection of backward-tracked particles at shells of the GM–38 Hot Spot, as defined by surfaces of equal total volatile organic compound concentration, identified the source of water within the GM–38 Hot Spot to simulated wells. Forward-tracking techniques identified the fate of water within the GM–38 Hot Spot, including well capture and discharge to model constant head and drain boundaries. The percentage of backward-tracked particles, started at GM–38 wells that were sourced from within the Hot Spot, varied from 72.0 to 98.2, depending on the Hot Spot delineation used (present steady state model and Magothy aquifer heterogeneity realization A). The percentage of forward-tracked particles that were captured by GM–38 wells varied from 81.1 to 94.6, depending on the Hot Spot delineation used, with the remainder primarily captured by Bethpage Water District Plant 4 production wells (present steady state model and Magothy aquifer heterogeneity realization A). Less than 1 percent of forward-tracked particles ultimately discharge at model constant head and drain boundaries. The differences between forward- and backward-tracked particle percentage ranges are due to some forward-tracked particles not being captured by GM–38 wells, and some backward-tracked particles not intersecting specific regions of the Hot Spot. During 2013, an aquifer test generated detailed time series of well pumping rates and corresponding water-level responses were recorded at numerous locations. These data were used to verify the present conditions steady state model and demonstrate the sensitivity of model results to transient-state changes.

Aerogel Track Morphology: Measurement, Three Dimensional Reconstruction and Particle Location using Confocal Laser Scanning Microscopy

NASA Technical Reports Server (NTRS)

Kearsley, A. T.; Ball, A. D.; Wozniakiewicz, P. A.; Graham, G. A.; Burchell, M. J.; Cole, M. J.; Horz, F.; See, T. H.

2007-01-01

The Stardust spacecraft returned the first undoubted samples of cometary dust, with many grains embedded in the silica aerogel collector . Although many tracks contain one or more large terminal particles of a wide range of mineral compositions , there is also abundant material along the track walls. To help interpret the full particle size, structure and mass, both experimental simulation of impact by shots and numerical modeling of the impact process have been attempted. However, all approaches require accurate and precise measurement of impact track size parameters such as length, width and volume of specific portions. To make such measurements is not easy, especially if extensive aerogel fracturing and discoloration has occurred. In this paper we describe the application and limitations of laser confocal imagery for determination of aerogel track parameters, and for the location of particle remains.

Stardust Interstellar Preliminary Examination IX: High-Speed Interstellar Dust Analog Capture in Stardust Flight-Spare Aerogel

NASA Technical Reports Server (NTRS)

Postberg, F.; Sterken, V.; Achilles, C.; Allen, C.; Bastien, R. K.; Frank, D.; Sandford, S. A.; Zolensky, M. E.; Butterworth, A.; Gainesforth, Z.

2014-01-01

The NASA Stardust mission used silica aerogel slabs to slowly decelerate and capture impinging cosmic dust particles for return to Earth. During this process, impact tracks are generated along the trajectory of the particle into the aerogel. It is believed that the morphology and dimensions of these tracks, together with the state of captured grains at track termini, may be linked to the size, velocity, and density of the impacting cosmic dust grain. Here, we present the results of laboratory hypervelocity impact experiments, during which cosmic dust analog particles (diameters of between 0.2 and 0.4 lm), composed of olivine, orthopyroxene, or an organic polymer, were accelerated onto Stardust flight spare low-density (approximately 0.01 g/cu cm) silica aerogel. The impact velocities (3-21 km/s) were chosen to simulate the range of velocities expected during Stardust's interstellar dust (ISD) collection phases. Track lengths and widths, together with the success of particle capture, are analyzed as functions of impact velocity and particle composition, density, and size. Captured terminal particles from low-density organic projectiles become undetectable at lower velocities than those from similarly sized, denser mineral particles, which are still detectable (although substantially altered by the impact process) at 15 km/s. The survival of these terminal particles, together with the track dimensions obtained during low impact speed capture of small grains in the laboratory, indicates that two of the three best Stardust candidate extraterrestrial grains were actually captured at speeds much lower than predicted. Track length and diameters are, in general, more sensitive to impact velocities than previously expected, which makes tracks of particles with diameters of 0.4 lm and below hard to identify at low capture speeds (<10 km/s). Therefore, although captured intact, the majority of the interstellar dust grains returned to Earth by Stardust remain to be found.

Luminescent sensors for tracking spatial particle distributions in an explosion

NASA Astrophysics Data System (ADS)

Anderson, Benjamin R.; Gunawidjaja, Ray; Diez-y-Riega, Helena; Eilers, Hergen; Svingala, Forrest R.; Daniels, Amber; Lightstone, James M.

2017-01-01

We previously developed and tested thermally sensitive particles that, when seeded into an explosive event, flow with the expanding post-detonation fireball and provide ex-situ measurements of this thermal environment. This current work presents the development and testing of tracking particles that are used in concert with the thermally sensitive particles to encode the initial positions of materials recovered for ex-situ analysis. These tracking sensors consist of fully-crystallized (c) rare-earth-doped yttria particles such as c-Dy:Y2O3, c-Sm:Y2O3, and c-Er,Yb:Y2O3. The temperature sensors consist of mixtures of precursor (p) and fully crystallized materials such as p-Eu:Y2O3/c-Tb:Y2O3 or p-Eu:ZrO2. Three mixtures containing one of the tracking sensors and one of the temperature sensing mixtures are placed at different locations within the chamber. Post-detonation, the tracking particles in the debris are excited by 355 nm light, resulting in different color luminescence, and allowing for potential visual inspection of the particle distribution originating from the different locations. Meanwhile, the temperature is determined from spectral changes of the precursor sensor materials or by comparison of the precursor sensor materials with the Tb:Y2O3 intensity reference.

Correlation of Particle Traversals with Clonogenic Survival Using Cell-Fluorescent Ion Track Hybrid Detector.

PubMed

Dokic, Ivana; Niklas, Martin; Zimmermann, Ferdinand; Mairani, Andrea; Seidel, Philipp; Krunic, Damir; Jäkel, Oliver; Debus, Jürgen; Greilich, Steffen; Abdollahi, Amir

2015-01-01

Development of novel approaches linking the physical characteristics of particles with biological responses are of high relevance for the field of particle therapy. In radiobiology, the clonogenic survival of cells is considered the gold standard assay for the assessment of cellular sensitivity to ionizing radiation. Toward further development of next generation biodosimeters in particle therapy, cell-fluorescent ion track hybrid detector (Cell-FIT-HD) was recently engineered by our group and successfully employed to study physical particle track information in correlation with irradiation-induced DNA damage in cell nuclei. In this work, we investigated the feasibility of Cell-FIT-HD as a tool to study the effects of clinical beams on cellular clonogenic survival. Tumor cells were grown on the fluorescent nuclear track detector as cell culture, mimicking the standard procedures for clonogenic assay. Cell-FIT-HD was used to detect the spatial distribution of particle tracks within colony-initiating cells. The physical data were associated with radiation-induced foci as surrogates for DNA double-strand breaks, the hallmark of radiation-induced cell lethality. Long-term cell fate was monitored to determine the ability of cells to form colonies. We report the first successful detection of particle traversal within colony-initiating cells at subcellular resolution using Cell-FIT-HD.

Single-camera three-dimensional tracking of natural particulate and zooplankton

NASA Astrophysics Data System (ADS)

Troutman, Valerie A.; Dabiri, John O.

2018-07-01

We develop and characterize an image processing algorithm to adapt single-camera defocusing digital particle image velocimetry (DDPIV) for three-dimensional (3D) particle tracking velocimetry (PTV) of natural particulates, such as those present in the ocean. The conventional DDPIV technique is extended to facilitate tracking of non-uniform, non-spherical particles within a volume depth an order of magnitude larger than current single-camera applications (i.e. 10 cm  ×  10 cm  ×  24 cm depth) by a dynamic template matching method. This 2D cross-correlation method does not rely on precise determination of the centroid of the tracked objects. To accommodate the broad range of particle number densities found in natural marine environments, the performance of the measurement technique at higher particle densities has been improved by utilizing the time-history of tracked objects to inform 3D reconstruction. The developed processing algorithms were analyzed using synthetically generated images of flow induced by Hill’s spherical vortex, and the capabilities of the measurement technique were demonstrated empirically through volumetric reconstructions of the 3D trajectories of particles and highly non-spherical, 5 mm zooplankton.

Multiscale spectral nanoscopy

DOEpatents

Yang, Haw; Welsher, Kevin

2016-11-15

A system and method for non-invasively tracking a particle in a sample is disclosed. The system includes a 2-photon or confocal laser scanning microscope (LSM) and a particle-holding device coupled to a stage with X-Y and Z position control. The system also includes a tracking module having a tracking excitation laser, X-Y and Z radiation-gathering components configured to detect deviations of the particle in an X-Y and Z directions. The system also includes a processor coupled to the X-Y and Z radiation gathering components, generate control signals configured to drive the stage X-Y and Z position controls to track the movement of the particle. The system may also include a synchronization module configured to generate LSM pixels stamped with stage position and a processing module configured to generate a 3D image showing the 3D trajectory of a particle using the LSM pixels stamped with stage position.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Talman, Richard M.; Talman, John D.

Proposed methods for measuring the electric dipole moment (EDM) of the proton use an intense, polarized proton beam stored in an all-electric storage ring “trap.” At the “magic” kinetic energy of 232.792 MeV, proton spins are “frozen,” for example always parallel to the instantaneous particle momentum. Energy deviation from the magic value causes in-plane precession of the spin relative to the momentum. Any nonzero EDM value will cause out-of-plane precession—measuring this precession is the basis for the EDM determination. A proposed implementation of this measurement shows that a proton EDM value of 10 –29e–cm or greater will produce a statisticallymore » significant, measurable precession after multiply repeated runs, assuming small beam depolarization during 1000 s runs, with high enough precision to test models of the early universe developed to account for the present day particle/antiparticle population imbalance. This paper describes an accelerator simulation code, eteapot, a new component of the Unified Accelerator Libraries (ual), to be used for long term tracking of particle orbits and spins in electric bend accelerators, in order to simulate EDM storage ring experiments. Though qualitatively much like magnetic rings, the nonconstant particle velocity in electric rings gives them significantly different properties, especially in weak focusing rings. Like the earlier code teapot (for magnetic ring simulation) this code performs exact tracking in an idealized (approximate) lattice rather than the more conventional approach, which is approximate tracking in a more nearly exact lattice. The Bargmann-Michel-Telegdi (BMT) equation describing the evolution of spin vectors through idealized bend elements is also solved exactly—original to this paper. Furthermore the idealization permits the code to be exactly symplectic (with no artificial “symplectification”). Any residual spurious damping or antidamping is sufficiently small to permit reliable tracking for the long times, such as the 1000 s assumed in estimating the achievable EDM precision. This paper documents in detail the theoretical formulation implemented in eteapot. An accompanying paper describes the practical application of the eteapot code in the Universal Accelerator Libraries (ual) environment to “resurrect,” or reverse engineer, the “AGS-analog” all-electric ring built at Brookhaven National Laboratory in 1954. Of the (very few) all-electric rings ever commissioned, the AGS-analog ring is the only relativistic one and is the closest to what is needed for measuring proton (or, even more so, electron) EDM’s. As a result, the companion paper also describes preliminary lattice studies for the planned proton EDM storage rings as well as testing the code for long time orbit and spin tracking.« less

Nanometer-scale anatomy of entire Stardust tracks

NASA Astrophysics Data System (ADS)

Nakamura-Messenger, Keiko; Keller, Lindsay P.; Clemett, Simon J.; Messenger, Scott; Ito, Motoo

2011-07-01

We have developed new sample preparation and analytical techniques tailored for entire aerogel tracks of Wild 2 sample analyses both on "carrot" and "bulbous" tracks. We have successfully ultramicrotomed an entire track along its axis while preserving its original shape. This innovation allowed us to examine the distribution of fragments along the entire track from the entrance hole all the way to the terminal particle. The crystalline silicates we measured have Mg-rich compositions and O isotopic compositions in the range of meteoritic materials, implying that they originated in the inner solar system. The terminal particle of the carrot track is a 16O-rich forsteritic grain that may have formed in a similar environment as Ca-, Al-rich inclusions and amoeboid olivine aggregates in primitive carbonaceous chondrites. The track also contains submicron-sized diamond grains likely formed in the solar system. Complex aromatic hydrocarbons distributed along aerogel tracks and in terminal particles. These organics are likely cometary but affected by shock heating.

UmUTracker: A versatile MATLAB program for automated particle tracking of 2D light microscopy or 3D digital holography data

NASA Astrophysics Data System (ADS)

Zhang, Hanqing; Stangner, Tim; Wiklund, Krister; Rodriguez, Alvaro; Andersson, Magnus

2017-10-01

We present a versatile and fast MATLAB program (UmUTracker) that automatically detects and tracks particles by analyzing video sequences acquired by either light microscopy or digital in-line holographic microscopy. Our program detects the 2D lateral positions of particles with an algorithm based on the isosceles triangle transform, and reconstructs their 3D axial positions by a fast implementation of the Rayleigh-Sommerfeld model using a radial intensity profile. To validate the accuracy and performance of our program, we first track the 2D position of polystyrene particles using bright field and digital holographic microscopy. Second, we determine the 3D particle position by analyzing synthetic and experimentally acquired holograms. Finally, to highlight the full program features, we profile the microfluidic flow in a 100 μm high flow chamber. This result agrees with computational fluid dynamic simulations. On a regular desktop computer UmUTracker can detect, analyze, and track multiple particles at 5 frames per second for a template size of 201 ×201 in a 1024 × 1024 image. To enhance usability and to make it easy to implement new functions we used object-oriented programming. UmUTracker is suitable for studies related to: particle dynamics, cell localization, colloids and microfluidic flow measurement. Program Files doi : http://dx.doi.org/10.17632/fkprs4s6xp.1 Licensing provisions : Creative Commons by 4.0 (CC by 4.0) Programming language : MATLAB Nature of problem: 3D multi-particle tracking is a common technique in physics, chemistry and biology. However, in terms of accuracy, reliable particle tracking is a challenging task since results depend on sample illumination, particle overlap, motion blur and noise from recording sensors. Additionally, the computational performance is also an issue if, for example, a computationally expensive process is executed, such as axial particle position reconstruction from digital holographic microscopy data. Versatile robust tracking programs handling these concerns and providing a powerful post-processing option are significantly limited. Solution method: UmUTracker is a multi-functional tool to extract particle positions from long video sequences acquired with either light microscopy or digital holographic microscopy. The program provides an easy-to-use graphical user interface (GUI) for both tracking and post-processing that does not require any programming skills to analyze data from particle tracking experiments. UmUTracker first conduct automatic 2D particle detection even under noisy conditions using a novel circle detector based on the isosceles triangle sampling technique with a multi-scale strategy. To reduce the computational load for 3D tracking, it uses an efficient implementation of the Rayleigh-Sommerfeld light propagation model. To analyze and visualize the data, an efficient data analysis step, which can for example show 4D flow visualization using 3D trajectories, is included. Additionally, UmUTracker is easy to modify with user-customized modules due to the object-oriented programming style Additional comments: Program obtainable from https://sourceforge.net/projects/umutracker/

Resolving occlusion and segmentation errors in multiple video object tracking

NASA Astrophysics Data System (ADS)

Cheng, Hsu-Yung; Hwang, Jenq-Neng

2009-02-01

In this work, we propose a method to integrate the Kalman filter and adaptive particle sampling for multiple video object tracking. The proposed framework is able to detect occlusion and segmentation error cases and perform adaptive particle sampling for accurate measurement selection. Compared with traditional particle filter based tracking methods, the proposed method generates particles only when necessary. With the concept of adaptive particle sampling, we can avoid degeneracy problem because the sampling position and range are dynamically determined by parameters that are updated by Kalman filters. There is no need to spend time on processing particles with very small weights. The adaptive appearance for the occluded object refers to the prediction results of Kalman filters to determine the region that should be updated and avoids the problem of using inadequate information to update the appearance under occlusion cases. The experimental results have shown that a small number of particles are sufficient to achieve high positioning and scaling accuracy. Also, the employment of adaptive appearance substantially improves the positioning and scaling accuracy on the tracking results.

Surface adsorption and hopping cause probe-size-dependent microrheology of actin networks

NASA Astrophysics Data System (ADS)

He, Jun; Tang, Jay X.

2011-04-01

A network of filaments formed primarily by the abundant cytoskeletal protein actin gives animal cells their shape and elasticity. The rheological properties of reconstituted actin networks have been studied by tracking micron-sized probe beads embedded within the networks. We investigate how microrheology depends on surface properties of probe particles by varying the stickiness of their surface. For this purpose, we chose carboxylate polystyrene (PS) beads, silica beads, bovine serum albumin (BSA) -coated PS beads, and polyethylene glycol (PEG) -grafted PS beads, which show descending stickiness to actin filaments, characterized by confocal imaging and microrheology. Probe size dependence of microrheology is observed for all four types of beads. For the slippery PEG beads, particle-tracking microrheology detects weaker networks using smaller beads, which tend to diffuse through the network by hopping from one confinement “cage” to another. This trend is reversed for the other three types of beads, for which microrheology measures stiffer networks for smaller beads due to physisorption of nearby filaments to the bead surface. We explain the probe size dependence with two simple models. We also evaluate depletion effect near nonadsorption bead surface using quantitative image analysis and discuss the possible impact of depletion on microrheology. Analysis of these effects is necessary in order to accurately define the actin network rheology both in vitro and in vivo.

Angle only tracking with particle flow filters

NASA Astrophysics Data System (ADS)

Daum, Fred; Huang, Jim

2011-09-01

We show the results of numerical experiments for tracking ballistic missiles using only angle measurements. We compare the performance of an extended Kalman filter with a new nonlinear filter using particle flow to compute Bayes' rule. For certain difficult geometries, the particle flow filter is an order of magnitude more accurate than the EKF. Angle only tracking is of interest in several different sensors; for example, passive optics and radars in which range and Doppler data are spoiled by jamming.

Fuzzy inference enhanced information recovery from digital PIV using cross-correlation combined with particle tracking

NASA Technical Reports Server (NTRS)

Wernet, Mark P.

1995-01-01

Particle Image Velocimetry provides a means of measuring the instantaneous 2-component velocity field across a planar region of a seeded flowfield. In this work only two camera, single exposure images are considered where both cameras have the same view of the illumination plane. Two competing techniques which yield unambiguous velocity vector direction information have been widely used for reducing the single exposure, multiple image data: cross-correlation and particle tracking. Correlation techniques yield averaged velocity estimates over subregions of the flow, whereas particle tracking techniques give individual particle velocity estimates. The correlation technique requires identification of the correlation peak on the correlation plane corresponding to the average displacement of particles across the subregion. Noise on the images and particle dropout contribute to spurious peaks on the correlation plane, leading to misidentification of the true correlation peak. The subsequent velocity vector maps contain spurious vectors where the displacement peaks have been improperly identified. Typically these spurious vectors are replaced by a weighted average of the neighboring vectors, thereby decreasing the independence of the measurements. In this work fuzzy logic techniques are used to determine the true correlation displacement peak even when it is not the maximum peak on the correlation plane, hence maximizing the information recovery from the correlation operation, maintaining the number of independent measurements and minimizing the number of spurious velocity vectors. Correlation peaks are correctly identified in both high and low seed density cases. The correlation velocity vector map can then be used as a guide for the particle tracking operation. Again fuzzy logic techniques are used, this time to identify the correct particle image pairings between exposures to determine particle displacements, and thus velocity. The advantage of this technique is the improved spatial resolution which is available from the particle tracking operation. Particle tracking alone may not be possible in the high seed density images typically required for achieving good results from the correlation technique. This two staged approach offers a velocimetric technique capable of measuring particle velocities with high spatial resolution over a broad range of seeding densities.

Iterative Track Fitting Using Cluster Classification in Multi Wire Proportional Chamber

NASA Astrophysics Data System (ADS)

Primor, David; Mikenberg, Giora; Etzion, Erez; Messer, Hagit

2007-10-01

This paper addresses the problem of track fitting of a charged particle in a multi wire proportional chamber (MWPC) using cathode readout strips. When a charged particle crosses a MWPC, a positive charge is induced on a cluster of adjacent strips. In the presence of high radiation background, the cluster charge measurements may be contaminated due to background particles, leading to less accurate hit position estimation. The least squares method for track fitting assumes the same position error distribution for all hits and thus loses its optimal properties on contaminated data. For this reason, a new robust algorithm is proposed. The algorithm first uses the known spatial charge distribution caused by a single charged particle over the strips, and classifies the clusters into ldquocleanrdquo and ldquodirtyrdquo clusters. Then, using the classification results, it performs an iterative weighted least squares fitting procedure, updating its optimal weights each iteration. The performance of the suggested algorithm is compared to other track fitting techniques using a simulation of tracks with radiation background. It is shown that the algorithm improves the track fitting performance significantly. A practical implementation of the algorithm is presented for muon track fitting in the cathode strip chamber (CSC) of the ATLAS experiment.

The new approach for infrared target tracking based on the particle filter algorithm

NASA Astrophysics Data System (ADS)

Sun, Hang; Han, Hong-xia

2011-08-01

Target tracking on the complex background in the infrared image sequence is hot research field. It provides the important basis in some fields such as video monitoring, precision, and video compression human-computer interaction. As a typical algorithms in the target tracking framework based on filtering and data connection, the particle filter with non-parameter estimation characteristic have ability to deal with nonlinear and non-Gaussian problems so it were widely used. There are various forms of density in the particle filter algorithm to make it valid when target occlusion occurred or recover tracking back from failure in track procedure, but in order to capture the change of the state space, it need a certain amount of particles to ensure samples is enough, and this number will increase in accompany with dimension and increase exponentially, this led to the increased amount of calculation is presented. In this paper particle filter algorithm and the Mean shift will be combined. Aiming at deficiencies of the classic mean shift Tracking algorithm easily trapped into local minima and Unable to get global optimal under the complex background. From these two perspectives that "adaptive multiple information fusion" and "with particle filter framework combining", we expand the classic Mean Shift tracking framework .Based on the previous perspective, we proposed an improved Mean Shift infrared target tracking algorithm based on multiple information fusion. In the analysis of the infrared characteristics of target basis, Algorithm firstly extracted target gray and edge character and Proposed to guide the above two characteristics by the moving of the target information thus we can get new sports guide grayscale characteristics and motion guide border feature. Then proposes a new adaptive fusion mechanism, used these two new information adaptive to integrate into the Mean Shift tracking framework. Finally we designed a kind of automatic target model updating strategy to further improve tracking performance. Experimental results show that this algorithm can compensate shortcoming of the particle filter has too much computation, and can effectively overcome the fault that mean shift is easy to fall into local extreme value instead of global maximum value .Last because of the gray and fusion target motion information, this approach also inhibit interference from the background, ultimately improve the stability and the real-time of the target track.

Dynamics and mechanisms of asbestos-fiber aggregate growth in water

NASA Astrophysics Data System (ADS)

Wu, L.; Ortiz, C. P.; Jerolmack, D. J.

2015-12-01

Most colloidal particles including asbestos fibers form aggregates in water, when solution chemistry provides favorable conditions. To date, the growth of colloidal aggregates has been observed in many model systems under optical and scanning electron microscopy; however, all of these studies have used near-spherical particles. The highly elongated nature of asbestos fibers may cause anomalous aggregate growth and morphology, but this has never been examined. Although the exposure pathway of concern for asbestos is through the air, asbestos particles typically reside in soil that is at least partially saturated, and aggregates formed in the aqueous phase may influence the mobility of particles in the environment. Here we study solution-phase aggregation kinetics of asbestos fibers using a liquid-cell by in situ microscopy, over micron to centimeter length scales and from a tenth of a second to hours. We employ an elliptical particle tracking technique to determine particle trajectories and to quantify diffusivity. Experiments reveal that diffusing fibers join by cross linking, but that such linking is sometimes reversible. The resulting aggregates are very sparse and non-compact, with a fractal dimension that is lower than any previously reported value. Their morphology, growth rate and particle size distribution exhibit non-classical behavior that deviates significantly from observations of aggregates composed of near-spherical particles. We also perform experiments using synthetic colloidal particles, and compare these to asbestos in order to separate the controls of particle shape vs. material properties. This direct method for quantitatively observing aggregate growth is a first step toward predicting asbestos fiber aggregate size distributions in the environment. Moreover, many emerging environmental contaminants - such as carbon nanotubes - are elongated colloids, and our work suggests that theories for aggregate growth may need to be modified in order to model these particles.

Tracking Detectors in the STAR Experiment at RHIC

NASA Astrophysics Data System (ADS)

Wieman, Howard

2015-04-01

The STAR experiment at RHIC is designed to measure and identify the thousands of particles produced in 200 Gev/nucleon Au on Au collisions. This talk will focus on the design and construction of two of the main tracking detectors in the experiment, the TPC and the Heavy Flavor Tracker (HFT) pixel detector. The TPC is a solenoidal gas filled detector 4 meters in diameter and 4.2 meters long. It provides precise, continuous tracking and rate of energy loss in the gas (dE/dx) for particles at + - 1 units of pseudo rapidity. The tracking in a half Tesla magnetic field measures momentum and dE/dX provides particle ID. To detect short lived particles tracking close to the point of interaction is required. The HFT pixel detector is a two-layered, high resolution vertex detector located at a few centimeters radius from the collision point. It determines origins of the tracks to a few tens of microns for the purpose of extracting displaced vertices, allowing the identification of D mesons and other short-lived particles. The HFT pixel detector uses detector chips developed by the IPHC group at Strasbourg that are based on standard IC Complementary Metal-Oxide-Semiconductor (CMOS) technology. This is the first time that CMOS pixel chips have been incorporated in a collider application.

Visualisation of γH2AX Foci Caused by Heavy Ion Particle Traversal; Distinction between Core Track versus Non-Track Damage

PubMed Central

Nakajima, Nakako Izumi; Brunton, Holly; Watanabe, Ritsuko; Shrikhande, Amruta; Hirayama, Ryoichi; Matsufuji, Naruhiro; Fujimori, Akira; Murakami, Takeshi; Okayasu, Ryuichi; Jeggo, Penny; Shibata, Atsushi

2013-01-01

Heavy particle irradiation produces complex DNA double strand breaks (DSBs) which can arise from primary ionisation events within the particle trajectory. Additionally, secondary electrons, termed delta-electrons, which have a range of distributions can create low linear energy transfer (LET) damage within but also distant from the track. DNA damage by delta-electrons distant from the track has not previously been carefully characterised. Using imaging with deconvolution, we show that at 8 hours after exposure to Fe (∼200 keV/µm) ions, γH2AX foci forming at DSBs within the particle track are large and encompass multiple smaller and closely localised foci, which we designate as clustered γH2AX foci. These foci are repaired with slow kinetics by DNA non-homologous end-joining (NHEJ) in G1 phase with the magnitude of complexity diminishing with time. These clustered foci (containing 10 or more individual foci) represent a signature of DSBs caused by high LET heavy particle radiation. We also identified simple γH2AX foci distant from the track, which resemble those arising after X-ray exposure, which we attribute to low LET delta-electron induced DSBs. They are rapidly repaired by NHEJ. Clustered γH2AX foci induced by heavy particle radiation cause prolonged checkpoint arrest compared to simple γH2AX foci following X-irradiation. However, mitotic entry was observed when ∼10 clustered foci remain. Thus, cells can progress into mitosis with multiple clusters of DSBs following the traversal of a heavy particle. PMID:23967070

Luminescent Sensors for Tracking Spatial Particle Distribution in an Explosion

NASA Astrophysics Data System (ADS)

Eilers, Hergen; Gunawidjaja, Ray; Diez-Y-Riega, Helena; Svingala, Forrest; Daniels, Amber; Lightstone, James; Washington State University Collaboration; Nswc Iheodtd Collaboration

2015-06-01

We previously developed and tested thermally sensitive particles that, when seeded into an explosive event, flow with the expanding post-detonation fireball and provide ex-situ measurements of this thermal environment. This current work presents the development and testing of tracking particles that are used in concert with the thermally sensitive particles to encode the initial positions of materials recovered for ex-situ analysis. These tracking sensors consist of fully-crystallized (c) rare-earth-doped yttria particles such as c-Dy:Y2O3, c-Sm:Y2O3, and c-Er,Yb:Y2O3. The temperature sensors consist of mixtures of precursor (p) and fully crystallized materials such as p-Eu:Y2O3/c-Tb:Y2O3 orp-Eu:ZrO2/c-Tb:Y2O3. Three mixtures containing one of the tracking sensors and one of the temperature sensing mixtures are placed at different locations within the chamber. Post-detonation, the tracking particles in the debris are excited by 365 nm light, resulting in different color luminescence, and allowing for potential visual inspection of the particle distribution originating from the different locations. Meanwhile, the temperature is determined from spectral changes of the precursor sensor materials or by comparison of the precursor sensor materials with the Tb:Y2O3 intensity reference. Defense Threat Reduction Agency, HDTRA1-10-1-0005.

A Survey of Recent Advances in Particle Filters and Remaining Challenges for Multitarget Tracking

PubMed Central

Wang, Xuedong; Sun, Shudong; Corchado, Juan M.

2017-01-01

We review some advances of the particle filtering (PF) algorithm that have been achieved in the last decade in the context of target tracking, with regard to either a single target or multiple targets in the presence of false or missing data. The first part of our review is on remarkable achievements that have been made for the single-target PF from several aspects including importance proposal, computing efficiency, particle degeneracy/impoverishment and constrained/multi-modal systems. The second part of our review is on analyzing the intractable challenges raised within the general multitarget (multi-sensor) tracking due to random target birth and termination, false alarm, misdetection, measurement-to-track (M2T) uncertainty and track uncertainty. The mainstream multitarget PF approaches consist of two main classes, one based on M2T association approaches and the other not such as the finite set statistics-based PF. In either case, significant challenges remain due to unknown tracking scenarios and integrated tracking management. PMID:29168772

Automated Proton Track Identification in MicroBooNE Using Gradient Boosted Decision Trees

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woodruff, Katherine

MicroBooNE is a liquid argon time projection chamber (LArTPC) neutrino experiment that is currently running in the Booster Neutrino Beam at Fermilab. LArTPC technology allows for high-resolution, three-dimensional representations of neutrino interactions. A wide variety of software tools for automated reconstruction and selection of particle tracks in LArTPCs are actively being developed. Short, isolated proton tracks, the signal for low- momentum-transfer neutral current (NC) elastic events, are easily hidden in a large cosmic background. Detecting these low-energy tracks will allow us to probe interesting regions of the proton's spin structure. An effective method for selecting NC elastic events is tomore » combine a highly efficient track reconstruction algorithm to find all candidate tracks with highly accurate particle identification using a machine learning algorithm. We present our work on particle track classification using gradient tree boosting software (XGBoost) and the performance on simulated neutrino data.« less

Strange Particle Reconstruction by the Missing Mass Method

NASA Astrophysics Data System (ADS)

Kisel, Pavel; Kisel, Ivan; Senger, Peter; Vassiliev, Iouri; Zyzak, Maksym

2018-02-01

The main goal of modern heavy-ion experiments is a comprehensive study of the QCD phase diagram, in a region of Quark-Gluon Plasma (QGP) and possible phase transition to QGP phase. Strange particles produced in the collision are sensitive probes of the created media. Reconstruction of Σ particles together with other strange particles completes the picture of strangeness production. Σ+ and Σ- have all decay modes with at least one neutral daughter, which can not be registered by the CBM detector. For their identification the missing mass method is proposed: a) tracks of the mother (Σ-) and the charged daughter (π-) particles are reconstructed in the tracking system; b) the neutral daughter particle (n) is reconstructed from these tracks; c) a mass constraint is set on the reconstructed neutral daughter; d) the mother particle is constructed of the charged and reconstructed neutral daughter particles and the mass spectrum is obtained, by which the particle can be identified. The method can be applied for other strange particles too. In total 18 particle decays with neutral daughter are now included into physics analysis.

Reverse Transcriptase-Containing Particles Induced in Rous Sarcoma Virus-Transformed Rat Cells by Arginine Deprivation

PubMed Central

Kotler, Moshe; Weinberg, Eynat; Haspel, Osnat; Becker, Yechiel

1972-01-01

Incubation of rat cells transformed by Rous sarcoma virus (RSV) in an arginine-deficient medium resulted in accumulation of particles in the culture medium. Such particles did not appear when the transformed rat cells were incubated in a complete medium nor in the medium of primary rat cells which were incubated either in arginine-deficient or complete media. The particles which were released from the arginine-deprived transformed rat cells resemble C-type particles in their properties. These particles band in sucrose gradients at a density of 1.16 g/ml and contain 35S ribonucleic acid (RNA) molecules and a reverse transcriptase activity. Analysis of the cytoplasm of transformed and primary rat cells, deprived and undeprived of arginine, revealed the presence of reverse transcriptase-containing particles which banded in sucrose gradients at a density of 1.14 g/ml. These particles differed from the particles released into the medium by the arginine-deprived RSV-transformed rat cells. The deoxyribonucleic acid (DNA) molecules synthesized in vitro by the reverse transcriptase present in the particles isolated from the medium of arginine-deprived cells hybridized to RSV RNA, whereas the DNA synthesized by the cell-bound enzyme had no homology to RSV RNA. PMID:4116137

A Protocol for Real-time 3D Single Particle Tracking.

PubMed

Hou, Shangguo; Welsher, Kevin

2018-01-03

Real-time three-dimensional single particle tracking (RT-3D-SPT) has the potential to shed light on fast, 3D processes in cellular systems. Although various RT-3D-SPT methods have been put forward in recent years, tracking high speed 3D diffusing particles at low photon count rates remains a challenge. Moreover, RT-3D-SPT setups are generally complex and difficult to implement, limiting their widespread application to biological problems. This protocol presents a RT-3D-SPT system named 3D Dynamic Photon Localization Tracking (3D-DyPLoT), which can track particles with high diffusive speed (up to 20 µm 2 /s) at low photon count rates (down to 10 kHz). 3D-DyPLoT employs a 2D electro-optic deflector (2D-EOD) and a tunable acoustic gradient (TAG) lens to drive a single focused laser spot dynamically in 3D. Combined with an optimized position estimation algorithm, 3D-DyPLoT can lock onto single particles with high tracking speed and high localization precision. Owing to the single excitation and single detection path layout, 3D-DyPLoT is robust and easy to set up. This protocol discusses how to build 3D-DyPLoT step by step. First, the optical layout is described. Next, the system is calibrated and optimized by raster scanning a 190 nm fluorescent bead with the piezoelectric nanopositioner. Finally, to demonstrate real-time 3D tracking ability, 110 nm fluorescent beads are tracked in water.

Lagrangian Particle Tracking Simulation for Warm-Rain Processes in Quasi-One-Dimensional Domain

NASA Astrophysics Data System (ADS)

Kunishima, Y.; Onishi, R.

2017-12-01

Conventional cloud simulations are based on the Euler method and compute each microphysics process in a stochastic way assuming infinite numbers of particles within each numerical grid. They therefore cannot provide the Lagrangian statistics of individual particles in cloud microphysics (i.e., aerosol particles, cloud particles, and rain drops) nor discuss the statistical fluctuations due to finite number of particles. We here simulate the entire precipitation process of warm-rain, with tracking individual particles. We use the Lagrangian Cloud Simulator (LCS), which is based on the Euler-Lagrangian framework. In that framework, flow motion and scalar transportation are computed with the Euler method, and particle motion with the Lagrangian one. The LCS tracks particle motions and collision events individually with considering the hydrodynamic interaction between approaching particles with a superposition method, that is, it can directly represent the collisional growth of cloud particles. It is essential for trustworthy collision detection to take account of the hydrodynamic interaction. In this study, we newly developed a stochastic model based on the Twomey cloud condensation nuclei (CCN) activation for the Lagrangian tracking simulation and integrated it into the LCS. Coupling with the Euler computation for water vapour and temperature fields, the initiation and condensational growth of water droplets were computed in the Lagrangian way. We applied the integrated LCS for a kinematic simulation of warm-rain processes in a vertically-elongated domain of, at largest, 0.03×0.03×3000 (m3) with horizontal periodicity. Aerosol particles with a realistic number density, 5×107 (m3), were evenly distributed over the domain at the initial state. Prescribed updraft at the early stage initiated development of a precipitating cloud. We have confirmed that the obtained bulk statistics fairly agree with those from a conventional spectral-bin scheme for a vertical column domain. The centre of the discussion will be the Lagrangian statistics which is collected from the individual behaviour of the tracked particles.

Ratchet Transport of Chiral Particles Caused by the Transversal Asymmetry: Current Reversals and Particle Separation

NASA Astrophysics Data System (ADS)

Liu, Jian-li; Lu, Shi-cai; Ai, Bao-quan

2018-06-01

Due to the chirality of active particles, the transversal asymmetry can induce the the longitudinal directed transport. The transport of chiral active particles in a periodic channel is investigated in the presence of two types of the transversal asymmetry, the transverse force and the transverse rigid half-circle obstacles. For all cases, the counterclockwise and clockwise particles move to the opposite directions. For the case of the only transverse force, the chiral active particles can reverse their directions when increasing the transverse force. When the transverse rigid half-circle obstacles are introduced, the transport behavior of particles becomes more complex and multiple current reversals occur. The direction of the transport is determined by the competition between two types of the transversal asymmetry. For a given chirality, by suitably tailoring parameters, particles with different self-propulsion speed can move in different directions and can be separated.

A New Approach to Time-Resolved 3D-PTV

NASA Astrophysics Data System (ADS)

Boomsma, Aaron; Troolin, Dan; Bjorkquist, Dan; TSI Inc Team

2017-11-01

Volumetric three-component velocimetry via particle tracking is a powerful alternative to TomoPIV. It has been thoroughly documented that compared to TomoPIV, particle tracking velocimetry (PTV) methods (whether 2D or 3D) better resolve regions of high velocity gradient, identify fewer ghost particles, and are less computationally demanding, which results in shorter processing times. Recently, 3D-PTV has seen renewed interest in the PIV community with the availability of time-resolved data. Of course, advances in hardware are partly to thank for that availability-higher speed cameras, more effective memory management, and higher speed lasers. But in software, algorithms that utilize time resolved data to improve 3D particle reconstruction and particle tracking are also under development and advancing (e.g. shake-the-box, neighbor tracking reconstruction, etc.). .In the current study, we present a new 3D-PTV method that incorporates time-resolved data. We detail the method, its performance in terms of particle identification and reconstruction error and their relation to varying seeding densities, as well as computational performance.

Color Feature-Based Object Tracking through Particle Swarm Optimization with Improved Inertia Weight

PubMed Central

Guo, Siqiu; Zhang, Tao; Song, Yulong

2018-01-01

This paper presents a particle swarm tracking algorithm with improved inertia weight based on color features. The weighted color histogram is used as the target feature to reduce the contribution of target edge pixels in the target feature, which makes the algorithm insensitive to the target non-rigid deformation, scale variation, and rotation. Meanwhile, the influence of partial obstruction on the description of target features is reduced. The particle swarm optimization algorithm can complete the multi-peak search, which can cope well with the object occlusion tracking problem. This means that the target is located precisely where the similarity function appears multi-peak. When the particle swarm optimization algorithm is applied to the object tracking, the inertia weight adjustment mechanism has some limitations. This paper presents an improved method. The concept of particle maturity is introduced to improve the inertia weight adjustment mechanism, which could adjust the inertia weight in time according to the different states of each particle in each generation. Experimental results show that our algorithm achieves state-of-the-art performance in a wide range of scenarios. PMID:29690610

Color Feature-Based Object Tracking through Particle Swarm Optimization with Improved Inertia Weight.

PubMed

Guo, Siqiu; Zhang, Tao; Song, Yulong; Qian, Feng

2018-04-23

This paper presents a particle swarm tracking algorithm with improved inertia weight based on color features. The weighted color histogram is used as the target feature to reduce the contribution of target edge pixels in the target feature, which makes the algorithm insensitive to the target non-rigid deformation, scale variation, and rotation. Meanwhile, the influence of partial obstruction on the description of target features is reduced. The particle swarm optimization algorithm can complete the multi-peak search, which can cope well with the object occlusion tracking problem. This means that the target is located precisely where the similarity function appears multi-peak. When the particle swarm optimization algorithm is applied to the object tracking, the inertia weight adjustment mechanism has some limitations. This paper presents an improved method. The concept of particle maturity is introduced to improve the inertia weight adjustment mechanism, which could adjust the inertia weight in time according to the different states of each particle in each generation. Experimental results show that our algorithm achieves state-of-the-art performance in a wide range of scenarios.

3D imaging of neutron tracks using confocal microscopy

NASA Astrophysics Data System (ADS)

Gillmore, Gavin; Wertheim, David; Flowers, Alan

2016-04-01

Neutron detection and neutron flux assessment are important aspects in monitoring nuclear energy production. Neutron flux measurements can also provide information on potential biological damage from exposure. In addition to the applications for neutron measurement in nuclear energy, neutron detection has been proposed as a method of enhancing neutrino detectors and cosmic ray flux has also been assessed using ground-level neutron detectors. Solid State Nuclear Track Detectors (or SSNTDs) have been used extensively to examine cosmic rays, long-lived radioactive elements, radon concentrations in buildings and the age of geological samples. Passive SSNTDs consisting of a CR-39 plastic are commonly used to measure radon because they respond to incident charged particles such as alpha particles from radon gas in air. They have a large dynamic range and a linear flux response. We have previously applied confocal microscopy to obtain 3D images of alpha particle tracks in SSNTDs from radon track monitoring (1). As a charged particle traverses through the polymer it creates an ionisation trail along its path. The trail or track is normally enhanced by chemical etching to better expose radiation damage, as the damaged area is more sensitive to the etchant than the bulk material. Particle tracks in CR-39 are usually assessed using 2D optical microscopy. In this study 6 detectors were examined using an Olympus OLS4100 LEXT 3D laser scanning confocal microscope (Olympus Corporation, Japan). The detectors had been etched for 2 hours 50 minutes at 85 °C in 6.25M NaOH. Post etch the plastics had been treated with a 10 minute immersion in a 2% acetic acid stop bath, followed by rinsing in deionised water. The detectors examined had been irradiated with a 2mSv neutron dose from an Am(Be) neutron source (producing roughly 20 tracks per mm2). We were able to successfully acquire 3D images of neutron tracks in the detectors studied. The range of track diameter observed was between 4 and 10 microns. Thus this study suggests that, using confocal microscopy, 3D imaging of neutron tracks in SSNTDs is feasible. (1) Wertheim D, Gillmore G, Brown L, Petford N. A new method of imaging particle tracks in solid state nuclear track detectors. J Microsc. 2010; 237: 1-6.

Image-based Lagrangian Particle Tracking in Bed-load Experiments.

PubMed

Radice, Alessio; Sarkar, Sankar; Ballio, Francesco

2017-07-20

Image analysis has been increasingly used for the measurement of river flows due to its capabilities to furnish detailed quantitative depictions at a relatively low cost. This manuscript describes an application of particle tracking velocimetry (PTV) to a bed-load experiment with lightweight sediment. The key characteristics of the investigated sediment transport conditions were the presence of a covered flow and of a fixed rough bed above which particles were released in limited number at the flume inlet. Under the applied flow conditions, the motion of the individual bed-load particles was intermittent, with alternating movement and stillness terms. The flow pattern was preliminarily characterized by acoustic measurements of vertical profiles of the stream-wise velocity. During process visualization, a large field of view was obtained using two action-cameras placed at different locations along the flume. The experimental protocol is described in terms of channel calibration, experiment realization, image pre-processing, automatic particle tracking, and post-processing of particle track data from the two cameras. The presented proof-of-concept results include probability distributions of the particle hop length and duration. The achievements of this work are compared to those of existing literature to demonstrate the validity of the protocol.

Computer program TRACK_TEST for calculating parameters and plotting profiles for etch pits in nuclear track materials

NASA Astrophysics Data System (ADS)

Nikezic, D.; Yu, K. N.

2006-01-01

A computer program called TRACK_TEST for calculating parameters (lengths of the major and minor axes) and plotting profiles in nuclear track materials resulted from light-ion irradiation and subsequent chemical etching is described. The programming steps are outlined, including calculations of alpha-particle ranges, determination of the distance along the particle trajectory penetrated by the chemical etchant, calculations of track coordinates, determination of the lengths of the major and minor axes and determination of the contour of the track opening. Descriptions of the program are given, including the built-in V functions for the two commonly employed nuclear track materials commercially known as LR 115 (cellulose nitrate) and CR-39 (poly allyl diglycol carbonate) irradiated by alpha particles. Program summaryTitle of the program:TRACK_TEST Catalogue identifier:ADWT Program obtainable from:CPC Program Library, Queen's University of Belfast, N. Ireland Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWT Computer:Pentium PC Operating systems:Windows 95+ Programming language:Fortran 90 Memory required to execute with typical data:256 MB No. of lines in distributed program, including test data, etc.: 2739 No. of bytes in distributed program, including test data, etc.:204 526 Distribution format:tar.gz External subprograms used:The entire code must be linked with the MSFLIB library Nature of problem: Fast heavy charged particles (like alpha particles and other light ions etc.) create latent tracks in some dielectric materials. After chemical etching in aqueous NaOH or KOH solutions, these tracks become visible under an optical microscope. The growth of a track is based on the simultaneous actions of the etchant on undamaged regions (with the bulk etch rate V) and along the particle track (with the track etch rate V). Growth of the track is described satisfactorily by these two parameters ( V and V). Several models have been presented in the past describing the track development, one of which is the model of Nikezic and Yu (2003) [D. Nikezic, K.N. Yu, Three-dimensional analytical determination of the track parameters. Over-etched tracks, Radiat. Meas. 37 (2003) 39-45] used in the present program. The present computer program has been written to calculate coordinates of points on the track wall and to determine other relevant track parameters. Solution method:Coordinates of points on the track wall assuming normal incidence were calculated by using the method as described by Fromm et al. (1988) [M. Fromm, A. Chambaudet, F. Membrey, Data bank for alpha particle tracks in CR39 with energies ranging from 0.5 to 5 MeV recording for various incident angles, Nucl. Tracks Radiat. Meas. 15 (1988) 115-118]. The track is then rotated through the incident angle in order to obtain the coordinates of the oblique track [D. Nikezic, K.N. Yu, Three-dimensional analytical determination of the track parameters. Over-etched tracks, Radiat. Meas. 37 (2003) 39-45; D. Nikezic, Three dimensional analytical determination of the track parameters, Radiat. Meas. 32 (2000) 277-282]. In this way, the track profile in two dimensions (2D) was obtained. In the next step, points in the track wall profile are rotated around the particle trajectory. In this way, circles that outline the track in three dimensions (3D) are obtained. The intersection between the post-etching surface of the detector and the 3D track is the track opening (or the track contour). Coordinates of the track 2D and 3D profiles and the track opening are saved in separate output data files. Restrictions: The program cannot calculate track parameters for the incident angle of exactly 90°. The alpha-particle energy should be smaller than 10 MeV. Furthermore, the program cannot perform calculations for tracks in some extreme cases, such as for very low incident energies or very small incident angles. Additional comments: This is a freeware, but publications arising from using this program should cite the present paper and the paper describing the track growth model [D. Nikezic, K.N. Yu, Three-dimensional analytical determination of the track parameters. Over-etched tracks, Radiat. Meas. 37 (2003) 39-45]. Moreover, the references for the V functions used should also be cited. For the CR-39 detector: Function (1): S.A. Durrani, R.K. Bull, Solid State Nuclear Track Detection. Principles, Methods and Applications, Pergamon Press, 1987. Function (2): C. Brun, M. Fromm, M. Jouffroy, P. Meyer, J.E. Groetz, F. Abel, A. Chambaudet, B. Dorschel, D. Hermsdorf, R. Bretschneider, K. Kadner, H. Kuhne, Intercomparative study of the detection characteristics of the CR-39 SSNTD for light ions: Present status of the Besancon-Dresden approaches, Radiat. Meas. 31 (1999) 89-98. Function (3): K.N. Yu, F.M.F. Ng, D. Nikezic, Measuring depths of sub-micron tracks in a CR-39 detector from replicas using atomic force microscopy, Radiat. Meas. 40 (2005) 380-383. For the LR 115 detector: Function (1): S.A. Durrani, P.F. Green, The effect of etching conditions on the response of LR 115, Nucl. Tracks 8 (1984) 21-24. Function (2): C.W.Y. Yip, D. Nikezic, J.P.Y Ho, K.N. Yu, Chemical etching characteristics for cellulose nitrate, Mat. Chem. Phys. 95 (2005) 307-312. Running time: Order of several minutes, dependent on input parameters and the resolution requested by the user.

Simulation of radiation effects on three-dimensional computer optical memories

NASA Technical Reports Server (NTRS)

Moscovitch, M.; Emfietzoglou, D.

1997-01-01

A model was developed to simulate the effects of heavy charged-particle (HCP) radiation on the information stored in three-dimensional computer optical memories. The model is based on (i) the HCP track radial dose distribution, (ii) the spatial and temporal distribution of temperature in the track, (iii) the matrix-specific radiation-induced changes that will affect the response, and (iv) the kinetics of transition of photochromic molecules from the colored to the colorless isomeric form (bit flip). It is shown that information stored in a volume of several nanometers radius around the particle's track axis may be lost. The magnitude of the effect is dependent on the particle's track structure.

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice.

PubMed

Martel, Catherine; Li, Wenjun; Fulp, Brian; Platt, Andrew M; Gautier, Emmanuel L; Westerterp, Marit; Bittman, Robert; Tall, Alan R; Chen, Shu-Hsia; Thomas, Michael J; Kreisel, Daniel; Swartz, Melody A; Sorci-Thomas, Mary G; Randolph, Gwendalyn J

2013-04-01

Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma. We first used 2 models of disrupted lymphatic drainage from skin--1 surgical and the other genetic--to quantitatively track RCT following injection of [3H]-cholesterol-loaded macrophages upstream of blocked or absent lymphatic vessels. Macrophage RCT was markedly impaired in both models, even at sites with a leaky vasculature. Inhibited RCT was downstream of cholesterol efflux from macrophages, since macrophage efflux of a fluorescent cholesterol analog (BODIPY-cholesterol) was not altered by impaired lymphatic drainage. We next addressed whether RCT was mediated by lymphatic vessels from the aortic wall by loading the aortae of donor atherosclerotic Apoe-deficient mice with [2H]6-labeled cholesterol and surgically transplanting these aortae into recipient Apoe-deficient mice that were treated with anti-VEGFR3 antibody to block lymphatic regrowth or with control antibody to allow such regrowth. [2H]-Cholesterol was retained in aortae of anti-VEGFR3-treated mice. Thus, the lymphatic vessel route is critical for RCT from multiple tissues, including the aortic wall. These results suggest that supporting lymphatic transport function may facilitate cholesterol clearance in therapies aimed at reversing atherosclerosis.

High Z particle Apollo astronaut dosimetry with plastics

NASA Technical Reports Server (NTRS)

Benton, E. V.; Henke, R. P.

1972-01-01

On Apollo missions, the individual astronauts' high Z particle exposure is measured by means of Lexan polycarbonate plastic. These layers form one component of the passive dosimetry packets worn in the constant wear garment. They serve as threshold type, high Z, charged particle track detectors, recording only the very highly ionizing particles. The detectors yield information on the particles' charge, energy, and direction of travel. This data, in turn, is used to obtain the track fluence, the stopping particle density as an integral Z distribution, and the particles' integral LET spectrum. Some of the data gathered on Apollo missions 8-13 is presented.

Detection and tracking of a moving target using SAR images with the particle filter-based track-before-detect algorithm.

PubMed

Gao, Han; Li, Jingwen

2014-06-19

A novel approach to detecting and tracking a moving target using synthetic aperture radar (SAR) images is proposed in this paper. Achieved with the particle filter (PF) based track-before-detect (TBD) algorithm, the approach is capable of detecting and tracking the low signal-to-noise ratio (SNR) moving target with SAR systems, which the traditional track-after-detect (TAD) approach is inadequate for. By incorporating the signal model of the SAR moving target into the algorithm, the ambiguity in target azimuth position and radial velocity is resolved while tracking, which leads directly to the true estimation. With the sub-area substituted for the whole area to calculate the likelihood ratio and a pertinent choice of the number of particles, the computational efficiency is improved with little loss in the detection and tracking performance. The feasibility of the approach is validated and the performance is evaluated with Monte Carlo trials. It is demonstrated that the proposed approach is capable to detect and track a moving target with SNR as low as 7 dB, and outperforms the traditional TAD approach when the SNR is below 14 dB.

Detection and Tracking of a Moving Target Using SAR Images with the Particle Filter-Based Track-Before-Detect Algorithm

PubMed Central

Gao, Han; Li, Jingwen

2014-01-01

A novel approach to detecting and tracking a moving target using synthetic aperture radar (SAR) images is proposed in this paper. Achieved with the particle filter (PF) based track-before-detect (TBD) algorithm, the approach is capable of detecting and tracking the low signal-to-noise ratio (SNR) moving target with SAR systems, which the traditional track-after-detect (TAD) approach is inadequate for. By incorporating the signal model of the SAR moving target into the algorithm, the ambiguity in target azimuth position and radial velocity is resolved while tracking, which leads directly to the true estimation. With the sub-area substituted for the whole area to calculate the likelihood ratio and a pertinent choice of the number of particles, the computational efficiency is improved with little loss in the detection and tracking performance. The feasibility of the approach is validated and the performance is evaluated with Monte Carlo trials. It is demonstrated that the proposed approach is capable to detect and track a moving target with SNR as low as 7 dB, and outperforms the traditional TAD approach when the SNR is below 14 dB. PMID:24949640

Flow convergence caused by a salinity minimum in a tidal channel

USGS Publications Warehouse

Warner, John C.; Schoellhamer, David H.; Burau, Jon R.; Schladow, S. Geoffrey

2006-01-01

Residence times of dissolved substances and sedimentation rates in tidal channels are affected by residual (tidally averaged) circulation patterns. One influence on these circulation patterns is the longitudinal density gradient. In most estuaries the longitudinal density gradient typically maintains a constant direction. However, a junction of tidal channels can create a local reversal (change in sign) of the density gradient. This can occur due to a difference in the phase of tidal currents in each channel. In San Francisco Bay, the phasing of the currents at the junction of Mare Island Strait and Carquinez Strait produces a local salinity minimum in Mare Island Strait. At the location of a local salinity minimum the longitudinal density gradient reverses direction. This paper presents four numerical models that were used to investigate the circulation caused by the salinity minimum: (1) A simple one-dimensional (1D) finite difference model demonstrates that a local salinity minimum is advected into Mare Island Strait from the junction with Carquinez Strait during flood tide. (2) A three-dimensional (3D) hydrodynamic finite element model is used to compute the tidally averaged circulation in a channel that contains a salinity minimum (a change in the sign of the longitudinal density gradient) and compares that to a channel that contains a longitudinal density gradient in a constant direction. The tidally averaged circulation produced by the salinity minimum is characterized by converging flow at the bed and diverging flow at the surface, whereas the circulation produced by the constant direction gradient is characterized by converging flow at the bed and downstream surface currents. These velocity fields are used to drive both a particle tracking and a sediment transport model. (3) A particle tracking model demonstrates a 30 percent increase in the residence time of neutrally buoyant particles transported through the salinity minimum, as compared to transport through a constant direction density gradient. (4) A sediment transport model demonstrates increased deposition at the near-bed null point of the salinity minimum, as compared to the constant direction gradient null point. These results are corroborated by historically noted large sedimentation rates and a local maximum of selenium accumulation in clams at the null point in Mare Island Strait.

Solid State Nuclear Track Detectors--I: Track Characteristics and Formation Mechanisms.

ERIC Educational Resources Information Center

Lal, Nand

1991-01-01

Heavily ionizing charged particles produce radiation damage tracks in a wide variety of insulating materials. The experimental properties of these tracks and track recorders are described. The mechanisms by which the tracks are produced are discussed. (Author/KR)

Optical Trap Loading of Dielectric Microparticles In Air.

PubMed

Park, Haesung; LeBrun, Thomas W

2017-02-05

We demonstrate a method to trap a selected dielectric microparticle in air using radiation pressure from a single-beam gradient optical trap. Randomly scattered dielectric microparticles adhered to a glass substrate are momentarily detached using ultrasonic vibrations generated by a piezoelectric transducer (PZT). Then, the optical beam focused on a selected particle lifts it up to the optical trap while the vibrationally excited microparticles fall back to the substrate. A particle may be trapped at the nominal focus of the trapping beam or at a position above the focus (referred to here as the levitation position) where gravity provides the restoring force. After the measurement, the trapped particle can be placed at a desired position on the substrate in a controlled manner. In this protocol, an experimental procedure for selective optical trap loading in air is outlined. First, the experimental setup is briefly introduced. Second, the design and fabrication of a PZT holder and a sample enclosure are illustrated in detail. The optical trap loading of a selected microparticle is then demonstrated with step-by-step instructions including sample preparation, launching into the trap, and use of electrostatic force to excite particle motion in the trap and measure charge. Finally, we present recorded particle trajectories of Brownian and ballistic motions of a trapped microparticle in air. These trajectories can be used to measure stiffness or to verify optical alignment through time domain and frequency domain analysis. Selective trap loading enables optical tweezers to track a particle and its changes over repeated trap loadings in a reversible manner, thereby enabling studies of particle-surface interaction.

Sandia Simple Particle Tracking (Sandia SPT) v. 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anthony, Stephen M.

2015-06-15

Sandia SPT is designed as software to accompany a book chapter being published a methods chapter which provides an introduction on how to label and track individual proteins. The Sandia Simple Particle Tracking code uses techniques common to the image processing community, where its value is that it facilitates implementing the methods described in the book chapter by providing the necessary open-source code. The code performs single particle spot detection (or segmentation and localization) followed by tracking (or connecting the detected particles into trajectories). The book chapter, which along with the headers in each file, constitutes the documentation for themore » code is: Anthony, S.M.; Carroll-Portillo, A.; Timlon, J.A., Dynamics and Interactions of Individual Proteins in the Membrane of Living Cells. In Anup K. Singh (Ed.) Single Cell Protein Analysis Methods in Molecular Biology. Springer« less

Investigation on microfluidic particles manipulation by holographic 3D tracking strategies

NASA Astrophysics Data System (ADS)

Cacace, Teresa; Paturzo, Melania; Memmolo, Pasquale; Vassalli, Massimo; Fraldi, Massimiliano; Mensitieri, Giuseppe; Ferraro, Pietro

2017-06-01

We demonstrate a 3D holographic tracking method to investigate particles motion in a microfluidic channel while unperturbed while inducing their migration through microfluidic manipulation. Digital holography (DH) in microscopy is a full-field, label-free imaging technique able to provide quantitative phase-contrast. The employed 3D tracking method is articulated in steps. First, the displacements along the optical axis are assessed by numerical refocusing criteria. In particular, an automatic refocusing method to recover the particles axial position is implemented employing a contrast-based refocusing criterion. Then, the transverse position of the in-focus object is evaluated through quantitative phase map segmentation methods and centroid-based 2D tracking strategy. The introduction of DH is thus suggested as a powerful approach for control of particles and biological samples manipulation, as well as a possible aid to precise design and implementation of advanced lab-on-chip microfluidic devices.

New color-based tracking algorithm for joints of the upper extremities

NASA Astrophysics Data System (ADS)

Wu, Xiangping; Chow, Daniel H. K.; Zheng, Xiaoxiang

2007-11-01

To track the joints of the upper limb of stroke sufferers for rehabilitation assessment, a new tracking algorithm which utilizes a developed color-based particle filter and a novel strategy for handling occlusions is proposed in this paper. Objects are represented by their color histogram models and particle filter is introduced to track the objects within a probability framework. Kalman filter, as a local optimizer, is integrated into the sampling stage of the particle filter that steers samples to a region with high likelihood and therefore fewer samples is required. A color clustering method and anatomic constraints are used in dealing with occlusion problem. Compared with the general basic particle filtering method, the experimental results show that the new algorithm has reduced the number of samples and hence the computational consumption, and has achieved better abilities of handling complete occlusion over a few frames.

Software manual for operating particle displacement tracking data acquisition and reduction system

NASA Technical Reports Server (NTRS)

Wernet, Mark P.

1991-01-01

The software manual is presented. The necessary steps required to record, analyze, and reduce Particle Image Velocimetry (PIV) data using the Particle Displacement Tracking (PDT) technique are described. The new PDT system is an all electronic technique employing a CCD video camera and a large memory buffer frame-grabber board to record low velocity (less than or equal to 20 cm/s) flows. Using a simple encoding scheme, a time sequence of single exposure images are time coded into a single image and then processed to track particle displacements and determine 2-D velocity vectors. All the PDT data acquisition, analysis, and data reduction software is written to run on an 80386 PC.

A particle filter for multi-target tracking in track before detect context

NASA Astrophysics Data System (ADS)

Amrouche, Naima; Khenchaf, Ali; Berkani, Daoud

2016-10-01

The track-before-detect (TBD) approach can be used to track a single target in a highly noisy radar scene. This is because it makes use of unthresholded observations and incorporates a binary target existence variable into its target state estimation process when implemented as a particle filter (PF). This paper proposes the recursive PF-TBD approach to detect multiple targets in low-signal-to noise ratios (SNR). The algorithm's successful performance is demonstrated using a simulated two target example.

Scintillator-fiber charged-particle track-imaging detector

NASA Technical Reports Server (NTRS)

Binns, W. R.; Israel, M. H.; Klarmann, J.

1983-01-01

A scintillator-fiber charged-particle track-imaging detector has been developed using a bundle of square cross-section plastic scintillator fiber optics, proximity focused onto an image intensified Charge Injection Device (CID) camera. Detector to beams of 15 MeV protons and relativistic Neon, Manganese, and Gold nuclei have been exposed and images of their tracks are obtained. This paper presents details of the detector technique, properties of the tracks obtained, and range measurements of 15 MeV protons stopping in the fiber bundle.

Novel branching particle method for tracking

NASA Astrophysics Data System (ADS)

Ballantyne, David J.; Chan, Hubert Y.; Kouritzin, Michael A.

2000-07-01

Particle approximations are used to track a maneuvering signal given only a noisy, corrupted sequence of observations, as are encountered in target tracking and surveillance. The signal exhibits nonlinearities that preclude the optimal use of a Kalman filter. It obeys a stochastic differential equation (SDE) in a seven-dimensional state space, one dimension of which is a discrete maneuver type. The maneuver type switches as a Markov chain and each maneuver identifies a unique SDE for the propagation of the remaining six state parameters. Observations are constructed at discrete time intervals by projecting a polygon corresponding to the target state onto two dimensions and incorporating the noise. A new branching particle filter is introduced and compared with two existing particle filters. The filters simulate a large number of independent particles, each of which moves with the stochastic law of the target. Particles are weighted, redistributed, or branched, depending on the method of filtering, based on their accordance with the current observation from the sequence. Each filter provides an approximated probability distribution of the target state given all back observations. All three particle filters converge to the exact conditional distribution as the number of particles goes to infinity, but differ in how well they perform with a finite number of particles. Using the exactly known ground truth, the root-mean-squared (RMS) errors in target position of the estimated distributions from the three filters are compared. The relative tracking power of the filters is quantified for this target at varying sizes, particle counts, and levels of observation noise.

Precision Control and Maneuvering of the Phoenix Autonomous Underwater Vehicle for Entering a Recovery Tube

DTIC Science & Technology

1996-09-01

T1wo such modes have buen iinrylvni teted: a full target-track mode0 and a target- edge-track mode. Whun using thc full target-track mode the sonai ...direction is reversed. Rather than tracking across the target all the way to the opposing edge, however, the sonai is scanned only until three returns

The relationships between high latitude convection reversals and the energetic particle morphology observed by the Atmosphere Explorer

NASA Technical Reports Server (NTRS)

Heelis, R. A.; Winningham, J. D.; Hanson, W. B.; Burch, J. L.

1980-01-01

Simultaneous measurements of the auroral zone particle precipitation and the ion convection velocity by Atmosphere Explorer show a consistent difference between the location of the poleward boundary of the auroral particle precipitation and the ion convection reversal. The difference of about 1.5 degrees of invariant latitude is such that some part of the antisunward convection lies wholly within the auroral particle precipitation region. The nature of the convection reversals within the precipitation region suggests that in this region the convection electric field is generated on closed field lines that connect in the magnetosphere to the low latitude boundary layer.

Fuzzy Logic Particle Tracking

NASA Technical Reports Server (NTRS)

2005-01-01

A new all-electronic Particle Image Velocimetry technique that can efficiently map high speed gas flows has been developed in-house at the NASA Lewis Research Center. Particle Image Velocimetry is an optical technique for measuring the instantaneous two component velocity field across a planar region of a seeded flow field. A pulsed laser light sheet is used to illuminate the seed particles entrained in the flow field at two instances in time. One or more charged coupled device (CCD) cameras can be used to record the instantaneous positions of particles. Using the time between light sheet pulses and determining either the individual particle displacements or the average displacement of particles over a small subregion of the recorded image enables the calculation of the fluid velocity. Fuzzy logic minimizes the required operator intervention in identifying particles and computing velocity. Using two cameras that have the same view of the illumination plane yields two single exposure image frames. Two competing techniques that yield unambiguous velocity vector direction information have been widely used for reducing the single-exposure, multiple image frame data: (1) cross-correlation and (2) particle tracking. Correlation techniques yield averaged velocity estimates over subregions of the flow, whereas particle tracking techniques give individual particle velocity estimates. For the correlation technique, the correlation peak corresponding to the average displacement of particles across the subregion must be identified. Noise on the images and particle dropout result in misidentification of the true correlation peak. The subsequent velocity vector maps contain spurious vectors where the displacement peaks have been improperly identified. Typically these spurious vectors are replaced by a weighted average of the neighboring vectors, thereby decreasing the independence of the measurements. In this work, fuzzy logic techniques are used to determine the true correlation displacement peak even when it is not the maximum peak, hence maximizing the information recovery from the correlation operation, maintaining the number of independent measurements, and minimizing the number of spurious velocity vectors. Correlation peaks are correctly identified in both high and low seed density cases. The correlation velocity vector map can then be used as a guide for the particle-tracking operation. Again fuzzy logic techniques are used, this time to identify the correct particle image pairings between exposures to determine particle displacements, and thus the velocity. Combining these two techniques makes use of the higher spatial resolution available from the particle tracking. Particle tracking alone may not be possible in the high seed density images typically required for achieving good results from the correlation technique. This two-staged velocimetric technique can measure particle velocities with high spatial resolution over a broad range of seeding densities.

Quantitative nanoparticle tracking: applications to nanomedicine.

PubMed

Huang, Feiran; Dempsey, Christopher; Chona, Daniela; Suh, Junghae

2011-06-01

Particle tracking is an invaluable technique to extract quantitative and qualitative information regarding the transport of nanomaterials through complex biological environments. This technique can be used to probe the dynamic behavior of nanoparticles as they interact with and navigate through intra- and extra-cellular barriers. In this article, we focus on the recent developments in the application of particle-tracking technology to nanomedicine, including the study of synthetic and virus-based materials designed for gene and drug delivery. Specifically, we cover research where mean square displacements of nanomaterial transport were explicitly determined in order to quantitatively assess the transport of nanoparticles through biological environments. Particle-tracking experiments can provide important insights that may help guide the design of more intelligent and effective diagnostic and therapeutic nanoparticles.

Particle Detectors

NASA Astrophysics Data System (ADS)

Grupen, Claus; Shwartz, Boris

2011-09-01

Preface to the first edition; Preface to the second edition; Introduction; 1. Interactions of particles and radiation with matter; 2. Characteristic properties of detectors; 3. Units of radiation measurements and radiation sources; 4. Accelerators; 5. Main physical phenomena used for particle detection and basic counter types; 6. Historical track detectors; 7. Track detectors; 8. Calorimetry; 9. Particle identification; 10. Neutrino detectors; 11. Momentum measurement and muon detection; 12. Ageing and radiation effects; 13. Example of a general-purpose detector: Belle; 14. Electronics; 15. Data analysis; 16. Applications of particle detectors outside particle physics; 17. Glossary; 18. Solutions; 19. Resumé; Appendixes; Index.

User guide for MODPATH version 6 - A particle-tracking model for MODFLOW

USGS Publications Warehouse

Pollock, David W.

2012-01-01

MODPATH is a particle-tracking post-processing model that computes three-dimensional flow paths using output from groundwater flow simulations based on MODFLOW, the U.S. Geological Survey (USGS) finite-difference groundwater flow model. This report documents MODPATH version 6. Previous versions were documented in USGS Open-File Reports 89-381 and 94-464. The program uses a semianalytical particle-tracking scheme that allows an analytical expression of a particle's flow path to be obtained within each finite-difference grid cell. A particle's path is computed by tracking the particle from one cell to the next until it reaches a boundary, an internal sink/source, or satisfies another termination criterion. Data input to MODPATH consists of a combination of MODFLOW input data files, MODFLOW head and flow output files, and other input files specific to MODPATH. Output from MODPATH consists of several output files, including a number of particle coordinate output files intended to serve as input data for other programs that process, analyze, and display the results in various ways. MODPATH is written in FORTRAN and can be compiled by any FORTRAN compiler that fully supports FORTRAN-2003 or by most commercially available FORTRAN-95 compilers that support the major FORTRAN-2003 language extensions.

A novel method to study single-particle dynamics by the resistive pulse technique

NASA Astrophysics Data System (ADS)

Berge, L. I.; Feder, J.; Jøssang, T.

1989-08-01

We have developed a new method, a pressure-reversal technique, which extends the uses of the resistive pulse (Coulter counter) technique to single-particle dynamics. The resistive pulse technique measures the increase in resistance when particles suspended in an electrolyte are transported through a current-carrying aperture. By the new method, the pressure is reversed when a particle exits the pore. A trigger signal, derived from the particle pulses, is used to activate two miniature solenoid valves which serve as pressure switches. In this way, the particle reenters the pore. A single particle flowing back and forth may be studied over a long period of time. The time the particle spends outside the pore between reversals is variable from a few milliseconds to several seconds. We have so far used pore diameters in the range of 3-30 μm. The new technique enables us to study single-particle dissolution and single-particle flow dynamics. The experimental arrangement and the details of the new method are described together with some illustrative measurements.

AUTOMATIC COUNTER

DOEpatents

Robinson, H.P.

1960-06-01

An automatic counter of alpha particle tracks recorded by a sensitive emulsion of a photographic plate is described. The counter includes a source of mcdulated dark-field illumination for developing light flashes from the recorded particle tracks as the photographic plate is automatically scanned in narrow strips. Photoelectric means convert the light flashes to proportional current pulses for application to an electronic counting circuit. Photoelectric means are further provided for developing a phase reference signal from the photographic plate in such a manner that signals arising from particle tracks not parallel to the edge of the plate are out of phase with the reference signal. The counting circuit includes provision for rejecting the out-of-phase signals resulting from unoriented tracks as well as signals resulting from spurious marks on the plate such as scratches, dust or grain clumpings, etc. The output of the circuit is hence indicative only of the tracks that would be counted by a human operator.

Solar Flare Track Exposure Ages in Regolith Particles: A Calibration for Transmission Electron Microscope Measurements

NASA Technical Reports Server (NTRS)

Berger, Eve L.; Keller, Lindsay P.

2015-01-01

Mineral grains in lunar and asteroidal regolith samples provide a unique record of their interaction with the space environment. Space weathering effects result from multiple processes including: exposure to the solar wind, which results in ion damage and implantation effects that are preserved in the rims of grains (typically the outermost 100 nm); cosmic ray and solar flare activity, which result in track formation; and impact processes that result in the accumulation of vapor-deposited elements, impact melts and adhering grains on particle surfaces. Determining the rate at which these effects accumulate in the grains during their space exposure is critical to studies of the surface evolution of airless bodies. Solar flare energetic particles (mainly Fe-group nuclei) have a penetration depth of a few millimeters and leave a trail of ionization damage in insulating materials that is readily observable by transmission electron microscope (TEM) imaging. The density of solar flare particle tracks is used to infer the length of time an object was at or near the regolith surface (i.e., its exposure age). Track measurements by TEM methods are routine, yet track production rate calibrations have only been determined using chemical etching techniques [e.g., 1, and references therein]. We used focused ion beam-scanning electron microscope (FIB-SEM) sample preparation techniques combined with TEM imaging to determine the track density/exposure age relations for lunar rock 64455. The 64455 sample was used earlier by [2] to determine a track production rate by chemical etching of tracks in anorthite. Here, we show that combined FIB/TEM techniques provide a more accurate determination of a track production rate and also allow us to extend the calibration to solar flare tracks in olivine.

Non-invasive studies of multiphase flow in process equipment. Positron emission particle tracking technique

NASA Astrophysics Data System (ADS)

Balakin, B. V.; Adamsen, T. C. H.; Chang, Y.-F.; Kosinski, P.; Hoffmann, A. C.

2017-01-01

Positron emission particle tracking (PEPT) is a novel experimental technique for non-invasive inspection of industrial fluid/particle flows. The method is based on the dynamic positioning of a positron-emitting, flowing object (particle) performed through the sensing of annihilation events and subsequent numerical treatment to determine the particle position. The present paper shows an integrated overview of PEPT studies which were carried out using a new PET scanner in the Bergen University Hospital to study multiphase flows in different geometric configurations.

New Mexico Play Fairway Analysis: Particle Tracking ArcGIS Map Packages

DOE Data Explorer

Jeff Pepin

2015-11-15

These are map packages used to visualize geochemical particle-tracking analysis results in ArcGIS. It includes individual map packages for several regions of New Mexico including: Acoma, Rincon, Gila, Las Cruces, Socorro and Truth or Consequences.

Search for lightly ionizing particles with the MACRO detector

NASA Astrophysics Data System (ADS)

Ambrosio, M.; Antolini, R.; Auriemma, G.; Bakari, D.; Baldini, A.; Barbarino, G. C.; Barish, B. C.; Battistoni, G.; Bellotti, R.; Bemporad, C.; Bernardini, P.; Bilokon, H.; Bisi, V.; Bloise, C.; Bower, C.; Brigida, M.; Bussino, S.; Cafagna, F.; Calicchio, M.; Campana, D.; Carboni, M.; Cecchini, S.; Cei, F.; Chiarella, V.; Choudhary, B. C.; Coutu, S.; de Cataldo, G.; Dekhissi, H.; de Marzo, C.; de Mitri, I.; Derkaoui, J.; de Vincenzi, M.; di Credico, A.; Erriquez, O.; Favuzzi, C.; Forti, C.; Fusco, P.; Giacomelli, G.; Giannini, G.; Giglietto, N.; Giorgini, M.; Grassi, M.; Gray, L.; Grillo, A.; Guarino, F.; Gustavino, C.; Habig, A.; Hanson, K.; Heinz, R.; Iarocci, E.; Katsavounidis, E.; Katsavounidis, I.; Kearns, E.; Kim, H.; Kyriazopoulou, S.; Lamanna, E.; Lane, C.; Levin, D. S.; Lipari, P.; Longley, N. P.; Longo, M. J.; Loparco, F.; Maaroufi, F.; Mancarella, G.; Mandrioli, G.; Margiotta, A.; Marini, A.; Martello, D.; Marzari-Chiesa, A.; Mazziotta, M. N.; Michael, D. G.; Mikheyev, S.; Miller, L.; Monacelli, P.; Montaruli, T.; Monteno, M.; Mufson, S.; Musser, J.; Nicolò, D.; Nolty, R.; Orth, C.; Okada, C.; Osteria, G.; Ouchrif, M.; Palamara, O.; Patera, V.; Patrizii, L.; Pazzi, R.; Peck, C. W.; Perrone, L.; Petrera, S.; Pistilli, P.; Popa, V.; Rainò, A.; Reynoldson, J.; Ronga, F.; Satriano, C.; Satta, L.; Scapparone, E.; Scholberg, K.; Sciubba, A.; Serra, P.; Sioli, M.; Sitta, M.; Spinelli, P.; Spinetti, M.; Spurio, M.; Steinberg, R.; Stone, J. L.; Sulak, L. R.; Surdo, A.; Tarlè, G.; Togo, V.; Vakili, M.; Vilela, E.; Walter, C. W.; Webb, R.

2000-09-01

A search for lightly ionizing particles has been performed with the MACRO detector. This search was sensitive to particles with charges between 15 e and close to the charge of an electron, with β between approximately 0.25 and 1.0. Unlike previous searches both single track events and tracks buried within high multiplicity muon showers were examined. In a period of approximately one year no candidates were observed. Assuming an isotropic flux, for the single track sample this corresponds to a 90% C.L. upper flux limit Φ<=9.2×10-15 cm-2 s-1 sr-1.

Tracking Image Correlation: Combining Single-Particle Tracking and Image Correlation

PubMed Central

Dupont, A.; Stirnnagel, K.; Lindemann, D.; Lamb, D.C.

2013-01-01

The interactions and coordination of biomolecules are crucial for most cellular functions. The observation of protein interactions in live cells may provide a better understanding of the underlying mechanisms. After fluorescent labeling of the interacting partners and live-cell microscopy, the colocalization is generally analyzed by quantitative global methods. Recent studies have addressed questions regarding the individual colocalization of moving biomolecules, usually by using single-particle tracking (SPT) and comparing the fluorescent intensities in both color channels. Here, we introduce a new method that combines SPT and correlation methods to obtain a dynamical 3D colocalization analysis along single trajectories of dual-colored particles. After 3D tracking, the colocalization is computed at each particle’s position via the local 3D image cross correlation of the two detection channels. For every particle analyzed, the output consists of the 3D trajectory, the time-resolved 3D colocalization information, and the fluorescence intensity in both channels. In addition, the cross-correlation analysis shows the 3D relative movement of the two fluorescent labels with an accuracy of 30 nm. We apply this method to the tracking of viral fusion events in live cells and demonstrate its capacity to obtain the time-resolved colocalization status of single particles in dense and noisy environments. PMID:23746509

Developing a particle tracking surrogate model to improve inversion of ground water - Surface water models

NASA Astrophysics Data System (ADS)

Cousquer, Yohann; Pryet, Alexandre; Atteia, Olivier; Ferré, Ty P. A.; Delbart, Célestine; Valois, Rémi; Dupuy, Alain

2018-03-01

The inverse problem of groundwater models is often ill-posed and model parameters are likely to be poorly constrained. Identifiability is improved if diverse data types are used for parameter estimation. However, some models, including detailed solute transport models, are further limited by prohibitive computation times. This often precludes the use of concentration data for parameter estimation, even if those data are available. In the case of surface water-groundwater (SW-GW) models, concentration data can provide SW-GW mixing ratios, which efficiently constrain the estimate of exchange flow, but are rarely used. We propose to reduce computational limits by simulating SW-GW exchange at a sink (well or drain) based on particle tracking under steady state flow conditions. Particle tracking is used to simulate advective transport. A comparison between the particle tracking surrogate model and an advective-dispersive model shows that dispersion can often be neglected when the mixing ratio is computed for a sink, allowing for use of the particle tracking surrogate model. The surrogate model was implemented to solve the inverse problem for a real SW-GW transport problem with heads and concentrations combined in a weighted hybrid objective function. The resulting inversion showed markedly reduced uncertainty in the transmissivity field compared to calibration on head data alone.

Particle Filtering for Obstacle Tracking in UAS Sense and Avoid Applications

PubMed Central

Moccia, Antonio

2014-01-01

Obstacle detection and tracking is a key function for UAS sense and avoid applications. In fact, obstacles in the flight path must be detected and tracked in an accurate and timely manner in order to execute a collision avoidance maneuver in case of collision threat. The most important parameter for the assessment of a collision risk is the Distance at Closest Point of Approach, that is, the predicted minimum distance between own aircraft and intruder for assigned current position and speed. Since assessed methodologies can cause some loss of accuracy due to nonlinearities, advanced filtering methodologies, such as particle filters, can provide more accurate estimates of the target state in case of nonlinear problems, thus improving system performance in terms of collision risk estimation. The paper focuses on algorithm development and performance evaluation for an obstacle tracking system based on a particle filter. The particle filter algorithm was tested in off-line simulations based on data gathered during flight tests. In particular, radar-based tracking was considered in order to evaluate the impact of particle filtering in a single sensor framework. The analysis shows some accuracy improvements in the estimation of Distance at Closest Point of Approach, thus reducing the delay in collision detection. PMID:25105154

Simulations of DSB Yields and Radiation-induced Chromosomal Aberrations in Human Cells Based on the Stochastic Track Structure Induced by HZE Particles

NASA Technical Reports Server (NTRS)

Ponomarev, Artem; Plante, Ianik; George, Kerry; Wu, Honglu

2014-01-01

The formation of double-strand breaks (DSBs) and chromosomal aberrations (CAs) is of great importance in radiation research and, specifically, in space applications. We are presenting a new particle track and DNA damage model, in which the particle stochastic track structure is combined with the random walk (RW) structure of chromosomes in a cell nucleus. The motivation for this effort stems from the fact that the model with the RW chromosomes, NASARTI (NASA radiation track image) previously relied on amorphous track structure, while the stochastic track structure model RITRACKS (Relativistic Ion Tracks) was focused on more microscopic targets than the entire genome. We have combined chromosomes simulated by RWs with stochastic track structure, which uses nanoscopic dose calculations performed with the Monte-Carlo simulation by RITRACKS in a voxelized space. The new simulations produce the number of DSBs as function of dose and particle fluence for high-energy particles, including iron, carbon and protons, using voxels of 20 nm dimension. The combined model also calculates yields of radiation-induced CAs and unrejoined chromosome breaks in normal and repair deficient cells. The joined computational model is calibrated using the relative frequencies and distributions of chromosomal aberrations reported in the literature. The model considers fractionated deposition of energy to approximate dose rates of the space flight environment. The joined model also predicts of the yields and sizes of translocations, dicentrics, rings, and more complex-type aberrations formed in the G0/G1 cell cycle phase during the first cell division after irradiation. We found that the main advantage of the joined model is our ability to simulate small doses: 0.05-0.5 Gy. At such low doses, the stochastic track structure proved to be indispensable, as the action of individual delta-rays becomes more important.

Simulations of DSB Yields and Radiation-induced Chromosomal Aberrations in Human Cells Based on the Stochastic Track Structure iIduced by HZE Particles

NASA Technical Reports Server (NTRS)

Ponomarev, Artem; Plante, Ianik; George, Kerry; Wu, Honglu

2014-01-01

The formation of double-strand breaks (DSBs) and chromosomal aberrations (CAs) is of great importance in radiation research and, specifically, in space applications. We are presenting a new particle track and DNA damage model, in which the particle stochastic track structure is combined with the random walk (RW) structure of chromosomes in a cell nucleus. The motivation for this effort stems from the fact that the model with the RW chromosomes, NASARTI (NASA radiation track image) previously relied on amorphous track structure, while the stochastic track structure model RITRACKS (Relativistic Ion Tracks) was focused on more microscopic targets than the entire genome. We have combined chromosomes simulated by RWs with stochastic track structure, which uses nanoscopic dose calculations performed with the Monte-Carlo simulation by RITRACKS in a voxelized space. The new simulations produce the number of DSBs as function of dose and particle fluence for high-energy particles, including iron, carbon and protons, using voxels of 20 nm dimension. The combined model also calculates yields of radiation-induced CAs and unrejoined chromosome breaks in normal and repair deficient cells. The joined computational model is calibrated using the relative frequencies and distributions of chromosomal aberrations reported in the literature. The model considers fractionated deposition of energy to approximate dose rates of the space flight environment. The joined model also predicts of the yields and sizes of translocations, dicentrics, rings, and more complex-type aberrations formed in the G0/G1 cell cycle phase during the first cell division after irradiation. We found that the main advantage of the joined model is our ability to simulate small doses: 0.05-0.5 Gy. At such low doses, the stochastic track structure proved to be indispensable, as the action of individual delta-rays becomes more important.

Effects of nano-SiO{sub 2} particles on surface tracking characteristics of silicone rubber composites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Yong, E-mail: tjuliuyong@tju.edu.cn; Li, Zhonglei; Du, Boxue

Compared with neat silicone rubber composites (SiRCs), SiRCs filled with nano-sized SiO{sub 2} particles at weight ratios from 0.1 to 1.0 wt. % exhibit a higher surface flashover voltage and a greater resistance to surface tracking. Scanning electron microscopy images of tracking morphologies indicate that the SiO{sub 2} particles are situated in close proximity to the polymeric chains and act as bridges to stabilize the chains and maintain the structure of the composite. Higher concentrations of nano-sized SiO{sub 2} particles, however, (above 0.3 wt. %) produce defects in the molecular network which lead to reductions in both the surface flashover voltage and the resistancemore » to surface tracking, although these reduced values are still superior to those of neat SiRCs. Therefore, SiRCs filled with nano-sized SiO{sub 2} particles, especially at an optimal weight ratio (0.1 to 0.3 wt. %), may have significant potential applications as outdoor insulators for power systems.« less

Particle tracking experiments in match-index-refraction porous media.

PubMed

Lachhab, Ahmed; Zhang, You-Kuan; Muste, Marian V I

2008-01-01

A low-cost, noninvasive, three-dimensional (3D), particle tracking velocimetry system was designed and built to investigate particle movement in match-index-refraction porous media. Both a uniform load of the glass beads of the same diameter and a binary load of the glass beads of two diameters were used. The purpose of the experiments is to study the effect of the two loads on the trajectories, velocity distribution, and spreading of small physical particles. A total of 35 particles were released and tracked in the uniform load and 46 in the binary load. The 3D trajectory of each particle was recorded with two video camcorders and analyzed. It is found that the particle's velocity, trajectory, and spreading are very sensitive to its initial location and that the smaller pore size or heterogeneity in the binary load increases the particles' velocity and enhances their spreading as compared with the uniform load. The experiments also verified the previous finding that the distribution of the particle velocities are lognormal in the longitudinal direction and Gaussian in two transverse directions and that the particle spreading is much larger along the longitudinal direction than along the traverse directions.

Emissions from Ships with respect to Their Effects on Clouds.

NASA Astrophysics Data System (ADS)

Hobbs, Peter V.; Garrett, Timothy J.; Ferek, Ronald J.; Strader, Scott R.; Hegg, Dean A.; Frick, Glendon M.; Hoppel, William A.; Gasparovic, Richard F.; Russell, Lynn M.; Johnson, Douglas W.; O'Dowd, Colin; Durkee, Philip A.; Nielsen, Kurt E.; Innis, George

2000-08-01

Emissions of particles, gases, heat, and water vapor from ships are discussed with respect to their potential for changing the microstructure of marine stratiform clouds and producing the phenomenon known as `ship tracks.' Airborne measurements are used to derive emission factors of SO2 and NO from diesel-powered and steam turbine-powered ships, burning low-grade marine fuel oil (MFO); they were 15-89 and 2-25 g kg1 of fuel burned, respectively. By contrast a steam turbine-powered ship burning high-grade navy distillate fuel had an SO2 emission factor of 6 g kg1.Various types of ships, burning both MFO and navy distillate fuel, emitted from 4 × 1015 to 2 × 1016 total particles per kilogram of fuel burned (4 × 1015-1.5 × 1016 particles per second). However, diesel-powered ships burning MFO emitted particles with a larger mode radius (0.03-0.05 m) and larger maximum sizes than those powered by steam turbines burning navy distillate fuel (mode radius 0.02 m). Consequently, if the particles have similar chemical compositions, those emitted by diesel ships burning MFO will serve as cloud condensation nuclei (CCN) at lower supersaturations (and will therefore be more likely to produce ship tracks) than the particles emitted by steam turbine ships burning distillate fuel. Since steam turbine-powered ships fueled by MFO emit particles with a mode radius similar to that of diesel-powered ships fueled by MFO, it appears that, for given ambient conditions, the type of fuel burned by a ship is more important than the type of ship engine in determining whether or not a ship will produce a ship track. However, more measurements are needed to test this hypothesis.The particles emitted from ships appear to be primarily organics, possibly combined with sulfuric acid produced by gas-to-particle conversion of SO2. Comparison of model results with measurements in ship tracks suggests that the particles from ships contain only about 10% water-soluble materials. Measurements of the total particles entering marine stratiform clouds from diesel-powered ships fueled by MFO, and increases in droplet concentrations produced by these particles, show that only about 12% of the particles serve as CCN.The fluxes of heat and water vapor from ships are estimated to be 2-22 MW and 0.5-1.5 kg s1, respectively. These emissions rarely produced measurable temperature perturbations, and never produced detectable perturbations in water vapor, in the plumes from ships. Nuclear-powered ships, which emit heat but negligible particles, do not produce ship tracks. Therefore, it is concluded that heat and water vapor emissions do not play a significant role in ship track formation and that particle emissions, particularly from those burning low-grade fuel oil, are responsible for ship track formation. Subsequent papers in this special issue discuss and test these hypotheses.

Charge Identification of Highly Ionizing Particles in Desensitized Nuclear Emulsion Using High Speed Read-Out System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toshito, T.; Kodama, K.; Yusa, K.

2006-05-10

We performed an experimental study of charge identification of heavy ions from helium to carbon having energy of about 290 MeV/u using an emulsion chamber. Emulsion was desensitized by means of forced fading (refreshing) to expand a dynamic range of response to highly charged particles. For the track reconstruction and charge identification, the fully automated high speed emulsion read-out system, which was originally developed for identifying minimum ionizing particles, was used without any modification. Clear track by track charge identification up to Z=6 was demonstrated. The refreshing technique has proved to be a powerful technique to expand response of emulsionmore » film to highly ionizing particles.« less

Elastic collisions of classical point particles on a finite frictionless linear track with perfectly reflecting endpoints

NASA Astrophysics Data System (ADS)

DeLuca, R.

2006-03-01

Repeated elastic collisions of point particles on a finite frictionless linear track with perfectly reflecting endpoints are considered. The problem is analysed by means of an elementary linear algebra approach. It is found that, starting with a state consisting of a projectile particle in motion at constant velocity and a target particle at rest in a fixed known position, the points at which collisions occur on track, when plotted versus progressive numerals, corresponding to the collisions themselves, show periodic patterns for a rather large choice of values of the initial position x(0) and on the mass ratio r. For certain values of these parameters, however, only regular behaviour over a large number of collisions is detected.

Balancing Conflicting Requirements for Grid and Particle Decomposition in Continuum-Lagrangian Solvers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sitaraman, Hariswaran; Grout, Ray

2015-10-30

The load balancing strategies for hybrid solvers that involve grid based partial differential equation solution coupled with particle tracking are presented in this paper. A typical Message Passing Interface (MPI) based parallelization of grid based solves are done using a spatial domain decomposition while particle tracking is primarily done using either of the two techniques. One of the techniques is to distribute the particles to MPI ranks to whose grid they belong to while the other is to share the particles equally among all ranks, irrespective of their spatial location. The former technique provides spatial locality for field interpolation butmore » cannot assure load balance in terms of number of particles, which is achieved by the latter. The two techniques are compared for a case of particle tracking in a homogeneous isotropic turbulence box as well as a turbulent jet case. We performed a strong scaling study for more than 32,000 cores, which results in particle densities representative of anticipated exascale machines. The use of alternative implementations of MPI collectives and efficient load equalization strategies are studied to reduce data communication overheads.« less

Tracking multiple particles in fluorescence time-lapse microscopy images via probabilistic data association.

PubMed

Godinez, William J; Rohr, Karl

2015-02-01

Tracking subcellular structures as well as viral structures displayed as 'particles' in fluorescence microscopy images yields quantitative information on the underlying dynamical processes. We have developed an approach for tracking multiple fluorescent particles based on probabilistic data association. The approach combines a localization scheme that uses a bottom-up strategy based on the spot-enhancing filter as well as a top-down strategy based on an ellipsoidal sampling scheme that uses the Gaussian probability distributions computed by a Kalman filter. The localization scheme yields multiple measurements that are incorporated into the Kalman filter via a combined innovation, where the association probabilities are interpreted as weights calculated using an image likelihood. To track objects in close proximity, we compute the support of each image position relative to the neighboring objects of a tracked object and use this support to recalculate the weights. To cope with multiple motion models, we integrated the interacting multiple model algorithm. The approach has been successfully applied to synthetic 2-D and 3-D images as well as to real 2-D and 3-D microscopy images, and the performance has been quantified. In addition, the approach was successfully applied to the 2-D and 3-D image data of the recent Particle Tracking Challenge at the IEEE International Symposium on Biomedical Imaging (ISBI) 2012.

Inlet Diameter and Flow Volume Effects on Separation and Energy Efficiency of Hydrocyclones

NASA Astrophysics Data System (ADS)

Erikli, Ş.; Olcay, A. B.

2015-08-01

This study investigates hydrocyclone performance of an oil injected screw compressor. Especially, the oil separation efficiency of a screw compressor plays a significant role for air quality and non-stop working hour of compressors has become an important issue when the efficiency in energy is considered. In this study, two separation efficiency parameters were selected to be hydrocyclone inlet diameter and flow volume height between oil reservoir surface and top of the hydrocyclone. Nine different cases were studied in which cyclone inlet diameter and flow volume height between oil reservoir surface and top were investigated in regards to separation and energy performance aspects and the effect of the parameters on the general performance appears to be causing powerful influence. Flow inside the hydrocyclone geometry was modelled by Reynolds Stress Model (RSM) and hydro particles were tracked by Discrete Phase Model (DPM). Besides, particle break up was modelled by the Taylor Analogy Breakup (TAB) model. The reversed vortex generation was observed at different planes. The upper limit of the inlet diameter of the cyclone yields the centrifugal force on particles to decrease while the flow becomes slower; and the larger diameter implies slower flow. On the contrary, the lower limit is increment in speed causes breakup problems that the particle diameters become smaller; consequently, it is harder to separate them from gas.

Discriminative detection of deposited radon daughters on CR-39 track detectors using TRIAC II code

NASA Astrophysics Data System (ADS)

Patiris, D. L.; Ioannides, K. G.

2009-07-01

A method for detecting deposited 218Po and 214Po by a spectrometric study of CR-39 solid state nuclear track detectors is described. The method is based on the application of software imposed selection criteria, concerning the geometrical and optical properties of the tracks, which correspond to tracks created by alpha particles of specific energy falling on the detector at given angles of incidence. The selection criteria were based on a preliminary study of tracks' parameters (major and minor axes and mean value of brightness), using the TRIAC II code. Since no linear relation was found between the energy and the geometric characteristics of the tracks (major and minor axes), we resorted to the use of an additional parameter in order to classify the tracks according to the particles' energy. Since the brightness of tracks is associated with the tracks' depth, the mean value of brightness was chosen as the parameter of choice. To reduce the energy of the particles, which are emitted by deposited 218Po and 214Po into a quantifiable range, the detectors were covered with an aluminum absorber material. In this way, the discrimination of radon's daughters was finally accomplished by properly selecting amongst all registered tracks. This method could be applied as a low cost tool for the study of the radon's daughters behavior in air.

Nuclear particle detection using a track-recording solid

NASA Technical Reports Server (NTRS)

Weber, M.; Weber, D.

1984-01-01

The design of the nuclear particle detector located in Purdue University's Get Away Special package which was flown aboard STS-7 is detailed. The experiment consisted of a stack of particle-detecting polymer sheets. The sheets show positive results of tracks throughout the block. A slide of each sheet was made for further analysis. Recommendations for similar experiments performed in the future are discussed.

Combining particle-tracking and geochemical data to assess public supply well vulnerability to arsenic and uranium

USGS Publications Warehouse

Hinkle, S.R.; Kauffman, L.J.; Thomas, M.A.; Brown, C.J.; McCarthy, K.A.; Eberts, S.M.; Rosen, Michael R.; Katz, B.G.

2009-01-01

Flow-model particle-tracking results and geochemical data from seven study areas across the United States were analyzed using three statistical methods to test the hypothesis that these variables can successfully be used to assess public supply well vulnerability to arsenic and uranium. Principal components analysis indicated that arsenic and uranium concentrations were associated with particle-tracking variables that simulate time of travel and water fluxes through aquifer systems and also through specific redox and pH zones within aquifers. Time-of-travel variables are important because many geochemical reactions are kinetically limited, and geochemical zonation can account for different modes of mobilization and fate. Spearman correlation analysis established statistical significance for correlations of arsenic and uranium concentrations with variables derived using the particle-tracking routines. Correlations between uranium concentrations and particle-tracking variables were generally strongest for variables computed for distinct redox zones. Classification tree analysis on arsenic concentrations yielded a quantitative categorical model using time-of-travel variables and solid-phase-arsenic concentrations. The classification tree model accuracy on the learning data subset was 70%, and on the testing data subset, 79%, demonstrating one application in which particle-tracking variables can be used predictively in a quantitative screening-level assessment of public supply well vulnerability. Ground-water management actions that are based on avoidance of young ground water, reflecting the premise that young ground water is more vulnerable to anthropogenic contaminants than is old ground water, may inadvertently lead to increased vulnerability to natural contaminants due to the tendency for concentrations of many natural contaminants to increase with increasing ground-water residence time.

Shock dynamics of two-lane driven lattice gases

NASA Astrophysics Data System (ADS)

Schiffmann, Christoph; Appert-Rolland, Cécile; Santen, Ludger

2010-06-01

Driven lattice gases such as those of the ASEP model are useful tools for the modelling of various stochastic transport processes carried out by self-driven particles, such as molecular motors or vehicles in road traffic. Often these processes take place in one-dimensional systems offering several tracks to the particles, and in many cases the particles are able to change track with a given rate. In this work we consider the case of strong coupling where the rate of hopping along the tracks and the exchange rates are of the same order, and show how a phenomenological approach based on a domain wall theory can be used to describe the dynamics of the system. In particular, the domain walls on the different tracks form pairs, whose dynamics dominate the behaviour of the system.

Aerosol mass spectrometry systems and methods

DOEpatents

Fergenson, David P.; Gard, Eric E.

2013-08-20

A system according to one embodiment includes a particle accelerator that directs a succession of polydisperse aerosol particles along a predetermined particle path; multiple tracking lasers for generating beams of light across the particle path; an optical detector positioned adjacent the particle path for detecting impingement of the beams of light on individual particles; a desorption laser for generating a beam of desorbing light across the particle path about coaxial with a beam of light produced by one of the tracking lasers; and a controller, responsive to detection of a signal produced by the optical detector, that controls the desorption laser to generate the beam of desorbing light. Additional systems and methods are also disclosed.

Particle image diffusometry: Resolving diffusion coefficient field from microscopy movie data without particle tracking

NASA Astrophysics Data System (ADS)

Hanasaki, Itsuo; Ooi, Yuto

2018-06-01

We propose a technique to evaluate the field of diffusion coefficient for particle dispersion where the Brownian motion is heterogeneous in space and single particle tracking (SPT) analysis is hindered by high concentration of the particles and/or their small size. We realize this "particle image diffusometry" by the principle of the differential dynamic microscopy (DDM). We extend the DDM by introducing the automated objective decision of the scaling regime itself. Label-free evaluation of spatially non-uniform diffusion coefficients without SPT is useful in the diverse applications including crystal nucleation and glass transition where non-invasive observation is desired.

Single file diffusion into a semi-infinite tube.

PubMed

Farrell, Spencer G; Brown, Aidan I; Rutenberg, Andrew D

2015-11-23

We investigate single file diffusion (SFD) of large particles entering a semi-infinite tube, such as luminal diffusion of proteins into microtubules or flagella. While single-file effects have no impact on the evolution of particle density, we report significant single-file effects for individually tracked tracer particle motion. Both exact and approximate ordering statistics of particles entering semi-infinite tubes agree well with our stochastic simulations. Considering initially empty semi-infinite tubes, with particles entering at one end starting from an initial time t = 0, tracked particles are initially super-diffusive after entering the system, but asymptotically diffusive at later times. For finite time intervals, the ratio of the net displacement of individual single-file particles to the average displacement of untracked particles is reduced at early times and enhanced at later times. When each particle is numbered, from the first to enter (n = 1) to the most recent (n = N), we find good scaling collapse of this distance ratio for all n. Experimental techniques that track individual particles, or local groups of particles, such as photo-activation or photobleaching of fluorescently tagged proteins, should be able to observe these single-file effects. However, biological phenomena that depend on local concentration, such as flagellar extension or luminal enzymatic activity, should not exhibit single-file effects.

Flow and Jamming of Granular Materials in a Two-dimensional Hopper

NASA Astrophysics Data System (ADS)

Tang, Junyao

Flow in a hopper is both a fertile testing ground for understanding fundamental granular flow rheology and industrially highly relevant. Despite increasing research efforts in this area, a comprehensive physical theory is still lacking for both jamming and flow of granular materials in a hopper. In this work, I have designed a two dimensional (2D) hopper experiment using photoelastic particles (particles' shape: disk or ellipse), with the goal to build a bridge between macroscopic phenomenon of hopper flow and microscopic particle-scale dynamics. Through synchronized data of particle tracking and stress distributions in particles, I have shown differences between my data of the time-averaged velocity/stress profile of 2D hopper flow with previous theoretical predictions. I have also demonstrated the importance of a mechanical stable arch near the opening on controlling hopper flow rheology and suggested a heuristic phase diagram for the hopper flow/jamming transition. Another part of this thesis work is focused on studying the impact of particle shape of particles on hopper flow. By comparing particle-tracking and photoelastic data for ellipses and disks at the appropriate length scale, I have demonstrated an important role for the rotational freedom of elliptical particles in controlling flow rheology through particle tracking and stress analysis. This work has been supported by International Fine Particle Research Institute (IFPRI) .

Multi-object tracking of human spermatozoa

NASA Astrophysics Data System (ADS)

Sørensen, Lauge; Østergaard, Jakob; Johansen, Peter; de Bruijne, Marleen

2008-03-01

We propose a system for tracking of human spermatozoa in phase-contrast microscopy image sequences. One of the main aims of a computer-aided sperm analysis (CASA) system is to automatically assess sperm quality based on spermatozoa motility variables. In our case, the problem of assessing sperm quality is cast as a multi-object tracking problem, where the objects being tracked are the spermatozoa. The system combines a particle filter and Kalman filters for robust motion estimation of the spermatozoa tracks. Further, the combinatorial aspect of assigning observations to labels in the particle filter is formulated as a linear assignment problem solved using the Hungarian algorithm on a rectangular cost matrix, making the algorithm capable of handling missing or spurious observations. The costs are calculated using hidden Markov models that express the plausibility of an observation being the next position in the track history of the particle labels. Observations are extracted using a scale-space blob detector utilizing the fact that the spermatozoa appear as bright blobs in a phase-contrast microscope. The output of the system is the complete motion track of each of the spermatozoa. Based on these tracks, different CASA motility variables can be computed, for example curvilinear velocity or straight-line velocity. The performance of the system is tested on three different phase-contrast image sequences of varying complexity, both by visual inspection of the estimated spermatozoa tracks and by measuring the mean squared error (MSE) between the estimated spermatozoa tracks and manually annotated tracks, showing good agreement.

Use of a ground-water flow model with particle tracking to evaluate ground-water vulnerability, Clark County, Washington

USGS Publications Warehouse

Snyder, D.T.; Wilkinson, J.M.; Orzol, L.L.

1996-01-01

A ground-water flow model was used in conjunction with particle tracking to evaluate ground-water vulnerability in Clark County, Washington. Using the particle-tracking program, particles were placed in every cell of the flow model (about 60,000 particles) and tracked backwards in time and space upgradient along flow paths to their recharge points. A new computer program was developed that interfaces the results from a particle-tracking program with a geographic information system (GIS). The GIS was used to display and analyze the particle-tracking results. Ground-water vulnerability was evaluated by selecting parts of the ground-water flow system and combining the results with ancillary information stored in the GIS to determine recharge areas, characteristics of recharge areas, downgradient impact of land use at recharge areas, and age of ground water. Maps of the recharge areas for each hydrogeologic unit illustrate the presence of local, intermediate, or regional ground-water flow systems and emphasize the three-dimensional nature of the ground-water flow system in Clark County. Maps of the recharge points for each hydrogeologic unit were overlaid with maps depicting aquifer sensitivity as determined by DRASTIC (a measure of the pollution potential of ground water, based on the intrinsic characteristics of the near-surface unsaturated and saturated zones) and recharge from on-site waste-disposal systems. A large number of recharge areas were identified, particularly in southern Clark County, that have a high aquifer sensitivity, coincide with areas of recharge from on-site waste-disposal systems, or both. Using the GIS, the characteristics of the recharge areas were related to the downgradient parts of the ground-water system that will eventually receive flow that has recharged through these areas. The aquifer sensitivity, as indicated by DRASTIC, of the recharge areas for downgradient parts of the flow system was mapped for each hydrogeologic unit. A number of public-supply wells in Clark County may be receiving a component of water that recharged in areas that are more conducive to contaminant entry. The aquifer sensitivity maps illustrate a critical deficiency in the DRASTIC methodology: the failure to account for the dynamics of the ground-water flow system. DRASTIC indices calculated for a particular location thus do not necessarily reflect the conditions of the ground-water resources at the recharge areas to that particular location. Each hydrogeologic unit was also mapped to highlight those areas that will eventually receive flow from recharge areas with on-site waste-disposal systems. Most public-supply wells in southern Clark County may eventually receive a component of water that was recharged from on-site waste-disposal systems.Traveltimes from particle tracking were used to estimate the minimum and maximum age of ground water within each model-grid cell. Chlorofluorocarbon (CFC)-age dating of ground water from 51 wells was used to calibrate effective porosity values used for the particle- tracking program by comparison of ground-water ages determined through the use of the CFC-age dating with those calculated by the particle- tracking program. There was a 76 percent agreement in predicting the presence of modern water in the 51 wells as determined using CFCs and calculated by the particle-tracking program. Maps showing the age of ground water were prepared for all the hydrogeologic units. Areas with the youngest ground-water ages are expected to be at greatest risk for contamination from anthropogenic sources. Comparison of these maps with maps of public- supply wells in Clark County indicates that most of these wells may withdraw ground water that is, in part, less than 100 years old, and in many instances less than 10 years old. Results of the analysis showed that a single particle-tracking analysis simulating advective transport can be used to evaluate ground-water vulnerability for any part of a ground-wate

Monte Carlo charged-particle tracking and energy deposition on a Lagrangian mesh.

PubMed

Yuan, J; Moses, G A; McKenty, P W

2005-10-01

A Monte Carlo algorithm for alpha particle tracking and energy deposition on a cylindrical computational mesh in a Lagrangian hydrodynamics code used for inertial confinement fusion (ICF) simulations is presented. The straight line approximation is used to follow propagation of "Monte Carlo particles" which represent collections of alpha particles generated from thermonuclear deuterium-tritium (DT) reactions. Energy deposition in the plasma is modeled by the continuous slowing down approximation. The scheme addresses various aspects arising in the coupling of Monte Carlo tracking with Lagrangian hydrodynamics; such as non-orthogonal severely distorted mesh cells, particle relocation on the moving mesh and particle relocation after rezoning. A comparison with the flux-limited multi-group diffusion transport method is presented for a polar direct drive target design for the National Ignition Facility. Simulations show the Monte Carlo transport method predicts about earlier ignition than predicted by the diffusion method, and generates higher hot spot temperature. Nearly linear speed-up is achieved for multi-processor parallel simulations.

Faint Debris Detection by Particle Based Track-Before-Detect Method

NASA Astrophysics Data System (ADS)

Uetsuhara, M.; Ikoma, N.

2014-09-01

This study proposes a particle method to detect faint debris, which is hardly seen in single frame, from an image sequence based on the concept of track-before-detect (TBD). The most widely used detection method is detect-before-track (DBT), which firstly detects signals of targets from single frame by distinguishing difference of intensity between foreground and background then associate the signals for each target between frames. DBT is capable of tracking bright targets but limited. DBT is necessary to consider presence of false signals and is difficult to recover from false association. On the other hand, TBD methods try to track targets without explicitly detecting the signals followed by evaluation of goodness of each track and obtaining detection results. TBD has an advantage over DBT in detecting weak signals around background level in single frame. However, conventional TBD methods for debris detection apply brute-force search over candidate tracks then manually select true one from the candidates. To reduce those significant drawbacks of brute-force search and not-fully automated process, this study proposes a faint debris detection algorithm by a particle based TBD method consisting of sequential update of target state and heuristic search of initial state. The state consists of position, velocity direction and magnitude, and size of debris over the image at a single frame. The sequential update process is implemented by a particle filter (PF). PF is an optimal filtering technique that requires initial distribution of target state as a prior knowledge. An evolutional algorithm (EA) is utilized to search the initial distribution. The EA iteratively applies propagation and likelihood evaluation of particles for the same image sequences and resulting set of particles is used as an initial distribution of PF. This paper describes the algorithm of the proposed faint debris detection method. The algorithm demonstrates performance on image sequences acquired during observation campaigns dedicated to GEO breakup fragments, which would contain a sufficient number of faint debris images. The results indicate the proposed method is capable of tracking faint debris with moderate computational costs at operational level.

Reduced Noise UV Enhancement of Etch Rates for Nuclear Tracks in CR-39

NASA Astrophysics Data System (ADS)

Sheets, Rebecca; Clarkson, David; Ume, Rubab; Regan, Sean; Sangster, Craig; Padalino, Stephen; McLean, James

2016-10-01

The use of CR-39 plastic as a Solid State Nuclear Track Detector is an effective technique for obtaining data in high-energy particle experiments including inertial confinement fusion. To reveal particle tracks after irradiation, CR-39 is chemically etched in NaOH at 80°C for 6 hours, producing micron-scale signal pits at the nuclear track sites. Using CR-39 irradiated with 5.4 MeV alpha particles and 1.0 MeV protons, we show that exposing the CR-39 to high intensity UV light before etching, with wavelengths between 240 nm and 350 nm, speeds the etch process. Elevated temperatures during UV exposure amplifies this effect, with etch rates up to 50% greater than unprocessed conditions. CR-39 pieces exposed to UV light and heat can also exhibit heightened levels of etch-induced noise (surface features not caused by nuclear particles). By illuminating the CR-39 from the side opposite to the tracks, a similar level of etch enhancement was obtained with little to no noise. The effective wavelength range is reduced, due to strong attenuation of shorter wavelengths. Funded in part by a LLE contract through the DOE.

Evidence for the packaging of multiple copies of Tf1 mRNA into particles and the trans priming of reverse transcription.

PubMed

Haag, A L; Lin, J H; Levin, H L

2000-08-01

Long terminal repeat (LTR)-containing retrotransposons and retroviruses are close relatives that possess similar mechanisms of reverse transcription. The particles of retroviruses package two copies of viral mRNA that both function as templates for the reverse transcription of the element. We studied the LTR-retrotransposon Tf1 of Schizosaccharomyces pombe to test whether multiple copies of transposon mRNA participate in the production of cDNA. Using the unique self-priming property of Tf1, we obtained evidence that multiple copies of Tf1 mRNA were packaged into virus-like particles. By coexpressing two distinct versions of Tf1, we found that the bulk of reverse transcription that was initiated on one mRNA template was subsequently transferred to others. In addition, the first 11 nucleotides of one mRNA were able to prime, in trans, the reverse transcription of another mRNA.

Nonlinear dynamic model for visual object tracking on Grassmann manifolds with partial occlusion handling.

PubMed

Khan, Zulfiqar Hasan; Gu, Irene Yu-Hua

2013-12-01

This paper proposes a novel Bayesian online learning and tracking scheme for video objects on Grassmann manifolds. Although manifold visual object tracking is promising, large and fast nonplanar (or out-of-plane) pose changes and long-term partial occlusions of deformable objects in video remain a challenge that limits the tracking performance. The proposed method tackles these problems with the main novelties on: 1) online estimation of object appearances on Grassmann manifolds; 2) optimal criterion-based occlusion handling for online updating of object appearances; 3) a nonlinear dynamic model for both the appearance basis matrix and its velocity; and 4) Bayesian formulations, separately for the tracking process and the online learning process, that are realized by employing two particle filters: one is on the manifold for generating appearance particles and another on the linear space for generating affine box particles. Tracking and online updating are performed in an alternating fashion to mitigate the tracking drift. Experiments using the proposed tracker on videos captured by a single dynamic/static camera have shown robust tracking performance, particularly for scenarios when target objects contain significant nonplanar pose changes and long-term partial occlusions. Comparisons with eight existing state-of-the-art/most relevant manifold/nonmanifold trackers with evaluations have provided further support to the proposed scheme.

Automatic three-dimensional tracking of particles with high-numerical-aperture digital lensless holographic microscopy.

PubMed

Restrepo, John F; Garcia-Sucerquia, Jorge

2012-02-15

We present an automatic procedure for 3D tracking of micrometer-sized particles with high-NA digital lensless holographic microscopy. The method uses a two-feature approach to search for the best focal planes and to distinguish particles from artifacts or other elements on the reconstructed stream of the holograms. A set of reconstructed images is axially projected onto a single image. From the projected image, the centers of mass of all the reconstructed elements are identified. Starting from the centers of mass, the morphology of the profile of the maximum intensity along the reconstruction direction allows for the distinguishing of particles from others elements. The method is tested with modeled holograms and applied to automatically track micrometer-sized bubbles in a sample of 4 mm3 of soda.

Track structure in biological models.

PubMed

Curtis, S B

1986-01-01

High-energy heavy ions in the galactic cosmic radiation (HZE particles) may pose a special risk during long term manned space flights outside the sheltering confines of the earth's geomagnetic field. These particles are highly ionizing, and they and their nuclear secondaries can penetrate many centimeters of body tissue. The three dimensional patterns of ionizations they create as they lose energy are referred to as their track structure. Several models of biological action on mammalian cells attempt to treat track structure or related quantities in their formulation. The methods by which they do this are reviewed. The proximity function is introduced in connection with the theory of Dual Radiation Action (DRA). The ion-gamma kill (IGK) model introduces the radial energy-density distribution, which is a smooth function characterizing both the magnitude and extension of a charged particle track. The lethal, potentially lethal (LPL) model introduces lambda, the mean distance between relevant ion clusters or biochemical species along the track. Since very localized energy depositions (within approximately 10 nm) are emphasized, the proximity function as defined in the DRA model is not of utility in characterizing track structure in the LPL formulation.

An Integrated Approach to Indoor and Outdoor Localization

DTIC Science & Technology

2017-04-17

localization estimate, followed by particle filter based tracking. Initial localization is performed using WiFi and image observations. For tracking we...source. A two-step process is proposed that performs an initial localization es-timate, followed by particle filter based t racking. Initial...mapped, it is possible to use them for localization [20, 21, 22]. Haverinen et al. show that these fields could be used with a particle filter to

First-order reversal curves of single domain particles: diluted random assemblages and chains

NASA Astrophysics Data System (ADS)

Egli, R.

2009-04-01

Exact magnetic models can be used to calculate first-order reversal curves (FORC) of single domain (SD) particle assemblages, as shown by Newell [2005] for the case of isolated Stoner-Wohlfarth particles. After overcoming experimental difficulties, a FORC diagram sharing many similarities to Newell's model has been measured on a lake sediment sample (see A.P. Chen et al., "Quantification of magnetofossils using first-order reversal curves", EGU General Assembly 2009, Abstracts Vol. 11, EGU2009-10719). This sample contains abundant magnetofossils, as shown by coercivity analysis and electron microscopy, therefore suggesting that well dispersed, intact magnetosome chains are the main SD carriers. Subtle differences between the reversible and the irreversible contributions of the measured FORC distribution suggest that magnetosome chains might not be correctly described by the Stoner-Wohlfarth model. To better understand the hysteresis properties of such chains, a simple magnetic model has been implemented, taking dipole-dipole interactions between particles within the same chain into account. The model results depend on the magnetosome elongation, the number of magnetosomes in a chain, and the gap between them. If the chain axis is subparallel to the applied field, the magnetic moment reverses by a pseudo-fanning mode, which is replaced by a pseudo-coherent rotation mode at greater angles. These reversal modes are intrinsically different from coherent rotation assumed Stoner-Wohlfarth model, resulting in FORC diagrams with a smaller reversible component. On the other hand, isolated authigenic SD particles can precipitate in the sediment matrix, as it might occur for pedogenic magnetite. In this case, an assembly of randomly located particles provides a possible model for the resulting FORC diagram. If the concentration of the particles is small, each particle is affected by a random interaction field whose statistical distribution can be calculated from first principles. In this case, the irreversible component of the FORC diagram, which is described by a Dirac delta function in the non-interacting case, converts into a continuous function that directly reflects the distribution of interaction fields. Such models provide a way to identify and characterize authigenic SD particles in sediments, and in some case allow one to isolate their magnetic contribution from that of other magnetic components. Newell, A.J. (2005), A high-precision model of first-order reversal curve (FORC) functions for single-domain ferromagnets with uniaxial anisotropy, Gechem. Geophys. Geosyst., 6, Q05010, doi:10.1029/2004GC00877.

TrackMate: An open and extensible platform for single-particle tracking.

PubMed

Tinevez, Jean-Yves; Perry, Nick; Schindelin, Johannes; Hoopes, Genevieve M; Reynolds, Gregory D; Laplantine, Emmanuel; Bednarek, Sebastian Y; Shorte, Spencer L; Eliceiri, Kevin W

2017-02-15

We present TrackMate, an open source Fiji plugin for the automated, semi-automated, and manual tracking of single-particles. It offers a versatile and modular solution that works out of the box for end users, through a simple and intuitive user interface. It is also easily scriptable and adaptable, operating equally well on 1D over time, 2D over time, 3D over time, or other single and multi-channel image variants. TrackMate provides several visualization and analysis tools that aid in assessing the relevance of results. The utility of TrackMate is further enhanced through its ability to be readily customized to meet specific tracking problems. TrackMate is an extensible platform where developers can easily write their own detection, particle linking, visualization or analysis algorithms within the TrackMate environment. This evolving framework provides researchers with the opportunity to quickly develop and optimize new algorithms based on existing TrackMate modules without the need of having to write de novo user interfaces, including visualization, analysis and exporting tools. The current capabilities of TrackMate are presented in the context of three different biological problems. First, we perform Caenorhabditis-elegans lineage analysis to assess how light-induced damage during imaging impairs its early development. Our TrackMate-based lineage analysis indicates the lack of a cell-specific light-sensitive mechanism. Second, we investigate the recruitment of NEMO (NF-κB essential modulator) clusters in fibroblasts after stimulation by the cytokine IL-1 and show that photodamage can generate artifacts in the shape of TrackMate characterized movements that confuse motility analysis. Finally, we validate the use of TrackMate for quantitative lifetime analysis of clathrin-mediated endocytosis in plant cells. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

Synthesis of brushite particles in reverse microemulsions of the biosurfactant surfactin.

PubMed

Maity, Jyoti Prakash; Lin, Tz-Jiun; Cheng, Henry Pai-Heng; Chen, Chien-Yen; Reddy, A Satyanarayana; Atla, Shashi B; Chang, Young-Fo; Chen, Hau-Ren; Chen, Chien-Cheng

2011-01-01

In this study the "green chemistry" use of the biosurfactant surfactin for the synthesis of calcium phosphate using the reverse microemulsion technique was demonstrated. Calcium phosphates are bioactive materials that are a major constituent of human teeth and bone tissue. A reverse microemulsion technique with surfactin was used to produce nanocrystalline brushite particles. Structural diversity (analyzed by SEM and TEM) resulted from different water to surfactin ratios (W/S; 250, 500, 1000 and 40,000). The particle sizes were found to be in the 16-200 nm range. Morphological variety was observed in the as-synthesized microemulsions, which consisted of nanospheres (~16 nm in diameter) and needle-like (8-14 nm in diameter and 80-100 nm in length) noncalcinated particles. However, the calcinated products included nanospheres (50-200 nm in diameter), oval (~300 nm in diameter) and nanorod (200-400 nm in length) particles. FTIR and XRD analysis confirmed the formation of brushite nanoparticles in the as-synthesized products, while calcium pyrophosphate was produced after calcination. These results indicate that the reverse microemulsion technique using surfactin is a green process suitable for the synthesis of nanoparticles.

A multi-parametric particle-pairing algorithm for particle tracking in single and multiphase flows

NASA Astrophysics Data System (ADS)

Cardwell, Nicholas D.; Vlachos, Pavlos P.; Thole, Karen A.

2011-10-01

Multiphase flows (MPFs) offer a rich area of fundamental study with many practical applications. Examples of such flows range from the ingestion of foreign particulates in gas turbines to transport of particles within the human body. Experimental investigation of MPFs, however, is challenging, and requires techniques that simultaneously resolve both the carrier and discrete phases present in the flowfield. This paper presents a new multi-parametric particle-pairing algorithm for particle tracking velocimetry (MP3-PTV) in MPFs. MP3-PTV improves upon previous particle tracking algorithms by employing a novel variable pair-matching algorithm which utilizes displacement preconditioning in combination with estimated particle size and intensity to more effectively and accurately match particle pairs between successive images. To improve the method's efficiency, a new particle identification and segmentation routine was also developed. Validation of the new method was initially performed on two artificial data sets: a traditional single-phase flow published by the Visualization Society of Japan (VSJ) and an in-house generated MPF data set having a bi-modal distribution of particles diameters. Metrics of the measurement yield, reliability and overall tracking efficiency were used for method comparison. On the VSJ data set, the newly presented segmentation routine delivered a twofold improvement in identifying particles when compared to other published methods. For the simulated MPF data set, measurement efficiency of the carrier phases improved from 9% to 41% for MP3-PTV as compared to a traditional hybrid PTV. When employed on experimental data of a gas-solid flow, the MP3-PTV effectively identified the two particle populations and reported a vector efficiency and velocity measurement error comparable to measurements for the single-phase flow images. Simultaneous measurement of the dispersed particle and the carrier flowfield velocities allowed for the calculation of instantaneous particle slip velocities, illustrating the algorithm's strength to robustly and accurately resolve polydispersed MPFs.

Use of Inverse-Modeling Methods to Improve Ground-Water-Model Calibration and Evaluate Model-Prediction Uncertainty, Camp Edwards, Cape Cod, Massachusetts

USGS Publications Warehouse

Walter, Donald A.; LeBlanc, Denis R.

2008-01-01

Historical weapons testing and disposal activities at Camp Edwards, which is located on the Massachusetts Military Reservation, western Cape Cod, have resulted in the release of contaminants into an underlying sand and gravel aquifer that is the sole source of potable water to surrounding communities. Ground-water models have been used at the site to simulate advective transport in the aquifer in support of field investigations. Reasonable models developed by different groups and calibrated by trial and error often yield different predictions of advective transport, and the predictions lack quantitative measures of uncertainty. A recently (2004) developed regional model of western Cape Cod, modified to include the sensitivity and parameter-estimation capabilities of MODFLOW-2000, was used in this report to evaluate the utility of inverse (statistical) methods to (1) improve model calibration and (2) assess model-prediction uncertainty. Simulated heads and flows were most sensitive to recharge and to the horizontal hydraulic conductivity of the Buzzards Bay and Sandwich Moraines and the Buzzards Bay and northern parts of the Mashpee outwash plains. Conversely, simulated heads and flows were much less sensitive to vertical hydraulic conductivity. Parameter estimation (inverse calibration) improved the match to observed heads and flows; the absolute mean residual for heads improved by 0.32 feet and the absolute mean residual for streamflows improved by about 0.2 cubic feet per second. Advective-transport predictions in Camp Edwards generally were most sensitive to the parameters with the highest precision (lowest coefficients of variation), indicating that the numerical model is adequate for evaluating prediction uncertainties in and around Camp Edwards. The incorporation of an advective-transport observation, representing the leading edge of a contaminant plume that had been difficult to match by using trial-and-error calibration, improved the match between an observed and simulated plume path; however, a modified representation of local geology was needed to simultaneously maintain a reasonable calibration to heads and flows and to the plume path. Advective-transport uncertainties were expressed as about 68-, 95-, and 99-percent confidence intervals on three dimensional simulated particle positions. The confidence intervals can be graphically represented as ellipses around individual particle positions in the X-Y (geographic) plane and in the X-Z or Y-Z (vertical) planes. The merging of individual ellipses allows uncertainties on forward particle tracks to be displayed in map or cross-sectional view as a cone of uncertainty around a simulated particle path; uncertainties on reverse particle-track endpoints - representing simulated recharge locations - can be geographically displayed as areas at the water table around the discrete particle endpoints. This information gives decisionmakers insight into the level of confidence they can have in particle-tracking results and can assist them in the efficient use of available field resources.

Image computing techniques to extrapolate data for dust tracking in case of an experimental accident simulation in a nuclear fusion plant.

PubMed

Camplani, M; Malizia, A; Gelfusa, M; Barbato, F; Antonelli, L; Poggi, L A; Ciparisse, J F; Salgado, L; Richetta, M; Gaudio, P

2016-01-01

In this paper, a preliminary shadowgraph-based analysis of dust particles re-suspension due to loss of vacuum accident (LOVA) in ITER-like nuclear fusion reactors has been presented. Dust particles are produced through different mechanisms in nuclear fusion devices, one of the main issues is that dust particles are capable of being re-suspended in case of events such as LOVA. Shadowgraph is based on an expanded collimated beam of light emitted by a laser or a lamp that emits light transversely compared to the flow field direction. In the STARDUST facility, the dust moves in the flow, and it causes variations of refractive index that can be detected by using a CCD camera. The STARDUST fast camera setup allows to detect and to track dust particles moving in the vessel and then to obtain information about the velocity field of dust mobilized. In particular, the acquired images are processed such that per each frame the moving dust particles are detected by applying a background subtraction technique based on the mixture of Gaussian algorithm. The obtained foreground masks are eventually filtered with morphological operations. Finally, a multi-object tracking algorithm is used to track the detected particles along the experiment. For each particle, a Kalman filter-based tracker is applied; the particles dynamic is described by taking into account position, velocity, and acceleration as state variable. The results demonstrate that it is possible to obtain dust particles' velocity field during LOVA by automatically processing the data obtained with the shadowgraph approach.

Image computing techniques to extrapolate data for dust tracking in case of an experimental accident simulation in a nuclear fusion plant

NASA Astrophysics Data System (ADS)

Camplani, M.; Malizia, A.; Gelfusa, M.; Barbato, F.; Antonelli, L.; Poggi, L. A.; Ciparisse, J. F.; Salgado, L.; Richetta, M.; Gaudio, P.

2016-01-01

In this paper, a preliminary shadowgraph-based analysis of dust particles re-suspension due to loss of vacuum accident (LOVA) in ITER-like nuclear fusion reactors has been presented. Dust particles are produced through different mechanisms in nuclear fusion devices, one of the main issues is that dust particles are capable of being re-suspended in case of events such as LOVA. Shadowgraph is based on an expanded collimated beam of light emitted by a laser or a lamp that emits light transversely compared to the flow field direction. In the STARDUST facility, the dust moves in the flow, and it causes variations of refractive index that can be detected by using a CCD camera. The STARDUST fast camera setup allows to detect and to track dust particles moving in the vessel and then to obtain information about the velocity field of dust mobilized. In particular, the acquired images are processed such that per each frame the moving dust particles are detected by applying a background subtraction technique based on the mixture of Gaussian algorithm. The obtained foreground masks are eventually filtered with morphological operations. Finally, a multi-object tracking algorithm is used to track the detected particles along the experiment. For each particle, a Kalman filter-based tracker is applied; the particles dynamic is described by taking into account position, velocity, and acceleration as state variable. The results demonstrate that it is possible to obtain dust particles' velocity field during LOVA by automatically processing the data obtained with the shadowgraph approach.

Directional Track Selection Technique in CR39 SSNTD for lowyield reaction experiments

NASA Astrophysics Data System (ADS)

Ingenito, Francesco; Andreoli, Pierluigi; Batani, Dimitri; Bonasera, Aldo; Boutoux, Guillaume; Burgy, Frederic; Cipriani, Mattia; Consoli, Fabrizio; Cristofari, Giuseppe; De Angelis, Riccardo; Di Giorgio, Giorgio; Ducret, Jean Eric; Giulietti, Danilo; Jakubowska, Katarzyna

2018-01-01

There is a great interest in the study of p-11B aneutronic nuclear fusion reactions, both for energy production and for determination of fusion cross-sections at low energies. In this context we performed experiments at CELIA in which energetic protons, accelerated by the laser ECLIPSE, were directed toward a solid Boron target. Because of the small cross-sections at these energies the number of expected reactions is low. CR39 Solid-State Nuclear Track Detectors (SSNTD) were used to detect the alpha particles produced. Because of the low expected yield, it is difficult to discriminate the tracks due to true fusion products from those due to natural background in the CR39. To this purpose we developed a methodology of particle recognition according to their direction with respect to the detector normal, able to determine the position of their source. We applied this to the specific experiment geometry, so to select from all the tracks those due to particles coming from the region of interaction between accelerated protons and solid boron target. This technique can be of great help on the analysis of SSNTD in experiments with low yield reactions, but can be also generally applied to any experiment where particles reach the track detector with known directions, and for example to improve the detection limit of particle spectrometers using CR39.

Simulation of magnetic hysteresis loops and magnetic Barkhausen noise of α-iron containing nonmagnetic particles

DOE PAGES

Li, Yi; Xu, Ben; Hu, Shenyang; ...

2015-07-01

The magnetic hysteresis loops and Barkhausen noise of a single α-iron with nonmagnetic particles are simulated to investigate into the magnetic hardening due to Cu-rich precipitates in irradiated reactor pressure vessel (RPV) steels. Phase field method basing Landau-Lifshitz-Gilbert (LLG) equation is used for this simulation. The results show that the presence of the nonmagnetic particle could result in magnetic hardening by making the nucleation of reversed domains difficult. The coercive field is found to increase, while the intensity of Barkhausen noise voltage is decreased when the nonmagnetic particle is introduced. Simulations demonstrate the impact of nucleation field of reversed domainsmore » on the magnetization reversal behavior and the magnetic properties.« less

Particle tracking approach for transport in three-dimensional discrete fracture networks: Particle tracking in 3-D DFNs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makedonska, Nataliia; Painter, Scott L.; Bui, Quan M.

The discrete fracture network (DFN) model is a method to mimic discrete pathways for fluid flow through a fractured low-permeable rock mass, and may be combined with particle tracking simulations to address solute transport. However, experience has shown that it is challenging to obtain accurate transport results in three-dimensional DFNs because of the high computational burden and difficulty in constructing a high-quality unstructured computational mesh on simulated fractures. We present a new particle tracking capability, which is adapted to control volume (Voronoi polygons) flow solutions on unstructured grids (Delaunay triangulations) on three-dimensional DFNs. The locally mass-conserving finite-volume approach eliminates massmore » balance-related problems during particle tracking. The scalar fluxes calculated for each control volume face by the flow solver are used to reconstruct a Darcy velocity at each control volume centroid. The groundwater velocities can then be continuously interpolated to any point in the domain of interest. The control volumes at fracture intersections are split into four pieces, and the velocity is reconstructed independently on each piece, which results in multiple groundwater velocities at the intersection, one for each fracture on each side of the intersection line. This technique enables detailed particle transport representation through a complex DFN structure. Verified for small DFNs, the new simulation capability enables numerical experiments on advective transport in large DFNs to be performed. As a result, we demonstrate this particle transport approach on a DFN model using parameters similar to those of crystalline rock at a proposed geologic repository for spent nuclear fuel in Forsmark, Sweden.« less

Particle tracking approach for transport in three-dimensional discrete fracture networks: Particle tracking in 3-D DFNs

DOE PAGES

Makedonska, Nataliia; Painter, Scott L.; Bui, Quan M.; ...

2015-09-16

The discrete fracture network (DFN) model is a method to mimic discrete pathways for fluid flow through a fractured low-permeable rock mass, and may be combined with particle tracking simulations to address solute transport. However, experience has shown that it is challenging to obtain accurate transport results in three-dimensional DFNs because of the high computational burden and difficulty in constructing a high-quality unstructured computational mesh on simulated fractures. We present a new particle tracking capability, which is adapted to control volume (Voronoi polygons) flow solutions on unstructured grids (Delaunay triangulations) on three-dimensional DFNs. The locally mass-conserving finite-volume approach eliminates massmore » balance-related problems during particle tracking. The scalar fluxes calculated for each control volume face by the flow solver are used to reconstruct a Darcy velocity at each control volume centroid. The groundwater velocities can then be continuously interpolated to any point in the domain of interest. The control volumes at fracture intersections are split into four pieces, and the velocity is reconstructed independently on each piece, which results in multiple groundwater velocities at the intersection, one for each fracture on each side of the intersection line. This technique enables detailed particle transport representation through a complex DFN structure. Verified for small DFNs, the new simulation capability enables numerical experiments on advective transport in large DFNs to be performed. As a result, we demonstrate this particle transport approach on a DFN model using parameters similar to those of crystalline rock at a proposed geologic repository for spent nuclear fuel in Forsmark, Sweden.« less

Three-dimensional simulation of the motion of a single particle under a simulated turbulent velocity field

NASA Astrophysics Data System (ADS)

Moreno-Casas, P. A.; Bombardelli, F. A.

2015-12-01

A 3D Lagrangian particle tracking model is coupled to a 3D channel velocity field to simulate the saltation motion of a single sediment particle moving in saltation mode. The turbulent field is a high-resolution three dimensional velocity field that reproduces a by-pass transition to turbulence on a flat plate due to free-stream turbulence passing above de plate. In order to reduce computational costs, a decoupled approached is used, i.e., the turbulent flow is simulated independently from the tracking model, and then used to feed the 3D Lagrangian particle model. The simulations are carried using the point-particle approach. The particle tracking model contains three sub-models, namely, particle free-flight, a post-collision velocity and bed representation sub-models. The free-flight sub-model considers the action of the following forces: submerged weight, non-linear drag, lift, virtual mass, Magnus and Basset forces. The model also includes the effect of particle angular velocity. The post-collision velocities are obtained by applying conservation of angular and linear momentum. The complete model was validated with experimental results from literature within the sand range. Results for particle velocity time series and distribution of particle turbulent intensities are presented.

Nanodosimetric track structure in homogeneous extended beams.

PubMed

Conte, V; Moro, D; Colautti, P; Grosswendt, B

2015-09-01

Physical aspects of particle track structure are important in determining the induction of clustered damage in relevant subcellular structures like the DNA and higher-order genomic structures. The direct measurement of track-structure properties of ionising radiation is feasible today by counting the number of ionisations produced inside a small gas volume. In particular, the so-called track-nanodosimeter, installed at the TANDEM-ALPI accelerator complex of LNL, measures ionisation cluster-size distributions in a simulated subcellular structure of dimensions 20 nm, corresponding approximately to the diameter of the chromatin fibre. The target volume is irradiated by pencil beams of primary particles passing at specified impact parameter. To directly relate these measured track-structure data to radiobiological measurements performed in broad homogeneous particle beams, these data can be integrated over the impact parameter. This procedure was successfully applied to 240 MeV carbon ions and compared with Monte Carlo simulations for extended fields. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

2013 R&D 100 Award: DNATrax could revolutionize air quality detection and tracking

ScienceCinema

Farquar, George

2018-01-16

A team of LLNL scientists and engineers has developed a safe and versatile material, known as DNA Tagged Reagents for Aerosol Experiments (DNATrax), that can be used to reliably and rapidly diagnose airflow patterns and problems in both indoor and outdoor venues. Until DNATrax particles were developed, no rapid or safe way existed to validate air transport models with realistic particles in the range of 1-10 microns. Successful DNATrax testing was conducted at the Pentagon in November 2012 in conjunction with the Pentagon Force Protection Agency. This study enhanced the team's understanding of indoor ventilation environments created by heating, ventilation and air conditioning (HVAC) systems. DNATrax are particles comprised of sugar and synthetic DNA that serve as a bar code for the particle. The potential for creating unique bar-coded particles is virtually unlimited, thus allowing for simultaneous and repeated releases, which dramatically reduces the costs associated with conducting tests for contaminants. Among the applications for the new material are indoor air quality detection, for homes, offices, ships and airplanes; urban particulate tracking, for subway stations, train stations, and convention centers; environmental release tracking; and oil and gas uses, including fracking, to better track fluid flow.

2013 R&D 100 Award: DNATrax could revolutionize air quality detection and tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farquar, George

A team of LLNL scientists and engineers has developed a safe and versatile material, known as DNA Tagged Reagents for Aerosol Experiments (DNATrax), that can be used to reliably and rapidly diagnose airflow patterns and problems in both indoor and outdoor venues. Until DNATrax particles were developed, no rapid or safe way existed to validate air transport models with realistic particles in the range of 1-10 microns. Successful DNATrax testing was conducted at the Pentagon in November 2012 in conjunction with the Pentagon Force Protection Agency. This study enhanced the team's understanding of indoor ventilation environments created by heating, ventilationmore » and air conditioning (HVAC) systems. DNATrax are particles comprised of sugar and synthetic DNA that serve as a bar code for the particle. The potential for creating unique bar-coded particles is virtually unlimited, thus allowing for simultaneous and repeated releases, which dramatically reduces the costs associated with conducting tests for contaminants. Among the applications for the new material are indoor air quality detection, for homes, offices, ships and airplanes; urban particulate tracking, for subway stations, train stations, and convention centers; environmental release tracking; and oil and gas uses, including fracking, to better track fluid flow.« less

Track-before-detect labeled multi-bernoulli particle filter with label switching

NASA Astrophysics Data System (ADS)

Garcia-Fernandez, Angel F.

2016-10-01

This paper presents a multitarget tracking particle filter (PF) for general track-before-detect measurement models. The PF is presented in the random finite set framework and uses a labelled multi-Bernoulli approximation. We also present a label switching improvement algorithm based on Markov chain Monte Carlo that is expected to increase filter performance if targets get in close proximity for a sufficiently long time. The PF is tested in two challenging numerical examples.

Calibrations for Charged Particle Tracking with the GlueX Detector

NASA Astrophysics Data System (ADS)

Staib, Michael; GlueX Collaboration

2015-10-01

Two gas detectors comprise the tracking system for the GlueX experiment, the Central Drift Chamber (CDC) and the Forward Drift Chamber (FDC). The CDC is a cylindrical straw-tube detector covering polar angles between 6° and 168°, delivering spatial resolution of ~150 μm. The FDC is a Cathode Strip Chamber consisting of four packages, each with six alternating layers of anode wires and cathode strips. The FDC is designed to track forward-going charged particles with polar angles between 1° and 20° with a spatial resolution of ~200 μm. Both tracking detectors record timing information and energy loss measurements useful for particle identification. During Fall 2014 and Spring 2015, the first photon beam was delivered on target for commissioning of the GlueX detector in Hall-D at Jefferson Lab. These data are currently being used in a large effort to calibrate the individual detector subsystems to achieve design performance. Methods and results for calibrations of each of the tracking detectors are presented. Techniques for alignment of the tracking system using a combination of cosmic rays and beam data is discussed. Finally, some early results of physics measurements including charged final-state particles are presented. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics under Contract DE-AC05-06OR23177.

The Impact of Ship-Produced Aerosols on the Microstructure and Albedo of Warm Marine Stratocumulus Clouds: A Test of MAST Hypotheses 1i and 1ii.

NASA Astrophysics Data System (ADS)

Durkee, P. A.; Noone, K. J.; Ferek, R. J.; Johnson, D. W.; Taylor, J. P.; Garrett, T. J.; Hobbs, P. V.; Hudson, J. G.; Bretherton, C. S.; Innis, G.; Frick, G. M.; Hoppel, W. A.; O'Dowd, C. D.; Russell, L. M.; Gasparovic, R.; Nielsen, K. E.; Tessmer, S. A.; Öström, E.;  Osborne, S. R.;  Flagan, R. C.;  Seinfeld, J. H.;  Rand, H.

2000-08-01

Anomalously high reflectivity tracks in stratus and stratocumulus sheets associated with ships (known as ship tracks) are commonly seen in visible and near-infrared satellite imagery. Until now there have been only a limited number of in situ measurements made in ship tracks. The Monterey Area Ship Track (MAST) experiment, which was conducted off the coast of California in June 1994, provided a substantial dataset on ship emissions and their effects on boundary layer clouds. Several platforms, including the University of Washington C-131A aircraft, the Meteorological Research Flight C-130 aircraft, the National Aeronautics and Space Administration ER-2 aircraft, the Naval Research Laboratory airship, the Research Vessel Glorita, and dedicated U.S. Navy ships, participated in MAST in order to study processes governing the formation and maintenance of ship tracks.This paper tests the hypotheses that the cloud microphysical changes that produce ship tracks are due to (a) particulate emission from the ship's stack and/or (b) sea-salt particles from the ship's wake. It was found that ships powered by diesel propulsion units that emitted high concentrations of aerosols in the accumulation mode produced ship tracks. Ships that produced few particles (such as nuclear ships), or ships that produced high concentrations of particles but at sizes too small to be activated as cloud drops in typical stratocumulus (such as gas turbine and some steam-powered ships), did not produce ship tracks. Statistics and case studies, combined with model simulations, show that provided a cloud layer is susceptible to an aerosol perturbation, and the atmospheric stability enables aerosol to be mixed throughout the boundary layer, the direct emissions of cloud condensation nuclei from the stack of a diesel-powered ship is the most likely, if not the only, cause of the formation of ship tracks. There was no evidence that salt particles from ship wakes cause ship tracks.

Elasticity-induced force reversal between active spinning particles in dense passive media

PubMed Central

Aragones, J. L.; Steimel, J. P.; Alexander-Katz, A.

2016-01-01

The self-organization of active particles is governed by their dynamic effective interactions. Such interactions are controlled by the medium in which such active agents reside. Here we study the interactions between active agents in a dense non-active medium. Our system consists of actuated, spinning, active particles embedded in a dense monolayer of passive, or non-active, particles. We demonstrate that the presence of the passive monolayer alters markedly the properties of the system and results in a reversal of the forces between active spinning particles from repulsive to attractive. The origin of such reversal is due to the coupling between the active stresses and elasticity of the system. This discovery provides a mechanism for the interaction between active agents in complex and structured media, opening up opportunities to tune the interaction range and directionality via the mechanical properties of the medium. PMID:27112961

Tracking control of colloidal particles through non-homogeneous stationary flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Híjar, Humberto, E-mail: humberto.hijar@lasallistas.org.mx

2013-12-21

We consider the problem of controlling the trajectory of a single colloidal particle in a fluid with steady non-homogeneous flow. We use a Langevin equation to describe the dynamics of this particle, where the friction term is assumed to be given by the Faxén's Theorem for the force on a sphere immersed in a stationary flow. We use this description to propose an explicit control force field to be applied on the particle such that it will follow asymptotically any given desired trajectory, starting from an arbitrary initial condition. We show that the dynamics of the controlled particle can bemore » mapped into a set of stochastic harmonic oscillators and that the velocity gradient of the solvent induces an asymmetric coupling between them. We study the particular case of a Brownian particle controlled through a plane Couette flow and show explicitly that the velocity gradient of the solvent renders the dynamics non-stationary and non-reversible in time. We quantify this effect in terms of the correlation functions for the position of the controlled particle, which turn out to exhibit contributions depending exclusively on the non-equilibrium character of the state of the solvent. In order to test the validity of our model, we perform simulations of the controlled particle moving in a simple shear flow, using a hybrid method combining molecular dynamics and multi-particle collision dynamics. We confirm numerically that the proposed guiding force allows for controlling the trajectory of the micro-sized particle by obligating it to follow diverse specific trajectories in fluids with homogeneous shear rates of different strengths. In addition, we find that the non-equilibrium correlation functions in simulations exhibit the same qualitative behavior predicted by the model, thus revealing the presence of the asymmetric non-equilibrium coupling mechanism induced by the velocity gradient.« less

SimTrack: A compact c++ code for particle orbit and spin tracking in accelerators

DOE PAGES

Luo, Yun

2015-08-29

SimTrack is a compact c++ code of 6-d symplectic element-by-element particle tracking in accelerators originally designed for head-on beam–beam compensation simulation studies in the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory. It provides a 6-d symplectic orbit tracking with the 4th order symplectic integration for magnet elements and the 6-d symplectic synchro-beam map for beam–beam interaction. Since its inception in 2009, SimTrack has been intensively used for dynamic aperture calculations with beam–beam interaction for RHIC. Recently, proton spin tracking and electron energy loss due to synchrotron radiation were added. In this article, I will present the code architecture,more » physics models, and some selected examples of its applications to RHIC and a future electron-ion collider design eRHIC.« less

SimTrack: A compact c++ library for particle orbit and spin tracking in accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Yun

2015-06-24

SimTrack is a compact c++ library of 6-d symplectic element-by-element particle tracking in accelerators originally designed for head-on beam-beam compensation simulation studies in the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory. It provides a 6-d symplectic orbit tracking with the 4th order symplectic integration for magnet elements and the 6-d symplectic synchro-beam map for beam-beam interaction. Since its inception in 2009, SimTrack has been intensively used for dynamic aperture calculations with beam-beam interaction for RHIC. Recently, proton spin tracking and electron energy loss due to synchrotron radiation were added. In this article, I will present the code architecture,more » physics models, and some selected examples of its applications to RHIC and a future electron-ion collider design eRHIC.« less

Fish tracking by combining motion based segmentation and particle filtering

NASA Astrophysics Data System (ADS)

Bichot, E.; Mascarilla, L.; Courtellemont, P.

2006-01-01

In this paper, we suggest a new importance sampling scheme to improve a particle filtering based tracking process. This scheme relies on exploitation of motion segmentation. More precisely, we propagate hypotheses from particle filtering to blobs of similar motion to target. Hence, search is driven toward regions of interest in the state space and prediction is more accurate. We also propose to exploit segmentation to update target model. Once the moving target has been identified, a representative model is learnt from its spatial support. We refer to this model in the correction step of the tracking process. The importance sampling scheme and the strategy to update target model improve the performance of particle filtering in complex situations of occlusions compared to a simple Bootstrap approach as shown by our experiments on real fish tank sequences.

High resolution particle tracking method by suppressing the wavefront aberrations

NASA Astrophysics Data System (ADS)

Chang, Xinyu; Yang, Yuan; Kou, Li; Jin, Lei; Lu, Junsheng; Hu, Xiaodong

2018-01-01

Digital in-line holographic microscopy is one of the most efficient methods for particle tracking as it can precisely measure the axial position of particles. However, imaging systems are often limited by detector noise, image distortions and human operator misjudgment making the particles hard to locate. A general method is used to solve this problem. The normalized holograms of particles were reconstructed to the pupil plane and then fit to a linear superposition of the Zernike polynomial functions to suppress the aberrations. Relative experiments were implemented to validate the method and the results show that nanometer scale resolution was achieved even when the holograms were poorly recorded.

Earth observations taken during STS-136

NASA Image and Video Library

1995-07-04

STS071-745-006 (27 June-7 July 1995) --- This view shows a ship track, probably in the northern Pacific Ocean, where a ship has caused clouds to form more thickly directly above the path of this ship. This track is therefore visible even though the ship itself is not. Ship tracks are thought to be caused by particles thrown up into the air by the ship, from smokestack emissions and from water particles generated by the ship moving through the sea. Under favorable weather conditions, water condenses around these particles to form clouds, in this case thicker "popcorn" clouds than already exists in the area. Ongoing studies are attempting to understand this phenomenon better.

Wavelet-based tracking of bacteria in unreconstructed off-axis holograms.

PubMed

Marin, Zach; Wallace, J Kent; Nadeau, Jay; Khalil, Andre

2018-03-01

We propose an automated wavelet-based method of tracking particles in unreconstructed off-axis holograms to provide rough estimates of the presence of motion and particle trajectories in digital holographic microscopy (DHM) time series. The wavelet transform modulus maxima segmentation method is adapted and tailored to extract Airy-like diffraction disks, which represent bacteria, from DHM time series. In this exploratory analysis, the method shows potential for estimating bacterial tracks in low-particle-density time series, based on a preliminary analysis of both living and dead Serratia marcescens, and for rapidly providing a single-bit answer to whether a sample chamber contains living or dead microbes or is empty. Copyright © 2017 Elsevier Inc. All rights reserved.

Moving Particles Through a Finite Element Mesh

PubMed Central

Peskin, Adele P.; Hardin, Gary R.

1998-01-01

We present a new numerical technique for modeling the flow around multiple objects moving in a fluid. The method tracks the dynamic interaction between each particle and the fluid. The movements of the fluid and the object are directly coupled. A background mesh is designed to fit the geometry of the overall domain. The mesh is designed independently of the presence of the particles except in terms of how fine it must be to track particles of a given size. Each particle is represented by a geometric figure that describes its boundary. This figure overlies the mesh. Nodes are added to the mesh where the particle boundaries intersect the background mesh, increasing the number of nodes contained in each element whose boundary is intersected. These additional nodes are then used to describe and track the particle in the numerical scheme. Appropriate element shape functions are defined to approximate the solution on the elements with extra nodes. The particles are moved through the mesh by moving only the overlying nodes defining the particles. The regular finite element grid remains unchanged. In this method, the mesh does not distort as the particles move. Instead, only the placement of particle-defining nodes changes as the particles move. Element shape functions are updated as the nodes move through the elements. This method is especially suited for models of moderate numbers of moderate-size particles, where the details of the fluid-particle coupling are important. Both the complications of creating finite element meshes around appreciable numbers of particles, and extensive remeshing upon movement of the particles are simplified in this method. PMID:28009377

Photonic topological insulator with broken time-reversal symmetry

PubMed Central

He, Cheng; Sun, Xiao-Chen; Liu, Xiao-Ping; Lu, Ming-Hui; Chen, Yulin; Feng, Liang; Chen, Yan-Feng

2016-01-01

A topological insulator is a material with an insulating interior but time-reversal symmetry-protected conducting edge states. Since its prediction and discovery almost a decade ago, such a symmetry-protected topological phase has been explored beyond electronic systems in the realm of photonics. Electrons are spin-1/2 particles, whereas photons are spin-1 particles. The distinct spin difference between these two kinds of particles means that their corresponding symmetry is fundamentally different. It is well understood that an electronic topological insulator is protected by the electron’s spin-1/2 (fermionic) time-reversal symmetry Tf2=−1. However, the same protection does not exist under normal circumstances for a photonic topological insulator, due to photon’s spin-1 (bosonic) time-reversal symmetry Tb2=1. In this work, we report a design of photonic topological insulator using the Tellegen magnetoelectric coupling as the photonic pseudospin orbit interaction for left and right circularly polarized helical spin states. The Tellegen magnetoelectric coupling breaks bosonic time-reversal symmetry but instead gives rise to a conserved artificial fermionic-like-pseudo time-reversal symmetry, Tp (Tp2=−1), due to the electromagnetic duality. Surprisingly, we find that, in this system, the helical edge states are, in fact, protected by this fermionic-like pseudo time-reversal symmetry Tp rather than by the bosonic time-reversal symmetry Tb. This remarkable finding is expected to pave a new path to understanding the symmetry protection mechanism for topological phases of other fundamental particles and to searching for novel implementations for topological insulators. PMID:27092005

Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis.

PubMed

Müllers, Erik; Uhlig, Tobias; Stirnnagel, Kristin; Fiebig, Uwe; Zentgraf, Hanswalter; Lindemann, Dirk

2011-02-01

Prototype foamy virus (PFV) Gag lacks the characteristic orthoretroviral Cys-His motifs that are essential for various steps of the orthoretroviral replication cycle, such as RNA packaging, reverse transcription, infectivity, integration, and viral assembly. Instead, it contains three glycine-arginine-rich boxes (GR boxes) in its C terminus that putatively represent a functional equivalent. We used a four-plasmid replication-deficient PFV vector system, with uncoupled RNA genome packaging and structural protein translation, to analyze the effects of deletion and various substitution mutations within each GR box on particle release, particle-associated protein composition, RNA packaging, DNA content, infectivity, particle morphology, and intracellular localization. The degree of viral particle release by all mutants was similar to that of the wild type. Only minimal effects on Pol encapsidation, exogenous reverse transcriptase (RT) activity, and genomic viral RNA packaging were observed. In contrast, particle-associated DNA content and infectivity were drastically reduced for all deletion mutants and were undetectable for all alanine substitution mutants. Furthermore, GR box I mutants had significant changes in particle morphology, and GR box II mutants lacked the typical nuclear localization pattern of PFV Gag. Finally, it could be shown that GR boxes I and III, but not GR box II, can functionally complement each other. It therefore appears that, similar to the orthoretroviral Cys-His motifs, the PFV Gag GR boxes are important for RNA encapsidation, genome reverse transcription, and virion infectivity as well as for particle morphogenesis.

WE-H-BRA-08: A Monte Carlo Cell Nucleus Model for Assessing Cell Survival Probability Based On Particle Track Structure Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, B; Georgia Institute of Technology, Atlanta, GA; Wang, C

Purpose: To correlate the damage produced by particles of different types and qualities to cell survival on the basis of nanodosimetric analysis and advanced DNA structures in the cell nucleus. Methods: A Monte Carlo code was developed to simulate subnuclear DNA chromatin fibers (CFs) of 30nm utilizing a mean-free-path approach common to radiation transport. The cell nucleus was modeled as a spherical region containing 6000 chromatin-dense domains (CDs) of 400nm diameter, with additional CFs modeled in a sparser interchromatin region. The Geant4-DNA code was utilized to produce a particle track database representing various particles at different energies and dose quantities.more » These tracks were used to stochastically position the DNA structures based on their mean free path to interaction with CFs. Excitation and ionization events intersecting CFs were analyzed using the DBSCAN clustering algorithm for assessment of the likelihood of producing DSBs. Simulated DSBs were then assessed based on their proximity to one another for a probability of inducing cell death. Results: Variations in energy deposition to chromatin fibers match expectations based on differences in particle track structure. The quality of damage to CFs based on different particle types indicate more severe damage by high-LET radiation than low-LET radiation of identical particles. In addition, the model indicates more severe damage by protons than of alpha particles of same LET, which is consistent with differences in their track structure. Cell survival curves have been produced showing the L-Q behavior of sparsely ionizing radiation. Conclusion: Initial results indicate the feasibility of producing cell survival curves based on the Monte Carlo cell nucleus method. Accurate correlation between simulated DNA damage to cell survival on the basis of nanodosimetric analysis can provide insight into the biological responses to various radiation types. Current efforts are directed at producing cell survival curves for high-LET radiation.« less

A study of bauxite tailing quality improvement by reverse flotation

NASA Astrophysics Data System (ADS)

Wulandari, W.; Purwasasmita, M.; Sanwani, E.; Malatsih, W.; Fadilla, F.

2018-01-01

The pre-treatment of bauxite ore from Tayan, West Kalimantan includes washing and screening fine bauxite particles (-2mm) prior as the feed to the Bayer process for producing alumina. These fine particles are believed to have high content of silica which is detrimental to the process. This washed bauxite tailing still has a significant amount of alumina content. Previous research has indicated that bauxite ore can be upgraded by applying reverse flotation method to reduce its silica content in the ore. Therefore, this study is aimed to utilize reverse flotation method to recover alumina content from washed bauxite tailing. The reverse flotation experiments were carried out at pH of 6 and 8; while the particle sizes were varied at - 140+270 mesh and -270 mesh, using a batch and circuit configuration. The result of this study shows that the batch reverse flotation can recover alumina in the tailing up to 81.4%, however the silica content is still significant. The complexity of silica-alumina minerals in the tailing prevents a complete separation of the ores by only using reverse flotation.

Online Simulation of Radiation Track Structure Project

NASA Technical Reports Server (NTRS)

Plante, Ianik

2015-01-01

Space radiation comprises protons, helium and high charged and energy (HZE) particles. High-energy particles are a concern for human space flight, because they are no known options for shielding astronauts from them. When these ions interact with matter, they damage molecules and create radiolytic species. The pattern of energy deposition and positions of the radiolytic species, called radiation track structure, is highly dependent on the charge and energy of the ion. The radiolytic species damage biological molecules, which may lead to several long-term health effects such as cancer. Because of the importance of heavy ions, the radiation community is very interested in the interaction of HZE particles with DNA, notably with regards to the track structure. A desktop program named RITRACKS was developed to simulate radiation track structure. The goal of this project is to create a web interface to allow registered internal users to use RITRACKS remotely.

Micro-heterogeneity of corn hulls cellulosic fiber biopolymer studied by multiple-particle tracking (MPT)

USDA-ARS?s Scientific Manuscript database

A novel technique named multiple-particle tracking (MPT) was used to investigate the micro-structural heterogeneities of Z-trim, a zero calorie cellulosic fiber biopolymer produced from corn hulls. The principle of MPT technique is to monitor the thermally driven motion of inert micro-spheres, which...

Using the Image Analysis Method for Describing Soil Detachment by a Single Water Drop Impact

PubMed Central

Ryżak, Magdalena; Bieganowski, Andrzej

2012-01-01

The aim of the present work was to develop a method based on image analysis for describing soil detachment caused by the impact of a single water drop. The method consisted of recording tracks made by splashed particles on blotting paper under an optical microscope. The analysis facilitated division of the recorded particle tracks on the paper into drops, “comets” and single particles. Additionally, the following relationships were determined: (i) the distances of splash; (ii) the surface areas of splash tracks into relation to distance; (iii) the surface areas of the solid phase transported over a given distance; and (iv) the ratio of the solid phase to the splash track area in relation to distance. Furthermore, the proposed method allowed estimation of the weight of soil transported by a single water drop splash in relation to the distance of the water drop impact. It was concluded that the method of image analysis of splashed particles facilitated analysing the results at very low water drop energy and generated by single water drops.

Two-dimensional interpreter for field-reversed configurations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steinhauer, Loren, E-mail: lstein@uw.edu

2014-08-15

An interpretive method is developed for extracting details of the fully two-dimensional (2D) “internal” structure of field-reversed configurations (FRC) from common diagnostics. The challenge is that only external and “gross” diagnostics are routinely available in FRC experiments. Inferring such critical quantities as the poloidal flux and the particle inventory has commonly relied on a theoretical construct based on a quasi-one-dimensional approximation. Such inferences sometimes differ markedly from the more accurate, fully 2D reconstructions of equilibria. An interpreter based on a fully 2D reconstruction is needed to enable realistic within-the-shot tracking of evolving equilibrium properties. Presented here is a flexible equilibriummore » reconstruction with which an extensive data base of equilibria was constructed. An automated interpreter then uses this data base as a look-up table to extract evolving properties. This tool is applied to data from the FRC facility at Tri Alpha Energy. It yields surprising results at several points, such as the inferences that the local β (plasma pressure/external magnetic pressure) of the plasma climbs well above unity and the poloidal flux loss time is somewhat longer than previously thought, both of which arise from full two-dimensionality of FRCs.« less

The closing behavior of mechanical aortic heart valve prostheses.

PubMed

Lu, Po-Chien; Liu, Jia-Shing; Huang, Ren-Hong; Lo, Chi-Wen; Lai, Ho-Cheng; Hwang, Ned H C

2004-01-01

Mechanical artificial heart valves rely on reverse flow to close their leaflets. This mechanism creates regurgitation and water hammer effects that may form cavitations, damage blood cells, and cause thromboembolism. This study analyzes closing mechanisms of monoleaflet (Medtronic Hall 27), bileaflet (Carbo-Medics 27; St. Jude Medical 27; Duromedics 29), and trileaflet valves in a circulatory mock loop, including an aortic root with three sinuses. Downstream flow field velocity was measured via digital particle image velocimetry (DPIV). A high speed camera (PIVCAM 10-30 CCD video camera) tracked leaflet movement at 1000 frames/s. All valves open in 40-50 msec, but monoleaflet and bileaflet valves close in much less time (< 35 msec) than the trileaflet valve (>75 msec). During acceleration phase of systole, the monoleaflet forms a major and minor flow, the bileaflet has three jet flows, and the trileaflet produces a single central flow like physiologic valves. In deceleration phase, the aortic sinus vortices hinder monoleaflet and bileaflet valve closure until reverse flows and high negative transvalvular pressure push the leaflets rapidly for a hard closure. Conversely, the vortices help close the trileaflet valve more softly, probably causing less damage, lessening back flow, and providing a washing effect that may prevent thrombosis formation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rojas-Herrera, J., E-mail: jimmy06@mit.edu; Rinderknecht, H. G.; Zylstra, A. B.

The CR-39 nuclear track detector is used in many nuclear diagnostics fielded at inertial confinement fusion (ICF) facilities. Large x-ray fluences generated by ICF experiments may impact the CR-39 response to incident charged particles. To determine the impact of x-ray exposure on the CR-39 response to alpha particles, a thick-target bremsstrahlung x-ray generator was used to expose CR-39 to various doses of 8 keV Cu-K{sub α} and K{sub β} x-rays. The CR-39 detectors were then exposed to 1–5.5 MeV alphas from an Am-241 source. The regions of the CR-39 exposed to x-rays showed a smaller track diameter than those notmore » exposed to x-rays: for example, a dose of 3.0 ± 0.1 Gy causes a decrease of (19 ± 2)% in the track diameter of a 5.5 MeV alpha particle, while a dose of 60.0 ± 1.3 Gy results in a decrease of (45 ± 5)% in the track diameter. The reduced track diameters were found to be predominantly caused by a comparable reduction in the bulk etch rate of the CR-39 with x-ray dose. A residual effect depending on alpha particle energy is characterized using an empirical formula.« less

STED microscopy visualizes energy deposition of single ions in a solid-state detector beyond diffraction limit

NASA Astrophysics Data System (ADS)

Niklas, M.; Henrich, M.; Jäkel, O.; Engelhardt, J.; Abdollahi, A.; Greilich, S.

2017-05-01

Fluorescent nuclear track detectors (FNTDs) allow for visualization of single-particle traversal in clinical ion beams. The point spread function of the confocal readout has so far hindered a more detailed characterization of the track spots—the ion’s characteristic signature left in the FNTD. Here we report on the readout of the FNTD by optical nanoscopy, namely stimulated emission depletion microscopy. It was firstly possible to visualize the track spots of carbon ions and protons beyond the diffraction limit of conventional light microscopy with a resolving power of approximately 80 nm (confocal: 320 nm). A clear discrimination of the spatial width, defined by the full width half maximum of track spots from particles (proton and carbon ions), with a linear energy transfer (LET) ranging from approximately 2-1016 keV µm-1 was possible. Results suggest that the width depends on LET but not on particle charge within the uncertainties. A discrimination of particle type by width thus does not seem possible (as well as with confocal microscopy). The increased resolution, however, could allow for refined determination of the cross-sectional area facing substantial energy deposition. This work could pave the way towards development of optical nanoscopy-based analysis of radiation-induced cellular response using cell-fluorescent ion track hybrid detectors.

Performance of the ATLAS track reconstruction algorithms in dense environments in LHC Run 2.

PubMed

Aaboud, M; Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Abeloos, B; Abidi, S H; AbouZeid, O S; Abraham, N L; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, B S; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adye, T; Affolder, A A; Agatonovic-Jovin, T; Agheorghiesei, C; Aguilar-Saavedra, J A; Ahlen, S P; Ahmadov, F; Aielli, G; Akatsuka, S; Akerstedt, H; Åkesson, T P A; Akimov, A V; Alberghi, G L; Albert, J; Albicocco, P; Alconada Verzini, M J; Aleksa, M; Aleksandrov, I N; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Aliev, M; Alimonti, G; Alison, J; Alkire, S P; Allbrooke, B M M; Allen, B W; Allport, P P; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, A A; Alstaty, M; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, M G; Amadio, B T; Amaral Coutinho, Y; Amelung, C; Amidei, D; Santos, S P Amor Dos; Amorim, A; Amoroso, S; Amundsen, G; Anastopoulos, C; Ancu, L S; Andari, N; Andeen, T; Anders, C F; Anders, J K; Anderson, K J; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, A V; Anjos, N; Annovi, A; Antel, C; Antonelli, M; Antonov, A; Antrim, D J; Anulli, F; Aoki, M; Aperio Bella, L; Arabidze, G; Arai, Y; Araque, J P; Araujo Ferraz, V; Arce, A T H; Ardell, R E; Arduh, F A; Arguin, J-F; Argyropoulos, S; Arik, M; Armbruster, A J; Armitage, L J; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, N B; Augsten, K; Avolio, G; Axen, B; Ayoub, M K; Azuelos, G; Baas, A E; Baca, M J; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagnaia, P; Bahrasemani, H; Baines, J T; Bajic, M; Baker, O K; Baldin, E M; Balek, P; Balli, F; Balunas, W K; Banas, E; Banerjee, Sw; Bannoura, A A E; Barak, L; Barberio, E L; Barberis, D; Barbero, M; Barillari, T; Barisits, M-S; Barklow, T; Barlow, N; Barnes, S L; Barnett, B M; Barnett, R M; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, A J; Barranco Navarro, L; Barreiro, F; Barreiro Guimarães da Costa, J; Bartoldus, R; Barton, A E; Bartos, P; Basalaev, A; Bassalat, A; Bates, R L; Batista, S J; Batley, J R; Battaglia, M; Bauce, M; Bauer, F; Bawa, H S; Beacham, J B; Beattie, M D; Beau, T; Beauchemin, P H; Bechtle, P; Beck, H P; Becker, K; Becker, M; Beckingham, M; Becot, C; Beddall, A J; Beddall, A; Bednyakov, V A; Bedognetti, M; Bee, C P; Beermann, T A; Begalli, M; Begel, M; Behr, J K; Bell, A S; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Belyaev, N L; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Benhar Noccioli, E; Benitez, J; Benjamin, D P; Benoit, M; Bensinger, J R; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Bergeaas Kuutmann, E; Berger, N; Beringer, J; Berlendis, S; Bernard, N R; Bernardi, G; Bernius, C; Bernlochner, F U; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertram, I A; Bertsche, C; Bertsche, D; Besjes, G J; Bessidskaia Bylund, O; Bessner, M; Besson, N; Betancourt, C; Bethani, A; Bethke, S; Bevan, A J; Beyer, J; Bianchi, R M; Biebel, O; Biedermann, D; Bielski, R; Biesuz, N V; Biglietti, M; Billoud, T R V; Bilokon, H; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Bittrich, C; Bjergaard, D M; Black, C W; Black, J E; Black, K M; Blair, R E; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blum, W; Blumenschein, U; Blunier, S; Bobbink, G J; Bobrovnikov, V S; Bocchetta, S S; Bocci, A; Bock, C; Boehler, M; Boerner, D; Bogavac, D; Bogdanchikov, A G; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, A S; Bolz, A E; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Boscherini, D; Bosman, M; Bossio Sola, J D; Boudreau, J; Bouffard, J; Bouhova-Thacker, E V; Boumediene, D; Bourdarios, C; Boutle, S K; Boveia, A; Boyd, J; Boyko, I R; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, J E; Breaden Madden, W D; Brendlinger, K; Brennan, A J; Brenner, L; Brenner, R; Bressler, S; Briglin, D L; Bristow, T M; Britton, D; Britzger, D; Brochu, F M; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, W K; Brosamer, J; Brost, E; Broughton, J H; de Renstrom, P A Bruckman; Bruncko, D; Bruni, A; Bruni, G; Bruni, L S; Brunt, B H; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, A G; Budagov, I A; Buehrer, F; Bugge, M K; Bulekov, O; Bullock, D; Burch, T J; Burckhart, H; Burdin, S; Burgard, C D; Burger, A M; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, J T P; Busato, E; Büscher, D; Büscher, V; Bussey, P; Butler, J M; Buttar, C M; Butterworth, J M; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, A R; Cabrera Urbán, S; Caforio, D; Cairo, V M; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, L P; Calvente Lopez, S; Calvet, D; Calvet, S; Calvet, T P; Camacho Toro, R; Camarda, S; Camarri, P; Cameron, D; Caminal Armadans, R; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, V; Cano Bret, M; Cantero, J; Cao, T; Capeans Garrido, M D M; Caprini, I; Caprini, M; Capua, M; Carbone, R M; Cardarelli, R; Cardillo, F; Carli, I; Carli, T; Carlino, G; Carlson, B T; Carminati, L; Carney, R M D; Caron, S; Carquin, E; Carrá, S; Carrillo-Montoya, G D; Carvalho, J; Casadei, D; Casado, M P; Casolino, M; Casper, D W; Castelijn, R; Castillo Gimenez, V; Castro, N F; Catinaccio, A; Catmore, J R; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; Cerda Alberich, L; Cerqueira, A S; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, S A; Chafaq, A; Chakraborty, D; Chan, S K; Chan, W S; Chan, Y L; Chang, P; Chapman, J D; Charlton, D G; Chau, C C; Chavez Barajas, C A; Che, S; Cheatham, S; Chegwidden, A; Chekanov, S; Chekulaev, S V; Chelkov, G A; Chelstowska, M A; Chen, C; Chen, H; Chen, S; Chen, S; Chen, X; Chen, Y; Cheng, H C; Cheng, H J; Cheplakov, A; Cheremushkina, E; Cherkaoui El Moursli, R; Chernyatin, V; Cheu, E; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, A S; Chitan, A; Chiu, Y H; Chizhov, M V; Choi, K; Chomont, A R; Chouridou, S; Christodoulou, V; Chromek-Burckhart, D; Chu, M C; Chudoba, J; Chuinard, A J; Chwastowski, J J; Chytka, L; Ciftci, A K; Cinca, D; Cindro, V; Cioara, I A; Ciocca, C; Ciocio, A; Cirotto, F; Citron, Z H; Citterio, M; Ciubancan, M; Clark, A; Clark, B L; Clark, M R; Clark, P J; Clarke, R N; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Colasurdo, L; Cole, B; Colijn, A P; Collot, J; Colombo, T; Conde Muiño, P; Coniavitis, E; Connell, S H; Connelly, I A; Constantinescu, S; Conti, G; Conventi, F; Cooke, M; Cooper-Sarkar, A M; Cormier, F; Cormier, K J R; Corradi, M; Corriveau, F; Cortes-Gonzalez, A; Cortiana, G; Costa, G; Costa, M J; Costanzo, D; Cottin, G; Cowan, G; Cox, B E; Cranmer, K; Crawley, S J; Creager, R A; Cree, G; Crépé-Renaudin, S; Crescioli, F; Cribbs, W A; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; Cuhadar Donszelmann, T; Cukierman, A R; Cummings, J; Curatolo, M; Cúth, J; Czirr, H; Czodrowski, P; D'amen, G; D'Auria, S; D'eramo, L; D'Onofrio, M; Da Cunha Sargedas De Sousa, M J; Via, C Da; Dabrowski, W; Dado, T; Dai, T; Dale, O; Dallaire, F; Dallapiccola, C; Dam, M; Dandoy, J R; Daneri, M F; Dang, N P; Daniells, A C; Dann, N S; Danninger, M; Hoffmann, M Dano; Dao, V; Darbo, G; Darmora, S; Dassoulas, J; Dattagupta, A; Daubney, T; Davey, W; David, C; Davidek, T; Davies, M; Davis, D R; Davison, P; Dawe, E; Dawson, I; De, K; de Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; De Vasconcelos Corga, K; De Vivie De Regie, J B; Dearnaley, W J; Debbe, R; Debenedetti, C; Dedovich, D V; Dehghanian, N; Deigaard, I; Del Gaudio, M; Del Peso, J; Prete, T Del; Delgove, D; Deliot, F; Delitzsch, C M; Dell'Acqua, A; Dell'Asta, L; Dell'Orso, M; Della Pietra, M; Della Volpe, D; Delmastro, M; Delporte, C; Delsart, P A; DeMarco, D A; Demers, S; Demichev, M; Demilly, A; Denisov, S P; Denysiuk, D; Derendarz, D; Derkaoui, J E; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, M R; Deviveiros, P O; Dewhurst, A; Dhaliwal, S; Di Bello, F A; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, W K; Di Donato, C; Di Girolamo, A; Di Girolamo, B; Di Micco, B; Di Nardo, R; Di Petrillo, K F; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; Diamond, M; Dias, F A; Diaz, M A; Diehl, E B; Dietrich, J; Díez Cornell, S; Dimitrievska, A; Dingfelder, J; Dita, P; Dita, S; Dittus, F; Djama, F; Djobava, T; Djuvsland, J I; do Vale, M A B; Dobos, D; Dobre, M; Doglioni, C; Dolejsi, J; Dolezal, Z; Donadelli, M; Donati, S; Dondero, P; Donini, J; Dopke, J; Doria, A; Dova, M T; Doyle, A T; Drechsler, E; Dris, M; Du, Y; Duarte-Campderros, J; Dubreuil, A; Duchovni, E; Duckeck, G; Ducourthial, A; Ducu, O A; Duda, D; Dudarev, A; Dudder, A Chr; Duffield, E M; Duflot, L; Dührssen, M; Dumancic, M; Dumitriu, A E; Duncan, A K; Dunford, M; Duran Yildiz, H; Düren, M; Durglishvili, A; Duschinger, D; Dutta, B; Dyndal, M; Eckardt, C; Ecker, K M; Edgar, R C; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; Kacimi, M El; Kosseifi, R El; Ellajosyula, V; Ellert, M; Elles, S; Ellinghaus, F; Elliot, A A; Ellis, N; Elmsheuser, J; Elsing, M; Emeliyanov, D; Enari, Y; Endner, O C; Ennis, J S; Erdmann, J; Ereditato, A; Ernis, G; Ernst, M; Errede, S; Escalier, M; Escobar, C; Esposito, B; Estrada Pastor, O; Etienvre, A I; Etzion, E; Evans, H; Ezhilov, A; Ezzi, M; Fabbri, F; Fabbri, L; Facini, G; Fakhrutdinov, R M; Falciano, S; Falla, R J; Faltova, J; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farina, C; Farina, E M; Farooque, T; Farrell, S; Farrington, S M; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Faucci Giannelli, M; Favareto, A; Fawcett, W J; Fayard, L; Fedin, O L; Fedorko, W; Feigl, S; Feligioni, L; Feng, C; Feng, E J; Feng, H; Fenton, M J; Fenyuk, A B; Feremenga, L; Fernandez Martinez, P; Fernandez Perez, S; Ferrando, J; Ferrari, A; Ferrari, P; Ferrari, R; Ferreira de Lima, D E; Ferrer, A; Ferrere, D; Ferretti, C; Fiedler, F; Filipčič, A; Filipuzzi, M; Filthaut, F; Fincke-Keeler, M; Finelli, K D; Fiolhais, M C N; Fiorini, L; Fischer, A; Fischer, C; Fischer, J; Fisher, W C; Flaschel, N; Fleck, I; Fleischmann, P; Fletcher, R R M; Flick, T; Flierl, B M; Flores Castillo, L R; Flowerdew, M J; Forcolin, G T; Formica, A; Förster, F A; Forti, A; Foster, A G; Fournier, D; Fox, H; Fracchia, S; Francavilla, P; Franchini, M; Franchino, S; Francis, D; Franconi, L; Franklin, M; Frate, M; Fraternali, M; Freeborn, D; Fressard-Batraneanu, S M; Freund, B; Froidevaux, D; Frost, J A; Fukunaga, C; Fusayasu, T; Fuster, J; Gabaldon, C; Gabizon, O; Gabrielli, A; Gabrielli, A; Gach, G P; Gadatsch, S; Gadomski, S; Gagliardi, G; Gagnon, L G; Galea, C; Galhardo, B; Gallas, E J; Gallop, B J; Gallus, P; Galster, G; Gan, K K; Ganguly, S; Gao, Y; Gao, Y S; Garay Walls, F M; García, C; García Navarro, J E; Garcia-Sciveres, M; Gardner, R W; Garelli, N; Garonne, V; Gascon Bravo, A; Gasnikova, K; Gatti, C; Gaudiello, A; Gaudio, G; Gavrilenko, I L; Gay, C; Gaycken, G; Gazis, E N; Gee, C N P; Geisen, J; Geisen, M; Geisler, M P; Gellerstedt, K; Gemme, C; Genest, M H; Geng, C; Gentile, S; Gentsos, C; George, S; Gerbaudo, D; Gershon, A; Geßner, G; Ghasemi, S; Ghneimat, M; Giacobbe, B; Giagu, S; Giannetti, P; Gibson, S M; Gignac, M; Gilchriese, M; Gillberg, D; Gilles, G; Gingrich, D M; Giokaris, N; Giordani, M P; Giorgi, F M; Giraud, P F; Giromini, P; Giugni, D; Giuli, F; Giuliani, C; Giulini, M; Gjelsten, B K; Gkaitatzis, S; Gkialas, I; Gkougkousis, E L; Gkountoumis, P; Gladilin, L K; Glasman, C; Glatzer, J; Glaysher, P C F; Glazov, A; Goblirsch-Kolb, M; Godlewski, J; Goldfarb, S; Golling, T; Golubkov, D; Gomes, A; Gonçalo, R; Goncalves Gama, R; Goncalves Pinto Firmino Da Costa, J; Gonella, G; Gonella, L; Gongadze, A; González de la Hoz, S; Gonzalez-Sevilla, S; Goossens, L; Gorbounov, P A; Gordon, H A; Gorelov, I; Gorini, B; Gorini, E; Gorišek, A; Goshaw, A T; Gössling, C; Gostkin, M I; Gottardo, C A; Goudet, C R; Goujdami, D; Goussiou, A G; Govender, N; Gozani, E; Graber, L; Grabowska-Bold, I; Gradin, P O J; Gramling, J; Gramstad, E; Grancagnolo, S; Gratchev, V; Gravila, P M; Gray, C; Gray, H M; Greenwood, Z D; Grefe, C; Gregersen, K; Gregor, I M; Grenier, P; Grevtsov, K; Griffiths, J; Grillo, A A; Grimm, K; Grinstein, S; Gris, Ph; Grivaz, J-F; Groh, S; Gross, E; Grosse-Knetter, J; Grossi, G C; Grout, Z J; Grummer, A; Guan, L; Guan, W; Guenther, J; Guescini, F; Guest, D; Gueta, O; Gui, B; Guido, E; Guillemin, T; Guindon, S; Gul, U; Gumpert, C; Guo, J; Guo, W; Guo, Y; Gupta, R; Gupta, S; Gustavino, G; Gutierrez, P; Gutierrez Ortiz, N G; Gutschow, C; Guyot, C; Guzik, M P; Gwenlan, C; Gwilliam, C B; Haas, A; Haber, C; Hadavand, H K; Haddad, N; Hadef, A; Hageböck, S; Hagihara, M; Hakobyan, H; Haleem, M; Haley, J; Halladjian, G; Hallewell, G D; Hamacher, K; Hamal, P; Hamano, K; Hamilton, A; Hamity, G N; Hamnett, P G; Han, L; Han, S; Hanagaki, K; Hanawa, K; Hance, M; Haney, B; Hanke, P; Hansen, J B; Hansen, J D; Hansen, M C; Hansen, P H; Hara, K; Hard, A S; Harenberg, T; Hariri, F; Harkusha, S; Harrington, R D; Harrison, P F; Hartmann, N M; Hasegawa, M; Hasegawa, Y; Hasib, A; Hassani, S; Haug, S; Hauser, R; Hauswald, L; Havener, L B; Havranek, M; Hawkes, C M; Hawkings, R J; Hayakawa, D; Hayden, D; Hays, C P; Hays, J M; Hayward, H S; Haywood, S J; Head, S J; Heck, T; Hedberg, V; Heelan, L; Heidegger, K K; Heim, S; Heim, T; Heinemann, B; Heinrich, J J; Heinrich, L; Heinz, C; Hejbal, J; Helary, L; Held, A; Hellman, S; Helsens, C; Henderson, R C W; Heng, Y; Henkelmann, S; Henriques Correia, A M; Henrot-Versille, S; Herbert, G H; Herde, H; Herget, V; Hernández Jiménez, Y; Herr, H; Herten, G; Hertenberger, R; Hervas, L; Herwig, T C; Hesketh, G G; Hessey, N P; Hetherly, J W; Higashino, S; Higón-Rodriguez, E; Hill, E; Hill, J C; Hiller, K H; Hillier, S J; Hils, M; Hinchliffe, I; Hirose, M; Hirschbuehl, D; Hiti, B; Hladik, O; Hoad, X; Hobbs, J; Hod, N; Hodgkinson, M C; Hodgson, P; Hoecker, A; Hoeferkamp, M R; Hoenig, F; Hohn, D; Holmes, T R; Homann, M; Honda, S; Honda, T; Hong, T M; Hooberman, B H; Hopkins, W H; Horii, Y; Horton, A J; Hostachy, J-Y; Hou, S; Hoummada, A; Howarth, J; Hoya, J; Hrabovsky, M; Hrdinka, J; Hristova, I; Hrivnac, J; Hryn'ova, T; Hrynevich, A; Hsu, P J; Hsu, S-C; Hu, Q; Hu, S; Huang, Y; Hubacek, Z; Hubaut, F; Huegging, F; Huffman, T B; Hughes, E W; Hughes, G; Huhtinen, M; Huo, P; Huseynov, N; Huston, J; Huth, J; Iacobucci, G; Iakovidis, G; Ibragimov, I; Iconomidou-Fayard, L; Idrissi, Z; Iengo, P; Igonkina, O; Iizawa, T; Ikegami, Y; Ikeno, M; Ilchenko, Y; Iliadis, D; Ilic, N; Introzzi, G; Ioannou, P; Iodice, M; Iordanidou, K; Ippolito, V; Isacson, M F; Ishijima, N; Ishino, M; Ishitsuka, M; Issever, C; Istin, S; Ito, F; Iturbe Ponce, J M; Iuppa, R; Iwasaki, H; Izen, J M; Izzo, V; Jabbar, S; Jackson, P; Jacobs, R M; Jain, V; Jakobi, K B; Jakobs, K; Jakobsen, S; Jakoubek, T; Jamin, D O; Jana, D K; Jansky, R; Janssen, J; Janus, M; Janus, P A; Jarlskog, G; Javadov, N; Javůrek, T; Javurkova, M; Jeanneau, F; Jeanty, L; Jejelava, J; Jelinskas, A; Jenni, P; Jeske, C; Jézéquel, S; Ji, H; Jia, J; Jiang, H; Jiang, Y; Jiang, Z; Jiggins, S; Jimenez Pena, J; Jin, S; Jinaru, A; Jinnouchi, O; Jivan, H; Johansson, P; Johns, K A; Johnson, C A; Johnson, W J; Jon-And, K; Jones, R W L; Jones, S D; Jones, S; Jones, T J; Jongmanns, J; Jorge, P M; Jovicevic, J; Ju, X; Rozas, A Juste; Köhler, M K; Kaczmarska, A; Kado, M; Kagan, H; Kagan, M; Kahn, S J; Kaji, T; Kajomovitz, E; Kalderon, C W; Kaluza, A; Kama, S; Kamenshchikov, A; Kanaya, N; Kanjir, L; Kantserov, V A; Kanzaki, J; Kaplan, B; Kaplan, L S; Kar, D; Karakostas, K; Karastathis, N; Kareem, M J; Karentzos, E; Karpov, S N; Karpova, Z M; Karthik, K; Kartvelishvili, V; Karyukhin, A N; Kasahara, K; Kashif, L; Kass, R D; Kastanas, A; Kataoka, Y; Kato, C; Katre, A; Katzy, J; Kawade, K; Kawagoe, K; Kawamoto, T; Kawamura, G; Kay, E F; Kazanin, V F; Keeler, R; Kehoe, R; Keller, J S; Kempster, J J; Kendrick, J; Keoshkerian, H; Kepka, O; Kerševan, B P; Kersten, S; Keyes, R A; Khader, M; Khalil-Zada, F; Khanov, A; Kharlamov, A G; Kharlamova, T; Khodinov, A; Khoo, T J; Khovanskiy, V; Khramov, E; Khubua, J; Kido, S; Kilby, C R; Kim, H Y; Kim, S H; Kim, Y K; Kimura, N; Kind, O M; King, B T; Kirchmeier, D; Kirk, J; Kiryunin, A E; Kishimoto, T; Kisielewska, D; Kitali, V; Kiuchi, K; Kivernyk, O; Kladiva, E; Klapdor-Kleingrothaus, T; Klein, M H; Klein, M; Klein, U; Kleinknecht, K; Klimek, P; Klimentov, A; Klingenberg, R; Klingl, T; Klioutchnikova, T; Kluge, E-E; Kluit, P; Kluth, S; Kneringer, E; Knoops, E B F G; Knue, A; Kobayashi, A; Kobayashi, D; Kobayashi, T; Kobel, M; Kocian, M; Kodys, P; Koffas, T; Koffeman, E; Köhler, N M; Koi, T; Kolb, M; Koletsou, I; Komar, A A; Komori, Y; Kondo, T; Kondrashova, N; Köneke, K; König, A C; Kono, T; Konoplich, R; Konstantinidis, N; Kopeliansky, R; Koperny, S; Kopp, A K; Korcyl, K; Kordas, K; Korn, A; Korol, A A; Korolkov, I; Korolkova, E V; Kortner, O; Kortner, S; Kosek, T; Kostyukhin, V V; Kotwal, A; Koulouris, A; Kourkoumeli-Charalampidi, A; Kourkoumelis, C; Kourlitis, E; Kouskoura, V; Kowalewska, A B; Kowalewski, R; Kowalski, T Z; Kozakai, C; Kozanecki, W; Kozhin, A S; Kramarenko, V A; Kramberger, G; Krasnopevtsev, D; Krasny, M W; Krasznahorkay, A; Krauss, D; Kremer, J A; Kretzschmar, J; Kreutzfeldt, K; Krieger, P; Krizka, K; Kroeninger, K; Kroha, H; Kroll, J; Kroll, J; Kroseberg, J; Krstic, J; Kruchonak, U; Krüger, H; Krumnack, N; Kruse, M C; Kubota, T; Kucuk, H; Kuday, S; Kuechler, J T; Kuehn, S; Kugel, A; Kuger, F; Kuhl, T; Kukhtin, V; Kukla, R; Kulchitsky, Y; Kuleshov, S; Kulinich, Y P; Kuna, M; Kunigo, T; Kupco, A; Kupfer, T; Kuprash, O; Kurashige, H; Kurchaninov, L L; Kurochkin, Y A; Kurth, M G; Kus, V; Kuwertz, E S; Kuze, M; Kvita, J; Kwan, T; Kyriazopoulos, D; La Rosa, A; La Rosa Navarro, J L; La Rotonda, L; Lacasta, C; Lacava, F; Lacey, J; Lacker, H; Lacour, D; Ladygin, E; Lafaye, R; Laforge, B; Lagouri, T; Lai, S; Lammers, S; Lampl, W; Lançon, E; Landgraf, U; Landon, M P J; Lanfermann, M C; Lang, V S; Lange, J C; Langenberg, R J; Lankford, A J; Lanni, F; Lantzsch, K; Lanza, A; Lapertosa, A; Laplace, S; Laporte, J F; Lari, T; Manghi, F Lasagni; Lassnig, M; Laurelli, P; Lavrijsen, W; Law, A T; Laycock, P; Lazovich, T; Lazzaroni, M; Le, B; Le Dortz, O; Le Guirriec, E; Le Quilleuc, E P; LeBlanc, M; LeCompte, T; Ledroit-Guillon, F; Lee, C A; Lee, G R; Lee, S C; Lee, L; Lefebvre, B; Lefebvre, G; Lefebvre, M; Legger, F; Leggett, C; Lehan, A; Lehmann Miotto, G; Lei, X; Leight, W A; Leite, M A L; Leitner, R; Lellouch, D; Lemmer, B; Leney, K J C; Lenz, T; Lenzi, B; Leone, R; Leone, S; Leonidopoulos, C; Lerner, G; Leroy, C; Lesage, A A J; Lester, C G; Levchenko, M; Levêque, J; Levin, D; Levinson, L J; Levy, M; Lewis, D; Li, B; Li, H; Li, L; Li, Q; Li, S; Li, X; Li, Y; Liang, Z; Liberti, B; Liblong, A; Lie, K; Liebal, J; Liebig, W; Limosani, A; Lin, S C; Lin, T H; Lindquist, B E; Lionti, A E; Lipeles, E; Lipniacka, A; Lisovyi, M; Liss, T M; Lister, A; Litke, A M; Liu, B; Liu, H; Liu, H; Liu, J K K; Liu, J; Liu, J B; Liu, K; Liu, L; Liu, M; Liu, Y L; Liu, Y; Livan, M; Lleres, A; Llorente Merino, J; Lloyd, S L; Lo, C Y; Sterzo, F Lo; Lobodzinska, E M; Loch, P; Loebinger, F K; Loesle, A; Loew, K M; Loginov, A; Lohse, T; Lohwasser, K; Lokajicek, M; Long, B A; Long, J D; Long, R E; Longo, L; Looper, K A; Lopez, J A; Lopez Mateos, D; Lopez Paz, I; Solis, A Lopez; Lorenz, J; Lorenzo Martinez, N; Losada, M; Lösel, P J; Lou, X; Lounis, A; Love, J; Love, P A; Lu, H; Lu, N; Lu, Y J; Lubatti, H J; Luci, C; Lucotte, A; Luedtke, C; Luehring, F; Lukas, W; Luminari, L; Lundberg, O; Lund-Jensen, B; Luzi, P M; Lynn, D; Lysak, R; Lytken, E; Lyubushkin, V; Ma, H; Ma, L L; Ma, Y; Maccarrone, G; Macchiolo, A; Macdonald, C M; Maček, B; Machado Miguens, J; Madaffari, D; Madar, R; Mader, W F; Madsen, A; Maeda, J; Maeland, S; Maeno, T; Maevskiy, A S; Magerl, V; Mahlstedt, J; Maiani, C; Maidantchik, C; Maier, A A; Maier, T; Maio, A; Majersky, O; Majewski, S; Makida, Y; Makovec, N; Malaescu, B; Malecki, Pa; Maleev, V P; Malek, F; Mallik, U; Malon, D; Malone, C; Maltezos, S; Malyukov, S; Mamuzic, J; Mancini, G; Mandelli, L; Mandić, I; Maneira, J; Manhaes de Andrade Filho, L; Manjarres Ramos, J; Mann, A; Manousos, A; Mansoulie, B; Mansour, J D; Mantifel, R; Mantoani, M; Manzoni, S; Mapelli, L; Marceca, G; March, L; Marchese, L; Marchiori, G; Marcisovsky, M; Marjanovic, M; Marley, D E; Marroquim, F; Marsden, S P; Marshall, Z; Martensson, M U F; Marti-Garcia, S; Martin, C B; Martin, T A; Martin, V J; Martin Dit Latour, B; Martinez, M; Martinez Outschoorn, V I; Martin-Haugh, S; Martoiu, V S; Martyniuk, A C; Marzin, A; Masetti, L; Mashimo, T; Mashinistov, R; Masik, J; Maslennikov, A L; Massa, L; Mastrandrea, P; Mastroberardino, A; Masubuchi, T; Mättig, P; Maurer, J; Maxfield, S J; Maximov, D A; Mazini, R; Maznas, I; Mazza, S M; Mc Fadden, N C; Goldrick, G Mc; Mc Kee, S P; McCarn, A; McCarthy, R L; McCarthy, T G; McClymont, L I; McDonald, E F; Mcfayden, J A; Mchedlidze, G; McMahon, S J; McNamara, P C; McPherson, R A; Meehan, S; Megy, T J; Mehlhase, S; Mehta, A; Meideck, T; Meier, K; Meirose, B; Melini, D; Mellado Garcia, B R; Mellenthin, J D; Melo, M; Meloni, F; Menary, S B; Meng, L; Meng, X T; Mengarelli, A; Menke, S; Meoni, E; Mergelmeyer, S; Mermod, P; Merola, L; Meroni, C; Merritt, F S; Messina, A; Metcalfe, J; Mete, A S; Meyer, C; Meyer, J-P; Meyer, J; Meyer Zu Theenhausen, H; Miano, F; Middleton, R P; Miglioranzi, S; Mijović, L; Mikenberg, G; Mikestikova, M; Mikuž, M; Milesi, M; Milic, A; Miller, D W; Mills, C; Milov, A; Milstead, D A; Minaenko, A A; Minami, Y; Minashvili, I A; Mincer, A I; Mindur, B; Mineev, M; Minegishi, Y; Ming, Y; Mir, L M; Mistry, K P; Mitani, T; Mitrevski, J; Mitsou, V A; Miucci, A; Miyagawa, P S; Mizukami, A; Mjörnmark, J U; Mkrtchyan, T; Mlynarikova, M; Moa, T; Mochizuki, K; Mogg, P; Mohapatra, S; Molander, S; Moles-Valls, R; Monden, R; Mondragon, M C; Mönig, K; Monk, J; Monnier, E; Montalbano, A; Montejo Berlingen, J; Monticelli, F; Monzani, S; Moore, R W; Morange, N; Moreno, D; Moreno Llácer, M; Morettini, P; Morgenstern, S; Mori, D; Mori, T; Morii, M; Morinaga, M; Morisbak, V; Morley, A K; Mornacchi, G; Morris, J D; Morvaj, L; Moschovakos, P; Mosidze, M; Moss, H J; Moss, J; Motohashi, K; Mount, R; Mountricha, E; Moyse, E J W; Muanza, S; Mudd, R D; Mueller, F; Mueller, J; Mueller, R S P; Muenstermann, D; Mullen, P; Mullier, G A; Munoz Sanchez, F J; Murray, W J; Musheghyan, H; Muškinja, M; Myagkov, A G; Myska, M; Nachman, B P; Nackenhorst, O; Nagai, K; Nagai, R; Nagano, K; Nagasaka, Y; Nagata, K; Nagel, M; Nagy, E; Nairz, A M; Nakahama, Y; Nakamura, K; Nakamura, T; Nakano, I; Naranjo Garcia, R F; Narayan, R; Narrias Villar, D I; Naryshkin, I; Naumann, T; Navarro, G; Nayyar, R; Neal, H A; Nechaeva, P Yu; Neep, T J; Negri, A; Negrini, M; Nektarijevic, S; Nellist, C; Nelson, A; Nelson, M E; Nemecek, S; Nemethy, P; Nessi, M; Neubauer, M S; Neumann, M; Newman, P R; Ng, T Y; Nguyen Manh, T; Nickerson, R B; Nicolaidou, R; Nielsen, J; Nikolaenko, V; Nikolic-Audit, I; Nikolopoulos, K; Nilsen, J K; Nilsson, P; Ninomiya, Y; Nisati, A; Nishu, N; Nisius, R; Nitsche, I; Nobe, T; Noguchi, Y; Nomachi, M; Nomidis, I; Nomura, M A; Nooney, T; Nordberg, M; Norjoharuddeen, N; Novgorodova, O; Nowak, S; Nozaki, M; Nozka, L; Ntekas, K; Nurse, E; Nuti, F; O'connor, K; O'Neil, D C; O'Rourke, A A; O'Shea, V; Oakham, F G; Oberlack, H; Obermann, T; Ocariz, J; Ochi, A; Ochoa, I; Ochoa-Ricoux, J P; Oda, S; Odaka, S; Ogren, H; Oh, A; Oh, S H; Ohm, C C; Ohman, H; Oide, H; Okawa, H; Okumura, Y; Okuyama, T; Olariu, A; Oleiro Seabra, L F; Olivares Pino, S A; Oliveira Damazio, D; Olszewski, A; Olszowska, J; Onofre, A; Onogi, K; Onyisi, P U E; Oppen, H; Oreglia, M J; Oren, Y; Orestano, D; Orlando, N; Orr, R S; Osculati, B; Ospanov, R; Otero Y Garzon, G; Otono, H; Ouchrif, M; Ould-Saada, F; Ouraou, A; Oussoren, K P; Ouyang, Q; Owen, M; Owen, R E; Ozcan, V E; Ozturk, N; Pachal, K; Pacheco Pages, A; Pacheco Rodriguez, L; Padilla Aranda, C; Pagan Griso, S; Paganini, M; Paige, F; Palacino, G; Palazzo, S; Palestini, S; Palka, M; Pallin, D; Panagiotopoulou, E St; Panagoulias, I; Pandini, C E; Panduro Vazquez, J G; Pani, P; Panitkin, S; Pantea, D; Paolozzi, L; Papadopoulou, Th D; Papageorgiou, K; Paramonov, A; Paredes Hernandez, D; Parker, A J; Parker, M A; Parker, K A; Parodi, F; Parsons, J A; Parzefall, U; Pascuzzi, V R; Pasner, J M; Pasqualucci, E; Passaggio, S; Pastore, Fr; Pataraia, S; Pater, J R; Pauly, T; Pearson, B; Pedraza Lopez, S; Pedro, R; Peleganchuk, S V; Penc, O; Peng, C; Peng, H; Penwell, J; Peralva, B S; Perego, M M; Perepelitsa, D V; Perini, L; Pernegger, H; Perrella, S; Peschke, R; Peshekhonov, V D; Peters, K; Peters, R F Y; Petersen, B A; Petersen, T C; Petit, E; Petridis, A; Petridou, C; Petroff, P; Petrolo, E; Petrov, M; Petrucci, F; Pettersson, N E; Peyaud, A; Pezoa, R; Phillips, F H; Phillips, P W; Piacquadio, G; Pianori, E; Picazio, A; Piccaro, E; Pickering, M A; Piegaia, R; Pilcher, J E; Pilkington, A D; Pin, A W J; Pinamonti, M; Pinfold, J L; Pirumov, H; Pitt, M; Plazak, L; Pleier, M-A; Pleskot, V; Plotnikova, E; Pluth, D; Podberezko, P; Poettgen, R; Poggi, R; Poggioli, L; Pohl, D; Polesello, G; Poley, A; Policicchio, A; Polifka, R; Polini, A; Pollard, C S; Polychronakos, V; Pommès, K; Ponomarenko, D; Pontecorvo, L; Pope, B G; Popeneciu, G A; Poppleton, A; Pospisil, S; Potamianos, K; Potrap, I N; Potter, C J; Poulard, G; Poulsen, T; Poveda, J; Pozo Astigarraga, M E; Pralavorio, P; Pranko, A; Prell, S; Price, D; Price, L E; Primavera, M; Prince, S; Proklova, N; Prokofiev, K; Prokoshin, F; Protopopescu, S; Proudfoot, J; Przybycien, M; Puri, A; Puzo, P; Qian, J; Qin, G; Qin, Y; Quadt, A; Queitsch-Maitland, M; Quilty, D; Raddum, S; Radeka, V; Radescu, V; Radhakrishnan, S K; Radloff, P; Rados, P; Ragusa, F; Rahal, G; Raine, J A; Rajagopalan, S; Rangel-Smith, C; Rashid, T; Raspopov, S; Ratti, M G; Rauch, D M; Rauscher, F; Rave, S; Ravinovich, I; Rawling, J H; Raymond, M; Read, A L; Readioff, N P; Reale, M; Rebuzzi, D M; Redelbach, A; Redlinger, G; Reece, R; Reed, R G; Reeves, K; Rehnisch, L; Reichert, J; Reiss, A; Rembser, C; Ren, H; Rescigno, M; Resconi, S; Resseguie, E D; Rettie, S; Reynolds, E; Rezanova, O L; Reznicek, P; Rezvani, R; Richter, R; Richter, S; Richter-Was, E; Ricken, O; Ridel, M; Rieck, P; Riegel, C J; Rieger, J; Rifki, O; Rijssenbeek, M; Rimoldi, A; Rimoldi, M; Rinaldi, L; Ripellino, G; Ristić, B; Ritsch, E; Riu, I; Rizatdinova, F; Rizvi, E; Rizzi, C; Roberts, R T; Robertson, S H; Robichaud-Veronneau, A; Robinson, D; Robinson, J E M; Robson, A; Rocco, E; Roda, C; Rodina, Y; Rodriguez Bosca, S; Rodriguez Perez, A; Rodriguez Rodriguez, D; Roe, S; Rogan, C S; Røhne, O; Roloff, J; Romaniouk, A; Romano, M; Romano Saez, S M; Romero Adam, E; Rompotis, N; Ronzani, M; Roos, L; Rosati, S; Rosbach, K; Rose, P; Rosien, N-A; Rossi, E; Rossi, L P; Rosten, J H N; Rosten, R; Rotaru, M; Roth, I; Rothberg, J; Rousseau, D; Rozanov, A; Rozen, Y; Ruan, X; Rubbo, F; Rühr, F; Ruiz-Martinez, A; Rurikova, Z; Rusakovich, N A; Russell, H L; Rutherfoord, J P; Ruthmann, N; Ryabov, Y F; Rybar, M; Rybkin, G; Ryu, S; Ryzhov, A; Rzehorz, G F; Saavedra, A F; Sabato, G; Sacerdoti, S; Sadrozinski, H F-W; Sadykov, R; Safai Tehrani, F; Saha, P; Sahinsoy, M; Saimpert, M; Saito, M; Saito, T; Sakamoto, H; Sakurai, Y; Salamanna, G; Salazar Loyola, J E; Salek, D; De Bruin, P H Sales; Salihagic, D; Salnikov, A; Salt, J; Salvatore, D; Salvatore, F; Salvucci, A; Salzburger, A; Sammel, D; Sampsonidis, D; Sampsonidou, D; Sánchez, J; Sanchez Martinez, V; Sanchez Pineda, A; Sandaker, H; Sandbach, R L; Sander, C O; Sandhoff, M; Sandoval, C; Sankey, D P C; Sannino, M; Sansoni, A; Santoni, C; Santonico, R; Santos, H; Santoyo Castillo, I; Sapronov, A; Saraiva, J G; Sarrazin, B; Sasaki, O; Sato, K; Sauvan, E; Savage, G; Savard, P; Savic, N; Sawyer, C; Sawyer, L; Saxon, J; Sbarra, C; Sbrizzi, A; Scanlon, T; Scannicchio, D A; Scarcella, M; Scarfone, V; Schaarschmidt, J; Schacht, P; Schachtner, B M; Schaefer, D; Schaefer, L; Schaefer, R; Schaeffer, J; Schaepe, S; Schaetzel, S; Schäfer, U; Schaffer, A C; Schaile, D; Schamberger, R D; Scharf, V; Schegelsky, V A; Scheirich, D; Schernau, M; Schiavi, C; Schier, S; Schildgen, L K; Schillo, C; Schioppa, M; Schlenker, S; Schmidt-Sommerfeld, K R; Schmieden, K; Schmitt, C; Schmitt, S; Schmitz, S; Schnoor, U; Schoeffel, L; Schoening, A; Schoenrock, B D; Schopf, E; Schott, M; Schouwenberg, J F P; Schovancova, J; Schramm, S; Schuh, N; Schulte, A; Schultens, M J; Schultz-Coulon, H-C; Schulz, H; Schumacher, M; Schumm, B A; Schune, Ph; Schwartzman, A; Schwarz, T A; Schweiger, H; Schwemling, Ph; Schwienhorst, R; Schwindling, J; Sciandra, A; Sciolla, G; Scuri, F; Scutti, F; Searcy, J; Seema, P; Seidel, S C; Seiden, A; Seixas, J M; Sekhniaidze, G; Sekhon, K; Sekula, S J; Semprini-Cesari, N; Senkin, S; Serfon, C; Serin, L; Serkin, L; Sessa, M; Seuster, R; Severini, H; Sfiligoj, T; Sforza, F; Sfyrla, A; Shabalina, E; Shaikh, N W; Shan, L Y; Shang, R; Shank, J T; Shapiro, M; Shatalov, P B; Shaw, K; Shaw, S M; Shcherbakova, A; Shehu, C Y; Shen, Y; Sherafati, N; Sherwood, P; Shi, L; Shimizu, S; Shimmin, C O; Shimojima, M; Shipsey, I P J; Shirabe, S; Shiyakova, M; Shlomi, J; Shmeleva, A; Shoaleh Saadi, D; Shochet, M J; Shojaii, S; Shope, D R; Shrestha, S; Shulga, E; Shupe, M A; Sicho, P; Sickles, A M; Sidebo, P E; Sideras Haddad, E; Sidiropoulou, O; Sidoti, A; Siegert, F; Sijacki, Dj; Silva, J; Silverstein, S B; Simak, V; Simic, Lj; Simion, S; Simioni, E; Simmons, B; Simon, M; Sinervo, P; Sinev, N B; Sioli, M; Siragusa, G; Siral, I; Sivoklokov, S Yu; Sjölin, J; Skinner, M B; Skubic, P; Slater, M; Slavicek, T; Slawinska, M; Sliwa, K; Slovak, R; Smakhtin, V; Smart, B H; Smiesko, J; Smirnov, N; Smirnov, S Yu; Smirnov, Y; Smirnova, L N; Smirnova, O; Smith, J W; Smith, M N K; Smith, R W; Smizanska, M; Smolek, K; Snesarev, A A; Snyder, I M; Snyder, S; Sobie, R; Socher, F; Soffer, A; Søgaard, A; Soh, D A; Sokhrannyi, G; Solans Sanchez, C A; Solar, M; Soldatov, E Yu; Soldevila, U; Solodkov, A A; Soloshenko, A; Solovyanov, O V; Solovyev, V; Sommer, P; Son, H; Sopczak, A; Sosa, D; Sotiropoulou, C L; Soualah, R; Soukharev, A M; South, D; Sowden, B C; Spagnolo, S; Spalla, M; Spangenberg, M; Spanò, F; Sperlich, D; Spettel, F; Spieker, T M; Spighi, R; Spigo, G; Spiller, L A; Spousta, M; St Denis, R D; Stabile, A; Stamen, R; Stamm, S; Stanecka, E; Stanek, R W; Stanescu, C; Stanitzki, M M; Stapf, B S; Stapnes, S; Starchenko, E A; Stark, G H; Stark, J; Stark, S H; Staroba, P; Starovoitov, P; Stärz, S; Staszewski, R; Steinberg, P; Stelzer, B; Stelzer, H J; Stelzer-Chilton, O; Stenzel, H; Stewart, G A; Stockton, M C; Stoebe, M; Stoicea, G; Stolte, P; Stonjek, S; Stradling, A R; Straessner, A; Stramaglia, M E; Strandberg, J; Strandberg, S; Strauss, M; Strizenec, P; Ströhmer, R; Strom, D M; Stroynowski, R; Strubig, A; Stucci, S A; Stugu, B; Styles, N A; Su, D; Su, J; Suchek, S; Sugaya, Y; Suk, M; Sulin, V V; Sultan, Dms; Sultansoy, S; Sumida, T; Sun, S; Sun, X; Suruliz, K; Suster, C J E; Sutton, M R; Suzuki, S; Svatos, M; Swiatlowski, M; Swift, S P; Sykora, I; Sykora, T; Ta, D; Tackmann, K; Taenzer, J; Taffard, A; Tafirout, R; Tahirovic, E; Taiblum, N; Takai, H; Takashima, R; Takasugi, E H; Takeshita, T; Takubo, Y; Talby, M; Talyshev, A A; Tanaka, J; Tanaka, M; Tanaka, R; Tanaka, S; Tanioka, R; Tannenwald, B B; Tapia Araya, S; Tapprogge, S; Tarem, S; Tartarelli, G F; Tas, P; Tasevsky, M; Tashiro, T; Tassi, E; Tavares Delgado, A; Tayalati, Y; Taylor, A C; Taylor, G N; Taylor, P T E; Taylor, W; Teixeira-Dias, P; Temple, D; Ten Kate, H; Teng, P K; Teoh, J J; Tepel, F; Terada, S; Terashi, K; Terron, J; Terzo, S; Testa, M; Teuscher, R J; Theveneaux-Pelzer, T; Thomas, J P; Thomas-Wilsker, J; Thompson, P D; Thompson, A S; Thomsen, L A; Thomson, E; Tibbetts, M J; Ticse Torres, R E; Tikhomirov, V O; Tikhonov, Yu A; Timoshenko, S; Tipton, P; Tisserant, S; Todome, K; Todorova-Nova, S; Tojo, J; Tokár, S; Tokushuku, K; Tolley, E; Tomlinson, L; Tomoto, M; Tompkins, L; Toms, K; Tong, B; Tornambe, P; Torrence, E; Torres, H; Torró Pastor, E; Toth, J; Touchard, F; Tovey, D R; Treado, C J; Trefzger, T; Tresoldi, F; Tricoli, A; Trigger, I M; Trincaz-Duvoid, S; Tripiana, M F; Trischuk, W; Trocmé, B; Trofymov, A; Troncon, C; Trottier-McDonald, M; Trovatelli, M; Truong, L; Trzebinski, M; Trzupek, A; Tsang, K W; Tseng, J C-L; Tsiareshka, P V; Tsipolitis, G; Tsirintanis, N; Tsiskaridze, S; Tsiskaridze, V; Tskhadadze, E G; Tsui, K M; Tsukerman, I I; Tsulaia, V; Tsuno, S; Tsybychev, D; Tu, Y; Tudorache, A; Tudorache, V; Tulbure, T T; Tuna, A N; Tupputi, S A; Turchikhin, S; Turgeman, D; Turk Cakir, I; Turra, R; Tuts, P M; Ucchielli, G; Ueda, I; Ughetto, M; Ukegawa, F; Unal, G; Undrus, A; Unel, G; Ungaro, F C; Unno, Y; Unverdorben, C; Urban, J; Urquijo, P; Urrejola, P; Usai, G; Usui, J; Vacavant, L; Vacek, V; Vachon, B; Vadla, K O H; Vaidya, A; Valderanis, C; Valdes Santurio, E; Valente, M; Valentinetti, S; Valero, A; Valéry, L; Valkar, S; Vallier, A; Valls Ferrer, J A; Van Den Wollenberg, W; van der Graaf, H; van Gemmeren, P; Van Nieuwkoop, J; van Vulpen, I; van Woerden, M C; Vanadia, M; Vandelli, W; Vaniachine, A; Vankov, P; Vardanyan, G; Vari, R; Varnes, E W; Varni, C; Varol, T; Varouchas, D; Vartapetian, A; Varvell, K E; Vasquez, J G; Vasquez, G A; Vazeille, F; Vazquez Schroeder, T; Veatch, J; Veeraraghavan, V; Veloce, L M; Veloso, F; Veneziano, S; Ventura, A; Venturi, M; Venturi, N; Venturini, A; Vercesi, V; Verducci, M; Verkerke, W; Vermeulen, A T; Vermeulen, J C; Vetterli, M C; Viaux Maira, N; Viazlo, O; Vichou, I; Vickey, T; Vickey Boeriu, O E; Viehhauser, G H A; Viel, S; Vigani, L; Villa, M; Villaplana Perez, M; Vilucchi, E; Vincter, M G; Vinogradov, V B; Vishwakarma, A; Vittori, C; Vivarelli, I; Vlachos, S; Vlasak, M; Vogel, M; Vokac, P; Volpi, G; von der Schmitt, H; von Toerne, E; Vorobel, V; Vorobev, K; Vos, M; Voss, R; Vossebeld, J H; Vranjes, N; Vranjes Milosavljevic, M; Vrba, V; Vreeswijk, M; Vuillermet, R; Vukotic, I; Wagner, P; Wagner, W; Wagner-Kuhr, J; Wahlberg, H; Wahrmund, S; Wakabayashi, J; Walder, J; Walker, R; Walkowiak, W; Wallangen, V; Wang, C; Wang, C; Wang, F; Wang, H; Wang, H; Wang, J; Wang, J; Wang, Q; Wang, R; Wang, S M; Wang, T; Wang, W; Wang, W; Wang, Z; Wanotayaroj, C; Warburton, A; Ward, C P; Wardrope, D R; Washbrook, A; Watkins, P M; Watson, A T; Watson, M F; Watts, G; Watts, S; Waugh, B M; Webb, A F; Webb, S; Weber, M S; Weber, S W; Weber, S A; Webster, J S; Weidberg, A R; Weinert, B; Weingarten, J; Weirich, M; Weiser, C; Weits, H; Wells, P S; Wenaus, T; Wengler, T; Wenig, S; Wermes, N; Werner, M D; Werner, P; Wessels, M; Weston, T D; Whalen, K; Whallon, N L; Wharton, A M; White, A S; White, A; White, M J; White, R; Whiteson, D; Whitmore, B W; Wickens, F J; Wiedenmann, W; Wielers, M; Wiglesworth, C; Wiik-Fuchs, L A M; Wildauer, A; Wilk, F; Wilkens, H G; Williams, H H; Williams, S; Willis, C; Willocq, S; Wilson, J A; Wingerter-Seez, I; Winkels, E; Winklmeier, F; Winston, O J; Winter, B T; Wittgen, M; Wobisch, M; Wolf, T M H; Wolff, R; Wolter, M W; Wolters, H; Wong, V W S; Worm, S D; Wosiek, B K; Wotschack, J; Wozniak, K W; Wu, M; Wu, S L; Wu, X; Wu, Y; Wyatt, T R; Wynne, B M; Xella, S; Xi, Z; Xia, L; Xu, D; Xu, L; Yabsley, B; Yacoob, S; Yamaguchi, D; Yamaguchi, Y; Yamamoto, A; Yamamoto, S; Yamanaka, T; Yamatani, M; Yamauchi, K; Yamazaki, Y; Yan, Z; Yang, H; Yang, H; Yang, Y; Yang, Z; Yao, W-M; Yap, Y C; Yasu, Y; Yatsenko, E; Yau Wong, K H; Ye, J; Ye, S; Yeletskikh, I; Yigitbasi, E; Yildirim, E; Yorita, K; Yoshihara, K; Young, C; Young, C J S; Yu, J; Yu, J; Yuen, S P Y; Yusuff, I; Zabinski, B; Zacharis, G; Zaidan, R; Zaitsev, A M; Zakharchuk, N; Zalieckas, J; Zaman, A; Zambito, S; Zanzi, D; Zeitnitz, C; Zemaityte, G; Zemla, A; Zeng, J C; Zeng, Q; Zenin, O; Ženiš, T; Zerwas, D; Zhang, D; Zhang, F; Zhang, G; Zhang, H; Zhang, J; Zhang, L; Zhang, L; Zhang, M; Zhang, P; Zhang, R; Zhang, R; Zhang, X; Zhang, Y; Zhang, Z; Zhao, X; Zhao, Y; Zhao, Z; Zhemchugov, A; Zhou, B; Zhou, C; Zhou, L; Zhou, M; Zhou, M; Zhou, N; Zhu, C G; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zibell, A; Zieminska, D; Zimine, N I; Zimmermann, C; Zimmermann, S; Zinonos, Z; Zinser, M; Ziolkowski, M; Živković, L; Zobernig, G; Zoccoli, A; Zou, R; Zur Nedden, M; Zwalinski, L

2017-01-01

With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 [Formula: see text] for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.2 fb[Formula: see text] of data collected by the ATLAS experiment and simulation of proton-proton collisions producing high-transverse-momentum jets at a centre-of-mass energy of 13 [Formula: see text]. The impact of charged-particle separations and multiplicities on the track reconstruction performance is discussed. The track reconstruction efficiency in the cores of jets with transverse momenta between 200 and 1600 [Formula: see text] is quantified using a novel, data-driven, method. The method uses the energy loss, [Formula: see text], to identify pixel clusters originating from two charged particles. Of the charged particles creating these clusters, the measured fraction that fail to be reconstructed is [Formula: see text] and [Formula: see text] for jet transverse momenta of 200-400 [Formula: see text] and 1400-1600 [Formula: see text], respectively.

Rosin-Rammler Distributions in ANSYS Fluent

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunham, Ryan Q.

In Health Physics monitoring, particles need to be collected and tracked. One method is to predict the motion of potential health hazards with computer models. Particles released from various sources within a glove box can become a respirable health hazard if released into the area surrounding a glove box. The goal of modeling the aerosols in a glove box is to reduce the hazards associated with a leak in the glove box system. ANSYS Fluent provides a number of tools for modeling this type of environment. Particles can be released using injections into the flow path with turbulent properties. Themore » models of particle tracks can then be used to predict paths and concentrations of particles within the flow. An attempt to understand and predict the handling of data by Fluent was made, and results iteratively tracked. Trends in data were studied to comprehend the final results. The purpose of the study was to allow a better understanding of the operation of Fluent for aerosol modeling for future application in many fields.« less

Electrically tunable lens speeds up 3D orbital tracking

PubMed Central

Annibale, Paolo; Dvornikov, Alexander; Gratton, Enrico

2015-01-01

3D orbital particle tracking is a versatile and effective microscopy technique that allows following fast moving fluorescent objects within living cells and reconstructing complex 3D shapes using laser scanning microscopes. We demonstrated notable improvements in the range, speed and accuracy of 3D orbital particle tracking by replacing commonly used piezoelectric stages with Electrically Tunable Lens (ETL) that eliminates mechanical movement of objective lenses. This allowed tracking and reconstructing shape of structures extending 500 microns in the axial direction. Using the ETL, we tracked at high speed fluorescently labeled genomic loci within the nucleus of living cells with unprecedented temporal resolution of 8ms using a 1.42NA oil-immersion objective. The presented technology is cost effective and allows easy upgrade of scanning microscopes for fast 3D orbital tracking. PMID:26114037

Precise 3D Track Reconstruction Algorithm for the ICARUS T600 Liquid Argon Time Projection Chamber Detector

DOE PAGES

Antonello, M.; Baibussinov, B.; Benetti, P.; ...

2013-01-15

Liquid Argon Time Projection Chamber (LAr TPC) detectors offer charged particle imaging capability with remarkable spatial resolution. Precise event reconstruction procedures are critical in order to fully exploit the potential of this technology. In this paper we present a new, general approach to 3D reconstruction for the LAr TPC with a practical application to the track reconstruction. The efficiency of the method is evaluated on a sample of simulated tracks. We present also the application of the method to the analysis of stopping particle tracks collected during the ICARUS T600 detector operation with the CNGS neutrino beam.

Diffusion rate limitations in actin-based propulsion of hard and deformable particles.

PubMed

Dickinson, Richard B; Purich, Daniel L

2006-08-15

The mechanism by which actin polymerization propels intracellular vesicles and invasive microorganisms remains an open question. Several recent quantitative studies have examined propulsion of biomimetic particles such as polystyrene microspheres, phospholipid vesicles, and oil droplets. In addition to allowing quantitative measurement of parameters such as the dependence of particle speed on its size, these systems have also revealed characteristic behaviors such a saltatory motion of hard particles and oscillatory deformation of soft particles. Such measurements and observations provide tests for proposed mechanisms of actin-based motility. In the actoclampin filament end-tracking motor model, particle-surface-bound filament end-tracking proteins are involved in load-insensitive processive insertion of actin subunits onto elongating filament plus-ends that are persistently tethered to the surface. In contrast, the tethered-ratchet model assumes working filaments are untethered and the free-ended filaments grow as thermal ratchets in a load-sensitive manner. This article presents a model for the diffusion and consumption of actin monomers during actin-based particle propulsion to predict the monomer concentration field around motile particles. The results suggest that the various behaviors of biomimetic particles, including dynamic saltatory motion of hard particles and oscillatory vesicle deformations, can be quantitatively and self-consistently explained by load-insensitive, diffusion-limited elongation of (+)-end-tethered actin filaments, consistent with predictions of the actoclampin filament-end tracking mechanism.

Synthesis of Brushite Particles in Reverse Microemulsions of the Biosurfactant Surfactin

PubMed Central

Maity, Jyoti Prakash; Lin, Tz-Jiun; Cheng, Henry Pai-Heng; Chen, Chien-Yen; Reddy, A. Satyanarayana; Atla, Shashi B.; Chang, Young-Fo; Chen, Hau-Ren; Chen, Chien-Cheng

2011-01-01

In this study the “green chemistry” use of the biosurfactant surfactin for the synthesis of calcium phosphate using the reverse microemulsion technique was demonstrated. Calcium phosphates are bioactive materials that are a major constituent of human teeth and bone tissue. A reverse microemulsion technique with surfactin was used to produce nanocrystalline brushite particles. Structural diversity (analyzed by SEM and TEM) resulted from different water to surfactin ratios (W/S; 250, 500, 1000 and 40,000). The particle sizes were found to be in the 16–200 nm range. Morphological variety was observed in the as-synthesized microemulsions, which consisted of nanospheres (~16 nm in diameter) and needle-like (8–14 nm in diameter and 80–100 nm in length) noncalcinated particles. However, the calcinated products included nanospheres (50–200 nm in diameter), oval (~300 nm in diameter) and nanorod (200–400 nm in length) particles. FTIR and XRD analysis confirmed the formation of brushite nanoparticles in the as-synthesized products, while calcium pyrophosphate was produced after calcination. These results indicate that the reverse microemulsion technique using surfactin is a green process suitable for the synthesis of nanoparticles. PMID:21747709

Polymer ligand–induced autonomous sorting and reversible phase separation in binary particle blends

DOE PAGES

Schmitt, Michael; Zhang, Jianan; Lee, Jaejun; ...

2016-12-23

The tethering of ligands to nanoparticles has emerged as an important strategy to control interactions and organization in particle assembly structures. Here, we demonstrate that ligand interactions in mixtures of polymer-tethered nanoparticles (which are modified with distinct types of polymer chains) can impart upper or lower critical solution temperature (UCST/LCST)–type phase behavior on binary particle mixtures in analogy to the phase behavior of the corresponding linear polymer blends. Therefore, cooling (or heating) of polymer-tethered particle blends with appropriate architecture to temperatures below (or above) the UCST (or LCST) results in the organization of the individual particle constituents into monotype microdomainmore » structures. The shape (bicontinuous or island-type) and lengthscale of particle microdomains can be tuned by variation of the composition and thermal process conditions. Thermal cycling of LCST particle brush blends through the critical temperature enables the reversible growth and dissolution of monoparticle domain structures. The ability to autonomously and reversibly organize multicomponent particle mixtures into monotype microdomain structures could enable transformative advances in the high-throughput fabrication of solid films with tailored and mutable structures and properties that play an important role in a range of nanoparticle-based material technologies.« less

Polymer ligand–induced autonomous sorting and reversible phase separation in binary particle blends

PubMed Central

Schmitt, Michael; Zhang, Jianan; Lee, Jaejun; Lee, Bongjoon; Ning, Xin; Zhang, Ren; Karim, Alamgir; Davis, Robert F.; Matyjaszewski, Krzysztof; Bockstaller, Michael R.

2016-01-01

The tethering of ligands to nanoparticles has emerged as an important strategy to control interactions and organization in particle assembly structures. We demonstrate that ligand interactions in mixtures of polymer-tethered nanoparticles (which are modified with distinct types of polymer chains) can impart upper or lower critical solution temperature (UCST/LCST)–type phase behavior on binary particle mixtures in analogy to the phase behavior of the corresponding linear polymer blends. Therefore, cooling (or heating) of polymer-tethered particle blends with appropriate architecture to temperatures below (or above) the UCST (or LCST) results in the organization of the individual particle constituents into monotype microdomain structures. The shape (bicontinuous or island-type) and lengthscale of particle microdomains can be tuned by variation of the composition and thermal process conditions. Thermal cycling of LCST particle brush blends through the critical temperature enables the reversible growth and dissolution of monoparticle domain structures. The ability to autonomously and reversibly organize multicomponent particle mixtures into monotype microdomain structures could enable transformative advances in the high-throughput fabrication of solid films with tailored and mutable structures and properties that play an important role in a range of nanoparticle-based material technologies. PMID:28028538

Mobile Timekeeping Application Built on Reverse-Engineered JPL Infrastructure

NASA Technical Reports Server (NTRS)

Witoff, Robert J.

2013-01-01

Every year, non-exempt employees cumulatively waste over one man-year tracking their time and using the timekeeping Web page to save those times. This app eliminates this waste. The innovation is a native iPhone app. Libraries were built around a reverse- engineered JPL API. It represents a punch-in/punch-out paradigm for timekeeping. It is accessible natively via iPhones, and features ease of access. Any non-exempt employee can natively punch in and out, as well as save and view their JPL timecard. This app is built on custom libraries created by reverse-engineering the standard timekeeping application. Communication is through custom libraries that re-route traffic through BrowserRAS (remote access service). This has value at any center where employees track their time.

A Novel, Modified Reverse Controlled Antegrade and Retrograde Subintimal Tracking Technique for Bypassing the Calcified Proximal Cap of Coronary Total Occlusions

PubMed Central

Ochiai, Masahiko; Munehisa, Masato; Ootomo, Tatsushi

2017-01-01

Antegrade crossing is the most common approach to chronic total occlusions (CTOs). However, it is sometimes difficult to penetrate the proximal hard cap with guidewires, especially in the case of CTOs of anomalous coronary arteries because of a lack of support. Herein, we describe a novel, modified reverse controlled antegrade and retrograde subintimal tracking (CART) technique in which the dissection reentry was intentionally created in the proximal segment of the vessel, not within the occluded segment, using retrograde guidewire and the aid of an antegrade balloon. This technique facilitated retrograde crossing of CTOs by avoiding the proximal hard cap and may provide a viable option for patients in which conventional reverse CART is not possible. PMID:28529807

Evidence for the Packaging of Multiple Copies of Tf1 mRNA into Particles and the trans Priming of Reverse Transcription

PubMed Central

Haag, Amanda Leigh; Lin, Jia-Hwei; Levin, Henry L.

2000-01-01

Long terminal repeat (LTR)-containing retrotransposons and retroviruses are close relatives that possess similar mechanisms of reverse transcription. The particles of retroviruses package two copies of viral mRNA that both function as templates for the reverse transcription of the element. We studied the LTR-retrotransposon Tf1 of Schizosaccharomyces pombe to test whether multiple copies of transposon mRNA participate in the production of cDNA. Using the unique self-priming property of Tf1, we obtained evidence that multiple copies of Tf1 mRNA were packaged into virus-like particles. By coexpressing two distinct versions of Tf1, we found that the bulk of reverse transcription that was initiated on one mRNA template was subsequently transferred to others. In addition, the first 11 nucleotides of one mRNA were able to prime, in trans, the reverse transcription of another mRNA. PMID:10888658

An in-silico walker

NASA Astrophysics Data System (ADS)

Xiao, Qiran; Chen, Yanping; Bereau, Tristan; Shi, Yunfeng

2016-08-01

The paradox of biomimetic research is to perform bio-functionality, usually associated with sophisticated structures optimized by nature, with minimal structural complexity for the ease of fabrication. Here we show that a three-particle trimer can exhibit kinesin-like autonomous walk on a track via reactive molecular dynamics simulations. The autonomous motion is due to imbalanced transitions resulting from exothermic catalytic reactions, and the spatial asymmetry from the track. This molecular design can be realized by reproducing the particle-particle interactions in functionalized nano- or colloidal particles. Our results open up the possibility of fabricating bio-mimetic nano-systems in a minimalist approach.

Ultra-high-speed 3D astigmatic particle tracking velocimetry: application to particle-laden supersonic impinging jets

NASA Astrophysics Data System (ADS)

Buchmann, N. A.; Cierpka, C.; Kähler, C. J.; Soria, J.

2014-11-01

The paper demonstrates ultra-high-speed three-component, three-dimensional (3C3D) velocity measurements of micron-sized particles suspended in a supersonic impinging jet flow. Understanding the dynamics of individual particles in such flows is important for the design of particle impactors for drug delivery or cold gas dynamic spray processing. The underexpanded jet flow is produced via a converging nozzle, and micron-sized particles ( d p = 110 μm) are introduced into the gas flow. The supersonic jet impinges onto a flat surface, and the particle impact velocity and particle impact angle are studied for a range of flow conditions and impingement distances. The imaging system consists of an ultra-high-speed digital camera (Shimadzu HPV-1) capable of recording rates of up to 1 Mfps. Astigmatism particle tracking velocimetry (APTV) is used to measure the 3D particle position (Cierpka et al., Meas Sci Technol 21(045401):13, 2010) by coding the particle depth location in the 2D images by adding a cylindrical lens to the high-speed imaging system. Based on the reconstructed 3D particle positions, the particle trajectories are obtained via a higher-order tracking scheme that takes advantage of the high temporal resolution to increase robustness and accuracy of the measurement. It is shown that the particle velocity and impingement angle are affected by the gas flow in a manner depending on the nozzle pressure ratio and stand-off distance where higher pressure ratios and stand-off distances lead to higher impact velocities and larger impact angles.

A highly scalable particle tracking algorithm using partitioned global address space (PGAS) programming for extreme-scale turbulence simulations

NASA Astrophysics Data System (ADS)

Buaria, D.; Yeung, P. K.

2017-12-01

A new parallel algorithm utilizing a partitioned global address space (PGAS) programming model to achieve high scalability is reported for particle tracking in direct numerical simulations of turbulent fluid flow. The work is motivated by the desire to obtain Lagrangian information necessary for the study of turbulent dispersion at the largest problem sizes feasible on current and next-generation multi-petaflop supercomputers. A large population of fluid particles is distributed among parallel processes dynamically, based on instantaneous particle positions such that all of the interpolation information needed for each particle is available either locally on its host process or neighboring processes holding adjacent sub-domains of the velocity field. With cubic splines as the preferred interpolation method, the new algorithm is designed to minimize the need for communication, by transferring between adjacent processes only those spline coefficients determined to be necessary for specific particles. This transfer is implemented very efficiently as a one-sided communication, using Co-Array Fortran (CAF) features which facilitate small data movements between different local partitions of a large global array. The cost of monitoring transfer of particle properties between adjacent processes for particles migrating across sub-domain boundaries is found to be small. Detailed benchmarks are obtained on the Cray petascale supercomputer Blue Waters at the University of Illinois, Urbana-Champaign. For operations on the particles in a 81923 simulation (0.55 trillion grid points) on 262,144 Cray XE6 cores, the new algorithm is found to be orders of magnitude faster relative to a prior algorithm in which each particle is tracked by the same parallel process at all times. This large speedup reduces the additional cost of tracking of order 300 million particles to just over 50% of the cost of computing the Eulerian velocity field at this scale. Improving support of PGAS models on major compilers suggests that this algorithm will be of wider applicability on most upcoming supercomputers.

Accumulative Difference Image Protocol for Particle Tracking in Fluorescence Microscopy Tested in Mouse Lymphonodes

PubMed Central

Villa, Carlo E.; Caccia, Michele; Sironi, Laura; D'Alfonso, Laura; Collini, Maddalena; Rivolta, Ilaria; Miserocchi, Giuseppe; Gorletta, Tatiana; Zanoni, Ivan; Granucci, Francesca; Chirico, Giuseppe

2010-01-01

The basic research in cell biology and in medical sciences makes large use of imaging tools mainly based on confocal fluorescence and, more recently, on non-linear excitation microscopy. Substantially the aim is the recognition of selected targets in the image and their tracking in time. We have developed a particle tracking algorithm optimized for low signal/noise images with a minimum set of requirements on the target size and with no a priori knowledge of the type of motion. The image segmentation, based on a combination of size sensitive filters, does not rely on edge detection and is tailored for targets acquired at low resolution as in most of the in-vivo studies. The particle tracking is performed by building, from a stack of Accumulative Difference Images, a single 2D image in which the motion of the whole set of the particles is coded in time by a color level. This algorithm, tested here on solid-lipid nanoparticles diffusing within cells and on lymphocytes diffusing in lymphonodes, appears to be particularly useful for the cellular and the in-vivo microscopy image processing in which few a priori assumption on the type, the extent and the variability of particle motions, can be done. PMID:20808918

Accumulative difference image protocol for particle tracking in fluorescence microscopy tested in mouse lymphonodes.

PubMed

Villa, Carlo E; Caccia, Michele; Sironi, Laura; D'Alfonso, Laura; Collini, Maddalena; Rivolta, Ilaria; Miserocchi, Giuseppe; Gorletta, Tatiana; Zanoni, Ivan; Granucci, Francesca; Chirico, Giuseppe

2010-08-17

The basic research in cell biology and in medical sciences makes large use of imaging tools mainly based on confocal fluorescence and, more recently, on non-linear excitation microscopy. Substantially the aim is the recognition of selected targets in the image and their tracking in time. We have developed a particle tracking algorithm optimized for low signal/noise images with a minimum set of requirements on the target size and with no a priori knowledge of the type of motion. The image segmentation, based on a combination of size sensitive filters, does not rely on edge detection and is tailored for targets acquired at low resolution as in most of the in-vivo studies. The particle tracking is performed by building, from a stack of Accumulative Difference Images, a single 2D image in which the motion of the whole set of the particles is coded in time by a color level. This algorithm, tested here on solid-lipid nanoparticles diffusing within cells and on lymphocytes diffusing in lymphonodes, appears to be particularly useful for the cellular and the in-vivo microscopy image processing in which few a priori assumption on the type, the extent and the variability of particle motions, can be done.

Controlling alpha tracks registration in Makrofol DE 1-1 detector

NASA Astrophysics Data System (ADS)

Hassan, N. M.; Hanafy, M. S.; Naguib, A.; El-Saftawy, A. A.

2017-09-01

Makrofol DE 1-1 is a recent type of solid state nuclear track detectors could be used to measure radon concentration in the environment throughout the detection of α-particles emitted from radon decay. Thus, studying the physical parameters that control the formation of alpha tracks is vital for environmental radiation protection. Makrofol DE 1-1 polycarbonate detector was irradiated by α-particles of energies varied from 2 to 5 MeV emitted from the 241Am source of α-particle energy of 5.5 MeV. Then, the detector was etched in an optimum etching solution of mixed ethyl alcohol in KOH aqueous solution of (85% (Vol.) of 6 M KOH + 15% (Vol.) C2H5OH) at 50 °C for 3 h. Afterward, the bulk etch rate, etching sensitivity, and the registration efficiency of the detector, which control the tracks registration, were measured. The bulk etch rate of Makrofol detector was found to be 3.71 ± 0.71 μm h-1. The etching sensitivity and the detector registration efficiency were decreased exponentially with α-particles' energies following Bragg curve. A precise registration of α-particle was presented in this study. Therefore, Makrofol DE 1-1 can be applied as a radiation dosimeter as well as radon and thoron monitors.

Simulating variable source problems via post processing of individual particle tallies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bleuel, D.L.; Donahue, R.J.; Ludewigt, B.A.

2000-10-20

Monte Carlo is an extremely powerful method of simulating complex, three dimensional environments without excessive problem simplification. However, it is often time consuming to simulate models in which the source can be highly varied. Similarly difficult are optimization studies involving sources in which many input parameters are variable, such as particle energy, angle, and spatial distribution. Such studies are often approached using brute force methods or intelligent guesswork. One field in which these problems are often encountered is accelerator-driven Boron Neutron Capture Therapy (BNCT) for the treatment of cancers. Solving the reverse problem of determining the best neutron source formore » optimal BNCT treatment can be accomplished by separating the time-consuming particle-tracking process of a full Monte Carlo simulation from the calculation of the source weighting factors which is typically performed at the beginning of a Monte Carlo simulation. By post-processing these weighting factors on a recorded file of individual particle tally information, the effect of changing source variables can be realized in a matter of seconds, instead of requiring hours or days for additional complete simulations. By intelligent source biasing, any number of different source distributions can be calculated quickly from a single Monte Carlo simulation. The source description can be treated as variable and the effect of changing multiple interdependent source variables on the problem's solution can be determined. Though the focus of this study is on BNCT applications, this procedure may be applicable to any problem that involves a variable source.« less

Timepix Device Efficiency for Pattern Recognition of Tracks Generated by Ionizing Radiation

NASA Astrophysics Data System (ADS)

Leroy, Claude; Asbah, Nedaa; Gagnon, Louis-Guilaume; Larochelle, Jean-Simon; Pospisil, Stanislav; Soueid, Paul

2014-06-01

A hybrid silicon pixelated TIMEPIX detector (256 × 256 pixels with 55 μm pitch) operated in Time Over Threshold (TOT) mode was exposed to radioactive sources (241Am, 106Ru, 137Cs), protons and alpha-particles after Rutherford Backscattering on a thin gold foil of protons and alpha-particles beams delivered by the Tandem Accelerator of Montreal University. Measurements were also performed with different mixed radiation fields of heavy charged particles (protons and alpha-particles), photons and electrons produced by simultaneous exposure of TIMEPIX to the radioactive sources and to protons beams on top of the radioactive sources. All measurements were performed in vacuum. The TOT mode of operation has allowed the direct measurement of the energy deposited in each pixel. The efficiency of track recognition with this device was tested by comparing the experimental activities (determined from number of tracks measurements) of the radioactive sources with their expected activities. The efficiency of track recognition of incident protons and alpha-particles of different energies as a function of the incidence angle was measured. The operation of TIMEPIX in TOT mode has allowed a 3D mapping of the charge sharing effect in the whole volume of the silicon sensor. The effect of the bias voltage on charge sharing was investigated as the level of charge sharing is related to the local profile of the electric field in the sensor. The results of the present measurements demonstrate the TIMEPIX capability of differentiating between different types of particles species from mixed radiation fields and measuring their energy deposition. Single track analysis gives a good precision (significantly better than the 55 μm size of one detector pixel) on the coordinates of the impact point of protons interacting in the TIMEPIX silicon layer.

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels.

PubMed

Virtanen, Otto L J; Purohit, Ashvini; Brugnoni, Monia; Wöll, Dominik; Richtering, Walter

2016-09-08

Stimuli-sensitive poly(N-isopropylacrylamide) (PNIPAM) microgels have various prospective practical applications and uses in fundamental research. In this work, we use single particle tracking of fluorescently labeled PNIPAM microgels as a showcase for tuning microgel size by a rapid non-stirred precipitation polymerization procedure. This approach is well suited for prototyping new reaction compositions and conditions or for applications that do not require large amounts of product. Microgel synthesis, particle size and structure determination by dynamic and static light scattering are detailed in the protocol. It is shown that the addition of functional comonomers can have a large influence on the particle nucleation and structure. Single particle tracking by wide-field fluorescence microscopy allows for an investigation of the diffusion of labeled tracer microgels in a concentrated matrix of non-labeled microgels, a system not easily investigated by other methods such as dynamic light scattering.

On particle track detectors

NASA Technical Reports Server (NTRS)

Benton, E. V.; Gruhn, T. A.; Andrus, C. H.

1973-01-01

Aqueous sodium hydroxide is widely used to develop charged particle tracks in polycarbonate film, particularly Lexan. The chemical nature of the etching process for this system has been determined. A method employing ultra-violet absorbance was developed for monitoring the concentration of the etch products in solution. Using this method it was possible to study the formation of the etching solution saturated in etch products. It was found that the system super-saturates to a significant extent before precipitation occurs. It was also learned that the system approaches its equilibrium state rather slowly. It is felt that both these phenomena may be due to the presence of surfactant in the solution. In light of these findings, suggestions are given regarding the preparation and maintenance of the saturated etch solution. Two additional research projects, involving automated techniques for particle track analysis and particle identification using AgCl crystals, are briefly summarized.

A new method for evaluating radon and thoron alpha-activities per unit volume inside and outside various natural material samples by calculating SSNTD detection efficiencies for the emitted alpha-particles and measuring the resulting track densities.

PubMed

Misdaq, M A; Aitnouh, F; Khajmi, H; Ezzahery, H; Berrazzouk, S

2001-08-01

A Monte Carlo computer code for determining detection efficiencies of the CR-39 and LR-115 II solid-state nuclear track detectors (SSNTD) for alpha-particles emitted by the uranium and thorium series inside different natural material samples was developed. The influence of the alpha-particle initial energy on the SSNTD detection efficiencies was investigated. Radon (222Rn) and thoron (220Rn) alpha-activities per unit volume were evaluated inside and outside the natural material samples by exploiting data obtained for the detection efficiencies of the SSNTD utilized for the emitted alpha-particles, and measuring the resulting track densities. Results obtained were compared to those obtained by other methods. Radon emanation coefficients have been determined for some of the considered material samples.

Tracking of multiple targets using online learning for reference model adaptation.

PubMed

Pernkopf, Franz

2008-12-01

Recently, much work has been done in multiple object tracking on the one hand and on reference model adaptation for a single-object tracker on the other side. In this paper, we do both tracking of multiple objects (faces of people) in a meeting scenario and online learning to incrementally update the models of the tracked objects to account for appearance changes during tracking. Additionally, we automatically initialize and terminate tracking of individual objects based on low-level features, i.e., face color, face size, and object movement. Many methods unlike our approach assume that the target region has been initialized by hand in the first frame. For tracking, a particle filter is incorporated to propagate sample distributions over time. We discuss the close relationship between our implemented tracker based on particle filters and genetic algorithms. Numerous experiments on meeting data demonstrate the capabilities of our tracking approach. Additionally, we provide an empirical verification of the reference model learning during tracking of indoor and outdoor scenes which supports a more robust tracking. Therefore, we report the average of the standard deviation of the trajectories over numerous tracking runs depending on the learning rate.

Collective ratchet effects and reversals for active matter particles on quasi-one-dimensional asymmetric substrates.

PubMed

McDermott, Danielle; Olson Reichhardt, Cynthia J; Reichhardt, Charles

2016-10-19

Using computer simulations, we study a two-dimensional system of sterically interacting self-mobile run-and-tumble disk-shaped particles with an underlying periodic quasi-one-dimensional asymmetric substrate, and show that a rich variety of collective active ratchet behaviors arise as a function of particle density, activity, substrate period, and the maximum force exerted by the substrate. The net dc drift, or ratchet transport flux, is nonmonotonic since it increases with increased activity but is diminished by the onset of self-clustering of the active particles. Increasing the particle density decreases the ratchet transport flux for shallow substrates but increases the ratchet transport flux for deep substrates due to collective hopping events. At the highest particle densities, the ratchet motion is destroyed by a self-jamming effect. We show that it is possible to realize reversals of the direction of the net dc drift in the deep substrate limit when multiple rows of active particles can be confined in each substrate minimum, permitting emergent particle-like excitations to appear that experience an inverted effective substrate potential. We map out a phase diagram of the forward and reverse ratchet effects as a function of the particle density, activity, and substrate properties.

Single Particle Orientation and Rotational Tracking (SPORT) in biophysical studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gu, Yan; Ha, Ji Won; Augspurger, Ashley E.

The single particle orientation and rotational tracking (SPORT) techniques have seen rapid development in the past 5 years. Recent technical advances have greatly expanded the applicability of SPORT in biophysical studies. In this feature article, we survey the current development of SPORT and discuss its potential applications in biophysics, including cellular membrane processes and intracellular transport.

Three-dimensional particle tracking via tunable color-encoded multiplexing.

PubMed

Duocastella, Martí; Theriault, Christian; Arnold, Craig B

2016-03-01

We present a novel 3D tracking approach capable of locating single particles with nanometric precision over wide axial ranges. Our method uses a fast acousto-optic liquid lens implemented in a bright field microscope to multiplex light based on color into different and selectable focal planes. By separating the red, green, and blue channels from an image captured with a color camera, information from up to three focal planes can be retrieved. Multiplane information from the particle diffraction rings enables precisely locating and tracking individual objects up to an axial range about 5 times larger than conventional single-plane approaches. We apply our method to the 3D visualization of the well-known coffee-stain phenomenon in evaporating water droplets.

Colloid Surface Chemistry Critically Affects Multiple Particle Tracking Measurements of Biomaterials

PubMed Central

Valentine, M. T.; Perlman, Z. E.; Gardel, M. L.; Shin, J. H.; Matsudaira, P.; Mitchison, T. J.; Weitz, D. A.

2004-01-01

Characterization of the properties of complex biomaterials using microrheological techniques has the promise of providing fundamental insights into their biomechanical functions; however, precise interpretations of such measurements are hindered by inadequate characterization of the interactions between tracers and the networks they probe. We here show that colloid surface chemistry can profoundly affect multiple particle tracking measurements of networks of fibrin, entangled F-actin solutions, and networks of cross-linked F-actin. We present a simple protocol to render the surface of colloidal probe particles protein-resistant by grafting short amine-terminated methoxy-poly(ethylene glycol) to the surface of carboxylated microspheres. We demonstrate that these poly(ethylene glycol)-coated tracers adsorb significantly less protein than particles coated with bovine serum albumin or unmodified probe particles. We establish that varying particle surface chemistry selectively tunes the sensitivity of the particles to different physical properties of their microenvironments. Specifically, particles that are weakly bound to a heterogeneous network are sensitive to changes in network stiffness, whereas protein-resistant tracers measure changes in the viscosity of the fluid and in the network microstructure. We demonstrate experimentally that two-particle microrheology analysis significantly reduces differences arising from tracer surface chemistry, indicating that modifications of network properties near the particle do not introduce large-scale heterogeneities. Our results establish that controlling colloid-protein interactions is crucial to the successful application of multiple particle tracking techniques to reconstituted protein networks, cytoplasm, and cells. PMID:15189896

Fluorescence imaging of microbe-containing particles shot from a two-stage Light-gas gun into an aerogel.

PubMed

Kawaguchi, Yuko; Sugino, Tomohiro; Tabata, Makoto; Okudaira, Kyoko; Imai, Eichi; Yano, Hajime; Hasegawa, Sunao; Hashimoto, Hirofumi; Yabuta, Hikaru; Kobayashi, Kensei; Kawai, Hideyuki; Mita, Hajime; Yokobori, Shin-ichi; Yamagishi, Akihiko

2014-02-01

We have proposed an experiment (the Tanpopo mission) to capture microbes on the Japan Experimental Module of the International Space Station. An ultra low-density silica aerogel will be exposed to space for more than 1 year. After retrieving the aerogel, particle tracks and particles found in it will be visualized by fluorescence microscopy after staining it with a DNA-specific fluorescence dye. In preparation for this study, we simulated particle trapping in an aerogel so that methods could be developed to visualize the particles and their tracks. During the Tanpopo mission, particles that have an orbital velocity of ~8 km/s are expected to collide with the aerogel. To simulate these collisions, we shot Deinococcus radiodurans-containing Lucentite particles into the aerogel from a two-stage light-gas gun (acceleration 4.2 km/s). The shapes of the captured particles, and their tracks and entrance holes were recorded with a microscope/camera system for further analysis. The size distribution of the captured particles was smaller than the original distribution, suggesting that the particles had fragmented. We were able to distinguish between microbial DNA and inorganic compounds after staining the aerogel with the DNA-specific fluorescence dye SYBR green I as the fluorescence of the stained DNA and the autofluorescence of the inorganic particles decay at different rates. The developed methods are suitable to determine if microbes exist at the International Space Station altitude.

Investigations of lunar materials

NASA Technical Reports Server (NTRS)

Comstock, G. M.; Fvwaraye, A. O.; Fleischer, R. L.; Hart, H. R., Jr.

1972-01-01

The investigations were directed at determining the radiation history and surface chronology of lunar materials using the etched particle track technique. The major lunar materials studied are the igneous rocks and double core from Apollo 12, the breccia and soil samples from Apollo 14, and the core samples from Luna 16. In the course of this work two new and potentially important observations were made: (1) Cosmic ray-induced spallation-recoil tracks were identified. The density of such tracks, when compared with the density of tracks induced by a known flux of accelerator protons, yields the time of exposure of a sample within the top meter or two of moon's surface. (2) Natural, fine scale plastic deformation was found to have fragmented pre-existing charged particle tracks, allowing the dating of the mechanical event causing the deformation.

Particle flow within a transonic compressor rotor passage with application to laser-Doppler velocimetry

NASA Technical Reports Server (NTRS)

Maxwell, B. R.

1975-01-01

A theoretical analysis was conducted of the dynamic behavior of micron size particles moving in the three-dimensional flow field of a rotating transonic axial-flow air compressor rotor. The particle velocity lag and angular deviation relative to the gas were determined as functions of particle diameter, mass density and radial position. Particle size and density were varied over ranges selected to correspond to typical laser-Doppler velocimeter (LDV) flow field mapping applications. It was found that the particles move essentially on gas stream surfaces and that particle tracking is relatively insensitive to the rotor radial coordinate. Velocity lag and angular deviation increased whenever particle size or mass density increased, and particle tracking was more sensitive to a change in particle diameter than to a corresponding change in mass density. Results indicated that velocity and angular deviations generally less than 1 percent and 1 degree could be achieved with 1 gm/cc tracer particles with diameters of 1 micron or less.

The effects of intraparticle and interparticle interactions on the magnetic hysteresis loop of frozen suspensions of bionized nanoferrite particles

NASA Astrophysics Data System (ADS)

Boekelheide, Zoe; Gruettner, Cordula; Dennis, Cindi

Bionized nano-ferrite (iron oxide/dextran) nanoparticles have been shown to have a large heating response in an alternating magnetic field, making them very promising for applications in magnetic nanoparticle hyperthermia cancer treatment. Magnetic hysteresis loop measurements of these particles provide insight into the magnetic reversal behavior of these particles, and thus their heating response. Measurements have been performed on frozen suspensions of nanoparticles dispersed in H2O, which have been frozen in a range of applied fields in order to tune the interparticle dipolar interactions through formation of linear chains. These experimental results are compared with micromagnetic models of both monolithic (single-domain) and internally structured (multi-grain) particles. It is found that the internal structure of the nanoparticles, which are made up of parallelepiped-shaped grains, is important for describing the magnetic reversal behavior of the particles and the resulting shape of the hysteresis loops. In addition to this, interparticle interactions between particles in a linear chain modify the reversal behavior and thus the shape of the hysteresis loop.

[Properties of synthesized CdS nanoparticles by reverse micelle method].

PubMed

Li, Heng-Da; Wang, Qing-Wei; Zhai, Hong-Ju; Li, Wen-Lian

2008-07-01

Micelle system with reverse phase (water/CTAB/n-hexyl alcohol/n-heptane) is a weenie liquid-globelet of surface active agent molecule which can be stably and uniformly dispersed in continuous oil medium. The micelle system with reverse phase can work as a "micro-reactor" to synthesize CdS nano-particle with excellent performance. In the present article considering the effects of W value (W= [water]/[surface agent]) of the micelle system with reverse phase, we observed that the ratio of [Cd2+] and [S2-] ions to the original concentrations of the Cd2+ and S2- ions can affect the luminescent properties of CdS nano-particle. Using regurgitant treatment process the surface of CdS nano-particle can be modified, and as a result the defect emission was reduced and even disappeared, but exciton emissions markedly increased. On the other hand, a red-shift of the exciton emission peak with the increase in the particle size was observed, indicating considerable quantum confinement effect. A maximum quantum efficiency of 11% for the synthesized CdS nano-material was achieved.

Reversible Redox Effect on Gas Permeation of Cobalt Doped Ethoxy Polysiloxane (ES40) Membranes

PubMed Central

Miller, Christopher R.; Wang, David K.; Smart, Simon; Diniz da Costa, João C.

2013-01-01

This work reports the remarkable effect of reversible gas molecular sieving for high temperature gas separation from cobalt doped ethoxy polysiloxane (CoES40) membranes. This effect stemmed from alternating the reducing and oxidising (redox) state of the cobalt particles embedded in the ES40 matrix. The reduced membranes gave the best H2 permeances of 1 × 10−6 mol m−2 s−1 Pa−1 and H2/N2 permselectivities of 65. The reduction process tailored a molecular gap attributed to changes in the specific volume between the reduced cobalt (Co(OH)2 and CoO) particles in the ES40 structure, thus allowing for the increased diffusion of gases. Upon re-oxidation, the tailored molecular gap became constricted as the particles reversed to Co3O4 resulting a lower gas diffusion, particularly for the larger gases ie. CO2 and N2. The ES40 matrix proved to be structurally rigid enough to withstand the reversible redox effect of cobalt particles across multiple cycles. PMID:23571730

Charge reversible gold nanoparticles for high efficient absorption and desorption of DNA

NASA Astrophysics Data System (ADS)

Wang, Can; Zhuang, Jiaqi; Jiang, Shan; Li, Jun; Yang, Wensheng

2012-10-01

Mercaptoundecylamine and mercaptoundecanoic acid co-modified Au nanoparticles were prepared by two-step ligand exchange of 6-mercaptohexanoic acid modified gold nanoparticles. Such particles terminated by appropriate ratios of the amine and carboxyl groups ( R N/C) were identified to show reversible charge on their surface, which were switchable by pH of the solution. The isoelectric point (IEP) of the particles is tunable by changing the ratios of the amine and carboxyl groups on the particle surfaces. The particles can absorb DNA effectively at pH lower than the IEP driven by the direct electrostatic interactions between DNA and the particle surface. When pH of the solutions was elevated to be higher than the IEP, the absorbed DNA can be released almost completely due to the electrostatic repulsion between the particle surface and DNA. With appropriate R N/C ratios of 0.8, the absorption and desorption efficiencies of DNA were 97 and 98 %, respectively, corresponding an extraction efficiency of 95 %. Such particles with reversible surface charges allow the high efficient extraction of DNA by simply changing pH instead of by changing salt concentration in the conventional salt bridge method.

High throughput on-chip analysis of high-energy charged particle tracks using lensfree imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Wei; Shabbir, Faizan; Gong, Chao

2015-04-13

We demonstrate a high-throughput charged particle analysis platform, which is based on lensfree on-chip microscopy for rapid ion track analysis using allyl diglycol carbonate, i.e., CR-39 plastic polymer as the sensing medium. By adopting a wide-area opto-electronic image sensor together with a source-shifting based pixel super-resolution technique, a large CR-39 sample volume (i.e., 4 cm × 4 cm × 0.1 cm) can be imaged in less than 1 min using a compact lensfree on-chip microscope, which detects partially coherent in-line holograms of the ion tracks recorded within the CR-39 detector. After the image capture, using highly parallelized reconstruction and ion track analysis algorithms running on graphics processingmore » units, we reconstruct and analyze the entire volume of a CR-39 detector within ∼1.5 min. This significant reduction in the entire imaging and ion track analysis time not only increases our throughput but also allows us to perform time-resolved analysis of the etching process to monitor and optimize the growth of ion tracks during etching. This computational lensfree imaging platform can provide a much higher throughput and more cost-effective alternative to traditional lens-based scanning optical microscopes for ion track analysis using CR-39 and other passive high energy particle detectors.« less

Charge, energy and LET spectra of high LET primary and secondary particles in CR-39 plastic nuclear track detectors of the P0006 experiment

NASA Technical Reports Server (NTRS)

Csige, I.; Frigo, L. A.; Benton, E. V.; Oda, K.

1995-01-01

We have measured the charge, energy and linear energy transfer (LET) spectra of about 800 high LET (LET(sub infinity) H2O greater than 50 keV/micron) particles in CR-39 plastic nuclear track detectors in the P0006 experiment of LDEF. Primary particles with residual range at the reference surface greater than about 2 microns and secondary particles produced in the detector material with total range greater than about 4 microns were measured. We have used a multi-etch technique and an internal calibration to identify and measure the energy of the particles at the reference surface. The LET spectrum was obtained from the charge and energy distribution of the particles.

Comparative assessment of pressure field reconstructions from particle image velocimetry measurements and Lagrangian particle tracking

NASA Astrophysics Data System (ADS)

van Gent, P. L.; Michaelis, D.; van Oudheusden, B. W.; Weiss, P.-É.; de Kat, R.; Laskari, A.; Jeon, Y. J.; David, L.; Schanz, D.; Huhn, F.; Gesemann, S.; Novara, M.; McPhaden, C.; Neeteson, N. J.; Rival, D. E.; Schneiders, J. F. G.; Schrijer, F. F. J.

2017-04-01

A test case for pressure field reconstruction from particle image velocimetry (PIV) and Lagrangian particle tracking (LPT) has been developed by constructing a simulated experiment from a zonal detached eddy simulation for an axisymmetric base flow at Mach 0.7. The test case comprises sequences of four subsequent particle images (representing multi-pulse data) as well as continuous time-resolved data which can realistically only be obtained for low-speed flows. Particle images were processed using tomographic PIV processing as well as the LPT algorithm `Shake-The-Box' (STB). Multiple pressure field reconstruction techniques have subsequently been applied to the PIV results (Eulerian approach, iterative least-square pseudo-tracking, Taylor's hypothesis approach, and instantaneous Vortex-in-Cell) and LPT results (FlowFit, Vortex-in-Cell-plus, Voronoi-based pressure evaluation, and iterative least-square pseudo-tracking). All methods were able to reconstruct the main features of the instantaneous pressure fields, including methods that reconstruct pressure from a single PIV velocity snapshot. Highly accurate reconstructed pressure fields could be obtained using LPT approaches in combination with more advanced techniques. In general, the use of longer series of time-resolved input data, when available, allows more accurate pressure field reconstruction. Noise in the input data typically reduces the accuracy of the reconstructed pressure fields, but none of the techniques proved to be critically sensitive to the amount of noise added in the present test case.

Impact of x-ray dose on the response of CR-39 to 1–5.5 MeV alphas

DOE PAGES

Rojas-Herrera, J.; Rinderknecht, H. G.; Zylstra, A. B.; ...

2015-03-01

The CR-39 nuclear track detector is used in many nuclear diagnostics fielded at inertial confinement fusion (ICF) facilities. Large x-ray uences generated by ICF experiments may impact the CR-39 response to incident charged particles. To determine the impact of x-ray exposure on the CR-39 response to alpha particles, a thick-target bremsstrahlung x-ray generator was used to expose CR-39 to various doses of 8 keV Cu-K α and K β x-rays. The CR-39 detectors were then exposed to 1-5.5 MeV alphas from an Am-241 source. The regions of the CR-39 exposed to x-rays showed a smaller track diameter than those notmore » exposed to x-rays: for example, a dose of 3.0 ± 0.1 Gy causes a decrease of (19 ± 2)% in the track diameter of a 5.5 MeV alpha particle, while a dose of 60.0 ± 1.3 Gy results in a decrease of (45 ± 5)% in the track diameter. The reduced track diameters were found to be predominantly caused by a comparable reduction in the bulk etch rate of the CR-39 with x-ray dose. A residual effect depending on alpha particle energy is characterized using an empirical formula.« less

Performance of the ATLAS track reconstruction algorithms in dense environments in LHC Run 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaboud, M.; Aad, G.; Abbott, B.

With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 TeV for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.2 fb -1 of data collected by the ATLAS experiment and simulation of proton–proton collisions producing high-transverse-momentum jets at a centre-of-mass energy of 13 TeV. The impact of charged-particle separations andmore » multiplicities on the track reconstruction performance is discussed. The track reconstruction efficiency in the cores of jets with transverse momenta between 200 and 1600 GeV is quantified using a novel, data-driven, method. The method uses the energy loss, dE/dx, to identify pixel clusters originating from two charged particles. Of the charged particles creating these clusters, the measured fraction that fail to be reconstructed is 0.061±0.006 (stat.)±0.014 (syst.) and 0.093±0.017 (stat.)±0.021 (syst.) for jet transverse momenta of 200–400 GeV and 1400–1600 GeV, respectively.« less

Performance of the ATLAS track reconstruction algorithms in dense environments in LHC Run 2

DOE PAGES

Aaboud, M.; Aad, G.; Abbott, B.; ...

2017-10-11

With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 TeV for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.2 fb -1 of data collected by the ATLAS experiment and simulation of proton–proton collisions producing high-transverse-momentum jets at a centre-of-mass energy of 13 TeV. The impact of charged-particle separations andmore » multiplicities on the track reconstruction performance is discussed. The track reconstruction efficiency in the cores of jets with transverse momenta between 200 and 1600 GeV is quantified using a novel, data-driven, method. The method uses the energy loss, dE/dx, to identify pixel clusters originating from two charged particles. Of the charged particles creating these clusters, the measured fraction that fail to be reconstructed is 0.061±0.006 (stat.)±0.014 (syst.) and 0.093±0.017 (stat.)±0.021 (syst.) for jet transverse momenta of 200–400 GeV and 1400–1600 GeV, respectively.« less

Physical Models for Particle Tracking Simulations in the RF Gap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shishlo, Andrei P.; Holmes, Jeffrey A.

2015-06-01

This document describes the algorithms that are used in the PyORBIT code to track the particles accelerated in the Radio-Frequency cavities. It gives the mathematical description of the algorithms and the assumptions made in each case. The derived formulas have been implemented in the PyORBIT code. The necessary data for each algorithm are described in detail.

4D tracking with ultra-fast silicon detectors

NASA Astrophysics Data System (ADS)

F-W Sadrozinski, Hartmut; Seiden, Abraham; Cartiglia, Nicolò

2018-02-01

The evolution of particle detectors has always pushed the technological limit in order to provide enabling technologies to researchers in all fields of science. One archetypal example is the evolution of silicon detectors, from a system with a few channels 30 years ago, to the tens of millions of independent pixels currently used to track charged particles in all major particle physics experiments. Nowadays, silicon detectors are ubiquitous not only in research laboratories but in almost every high-tech apparatus, from portable phones to hospitals. In this contribution, we present a new direction in the evolution of silicon detectors for charge particle tracking, namely the inclusion of very accurate timing information. This enhancement of the present silicon detector paradigm is enabled by the inclusion of controlled low gain in the detector response, therefore increasing the detector output signal sufficiently to make timing measurement possible. After providing a short overview of the advantage of this new technology, we present the necessary conditions that need to be met for both sensor and readout electronics in order to achieve 4D tracking. In the last section, we present the experimental results, demonstrating the validity of our research path.

Real-time image processing for particle tracking velocimetry

NASA Astrophysics Data System (ADS)

Kreizer, Mark; Ratner, David; Liberzon, Alex

2010-01-01

We present a novel high-speed particle tracking velocimetry (PTV) experimental system. Its novelty is due to the FPGA-based, real-time image processing "on camera". Instead of an image, the camera transfers to the computer using a network card, only the relevant information of the identified flow tracers. Therefore, the system is ideal for the remote particle tracking systems in research and industrial applications, while the camera can be controlled and data can be transferred over any high-bandwidth network. We present the hardware and the open source software aspects of the PTV experiments. The tracking results of the new experimental system has been compared to the flow visualization and particle image velocimetry measurements. The canonical flow in the central cross section of a a cubic cavity (1:1:1 aspect ratio) in our lid-driven cavity apparatus is used for validation purposes. The downstream secondary eddy (DSE) is the sensitive portion of this flow and its size was measured with increasing Reynolds number (via increasing belt velocity). The size of DSE estimated from the flow visualization, PIV and compressed PTV is shown to agree within the experimental uncertainty of the methods applied.

Single Charged Particle Identification in Nuclear Emulsion Using Multiple Coulomb Scattering Method

NASA Astrophysics Data System (ADS)

Tint, Khin T.; Endo, Yoko; Hoshino, Kaoru; Ito, Hiroki; Itonaga, Kazunori; Kinbara, Shinji; Kobayashi, Hidetaka; Mishina, Akihiro; Soe, Myint K.; Yoshida, Junya; Nakazawa, Kazuma

Development of particle identification technique for single charged particles such as Ξ- hyperon, proton, K- and π- mesons is on-going by measuring multiple Coulomb scattering in nuclear emulsion. We generated several thousands of tracks of the single charged particles in nuclear emulsion stacks with GEANT 4 simulation and obtained second difference in constant Sagitta Method. We found that recognition of Ξ- hyperon from π- mesons is well satisfied, although that from K- and proton are a little difficult. On the other hand, the consistency of second difference of real Ξ- hyperon and pi meson tracks and simulation results were also confirmed.

Bayesian approach to analyzing holograms of colloidal particles.

PubMed

Dimiduk, Thomas G; Manoharan, Vinothan N

2016-10-17

We demonstrate a Bayesian approach to tracking and characterizing colloidal particles from in-line digital holograms. We model the formation of the hologram using Lorenz-Mie theory. We then use a tempered Markov-chain Monte Carlo method to sample the posterior probability distributions of the model parameters: particle position, size, and refractive index. Compared to least-squares fitting, our approach allows us to more easily incorporate prior information about the parameters and to obtain more accurate uncertainties, which are critical for both particle tracking and characterization experiments. Our approach also eliminates the need to supply accurate initial guesses for the parameters, so it requires little tuning.

Kassiopeia: a modern, extensible C++ particle tracking package

DOE Office of Scientific and Technical Information (OSTI.GOV)

Furse, Daniel; Groh, Stefan; Trost, Nikolaus

The Kassiopeia particle tracking framework is an object-oriented software package using modern C++ techniques, written originally to meet the needs of the KATRIN collaboration. Kassiopeia features a new algorithmic paradigm for particle tracking simulations which targets experiments containing complex geometries and electromagnetic fields, with high priority put on calculation efficiency, customizability, extensibility, and ease-of-use for novice programmers. To solve Kassiopeia's target physics problem the software is capable of simulating particle trajectories governed by arbitrarily complex differential equations of motion, continuous physics processes that may in part be modeled as terms perturbing that equation of motion, stochastic processes that occur inmore » flight such as bulk scattering and decay, and stochastic surface processes occurring at interfaces, including transmission and reflection effects. This entire set of computations takes place against the backdrop of a rich geometry package which serves a variety of roles, including initialization of electromagnetic field simulations and the support of state-dependent algorithm-swapping and behavioral changes as a particle's state evolves. Thanks to the very general approach taken by Kassiopeia it can be used by other experiments facing similar challenges when calculating particle trajectories in electromagnetic fields. It is publicly available at https://github.com/KATRIN-Experiment/Kassiopeia.« less

Comparison of three-dimensional particle tracking and sizing using plenoptic imaging and digital in-line holography.

PubMed

Hall, Elise M; Thurow, Brian S; Guildenbecher, Daniel R

2016-08-10

Digital in-line holography (DIH) and plenoptic photography are two techniques for single-shot, volumetric measurement of 3D particle fields. Here we present a comparison of the two methods by applying plenoptic imaging to experimental configurations that have been previously investigated with DIH. These experiments include the tracking of secondary droplets from the impact of a water drop on a thin film of water and tracking of pellets from a shotgun. Both plenoptic imaging and DIH successfully quantify the 3D nature of these particle fields. This includes measurement of the 3D particle position, individual particle sizes, and three-component velocity vectors. For the initial processing methods presented here, both techniques give out-of-plane positional accuracy of approximately 1-2 particle diameters. For a fixed image sensor, digital holography achieves higher effective in-plane spatial resolutions. However, collimated and coherent illumination makes holography susceptible to image distortion through index of refraction gradients, as demonstrated in the shotgun experiments. In contrast, plenoptic imaging allows for a simpler experimental configuration and, due to the use of diffuse, white-light illumination, plenoptic imaging is less susceptible to image distortion in the shotgun experiments.

Kassiopeia: a modern, extensible C++ particle tracking package

DOE PAGES

Furse, Daniel; Groh, Stefan; Trost, Nikolaus; ...

2017-05-16

The Kassiopeia particle tracking framework is an object-oriented software package using modern C++ techniques, written originally to meet the needs of the KATRIN collaboration. Kassiopeia features a new algorithmic paradigm for particle tracking simulations which targets experiments containing complex geometries and electromagnetic fields, with high priority put on calculation efficiency, customizability, extensibility, and ease-of-use for novice programmers. To solve Kassiopeia's target physics problem the software is capable of simulating particle trajectories governed by arbitrarily complex differential equations of motion, continuous physics processes that may in part be modeled as terms perturbing that equation of motion, stochastic processes that occur inmore » flight such as bulk scattering and decay, and stochastic surface processes occurring at interfaces, including transmission and reflection effects. This entire set of computations takes place against the backdrop of a rich geometry package which serves a variety of roles, including initialization of electromagnetic field simulations and the support of state-dependent algorithm-swapping and behavioral changes as a particle's state evolves. Thanks to the very general approach taken by Kassiopeia it can be used by other experiments facing similar challenges when calculating particle trajectories in electromagnetic fields. It is publicly available at https://github.com/KATRIN-Experiment/Kassiopeia.« less

Particle image velocimetry for the Surface Tension Driven Convection Experiment using a particle displacement tracking technique

NASA Technical Reports Server (NTRS)

Wernet, Mark P.; Pline, Alexander D.

1991-01-01

The Surface Tension Driven Convection Experiment (STDCE) is a Space Transportation System flight experiment to study both transient and steady thermocapillary fluid flows aboard the USML-1 Spacelab mission planned for 1992. One of the components of data collected during the experiment is a video record of the flow field. This qualitative data is then quantified using an all electronic, two-dimensional particle image velocimetry technique called particle displacement tracking (PDT) which uses a simple space domain particle tracking algorithm. The PDT system is successful in producing velocity vector fields from the raw video data. Application of the PDT technique to a sample data set yielded 1606 vectors in 30 seconds of processing time. A bottom viewing optical arrangement is used to image the illuminated plane, which causes keystone distortion in the final recorded image. A coordinate transformation was incorporated into the system software to correct this viewing angle distortion. PDT processing produced 1.8 percent false identifications, due to random particle locations. A highly successful routine for removing the false identifications was also incorporated, reducing the number of false identifications to 0.2 percent.

Tracking Debris Shed by a Space-Shuttle Launch Vehicle

NASA Technical Reports Server (NTRS)

Stuart, Phillip C.; Rogers, Stuart E.

2009-01-01

The DEBRIS software predicts the trajectories of debris particles shed by a space-shuttle launch vehicle during ascent, to aid in assessing potential harm to the space-shuttle orbiter and crew. The user specifies the location of release and other initial conditions for a debris particle. DEBRIS tracks the particle within an overset grid system by means of a computational fluid dynamics (CFD) simulation of the local flow field and a ballistic simulation that takes account of the mass of the particle and its aerodynamic properties in the flow field. The computed particle trajectory is stored in a file to be post-processed by other software for viewing and analyzing the trajectory. DEBRIS supplants a prior debris tracking code that took .15 minutes to calculate a single particle trajectory: DEBRIS can calculate 1,000 trajectories in .20 seconds on a desktop computer. Other improvements over the prior code include adaptive time-stepping to ensure accuracy, forcing at least one step per grid cell to ensure resolution of all CFD-resolved flow features, ability to simulate rebound of debris from surfaces, extensive error checking, a builtin suite of test cases, and dynamic allocation of memory.

Particle image velocimetry for the surface tension driven convection experiment using a particle displacement tracking technique

NASA Technical Reports Server (NTRS)

Wernet, Mark P.; Pline, Alexander D.

1991-01-01

The Surface Tension Driven Convection Experiment (STDCE) is a Space Transportation System flight experiment to study both transient and steady thermocapillary fluid flows aboard the USML-1 Spacelab mission planned for 1992. One of the components of data collected during the experiment is a video record of the flow field. This qualitative data is then quantified using an all electronic, two-dimensional particle image velocimetry technique called particle displacement tracking (PDT) which uses a simple space domain particle tracking algorithm. The PDT system is successful in producing velocity vector fields from the raw video data. Application of the PDT technique to a sample data set yielded 1606 vectors in 30 seconds of processing time. A bottom viewing optical arrangement is used to image the illuminated plane, which causes keystone distortion in the final recorded image. A coordinate transformation was incorporated into the system software to correct this viewing angle distortion. PDT processing produced 1.8 percent false identifications, due to random particle locations. A highly successful routine for removing the false identifications was also incorporated, reducing the number of false identifications to 0.2 percent.

Autoradiography imaging in targeted alpha therapy with Timepix detector.

PubMed

A L Darwish, Ruqaya; Staudacher, Alexander Hugo; Bezak, Eva; Brown, Michael Paul

2015-01-01

There is a lack of data related to activity uptake and particle track distribution in targeted alpha therapy. These data are required to estimate the absorbed dose on a cellular level as alpha particles have a limited range and traverse only a few cells. Tracking of individual alpha particles is possible using the Timepix semiconductor radiation detector. We investigated the feasibility of imaging alpha particle emissions in tumour sections from mice treated with Thorium-227 (using APOMAB), with and without prior chemotherapy and Timepix detector. Additionally, the sensitivity of the Timepix detector to monitor variations in tumour uptake based on the necrotic tissue volume was also studied. Compartmental analysis model was used, based on the obtained imaging data, to assess the Th-227 uptake. Results show that alpha particle, photon, electron, and muon tracks were detected and resolved by Timepix detector. The current study demonstrated that individual alpha particle emissions, resulting from targeted alpha therapy, can be visualised and quantified using Timepix detector. Furthermore, the variations in the uptake based on the tumour necrotic volume have been observed with four times higher uptake for tumours pretreated with chemotherapy than for those without chemotherapy.

Autoradiography Imaging in Targeted Alpha Therapy with Timepix Detector

PubMed Central

AL Darwish, Ruqaya; Staudacher, Alexander Hugo; Bezak, Eva; Brown, Michael Paul

2015-01-01

There is a lack of data related to activity uptake and particle track distribution in targeted alpha therapy. These data are required to estimate the absorbed dose on a cellular level as alpha particles have a limited range and traverse only a few cells. Tracking of individual alpha particles is possible using the Timepix semiconductor radiation detector. We investigated the feasibility of imaging alpha particle emissions in tumour sections from mice treated with Thorium-227 (using APOMAB), with and without prior chemotherapy and Timepix detector. Additionally, the sensitivity of the Timepix detector to monitor variations in tumour uptake based on the necrotic tissue volume was also studied. Compartmental analysis model was used, based on the obtained imaging data, to assess the Th-227 uptake. Results show that alpha particle, photon, electron, and muon tracks were detected and resolved by Timepix detector. The current study demonstrated that individual alpha particle emissions, resulting from targeted alpha therapy, can be visualised and quantified using Timepix detector. Furthermore, the variations in the uptake based on the tumour necrotic volume have been observed with four times higher uptake for tumours pretreated with chemotherapy than for those without chemotherapy. PMID:25688285

Track propagation methods for the correlation of charged tracks with clusters in the calorimeter of the bar PANDA experiment

NASA Astrophysics Data System (ADS)

Nasawasd, T.; Simantathammakul, T.; Herold, C.; Stockmanns, T.; Ritman, J.; Kobdaj, C.

2018-02-01

To classify clusters of hits in the electromagnetic calorimeter (EMC) of bar PANDA (antiProton ANnihilation at DArmstadt), one has to match these EMC clusters with tracks of charged particles reconstructed from hits in the tracking system. Therefore the tracks are propagated to the surface of the EMC and associated with EMC clusters which are nearby and below a cut parameter. In this work, we propose a helix propagator to extrapolate the track from the Straw Tube Tracker (STT) to the inner surface of the EMC instead of the GEANE propagator which is already embedded within the PandaRoot computational framework. The results for both propagation methods show a similar quality, with a 30% gain in CPU time when using the helix propagator. We use Monte-Carlo truth information to compare the particle ID of the EMC clusters with the ID of the extrapolated points, thus deciding upon the correctness of the matches. By varying the cut parameter as a function of transverse momentum and particle type, our simulations show that the purity can be increased by 3-5% compared to the default value which is a constant cut in the bar PANDA simulation framework PandaRoot.

Triple tracks in CR-39 as the result of Pd-D Co-deposition: evidence of energetic neutrons.

PubMed

Mosier-Boss, Pamela A; Szpak, Stanislaw; Gordon, Frank E; Forsley, Lawrence P G

2009-01-01

Since the announcement by Fleischmann and Pons that the excess enthalpy generated in the negatively polarized Pd-D-D(2)O system was attributable to nuclear reactions occurring inside the Pd lattice, there have been reports of other manifestations of nuclear activities in this system. In particular, there have been reports of tritium and helium-4 production; emission of energetic particles, gamma or X-rays, and neutrons; as well as the transmutation of elements. In this communication, the results of Pd-D co-deposition experiments conducted with the cathode in close contact with CR-39, a solid-state nuclear etch detector, are reported. Among the solitary tracks due to individual energetic particles, triple tracks are observed. Microscopic examination of the bottom of the triple track pit shows that the three lobes of the track are splitting apart from a center point. The presence of three alpha-particle tracks outgoing from a single point is diagnostic of the (12)C(n,n')3alpha carbon breakup reaction and suggests that DT reactions that produce > or = 9.6 MeV neutrons are occurring inside the Pd lattice. To our knowledge, this is the first report of the production of energetic (> or = 9.6 MeV) neutrons in the Pd-D system.

Space debris tracking based on fuzzy running Gaussian average adaptive particle filter track-before-detect algorithm

NASA Astrophysics Data System (ADS)

Torteeka, Peerapong; Gao, Peng-Qi; Shen, Ming; Guo, Xiao-Zhang; Yang, Da-Tao; Yu, Huan-Huan; Zhou, Wei-Ping; Zhao, You

2017-02-01

Although tracking with a passive optical telescope is a powerful technique for space debris observation, it is limited by its sensitivity to dynamic background noise. Traditionally, in the field of astronomy, static background subtraction based on a median image technique has been used to extract moving space objects prior to the tracking operation, as this is computationally efficient. The main disadvantage of this technique is that it is not robust to variable illumination conditions. In this article, we propose an approach for tracking small and dim space debris in the context of a dynamic background via one of the optical telescopes that is part of the space surveillance network project, named the Asia-Pacific ground-based Optical Space Observation System or APOSOS. The approach combines a fuzzy running Gaussian average for robust moving-object extraction with dim-target tracking using a particle-filter-based track-before-detect method. The performance of the proposed algorithm is experimentally evaluated, and the results show that the scheme achieves a satisfactory level of accuracy for space debris tracking.

Tomographic Aperture-Encoded Particle Tracking Velocimetry: A New Approach to Volumetric PIV

NASA Astrophysics Data System (ADS)

Troolin, Dan; Boomsma, Aaron; Lai, Wing; Pothos, Stamatios; Fluid Mechanics Research Instruments Team

2016-11-01

Volumetric velocity fields are useful in a wide variety of fluid mechanics applications. Several types of three-dimensional imaging methods have been used in the past to varying degrees of success, for example, 3D PTV (Maas et al., 1993), DDPIV (Peireira et al., 2006), Tomographic PIV (Elsinga, 2006), and V3V (Troolin and Longmire, 2009), among others. Each of these techniques has shown advantages and disadvantages in different areas. With the advent of higher resolution and lower noise cameras with higher stability levels, new techniques are emerging that combine the advantages of the existing techniques. This talk describes a new technique called Tomographic Aperture-Encoded Particle Tracking Velocimetry (TAPTV), in which segmented triangulation and diameter tolerance are used to achieve three-dimensional particle tracking with extremely high particle densities (on the order of ppp = 0.2 or higher) without the drawbacks normally associated with ghost particles (for example in TomoPIV). The results are highly spatially-resolved data with very fast processing times. A detailed explanation of the technique as well as plots, movies, and experimental considerations will be discussed.

Symplectic multi-particle tracking on GPUs

NASA Astrophysics Data System (ADS)

Liu, Zhicong; Qiang, Ji

2018-05-01

A symplectic multi-particle tracking model is implemented on the Graphic Processing Units (GPUs) using the Compute Unified Device Architecture (CUDA) language. The symplectic tracking model can preserve phase space structure and reduce non-physical effects in long term simulation, which is important for beam property evaluation in particle accelerators. Though this model is computationally expensive, it is very suitable for parallelization and can be accelerated significantly by using GPUs. In this paper, we optimized the implementation of the symplectic tracking model on both single GPU and multiple GPUs. Using a single GPU processor, the code achieves a factor of 2-10 speedup for a range of problem sizes compared with the time on a single state-of-the-art Central Processing Unit (CPU) node with similar power consumption and semiconductor technology. It also shows good scalability on a multi-GPU cluster at Oak Ridge Leadership Computing Facility. In an application to beam dynamics simulation, the GPU implementation helps save more than a factor of two total computing time in comparison to the CPU implementation.

Spectral characterization of laser-accelerated protons with CR-39 nuclear track detector.

PubMed

Seimetz, M; Bellido, P; García, P; Mur, P; Iborra, A; Soriano, A; Hülber, T; García López, J; Jiménez-Ramos, M C; Lera, R; Ruiz-de la Cruz, A; Sánchez, I; Zaffino, R; Roso, L; Benlloch, J M

2018-02-01

CR-39 nuclear track material is frequently used for the detection of protons accelerated in laser-plasma interactions. The measurement of track densities allows for determination of particle angular distributions, and information on the kinetic energy can be obtained by the use of passive absorbers. We present a precise method of measuring spectral distributions of laser-accelerated protons in a single etching and analysis process. We make use of a one-to-one relation between proton energy and track size and present a precise calibration based on monoenergetic particle beams. While this relation is limited to proton energies below 1 MeV, we show that the range of spectral measurements can be significantly extended by simultaneous use of absorbers of suitable thicknesses. Examples from laser-plasma interactions are presented, and quantitative results on proton energies and particle numbers are compared to those obtained from a time-of-flight detector. The spectrum end points of continuous energy distributions have been determined with both detector types and coincide within 50-100 keV.

Charged particle tracking through electrostatic wire meshes using the finite element method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devlin, L. J.; Karamyshev, O.; Welsch, C. P., E-mail: carsten.welsch@cockcroft.ac.uk

Wire meshes are used across many disciplines to accelerate and focus charged particles, however, analytical solutions are non-exact and few codes exist which simulate the exact fields around a mesh with physical sizes. A tracking code based in Matlab-Simulink using field maps generated using finite element software has been developed which tracks electrons or ions through electrostatic wire meshes. The fields around such a geometry are presented as an analytical expression using several basic assumptions, however, it is apparent that computational calculations are required to obtain realistic values of electric potential and fields, particularly when multiple wire meshes are deployed.more » The tracking code is flexible in that any quantitatively describable particle distribution can be used for both electrons and ions as well as other benefits such as ease of export to other programs for analysis. The code is made freely available and physical examples are highlighted where this code could be beneficial for different applications.« less

Sedimentation patterns caused by scallop dredging in a physically dynamic environment.

PubMed

Dale, A C; Boulcott, P; Sherwin, T J

2011-11-01

Scallop dredging grounds in the Firth of Lorn, western Scotland, are juxtaposed with rocky reef habitats raising concerns that reef communities may be impacted by sediment disturbed by nearby scallop dredging. A particle-tracking model of sediment transport and settling is applied at two scales. In the near-field, a suspension of typical sand/gravel-dominated bed sediment is subjected to a steady current across the dredge track. In the far-field, silt particles, which may persist in suspension for multiple tidal cycles, are tracked in the context of a regional model of tidally-driven flow. The principal sedimentary risk to reef habitats is predicted to come from settling sand particles when dredge tracks approach within tens of metres of a reef. The cumulative effect of dredging at the relatively low intensities recorded in this region is not expected to have a significant long-term impact on suspended silt concentrations and settlement in this highly dispersive environment. Copyright © 2011 Elsevier Ltd. All rights reserved.

Measurement of pattern recognition efficiency of tracks generated by ionizing radiation in a Medipix2 device

NASA Astrophysics Data System (ADS)

Bouchami, J.; Gutiérrez, A.; Holy, T.; Houdayer, A.; Jakůbek, J.; Lebel, C.; Leroy, C.; Macana, J.; Martin, J.-P.; Pospíšil, S.; Prak, S.; Sabella, P.; Teyssier, C.; CERN Medipix Collaboration

2011-05-01

Several experiments were performed to establish the Medipix2 device capabilities for track recognition and its efficiency at measuring fluxes. A Medipix2 device was exposed to 241Am, 106Ru and 137Cs radioactive sources, separately and simultaneously. It was also exposed to heavy particle beams (protons and alpha-particles), recoiled on a gold foil to reduce the incoming flux and allow the study of the detector response struck by incoming particles at different incidence angles. For three proton beams (400 keV, 4 and 10 MeV), the device was exposed to the radioactive sources on top of beam, giving a mixed radiation field. To test the reliability of track recognition with this device, the activities of the radioactive sources were extracted from the experimental data and compared to the expected activities. Rotation of the Medipix2 device allowed the test of the heavy tracks recognition at different incidence angles.

Preparation and quantification of radioactive particles for tracking hydrodynamic behavior in multiphase reactors.

PubMed

Yunos, Mohd Amirul Syafiq Mohd; Hussain, Siti Aslina; Yusoff, Hamdan Mohamed; Abdullah, Jaafar

2014-09-01

Radioactive particle tracking (RPT) has emerged as a promising and versatile technique that can provide rich information about a variety of multiphase flow systems. However, RPT is not an off-the-shelf technique, and thus, users must customize RPT for their applications. This paper presents a simple procedure for preparing radioactive tracer particles created via irradiation with neutrons from the TRIGA Mark II research reactor. The present study focuses on the performance evaluation of encapsulated gold and scandium particles for applications as individual radioactive tracer particles using qualitative and quantitative neutron activation analysis (NAA) and an X-ray microcomputed tomography (X-ray Micro-CT) scanner installed at the Malaysian Nuclear Agency. Copyright © 2014 Elsevier Ltd. All rights reserved.

Learning in Reverse: Eight-Month-Old Infants Track Backward Transitional Probabilities

ERIC Educational Resources Information Center

Pelucchi, Bruna; Hay, Jessica F.; Saffran, Jenny R.

2009-01-01

Numerous recent studies suggest that human learners, including both infants and adults, readily track sequential statistics computed between adjacent elements. One such statistic, transitional probability, is typically calculated as the likelihood that one element predicts another. However, little is known about whether listeners are sensitive to…

Nano-scale measurement of biomolecules by optical microscopy and semiconductor nanoparticles

PubMed Central

Ichimura, Taro; Jin, Takashi; Fujita, Hideaki; Higuchi, Hideo; Watanabe, Tomonobu M.

2014-01-01

Over the past decade, great developments in optical microscopy have made this technology increasingly compatible with biological studies. Fluorescence microscopy has especially contributed to investigating the dynamic behaviors of live specimens and can now resolve objects with nanometer precision and resolution due to super-resolution imaging. Additionally, single particle tracking provides information on the dynamics of individual proteins at the nanometer scale both in vitro and in cells. Complementing advances in microscopy technologies has been the development of fluorescent probes. The quantum dot, a semi-conductor fluorescent nanoparticle, is particularly suitable for single particle tracking and super-resolution imaging. This article overviews the principles of single particle tracking and super resolution along with describing their application to the nanometer measurement/observation of biological systems when combined with quantum dot technologies. PMID:25120488

Particle Filtering with Region-based Matching for Tracking of Partially Occluded and Scaled Targets*

PubMed Central

Nakhmani, Arie; Tannenbaum, Allen

2012-01-01

Visual tracking of arbitrary targets in clutter is important for a wide range of military and civilian applications. We propose a general framework for the tracking of scaled and partially occluded targets, which do not necessarily have prominent features. The algorithm proposed in the present paper utilizes a modified normalized cross-correlation as the likelihood for a particle filter. The algorithm divides the template, selected by the user in the first video frame, into numerous patches. The matching process of these patches by particle filtering allows one to handle the target’s occlusions and scaling. Experimental results with fixed rectangular templates show that the method is reliable for videos with nonstationary, noisy, and cluttered background, and provides accurate trajectories in cases of target translation, scaling, and occlusion. PMID:22506088

Single Particle Orientation and Rotational Tracking (SPORT) in biophysical studies

NASA Astrophysics Data System (ADS)

Gu, Yan; Ha, Ji Won; Augspurger, Ashley E.; Chen, Kuangcai; Zhu, Shaobin; Fang, Ning

2013-10-01

The single particle orientation and rotational tracking (SPORT) techniques have seen rapid development in the past 5 years. Recent technical advances have greatly expanded the applicability of SPORT in biophysical studies. In this feature article, we survey the current development of SPORT and discuss its potential applications in biophysics, including cellular membrane processes and intracellular transport.The single particle orientation and rotational tracking (SPORT) techniques have seen rapid development in the past 5 years. Recent technical advances have greatly expanded the applicability of SPORT in biophysical studies. In this feature article, we survey the current development of SPORT and discuss its potential applications in biophysics, including cellular membrane processes and intracellular transport. Electronic supplementary information (ESI) available: Three supplementary movies and an experimental section. See DOI: 10.1039/c3nr02254d

A parameterization of nuclear track profiles in CR-39 detector

NASA Astrophysics Data System (ADS)

Azooz, A. A.; Al-Nia'emi, S. H.; Al-Jubbori, M. A.

2012-11-01

In this work, the empirical parameterization describing the alpha particles’ track depth in CR-39 detectors is extended to describe longitudinal track profiles against etching time for protons and alpha particles. MATLAB based software is developed for this purpose. The software calculates and plots the depth, diameter, range, residual range, saturation time, and etch rate versus etching time. The software predictions are compared with other experimental data and with results of calculations using the original software, TRACK_TEST, developed for alpha track calculations. The software related to this work is freely downloadable and performs calculations for protons in addition to alpha particles. Program summary Program title: CR39 Catalog identifier: AENA_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AENA_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Copyright (c) 2011, Aasim Azooz Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met • Redistributions of source code must retain the above copyright, this list of conditions and the following disclaimer. • Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution This software is provided by the copyright holders and contributors “as is” and any express or implied warranties, including, but not limited to, the implied warranties of merchantability and fitness for a particular purpose are disclaimed. In no event shall the copyright owner or contributors be liable for any direct, indirect, incidental, special, exemplary, or consequential damages (including, but not limited to, procurement of substitute goods or services; loss of use, data, or profits; or business interruption) however caused and on any theory of liability, whether in contract, strict liability, or tort (including negligence or otherwise) arising in any way out of the use of this software, even if advised of the possibility of such damage. No. of lines in distributed program, including test data, etc.: 15598 No. of bytes in distributed program, including test data, etc.: 3933244 Distribution format: tar.gz Programming language: MATLAB. Computer: Any Desktop or Laptop. Operating system: Windows 1998 or above (with MATLAB R13 or above installed). RAM: 512 Megabytes or higher Classification: 17.5. Nature of problem: A new semispherical parameterization of charged particle tracks in CR-39 SSNTD is carried out in a previous paper. This parameterization is developed here into a MATLAB based software to calculate the track length and track profile for any proton or alpha particle energy or etching time. This software is intended to compete with the TRACK_TEST [1] and TRACK_VISION [2] software currently in use by all people working in the field of SSNTD. Solution method: Based on fitting of experimental results of protons and alpha particles track lengths for various energies and etching times to a new semispherical formula with four free fitting parameters, the best set of energy independent parameters were found. These parameters are introduced into the software and the software is programmed to solve the set of equations to calculate the track depth, track etching rate as a function of both time and residual range for particles of normal and oblique incidence, the track longitudinal profile at both normal and oblique incidence, and the three dimensional track profile at normal incidence. Running time: 1-8 s on Pentium (4) 2 GHz CPU, 3 GB of RAM depending on the etching time value References: [1] ADWT_v1_0 Track_Test Computer program TRACK_TEST for calculating parameters and plotting profiles for etch pits in nuclear track materials. D. Nikezic, K.N. Yu Comput. Phys. Commun. 174(2006)160 [2] AEAF_v1_0 TRACK_VISION Computer program TRACK_VISION for simulating optical appearance of etched tracks in CR-39 nuclear track detectors. D. Nikezic, K.N. Yu Comput. Phys. Commun. 178(2008)591

Optimum Value of Original Events on the Pept Technique

NASA Astrophysics Data System (ADS)

Sadremomtaz, Alireza; Taherparvar, Payvand

2011-12-01

Do Positron emission particle tracking (PEPT) has been used to track the motion of a single radioactively labeled tracer particle within a bed of similar particles. In this paper, the effect of the original event fraction on the results precise in two experiments has been reviewed. Results showed that the algorithm can no longer distinguish some corrupt trajectories, in addition to; further iteration reduces the statistical significance of the sample without improving its quality. Results show that the optimum value of trajectories depends on the type of experiment.

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation.

PubMed

Wasserman, Michael R; Alejo, Jose L; Altman, Roger B; Blanchard, Scott C

2016-04-01

Directional translocation of the ribosome through the mRNA open reading frame is a critical determinant of translational fidelity. This process entails a complex interplay of large-scale conformational changes within the actively translating particle, which together coordinate the movement of tRNA and mRNA substrates with respect to the large and small ribosomal subunits. Using pre-steady state, single-molecule fluorescence resonance energy transfer imaging, we tracked the nature and timing of these conformational events within the Escherichia coli ribosome from five structural perspectives. Our investigations revealed direct evidence of structurally and kinetically distinct late intermediates during substrate movement, whose resolution determines the rate of translocation. These steps involve intramolecular events within the EF-G-GDP-bound ribosome, including exaggerated, reversible fluctuations of the small-subunit head domain, which ultimately facilitate peptidyl-tRNA's movement into its final post-translocation position.

Multi-perspective smFRET reveals rate-determining late intermediates of ribosomal translocation

PubMed Central

Wasserman, Michael R.; Alejo, Jose L.; Altman, Roger B.; Blanchard, Scott C.

2016-01-01

Directional translocation of the ribosome through the messenger RNA open reading frame is a critical determinant of translational fidelity. This process entails a complex interplay of large-scale conformational changes within the actively translating particle, which together coordinate the movement of transfer and messenger RNA substrates with respect to the large and small ribosomal subunits. Using pre-steady state, single-molecule fluorescence resonance energy transfer imaging, we have tracked the nature and timing of these conformational events within the Escherichia coli ribosome from five structural perspectives. Our investigations reveal direct evidence of structurally and kinetically distinct, late intermediates during substrate movement, whose resolution is rate-determining to the translocation mechanism. These steps involve intra-molecular events within the EFG(GDP)-bound ribosome, including exaggerated, reversible fluctuations of the small subunit head domain, which ultimately facilitate peptidyl-tRNA’s movement into its final post-translocation position. PMID:26926435

Seasonal characteristics of water exchange in Beibu Gulf based on a particle tracking model

NASA Astrophysics Data System (ADS)

Wang, L.; Pan, W.; Yan, X.

2016-12-01

A lagrangian particle tracking model coupled with a three-dimensional Marine Environmental Committee Ocean Model (MEC) is used to study the transport and seasonal characteristics of water exchange in Beibu Gulf. The hydrodynamic model (MEC), which is forced with the daily surface and lateral boundary fluxes, as well as tidal harmonics and monthly climatological river discharges, is applied to simulate the flow field in the gulf during 2014. Using these results, particle tracking method which includes tidal advection and random walk in the horizontal is used to determine the residence times of sub regions within the gulf in response of winter and summer wind forcing. The result shows water exchange processes in the gulf have a similar tendency with seasonal circulation structure. During the sourthwestly prevailing wind in summer, water particles are traped within the gulf that considerably increases the residence time of each sub region. On the contrary, the presence of strong northeastly prevailing wind in winter drives particles to move cyclonicly leading to shorter residence times and rather active water exchanges among sub regions. Similarly, particle tracking is applied to investigate the water transport in Beibu Gulf. As Qiongzhou Strait and the wide opening in the south of the gulf are two significant channels connecting with the open ocean, continuous particle releases are simulated to quantify the influence range and the pathways of these sources water flowing into Beibu Gulf. The results show that water particles originated from Qiongzhou Strait are moving westward due to the year-round strong westward flow transportation. Influencing range in the north of the Beibu Gulf is enlarged by winter northeastly wind, however, it is blocked to the Leizhou Peninsula coastal region by summer westly wind. In the south opening, water particles are transported northward into the gulf along Hainan Island and flushed from Vietnam coastal region to the ocean rapidly by the longshore currents.

A complete system for head tracking using motion-based particle filter and randomly perturbed active contour

NASA Astrophysics Data System (ADS)

Bouaynaya, N.; Schonfeld, Dan

2005-03-01

Many real world applications in computer and multimedia such as augmented reality and environmental imaging require an elastic accurate contour around a tracked object. In the first part of the paper we introduce a novel tracking algorithm that combines a motion estimation technique with the Bayesian Importance Sampling framework. We use Adaptive Block Matching (ABM) as the motion estimation technique. We construct the proposal density from the estimated motion vector. The resulting algorithm requires a small number of particles for efficient tracking. The tracking is adaptive to different categories of motion even with a poor a priori knowledge of the system dynamics. Particulary off-line learning is not needed. A parametric representation of the object is used for tracking purposes. In the second part of the paper, we refine the tracking output from a parametric sample to an elastic contour around the object. We use a 1D active contour model based on a dynamic programming scheme to refine the output of the tracker. To improve the convergence of the active contour, we perform the optimization over a set of randomly perturbed initial conditions. Our experiments are applied to head tracking. We report promising tracking results in complex environments.

Multiple hypothesis tracking for cluttered biological image sequences.

PubMed

Chenouard, Nicolas; Bloch, Isabelle; Olivo-Marin, Jean-Christophe

2013-11-01

In this paper, we present a method for simultaneously tracking thousands of targets in biological image sequences, which is of major importance in modern biology. The complexity and inherent randomness of the problem lead us to propose a unified probabilistic framework for tracking biological particles in microscope images. The framework includes realistic models of particle motion and existence and of fluorescence image features. For the track extraction process per se, the very cluttered conditions motivate the adoption of a multiframe approach that enforces tracking decision robustness to poor imaging conditions and to random target movements. We tackle the large-scale nature of the problem by adapting the multiple hypothesis tracking algorithm to the proposed framework, resulting in a method with a favorable tradeoff between the model complexity and the computational cost of the tracking procedure. When compared to the state-of-the-art tracking techniques for bioimaging, the proposed algorithm is shown to be the only method providing high-quality results despite the critically poor imaging conditions and the dense target presence. We thus demonstrate the benefits of advanced Bayesian tracking techniques for the accurate computational modeling of dynamical biological processes, which is promising for further developments in this domain.

Tri-track: free software for large-scale particle tracking.

PubMed

Vallotton, Pascal; Olivier, Sandra

2013-04-01

The ability to correctly track objects in time-lapse sequences is important in many applications of microscopy. Individual object motions typically display a level of dynamic regularity reflecting the existence of an underlying physics or biology. Best results are obtained when this local information is exploited. Additionally, if the particle number is known to be approximately constant, a large number of tracking scenarios may be rejected on the basis that they are not compatible with a known maximum particle velocity. This represents information of a global nature, which should ideally be exploited too. Some time ago, we devised an efficient algorithm that exploited both types of information. The tracking task was reduced to a max-flow min-cost problem instance through a novel graph structure that comprised vertices representing objects from three consecutive image frames. The algorithm is explained here for the first time. A user-friendly implementation is provided, and the specific relaxation mechanism responsible for the method's effectiveness is uncovered. The software is particularly competitive for complex dynamics such as dense antiparallel flows, or in situations where object displacements are considerable. As an application, we characterize a remarkable vortex structure formed by bacteria engaged in interstitial motility.

Statistical and sampling issues when using multiple particle tracking

NASA Astrophysics Data System (ADS)

Savin, Thierry; Doyle, Patrick S.

2007-08-01

Video microscopy can be used to simultaneously track several microparticles embedded in a complex material. The trajectories are used to extract a sample of displacements at random locations in the material. From this sample, averaged quantities characterizing the dynamics of the probes are calculated to evaluate structural and/or mechanical properties of the assessed material. However, the sampling of measured displacements in heterogeneous systems is singular because the volume of observation with video microscopy is finite. By carefully characterizing the sampling design in the experimental output of the multiple particle tracking technique, we derive estimators for the mean and variance of the probes’ dynamics that are independent of the peculiar statistical characteristics. We expose stringent tests of these estimators using simulated and experimental complex systems with a known heterogeneous structure. Up to a certain fundamental limitation, which we characterize through a material degree of sampling by the embedded probe tracking, these estimators can be applied to quantify the heterogeneity of a material, providing an original and intelligible kind of information on complex fluid properties. More generally, we show that the precise assessment of the statistics in the multiple particle tracking output sample of observations is essential in order to provide accurate unbiased measurements.

Particle Tracks in Aerogel

NASA Image and Video Library

2005-11-03

In an experiment using a special air gun, particles are shot into aerogel at high velocities. Closeup of particles leaving a carrot-shaped trail in the aerogel are shown here. Aerogel was used on NASA Stardust spacecraft.

Single nanoparticle tracking spectroscopic microscope

DOEpatents

Yang, Haw [Moraga, CA; Cang, Hu [Berkeley, CA; Xu, Cangshan [Berkeley, CA; Wong, Chung M [San Gabriel, CA

2011-07-19

A system that can maintain and track the position of a single nanoparticle in three dimensions for a prolonged period has been disclosed. The system allows for continuously imaging the particle to observe any interactions it may have. The system also enables the acquisition of real-time sequential spectroscopic information from the particle. The apparatus holds great promise in performing single molecule spectroscopy and imaging on a non-stationary target.

PhotoGate microscopy: tracking single molecules in a cytoplasm (Conference Presentation)

NASA Astrophysics Data System (ADS)

Yildiz, Ahmet

2016-02-01

Tracking single molecules inside cells reveals the dynamics of biological processes, including receptor trafficking, signaling and cargo transport. However, individual molecules often cannot be resolved inside cells due to their high density in the cellular environment. We developed a photobleaching gate assay, which controls the number of fluorescent particles in a region of interest by repeatedly photobleaching its boundary. Using this method, we tracked single particles at surface densities two orders of magnitude higher than the single-molecule detection limit. We observed ligand-induced dimerization of epidermal growth factor receptors (EGFR) on a live cell membrane. In addition, we tracked individual intraflagellar transport (IFT) trains along the length of a cilium and observed their remodeling at the ciliary tip.

First passage times for multiple particles with reversible target-binding kinetics

NASA Astrophysics Data System (ADS)

Grebenkov, Denis S.

2017-10-01

We investigate the first passage problem for multiple particles that diffuse towards a target, partially adsorb there, and then desorb after a finite exponentially distributed residence time. We search for the first time when m particles undergoing such reversible target-binding kinetics are found simultaneously on the target that may trigger an irreversible chemical reaction or a biophysical event. Even if the particles are independent, the finite residence time on the target yields an intricate temporal coupling between particles. We compute analytically the mean first passage time (MFPT) for two independent particles by mapping the original problem to higher-dimensional surface-mediated diffusion and solving the coupled partial differential equations. The respective effects of the adsorption and desorption rates on the MFPT are revealed and discussed.

Nanoparticle Tracking Analysis for Determination of Hydrodynamic Diameter, Concentration, and Zeta-Potential of Polyplex Nanoparticles.

PubMed

Wilson, David R; Green, Jordan J

2017-01-01

Nanoparticle tracking analysis (NTA) is a recently developed nanoparticle characterization technique that offers certain advantages over dynamic light scattering for characterizing polyplex nanoparticles in particular. Dynamic light scattering results in intensity-weighted average measurements of nanoparticle characteristics. In contrast, NTA directly tracks individual particles, enabling concentration measurements as well as the direct determination of number-weighted particle size and zeta-potential. A direct number-weighted assessment of nanoparticle characteristics is particularly useful for polydisperse samples of particles, including many varieties of gene delivery particles that can be prone to aggregation. Here, we describe the synthesis of poly(beta-amino ester)/deoxyribonucleic acid (PBAE/DNA) polyplex nanoparticles and their characterization using NTA to determine hydrodynamic diameter, zeta-potential, and concentration. Additionally, we detail methods of labeling nucleic acids with fluorophores to assess only those polyplex nanoparticles containing plasmids via NTA. Polymeric gene delivery of exogenous plasmid DNA has great potential for treating a wide variety of diseases by inducing cells to express a gene of interest.

Spirit Leaves Telling Tracks

NASA Technical Reports Server (NTRS)

2004-01-01

Scientists have found clues about the nature of martian soil through analyzing wheel marks from the Mars Exploration Rover Spirit in this image. The image was taken by Spirit's rear hazard-identification camera just after the rover drove approximately 1 meter (3 feet) northwest off the Columbia Memorial Station (lander platform) early Thursday morning. That the wheel tracks are shallow indicates the soil has plenty of strength to support the moving rover. The well-defined track characteristics suggest the presence of very fine particles in the martian soil (along with larger particles). Scientists also think the soil may have some cohesive properties.

Surrogate-driven deformable motion model for organ motion tracking in particle radiation therapy

NASA Astrophysics Data System (ADS)

Fassi, Aurora; Seregni, Matteo; Riboldi, Marco; Cerveri, Pietro; Sarrut, David; Battista Ivaldi, Giovanni; Tabarelli de Fatis, Paola; Liotta, Marco; Baroni, Guido

2015-02-01

The aim of this study is the development and experimental testing of a tumor tracking method for particle radiation therapy, providing the daily respiratory dynamics of the patient’s thoraco-abdominal anatomy as a function of an external surface surrogate combined with an a priori motion model. The proposed tracking approach is based on a patient-specific breathing motion model, estimated from the four-dimensional (4D) planning computed tomography (CT) through deformable image registration. The model is adapted to the interfraction baseline variations in the patient’s anatomical configuration. The driving amplitude and phase parameters are obtained intrafractionally from a respiratory surrogate signal derived from the external surface displacement. The developed technique was assessed on a dataset of seven lung cancer patients, who underwent two repeated 4D CT scans. The first 4D CT was used to build the respiratory motion model, which was tested on the second scan. The geometric accuracy in localizing lung lesions, mediated over all breathing phases, ranged between 0.6 and 1.7 mm across all patients. Errors in tracking the surrounding organs at risk, such as lungs, trachea and esophagus, were lower than 1.3 mm on average. The median absolute variation in water equivalent path length (WEL) within the target volume did not exceed 1.9 mm-WEL for simulated particle beams. A significant improvement was achieved compared with error compensation based on standard rigid alignment. The present work can be regarded as a feasibility study for the potential extension of tumor tracking techniques in particle treatments. Differently from current tracking methods applied in conventional radiotherapy, the proposed approach allows for the dynamic localization of all anatomical structures scanned in the planning CT, thus providing complete information on density and WEL variations required for particle beam range adaptation.

Modeling Sediment Transport Using a Lagrangian Particle Tracking Algorithm Coupled with High-Resolution Large Eddy Simulations: a Critical Analysis of Model Limits and Sensitivity

NASA Astrophysics Data System (ADS)

Garcia, M. H.

2016-12-01

Modeling Sediment Transport Using a Lagrangian Particle Tracking Algorithm Coupled with High-Resolution Large Eddy Simulations: a Critical Analysis of Model Limits and Sensitivity Som Dutta1, Paul Fischer2, Marcelo H. Garcia11Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, Il, 61801 2Department of Computer Science and Department of MechSE, University of Illinois at Urbana-Champaign, Urbana, Il, 61801 Since the seminal work of Niño and Garcia [1994], one-way coupled Lagrangian particle tracking has been used extensively for modeling sediment transport. Over time, the Lagrangian particle tracking method has been coupled with Eulerian flow simulations, ranging from Reynolds Averaged Navier-Stokes (RANS) based models to Detached Eddy Simulations (DES) [Escauriaza and Sotiropoulos, 2011]. Advent of high performance computing (HPC) platforms and faster algorithms have resulted in the work of Dutta et al. [2016], where Lagrangian particle tracking was coupled with high-resolution Large Eddy Simulations (LES) to model the complex and highly non-linear phenomenon of Bulle-Effect at diversions. Despite all the advancements in using Lagrangian particle tracking, there has not been a study that looks in detail at the limits of the model in the context of sediment transport, and also analyzes the sensitivity of the various force formulation in the force balance equation of the particles. Niño and Garcia [1994] did a similar analysis, but the vertical flow velocity distribution was modeled as the log-law. The current study extends the analysis by modeling the flow using high-resolution LES at a Reynolds number comparable to experiments of Niño et al. [1994]. Dutta et al., (2016), Large Eddy Simulation (LES) of flow and bedload transport at an idealized 90-degree diversion: insight into Bulle-Effect, River Flow 2016 - Constantinescu, Garcia & Hanes (Eds), Taylor & Francis Group, London, 101-109. Escauriaza and Sotiropoulos, (2011), Lagrangian model of bed-load transport in turbulent junction flows, Journal of Fluid Mechanics, 666,36-76. Niño and García, (1994), Gravel saltation: 2. Modeling, Water Resources Research, 30(6),1915-1924. Niño et al., (1994), Gravel saltation: 1. Experiments, Water Resources Research, 30(6), 1907-1914.

Out-of-Equilibrium Dynamics of Colloidal Particles at Interfaces

NASA Astrophysics Data System (ADS)

Wang, Anna

It is widely assumed that when colloidal particles adsorb to a fluid-fluid interface, they reach equilibrium rapidly. Recently, however, Kaz et al. [Nature Materials, 11, 138-142 (2012)] found that a variety of functionalised latex microspheres breaching an aqueous phase-oil interface relax logarithmically with time toward equilibrium. The relaxation is so slow that the time projected for the particles to reach the equilibrium contact angle of 110° is months--far longer than typical experimental timescales. In this thesis, we seek to understand the out-of-equilibrium behaviour of particles near interfaces. Because contact line pinning is likely an extra source of dissipation at interfaces, we start with experiments to elucidate the origins of contact-line pinning and find that polymer hairs on aqueous dispersed polymer particles strongly pin the contact-line. For particles without polymer hairs, nanoscale surface roughness can also pin the contact-line, though with a lower energy. We then extend our digital holography capabilities to track non-spherical particles. We demonstrate that we can track the centre-of-mass of a colloidal spherocylinder to a precision of 35 nm in all three dimensions and its orientation to a precision of 1.5°. Furthermore, the measured translational and rotational diffusion coefficients for the spherocylinders agree with hydrodynamic predictions to within 0.3%. This new functionality enables us to track colloidal ellipsoids and spherocylinders as they breach interfaces. By comparing the adsorption trajectories of the non-spherical particles to what is predicted from energy minimisation, we learn that contact-line pinning affects not just the timescales of breaching, but also the pathway to equilibrium. In fact, a particle's path to equilibrium can have complications even before the particle breaches the interface. Some particles are attracted to the interface, but stay within a few nanometers without ever breaching. We refer to this binding-mode as 'non-capillary binding', and we investigate when this binding mode is present, what causes it, and how interparticle interactions depend on the binding mode. The last few chapters in this thesis are extensions of ideas developed in the first part. We track the run and tumble of E.coli to demonstrate the potential of digital holographic microscopy as an imaging tool for active particles. Taking all of the particle-interface literature into account, we also outline some simple design principles for making particle-stabilised Pickering emulsions.

Four-Component Catalytic Machinery: Reversible Three-State Control of Organocatalysis by Walking Back and Forth on a Track.

PubMed

Mittal, Nikita; Özer, Merve S; Schmittel, Michael

2018-04-02

A three-component supramolecular walker system is presented where a two-footed ligand (biped) walks back and forth on a tetrahedral 3D track upon the addition and removal of copper(I) ions, respectively. The addition of N-methylpyrrolidine as a catalyst to the walker system generates a four-component catalytic machinery, which acts as a three-state switchable catalytic ensemble in the presence of substrates for a conjugate addition. The copper(I)-ion-initiated walking process of the biped ligand on the track regulates the catalytic activity in three steps: ON versus int ON (intermediate ON) versus OFF. To establish the operation of the four-component catalytic machinery in a mixture of all constituents, forward and backward cycles were performed in situ illustrating that both the walking process and catalytic action are fully reversible and reproducible.

Observed aerosol effects on marine cloud nucleation and supersaturation

NASA Astrophysics Data System (ADS)

Russell, Lynn M.; Sorooshian, Armin; Seinfeld, John H.; Albrecht, Bruce A.; Nenes, Athanasios; Leaitch, W. Richard; Macdonald, Anne Marie; Ahlm, Lars; Chen, Yi-Chun; Coggon, Matthew; Corrigan, Ashley; Craven, Jill S.; Flagan, Richard C.; Frossard, Amanda A.; Hawkins, Lelia N.; Jonsson, Haflidi; Jung, Eunsil; Lin, Jack J.; Metcalf, Andrew R.; Modini, Robin; Mülmenstädt, Johannes; Roberts, Greg C.; Shingler, Taylor; Song, Siwon; Wang, Zhen; Wonaschütz, Anna

2013-05-01

Aerosol particles in the marine boundary layer include primary organic and salt particles from sea spray and combustion-derived particles from ships and coastal cities. These particle types serve as nuclei for marine cloud droplet activation, although the particles that activate depend on the particle size and composition as well as the supersaturation that results from cloud updraft velocities. The Eastern Pacific Emitted Aerosol Cloud Experiment (EPEACE) 2011 was a targeted aircraft campaign to assess how different particle types nucleate cloud droplets. As part of E-PEACE 2011, we studied the role of marine particles as cloud droplet nuclei and used emitted particle sources to separate particle-induced feedbacks from dynamical variability. The emitted particle sources included shipboard smoke-generated particles with 0.05-1 μm diameters (which produced tracks measured by satellite and had drop composition characteristic of organic smoke) and combustion particles from container ships with 0.05-0.2 μm diameters (which were measured in a variety of conditions with droplets containing both organic and sulfate components) [1]. Three central aspects of the collaborative E-PEACE results are: (1) the size and chemical composition of the emitted smoke particles compared to ship-track-forming cargo ship emissions as well as background marine particles, with particular attention to the role of organic particles, (2) the characteristics of cloud track formation for smoke and cargo ships, as well as the role of multi-layered low clouds, and (3) the implications of these findings for quantifying aerosol indirect effects. For comparison with the E-PEACE results, the preliminary results of the Stratocumulus Observations of Los-Angeles Emissions Derived Aerosol-Droplets (SOLEDAD) 2012 provided evidence of the cloud-nucleating roles of both marine organic particles and coastal urban pollution, with simultaneous measurements of the effective supersaturations of the clouds in the California coastal region.

Historical Building Stability Monitoring by Means of a Cosmic Ray Tracking System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zenoni, Aldo; INFN Sezione di Pavia, Via Bassi 6, 27100 Pavia

Cosmic ray radiation is mostly composed, at sea level, by high energy muons, which are highly penetrating particles capable of crossing kilometers of rock. The ubiquitous and steady presence at the Earth's surface and the high penetration capability have motivated the use of cosmic ray radiation also in fields beyond particle physics, from geology, archaeology, speleology to industrial applications and homeland security. In particular, in recent years, the novel technique of muon tomography has been proposed, with the aim of performing non invasive inspection of large non accessible volumes, material atomic number Z and density discrimination, and three dimension imagemore » reconstruction of the inspected volume. In the present paper, after a short recall of the physical principles and mathematical formalism on which muon tomography is based, a number of examples of application of the novel technique in industry and homeland security issues is given. Moreover, a new application of cosmic rays detection techniques in the field of civil engineering is proposed. The aim is the monitoring of the stability of large structures, in particular the static monitoring of historical buildings, where conservation constraints are more severe and the time evolution of the deformation phenomena under study may be of the order of months or years. The new technique may be seen, in some way, as the reverse problem of muon tomography. As a significant case study, the monitoring of the wooden vaulted roof of the Palazzo della Loggia in the town of Brescia, in Italy, has been considered. The feasibility as well as the performances and limitations of a monitoring system based on cosmic ray tracking have been studied by Monte Carlo simulation and discussed in comparison with more traditional monitoring systems. (authors)« less

Performance analysis of a new positron camera geometry for high speed, fine particle tracking

NASA Astrophysics Data System (ADS)

Sovechles, J. M.; Boucher, D.; Pax, R.; Leadbeater, T.; Sasmito, A. P.; Waters, K. E.

2017-09-01

A new positron camera arrangement was assembled using 16 ECAT951 modular detector blocks. A closely packed, cross pattern arrangement was selected to produce a highly sensitive cylindrical region for tracking particles with low activities and high speeds. To determine the capabilities of this system a comprehensive analysis of the tracking performance was conducted to determine the 3D location error and location frequency as a function of tracer activity and speed. The 3D error was found to range from 0.54 mm for a stationary particle, consistent for all tracer activities, up to 4.33 mm for a tracer with an activity of 3 MBq and a speed of 4 m · s-1. For lower activity tracers (<10-2 MBq), the error was more sensitive to increases in speed, increasing to 28 mm (at 4 m · s-1), indicating that at these conditions a reliable trajectory is not possible. These results expanded on, but correlated well with, previous literature that only contained location errors for tracer speeds up to 1.5 m · s-1. The camera was also used to track directly activated mineral particles inside a two-inch hydrocyclone and a 142 mm diameter flotation cell. A detailed trajectory, inside the hydrocyclone, of a  -212  +  106 µm (10-1 MBq) quartz particle displayed the expected spiralling motion towards the apex. This was the first time a mineral particle of this size had been successfully traced within a hydrocyclone, however more work is required to develop detailed velocity fields.

Proton induced target fragmentation studies on solid state nuclear track detectors using Carbon radiators

NASA Astrophysics Data System (ADS)

Szabó, J.; Pálfalvi, J. K.; Strádi, A.; Bilski, P.; Swakoń, J.; Stolarczyk, L.

2018-04-01

One of the limiting factors of an astronaut's career is the dose received from space radiation. High energy protons, being the main components of the complex radiation field present on a spacecraft, give a significant contribution to the dose. To investigate the behavior of solid state nuclear track detectors (SSNTDs) if they are irradiated by such particles, SSNTD stacks containing carbon blocks were exposed to high energy proton beams (70, 100, 150 and 230 MeV) at the Proteus cyclotron, IFJ PAN -Krakow. The incident protons cannot be detected directly; however, tracks of secondary particles, recoils and fragments of the constituent atoms of the detector material and of the carbon radiator are formed. It was found that as the proton energy increases, the number of tracks induced in the PADC material by secondary particles decreases. From the measured geometrical parameters of the tracks the linear energy transfer (LET) spectrum and the dosimetric quantities were determined, applying appropriate calibration. In the LET spectra the LET range of the most important secondary particles could be identified and their abundance showed differences in the spectra if the detectors were short or long etched. The LET spectra obtained on the SSNTDs irradiated by protons were compared to LET spectra of detectors flown on the International Space Station (ISS): they were quite similar, resulting in a quality factor difference of only 5%. Thermoluminescent detectors (TLDs) were applied in each case to measure the dose from primary protons and other lower LET particles present in space. Comparing and analyzing the results of the TLD and SSNTD measurements, it was obtained that proton induced target fragments contributed to the total absorbed dose in 3.2% and to the dose equivalent in 14.2% in this particular space experiment.

Dispersion Analysis Using Particle Tracking Simulations Through Heterogeneity Based on Outcrop Lidar Imagery

NASA Astrophysics Data System (ADS)

Klise, K. A.; Weissmann, G. S.; McKenna, S. A.; Tidwell, V. C.; Frechette, J. D.; Wawrzyniec, T. F.

2007-12-01

Solute plumes are believed to disperse in a non-Fickian manner due to small-scale heterogeneity and variable velocities that create preferential pathways. In order to accurately predict dispersion in naturally complex geologic media, the connection between heterogeneity and dispersion must be better understood. Since aquifer properties can not be measured at every location, it is common to simulate small-scale heterogeneity with random field generators based on a two-point covariance (e.g., through use of sequential simulation algorithms). While these random fields can produce preferential flow pathways, it is unknown how well the results simulate solute dispersion through natural heterogeneous media. To evaluate the influence that complex heterogeneity has on dispersion, we utilize high-resolution terrestrial lidar to identify and model lithofacies from outcrop for application in particle tracking solute transport simulations using RWHet. The lidar scan data are used to produce a lab (meter) scale two-dimensional model that captures 2-8 mm scale natural heterogeneity. Numerical simulations utilize various methods to populate the outcrop structure captured by the lidar-based image with reasonable hydraulic conductivity values. The particle tracking simulations result in residence time distributions used to evaluate the nature of dispersion through complex media. Particle tracking simulations through conductivity fields produced from the lidar images are then compared to particle tracking simulations through hydraulic conductivity fields produced from sequential simulation algorithms. Based on this comparison, the study aims to quantify the difference in dispersion when using realistic and simplified representations of aquifer heterogeneity. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

The constant displacement scheme for tracking particles in heterogeneous aquifers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wen, X.H.; Gomez-Hernandez, J.J.

1996-01-01

Simulation of mass transport by particle tracking or random walk in highly heterogeneous media may be inefficient from a computational point of view if the traditional constant time step scheme is used. A new scheme which adjusts automatically the time step for each particle according to the local pore velocity, so that each particle always travels a constant distance, is shown to be computationally faster for the same degree of accuracy than the constant time step method. Using the constant displacement scheme, transport calculations in a 2-D aquifer model, with nature log-transmissivity variance of 4, can be 8.6 times fastermore » than using the constant time step scheme.« less

Real time tracking by LOPF algorithm with mixture model

NASA Astrophysics Data System (ADS)

Meng, Bo; Zhu, Ming; Han, Guangliang; Wu, Zhiguo

2007-11-01

A new particle filter-the Local Optimum Particle Filter (LOPF) algorithm is presented for tracking object accurately and steadily in visual sequences in real time which is a challenge task in computer vision field. In order to using the particles efficiently, we first use Sobel algorithm to extract the profile of the object. Then, we employ a new Local Optimum algorithm to auto-initialize some certain number of particles from these edge points as centre of the particles. The main advantage we do this in stead of selecting particles randomly in conventional particle filter is that we can pay more attentions on these more important optimum candidates and reduce the unnecessary calculation on those negligible ones, in addition we can overcome the conventional degeneracy phenomenon in a way and decrease the computational costs. Otherwise, the threshold is a key factor that affecting the results very much. So here we adapt an adaptive threshold choosing method to get the optimal Sobel result. The dissimilarities between the target model and the target candidates are expressed by a metric derived from the Bhattacharyya coefficient. Here, we use both the counter cue to select the particles and the color cur to describe the targets as the mixture target model. The effectiveness of our scheme is demonstrated by real visual tracking experiments. Results from simulations and experiments with real video data show the improved performance of the proposed algorithm when compared with that of the standard particle filter. The superior performance is evident when the target encountering the occlusion in real video where the standard particle filter usually fails.

Automated Track Recognition and Event Reconstruction in Nuclear Emulsion

NASA Technical Reports Server (NTRS)

Deines-Jones, P.; Cherry, M. L.; Dabrowska, A.; Holynski, R.; Jones, W. V.; Kolganova, E. D.; Kudzia, D.; Nilsen, B. S.; Olszewski, A.; Pozharova, E. A.;

Current reversals and metastable states in the infinite Bose-Hubbard chain with local particle loss

NASA Astrophysics Data System (ADS)

Kiefer-Emmanouilidis, M.; Sirker, J.

2017-12-01

We present an algorithm which combines the quantum trajectory approach to open quantum systems with a density-matrix renormalization-group scheme for infinite one-dimensional lattice systems. We apply this method to investigate the long-time dynamics in the Bose-Hubbard model with local particle loss starting from a Mott-insulating initial state with one boson per site. While the short-time dynamics can be described even quantitatively by an equation of motion (EOM) approach at the mean-field level, many-body interactions lead to unexpected effects at intermediate and long times: local particle currents far away from the dissipative site start to reverse direction ultimately leading to a metastable state with a total particle current pointing away from the lossy site. An alternative EOM approach based on an effective fermion model shows that the reversal of currents can be understood qualitatively by the creation of holon-doublon pairs at the edge of the region of reduced particle density. The doublons are then able to escape while the holes move towards the dissipative site, a process reminiscent—in a loose sense—of Hawking radiation.

Some cosmic radiation dose measurements aboard flights connecting Zagreb Airport.

PubMed

Vuković, B; Radolić, V; Lisjak, I; Vekić, B; Poje, M; Planinić, J

2008-02-01

When primary particles from space, mainly protons, enter the atmosphere, they produce interactions with air nuclei, and cosmic-ray showers are induced. The radiation field at aircraft altitude is complex, with different types of particles, mainly photons, electrons, positrons and neutrons, with a large energy range. The non-neutron component of cosmic radiation dose aboard A320 and ATR40 aircraft was measured with TLD-100 (LiF:Mg,Ti) detectors and the Mini 6100 semiconductor dosimeter; the neutron dose was measured with the neutron dosimeter consisted of LR-115 track detector and boron foil BN-1 or 10B converter. The estimated occupational effective dose for the aircraft crew (A320) working 500 h per year was 1.64 mSv. Another experiment was performed at the flights Zagreb-Paris-Buenos Aires and reversely, when one measured non-neutron cosmic radiation dose; for 26.7 h of flight, the MINI 6100 dosimeter gave an average dose rate of 2.3 microSv/h and the TLD dosimeter registered the dose equivalent of 75 microSv or the average dose rate of 2.7 microSv/h; the neutron dosimeter gave the dose rate of 2.4 microSv/h. In the same month, February 2005, a traveling to Japan (24-h-flight: Zagreb-Frankfurt-Tokyo and reversely) and the TLD-100 measurement showed the average dose rate of 2.4microSv/h; the neutron dosimeter gave the dose rate of 2.5 microSv/h. Comparing dose rates of the non-neutron component (low LET) and the neutron one (high LET) of the radiation field at the aircraft flight level, we could conclude that the neutron component carried about 50% of the total dose, that was near other known data.

Parallel computing of a digital hologram and particle searching for microdigital-holographic particle-tracking velocimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Satake, Shin-ichi; Kanamori, Hiroyuki; Kunugi, Tomoaki

2007-02-01

We have developed a parallel algorithm for microdigital-holographic particle-tracking velocimetry. The algorithm is used in (1) numerical reconstruction of a particle image computer using a digital hologram, and (2) searching for particles. The numerical reconstruction from the digital hologram makes use of the Fresnel diffraction equation and the FFT (fast Fourier transform),whereas the particle search algorithm looks for local maximum graduation in a reconstruction field represented by a 3D matrix. To achieve high performance computing for both calculations (reconstruction and particle search), two memory partitions are allocated to the 3D matrix. In this matrix, the reconstruction part consists of horizontallymore » placed 2D memory partitions on the x-y plane for the FFT, whereas, the particle search part consists of vertically placed 2D memory partitions set along the z axes.Consequently, the scalability can be obtained for the proportion of processor elements,where the benchmarks are carried out for parallel computation by a SGI Altix machine.« less

Stream interfaces and energetic ions 2: Ulysses test of Pioneer results

NASA Technical Reports Server (NTRS)

Intriligator, Devrie S.; Siscoe, George L.; Wibberez, Gerd; Kunow, Horst; Gosling, John T.

1995-01-01

Ulysses measurements of energetic and solar wind particles taken near 5 AU between 20 and 30 degrees south latitude during a well-developed recurring corotating interaction region (CIR) show that the CIR's corotating energetic ion population (CEIP) associated with the trailing reverse shock starts within the CIR at the stream interface. This is consistent with an earlier result obtained by Pioneers 10 and 11 in the ecliptic plane between 4 and 6 AU. The Ulysses/Pioneer finding noteworthy since the stream interface is not magnetically connected to the reverse shock but lies 12-17 corotation hours from it. Thus, the finding to be inconsistent with the basic model that generates CEIP particles at the reverse shock and propagates them along field lines Eliminating the inconsistency probably entails an extension of the standard model. We consider two possible extensions cross-field diffusion and energetic particles generation closer to the sun in the gap between the stream interface and the reverse shock.

Is the gas-particle partitioning in alpha-pinene secondary organic aerosol reversible?

NASA Astrophysics Data System (ADS)

Grieshop, Andrew P.; Donahue, Neil M.; Robinson, Allen L.

2007-07-01

This paper discusses the reversibility of gas-particle partitioning in secondary organic aerosol (SOA) formed from α-pinene ozonolysis in a smog chamber. Previously, phase partitioning has been studied quantitatively via SOA production experiments and qualitatively by perturbing temperature and observing particle evaporation. In this work, two methods were used to isothermally dilute the SOA: an external dilution sampler and an in-chamber technique. Dilution caused some evaporation of SOA, but repartitioning took place on a time scale of tens of minutes to hours-consistent with an uptake coefficient on the order of 0.001-0.01. However, given sufficient time, α-pinene SOA repartitions reversibly based on comparisons with data from conventional SOA yield experiments. Further, aerosol mass spectrometer (AMS) data indicate that the composition of SOA varies with partitioning. These results suggest that oligomerization observed in high-concentration laboratory experiments may be a reversible process and underscore the complexity of the kinetics of formation and evaporation of SOA.

The energetic ion signature of an O-type neutral line in the geomagnetic tail

NASA Technical Reports Server (NTRS)

Martin, R. F., Jr.; Johnson, D. F.; Speiser, T. W.

1991-01-01

An energetic ion signature is presented which has the potential for remote sensing of an O-type neutral line embedded in a current sheet. A source plasma with a tailward flowing Kappa distribution yields a strongly non-Kappa distribution after interacting with the neutral line: sharp jumps, or ridges, occur in the velocity space distribution function f(nu-perpendicular, nu-parallel) associated with both increases and decreases in f. The jumps occur when orbits are reversed in the x-direction: a reversal causing initially earthward particles (low probability in the source distribution) to be observed results in a decrease in f, while a reversal causing initially tailward particles to be observed produces an increase in f. The reversals, and hence the jumps, occur at approximately constant values of perpendicular velocity in both the positive nu parallel and negative nu parallel half planes. The results were obtained using single particle simulations in a fixed magnetic field model.

Revised Extended Grid Library

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martz, Roger L.

The Revised Eolus Grid Library (REGL) is a mesh-tracking library that was developed for use with the MCNP6TM computer code so that (radiation) particles can track on an unstructured mesh. The unstructured mesh is a finite element representation of any geometric solid model created with a state-of-the-art CAE/CAD tool. The mesh-tracking library is written using modern Fortran and programming standards; the library is Fortran 2003 compliant. The library was created with a defined application programmer interface (API) so that it could easily integrate with other particle tracking/transport codes. The library does not handle parallel processing via the message passing interfacemore » (mpi), but has been used successfully where the host code handles the mpi calls. The library is thread-safe and supports the OpenMP paradigm. As a library, all features are available through the API and overall a tight coupling between it and the host code is required. Features of the library are summarized with the following list: Can accommodate first and second order 4, 5, and 6-sided polyhedra; any combination of element types may appear in a single geometry model; parts may not contain tetrahedra mixed with other element types; pentahedra and hexahedra can be together in the same part; robust handling of overlaps and gaps; tracks element-to-element to produce path length results at the element level; finds element numbers for a given mesh location; finds intersection points on element faces for the particle tracks; produce a data file for post processing results analysis; reads Abaqus .inp input (ASCII) files to obtain information for the global mesh-model; supports parallel input processing via mpi; and support parallel particle transport by both mpi and OpenMP.« less

Interactive, computer-assisted tracking of speckle trajectories in fluorescence microscopy: application to actin polymerization and membrane fusion.

PubMed

Smith, Matthew B; Karatekin, Erdem; Gohlke, Andrea; Mizuno, Hiroaki; Watanabe, Naoki; Vavylonis, Dimitrios

2011-10-05

Analysis of particle trajectories in images obtained by fluorescence microscopy reveals biophysical properties such as diffusion coefficient or rates of association and dissociation. Particle tracking and lifetime measurement is often limited by noise, large mobilities, image inhomogeneities, and path crossings. We present Speckle TrackerJ, a tool that addresses some of these challenges using computer-assisted techniques for finding positions and tracking particles in different situations. A dynamic user interface assists in the creation, editing, and refining of particle tracks. The following are results from application of this program: 1), Tracking single molecule diffusion in simulated images. The shape of the diffusing marker on the image changes from speckle to cloud, depending on the relationship of the diffusion coefficient to the camera exposure time. We use these images to illustrate the range of diffusion coefficients that can be measured. 2), We used the program to measure the diffusion coefficient of capping proteins in the lamellipodium. We found values ∼0.5 μm(2)/s, suggesting capping protein association with protein complexes or the membrane. 3), We demonstrate efficient measuring of appearance and disappearance of EGFP-actin speckles within the lamellipodium of motile cells that indicate actin monomer incorporation into the actin filament network. 4), We marked appearance and disappearance events of fluorescently labeled vesicles to supported lipid bilayers and tracked single lipids from the fused vesicle on the bilayer. This is the first time, to our knowledge, that vesicle fusion has been detected with single molecule sensitivity and the program allowed us to perform a quantitative analysis. 5), By discriminating between undocking and fusion events, dwell times for vesicle fusion after vesicle docking to membranes can be measured. Copyright © 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Single-virus tracking approach to reveal the interaction of Dengue virus with autophagy during the early stage of infection

NASA Astrophysics Data System (ADS)

Chu, Li-Wei; Huang, Yi-Lung; Lee, Jin-Hui; Huang, Long-Ying; Chen, Wei-Jun; Lin, Ya-Hsuan; Chen, Jyun-Yu; Xiang, Rui; Lee, Chau-Hwang; Ping, Yueh-Hsin

2014-01-01

Dengue virus (DENV) is one of the major infectious pathogens worldwide. DENV infection is a highly dynamic process. Currently, no antiviral drug is available for treating DENV-induced diseases since little is known regarding how the virus interacts with host cells during infection. Advanced molecular imaging technologies are powerful tools to understand the dynamics of intracellular interactions and molecular trafficking. This study exploited a single-virus particle tracking technology to address whether DENV interacts with autophagy machinery during the early stage of infection. Using confocal microscopy and three-dimensional image analysis, we showed that DENV triggered the formation of green fluorescence protein-fused microtubule-associated protein 1A/1B-light chain 3 (GFP-LC3) puncta, and DENV-induced autophagosomes engulfed DENV particles within 15-min postinfection. Moreover, single-virus particle tracking revealed that both DENV particles and autophagosomes traveled together during the viral infection. Finally, in the presence of autophagy suppressor 3-methyladenine, the replication of DENV was inhibited and the location of DENV particles spread in cytoplasma. In contrast, the numbers of newly synthesized DENV were elevated and the co-localization of DENV particles and autophagosomes was detected while the cells were treated with autophagy inducer rapamycin. Taken together, we propose that DENV particles interact with autophagosomes at the early stage of viral infection, which promotes the replication of DENV.

Effects of cooling rate on particle rearrangement statistics: Rapidly cooled glasses are more ductile and less reversible.

PubMed

Fan, Meng; Wang, Minglei; Zhang, Kai; Liu, Yanhui; Schroers, Jan; Shattuck, Mark D; O'Hern, Corey S

2017-02-01

Amorphous solids, such as metallic, polymeric, and colloidal glasses, display complex spatiotemporal response to applied deformations. In contrast to crystalline solids, during loading, amorphous solids exhibit a smooth crossover from elastic response to plastic flow. In this study, we investigate the mechanical response of binary Lennard-Jones glasses to athermal, quasistatic pure shear as a function of the cooling rate used to prepare them. We find several key results concerning the connection between strain-induced particle rearrangements and mechanical response. We show that the energy loss per strain dU_{loss}/dγ caused by particle rearrangements for more rapidly cooled glasses is larger than that for slowly cooled glasses. We also find that the cumulative energy loss U_{loss} can be used to predict the ductility of glasses even in the putative linear regime of stress versus strain. U_{loss} increases (and the ratio of shear to bulk moduli decreases) with increasing cooling rate, indicating enhanced ductility. In addition, we characterized the degree of reversibility of particle motion during a single shear cycle. We find that irreversible particle motion occurs even in the linear regime of stress versus strain. However, slowly cooled glasses, which undergo smaller rearrangements, are more reversible during a single shear cycle than rapidly cooled glasses. Thus, we show that more ductile glasses are also less reversible.

A Long Terminal Repeat-Containing Retrotransposon of Schizosaccharomyces pombe Expresses a Gag-Like Protein That Assembles into Virus-Like Particles Which Mediate Reverse Transcription

PubMed Central

Teysset, Laure; Dang, Van-Dinh; Kim, Min Kyung; Levin, Henry L.

2003-01-01

The Tf1 element of Schizosaccharomyces pombe is a long terminal repeat-containing retrotransposon that encodes functional protease, reverse transcriptase, and integrase proteins. Although these proteins are known to be necessary for protein processing, reverse transcription, and integration, respectively, the function of the protein thought to be Gag has not been determined. We present here the first electron microscopy of Tf1 particles. We tested whether the putative Gag of Tf1 was required for particle formation, packaging of RNA, and reverse transcription. We generated deletions of 10 amino acids in each of the four hydrophilic domains of the protein and found that all four mutations reduced transposition activity. The N-terminal deletion removed a nuclear localization signal and inhibited nuclear import of the transposon. The two mutations in the center of Gag destabilized the protein and resulted in no virus-like particles. The C-terminal deletion caused a defect in RNA packaging and, as a result, low levels of cDNA. The electron microscopy of cells expressing a truncated Tf1 showed that Gag alone was sufficient for the formation of virus-like particles. Taken together, these results indicate that Tf1 encodes a Gag protein that is a functional equivalent of the Gag proteins of retroviruses. PMID:12692246

Comparison of three-dimensional particle tracking and sizing using plenoptic imaging and digital in-line holography

DOE PAGES

Hall, Elise M.; Thurow, Brian S.; Guildenbecher, Daniel R.

2016-08-08

Digital in-line holography (DIH) and plenoptic photography are two techniques for single-shot, volumetric measurement of 3D particle fields. Here we present a comparison of the two methods by applying plenoptic imaging to experimental configurations that have been previously investigated with DIH. These experiments include the tracking of secondary droplets from the impact of a water drop on a thin film of water and tracking of pellets from a shotgun. Both plenoptic imaging and DIH successfully quantify the 3D nature of these particle fields. Furthermore, this includes measurement of the 3D particle position, individual particle sizes, and three-component velocity vectors. Formore » the initial processing methods presented here, both techniques give out-of-plane positional accuracy of approximately 1–2 particle diameters. For a fixed image sensor, digital holography achieves higher effective in-plane spatial resolutions. However, collimated and coherent illumination makes holography susceptible to image distortion through index of refraction gradients, as demonstrated in the shotgun experiments. In contrast, plenoptic imaging allows for a simpler experimental configuration and, due to the use of diffuse, white-light illumination, plenoptic imaging is less susceptible to image distortion in the shotgun experiments.« less

Track Structure and the Biological Effectiveness of Accelerated Particles for the Induction of Chromosome Damage

NASA Technical Reports Server (NTRS)

George, K.; Hada, M.; Chappell, L.; Cucinotta, F. A.

2011-01-01

Track structure models predict that at a fixed value of LET, particles with lower charge number, Z will have a higher biological effectiveness compared to particles with a higher Z. In this report we investigated how track structure effects induction of chromosomal aberration in human cells. Human lymphocytes were irradiated in vitro with various energies of accelerated iron, silicon, neon, or titanium ions and chromosome damage was assessed in using three color FISH chromosome painting in chemically induced PCC samples collected a first cell division post irradiation. The LET values for these ions ranged from 30 to195 keV/micron. Of the particles studied, Neon ions have the highest biological effectiveness for induction of total chromosome damage, which is consistent with track structure model predictions. For complex-type exchanges 64 MeV/ u Neon and 450 MeV/u Iron were equally effective and induced the most complex damage. In addition we present data on chromosomes exchanges induced by six different energies of protons (5 MeV/u to 2.5 GeV/u). The linear dose response term was similar for all energies of protons suggesting that the effect of the higher LET at low proton energies is balanced by the production of nuclear secondaries from the high energy protons.

Comparison of particle-tracking and lumped-parameter age-distribution models for evaluating vulnerability of production wells to contamination

USGS Publications Warehouse

Eberts, S.M.; Böhlke, J.K.; Kauffman, L.J.; Jurgens, B.C.

2012-01-01

Environmental age tracers have been used in various ways to help assess vulnerability of drinking-water production wells to contamination. The most appropriate approach will depend on the information that is available and that which is desired. To understand how the well will respond to changing nonpoint-source contaminant inputs at the water table, some representation of the distribution of groundwater ages in the well is needed. Such information for production wells is sparse and difficult to obtain, especially in areas lacking detailed field studies. In this study, age distributions derived from detailed groundwater-flow models with advective particle tracking were compared with those generated from lumped-parameter models to examine conditions in which estimates from simpler, less resource-intensive lumped-parameter models could be used in place of estimates from particle-tracking models. In each of four contrasting hydrogeologic settings in the USA, particle-tracking and lumped-parameter models yielded roughly similar age distributions and largely indistinguishable contaminant trends when based on similar conceptual models and calibrated to similar tracer data. Although model calibrations and predictions were variably affected by tracer limitations and conceptual ambiguities, results illustrated the importance of full age distributions, rather than apparent tracer ages or model mean ages, for trend analysis and forecasting.

Online Multi-Modal Robust Non-Negative Dictionary Learning for Visual Tracking

PubMed Central

Zhang, Xiang; Guan, Naiyang; Tao, Dacheng; Qiu, Xiaogang; Luo, Zhigang

2015-01-01

Dictionary learning is a method of acquiring a collection of atoms for subsequent signal representation. Due to its excellent representation ability, dictionary learning has been widely applied in multimedia and computer vision. However, conventional dictionary learning algorithms fail to deal with multi-modal datasets. In this paper, we propose an online multi-modal robust non-negative dictionary learning (OMRNDL) algorithm to overcome this deficiency. Notably, OMRNDL casts visual tracking as a dictionary learning problem under the particle filter framework and captures the intrinsic knowledge about the target from multiple visual modalities, e.g., pixel intensity and texture information. To this end, OMRNDL adaptively learns an individual dictionary, i.e., template, for each modality from available frames, and then represents new particles over all the learned dictionaries by minimizing the fitting loss of data based on M-estimation. The resultant representation coefficient can be viewed as the common semantic representation of particles across multiple modalities, and can be utilized to track the target. OMRNDL incrementally learns the dictionary and the coefficient of each particle by using multiplicative update rules to respectively guarantee their non-negativity constraints. Experimental results on a popular challenging video benchmark validate the effectiveness of OMRNDL for visual tracking in both quantity and quality. PMID:25961715

Online multi-modal robust non-negative dictionary learning for visual tracking.

PubMed

Zhang, Xiang; Guan, Naiyang; Tao, Dacheng; Qiu, Xiaogang; Luo, Zhigang

2015-01-01

Dictionary learning is a method of acquiring a collection of atoms for subsequent signal representation. Due to its excellent representation ability, dictionary learning has been widely applied in multimedia and computer vision. However, conventional dictionary learning algorithms fail to deal with multi-modal datasets. In this paper, we propose an online multi-modal robust non-negative dictionary learning (OMRNDL) algorithm to overcome this deficiency. Notably, OMRNDL casts visual tracking as a dictionary learning problem under the particle filter framework and captures the intrinsic knowledge about the target from multiple visual modalities, e.g., pixel intensity and texture information. To this end, OMRNDL adaptively learns an individual dictionary, i.e., template, for each modality from available frames, and then represents new particles over all the learned dictionaries by minimizing the fitting loss of data based on M-estimation. The resultant representation coefficient can be viewed as the common semantic representation of particles across multiple modalities, and can be utilized to track the target. OMRNDL incrementally learns the dictionary and the coefficient of each particle by using multiplicative update rules to respectively guarantee their non-negativity constraints. Experimental results on a popular challenging video benchmark validate the effectiveness of OMRNDL for visual tracking in both quantity and quality.

Nuclear Track Detector Characterization via Alpha-Spectrometry for Radioprotection Use

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morelli, D.; Imme, G.; Catalano, R.

2011-12-13

Solid Nuclear Track Detectors (SNTDs), CR-39 type, are usually adopted to monitor radon gas concentrations. In order to characterize the detectors according to track geometrical parameters, detectors were irradiated inside a vacuum chamber by alpha particles at twelve energy values, obtained by different Mylar foils in front of a {sup 241}Am source. The alpha energy values were verified using a Si detector. After the exposure to the alpha particles, the detectors were chemically etched to enlarge the tracks, which were then analyzed by means of a semiautomatic system composed of an optical microscope equipped with a CCD camera connected tomore » a personal computer to store images. A suitable routine analyzed the track parameters: major and minor axis length and mean grey level, allowing us to differentiate tracks according to the incident alpha energy and then to individuate the discrimination factors for radon alpha tracks. The combined use of geometrical and optical parameters allows one to overcome the ambiguity in the alpha energy determination due to the non-monotonicity of each parameter versus energy. After track parameter determination, a calibration procedure was performed by means of a radon chamber. The calibration was verified through an inter-comparing survey.« less

Vapor etching of nuclear tracks in dielectric materials

DOEpatents

Musket, Ronald G.; Porter, John D.; Yoshiyama, James M.; Contolini, Robert J.

2000-01-01

A process involving vapor etching of nuclear tracks in dielectric materials for creating high aspect ratio (i.e., length much greater than diameter), isolated cylindrical holes in dielectric materials that have been exposed to high-energy atomic particles. The process includes cleaning the surface of the tracked material and exposing the cleaned surface to a vapor of a suitable etchant. Independent control of the temperatures of the vapor and the tracked materials provide the means to vary separately the etch rates for the latent track region and the non-tracked material. As a rule, the tracked regions etch at a greater rate than the non-tracked regions. In addition, the vapor-etched holes can be enlarged and smoothed by subsequent dipping in a liquid etchant. The 20-1000 nm diameter holes resulting from the vapor etching process can be useful as molds for electroplating nanometer-sized filaments, etching gate cavities for deposition of nano-cones, developing high-aspect ratio holes in trackable resists, and as filters for a variety of molecular-sized particles in virtually any liquid or gas by selecting the dielectric material that is compatible with the liquid or gas of interest.

Charge and energy spectra of particles with E from 0.2 to 30 MeV/nuc in the January 25, 1971 solar flare.

NASA Technical Reports Server (NTRS)

Price, P. B.; Sullivan, J. D.

1972-01-01

Tracks of 1000 solar particles with charge Z not less than 10 and tracks of about 150 particles with Z equal to 8 have been analyzed in a stack of plastic detectors exposed in a rocket during the solar flare of Jan. 25, 1971. The energy spectra peak at about 1.5 MeV/nuc, with the flux falling to zero at about 0.4 MeV/nuc. Fe, Si, and O appear to have similar energy spectra for energies between 2 and 12 MeV/nuc.

Lineage mapper: A versatile cell and particle tracker

NASA Astrophysics Data System (ADS)

Chalfoun, Joe; Majurski, Michael; Dima, Alden; Halter, Michael; Bhadriraju, Kiran; Brady, Mary

2016-11-01

The ability to accurately track cells and particles from images is critical to many biomedical problems. To address this, we developed Lineage Mapper, an open-source tracker for time-lapse images of biological cells, colonies, and particles. Lineage Mapper tracks objects independently of the segmentation method, detects mitosis in confluence, separates cell clumps mistakenly segmented as a single cell, provides accuracy and scalability even on terabyte-sized datasets, and creates division and/or fusion lineages. Lineage Mapper has been tested and validated on multiple biological and simulated problems. The software is available in ImageJ and Matlab at isg.nist.gov.

TrackArt: the user friendly interface for single molecule tracking data analysis and simulation applied to complex diffusion in mica supported lipid bilayers.

PubMed

Matysik, Artur; Kraut, Rachel S

2014-05-01

Single molecule tracking (SMT) analysis of fluorescently tagged lipid and protein probes is an attractive alternative to ensemble averaged methods such as fluorescence correlation spectroscopy (FCS) or fluorescence recovery after photobleaching (FRAP) for measuring diffusion in artificial and plasma membranes. The meaningful estimation of diffusion coefficients and their errors is however not straightforward, and is heavily dependent on sample type, acquisition method, and equipment used. Many approaches require advanced computing and programming skills for their implementation. Here we present TrackArt software, an accessible graphic interface for simulation and complex analysis of multiple particle paths. Imported trajectories can be filtered to eliminate spurious or corrupted tracks, and are then analyzed using several previously described methodologies, to yield single or multiple diffusion coefficients, their population fractions, and estimated errors. We use TrackArt to analyze the single-molecule diffusion behavior of a sphingolipid analog SM-Atto647N, in mica supported DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) bilayers. Fitting with a two-component diffusion model confirms the existence of two separate populations of diffusing particles in these bilayers on mica. As a demonstration of the TrackArt workflow, we characterize and discuss the effective activation energies required to increase the diffusion rates of these populations, obtained from Arrhenius plots of temperature-dependent diffusion. Finally, TrackArt provides a simulation module, allowing the user to generate models with multiple particle trajectories, diffusing with different characteristics. Maps of domains, acting as impermeable or permeable obstacles for particles diffusing with given rate constants and diffusion coefficients, can be simulated or imported from an image. Importantly, this allows one to use simulated data with a known diffusion behavior as a comparison for results acquired using particular algorithms on actual, "natural" samples whose diffusion behavior is to be extracted. It can also serve as a tool for demonstrating diffusion principles. TrackArt is an open source, platform-independent, Matlab-based graphical user interface, and is easy to use even for those unfamiliar with the Matlab programming environment. TrackArt can be used for accurate simulation and analysis of complex diffusion data, such as diffusion in lipid bilayers, providing publication-quality formatted results.

Time-reversibility and particle sedimentation

NASA Technical Reports Server (NTRS)

Golubitsky, Martin; Krupa, Martin; Lim, Chjan

1991-01-01

This paper studies an ODE model, called the Stokeslet model, and describes sedimentation of small clusters of particles in a highly viscous fluid. This model has a trivial solution in which the n particles arrange themselves at the vertices of a regular n-sided polygon. When n = 3, Hocking and Caflisch et al. (1988) proved the existence of periodic motion (in the frame moving with the center of gravity in the cluster) in which the particles form an isosceles triangle. Here, the study of periodic and quasi-periodic solutions of the Stokeslet model is continued, with emphasis on the spatial and time-reversal symmetry of the model. For three particles, the existence of a second family of periodic solutions and a family of quasi-periodic solutions is proved. It is also indicated how the methods generalize to the case of n particles.

Using Light Scattering to Track, Characterize and Manipulate Colloids

NASA Astrophysics Data System (ADS)

van Oostrum, P. D. J.

2011-03-01

A new technique is developed to analyze in-line Digital Holographic Microscopy images, making it possible to characterize, and track colloidal particles in three dimensions at unprecedented accuracy. We took digital snapshots of the interference pattern between the light scattered by micrometer particles and the unaltered portion of a laser beam that was used to illuminate dilute colloidal dispersions on a light microscope in transmission mode. We numerically fit Mie-theory for the light-scattering by micrometer sized particles to these experimental in-line holograms. The fit values give the position in three dimensions with an accuracy of a few nanometers in the lateral directions and several tens of nanometers in the axial direction. The individual particles radii and refractive indices could be determined to within tens of nanometers and a few hundredths respectively. By using a fast CCD camera, we can track particles with millisecond resolution in time which allows us to study dynamical properties such as the hydrodynamic radius and the sedimentation coefficient. The scattering behavior of the particles that we use to track and characterize colloidal particles makes it possible to exert pico-Newton forces on them close to a diffraction limited focus. When these effects are used to confine colloids in space, this technique is called Optical Tweezers. Both by numerical calculations and by experiments, we explore the possibilities of optical tweezers in soft condensed matter research. Using optical tweezers we placed multiple particles in interesting configurations to measure the interaction forces between them. The interaction forces were Yukawa-like screened charge repulsions. Careful timing of the blinking of time-shared optical tweezers and of the recording of holographic snapshots, we were able to measure interaction forces with femto-Newton accuracy from an analysis of (driven) Brownian motion. Forces exerted by external fields such as electric fields and gravity were measured as well. We induced electric dipoles in colloidal particles by applying radio frequency electric fields. Dipole induced strings of particles were formed and made permanent by van der Waals attractions or thermal annealing. Such colloidal strings form colloidal analogues of charged and un-charged (bio-) polymers. The diffusion and bending behavior of such strings was probed using DHM and optical tweezers.

Complete and Incomplete Hepatitis B Virus Particles: Formation, Function, and Application.

PubMed

Hu, Jianming; Liu, Kuancheng

2017-03-21

Hepatitis B virus (HBV) is a para-retrovirus or retroid virus that contains a double-stranded DNA genome and replicates this DNA via reverse transcription of a RNA pregenome. Viral reverse transcription takes place within a capsid upon packaging of the RNA and the viral reverse transcriptase. A major characteristic of HBV replication is the selection of capsids containing the double-stranded DNA, but not those containing the RNA or the single-stranded DNA replication intermediate, for envelopment during virion secretion. The complete HBV virion particles thus contain an outer envelope, studded with viral envelope proteins, that encloses the capsid, which, in turn, encapsidates the double-stranded DNA genome. Furthermore, HBV morphogenesis is characterized by the release of subviral particles that are several orders of magnitude more abundant than the complete virions. One class of subviral particles are the classical surface antigen particles (Australian antigen) that contain only the viral envelope proteins, whereas the more recently discovered genome-free (empty) virions contain both the envelope and capsid but no genome. In addition, recent evidence suggests that low levels of RNA-containing particles may be released, after all. We will summarize what is currently known about how the complete and incomplete HBV particles are assembled. We will discuss briefly the functions of the subviral particles, which remain largely unknown. Finally, we will explore the utility of the subviral particles, particularly, the potential of empty virions and putative RNA virions as diagnostic markers and the potential of empty virons as a vaccine candidate.

Kassiopeia: a modern, extensible C++ particle tracking package

NASA Astrophysics Data System (ADS)

Furse, Daniel; Groh, Stefan; Trost, Nikolaus; Babutzka, Martin; Barrett, John P.; Behrens, Jan; Buzinsky, Nicholas; Corona, Thomas; Enomoto, Sanshiro; Erhard, Moritz; Formaggio, Joseph A.; Glück, Ferenc; Harms, Fabian; Heizmann, Florian; Hilk, Daniel; Käfer, Wolfgang; Kleesiek, Marco; Leiber, Benjamin; Mertens, Susanne; Oblath, Noah S.; Renschler, Pascal; Schwarz, Johannes; Slocum, Penny L.; Wandkowsky, Nancy; Wierman, Kevin; Zacher, Michael

2017-05-01

The Kassiopeia particle tracking framework is an object-oriented software package using modern C++ techniques, written originally to meet the needs of the KATRIN collaboration. Kassiopeia features a new algorithmic paradigm for particle tracking simulations which targets experiments containing complex geometries and electromagnetic fields, with high priority put on calculation efficiency, customizability, extensibility, and ease-of-use for novice programmers. To solve Kassiopeia's target physics problem the software is capable of simulating particle trajectories governed by arbitrarily complex differential equations of motion, continuous physics processes that may in part be modeled as terms perturbing that equation of motion, stochastic processes that occur in flight such as bulk scattering and decay, and stochastic surface processes occurring at interfaces, including transmission and reflection effects. This entire set of computations takes place against the backdrop of a rich geometry package which serves a variety of roles, including initialization of electromagnetic field simulations and the support of state-dependent algorithm-swapping and behavioral changes as a particle’s state evolves. Thanks to the very general approach taken by Kassiopeia it can be used by other experiments facing similar challenges when calculating particle trajectories in electromagnetic fields. It is publicly available at https://github.com/KATRIN-Experiment/Kassiopeia.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lyn, Rodney K.; Department of Chemistry, University of Ottawa, Ottawa; Kennedy, David C.

Research highlights: {yields} Hepatitis C virus uses lipid droplets (LD) onto which HCV core proteins bind. {yields} HCV core proteins on LDs facilitate viral particle assembly. {yields} We used a novel combination of CARS, two-photon fluorescence, and DIC microscopies. {yields} Particle tracking experiments show that core slowly affects LD localization. {yields} Particle tracking measured the change in speed and directionality of LD movement. -- Abstract: The hepatitis C virus (HCV) is a global health problem, with limited treatment options and no vaccine available. HCV uses components of the host cell to proliferate, including lipid droplets (LD) onto which HCV coremore » proteins bind and facilitate viral particle assembly. We have measured the dynamics of HCV core protein-mediated changes in LDs and rates of LD movement on microtubules using a combination of coherent anti-Stokes Raman scattering (CARS), two-photon fluorescence (TPF), and differential interference contrast (DIC) microscopies. Results show that the HCV core protein induces rapid increases in LD size. Particle tracking experiments show that HCV core protein slowly affects LD localization by controlling the directionality of LD movement on microtubules. These dynamic processes ultimately aid HCV in propagating and the molecules and interactions involved represent novel targets for potential therapeutic intervention.« less

Interference from Proteins and Surfactants on Particle Size Distributions Measured by Nanoparticle Tracking Analysis (NTA).

PubMed

Bai, Kelvin; Barnett, Gregory V; Kar, Sambit R; Das, Tapan K

2017-04-01

Characterization of submicron protein particles continues to be challenging despite active developments in the field. NTA is a submicron particle enumeration technique, which optically tracks the light scattering signal from suspended particles undergoing Brownian motion. The submicron particle size range NTA can monitor in common protein formulations is not well established. We conducted a comprehensive investigation with several protein formulations along with corresponding placebos using NTA to determine submicron particle size distributions and shed light on potential non-particle origin of size distribution in the range of approximately 50-300 nm. NTA and DLS are performed on polystyrene size standards as well as protein and placebo formulations. Protein formulations filtered through a 20 nm filter, with and without polysorbate-80, show NTA particle counts. As such, particle counts above 20 nm are not expected in these solutions. Several other systems including positive and negative controls were studied using NTA and DLS. These apparent particles measured by NTA are not observed in DLS measurements and may not correspond to real particles. The intent of this article is to raise awareness about the need to interpret particle counts and size distribution from NTA with caution.

Multiple particle tracking in 3-D+t microscopy: method and application to the tracking of endocytosed quantum dots.

PubMed

Genovesio, Auguste; Liedl, Tim; Emiliani, Valentina; Parak, Wolfgang J; Coppey-Moisan, Maité; Olivo-Marin, Jean-Christophe

2006-05-01

We propose a method to detect and track multiple moving biological spot-like particles showing different kinds of dynamics in image sequences acquired through multidimensional fluorescence microscopy. It enables the extraction and analysis of information such as number, position, speed, movement, and diffusion phases of, e.g., endosomal particles. The method consists of several stages. After a detection stage performed by a three-dimensional (3-D) undecimated wavelet transform, we compute, for each detected spot, several predictions of its future state in the next frame. This is accomplished thanks to an interacting multiple model (IMM) algorithm which includes several models corresponding to different biologically realistic movement types. Tracks are constructed, thereafter, by a data association algorithm based on the maximization of the likelihood of each IMM. The last stage consists of updating the IMM filters in order to compute final estimations for the present image and to improve predictions for the next image. The performances of the method are validated on synthetic image data and used to characterize the 3-D movement of endocytic vesicles containing quantum dots.

Motion-compensated speckle tracking via particle filtering

NASA Astrophysics Data System (ADS)

Liu, Lixin; Yagi, Shin-ichi; Bian, Hongyu

2015-07-01

Recently, an improved motion compensation method that uses the sum of absolute differences (SAD) has been applied to frame persistence utilized in conventional ultrasonic imaging because of its high accuracy and relative simplicity in implementation. However, high time consumption is still a significant drawback of this space-domain method. To seek for a more accelerated motion compensation method and verify if it is possible to eliminate conventional traversal correlation, motion-compensated speckle tracking between two temporally adjacent B-mode frames based on particle filtering is discussed. The optimal initial density of particles, the least number of iterations, and the optimal transition radius of the second iteration are analyzed from simulation results for the sake of evaluating the proposed method quantitatively. The speckle tracking results obtained using the optimized parameters indicate that the proposed method is capable of tracking the micromotion of speckle throughout the region of interest (ROI) that is superposed with global motion. The computational cost of the proposed method is reduced by 25% compared with that of the previous algorithm and further improvement is necessary.

Simultaneous measurements of jellyfish bell kinematics and flow fields using PTV and PIV

NASA Astrophysics Data System (ADS)

Xu, Nicole; Dabiri, John

2016-11-01

A better understanding of jellyfish swimming can potentially improve the energy efficiency of aquatic vehicles or create biomimetic robots for ocean monitoring. Aurelia aurita is a simple oblate invertebrate composed of a flexible bell and coronal muscle, which contracts to eject water from the subumbrellar volume. Jellyfish locomotion can be studied by obtaining body kinematics or by examining the resulting fluid velocity fields using particle image velocimetry (PIV). Typically, swim kinematics are obtained by semi-manually tracking points of interest (POI) along the bell in video post-processing; simultaneous measurements of kinematics and flows involve using this semi-manual tracking method on PIV videos. However, we show that both the kinematics and flow fields can be directly visualized in 3D space by embedding phosphorescent particles in animals free-swimming in seeded environments. Particle tracking velocimetry (PTV) can then be used to calculate bell kinematics, such as pulse frequency, bell deformation, swim trajectories, and propulsive efficiency. By simultaneously tracking POI within the bell and collecting PIV data, we can further study the jellyfish's natural locomotive control mechanisms in conjunction with flow measurements. NSF GRFP.

Monte Carlo N-Particle Tracking of Ultrafine Particle Flow in Bent Micro-Tubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casella, Andrew M.; Loyalka, Sudarsham K.

2016-02-16

The problem of large pressure-differential driven laminar convective-diffusive ultrafine aerosol flow through bent micro-tubes is of interest in several contemporary research areas including; release of contents from pressurized containment vessels, aerosol sampling equipment, advanced scientific instruments, gas-phase micro-heat exchangers, and microfluidic devices. In each of these areas, the predominant problem is the determination of the fraction of particles entering the micro-tube that is deposited within the tube and the fraction that is transmitted through. Due to the extensive parameter restrictions of this class of problems, a Lagrangian particle tracking method making use of the coupling of the analytical stream linemore » solutions of Dean and the simplified Langevin equation is quite a useful tool in problem characterization. This method is a direct analog to the Monte Carlo N-Particle method of particle transport extensively used in nuclear physics and engineering. In this work, 10 nm diameter particles with a density of 1 g/cm3 are tracked within micro-tubes with toroidal bends with pressure differentials ranging between 0.2175 and 0.87 atmospheres. The tubes have radii of 25 microns and 50 microns and the radius of curvature is between 1 m and 0.3183 cm. The carrier gas is helium, and temperatures of 298 K and 558 K are considered. Numerical convergence is considered as a function of time step size and of the number of particles per simulation. Particle transmission rates and deposition patterns within the bent micro-tubes are calculated.« less

Efficient Green's Function Reaction Dynamics (GFRD) simulations for diffusion-limited, reversible reactions

NASA Astrophysics Data System (ADS)

Bashardanesh, Zahedeh; Lötstedt, Per

2018-03-01

In diffusion controlled reversible bimolecular reactions in three dimensions, a dissociation step is typically followed by multiple, rapid re-association steps slowing down the simulations of such systems. In order to improve the efficiency, we first derive an exact Green's function describing the rate at which an isolated pair of particles undergoing reversible bimolecular reactions and unimolecular decay separates beyond an arbitrarily chosen distance. Then the Green's function is used in an algorithm for particle-based stochastic reaction-diffusion simulations for prediction of the dynamics of biochemical networks. The accuracy and efficiency of the algorithm are evaluated using a reversible reaction and a push-pull chemical network. The computational work is independent of the rates of the re-associations.

The Simpsons program 6-D phase space tracking with acceleration

NASA Astrophysics Data System (ADS)

Machida, S.

1993-12-01

A particle tracking code, Simpsons, in 6-D phase space including energy ramping has been developed to model proton synchrotrons and storage rings. We take time as the independent variable to change machine parameters and diagnose beam quality in a quite similar way as real machines, unlike existing tracking codes for synchrotrons which advance a particle element by element. Arbitrary energy ramping and rf voltage curves as a function of time are read as an input file for defining a machine cycle. The code is used to study beam dynamics with time dependent parameters. Some of the examples from simulations of the Superconducting Super Collider (SSC) boosters are shown.

Three-Dimensional Stereoscopic Tracking Velocimetry and Experimental/Numerical Comparison of Directional Solidification

NASA Technical Reports Server (NTRS)

Lee, David; Ge, Yi; Cha, Soyoung Stephen; Ramachandran, Narayanan; Rose, M. Franklin (Technical Monitor)

2001-01-01

Measurement of three-dimensional (3-D) three-component velocity fields is of great importance in both ground and space experiments for understanding materials processing and fluid physics. The experiments in these fields most likely inhibit the application of conventional planar probes for observing 3-D phenomena. Here, we present the investigation results of stereoscopic tracking velocimetry (STV) for measuring 3-D velocity fields, which include diagnostic technology development, experimental velocity measurement, and comparison with analytical and numerical computation. STV is advantageous in system simplicity for building compact hardware and in software efficiency for continual near-real-time monitoring. It has great freedom in illuminating and observing volumetric fields from arbitrary directions. STV is based on stereoscopic observation of particles-Seeded in a flow by CCD sensors. In the approach, part of the individual particle images that provide data points is likely to be lost or cause errors when their images overlap and crisscross each other especially under a high particle density. In order to maximize the valid recovery of data points, neural networks are implemented for these two important processes. For the step of particle overlap decomposition, the back propagation neural network is utilized because of its ability in pattern recognition with pertinent particle image feature parameters. For the step of particle tracking, the Hopfield neural network is employed to find appropriate particle tracks based on global optimization. Our investigation indicates that the neural networks are very efficient and useful for stereoscopically tracking particles. As an initial assessment of the diagnostic technology performance, laminar water jets with and without pulsation are measured. The jet tip velocity profiles are in good agreement with analytical predictions. Finally, for testing in material processing applications, a simple directional solidification apparatus is built for experimenting with a metal analog of succinonitrile. Its 3-D velocity field at the liquid phase is then measured to be compared with those from numerical computation. Our theoretical, numerical, and experimental investigations have proven STV to be a viable candidate for reliably measuring 3-D flow velocities. With current activities are focused on further improving the processing efficiency, overall accuracy, and automation, the eventual efforts of broad experimental applications and concurrent numerical modeling validation will be vital to many areas in fluid flow and materials processing.

Object tracking with adaptive HOG detector and adaptive Rao-Blackwellised particle filter

NASA Astrophysics Data System (ADS)

Rosa, Stefano; Paleari, Marco; Ariano, Paolo; Bona, Basilio

2012-01-01

Scenarios for a manned mission to the Moon or Mars call for astronaut teams to be accompanied by semiautonomous robots. A prerequisite for human-robot interaction is the capability of successfully tracking humans and objects in the environment. In this paper we present a system for real-time visual object tracking in 2D images for mobile robotic systems. The proposed algorithm is able to specialize to individual objects and to adapt to substantial changes in illumination and object appearance during tracking. The algorithm is composed by two main blocks: a detector based on Histogram of Oriented Gradient (HOG) descriptors and linear Support Vector Machines (SVM), and a tracker which is implemented by an adaptive Rao-Blackwellised particle filter (RBPF). The SVM is re-trained online on new samples taken from previous predicted positions. We use the effective sample size to decide when the classifier needs to be re-trained. Position hypotheses for the tracked object are the result of a clustering procedure applied on the set of particles. The algorithm has been tested on challenging video sequences presenting strong changes in object appearance, illumination, and occlusion. Experimental tests show that the presented method is able to achieve near real-time performances with a precision of about 7 pixels on standard video sequences of dimensions 320 × 240.

Human tracking in thermal images using adaptive particle filters with online random forest learning

NASA Astrophysics Data System (ADS)

Ko, Byoung Chul; Kwak, Joon-Young; Nam, Jae-Yeal

2013-11-01

This paper presents a fast and robust human tracking method to use in a moving long-wave infrared thermal camera under poor illumination with the existence of shadows and cluttered backgrounds. To improve the human tracking performance while minimizing the computation time, this study proposes an online learning of classifiers based on particle filters and combination of a local intensity distribution (LID) with oriented center-symmetric local binary patterns (OCS-LBP). Specifically, we design a real-time random forest (RF), which is the ensemble of decision trees for confidence estimation, and confidences of the RF are converted into a likelihood function of the target state. First, the target model is selected by the user and particles are sampled. Then, RFs are generated using the positive and negative examples with LID and OCS-LBP features by online learning. The learned RF classifiers are used to detect the most likely target position in the subsequent frame in the next stage. Then, the RFs are learned again by means of fast retraining with the tracked object and background appearance in the new frame. The proposed algorithm is successfully applied to various thermal videos as tests and its tracking performance is better than those of other methods.

PARTICLE BEAM TRACKING CIRCUIT

DOEpatents

Anderson, O.A.

1959-05-01

>A particle-beam tracking and correcting circuit is described. Beam induction electrodes are placed on either side of the beam, and potentials induced by the beam are compared in a voltage comparator or discriminator. This comparison produces an error signal which modifies the fm curve at the voltage applied to the drift tube, thereby returning the orbit to the preferred position. The arrangement serves also to synchronize accelerating frequency and magnetic field growth. (T.R.H.)

Application of a novel new multispectral nanoparticle tracking technique

NASA Astrophysics Data System (ADS)

McElfresh, Cameron; Harrington, Tyler; Vecchio, Kenneth S.

2018-06-01

Fast, reliable, and accurate particle size analysis techniques must meet the demands of evolving industrial and academic research in areas of functionalized nanoparticle synthesis, advanced materials development, and other nanoscale enabled technologies. In this study a new multispectral particle tracking analysis (m-PTA) technique enabled by the ViewSizer™ 3000 (MANTA Instruments, USA) was evaluated using solutions of monomodal and multimodal gold and polystyrene latex nanoparticles, as well as a spark eroded polydisperse 316L stainless steel nanopowder, and large (non-Brownian) borosilicate particles. It was found that m-PTA performed comparably to the DLS in evaluation of monomodal particle size distributions. When measuring bimodal, trimodal and polydisperse solutions, the m-PTA technique overwhelmingly outperformed traditional dynamic light scattering (DLS) in both peak detection and relative particle concentration analysis. It was also observed that the m-PTA technique is less susceptible to large particle overexpression errors. The ViewSizer™ 3000 was also found to be successful in accurately evaluating sizes and concentrations of monomodal and bimodal sinking borosilicate particles.

Fluorescent image tracking velocimeter

DOEpatents

Shaffer, Franklin D.

1994-01-01

A multiple-exposure fluorescent image tracking velocimeter (FITV) detects and measures the motion (trajectory, direction and velocity) of small particles close to light scattering surfaces. The small particles may follow the motion of a carrier medium such as a liquid, gas or multi-phase mixture, allowing the motion of the carrier medium to be observed, measured and recorded. The main components of the FITV include: (1) fluorescent particles; (2) a pulsed fluorescent excitation laser source; (3) an imaging camera; and (4) an image analyzer. FITV uses fluorescing particles excited by visible laser light to enhance particle image detectability near light scattering surfaces. The excitation laser light is filtered out before reaching the imaging camera allowing the fluoresced wavelengths emitted by the particles to be detected and recorded by the camera. FITV employs multiple exposures of a single camera image by pulsing the excitation laser light for producing a series of images of each particle along its trajectory. The time-lapsed image may be used to determine trajectory and velocity and the exposures may be coded to derive directional information.

Positron emission particle tracking using a modular positron camera

NASA Astrophysics Data System (ADS)

Parker, D. J.; Leadbeater, T. W.; Fan, X.; Hausard, M. N.; Ingram, A.; Yang, Z.

2009-06-01

The technique of positron emission particle tracking (PEPT), developed at Birmingham in the early 1990s, enables a radioactively labelled tracer particle to be accurately tracked as it moves between the detectors of a "positron camera". In 1999 the original Birmingham positron camera, which consisted of a pair of MWPCs, was replaced by a system comprising two NaI(Tl) gamma camera heads operating in coincidence. This system has been successfully used for PEPT studies of a wide range of granular and fluid flow processes. More recently a modular positron camera has been developed using a number of the bismuth germanate (BGO) block detectors from standard PET scanners (CTI ECAT 930 and 950 series). This camera has flexible geometry, is transportable, and is capable of delivering high data rates. This paper presents simple models of its performance, and initial experience of its use in a range of geometries and applications.

Innovative molecular-based fluorescent nanoparticles for multicolor single particle tracking in cells

NASA Astrophysics Data System (ADS)

Daniel, Jonathan; Godin, Antoine G.; Palayret, Matthieu; Lounis, Brahim; Cognet, Laurent; Blanchard-Desce, Mireille

2016-03-01

Based on an original molecular-based design, we present bright and photostable fluorescent organic nanoparticles (FONs) showing excellent colloidal stability in various aqueous environments. Complementary near-infrared emitting and green emitting FONs were prepared using a simple, fast and robust protocol. Both types of FONs could be simultaneously imaged at the single-particle level in solution as well as in biological environments using a monochromatic excitation and a dual-color fluorescence microscope. No evidence of acute cytotoxicity was found upon incubation of live cells with mixed solutions of FONs, and both types of nanoparticles were found internalized in the cells where their motion could be simultaneously tracked at video-rate up to minutes. These fluorescent organic nanoparticles open a novel non-toxic alternative to existing nanoparticles for imaging biological structures, compatible with live-cell experiments and specially fitted for multicolor single particle tracking.

Effects of etching time on alpha tracks in solid state nuclear track detectors.

PubMed

Gillmore, Gavin; Wertheim, David; Crust, Simon

2017-01-01

Solid State Nuclear Track Detectors (SSNTDs) are used extensively for monitoring alpha particle radiation, neutron flux and cosmic ray radiation. Radon gas inhalation is regarded as being a significant contributory factor to lung cancer deaths in the UK each year. Gas concentrations are often monitored using CR39 based SSNTDs as the natural decay of radon results in alpha particles which form tracks in these detectors. Such tracks are normally etched for about 4h to enable microscopic analysis. This study examined the effect of etching time on the appearance of alpha tracks in SSNTDs by collecting 2D and 3D image datasets using laser confocal microscope imaging techniques. Etching times of 2 to 4h were compared and marked differences were noted in resultant track area. The median equivalent diameters of tracks were 20.2, 30.2 and 38.9μm for etching at 2, 3 and 4h respectively. Our results indicate that modern microscope imaging can detect and image the smaller size tracks seen for example at 3h etching time. Shorter etching times may give rise to fewer coalescing tracks although there is a balance to consider as smaller track sizes may be more difficult to image. Thus etching for periods of less than 4h clearly merits further investigation as this approach has the potential to improve accuracy in assessing the number of tracks. Copyright © 2016 Elsevier B.V. All rights reserved.

Study of nuclear multifragmentation induced by ultrarelativistic μ-mesons in nuclear track emulsion

NASA Astrophysics Data System (ADS)

Artemenkov, D. A.; Bradnova, V.; Firu, E.; Kornegrutsa, N. K.; Haiduc, M.; Mamatkulov, K. Z.; Kattabekov, R. R.; Neagu, A.; Rukoyatkin, P. A.; Rusakova, V. V.; Stanoeva, R.; Zaitsev, A. A.; Zarubin, P. I.; Zarubina, I. G.

2016-02-01

Exposures of test samples of nuclear track emulsion were analyzed. The formation of high-multiplicity nuclear stars was observed upon irradiating nuclear track emulsions with ultrarelativistic muons. Kinematical features studied in this exposure of nuclear track emulsions for events of the muon-induced splitting of carbon nuclei to three α-particles are indicative of the nuclear-diffraction interaction mechanism.

A New Method for Tracking Individual Particles During Bed Load Transport in a Gravel-Bed River

NASA Astrophysics Data System (ADS)

Tremblay, M.; Marquis, G. A.; Roy, A. G.; Chaire de Recherche Du Canada En Dynamique Fluviale

2010-12-01

Many particle tracers (passive or active) have been developed to study gravel movement in rivers. It remains difficult, however, to document resting and moving periods and to know how particles travel from one deposition site to another. Our new tracking method uses the Hobo Pendant G acceleration Data Logger to quantitatively describe the motion of individual particles from the initiation of movement, through the displacement and to the rest, in a natural gravel river. The Hobo measures the acceleration in three dimensions at a chosen temporal frequency. The Hobo was inserted into 11 artificial rocks. The rocks were seeded in Ruisseau Béard, a small gravel-bed river in the Yamaska drainage basin (Québec) where the hydraulics, particle sizes and bed characteristics are well known. The signals recorded during eight floods (Summer and Fall 2008-2009) allowed us to develop an algorithm which classifies the periods of rest and motion. We can differentiate two types of motion: sliding and rolling. The particles can also vibrate while remaining in the same position. The examination of the movement and vibration periods with respect to the hydraulic conditions (discharge, shear stress, stream power) showed that vibration occurred mostly before the rise of hydrograph and allowed us to establish movement threshold and response times. In all cases, particle movements occurred during floods but not always in direct response to increased bed shear stress and stream power. This method offers great potential to track individual particles and to establish a spatiotemporal sequence of the intermittent transport of the particle during a flood and to test theories concerning the resting periods of particles on a gravel bed.

Two moment dust and water ice in the MarsWRF GCM

NASA Astrophysics Data System (ADS)

Lee, Christopher; Richardson, Mark I.; Newman, Claire E.; Mischna, Michael A.

2016-10-01

A new two moment dust and water ice microphysics scheme has been developed for the MarsWRF General Circulation Model based on the Morrison and Gettelman (2008) scheme, and includes temperature dependent nucleation processes and energetically constrained condensation and evaporation. Dust consumed in the formation of water ice is also tracked by the model.The two moment dust scheme simulates dust particles in the Martian atmosphere using a Gamma distribution with fixed radius for lifted particles. Within the atmosphere the particle distribution is advected and sedimented within the two moment framework, obviating the requirement for lossy conversion between the continuous Gamma distribution and discritized bins found in some Mars microphysics schemes. Water ice is simulated using the same Gamma distribution and advected and sedimented in the same way. Water ice nucleation occurs heterogeneously onto dust particles with temperature dependent contact parameters (e.g. Trainer et al., 2009) and condensation and evaporation follows energetic constraints (e.g. Pruppacher and Klett, 1980; Montmessin et al., 2002) allowing water ice particles to grow in size where necessary. Dust particles are tracked within the ice cores as nucleation occurs, and dust cores advect and sediment along with their parent ice particle distributions. Radiative properties of dust and water particles are calculated as a function of the effective radius of the particles and the distribution width. The new microphysics scheme requires 5 tracers to be tracked as the moments of the dust, water ice, and ice core. All microphysical processes are simulated entirely within the two moment framework without any discretization of particle sizes.The effect of this new microphysics scheme on dust and water ice cloud distribution will be discussed and compared with observations from TES and MCS.

The preparation of uranium-adsorbed silica particles as a reference material for the fission track analysis

NASA Astrophysics Data System (ADS)

Park, Y. J.; Lee, M. H.; Pyo, H. Y.; Kim, H. A.; Sohn, S. C.; Jee, K. Y.; Kim, W. H.

2005-06-01

Uranium-adsorbed silica particles were prepared as a reference material for the fission track analysis (FTA) of swipe samples. A modified instrumental setup for particle generation, based on a commercial vibrating orifice aerosol generator to produce various sizes of droplets from a SiO 2 solution, is described. The droplets were transferred into a weak acidic solution bath to produce spherical solid silica particles. The classification of the silica particles in the range from 5 to 20 μm was carried out by the gravitational sedimentation method. The size distribution and morphology of the classified silica particles were investigated by scanning electron microscopy. The physicochemical properties of the classified silica particles such as the surface area, pore size and pore volume were measured. After an adsorption of 5% 235U on the silica particles in a solution adjusted to pH 4.5, the uranium-adsorbed silica particles were calcined up to 950 °C in a furnace to fix the uranium strongly onto the silica particles. The various sizes of uranium-adsorbed silica particles were applied to the FTA for use as a reference material.

Experimental investigation of clogging dynamics in homogeneous porous medium

NASA Astrophysics Data System (ADS)

Shen, Jikang; Ni, Rui

2017-03-01

A 3-D refractive-index matching Lagrangian particle tracking (3D-RIM-LPT) system was developed to study the filtration and the clogging process inside a homogeneous porous medium. A small subset of particles flowing through the porous medium was dyed and tracked. As this subset was randomly chosen, its dynamics is representative of all the rest. The statistics of particle locations, number, and velocity were obtained as functions of different volumetric concentrations. It is found that in our system the clogging time decays with the particle concentration following a power law relationship. As the concentration increases, there is a transition from depth filtration to cake filtration. At high concentration, more clogged pores lead to frequent flow redirections and more transverse migrations of particles. In addition, the velocity distribution in the transverse direction is symmetrical around zero, and it is slightly more intermittent than the random Gaussian curve due to particle-particle and particle-grain interactions. In contrast, as clogging develops, the longitudinal velocity of particles along the mean flow direction peaks near zero because of many trapped particles. But at the same time, the remaining open pores will experience larger pressure and, as a result, particles through those pores tend to have larger longitudinal velocities.

Reversal Reversed? The New Consensus on Education and Training

ERIC Educational Resources Information Center

Ainley, Patrick

2015-01-01

England for the foreseeable future is stuck with a one-track government that knows only the crisis measures with which Margaret Thatcher responded to the 1970s crisis of capital accumulation. Deregulation of all public services with privatization of provision on the contracting-out state model is seen as the solution to every problem and is a part…

Patton's tracks in the Mojave Desert, USA: An ecological legacy

USGS Publications Warehouse

Belnap, Jayne; Warren, Steven D.

2002-01-01

Recovery of soil properties from World War II-era military training exercises in the Mojave Desert was measured approximately 55 years following disturbance. Tracks from military vehicles were still visible, particularly in areas of desert pavement. Soil penetrability was much lower in visible tracks than outside the tracks. Soils in tracks had fewer rocks in the top 10cm of the soil profile than adjacent untracked soils. Larger particles (> 4.8mm) formed a moderately well-developed pavement outside of the tracks, while smaller, loose particles ( h 4.8mm) dominated the surface of the tracks. The time required to restore the desert pavement is likely to be measured in centuries. Based on biomass estimates, the cyanobacterial component of biological soil crusts had recovered 46-65% in tracks, compared to outside the tracks. Overall recovery of lichen cover has been much slower. Under plant canopies, cover of Collema tenax was not significantly different between areas inside and outside the tracks; however, recovery of Catapyrenium squamulosum was only 36%. In plant interspaces with less favorable moisture and temperature conditions, C. tenax showed a 6% recovery and C. squamulosum a 3% recovery. Assuming recovery of the biological soil crust is linear, and complete only when the most sensitive species (C. squamulosum) has fully recovered in the most limiting microhabitats (plant interspaces), it may require almost two millennia for full recovery of these areas.

Particle tracking velocimetry using echocardiographic data resolves flow in the left ventricle

NASA Astrophysics Data System (ADS)

Sampath, Kaushik; Abd, Thura T.; George, Richard T.; Katz, Joseph

2015-11-01

Two dimensional contrast echocardiography was performed on patients with a history of left ventricular (LV) thrombus. The 636 x 434 pixels electrocardiograms were recorded using a GE Vivid 9E system with (M5S-D and 4V-D) probes in a 2-D mode at a magnification of 0.3 mm/pix. The concentration of 2-4.5 micron seed bubbles was adjusted to obtain individually discernable traces, and a data acquisition rate of 60-90 fps kept the inter-frame displacements suitable for matching traces, and calculating vectors, but yet low enough to allow a scanning depth and width of upto 13 cm and 60 degrees respectively. Particle tracking velocimetry (PTV) guided by initial particle image velocimetry (PIV) was used to obtain the velocity distributions inside the LV with vector spacing of 3-5 mm. The data quality was greatly enhanced by implementing an iterative particle specific enhancement and tracking algorithm. Data covering 20 heart beats facilitated phase averaging. The results elucidated blood flow in the intra-ventricular septal region, lateral wall region, the apex of the LV and the mitral valve region.

Lunar sample contracts

NASA Technical Reports Server (NTRS)

Walker, R. M.

1974-01-01

The major scientific accomplishments through 1971 are reported for the particle track studies of lunar samples. Results are discussed of nuclear track measurements by optical and electron microscopy, thermoluminescence, X-ray diffraction, and differential thermal analysis.

Particle Filter Based Tracking in a Detection Sparse Discrete Event Simulation Environment

DTIC Science & Technology

2007-03-01

obtained by disqualifying a large number of particles. 52 (a) (b) ( c ) Figure 31. Particle Disqualification via Sanitization b...1 B. RESEARCH APPROACH..............................................................................5 C . THESIS ORGANIZATION...38 b. Detection Distribution Sampling............................................43 c . Estimated Position Calculation

The Lévy noise-induced current reversal phenomenon for self-propelled particles in a two-dimensional potential

NASA Astrophysics Data System (ADS)

Wang, Bing; Qu, Zhongwei; Li, Xuechao; Ma, Jianli

2017-08-01

Effects of Lévy noise on self-propelled particles in a two-dimensional potential is investigated. The current reversal phenomenon appears in the system. V (x-direction average velocity) changes from negative to positive with increasing asymmetry parameter β, and changes from positive to negative with increasing self-propelled velocity v0. V has a maximum with increasing modulation constant λ.

Aggregation and charging of sulfate and amidine latex particles in the presence of oxyanions.

PubMed

Sugimoto, Takuya; Cao, Tianchi; Szilagyi, Istvan; Borkovec, Michal; Trefalt, Gregor

2018-08-15

Electrophoretic mobility and time resolved light scattering are used to measure the effect on charging and aggregation of amidine and sulfate latex particles of different oxyanions namely, phosphate, arsenate, sulfate, and selenate. In the case of negatively charged sulfate latex particles oxyanions represent the coions, while they represent counterions in the case of the positively charged amidine latex. Repulsive interaction between the sulfate latex surface and the coions results in weak ion specific effects on the charging and aggregation. On the other hand the interaction of oxyanions with the amidine latex surface is highly specific. The monovalent dihydrogen phosphate ion strongly adsorbs to the positively charged surface and reverses the charge of the particle. This charge reversal leads also to the restabilization of the amidine latex suspension at the intermediate phosphate concentrations. In the case of dihydrogen arsenate the adsorption to amidine latex surface is weaker and no charge reversal and restabilization occurs. Similar differences are seen between the sulfate and selenate analogues, where selenate adsorbs more strongly to the surface as compared to the sulfate ion and invokes charge reversal. The present results indicate that ion specificity is much more pronounced in the case of counterions. Copyright © 2018 Elsevier Inc. All rights reserved.

Statistical Physics Experiments Using Dusty Plasmas

NASA Astrophysics Data System (ADS)

Goree, John

2016-10-01

Compared to other areas of physics research, Statistical Physics is heavily dominated by theory, with comparatively little experiment. One reason for the lack of experiments is the impracticality of tracking of individual atoms and molecules within a substance. Thus, there is a need for a different kind of experimental system, one where individual particles not only move stochastically as they collide with one another, but also are large enough to allow tracking. A dusty plasma can meet this need. A dusty plasma is a partially ionized gas containing small particles of solid matter. These micron-size particles gain thousands of electronic charges by collecting more electrons than ions. Their motions are dominated by Coulomb collisions with neighboring particles. In this so-called strongly coupled plasma, the dust particles self-organize in much the same way as atoms in a liquid or solid. Unlike atoms, however, these particles are large and slow, so that they can be tracked easily by video microscopy. Advantages of dusty plasma for experimental statistical physics research include particle tracking, lack of frictional contact with solid surfaces, and avoidance of overdamped motion. Moreover, the motion of a collection of dust particles can mimic an equilibrium system with a Maxwellian velocity distribution, even though the dust particles themselves are not truly in thermal equilibrium. Nonequilibrium statistical physics can be studied by applying gradients, for example by imposing a shear flow. In this talk I will review some of our recent experiments with shear flow. First, we performed the first experimental test to verify the Fluctuation Theorem for a shear flow, showing that brief violations of the Second Law of Thermodynamics occur with the predicted probabilities, for a small system. Second, we discovered a skewness of a shear-stress distribution in a shear flow. This skewness is a phenomenon that likely has wide applicability in nonequilibrium steady states. Third, we performed the first experimental test of a statistical physics theory (the Green-Kubo model) that is widely used by physical chemists to compute viscosity coefficients, and we found that it fails. Work supported by the U.S. Department of Energy, NSF, and NASA.

The artificial retina for track reconstruction at the LHC crossing rate

NASA Astrophysics Data System (ADS)

Abba, A.; Bedeschi, F.; Citterio, M.; Caponio, F.; Cusimano, A.; Geraci, A.; Marino, P.; Morello, M. J.; Neri, N.; Punzi, G.; Piucci, A.; Ristori, L.; Spinella, F.; Stracka, S.; Tonelli, D.

2016-04-01

We present the results of an R&D study for a specialized processor capable of precisely reconstructing events with hundreds of charged-particle tracks in pixel and silicon strip detectors at 40 MHz, thus suitable for processing LHC events at the full crossing frequency. For this purpose we design and test a massively parallel pattern-recognition algorithm, inspired to the current understanding of the mechanisms adopted by the primary visual cortex of mammals in the early stages of visual-information processing. The detailed geometry and charged-particle's activity of a large tracking detector are simulated and used to assess the performance of the artificial retina algorithm. We find that high-quality tracking in large detectors is possible with sub-microsecond latencies when the algorithm is implemented in modern, high-speed, high-bandwidth FPGA devices.

Parallelized Kalman-Filter-Based Reconstruction of Particle Tracks on Many-Core Processors and GPUs

NASA Astrophysics Data System (ADS)

Cerati, Giuseppe; Elmer, Peter; Krutelyov, Slava; Lantz, Steven; Lefebvre, Matthieu; Masciovecchio, Mario; McDermott, Kevin; Riley, Daniel; Tadel, Matevž; Wittich, Peter; Würthwein, Frank; Yagil, Avi

2017-08-01

For over a decade now, physical and energy constraints have limited clock speed improvements in commodity microprocessors. Instead, chipmakers have been pushed into producing lower-power, multi-core processors such as Graphical Processing Units (GPU), ARM CPUs, and Intel MICs. Broad-based efforts from manufacturers and developers have been devoted to making these processors user-friendly enough to perform general computations. However, extracting performance from a larger number of cores, as well as specialized vector or SIMD units, requires special care in algorithm design and code optimization. One of the most computationally challenging problems in high-energy particle experiments is finding and fitting the charged-particle tracks during event reconstruction. This is expected to become by far the dominant problem at the High-Luminosity Large Hadron Collider (HL-LHC), for example. Today the most common track finding methods are those based on the Kalman filter. Experience with Kalman techniques on real tracking detector systems has shown that they are robust and provide high physics performance. This is why they are currently in use at the LHC, both in the trigger and offine. Previously we reported on the significant parallel speedups that resulted from our investigations to adapt Kalman filters to track fitting and track building on Intel Xeon and Xeon Phi. Here, we discuss our progresses toward the understanding of these processors and the new developments to port the Kalman filter to NVIDIA GPUs.

Redistribution of ice nuclei between cloud and rain droplets: Parameterization and application to deep convective clouds

NASA Astrophysics Data System (ADS)

Paukert, M.; Hoose, C.; Simmel, M.

2017-03-01

In model studies of aerosol-dependent immersion freezing in clouds, a common assumption is that each ice nucleating aerosol particle corresponds to exactly one cloud droplet. In contrast, the immersion freezing of larger drops—"rain"—is usually represented by a liquid volume-dependent approach, making the parameterizations of rain freezing independent of specific aerosol types and concentrations. This may lead to inconsistencies when aerosol effects on clouds and precipitation shall be investigated, since raindrops consist of the cloud droplets—and corresponding aerosol particles—that have been involved in drop-drop-collisions. Here we introduce an extension to a two-moment microphysical scheme in order to account explicitly for particle accumulation in raindrops by tracking the rates of selfcollection, autoconversion, and accretion. This provides a direct link between ice nuclei and the primary formation of large precipitating ice particles. A new parameterization scheme of drop freezing is presented to consider multiple ice nuclei within one drop and effective drop cooling rates. In our test cases of deep convective clouds, we find that at altitudes which are most relevant for immersion freezing, the majority of potential ice nuclei have been converted from cloud droplets into raindrops. Compared to the standard treatment of freezing in our model, the less efficient mineral dust-based freezing results in higher rainwater contents in the convective core, affecting both rain and hail precipitation. The aerosol-dependent treatment of rain freezing can reverse the signs of simulated precipitation sensitivities to ice nuclei perturbations.

John F. Kennedy Space Center's Technology Development and Application 2006-2007 Report

NASA Technical Reports Server (NTRS)

2008-01-01

Topics covered include: Reversible Chemochromic Hydrogen Detectors; Determining Trajectory of Triboelectrically Charged Particles, Using Discrete Element Modeling; Using Indium Tin Oxide To Mitigate Dust on Viewing Ports; High-Performance Polyimide Powder Coatings; Controlled-Release Microcapsules for Smart Coatings for Corrosion Applications; Aerocoat 7 Replacement Coatings; Photocatalytic Coatings for Exploration and Spaceport Design; New Materials for the Repair of Polyimide Electrical Wire Insulation; Commodity-Free Calibration; Novel Ice Mitigation Methods; Crack Offset Measurement With the Projected Laser Target Device; New Materials for Structural Composites and Protective Coatings; Fire Chemistry Testing of Spray-On Foam Insulation (SOFI); Using Aerogel-Based Insulation Material To Prevent Foam Loss on the Liquid-Hydrogen Intertank; Particle Ejection and Levitation Technology (PELT); Electrostatic Characterization of Lunar Dust; Numerical Analysis of Rocket Exhaust Cratering; RESOLVE Projects: Lunar Water Resource Demonstration and Regolith Volatile Characterization; Tribocharging Lunar Soil for Electrostatic Beneficiation; Numerically Modeling the Erosion of Lunar Soil by Rocket Exhaust Plumes; Trajectory Model of Lunar Dust Particles; Using Lunar Module Shadows To Scale the Effects of Rocket Exhaust Plumes; Predicting the Acoustic Environment Induced by the Launch of the Ares I Vehicle; Measuring Ultrasonic Acoustic Velocity in a Thin Sheet of Graphite Epoxy Composite; Hail Size Distribution Mapping; Launch Pad 39 Hail Monitor Array System; Autonomous Flight Safety System - Phase III; The Photogrammetry Cube; Bird Vision System; Automating Range Surveillance Through Radio Interferometry and Field Strength Mapping Techniques; Next-Generation Telemetry Workstation; GPS Metric Tracking Unit; and Space-Based Range.

Solar Polar Imager: Observing Coronal Transients from a New Perspective (Invited)

NASA Astrophysics Data System (ADS)

Liewer, P. C.

2013-12-01

The heliophysics community has long recognized the need for a mission to observe the Sun and corona from a polar perspective. One mission concept, the Solar Polar Imager (SPI), has been studied extensively (Liewer et al in NASA Space Science Vision Missions, 2008). In this concept, a solar sail is used to place a spacecraft in a circular 0.48-AU heliocentric orbit with an inclination of ~75 degrees. This orbit enables crucial observations not possible from lower latitude perspectives. Magnetograph and Doppler observations from a polar vantage point would revolutionize our understanding of the mechanism of solar activity cycles, polar magnetic field reversals, the internal structure and dynamics of the Sun and its atmosphere. The rapid 4-month polar orbit combined with both in situ and remote sensing instrumentation further enables unprecedented studies of the physical connection between the Sun, the solar wind, and solar energetic particles. From the polar perspective, white light imagers could be used to track CMEs and predict their arrival at Earth (as demonstrated by STEREO). SPI is also well suited to study the relative roles of CME-driven shock versus flare-associated processes in solar energetic particle acceleration. With the circular 0.48 AU orbit, solar energetic particles could be more easily traced to their sources and their variation with latitude can be studied at a constant radius. This talk will discuss the science objectives, instrumentation and mission design for the SPI mission.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forest, E.; Hirata, Kohji

A methodological discussion is given for single particle beam dynamics in circular machines. The discussions are introductory, but (or, even therefore) we avoid to rely on too much simplified concepts. We treat things from a very general and fundamental point of view, because this is the easiest and rightest way to teach how to simulate particle motion and how to analyze its results. We give some principles of particle tracking free from theoretical prejudices. We also introduce some transparent methods to deduce the necessary information from the tracking: many of the traditional beam-dynamics concepts can be abstracted from them asmore » approximate quantities which are valid in certain limiting cases.« less

Real-time monitoring and visualization of the multi-dimensional motion of an anisotropic nanoparticle

NASA Astrophysics Data System (ADS)

Go, Gi-Hyun; Heo, Seungjin; Cho, Jong-Hoi; Yoo, Yang-Seok; Kim, Minkwan; Park, Chung-Hyun; Cho, Yong-Hoon

2017-03-01

As interest in anisotropic particles has increased in various research fields, methods of tracking such particles have become increasingly desirable. Here, we present a new and intuitive method to monitor the Brownian motion of a nanowire, which can construct and visualize multi-dimensional motion of a nanowire confined in an optical trap, using a dual particle tracking system. We measured the isolated angular fluctuations and translational motion of the nanowire in the optical trap, and determined its physical properties, such as stiffness and torque constants, depending on laser power and polarization direction. This has wide implications in nanoscience and nanotechnology with levitated anisotropic nanoparticles.

TRAX-CHEM: A pre-chemical and chemical stage extension of the particle track structure code TRAX in water targets

NASA Astrophysics Data System (ADS)

Boscolo, D.; Krämer, M.; Durante, M.; Fuss, M. C.; Scifoni, E.

2018-04-01

The production, diffusion, and interaction of particle beam induced water-derived radicals is studied with the a pre-chemical and chemical module of the Monte Carlo particle track structure code TRAX, based on a step by step approach. After a description of the model implemented, the chemical evolution of the most important products of water radiolysis is studied for electron, proton, helium, and carbon ion radiation at different energies. The validity of the model is verified by comparing the calculated time and LET dependent yield with experimental data from literature and other simulation approaches.

Objective comparison of particle tracking methods.

PubMed

Chenouard, Nicolas; Smal, Ihor; de Chaumont, Fabrice; Maška, Martin; Sbalzarini, Ivo F; Gong, Yuanhao; Cardinale, Janick; Carthel, Craig; Coraluppi, Stefano; Winter, Mark; Cohen, Andrew R; Godinez, William J; Rohr, Karl; Kalaidzidis, Yannis; Liang, Liang; Duncan, James; Shen, Hongying; Xu, Yingke; Magnusson, Klas E G; Jaldén, Joakim; Blau, Helen M; Paul-Gilloteaux, Perrine; Roudot, Philippe; Kervrann, Charles; Waharte, François; Tinevez, Jean-Yves; Shorte, Spencer L; Willemse, Joost; Celler, Katherine; van Wezel, Gilles P; Dan, Han-Wei; Tsai, Yuh-Show; Ortiz de Solórzano, Carlos; Olivo-Marin, Jean-Christophe; Meijering, Erik

2014-03-01

Particle tracking is of key importance for quantitative analysis of intracellular dynamic processes from time-lapse microscopy image data. Because manually detecting and following large numbers of individual particles is not feasible, automated computational methods have been developed for these tasks by many groups. Aiming to perform an objective comparison of methods, we gathered the community and organized an open competition in which participating teams applied their own methods independently to a commonly defined data set including diverse scenarios. Performance was assessed using commonly defined measures. Although no single method performed best across all scenarios, the results revealed clear differences between the various approaches, leading to notable practical conclusions for users and developers.

Robust and highly performant ring detection algorithm for 3d particle tracking using 2d microscope imaging

NASA Astrophysics Data System (ADS)

Afik, Eldad

2015-09-01

Three-dimensional particle tracking is an essential tool in studying dynamics under the microscope, namely, fluid dynamics in microfluidic devices, bacteria taxis, cellular trafficking. The 3d position can be determined using 2d imaging alone by measuring the diffraction rings generated by an out-of-focus fluorescent particle, imaged on a single camera. Here I present a ring detection algorithm exhibiting a high detection rate, which is robust to the challenges arising from ring occlusion, inclusions and overlaps, and allows resolving particles even when near to each other. It is capable of real time analysis thanks to its high performance and low memory footprint. The proposed algorithm, an offspring of the circle Hough transform, addresses the need to efficiently trace the trajectories of many particles concurrently, when their number in not necessarily fixed, by solving a classification problem, and overcomes the challenges of finding local maxima in the complex parameter space which results from ring clusters and noise. Several algorithmic concepts introduced here can be advantageous in other cases, particularly when dealing with noisy and sparse data. The implementation is based on open-source and cross-platform software packages only, making it easy to distribute and modify. It is implemented in a microfluidic experiment allowing real-time multi-particle tracking at 70 Hz, achieving a detection rate which exceeds 94% and only 1% false-detection.

A novel 3D micron-scale DPTV (Defocused Particle Tracking Velocimetry) and its applications in microfluidic devices

NASA Astrophysics Data System (ADS)

Roberts, John

2005-11-01

The rapid advancements in micro/nano biotechnology demand quantitative tools for characterizing microfluidic flows in lab-on-a-chip applications, validation of computational results for fully 3D flows in complex micro-devices, and efficient observation of cellular dynamics in 3D. We present a novel 3D micron-scale DPTV (defocused particle tracking velocimetry) that is capable of mapping out 3D Lagrangian, as well as 3D Eulerian velocity flow fields at sub-micron resolution and with one camera. The main part of the imaging system is an epi-fluorescent microscope (Olympus IX 51), and the seeding particles are fluorescent particles with diameter range 300nm - 10um. A software package has been developed for identifying (x,y,z,t) coordinates of the particles using the defocused images. Using the imaging system, we successfully mapped the pressure driven flow fields in microfluidic channels. In particular, we measured the Laglangian flow fields in a microfluidic channel with a herring bone pattern at the bottom, the later is used to enhance fluid mixing in lateral directions. The 3D particle tracks revealed the flow structure that has only been seen in numerical computation. This work is supported by the National Science Foundation (CTS - 0514443), the Nanobiotechnology Center at Cornell, and The New York State Center for Life Science Enterprise.

Heavy ion action on single cells: Cellular inactivation capability of single accelerated heavy ions

NASA Technical Reports Server (NTRS)

Kost, M.; Pross, H.-D.; Russmann, C.; Schneider, E.; Kiefer, J.; Kraft, G.; Lenz, G.; Becher, W.

1994-01-01

Heavy ions (HZE-particles) constitute an important part of radiation in space. Although their number is small the high amount of energy transferred by individual particles may cause severe biological effects. Their investigation requires special techniques which were tested by experiments performed at the UNILAC at the GSI (Darmstadt). Diploid yeast was used which is a suitable eucaryotic test system because of its resistance to extreme conditions like dryness and vacuum. Cells were placed on nuclear track detector foils and exposed to ions of different atomic number and energy. To assess the action of one single ion on an individual cell, track parameters and the respective colony forming abilities (CFA) were determined with the help of computer aided image analysis. There is mounting evidence that not only the amount of energy deposited along the particle path, commonly given by the LET, is of importance but also the spatial problem of energy deposition at a submicroscopical scale. It is virtually impossible to investigate track structure effects in detail with whole cell populations and (globally applied) high particle fluences. It is, therefore, necessary to detect the action of simple ions in individual cells. The results show that the biological action depends on atomic number and specific energy of the impinging ions, which can be compared with model calculations of recent track structure models.

Simulation study of pixel detector charge digitization

NASA Astrophysics Data System (ADS)

Wang, Fuyue; Nachman, Benjamin; Sciveres, Maurice; Lawrence Berkeley National Laboratory Team

2017-01-01

Reconstruction of tracks from nearly overlapping particles, called Tracking in Dense Environments (TIDE), is an increasingly important component of many physics analyses at the Large Hadron Collider as signatures involving highly boosted jets are investigated. TIDE makes use of the charge distribution inside a pixel cluster to resolve tracks that share one of more of their pixel detector hits. In practice, the pixel charge is discretized using the Time-over-Threshold (ToT) technique. More charge information is better for discrimination, but more challenging for designing and operating the detector. A model of the silicon pixels has been developed in order to study the impact of the precision of the digitized charge distribution on distinguishing multi-particle clusters. The output of the GEANT4-based simulation is used to train neutral networks that predict the multiplicity and location of particles depositing energy inside one cluster of pixels. By studying the multi-particle cluster identification efficiency and position resolution, we quantify the trade-off between the number of ToT bits and low-level tracking inputs. As both ATLAS and CMS are designing upgraded detectors, this work provides guidance for the pixel module designs to meet TIDE needs. Work funded by the China Scholarship Council and the Office of High Energy Physics of the U.S. Department of Energy under contract DE-AC02-05CH11231.

Apollo 15 contamination photography

NASA Technical Reports Server (NTRS)

Naumann, R. J.

1972-01-01

The problem of optical contamination in the form of particulates in the vicinity of a spacecraft has been a source of concern for any astronomical experiment that must be performed in sunlight. This concern prompted a photographic photometric experiment on Apollo 15 to measure the brightness of the residual contamination cloud as well as the cloud produced by dumping waste water overboard. An upper limit of 10 to the minus 12.3 power B (B designates the brightness of the solar disc) was placed on the residual cloud at a 90 deg sun angle, which is comparable to the zodiacal light. The brightness of the cloud produced by the waste dump was estimated to be 10 to the minus 9.2 power B. It was observed to decrease rapidly to 10 to the -11.6 power B in minutes, then fluctuate in brightness for at least 25 minutes as additional material left the spacecraft. The cloud was observed to consist of individually resolved particle tracks estimated to be particles ranging from millimeters to centimeters in diameter in addition to a background of unresolved particles with an average diameter of 10.5 microns. Most of the tracks proceeded in straight-line paths from the dump nozzle. Several tracks violated this direction, apparently having been scattered by collisions. A few tracks appeared to have definite curvatures, which are believed to be caused by charged particle interactions.

Modelling study of three-dimensional circulation and particle movement over the Sable Gully of Nova Scotia

NASA Astrophysics Data System (ADS)

Shan, Shiliang; Sheng, Jinyu; Greenan, Blair John William

2014-01-01

The Sable Gully is a broad deep underwater canyon located to the east of Sable Island on the edge of the Scotian Shelf. Being the home of many marine species including the endangered Northern Bottlenose Whale, the Gully was designated as a marine protected area (MPA) in 2004. Better understanding of physical environmental conditions over this MPA is needed for sustainable ecosystem management. In this study, a multi-nested ocean circulation model and a particle tracking model are used to examine the three-dimensional (3D) circulation and movement of particles carried passively by the flow over the Sable Gully. The 3D circulation model is driven by tides, wind, and surface heat/freshwater fluxes. The model performance is assessed by comparing the results with the previous numerical tidal results and current meter observations made in the Gully. The simulated tidal circulation over the Gully and adjacent waters is relatively strong on shallow banks and relatively weak on the continental slope. Below the depth of the Gully rim ( ˜ 200 m), the tidal currents are constrained by the thalweg of the Gully and amplified toward the Gully head. The simulated subtidal circulation in the Gully has a complex spatial structure and significant seasonal variability. The simulated time-dependent 3D flow fields are then used in a particle tracking model to study the particle movements, downstream and upstream areas, and residence time of the Gully. Based on the movements of particles released at the depth of the Gully rim and tracked forward in time, the e-folding residence time is estimated to be about 7 and 13 days in February and August 2006, respectively. The Gully flanks are identified as high retention areas with the typical residence time of 10 and 20 days in February and August 2006, respectively. Tracking particles with and without tides reveals that tidal circulation reduces the value of residence time in the Gully, particularly along the Gully flanks.

Quantitative organic vapor-particle sampler

DOEpatents

Gundel, Lara; Daisey, Joan M.; Stevens, Robert K.

1998-01-01

A quantitative organic vapor-particle sampler for sampling semi-volatile organic gases and particulate components. A semi-volatile organic reversible gas sorbent macroreticular resin agglomerates of randomly packed microspheres with the continuous porous structure of particles ranging in size between 0.05-10 .mu.m for use in an integrated diffusion vapor-particle sampler.

An artificial retina processor for track reconstruction at the LHC crossing rate

DOE PAGES

Bedeschi, F.; Cenci, R.; Marino, P.; ...

2017-11-23

The goal of the INFN-RETINA R&D project is to develop and implement a computational methodology that allows to reconstruct events with a large number (> 100) of charged-particle tracks in pixel and silicon strip detectors at 40 MHz, thus matching the requirements for processing LHC events at the full bunch-crossing frequency. Our approach relies on a parallel pattern-recognition algorithm, dubbed artificial retina, inspired by the early stages of image processing by the brain. In order to demonstrate that a track-processing system based on this algorithm is feasible, we built a sizable prototype of a tracking processor tuned to 3 000more » patterns, based on already existing readout boards equipped with Altera Stratix III FPGAs. The detailed geometry and charged-particle activity of a large tracking detector currently in operation are used to assess its performances. Here, we report on the test results with such a prototype.« less

Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination

NASA Astrophysics Data System (ADS)

Perillo, Evan P.; Liu, Yen-Liang; Huynh, Khang; Liu, Cong; Chou, Chao-Kai; Hung, Mien-Chie; Yeh, Hsin-Chih; Dunn, Andrew K.

2015-07-01

Molecular trafficking within cells, tissues and engineered three-dimensional multicellular models is critical to the understanding of the development and treatment of various diseases including cancer. However, current tracking methods are either confined to two dimensions or limited to an interrogation depth of ~15 μm. Here we present a three-dimensional tracking method capable of quantifying rapid molecular transport dynamics in highly scattering environments at depths up to 200 μm. The system has a response time of 1 ms with a temporal resolution down to 50 μs in high signal-to-noise conditions, and a spatial localization precision as good as 35 nm. Built on spatiotemporally multiplexed two-photon excitation, this approach requires only one detector for three-dimensional particle tracking and allows for two-photon, multicolour imaging. Here we demonstrate three-dimensional tracking of epidermal growth factor receptor complexes at a depth of ~100 μm in tumour spheroids.

A ridge tracking algorithm and error estimate for efficient computation of Lagrangian coherent structures.

PubMed

Lipinski, Doug; Mohseni, Kamran

2010-03-01

A ridge tracking algorithm for the computation and extraction of Lagrangian coherent structures (LCS) is developed. This algorithm takes advantage of the spatial coherence of LCS by tracking the ridges which form LCS to avoid unnecessary computations away from the ridges. We also make use of the temporal coherence of LCS by approximating the time dependent motion of the LCS with passive tracer particles. To justify this approximation, we provide an estimate of the difference between the motion of the LCS and that of tracer particles which begin on the LCS. In addition to the speedup in computational time, the ridge tracking algorithm uses less memory and results in smaller output files than the standard LCS algorithm. Finally, we apply our ridge tracking algorithm to two test cases, an analytically defined double gyre as well as the more complicated example of the numerical simulation of a swimming jellyfish. In our test cases, we find up to a 35 times speedup when compared with the standard LCS algorithm.

Accelerating CR-39 Track Detector Processing by Utilizing UV

NASA Astrophysics Data System (ADS)

Sparling, Jonathan; Padalino, Stephen; McLean, James; Sangster, Craig; Regan, Sean

2017-10-01

The use of CR-39 plastic as a Solid State Nuclear Track Detector is an effective technique for obtaining data in high energy particle experiments including inertial confinement fusion. To reveal particle tracks after irradiation, CR-39 is chemically etched in NaOH at 80°C, producing micron-scale signal pits at the nuclear track sites. It has been shown that illuminating CR-39 with UV light prior to etching increases bulk and track etch rates, especially when combined with elevated temperature. Spectroscopic analysis for amorphous solids has helped identify which UV wavelengths are most effective at enhancing etch rates. Absorption peaks found in the near infrared range provide for efficient sample heating, and may allow targeting cooperative IR-UV chemistry. Avoiding UV induced noise can be achieved through variations in absorption depths with wavelength. Vacuum drying and water absorption tests allow measurement of the resulting variation of bulk etch rate with depth. Funded in part by the NSF and an Department of Energy Grant through the Lab of Laser Energetics.

Study of performance of the ATLAS transition radiation tracker in run 1 of the LHC: Tracking characteristics

NASA Astrophysics Data System (ADS)

Belyaev, N.; Krasnopevtsev, D.; Smirnov, N.

2018-01-01

The ATLAS Transition Radiation Tracker (TRT) contains more than 350000 large straw tubes and it is the outermost of the three subsystems of the ATLAS Inner Detector (ID). The TRT contributes substantially to the ATLAS ID resolution for the tracks of high-energy particles, providing excellent particle identification capabilities and electron-pion separation. Basic performance parameters of the TRT related to its tracking function are described in this paper. The data used in this study were collected during the first period of the Large Hadron Collider (LHC) operation in 2012 with a proton collision energy of 8 TeV. The tracking performance of the TRT has been studied in the case of operating with a Xe-based gas mixture and as a function of the straw occupancy. Special attention was paid to investigation of tracking parameters inside hadronic jets. The experimental data and simulation are in reasonable agreement, even within the dense cores of the most energetic jets.

Implementation of the P barANDA Planar-GEM tracking detector in Monte Carlo simulations

NASA Astrophysics Data System (ADS)

Divani Veis, Nazila; Ehret, Andre; Firoozabadi, Mohammad M.; Karabowicz, Radoslaw; Maas, Frank; Saito, Nami; Saito, Takehiko R.; Voss, Bernd; PANDA Gem-Tracker Subgroup

2018-02-01

The P barANDA experiment at FAIR will be performed to investigate different aspects of hadron physics using anti-proton beams interacting with a fixed nuclear target. The experimental setup consists of a complex series of detector components covering a large solid angle. A detector with a gaseous active media equipped with gas electron multiplier (GEM) technique will be employed to measure tracks of charged particles at forward direction in order to achieve a high momentum resolution. In this work, a full setup of the GEM tracking detector has been implemented in the P barANDA Monte Carlo simulation package (PandaRoot) based on the current technical and conceptual design, and the expected performance of the P barANDA GEM-tracking detector has been investigated. Furthermore, material-budget studies in terms of the radiation length of the P barANDA GEM-tracking detector have been made in order to investigate the effect of the detector materials and its associated structures to particle measurements.

An artificial retina processor for track reconstruction at the LHC crossing rate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bedeschi, F.; Cenci, R.; Marino, P.

The goal of the INFN-RETINA R&D project is to develop and implement a computational methodology that allows to reconstruct events with a large number (> 100) of charged-particle tracks in pixel and silicon strip detectors at 40 MHz, thus matching the requirements for processing LHC events at the full bunch-crossing frequency. Our approach relies on a parallel pattern-recognition algorithm, dubbed artificial retina, inspired by the early stages of image processing by the brain. In order to demonstrate that a track-processing system based on this algorithm is feasible, we built a sizable prototype of a tracking processor tuned to 3 000more » patterns, based on already existing readout boards equipped with Altera Stratix III FPGAs. The detailed geometry and charged-particle activity of a large tracking detector currently in operation are used to assess its performances. Here, we report on the test results with such a prototype.« less

Discovery of nuclear tracks in interplanetary dust

NASA Technical Reports Server (NTRS)

Bradley, J. P.; Brownlee, D. E.; Fraundorf, P.

1984-01-01

Nuclear tracks have been identified in interplanetary dust particles (IDP's) collected from the stratosphere. The presence of tracks unambiguously confirms the extraterrestrial nature of IDP's, and the high track densities (10 to the 10th to 10 to the 11th per square centimeter) suggest an exposure age of approximately 10,000 years within the inner solar system. Tracks also provide an upper temperature limit for the heating of IDP's during atmospheric entry, thereby making it possible to distinguish between pristine and thermally modified micrometeorites.

Detectors (5/5)

ScienceCinema

None

2018-02-01

This lecture will serve as an introduction to particle detectors and detection techniques. In the first lecture, a historic overview of particle detector development will be given. In the second lecture, some basic techniques and concepts for particle detection will be discussed. In the third lecture, the interaction of particles with matter, the basis of particle detection, will be presented. The fourth and fifth lectures will discuss different detector types used for particle tracking, energy measurement and particle identification.

Detectors (4/5)

ScienceCinema

None

2018-05-14

This lecture will serve as an introduction to particle detectors and detection techniques. In the first lecture, a historic overview of particle detector development will be given. In the second lecture, some basic techniques and concepts for particle detection will be discussed. In the third lecture, the interaction of particles with matter, the basis of particle detection, will be presented. The fourth and fifth lectures will discuss different detector types used for particle tracking, energy measurement and particle identification.

The Retarding Force on a Fan-Cart Reversing Direction

ERIC Educational Resources Information Center

Aurora, Tarlok S.; Brunner, Bernard J.

2011-01-01

In introductory physics, students learn that an object tossed upward has a constant downward acceleration while going up, at the highest point and while falling down. To demonstrate this concept, a self-propelled fan cart system is used on a frictionless track. A quick push is given to the fan cart and it is allowed to move away on a track under…

Reversing Course in Pennsylvania Higher Education: The Two Tiers in Faculty Pay and Benefits and a Way Forward

ERIC Educational Resources Information Center

Brill, Deidre; Herzenberg, Stephen

2010-01-01

Over the last generation, the instructional staffing system in U.S. higher education has experienced a significant reduction in the proportion of jobs for full-time tenured and tenure-track faculty members and a dramatic growth in "contingent" instructors--full-time non tenure track, part-time/adjunct faculty and graduate employees.…

Track reconstruction in the emulsion-lead target of the OPERA experiment using the ESS microscope

NASA Astrophysics Data System (ADS)

Arrabito, L.; Bozza, C.; Buontempo, S.; Consiglio, L.; Cozzi, M.; D'Ambrosio, N.; DeLellis, G.; DeSerio, M.; Di Capua, F.; Di Ferdinando, D.; Di Marco, N.; Ereditato, A.; Esposito, L. S.; Fini, R. A.; Giacomelli, G.; Giorgini, M.; Grella, G.; Ieva, M.; Janicsko Csathy, J.; Juget, F.; Kreslo, I.; Laktineh, I.; Manai, K.; Mandrioli, G.; Marotta, A.; Migliozzi, P.; Monacelli, P.; Moser, U.; Muciaccia, M. T.; Pastore, A.; Patrizii, L.; Petukhov, Y.; Pistillo, C.; Pozzato, M.; Romano, G.; Rosa, G.; Russo, A.; Savvinov, N.; Schembri, A.; Scotto Lavina, L.; Simone, S.; Sioli, M.; Sirignano, C.; Sirri, G.; Strolin, P.; Tioukov, V.; Waelchli, T.

2007-05-01

The OPERA experiment, designed to conclusively prove the existence of νμ→ντ oscillations in the atmospheric sector, makes use of a massive lead-nuclear emulsion target to observe the appearance of ντ's in the CNGS νμ beam. The location and analysis of the neutrino interactions in quasi real-time required the development of fast computer-controlled microscopes able to reconstruct particle tracks with sub-micron precision and high efficiency at a speed of ~20 cm2/h. This paper describes the performance in particle track reconstruction of the European Scanning System, a novel automatic microscope for the measurement of emulsion films developed for OPERA.

Novel particle tracking algorithm based on the Random Sample Consensus Model for the Active Target Time Projection Chamber (AT-TPC)

NASA Astrophysics Data System (ADS)

Ayyad, Yassid; Mittig, Wolfgang; Bazin, Daniel; Beceiro-Novo, Saul; Cortesi, Marco

2018-02-01

The three-dimensional reconstruction of particle tracks in a time projection chamber is a challenging task that requires advanced classification and fitting algorithms. In this work, we have developed and implemented a novel algorithm based on the Random Sample Consensus Model (RANSAC). The RANSAC is used to classify tracks including pile-up, to remove uncorrelated noise hits, as well as to reconstruct the vertex of the reaction. The algorithm, developed within the Active Target Time Projection Chamber (AT-TPC) framework, was tested and validated by analyzing the 4He+4He reaction. Results, performance and quality of the proposed algorithm are presented and discussed in detail.

The electrobrachistochrone

NASA Astrophysics Data System (ADS)

Lipscombe, Trevor C.; Mungan, Carl E.

2018-05-01

The brachistochrone problem consists of finding the track of shortest travel time between given initial and final points for a particle sliding frictionlessly along it under the influence of a given external force field. Solvable variations of the standard example of a uniform gravitational field would be suitable for homework and computer projects by undergraduate physics students studying intermediate mechanics and electromagnetism. An electrobrachistochrone problem is here proposed, in which a charged particle moves along a frictionless track under the influence of its electrostatic force of attraction to an image charge in a grounded conducting plane below the track. The path of least time is found to be a foreshortened cycloid and its properties are investigated analytically and graphically.

Volume-weighted particle-tracking method for solute-transport modeling; Implementation in MODFLOW–GWT

USGS Publications Warehouse

Winston, Richard B.; Konikow, Leonard F.; Hornberger, George Z.

2018-02-16

In the traditional method of characteristics for groundwater solute-transport models, advective transport is represented by moving particles that track concentration. This approach can lead to global mass-balance problems because in models of aquifers having complex boundary conditions and heterogeneous properties, particles can originate in cells having different pore volumes and (or) be introduced (or removed) at cells representing fluid sources (or sinks) of varying strengths. Use of volume-weighted particles means that each particle tracks solute mass. In source or sink cells, the changes in particle weights will match the volume of water added or removed through external fluxes. This enables the new method to conserve mass in source or sink cells as well as globally. This approach also leads to potential efficiencies by allowing the number of particles per cell to vary spatially—using more particles where concentration gradients are high and fewer where gradients are low. The approach also eliminates the need for the model user to have to distinguish between “weak” and “strong” fluid source (or sink) cells. The new model determines whether solute mass added by fluid sources in a cell should be represented by (1) new particles having weights representing appropriate fractions of the volume of water added by the source, or (2) distributing the solute mass added over all particles already in the source cell. The first option is more appropriate for the condition of a strong source; the latter option is more appropriate for a weak source. At sinks, decisions whether or not to remove a particle are replaced by a reduction in particle weight in proportion to the volume of water removed. A number of test cases demonstrate that the new method works well and conserves mass. The method is incorporated into a new version of the U.S. Geological Survey’s MODFLOW–GWT solute-transport model.

Stereo imaging velocimetry for microgravity applications

NASA Technical Reports Server (NTRS)

Miller, Brian B.; Meyer, Maryjo B.; Bethea, Mark D.

1994-01-01

Stereo imaging velocimetry is the quantitative measurement of three-dimensional flow fields using two sensors recording data from different vantage points. The system described in this paper, under development at NASA Lewis Research Center in Cleveland, Ohio, uses two CCD cameras placed perpendicular to one another, laser disk recorders, an image processing substation, and a 586-based computer to record data at standard NTSC video rates (30 Hertz) and reduce it offline. The flow itself is marked with seed particles, hence the fluid must be transparent. The velocimeter tracks the motion of the particles, and from these we deduce a multipoint (500 or more), quantitative map of the flow. Conceptually, the software portion of the velocimeter can be divided into distinct modules. These modules are: camera calibration, particle finding (image segmentation) and centroid location, particle overlap decomposition, particle tracking, and stereo matching. We discuss our approach to each module, and give our currently achieved speed and accuracy for each where available.

High-precision tracking of brownian boomerang colloidal particles confined in quasi two dimensions.

PubMed

Chakrabarty, Ayan; Wang, Feng; Fan, Chun-Zhen; Sun, Kai; Wei, Qi-Huo

2013-11-26

In this article, we present a high-precision image-processing algorithm for tracking the translational and rotational Brownian motion of boomerang-shaped colloidal particles confined in quasi-two-dimensional geometry. By measuring mean square displacements of an immobilized particle, we demonstrate that the positional and angular precision of our imaging and image-processing system can achieve 13 nm and 0.004 rad, respectively. By analyzing computer-simulated images, we demonstrate that the positional and angular accuracies of our image-processing algorithm can achieve 32 nm and 0.006 rad. Because of zero correlations between the displacements in neighboring time intervals, trajectories of different videos of the same particle can be merged into a very long time trajectory, allowing for long-time averaging of different physical variables. We apply this image-processing algorithm to measure the diffusion coefficients of boomerang particles of three different apex angles and discuss the angle dependence of these diffusion coefficients.

Search for fractionally charged particles in pp collisions at s=7TeV

NASA Astrophysics Data System (ADS)

Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Aguilo, E.; Bergauer, T.; Dragicevic, M.; Erö, J.; Fabjan, C.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hammer, J.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Kiesenhofer, W.; Knünz, V.; Krammer, M.; Krätschmer, I.; Liko, D.; Mikulec, I.; Pernicka, M.; Rahbaran, B.; Rohringer, C.; Rohringer, H.; Schöfbeck, R.; Strauss, J.; Taurok, A.; Waltenberger, W.; Walzel, G.; Widl, E.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Bansal, M.; Bansal, S.; Cornelis, T.; De Wolf, E. A.; Janssen, X.; Luyckx, S.; Mucibello, L.; Ochesanu, S.; Roland, B.; Rougny, R.; Selvaggi, M.; Staykova, Z.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Blekman, F.; Blyweert, S.; D'Hondt, J.; Gonzalez Suarez, R.; Kalogeropoulos, A.; Maes, M.; Olbrechts, A.; Van Doninck, W.; Van Mulders, P.; Van Onsem, G. P.; Villella, I.; Clerbaux, B.; De Lentdecker, G.; Dero, V.; Gay, A. P. R.; Hreus, T.; Léonard, A.; Marage, P. E.; Mohammadi, A.; Reis, T.; Thomas, L.; Vander Marcken, G.; Vander Velde, C.; Vanlaer, P.; Wang, J.; Adler, V.; Beernaert, K.; Cimmino, A.; Costantini, S.; Garcia, G.; Grunewald, M.; Klein, B.; Lellouch, J.; Marinov, A.; Mccartin, J.; Ocampo Rios, A. A.; Ryckbosch, D.; Strobbe, N.; Thyssen, F.; Tytgat, M.; Verwilligen, P.; Walsh, S.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Bruno, G.; Castello, R.; Ceard, L.; Delaere, C.; du Pree, T.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Lemaitre, V.; Liao, J.; Militaru, O.; Nuttens, C.; Pagano, D.; Pin, A.; Piotrzkowski, K.; Schul, N.; Vizan Garcia, J. M.; Beliy, N.; Caebergs, T.; Daubie, E.; Hammad, G. H.; Alves, G. A.; Correa Martins Junior, M.; De Jesus Damiao, D.; Martins, T.; Pol, M. E.; Souza, M. H. G.; Aldá Júnior, W. L.; Carvalho, W.; Custódio, A.; Da Costa, E. M.; De Oliveira Martins, C.; Fonseca De Souza, S.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Oguri, V.; Prado Da Silva, W. L.; Santoro, A.; Soares Jorge, L.; Sznajder, A.; Anjos, T. S.; Bernardes, C. A.; Dias, F. A.; Tomei, T. R. Fernandez Perez; Gregores, E. M.; Lagana, C.; Marinho, F.; Mercadante, P. G.; Novaes, S. F.; Padula, Sandra S.; Genchev, V.; Iaydjiev, P.; Piperov, S.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Tcholakov, V.; Trayanov, R.; Vutova, M.; Dimitrov, A.; Hadjiiska, R.; Kozhuharov, V.; Litov, L.; Pavlov, B.; Petkov, P.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Jiang, C. H.; Liang, D.; Liang, S.; Meng, X.; Tao, J.; Wang, J.; Wang, X.; Wang, Z.; Xiao, H.; Xu, M.; Zang, J.; Zhang, Z.; Asawatangtrakuldee, C.; Ban, Y.; Guo, Y.; Li, W.; Liu, S.; Mao, Y.; Qian, S. J.; Teng, H.; Wang, D.; Zhang, L.; Zou, W.; Avila, C.; Gomez, J. P.; Gomez Moreno, B.; Osorio Oliveros, A. F.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Plestina, R.; Polic, D.; Puljak, I.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Duric, S.; Kadija, K.; Luetic, J.; Morovic, S.; Attikis, A.; Galanti, M.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Finger, M.; Finger, M., Jr.; Assran, Y.; Elgammal, S.; Ellithi Kamel, A.; Khalil, S.; Mahmoud, M. A.; Radi, A.; Kadastik, M.; Müntel, M.; Raidal, M.; Rebane, L.; Tiko, A.; Eerola, P.; Fedi, G.; Voutilainen, M.; Härkönen, J.; Heikkinen, A.; Karimäki, V.; Kinnunen, R.; Kortelainen, M. J.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Ungaro, D.; Wendland, L.; Banzuzi, K.; Karjalainen, A.; Korpela, A.; Tuuva, T.; Besancon, M.; Choudhury, S.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Malcles, J.; Millischer, L.; Nayak, A.; Rander, J.; Rosowsky, A.; Shreyber, I.; Titov, M.; Baffioni, S.; Beaudette, F.; Benhabib, L.; Bianchini, L.; Bluj, M.; Broutin, C.; Busson, P.; Charlot, C.; Daci, N.; Dahms, T.; Dobrzynski, L.; Granier de Cassagnac, R.; Haguenauer, M.; Miné, P.; Mironov, C.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Paganini, P.; Sabes, D.; Salerno, R.; Sirois, Y.; Veelken, C.; Zabi, A.; Agram, J.-L.; Andrea, J.; Bloch, D.; Bodin, D.; Brom, J.-M.; Cardaci, M.; Chabert, E. C.; Collard, C.; Conte, E.; Drouhin, F.; Ferro, C.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Juillot, P.; Le Bihan, A.-C.; Van Hove, P.; Fassi, F.; Mercier, D.; Beauceron, S.; Beaupere, N.; Bondu, O.; Boudoul, G.; Chasserat, J.; Chierici, R.; Contardo, D.; Depasse, P.; El Mamouni, H.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Kurca, T.; Lethuillier, M.; Mirabito, L.; Perries, S.; Sgandurra, L.; Sordini, V.; Tschudi, Y.; Verdier, P.; Viret, S.; Tsamalaidze, Z.; Anagnostou, G.; Autermann, C.; Beranek, S.; Edelhoff, M.; Feld, L.; Heracleous, N.; Hindrichs, O.; Jussen, R.; Klein, K.; Merz, J.; Ostapchuk, A.; Perieanu, A.; Raupach, F.; Sammet, J.; Schael, S.; Sprenger, D.; Weber, H.; Wittmer, B.; Zhukov, V.; Ata, M.; Caudron, J.; Dietz-Laursonn, E.; Duchardt, D.; Erdmann, M.; Fischer, R.; Güth, A.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Klingebiel, D.; Kreuzer, P.; Merschmeyer, M.; Meyer, A.; Olschewski, M.; Papacz, P.; Pieta, H.; Reithler, H.; Schmitz, S. A.; Sonnenschein, L.; Steggemann, J.; Teyssier, D.; Weber, M.; Bontenackels, M.; Cherepanov, V.; Erdogan, Y.; Flügge, G.; Geenen, H.; Geisler, M.; Haj Ahmad, W.; Hoehle, F.; Kargoll, B.; Kress, T.; Kuessel, Y.; Lingemann, J.; Nowack, A.; Perchalla, L.; Pooth, O.; Sauerland, P.; Stahl, A.; Aldaya Martin, M.; Behr, J.; Behrenhoff, W.; Behrens, U.; Bergholz, M.; Bethani, A.; Borras, K.; Burgmeier, A.; Cakir, A.; Calligaris, L.; Campbell, A.; Castro, E.; Costanza, F.; Dammann, D.; Diez Pardos, C.; Eckerlin, G.; Eckstein, D.; Flucke, G.; Geiser, A.; Glushkov, I.; Gunnellini, P.; Habib, S.; Hauk, J.; Hellwig, G.; Jung, H.; Kasemann, M.; Katsas, P.; Kleinwort, C.; Kluge, H.; Knutsson, A.; Krämer, M.; Krücker, D.; Kuznetsova, E.; Lange, W.; Lohmann, W.; Lutz, B.; Mankel, R.; Marfin, I.; Marienfeld, M.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mnich, J.; Mussgiller, A.; Naumann-Emme, S.; Novgorodova, O.; Olzem, J.; Perrey, H.; Petrukhin, A.; Pitzl, D.; Raspereza, A.; Ribeiro Cipriano, P. M.; Riedl, C.; Ron, E.; Rosin, M.; Salfeld-Nebgen, J.; Schmidt, R.; Schoerner-Sadenius, T.; Sen, N.; Spiridonov, A.; Stein, M.; Walsh, R.; Wissing, C.; Blobel, V.; Draeger, J.; Enderle, H.; Erfle, J.; Gebbert, U.; Görner, M.; Hermanns, T.; Höing, R. S.; Kaschube, K.; Kaussen, G.; Kirschenmann, H.; Klanner, R.; Lange, J.; Mura, B.; Nowak, F.; Peiffer, T.; Pietsch, N.; Rathjens, D.; Sander, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Schröder, M.; Schum, T.; Seidel, M.; Sola, V.; Stadie, H.; Steinbrück, G.; Thomsen, J.; Vanelderen, L.; Barth, C.; Berger, J.; Böser, C.; Chwalek, T.; De Boer, W.; Descroix, A.; Dierlamm, A.; Feindt, M.; Guthoff, M.; Hackstein, C.; Hartmann, F.; Hauth, T.; Heinrich, M.; Held, H.; Hoffmann, K. H.; Husemann, U.; Katkov, I.; Komaragiri, J. R.; Lobelle Pardo, P.; Martschei, D.; Mueller, S.; Müller, Th.; Niegel, M.; Nürnberg, A.; Oberst, O.; Oehler, A.; Ott, J.; Quast, G.; Rabbertz, K.; Ratnikov, F.; Ratnikova, N.; Röcker, S.; Schilling, F.-P.; Schott, G.; Simonis, H. J.; Stober, F. M.; Troendle, D.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weiler, T.; Zeise, M.; Daskalakis, G.; Geralis, T.; Kesisoglou, S.; Kyriakis, A.; Loukas, D.; Manolakos, I.; Markou, A.; Markou, C.; Mavrommatis, C.; Ntomari, E.; Gouskos, L.; Mertzimekis, T. J.; Panagiotou, A.; Saoulidou, N.; Evangelou, I.; Foudas, C.; Kokkas, P.; Manthos, N.; Papadopoulos, I.; Patras, V.; Bencze, G.; Hajdu, C.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Beni, N.; Czellar, S.; Molnar, J.; Palinkas, J.; Szillasi, Z.; Karancsi, J.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Beri, S. B.; Bhatnagar, V.; Dhingra, N.; Gupta, R.; Kaur, M.; Mehta, M. Z.; Nishu, N.; Saini, L. K.; Sharma, A.; Singh, J. B.; Kumar, Ashok; Kumar, Arun; Ahuja, S.; Bhardwaj, A.; Choudhary, B. C.; Malhotra, S.; Naimuddin, M.; Ranjan, K.; Sharma, V.; Shivpuri, R. K.; Banerjee, S.; Bhattacharya, S.; Dutta, S.; Gomber, B.; Jain, Sa.; Jain, Sh.; Khurana, R.; Sarkar, S.; Sharan, M.; Abdulsalam, A.; Choudhury, R. K.; Dutta, D.; Kailas, S.; Kumar, V.; Mehta, P.; Mohanty, A. K.; Pant, L. M.; Shukla, P.; Aziz, T.; Ganguly, S.; Guchait, M.; Maity, M.; Majumder, G.; Mazumdar, K.; Mohanty, G. B.; Parida, B.; Sudhakar, K.; Wickramage, N.; Banerjee, S.; Dugad, S.; Arfaei, H.; Bakhshiansohi, H.; Etesami, S. M.; Fahim, A.; Hashemi, M.; Hesari, H.; Jafari, A.; Khakzad, M.; Mohammadi Najafabadi, M.; Paktinat Mehdiabadi, S.; Safarzadeh, B.; Zeinali, M.; Abbrescia, M.; Barbone, L.; Calabria, C.; Chhibra, S. S.; Colaleo, A.; Creanza, D.; De Filippis, N.; De Palma, M.; Fiore, L.; Iaselli, G.; Lusito, L.; Maggi, G.; Maggi, M.; Marangelli, B.; My, S.; Nuzzo, S.; Pacifico, N.; Pompili, A.; Pugliese, G.; Selvaggi, G.; Silvestris, L.; Singh, G.; Venditti, R.; Zito, G.; Abbiendi, G.; Benvenuti, A. C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Meneghelli, M.; Montanari, A.; Navarria, F. L.; Odorici, F.; Perrotta, A.; Primavera, F.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Travaglini, R.; Albergo, S.; Cappello, G.; Chiorboli, M.; Costa, S.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Frosali, S.; Gallo, E.; Gonzi, S.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Tropiano, A.; Benussi, L.; Bianco, S.; Colafranceschi, S.; Fabbri, F.; Piccolo, D.; Fabbricatore, P.; Musenich, R.; Tosi, S.; Benaglia, A.; De Guio, F.; Di Matteo, L.; Fiorendi, S.; Gennai, S.; Ghezzi, A.; Malvezzi, S.; Manzoni, R. A.; Martelli, A.; Massironi, A.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Ragazzi, S.; Redaelli, N.; Sala, S.; Tabarelli de Fatis, T.; Buontempo, S.; Carrillo Montoya, C. A.; Cavallo, N.; De Cosa, A.; Dogangun, O.; Fabozzi, F.; Iorio, A. O. M.; Lista, L.; Meola, S.; Merola, M.; Paolucci, P.; Azzi, P.; Bacchetta, N.; Bisello, D.; Branca, A.; Carlin, R.; Checchia, P.; Dorigo, T.; Gasparini, F.; Gasparini, U.; Gozzelino, A.; Kanishchev, K.; Lacaprara, S.; Lazzizzera, I.; Margoni, M.; Meneguzzo, A. T.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Simonetto, F.; Torassa, E.; Tosi, M.; Vanini, S.; Zotto, P.; Zucchetta, A.; Zumerle, G.; Gabusi, M.; Ratti, S. P.; Riccardi, C.; Torre, P.; Vitulo, P.; Biasini, M.; Bilei, G. M.; Fanò, L.; Lariccia, P.; Mantovani, G.; Menichelli, M.; Nappi, A.; Romeo, F.; Saha, A.; Santocchia, A.; Spiezia, A.; Taroni, S.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Broccolo, G.; Castaldi, R.; D'Agnolo, R. T.; Dell'Orso, R.; Fiori, F.; Foà, L.; Giassi, A.; Kraan, A.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Serban, A. T.; Spagnolo, P.; Squillacioti, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; Del Re, D.; Diemoz, M.; Fanelli, C.; Grassi, M.; Longo, E.; Meridiani, P.; Micheli, F.; Nourbakhsh, S.; Organtini, G.; Paramatti, R.; Rahatlou, S.; Sigamani, M.; Soffi, L.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Biino, C.; Cartiglia, N.; Costa, M.; Demaria, N.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Musich, M.; Obertino, M. M.; Pastrone, N.; Pelliccioni, M.; Potenza, A.; Romero, A.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Vilela Pereira, A.; Belforte, S.; Candelise, V.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; Gobbo, B.; Marone, M.; Montanino, D.; Penzo, A.; Schizzi, A.; Heo, S. G.; Kim, T. Y.; Nam, S. K.; Chang, S.; Kim, D. H.; Kim, G. N.; Kong, D. J.; Park, H.; Ro, S. R.; Son, D. C.; Son, T.; Kim, J. Y.; Kim, Zero J.; Song, S.; Choi, S.; Gyun, D.; Hong, B.; Jo, M.; Kim, H.; Kim, T. J.; Lee, K. S.; Moon, D. H.; Park, S. K.; Choi, M.; Kim, J. H.; Park, C.; Park, I. C.; Park, S.; Ryu, G.; Cho, Y.; Choi, Y.; Choi, Y. K.; Goh, J.; Kim, M. S.; Kwon, E.; Lee, B.; Lee, J.; Lee, S.; Seo, H.; Yu, I.; Bilinskas, M. J.; Grigelionis, I.; Janulis, M.; Juodagalvis, A.; Castilla-Valdez, H.; De La Cruz-Burelo, E.; Heredia-de La Cruz, I.; Lopez-Fernandez, R.; Magaña Villalba, R.; Martínez-Ortega, J.; Sánchez-Hernández, A.; Villasenor-Cendejas, L. M.; Carrillo Moreno, S.; Vazquez Valencia, F.; Salazar Ibarguen, H. A.; Casimiro Linares, E.; Morelos Pineda, A.; Reyes-Santos, M. A.; Krofcheck, D.; Bell, A. J.; Butler, P. H.; Doesburg, R.; Reucroft, S.; Silverwood, H.; Ahmad, M.; Ansari, M. H.; Asghar, M. I.; Hoorani, H. R.; Khalid, S.; Khan, W. A.; Khurshid, T.; Qazi, S.; Shah, M. A.; Shoaib, M.; Bialkowska, H.; Boimska, B.; Frueboes, T.; Gokieli, R.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Wrochna, G.; Zalewski, P.; Brona, G.; Bunkowski, K.; Cwiok, M.; Dominik, W.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Almeida, N.; Bargassa, P.; David, A.; Faccioli, P.; Ferreira Parracho, P. G.; Gallinaro, M.; Seixas, J.; Varela, J.; Vischia, P.; Bunin, P.; Gavrilenko, M.; Golutvin, I.; Gorbunov, I.; Karjavin, V.; Konoplyanikov, V.; Kozlov, G.; Lanev, A.; Malakhov, A.; Moisenz, P.; Palichik, V.; Perelygin, V.; Savina, M.; Shmatov, S.; Smirnov, V.; Volodko, A.; Zarubin, A.; Evstyukhin, S.; Golovtsov, V.; Ivanov, Y.; Kim, V.; Levchenko, P.; Murzin, V.; Oreshkin, V.; Smirnov, I.; Sulimov, V.; Uvarov, L.; Vavilov, S.; Vorobyev, A.; Vorobyev, An.; Andreev, Yu.; Dermenev, A.; Gninenko, S.; Golubev, N.; Kirsanov, M.; Krasnikov, N.; Matveev, V.; Pashenkov, A.; Tlisov, D.; Toropin, A.; Epshteyn, V.; Erofeeva, M.; Gavrilov, V.; Kossov, M.; Lychkovskaya, N.; Popov, V.; Safronov, G.; Semenov, S.; Stolin, V.; Vlasov, E.; Zhokin, A.; Belyaev, A.; Boos, E.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Markina, A.; Obraztsov, S.; Perfilov, M.; Petrushanko, S.; Popov, A.; Sarycheva, L.; Savrin, V.; Snigirev, A.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Leonidov, A.; Mesyats, G.; Rusakov, S. V.; Vinogradov, A.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Grishin, V.; Kachanov, V.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Djordjevic, M.; Ekmedzic, M.; Krpic, D.; Milosevic, J.; Aguilar-Benitez, M.; Alcaraz Maestre, J.; Arce, P.; Battilana, C.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; De La Cruz, B.; Delgado Peris, A.; Domínguez Vázquez, D.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Ferrando, A.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Merino, G.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Santaolalla, J.; Soares, M. S.; Willmott, C.; Albajar, C.; Codispoti, G.; de Trocóniz, J. F.; Brun, H.; Cuevas, J.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; Lloret Iglesias, L.; Piedra Gomez, J.; Brochero Cifuentes, J. A.; Cabrillo, I. J.; Calderon, A.; Chuang, S. H.; Duarte Campderros, J.; Felcini, M.; Fernandez, M.; Gomez, G.; Gonzalez Sanchez, J.; Graziano, A.; Jorda, C.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Matorras, F.; Munoz Sanchez, F. J.; Rodrigo, T.; Rodríguez-Marrero, A. Y.; Ruiz-Jimeno, A.; Scodellaro, L.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Benitez, J. F.; Bernet, C.; Bianchi, G.; Bloch, P.; Bocci, A.; Bonato, A.; Botta, C.; Breuker, H.; Camporesi, T.; Cerminara, G.; Christiansen, T.; Coarasa Perez, J. A.; D'Enterria, D.; Dabrowski, A.; De Roeck, A.; Di Guida, S.; Dobson, M.; Dupont-Sagorin, N.; Elliott-Peisert, A.; Frisch, B.; Funk, W.; Georgiou, G.; Giffels, M.; Gigi, D.; Gill, K.; Giordano, D.; Girone, M.; Giunta, M.; Glege, F.; Gomez-Reino Garrido, R.; Govoni, P.; Gowdy, S.; Guida, R.; Hansen, M.; Harris, P.; Hartl, C.; Harvey, J.; Hegner, B.; Hinzmann, A.; Innocente, V.; Janot, P.; Kaadze, K.; Karavakis, E.; Kousouris, K.; Lecoq, P.; Lee, Y.-J.; Lenzi, P.; Lourenço, C.; Magini, N.; Mäki, T.; Malberti, M.; Malgeri, L.; Mannelli, M.; Masetti, L.; Meijers, F.; Mersi, S.; Meschi, E.; Moser, R.; Mozer, M. U.; Mulders, M.; Musella, P.; Nesvold, E.; Orimoto, T.; Orsini, L.; Palencia Cortezon, E.; Perez, E.; Perrozzi, L.; Petrilli, A.; Pfeiffer, A.; Pierini, M.; Pimiä, M.; Piparo, D.; Polese, G.; Quertenmont, L.; Racz, A.; Reece, W.; Rodrigues Antunes, J.; Rolandi, G.; Rovelli, C.; Rovere, M.; Sakulin, H.; Santanastasio, F.; Schäfer, C.; Schwick, C.; Segoni, I.; Sekmen, S.; Sharma, A.; Siegrist, P.; Silva, P.; Simon, M.; Sphicas, P.; Spiga, D.; Tsirou, A.; Veres, G. I.; Vlimant, J. R.; Wöhri, H. K.; Worm, S. D.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Gabathuler, K.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; König, S.; Kotlinski, D.; Langenegger, U.; Meier, F.; Renker, D.; Rohe, T.; Sibille, J.; Bäni, L.; Bortignon, P.; Buchmann, M. A.; Casal, B.; Chanon, N.; Deisher, A.; Dissertori, G.; Dittmar, M.; Donegà, M.; Dünser, M.; Eugster, J.; Freudenreich, K.; Grab, C.; Hits, D.; Lecomte, P.; Lustermann, W.; Marini, A. C.; Martinez Ruiz del Arbol, P.; Mohr, N.; Moortgat, F.; Nägeli, C.; Nef, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pape, L.; Pauss, F.; Peruzzi, M.; Ronga, F. J.; Rossini, M.; Sala, L.; Sanchez, A. K.; Starodumov, A.; Stieger, B.; Takahashi, M.; Tauscher, L.; Thea, A.; Theofilatos, K.; Treille, D.; Urscheler, C.; Wallny, R.; Weber, H. A.; Wehrli, L.; Amsler, C.; Chiochia, V.; De Visscher, S.; Favaro, C.; Ivova Rikova, M.; Millan Mejias, B.; Otiougova, P.; Robmann, P.; Snoek, H.; Tupputi, S.; Verzetti, M.; Chang, Y. H.; Chen, K. H.; Kuo, C. M.; Li, S. W.; Lin, W.; Liu, Z. K.; Lu, Y. J.; Mekterovic, D.; Singh, A. P.; Volpe, R.; Yu, S. S.; Bartalini, P.; Chang, P.; Chang, Y. H.; Chang, Y. W.; Chao, Y.; Chen, K. F.; Dietz, C.; Grundler, U.; Hou, W.-S.; Hsiung, Y.; Kao, K. Y.; Lei, Y. J.; Lu, R.-S.; Majumder, D.; Petrakou, E.; Shi, X.; Shiu, J. G.; Tzeng, Y. M.; Wan, X.; Wang, M.; Asavapibhop, B.; Srimanobhas, N.; Adiguzel, A.; Bakirci, M. N.; Cerci, S.; Dozen, C.; Dumanoglu, I.; Eskut, E.; Girgis, S.; Gokbulut, G.; Gurpinar, E.; Hos, I.; Kangal, E. E.; Karaman, T.; Karapinar, G.; Kayis Topaksu, A.; Onengut, G.; Ozdemir, K.; Ozturk, S.; Polatoz, A.; Sogut, K.; Sunar Cerci, D.; Tali, B.; Topakli, H.; Vergili, L. N.; Vergili, M.; Akin, I. V.; Aliev, T.; Bilin, B.; Bilmis, S.; Deniz, M.; Gamsizkan, H.; Guler, A. M.; Ocalan, K.; Ozpineci, A.; Serin, M.; Sever, R.; Surat, U. E.; Yalvac, M.; Yildirim, E.; Zeyrek, M.; Gülmez, E.; Isildak, B.; Kaya, M.; Kaya, O.; Ozkorucuklu, S.; Sonmez, N.; Cankocak, K.; Levchuk, L.; Bostock, F.; Brooke, J. J.; Clement, E.; Cussans, D.; Flacher, H.; Frazier, R.; Goldstein, J.; Grimes, M.; Heath, G. P.; Heath, H. F.; Kreczko, L.; Metson, S.; Newbold, D. M.; Nirunpong, K.; Poll, A.; Senkin, S.; Smith, V. J.; Williams, T.; Basso, L.; Bell, K. W.; Belyaev, A.; Brew, C.; Brown, R. M.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Jackson, J.; Kennedy, B. W.; Olaiya, E.; Petyt, D.; Radburn-Smith, B. C.; Shepherd-Themistocleous, C. H.; Tomalin, I. R.; Womersley, W. J.; Bainbridge, R.; Ball, G.; Beuselinck, R.; Buchmuller, O.; Colling, D.; Cripps, N.; Cutajar, M.; Dauncey, P.; Davies, G.; Della Negra, M.; Ferguson, W.; Fulcher, J.; Futyan, D.; Gilbert, A.; Guneratne Bryer, A.; Hall, G.; Hatherell, Z.; Hays, J.; Iles, G.; Jarvis, M.; Karapostoli, G.; Lyons, L.; Magnan, A.-M.; Marrouche, J.; Mathias, B.; Nandi, R.; Nash, J.; Nikitenko, A.; Papageorgiou, A.; Pela, J.; Pesaresi, M.; Petridis, K.; Pioppi, M.; Raymond, D. M.; Rogerson, S.; Rose, A.; Ryan, M. J.; Seez, C.; Sharp, P.; Sparrow, A.; Stoye, M.; Tapper, A.; Vazquez Acosta, M.; Virdee, T.; Wakefield, S.; Wardle, N.; Whyntie, T.; Chadwick, M.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Leggat, D.; Leslie, D.; Martin, W.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Hatakeyama, K.; Liu, H.; Scarborough, T.; Charaf, O.; Henderson, C.; Rumerio, P.; Avetisyan, A.; Bose, T.; Fantasia, C.; Heister, A.; St. John, J.; Lawson, P.; Lazic, D.; Rohlf, J.; Sperka, D.; Sulak, L.; Alimena, J.; Bhattacharya, S.; Cutts, D.; Demiragli, Z.; Ferapontov, A.; Heintz, U.; Jabeen, S.; Kukartsev, G.; Laird, E.; Landsberg, G.; Luk, M.; Narain, M.; Nguyen, D.; Segala, M.; Sinthuprasith, T.; Speer, T.; Tsang, K. V.; Breedon, R.; Breto, G.; Calderon De La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Dolen, J.; Erbacher, R.; Gardner, M.; Houtz, R.; Ko, W.; Kopecky, A.; Lander, R.; Mall, O.; Miceli, T.; Pellett, D.; Ricci-tam, F.; Rutherford, B.; Searle, M.; Smith, J.; Squires, M.; Tripathi, M.; Vasquez Sierra, R.; Yohay, R.; Andreev, V.; Cline, D.; Cousins, R.; Duris, J.; Erhan, S.; Everaerts, P.; Farrell, C.; Hauser, J.; Ignatenko, M.; Jarvis, C.; Plager, C.; Rakness, G.; Schlein, P.; Traczyk, P.; Valuev, V.; Weber, M.; Babb, J.; Clare, R.; Dinardo, M. E.; Ellison, J.; Gary, J. W.; Giordano, F.; Hanson, G.; Jeng, G. Y.; Liu, H.; Long, O. R.; Luthra, A.; Nguyen, H.; Paramesvaran, S.; Sturdy, J.; Sumowidagdo, S.; Wilken, R.; Wimpenny, S.; Andrews, W.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; Evans, D.; Golf, F.; Holzner, A.; Kelley, R.; Lebourgeois, M.; Letts, J.; Macneill, I.; Mangano, B.; Padhi, S.; Palmer, C.; Petrucciani, G.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Sudano, E.; Tadel, M.; Tu, Y.; Vartak, A.; Wasserbaech, S.; Würthwein, F.; Yagil, A.; Yoo, J.; Barge, D.; Bellan, R.; Campagnari, C.; D'Alfonso, M.; Danielson, T.; Flowers, K.; Geffert, P.; Incandela, J.; Justus, C.; Kalavase, P.; Koay, S. A.; Kovalskyi, D.; Krutelyov, V.; Lowette, S.; Mccoll, N.; Pavlunin, V.; Rebassoo, F.; Ribnik, J.; Richman, J.; Rossin, R.; Stuart, D.; To, W.; West, C.; Apresyan, A.; Bornheim, A.; Chen, Y.; Di Marco, E.; Duarte, J.; Gataullin, M.; Ma, Y.; Mott, A.; Newman, H. B.; Rogan, C.; Spiropulu, M.; Timciuc, V.; Veverka, J.; Wilkinson, R.; Xie, S.; Yang, Y.; Zhu, R. Y.; Akgun, B.; Azzolini, V.; Calamba, A.; Carroll, R.; Ferguson, T.; Iiyama, Y.; Jang, D. W.; Liu, Y. F.; Paulini, M.; Vogel, H.; Vorobiev, I.; Cumalat, J. P.; Drell, B. R.; Ford, W. T.; Gaz, A.; Luiggi Lopez, E.; Smith, J. G.; Stenson, K.; Ulmer, K. A.; Wagner, S. R.; Alexander, J.; Chatterjee, A.; Eggert, N.; Gibbons, L. K.; Heltsley, B.; Khukhunaishvili, A.; Kreis, B.; Mirman, N.; Nicolas Kaufman, G.; Patterson, J. R.; Ryd, A.; Salvati, E.; Sun, W.; Teo, W. D.; Thom, J.; Thompson, J.; Tucker, J.; Vaughan, J.; Weng, Y.; Winstrom, L.; Wittich, P.; Winn, D.; Abdullin, S.; Albrow, M.; Anderson, J.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bloch, I.; Burkett, K.; Butler, J. N.; Chetluru, V.; Cheung, H. W. K.; Chlebana, F.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gao, Y.; Green, D.; Gutsche, O.; Hanlon, J.; Harris, R. M.; Hirschauer, J.; Hooberman, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Kilminster, B.; Klima, B.; Kunori, S.; Kwan, S.; Leonidopoulos, C.; Linacre, J.; Lincoln, D.; Lipton, R.; Lykken, J.; Maeshima, K.; Marraffino, J. M.; Maruyama, S.; Mason, D.; McBride, P.; Mishra, K.; Mrenna, S.; Musienko, Y.; Newman-Holmes, C.; O'Dell, V.; Prokofyev, O.; Sexton-Kennedy, E.; Sharma, S.; Spalding, W. J.; Spiegel, L.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vidal, R.; Whitmore, J.; Wu, W.; Yang, F.; Yumiceva, F.; Yun, J. C.; Acosta, D.; Avery, P.; Bourilkov, D.; Chen, M.; Cheng, T.; Das, S.; De Gruttola, M.; Di Giovanni, G. P.; Dobur, D.; Drozdetskiy, A.; Field, R. D.; Fisher, M.; Fu, Y.; Furic, I. K.; Gartner, J.; Hugon, J.; Kim, B.; Konigsberg, J.; Korytov, A.; Kropivnitskaya, A.; Kypreos, T.; Low, J. F.; Matchev, K.; Milenovic, P.; Mitselmakher, G.; Muniz, L.; Park, M.; Remington, R.; Rinkevicius, A.; Sellers, P.; Skhirtladze, N.; Snowball, M.; Yelton, J.; Zakaria, M.; Gaultney, V.; Hewamanage, S.; Lebolo, L. M.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Adams, T.; Askew, A.; Bochenek, J.; Chen, J.; Diamond, B.; Gleyzer, S. V.; Haas, J.; Hagopian, S.; Hagopian, V.; Jenkins, M.; Johnson, K. F.; Prosper, H.; Veeraraghavan, V.; Weinberg, M.; Baarmand, M. M.; Dorney, B.; Hohlmann, M.; Kalakhety, H.; Vodopiyanov, I.; Adams, M. R.; Anghel, I. M.; Apanasevich, L.; Bai, Y.; Bazterra, V. E.; Betts, R. R.; Bucinskaite, I.; Callner, J.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Khalatyan, S.; Lacroix, F.; Malek, M.; O'Brien, C.; Silkworth, C.; Strom, D.; Turner, P.; Varelas, N.; Akgun, U.; Albayrak, E. A.; Bilki, B.; Clarida, W.; Duru, F.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Newsom, C. R.; Norbeck, E.; Onel, Y.; Ozok, F.; Sen, S.; Tan, P.; Tiras, E.; Wetzel, J.; Yetkin, T.; Yi, K.; Barnett, B. A.; Blumenfeld, B.; Bolognesi, S.; Fehling, D.; Giurgiu, G.; Gritsan, A. V.; Guo, Z. J.; Hu, G.; Maksimovic, P.; Rappoccio, S.; Swartz, M.; Whitbeck, A.; Baringer, P.; Bean, A.; Benelli, G.; Kenny, R. P., Iii; Murray, M.; Noonan, D.; Sanders, S.; Stringer, R.; Tinti, G.; Wood, J. S.; Zhukova, V.; Barfuss, A. F.; Bolton, T.; Chakaberia, I.; Ivanov, A.; Khalil, S.; Makouski, M.; Maravin, Y.; Shrestha, S.; Svintradze, I.; Gronberg, J.; Lange, D.; Wright, D.; Baden, A.; Boutemeur, M.; Calvert, B.; Eno, S. C.; Gomez, J. A.; Hadley, N. J.; Kellogg, R. G.; Kirn, M.; Kolberg, T.; Lu, Y.; Marionneau, M.; Mignerey, A. C.; Pedro, K.; Peterman, A.; Skuja, A.; Temple, J.; Tonjes, M. B.; Tonwar, S. C.; Twedt, E.; Apyan, A.; Bauer, G.; Bendavid, J.; Busza, W.; Butz, E.; Cali, I. A.; Chan, M.; Dutta, V.; Gomez Ceballos, G.; Goncharov, M.; Hahn, K. A.; Kim, Y.; Klute, M.; Krajczar, K.; Luckey, P. D.; Ma, T.; Nahn, S.; Paus, C.; Ralph, D.; Roland, C.; Roland, G.; Rudolph, M.; Stephans, G. S. F.; Stöckli, F.; Sumorok, K.; Sung, K.; Velicanu, D.; Wenger, E. A.; Wolf, R.; Wyslouch, B.; Yang, M.; Yilmaz, Y.; Yoon, A. S.; Zanetti, M.; Cooper, S. I.; Dahmes, B.; De Benedetti, A.; Franzoni, G.; Gude, A.; Kao, S. C.; Klapoetke, K.; Kubota, Y.; Mans, J.; Pastika, N.; Rusack, R.; Sasseville, M.; Singovsky, A.; Tambe, N.; Turkewitz, J.; Cremaldi, L. M.; Kroeger, R.; Perera, L.; Rahmat, R.; Sanders, D. A.; Avdeeva, E.; Bloom, K.; Bose, S.; Butt, J.; Claes, D. R.; Dominguez, A.; Eads, M.; Keller, J.; Kravchenko, I.; Lazo-Flores, J.; Malbouisson, H.; Malik, S.; Snow, G. R.; Godshalk, A.; Iashvili, I.; Jain, S.; Kharchilava, A.; Kumar, A.; Alverson, G.; Barberis, E.; Baumgartel, D.; Chasco, M.; Haley, J.; Nash, D.; Trocino, D.; Wood, D.; Zhang, J.; Anastassov, A.; Kubik, A.; Mucia, N.; Odell, N.; Ofierzynski, R. A.; Pollack, B.; Pozdnyakov, A.; Schmitt, M.; Stoynev, S.; Velasco, M.; Won, S.; Antonelli, L.; Berry, D.; Brinkerhoff, A.; Chan, K. M.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kolb, J.; Lannon, K.; Luo, W.; Lynch, S.; Marinelli, N.; Morse, D. M.; Pearson, T.; Planer, M.; Ruchti, R.; Slaunwhite, J.; Valls, N.; Wayne, M.; Wolf, M.; Bylsma, B.; Durkin, L. S.; Hill, C.; Hughes, R.; Kotov, K.; Ling, T. Y.; Puigh, D.; Rodenburg, M.; Vuosalo, C.; Williams, G.; Winer, B. L.; Adam, N.; Berry, E.; Elmer, P.; Gerbaudo, D.; Halyo, V.; Hebda, P.; Hegeman, J.; Hunt, A.; Jindal, P.; Lopes Pegna, D.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Piroué, P.; Quan, X.; Raval, A.; Safdi, B.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zuranski, A.; Brownson, E.; Lopez, A.; Mendez, H.; Ramirez Vargas, J. E.; Alagoz, E.; Barnes, V. E.; Benedetti, D.; Bolla, G.; Bortoletto, D.; De Mattia, M.; Everett, A.; Hu, Z.; Jones, M.; Koybasi, O.; Kress, M.; Laasanen, A. T.; Leonardo, N.; Maroussov, V.; Merkel, P.; Miller, D. H.; Neumeister, N.; Shipsey, I.; Silvers, D.; Svyatkovskiy, A.; Vidal Marono, M.; Yoo, H. D.; Zablocki, J.; Zheng, Y.; Guragain, S.; Parashar, N.; Adair, A.; Boulahouache, C.; Ecklund, K. M.; Geurts, F. J. M.; Li, W.; Padley, B. P.; Redjimi, R.; Roberts, J.; Zabel, J.; Betchart, B.; Bodek, A.; Chung, Y. S.; Covarelli, R.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Garcia-Bellido, A.; Goldenzweig, P.; Han, J.; Harel, A.; Miner, D. C.; Vishnevskiy, D.; Zielinski, M.; Bhatti, A.; Ciesielski, R.; Demortier, L.; Goulianos, K.; Lungu, G.; Malik, S.; Mesropian, C.; Arora, S.; Barker, A.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Duggan, D.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Lath, A.; Panwalkar, S.; Park, M.; Patel, R.; Rekovic, V.; Robles, J.; Rose, K.; Salur, S.; Schnetzer, S.; Seitz, C.; Somalwar, S.; Stone, R.; Thomas, S.; Cerizza, G.; Hollingsworth, M.; Spanier, S.; Yang, Z. C.; York, A.; Eusebi, R.; Flanagan, W.; Gilmore, J.; Kamon, T.; Khotilovich, V.; Montalvo, R.; Osipenkov, I.; Pakhotin, Y.; Perloff, A.; Roe, J.; Safonov, A.; Sakuma, T.; Sengupta, S.; Suarez, I.; Tatarinov, A.; Toback, D.; Akchurin, N.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Jeong, C.; Kovitanggoon, K.; Lee, S. W.; Libeiro, T.; Roh, Y.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Florez, C.; Greene, S.; Gurrola, A.; Johns, W.; Kurt, P.; Maguire, C.; Melo, A.; Sharma, M.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Arenton, M. W.; Balazs, M.; Boutle, S.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Lin, C.; Neu, C.; Wood, J.; Gollapinni, S.; Harr, R.; Karchin, P. E.; Kottachchi Kankanamge Don, C.; Lamichhane, P.; Sakharov, A.; Anderson, M.; Belknap, D.; Borrello, L.; Carlsmith, D.; Cepeda, M.; Dasu, S.; Friis, E.; Gray, L.; Grogg, K. S.; Grothe, M.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Klukas, J.; Lanaro, A.; Lazaridis, C.; Leonard, J.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Palmonari, F.; Pierro, G. A.; Ross, I.; Savin, A.; Smith, W. H.; Swanson, J.

2013-05-01

A search is presented for free heavy long-lived fractionally charged particles produced in pp collisions at s=7TeV. The data sample was recorded by the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0fb-1. Candidate fractionally charged particles are identified by selecting tracks with associated low charge measurements in the silicon tracking detector. Observations are found to be consistent with expectations for background processes. The results of the search are used to set upper limits on the cross section for pair production of fractionally charged, massive spin-1/2 particles that are neutral under SU(3)C and SU(2)L. We exclude at 95% confidence level such particles with electric charge ±2e/3 with masses below 310 GeV, and those with charge ±e/3 with masses below 140 GeV.

Numerical Study on the Particle Trajectory Tracking in a Micro-UV Bio-Fluorescence Sensor.

PubMed

Byeon, Sun-Seok; Cho, Moon-Young; Lee, Jong-Chul; Kim, Youn-Jea

2015-03-01

A micro-UV bio-fluorescence sensor was developed to detect primary biological aerosols including bacteria, bacterial spores, fungal spores, pollens, viruses, algae, etc. In order to effectively detect the bio-particles in a micro-UV bio-fluorescence sensor, numerical calculations were performed to adjust for appropriate flow conditions of the sensor by regulating the sample aerosols and sheath flow. In particular, a CFD-based model of hydrodynamic processes was developed by computing the trajectory of particles using commercially available ANSYS CFX-14 software and the Lagrangian tracking model. The established model was evaluated with regard to the variation of sheath flow rate and particle size. Results showed that the sheath flow was changed rapidly at the end of nozzle tip, but the sample particles moved near the center of aerosol jet for aerodynamic focusing with little deviation from the axis.

Search for fractionally charged particles in p p collisions at s = 7 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.

A search is presented for free heavy long-lived fractionally charged particles produced in pp collisions atmore » $$\\sqrt{s}$$ = 7 TeV. The data sample was recorded by the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 inverse femtobarns. Candidate fractionally charged particles are identified by selecting tracks with associated low charge measurements in the silicon tracking detector. Observations are found to be consistent with expectations for background processes. The results of the search are used to set upper limits on the cross section for pair production of fractionally charged, massive spin-1/2 particles that are neutral under SU(3)$$_C$$ and SU(2)$$_L$$. We exclude at 95% confidence level such particles with electric charge $$\\pm$$2e/3 with masses below 310 GeV, and those with charge $$\\pm$$e/3 with masses below 140 GeV.« less

Measuring three-dimensional interaction potentials using optical interference.

PubMed

Mojarad, Nassir; Sandoghdar, Vahid; Krishnan, Madhavi

2013-04-22

We describe the application of three-dimensional (3D) scattering interferometric (iSCAT) imaging to the measurement of spatial interaction potentials for nano-objects in solution. We study electrostatically trapped gold particles in a nanofluidic device and present details on axial particle localization in the presence of a strongly reflecting interface. Our results demonstrate high-speed (~kHz) particle tracking with subnanometer localization precision in the axial and average 2.5 nm in the lateral dimension. A comparison of the measured levitation heights of trapped particles with the calculated values for traps of various geometries reveals good agreement. Our work demonstrates that iSCAT imaging delivers label-free, high-speed and accurate 3D tracking of nano-objects conducive to probing weak and long-range interaction potentials in solution.

Visualizing interactions between Sindbis virus and cells by single particle tracking

NASA Astrophysics Data System (ADS)

Williard, Mary

2005-03-01

Sindbis virus infects both mammalian and insect cells. Though not pathogenic in humans, Sindbis is a model for many mosquito- borne viruses that cause human disease, such as West Nile virus. We have used real-time single particle fluorescence microscopy to observe individual Sindbis virus particles as they infect living cells. Fluorescent labels were incorporated into both the viral coat proteins and the lipid envelope of the virus. Kinetics characteristic of free diffusion in solution, slower diffusion inside cells, attachment to spots on the cell surface, and motor protein transport inside cells have been observed. Dequenching of the membrane label is used to report membrane fusion events during the infection process. Tracking individual viral particles allows multiple pathways to be determined without the requirement of synchronicity.

Avalanches, and evolution of stress and fabric for a cyclically sheared granular material

NASA Astrophysics Data System (ADS)

Wang, Dengming; Bares, Jonathan; Wang, Dong; Behringer, Bob

2015-03-01

Granular materials yield for large enough shear stress, leading to avalanches. We seek to understand the relation between macroscopic avalanches and the the microscopic granular structure. We present an experimental study of a 2D granular material subjected to cyclic pure shear, which we visualized by a photo-elastic technique. We start from a stress-free sample of frictional particles in the shear-jamming regime (ϕS <= ϕ <=ϕJ). We apply multiple cycles of pure shear: shear in one direction, followed by a reversal to the original boundary configuration. The strain is made in small quasi-static steps: after each small step, we obtain polarized and unpolarized images yielding particle-scale forces and locations. Statistical measures of the avalanches are in reasonable agreement with recent mean-field avalanche models by Dahmen et al. (Nature Physics 7, 554 (2011)) The system structure evolves slowly to reduce the stress at the extrema of strain, similar to the relaxation observed by Ren et al. (Phys. Rev. Lett. 110, 018302 (2013)) in a simple shear experiment. To understand how this relaxation occurs, we track the stress and fabric tensors and measures of the strain field over many cycles of shear. Supported by NASA Grant NNX10AU01G, and NSF Grants DMR1206351 and DMS1248071.

Selective counting and sizing of single virus particles using fluorescent aptamer-based nanoparticle tracking analysis.

PubMed

Szakács, Zoltán; Mészáros, Tamás; de Jonge, Marien I; Gyurcsányi, Róbert E

2018-05-30

Detection and counting of single virus particles in liquid samples are largely limited to narrow size distribution of viruses and purified formulations. To address these limitations, here we propose a calibration-free method that enables concurrently the selective recognition, counting and sizing of virus particles as demonstrated through the detection of human respiratory syncytial virus (RSV), an enveloped virus with a broad size distribution, in throat swab samples. RSV viruses were selectively labeled through their attachment glycoproteins (G) with fluorescent aptamers, which further enabled their identification, sizing and counting at the single particle level by fluorescent nanoparticle tracking analysis. The proposed approach seems to be generally applicable to virus detection and quantification. Moreover, it could be successfully applied to detect single RSV particles in swab samples of diagnostic relevance. Since the selective recognition is associated with the sizing of each detected particle, this method enables to discriminate viral elements linked to the virus as well as various virus forms and associations.

Slice of Comet Dust

NASA Image and Video Library

2006-02-21

This image illustrates one of several ways scientists have begun extracting comet particles from NASAa Stardust spacecraft collector. First, a particle and its track are cut out of the collector material, called aerogel.

Tracking quasi-stationary flow of weak fluorescent signals by adaptive multi-frame correlation.

PubMed

Ji, L; Danuser, G

2005-12-01

We have developed a novel cross-correlation technique to probe quasi-stationary flow of fluorescent signals in live cells at a spatial resolution that is close to single particle tracking. By correlating image blocks between pairs of consecutive frames and integrating their correlation scores over multiple frame pairs, uncertainty in identifying a globally significant maximum in the correlation score function has been greatly reduced as compared with conventional correlation-based tracking using the signal of only two consecutive frames. This approach proves robust and very effective in analysing images with a weak, noise-perturbed signal contrast where texture characteristics cannot be matched between only a pair of frames. It can also be applied to images that lack prominent features that could be utilized for particle tracking or feature-based template matching. Furthermore, owing to the integration of correlation scores over multiple frames, the method can handle signals with substantial frame-to-frame intensity variation where conventional correlation-based tracking fails. We tested the performance of the method by tracking polymer flow in actin and microtubule cytoskeleton structures labelled at various fluorophore densities providing imagery with a broad range of signal modulation and noise. In applications to fluorescent speckle microscopy (FSM), where the fluorophore density is sufficiently low to reveal patterns of discrete fluorescent marks referred to as speckles, we combined the multi-frame correlation approach proposed above with particle tracking. This hybrid approach allowed us to follow single speckles robustly in areas of high speckle density and fast flow, where previously published FSM analysis methods were unsuccessful. Thus, we can now probe cytoskeleton polymer dynamics in living cells at an entirely new level of complexity and with unprecedented detail.

CR-39 track detector calibration for H, He, and C ions from 0.1-0.5 MeV up to 5 MeV for laser-induced nuclear fusion product identification.

PubMed

Baccou, C; Yahia, V; Depierreux, S; Neuville, C; Goyon, C; Consoli, F; De Angelis, R; Ducret, J E; Boutoux, G; Rafelski, J; Labaune, C

2015-08-01

Laser-accelerated ion beams can be used in many applications and, especially, to initiate nuclear reactions out of thermal equilibrium. We have experimentally studied aneutronic fusion reactions induced by protons accelerated by the Target Normal Sheath Acceleration mechanism, colliding with a boron target. Such experiments require a rigorous method to identify the reaction products (alpha particles) collected in detectors among a few other ion species such as protons or carbon ions, for example. CR-39 track detectors are widely used because they are mostly sensitive to ions and their efficiency is near 100%. We present a complete calibration of CR-39 track detector for protons, alpha particles, and carbon ions. We give measurements of their track diameters for energy ranging from hundreds of keV to a few MeV and for etching times between 1 and 8 h. We used these results to identify alpha particles in our experiments on proton-boron fusion reactions initiated by laser-accelerated protons. We show that their number clearly increases when the boron fuel is preformed in a plasma state.

A new fast scanning system for the measurement of large angle tracks in nuclear emulsions

NASA Astrophysics Data System (ADS)

Alexandrov, A.; Buonaura, A.; Consiglio, L.; D'Ambrosio, N.; De Lellis, G.; Di Crescenzo, A.; Di Marco, N.; Galati, G.; Lauria, A.; Montesi, M. C.; Pupilli, F.; Shchedrina, T.; Tioukov, V.; Vladymyrov, M.

2015-11-01

Nuclear emulsions have been widely used in particle physics to identify new particles through the observation of their decays thanks to their unique spatial resolution. Nevertheless, before the advent of automatic scanning systems, the emulsion analysis was very demanding in terms of well trained manpower. Due to this reason, they were gradually replaced by electronic detectors, until the '90s, when automatic microscopes started to be developed in Japan and in Europe. Automatic scanning was essential to conceive large scale emulsion-based neutrino experiments like CHORUS, DONUT and OPERA. Standard scanning systems have been initially designed to recognize tracks within a limited angular acceptance (θ lesssim 30°) where θ is the track angle with respect to a line perpendicular to the emulsion plane. In this paper we describe the implementation of a novel fast automatic scanning system aimed at extending the track recognition to the full angular range and improving the present scanning speed. Indeed, nuclear emulsions do not have any intrinsic limit to detect particle direction. Such improvement opens new perspectives to use nuclear emulsions in several fields in addition to large scale neutrino experiments, like muon radiography, medical applications and dark matter directional detection.

Improvements to the ShipIR/NTCS adaptive track gate algorithm and 3D flare particle model

NASA Astrophysics Data System (ADS)

Ramaswamy, Srinivasan; Vaitekunas, David A.; Gunter, Willem H.; February, Faith J.

2017-05-01

A key component in any image-based tracking system is the adaptive tracking algorithm used to segment the image into potential targets, rank-and-select the best candidate target, and gate the selected target to further improve tracker performance. Similarly, a key component in any soft-kill response to an incoming guided missile is the flare/chaff decoy used to distract or seduce the seeker homing system away from the naval platform. This paper describes the recent improvements to the naval threat countermeasure simulator (NTCS) of the NATO-standard ship signature model (ShipIR). Efforts to analyse and match the 3D flare particle model against actual IR measurements of the Chemring TALOS IR round resulted in further refinement of the 3D flare particle distribution. The changes in the flare model characteristics were significant enough to require an overhaul to the adaptive track gate (ATG) algorithm in the way it detects the presence of flare decoys and reacquires the target after flare separation. A series of test scenarios are used to demonstrate the impact of the new flare and ATG on IR tactics simulation.

CR-39 track detector calibration for H, He, and C ions from 0.1-0.5 MeV up to 5 MeV for laser-induced nuclear fusion product identification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baccou, C., E-mail: claire.baccou@polytechnique.edu; Yahia, V.; Labaune, C.

Laser-accelerated ion beams can be used in many applications and, especially, to initiate nuclear reactions out of thermal equilibrium. We have experimentally studied aneutronic fusion reactions induced by protons accelerated by the Target Normal Sheath Acceleration mechanism, colliding with a boron target. Such experiments require a rigorous method to identify the reaction products (alpha particles) collected in detectors among a few other ion species such as protons or carbon ions, for example. CR-39 track detectors are widely used because they are mostly sensitive to ions and their efficiency is near 100%. We present a complete calibration of CR-39 track detectormore » for protons, alpha particles, and carbon ions. We give measurements of their track diameters for energy ranging from hundreds of keV to a few MeV and for etching times between 1 and 8 h. We used these results to identify alpha particles in our experiments on proton-boron fusion reactions initiated by laser-accelerated protons. We show that their number clearly increases when the boron fuel is preformed in a plasma state.« less

Imaging samples in silica aerogel using an experimental point spread function.

PubMed

White, Amanda J; Ebel, Denton S

2015-02-01

Light microscopy is a powerful tool that allows for many types of samples to be examined in a rapid, easy, and nondestructive manner. Subsequent image analysis, however, is compromised by distortion of signal by instrument optics. Deconvolution of images prior to analysis allows for the recovery of lost information by procedures that utilize either a theoretically or experimentally calculated point spread function (PSF). Using a laser scanning confocal microscope (LSCM), we have imaged whole impact tracks of comet particles captured in silica aerogel, a low density, porous SiO2 solid, by the NASA Stardust mission. In order to understand the dynamical interactions between the particles and the aerogel, precise grain location and track volume measurement are required. We report a method for measuring an experimental PSF suitable for three-dimensional deconvolution of imaged particles in aerogel. Using fluorescent beads manufactured into Stardust flight-grade aerogel, we have applied a deconvolution technique standard in the biological sciences to confocal images of whole Stardust tracks. The incorporation of an experimentally measured PSF allows for better quantitative measurements of the size and location of single grains in aerogel and more accurate measurements of track morphology.

Controlled method of reducing electrophoretic mobility of various substances

NASA Technical Reports Server (NTRS)

Vanalstine, James M. (Inventor)

1989-01-01

A method of reducing electrophoretic mobility of macromolecules, particles, cells, and the like is provided. The method comprises interacting the particles or cells with a polymer-linked affinity compound composed of: a hydrophilic neutral polymer such as polyethylene glycol, and an affinity component consisting of a hydrophobic compound such as a fatty acid ester, an immunocompound such as an antibody or active fragment thereof or simular macromolecule, or other ligands. The reduction of electrophoretic mobility achieved is directly proportional to the concentration of the polymer-linked affinity compound employed, and the mobility reduction obtainable is up to 100 percent for particular particles and cells. The present invention is advantageous in that analytical electrophoretic separation can not be achieved for macromolecules, particles, and cells whose native surface charge structure had prevented them from being separated by normal electrophoretic means. Depending on the affinity component utilized, separation can be achieved on the basis of specific/irreversible, specific/reversible, semi-specific/reversible, relatively nonspecific/reversible, or relatively nonspecific/irreversible ligand-substance interactions. The present method is also advantageous in that it can be used in a variety of standard laboratory electrophoresis equipment.

Primary cosmic ray particles with z 35 (VVH particles). [very heavy particle detection by high altitude balloons

NASA Technical Reports Server (NTRS)

Blanford, G. E., Jr.; Friedlander, M. W.; Hoppe, M.; Klarmann, J.; Walker, R. M.; Wefel, J. P.

1972-01-01

Large areas of nuclear emulsions and plastic detectors were exposed to the primary cosmic radiation during high altitude balloon flights. From the analysis of 141 particle tracks recorded during a total exposure of 1.3 x 10 to the 7th power sq m ster.sec., a charge spectrum of the VVH particles has been derived.

Defining the Biological Effectiveness of Components of High-LET Track Structure.

PubMed

Sridharan, Deepa M; Chappell, Lori J; Whalen, Mary K; Cucinotta, Francis A; Pluth, Janice M

2015-07-01

During space travel, astronauts are exposed to a wide array of high-linear energy transfer (LET) particles, with differing energies and resulting biological effects. Risk assessment of these exposures carries a large uncertainty predominantly due to the unique track structure of the particle's energy deposition. The complex damage elicited by high charge and energy (HZE) particles results from both lesions along the track core and from energetic electrons, δ rays, generated as a consequence of particle traversal. To better define how cells respond to this complex radiation exposure, a normal hTERT immortalized skin fibroblast cell line was exposed to a defined panel of particles carefully chosen to tease out track structure effects. Phosphorylation kinetics for several key double-strand break (DSB) response proteins (γ-H2AX, pATF2 and pSMC1) were defined after exposure to ten different high-LET radiation qualities and one low-LET radiation (X ray), at two doses (0.5-2 Gy) and time points (2 and 24 h). The results reveal that the lower energy particles (Fe 300, Si 93 and Ti 300 MeV/u), with a narrower track width and higher number and intensity of δ rays, cause the highest degree of persistent damage response. The persistent γ-H2AX signal at lower energies suggests that damage from these exposures are more difficult to resolve, likely due to the greater complexity of the associated DNA lesions. However, different kinetics were observed for the solely ATM-mediated phosphorylations (pATF2 and pSMC1), revealing a shallow induction at early times and a higher level of residual phosphorylation compared to γ-H2AX. The differing phospho-protein profiles exhibited, compared to γ-H2AX, suggests additional functions for these proteins within the cell. The strong correspondence between the predicted curves for energy deposition per nucleosome for each ion/energy combination and the persistent levels of γ-H2AX indicates that the nature of energy distribution defines residual levels of γ-H2AX, an indicator of unrepaired DSBs. Our results suggest that decreasing the energy of a particle results in more complex damage that may increase genomic instability and increase the risk of carcinogenesis.

Back-tracking of primary particle trajectories for muons detected at the Earth surface

NASA Astrophysics Data System (ADS)

Shutenko, V. V.

2017-01-01

Investigations of cosmic rays on the surface of the Earth allow to derive information of applied character on the conditions of the interplanetary magnetic field and of the geomagnetic field. For this purpose, it is necessary to collate trajectories of particles detected in the ground-based detector to trajectories of primary cosmic rays in the heliosphere. This problem is solved by means of various back-tracking methods. In this work, one of such methods is presented.

The Remote Detection of Alpha-Radioactive Nucleus Decay

NASA Astrophysics Data System (ADS)

Gurkovskiy, Boris; Miroshnichenko, Vladimir; Onishchenko, Evgeny; Simakov, Andrey; Streil, Thomas

Results of the new device design for the alpha-radiation remote detection are presented. Negative ions from the alpha particle tracks are detected by the discharge wire counter opened to air. Ion clusters being transferred from the particle tracks to the detector volume by an air flux. The detector works in a counting mode that provides sharp selectivity and accuracy of measurements. The basic parameters of the device are: detecting distance -0.5 m; measurement time -30 s; the square sensitivity -0.05 Bq/cm2.

Particle-tracking analysis of contributing areas of public-supply wells in simple and complex flow systems, Cape Cod, Massachusetts

USGS Publications Warehouse

Barlow, Paul M.

1997-01-01

Steady-state, two- and three-dimensional, ground-water-flow models coupled with particle tracking were evaluated to determine their effectiveness in delineating contributing areas of wells pumping from stratified-drift aquifers of Cape Cod, Massachusetts. Several contributing areas delineated by use of the three-dimensional models do not conform to simple ellipsoidal shapes that are typically delineated by use of two-dimensional analytical and numerical modeling techniques and included discontinuous areas of the water table.

Impact of x-ray dose on track formation and data analysis for CR-39-based proton diagnostics

NASA Astrophysics Data System (ADS)

Rinderknecht, H. G.; Rojas-Herrera, J.; Zylstra, A. B.; Frenje, J. A.; Gatu Johnson, M.; Sio, H.; Sinenian, N.; Rosenberg, M. J.; Li, C. K.; Séguin, F. H.; Petrasso, R. D.; Filkins, T.; Steidle, Jeffrey A.; Steidle, Jessica A.; Traynor, N.; Freeman, C.

2015-12-01

The nuclear track detector CR-39 is used extensively for charged particle diagnosis, in particular proton spectroscopy, at inertial confinement fusion facilities. These detectors can absorb x-ray doses from the experiments in the order of 1-100 Gy, the effects of which are not accounted for in the previous detector calibrations. X-ray dose absorbed in the CR-39 has previously been shown to affect the track size of alpha particles in the detector, primarily due to a measured reduction in the material bulk etch rate [Rojas-Herrera et al., Rev. Sci. Instrum. 86, 033501 (2015)]. Similar to the previous findings for alpha particles, protons with energies in the range 0.5-9.1 MeV are shown to produce tracks that are systematically smaller as a function of the absorbed x-ray dose in the CR-39. The reduction of track size due to x-ray dose is found to diminish with time between exposure and etching if the CR-39 is stored at ambient temperature, and complete recovery is observed after two weeks. The impact of this effect on the analysis of data from existing CR-39-based proton diagnostics on OMEGA and the National Ignition Facility is evaluated and best practices are proposed for cases in which the effect of x rays is significant.

Impact of x-ray dose on track formation and data analysis for CR-39-based proton diagnostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rinderknecht, H. G.; Rojas-Herrera, J.; Zylstra, A. B.

The nuclear track detector CR-39 is used extensively for charged particle diagnosis, in particular proton spectroscopy, at inertial confinement fusion facilities. These detectors can absorb x-ray doses from the experiments in the order of 1–100 Gy, the effects of which are not accounted for in the previous detector calibrations. X-ray dose absorbed in the CR-39 has previously been shown to affect the track size of alpha particles in the detector, primarily due to a measured reduction in the material bulk etch rate [Rojas-Herrera et al., Rev. Sci. Instrum. 86, 033501 (2015)]. Similar to the previous findings for alpha particles, protonsmore » with energies in the range 0.5–9.1 MeV are shown to produce tracks that are systematically smaller as a function of the absorbed x-ray dose in the CR-39. The reduction of track size due to x-ray dose is found to diminish with time between exposure and etching if the CR-39 is stored at ambient temperature, and complete recovery is observed after two weeks. Furthermore, the impact of this effect on the analysis of data from existing CR-39-based proton diagnostics on OMEGA and the National Ignition Facility is evaluated and best practices are proposed for cases in which the effect of x rays is significant.« less

Impact of x-ray dose on track formation and data analysis for CR-39-based proton diagnostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rinderknecht, H. G., E-mail: rinderknecht1@llnl.gov; Rojas-Herrera, J.; Zylstra, A. B.

The nuclear track detector CR-39 is used extensively for charged particle diagnosis, in particular proton spectroscopy, at inertial confinement fusion facilities. These detectors can absorb x-ray doses from the experiments in the order of 1–100 Gy, the effects of which are not accounted for in the previous detector calibrations. X-ray dose absorbed in the CR-39 has previously been shown to affect the track size of alpha particles in the detector, primarily due to a measured reduction in the material bulk etch rate [Rojas-Herrera et al., Rev. Sci. Instrum. 86, 033501 (2015)]. Similar to the previous findings for alpha particles, protonsmore » with energies in the range 0.5–9.1 MeV are shown to produce tracks that are systematically smaller as a function of the absorbed x-ray dose in the CR-39. The reduction of track size due to x-ray dose is found to diminish with time between exposure and etching if the CR-39 is stored at ambient temperature, and complete recovery is observed after two weeks. The impact of this effect on the analysis of data from existing CR-39-based proton diagnostics on OMEGA and the National Ignition Facility is evaluated and best practices are proposed for cases in which the effect of x rays is significant.« less

Impact of x-ray dose on track formation and data analysis for CR-39-based proton diagnostics

DOE PAGES

Rinderknecht, H. G.; Rojas-Herrera, J.; Zylstra, A. B.; ...

2015-12-23

The nuclear track detector CR-39 is used extensively for charged particle diagnosis, in particular proton spectroscopy, at inertial confinement fusion facilities. These detectors can absorb x-ray doses from the experiments in the order of 1–100 Gy, the effects of which are not accounted for in the previous detector calibrations. X-ray dose absorbed in the CR-39 has previously been shown to affect the track size of alpha particles in the detector, primarily due to a measured reduction in the material bulk etch rate [Rojas-Herrera et al., Rev. Sci. Instrum. 86, 033501 (2015)]. Similar to the previous findings for alpha particles, protonsmore » with energies in the range 0.5–9.1 MeV are shown to produce tracks that are systematically smaller as a function of the absorbed x-ray dose in the CR-39. The reduction of track size due to x-ray dose is found to diminish with time between exposure and etching if the CR-39 is stored at ambient temperature, and complete recovery is observed after two weeks. Furthermore, the impact of this effect on the analysis of data from existing CR-39-based proton diagnostics on OMEGA and the National Ignition Facility is evaluated and best practices are proposed for cases in which the effect of x rays is significant.« less

3D imaging of particle tracks in Solid State Nuclear Track Detectors

NASA Astrophysics Data System (ADS)

Wertheim, D.; Gillmore, G.; Brown, L.; Petford, N.

2009-04-01

Inhalation of radon gas (222Rn) and associated ionizing decay products is known to cause lung cancer in human. In the U.K., it has been suggested that 3 to 5 % of total lung cancer deaths can be linked to elevated radon concentrations in the home and/or workplace. Radon monitoring in buildings is therefore routinely undertaken in areas of known risk. Indeed, some organisations such as the Radon Council in the UK and the Environmental Protection Agency in the USA, advocate a ‘to test is best' policy. Radon gas occurs naturally, emanating from the decay of 238U in rock and soils. Its concentration can be measured using CR?39 plastic detectors which conventionally are assessed by 2D image analysis of the surface; however there can be some variation in outcomes / readings even in closely spaced detectors. A number of radon measurement methods are currently in use (for examples, activated carbon and electrets) but the most widely used are CR?39 solid state nuclear track?etch detectors (SSNTDs). In this technique, heavily ionizing alpha particles leave tracks in the form of radiation damage (via interaction between alpha particles and the atoms making up the CR?39 polymer). 3D imaging of the tracks has the potential to provide information relating to angle and energy of alpha particles but this could be time consuming. Here we describe a new method for rapid high resolution 3D imaging of SSNTDs. A ‘LEXT' OLS3100 confocal laser scanning microscope was used in confocal mode to successfully obtain 3D image data on four CR?39 plastic detectors. 3D visualisation and image analysis enabled characterisation of track features. This method may provide a means of rapid and detailed 3D analysis of SSNTDs. Keywords: Radon; SSNTDs; confocal laser scanning microscope; 3D imaging; LEXT

Airflow, transport and regional deposition of aerosol particles during chronic bronchitis of human central airways.

PubMed

Farkhadnia, Fouad; Gorji, Tahereh B; Gorji-Bandpy, Mofid

2016-03-01

In the present study, the effects of airway blockage in chronic bronchitis disease on the flow patterns and transport/deposition of micro-particles in a human symmetric triple bifurcation lung airway model, i.e., Weibel's generations G3-G6 was investigated. A computational fluid and particle dynamics model was implemented, validated and applied in order to evaluate the airflow and particle transport/deposition in central airways. Three breathing patterns, i.e., resting, light activity and moderate exercise, were considered. Using Lagrangian approach for particle tracking and random particle injection, an unsteady particle tracking method was performed to simulate the transport and deposition of micron-sized aerosol particles in human central airways. Assuming laminar, quasi-steady, three-dimensional air flow and spherical non-interacting particles in sequentially bifurcating rigid airways, airflow patterns and particle transport/deposition in healthy and chronic bronchitis (CB) affected airways were evaluated and compared. Comparison of deposition efficiency (DE) of aerosols in healthy and occluded airways showed that at the same flow rates DE values are typically larger in occluded airways. While in healthy airways, particles deposit mainly around the carinal ridges and flow dividers--due to direct inertial impaction, in CB affected airways they deposit mainly on the tubular surfaces of blocked airways because of gravitational sedimentation.

Cellular track model of biological damage to mammalian cell cultures from galactic cosmic rays

NASA Technical Reports Server (NTRS)

Cucinotta, Francis A.; Katz, Robert; Wilson, John W.; Townsend, Lawrence W.; Nealy, John E.; Shinn, Judy L.

1991-01-01

The assessment of biological damage from the galactic cosmic rays (GCR) is a current interest for exploratory class space missions where the highly ionizing, high-energy, high-charge ions (HZE) particles are the major concern. The relative biological effectiveness (RBE) values determined by ground-based experiments with HZE particles are well described by a parametric track theory of cell inactivation. Using the track model and a deterministic GCR transport code, the biological damage to mammalian cell cultures is considered for 1 year in free space at solar minimum for typical spacecraft shielding. Included are the effects of projectile and target fragmentation. The RBE values for the GCR spectrum which are fluence-dependent in the track model are found to be more severe than the quality factors identified by the International Commission on Radiological Protection publication 26 and seem to obey a simple scaling law with the duration period in free space.

Tracking single mRNA molecules in live cells

NASA Astrophysics Data System (ADS)

Moon, Hyungseok C.; Lee, Byung Hun; Lim, Kiseong; Son, Jae Seok; Song, Minho S.; Park, Hye Yoon

2016-06-01

mRNAs inside cells interact with numerous RNA-binding proteins, microRNAs, and ribosomes that together compose a highly heterogeneous population of messenger ribonucleoprotein (mRNP) particles. Perhaps one of the best ways to investigate the complex regulation of mRNA is to observe individual molecules. Single molecule imaging allows the collection of quantitative and statistical data on subpopulations and transient states that are otherwise obscured by ensemble averaging. In addition, single particle tracking reveals the sequence of events that occur in the formation and remodeling of mRNPs in real time. Here, we review the current state-of-the-art techniques in tagging, delivery, and imaging to track single mRNAs in live cells. We also discuss how these techniques are applied to extract dynamic information on the transcription, transport, localization, and translation of mRNAs. These studies demonstrate how single molecule tracking is transforming the understanding of mRNA regulation in live cells.

Analysis system of submicron particle tracks in the fine-grained nuclear emulsion by a combination of hard x-ray and optical microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naka, T., E-mail: naka@flab.phys.nagoya-u.ac.jp; Institute for Advanced Research, Nagoya University, Aichi 464-8602; Asada, T.

Analyses of nuclear emulsion detectors that can detect and identify charged particles or radiation as tracks have typically utilized optical microscope systems because the targets have lengths from several μm to more than 1000 μm. For recent new nuclear emulsion detectors that can detect tracks of submicron length or less, the current readout systems are insufficient due to their poor resolution. In this study, we developed a new system and method using an optical microscope system for rough candidate selection and the hard X-ray microscope system at SPring-8 for high-precision analysis with a resolution of better than 70 nm resolution.more » Furthermore, we demonstrated the analysis of submicron-length tracks with a matching efficiency of more than 99% and position accuracy of better than 5 μm. This system is now running semi-automatically.« less

Fast emulation of track reconstruction in the CMS simulation

NASA Astrophysics Data System (ADS)

Komm, Matthias; CMS Collaboration

2017-10-01

Simulated samples of various physics processes are a key ingredient within analyses to unlock the physics behind LHC collision data. Samples with more and more statistics are required to keep up with the increasing amounts of recorded data. During sample generation, significant computing time is spent on the reconstruction of charged particle tracks from energy deposits which additionally scales with the pileup conditions. In CMS, the FastSimulation package is developed for providing a fast alternative to the standard simulation and reconstruction workflow. It employs various techniques to emulate track reconstruction effects in particle collision events. Several analysis groups in CMS are utilizing the package, in particular those requiring many samples to scan the parameter space of physics models (e.g. SUSY) or for the purpose of estimating systematic uncertainties. The strategies for and recent developments in this emulation are presented, including a novel, flexible implementation of tracking emulation while retaining a sufficient, tuneable accuracy.

Creation of heterogeneous materials on the basis of B4C and Ni powders by the method of cold spraying with subsequent layer-by-layer laser treatment

NASA Astrophysics Data System (ADS)

Fomin, V. M.; Golyshev, A. A.; Kosarev, V. F.; Malikov, A. G.; Orishich, A. M.; Ryashin, N. S.; Filippov, A. A.; Shikalov, V. S.

2017-09-01

A method is proposed for creating principally new functionally graded heterogeneous materials on the basis of B4C ceramic powders with different mass fractions in the original mixture and plastic metallic additive of Ni by a combined method of cold spraying with subsequent layer-by-layer laser treatment. Mechanical properties of the resultant tracks are examined. It is shown that the track microhardness increases with increasing B4C concentration in the original mixture. The track structure is found to depend on the size of ceramic particles in the interval from 3 to 75 μm. Reduction of the B4C particle size (approximately by a factor of 2-3) inside the track owing to fragmentation under the action of the laser beam is observed for the first time.

On the dynamics of jellyfish locomotion via 3D particle tracking velocimetry

NASA Astrophysics Data System (ADS)

Piper, Matthew; Kim, Jin-Tae; Chamorro, Leonardo P.

2016-11-01

The dynamics of jellyfish (Aurelia aurita) locomotion is experimentally studied via 3D particle tracking velocimetry. 3D locations of the bell tip are tracked over 1.5 cycles to describe the jellyfish path. Multiple positions of the jellyfish bell margin are initially tracked in 2D from four independent planes and individually projected in 3D based on the jellyfish path and geometrical properties of the setup. A cubic spline interpolation and the exponentially weighted moving average are used to estimate derived quantities, including velocity and acceleration of the jellyfish locomotion. We will discuss distinctive features of the jellyfish 3D motion at various swimming phases, and will provide insight on the 3D contraction and relaxation in terms of the locomotion, the steadiness of the bell margin eccentricity, and local Reynolds number based on the instantaneous mean diameter of the bell.

Numerical Experiments on Advective Transport in Large Three-Dimensional Discrete Fracture Networks

NASA Astrophysics Data System (ADS)

Makedonska, N.; Painter, S. L.; Karra, S.; Gable, C. W.

2013-12-01

Modeling of flow and solute transport in discrete fracture networks is an important approach for understanding the migration of contaminants in impermeable hard rocks such as granite, where fractures provide dominant flow and transport pathways. The discrete fracture network (DFN) model attempts to mimic discrete pathways for fluid flow through a fractured low-permeable rock mass, and may be combined with particle tracking simulations to address solute transport. However, experience has shown that it is challenging to obtain accurate transport results in three-dimensional DFNs because of the high computational burden and difficulty in constructing a high-quality unstructured computational mesh on simulated fractures. An integrated DFN meshing [1], flow, and particle tracking [2] simulation capability that enables accurate flow and particle tracking simulation on large DFNs has recently been developed. The new capability has been used in numerical experiments on advective transport in large DFNs with tens of thousands of fractures and millions of computational cells. The modeling procedure starts from the fracture network generation using a stochastic model derived from site data. A high-quality computational mesh is then generated [1]. Flow is then solved using the highly parallel PFLOTRAN [3] code. PFLOTRAN uses the finite volume approach, which is locally mass conserving and thus eliminates mass balance problems during particle tracking. The flow solver provides the scalar fluxes on each control volume face. From the obtained fluxes the Darcy velocity is reconstructed for each node in the network [4]. Velocities can then be continuously interpolated to any point in the domain of interest, thus enabling random walk particle tracking. In order to describe the flow field on fractures intersections, the control volume cells on intersections are split into four planar polygons, where each polygon corresponds to a piece of a fracture near the intersection line. Thus, computational nodes lying on fracture intersections have four associated velocities, one on each side of the intersection in each fracture plane [2]. This information is used to route particles arriving at the fracture intersection to the appropriate downstream fracture segment. Verified for small DFNs, the new simulation capability allows accurate particle tracking on more realistic representations of fractured rock sites. In the current work we focus on travel time statistics and spatial dispersion and show numerical results in DFNs of different sizes, fracture densities, and transmissivity distributions. [1] Hyman J.D., Gable C.W., Painter S.L., Automated meshing of stochastically generated discrete fracture networks, Abstract H33G-1403, 2011 AGU, San Francisco, CA, 5-9 Dec. [2] N. Makedonska, S. L. Painter, T.-L. Hsieh, Q.M. Bui, and C. W. Gable., Development and verification of a new particle tracking capability for modeling radionuclide transport in discrete fracture networks, Abstract, 2013 IHLRWM, Albuquerque, NM, Apr. 28 - May 3. [3] Lichtner, P.C., Hammond, G.E., Bisht, G., Karra, S., Mills, R.T., and Kumar, J. (2013) PFLOTRAN User's Manual: A Massively Parallel Reactive Flow Code. [4] Painter S.L., Gable C.W., Kelkar S., Pathline tracing on fully unstructured control-volume grids, Computational Geosciences, 16 (4), 2012, 1125-1134.

Magnesium activation of GTP hydrolysis or incubation in S-adenosyl-l-methionine reverses iron-56-particle-induced decrements in oxotremorine enhancement of K+-evoked striatal release of dopamine.

PubMed

Joseph, J A; Shukitt-Hale, B; McEwen, J; Rabin, B

1999-12-01

Previous research has determined that the deficits in motor behavior seen in aged animals irradiated with (56)Fe particles involved alterations in muscarinic receptor sensitivity. In the present experiments, we determined whether increasing either membrane fluidity by exposure of striatal slices from irradiated ((56)Fe particles) animals to S-adenosyl-l-methionine (SAM) or GTP hydrolysis with Mg(2+) would reverse this (56)Fe-particle-induced loss of muscarinic receptor sensitivity, as has been observed in aged animals. Results indicated that, while increasing Mg(2+) concentrations in the incubation medium was effective in reducing the radiation effects, SAM was able to effect some reversal of the radiation effects only at the lower concentration (200 microM). These results suggest that similar mechanisms may be involved in the deficits in signal transduction seen after (56)Fe-particle irradiation to those seen in aging, and that these may include changes in the membrane structure or composition that could alter subsequent responsiveness of transduction pathways. The results further suggest that, as has been reported previously, (56)Fe-particle irradiation may accelerate brain aging, and that since these HZE particles contribute at least 1% of the dose that astronauts would receive from cosmic rays, long-term exposure on extended space flights (e.g. to Mars) may produce similar deficits that could have immediate or delayed effects on behavior.

The Hadron Blind Ring Imaging Cherenkov Detector

NASA Astrophysics Data System (ADS)

Blatnik, Marie; Zajac, Stephanie; Hemmick, Tom

2013-10-01

Heavy Ion Collisions in the Relativistic Heavy Ion Collider (RHIC) at Brookhaven Lab have hinted at the existence of a new form of matter at high gluon density, the Color Glass Condensate. High energy electron scattering off of nuclei, focusing on the low-x components of the nuclear wave function, will definitively measure this state of matter. However, when a nucleus contributes a low x parton, the reaction products are highly focused in the electron-going direction and have large momentum in the lab system. High-momentum particle identification is particularly challenging. A particle is identifiable by its mass, but tracking algorithms only yield a particle's momentum based on its track's curvature. The particle's velocity is needed to identify the particle. A ring-imaging Cerenkov detector is being developed for the forward angle particle identification from the technological advancements of PHENIX's Hadron-Blind Detector (HBD), which uses Gas Electron Multipliers (GEMs) and pixelated pad planes to detect Cerenkov photons. The new HBD will focus the Cerenkov photons into a ring to determine the parent particle's velocity. Results from the pad plane simulations, construction tests, and test beam run will be presented.

Effects of translation-rotation coupling on the displacement probability distribution functions of boomerang colloidal particles

NASA Astrophysics Data System (ADS)

Chakrabarty, Ayan; Wang, Feng; Sun, Kai; Wei, Qi-Huo

Prior studies have shown that low symmetry particles such as micro-boomerangs exhibit behaviour of Brownian motion rather different from that of high symmetry particles because convenient tracking points (TPs) are usually inconsistent with the center of hydrodynamic stress (CoH) where the translational and rotational motions are decoupled. In this paper we study the effects of the translation-rotation coupling on the displacement probability distribution functions (PDFs) of the boomerang colloid particles with symmetric arms. By tracking the motions of different points on the particle symmetry axis, we show that as the distance between the TP and the CoH is increased, the effects of translation-rotation coupling becomes pronounced, making the short-time 2D PDF for fixed initial orientation to change from elliptical to crescent shape and the angle averaged PDFs from ellipsoidal-particle-like PDF to a shape with a Gaussian top and long displacement tails. We also observed that at long times the PDFs revert to Gaussian. This crescent shape of 2D PDF provides a clear physical picture of the non-zero mean displacements observed in boomerangs particles.

High serum levels of pregenomic RNA reflect frequently failing reverse transcription in hepatitis B virus particles.

PubMed

Prakash, Kasthuri; Rydell, Gustaf E; Larsson, Simon B; Andersson, Maria; Norkrans, Gunnar; Norder, Heléne; Lindh, Magnus

2018-05-15

Hepatocytes infected by hepatitis B virus (HBV) produce different HBV RNA species, including pregenomic RNA (pgRNA), which is reverse transcribed during replication. Particles containing HBV RNA are present in serum of infected individuals, and quantification of this HBV RNA could be clinically useful. In a retrospective study of 95 patients with chronic HBV infection, we characterised HBV RNA in serum in terms of concentration, particle association and sequence. HBV RNA was detected by real-time PCR at levels almost as high as HBV DNA. The HBV RNA was protected from RNase and it was found in particles of similar density as particles containing HBV DNA after fractionation on a Nycodenz gradient. Sequencing the epsilon region of the RNA did not reveal mutations that would preclude its binding to the viral polymerase before encapsidation. Specific quantification of precore RNA and pgRNA by digital PCR showed almost seven times lower ratio of precore RNA/pgRNA in serum than in liver tissue, which corresponds to poorer encapsidation of this RNA as compared with pgRNA. The serum ratio between HBV DNA and HBV RNA was higher in genotype D as compared with other genotypes. The results suggest that HBV RNA in serum is present in viral particles with failing reverse transcription activity, which are produced at almost as high rates as viral particles containing DNA. The results encourage further studies of the mechanisms by which these particles are produced, the impact of genotype, and the potential clinical utility of quantifying HBV RNA in serum.

Reversibly immobilized biological materials in monolayer films on electrodes

DOEpatents

Weaver, P.F.; Frank, A.J.

1993-05-04

Methods and techniques are described for reversibly binding charged biological particles in a fluid medium to an electrode surface. The methods are useful in a variety of applications. The biological materials may include microbes, proteins, and viruses. The electrode surface may consist of reversibly electroactive materials such as polyvinylferrocene, silicon-linked ferrocene or quinone.

Reversibly immobilized biological materials in monolayer films on electrodes

DOEpatents

Weaver, Paul F.; Frank, Arthur J.

1993-01-01

Methods and techniques are described for reversibly binding charged biological particles in a fluid medium to an electrode surface. The methods are useful in a variety of applications. The biological materials may include microbes, proteins, and viruses. The electrode surface may consist of reversibly electroactive materials such as polyvinylferrocene, silicon-linked ferrocene or quinone.

Review of the Microdosimetric Studies for High-Energy Charged Particle Beams Using a Tissue-Equivalent Proportional Counter

NASA Astrophysics Data System (ADS)

Tsuda, Shuichi; Sato, Tatsuhiko; Ogawa, Tatsuhiko; Sasaki, Shinichi

Lineal energy (y) distributions were measured for various types of charged particles such as protons and iron, with kinetic energies of up to 500 MeV/u, via the use of a wall-less tissue-equivalent proportional counter (TEPC). Radial dependencies of y distributions were also experimentally evaluated to investigate the track structures of protons, carbon, and iron beams. This paper reviews a series of measured data using the aforementioned TEPC as well as assesses the systematic verification of a microdosimetric calculation model of a y distribution incorporated into the particle and heavy ion transport code system (PHITS) and associated track structure models.

Segmentation of Nerve Bundles and Ganglia in Spine MRI Using Particle Filters

PubMed Central

Dalca, Adrian; Danagoulian, Giovanna; Kikinis, Ron; Schmidt, Ehud; Golland, Polina

2011-01-01

Automatic segmentation of spinal nerve bundles that originate within the dural sac and exit the spinal canal is important for diagnosis and surgical planning. The variability in intensity, contrast, shape and direction of nerves seen in high resolution myelographic MR images makes segmentation a challenging task. In this paper, we present an automatic tracking method for nerve segmentation based on particle filters. We develop a novel approach to particle representation and dynamics, based on Bézier splines. Moreover, we introduce a robust image likelihood model that enables delineation of nerve bundles and ganglia from the surrounding anatomical structures. We demonstrate accurate and fast nerve tracking and compare it to expert manual segmentation. PMID:22003741

Objective comparison of particle tracking methods

PubMed Central

Chenouard, Nicolas; Smal, Ihor; de Chaumont, Fabrice; Maška, Martin; Sbalzarini, Ivo F.; Gong, Yuanhao; Cardinale, Janick; Carthel, Craig; Coraluppi, Stefano; Winter, Mark; Cohen, Andrew R.; Godinez, William J.; Rohr, Karl; Kalaidzidis, Yannis; Liang, Liang; Duncan, James; Shen, Hongying; Xu, Yingke; Magnusson, Klas E. G.; Jaldén, Joakim; Blau, Helen M.; Paul-Gilloteaux, Perrine; Roudot, Philippe; Kervrann, Charles; Waharte, François; Tinevez, Jean-Yves; Shorte, Spencer L.; Willemse, Joost; Celler, Katherine; van Wezel, Gilles P.; Dan, Han-Wei; Tsai, Yuh-Show; de Solórzano, Carlos Ortiz; Olivo-Marin, Jean-Christophe; Meijering, Erik

2014-01-01

Particle tracking is of key importance for quantitative analysis of intracellular dynamic processes from time-lapse microscopy image data. Since manually detecting and following large numbers of individual particles is not feasible, automated computational methods have been developed for these tasks by many groups. Aiming to perform an objective comparison of methods, we gathered the community and organized, for the first time, an open competition, in which participating teams applied their own methods independently to a commonly defined data set including diverse scenarios. Performance was assessed using commonly defined measures. Although no single method performed best across all scenarios, the results revealed clear differences between the various approaches, leading to important practical conclusions for users and developers. PMID:24441936

Segmentation of nerve bundles and ganglia in spine MRI using particle filters.

PubMed

Dalca, Adrian; Danagoulian, Giovanna; Kikinis, Ron; Schmidt, Ehud; Golland, Polina

2011-01-01

Automatic segmentation of spinal nerve bundles that originate within the dural sac and exit the spinal canal is important for diagnosis and surgical planning. The variability in intensity, contrast, shape and direction of nerves seen in high resolution myelographic MR images makes segmentation a challenging task. In this paper, we present an automatic tracking method for nerve segmentation based on particle filters. We develop a novel approach to particle representation and dynamics, based on Bézier splines. Moreover, we introduce a robust image likelihood model that enables delineation of nerve bundles and ganglia from the surrounding anatomical structures. We demonstrate accurate and fast nerve tracking and compare it to expert manual segmentation.

Coating and Impregnation of Carbon-Carbon Composites with Ceramics by Electrophoretic Deposition

DTIC Science & Technology

1989-04-01

electroosmotic effect 33 4.1.4 Electrophoretic impregnation of a porous substrate with ceramic particles 53 4.1.5 Morphology of induced Si02 60 4.1.6...particles acquire the charge spontaneously when mixed with the solvent. Further, this charge may be reversed upon addition of ionic compounds. According...spontaneously when mixed with the solvent. Further this charge may be reversed upon addition of ions. 2.2 ELECTHOPHORESIS IN POROUS STRUCTURES i In

Micromagnetics and second-order reversal-curves as a route to understanding FORC diagrams of nanoparticles

NASA Astrophysics Data System (ADS)

Winklhofer, M.

2007-05-01

First-order-reversal curve (FORC) diagrams have proven useful in characterizing fine magnetic particle systems in terms of microscopic switching field distributions, characteristic interaction strengths and mean-field effects. Despite the profusion of measured FORC data, we still lack a simple, generally valid recipe for the quantitative analysis of FORC diagrams, the reason being that most samples do not act like classical linear Preisach systems, giving rise to reversible magnetization changes that tend to blur contributions from irreversible switching events. A good example illustrating the confounding influence of reversible contributions are FORC diagrams for particle systems in which vortex configurations occur as remanent states. For non-interacting Fe nanodots with well-defined grain sizes around the zero-field SD/PSD transition and random easy-axis orientation, we will show how a combination of micromagnetic modelling and second-order- reversal-curves can be used to disentangle reversible and irreversible contributions to the FORC diagram. It will also be shown that remanence-based Preisach diagrams do not fully capture the irreversible parts.

TH-A-19A-04: Latent Uncertainties and Performance of a GPU-Implemented Pre-Calculated Track Monte Carlo Method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renaud, M; Seuntjens, J; Roberge, D

Purpose: Assessing the performance and uncertainty of a pre-calculated Monte Carlo (PMC) algorithm for proton and electron transport running on graphics processing units (GPU). While PMC methods have been described in the past, an explicit quantification of the latent uncertainty arising from recycling a limited number of tracks in the pre-generated track bank is missing from the literature. With a proper uncertainty analysis, an optimal pre-generated track bank size can be selected for a desired dose calculation uncertainty. Methods: Particle tracks were pre-generated for electrons and protons using EGSnrc and GEANT4, respectively. The PMC algorithm for track transport was implementedmore » on the CUDA programming framework. GPU-PMC dose distributions were compared to benchmark dose distributions simulated using general-purpose MC codes in the same conditions. A latent uncertainty analysis was performed by comparing GPUPMC dose values to a “ground truth” benchmark while varying the track bank size and primary particle histories. Results: GPU-PMC dose distributions and benchmark doses were within 1% of each other in voxels with dose greater than 50% of Dmax. In proton calculations, a submillimeter distance-to-agreement error was observed at the Bragg Peak. Latent uncertainty followed a Poisson distribution with the number of tracks per energy (TPE) and a track bank of 20,000 TPE produced a latent uncertainty of approximately 1%. Efficiency analysis showed a 937× and 508× gain over a single processor core running DOSXYZnrc for 16 MeV electrons in water and bone, respectively. Conclusion: The GPU-PMC method can calculate dose distributions for electrons and protons to a statistical uncertainty below 1%. The track bank size necessary to achieve an optimal efficiency can be tuned based on the desired uncertainty. Coupled with a model to calculate dose contributions from uncharged particles, GPU-PMC is a candidate for inverse planning of modulated electron radiotherapy and scanned proton beams. This work was supported in part by FRSQ-MSSS (Grant No. 22090), NSERC RG (Grant No. 432290) and CIHR MOP (Grant No. MOP-211360)« less

Severe Weather Guide - Mediterranean Ports. 7. Marseille

DTIC Science & Technology

1988-03-01

the afternoon. Upper—level westerlies and the associated storm track is moved northward during summer, so extratropical cyclones and associated...autumn as the extratropical storm track moves southward. Precipitation amount is the highest of the year, with an average of 3 inches (76 mm) for the...18 SUBJECT TERMS (Continue on reverse if necessary and identify by block number) Storm haven Mediterranean meteorology Marseille port

Modulating Retro-Reflectors for Space, Tracking, Acquisition and Ranging using Multiple Quantum Well Technology (Preprint)

DTIC Science & Technology

2002-01-01

feedback signals were derived from the motion of the platform rather than directly measured, though an actual spacecraft would likely utilize... large position error spikes due to target motion reversal. Of course, these tracking errors are highly dependent on the feedback gains chosen for the...Key Words: MQW Retromodulators, Modulating Retroreflector(s),Inter- spacecraft communications and navigation, space control

Adaptation of multidimensional group particle tracking and particle wall-boundary condition model to the FDNS code

NASA Technical Reports Server (NTRS)

Chen, Y. S.; Farmer, R. C.

1992-01-01

A particulate two-phase flow CFD model was developed based on the FDNS code which is a pressure based predictor plus multi-corrector Navier-Stokes flow solver. Turbulence models with compressibility correction and the wall function models were employed as submodels. A finite-rate chemistry model was used for reacting flow simulation. For particulate two-phase flow simulations, a Eulerian-Lagrangian solution method using an efficient implicit particle trajectory integration scheme was developed in this study. Effects of particle-gas reaction and particle size change to agglomeration or fragmentation were not considered in this investigation. At the onset of the present study, a two-dimensional version of FDNS which had been modified to treat Lagrangian tracking of particles (FDNS-2DEL) had already been written and was operational. The FDNS-2DEL code was too slow for practical use, mainly because it had not been written in a form amenable to vectorization on the Cray, nor was the full three-dimensional form of FDNS utilized. The specific objective of this study was to reorder to calculations into long single arrays for automatic vectorization on the Cray and to implement the full three-dimensional version of FDNS to produce the FDNS-3DEL code. Since the FDNS-2DEL code was slow, a very limited number of test cases had been run with it. This study was also intended to increase the number of cases simulated to verify and improve, as necessary, the particle tracking methodology coded in FDNS.

Track reconstruction in the inhomogeneous magnetic field for Vertex Detector of NA61/SHINE experiment at CERN SPS

NASA Astrophysics Data System (ADS)

Merzlaya, Anastasia; NA61/SHINE Collaboration

2017-01-01

The heavy-ion programme of the NA61/SHINE experiment at CERN SPS is expanding to allow precise measurements of exotic particles with lifetime few hundred microns. A Vertex Detector for open charm measurements at the SPS is being constructed by the NA61/SHINE Collaboration to meet the challenges of high spatial resolution of secondary vertices and efficiency of track registration. This task is solved by the application of the coordinate sensitive CMOS Monolithic Active Pixel Sensors with extremely low material budget in the new Vertex Detector. A small-acceptance version of the Vertex Detector is being tested this year, later it will be expanded to a large-acceptance version. Simulation studies will be presented. A method of track reconstruction in the inhomogeneous magnetic field for the Vertex Detector was developed and implemented. Numerical calculations show the possibility of high precision measurements in heavy ion collisions of strange and multi strange particles, as well as heavy flavours, like charmed particles.

Combining Particle Filters and Consistency-Based Approaches for Monitoring and Diagnosis of Stochastic Hybrid Systems

NASA Technical Reports Server (NTRS)

Narasimhan, Sriram; Dearden, Richard; Benazera, Emmanuel

2004-01-01

Fault detection and isolation are critical tasks to ensure correct operation of systems. When we consider stochastic hybrid systems, diagnosis algorithms need to track both the discrete mode and the continuous state of the system in the presence of noise. Deterministic techniques like Livingstone cannot deal with the stochasticity in the system and models. Conversely Bayesian belief update techniques such as particle filters may require many computational resources to get a good approximation of the true belief state. In this paper we propose a fault detection and isolation architecture for stochastic hybrid systems that combines look-ahead Rao-Blackwellized Particle Filters (RBPF) with the Livingstone 3 (L3) diagnosis engine. In this approach RBPF is used to track the nominal behavior, a novel n-step prediction scheme is used for fault detection and L3 is used to generate a set of candidates that are consistent with the discrepant observations which then continue to be tracked by the RBPF scheme.

Intracellular microrheology of motile Amoeba proteus.

PubMed

Rogers, Salman S; Waigh, Thomas A; Lu, Jian R

2008-04-15

The motility of Amoeba proteus was examined using the technique of passive particle tracking microrheology, with the aid of newly developed particle tracking software, a fast digital camera, and an optical microscope. We tracked large numbers of endogeneous particles in the amoebae, which displayed subdiffusive motion at short timescales, corresponding to thermal motion in a viscoelastic medium, and superdiffusive motion at long timescales due to the convection of the cytoplasm. Subdiffusive motion was characterized by a rheological scaling exponent of 3/4 in the cortex, indicative of the semiflexible dynamics of the actin fibers. We observed shear-thinning in the flowing endoplasm, where exponents increased with increasing flow rate; i.e., the endoplasm became more fluid-like. The rheology of the cortex is found to be isotropic, reflecting an isotropic actin gel. A clear difference was seen between cortical and endoplasmic layers in terms of both viscoelasticity and flow velocity, where the profile of the latter is close to a Poiseuille flow for a Newtonian fluid.

Intracellular Microrheology of Motile Amoeba proteus

PubMed Central

Rogers, Salman S.; Waigh, Thomas A.; Lu, Jian R.

2008-01-01

The motility of Amoeba proteus was examined using the technique of passive particle tracking microrheology, with the aid of newly developed particle tracking software, a fast digital camera, and an optical microscope. We tracked large numbers of endogeneous particles in the amoebae, which displayed subdiffusive motion at short timescales, corresponding to thermal motion in a viscoelastic medium, and superdiffusive motion at long timescales due to the convection of the cytoplasm. Subdiffusive motion was characterized by a rheological scaling exponent of 3/4 in the cortex, indicative of the semiflexible dynamics of the actin fibers. We observed shear-thinning in the flowing endoplasm, where exponents increased with increasing flow rate; i.e., the endoplasm became more fluid-like. The rheology of the cortex is found to be isotropic, reflecting an isotropic actin gel. A clear difference was seen between cortical and endoplasmic layers in terms of both viscoelasticity and flow velocity, where the profile of the latter is close to a Poiseuille flow for a Newtonian fluid. PMID:18192370

Intracellular Microrheology of Motile Amoeba proteus

NASA Astrophysics Data System (ADS)

Rogers, S.; Waigh, T.; Lu, J.

2008-04-01

The motility of motile Amoeba proteus was examined using the technique of passive particle tracking microrheology, with the aid of newly-developed particle tracking software, a fast digital camera and an optical microscope. We tracked large numbers of endogeneous particles in the amoebae, which displayed subdiffusive motion at short time scales, corresponding to thermal motion in a viscoelastic medium, and superdiffusive motion at long time scales due to the convection of the cytoplasm. Subdiffusive motion was characterised by a rheological scaling exponent of 3/4 in the cortex, indicative of the semiflexible dynamics of the actin fibres. We observed shear-thinning in the flowing endoplasm, where exponents increased with increasing flow rate; i.e. the endoplasm became more fluid-like. The rheology of the cortex is found to be isotropic, reflecting an isotropic actin gel. A clear difference was seen between cortical and endoplasmic layers in terms of both viscoelasticity and flow velocity, where the profile of the latter is close to a Poiseuille flow for a Newtonian fluid.

Design of a new tracking device for on-line beam range monitor in carbon therapy.

PubMed

Traini, Giacomo; Battistoni, Giuseppe; Bollella, Angela; Collamati, Francesco; De Lucia, Erika; Faccini, Riccardo; Ferroni, Fernando; Frallicciardi, Paola Maria; Mancini-Terracciano, Carlo; Marafini, Michela; Mattei, Ilaria; Miraglia, Federico; Muraro, Silvia; Paramatti, Riccardo; Piersanti, Luca; Pinci, Davide; Rucinski, Antoni; Russomando, Andrea; Sarti, Alessio; Sciubba, Adalberto; Senzacqua, Martina; Solfaroli-Camillocci, Elena; Toppi, Marco; Voena, Cecilia; Patera, Vincenzo

2017-02-01

Charged particle therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbon ions. A critical issue is the monitoring of the beam range so to check the correct dose deposition to the tumor and surrounding tissues. The design of a new tracking device for beam range real-time monitoring in pencil beam carbon ion therapy is presented. The proposed device tracks secondary charged particles produced by beam interactions in the patient tissue and exploits the correlation of the charged particle emission profile with the spatial dose deposition and the Bragg peak position. The detector, currently under construction, uses the information provided by 12 layers of scintillating fibers followed by a plastic scintillator and a pixelated Lutetium Fine Silicate (LFS) crystal calorimeter. An algorithm to account and correct for emission profile distortion due to charged secondaries absorption inside the patient tissue is also proposed. Finally detector reconstruction efficiency for charged particle emission profile is evaluated using a Monte Carlo simulation considering a quasi-realistic case of a non-homogenous phantom. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

A deterministic mathematical model for bidirectional excluded flow with Langmuir kinetics.

PubMed

Zarai, Yoram; Margaliot, Michael; Tuller, Tamir

2017-01-01

In many important cellular processes, including mRNA translation, gene transcription, phosphotransfer, and intracellular transport, biological "particles" move along some kind of "tracks". The motion of these particles can be modeled as a one-dimensional movement along an ordered sequence of sites. The biological particles (e.g., ribosomes or RNAPs) have volume and cannot surpass one another. In some cases, there is a preferred direction of movement along the track, but in general the movement may be bidirectional, and furthermore the particles may attach or detach from various regions along the tracks. We derive a new deterministic mathematical model for such transport phenomena that may be interpreted as a dynamic mean-field approximation of an important model from mechanical statistics called the asymmetric simple exclusion process (ASEP) with Langmuir kinetics. Using tools from the theory of monotone dynamical systems and contraction theory we show that the model admits a unique steady-state, and that every solution converges to this steady-state. Furthermore, we show that the model entrains (or phase locks) to periodic excitations in any of its forward, backward, attachment, or detachment rates. We demonstrate an application of this phenomenological transport model for analyzing ribosome drop off in mRNA translation.

Compact 3D Camera for Shake-the-Box Particle Tracking

NASA Astrophysics Data System (ADS)

Hesseling, Christina; Michaelis, Dirk; Schneiders, Jan

2017-11-01

Time-resolved 3D-particle tracking usually requires the time-consuming optical setup and calibration of 3 to 4 cameras. Here, a compact four-camera housing has been developed. The performance of the system using Shake-the-Box processing (Schanz et al. 2016) is characterized. It is shown that the stereo-base is large enough for sensible 3D velocity measurements. Results from successful experiments in water flows using LED illumination are presented. For large-scale wind tunnel measurements, an even more compact version of the system is mounted on a robotic arm. Once calibrated for a specific measurement volume, the necessity for recalibration is eliminated even when the system moves around. Co-axial illumination is provided through an optical fiber in the middle of the housing, illuminating the full measurement volume from one viewing direction. Helium-filled soap bubbles are used to ensure sufficient particle image intensity. This way, the measurement probe can be moved around complex 3D-objects. By automatic scanning and stitching of recorded particle tracks, the detailed time-averaged flow field of a full volume of cubic meters in size is recorded and processed. Results from an experiment at TU-Delft of the flow field around a cyclist are shown.

Particle Tracking on the BNL Relativistic Heavy Ion Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dell, G. F.

1986-08-07

Tracking studies including the effects of random multipole errors as well as the effects of random and systematic multipole errors have been made for RHIC. Initial results for operating at an off diagonal working point are discussed.

Annealing kinetics of latent particle tracks in Durango apatite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Afra, B.; Rodriguez, M. D.; Giulian, R.

2011-02-01

Using synchrotron small-angle x-ray scattering we determine the ''latent'' track morphology and the track annealing kinetics in the Durango apatite. The latter, measured during ex situ and in situ annealing experiments, suggests structural relaxation followed by recrystallization of the damaged material. The resolution of fractions of a nanometer with which the track radii are determined, as well as the nondestructive, artefact-free measurement methodology shown here, provides an effective means for in-depth studies of ion-track formation in natural minerals under a wide variety of geological conditions.

Annealing kinetics of latent particle tracks in Durango apatite

NASA Astrophysics Data System (ADS)

Afra, B.; Lang, M.; Rodriguez, M. D.; Zhang, J.; Giulian, R.; Kirby, N.; Ewing, R. C.; Trautmann, C.; Toulemonde, M.; Kluth, P.

2011-02-01

Using synchrotron small-angle x-ray scattering we determine the “latent” track morphology and the track annealing kinetics in the Durango apatite. The latter, measured during ex situ and in situ annealing experiments, suggests structural relaxation followed by recrystallization of the damaged material. The resolution of fractions of a nanometer with which the track radii are determined, as well as the nondestructive, artefact-free measurement methodology shown here, provides an effective means for in-depth studies of ion-track formation in natural minerals under a wide variety of geological conditions.

Coherent structures and anomalous transport in reversed field pinch plasmas

NASA Astrophysics Data System (ADS)

Antoni, V.; Drake, J. R.; Spada, E.; Spolaore, M.; Vianello, N.; Bergsåker, H.; Cavazzana, R.; Cecconello, M.; Martines, E.; Serianni, G.

2006-02-01

The results leading to the identification of coherent structures emerging from the background turbulence in the edge region of the reversed field pinch experiments EXTRAP-T2R and RFX are reviewed. These structures have traits of vortices in velocity field and blobs in density, and the reconstruction of their spatial structure and of their time evolution is discussed focusing on the analysis tools applied. The role of these structures in the particle anomalous transport is addressed, showing that their collisions can contribute up to 50% the total particle losses.This process is shown to be responsible for bursts in particle flux and it is found to set a characteristic collision time, which is in agreement with the statistical properties of laminar times for particle flux bursts.

A study of commercially-available polyethylene terephthalate (PET) and polycarbonate as nuclear track detector materials

NASA Astrophysics Data System (ADS)

Espinosa, G.; Golzarri, J. I.; Vazquez-Lopez, C.; Trejo, R.; Lopez, K.; Rickards, J.

2014-07-01

In the study of the sensitivity of materials to be used as nuclear track detectors, it was found that commercial polyethylene terephthalate (PET) from Ciel® water bottles, commercial roof cover polycarbonate, and recycled packaging strips (recycled PET), can be used as nuclear track detectors. These three commercial materials present nuclear tracks when bombarded by 2.27 MeV nitrogen ions produced in a Pelletron particle accelerator, and by fission fragments from a 252Cf source (79.4 and 103.8 MeV), after a chemical etching with a 6.25M KOH solution, or with a 6.25M KOH solution with 20% methanol, both solutions at 60±1°C. As an example, the nitrogen ions deposit approximately 1 keV/nm in the form of ionization and excitation at the surface of PET, as calculated using the SRIM code. The fission fragments deposit up to 9 keV/nm at the surface, in both cases generating sufficient free radicals to initiate the track formation process. However, 5 MeV alpha particles, typical of radon (222Rn) emissions, deposit only 0.12 keV/nm, do not present tracks after the chemical etching process. This valuable information could be very useful for further studies of new materials in nuclear track methodology.

Quantitative Identification of the Annealing Degree of Apatite Fission Tracks Using Terahertz Time Domain Spectroscopy (THz-TDS).

PubMed

Wu, Hang; Wu, Shixiang; Qiu, Nansheng; Chang, Jian; Bao, Rima; Zhang, Xin; Liu, Nian; Liu, Shuai

2018-01-01

Apatite fission-track (AFT) analysis, a widely used low-temperature thermochronology method, can provide details of the hydrocarbon generation history of source rocks for use in hydrocarbon exploration. The AFT method is based on the annealing behavior of fission tracks generated by 238 U fission in apatite particles during geological history. Due to the cumbersome experimental steps and high expense, it is imperative to find an efficient and inexpensive technique to determinate the annealing degree of AFT. In this study, on the basis of the ellipsoid configuration of tracks, the track volume fraction model (TVFM) is established and the fission-track volume index is proposed. Furthermore, terahertz time domain spectroscopy (THz-TDS) is used for the first time to identify the variation of the AFT annealing degree of Durango apatite particles heated at 20, 275, 300, 325, 450, and 500 ℃ for 10 h. The THz absorbance of the sample increases with the degree of annealing. In addition, the THz absorption index is exponentially related to annealing temperature and can be used to characterize the fission-track volume index. Terahertz time domain spectroscopy can be an ancillary technique for AFT thermochronological research. More work is urgently needed to extrapolate experimental data to geological conditions.

Multicolor Three-Dimensional Tracking for Single-Molecule Fluorescence Resonance Energy Transfer Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Aaron M.; DeVore, Matthew S.; Stich, Dominik G.

Single-molecule fluorescence resonance energy transfer (smFRET) remains a widely utilized and powerful tool for quantifying heterogeneous interactions and conformational dynamics of biomolecules. However, traditional smFRET experiments either are limited to short observation times (typically less than 1 ms) in the case of “burst” confocal measurements or require surface immobilization which usually has a temporal resolution limited by the camera framing rate. We developed a smFRET 3D tracking microscope that is capable of observing single particles for extended periods of time with high temporal resolution. The confocal tracking microscope utilizes closed-loop feedback to follow the particle in solution by recentering itmore » within two overlapping tetrahedral detection elements, corresponding to donor and acceptor channels. We demonstrated the microscope’s multicolor tracking capability via random walk simulations and experimental tracking of 200 nm fluorescent beads in water with a range of apparent smFRET efficiency values, 0.45-0.69. We also demonstrated the microscope’s capability to track and quantify double-stranded DNA undergoing intramolecular smFRET in a viscous glycerol solution. In future experiments, the smFRET 3D tracking system will be used to study protein conformational dynamics while diffusing in solution and native biological environments with high temporal resolution.« less

Multicolor Three-Dimensional Tracking for Single-Molecule Fluorescence Resonance Energy Transfer Measurements

DOE PAGES

Keller, Aaron M.; DeVore, Matthew S.; Stich, Dominik G.; ...

2018-04-19

Single-molecule fluorescence resonance energy transfer (smFRET) remains a widely utilized and powerful tool for quantifying heterogeneous interactions and conformational dynamics of biomolecules. However, traditional smFRET experiments either are limited to short observation times (typically less than 1 ms) in the case of “burst” confocal measurements or require surface immobilization which usually has a temporal resolution limited by the camera framing rate. We developed a smFRET 3D tracking microscope that is capable of observing single particles for extended periods of time with high temporal resolution. The confocal tracking microscope utilizes closed-loop feedback to follow the particle in solution by recentering itmore » within two overlapping tetrahedral detection elements, corresponding to donor and acceptor channels. We demonstrated the microscope’s multicolor tracking capability via random walk simulations and experimental tracking of 200 nm fluorescent beads in water with a range of apparent smFRET efficiency values, 0.45-0.69. We also demonstrated the microscope’s capability to track and quantify double-stranded DNA undergoing intramolecular smFRET in a viscous glycerol solution. In future experiments, the smFRET 3D tracking system will be used to study protein conformational dynamics while diffusing in solution and native biological environments with high temporal resolution.« less

Three-dimensional particle tracking velocimetry using dynamic vision sensors

NASA Astrophysics Data System (ADS)

Borer, D.; Delbruck, T.; Rösgen, T.

2017-12-01

A fast-flow visualization method is presented based on tracking neutrally buoyant soap bubbles with a set of neuromorphic cameras. The "dynamic vision sensors" register only the changes in brightness with very low latency, capturing fast processes at a low data rate. The data consist of a stream of asynchronous events, each encoding the corresponding pixel position, the time instant of the event and the sign of the change in logarithmic intensity. The work uses three such synchronized cameras to perform 3D particle tracking in a medium sized wind tunnel. The data analysis relies on Kalman filters to associate the asynchronous events with individual tracers and to reconstruct the three-dimensional path and velocity based on calibrated sensor information.

Conditioning of MVM '73 radio-tracking data

NASA Technical Reports Server (NTRS)

Koch, R. E.; Chao, C. C.; Winn, F. B.; Yip, K. W.

1974-01-01

An extensive effort was undertaken to edit Mariner 10 radiometric tracking data. Interactive computer graphics were used for the first time by an interplanetary mission to detect blunder points and spurious signatures in the data. Interactive graphics improved the former process time by a factor of 10 to 20, while increasing reliability. S/X dual Doppler data was used for the first time to calibrate charged particles in the tracking medium. Application of the charged particle calibrations decreased the orbit determination error for a short data arc following the 16 March 1974 maneuver by about 80%. A new model was developed to calibrate the earth's troposphere with seasonal adjustments. The new model has a 2% accuracy and is 5 times better than the old model.

Three-dimensional particle tracking velocimetry algorithm based on tetrahedron vote

NASA Astrophysics Data System (ADS)

Cui, Yutong; Zhang, Yang; Jia, Pan; Wang, Yuan; Huang, Jingcong; Cui, Junlei; Lai, Wing T.

2018-02-01

A particle tracking velocimetry algorithm based on tetrahedron vote, which is named TV-PTV, is proposed to overcome the limited selection problem of effective algorithms for 3D flow visualisation. In this new cluster-matching algorithm, tetrahedrons produced by the Delaunay tessellation are used as the basic units for inter-frame matching, which results in a simple algorithmic structure of only two independent preset parameters. Test results obtained using the synthetic test image data from the Visualisation Society of Japan show that TV-PTV presents accuracy comparable to that of the classical algorithm based on new relaxation method (NRX). Compared with NRX, TV-PTV possesses a smaller number of loops in programming and thus a shorter computing time, especially for large particle displacements and high particle concentration. TV-PTV is confirmed practically effective using an actual 3D wake flow.

A Preliminary Comparison of Three Dimensional Particle Tracking and Sizing using Plenoptic Imaging and Digital In-line Holography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guildenbecher, Daniel Robert; Munz, Elise Dahnke; Farias, Paul Abraham

2015-12-01

Digital in-line holography and plenoptic photography are two techniques for single-shot, volumetric measurement of 3D particle fields. Here we present a preliminary comparison of the two methods by applying plenoptic imaging to experimental configurations that have been previously investigated with digital in-line holography. These experiments include the tracking of secondary droplets from the impact of a water drop on a thin film of water and tracking of pellets from a shotgun. Both plenoptic imaging and digital in-line holography successfully quantify the 3D nature of these particle fields. This includes measurement of the 3D particle position, individual particle sizes, and three-componentmore » velocity vectors. For the initial processing methods presented here, both techniques give out-of-plane positional accuracy of approximately 1-2 particle diameters. For a fixed image sensor, digital holography achieves higher effective in-plane spatial resolutions. However, collimated and coherent illumination makes holography susceptible to image distortion through index of refraction gradients, as demonstrated in the shotgun experiments. On the other hand, plenotpic imaging allows for a simpler experimental configuration. Furthermore, due to the use of diffuse, white-light illumination, plenoptic imaging is less susceptible to image distortion in the shotgun experiments. Additional work is needed to better quantify sources of uncertainty, particularly in the plenoptic experiments, as well as develop data processing methodologies optimized for the plenoptic measurement.« less

A Preliminary Comparison of Three Dimensional Particle Tracking and Sizing using Plenoptic Imaging and Digital In-line Holography [PowerPoint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guildenbecher, Daniel Robert; Munz, Elise Dahnke; Farias, Paul Abraham

2015-12-01

Digital in-line holography and plenoptic photography are two techniques for single-shot, volumetric measurement of 3D particle fields. Here we present a preliminary comparison of the two methods by applying plenoptic imaging to experimental configurations that have been previously investigated with digital in-line holography. These experiments include the tracking of secondary droplets from the impact of a water drop on a thin film of water and tracking of pellets from a shotgun. Both plenoptic imaging and digital in-line holography successfully quantify the 3D nature of these particle fields. This includes measurement of the 3D particle position, individual particle sizes, and three-componentmore » velocity vectors. For the initial processing methods presented here, both techniques give out-of-plane positional accuracy of approximately 1-2 particle diameters. For a fixed image sensor, digital holography achieves higher effective in-plane spatial resolutions. However, collimated and coherent illumination makes holography susceptible to image distortion through index of refraction gradients, as demonstrated in the shotgun experiments. On the other hand, plenotpic imaging allows for a simpler experimental configuration. Furthermore, due to the use of diffuse, white-light illumination, plenoptic imaging is less susceptible to image distortion in the shotgun experiments. Additional work is needed to better quantify sources of uncertainty, particularly in the plenoptic experiments, as well as develop data processing methodologies optimized for the plenoptic measurement.« less

Reverse transcriptase activity and particles of retroviral density in cultured canine lymphosarcoma supernatants.

PubMed Central

Tomley, F. M.; Armstrong, S. J.; Mahy, B. W.; Owen, L. N.

1983-01-01

Lymphoid tissue from 43 cases of canine lymphosarcoma and from 40 clinically normal dogs have been examined for markers of retrovirus infection. From 69-76% of culture supernatants from lymphosarcomas were shown to contain particles of retroviral density and to possess poly rC-oligo dG templated polymerase (reverse transcriptase) activity compared with 17-24% of culture supernatants from normal canine lymphoid cells. In 6 culture supernatants from cases of lymphosarcoma, high molecular weight 60-70S RNA was detected and shown to be found in association with this particulate reverse transcriptase activity. No such RNA was detected in 6 culture supernatants from normal canine lymphoid cells. PMID:6186265

Tailoring superelasticity of soft magnetic materials

NASA Astrophysics Data System (ADS)

Cremer, Peet; Löwen, Hartmut; Menzel, Andreas M.

2015-10-01

Embedding magnetic colloidal particles in an elastic polymer matrix leads to smart soft materials that can reversibly be addressed from outside by external magnetic fields. We discover a pronounced nonlinear superelastic stress-strain behavior of such materials using numerical simulations. This behavior results from a combination of two stress-induced mechanisms: a detachment mechanism of embedded particle aggregates and a reorientation mechanism of magnetic moments. The superelastic regime can be reversibly tuned or even be switched on and off by external magnetic fields and thus be tailored during operation. Similarities to the superelastic behavior of shape-memory alloys suggest analogous applications, with the additional benefit of reversible switchability and a higher biocompatibility of soft materials.

Target productions in forward and backward hemispheres in the interactions of 28Si-EM at 14.6A GeV

NASA Astrophysics Data System (ADS)

Abdelsalam, A.; El-Nagdy, M. S.; Abdalla, A. M.; Saber, A.

2015-11-01

This paper search for the results and properties of slow particle productions, appear as a gray and black tracks in nuclear emulsions, producing secondary charged particles which are emitted from 28Si interactions with emulsion nuclei at 14.6A GeV. The forward particles emission of interactions, (θlab<90∘) as well as the backward ones (θlab≥90∘), have been investigated. It includes the effect of both projectile mass number and energy on the production and multiplicities of these particles. The results compared with other experiments for the same target but with different projectiles and energies. The experimental data show that there are two different mechanisms responsible for the production of gray particles for the chosen channels of emission angles and each are energy dependence. This dependence is weakly on the projectile mass number. The same investigations are applied for black tracks producing particles. The experimental results show the production of these particles is purely target fragments independent on both projectile mass number and its energy. The anisotropy ratio of angular distribution (F/B) is applied for both kinds of particles which are found the value for gray particle production depends on the direction of emissions while it is unchanged for black particles.

High-Performance Reactive Particle Tracking with Adaptive Representation

NASA Astrophysics Data System (ADS)

Schmidt, M.; Benson, D. A.; Pankavich, S.

2017-12-01

Lagrangian particle tracking algorithms have been shown to be effective tools for modeling chemical reactions in imperfectly-mixed media. One disadvantage of these algorithms is the possible need to employ large numbers of particles in simulations, depending on the concentration covariance structure, and these large particle numbers can lead to long computation times. Two distinct approaches have recently arisen to overcome this. One method employs spatial kernels that are related to a specified, reduced particle number; however, over-wide kernels, dictated by a very low particle number, lead to an excess of reaction calculations and cause a reduction in performance. Another formulation involves hybrid particles that carry multiple species of reactant, wherein each particle is treated as its own well-mixed volume, obviating the need for large numbers of particles for each species but still requiring a fixed number of hybrid particles. Here, we combine these two approaches and demonstrate an improved method for simulating a given system in a computationally efficient manner. Additionally, the independent nature of transport and reaction calculations in this approach allows for significant gains via parallelization in an MPI or OpenMP context. For benchmarking, we choose a CO2 injection simulation with dissolution and precipitation of calcite and dolomite, allowing us to derive the proper treatment of interaction between solid and aqueous phases.

The Biological Effectiveness of Accelerated Particles for the Induction of Chromosome Damage: Track Structure Effects and Cytogenetic Signatures of High-LET Exposure

NASA Technical Reports Server (NTRS)

George, K.; Hada, M.; Chappell, L.; Cucinotta, F. A.

2012-01-01

Track structure models predict that at a fixed value of LET, particles with lower charge number, Z will have a higher biological effectiveness compared to particles with a higher Z. In this report we investigated how track structure effects induction of chromosomal aberration in human cells. Human lymphocytes were irradiated in vitro with various energies of accelerated iron, silicon, neon, or titanium ions and chromosome damage was assessed in using three color FISH chromosome painting in chemically induced PCC samples collected a first cell division post irradiation. The LET values for these ions ranged from 30 to 195 keV/micrometers. Of the particles studied, Neon ions have the highest biological effectiveness for induction of total chromosome damage, which is consistent with track structure model predictions. For complex-type exchanges 64 MeV/ u Neon and 450 MeV/u Iron were equally effective and induced the most complex damage. In addition we present data on chromosomes exchanges induced by six different energies of protons (5 MeV/u to 2.5 GeV/u). The linear dose response term was similar for all energies of protons suggesting that the effect of the higher LET at low proton energies is balanced by the production of nuclear secondaries from the high energy protons. All energies of protons have a much higher percentage of complex-type chromosome exchanges than gamma rays, signifying a cytogenetic signature for proton exposures.

Design of a tracking device for on-line dose monitoring in hadrontherapy

NASA Astrophysics Data System (ADS)

Battistoni, G.; Collamati, F.; De Lucia, E.; Faccini, R.; Marafini, M.; Mattei, I.; Muraro, S.; Paramatti, R.; Patera, V.; Pinci, D.; Rucinski, A.; Russomando, A.; Sarti, A.; Sciubba, A.; Solfaroli Camillocci, E.; Toppi, M.; Traini, G.; Voena, C.

2017-02-01

Hadrontherapy is a technique for cancer treatment that exploits ion beams (mostly protons and carbons). A critical issue is the accuracy that is achievable when monitoring the dose released by the beam to the tumor and to the surrounding tissues. We present the design of a tracking device, developed in the framework of the INSIDE project [1], capable of monitoring in real time the longitudinal profile of the dose delivered in the patient. This is possible by detecting the secondary particles produced by the interaction of the beam in the tissues. The position of the Bragg peak can be correlated to the charged particles emission point distribution measurement. The tracking device will be able to provide a fast response on the dose pattern by tracking the secondary charged fragments. The tracks are detected using 6 planes of scintillating fibers, providing the 3D coordinates of the track intersection with each plane. The fibers planes are followed by a plastic scintillator and by a small calorimeter built with a pixelated Lutetium Fine Silicate (LFS) crystal. A complete detector simulation, followed by the event reconstruction, has been performed to determine the achievable monitoring spatial resolution.

Molecular motors interacting with their own tracks

NASA Astrophysics Data System (ADS)

Artyomov, Max N.; Morozov, Alexander Yu.; Kolomeisky, Anatoly B.

2008-04-01

Dynamics of molecular motors that move along linear lattices and interact with them via reversible destruction of specific lattice bonds is investigated theoretically by analyzing exactly solvable discrete-state “burnt-bridge” models. Molecular motors are viewed as diffusing particles that can asymmetrically break or rebuild periodically distributed weak links when passing over them. Our explicit calculations of dynamic properties show that coupling the transport of the unbiased molecular motor with the bridge-burning mechanism leads to a directed motion that lowers fluctuations and produces a dynamic transition in the limit of low concentration of weak links. Interaction between the backward biased molecular motor and the bridge-burning mechanism yields a complex dynamic behavior. For the reversible dissociation the backward motion of the molecular motor is slowed down. There is a change in the direction of the molecular motor’s motion for some range of parameters. The molecular motor also experiences nonmonotonic fluctuations due to the action of two opposing mechanisms: the reduced activity after the burned sites and locking of large fluctuations. Large spatial fluctuations are observed when two mechanisms are comparable. The properties of the molecular motor are different for the irreversible burning of bridges where the velocity and fluctuations are suppressed for some concentration range, and the dynamic transition is also observed. Dynamics of the system is discussed in terms of the effective driving forces and transitions between different diffusional regimes.

The Influence of Turbulent Coherent Structure on Suspended Sediment Transport

NASA Astrophysics Data System (ADS)

Huang, S. H.; Tsai, C.

2017-12-01

The anomalous diffusion of turbulent sedimentation has received more and more attention in recent years. With the advent of new instruments and technologies, researchers have found that sediment behavior may deviate from Fickian assumptions when particles are heavier. In particle-laden flow, bursting phenomena affects instantaneous local concentrations, and seems to carry suspended particles for a longer distance. Instead of the pure diffusion process in an analogy to Brownian motion, Levy flight which allows particles to move in response to bursting phenomena is suspected to be more suitable for describing particle movement in turbulence. And the fractional differential equation is a potential candidate to improve the concentration profile. However, stochastic modeling (the Differential Chapmen-Kolmogorov Equation) also provides an alternative mathematical framework to describe system transits between different states through diffusion/the jump processes. Within this framework, the stochastic particle tracking model linked with advection diffusion equation is a powerful tool to simulate particle locations in the flow field. By including the jump process to this model, a more comprehensive description for suspended sediment transport can be provided with a better physical insight. This study also shows the adaptability and expandability of the stochastic particle tracking model for suspended sediment transport modeling.

Assessing the dietary bioavailability of metals associated with natural particles: Extending the use of the reverse labeling approach to zinc

USGS Publications Warehouse

Croteau, Marie-Noele; Cain, Daniel J.; Fuller, Christopher C.

2017-01-01

We extend the use of a novel tracing technique to quantify the bioavailability of zinc (Zn) associated with natural particles using snails enriched with a less common Zn stable isotope. Lymnaea stagnalis is a model species that has relatively fast Zn uptake rates from the dissolved phase, enabling their rapid enrichment in 67Zn during the initial phase of labeling. Isotopically enriched snails were subsequently exposed to algae mixed with increasing amounts of metal-rich particles collected from two acid mine drainage impacted rivers. Zinc bioavailability from the natural particles was inferred from calculations of 66Zn assimilation into the snail’s soft tissues. Zinc assimilation efficiency (AE) varied from 28% for the Animas River particles to 45% for the Snake River particles, indicating that particle-bound, or sorbed Zn, was bioavailable from acid mine drainage wastes. The relative binding strength of Zn sorption to the natural particles was inversely related to Zn bioavailability; a finding that would not have been possible without using the reverse labeling approach. Differences in the chemical composition of the particles suggest that their geochemical properties may influence the extent of Zn bioavailability.

Propulsion of Active Colloids by Self-Induced Field Gradients.

PubMed

Boymelgreen, Alicia; Yossifon, Gilad; Miloh, Touvia

2016-09-20

Previously, metallodielectric Janus particles have been shown to travel with their dielectric hemisphere forward under low frequency applied electric fields as a result of asymmetric induced-charge electroosmotic flow. Here, it is demonstrated that at high frequencies, well beyond the charge relaxation time of the electric double layer induced around the particle, rather than the velocity decaying to zero, the Janus particles reverse direction, traveling with their metallic hemisphere forward. It is proposed that such motion is the result of a surface force, arising from localized nonuniform electric field gradients, induced by the dual symmetry-breaking of an asymmetric particle adjacent to a wall, which act on the induced dipole of the particle to drive net motion even in a uniform AC field. Although the field is external, since the driving gradient is induced on the particle level, it may be considered an active colloid. We have thus termed this propulsion mechanism "self-dielectrophoresis", to distinguish from traditional dielectrophoresis where the driving nonuniform field is externally fixed and the particle direction is restricted. It is demonstrated theoretically and experimentally that the critical frequency at which the particle reverses direction can be characterized by a nondimensional parameter which is a function of electrolyte concentration and particle size.

Assessing the Dietary Bioavailability of Metals Associated with Natural Particles: Extending the Use of the Reverse Labeling Approach to Zinc.

PubMed

Croteau, Marie-Noële; Cain, Daniel J; Fuller, Christopher C

2017-03-07

We extend the use of a novel tracing technique to quantify the bioavailability of zinc (Zn) associated with natural particles using snails enriched with a less common Zn stable isotope. Lymnaea stagnalis is a model species that has relatively fast Zn uptake rates from the dissolved phase, enabling their rapid enrichment in 67 Zn during the initial phase of labeling. Isotopically enriched snails were subsequently exposed to algae mixed with increasing amounts of metal-rich particles collected from two acid mine drainage impacted rivers. Zinc bioavailability from the natural particles was inferred from calculations of 66 Zn assimilation into the snail's soft tissues. Zinc assimilation efficiency (AE) varied from 28% for the Animas River particles to 45% for the Snake River particles, indicating that particle-bound, or sorbed Zn, was bioavailable from acid mine drainage wastes. The relative binding strength of Zn sorption to the natural particles was inversely related to Zn bioavailability; a finding that would not have been possible without using the reverse labeling approach. Differences in the chemical composition of the particles suggest that their geochemical properties may influence the extent of Zn bioavailability.

Investigations of stacking fault density in perpendicular recording media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piramanayagam, S. N., E-mail: prem-SN@dsi.a-star.edu.sg; Varghese, Binni; Yang, Yi

In magnetic recording media, the grains or clusters reverse their magnetization over a range of reversal field, resulting in a switching field distribution. In order to achieve high areal densities, it is desirable to understand and minimize such a distribution. Clusters of grains which contain stacking faults (SF) or fcc phase have lower anisotropy, an order lower than those without them. It is believed that such low anisotropy regions reverse their magnetization at a much lower reversal field than the rest of the material with a larger anisotropy. Such clusters/grains cause recording performance deterioration, such as adjacent track erasure andmore » dc noise. Therefore, the observation of clusters that reverse at very low reversal fields (nucleation sites, NS) could give information on the noise and the adjacent track erasure. Potentially, the observed clusters could also provide information on the SF. In this paper, we study the reversal of nucleation sites in granular perpendicular media based on a magnetic force microscope (MFM) methodology and validate the observations with high resolution cross-section transmission electron microscopy (HRTEM) measurements. Samples, wherein a high anisotropy CoPt layer was introduced to control the NS or SF in a systematic way, were evaluated by MFM, TEM, and magnetometry. The magnetic properties indicated that the thickness of the CoPt layer results in an increase of nucleation sites. TEM measurements indicated a correlation between the thickness of CoPt layer and the stacking fault density. A clear correlation was also observed between the MFM results, TEM observations, and the coercivity and nucleation field of the samples, validating the effectiveness of the proposed method in evaluating the nucleation sites which potentially arise from stacking faults.« less

Magnetic field evolution and reversals in spiral galaxies

NASA Astrophysics Data System (ADS)

Dobbs, C. L.; Price, D. J.; Pettitt, A. R.; Bate, M. R.; Tricco, T. S.

2016-10-01

We study the evolution of galactic magnetic fields using 3D smoothed particle magnetohydrodynamics (SPMHD) simulations of galaxies with an imposed spiral potential. We consider the appearance of reversals of the field, and amplification of the field. We find that magnetic field reversals occur when the velocity jump across the spiral shock is above ≈20 km s-1, occurring where the velocity change is highest, typically at the inner Lindblad resonance in our models. Reversals also occur at corotation, where the direction of the velocity field reverses in the corotating frame of a spiral arm. They occur earlier with a stronger amplitude spiral potential, and later or not at all with weaker or no spiral arms. The presence of a reversal at radii of around 4-6 kpc in our fiducial model is consistent with a reversal identified in the Milky Way, though we caution that alternative Galaxy models could give a similar reversal. We find that relatively high resolution, a few million particles in SPMHD, is required to produce consistent behaviour of the magnetic field. Amplification of the magnetic field occurs in the models, and while some may be genuinely attributable to differential rotation or spiral arms, some may be a numerical artefact. We check our results using ATHENA, finding reversals but less amplification of the field, suggesting that some of the amplification of the field with SPMHD is numerical.

Tracking system analytic calibration activities for the Mariner Mars 1971 mission

NASA Technical Reports Server (NTRS)

Madrid, G. A.; Chao, C. C.; Fliegel, H. F.; Leavitt, R. K.; Mottinger, N. A.; Winn, F. B.; Wimberly, R. N.; Yip, K. B.; Zielenbach, J. W.

1974-01-01

Data covering various planning aspects of Mariner Mars 1971 mission are summarized. Data cover calibrating procedures for tracking stations, radio signal propagation in the troposphere, effects of charged particles on radio transmission, orbit calculation, and data smoothing.