Suborbital Research and Development Opportunities

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.

2011-01-01

This slide presentation reviews the new strategies for problem solving in the life sciences in the suborbital realm. Topics covered are: an overview of the space life sciences, the strategic initiatives that the Space Life Sciences organization engaged in, and the new business model that these initiatives were developed. Several opportunities for research are also reviewed.

Developing an International Pool of Certified Quality Reviewers

ERIC Educational Resources Information Center

Adair, Deborah

2017-01-01

This article covers the origins, growth, rationale, calibration, and inspiration of an international pool of certified Quality Matters™ (QM) Peer Reviewers. From the beginning in 2003, as a U.S. Department of Education, Fund for the Improvement of Postsecondary Education funded project, QM was developed as a faculty-centered, peer-based approach…

Training for Agriculture: Annual Review of Selected Developments.

ERIC Educational Resources Information Center

United Nations Food and Agriculture Organization, Rome (Italy).

The topics covered by review articles are: Training for Rural Development (with special reference to Chile); Field Training--Theory into Practice (for women extension workers in Malaysia); A New Look is Needed for Extension (Latin America); 4-D Rural Youth Clubs in Dahomey; Sociological Aspects of Rural Training; Population Education in the…

Correspondence Study; A Summary Review of the Research and Development Literature.

ERIC Educational Resources Information Center

Mathieson, David E.

Beginning with a historical review of private correspondence schools, supervised high school level programs, military programs (notable the United States Armed Forces Institute), and activities by such university extension luminaries as William Rainey Harper and W. H. Lighty, this literature review covers accreditation and licensing problems,…

American Language Review, 2000.

ERIC Educational Resources Information Center

Ward, Ben, Ed.

2000-01-01

The six issues of this journal cover a variety of topics of interest to the second language professional. Among the topics covered are the following: "virtual" classrooms, staff development, traveling with students, learner self-testing, advice on how to find a job on the Web, online pronunciation aids, language teaching strategies for deaf…

Alaska Interim Land Cover Mapping Program; final report

USGS Publications Warehouse

Fitzpatrick-Lins, Katherine; Doughty, E.F.; Shasby, Mark; Benjamin, Susan

1989-01-01

In 1985, the U.S. Geological Survey initiated a research project to develop an interim land cover data base for Alaska as an alternative to the nationwide Land Use and Land Cover Mapping Program. The Alaska Interim Land Cover Mapping Program was subsequently created to develop methods for producing a series of land cover maps that utilized the existing Landsat digital land cover classifications produced by and for the major land management agencies for mapping the vegetation of Alaska. The program was successful in producing digital land cover classifications and statistical summaries using a common statewide classification and in reformatting these data to produce l:250,000-scale quadrangle-based maps directly from the Scitex laser plotter. A Federal and State agency review of these products found considerable user support for the maps. Presently the Geological Survey is committed to digital processing of six to eight quadrangles each year.

Wasted research when systematic reviews fail to provide a complete and up-to-date evidence synthesis: the example of lung cancer.

PubMed

Créquit, Perrine; Trinquart, Ludovic; Yavchitz, Amélie; Ravaud, Philippe

2016-01-20

Multiple treatments are frequently available for a given condition, and clinicians and patients need a comprehensive, up-to-date synthesis of evidence for all competing treatments. We aimed to quantify the waste of research related to the failure of systematic reviews to provide a complete and up-to-date evidence synthesis over time. We performed a series of systematic overviews and networks of randomized trials assessing the gap between evidence covered by systematic reviews and available trials of second-line treatments for advanced non-small cell lung cancer. We searched the Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, MEDLINE, EMBASE, and other resources sequentially by year from 2009 to March 2, 2015. We sequentially compared the amount of evidence missing from systematic reviews to the randomized evidence available for inclusion each year. We constructed cumulative networks of randomized evidence over time and evaluated the proportion of trials, patients, treatments, and treatment comparisons not covered by systematic reviews on December 31 each year from 2009 to 2015. We identified 77 trials (28,636 patients) assessing 47 treatments with 54 comparisons and 29 systematic reviews (13 published after 2013). From 2009 to 2015, the evidence covered by existing systematic reviews was consistently incomplete: 45 % to 70 % of trials; 30 % to 58 % of patients; 40 % to 66 % of treatments; and 38 % to 71 % of comparisons were missing. In the cumulative networks of randomized evidence, 10 % to 17 % of treatment comparisons were partially covered by systematic reviews and 55 % to 85 % were partially or not covered. We illustrate how systematic reviews of a given condition provide a fragmented, out-of-date panorama of the evidence for all treatments. This waste of research might be reduced by the development of live cumulative network meta-analyses.

ENVIRONMENTAL MASS SPECTROMETRY: EMERGING CONTAMINANTS AND CURRENT ISSUES

EPA Science Inventory

This review covers developments in environmental mass spectrometry over the period of 2000-2001. A few significant references that appeared between January and February 2002 are also included. The previous Environmental Mass Spectrometry review was very comprehensive, including...

Water Reclamation and Reuse.

ERIC Educational Resources Information Center

Smith, Daniel W.

1978-01-01

Presents a literature review of water reclamation and reuse. This review covers: (1) water resources planning; (2) agriculture and irrigation; (3) ground recharge; (4) industrial reuse; (5) health considerations; and (6) technology developments. A list of 217 references is also presented. (HM)

78 FR 12068 - Agency Information Collection Activities: Submission to OMB for Review and Approval; Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... mandate of section 340B(a)(5)(C) to develop audit guidelines and because of the potential for disputes... guidelines for audit of covered entities. Burden Statement: Burden in this context means the time expended by... time needed to review instructions, to develop, acquire, install and utilize technology and systems for...

Software Development Group. Software Review Center. Microcomputing Working Paper Series.

ERIC Educational Resources Information Center

Perkey, Nadine; Smith, Shirley C.

Two papers describe the roles of the Software Development Group (SDG) and the Software Review Center (SRC) at Drexel University. The first paper covers the primary role of the SDG, which is designed to assist Drexel faculty with the technical design and programming of courseware for the Apple Macintosh microcomputer; the relationship of the SDG…

Proceedings of the Fuel Cells `97 Review Meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The Federal Energy Technology Center (FETC) sponsored the Fuel Cells '97 Review Meeting on August 26-28, 1997, in Morgantown, West Virginia. The purpose of the meeting was to provide an annual forum for the exchange of ideas and discussion of results and plans related to the research on fuel cell power systems. The total of almost 250 conference participants included engineers and scientists representing utilities, academia, and government from the U.S. and eleven other countries: Canada, China, India, Iran, Italy, Japan, Korea, Netherlands, Russia, Taiwan, and the United Kingdom. On first day, the conference covered the perspectives of sponsors andmore » end users, and the progress reports of fuel-cell developers. Papers covered phosphoric, carbonate, and solid oxide fuel cells for stationary power applications. On the second day, the conference covered advanced research in solid oxide and other fuel cell developments. On the third day, the conference sponsored a workshop on advanced research and technology development. A panel presentation was given on fuel cell opportunities. Breakout sessions with group discussions followed this with fuel cell developers, gas turbine vendors, and consultants.« less

Remote sensing sensors and applications in environmental resources mapping and modeling

USGS Publications Warehouse

Melesse, Assefa M.; Weng, Qihao; Thenkabail, Prasad S.; Senay, Gabriel B.

2007-01-01

The history of remote sensing and development of different sensors for environmental and natural resources mapping and data acquisition is reviewed and reported. Application examples in urban studies, hydrological modeling such as land-cover and floodplain mapping, fractional vegetation cover and impervious surface area mapping, surface energy flux and micro-topography correlation studies is discussed. The review also discusses the use of remotely sensed-based rainfall and potential evapotranspiration for estimating crop water requirement satisfaction index and hence provides early warning information for growers. The review is not an exhaustive application of the remote sensing techniques rather a summary of some important applications in environmental studies and modeling.

Environmental Mass Spectrometry: Emerging Contaminants and Current Issues (2010 Review)

EPA Science Inventory

This biennial review covers developments in environmental mass spectrometry for emerging environmental contaminants over the period of 2008-2009. A few significant references that appeared between January and February 2010 are also included. Analytical Chemistry’s current polic...

WATER ANALYSIS: EMERGING CONTAMINANTS AND CURRENT ISSUES

EPA Science Inventory

This review covers developments in Water Analysis over the period of 2001-2002. A few significant references that appeared between January and February 2003 are also included. Previous Water Analysis reviews have been very comprehensive; however, in 2001, Analytical Chemistry c...

Oil spill response capabilities and technologies for ice-covered Arctic marine waters: A review of recent developments and established practices.

PubMed

Wilkinson, Jeremy; Beegle-Krause, C J; Evers, Karl-Ulrich; Hughes, Nick; Lewis, Alun; Reed, Mark; Wadhams, Peter

2017-12-01

Renewed political and commercial interest in the resources of the Arctic, the reduction in the extent and thickness of sea ice, and the recent failings that led to the Deepwater Horizon oil spill, have prompted industry and its regulatory agencies, governments, local communities and NGOs to look at all aspects of Arctic oil spill countermeasures with fresh eyes. This paper provides an overview of present oil spill response capabilities and technologies for ice-covered waters, as well as under potential future conditions driven by a changing climate. Though not an exhaustive review, we provide the key research results for oil spill response from knowledge accumulated over many decades, including significant review papers that have been prepared as well as results from recent laboratory tests, field programmes and modelling work. The three main areas covered by the review are as follows: oil weathering and modelling; oil detection and monitoring; and oil spill response techniques.

ENVIRONMENTAL MASS SPECTROMETRY: EMERGING CONTAMINANTS AND CURRENT ISSUES, 2006

EPA Science Inventory

This biennial review covers developments in Environmental Mass Spectrometry over the period of 2004-2005. A few significant references that appeared between January and February 2006 are also included. Analytical Chemistry's current policy is to limit reviews to include 100-200 s...

Water Analysis: Emerging Contaminants and Current Issues (2009 Review)

EPA Science Inventory

This biennial review covers developments in Water Analysis for Emerging Environmental Contaminants over the period of 2007-2008. A few significant references that appeared between January and February 2009 are also included. Analytical Chemistry’s current policy is to limit rev...

Side-chain Liquid Crystal Polymers (SCLCP): Methods and Materials. An Overview

PubMed Central

Ganicz, Tomasz; Stańczyk, Włodzimierz

2009-01-01

This review focuses on recent developments in the chemistry of side chain liquid crystal polymers. It concentrates on current trends in synthetic methods and novel, well defined structures, supramolecular arrangements, properties, and applications. The review covers literature published in this century, apart from some areas, such as dendritic and elastomeric systems, which have been recently reviewed.

WATER ANALYSIS

EPA Science Inventory

This review covers developments in water analysis from November 1996 to the end of October 1998, as found in the Chemical Abstracts Service CA Selects for gas chromatography, mass spectrometry, inorganic analytical chemistry, and pollution monitoring. In addition, because develop...

The making of the Chandra X-Ray Observatory: The project scientist’s perspective

PubMed Central

Weisskopf, Martin C.

2010-01-01

The history of the development of the Chandra X-Ray Observatory is reviewed from a personal perspective. This review is necessarily biased and limited by space because it attempts to cover a time span approaching five decades. PMID:20194740

Practice Parameter for Psychiatric Consultation to Schools

ERIC Educational Resources Information Center

Journal of the American Academy of Child and Adolescent Psychiatry, 2005

2005-01-01

This practice parameter reviews the topic of psychiatric consultation to schools. The review covers the history of school consultation and current consultative models; the process of developing a consultative relationship; school administrative procedures, personnel, and milieu; legal protections for students with mental disabilities; and issues…

2005 NASA Seal/Secondary Air System Workshop, Volume 1

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M. (Editor); Hendricks, Robert C. (Editor)

2006-01-01

The 2005 NASA Seal/Secondary Air System workshop covered the following topics: (i) Overview of NASA s new Exploration Initiative program aimed at exploring the Moon, Mars, and beyond; (ii) Overview of the NASA-sponsored Propulsion 21 Project; (iii) Overview of NASA Glenn s seal project aimed at developing advanced seals for NASA s turbomachinery, space, and reentry vehicle needs; (iv) Reviews of NASA prime contractor, vendor, and university advanced sealing concepts including tip clearance control, test results, experimental facilities, and numerical predictions; and (v) Reviews of material development programs relevant to advanced seals development. Turbine engine studies have shown that reducing high-pressure turbine (HPT) blade tip clearances will reduce fuel burn, lower emissions, retain exhaust gas temperature margin, and increase range. Several organizations presented development efforts aimed at developing faster clearance control systems and associated technology to meet future engine needs. The workshop also covered several programs NASA is funding to develop technologies for the Exploration Initiative and advanced reusable space vehicle technologies. NASA plans on developing an advanced docking and berthing system that would permit any vehicle to dock to any on-orbit station or vehicle. Seal technical challenges (including space environments, temperature variation, and seal-on-seal operation) as well as plans to develop the necessary "androgynous" seal technologies were reviewed. Researchers also reviewed tests completed for the shuttle main landing gear door seals.

Novel developments and applications of two-dimensional correlation spectroscopy

NASA Astrophysics Data System (ADS)

Park, Yeonju; Noda, Isao; Jung, Young Mee

2016-11-01

A comprehensive survey review of new and noteworthy developments of 2D correlation spectroscopy (2DCOS) and its applications for the last two years is compiled. This review covers not only journal articles and book chapters but also books, proceedings, and review articles published on 2DCOS, numerous significant new concepts of 2DCOS, patents and publication trends. Noteworthy experimental practices in the field of 2DCOS, including types of analytical probes employed, various perturbation methods used in experiments, and pertinent examples of fundamental and practical applications, are also reviewed.

Changing Arctic snow cover: A review of recent developments and assessment of future needs for observations, modelling, and impacts.

PubMed

Bokhorst, Stef; Pedersen, Stine Højlund; Brucker, Ludovic; Anisimov, Oleg; Bjerke, Jarle W; Brown, Ross D; Ehrich, Dorothee; Essery, Richard L H; Heilig, Achim; Ingvander, Susanne; Johansson, Cecilia; Johansson, Margareta; Jónsdóttir, Ingibjörg Svala; Inga, Niila; Luojus, Kari; Macelloni, Giovanni; Mariash, Heather; McLennan, Donald; Rosqvist, Gunhild Ninis; Sato, Atsushi; Savela, Hannele; Schneebeli, Martin; Sokolov, Aleksandr; Sokratov, Sergey A; Terzago, Silvia; Vikhamar-Schuler, Dagrun; Williamson, Scott; Qiu, Yubao; Callaghan, Terry V

2016-09-01

Snow is a critically important and rapidly changing feature of the Arctic. However, snow-cover and snowpack conditions change through time pose challenges for measuring and prediction of snow. Plausible scenarios of how Arctic snow cover will respond to changing Arctic climate are important for impact assessments and adaptation strategies. Although much progress has been made in understanding and predicting snow-cover changes and their multiple consequences, many uncertainties remain. In this paper, we review advances in snow monitoring and modelling, and the impact of snow changes on ecosystems and society in Arctic regions. Interdisciplinary activities are required to resolve the current limitations on measuring and modelling snow characteristics through the cold season and at different spatial scales to assure human well-being, economic stability, and improve the ability to predict manage and adapt to natural hazards in the Arctic region.

Changing Arctic Snow Cover: A Review of Recent Developments and Assessment of Future Needs for Observations, Modelling, and Impacts

NASA Technical Reports Server (NTRS)

Bokhorst, Stef; Pedersen, Stine Hojlund; Brucker, Ludovic; Anisimov, Oleg; Bjerke, Jarle W.; Brown, Ross D.; Ehrich, Dorothee; Essery, Richard L. H.; Heilig, Achim; Ingvander, Susanne;

Remote Sensing Sensors and Applications in Environmental Resources Mapping and Modelling

PubMed Central

Melesse, Assefa M.; Weng, Qihao; S.Thenkabail, Prasad; Senay, Gabriel B.

2007-01-01

The history of remote sensing and development of different sensors for environmental and natural resources mapping and data acquisition is reviewed and reported. Application examples in urban studies, hydrological modeling such as land-cover and floodplain mapping, fractional vegetation cover and impervious surface area mapping, surface energy flux and micro-topography correlation studies is discussed. The review also discusses the use of remotely sensed-based rainfall and potential evapotranspiration for estimating crop water requirement satisfaction index and hence provides early warning information for growers. The review is not an exhaustive application of the remote sensing techniques rather a summary of some important applications in environmental studies and modeling. PMID:28903290

LLE Review Quarterly Report (April-June 1989). Volume 39

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simon, A.

1989-06-01

This volume of the LLE Review, covering the period April-June 1989, includes the second part of a two-part series dealing with the preliminary design of the OMEGA Upgrade. One article provides a general overview of the current upgrade system configuration and another article describes the target system. Future issues of the LLE Review will cover other aspects of the OMEGA Upgrade as the detailed system design develops. In addition, the advanced technology section of this issue contains an article discussing the interaction of a picosecond optical pulse with high temperature superconductors. Finally, the activities of the National Laser Users Facilitymore » and the GDL and OMEGA laser facilities are summarized.« less

How to Write Effective Resumes and Cover Letters.

ERIC Educational Resources Information Center

Nienkamp, Roger L.

This guide to writing effective resumes and cover letters to employers first emphasizes the value of writing skills in job hunting, and explains what a resume is and why it is important. Next, steps to undertake in preparing to write a resume are reviewed including developing a personal inventory sheet to help determine facts to include in the…

U.K. radio science reviews available

NASA Astrophysics Data System (ADS)

Coincident with its triennial general assemblies, the International Union of Radio Science (URSI) publishes an international review of the most significant scientific developments over the previous 3 years in the nine subject areas covered by URSI's commissions. To produce this review, international editors distill reviews from each member country of national scientific developments. For those scientists who wish to know more details about the significant scientific developments in radio science in the United Kingdom from 1981 to 1984, the British National Committee for Radio Science has made its reviews available.Unless otherwise noted, the following surveys are available from the Royal Society, 6 Carlton House Terrace, London SW1Y 5AG, Attention: C.R. Argent.

Current Developments in Communications Law in the United States

ERIC Educational Resources Information Center

Hadl, Robert D.

1973-01-01

Article reviews some of the major developments in communications law in the United States in the past year (1972). Significant events are covered in the areas of cable television, television programming and domestic satelites. (Author)

Control strategies for effective robot assisted gait rehabilitation: the state of art and future prospects.

PubMed

Cao, Jinghui; Xie, Sheng Quan; Das, Raj; Zhu, Guo L

2014-12-01

A large number of gait rehabilitation robots, together with a variety of control strategies, have been developed and evaluated during the last decade. Initially, control strategies applied to rehabilitation robots were adapted from those applied to traditional industrial robots. However, these strategies cannot optimise effectiveness of gait rehabilitation. As a result, researchers have been investigating control strategies tailored for the needs of rehabilitation. Among these control strategies, assisted-as-needed (AAN) control is one of the most popular research topics in this field. AAN training strategies have gained the theoretical and practical evidence based backup from motor learning principles and clinical studies. Various approaches to AAN training have been proposed and investigated by research groups all around the world. This article presents a review on control algorithms of gait rehabilitation robots to summarise related knowledge and investigate potential trends of development. There are existing review papers on control strategies of rehabilitation robots. The review by Marchal-Crespo and Reinkensmeyer (2009) had a broad cover of control strategies of all kinds of rehabilitation robots. Hussain et al. (2011) had specifically focused on treadmill gait training robots and covered a limited number of control implementations on them. This review article encompasses more detailed information on control strategies for robot assisted gait rehabilitation, but is not limited to treadmill based training. It also investigates the potential to further develop assist-as-needed gait training based on assessments of patients' ability. In this paper, control strategies are generally divided into the trajectory tracking control and AAN control. The review covers these two basic categories, as well as other control algorithm and technologies derived from them, such as biofeedback control. Assessments on human gait ability are also included to investigate how to further develop implementations based on assist-as-needed concept. For the consideration of effectiveness, clinical studies on robotic gait rehabilitation are reviewed and analysed from the viewpoint of control algorithm. Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2014-2016).

PubMed

Breadmore, Michael C; Wuethrich, Alain; Li, Feng; Phung, Sui Ching; Kalsoom, Umme; Cabot, Joan M; Tehranirokh, Masoomeh; Shallan, Aliaa I; Abdul Keyon, Aemi S; See, Hong Heng; Dawod, Mohamed; Quirino, Joselito P

2017-01-01

One of the most cited limitations of capillary (and microchip) electrophoresis is the poor sensitivity. This review continues to update this series of biennial reviews, first published in Electrophoresis in 2007, on developments in the field of on-line/in-line concentration methods in capillaries and microchips, covering the period July 2014-June 2016. It includes developments in the field of stacking, covering all methods from field amplified sample stacking and large volume sample stacking, through to isotachophoresis, dynamic pH junction, and sweeping. Attention is also given to on-line or in-line extraction methods that have been used for electrophoresis. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Review of Land Use and Land Cover Change research progress

NASA Astrophysics Data System (ADS)

Chang, Yue; Hou, Kang; Li, Xuxiang; Zhang, Yunwei; Chen, Pei

2018-02-01

Land Use and Land Cover Change (LUCC) can reflect the pattern of human land use in a region, and plays an important role in space soil and water conservation. The study on the change of land use patterns in the world is of great significance to cope with global climate change and sustainable development. This paper reviews the main research progress of LUCC at home and abroad, and suggests that land use change has been shifted from land use planning and management to land use change impact and driving factors. The development of remote sensing technology provides the basis and data for LUCC with dynamic monitoring and quantitative analysis. However, there is no uniform standard for land use classification at present, which brings a lot of inconvenience to the collection and analysis of land cover data. Globeland30 is an important milestone contribution to the study of international LUCC system. More attention should be paid to the accuracy and results contrasting test of land use classification obtained by remote sensing technology.

34 CFR 668.145 - Test approval procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... possess appropriate advanced degrees and experience in test development or psychometric research, to... quantitative domains, the Secretary reviews only those subtests covering verbal and quantitative domains...

76 FR 29011 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Fire...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-19

... for OMB Review; Comment Request; Fire Protection in Shipyard Employment ACTION: Notice. SUMMARY: The... information collection request (ICR) titled, ``Fire Protection in Shipyard Employment,'' to the Office of... Fire Protection in Shipyard Employment Standard makes it mandatory for a covered employer to develop a...

Child Health Assessment; Part I: A Literature Review.

ERIC Educational Resources Information Center

Barnard, Kathryn E., Ed.; Douglas, Helen Bee, Ed.

Presented are 13 papers describing the Seattle Project and reviewing the literature relevant to the project's purpose of developing and testing an assessment format to enable nurses to better identify health and developmental problems in children. Six papers pertaining to predictor variables cover the areas of prenatal and perinatal factors,…

42 CFR 121.10 - Reviews, evaluation, and enforcement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... RESOURCES DEVELOPMENT ORGAN PROCUREMENT AND TRANSPLANTATION NETWORK § 121.10 Reviews, evaluation, and... carry out her/his responsibilities under the Public Health Service Act and the Social Security Act. (b... noncompliance is with a policy designated by the Secretary as covered by section 1138 of the Social Security Act...

A Review of International Telecommunications Industry Issues, Structure, and Regulatory Problems.

ERIC Educational Resources Information Center

Cole, Jack E.; And Others

Industry structure studies prior to 1968 are briefly reviewed, and an overview of industrial and technological developments up to the present is provided through synopses of more recent studies. Areas covered include overseas telephone and record carriers; the creation of the Communications Satellite Corporation; the current regulatory and…

Hamiltonian methods: BRST, BFV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garcia, J. Antonio

2006-09-25

The range of applicability of Hamiltonian methods to gauge theories is very diverse and cover areas of research from phenomenology to mathematical physics. We review some of the areas developed in Mexico in the last decades. They cover the study of symplectic methods, BRST-BFV and BV approaches, Klauder projector program, and non perturbative technics used in the study of bound states in relativistic field theories.

Hamiltonian methods: BRST, BFV

NASA Astrophysics Data System (ADS)

García, J. Antonio

2006-09-01

The range of applicability of Hamiltonian methods to gauge theories is very diverse and cover areas of research from phenomenology to mathematical physics. We review some of the areas developed in México in the last decades. They cover the study of symplectic methods, BRST-BFV and BV approaches, Klauder projector program, and non perturbative technics used in the study of bound states in relativistic field theories.

Using System Architecture, Review Entry Criteria, and Standard Work Package Data to Enable Rapid Development of Integrated Master Schedules

DTIC Science & Technology

2016-03-01

ENTRY CRITERIA, AND STANDARD WORK PACKAGE DATA TO ENABLE RAPID DEVELOPMENT OF INTEGRATED MASTER SCHEDULES by Burton W. Porter Jr. March 2016...2. REPORT DATE March 2016 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE USING SYSTEM ARCHITECTURE, REVIEW ENTRY ... ENTRY CRITERIA, AND STANDARD WORK PACKAGE DATA TO ENABLE RAPID DEVELOPMENT OF INTEGRATED MASTER SCHEDULES Burton W. Porter Jr. Civilian

Checkpoint inhibitors in advanced melanoma: effect on the field of immunotherapy.

PubMed

O'reilly, Aine; Larkin, James

2017-07-01

The success of the immune checkpoint inhibitors in melanoma has reinvigorated the field of immunotherapy. Immune checkpoint inhibitors are now the standard of care in multiple cancer types including lung cancer, head and neck cancer, urothelial cancer and renal cell cancer. The field of immunotherapy is currently expanding rapidly and will be a focus of research and development for decades to come. Areas covered: This review covers the early development of immune checkpoint inhibitors and the changes that occurred in the drug development paradigm to facilitate the development of immunotherapy. The review will summarise the areas into which immune checkpoint inhibitors have been adopted and will review the data that supported this. Furthermore, we will discuss future developments in immunotherapy and the current landscape regarding maximising the potential of immunotherapy in clinical practice. Expert commentary: In the author's opinion, the potential of immunotherapy is vast. To date immune checkpoint inhibition has already delivered durable responses in a proportion of patients with cancer types which were previously universally lethal. The future of immunotherapy will rely upon the intelligent application of translational research to clinical practice, such that immunotherapy can be effective for a wider population and maintain its current growth.

Tech notes: Ongoing or planned hydro research, results of recent studies, and reviews of new books, publications, and software

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Ongoing or planned hydro research, results of recent studies, and reviews of new books, publications, and software are covered. This month`s Tech Notes include: (1) a study linking development and reservoir silting in El Salvador, (2) publication of a guide for small hydro operatos, and (3) publication of a text outlining the development of hydroelectric power in Russia.

Computational Fluid Dynamics: Past, Present, And Future

NASA Technical Reports Server (NTRS)

Kutler, Paul

1988-01-01

Paper reviews development of computational fluid dynamics and explores future prospects of technology. Report covers such topics as computer technology, turbulence, development of solution methodology, developemnt of algorithms, definition of flow geometries, generation of computational grids, and pre- and post-data processing.

Developments in mycotoxin analysis: an update for 2016-2017

USDA-ARS?s Scientific Manuscript database

This review summarizes developments in the determination of mycotoxins over a period between mid-2016 and mid-2017. Analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone are covered in individual sections. Adv...

Developments in mycotoxin analysis: an update for 2015-2016

USDA-ARS?s Scientific Manuscript database

This review summarises developments in the determination of mycotoxins over a period between mid-2015 and mid-2016. Analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes, and zearalenone are covered in individual sections. Ad...

Developments in mycotoxin analysis: an update for 2010 - 2011

USDA-ARS?s Scientific Manuscript database

This review highlights developments in mycotoxin analysis and sampling over a period between mid-2010 and mid-2011. It covers the major mycotoxins aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. Analytical methods for mycotoxins conti...

Developments in mycotoxin analysis: an update for 2009 - 2010

USDA-ARS?s Scientific Manuscript database

This review highlights developments in mycotoxin analysis and sampling over a period between mid-2009 and mid-2010. It covers the major mycotoxins aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. New and improved methods for mycotoxins...

2006 NASA Seal/Secondary Air System Workshop; Volume 1

NASA Technical Reports Server (NTRS)

Steinetz, Bruce, M. (Editor); Hendricks, Robert C. (Editor); Delgado, Irebert (Editor)

2007-01-01

The 2006 NASA Seal/Secondary Air System workshop covered the following topics: (i) Overview of NASA s new Exploration Initiative program aimed at exploring the Moon, Mars, and beyond; (ii) Overview of NASA s new fundamental aeronautics technology project; (iii) Overview of NASA Glenn Research Center s seal project aimed at developing advanced seals for NASA s turbomachinery, space, and reentry vehicle needs; (iv) Reviews of NASA prime contractor, vendor, and university advanced sealing concepts including tip clearance control, test results, experimental facilities, and numerical predictions; and (v) Reviews of material development programs relevant to advanced seals development. Turbine engine studies have shown that reducing seal leakages as well as high-pressure turbine (HPT) blade tip clearances will reduce fuel burn, lower emissions, retain exhaust gas temperature margin, and increase range. Several organizations presented development efforts aimed at developing faster clearance control systems and associated technology to meet future engine needs. The workshop also covered several programs NASA is funding to develop technologies for the Exploration Initiative and advanced reusable space vehicle technologies. NASA plans on developing an advanced docking and berthing system that would permit any vehicle to dock to any on-orbit station or vehicle. Seal technical challenges (including space environments, temperature variation, and seal-on-seal operation) as well as plans to develop the necessary "androgynous" seal technologies were reviewed. Researchers also reviewed seal technologies employed by the Apollo command module that serve as an excellent basis for seals for NASA s new Crew Exploration Vehicle (CEV).

A Review of Guidelines on Home Drug Testing Websites for Parents

PubMed Central

Washio, Yukiko; Fairfax-Columbo, Jaymes; Ball, Emily; Cassey, Heather; Arria, Amelia M.; Bresani, Elena; Curtis, Brenda L.; Kirby, Kimberly C.

2014-01-01

Purpose To update and extend prior work reviewing websites that discuss home drug testing for parents and assess the quality of information that the websites provide to assist them to decide when and how to use home drug testing. Methods We conducted a world-wide web search that identified eight websites providing information for parents on home drug testing. We assessed the information on the sites using checklist developed with field experts in adolescent substance abuse and psychosocial interventions that focus on urine testing. Results None of the websites covered all of items on the 24-item checklist, and only three covered at least half of the items (12, 14, and 21 items, respectively). The five remaining websites covered less than half the checklist items. The mean number of items covered by the websites was 11. Conclusions Among the websites that we reviewed, few provided thorough information to parents regarding empirically-supported strategies to effectively use drug testing to intervene on adolescent substance use. Furthermore, most websites did not provide thorough information regarding the risks and benefits to inform parents’ decision to use home drug testing. Empirical evidence regarding efficacy, benefits, risks, and limitations of home drug testing is needed. PMID:25026103

Genetics and Epigenetics of Eating Disorders

PubMed Central

Yilmaz, Zeynep; Hardaway, J. Andrew; Bulik, Cynthia M.

2015-01-01

Eating disorders (EDs) are serious psychiatric conditions influenced by biological, psychological, and sociocultural factors. A better understanding of the genetics of these complex traits and the development of more sophisticated molecular biology tools have advanced our understanding of the etiology of EDs. The aim of this review is to critically evaluate the literature on the genetic research conducted on three major EDs: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). We will first review the diagnostic criteria, clinical features, prevalence, and prognosis of AN, BN, and BED, followed by a review of family, twin, and adoption studies. We then review the history of genetic studies of EDs covering linkage analysis, candidate gene association studies, genome-wide association studies, and the study of rare variants in EDs. Our review also incorporates a translational perspective by covering animal models of ED-related phenotypes. Finally, we review the nascent field of epigenetics of EDs and a look forward to future directions for ED genetic research. PMID:27013903

Policy Framework for Covering Preventive Services Without Cost Sharing: Saving Lives and Saving Money?

PubMed

Chen, Stephanie C; Pearson, Steven D

2016-08-01

The US Affordable Care Act mandates that private insurers cover a list of preventive services without cost sharing. The list is determined by 4 expert committees that evaluate the overall health effect of preventive services. We analyzed the process by which the expert committees develop their recommendations. Each committee uses different criteria to evaluate preventive services and none of the committees consider cost systematically. We propose that the existing committees adopt consistent evidence review methodologies and expand the scope of preventive services reviewed and that a separate advisory committee be established to integrate economic considerations into the final selection of free preventive services. The comprehensive framework and associated criteria are intended to help policy makers in the future develop a more evidence-based, consistent, and ethically sound approach.

Anatomy and development of the meninges: implications for subdural collections and CSF circulation.

PubMed

Mack, Julie; Squier, Waney; Eastman, James T

2009-03-01

The dura is traditionally viewed as a supportive fibrous covering of the brain containing the dural venous sinuses but otherwise devoid of vessels and lacking any specific function. However, review of the embryology and anatomy reveals the dura to be a complex, vascularized and innervated structure, not a simple fibrous covering. The dura contains an inner vascular plexus that is larger in the infant than in the adult, and this plexus likely plays a role in CSF absorption. This role could be particularly important in the infant whose arachnoid granulations are not completely developed. Although subdural hemorrhage is frequently traumatic, there are nontraumatic conditions associated with subdural hemorrhage, and the inner dural plexus is a likely source of bleeding in these nontraumatic circumstances. This review outlines the development and age-specific vascularity of the dura and offers an alternative perspective on the role of the dura in homeostasis of the central nervous system.

Aircraft Electrical Repairman Technician, 2-2. Military Curriculum Materials for Vocational and Technical Education.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

These military-developed curriculum materials consist of a volume of text information; a student workbook containing objectives, reading assignments, chapter review exercises, and answers; a volume review exercise; and two illustration booklets for use with the student exercises. Covered in the course are the following topics: use and maintenance…

Walter J. Ong's Perspectives on Rhetoric.

ERIC Educational Resources Information Center

Palmeri, Anthony

In order to demonstrate Walton J. Ong's continuing relevance to the field of rhetorical theory, a review of his intellectual contributions and development is conducted in three stages, covering not only Ong's books and major articles but also his Jesuit educational history and his reviews of other theorists. In the first period (1939-1950), Ong's…

Developments in mycotoxin analysis: an update for 2011-2012

USDA-ARS?s Scientific Manuscript database

This review highlights developments in mycotoxin analysis and sampling over a period between mid-2011 and mid-2012. It covers the major mycotoxins aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. A section on mycotoxins in botanicals a...

Annotated Bibliography of Rail Transit Safety, 1975-1980, with Emphasis on Safety Research and Development.

DOT National Transportation Integrated Search

1981-09-01

The bibliography provides a comprehensive review of published literature concerning rail transit safety and includes 186 annotated entries. The report covers domestic and foreign material on rail transit safety and related safety research and develop...

Developments in mycotoxin analysis: an update for 2012 – 2013

USDA-ARS?s Scientific Manuscript database

This review highlights developments in mycotoxin analysis and sampling over a period between mid-2012 and mid-2013. It covers the major mycotoxins: aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. A wide range of analytical methods for...

Typical and atypical brain development: a review of neuroimaging studies

PubMed Central

Dennis, Emily L.; Thompson, Paul M.

2013-01-01

In the course of development, the brain undergoes a remarkable process of restructuring as it adapts to the environment and becomes more efficient in processing information. A variety of brain imaging methods can be used to probe how anatomy, connectivity, and function change in the developing brain. Here we review recent discoveries regarding these brain changes in both typically developing individuals and individuals with neurodevelopmental disorders. We begin with typical development, summarizing research on changes in regional brain volume and tissue density, cortical thickness, white matter integrity, and functional connectivity. Space limits preclude the coverage of all neurodevelopmental disorders; instead, we cover a representative selection of studies examining neural correlates of autism, attention deficit/hyperactivity disorder, Fragile X, 22q11.2 deletion syndrome, Williams syndrome, Down syndrome, and Turner syndrome. Where possible, we focus on studies that identify an age by diagnosis interaction, suggesting an altered developmental trajectory. The studies we review generally cover the developmental period from infancy to early adulthood. Great progress has been made over the last 20 years in mapping how the brain matures with MR technology. With ever-improving technology, we expect this progress to accelerate, offering a deeper understanding of brain development, and more effective interventions for neurodevelopmental disorders. PMID:24174907

Typical and atypical brain development: a review of neuroimaging studies.

PubMed

Dennis, Emily L; Thompson, Paul M

2013-09-01

In the course of development, the brain undergoes a remarkable process of restructuring as it adapts to the environment and becomes more efficient in processing information. A variety of brain imaging methods can be used to probe how anatomy, connectivity, and function change in the developing brain. Here we review recent discoveries regarding these brain changes in both typically developing individuals and individuals with neurodevelopmental disorders. We begin with typical development, summarizing research on changes in regional brain volume and tissue density, cortical thickness, white matter integrity, and functional connectivity. Space limits preclude the coverage of all neurodevelopmental disorders; instead, we cover a representative selection of studies examining neural correlates of autism, attention deficit/hyperactivity disorder, Fragile X, 22q11.2 deletion syndrome, Williams syndrome, Down syndrome, and Turner syndrome. Where possible, we focus on studies that identify an age by diagnosis interaction, suggesting an altered developmental trajectory. The studies we review generally cover the developmental period from infancy to early adulthood. Great progress has been made over the last 20 years in mapping how the brain matures with MR technology. With ever-improving technology, we expect this progress to accelerate, offering a deeper understanding of brain development, and more effective interventions for neurodevelopmental disorders.

Tech notes: Ongoing or planned hydro research, results of recent studies, and reviews of new books, publications, and software

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Ongoing or planned hydro research, results of recent studies, and reviews of new books, publications, and software. Items covered this month include: (1) a recommendation that dam designers give more consideration to earthquake resistance, (2) the development of a new wave rotor design, (3) the development of a small hydro database in China, and (4) an ICOLD bulletin on the optimization of constuction costs.

Leveling the Playing Field: China’s Development of Advanced Energy Weapons

DTIC Science & Technology

2012-05-02

02-05-2012 2. REPORT TYPE Master of Military Studies Research Paper 3. DATES COVERED (From - To) September 2011 - April 2012 5a. CONTRACT NUMBER...weapons in a surprise attack scenario to counter superior U.S. capabilities and technology. This paper will update and review current and developing...utilizing these weapons in a surprise attack scenario to counter superior U.S. capabilities and technology. This paper will update and review current

Post-harvest entomology research in the United States Department of Agriculture-Agricultural Research Service.

PubMed

Throne, James E; Hallman, Guy J; Johnson, Judy A; Follett, Peter A

2003-01-01

This is a review of current post-harvest entomology research conducted by the Agricultural Research Service, the research branch of the US Department of Agriculture. The review covers both durable and perishable commodities. Research on biochemistry, genetics, physiology, monitoring and control of insects infesting stored grain, dried fruits and nuts, and processed commodities is reviewed. Research on development of quarantine treatments, particularly for fruit flies, is also reviewed, including research on thermal and irradiation treatments and a discussion of risk management for quarantine pests. Two areas of research are covered more extensively: a project to map the genome of the red flour beetle, Tribolium castaneum, and the use of near-infrared spectroscopy for detection of hidden infestations in grain, quantification of insect fragments in food, determination of quality in dried fruits, identification of insect species and age-grading insects. Future research directions are identified.

Development of the Home Learning Environment Profile.

ERIC Educational Resources Information Center

Heath, Robert W.; And Others

The development and validation of the Home Learning Environment Profile (HLEP) are outlined. The HLEP instrument was designed to assess successful preschool home educational programs for Hawaiian families. The instrument covers sociodemographic, cultural, and environmental factors of Hawaiian families. After an extensive review of published…

Space Station ECLSS Integration Analysis

NASA Technical Reports Server (NTRS)

1993-01-01

The Space Station Environmental Control and Life Support System (ECLSS) contract with NASA MSFC covered the time frame from 9 May 1985 to 31 Dec. 1992. The contract roughly covered the period of Space Station Freedom (SSF) development from early Phase B through Phase C/D Critical Design Review (CDR). During this time, McDonnell Douglas Aerospace-Huntsville (formerly McDonnell Douglas Space Systems Company) performed an analytical support role to MSFC for the development of analytical math models and engineering trade studies related to the design of the ECLSS for the SSF.

Biological evaluation of benzosuberones.

PubMed

Behbehani, Haider; Dawood, Kamal M; Farghaly, Thoraya A

2018-01-01

Several natural products containing benzosuberone moiety are clinically reported as anti-tumor agents. Furthermore, several synthetic benzosuberones cited in this review exhibited wide range of theraputic activities such as bacteriostatic, anti-inflammatory, antidepressants and anti-tumor activities. Our recent review provides an overview of the different methods to synthesize the benzosuberones and their extensive biological activities. Areas covered: Thirty-two patents among 130 references are cited in this review that covered the recent inhibitory activities of the benzosuberone scaffolds and their broad area of biological applications up to the first quarter of 2017. The areas covered included anti-inflammatory, antimicrobial, antitumor, selective estrogen receptor, anti-obesity, beta-amyloid production, enzymes and HCV inhibitors in addition to anti-Alzheimer and anti-tuberculosis activities as well as several receptors antagonists. Expert opinion: It is important for medical and pharmaceutical researchers to prepare the first intensive review article concerning the highly biologically active benzosuberone derivatives where they are potent anti-inflammatory, immunosuppressive, antitumor activities and inhibitors of several enzymes. They are useful for treating abnormalities such as sleep disorders, eating disorders and reproductive disorders. Some of these compounds have potential as vascular disrupting agents to selectively target microvessels feeding tumors and some were potential leads for the development of promising therapeutic drugs.

Child Health and Human Development: An Overview and Strategy for a Five-Year Research Plan.

ERIC Educational Resources Information Center

National Inst. of Child Health and Human Development (NIH), Bethesda, MD.

The first five-year research plans developed by the National Institute of Child Health and Human Development (NICHD), covering fiscal years 1983-1987 and 10 program areas, are published in this volume. Present knowledge is reviewed and research opportunities are indicated in the areas of reproduction, fetal development, the birth process, the…

Theme Issue on Mass Communication.

ERIC Educational Resources Information Center

Anapol, Malthon M., Ed.

1978-01-01

Focusing on issues in mass communication, the six articles in this journal issue cover many facets and approaches to the topics. The first article offers a review of recent developments in the field and some comments about its future. The second article reviews feminism in comedies from the 1930s and in a current film, and the third analyzes the…

Application of Calibrated Peer Review (CPR) Writing Assignments to Enhance Experiments with an Environmental Chemistry Focus

ERIC Educational Resources Information Center

Margerum, Lawrence D.; Gulsrud, Maren; Manlapez, Ronald; Rebong, Rachelle; Love, Austin

2007-01-01

The browser-based software program, Calibrated Peer Review (CPR) developed by the Molecular Science Project enables instructors to create structured writing assignments in which students learn by writing and reading for content. Though the CPR project covers only one experiment in general chemistry, it might provide lab instructors with a method…

In-Service Workshop Model. Development Work, Volunteer Service and Project Review. Core Curriculum Resource Materials.

ERIC Educational Resources Information Center

Edwards, Dan

A model is provided for an inservice workshop to provide systematic project review, conduct individual volunteer support and problem solving, and conduct future work planning. Information on model use and general instructions are presented. Materials are provided for 12 sessions covering a 5-day period. The first session on climate setting and…

Roots and Research. Key Stage 3 English. Key Stage 3: National Strategy.

ERIC Educational Resources Information Center

Harrison, Colin

In 1998, Roger Beard of the University of Leeds wrote an account of the research underpinning the emerging National Literacy Strategy (NLS). Since Beard published his review, there have been developments both in terms of age groups covered and within the field of literacy research. This document attempts a fresh review of the relationship between…

A theoretical and experimental investigation of propeller performance methodologies

NASA Technical Reports Server (NTRS)

Korkan, K. D.; Gregorek, G. M.; Mikkelson, D. C.

1980-01-01

This paper briefly covers aspects related to propeller performance by means of a review of propeller methodologies; presentation of wind tunnel propeller performance data taken in the NASA Lewis Research Center 10 x 10 wind tunnel; discussion of the predominent limitations of existing propeller performance methodologies; and a brief review of airfoil developments appropriate for propeller applications.

New Markets for Meeting Old Needs: U.S. Distance Education and Developing Countries.

ERIC Educational Resources Information Center

Carty, Winthrop

This paper analyzes the broad context and covers practical applications for delivering distance education in countries of the developing world. It begins by examining market trends in global higher education and continues by reviewing existing distance education activity in developing countries. This is followed by a discussion of the…

Biomarkers of Nutrition for Development—Iodine Review1234

PubMed Central

Rohner, Fabian; Zimmermann, Michael; Jooste, Pieter; Pandav, Chandrakant; Caldwell, Kathleen; Raghavan, Ramkripa; Raiten, Daniel J.

2014-01-01

The objective of the Biomarkers of Nutrition for Development (BOND) project is to provide state-of-the-art information and service with regard to selection, use, and interpretation of biomarkers of nutrient exposure, status, function, and effect. Specifically, the BOND project seeks to develop consensus on accurate assessment methodologies that are applicable to researchers (laboratory/clinical/surveillance), clinicians, programmers, and policy makers (data consumers). The BOND project is also intended to develop targeted research agendas to support the discovery and development of biomarkers through improved understanding of nutrient biology within relevant biologic systems. In phase I of the BOND project, 6 nutrients (iodine, vitamin A, iron, zinc, folate, and vitamin B-12) were selected for their high public health importance because they typify the challenges faced by users in the selection, use, and interpretation of biomarkers. For each nutrient, an expert panel was constituted and charged with the development of a comprehensive review covering the respective nutrient’s biology, existing biomarkers, and specific issues of use with particular reference to the needs of the individual user groups. In addition to the publication of these reviews, materials from each will be extracted to support the BOND interactive Web site (http://www.nichd.nih.gov/global_nutrition/programs/bond/pages/index.aspx). This review represents the first in the series of reviews and covers all relevant aspects of iodine biology and biomarkers. The article is organized to provide the reader with a full appreciation of iodine’s background history as a public health issue, its biology, and an overview of available biomarkers and specific considerations for the use and interpretation of iodine biomarkers across a range of clinical and population-based uses. The review also includes a detailed research agenda to address priority gaps in our understanding of iodine biology and assessment. PMID:24966410

Development of a solar-powered residential air conditioner. Program review

NASA Technical Reports Server (NTRS)

1975-01-01

Progress in the effort to develop a residential solar-powered air conditioning system is reported. The topics covered include the objectives, scope and status of the program. The results of state-of-art, design, and economic studies and component and system data are also presented.

A review of guidelines on home drug testing web sites for parents.

PubMed

Washio, Yukiko; Fairfax-Columbo, Jaymes; Ball, Emily; Cassey, Heather; Arria, Amelia M; Bresani, Elena; Curtis, Brenda L; Kirby, Kimberly C

2014-01-01

To update and extend prior work reviewing Web sites that discuss home drug testing for parents, and assess the quality of information that the Web sites provide, to assist them in deciding when and how to use home drug testing. We conducted a worldwide Web search that identified 8 Web sites providing information for parents on home drug testing. We assessed the information on the sites using a checklist developed with field experts in adolescent substance abuse and psychosocial interventions that focus on urine testing. None of the Web sites covered all the items on the 24-item checklist, and only 3 covered at least half of the items (12, 14, and 21 items, respectively). The remaining 5 Web sites covered less than half of the checklist items. The mean number of items covered by the Web sites was 11. Among the Web sites that we reviewed, few provided thorough information to parents regarding empirically supported strategies to effectively use drug testing to intervene on adolescent substance use. Furthermore, most Web sites did not provide thorough information regarding the risks and benefits to inform parents' decision to use home drug testing. Empirical evidence regarding efficacy, benefits, risks, and limitations of home drug testing is needed.

Recent Developments and Applications of the MMPBSA Method

PubMed Central

Wang, Changhao; Greene, D'Artagnan; Xiao, Li; Qi, Ruxi; Luo, Ray

2018-01-01

The Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) approach has been widely applied as an efficient and reliable free energy simulation method to model molecular recognition, such as for protein-ligand binding interactions. In this review, we focus on recent developments and applications of the MMPBSA method. The methodology review covers solvation terms, the entropy term, extensions to membrane proteins and high-speed screening, and new automation toolkits. Recent applications in various important biomedical and chemical fields are also reviewed. We conclude with a few future directions aimed at making MMPBSA a more robust and efficient method. PMID:29367919

Fabrication and Properties of Carbon Fibers

PubMed Central

Huang, Xiaosong

2009-01-01

This paper reviews the research and development activities conducted over the past few decades on carbon fibers. The two most important precursors in the carbon fiber industry are polyacrylonitrile (PAN) and mesophase pitch (MP). The structure and composition of the precursor affect the properties of the resultant carbon fibers significantly. Although the essential processes for carbon fiber production are similar, different precursors require different processing conditions in order to achieve improved performance. The research efforts on process optimization are discussed in this review. The review also attempts to cover the research on other precursor materials developed mainly for the purpose of cost reduction.

Review of Tm and Ho Materials; Spectroscopy and Lasers

NASA Technical Reports Server (NTRS)

Walsh, Brian M.

2008-01-01

A review of Tm and Ho materials is presented, covering some fundamental aspects on the spectroscopy and laser dynamics in both single and co-doped systems. Following an introduction to 2- m lasers, applications and historical development, the physics of quasi-four level lasers, energy transfer and modeling are discussed in some detail. Recent developments in using Tm lasers to pump Ho lasers are discussed, and seen to offer some advantages over conventional Tm:Ho lasers. This article is not intended as a complete review, but as a primer for introducing concepts and a resource for further study.

INTRACELLULAR SIGNALING AND DEVELOPMENTAL NEUROTOXICITY.

EPA Science Inventory

A book chapter in ?Molecular Toxicology: Transcriptional Targets? reviewed the role of intracellular signaling in the developmental neurotoxicity of environmental chemicals. This chapter covered a number of aspects including the development of the nervous system, role of intrace...

The Oxford English Dictionary: A Brief History.

ERIC Educational Resources Information Center

Fritze, Ronald H.

1989-01-01

Reviews the development of English dictionaries in general and the Oxford English Dictionary (OED) in particular. The discussion covers the decision by the Philological Society to create the dictionary, the principles that guided its development, the involvement of James Augustus Henry Murray, the magnitude and progress of the project, and the…

Basic Science Training Program.

ERIC Educational Resources Information Center

Brummel, Clete

These six learning modules were developed for Lake Michigan College's Basic Science Training Program, a workshop to develop good study skills while reviewing basic science. The first module, which was designed to provide students with the necessary skills to study efficiently, covers the following topics: time management; an overview of a study…

The U. S. Department of Energy SARP review training program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mauck, C.J.

1988-01-01

In support of its radioactive material packaging certification program, the U.S. Department of Energy (DOE) has established a special training workshop. The purpose of the two-week workshop is to develop skills in reviewing Safety Analysis Reports for Packagings (SARPs) and performing confirmatory analyses. The workshop, conducted by the Lawrence Livermore National Laboratory (LLNL) for DOE, is divided into two parts: methods of review and methods of analysis. The sessions covering methods of review are based on the DOE document, ''Packaging Review Guide for Reviewing Safety Analysis Reports for Packagings'' (PRG). The sessions cover relevant DOE Orders and all areas ofmore » review in the applicable Nuclear Regulatory Commission (NRC) Regulatory Guides. The technical areas addressed include structural and thermal behavior, materials, shielding, criticality, and containment. The course sessions on methods of analysis provide hands-on experience in the use of calculational methods and codes for reviewing SARPs. Analytical techniques and computer codes are discussed and sample problems are worked. Homework is assigned each night and over the included weekend; at the conclusion, a comprehensive take-home examination is given requiring six to ten hours to complete.« less

Boundary-fitted coordinate systems for numerical solution of partial differential equations - A review

NASA Technical Reports Server (NTRS)

Thompson, J. F.; Warsi, Z. U. A.; Mastin, C. W.

1982-01-01

A comprehensive review of methods of numerically generating curvilinear coordinate systems with coordinate lines coincident with all boundary segments is given. Some general mathematical framework and error analysis common to such coordinate systems is also included. The general categories of generating systems are those based on conformal mapping, orthogonal systems, nearly orthogonal systems, systems produced as the solution of elliptic and hyperbolic partial differential equations, and systems generated algebraically by interpolation among the boundaries. Also covered are the control of coordinate line spacing by functions embedded in the partial differential operators of the generating system and by subsequent stretching transformation. Dynamically adaptive coordinate systems, coupled with the physical solution, and time-dependent systems that follow moving boundaries are treated. References reporting experience using such coordinate systems are reviewed as well as those covering the system development.

78 FR 19148 - Shielding and Radiation Protection Review Effort and Licensing Conditions for Dry Storage...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-29

... learned and to address emergent issues not covered in SFST Standard Review Plans (SRPs). In this way, the... a formal SRP revision. The NRC has developed draft SFST-ISG-26A, Revision 0 to (1) enhance the... implementation of such guidance in the context of applications does not result in backfitting or non-compliance...

Developments in Business Gaming: A Review of the Past 40 Years

ERIC Educational Resources Information Center

Faria, A. J.; Hutchinson, David; Wellington, William J.; Gold, Steven

2009-01-01

This article examines developments in business simulation gaming during the past 40 years. Covered in this article are a brief history of business games, the changing technology employed in the development and use of business games, changes in why business games are adopted and used, changes in how business games are administered, and the current…

Maritime Math Review. The Port of Baltimore Workplace Skills Development Project.

ERIC Educational Resources Information Center

Janiszewski, Kathryn; Permut, Cathy

This set of learning modules was developed during a project to deliver workplace literacy instruction to individuals employed in the more than 50 businesses related to the activities of the Port of Baltimore. It is intended to help employees of port businesses develop basic math skills. The following topics are covered in the individual modules:…

Nicotinic acetylcholine receptor ligands; a patent review (2006-2011)

PubMed Central

Gündisch, Daniela; Eibl, Christoph

2012-01-01

Introduction Nicotinic acetylcholine receptors (nAChRs), pentameric ligand-gated cation channels, are potential targets for the development of therapeutics for a variety of disease states. Areas covered This article is reviewing recent advances in the development of small molecule ligands for diverse nAChR subtypes and is a continuation of an earlier review in this journal. Expert opinion The development of nAChR ligands with preference for α4β2 or α7 subtypes for the treatment of CNS disorders are in the most advanced developmental stage. In addition, there is a fast growing interest to generate so-called PAMs, positive allosteric modulators, to influence the channels’ functionalities. PMID:22098319

Gas Chromatography.

ERIC Educational Resources Information Center

Karasek, Francis W.; And Others

1984-01-01

This review covers fundamental developments in gas chromatography during 1982 and 1983. Literature is considered under these headings: columns; liguid phases; solid supports; sorption processes and solvents; open tubular column gas chromatography; instrumentation; high-resolution columns and applications; other techniques; qualitative and…

Assessment of lightweight mobile nuclear power systems. [for airborne vehicles

NASA Technical Reports Server (NTRS)

Anderson, J. L.; Rom, F. E.

1973-01-01

A review was made of lightweight mobile nuclear power systems (LMNPS). Data cover technical feasibility studies of LMNPS and airborne vehicles, mission studies, and non-technical conditions that are required to develop and use LMNPS.

Pavement design guide : Louisiana Department of Transportation.

DOT National Transportation Integrated Search

2013-01-01

The purpose of this guide is to provide a comprehensive review of pavement design for the Louisiana Department of Transportation and Development (DOTD), consultants, and contractors. This guide will cover the thickness design of new, reconstructed, a...

New Cork-Based Materials and Applications.

PubMed

Gil, Luís

2015-02-10

This review work is an update of a previous work reporting the new cork based materials and new applications of cork based materials. Cork is a material which has been used for multiple applications. The most known uses of cork are in stoppers (natural and agglomerated cork) for alcoholic beverages, classic floor covering with composite cork tiles (made by the binding of cork particles with different binders), and thermal/acoustic/vibration insulation with expanded corkboard in buildings and some other industrial fields. Many recent developments have been made leading to new cork based materials. Most of these newly developed cork materials are not yet on the market, but they represent new possibilities for engineers, architects, designers and other professionals which must be known and considered, potentially leading to their industrialization. This paper is a review covering the last five years of innovative cork materials and applications also mentioning previous work not reported before.

New Cork-Based Materials and Applications

PubMed Central

Gil, Luís

2015-01-01

This review work is an update of a previous work reporting the new cork based materials and new applications of cork based materials. Cork is a material which has been used for multiple applications. The most known uses of cork are in stoppers (natural and agglomerated cork) for alcoholic beverages, classic floor covering with composite cork tiles (made by the binding of cork particles with different binders), and thermal/acoustic/vibration insulation with expanded corkboard in buildings and some other industrial fields. Many recent developments have been made leading to new cork based materials. Most of these newly developed cork materials are not yet on the market, but they represent new possibilities for engineers, architects, designers and other professionals which must be known and considered, potentially leading to their industrialization. This paper is a review covering the last five years of innovative cork materials and applications also mentioning previous work not reported before. PMID:28787962

Land cover mapping for development planning in Eastern and Southern Africa

NASA Astrophysics Data System (ADS)

Oduor, P.; Flores Cordova, A. I.; Wakhayanga, J. A.; Kiema, J.; Farah, H.; Mugo, R. M.; Wahome, A.; Limaye, A. S.; Irwin, D.

2016-12-01

Africa continues to experience intensification of land use, driven by competition for resources and a growing population. Land cover maps are some of the fundamental datasets required by numerous stakeholders to inform a number of development decisions. For instance, they can be integrated with other datasets to create value added products such as vulnerability impact assessment maps, and natural capital accounting products. In addition, land cover maps are used as inputs into Greenhouse Gas (GHG) inventories to inform the Agriculture, Forestry and other Land Use (AFOLU) sector. However, the processes and methodologies of creating land cover maps consistent with international and national land cover classification schemes can be challenging, especially in developing countries where skills, hardware and software resources can be limiting. To meet this need, SERVIR Eastern and Southern Africa developed methodologies and stakeholder engagement processes that led to a successful initiative in which land cover maps for 9 countries (Malawi, Rwanda, Namibia, Botswana, Lesotho, Ethiopia, Uganda, Zambia and Tanzania) were developed, using 2 major classification schemes. The first sets of maps were developed based on an internationally acceptable classification system, while the second sets of maps were based on a nationally defined classification system. The mapping process benefited from reviews from national experts and also from technical advisory groups. The maps have found diverse uses, among them the definition of the Forest Reference Levels in Zambia. In Ethiopia, the maps have been endorsed by the national mapping agency as part of national data. The data for Rwanda is being used to inform the Natural Capital Accounting process, through the WAVES program, a World Bank Initiative. This work illustrates the methodologies and stakeholder engagement processes that brought success to this land cover mapping initiative.

Electrostatic Surface Modifications to Improve Gene Delivery

PubMed Central

Shmueli, Ron B.; Anderson, Daniel G.

2010-01-01

Importance of the field Gene therapy has the potential to treat a wide variety of diseases including genetic diseases and cancer. Areas covered in this review This review introduces biomaterials used for gene delivery and then focuses on the use of electrostatic surface modifications to improve gene delivery materials. These modifications have been used to stabilize therapeutics in vivo, add cell-specific targeting ligands, and promote controlled release. Coatings of nanoparticles and microparticles as well as non-particulate surface coatings are covered in this review. Electrostatic principles are crucial for the development of multilayer delivery structures fabricated by the layer-by-layer method. What the reader will gain The reader will gain knowledge about the composition of biomaterials used for surface modifications and how these coatings and multilayers can be utilized to improve spatial control and efficiency of delivery. Examples are shown for the delivery of nucleic acids, including DNA and siRNA, to in vitro and in vivo systems. Take home message The versatile and powerful approach of electrostatic coatings and multilayers will lead to the development of enhanced gene therapies. PMID:20201712

Securing insurance protection against fraud and abuse liability.

PubMed

Callison, S

1999-07-01

Healthcare organizations concerned about corporate compliance need to review securing appropriate insurance coverage as part of their corporate compliance program. Provider organizations often mistakenly expect that their directors and officers liability (D&O), malpractice, or standard errors and omissions (E&O) insurance policies will cover the cost of Medicare fraud and abuse fines. The insurance industry has developed a specific billing E&O insurance product to cover providers that run afoul of government fraud and abuse statutes.

Proceedings: Fourth Parabolic Dish Solar Thermal Power Program Review

NASA Technical Reports Server (NTRS)

1983-01-01

The results of activities within the parabolic dish technology and applications development program are presented. Stirling, organic Rankine and Brayton module technologies, associated hardware and test results to date; concentrator development and progress; economic analyses; and international dish development activities are covered. Two panel discussions, concerning industry issues affecting solar thermal dish development and dish technology from a utility/user perspective, are also included.

Grazing and Rangeland Development for Livestock Production. A Handbook for Volunteers. Agriculture Technology for Developing Countries. Appropriate Technologies for Development. Reprint R-47.

ERIC Educational Resources Information Center

Sprague, Howard B.; And Others

This handbook, developed for training Peace Corps volunteers, reviews the basic principles that underlie sound grazing land management and indicates the application of these principles for livestock production in the tropics and subtropics. The handbook is made up of three technical series bulletins. The first bulletin covers management of…

Technology-Mediated Second Language Vocabulary Development: A Review of Trends in Research Methodology

ERIC Educational Resources Information Center

Elgort, Irina

2018-01-01

Technology-mediated vocabulary development (TMVD) in a second language (L2) covers a wide range of instructional and learning treatments, contexts, and technologies and is situated in a broader field of second language vocabulary learning. Vocabulary knowledge is a complex, multidimensional construct that has been interpreted and categorized in…

Indian Self-Determination and Education Reform Act of 1973

ERIC Educational Resources Information Center

Education Journal of the Institute for the Development of Indian Law, 1973

1973-01-01

The issue summarizes and reviews the Indian Self-Determination and Educational Reform Act of 1973 (S.1017), which was introduced into the Senate at the end of February. Sections cover how a bill becomes law and a summary of S.1017 (including Indians in public schools, professional development, and research and development). (KM)

Charter School Facilities: A Resource Guide on Development and Financing.

ERIC Educational Resources Information Center

Jakubowski, Lara

This manual provides information to help charter schools navigate the facility development process, including worksheets that can be customized to suit a particular school's needs. Sections cover how facility planning fits into business planning for charter schools, review a process for assessing a school's facility needs, and summarize how to…

Strategy and the Learning Organization: A Maturity Model for the Formation of Strategy

ERIC Educational Resources Information Center

Kenny, John

2006-01-01

Purpose: To develop a theoretical model for strategic change that links learning in an organization to the strategic process. Design/methodology/approach: The model was developed from a review of literature covering a range of areas including: management, strategic planning, psychology of learning and organizational learning. The process of…

Preschool Child Development: Implications for Investigation of Child Abuse Allegations.

ERIC Educational Resources Information Center

Sivan, Abigail B.

1991-01-01

This article reviews research on child development relevant to the question of the veracity of mistreatment allegations made by children ages two to five years. The article covers research on thought and language, memory and learning, fears, fantasy, play, and television's effects. It is concluded that preschoolers base their play on the reality…

New psychoactive substances: an overview on recent publications on their toxicodynamics and toxicokinetics.

PubMed

Meyer, Markus R

2016-10-01

This review article covers English-written and PubMed-listed review articles and original studies published between January 2015 and April 2016 dealing with the toxicodynamics and toxicokinetics of new psychoactive substances. Compounds covered include stimulants and entactogens, synthetic cannabinoids, tryptamines, NBOMes, phencyclidine-like drugs, benzodiazepines, and opioids. First, an overview and discussion is provided on timely review articles followed by an overview and discussion on recent original studies. Both sections are then concluded by an opinion on these latest developments. This review shows that the NPS market is still highly dynamic and that the data published on their toxicodynamics and toxicokinetics can hardly keep pace with the appearance of new entities. However, data available are very helpful to understand and predict how NPS may behave in severe intoxication. The currently best-documented parameter is the in vitro metabolism of NPS, a prerequisite to allow detection of NPS in biological matrices in cases of acute intoxications or chronic consumption. However, additional data such as their chronic toxicity are still lacking.

High performance N2O4/amine elements: Data dump covering. Task 1: Literature review

NASA Technical Reports Server (NTRS)

Hines, W. S.; Nurick, W. H.

1974-01-01

The phenomenon of reactive stream separation (RSS) in the N2O4/amine earth-storable propellant combinations is reviewed. Early theoretical models of RSS are presented, as are experimental combustion data under simulated rocket conditions. N2O4/amine combustion chemistry data is also provided. More recent work in the development of a comprehensive model is described.

Amino acids as promoieties in prodrug design and development.

PubMed

Vig, Balvinder S; Huttunen, Kristiina M; Laine, Krista; Rautio, Jarkko

2013-10-01

Prodrugs are biologically inactive agents that upon biotransformation in vivo result in active drug molecules. Since prodrugs might alter the tissue distribution, efficacy and the toxicity of the parent drug, prodrug design should be considered at the early stages of preclinical development. In this regard, natural and synthetic amino acids offer wide structural diversity and physicochemical properties. This review covers the use of amino acid prodrugs to improve poor solubility, poor permeability, sustained release, intravenous delivery, drug targeting, and metabolic stability of the parent drug. In addition, practical considerations and challenges associated with the development of amino acid prodrugs are also covered. Copyright © 2012 Elsevier B.V. All rights reserved.

RQ: 1960 to 1985.

ERIC Educational Resources Information Center

Krieger, Tillie

1985-01-01

Growth and changes in "RQ" (1960-1985) are examined and detailed in both text and tables (cover/size, pagination, editor, articles, advertisements, physical features, association interests, reviews, columns, government publications). Development of columns, government publication news, thematic articles, authors of "RQ"…

New developments in sampling and aggregation for remotely sensed surveys

NASA Technical Reports Server (NTRS)

Feiveson, A. H. (Principal Investigator)

1979-01-01

Sampling techniques used to construct large area crop estimates are briefly reviewed. Problem areas in sampling and aggregation are covered. The natural sampling strategy, two phase sampling, weighted aggregation, and multiyear estimation are among the topics discussed.

TU-D-201-02: Medical Physics Practices for Plan and Chart Review: Results of AAPM Task Group 275 Survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fong de los Santos, L; Dong, L; Greener, A

Purpose: AAPM Task Group (TG) 275 is charged with developing riskbased guidelines for plan and chart review clinical processes. As part of this work an AAPM-wide survey was conducted to gauge current practices. Methods: The survey consisted of 103 multiple-choice questions covering the following review processes for external beam including protons: 1) Initial Plan Check, 2) On-Treatment and 3) End-of-Treatment Chart Check. The survey was designed and validated by TG members with the goal of providing an efficient and easy response process. The survey, developed and deployed with the support of AAPM headquarters, was released to all AAPM members whomore » have self-reported as working in the radiation oncology field and it was kept open for 7 weeks. Results: There are an estimated 4700 eligible participants. At the time of writing, 962 completed surveys have been collected with an average completion time of 24 minutes. Participants are mainly from community hospitals (40%), academicaffiliated hospitals (31%) and free-standing clinics (18%). Among many other metrics covered on the survey, results so far indicate that manual review is an important component on the plan and chart review process (>90%) and that written procedures and checklists are widely used (>60%). However, the details of what is reviewed or checked are fairly heterogeneous among the sampled medical physics community. Conclusion: The data gathered from the survey gauging current practices will be used by TG 275 to develop benchmarks and recommendations for the type and extent of checks to perform effective physics plan and chart review processes.« less

Recent Developments in the Addition of Phosphinylidene-Containing Compounds to Unactivated Unsaturated Hydrocarbons: Phosphorus-Carbon Bond-Formation via Hydrophosphinylation and Related Processes

PubMed Central

Coudray, Laëtitia

2012-01-01

Summary The reactions of phosphinylidene-containing compounds with unactivated unsaturated hydrocarbons are reviewed. The review is organized by phosphorus-containing functional group types. Free-radical and metal-catalyzed additions of R1R2P(O)H to alkenes, alkynes, and related compounds, deliver functionalized organophosphorus compounds RP(O)R1R2, including H-phosphinates, phosphinates, tertiary phosphine oxides, and phosphonates. The review covers the literature up to February 2008. PMID:23308039

Floating drug delivery systems: a review.

PubMed

Arora, Shweta; Ali, Javed; Ahuja, Alka; Khar, Roop K; Baboota, Sanjula

2005-10-19

The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

Geothermal power development in Hawaii. Volume 1. Review and analysis

NASA Astrophysics Data System (ADS)

1982-06-01

The history of geothermal exploration in Hawaii is reviewed briefly. The nature and occurrences of geothermal resources are presented island by island. An overview of geothermal markets is presented. Other topics covered are: potential markets of the identified geothermal areas, well drilling technology, hydrothermal fluid transport, overland and submarine electrical transmission, community aspects of geothermal development, legal and policy issues associated with mineral and land ownership, logistics and infrastructure, legislation and permitting, land use controls, Regulation 8, public utilities commission, political climate and environment, state plans, county plans, geothermal development risks, and business planning guidelines.

Applications systems verification and transfer project. Volume 5: Operational applications of satellite snow-cover observations, northwest United States

NASA Technical Reports Server (NTRS)

Dillard, J. P.

1981-01-01

The study objective was to develop or modify methods in an operational framework that would allow incorporation of satellite derived snow cover observations for prediction of snowmelt derived runoff. Data were reviewed and verified for five basins in the Pacific Northwest. The data were analyzed for up to a 6-year period ending July 1978, and in all cases cover a low, average, and high snow cover/runoff year. Cloud cover is a major problem in these springtime runoff analyses and have hampered data collection for periods of up to 52 days. Tree cover and terrain are sufficiently dense and rugged to have caused problems. The interpretation of snowlines from satellite data was compared with conventional ground truth data and tested in operational streamflow forecasting models. When the satellite snow-covered area (SCA) data are incorporated in the SSARR (Streamflow Synthesis and Reservoir Regulation) model, there is a definite but minor improvement.

Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations.

PubMed

Srinivas, Nuggehally R

2006-05-01

The development of sound bioanalytical method(s) is of paramount importance during the process of drug discovery and development culminating in a marketing approval. Although the bioanalytical procedure(s) originally developed during the discovery stage may not necessarily be fit to support the drug development scenario, they may be suitably modified and validated, as deemed necessary. Several reviews have appeared over the years describing analytical approaches including various techniques, detection systems, automation tools that are available for an effective separation, enhanced selectivity and sensitivity for quantitation of many analytes. The intention of this review is to cover various key areas where analytical method development becomes necessary during different stages of drug discovery research and development process. The key areas covered in this article with relevant case studies include: (a) simultaneous assay for parent compound and metabolites that are purported to display pharmacological activity; (b) bioanalytical procedures for determination of multiple drugs in combating a disease; (c) analytical measurement of chirality aspects in the pharmacokinetics, metabolism and biotransformation investigations; (d) drug monitoring for therapeutic benefits and/or occupational hazard; (e) analysis of drugs from complex and/or less frequently used matrices; (f) analytical determination during in vitro experiments (metabolism and permeability related) and in situ intestinal perfusion experiments; (g) determination of a major metabolite as a surrogate for the parent molecule; (h) analytical approaches for universal determination of CYP450 probe substrates and metabolites; (i) analytical applicability to prodrug evaluations-simultaneous determination of prodrug, parent and metabolites; (j) quantitative determination of parent compound and/or phase II metabolite(s) via direct or indirect approaches; (k) applicability in analysis of multiple compounds in select disease areas and/or in clinically important drug-drug interaction studies. A tabular representation of select examples of analysis is provided covering areas of separation conditions, validation aspects and applicable conclusion. A limited discussion is provided on relevant aspects of the need for developing bioanalytical procedures for speedy drug discovery and development. Additionally, some key elements such as internal standard selection, likely issues of mass detection, matrix effect, chiral aspects etc. are provided for consideration during method development.

Overview of cancer vaccines

PubMed Central

Kudrin, Alex

2012-01-01

Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This is a review dedicated to determine major regulatory and developmental issues around cancer immunotherapeutics. A three pillar approach should be used in setting a development path: discovery platforms and sufficient pool of validated tumor antigens, product development strategy enabling to bring the product closer to the patient and clinical development strategy accounting for competitive landscape, treatment paradigm, technical and commercial risks. Regulatory framework existing around cancer vaccines in the EU, US, Japan and some developing countries is outlined. In addition, the review covers some specific issues on the design and conduct of clinical trials with cancer vaccines. PMID:22894970

Microgravity Combustion Research: 1999 Program and Results

NASA Technical Reports Server (NTRS)

Friedman, Robert (Editor); Gokoglu, Suleyman A. (Editor); Urban, David L. (Editor)

1999-01-01

The use of the microgravity environment of space to expand scientific knowledge and to enable the commercial development of space for enhancing the quality of life on Earth is particularly suitable to the field of combustion. This document reviews the current status of microgravity combustion research and derived information. It is the fourth in a series of timely surveys, all published as NASA Technical Memoranda, and it covers largely the period from 1995 to early 1999. The scope of the review covers three program areas: fundamental studies, applications to fire safety and other fields. and general measurements and diagnostics. The document also describes the opportunities for Principal Investigator participation through the NASA Research Announcement program and the NASA Glenn Research Center low-gravity facilities available to researchers.

Spaceflight induced changes in the human proteome.

PubMed

Kononikhin, Alexey S; Starodubtseva, Natalia L; Pastushkova, Lyudmila Kh; Kashirina, Daria N; Fedorchenko, Kristina Yu; Brhozovsky, Alexander G; Popov, Igor A; Larina, Irina M; Nikolaev, Evgeny N

2017-01-01

Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to minimize risks to astronauts. Areas covered: This review is a summary of literature searches from PubMed, NASA, Roskosmos and the authors' research experiences and opinions. The review covers the available proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based model experiments. Expert commentary: Overall, the authors believe that the present background, methodology and equipment improvements will enhance spaceflight safety and support accumulation of new knowledge on how organisms adapt to extreme conditions.

Membrane guanylate cyclase is a beautiful signal transduction machine: overview.

PubMed

Sharma, Rameshwar K

2010-01-01

This article is a sequel to the four earlier comprehensive reviews which covered the field of membrane guanylate cyclase from its origin to the year 2002 (Sharma in Mol Cell Biochem 230:3-30, 2002) and then to the year 2004 (Duda et al. in Peptides 26:969-984, 2005); and of the Ca(2+)-modulated membrane guanylate cyclase to the year 1997 (Pugh et al. in Biosci Rep 17:429-473, 1997) and then to 2004 (Sharma et al. in Curr Top Biochem Res 6:111-144, 2004). This article contains three parts. The first part is "Historical"; it is brief, general, and freely borrowed from the earlier reviews, covering the field from its origin to the year 2004 (Sharma in Mol Cell Biochem, 230:3-30, 2002; Duda et al. in Peptides 26:969-984, 2005). The second part focuses on the "Ca(2+)-modulated ROS-GC membrane guanylate cyclase subfamily". It is divided into two sections. Section "Historical" and covers the area from its inception to the year 2004. It is also freely borrowed from an earlier review (Sharma et al. in Curr Top Biochem Res 6:111-144, 2004). Section "Ca(2+)-modulated ROS-GC membrane guanylate cyclase subfamily" covers the area from the year 2004 to May 2009. The objective is to focus on the chronological development, recognize major contributions of the original investigators, correct misplaced facts, and project on the future trend of the field of mammalian membrane guanylate cyclase. The third portion covers the present status and concludes with future directions in the field.

Advances in the design of nanomaterial-based electrochemical affinity and enzymatic biosensors for metabolic biomarkers: A review.

PubMed

Farzin, Leila; Shamsipur, Mojtaba; Samandari, Leila; Sheibani, Shahab

2018-05-02

This review (with 340 refs) focuses on methods for specific and sensitive detection of metabolites for diagnostic purposes, with particular emphasis on electrochemical nanomaterial-based sensors. It also covers novel candidate metabolites as potential biomarkers for diseases such as neurodegenerative diseases, autism spectrum disorder and hepatitis. Following an introduction into the field of metabolic biomarkers, a first major section classifies electrochemical biosensors according to the bioreceptor type (enzymatic, immuno, apta and peptide based sensors). A next section covers applications of nanomaterials in electrochemical biosensing (with subsections on the classification of nanomaterials, electrochemical approaches for signal generation and amplification using nanomaterials, and on nanomaterials as tags). A next large sections treats candidate metabolic biomarkers for diagnosis of diseases (in the context with metabolomics), with subsections on biomarkers for neurodegenerative diseases, autism spectrum disorder and hepatitis. The Conclusion addresses current challenges and future perspectives. Graphical abstract This review focuses on the recent developments in electrochemical biosensors based on the use of nanomaterials for the detection of metabolic biomarkers. It covers the critical metabolites for some diseases such as neurodegenerative diseases, autism spectrum disorder and hepatitis.

[On necessity to modify biochemical methods for detecting organophosphorus componds in chemical weapons extinction objects (review of literature)].

PubMed

Prokofieva, D S; Shmurak, V I; Sadovnikov, S V; Gontcharov, N V

2015-01-01

The article covers problems of biochemical methods assessing organophosphorus toxic compounds in objects of chemical weapons extinction. The authors present results of works developing new, more specific and selective biochemical methods.

Fourth National Aeronautics and Space Administration Weather and Climate Program Science Review

NASA Technical Reports Server (NTRS)

Kreins, E. R. (Editor)

1979-01-01

The NASA Weather and Climate Program has two major thrusts. The first involves the development of experimental and prototype operational satellite systems, sensors, and space facilities for monitoring and understanding the atmosphere. The second thrust involves basic scientific investigation aimed at studying the physical and chemical processes which control weather and climate. This fourth science review concentrated on the scientific research rather than the hardware development aspect of the program. These proceedings contain 65 papers covering the three general areas: severe storms and local weather research, global weather, and climate.

Human Needs: A Literature Review and Cognitive Life Span Model

DTIC Science & Technology

1992-04-01

stages where crises are met, and, if favorably resolved, result in personality growth. Erikson’s psychosocial theory covers development from birth to...death. He describes eight major tasks or challenges people face as they undergo psychosocial development . Three of the eight stages of development ...the order that Erikson suggested. Several researchers (e.g., Rosenthal, Gurney, & Moore, 1981) have developed inventories that measure Erikson’s stages

Urban heat island effect: A systematic review of spatio-temporal factors, data, methods, and mitigation measures

NASA Astrophysics Data System (ADS)

Deilami, Kaveh; Kamruzzaman, Md.; Liu, Yan

2018-05-01

Despite research on urban heat island (UHI) effect has increased exponentially over the last few decades, a systematic review of factors contributing to UHI effect has scarcely been reported in the literature. This paper provides a systematic and overarching review of different spatial and temporal factors affecting the UHI effect. UHI is a phenomenon when urban areas experience a higher temperature than their surrounding non-urban areas and is considered as a critical factor contributing to global warming, heat related mortalities, and unpredictable climatic changes. Therefore, there is a pressing need to identify the spatio-temporal factors that contribute to (or mitigate) the UHI effect in order to develop a thorough understanding of their causal mechanism so that these are addressed through urban planning policies. This paper systematically identified 75 eligible studies on UHI effect and reviews the nature and type of satellite images used, the techniques applied to classify land cover/use changes, the models to assess the link between spatio-temporal factors and UHI effect, and the effects of these factors on UHI. The review results show that: a) 54% of the studies used Landsat TM images for modelling the UHI effect followed by Landsat ETM (34%), and MODIS (28%); b) land cover indices (46%), followed by supervised classification (17%) were the dominant methods to derive land cover/use changes associated with UHI effect; c) ordinary least square regression is the most commonly applied method (68%) to investigate the link between different spatio-temporal factors and the UHI effect followed by comparative analysis (33%); and d) the most common factors affecting the UHI effect as reported in the reviewed studies, include vegetation cover (44%), season (33%), built-up area (28%), day/night (25%), population density (14%), water body (12%) together with others. This research discusses the findings in policy terms and provides directions for future research.

Early Childhood Research & Practice: An Internet Journal on the Development, Care, and Education of Young Children, Spring 2000.

ERIC Educational Resources Information Center

Katz, Lilian G., Ed.; Rothenberg, Dianne, Ed.

2000-01-01

Early Childhood Research and Practice (ECRP), a peer-reviewed, Internet-only journal sponsored by the ERIC Clearinghouse on Elementary and Early Childhood Education (ERIC/EECE), covers topics related to the development, care, and education of children from birth to approximately age 8. ECRP emphasizes articles reporting on practice-related…

Early Childhood Research & Practice: An Internet Journal on the Development, Care, and Education of Young Children, Fall 1999.

ERIC Educational Resources Information Center

Katz, Lilian G., Ed.; Rothenberg, Dianne, Ed.

1999-01-01

Early Childhood Research & Practice (ECRP), a peer-reviewed, Internet-only journal sponsored by the ERIC Clearinghouse on Elementary and Early Childhood Education (ERIC/EECE), covers topics related to the development, care, and education of children from birth to approximately age 8. ECRP emphasizes articles reporting on practice-related…

Early Childhood Research & Practice: An Internet Journal on the Development, Care, and Education of Young Children, Fall 2002.

ERIC Educational Resources Information Center

Katz, Lilian G., Ed.; Rothenberg, Dianne, Ed.

2002-01-01

Early Childhood Research & Practice (ECRP), a peer-reviewed, Internet-only journal sponsored by the ERIC Clearinghouse on Elementary and Early Childhood Education (ERIC/EECE), covers topics related to the development, care, and education of children from birth to approximately age 8. The journal emphasizes articles reporting on…

A Review of Underground Coal Gasification Research and Development in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Camp, D. W.

An intense and productive period of research and development on underground coal gasification (UCG) took place in the United States from the mid-1970’s through the late 1980’s. It began with the translation and review of Soviet literature and ended with the Rocky Mountain 1 field test. This demonstrated the feasibility of newly-developed technologies that form the basis of many UCG projects around the world today. This period began with little domestic understanding of UCG and ended with an accurate observation-based conceptual model and a corresponding predictive multi-physics mathematical model of the process. The many accomplishments of this period form themore » main content of this report. This report also covers recent U.S. activities and accomplishments during the period 2004-2015, and touches briefly on the Bureau of Mines efforts between 1948 and 1963. Most of the activities were funded by the United States Department of Energy and its predecessors. While private/commercially-funded activities are reviewed here, the emphasis is on government-funded work. It has a much greater extent of publicly available reports and papers, and they generally contain much greater technical detail. Field tests were the marquis activities around which an integrated multi-faceted program was built. These are described in detail in Section 4. Highlights from modeling efforts are briefly covered, as the program was integrated and well-rounded, with field results informing models and vice-versa. The primary goal of this report is to review what has been learned about UCG from the U.S. experience in aggregate. This includes observations, conclusions, lessons-learned, phenomena understood, and technology developed. The latter sections of this report review these things.« less

Opportunities and progress.

PubMed

Litchfield, John H

2014-01-01

In this review, I cover my professional experiences in food science and technology and related areas of applied and industrial microbiology over the span of my career. It emphasizes opportunities and technological problems that I encountered together with my progress in follow-up development of products and processes.

Improving Student Safety.

ERIC Educational Resources Information Center

Dorn, Michael; Trump, Kenneth S.; Nichols, R. Leslie

2001-01-01

Presents the latest information on how schools can keep their students safe. Safety oriented actions discussed cover incident reporting and tracking, tactical site surveys, school safety and emergency operations planning, staff development efforts, and facility design. Explains the need to review and test specific prevention concepts and emergency…

Integrating Precalculus Review with the First Course in Calculus.

ERIC Educational Resources Information Center

Sevilla, Alicia; Somers, Kay

1993-01-01

Describes a course designed by Moravian College, Pennsylvania, to integrate precalculus topics as needed into a first calculus course. The textbook developed for the course covers the concepts of functions, Cartesian coordinates, limits, continuity, infinity, and the derivative. Examples are discussed. (MDH)

Wisconsin Fire Service Certification Program Procedures.

ERIC Educational Resources Information Center

Pribyl, Paul F.

These procedures for the Wisconsin Fire Service Certification Program provide professional qualification standards for three levels of fire fighter and four levels of fire service instructor. A section on program authority/operations covers program development, the credential review system, and revocation of certification. Requirements for…

Fun and games in reviewing neonatal emergency care.

PubMed

Gordon, D W; Brown, H N

1995-04-01

To develop a game-based review instrument for use by newborn caregivers in preparing for emergency situations. One hundred and one test questions covering pathophysiology, resuscitation, and medications were developed. The questions then underwent expert and peer review, psychometric testing for content validity and test-retest reliability, and a game trial. The needs of adult learners are different from those of other learners. The gaming format uses knowledge gained through experience and provides an avenue for validating knowledge and sharing experiences. This format has been found effective for review and reinforcement of facts. Twelve nurses participated in a trial game and completed a written evaluation using a Likert scale. The Neonatal Emergency Trivia Game is an effective tool for reviewing material related to neonatal emergency care decisions. Additional testing with a larger group would strengthen validity and reliability data.

Hand-held radiometry: A set of notes developed for use at the Workshop of Hand-held radiometry

NASA Technical Reports Server (NTRS)

Jackson, R. D.; Pinter, P. J., Jr.; Reginato, R. J.; Idso, S. B. (Principal Investigator)

1980-01-01

A set of notes was developed to aid the beginner in hand-held radiometry. The electromagnetic spectrum is reviewed, and pertinent terms are defined. View areas of multiband radiometers are developed to show the areas of coincidence of adjacent bands. The amounts of plant cover seen by radiometers having different fields of view are described. Vegetation indices are derived and discussed. Response functions of several radiometers are shown and applied to spectrometer data taken over 12 wheat plots, to provide a comparison of instruments and bands within and among instruments. The calculation of solar time is reviewed and applied to the calculation of the local time of LANDSAT satellite overpasses for any particular location in the Northern Hemisphere. The use and misuse of hand-held infrared thermometers are discussed, and a procedure for photographic determination of plant cover is described. Some suggestions are offered concerning procedures to be followed when collecting hand-held spectral and thermal data. A list of references pertinent to hand-held radiometry is included.

Ruminant Grazing of Cover Crops: Effects on Soil Properties and Agricultural Production

ERIC Educational Resources Information Center

Poffenbarger, Hanna

2010-01-01

Integrating livestock into a cropping system by allowing ruminant animals to graze cover crops may yield economic and environmental benefits. The effects of grazing on soil physical properties, soil organic matter, nitrogen cycling and agricultural production are presented in this literature review. The review found that grazing cover crops…

The Measurement of Protein in Powdered Milk Products and Infant Formulas: A Review and Recent Developments.

PubMed

Elgar, Dave; Evers, Jaap M; Holroyd, Stephen E; Johnson, Richard; Rowan, Angela

2016-01-01

Proteins are a key nutritional component of both powdered milk and infant formula types of product, and reliable methods for their determination are important for manufacturing and international trade. In this review, we distinguish between methods used for determining protein quality for nutrition purposes and those used for determining chemically defined protein. The former methods cover the ability of a dietary protein source to meet human nutritional requirements for the indispensable amino acids. The latter are chemical methods for the determination of total protein and can be divided into three broad types: total nitrogen determination, direct protein determination, and indirect protein determination. Current techniques and recent developments in each are reviewed.

Plant species potentially suitable for cover on low-level solid nuclear waste disposal sites: a literature review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brenkert, A.L.; Parr, P.D.; Taylor, F.G.

This report reviews available literature on soil conditions, hydrology, and climatological data and suggests plant species suitable for covering the low-level nuclear waste disposal areas in the White Oak Creek Watershed within the Oak Ridge Reservation. Literature on naturally invading species and secondary succession, on plant species used for reclamation of coal spoils and roadsides, and on horticultural species is reviewed. The potential of plant species to take up, or mine, the waste through deep rooting is assessed. The effects of vegetation cover on the water balance in a watershed are reviewed. Several conclusions are presented concerning the management ofmore » vegetation cover on low-level solid waste disposal areas. 163 references, 2 figures, 9 tables.« less

Personal factors in systemic sclerosis and their coverage by patient-reported outcome measures. A multicentre European qualitative study and literature review.

PubMed

Mattsson, M; Boström, C; Mihai, C; Stöcker, J; Geyh, S; Stummvoll, G; Gard, G; Möller, B; Hesselstrand, R; Sandqvist, G; Draghicescu, O; Gherghe, A M; Voicu, M; Distler, O; Smolen, J S; Stamm, T A

2015-08-01

Systemic sclerosis (SSc) is an autoimmune disease where thickening of the skin can lead to reduced body function and limitations in activities. Severe forms can also affect and seriously damage inner organs. Patient-centred rehabilitation emphasises considerations of patients' background, experience and behavior which highlights the need to know if patient-reported outcome measures (PROMs) include such personal factors. To identify and describe personal factors in the experiences of functioning and health of persons with SSc and to examine if and to what extent PROMs in SSc research cover these factors. Data from a qualitative study with focus group interviews were analysed. PROMs in SSc research were identified in a literature review between 2008-2013. Participants were recruited from outpatient clinics at rheumatology department. Sixty-three patients with SSc from four European countries participated. Data from interviews were analysed using a structure of personal factors developed by Geyh et al. Identified PROMs were analysed and linked to main concepts, related to the personal factors, found in the interview data. Nineteen main concepts were related to the area "patterns of experience and behaviour" in the personal factor structure, 16 to "thoughts and beliefs", nine to "feelings", one to "motives" and one to "personal history and biography", respectively. Among the 35 PROMs identified, 15 did not cover any of the identified concepts. Concepts within the area "feelings" were mostly covered by the PROMs. Five of the PROMs covered "patterns of experience and behaviour", while "motives" and "personal history and biography" were not covered at all. Four of the identified PROMs covered concepts within the areas "feelings", "thoughts and beliefs" and "patterns of experience and behaviour" in the same instrument. The Illness Cognition Questionnaire and Illness Behaviour Questionnaire were such PROMs. Patterns of experience and behaviour had the highest number of concepts related to personal factors, but few of the PROMs in SSc research covered these factors. Only a few PROMs covered several personal factors areas in the same instrument. The results would be of value when developing core sets for outcome measurements in SSc.

The history of antivenoms development: Beyond Calmette and Vital Brazil.

PubMed

Squaiella-Baptistão, Carla Cristina; Sant'Anna, Osvaldo Augusto; Marcelino, José Roberto; Tambourgi, Denise V

2018-05-17

This review presents the main contributions to our knowledge regarding the development of antivenoms for therapeutic use in victims of venomous animal bites. We cover the progress of serum therapy since tetanus and diphtheria antitoxins in Germany and France until the current scenario of antivenom production worldwide. During these more than 120 years of antivenom development, many researchers contributed to establish what are nowadays the antivenoms used for therapeutic purpose. The history of antivenoms development is fascinating! This review aims to recognize all those who contributed to the establishment of new sera, new methodologies and saving lives: much more than Calmette and Vital Brazil. Copyright © 2018 Elsevier Ltd. All rights reserved.

Engineering microbial hosts for production of bacterial natural products.

PubMed

Zhang, Mingzi M; Wang, Yajie; Ang, Ee Lui; Zhao, Huimin

2016-08-27

Covering up to end 2015Microbial fermentation provides an attractive alternative to chemical synthesis for the production of structurally complex natural products. In most cases, however, production titers are low and need to be improved for compound characterization and/or commercial production. Owing to advances in functional genomics and genetic engineering technologies, microbial hosts can be engineered to overproduce a desired natural product, greatly accelerating the traditionally time-consuming strain improvement process. This review covers recent developments and challenges in the engineering of native and heterologous microbial hosts for the production of bacterial natural products, focusing on the genetic tools and strategies for strain improvement. Special emphasis is placed on bioactive secondary metabolites from actinomycetes. The considerations for the choice of host systems will also be discussed in this review.

Antimalarial Activity of Plant Metabolites.

PubMed

Pan, Wen-Hui; Xu, Xin-Ya; Shi, Ni; Tsang, Siu Wai; Zhang, Hong-Jie

2018-05-06

Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum . As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled “Antimalarial activity of plant metabolites” by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

The Small Module Fixed Mirror Distributed Focus (FMDF) Photothermal Concentrator Study

NASA Technical Reports Server (NTRS)

Meinel, A. B.

1981-01-01

The development of a general ray trace evaluation program called ICARUS, the study of novel Fresnel concepts, and the review of a report draft on novel Fresnel concepts are covered. ICARUS is documented, reports on the novel Fresnel concepts were previously submitted.

34 CFR 668.145 - Test approval procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... appropriate advanced degrees and experience in test development or psychometric research, to determine whether... contain multiple sub-tests measuring content domains other than verbal and quantitative domains, the Secretary reviews only those sub-tests covering the verbal and quantitative domains. (b)(1) If the Secretary...

34 CFR 668.145 - Test approval procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... appropriate advanced degrees and experience in test development or psychometric research, to determine whether... contain multiple sub-tests measuring content domains other than verbal and quantitative domains, the Secretary reviews only those sub-tests covering the verbal and quantitative domains. (b)(1) If the Secretary...

34 CFR 668.145 - Test approval procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... appropriate advanced degrees and experience in test development or psychometric research, to determine whether... contain multiple sub-tests measuring content domains other than verbal and quantitative domains, the Secretary reviews only those sub-tests covering the verbal and quantitative domains. (b)(1) If the Secretary...

34 CFR 668.145 - Test approval procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... appropriate advanced degrees and experience in test development or psychometric research, to determine whether... contain multiple sub-tests measuring content domains other than verbal and quantitative domains, the Secretary reviews only those sub-tests covering the verbal and quantitative domains. (b)(1) If the Secretary...

THE BARKER HYPOTHESIS: IMPLICATIONS FOR FUTURE DIRECTIONS IN TOXICOLOGY RESEARCH

EPA Science Inventory

This review covers the past year’s papers germane to the Barker hypothesis. While much of the literature has centered on maternal and developmental nutrition, new findings have emerged on the ability of toxic exposures during development to impact fetal/developmental programming....

Isotopic Biogeochemistry

NASA Technical Reports Server (NTRS)

Hayes, J. M.

1985-01-01

An overview is provided of the biogeochemical research. The funding, productivity, personnel and facilities are reviewed. Some of the technical areas covered are: carbon isotopic records; isotopic studies of banded iron formations; isotope effects in microbial systems; studies of organic compounds in ancient sediments; and development in isotopic geochemistry and analysis.

Some Recent Developments in Turbulence Closure Modeling

NASA Astrophysics Data System (ADS)

Durbin, Paul A.

2018-01-01

Turbulence closure models are central to a good deal of applied computational fluid dynamical analysis. Closure modeling endures as a productive area of research. This review covers recent developments in elliptic relaxation and elliptic blending models, unified rotation and curvature corrections, transition prediction, hybrid simulation, and data-driven methods. The focus is on closure models in which transport equations are solved for scalar variables, such as the turbulent kinetic energy, a timescale, or a measure of anisotropy. Algebraic constitutive representations are reviewed for their role in relating scalar closures to the Reynolds stress tensor. Seamless and nonzonal methods, which invoke a single closure model, are reviewed, especially detached eddy simulation (DES) and adaptive DES. Other topics surveyed include data-driven modeling and intermittency and laminar fluctuation models for transition prediction. The review concludes with an outlook.

Space Acquisitions: Development and Oversight Challenges in Delivering Improved Space Situational Awareness Capabilities

DTIC Science & Technology

2011-05-01

information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and...OMB control number. 1 . REPORT DATE MAY 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Space...space operations depend. GAO was asked to ( 1 ) review key systems being planned and acquired to provide SSA, and their progress meeting cost

Air Mobility and the Development of Attack Aviation During the Vietnam War from 1965-1967

DTIC Science & Technology

2014-06-13

frame covered with thin sheet metal was vulnerable to small arms and heavy machine gun fire. The most vulnerable time was during the low-level...reviewing instructions, searching existing data sources , gathering and maintaining the data needed, and completing and reviewing this collection of...of on- call aircraft necessary for tactical support. The Air Force had additional missions that received higher apportionment based on strategic and

Treatment of Star Catalog Biases in Asteroid Astrometric Observations

DTIC Science & Technology

2010-01-01

90 to +40 (Zacharias et al., 2004). (Note: The recently introduced UCAC3 catalog (Zacharias et al., 2004) covers the entire sky, thus resolving ...the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the...Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 With the catalog biases resolved , a future paper will describe the subsequent development of a

Management systems research study

NASA Technical Reports Server (NTRS)

Bruno, A. V.

1975-01-01

The development of a Monte Carlo simulation of procurement activities at the NASA Ames Research Center is described. Data cover: simulation of the procurement cycle, construction of a performance evaluation model, examination of employee development, procedures and review of evaluation criteria for divisional and individual performance evaluation. Determination of the influences and apparent impact of contract type and structure and development of a management control system for planning and controlling manpower requirements.

Early Childhood Research & Practice: An Internet Journal on the Development, Care, and Education of Young Children, Spring 2001.

ERIC Educational Resources Information Center

Katz, Lilian G., Ed.; Rothenberg, Dianne, Ed.

2001-01-01

Early Childhood Research and Practice (ECRP), a peer-reviewed, Internet-only journal sponsored by the ERIC Clearinghouse on Elementary and Early Childhood Education (ERIC/EECE), covers topics related to the development, care, and education of children from birth to approximately age 8. The journal emphasizes articles reporting on practice-related…

Early Childhood Research & Practice: An Internet Journal on the Development, Care, and Education of Young Children, Spring 2003.

ERIC Educational Resources Information Center

Katz, Lilian G., Ed.; Rothenberg, Dianne, Ed.; Preece, Laurel

2003-01-01

Early Childhood Research and Practice (ECRP), a peer-reviewed Internet-only journal sponsored by the Early Childhood and Parenting (ECAP) Collaborative at the University of Illinois at Urbana-Champaign, covers topics related to the development, care, and education of children from birth to approximately age 8. The journal emphasizes articles…

Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations.

PubMed

Hofmann-Amtenbrink, Margarethe; Grainger, David W; Hofmann, Heinrich

2015-10-01

Although nanoparticles research is ongoing since more than 30years, the development of methods and standard protocols required for their safety and efficacy testing for human use is still in development. The review covers questions on toxicity, safety, risk and legal issues over the lifecycle of inorganic nanoparticles for medical applications. The following topics were covered: (i) In vitro tests may give only a very first indication of possible toxicity as in the actual methods interactions at systemic level are mainly neglected; (ii) the science-driven and the regulation-driven approaches do not really fit for decisive strategies whether or not a nanoparticle should be further developed and may receive a kind of "safety label". (iii) Cost and time of development are the limiting factors for the drug pipeline. Knowing which property of a nanoparticle makes it toxic it may be feasible to re-engineer the particle for higher safety (safety by design). Testing the safety and efficacy of nanoparticles for human use is still in need of standardization. In this concise review, the author described and discussed the current unresolved issues over the application of inorganic nanoparticles for medical applications. Copyright © 2015 Elsevier Inc. All rights reserved.

Masitinib in treatment of pancreatic cancer.

PubMed

Waheed, Anem; Purvey, Sneha; Saif, Muhammad Wasif

2018-05-01

Pancreatic cancer continues to have high mortality despite the development of many chemotherapeutic agents. The 5-year relative survival for stage IV patients is less than 3%. This urgent unmet need warrants the development of novel and active therapeutic agents, which focus both on targeting cancer cells and modifying the microenvironment of cancer cells. Areas covered: In this article, the authors review the development of masitinib, a novel tyrosine kinase inhibitor of numerous targets, including c-Kit, PDGFR and FGFR. This review covers its development from the bench to clinical trials assessing its potential in pancreatic cancer. Expert opinion: While masitinib has not shown an increase in overall survival (OS) or progression free survival (PFS) compared to the current standard of care in patients with pancreatic adenocarcinoma, masitinib may have a role in decreasing inflammation related to those patients with increased pain scores with pancreatic adenocarcinoma. If we have the tools to identify accurate subgroups of patients who may benefit from particular therapies, this agent may be of benefit to these patients. Indeed, if more sophisticated biomarkers and the identification of patient subgroups are better explained, the authors believe that masitinib will become part of the armamentarium against pancreatic adenocarcinoma.

Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).

PubMed

Kim, TaeHun; Pae, Ae Nim

2016-11-01

The translocator protein (TSPO) is an emerging target in diverse neurodegenerative diseases. Up-regulated TSPO in the central nervous system (CNS) appears to be involved in neuroinflammatory processes; therefore, the development of potent TSPO ligands is a promising method for alleviating or imaging patients with neurodegenerative diseases. Areas covered: This review will provide an overview of recently developed TSPO ligands patented from 2010 to 2015. Part 1 will present a summary focusing on TSPO ligands other than indole-based or cholesterol-like compounds, which will be discussed in part 2. Part 1 covers diverse benzodiazepine-derived analogues such as isoquinoline carboxamides and aryloxyanilides. Moreover, bicyclic ring structures such as imidazopyridine, pyrazolopyrimidine, and phenylpurine will be highlighted as promising scaffolds for TSPO ligands. A brief analysis of currently reported TSPO structures will also be covered in part 1. Expert opinion: Although the underlying pharmacological mechanism of TSPO remains to be elucidated, several TSPO ligands have shown therapeutic efficacy in experimental animal models of neurodegenerative diseases. In addition, radioactive TSPO ligands have been extensively studied for the diagnosis of neurodegenerative processes. Thus, further studies on both the basic and applied mechanisms of TSPO are warranted in the pursuit of successful pharmacological applications of TSPO ligands.

19 CFR 351.213 - Administrative review of orders and suspension agreements under section 751(a)(1) of the Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... concludes that, during the period covered by the review, there were no entries, exports, or sales of the... administrative review under this section will cover, as appropriate, entries, exports, or sales during the period... 19 Customs Duties 3 2010-04-01 2010-04-01 false Administrative review of orders and suspension...

Solid and Gaseous Fuels.

ERIC Educational Resources Information Center

Schultz, Hyman; And Others

1989-01-01

This review covers methods of sampling, analyzing, and testing coal, coke, and coal-derived solids and methods for the chemical, physical, and instrumental analyses of gaseous fuels. The review covers from October 1986, to September 1988. (MVL)

Textile Wastes.

ERIC Educational Resources Information Center

Talbot, R. S.

1978-01-01

Presents a literature review of wastes from textile industry, covering publications of 1977. This review covers studies such as removing heavy metals in textile wastes, and the biodegradability of six dyes. A list of references is also presented. (HM)

An overview of patent law as applied to the field of veterinary medicine.

PubMed

Gould, James M

2008-01-01

This article analyzes some of the challenges that can arise when patent law is applied to the field of veterinary medicine. Topics covered in this article include an overview of the different kinds of inventions that can be patented in the veterinary field; a review of recent legal developments that may affect the patenting of veterinary pharmaceuticals; a discussion of some potential issues related to patents covering assays; and an identification of some special situations where the law affecting veterinary pharmaceuticals is actually different from the law affecting human pharmaceuticals.

Copyright Law: A Guide for Public Schools.

ERIC Educational Resources Information Center

Steinhilber, August W.

As schools increasingly take advantage of sophisticated technologies to enhance education, their need to understand basic copyright law becomes more urgent. This reference guide reviews the historical development of copyright, examines basic components, and analyzes exceptions to copyright owners' rights. Also covered are key areas such as…

AIA SCHOOL PLANT STUDIES. A SELECTION 1952-1962.

ERIC Educational Resources Information Center

PAWLEY, ERIC

A COLLECTION OF 40 ARTICLES DISCUSSES VARIOUS ASPECTS OF SCHOOL PLANNING PROBLEMS. THOSE ON PRELIMINARY PHASES REVIEW--(1) ARCHITECT SELECTION, (2) DEVELOPMENT OF EDUCATIONAL PROGRAMS, AND (3) SCHOOL COSTS. ARCHITECTURALLY-)RIENTED ARTICLES COVER--(1) CONSTRUCTION AND STRUCTURAL TYPES, (2) STANDARD SCHOOL PLANS, (3) FLEXIBILITY, (4)…

NMR characterization of polymers: Review and update

USDA-ARS?s Scientific Manuscript database

NMR spectroscopy is a major technique for the characterization and analysis of polymers. A large number of methodologies have been developed in both the liquid and the solid state, and the literature has grown considerably (1-5). The field now covers a broad spectrum of activities, including polym...

A Look Inside Those Shiny Covers: Mass-Market Children's Books.

ERIC Educational Resources Information Center

Schulman, Janet

1982-01-01

Describes the intentions of mass-market children's book publishers, reviews the nature of mass-market children's books, discusses the interests of librarians in relation to recent developments in mass-market children's publishing, and considers the value of mass-market books to young readers. (JL)

2004 NASA Seal/Secondary Air System Workshop, Volume 1

NASA Technical Reports Server (NTRS)

2005-01-01

The 2004 NASA Seal/Secondary Air System workshop covered the following topics: (1) Overview of NASA s new Exploration Initiative program aimed at exploring the Moon, Mars, and beyond; (2) Overview of the NASA-sponsored Ultra-Efficient Engine Technology (UEET) program; (3) Overview of NASA Glenn s seal program aimed at developing advanced seals for NASA s turbomachinery, space, and reentry vehicle needs; (4) Reviews of NASA prime contractor and university advanced sealing concepts including tip clearance control, test results, experimental facilities, and numerical predictions; and (5) Reviews of material development programs relevant to advanced seals development. The NASA UEET overview illustrated for the reader the importance of advanced technologies, including seals, in meeting future turbine engine system efficiency and emission goals. For example, the NASA UEET program goals include an 8- to 15-percent reduction in fuel burn, a 15-percent reduction in CO2, a 70-percent reduction in NOx, CO, and unburned hydrocarbons, and a 30-dB noise reduction relative to program baselines. The workshop also covered several programs NASA is funding to develop technologies for the Exploration Initiative and advanced reusable space vehicle technologies. NASA plans on developing an advanced docking and berthing system that would permit any vehicle to dock to any on-orbit station or vehicle, as part of NASA s new Exploration Initiative. Plans to develop the necessary mechanism and androgynous seal technologies were reviewed. Seal challenges posed by reusable re-entry space vehicles include high-temperature operation, resiliency at temperature to accommodate gap changes during operation, and durability to meet mission requirements.

Clinical applications of PET in oncology.

PubMed

Rohren, Eric M; Turkington, Timothy G; Coleman, R Edward

2004-05-01

Positron emission tomography (PET) provides metabolic information that has been documented to be useful in patient care. The properties of positron decay permit accurate imaging of the distribution of positron-emitting radiopharmaceuticals. The wide array of positron-emitting radiopharmaceuticals has been used to characterize multiple physiologic and pathologic states. PET is used for characterizing brain disorders such as Alzheimer disease and epilepsy and cardiac disorders such as coronary artery disease and myocardial viability. The neurologic and cardiac applications of PET are not covered in this review. The major utilization of PET clinically is in oncology and consists of imaging the distribution of fluorine 18 fluorodeoxyglucose (FDG). FDG, an analogue of glucose, accumulates in most tumors in a greater amount than it does in normal tissue. FDG PET is being used in diagnosis and follow-up of several malignancies, and the list of articles supporting its use continues to grow. In this review, the physics and instrumentation aspects of PET are described. Many of the clinical applications in oncology are mature and readily covered by third-party payers. Other applications are being used clinically but have not been as carefully evaluated in the literature, and these applications may not be covered by third-party payers. The developing applications of PET are included in this review.

Microgravity Combustion Science: 1995 Program Update

NASA Technical Reports Server (NTRS)

Ross, Howard D. (Editor); Gokoglu, Suleyman A. (Editor); Friedman, Robert (Editor)

1995-01-01

Microgravity greatly benefits the study of fundamental combustion processes. In this environment, buoyancy-induced flow is nearly eliminated, weak or normally obscured forces and flows can be isolated, gravitational settling or sedimentation is nearly eliminated, and temporal and spatial scales can be expanded. This document reviews the state of knowledge in microgravity combustion science with the emphasis on NASA-sponsored developments in the current period of 1992 to early 1995. The subjects cover basic research in gaseous premixed and diffusion-flame systems, flame structure and sooting, liquid droplets and pools, and solid-surface ignition and flame spread. They also cover applied research in combustion synthesis of ceramic-metal composites, advanced diagnostic instrumentation, and on-orbit fire safety. The review promotes continuing research by describing the opportunities for Principal Investigator participation through the NASA Research Announcement program and the available NASA Lewis Research Center ground-based facilities and spaceflight accommodations. This review is compiled by the members and associates of the NASA Lewis Microgravity Combustion Branch, and it serves as an update of two previous overview reports.

Associations of Parental Influences with Physical Activity and Screen Time among Young Children: A Systematic Review

PubMed Central

2015-01-01

Parents play a critical role in developing and shaping their children's physical activity (PA) and sedentary behaviours, particularly in the early years of life. The aim of this systematic review is to identify current literature investigating associations of parental influences with both PA and screen time in young children. This systematic review was conducted in November 2013 using 6 electronic databases covering research literature from January 1998 to November 2013. Thirty articles that met inclusion criteria were identified. These studies covered five important aspects of parenting: (1) parenting practices; (2) parents' role modelling; (3) parental perceptions of children's PA and screen viewing behaviours; (4) parental self-efficacy; and (5) general parenting style. Findings suggest that parents' encouragement and support can increase children's PA, and reducing parents' own screen time can lead to decreased child screen time. Improving parenting practices, parental self-efficacy or changing parenting style may also be promising approaches to increasing PA time and decreasing screen time of young children. PMID:25874123

Associations of parental influences with physical activity and screen time among young children: a systematic review.

PubMed

Xu, Huilan; Wen, Li Ming; Rissel, Chris

2015-01-01

Parents play a critical role in developing and shaping their children's physical activity (PA) and sedentary behaviours, particularly in the early years of life. The aim of this systematic review is to identify current literature investigating associations of parental influences with both PA and screen time in young children. This systematic review was conducted in November 2013 using 6 electronic databases covering research literature from January 1998 to November 2013. Thirty articles that met inclusion criteria were identified. These studies covered five important aspects of parenting: (1) parenting practices; (2) parents' role modelling; (3) parental perceptions of children's PA and screen viewing behaviours; (4) parental self-efficacy; and (5) general parenting style. Findings suggest that parents' encouragement and support can increase children's PA, and reducing parents' own screen time can lead to decreased child screen time. Improving parenting practices, parental self-efficacy or changing parenting style may also be promising approaches to increasing PA time and decreasing screen time of young children.

Satellite Snow-Cover Mapping: A Brief Review

NASA Technical Reports Server (NTRS)

Hall, Dorothy K.

1995-01-01

Satellite snow mapping has been accomplished since 1966, initially using data from the reflective part of the electromagnetic spectrum, and now also employing data from the microwave part of the spectrum. Visible and near-infrared sensors can provide excellent spatial resolution from space enabling detailed snow mapping. When digital elevation models are also used, snow mapping can provide realistic measurements of snow extent even in mountainous areas. Passive-microwave satellite data permit global snow cover to be mapped on a near-daily basis and estimates of snow depth to be made, but with relatively poor spatial resolution (approximately 25 km). Dense forest cover limits both techniques and optical remote sensing is limited further by cloudcover conditions. Satellite remote sensing of snow cover with imaging radars is still in the early stages of research, but shows promise at least for mapping wet or melting snow using C-band (5.3 GHz) synthetic aperture radar (SAR) data. Observing System (EOS) Moderate Resolution Imaging Spectroradiometer (MODIS) data beginning with the launch of the first EOS platform in 1998. Digital maps will be produced that will provide daily, and maximum weekly global snow, sea ice and lake ice cover at 1-km spatial resolution. Statistics will be generated on the extent and persistence of snow or ice cover in each pixel for each weekly map, cloudcover permitting. It will also be possible to generate snow- and ice-cover maps using MODIS data at 250- and 500-m resolution, and to study and map snow and ice characteristics such as albedo. been under development. Passive-microwave data offer the potential for determining not only snow cover, but snow water equivalent, depth and wetness under all sky conditions. A number of algorithms have been developed to utilize passive-microwave brightness temperatures to provide information on snow cover and water equivalent. The variability of vegetative Algorithms are being developed to map global snow and ice cover using Earth Algorithms to map global snow cover using passive-microwave data have also cover and of snow grain size, globally, limits the utility of a single algorithm to map global snow cover.

Petroleum Processing Wastes.

ERIC Educational Resources Information Center

Baker, D. A.

1978-01-01

Presents a literature review of the petroleum processing wastes, covering publications of 1977. This review covers studies such as the use of activated carbon in petroleum and petrochemical waste treatment. A list of 15 references is also presented. (HM)

Accelerated aging: prediction of chemical stability of pharmaceuticals.

PubMed

Waterman, Kenneth C; Adami, Roger C

2005-04-11

Methods of rapidly and accurately assessing the chemical stability of pharmaceutical dosage forms are reviewed with respect to the major degradation mechanisms generally observed in pharmaceutical development. Methods are discussed, with the appropriate caveats, for accelerated aging of liquid and solid dosage forms, including small and large molecule active pharmaceutical ingredients. In particular, this review covers general thermal methods, as well as accelerated aging methods appropriate to oxidation, hydrolysis, reaction with reactive excipient impurities, photolysis and protein denaturation.

Improving the implementation of health workforce policies through governance: a review of case studies

PubMed Central

2011-01-01

Introduction Responsible governance is crucial to national development and a catalyst for achieving the Millennium Development Goals. To date, governance seems to have been a neglected issue in the field of human resources for health (HRH), which could be an important reason why HRH policy formulation and implementation is often poor. This article aims to describe how governance issues have influenced HRH policy development and to identify governance strategies that have been used, successfully or not, to improve HRH policy implementation in low- and middle-income countries (LMIC). Methods We performed a descriptive literature review of HRH case studies which describe or evaluate a governance-related intervention at country or district level in LMIC. In order to systematically address the term 'governance' a framework was developed and governance aspects were regrouped into four dimensions: 'performance', 'equity and equality', 'partnership and participation' and 'oversight'. Results and discussion In total 16 case studies were included in the review and most of the selected studies covered several governance dimensions. The dimension 'performance' covered several elements at the core of governance of HRH, decentralization being particularly prominent. Although improved equity and/or equality was, in a number of interventions, a goal, inclusiveness in policy development and fairness and transparency in policy implementation did often not seem adequate to guarantee the corresponding desirable health workforce scenario. Forms of partnership and participation described in the case studies are numerous and offer different lessons. Strikingly, in none of the articles was 'partnerships' a core focus. A common theme in the dimension of 'oversight' is local-level corruption, affecting, amongst other things, accountability and local-level trust in governance, and its cultural guises. Experiences with accountability mechanisms for HRH policy development and implementation were lacking. Conclusion This review shows that the term 'governance' is neither prominent nor frequent in recent HRH literature. It provides initial lessons regarding the influence of governance on HRH policy development and implementation. The review also shows that the evidence base needs to be improved in this field in order to better understand how governance influences HRH policy development and implementation. Tentative lessons are discussed, based on the case studies. PMID:21486438

Improving the implementation of health workforce policies through governance: a review of case studies.

PubMed

Dieleman, Marjolein; Shaw, Daniel Mp; Zwanikken, Prisca

2011-04-12

Responsible governance is crucial to national development and a catalyst for achieving the Millennium Development Goals. To date, governance seems to have been a neglected issue in the field of human resources for health (HRH), which could be an important reason why HRH policy formulation and implementation is often poor. This article aims to describe how governance issues have influenced HRH policy development and to identify governance strategies that have been used, successfully or not, to improve HRH policy implementation in low- and middle-income countries (LMIC). We performed a descriptive literature review of HRH case studies which describe or evaluate a governance-related intervention at country or district level in LMIC. In order to systematically address the term 'governance' a framework was developed and governance aspects were regrouped into four dimensions: 'performance', 'equity and equality', 'partnership and participation' and 'oversight'. In total 16 case studies were included in the review and most of the selected studies covered several governance dimensions. The dimension 'performance' covered several elements at the core of governance of HRH, decentralization being particularly prominent. Although improved equity and/or equality was, in a number of interventions, a goal, inclusiveness in policy development and fairness and transparency in policy implementation did often not seem adequate to guarantee the corresponding desirable health workforce scenario. Forms of partnership and participation described in the case studies are numerous and offer different lessons. Strikingly, in none of the articles was 'partnerships' a core focus. A common theme in the dimension of 'oversight' is local-level corruption, affecting, amongst other things, accountability and local-level trust in governance, and its cultural guises. Experiences with accountability mechanisms for HRH policy development and implementation were lacking. This review shows that the term 'governance' is neither prominent nor frequent in recent HRH literature. It provides initial lessons regarding the influence of governance on HRH policy development and implementation. The review also shows that the evidence base needs to be improved in this field in order to better understand how governance influences HRH policy development and implementation. Tentative lessons are discussed, based on the case studies.

You can't improve what you don't measure: Safety climate measures available in the German-speaking countries to support safety culture development in healthcare.

PubMed

Manser, Tanja; Brösterhaus, Mareen; Hammer, Antje

2016-01-01

Safety climate measurement is a key input into safety culture development. The aim of this review is to provide an overview of the safety climate measures that have been evaluated for their psychometric properties in a German-speaking country and to make recommendations on how to use them in quality and patient safety improvement. A systematic search strategy was implemented to obtain relevant articles. PubMed and Web of Science databases were searched, and 128 abstracts were identified. After application of limits, 33 full texts were retrieved for subsequent evaluation. Studies were included on the basis of predetermined inclusion criteria and independent assessment by two reviewers. Publications were reviewed concerning healthcare setting, target group, safety culture dimensions covered and results of their psychometric evaluation. This review identified 11 instruments for safety climate assessment in different healthcare settings (i. e. hospitals, nursing homes, primary care, dental care and community pharmacy) for which acceptable to good internal consistency was reported. We observed wide variability concerning the number of dimensions (1 to 14; in some cases including outcome dimensions) and items (9 to 128) that the instruments were comprised of. Nevertheless, consistency with regard to the thematic areas covered was rather high. While there is clear evidence that we can assess safety climate in healthcare, the application of safety climate measures by quality and patient safety practitioners has so far been rather limited. This review bridges this gap between research and improvement practice by highlighting the central role of safety climate assessment in a mixed methods approach to inform safety culture development. Copyright © 2016. Published by Elsevier GmbH.

Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies

PubMed Central

Jahangiri, Arman; Chin, Aaron T.; Flanigan, Patrick M.; Chen, Rebecca; Bankiewicz, Krystof; Aghi, Manish K.

2017-01-01

Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail. PMID:27035164

Assessment and control of spacecraft electromagnetic interference

NASA Technical Reports Server (NTRS)

1972-01-01

Design criteria are presented to provide guidance in assessing electromagnetic interference from onboard sources and establishing requisite control in spacecraft design, development, and testing. A comprehensive state-of-the-art review is given which covers flight experience, sources and transmission of electromagnetic interference, susceptible equipment, design procedure, control techniques, and test methods.

Catering Management in Higher Education. National Report.

ERIC Educational Resources Information Center

Higher Education Funding Council for England, Bristol.

This study identified the key management issues for senior managers and heads of catering services in higher education in developing and reviewing catering services. The study was conducted with the involvement of 76 universities and colleges with evidence drawn from questionnaires covering the Excellence Model's 9 criteria, an Expert Working…

Aeronautics. America in Space: The First Decade.

ERIC Educational Resources Information Center

Anderton, David A.

The major research and developments in aeronautics during the late 1950's and 1960's are reviewed descriptively with a minimum of technical content. Topics covered include aeronautical research, aeronautics in NASA, The National Advisory Committee for Aeronautics, the X-15 Research Airplane, variable-sweep wing design, the Supersonic Transport…

Smart Books: Thinking with a Purpose Across the Curriculum. Media Corner.

ERIC Educational Resources Information Center

Coleman, Rhoda, Ed.

1995-01-01

Presents reviews of four CD-ROM products developed by Scholastic Books, Inc. Maintains that each of the programs makes extensive use of primary sources and heighten student interest. Discusses products that cover Greek mythology, the sinking of the "Titanic," Malcolm X, and immigrants at Ellis Island. (CFR)

The Emerging Internet. Annual Review of the Institute for Information Studies.

ERIC Educational Resources Information Center

Institute for Information Studies, Falls Church, VA.

This document contains papers commissioned by the Institute for Information Studies to provide a variety of perspectives on a particular topic relating to the impact of communications and information technology. Among the subjects covered are the impact of the Internet on community, education, electronic commerce, international development, and…

Proceedings of the First Semiannual Distributed Receiver Program Review

NASA Technical Reports Server (NTRS)

1980-01-01

Point focus and line focus distributed receiver solar thermal technology for the production of electric power and of industrial process heat is addressed. Concentrator, receiver, and power conversion development are covered along with hardware tests and evaluation. Mass production costing, parabolic dish applications, and trough and bowl systems are included.

NASA SpaceWire Activities/Comments/Recommendations

NASA Technical Reports Server (NTRS)

Rakow, Glenn

2006-01-01

This viewgraph presentation reviews NASA's activities, and proposes recommendations for the further use of the SpaceWire (SpW). The areas covered in this presentation are: (1) Protocol ID assignment, (2) Protocol development, (3) Plug & Play (PnP), (4) Recommended additions t o SpW protocol and (5) SpaceFibre trade.

24 CFR 570.486 - Local government requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... such groups; (5) Provide for a minimum of two public hearings, each at a different stage of the program... review of program performance. The public hearings to cover community development and housing needs must... accommodations for the handicapped. Public hearings shall be conducted in a manner to meet the needs of non...

ADVANCED COMBUSTION SYSTEMS FOR STATIONARY GAS TURBINE ENGINES: VOLUME I. REVIEW AND PRELIMINARY EVALUATION

EPA Science Inventory

The reports describe an exploratory development program to identify, evaluate, and demonstrate dry techniques for significantly reducing NOx from thermal and fuel-bound sources in stationary gas turbine engines. Volume 1 covers Phase I of the four-phase effort. In Phase I, duty c...

Development and Validation of a Depression Scale for Asian Adolescents

ERIC Educational Resources Information Center

Woo, Bernardine S. C.; Chang, W. C.; Fung, Daniel S. S.; Koh, Jessie B. K.; Leong, Joyce S. F.; Kee, Carolyn H. Y.; Seah, Cheryl K. F.

2004-01-01

Items covering both core and culture-specific facets of depression were generated based on literature review and clinical experience. They were modified following focus group discussions with depressed adolescents and adolescents in the community. The newly constructed Asian Adolescent Depression Scale (AADS) was administered to a clinical and a…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalousek, D.K.; Fitch, N.; Paradice, B.

Topics covered in this book include a general review of normal embryonic and fetal development; abortion and the basic approach to the examination of aborted embryos and fetuses; and pathologic findings detected on examination of products of conception. The authors illustrate specific morphologic lesions and the variable expression of genetic syndromes in the embryonic and fetal periods.

78 FR 69104 - Second Allocation, Waivers, and Alternative Requirements for Grantees Receiving Community...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-18

... analyses of risks to infrastructure sectors from climate change and other hazards, such as the Northeast... interdependencies within and across communities and infrastructure sectors; changes to climate and development... biodiversity, and conserve natural resources in the face of a changing climate . . .'' h. HUD Review of Covered...

Electronic Document Management Systems: Where Are They Today?

ERIC Educational Resources Information Center

Koulopoulos, Thomas M.; Frappaolo, Carl

1993-01-01

Discusses developments in document management systems based on a survey of over 400 corporations and government agencies. Text retrieval and imaging markets, architecture and integration, purchasing plans, and vendor market leaders are covered. Five graphs present data on user preferences for improvements. A sidebar article reviews the development…

Researching Western History: Denver Public Library Is the Place to Go.

ERIC Educational Resources Information Center

Bond, Robert

1989-01-01

Reviews the development of the Western History Department of the Denver Public Library and describes the current collection, which includes military records, manuscripts and personal papers, newspapers, photographs, and paintings. The discussion covers library policies that balance public access and preservation, financial support for the…

Communique: Resources for Practicing Counselors, Volume 2, Number 4.

ERIC Educational Resources Information Center

Walz, Garry; And Others, Eds.

In this issue of Communique a program to enhance communication skills in counseling is presented. The books reviewed are about transactional analysis and behavioral self-control. The vibrations column covers new developments in various areas of counseling as well as recent research and materials. Other research is reported on. (WS)

24 CFR 570.486 - Local government requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... such groups; (5) Provide for a minimum of two public hearings, each at a different stage of the program... review of program performance. The public hearings to cover community development and housing needs must... accommodations for the handicapped. Public hearings shall be conducted in a manner to meet the needs of non...

Remote sensing-a geophysical perspective.

USGS Publications Warehouse

Watson, K.

1985-01-01

In this review of developments in the field of remote sensing from a geophysical perspective, the subject is limited to the electromagnetic spectrum from 0.4 mu m to 25cm. Three broad energy categories are covered: solar reflected, thermal infrared, and microwave.-from Authorremote sensing electromagnetic spectrum solar reflected thermal infrared microwave geophysics

Steel Industry Wastes.

ERIC Educational Resources Information Center

Schmidtke, N. W.; Averill, D. W.

1978-01-01

Presents a literature review of wastes from steel industry, covering publications of 1976-77. This review covers: (1) coke production; (2) iron and steel production; (3) rolling operations; and (4) surface treatment. A list of 133 references is also presented. (NM)

Acidic Ionic Liquids.

PubMed

Amarasekara, Ananda S

2016-05-25

Ionic liquid with acidic properties is an important branch in the wide ionic liquid field and the aim of this article is to cover all aspects of these acidic ionic liquids, especially focusing on the developments in the last four years. The structural diversity and synthesis of acidic ionic liquids are discussed in the introduction sections of this review. In addition, an unambiguous classification system for various types of acidic ionic liquids is presented in the introduction. The physical properties including acidity, thermo-physical properties, ionic conductivity, spectroscopy, and computational studies on acidic ionic liquids are covered in the next sections. The final section provides a comprehensive review on applications of acidic ionic liquids in a wide array of fields including catalysis, CO2 fixation, ionogel, electrolyte, fuel-cell, membrane, biomass processing, biodiesel synthesis, desulfurization of gasoline/diesel, metal processing, and metal electrodeposition.

Chemical Modification of Polysaccharides

PubMed Central

Cumpstey, Ian

2013-01-01

This review covers methods for modifying the structures of polysaccharides. The introduction of hydrophobic, acidic, basic, or other functionality into polysaccharide structures can alter the properties of materials based on these substances. The development of chemical methods to achieve this aim is an ongoing area of research that is expected to become more important as the emphasis on using renewable starting materials and sustainable processes increases in the future. The methods covered in this review include ester and ether formation using saccharide oxygen nucleophiles, including enzymatic reactions and aspects of regioselectivity; the introduction of heteroatomic nucleophiles into polysaccharide chains; the oxidation of polysaccharides, including oxidative glycol cleavage, chemical oxidation of primary alcohols to carboxylic acids, and enzymatic oxidation of primary alcohols to aldehydes; reactions of uronic-acid-based polysaccharides; nucleophilic reactions of the amines of chitosan; and the formation of unsaturated polysaccharide derivatives. PMID:24151557

Wastewater GHG Accounting Protocols as Compared to the State of GHG Science.

PubMed

Willis, John L; Yuan, Zhiguo; Murthy, Sudhir

2016-08-01

Greenhouse gas (GHG) accounting protocols have addressed emissions from wastewater conveyance and treatment using a variety of simplifying methodologies. While these methodologies vary to some degree by protocol, within each protocol they provide consistent tools for organizational entities of varying size and scope to report and verify GHG emissions. Much of the science supporting these methodologies is either limited or the protocols have failed to keep abreast of developing GHG research. This state-of-the-art review summarizes the sources of direct GHG emissions (both those covered and not covered in current protocols) from wastewater handling; provides a review of the wastewater-related methodologies in a select group of popular protocols; and discusses where research has out-paced protocol methodologies and other areas where the supporting science is relatively weak and warrants further exploration.

Cellular nanotechnology: making biological interfaces smarter.

PubMed

Mendes, Paula M

2013-12-21

Recently, there has been an outburst of research on engineered cell-material interfaces driven by nanotechnology and its tools and techniques. This tutorial review begins by providing a brief introduction to nanostructured materials, followed by an overview of the wealth of nanoscale fabrication and analysis tools available for their development. This background serves as the basis for a discussion of early breakthroughs and recent key developments in the endeavour to develop nanostructured materials as smart interfaces for fundamental cellular studies, tissue engineering and regenerative medicine. The review covers three major aspects of nanostructured interfaces - nanotopographical control, dynamic behaviour and intracellular manipulation and sensing - where efforts are continuously being made to further understand cell function and provide new ways to control cell behaviour. A critical reflection of the current status and future challenges are discussed as a conclusion to the review.

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

PubMed Central

Autry, Anita E.

2012-01-01

Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases. In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics. The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development. PMID:22407616

76 FR 26241 - Certain Frozen Warmwater Shrimp From Thailand: Notice of Court Decision Not in Harmony With Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-06

... Shrimp From Thailand: Notice of Court Decision Not in Harmony With Final Results of Administrative Review... Thailand covering the period of review (POR) of February 1, 2006, through January 31, 2007. DATES... administrative review of certain frozen warmwater shrimp from Thailand covering the POR of February 1, 2006...

Enhanced Evaporation and Condensation in Tubes

NASA Astrophysics Data System (ADS)

Honda, Hiroshi

A state-of-the-art review of enhanced evaporation and condensation in horizontal microfin tubes and micro-channels that are used for air-conditioning and refrigeration applications is presented. The review covers the effects of flow pattern and geometrical parameters of the tubes on the heat transfer performance. Attention is paid to the effect of surface tension which leads to enhanced evaporation and condensation in the microfin tubes and micro-channels. A review of prior efforts to develop empirical correlations of the heat transfer coefficient and theoretical models for evaporation and condensation in the horizontal microfin tubes and micro-channels is also presented.

[Quantitative estimation of vegetation cover and management factor in USLE and RUSLE models by using remote sensing data: a review].

PubMed

Wu, Chang-Guang; Li, Sheng; Ren, Hua-Dong; Yao, Xiao-Hua; Huang, Zi-Jie

2012-06-01

Soil loss prediction models such as universal soil loss equation (USLE) and its revised universal soil loss equation (RUSLE) are the useful tools for risk assessment of soil erosion and planning of soil conservation at regional scale. To make a rational estimation of vegetation cover and management factor, the most important parameters in USLE or RUSLE, is particularly important for the accurate prediction of soil erosion. The traditional estimation based on field survey and measurement is time-consuming, laborious, and costly, and cannot rapidly extract the vegetation cover and management factor at macro-scale. In recent years, the development of remote sensing technology has provided both data and methods for the estimation of vegetation cover and management factor over broad geographic areas. This paper summarized the research findings on the quantitative estimation of vegetation cover and management factor by using remote sensing data, and analyzed the advantages and the disadvantages of various methods, aimed to provide reference for the further research and quantitative estimation of vegetation cover and management factor at large scale.

Determinants of women's satisfaction with maternal health care: a review of literature from developing countries.

PubMed

Srivastava, Aradhana; Avan, Bilal I; Rajbangshi, Preety; Bhattacharyya, Sanghita

2015-04-18

Developing countries account for 99 percent of maternal deaths annually. While increasing service availability and maintaining acceptable quality standards, it is important to assess maternal satisfaction with care in order to make it more responsive and culturally acceptable, ultimately leading to enhanced utilization and improved outcomes. At a time when global efforts to reduce maternal mortality have been stepped up, maternal satisfaction and its determinants also need to be addressed by developing country governments. This review seeks to identify determinants of women's satisfaction with maternity care in developing countries. The review followed the methodology of systematic reviews. Public health and social science databases were searched. English articles covering antenatal, intrapartum or postpartum care, for either home or institutional deliveries, reporting maternal satisfaction from developing countries (World Bank list) were included, with no year limit. Out of 154 shortlisted abstracts, 54 were included and 100 excluded. Studies were extracted onto structured formats and analyzed using the narrative synthesis approach. Determinants of maternal satisfaction covered all dimensions of care across structure, process and outcome. Structural elements included good physical environment, cleanliness, and availability of adequate human resources, medicines and supplies. Process determinants included interpersonal behavior, privacy, promptness, cognitive care, perceived provider competency and emotional support. Outcome related determinants were health status of the mother and newborn. Access, cost, socio-economic status and reproductive history also influenced perceived maternal satisfaction. Process of care dominated the determinants of maternal satisfaction in developing countries. Interpersonal behavior was the most widely reported determinant, with the largest body of evidence generated around provider behavior in terms of courtesy and non-abuse. Other aspects of interpersonal behavior included therapeutic communication, staff confidence and competence and encouragement to laboring women. Quality improvement efforts in developing countries could focus on strengthening the process of care. Special attention is needed to improve interpersonal behavior, as evidence from the review points to the importance women attach to being treated respectfully, irrespective of socio-cultural or economic context. Further research on maternal satisfaction is required on home deliveries and relative strength of various determinants in influencing maternal satisfaction.

U.S. commercial space activities - Returning the U.S. to preeminence in space

NASA Technical Reports Server (NTRS)

Stone, Barbara A.

1987-01-01

The current status of NASA's activities related to the commercial development of space is reviewed with particular reference to the emerging new commercial space activities and the post-Challenger policy developments affecting space commerce. The discussion covers the development of U.S. private sector launching capabilities, cooperative agreements with the private sector, the NASA technology utilization program, the technology applications activities of the Office of Commercial Programs, and the activities of the Centers for the Commercial Development of Space program.

Text mining for search term development in systematic reviewing: A discussion of some methods and challenges.

PubMed

Stansfield, Claire; O'Mara-Eves, Alison; Thomas, James

2017-09-01

Using text mining to aid the development of database search strings for topics described by diverse terminology has potential benefits for systematic reviews; however, methods and tools for accomplishing this are poorly covered in the research methods literature. We briefly review the literature on applications of text mining for search term development for systematic reviewing. We found that the tools can be used in 5 overarching ways: improving the precision of searches; identifying search terms to improve search sensitivity; aiding the translation of search strategies across databases; searching and screening within an integrated system; and developing objectively derived search strategies. Using a case study and selected examples, we then reflect on the utility of certain technologies (term frequency-inverse document frequency and Termine, term frequency, and clustering) in improving the precision and sensitivity of searches. Challenges in using these tools are discussed. The utility of these tools is influenced by the different capabilities of the tools, the way the tools are used, and the text that is analysed. Increased awareness of how the tools perform facilitates the further development of methods for their use in systematic reviews. Copyright © 2017 John Wiley & Sons, Ltd.

Measuring team factors thought to influence the success of quality improvement in primary care: a systematic review of instruments

PubMed Central

2013-01-01

Background Measuring team factors in evaluations of Continuous Quality Improvement (CQI) may provide important information for enhancing CQI processes and outcomes; however, the large number of potentially relevant factors and associated measurement instruments makes inclusion of such measures challenging. This review aims to provide guidance on the selection of instruments for measuring team-level factors by systematically collating, categorizing, and reviewing quantitative self-report instruments. Methods Data sources: We searched MEDLINE, PsycINFO, and Health and Psychosocial Instruments; reference lists of systematic reviews; and citations and references of the main report of instruments. Study selection: To determine the scope of the review, we developed and used a conceptual framework designed to capture factors relevant to evaluating CQI in primary care (the InQuIRe framework). We included papers reporting development or use of an instrument measuring factors relevant to teamwork. Data extracted included instrument purpose; theoretical basis, constructs measured and definitions; development methods and assessment of measurement properties. Analysis and synthesis: We used qualitative analysis of instrument content and our initial framework to develop a taxonomy for summarizing and comparing instruments. Instrument content was categorized using the taxonomy, illustrating coverage of the InQuIRe framework. Methods of development and evidence of measurement properties were reviewed for instruments with potential for use in primary care. Results We identified 192 potentially relevant instruments, 170 of which were analyzed to develop the taxonomy. Eighty-one instruments measured constructs relevant to CQI teams in primary care, with content covering teamwork context (45 instruments measured enabling conditions or attitudes to teamwork), team process (57 instruments measured teamwork behaviors), and team outcomes (59 instruments measured perceptions of the team or its effectiveness). Forty instruments were included for full review, many with a strong theoretical basis. Evidence supporting measurement properties was limited. Conclusions Existing instruments cover many of the factors hypothesized to contribute to QI success. With further testing, use of these instruments measuring team factors in evaluations could aid our understanding of the influence of teamwork on CQI outcomes. Greater consistency in the factors measured and choice of measurement instruments is required to enable synthesis of findings for informing policy and practice. PMID:23410500

Taxane anticancer agents: a patent perspective

PubMed Central

Ojima, Iwao; Lichtenthal, Brendan; Lee, Siyeon; Wang, Changwei; Wang, Xin

2016-01-01

Introduction Paclitaxel and docetaxel were two epoch-making anticancer drugs and have been successfully used in chemotherapy for a variety of cancer types. In 2010, a new taxane, cabazitaxel, was approved by FDA for use in combination with prednisone for the treatment of metastatic hormone-refractory prostate cancer. Albumin-bound paclitaxel (nab™-paclitaxel; abraxane) nanodroplet formulation was another notable invention (FDA approval 2005 for refractory, metastatic, or relapsed breast cancer). Abraxane in combination with gemcitabine for the treatment of pancreatic cancer was approved by FDA in 2013. Accordingly, there have been a huge number of patent applications dealing with taxane anticancer agents in the last five years. Thus, it is a good time to review the progress in this area and find the next wave for new developments. Area covered This review article covers the patent literature from 2010 to early 2015 on various aspects of taxane-based chemotherapies and drug developments. Expert opinion Three FDA-approved taxane anticancer drugs will continue to expand their therapeutic applications, especially through drug combinations and new formulations. Inspired by the success of abraxane, new nano-formulations are emerging. Highly potent new-generation taxanes will play a key role in the development of efficacious tumor-targeted drug delivery systems. PMID:26651178

State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.

PubMed

Asan, Esther; Drenckhahn, Detlev

2008-12-01

Investigations of cell and tissue structure and function using innovative methods and approaches have again yielded numerous exciting findings in recent months and have added important data to current knowledge, inspiring new ideas and hypotheses in various fields of modern life sciences. Topics and contents of comprehensive expert reviews covering different aspects in methodological advances, cell biology, tissue function and morphology, and novel findings reported in original papers are summarized in the present review.

ROBIS: A new tool to assess risk of bias in systematic reviews was developed.

PubMed

Whiting, Penny; Savović, Jelena; Higgins, Julian P T; Caldwell, Deborah M; Reeves, Barnaby C; Shea, Beverley; Davies, Philippa; Kleijnen, Jos; Churchill, Rachel

2016-01-01

To develop ROBIS, a new tool for assessing the risk of bias in systematic reviews (rather than in primary studies). We used four-stage approach to develop ROBIS: define the scope, review the evidence base, hold a face-to-face meeting, and refine the tool through piloting. ROBIS is currently aimed at four broad categories of reviews mainly within health care settings: interventions, diagnosis, prognosis, and etiology. The target audience of ROBIS is primarily guideline developers, authors of overviews of systematic reviews ("reviews of reviews"), and review authors who might want to assess or avoid risk of bias in their reviews. The tool is completed in three phases: (1) assess relevance (optional), (2) identify concerns with the review process, and (3) judge risk of bias. Phase 2 covers four domains through which bias may be introduced into a systematic review: study eligibility criteria; identification and selection of studies; data collection and study appraisal; and synthesis and findings. Phase 3 assesses the overall risk of bias in the interpretation of review findings and whether this considered limitations identified in any of the phase 2 domains. Signaling questions are included to help judge concerns with the review process (phase 2) and the overall risk of bias in the review (phase 3); these questions flag aspects of review design related to the potential for bias and aim to help assessors judge risk of bias in the review process, results, and conclusions. ROBIS is the first rigorously developed tool designed specifically to assess the risk of bias in systematic reviews. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

10 CFR 950.22 - Covered event determination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Covered event determination. 950.22 Section 950.22 Energy... Covered event determination. (a) Completeness review. Upon notification of a covered event from the... with paragraph (c) of this section. (b) Covered Event Determination. The Claims Administrator shall...

10 CFR 950.22 - Covered event determination.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Covered event determination. 950.22 Section 950.22 Energy... Covered event determination. (a) Completeness review. Upon notification of a covered event from the... with paragraph (c) of this section. (b) Covered Event Determination. The Claims Administrator shall...

10 CFR 950.22 - Covered event determination.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Covered event determination. 950.22 Section 950.22 Energy... Covered event determination. (a) Completeness review. Upon notification of a covered event from the... with paragraph (c) of this section. (b) Covered Event Determination. The Claims Administrator shall...

10 CFR 950.22 - Covered event determination.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Covered event determination. 950.22 Section 950.22 Energy... Covered event determination. (a) Completeness review. Upon notification of a covered event from the... with paragraph (c) of this section. (b) Covered Event Determination. The Claims Administrator shall...

10 CFR 950.22 - Covered event determination.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Covered event determination. 950.22 Section 950.22 Energy... Covered event determination. (a) Completeness review. Upon notification of a covered event from the... with paragraph (c) of this section. (b) Covered Event Determination. The Claims Administrator shall...

Nuclear Propulsion Technical Interchange Meeting, volume 2

NASA Technical Reports Server (NTRS)

1993-01-01

The purpose of the meeting was to review the work performed in fiscal year 1992 in the areas of nuclear thermal and nuclear electric propulsion technology development. These proceedings are an accumulation of the presentations provided at the meeting along with annotations provided by authors. The proceedings cover system concepts, technology development, and system modeling for nuclear thermal propulsion (NTP) and nuclear electric propulsion (NEP). The test facilities required for the development of the nuclear propulsion systems are also discussed.

Fish and Shellfish Associated Disease Outbreaks.

ERIC Educational Resources Information Center

Levin, M.

1978-01-01

Presents a literature review of disease outbreaks related to fish and shellfish, covering publications of 1976-77. This review covers the chemical, bacterial, and viral diseases that are transmitted by fish and shellfish. A list of 50 references is also presented. (HM)

Electroplating and Cyanide Waste.

ERIC Educational Resources Information Center

Torpy, Michael F.; Runke, Henry M.

1978-01-01

Presents a literature review of wastes from electroplating industry, covering publications of 1977. This review covers studies such as: (1) ion exchange treatment process; (2) use of reverse osmosis; and (3) cyanide removal and detection. A list of 75 references is also presented. (HM)

A Meta-Analytic Review of the Cover-Copy-Compare and Variations of This Self-Management Procedure

ERIC Educational Resources Information Center

Joseph, Laurice M.; Konrad, Moira; Cates, Gary; Vajcner, Terra; Eveleigh, Elisha; Fishley, Katelyn M.

2012-01-01

Studies that examined copy-cover-compare (CCC) and variations of this procedure were reviewed and analyzed. This review revealed a substantial number of studies that validated the use of CCC across spelling and math skills and across students with and without disabilities. A meta-analysis of findings indicated that CCC and variations of this…

ROBIS: A new tool to assess risk of bias in systematic reviews was developed

PubMed Central

Whiting, Penny; Savović, Jelena; Higgins, Julian P.T.; Caldwell, Deborah M.; Reeves, Barnaby C.; Shea, Beverley; Davies, Philippa; Kleijnen, Jos; Churchill, Rachel

2016-01-01

Objective To develop ROBIS, a new tool for assessing the risk of bias in systematic reviews (rather than in primary studies). Study Design and Setting We used four-stage approach to develop ROBIS: define the scope, review the evidence base, hold a face-to-face meeting, and refine the tool through piloting. Results ROBIS is currently aimed at four broad categories of reviews mainly within health care settings: interventions, diagnosis, prognosis, and etiology. The target audience of ROBIS is primarily guideline developers, authors of overviews of systematic reviews (“reviews of reviews”), and review authors who might want to assess or avoid risk of bias in their reviews. The tool is completed in three phases: (1) assess relevance (optional), (2) identify concerns with the review process, and (3) judge risk of bias. Phase 2 covers four domains through which bias may be introduced into a systematic review: study eligibility criteria; identification and selection of studies; data collection and study appraisal; and synthesis and findings. Phase 3 assesses the overall risk of bias in the interpretation of review findings and whether this considered limitations identified in any of the phase 2 domains. Signaling questions are included to help judge concerns with the review process (phase 2) and the overall risk of bias in the review (phase 3); these questions flag aspects of review design related to the potential for bias and aim to help assessors judge risk of bias in the review process, results, and conclusions. Conclusions ROBIS is the first rigorously developed tool designed specifically to assess the risk of bias in systematic reviews. PMID:26092286

Recent developments in seismic seabed oil reservoir monitoring applications using fibre-optic sensing networks

NASA Astrophysics Data System (ADS)

De Freitas, J. M.

2011-05-01

This review looks at recent developments in seismic seabed oil reservoir monitoring techniques using fibre-optic sensing networks. After a brief introduction covering the background and scope of the review, the following section focuses on state-of-the-art fibre-optic hydrophones and accelerometers used for seismic applications. Related metrology aspects of the sensor such as measurement of sensitivity, noise and cross-axis performance are addressed. The third section focuses on interrogation systems. Two main phase-based competing systems have emerged over the past two decades for seismic applications, with a third technique showing much promise; these have been compared in terms of general performance.

Interactive boundary delineation of agricultural lands using graphics workstations

NASA Technical Reports Server (NTRS)

Cheng, Thomas D.; Angelici, Gary L.; Slye, Robert E.; Ma, Matt

1992-01-01

A review is presented of the computer-assisted stratification and sampling (CASS) system developed to delineate the boundaries of sample units for survey procedures. CASS stratifies the sampling units by land-cover and land-use type, employing image-processing software and hardware. This procedure generates coverage areas and the boundaries of stratified sampling units that are utilized for subsequent sampling procedures from which agricultural statistics are developed.

Satellite services system analysis study. Volume 5: Programmatics

NASA Technical Reports Server (NTRS)

1981-01-01

The overall program and resources needed for development and operation of a Satellite Services System is reviewed. Program requirements covered system operations through 1993 and were completed in preliminary form. Program requirements were refined based on equipment preliminary design and analysis. Schedules, costs, equipment utilization, and facility/advanced technology requirements were included in the update. Equipment user charges were developed for each piece of equipment and for representative satellite servicing missions.

Pathological diagnostic criterion of blood and lymphatic vessel invasion in colorectal cancer: a framework for developing an objective pathological diagnostic system using the Delphi method, from the Pathology Working Group of the Japanese Society for Cancer of the Colon and Rectum.

PubMed

Kojima, Motohiro; Shimazaki, Hideyuki; Iwaya, Keiichi; Kage, Masayoshi; Akiba, Jun; Ohkura, Yasuo; Horiguchi, Shinichiro; Shomori, Kohei; Kushima, Ryoji; Ajioka, Yoichi; Nomura, Shogo; Ochiai, Atsushi

2013-07-01

The goal of this study is to create an objective pathological diagnostic system for blood and lymphatic vessel invasion (BLI). 1450 surgically resected colorectal cancer specimens from eight hospitals were reviewed. Our first step was to compare the current practice of pathology assessment among eight hospitals. Then, H&E stained slides with or without histochemical/immunohistochemical staining were assessed by eight pathologists and concordance of BLI diagnosis was checked. In addition, histological findings associated with BLI having good concordance were reviewed. Based on these results, framework for developing diagnostic criterion was developed, using the Delphi method. The new criterion was evaluated using 40 colorectal cancer specimens. Frequency of BLI diagnoses, number of blocks obtained and stained for assessment of BLI varied among eight hospitals. Concordance was low for BLI diagnosis and was not any better when histochemical/immunohistochemical staining was provided. All histological findings associated with BLI from H&E staining were poor in agreement. However, observation of elastica-stained internal elastic membrane covering more than half of the circumference surrounding the tumour cluster as well as the presence of D2-40-stained endothelial cells covering more than half of the circumference surrounding the tumour cluster showed high concordance. Based on this observation, we developed a framework for pathological diagnostic criterion, using the Delphi method. This criterion was found to be useful in improving concordance of BLI diagnosis. A framework for pathological diagnostic criterion was developed by reviewing concordance and using the Delphi method. The criterion developed may serve as the basis for creating a standardised procedure for pathological diagnosis.

Pathological diagnostic criterion of blood and lymphatic vessel invasion in colorectal cancer: a framework for developing an objective pathological diagnostic system using the Delphi method, from the Pathology Working Group of the Japanese Society for Cancer of the Colon and Rectum

PubMed Central

Kojima, Motohiro; Shimazaki, Hideyuki; Iwaya, Keiichi; Kage, Masayoshi; Akiba, Jun; Ohkura, Yasuo; Horiguchi, Shinichiro; Shomori, Kohei; Kushima, Ryoji; Ajioka, Yoichi; Nomura, Shogo; Ochiai, Atsushi

2013-01-01

Aims The goal of this study is to create an objective pathological diagnostic system for blood and lymphatic vessel invasion (BLI). Methods 1450 surgically resected colorectal cancer specimens from eight hospitals were reviewed. Our first step was to compare the current practice of pathology assessment among eight hospitals. Then, H&E stained slides with or without histochemical/immunohistochemical staining were assessed by eight pathologists and concordance of BLI diagnosis was checked. In addition, histological findings associated with BLI having good concordance were reviewed. Based on these results, framework for developing diagnostic criterion was developed, using the Delphi method. The new criterion was evaluated using 40 colorectal cancer specimens. Results Frequency of BLI diagnoses, number of blocks obtained and stained for assessment of BLI varied among eight hospitals. Concordance was low for BLI diagnosis and was not any better when histochemical/immunohistochemical staining was provided. All histological findings associated with BLI from H&E staining were poor in agreement. However, observation of elastica-stained internal elastic membrane covering more than half of the circumference surrounding the tumour cluster as well as the presence of D2-40-stained endothelial cells covering more than half of the circumference surrounding the tumour cluster showed high concordance. Based on this observation, we developed a framework for pathological diagnostic criterion, using the Delphi method. This criterion was found to be useful in improving concordance of BLI diagnosis. Conclusions A framework for pathological diagnostic criterion was developed by reviewing concordance and using the Delphi method. The criterion developed may serve as the basis for creating a standardised procedure for pathological diagnosis. PMID:23592799

Saxon Math. What Works Clearinghouse Intervention Report

ERIC Educational Resources Information Center

What Works Clearinghouse, 2010

2010-01-01

"Saxon Math" is a textbook series covering grades K-12 based on incremental development and continual review of mathematical concepts to give students time to learn and practice concepts throughout the year. The series is aligned with standards of the National Council of Teachers of Mathematics (NCTM) and various states, and can be…

Modelling of auroral electrodynamical processes: Magnetosphere to mesosphere

NASA Technical Reports Server (NTRS)

Chiu, Y. T.; Gorney, D. J.; Kishi, A. M.; Newman, A. L.; Schulz, M.; Walterscheid, R. L.; CORNWALL; Prasad, S. S.

1982-01-01

Research conducted on auroral electrodynamic coupling between the magnetosphere and ionosphere-atmosphere in support of the development of a global scale kinetic plasma theory is reviewed. Topics covered include electric potential structure in the evening sector; morning and dayside auroras; auroral plasma formation; electrodynamic coupling with the thermosphere; and auroral electron interaction with the atmosphere.

Spoken English. "Educational Review" Occasional Publications Number Two.

ERIC Educational Resources Information Center

Wilkinson, Andrew; And Others

Modifications of current assumptions both about the nature of the spoken language and about its functions in relation to personality development are suggested in this book. The discussion covers an explanation of "oracy" (the oral skills of speaking and listening); the contributions of linguistics to the teaching of English in Britain; the…

Recent Developments in VSD Imaging of Small Neuronal Networks

ERIC Educational Resources Information Center

Hill, Evan S.; Bruno, Angela M.; Frost, William N.

2014-01-01

Voltage-sensitive dye (VSD) imaging is a powerful technique that can provide, in single experiments, a large-scale view of network activity unobtainable with traditional sharp electrode recording methods. Here we review recent work using VSDs to study small networks and highlight several results from this approach. Topics covered include circuit…

Interface between Education and Technology: Australia. Education and Polity 1.

ERIC Educational Resources Information Center

Birch, Ian; And Others

The first of three main sections in this review of research covers current and recent developments in the interfacing of education and technology in Australia, with particular attention paid to policy initiatives adopted by governments, industry, academic institutions, and the community with respect to the interface. The second part reviews…

Exercises to Accompany Mathematics 301. Curriculum Support Series.

ERIC Educational Resources Information Center

Manitoba Dept. of Education, Winnipeg.

Because of the extensiveness of the course outline for Math 301 (Manitoba Department of Education), schools would have had to purchase several different textbooks to cover the material adequately. Therefore, a set of materials to supplement the guide was developed. The exercises, projects, and reviews contained in this package are keyed to the 301…

Education and Conservation Benefits of Marine Wildlife Tours: Developing Free-Choice Learning Experiences

ERIC Educational Resources Information Center

Zeppel, Heather

2008-01-01

Marine wildlife tours can provide a range of education and conservation benefits for visitors, including emotional (i.e., affective) responses and learning (i.e., cognition). Interpretive programs cover the biology, ecology, and behavior of marine species; best practice guidelines; and human threats to marine areas. The author reviews the…

Forestation of surface mines for wildlife

Treesearch

Thomas G. Zarger

1980-01-01

This report reviews TVA program efforts to promote the use of wildlife shrubs in mined-land reclamation including work on plant materials development, demonstrations to acquaint landowners with a variety of food and cover plants, and action programs to incorporate wildlife plants into postmining land use. It deals briefly with wildlife considerations under Public Law...

Making Room for Values and Fairness: Teaching Reliability and Validity in the Classroom Context.

ERIC Educational Resources Information Center

Whittington, Dale

1999-01-01

Explores how reliability and validity of assessment results should be conceived and covered in teacher education. Discusses each of the standards for teacher competence in assessment developed by the American Federation of Teachers in conjunction with other groups. Reviews coverage of these topics in frequently used textbooks. (SLD)

The NASA research program on propulsion for supersonic cruise aircraft

NASA Technical Reports Server (NTRS)

Weber, R. J.

1975-01-01

The objectives and status of the propulsion portion of a program aimed at advancing the technology and establishing a data base appropriate for the possible future development of supersonic cruise aircraft are reviewed. Research related to exhaust nozzles, combustors, and inlets that is covered by the noise, pollution, and dynamics programs is described.

Fundamentals of Digital Logic, 7-1. Military Curriculum Materials for Vocational and Technical Education.

ERIC Educational Resources Information Center

Marine Corps, Washington, DC.

Targeted for grades 10 through adult, these military-developed curriculum materials consist of a student lesson book with text readings and review exercises designed to prepare electronic personnel for further training in digital techniques. Covered in the five lessons are binary arithmetic (number systems, decimal systems, the mathematical form…

Civics Education for Adult English Language Learners. ERIC Q & A.

ERIC Educational Resources Information Center

Terrill, Lynda

This article provides a brief historical review of efforts to prepare immigrants to pass the U.S. citizenship test, defines key terms, discusses events that have shaped civics education, and offers suggestions, whatever the approach chosen, for integrating civics content with English-as-a-Second-Language (ESL) skills development. Covered topics…

Semiochemicals in pest management: development, regulation and applications. Subtitle: Delivering on the promise of pheromones

USDA-ARS?s Scientific Manuscript database

In this special issue, we present a total of 20 review articles and original research papers in semiochemical applications from not only insects, also in some vertebrates. We have covered many areas of using chemical ecology tools for practical applications from all four continents, which include ph...

A patient mobility framework that travels: European and United States-Mexican comparisons.

PubMed

Laugesen, Miriam J; Vargas-Bustamante, Arturo

2010-10-01

To develop a framework that parsimoniously explains divergent patient mobility in the United States and Europe. Review of studies of patient mobility; data from the 2007 Flash Eurobarometer and the 2001 California Health Interview Survey was analyzed; and we reviewed government policies and documents in the United States and Europe. Four types of patient mobility are defined: primary, complementary, duplicative, and institutionalized. Primary exit occurs when people without comprehensive insurance travel because they cannot afford to pay for health insurance or directly finance care, as in the United States and Mexico. Second, people will exit to buy complementary services not covered, or partially covered by domestic health insurance, in both the United States and Europe. Third, in Europe, patient mobility for duplicative services provides faster or better quality treatment. Finally, governments and insurers can encourage institutionalized exit through expanded delivery options and financing. Institutionalized exit is developing in Europe, but uncoordinated and geographically limited in the United States. This parsimonious framework explains patient mobility by considering domestic health system characteristics relating to cost and quality. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

2001 NASA Seal/secondary Air System Workshop, Volume 1. Volume 1

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M. (Editor); Hendricks, Robert C. (Editor)

2002-01-01

The 2001 NASA Seal/Secondary Air System Workshop covered the following topics: (i) overview of NASA's Vision for 21st Century Aircraft; (ii) overview of NASA-sponsored Ultra-Efficient Engine Technology (UEET); (iii) reviews of sealing concepts, test results, experimental facilities, and numerical predictions; and (iv) reviews of material development programs relevant to advanced seals development. The NASA UEET overview illustrates for the reader the importance of advanced technologies, including seals, in meeting future turbine engine system efficiency and emission goals. The NASA UEET program goals include an 8-to 15-percent reduction in fuel burn, a 15-percent reduction in CO2, a 70-percent reduction in NOx, CO, and unburned hydrocarbons, and a 30-dB noise reduction relative to program baselines. The workshop also covered several programs NASA is funding to investigate advanced reusable space vehicle technologies (X-38) and advanced space ram/scramjet propulsion systems. Seal challenges posed by these advanced systems include high-temperature operation, resiliency at the operating temperature to accommodate sidewall flexing, and durability to last many missions.

Occupational and Environmental Contributions to Chronic Cough in Adults: Chest Expert Panel Report.

PubMed

Tarlo, Susan M; Altman, Kenneth W; Oppenheimer, John; Lim, Kaiser; Vertigan, Anne; Prezant, David; Irwin, Richard S

2016-10-01

In response to occupational and environmental exposures, cough can be an isolated symptom reflecting exposure to an irritant with little physiological consequence, or it can be a manifestation of more significant disease. This document reviews occupational and environmental contributions to chronic cough in adults, focusing on aspects not previously covered in the 2006 ACCP Cough Guideline or our more recent systematic review, and suggests an approach to investigation of these factors when suspected. MEDLINE and TOXLINE literature searches were supplemented by articles identified by the cough panel occupational and environmental subgroup members, to identify occupational and environmental aspects of chronic cough not previously covered in the 2006 ACCP Cough Guideline. Based on the literature reviews and the Delphi methodology, the cough panel occupational and environmental subgroup developed guideline suggestions that were approved after review and voting by the full cough panel. The literature review identified relevant articles regarding: mechanisms; allergic environmental causes; chronic cough and the recreational and involuntary inhalation of tobacco and marijuana smoke; nonallergic environmental triggers; laryngeal syndromes; and occupational diseases and exposures. Consensus-based statements were developed for the approach to diagnosis due to a lack of strong evidence from published literature. Despite increased understanding of cough related to occupational and environmental triggers, there remains a gap between the recommended assessment of occupational and environmental causes of cough and the reported systematic assessment of these factors. There is a need for further documentation of occupational and environmental causes of cough in the future. Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

Dairy Wastes.

ERIC Educational Resources Information Center

Pico, Richard F.

1978-01-01

Presents a literature review of wastes from the dairy industry covering publications of 1976-77. This review covers: (1) government regulations; (2) ion-plant control of dairy effluents; (3) dairy effluent treatment methods; and (4) research on dairy effluents. A list of 26 references is also presented. (HM)

Solid Wastes and Water Quality.

ERIC Educational Resources Information Center

DeWalle, F. B.; Chian, E. S. K.

1978-01-01

Presents a literature review of solid wastes and water quality, covering publications of 1976-77. This review covers areas such as: (1) environmental impacts and health aspects for waste disposal, and (2) processed and hazardous wastes. A list of 80 references is also presented. (HM)

Assessing the economic impact of Rx-to-OTC switches: systematic review and guidelines for future development.

PubMed

Cohen, J; Millier, A; Karray, S; Toumi, M

2013-01-01

Switching drugs from prescription to non-prescription status (Rx-to-OTC) presents a unique set of challenges and opportunities to policy-makers and the industry in terms of managing health outcomes, pharmaceutical spending, and steering of consumer choices of therapy. Decision-analytic models are used to address uncertainty and produce reasonable estimates of the economic impact of switches for payers. This article presents a critical literature review of existing models which assess the economic impact of Rx-to-OTC switches, and provides guidelines in which future economic evaluations of Rx-to-OTC switches could be improved. A comprehensive search strategy was implemented in Medline and Embase, to retrieve published economic evaluations on Rx-to-OTC switches from 1995-2010. The research digest of the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) was reviewed for potentially relevant abstracts for the past 3 years. Each model used was critically evaluated in terms of structure, relevance of inputs, methodology used, and robustness of results. Worldwide, the economic impact of Rx-to-OTC switches has only been evaluated in a total of 12 peer-reviewed publications. Ten out of 12 studies were US-based, and two European-based. The models covered various disease categories, including allergy, hypercholesterolemia, gastroenterology, contraception, pulmonology, and virology. Seventy-five per cent of the models predicted cost savings for payers and patients. Limitations of the models mainly included use of strong assumptions and non-inclusion of specific populations due to lack of data. Guidelines were developed to help future model development. They cover structural issues on decision context, health states, and clinical outcomes, and other considerations for model specifications. Although reviewed studies lacked quality, this review of economic evidence of Rx-to-OTC switches suggests that switches may produce cost savings to public and private payers. This is especially important in light of the trend towards more switches.

Covered versus uncovered self-expandable metal stents for malignant biliary strictures: A meta-analysis and systematic review.

PubMed

Moole, Harsha; Bechtold, Matthew L; Cashman, Micheal; Volmar, Fritz H; Dhillon, Sonu; Forcione, David; Taneja, Deepak; Puli, Srinivas R

2016-09-01

Self-expandable metal stents (SEMS) are used for palliating inoperable malignant biliary strictures. It is unclear if covered metal stents are superior to uncovered metal stents in these patients. We compared clinical outcomes in patients with covered and uncovered stents. Studies using covered and uncovered metallic stents for palliation in patients with malignant biliary stricture were reviewed. Articles were searched in MEDLINE, PubMed, and Ovid journals. Fixed and random effects models were used to calculate the pooled proportions. Initial search identified 1436 reference articles, of which 132 were selected and reviewed. Thirteen studies (n = 2239) for covered and uncovered metallic stents which met the inclusion criteria were included in this analysis. Odds ratio for stent occlusion rates in covered vs. uncovered stents was 0.79 (95 % CI = 0.65 to 0.96). Survival benefit in patients with covered vs. uncovered stents showed the odds ratio to be 1.29 (95 % CI = 0.95 to 1.74). Pooled odds ratio for migration of covered vs. uncovered stents was 9.9 (95 % CI = 4.5 to 22.3). Covered stents seemed to have significantly lesser occlusion rates, increased odds of migration, and increased odds of pancreatitis compared to uncovered stents. There was no statistically significant difference in the survival benefit, overall adverse event rate, and patency period of covered vs. uncovered metal stents in patients with malignant biliary strictures.

Defibrotide: a review on clinical use and future development.

PubMed

Larocca, A; Cavallo, F; Magarotto, V; Rossi, D; Patriarca, F; Boccadoro, M; Palumbo, A

2008-08-01

Defibrotide is a deoxyribonucleic acid derivative that has been developed for the treatment of different vascular disorders. The authors reviewed the literature to give due representation to the spectrum of pharmacological properties and clinical application of this drug, evaluating consolidate and innovative application. The authors used PubMed from November 1982 to December 2007 and meeting abstracts (form American Society of Hematology Annual Meeting) with updated data as the sources for this review and selecting the most relevant papers when two or more articles covered the same point of interest. Defibrotide has been used effectively in the treatment of endothelial complications of allogeneic stem cell transplantation and recent preclinical evidences suggest an antiangiogenic effect and an anticancer activity. Further in vivo and in vitro investigations are needed.

Review of design optimization methods for turbomachinery aerodynamics

NASA Astrophysics Data System (ADS)

Li, Zhihui; Zheng, Xinqian

2017-08-01

In today's competitive environment, new turbomachinery designs need to be not only more efficient, quieter, and ;greener; but also need to be developed at on much shorter time scales and at lower costs. A number of advanced optimization strategies have been developed to achieve these requirements. This paper reviews recent progress in turbomachinery design optimization to solve real-world aerodynamic problems, especially for compressors and turbines. This review covers the following topics that are important for optimizing turbomachinery designs. (1) optimization methods, (2) stochastic optimization combined with blade parameterization methods and the design of experiment methods, (3) gradient-based optimization methods for compressors and turbines and (4) data mining techniques for Pareto Fronts. We also present our own insights regarding the current research trends and the future optimization of turbomachinery designs.

Emerging issues and current trends in assistive technology use 2007-2010: practising, assisting and enabling learning for all.

PubMed

Abbott, Chris; Brown, David; Evett, Lindsay; Standen, Penny

2014-11-01

Following an earlier review in 2007, a further review of the academic literature relating to the uses of assistive technology (AT) by children and young people was completed, covering the period 2007-2011. As in the earlier review, a tripartite taxonomy: technology uses to train or practise, technology uses to assist learning and technology uses to enable learning, was used in order to structure the findings. The key markers for research in this field and during these three years were user involvement, AT on mobile mainstream devices, the visibility of AT, technology for interaction and collaboration, new and developing interfaces and inclusive design principles. The paper concludes by locating these developments within the broader framework of the Digital Divide.

Recent progress in microchip electrophoresis-mass spectrometry.

PubMed

Kitagawa, Fumihiko; Otsuka, Koji

2011-06-25

This review highlights the methodological and instrumental developments in microchip electrophoresis (MCE)-mass spectrometry (MS) from 1997. In MCE-MS, the development of ionization interface is one of the most important issues to realize highly sensitive detection and high separation efficiency. Among several interfaces, electrospray ionization (ESI) has been mainly employed to MCE-MS since a simple structure of the ESI interface is suitable for coupling with the microchips. Although the number of publications is still limited, laser desorption ionization (LDI) interface has also been developed for MCE-MS. The characteristics of the ESI and LDI interfaces applied to the electrophoresis microchips are presented in this review. The scope of applications in MCE-MS covers mainly biogenic compounds such as bioactive amines, peptides, tryptic digests and proteins. This review provides a comprehensive table listing the applications in MCE-MS. Copyright © 2010 Elsevier B.V. All rights reserved.

Endovascular management of iatrogenic cervical internal carotid artery pseudoaneurysm in a 9-year-old child: Case report and literature review.

PubMed

Pinzón, Martín; Lobelo, Nelson Oswaldo; Rodríguez, María Claudia; Villamor, Perla; Otoya, Ana María

2017-04-01

Extracranial internal carotid artery (ICA) pseudoaneurysms are uncommon in the pediatric population and are usually secondary to direct trauma to the vessel. Treatment options include surgery (ligation), anticoagulation therapy and endovascular treatment. Endovascular covered stents have shown good results in adult populations, resulting in occlusion of the aneurysm and preservation of the artery without significant complications. However, there have been only limited reports in the literature reporting endovascular carotid stent placement in the pediatric population. We report a case of a 9-year-old boy patient, who developed a cervical ICA pseudoaneurysm after a parapharyngeal tumor resection. He was successfully treated by primary endovascular covered stent placement. During a follow-up of 6 months the patient has been asymptomatic, without any adverse event. Additionally, a literature review is done. Copyright © 2017 Elsevier B.V. All rights reserved.

The Astrophysics Source Code Library by the numbers

NASA Astrophysics Data System (ADS)

Allen, Alice; Teuben, Peter; Berriman, G. Bruce; DuPrie, Kimberly; Mink, Jessica; Nemiroff, Robert; Ryan, PW; Schmidt, Judy; Shamir, Lior; Shortridge, Keith; Wallin, John; Warmels, Rein

2018-01-01

The Astrophysics Source Code Library (ASCL, ascl.net) was founded in 1999 by Robert Nemiroff and John Wallin. ASCL editors seek both new and old peer-reviewed papers that describe methods or experiments that involve the development or use of source code, and add entries for the found codes to the library. Software authors can submit their codes to the ASCL as well. This ensures a comprehensive listing covering a significant number of the astrophysics source codes used in peer-reviewed studies. The ASCL is indexed by both NASA’s Astrophysics Data System (ADS) and Web of Science, making software used in research more discoverable. This presentation covers the growth in the ASCL’s number of entries, the number of citations to its entries, and in which journals those citations appear. It also discusses what changes have been made to the ASCL recently, and what its plans are for the future.

A review on green trend for oil extraction using subcritical water technology and biodiesel production.

PubMed

Abdelmoez, Weal; Ashour, Eman; Naguib, Shahenaz M

2015-01-01

It became a global agenda to develop clean alternative fuels which were domestically available, environmentally acceptable and technically feasible. Thus, biodiesel was destined to make a substantial contribution to the future energy demands of the domestic and industrial economies. Utilization of the non edible vegetable oils as raw materials for biodiesel production had been handled frequently for the past few years. The oil content of these seeds could be extracted by different oil extraction methods, such as mechanical extraction, solvent extraction and by subcritical water extraction technology SWT. Among them, SWT represents a new promising green extraction method. Therefore this review covered the current used non edible oil seeds for biodiesel production as well as giving a sharp focus on the efficiency of using the SWT as a promising extraction method. In addition the advantages and the disadvantages of the different biodiesel production techniques would be covered.

Nuclear fuels - Present and future

NASA Astrophysics Data System (ADS)

Olander, D.

2009-06-01

The important developments in nuclear fuels and their problems are reviewed and compared with the status of present light-water reactor fuels. The limitations of LWR fuels are reviewed with respect to important recent concerns, namely provision of outlet coolant temperatures high enough for use in H 2 production, destruction of plutonium to eliminate proliferation concerns, and burning of the minor actinides to reduce the waste repository heat load and long-term radiation hazard. In addition to current oxide-based fuel rod designs, the hydride fuel with liquid-metal thermal bonding of the fuel-cladding gap is covered. Finally, two of the most promising Generation IV reactor concepts, the very high temperature reactor and the sodium fast reactor, and the accompanying reprocessing technologies, aqueous-based UREX+1a and pyrometallurgical, are summarized. In all of the topics covered, the thermodynamics involved in the fuel's behavior under irradiation and in the reprocessing schemes are emphasized.

Building a Continental Scale Land Cover Monitoring Framework for Australia

NASA Astrophysics Data System (ADS)

Thankappan, Medhavy; Lymburner, Leo; Tan, Peter; McIntyre, Alexis; Curnow, Steven; Lewis, Adam

2012-04-01

Land cover information is critical for national reporting and decision making in Australia. A review of information requirements for reporting on national environmental indicators identified the need for consistent land cover information to be compared against a baseline. A Dynamic Land Cover Dataset (DLCD) for Australia has been developed by Geoscience Australia and the Australian Bureau of Agriculture and Resource Economics and Sciences (ABARES) recently, to provide a comprehensive and consistent land cover information baseline to enable monitoring and reporting for sustainable farming practices, water resource management, soil erosion, and forests at national and regional scales. The DLCD was produced from the analysis of Enhanced Vegetation Index (EVI) data at 250-metre resolution derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) for the period from 2000 to 2008. The EVI time series data for each pixel was modelled as 12 coefficients based on the statistical, phenological and seasonal characteristics. The time series were then clustered in coefficients spaces and labelled using ancillary information on vegetation and land use at the catchment scale. The accuracy of the DLCD was assessed using field survey data over 25,000 locations provided by vegetation and land management agencies in State and Territory jurisdictions, and by ABARES. The DLCD is seen as the first in a series of steps to build a framework for national land cover monitoring in Australia. A robust methodology to provide annual updates to the DLCD is currently being developed at Geoscience Australia. There is also a growing demand from the user community for land cover information at better spatial resolution than currently available through the DLCD. Global land cover mapping initiatives that rely on Earth observation data offer many opportunities for national and international programs to work in concert and deliver better outcomes by streamlining efforts on development and validation of land cover products. Among the upcoming missions, the Global Monitoring for Environment and Security (GMES) Sentinel-2 satellites are seen as an important source of optical data for updating land cover information in Australia. This paper outlines the DLCD development, key applications that inform nationally significant issues, further work on updating the DLCD that would enable transition to a national land cover monitoring framework, challenges and approaches to delivering land cover information at higher spatial resolutions on a continental scale, and the potential value of data from the Sentinel-2 mission in supporting land cover monitoring in Australia and globally.

39 CFR 233.3 - Mail covers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... transcription, photograph, photocopy or any other facsimile of the image of the outside cover, envelope, wrapper... Postal Inspection Service to transmit mail cover reports directly to the requesting authority. (j) Review...

39 CFR 233.3 - Mail covers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... transcription, photograph, photocopy or any other facsimile of the image of the outside cover, envelope, wrapper... Postal Inspection Service to transmit mail cover reports directly to the requesting authority. (j) Review...

39 CFR 233.3 - Mail covers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... transcription, photograph, photocopy or any other facsimile of the image of the outside cover, envelope, wrapper... Postal Inspection Service to transmit mail cover reports directly to the requesting authority. (j) Review...

39 CFR 233.3 - Mail covers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... transcription, photograph, photocopy or any other facsimile of the image of the outside cover, envelope, wrapper... Postal Inspection Service to transmit mail cover reports directly to the requesting authority. (j) Review...

39 CFR 233.3 - Mail covers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... transcription, photograph, photocopy or any other facsimile of the image of the outside cover, envelope, wrapper... Postal Inspection Service to transmit mail cover reports directly to the requesting authority. (j) Review...

Development of a Memory Game to Improve Knowledge Retention in Preparation for Broad Scope Exams in an Introductory Earth Science Course

NASA Astrophysics Data System (ADS)

Cook, H. M.; Bilsley, N. A.

2015-12-01

As the demand for introductory earth science classes rises at educational institutions, large class sizes place strain on the educator's time and ability to offer extensive project-based assignments. As a result, exams covering a broad spectrum of material are more heavily weighted in students' grades. Students often struggle on the first exam, as they attempt to retain a large amount of information from several different topics, while having no exposure to the type of questions that will be asked. This frequently leads to a large dropout rate early in the academic term, or at least a sense of discouragement and stress among struggling students. To better prepare students for a broad scope exam, a review activity modelled after the traditional Milton Bradley "Memory" game was developed to remind students of what would be covered on the exam, prepare them for the style of questions that may be asked, as well as provide a fun, interactive, and educational activity. The Earth Science Memory Game was developed to have interchangeable sets to cover a broad range of topics and thus also be reusable for the duration of the course. Example games sets presented include, but are not limited to, the scientific method, minerals, rocks, topographic maps, tectonics, geologic structures, volcanoes, and weather. The Earth Science Memory Game not only provides an effective review tool to improve success rates on broad scope exams, but is also customizable by the instructor, reusable, and easily constructed by common office supplies.

Recent developments and directions in printed nanomaterials

NASA Astrophysics Data System (ADS)

Choi, Hyung Woo; Zhou, Tianlei; Singh, Madhusudan; Jabbour, Ghassan E.

2015-02-01

In this review, we survey several recent developments in printing of nanomaterials for contacts, transistors, sensors of various kinds, light-emitting diodes, solar cells, memory devices, and bone and organ implants. The commonly used nanomaterials are classified according to whether they are conductive, semiconducting/insulating or biological in nature. While many printing processes are covered, special attention is paid to inkjet printing and roll-to-roll printing in light of their complexity and popularity. In conclusion, we present our view of the future development of this field.

Formulation of US international energy policies

NASA Astrophysics Data System (ADS)

1980-09-01

To find out how the United States develops international energy policy, GAO reviewed five major energy issues covering the period from early 1977 through 1979. The issues are: vulnerabilities to petroleum supply interruptions; long term national security strategy on imported oil prices; export of U.S. oil and gas production equipment and technology to the Soviety Union; World Bank initiatives to assist in financing oil and gas exploration and development in oil-importing developing countries; and the role of gas imports relative to the nation's future sources of gas.

BET inhibitors in cancer therapeutics: a patent review.

PubMed

Ghoshal, Anirban; Yugandhar, D; Srivastava, Ajay Kumar

2016-01-01

Inhibition of Bromodomain and Extra Terminal (BET) proteins is an emerging approach for developing advanced cancer therapeutics. In 2015, at least thirty patents have been published for developing cancer chemotherapeutics by targeting BET. Currently there are seven small molecule BET inhibitors in various stages of clinical trials for the development of anti-cancer drugs. Important patents focusing on development of BET inhibitors as potential cancer therapeutics published in 2015 have been covered. The reports are presented together with a review of the related structural chemical space. This review mainly focuses on the therapeutic applications, chemical class and structural modifications along with the molecules currently in clinical trials. BET sub-family proteins are one of the emerging targets to develop anti-cancer agents. Although many research groups have demonstrated the rationality of BET inhibition to combat cancer, a detailed molecular study needs to be performed to investigate the affected biological pathways. Selectivity among BET proteins should be kept in mind while developing BET inhibitors. In-silico molecular modelling studies can also provide valuable information for designing selective BET inhibitors towards anti-cancer drug discovery and development.

29 CFR 2204.104 - Proceedings covered.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT IN PROCEEDINGS BEFORE THE OCCUPATIONAL SAFETY AND HEALTH REVIEW... covered are the following proceedings under section 10(c), 29 U.S.C. 659(c), of the OSH Act: (a) Contests...

77 FR 66663 - Agency Information Collection Activities: Proposed Information Collection; Submission for OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

... titled, ``Company-Run Annual Stress Test Reporting Template and Documentation for Covered Institutions... review and clearance. Company-Run Annual Stress Test Reporting Template and Documentation for Covered... savings associations, to conduct annual stress tests \\2\\ and requires the primary financial regulatory...

1999 NASA High-Speed Research Program Aerodynamic Performance Workshop. Volume 2; High Lift

NASA Technical Reports Server (NTRS)

Hahne, David E. (Editor)

1999-01-01

NASA's High-Speed Research Program sponsored the 1999 Aerodynamic Performance Technical Review on February 8-12, 1999 in Anaheim, California. The review was designed to bring together NASA and industry High-Speed Civil Transport (HSCT) Aerodynamic Performance technology development participants in the areas of Configuration Aerodynamics (transonic and supersonic cruise drag prediction and minimization), High Lift, and Flight Controls. The review objectives were to (1) report the progress and status of HSCT aerodynamic performance technology development; (2) disseminate this technology within the appropriate technical communities; and (3) promote synergy among die scientists and engineers working on HSCT aerodynamics. In particular, single and midpoint optimized HSCT configurations, HSCT high-lift system performance predictions, and HSCT simulation results were presented, along with executive summaries for all the Aerodynamic Performance technology areas. The HSR Aerodynamic Performance Technical Review was held simultaneously with the annual review of the following airframe technology areas: Materials and Structures, Environmental Impact, Flight Deck, and Technology Integration. Thus, a fourth objective of the Review was to promote synergy between the Aerodynamic Performance technology area and the other technology areas of the HSR Program. This Volume 2/Part 2 publication covers the tools and methods development session.

3-D Sound for Virtual Reality and Multimedia

NASA Technical Reports Server (NTRS)

Begault, Durand R.; Trejo, Leonard J. (Technical Monitor)

2000-01-01

Technology and applications for the rendering of virtual acoustic spaces are reviewed. Chapter 1 deals with acoustics and psychoacoustics. Chapters 2 and 3 cover cues to spatial hearing and review psychoacoustic literature. Chapter 4 covers signal processing and systems overviews of 3-D sound systems. Chapter 5 covers applications to computer workstations, communication systems, aeronautics and space, and sonic arts. Chapter 6 lists resources. This TM is a reprint of the 1994 book from Academic Press.

Development of an Online Library of Patient-Reported Outcome Measures in Gastroenterology: The GI-PRO Database

PubMed Central

Khanna, Puja; Agarwal, Nikhil; Khanna, Dinesh; Hays, Ron D.; Chang, Lin; Bolus, Roger; Melmed, Gil; Whitman, Cynthia B.; Kaplan, Robert M.; Ogawa, Rikke; Snyder, Bradley; Spiegel, Brennan M.R.

2014-01-01

OBJECTIVES Because gastrointestinal (GI) illnesses can cause physical, emotional, and social distress, patient-reported outcomes (PROs) are used to guide clinical decision making, conduct research, and seek drug approval. It is important to develop a mechanism for identifying, categorizing, and evaluating the over 100 GI PROs that exist. Here we describe a new, National Institutes of Health (NIH)-supported, online PRO clearinghouse—the GI-PRO database. METHODS Using a protocol developed by the NIH Patient-Reported Outcome Measurement Information System (PROMIS®), we performed a systematic review to identify English-language GI PROs. We abstracted PRO items and developed an online searchable item database. We categorized symptoms into content “bins” to evaluate a framework for GI symptom reporting. Finally, we assigned a score for the methodological quality of each PRO represented in the published literature (0–20 range; higher indicates better). RESULTS We reviewed 15,697 titles (κ > 0.6 for title and abstract selection), from which we identified 126 PROs. Review of the PROs revealed eight GI symptom “bins”: (i) abdominal pain, (ii) bloat/gas, (iii) diarrhea, (iv) constipation, (v) bowel incontinence/soilage, (vi) heartburn/reflux, (vii) swallowing, and (viii) nausea/vomiting. In addition to these symptoms, the PROs covered four psychosocial domains: (i) behaviors, (ii) cognitions, (iii) emotions, and (iv) psychosocial impact. The quality scores were generally low (mean 8.88±4.19; 0 (min)−20 (max)). In addition, 51% did not include patient input in developing the PRO, and 41% provided no information on score interpretation. CONCLUSIONS GI PROs cover a wide range of biopsychosocial symptoms. Although plentiful, GI PROs are limited by low methodological quality. Our online PRO library (www.researchcore.org/gipro/) can help in selecting PROs for clinical and research purposes. PMID:24343547

Assessing map accuracy in a remotely sensed, ecoregion-scale cover map

USGS Publications Warehouse

Edwards, T.C.; Moisen, Gretchen G.; Cutler, D.R.

1998-01-01

Landscape- and ecoregion-based conservation efforts increasingly use a spatial component to organize data for analysis and interpretation. A challenge particular to remotely sensed cover maps generated from these efforts is how best to assess the accuracy of the cover maps, especially when they can exceed 1000 s/km2 in size. Here we develop and describe a methodological approach for assessing the accuracy of large-area cover maps, using as a test case the 21.9 million ha cover map developed for Utah Gap Analysis. As part of our design process, we first reviewed the effect of intracluster correlation and a simple cost function on the relative efficiency of cluster sample designs to simple random designs. Our design ultimately combined clustered and subsampled field data stratified by ecological modeling unit and accessibility (hereafter a mixed design). We next outline estimation formulas for simple map accuracy measures under our mixed design and report results for eight major cover types and the three ecoregions mapped as part of the Utah Gap Analysis. Overall accuracy of the map was 83.2% (SE=1.4). Within ecoregions, accuracy ranged from 78.9% to 85.0%. Accuracy by cover type varied, ranging from a low of 50.4% for barren to a high of 90.6% for man modified. In addition, we examined gains in efficiency of our mixed design compared with a simple random sample approach. In regard to precision, our mixed design was more precise than a simple random design, given fixed sample costs. We close with a discussion of the logistical constraints facing attempts to assess the accuracy of large-area, remotely sensed cover maps.

A review of ultraviolet astronomical research with the Copernicus satellite

NASA Technical Reports Server (NTRS)

Snow, T. P., Jr.

1976-01-01

Results of ultraviolet spectrophotometric observations with the satellite Copernicus (OAO-3) are summarized, and are intended to be completely covered through January 1, 1976. Interstellar research recently reviewed elsewhere is not included, although some newer interstellar results are described. A large fraction of the research covered in this review has been carried out by Guest Investigators with Copernicus. A brief description of the spacecraft and its operation is included.

Report planning, preparation and review guide

USGS Publications Warehouse

Moore, J.E.; Aronson, D.A.; Green, J.H.; Puente, Celso

1990-01-01

The guide describes critical steps in the planning, preparation, and review of hydrologic projects and reports. Project and report planning and organization are discussed first. Report writing and guidelines for writing selected parts of the report are covered next. The last topics covered are editorial and technical review. The guide contains examples of good and poor writing, report checklists, and source references to assist authors in the various stages of report preparation.

Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels.

PubMed

de Jong, Bouke; Siewers, Verena; Nielsen, Jens

2012-08-01

Transportation fuels will gradually shift from oil based fuels towards alternative fuel resources like biofuels. Current bioethanol and biodiesel can, however, not cover the increasing demand for biofuels and there is therefore a need for advanced biofuels with superior fuel properties. Novel cell factories will provide a production platform for advanced biofuels. However, deep cellular understanding is required for improvement of current biofuel cell factories. Fast screening and analysis (-omics) methods and metabolome-wide mathematical models are promising techniques. An integrated systems approach of these techniques drives diversity and quantity of several new biofuel compounds. This review will cover the recent technological developments that support improvement of the advanced biofuels 1-butanol, biodiesels and jetfuels. Copyright © 2011 Elsevier Ltd. All rights reserved.

Recovery and purification process development for monoclonal antibody production

PubMed Central

Ma, Junfen; Winter, Charles; Bayer, Robert

2010-01-01

Hundreds of therapeutic monoclonal antibodies (mAbs) are currently in development, and many companies have multiple antibodies in their pipelines. Current methodology used in recovery processes for these molecules are reviewed here. Basic unit operations such as harvest, Protein A affinity chromatography and additional polishing steps are surveyed. Alternative processes such as flocculation, precipitation and membrane chromatography are discussed. We also cover platform approaches to purification methods development, use of high throughput screening methods, and offer a view on future developments in purification methodology as applied to mAbs. PMID:20647768

Pneumocystis jirovecii pneumonia in developing countries*

PubMed Central

De Armas Rodríguez, Y.; Wissmann, G.; Müller, A.L.; Pederiva, M.A.; Brum, M.C.; Brackmann, R.L.; Capó De Paz, V.; Calderón, E.J.

2011-01-01

Pneumocystis pneumonia (PcP) is a serious fungal infection among immunocompromised patients. In developed countries, the epidemiology and clinical spectrum of PcP have been clearly defined and well documented. However, in most developing countries, relatively little is known about the prevalence of pneumocystosis. Several articles covering African, Asian and American countries were reviewed in the present study. PcP was identified as a frequent opportunistic infection in AIDS patients from different geographic regions. A trend to an increasing rate of PcP was apparent in developing countries from 2002 to 2010. PMID:21894262

76 FR 66687 - Purified Carboxymethylcellulose From the Netherlands: Final Results of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... antidumping duty administrative review of purified carboxymethylcellulose (CMC) from the Netherlands, covering...) (Preliminary Results). The merchandise covered by the order is purified CMC, as described in the ``Scope of the... duty order on purified CMC from the Netherlands. See Preliminary Results. The respondent under review...

Nature and Analysis of Chemical Species.

ERIC Educational Resources Information Center

Shuman, Mark S.; Fogleman, Wavell W.

1978-01-01

Presents a literature review of the nature and analysis of chemical species in water, covering publications of 1976-77. This review is concerned with inorganics, and it covers: (1) electrochemical analysis; (2) spectroscopy; (3) neutron activation, radiochemical analysis, and isotope dilution. A list of 262 references is also presented. (HM)

Secondary School Advanced Mathematics, Chapter 8, Systems of Equations. Teacher's Commentary.

ERIC Educational Resources Information Center

Stanford Univ., CA. School Mathematics Study Group.

This manual was designed for use with the last of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered in…

Develop Efficient Leak Proof M1 Abrams Plenum Seal

DTIC Science & Technology

2014-05-07

burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching...ADDRESS. 1 . REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c... 1 Background ................................................................................................................. 6 1.1 Problem

Softball for Boys and Girls. Skills Test Manual.

ERIC Educational Resources Information Center

Rikli, Roberta E., Ed.

The first section of this manual provides information on the history of softball and the development of testing for proficiency in the game. The tests in the manual cover batting, fielding ground balls, overhand throwing, and baserunning. Test norms are listed for males and females at each grade level. A review is included of proper techniques and…

Research on Language Teaching and Learning in Austria (2004-2009)

ERIC Educational Resources Information Center

Dalton-Puffer, Christiane; Faistauer, Renate; Vetter, Eva

2011-01-01

This overview of six years of research on language learning and teaching in Austria covers a period of dynamic development in the field. While all the studies reviewed here illustrate research driven by a combination of local and global concerns and theoretical frameworks, some specific clusters of research interest emerge. The first of these…

Understanding and Managing Learning Disabilities in Adults. Professional Practices in Adult Education and Human Resource Development Series.

ERIC Educational Resources Information Center

Jordan, Dale R.

This book reviews learning disabilities (LD) in adults and makes suggestions for helping adults cope with these disabilities. Each chapter covers a type of learning disability or related syndrome or explains characteristics of the brain. Chapter 1 explains several types of specific learning disabilities that make classroom performance difficult…

Contabilidad Avanzada. Prontuario. Documento de Trabajo (Advanced Accounting. Handbook. Working Document).

ERIC Educational Resources Information Center

Puerto Rico State Dept. of Education, Hato Rey. Area for Vocational and Technical Education.

This advanced accounting handbook is intended for a 2-semester course for 11th-grade students preparing to be accounting clerks. The guide begins with a course description, a list of competencies to be developed, and terminal and enabling objectives. Two outlines based on recommended texts cover the following topics: review of the accounting…

Two new mobile apps for rangeland inventory and monitoring by landowners and land managers

USDA-ARS?s Scientific Manuscript database

Rangeland inventory and monitoring have been transformed during the past 10 years by a number of major innovations. This paper reviews the status of two new mobile apps (LandInfo and LandCover) that are part of a larger “Land-Potential Knowledge System” (LandPKS) that is being developed to capitaliz...

Military Curricula for Vocational & Technical Education. Petroleum Equipment and Technical Operations, QM0142, 19-5.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This subcourse containg lesson assignments, lesson texts, and programmed reviews covers the most frequently used equipment for transporting and storing petroleum products from the time they are purchased until they are consumed by the user. The course is one of a number of military-developed curriculum packages selected for adaptation to…

Towards More Flexibility in Training: A Review of Some Experiences in Rationalizing the Provision of Vocational Qualifications. Employment and Training Papers.

ERIC Educational Resources Information Center

Tchaban, A., Ed.

This document presents five papers, each describing different experiences in the introduction, promotion and implementation of innovative adult training approaches aimed at achieving more flexibility in skill development. An introduction (Anatoli Tchaban) presents background information and a synthesis of the studies covering definitions, concepts…

The Woman Manager in the United States. A Research Analysis and Bibliography.

ERIC Educational Resources Information Center

Brown, Linda Keller

This review essay analyzes the present research on women as managers and executives in business, commerce, and industry in the United States. The nine sections of the essay cover the following topics of potential interest to researchers and businesswomen: the historical contributions of women to the development of management, the social forces…

Assessment of research and development (R and D) needs in LPG safety and environmental control

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeSteese, J.G.

1982-05-01

The report characterizes the LPG industry covering all operations from production to end use, reviews current knowledge of LPG release phenomenology, summarizes the status of current LPG release prevention and control methodology, and identifies any remaining safety and environmental problems and recommends R and D strategies that may mitigate these problems. (ACR)

Need for Nondestructive Evaluation (NDE) in the Detection of Decay in Structures

Treesearch

W. Wayne Wilcox

1991-01-01

Examples of the need for nondestructive and remote sensing technologies for evaluating early stages of decay are presented. The need is critical to develop methods of analyzing internal decay, at the center of large wood members, and decay behind concealing coverings. Current technologies are reviewed and their inadequacies discussed. Acoustic emission and...

Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes. Update 2014.

PubMed

Froestl, Wolfgang; Muhs, Andreas; Pfeifer, Andrea

2014-01-01

Scientists working in the field of Alzheimer's disease and, in particular, cognitive enhancers are very productive. The review on Drugs interacting with Enzymes was accepted in August 2012. However, this field is very dynamic. New potential targets for the treatment of Alzheimer's disease were identified. This update describes drugs interacting with 60 enzymes versus 43 enzymes in the first paper. Some compounds progressed in their development, while many others were discontinued. The present review covers the evolution of research in this field through April 2014.

Cognitive enhancers (Nootropics). Part 1: drugs interacting with receptors. Update 2014.

PubMed

Froestl, Wolfgang; Muhs, Andreas; Pfeifer, Andrea

2014-01-01

Scientists working in the fields of Alzheimer's disease and, in particular, cognitive enhancers are very productive. The review "Cognitive enhancers (nootropics): drugs interacting with receptors" was accepted for publication in July 2012. Since then, new targets for the potential treatment of Alzheimer's disease were identified. This update describes drugs interacting with 42 receptors versus 32 receptors in the first paper. Some compounds progressed in their development, while many others were discontinued. The present review covers the evolution of research in this field through March 2014.

Liquid-Crystal-Enabled Active Plasmonics: A Review

PubMed Central

Si, Guangyuan; Zhao, Yanhui; Leong, Eunice Sok Ping; Liu, Yan Jun

2014-01-01

Liquid crystals are a promising candidate for development of active plasmonics due to their large birefringence, low driving threshold, and versatile driving methods. We review recent progress on the interdisciplinary research field of liquid crystal based plasmonics. The research scope of this field is to build the next generation of reconfigurable plasmonic devices by combining liquid crystals with plasmonic nanostructures. Various active plasmonic devices, such as switches, modulators, color filters, absorbers, have been demonstrated. This review is structured to cover active plasmonic devices from two aspects: functionalities and driven methods. We hope this review would provide basic knowledge for a new researcher to get familiar with the field, and serve as a reference for experienced researchers to keep up the current research trends. PMID:28788515

Disaster mental health preparedness in the community: A systematic review study

PubMed Central

Roudini, Juliet; Khankeh, Hamid Reza; Witruk, Evelin

2017-01-01

The objective of this study was to perform a systematic review of articles that cover aspects of disaster mental health preparedness. This assessment was done by a thorough review and summary of the available studies which provided a considerable background and amplified the gaps in knowledge about community mental health preparedness. By this systematic review, we tried to identify available concept of community mental health preparedness and related tools that communities and individuals will need to prepare for natural disasters. We found there is a lack of mental health preparedness in the majority of countries; valid and reliable tools and context-bound programs should be developed based on the experiences and perceptions of the community. PMID:28680695

Coherent X-ray imaging across length scales

NASA Astrophysics Data System (ADS)

Munro, P. R. T.

2017-04-01

Contemporary X-ray imaging techniques span a uniquely wide range of spatial resolutions, covering five orders of magnitude. The evolution of X-ray sources, from the earliest laboratory sources through to highly brilliant and coherent free-electron lasers, has been key to the development of these imaging techniques. This review surveys the predominant coherent X-ray imaging techniques with fields of view ranging from that of entire biological organs, down to that of biomolecules. We introduce the fundamental principles necessary to understand the image formation for each technique as well as briefly reviewing coherent X-ray source development. We present example images acquired using a selection of techniques, by leaders in the field.

A document review to characterize Atomic International SNAP fuels shipped to INEL 1966--1973

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wahnschaffe, S.D.; Lords, R.E.; Kneff, D.W.

1995-09-01

This report provides the results of a document search and review study to obtain information on the spent fuels for the following six Nuclear Auxiliary Power (SNAP) reactor cores now stored at the Idaho National Engineering Laboratory (INEL): SNAP-2 Experimental Reactor, SNAP-2 Development Reactor, SNAP-10A Ground Test Reactor, SNAP-8 Experimental Reactor, SNAP-8 Development Reactor, and Shield Test Reactor. The report also covers documentation on SNAP fuel materials from four in-pile materials tests: NAA-82-1, NAA-115-2, NAA-117-1, and NAA-121. Pieces of these fuel materials are also stored at INEL as part of the SNAP fuel shipments.

Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review.

PubMed

Aminimoghadamfarouj, Noushin; Nematollahi, Alireza

2017-06-17

Propolis is one of the complex, but valuable, bio-sources for discovering therapeutic compounds. Diterpenes are organic compounds composed of four isoprene units and are known for their biological and pharmacological characteristics, such as antibacterial, anticancer, and anti-inflammatory activities. Recently, advancements have been made in the development of antibacterial and anticancer leads from propolis-isolated diterpenes, and scrutiny of these compounds is being pursued. Thus, this review covers the progress in this arena, with a focus on the chemistry and biological activities of propolis diterpenes. It is anticipated that important information, in a comprehensive and concise manner, will be delivered here for better understanding of natural product drug discovery research.

Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review

PubMed Central

Aminimoghadamfarouj, Noushin; Nematollahi, Alireza

2017-01-01

Propolis is one of the complex, but valuable, bio-sources for discovering therapeutic compounds. Diterpenes are organic compounds composed of four isoprene units and are known for their biological and pharmacological characteristics, such as antibacterial, anticancer, and anti-inflammatory activities. Recently, advancements have been made in the development of antibacterial and anticancer leads from propolis-isolated diterpenes, and scrutiny of these compounds is being pursued. Thus, this review covers the progress in this arena, with a focus on the chemistry and biological activities of propolis diterpenes. It is anticipated that important information, in a comprehensive and concise manner, will be delivered here for better understanding of natural product drug discovery research. PMID:28629133

Science& Technology Review November 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMahon, D

2003-11-01

This issue of Science & Technology Review covers the following topics: (1) We Will Always Need Basic Science--Commentary by Tomas Diaz de la Rubia; (2) When Semiconductors Go Nano--experiments and computer simulations reveal some surprising behavior of semiconductors at the nanoscale; (3) Retinal Prosthesis Provides Hope for Restoring Sight--A microelectrode array is being developed for a retinal prosthesis; (4) Maglev on the Development Track for Urban Transportation--Inductrack, a Livermore concept to levitate train cars using permanent magnets, will be demonstrated on a 120-meter-long test track; and (5) Power Plant on a Chip Moves Closer to Reality--Laboratory-designed fuel processor gives powermore » boost to dime-size fuel cell.« less

AgRISTARS: Foreign commodity production forecasting. Minutes of the annual formal project manager's review, including preliminary technical review reports of FY80 experiments. [wheat/barley and corn/soybean experiments

NASA Technical Reports Server (NTRS)

1980-01-01

The U.S./Canada wheat/barley exploratory experiment is discussed with emphasis on labeling, machine processing using P1A, and the crop calendar. Classification and the simulated aggregation test used in the U.S. corn/soybean exploratory experiment are also considered. Topics covered regarding the foreign commodity production forecasting project include: (1) the acquisition, handling, and processing of both U.S. and foreign agricultural data, as well as meteorological data. The accuracy assessment methodology, multicrop sampling and aggregation technology development, frame development, the yield project interface, and classification for area estimation are also examined.

77 FR 7080 - Changes To Implement Transitional Program for Covered Business Method Patents

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... 0651-AC73 Changes To Implement Transitional Program for Covered Business Method Patents AGENCY: United... covered business method patents to be conducted before the Patent Trial and Appeal Board (Board). These..., Covered Business Method Patent Review Proposed Rules.'' Comments may also be sent by electronic mail...

77 FR 7095 - Transitional Program for Covered Business Method Patents-Definition of Technological Invention

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... 0651-AC75 Transitional Program for Covered Business Method Patents-- Definition of Technological... proceeding for covered business method patents. The provision of the Leahy-Smith America Invents Act will... to the attention of ``Lead Judge Michael Tierney, Covered Business Method Patent Review Proposed...

How to prepare a systematic review of economic evaluations for clinical practice guidelines: database selection and search strategy development (part 2/3).

PubMed

Thielen, F W; Van Mastrigt, Gapg; Burgers, L T; Bramer, W M; Majoie, Hjm; Evers, Smaa; Kleijnen, J

2016-12-01

This article is part of the series "How to prepare a systematic review of economic evaluations (EES) for informing evidence-based healthcare decisions", in which a five-step approach is proposed. Areas covered: This paper focuses on the selection of relevant databases and developing a search strategy for detecting EEs, as well as on how to perform the search and how to extract relevant data from retrieved records. Expert commentary: Thus far, little has been published on how to conduct systematic review EEs. Moreover, reliable sources of information, such as the Health Economic Evaluation Database, have ceased to publish updates. Researchers are thus left without authoritative guidance on how to conduct SR-EEs. Together with van Mastrigt et al. we seek to fill this gap.

Cellulosic Nanomaterials in Food and Nutraceutical Applications: A Review.

PubMed

Khan, Avik; Wen, Yangbing; Huq, Tanzina; Ni, Yonghao

2018-01-10

Cellulosic nanomaterials (CNMs) are organic, green nanomaterials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made these nanomaterials an intriguing prospect for various applications including the food and nutraceutical industry. From the immobilization of various bioactive agents and enzymes, emulsion stabilization, direct food additives, to the development of intelligent packaging systems or pathogen or pH detectors, the potential food related applications for CNMs are endless. Over the past decade, there have been several reviews published covering different aspects of cellulosic nanomaterials, such as processing-structure-property relationship, physical and chemical properties, rheology, extraction, nanocomposites, etc. In this critical review, we have discussed and provided a summary of the recent developments in the utilization of cellulosic nanomaterials in applications related to food and nutraceuticals.

Landsat Thematic Mapper studies of land cover spatial variability related to hydrology

NASA Technical Reports Server (NTRS)

Wharton, S.; Ormsby, J.; Salomonson, V.; Mulligan, P.

1984-01-01

Past accomplishments involving remote sensing based land-cover analysis for hydrologic applications are reviewed. Ongoing research in exploiting the increased spatial, radiometric, and spectral capabilities afforded by the TM on Landsats 4 and 5 is considered. Specific studies to compare MSS and TM for urbanizing watersheds, wetlands, and floodplain mapping situations show that only a modest improvement in classification accuracy is achieved via statistical per pixel multispectral classifiers. The limitations of current approaches to multispectral classification are illustrated. The objectives, background, and progress in the development of an alternative analysis approach for defining inputs to urban hydrologic models using TM are discussed.

Polymer composites for thermoelectric applications.

PubMed

McGrail, Brendan T; Sehirlioglu, Alp; Pentzer, Emily

2015-02-02

This review covers recently reported polymer composites that show a thermoelectric (TE) effect and thus have potential application as thermoelectric generators and Peltier coolers. The growing need for CO2-minimizing energy sources and thermal management systems makes the development of new TE materials a key challenge for researchers across many fields, particularly in light of the scarcity or toxicity of traditional inorganic TE materials based on Te and Pb. Recent reports of composites with inorganic and organic additives in conjugated and insulating polymer matrices are covered, as well as the techniques needed to fully characterize their TE properties. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research requirements to improve reliability of civil helicopters

NASA Technical Reports Server (NTRS)

Dougherty, J. J., III; Barrett, L. D.

1978-01-01

The major reliability problems of the civil helicopter fleet as reported by helicopter operational and maintenance personnel are documented. An assessment of each problem is made to determine if the reliability can be improved by application of present technology or whether additional research and development are required. The reliability impact is measured in three ways: (1) The relative frequency of each problem in the fleet. (2) The relative on-aircraft manhours to repair, associated with each fleet problem. (3) The relative cost of repair materials or replacement parts associated with each fleet problem. The data reviewed covered the period of 1971 through 1976 and covered only turbine engine aircraft.

The Reviewers Reviewed.

ERIC Educational Resources Information Center

LaBorie, Tim; Halperin, Michael

1983-01-01

Reports results of comparison of seven journals which review popular music recordings, including number of reviews, length of reviews, favorable versus unfavorable reviews, reading score, journal subscription price and average review cost, and music styles covered. Ten references are cited. (EJS)

2002 NASA Seal/Secondary Air System Workshop. Volume 1

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M. (Editor); Hendricks, Robert C. (Editor)

2003-01-01

The 2002 NASA Seal/Secondary Air System Workshop covered the following topics: (i) Overview of NASA s perspective of aeronautics and space technology for the 21st century; (ii) Overview of the NASA-sponsored Ultra-Efficient Engine Technology (UEET), Turbine-Based Combined-Cycle (TBCC), and Revolutionary Turbine Accelator (RTA) programs; (iii) Overview of NASA Glenn's seal program aimed at developing advanced seals for NASA's turbomachinery, space propulsion, and reentry vehicle needs; (iv) Reviews of sealing concepts, test results, experimental facilities, and numerical predictions; and (v) Reviews of material development programs relevant to advanced seals development. The NASA UEET and TBCC/RTA program overviews illustrated for the reader the importance of advanced technologies, including seals, in meeting future turbine engine system efficiency and emission goals. For example, the NASA UEET program goals include an 8- to 15-percent reduction in fuel burn, a 15-percent reduction in CO2, a 70-percent reduction in NOx, CO, and unburned hydrocarbons, and a 30-dB noise reduction relative to program baselines. The workshop also covered several programs NASA is funding to investigate advanced reusable space vehicle technologies (X-38) and advanced space ram/scramjet propulsion systems. Seal challenges posed by these advanced systems include high-temperature operation, resiliency at the operating temperature to accommodate sidewall flexing, and durability to last many missions.

[Advance in researches on vegetation cover and management factor in the soil erosion prediction model].

PubMed

Zhang, Yan; Yuan, Jianping; Liu, Baoyuan

2002-08-01

Vegetation cover and land management are the main limiting factors of soil erosion, and quantitative evaluation on the effect of different vegetation on soil erosion is essential to land use and soil conservation planning. The vegetation cover and management factor (C) in the universal soil loss equation (USLE) is an index to evaluate this effect, which has been studied deeply and used widely. However, the C factor study is insufficient in China. In order to strengthen the research of C factor, this paper reviewed the developing progress of C factor, and compared the methods of estimating C value in different USLE versions. The relative studies in China were also summarized from the aspects of vegetation canopy coverage, soil surface cover, and root density. Three problems in C factor study were pointed out. The authors suggested that cropland C factor research should be furthered, and its methodology should be unified in China to represent reliable C values for soil loss prediction and conservation planning.

Wet soil cover applicability and design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunter, F.; Feenstra, S.; Hwang, D.

1996-12-31

As part of a focused feasibility study for the Tyson Superfund site, Daekyoo Hwang, then with ERM, developed a flooding/flushing option. It was not considered a viable option due to concerns over contaminated groundwater control. The concept, however, had several attractive features: control of VOC emissions; the downward movement of water prevents contamination of the overlying clean soil by the upward movement of contaminated soil vapor; and some natural attenuation of the contaminated lagoon area soils. The new concept employs a near saturated soil layer to prevent VOC emission and the downward movement of water to prevent contamination of surfacemore » soil. The wet soil cover became one of five alternatives submitted as part of the focused feasibility study. It was selected as the remedial option for the site by the USEPA. The study was reviewed by the public and they also were positive as to the use of a wet soil cover to control VOC emissions at the site. The wet soil cover is currently being designed by Smith Environmental.« less

Land cover impacts on stream nutrients and fecal coliform in the lower Piedmont of West Georgia

NASA Astrophysics Data System (ADS)

Schoonover, Jon E.; Lockaby, B. Graeme

2006-12-01

SummaryAs urbanization infiltrates into rural areas, stream water quality is expected to decline as a result from increased impervious surface and greater sources for pollutants. Consequently, West Georgia's water quality is threatened by extensive development as well as other land uses such as livestock grazing and silvicultural activity. Maintenance of stream water quality, as land development occurs, is critical for the protection of drinking water and biotic integrity. A 2-phase, watershed-scale study was established to develop relationships among land cover and water quality within western Georgia. During phase 1, nutrient and fecal coliform data were collected within 18 mixed land use watersheds, ranging in size from 500 to 2500 ha. Regression models were developed that related land cover to stream water nutrient and fecal coliform concentrations. Nutrient and fecal coliform concentrations within watersheds having >24% impervious surface (IS) were often higher than those in nonurban watersheds (i.e., <5% IS) during both base flow (N: 1.64 mg/L versus 0.61 mg/L, and FC: 430 versus 120 MPN/100 ml) and storm flow (N: 1.93 mg/L versus 0.36 mg/L, and FC: 1600 versus 167 MPN/100 ml). Fecal coliform bacteria in urbanized areas consistently exceeded the US EPA's review criterion for recreational waters during both base flow and to a greater extent storm flow. During phase 2, regression models were tested based on data from six newly chosen watersheds with similar land use/cover patterns. Lastly, theoretical watersheds, based on land use percentages, were created to illustrate trends in water quality impairment as land development occurs. The models developed from this research could be used to forecast water quality changes under various land use scenarios in the developing Piedmont region of the US.

Nationwide forestry applications program. Analysis of forest classification accuracy

NASA Technical Reports Server (NTRS)

Congalton, R. G.; Mead, R. A.; Oderwald, R. G.; Heinen, J. (Principal Investigator)

1981-01-01

The development of LANDSAT classification accuracy assessment techniques, and of a computerized system for assessing wildlife habitat from land cover maps are considered. A literature review on accuracy assessment techniques and an explanation for the techniques development under both projects are included along with listings of the computer programs. The presentations and discussions at the National Working Conference on LANDSAT Classification Accuracy are summarized. Two symposium papers which were published on the results of this project are appended.

Space station needs, attributes and architectural options study. Briefing material, mid-term review

NASA Technical Reports Server (NTRS)

1982-01-01

User mission requirements and their relationship to the current space transportation system are examined as a means of assuring the infusion of corporate ideas and knowledge in the space station program. Specific tasks include developing strategies to develop user consistency; determine DOD implication and requirements; and foster industry involvement in the space station. Mission alternatives; accrued benefits; program options; system attributes and characteristics; and a recommended plan for space station evolution are covered.

Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft)

EPA Science Inventory

EPA is releasing a draft report "Next Generation Risk Assessment: I...

78 FR 11817 - Purified Carboxymethylcellulose From Finland: Final Results of Antidumping Duty Administrative...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-20

... covers one respondent, CP Kelco Oy and CP Kelco, Inc. (collectively CP Kelco). The period of review (POR..., the Department published the Preliminary Results. This review covers one respondent, CP Kelco. The... Petitioner on September 6, 2012. CP Kelco filed a rebuttal brief on September 11, 2012. We also invited...

A Review of: The Red-cockaded Woodpecker: Surviving in a Fire-Maintained Ecosystem

Treesearch

Kathleen E. Franzreb

2002-01-01

This is a comprehensive treatise on an endangered species that covers both the species' biology and its conservation and recovery. Organized in textbook fashion, the volume includes a review of the most important aspects of Red-cockaded Woodpecker (Picoides borealis) ecology and conservation. The 12 chapters cover this species' taxonomy,...

Editorial

PubMed Central

Wainwright, CL; McGrath, JC

2009-01-01

A themed section in this issue of Br J Pharmacol, on ‘Advances in Nutritional Pharmacology’, provides a valuable and timely update on progress in this area. The value of dietary components to improvement in health and, particularly, to prevention of cardiovascular disease and cancer, is frequently reported in the media and therefore often captures the attention of the wider public. Understanding the pharmacological mechanisms by which nutritional elements confer their health benefits enables us to keep the public informed, but also aids in the identification of new targets for drug development. In recent years there has been significant progress in this field. Four rapidly developing areas are reviewed. Vosper (2009) covers the identification of a receptor for niacin and the subsequent development of selective agonists as lipid lowering agents. Wu-Wong (2009) describes the development of new Vitamin D analogues for the treatment of cardiovascular disease. de Roos et al. (2009) provide detailed insight into how omega-3 fatty acids, also known as longchain n-3 polyunsaturated fatty acids (PUFAs) protect against cardiovascular disease. Zhou et al. (2009) cover the mechanisms underlying the beneficial effects of resveretrol in protection against cancer. These reviews are complimented by three key original articles focusing on endogenous mechanisms of weight control involving endocannabinoids (Izzo et al., 2009), a circulating protein, the soluble leptin receptor (Zhang & Scarpace, 2009) and a treatment, zinc plus cyclo-(His-Pro) (CHP), known to increase insulin metabolism (Song et al., 2009). PMID:19732059

We have got you 'covered': how the meninges control brain development.

PubMed

Siegenthaler, Julie A; Pleasure, Samuel J

2011-06-01

The meninges have traditionally been viewed as specialized membranes surrounding and protecting the adult brain from injury. However, there is increasing evidence that the fetal meninges play important roles during brain development. Through the release of diffusible factors, the meninges influence the proliferative and migratory behaviors of neural progenitors and neurons in the forebrain and hindbrain. Meningeal cells also secrete and organize the pial basement membrane (BM), a critical anchor point for the radially oriented fibers of neuroepithelial stem cells. With its emerging role in brain development, the potential that defects in meningeal development may underlie certain congenital brain abnormalities in humans should be considered. In this review, we will discuss what is known about assembly of the fetal meninges and review the role of meningeal-derived proteins in mouse and human brain development. Copyright © 2011 Elsevier Ltd. All rights reserved.

Translating New Science Into the Drug Review Process

PubMed Central

Rouse, Rodney; Kruhlak, Naomi; Weaver, James; Burkhart, Keith; Patel, Vikram; Strauss, David G.

2017-01-01

In 2011, the US Food and drug Administration (FDA) developed a strategic plan for regulatory science that focuses on developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products. In line with this, the Division of Applied Regulatory Science was created to move new science into the Center for Drug Evaluation and Research (CDER) review process and close the gap between scientific innovation and drug review. The Division, located in the Office of Clinical Pharmacology, is unique in that it performs mission-critical applied research and review across the translational research spectrum including in vitro and in vivo laboratory research, in silico computational modeling and informatics, and integrated clinical research covering clinical pharmacology, experimental medicine, and postmarket analyses. The Division collaborates with Offices throughout CDER, across the FDA, other government agencies, academia, and industry. The Division is able to rapidly form interdisciplinary teams of pharmacologists, biologists, chemists, computational scientists, and clinicians to respond to challenging regulatory questions for specific review issues and for longer-range projects requiring the development of predictive models, tools, and biomarkers to speed the development and regulatory evaluation of safe and effective drugs. This article reviews the Division’s recent work and future directions, highlighting development and validation of biomarkers; novel humanized animal models; translational predictive safety combining in vitro, in silico, and in vivo clinical biomarkers; chemical and biomedical informatics tools for safety predictions; novel approaches to speed the development of complex generic drugs, biosimilars, and antibiotics; and precision medicine. PMID:29568713

Menstrual migraine: a review of current and developing pharmacotherapies for women.

PubMed

Allais, G; Chiarle, Giulia; Sinigaglia, Silvia; Benedetto, Chiara

2018-02-01

Migraine is one of the most common neurological disorders in the general population. It affects 18% of women and 6% of men. In more than 50% of women migraineurs the occurrence of migraine attacks correlates strongly with the perimenstrual period. Menstrual migraine is highly debilitating, less responsive to therapy, and attacks are longer than those not correlated with menses. Menstrual migraine requires accurate evaluation and targeted therapy, that we aim to recommend in this review. Areas covered: This review of the literature provides an overview of currently available pharmacological therapies (especially with triptans, anti-inflammatory drugs, hormonal strategies) and drugs in development (in particular those acting on calcitonin gene-related peptide) for the treatment of acute migraine attacks and the prophylaxis of menstrual migraine. The studies reviewed here were retrieved from the Medline database as of June 2017. Expert opinion: The treatment of menstrual migraine is highly complex. Accurate evaluation of its characteristics is prerequisite to selecting appropriate therapy. An integrated approach involving neurologists and gynecologists is essential for patient management and for continuous updating on new therapies under development.

Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism.

PubMed

Kalyanaraman, Balaraman

2017-08-01

This review of the basics of cancer metabolism focuses on exploiting the metabolic differences between normal and cancer cells. The first part of the review covers the different metabolic pathways utilized in normal cells to generate cellular energy, or ATP, and the glycolytic intermediates required to build the cellular machinery. The second part of the review discusses aerobic glycolysis, or the Warburg effect, and the metabolic reprogramming involving glycolysis, tricarboxylic acid cycle, and glutaminolysis in the context of developing targeted inhibitors in cancer cells. Finally, the selective targeting of cancer mitochondrial metabolism using positively charged lipophilic compounds as potential therapeutics and their ability to mitigate the toxic side effects of conventional chemotherapeutics in normal cells are discussed. I hope this graphical review will be useful in helping undergraduate, graduate, and medical students understand how investigating the basics of cancer cell metabolism could provide new insight in developing potentially new anticancer treatment strategies. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Patent portfolio management: literature review and a proposed model.

PubMed

Conegundes De Jesus, Camila Kiyomi; Salerno, Mario Sergio

2018-05-09

Patents and patent portfolios are gaining attention in the last decades, from the called 'pro-patent era' to the recent billionaire transactions involving patent portfolios. The field is growing in importance, both theoretically and practically and despite having substantial literature on new product development portfolio management, we have not found an article relating this theory to patent portfolios. Areas covered: The paper develops a systematic literature review on patent portfolio management to organize the evolution and tendencies of patent portfolio management, highlighting distinctive features of patent portfolio management. Interview with IP manager of three life sciences companies, including a leading multinational group provided relevant information about patent portfolio management. Expert opinion: Based on the systematic literature review on portfolio management, more specifically, on new product development portfolio theory, and interview the paper proposes the paper proposes a reference model to manage patent portfolios. The model comprises four stages aligned with the three goals of the NPD portfolio management: 1 - Linking strategy of the Company's NPD Portfolio to Patent Portfolio; 2 - Balancing the portfolio in buckets; 3 - Patent Valuation (maximizing valuation); 4 - Regularly reviewing the patent portfolio.

Retrospective on 30 years of nonimaging optics development for solar energy at the University of Chicago

NASA Astrophysics Data System (ADS)

O'Gallagher, Joseph J.

2016-09-01

As the field of nonimaging optics has developed over the last 50 years, among its many applications, the best known and recognized is probably in solar energy. In particular, the approach provides the formalism that allows the design of devices that approach the maximum physically attainable geometric concentration for a given set of optical tolerances. This means that it has the potential to revolutionize the design of solar concentrators. Much of the experimental development and early testing of these concepts was carried out at the University of Chicago by Roland Winston and his colleagues and students. In this presentation, some of many embodiments and variations of the basic Compound Parabolic Concentrator that were developed and tested over a thirty-year period at Chicago are reviewed. Practical and economic aspects of concentrator design for both thermal and photovoltaic applications are discussed. Examples covering the whole range of concentrator applications from simple low-concentration non-tracking designs to ultrahigh-concentration multistage configurations are covered.

Monitoring the Mesoamerican Biological Corridor: A NASA/CCAD Cooperative Research Project

NASA Technical Reports Server (NTRS)

Sever, Thomas; Irwin, Daniel; Sader, Steven A.; Saatchi, Sassan

2004-01-01

To foster scientific cooperation under a Memorandum of Understanding between NASA and the Central American countries, the research project developed regional databases to monitor forest condition and environmental change throughout the region. Of particular interest is the Mesoamerican Biological Corridor (MBC), a chain of protected areas and proposed conservation areas that will link segments of natural habitats in Central America from the borders of northern Columbia to southern Mexico. The first and second year of the project focused on the development of regional satellite databases (JERS-IC, MODIS, and Landsat-TM), training of Central American cooperators and forest cover and change analysis. The three regional satellite mosaics were developed and distributed on CD-ROM to cooperators and regional outlets. Four regional remote sensing training courses were conducted in 3 countries including participants from all 7 Central American countries and Mexico. In year 3, regional forest change assessment in reference to Mesoamerican Biological Corridor was completed and land cover maps (from Landsat TM) were developed for 7 Landsat scenes and accuracy assessed. These maps are being used to support validation of MODIS forest/non forest maps and to examine forest fragmentation and forest cover change in selected study sites. A no-cost time extension (2003-2004) allowed the completion of an M.S. thesis by a Costa Rican student and preparation of manuscripts for future submission to peer-reviewed outlets. Proposals initiated at the end of the project have generated external funding from the U.S. Forest Service (to U. Maine), NASA-ESSF (Oregon State U.) and from USAID and EPA (to NASA-MSFC-GHCC) to test MODIS capabilities to detect forest change; conduct literature review on biomass estimation and carbon stocks and develop a regional remote sensing monitoring center in Central America. The success of the project has led to continued cooperation between NASA, other federal agencies, and scientists from all seven Central American Countries (see SERVIR web site for this ongoing work - servir.nsstc.nasa.gov).

Information Services; A Survey of the History and Present Status of the Field. MOREL Regional Information System for Educators.

ERIC Educational Resources Information Center

Grimes, George

This document is one of a series describing the background, functions, and utilization of the Regional Information System (RIS) developed by the Michigan-Ohio Regional Educational Laboratory (MOREL). The continuing history of the field of librarianship and information services is reviewed in this report. The first part covers ancient times to the…

Heat Capacity of Room-Temperature Ionic Liquids: A Critical Review

NASA Astrophysics Data System (ADS)

Paulechka, Yauheni U.

2010-09-01

Experimental data on heat capacity of room-temperature ionic liquids in the liquid state were compiled and critically evaluated. The compilation contains data for 102 aprotic ionic liquids from 63 literature references and covers the period of time from 1998 through the end of February 2010. Parameters of correlating equations for temperature dependence of the heat capacities were developed.

Just Another Gibbs Sampler (JAGS): Flexible Software for MCMC Implementation

ERIC Educational Resources Information Center

Depaoli, Sarah; Clifton, James P.; Cobb, Patrice R.

2016-01-01

A review of the software Just Another Gibbs Sampler (JAGS) is provided. We cover aspects related to history and development and the elements a user needs to know to get started with the program, including (a) definition of the data, (b) definition of the model, (c) compilation of the model, and (d) initialization of the model. An example using a…

Curriculum for Development: Analysis and Review of Processes, Products and Outcomes. Final Report: Sub-Regional Curriculum Workshop (Colombo, Sri Lanka, October 1-30, 1976).

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and Oceania.

Presenting proceedings and materials covered at an Asian curriculum workshop involving 15 participants from 7 countries (Afghanistan, Bangladesh, Indonesia, Malaysia, the Philippines, India, and Sri Lanka), this document includes: a discussion of criteria for curriculum analysis re: health education and nutrition instruction for grades 6-10; a…

An Annotated Bibliography of Current Literature on the Mentoring of Teachers: Collegial Mentoring Promotes Dual Professional Growth.

ERIC Educational Resources Information Center

Harper, Sheryll Lynch

This study reviews current research on teacher mentors. Mentoring is defined as teacher-to-teacher coaching or counseling. The annotated bibliography covers articles that deal with: (1) descriptions and definitions of mentors; (2) mentoring as a vehicle used in teacher induction programs; and (3) the value of mentoring as a staff development tool.…

75 FR 19613 - First Administrative Review of Sodium Hexametaphosphate from the People's Republic of China...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-15

... hexametaphosphate without regard to chain length i.e., whether regular or long chain. The product covered by this... countries comparable to the PRC in terms of economic development. See July 6, 2009, Letter to All Interested... the date on which the parties agree upon all substantive terms of the sale. This normally includes the...

The Foundation and Development of Computer Assisted Instruction in the Field of Reading from Its Inception to the Present.

ERIC Educational Resources Information Center

Zuberman, Lea K.

This critical review and evaluation of the literature covers the field of computer assisted instruction (CAI) and reading from its inception to the present day. Seventeen research studies are discussed as well as four surveys of previous research in this field. Major issues addressed include the effectiveness of CAI and computer managed…

Social aspects of automation: Some critical insights

NASA Astrophysics Data System (ADS)

Nouzil, Ibrahim; Raza, Ali; Pervaiz, Salman

2017-09-01

Sustainable development has been recognized globally as one of the major driving forces towards the current technological innovations. To achieve sustainable development and attain its associated goals, it is very important to properly address its concerns in different aspects of technological innovations. Several industrial sectors have enjoyed productivity and economic gains due to advent of automation technology. It is important to characterize sustainability for the automation technology. Sustainability is key factor that will determine the future of our neighbours in time and it must be tightly wrapped around the double-edged sword of technology. In this study, different impacts of automation have been addressed using the ‘Circles of Sustainability’ approach as a framework, covering economic, political, cultural and ecological aspects and their implications. A systematic literature review of automation technology from its inception is outlined and plotted against its many outcomes covering a broad spectrum. The study is more focused towards the social aspects of the automation technology. The study also reviews literature to analyse the employment deficiency as one end of the social impact spectrum. On the other end of the spectrum, benefits to society through technological advancements, such as the Internet of Things (IoT) coupled with automation are presented.

NASA Metrology and Calibration, 1980

NASA Technical Reports Server (NTRS)

1981-01-01

The proceedings of the fourth annual NASA Metrology and Calibration Workshop are presented. This workshop covered (1) review and assessment of NASA metrology and calibration activities by NASA Headquarters, (2) results of audits by the Office of Inspector General, (3) review of a proposed NASA Equipment Management System, (4) current and planned field center activities, (5) National Bureau of Standards (NBS) calibration services for NASA, (6) review of NBS's Precision Measurement and Test Equipment Project activities, (7) NASA instrument loan pool operations at two centers, (8) mobile cart calibration systems at two centers, (9) calibration intervals and decals, (10) NASA Calibration Capabilities Catalog, and (11) development of plans and objectives for FY 1981. Several papers in this proceedings are slide presentations only.

Atomic spectrometry update - atomic mass spectrometry.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bacon, J.; Crain, J. S.; McMahon, A. W.

The MS and XRF updates have been published together since their introduction in 1988. In the last few years, however, the two sections have been prepared independently of each other and it therefore seemed appropriate to publish the two sections separately. With effect from this issue, the MS Update will appear in the October issue of JAAS and the XRF Update in the November issue. The format used for the MS section is broadly similar to that used last year, with some additional sub-headings. This Update is intended to cover all atomic and stable isotopic MS techniques, but not thosemore » used in studies of fundamental nuclear physics and exotic nuclei far from stability. Also excluded are those reports in which MS is used as a tool in the study of molecular processes and of gaseous components. the review is based on critical selection of developments in instrumentation and methodology, notable for their innovation, originality or achievement of significant advances, and is not intended to be comprehensive in its coverage. Conference papers are only included if they contain enough information to show they meet these criteria, and our policy in general remains one of waiting for a development to appear in a full paper before inclusion in the review. a similar policy applies to foreign language papers unlikely to reach a wide audience. Routine applications of atomic MS are not included in this Update and the reader is referred to the Updates on Industrial Analysis: Metals, Chemicals and Advanced Materials (96/416), Environmental Analysis (96/1444) and Clinical and Biological Materials, Food and Beverages (96/2479). Also excluded are those applications, even if not routine, which use atomic spectroscopy as a tool for the study of a non-atomic property, for example, the use of stable isotope labeling of carbon or nitrogen in biomolecules in metabolic studies. There have been few general reviews on atomic MS of note in the period covered by this update. That of Colodner et al.(95/3890) gave a general review of ion sources, in particular GDMS, ICP-MS, SIMS and TIMS, and that of Blades (95/2568 and 95/3077) was a very general overview of some of the techniques covered in this Update. The review of the literature in the period covered by this Update reveals strong advances in all areas, with a continuing push to achieve better analyses on smaller samples and in less time. Most advances generally require more sophisticated instrumentation, improved sample preparation methods or new methods of sample introduction. This is typified by advances in ICP-MS, which see considerable emphasis on sample introduction techniques and a move towards magnetic sector instruments. Most applications of ICP-MS are now highly routine. There is still, however, a desire to achieve affordable analysis with simplified and cost-effective instruments, as illustrated by the development of mobile, in-situ isotope MS for environmental studies.« less

In Silico Models of Aerosol Delivery to the Respiratory Tract – Development and Applications

PubMed Central

Longest, P. Worth; Holbrook, Landon T.

2011-01-01

This review discusses the application of computational models to simulate the transport and deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to deposition within the respiratory tract. Traditional one-dimensional (1-D) whole-lung models are discussed briefly followed by a more in-depth review of three-dimensional (3-D) computational fluid dynamics (CFD) simulations. The review of CFD models is organized into sections covering transport and deposition within the inhaler device, the extrathoracic (oral and nasal) region, conducting airways, and alveolar space. For each section, a general review of significant contributions and advancements in the area of simulating pharmaceutical aerosols is provided followed by a more in-depth application or case study that highlights the challenges, utility, and benefits of in silico models. Specific applications presented include the optimization of an existing spray inhaler, development of charge-targeted delivery, specification of conditions for optimal nasal delivery, analysis of a new condensational delivery approach, and an evaluation of targeted delivery using magnetic aerosols. The review concludes with recommendations on the need for more refined model validations, use of a concurrent experimental and CFD approach for developing aerosol delivery systems, and development of a stochastic individual path (SIP) model of aerosol transport and deposition throughout the respiratory tract. PMID:21640772

Review of analytical methods for the quantification of iodine in complex matrices.

PubMed

Shelor, C Phillip; Dasgupta, Purnendu K

2011-09-19

Iodine is an essential element of human nutrition. Nearly a third of the global population has insufficient iodine intake and is at risk of developing Iodine Deficiency Disorders (IDD). Most countries have iodine supplementation and monitoring programs. Urinary iodide (UI) is the biomarker used for epidemiological studies; only a few methods are currently used routinely for analysis. These methods either require expensive instrumentation with qualified personnel (inductively coupled plasma-mass spectrometry, instrumental nuclear activation analysis) or oxidative sample digestion to remove potential interferences prior to analysis by a kinetic colorimetric method originally introduced by Sandell and Kolthoff ~75 years ago. The Sandell-Kolthoff (S-K) method is based on the catalytic effect of iodide on the reaction between Ce(4+) and As(3+). No available technique fully fits the needs of developing countries; research into inexpensive reliable methods and instrumentation are needed. There have been multiple reviews of methods used for epidemiological studies and specific techniques. However, a general review of iodine determination on a wide-ranging set of complex matrices is not available. While this review is not comprehensive, we cover the principal developments since the original development of the S-K method. Copyright © 2011 Elsevier B.V. All rights reserved.

Digital Architecture Planning Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oxstrand, Johanna Helene; Al Rashdan, Ahmad Yahya Mohammad; Bly, Aaron Douglas

As part of the U.S. Department of Energy’s Light Water Reactor Sustainability Program, the Digital Architecture (DA) Project focuses on providing a model that nuclear utilities can refer to when planning deployment of advanced technologies. The digital architecture planning model (DAPM) is the methodology for mapping power plant operational and support activities into a DA that unifies all data sources needed by the utilities to operate their plants. The DA is defined as a collection of information technology capabilities needed to support and integrate a wide spectrum of real-time digital capabilities for performance improvements of nuclear power plants. DA canmore » be thought of as integration of the separate instrumentation and control and information systems already in place in nuclear power plants, which are brought together for the purpose of creating new levels of automation in plant work activities. A major objective in DAPM development was to survey all key areas that needed to be reviewed in order for a utility to make knowledgeable decisions regarding needs and plans to implement a DA at the plant. The development was done in two steps. First, researchers surveyed the nuclear industry in order to learn their near-term plans for adopting new advanced capabilities and implementing a network (i.e., wireless and wire) infrastructure throughout the plant, including the power block. Secondly, a literature review covering regulatory documents, industry standards, and technical research reports and articles was conducted. The objective of the review was to identify key areas to be covered by the DAPM, which included the following: 1. The need for a DA and its benefits to the plant 2. Resources required to implement the DA 3. Challenges that need to be addressed and resolved to implement the DA 4. Roles and responsibilities of the DA implementation plan. The DAPM was developed based on results from the survey and the literature review. Model development, including the survey results and conclusions made about the key areas during the literature review, are described in this report.« less

Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs

PubMed Central

Pierce, Christopher G.; Lopez-Ribot, Jose L.

2014-01-01

Introduction Targeting pathogenetic mechanisms rather than essential processes represents a very attractive alternative for the development of new antibiotics. This may be particularly important in the case of antimycotics, due to the urgent need for novel antifungal drugs and the paucity of selective fungal targets. The opportunistic pathogenic fungus Candida albicans is the main etiological agent of candidiasis, the most common human fungal infection. These infections carry unacceptably high mortality rates, a clear reflection of the many shortcomings of current antifungal therapy, including the limited armamentarium of antifungal agents, their toxicity, and the emergence of resistance. Moreover the antifungal pipeline is mostly dry. Areas covered This review covers some of the most recent progress towards understanding C. albicans pathogenetic processes and how to harness this information for the development of anti-virulence agents. The two principal areas covered are filamentation and biofilm formation, as C. albicans pathogenicity is intimately linked to its ability to undergo morphogenetic conversions between yeast and filamentous morphologies and to its ability to form biofilms. Expert opinion We argue that filamentation and biofilm formation represent high value targets, yet clinically unexploited, for the development of novel anti-virulence approaches against candidiasis. Although this has proved a difficult task despite increasing understanding at the molecular level of C. albicans virulence, we highlight new opportunities and prospects for antifungal drug development targeting these two important biological processes. PMID:23738751

DNA Aptamer Technology for Personalized Medicine

PubMed Central

Xing, Hang; Hwang, Kevin; Li, Ji; Torabi, Seyed-Fakhreddin; Lu, Yi

2014-01-01

This review highlights recent progress in developing DNA aptamers for personalized medicine, with more focus on in vivo studies for potential clinical applications. Examples include design of aptamers in combination with DNA nanostructures, nanomaterials, or microfluidic devices as diagnostic probes or therapeutic agents for cancers and other diseases. The use of aptamers as targeting agents in drug delivery is also covered. The advantages and future directions of such DNA aptamer-based technology for the continued development of personalized medicine are discussed. PMID:24791224

Anaesthesia in the obese child.

PubMed

Philippi-Höhne, Claudia

2011-03-01

The incidence of childhood obesity ranges today from approximately 8% to 17%, and is an increasing issue in developed and developing countries. This disease will become increasingly significant in paediatric anaesthesia. Obese children not only have anaesthesia-relevant co-existing diseases, that are, asthma and hypertension, but also have a higher incidence of anaesthesia-related complication. This review covers current definition and some epidemiology of childhood obesity. It summarises potential co-morbidities and provides details for preoperative evaluation, anaesthetic management and prevention of perioperative complications.

The Information Science Experiment System - The computer for science experiments in space

NASA Technical Reports Server (NTRS)

Foudriat, Edwin C.; Husson, Charles

1989-01-01

The concept of the Information Science Experiment System (ISES), potential experiments, and system requirements are reviewed. The ISES is conceived as a computer resource in space whose aim is to assist computer, earth, and space science experiments, to develop and demonstrate new information processing concepts, and to provide an experiment base for developing new information technology for use in space systems. The discussion covers system hardware and architecture, operating system software, the user interface, and the ground communication link.

The Pacific Community Concept. Proposals for Further Development and Co-Operation between Countries of the Pacific Basin and Reaction to Such Proposals by Pacific Basin Countries. A Select Bibliography. Development of Resource Sharing Networks. Networks Study No. 14.

ERIC Educational Resources Information Center

National Library of Australia, Canberra.

As part of its statutory duty to foster international cooperation, the National Library of Australia has produced this annotated bibliography based on a review of material published since 1968 on the Pacific Community Concept or cooperation between countries in the Pacific Basin area of Asia and Oceania. The 159 items listed cover the following…

The present status and the future of missile aerodynamics

NASA Technical Reports Server (NTRS)

Nielsen, Jack N.

1989-01-01

Recent developments in the state of the art in missile aerodynamics are reviewed. Among the subjects covered are: (1) Tri-service/NASA data base, (2) wing-body interference, (3) nonlinear controls, (4) hypersonic transition, (5) vortex interference, (6) airbreathers, supersonic inlets, (7) store separation problems, (8) correlation of missile data, (9) CFD codes for complete configurations, (10) engineering prediction methods, and (11) future configurations. Suggestions are made for future research and development to advance the state of the art of missile aerodynamics.

The present status and the future of missile aerodynamics

NASA Technical Reports Server (NTRS)

Nielsen, Jack N.

1988-01-01

Some recent developments in the state of the art in missile aerodynamics are reviewed. Among the subjects covered are: (1) tri-service/NASA data base, (2) wing-body interference, (3) nonlinear controls, (4) hypersonic transition, (5) vortex interference, (6) airbreathers, supersonic inlets, (7) store separation problems, (8) correlation of missile data, (9) CFD codes for complete configurations, (10) engineering prediction methods, and (11) future configurations. Suggestions are made for future research and development to advance the state of the art of missile aerodynamics.

Orchestrating high-throughput genomic analysis with Bioconductor

PubMed Central

Huber, Wolfgang; Carey, Vincent J.; Gentleman, Robert; Anders, Simon; Carlson, Marc; Carvalho, Benilton S.; Bravo, Hector Corrada; Davis, Sean; Gatto, Laurent; Girke, Thomas; Gottardo, Raphael; Hahne, Florian; Hansen, Kasper D.; Irizarry, Rafael A.; Lawrence, Michael; Love, Michael I.; MacDonald, James; Obenchain, Valerie; Oleś, Andrzej K.; Pagès, Hervé; Reyes, Alejandro; Shannon, Paul; Smyth, Gordon K.; Tenenbaum, Dan; Waldron, Levi; Morgan, Martin

2015-01-01

Bioconductor is an open-source, open-development software project for the analysis and comprehension of high-throughput data in genomics and molecular biology. The project aims to enable interdisciplinary research, collaboration and rapid development of scientific software. Based on the statistical programming language R, Bioconductor comprises 934 interoperable packages contributed by a large, diverse community of scientists. Packages cover a range of bioinformatic and statistical applications. They undergo formal initial review and continuous automated testing. We present an overview for prospective users and contributors. PMID:25633503

Development of an Ocular and Craniofacial Trauma Treatment Training System

DTIC Science & Technology

2013-08-01

Craniofacial Trauma Treatment Training System PRINCIPAL INVESTIGATOR: Mark P. Ottensmeyer, Ph.D. CONTRACTING ORGANIZATION: Massachusetts...Annual 3. DATES COVERED 11 July 2012 – 10 July 2013 4. TITLE AND SUBTITLE Development of an Ocular and Craniofacial Trauma Treatment Training System...15    Review of  treatment  modes and potential error modes to be detected ................... 15 2.3.2.a.   Implement  improvements  for  upgraded

Potential Relationships Between Urban Development and the Trophic Status of Tampa Bay Tributaries and Lake Thonotosassa, Further the Potential Effect on Public Health

NASA Technical Reports Server (NTRS)

MorenoMadrinan, Max J.; Allhamdan, Mohammad; Rickman, Douglas L.; Estes, Maury

2010-01-01

This slide presentation reviews the use of remote sensing to monitor the relationships between the urban development and water quality in Tampa Bay and the tributaries. It examines the changes in land cover/land use (LU/LC) and the affects that this change has on the water quality of Tampa Bay, Lake Thonotosassa and the tributaries, and that shows the ways that these changes can be estimated with remote sensing.

Quality analysis, classification, and authentication of liquid foods by near-infrared spectroscopy: A review of recent research developments.

PubMed

Wang, Lu; Sun, Da-Wen; Pu, Hongbin; Cheng, Jun-Hu

2017-05-03

Nowadays, near-infrared spectroscopy (NIR) has become one of the most efficient and advanced techniques for analysis of food products. Many relevant researches have been conducted in this regard. However, no reviews about the applications of NIR for liquid food analysis are reported. Therefore, this review summarizes the recent research developments of NIR technology in the field of liquid foods, focusing on the detection of quality attributes of various liquid foods, including alcoholic beverages (red wines, rice wines, and beer), nonalcoholic beverages (juice, fruit vinegars, coffee beverages, and cola beverages), dairy products (milk and yogurt), and oils (vegetable, camellia, peanut, and virgin olive oils and frying oil). In addition, the classification and authentication detection of adulteration are also covered. It is hoped that the current paper can serve as a reference source for the future liquid food analysis by NIR techniques.

TOPICAL REVIEW: The restaurant at the end of the random walk: recent developments in the description of anomalous transport by fractional dynamics

NASA Astrophysics Data System (ADS)

Metzler, Ralf; Klafter, Joseph

2004-08-01

Fractional dynamics has experienced a firm upswing during the past few years, having been forged into a mature framework in the theory of stochastic processes. A large number of research papers developing fractional dynamics further, or applying it to various systems have appeared since our first review article on the fractional Fokker-Planck equation (Metzler R and Klafter J 2000a, Phys. Rep. 339 1-77). It therefore appears timely to put these new works in a cohesive perspective. In this review we cover both the theoretical modelling of sub- and superdiffusive processes, placing emphasis on superdiffusion, and the discussion of applications such as the correct formulation of boundary value problems to obtain the first passage time density function. We also discuss extensively the occurrence of anomalous dynamics in various fields ranging from nanoscale over biological to geophysical and environmental systems.

Mortality, morbidity and health in developed societies: a review of data sources.

PubMed

Wunsch, Guillaume; Gourbin, Catherine

2018-01-01

The purpose of this paper is to review the major sources of data on mortality, morbidity and health in Europe and in other developed regions in order to examine their potential for analysing mortality and morbidity levels and trends. The review is primarily focused on routinely collected information covering a whole country. No attempt is made to draw up an inventory of sources by country; the paper deals instead with the pros and cons of each source for mortality and morbidity studies in demography. While each source considered separately can already yield useful, though partial, results, record linkage among data sources can significantly improve the analysis. Record linkage can also lead to the detection of possible causal associations that could eventually be confirmed. More generally, Big Data can reveal changing mortality and morbidity trends and patterns that could lead to preventive measures being taken rather than more costly curative ones.

Occupational safety and health management in the construction industry: a review.

PubMed

Jaafar, Mohd Hafiidz; Arifin, Kadir; Aiyub, Kadaruddin; Razman, Muhammad Rizal; Ishak, Muhammad Izzuddin Syakir; Samsurijan, Mohamad Shaharudin

2017-09-11

The construction industry plays a significant role in contributing to the economy and development globally. During the process of construction, various hazards coupled with the unique nature of the industry contribute to high fatality rates. This review refers to previous published studies and related Malaysian legislation documents. Four main elements consisting of human, worksite, management and external elements which cause occupational accidents and illnesses were identified. External and management elements are the underlying causes contributing to occupational safety and health (OSH), while human and worksite elements are more apparent causes of occupational accidents and illnesses. An effective OSH management approach is required to contain all hazards at construction sites. An approach to OSH management constructed by elements of policy, process, personnel and incentive developed in previous work is explored. Changes to the sub-elements according to previous studies and the related Malaysian legislation are also covered in this review.

Road vehicle emission factors development: A review

NASA Astrophysics Data System (ADS)

Franco, Vicente; Kousoulidou, Marina; Muntean, Marilena; Ntziachristos, Leonidas; Hausberger, Stefan; Dilara, Panagiota

2013-05-01

Pollutant emissions need to be accurately estimated to ensure that air quality plans are designed and implemented appropriately. Emission factors (EFs) are empirical functional relations between pollutant emissions and the activity that causes them. In this review article, the techniques used to measure road vehicle emissions are examined in relation to the development of EFs found in emission models used to produce emission inventories. The emission measurement techniques covered include those most widely used for road vehicle emissions data collection, namely chassis and engine dynamometer measurements, remote sensing, road tunnel studies and portable emission measurements systems (PEMS). The main advantages and disadvantages of each method with regards to emissions modelling are presented. A review of the ways in which EFs may be derived from test data is also performed, with a clear distinction between data obtained under controlled conditions (engine and chassis dynamometer measurements using standard driving cycles) and measurements under real-world operation.

Protein Crystallography in Vaccine Research and Development.

PubMed

Malito, Enrico; Carfi, Andrea; Bottomley, Matthew J

2015-06-09

The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable success stories. However, it is less well-known that structural biology has emerged as a major tool for the design of novel vaccine antigens. Here, we review the important contributions that protein crystallography has made so far to vaccine research and development. We discuss several examples of the crystallographic characterization of vaccine antigen structures, alone or in complexes with ligands or receptors. We cover the critical role of high-resolution epitope mapping by reviewing structures of complexes between antigens and their cognate neutralizing, or protective, antibody fragments. Most importantly, we provide recent examples where structural insights obtained via protein crystallography have been used to design novel optimized vaccine antigens. This review aims to illustrate the value of protein crystallography in the emerging discipline of structural vaccinology and its impact on the rational design of vaccines.

Protein Crystallography in Vaccine Research and Development

PubMed Central

Malito, Enrico; Carfi, Andrea; Bottomley, Matthew J.

2015-01-01

The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable success stories. However, it is less well-known that structural biology has emerged as a major tool for the design of novel vaccine antigens. Here, we review the important contributions that protein crystallography has made so far to vaccine research and development. We discuss several examples of the crystallographic characterization of vaccine antigen structures, alone or in complexes with ligands or receptors. We cover the critical role of high-resolution epitope mapping by reviewing structures of complexes between antigens and their cognate neutralizing, or protective, antibody fragments. Most importantly, we provide recent examples where structural insights obtained via protein crystallography have been used to design novel optimized vaccine antigens. This review aims to illustrate the value of protein crystallography in the emerging discipline of structural vaccinology and its impact on the rational design of vaccines. PMID:26068237

Towards an Electronic Dog Nose: Surface Plasmon Resonance Immunosensor for Security and Safety

PubMed Central

Onodera, Takeshi; Toko, Kiyoshi

2014-01-01

This review describes an “electronic dog nose” based on a surface plasmon resonance (SPR) sensor and an antigen–antibody interaction for security and safety. We have concentrated on developing appropriate sensor surfaces for the SPR sensor for practical use. The review covers different surface fabrications, which all include variations of a self-assembled monolayer containing oligo(ethylene glycol), dendrimer, and hydrophilic polymer. We have carried out detection of explosives using the sensor surfaces. For the SPR sensor to detect explosives, the vapor or particles of the target substances have to be dissolved in a liquid. Therefore, we also review the development of sampling processes for explosives, and a protocol for the measurement of explosives on the SPR sensor in the field. Additionally, sensing elements, which have the potential to be applied for the electronic dog nose, are described. PMID:25198004

A review of genomic data warehousing systems.

PubMed

Triplet, Thomas; Butler, Gregory

2014-07-01

To facilitate the integration and querying of genomics data, a number of generic data warehousing frameworks have been developed. They differ in their design and capabilities, as well as their intended audience. We provide a comprehensive and quantitative review of those genomic data warehousing frameworks in the context of large-scale systems biology. We reviewed in detail four genomic data warehouses (BioMart, BioXRT, InterMine and PathwayTools) freely available to the academic community. We quantified 20 aspects of the warehouses, covering the accuracy of their responses, their computational requirements and development efforts. Performance of the warehouses was evaluated under various hardware configurations to help laboratories optimize hardware expenses. Each aspect of the benchmark may be dynamically weighted by scientists using our online tool BenchDW (http://warehousebenchmark.fungalgenomics.ca/benchmark/) to build custom warehouse profiles and tailor our results to their specific needs.

Hawaii Geothermal Project annotated bibliography: Biological resources of the geothermal subzones, the transmission corridors and the Puna District, Island of Hawaii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, S.E.; Burgett, J.M.

1993-10-01

Task 1 of the Hawaii Geothermal Project Interagency Agreement between the Fish and Wildlife Service and the Department of Energy-Oak Ridge National Laboratory (DOE) includes an annotated bibliography of published and unpublished documents that cover biological issues related to the lowland rain forest in Puna, adjacent areas, transmission corridors, and in the proposed Hawaii Geothermal Project (HGP). The 51 documents reviewed in this report cover the main body of biological information for these projects. The full table of contents and bibliography for each document is included along with two copies (as requested in the Interagency Agreement) of the biological sectionsmore » of each document. The documents are reviewed in five main categories: (1) geothermal subzones (29 documents); (2) transmission cable routes (8 documents); (3) commercial satellite launching facility (Spaceport; 1 document); (4) manganese nodule processing facility (2 documents); (5) water resource development (1 document); and (6) ecosystem stability and introduced species (11 documents).« less

Coastal aquaculture development in Bangladesh: unsustainable and sustainable experiences.

PubMed

Azad, A Kalam; Jensen, Kathe R; Lin, C Kwei

2009-10-01

Coastal aquaculture in Bangladesh consists mainly of two shrimp species (Penaeus monodon and Macrobrachium rosenbergii). Currently, there are about 16,237 marine shrimp (P. monodon) farms covering 148,093 ha and 36,109 fresh water shrimp (M. rosenbergii) farms covering 17,638 ha coastal area. More than 0.7 million people are employed in the farmed shrimp sector and in 2005-2006 the export value of shrimp was 403.5 million USD. Thus, coastal aquaculture contributes significantly to rural employment and economy but this is overshadowed by negative social and ecological impacts. This article reviews the key issues, constraints and opportunities of sustainable shrimp farming. In addition we present the results of two case studies from southwestern coastal areas where shrimp farming originated and central coastal areas where shrimp farming, especially M. rosenbergii, began in recent years. Lessons learned from the review and case studies are considered in the context of recommendations to encompass a socially equitable and ecologically sound coastal aquaculture.

Current and future treatment options for community-associated MRSA infection.

PubMed

Khan, A; Wilson, B; Gould, I M

2018-04-01

Community-associated MRSA (CA-MRSA) represents a global epidemic which beautifully encapsulates the fascinating ability of bacterial organisms to adapt quickly on an evolutionary basis to the extreme selective pressure of antibiotic exposure. In stark contrast to Healthcare-associated MRSA (HA-MRSA), it has become apparent that CA-MRSA is less straight forward of a challenge in terms of controlling its transmission, and has forced clinicians to adjust empiric management of clinical syndromes such as skin and soft tissue infection (SSTI) as well as pneumonia. Areas covered: This review details the history and epidemiology of CA-MRSA, while covering both current and future treatment options that are and may be available to clinicians. The authors reviewed both historic and more recent literature on this ever-evolving topic. Expert opinion: While development of new anti-MRSA agents should be encouraged, the importance of antimicrobial stewardship in the battle to stay ahead of the curve with regards to the ongoing control of the MRSA epidemic should be emphasised.

Fascinating Magnetic Energy Storage Nanomaterials: A Brief Review.

PubMed

Sreenivasulu, Kummari V; Srikanth, Vadali V S S

2017-07-10

In this brief review, the importance of nanotechnology in developing novel magnetic energy storage materials is discussed. The discussion covers recent patents on permanent magnetic materials and especially covers processing of permanent magnets (rare-earth and rare-earth free magnets), importance of rare-earth permanent magnets and necessity of rare-earth free permanent magnets. Magnetic energy storage materials are those magnetic materials which exhibit very high energy product (BH)max (where B is the magnetic induction in Gauss (G) whereas H is the applied magnetic field in Oersted (Oe)). (BH)max is the direct measure of the ability of a magnetic material to store energy. In this context, processing of magnetic energy storage composite materials constituted by soft and hard magnetic materials played a predominant role in achieving high (BH)max values due to the exchange coupling phenomenon between the soft and hard magnetic phases within the composite. Magnetic energy storage composites are normally composed of rare-earth magnetic materials as well as rare-earth free magnetic materials. Nanotechnology's influence on the enhancement of energy product due to the exchange coupling phenomenon is of great prominence and therefore discussed in this review. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Doped graphene supercapacitors.

PubMed

Kumar, Nanjundan Ashok; Baek, Jong-Beom

2015-12-11

Heteroatom-doped graphitic frameworks have received great attention in energy research, since doping endows graphitic structures with a wide spectrum of properties, especially critical for electrochemical supercapacitors, which tend to complement or compete with the current lithium-ion battery technology/devices. This article reviews the latest developments in the chemical modification/doping strategies of graphene and highlights the versatility of such heteroatom-doped graphitic structures. Their role as supercapacitor electrodes is discussed in detail. This review is specifically focused on the concept of material synthesis, techniques for electrode fabrication and metrics of performance, predominantly covering the last four years. Challenges and insights into the future research and perspectives on the development of novel electrode architectures for electrochemical supercapacitors based on doped graphene are also discussed.

Doped graphene supercapacitors

NASA Astrophysics Data System (ADS)

Ashok Kumar, Nanjundan; Baek, Jong-Beom

2015-12-01

Heteroatom-doped graphitic frameworks have received great attention in energy research, since doping endows graphitic structures with a wide spectrum of properties, especially critical for electrochemical supercapacitors, which tend to complement or compete with the current lithium-ion battery technology/devices. This article reviews the latest developments in the chemical modification/doping strategies of graphene and highlights the versatility of such heteroatom-doped graphitic structures. Their role as supercapacitor electrodes is discussed in detail. This review is specifically focused on the concept of material synthesis, techniques for electrode fabrication and metrics of performance, predominantly covering the last four years. Challenges and insights into the future research and perspectives on the development of novel electrode architectures for electrochemical supercapacitors based on doped graphene are also discussed.

Heterocyclic N-Oxides – An Emerging Class of Therapeutic Agents

PubMed Central

Mfuh, Adelphe M.; Larionov, Oleg V.

2016-01-01

Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and procognitive activities. The N-oxide motif has been successfully employed in a number of recent drug development projects. This review surveys the emergence of this scaffold in the mainstream medicinal chemistry with a focus on the discovery of the heterocyclic N-oxide drugs, N-oxide-specific mechanisms of action, drug-receptor interactions and synthetic avenues to these compounds. As the first review on this subject that covers the developments since 1950s to date, it is expected that it will inspire wider implementation of the heterocyclic N-oxide motif in the rational design of new medicinal agents. PMID:26087764

Economic Evaluation of Computerized Structural Analysis

NASA Technical Reports Server (NTRS)

Fortin, P. E.

1985-01-01

This completed effort involved a technical and economic study of the capabilities of computer programs in the area of structural analysis. The applicability of the programs to NASA projects and to other users was studied. The applications in other industries was explored including both research and development and applied areas. The costs of several alternative analysis programs were compared. A literature search covered applicable technical literature including journals, trade publications and books. In addition to the literature search, several commercial companies that have developed computerized structural analysis programs were contacted and their technical brochures reviewed. These programs include SDRC I-DEAS, MSC/NASTRAN, SCADA, SUPERSAP, NISA/DISPLAY, STAAD-III, MICAS, GTSTRUDL, and STARS. These programs were briefly reviewed as applicable to NASA projects.

State variable theories based on Hart's formulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korhonen, M.A.; Hannula, S.P.; Li, C.Y.

In this paper a review of the development of a state variable theory for nonelastic deformation is given. The physical and phenomenological basis of the theory and the constitutive equations describing macroplastic, microplastic, anelastic and grain boundary sliding enhanced deformation are presented. The experimental and analytical evaluation of different parameters in the constitutive equations are described in detail followed by a review of the extensive experimental work on different materials. The technological aspects of the state variable approach are highlighted by examples of the simulative and predictive capabilities of the theory. Finally, a discussion of general capabilities, limitations and futuremore » developments of the theory and particularly the possible extensions to cover an even wider range of deformation or deformation-related phenomena is presented.« less

Physical forms of MIPs.

PubMed

Biffis, Andrea; Dvorakova, Gita; Falcimaigne-Cordin, Aude

2012-01-01

The current state of the art in the development of methodologies for the preparation of MIPs in predetermined physical forms is critically reviewed, with particular attention being paid to the forms most widely employed in practical applications, such as spherical beads in the micro- to nanometer range, microgels, monoliths, membranes. Although applications of the various MIP physical forms are mentioned, the focus of the paper is mainly on the description of the various preparative methods. The aim is to provide the reader with an overview of the latest achievements in the field, as well as with a mean for critically evaluating the various proposed methodologies towards an envisaged application. The review covers the literature up to early 2010, with special emphasis on the developments of the last 10 years.

Quantitative 1H NMR: Development and Potential of an Analytical Method – an Update

PubMed Central

Pauli, Guido F.; Gödecke, Tanja; Jaki, Birgit U.; Lankin, David C.

2012-01-01

Covering the literature from mid-2004 until the end of 2011, this review continues a previous literature overview on quantitative 1H NMR (qHNMR) methodology and its applications in the analysis of natural products (NPs). Among the foremost advantages of qHNMR is its accurate function with external calibration, the lack of any requirement for identical reference materials, a high precision and accuracy when properly validated, and an ability to quantitate multiple analytes simultaneously. As a result of the inclusion of over 170 new references, this updated review summarizes a wealth of detailed experiential evidence and newly developed methodology that supports qHNMR as a valuable and unbiased analytical tool for natural product and other areas of research. PMID:22482996

Deformation and failure information from composite materials via acoustic emission

NASA Technical Reports Server (NTRS)

Hamstad, M. A.

1978-01-01

The paper reviews some principles of applying acoustic emission (AE) to the study of fiber-composite materials and structures. This review covers the basics of using AE to monitor the deformation and fracture processes that occur when fiber-composite materials are stressed. Also, new results in some areas of current research interest are presented. The following areas are emphasized: study of couplants for AE testing of composites, evaluation of a special immersion-type AE transducer, and wave propagation complications and the development of techniques for locating AE sources in Kevlar 49/epoxy composite pre

Long life assurance study for manned spacecraft long life hardware. Volume 1: Summary of long life assurance guidelines

NASA Technical Reports Server (NTRS)

1972-01-01

A long life assurance program for the development of design, process, test, and application guidelines for achieving reliable spacecraft hardware was conducted. The study approach consisted of a review of technical data performed concurrently with a survey of the aerospace industry. The data reviewed included design and operating characteristics, failure histories and solutions, and similar documents. The topics covered by the guidelines are reported. It is concluded that long life hardware is achieved through meticulous attention to many details and no simple set of rules can suffice.

Benign paroxysmal vertigo of childhood: A review of the literature

PubMed Central

Batson, Glenna

2004-01-01

Childrens’ complaints of headache and dizziness merit careful evaluation to differentially diagnose a vestibular disorder. Children can manifest with a syndrome mimicking certain classic signs and symptoms of adult vestibular disorders, such as benign paroxysmal positional vertigo, usually associated with aging. Benign paroxysmal vertigo of childhood in which migraine is a key manifestation along with sudden onset of dizziness, is a rare peripheral vestibular disorder in children that is commonly overlooked or misdiagnosed. This review covers the historical development of the diagnosis, evaluation and treatment approaches of benign paroxysmal vertigo of childhood. PMID:19654978

Therapy for Clostridium difficile infection - any news beyond Metronidazole and Vancomycin?

PubMed

Manthey, C F; Eckmann, L; Fuhrmann, V

2017-11-01

Infections with Clostridium difficile (CDI) represent a major burden for the health care system. Treatment is generally by antibiotic therapy with metronidazole and vancomycin, but efficacy remains suboptimal. Areas covered: This review discusses established and emerging treatment options for CDI, and current therapeutic guidelines, taking into account disease severity and risk of relapse. Expert commentary: New therapeutic approaches, including antibodies and new classes of antibiotics, and new measures for preventing infection with vaccines are under development in phase II/III clinical trials. We performed a systematic literature review using the search terms 'Clostridium difficile' and 'treatment'.

Stripping voltammetry in environmental and food analysis.

PubMed

Brainina, K Z; Malakhova, N A; Stojko, N Y

2000-10-01

The review covers over 230 papers published mostly in the last 5 years. The goal of the review is to attract the attention of researchers and users to stripping voltammetry in particular, its application in environmental monitoring and analysis of foodstuffs. The sensors employed are impregnated graphite, carbon paste, thick film carbon/graphite and thin film metallic electrodes modified in-situ or beforehand. Hanging mercury drop electrodes and mercury coated glassy carbon electrodes are also mentioned. Strip and long-lived sensors for portable instruments and flow through systems are discussed as devices for future development and application of stripping voltammetry.

Stimuli-Responsive Polymers for Actuation.

PubMed

Zhang, Qiang Matthew; Serpe, Michael J

2017-06-02

A variety of stimuli-responsive polymers have been developed and used as actuators and/or artificial muscles, with the movement being driven by an external stimulus, such as electrical potential. This Review highlights actuators constructed from liquid-crystal elastomers, dielectric elastomers, ionic polymers, and conducting polymers. The Review covers recent examples of a variety of actuators generated from these materials and their utility. The mechanism of actuation will be detailed for most examples in order to stimulate possible future research, and lead to new applications and advanced applications. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Genus Caulophyllum: An Overview of Chemistry and Bioactivity

PubMed Central

Xia, Yong-Gang; Li, Guo-Yu; Liang, Jun; Yang, Bing-You; Lü, Shao-Wa; Kuang, Hai-Xue

2014-01-01

Recently, some promising advances have been achieved in understanding the chemistry, pharmacology, and action mechanisms of constituents from genus Caulophyllum. Despite this, there is to date no systematic review of those of genus Caulophyllum. This review covers naturally occurring alkaloids and saponins and those resulting from synthetic novel taspine derivatives. The paper further discussed several aspects of this genus, including pharmacological properties, mechanisms of action, pharmacokinetics, and cell membrane chromatography for activity screening. The aim of this paper is to provide a point of reference for pharmaceutical researchers to develop new drugs from constituents of Caulophyllum plants. PMID:24876877

Genus caulophyllum: an overview of chemistry and bioactivity.

PubMed

Xia, Yong-Gang; Li, Guo-Yu; Liang, Jun; Yang, Bing-You; Lü, Shao-Wa; Kuang, Hai-Xue

2014-01-01

Recently, some promising advances have been achieved in understanding the chemistry, pharmacology, and action mechanisms of constituents from genus Caulophyllum. Despite this, there is to date no systematic review of those of genus Caulophyllum. This review covers naturally occurring alkaloids and saponins and those resulting from synthetic novel taspine derivatives. The paper further discussed several aspects of this genus, including pharmacological properties, mechanisms of action, pharmacokinetics, and cell membrane chromatography for activity screening. The aim of this paper is to provide a point of reference for pharmaceutical researchers to develop new drugs from constituents of Caulophyllum plants.

Land use/cover classification in the Brazilian Amazon using satellite images.

PubMed

Lu, Dengsheng; Batistella, Mateus; Li, Guiying; Moran, Emilio; Hetrick, Scott; Freitas, Corina da Costa; Dutra, Luciano Vieira; Sant'anna, Sidnei João Siqueira

2012-09-01

Land use/cover classification is one of the most important applications in remote sensing. However, mapping accurate land use/cover spatial distribution is a challenge, particularly in moist tropical regions, due to the complex biophysical environment and limitations of remote sensing data per se. This paper reviews experiments related to land use/cover classification in the Brazilian Amazon for a decade. Through comprehensive analysis of the classification results, it is concluded that spatial information inherent in remote sensing data plays an essential role in improving land use/cover classification. Incorporation of suitable textural images into multispectral bands and use of segmentation-based method are valuable ways to improve land use/cover classification, especially for high spatial resolution images. Data fusion of multi-resolution images within optical sensor data is vital for visual interpretation, but may not improve classification performance. In contrast, integration of optical and radar data did improve classification performance when the proper data fusion method was used. Of the classification algorithms available, the maximum likelihood classifier is still an important method for providing reasonably good accuracy, but nonparametric algorithms, such as classification tree analysis, has the potential to provide better results. However, they often require more time to achieve parametric optimization. Proper use of hierarchical-based methods is fundamental for developing accurate land use/cover classification, mainly from historical remotely sensed data.

Land use/cover classification in the Brazilian Amazon using satellite images

PubMed Central

Lu, Dengsheng; Batistella, Mateus; Li, Guiying; Moran, Emilio; Hetrick, Scott; Freitas, Corina da Costa; Dutra, Luciano Vieira; Sant’Anna, Sidnei João Siqueira

2013-01-01

Land use/cover classification is one of the most important applications in remote sensing. However, mapping accurate land use/cover spatial distribution is a challenge, particularly in moist tropical regions, due to the complex biophysical environment and limitations of remote sensing data per se. This paper reviews experiments related to land use/cover classification in the Brazilian Amazon for a decade. Through comprehensive analysis of the classification results, it is concluded that spatial information inherent in remote sensing data plays an essential role in improving land use/cover classification. Incorporation of suitable textural images into multispectral bands and use of segmentation-based method are valuable ways to improve land use/cover classification, especially for high spatial resolution images. Data fusion of multi-resolution images within optical sensor data is vital for visual interpretation, but may not improve classification performance. In contrast, integration of optical and radar data did improve classification performance when the proper data fusion method was used. Of the classification algorithms available, the maximum likelihood classifier is still an important method for providing reasonably good accuracy, but nonparametric algorithms, such as classification tree analysis, has the potential to provide better results. However, they often require more time to achieve parametric optimization. Proper use of hierarchical-based methods is fundamental for developing accurate land use/cover classification, mainly from historical remotely sensed data. PMID:24353353

77 FR 77017 - Certain Orange Juice From Brazil: Notice of Court Decision Not in Harmony With Final Results of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

..., International Trade Administration, Department of Commerce. SUMMARY: On October 24, 2012, the United States... juice (OJ) from Brazil covering the period of review (POR) of March 1, 2008, through February 28, 2009... administrative review of OJ from Brazil covering the POR of March 1, 2008, through February 28, 2009. See Certain...

Semi-annual conference review January-June 2000

Treesearch

John K. Borchardt; Marguerite S. Sykes; Mahendra R. Doshi

2000-01-01

Conferences covered in this semiannual review include the TAPPI Recycling Symposium and the 9th PTS/CTP Deinking Symposium. The intent of this feature is to present a synopsis of the significant research results and industry ideas related to paper recycling reported at these conferences. Due to space constraints, we are not able to cover all of the presented papers in...

Cholinesterase inhibitors: a patent review (2007 - 2011).

PubMed

de los Ríos, Cristóbal

2012-08-01

Cholinesterase inhibitors participate in the maintenance of the levels of the neurotransmitter acetylcholine by inhibiting the enzymes implicated in its degradation, namely, butyrylcholinesterase and acetylcholinesterase. This pharmacological action has an important role in several diseases, including neurodegenerative diseases such as Alzheimer's. This article reviews recent advances in the development of cholinesterase enzyme inhibitors, covering the development of new chemical entities, new pharmaceutical formulations with known inhibitors or treatments in combination with other drug families. The development of cholinesterase inhibitors has to face several issues, including the fact that the principal indication for these drugs, Alzheimer's disease, is not currently believed to derivate from a cholinergic deficiency, although most of the drugs clinically used for these disease are cholinesterase inhibitors. Moreover, the adverse effects found when administering cholinesterase inhibitors limit their use in other diseases, such as gastrointestinal diseases, glaucoma, or analgesia.

Secondary School Advanced Mathematics, Chapter 4, Equations, Inequalities, and Radicals, Chapter 5, Circles and Spheres. Teacher's Commentary.

ERIC Educational Resources Information Center

Stanford Univ., CA. School Mathematics Study Group.

This manual was designed for use with the third of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered in…

Secondary School Advanced Mathematics, Chapter 1, Organizing Geometric Knowledge, Chapter 2, Concepts and Skills in Algebra. Teacher's Commentary.

ERIC Educational Resources Information Center

Stanford Univ., CA. School Mathematics Study Group.

This manual was designed for use with the first of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered in…

Naval Research Reviews, Volume 32, Number 4

DTIC Science & Technology

1980-01-01

iron while (e.g., carbon, chlorine, phosphorous, sulfur, zinc other areas are still covered by an oxide . An XPS and boron). An example of the chemical...picture. Metallic bearing components, for ex- major impact on tribology. The first is the develop- ample, usually have complex oxide films on their...the composition or thickncs. IThe optical image is m,.chanisms responsible for ion beam degradation of rotated slightly withrespecttoelectronimages

A Data Miner for the Information Power Grid

NASA Technical Reports Server (NTRS)

Hinke, Thomas H.; Parks, John W. (Technical Monitor)

2002-01-01

Grid Miner (GM) is one of the early data mining applications developed by NASA to help users obtain information from the Information Power Grid (IPG). Topics cover include: benefits of data mining, potential use of grids in data mining activities, an overview of the GM application, and a brief review of GM architecture and implementation issues. The current status of the GM system is also discussed.

PEP solar array definition study

NASA Technical Reports Server (NTRS)

1979-01-01

The power extension package (PEP) is a solar array system that will be used on the space transportation system to augment the power of the Orbiter vehicle and to extend the time the vehicle may stay in orbit. The baseline configuration of the PEP is reviewed. The programmatic aspects of the design covering the development plan, the manufacturing facility plan and the estimated costs and risks are presented.

Establishing Teacher Competencies in Early Care and Education: A Review of Current Models and Options for California. Building California's Preschool for All Workforce. A Series of Policy Briefs

ERIC Educational Resources Information Center

Bellm, Dan

2005-01-01

This policy brief provides guidelines grouped into five areas: personal and professional behavior; classroom environment; health, safety and nutrition; working with families and communities; and administration and management. The document discusses the topics that teacher competencies generally cover, options for how they might be developed and…

Approaches to Machine Learning.

DTIC Science & Technology

1984-02-16

The field of machine learning strives to develop methods and techniques to automatic the acquisition of new information, new skills, and new ways of organizing existing information. In this article, we review the major approaches to machine learning in symbolic domains, covering the tasks of learning concepts from examples, learning search methods, conceptual clustering, and language acquisition. We illustrate each of the basic approaches with paradigmatic examples. (Author)

Faculty Assessment Project for Colleges of Osteopathic Medicine. Final Report, Covers Period of Performance During September 26, 1977-October 25, 1978. Volumes 1, 2, and 3.

ERIC Educational Resources Information Center

American Association of Colleges of Osteopathic Medicine, Washington, DC.

The three volume report includes (1) an executive summary; (2) a comprehensive report reviewing the literature on current faculty development needs in schools of osteopathic medicine; and (3) a volume of resource materials. The study gauges the formal organizational and programmatic factors that influence the success of faculty development…

Quantitative image processing in fluid mechanics

NASA Technical Reports Server (NTRS)

Hesselink, Lambertus; Helman, James; Ning, Paul

1992-01-01

The current status of digital image processing in fluid flow research is reviewed. In particular, attention is given to a comprehensive approach to the extraction of quantitative data from multivariate databases and examples of recent developments. The discussion covers numerical simulations and experiments, data processing, generation and dissemination of knowledge, traditional image processing, hybrid processing, fluid flow vector field topology, and isosurface analysis using Marching Cubes.

EDITORIAL: Metrologia

NASA Astrophysics Data System (ADS)

Blackburn, D. A.

1991-01-01

Visually, this issue of Metrologia differs markedly from those of recent years. The cover is changed and the layout of articles is not quite what it was before. Older readers, however, may notice that the colour of our new cover is that used for the original eleven volumes published in the period 1965-1975. The choice is deliberate: this combination of innovation with a respect for older forms characterizes the way Metrologia will operate under its new publisher the Bureau International des Poids et Mesures. In discussion of the new Metrologia, one decision was firm: our underlying editorial policy remains fixed. Metrologia will remain a primary vehicle through which the metrological community communicates progress in fundamental scientific measurements, reports original experiments and techniques, reviews work in specialist fields and disseminates the decisions of the Comité International des Poids et Mesures. This year, we plan six issues. Four will be regular research issues, one, appearing mid-Summer, will record the proceedings of the meeting held in Davos, Switzerland 20-22 September 1990 on "New Developments and Advances in Optical Radiometry III" and another, towards the end of the year, will review progress in Nanometrology. If successful, the pattern will be repeated, the intention being that the research issues continue Metrologia's historical line of interest, the conference issues expose the journal to new authors and the review issues realize a long-standing, but largely inactive, objective of editorial policy, the provision of retrospective evaluations of important topics and the assessment of likely developments in selected aspects of metrology.

Atomic force microscopy on chromosomes, chromatin and DNA: a review.

PubMed

Kalle, Wouter; Strappe, Padraig

2012-12-01

The purpose of this review is to discuss the achievements and progress that has been made in the use of atomic force microscopy in DNA related research in the last 25 years. For this review DNA related research is split up in chromosomal-, chromatin- and DNA focused research to achieve a logical flow from large- to smaller structures. The focus of this review is not only on the AFM as imaging tool but also on the AFM as measuring tool using force spectroscopy, as therein lays its greatest advantage and future. The amazing technological and experimental progress that has been made during the last 25 years is too extensive to fully cover in this review but some key developments and experiments have been described to give an overview of the evolution of AFM use from 'imaging tool' to 'measurement tool' on chromosomes, chromatin and DNA. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

1999 NASA High-Speed Research Program Aerodynamic Performance Workshop. Volume 1; Configuration Aerodynamics

NASA Technical Reports Server (NTRS)

Hahne, David E. (Editor)

1999-01-01

NASA's High-Speed Research Program sponsored the 1999 Aerodynamic Performance Technical Review on February 8-12, 1999 in Anaheim, California. The review was designed to bring together NASA and industry High-Speed Civil Transport (HSCT) Aerodynamic Performance technology development participants in the areas of Configuration Aerodynamics (transonic and supersonic cruise drag prediction and minimization), High Lift, and Flight Controls. The review objectives were to: (1) report the progress and status of HSCT aerodynamic performance technology development; (2) disseminate this technology within the appropriate technical communities; and (3) promote synergy among the scientists and engineers working on HSCT aerodynamics. In particular, single and midpoint optimized HSCT configurations, HSCT high-lift system performance predictions, and HSCT simulation results were presented, along with executive summaries for all the Aerodynamic Performance technology areas. The HSR Aerodynamic Performance Technical Review was held simultaneously with the annual review of the following airframe technology areas: Materials and Structures, Environmental Impact, Flight Deck, and Technology Integration. Thus, a fourth objective of the Review was to promote synergy between the Aerodynamic Performance technology area and the other technology areas of the HSR Program. This Volume 1/Part 1 publication covers configuration aerodynamics.

1999 NASA High-Speed Research Program Aerodynamic Performance Workshop. Volume 1; Configuration Aerodynamics

NASA Technical Reports Server (NTRS)

Hahne, David E. (Editor)

1999-01-01

NASA's High-Speed Research Program sponsored the 1999 Aerodynamic Performance Technical Review on February 8-12, 1999 in Anaheim, California. The review was designed to bring together NASA and industry High-Speed Civil Transport (HSCT) Aerodynamic Performance technology development participants in the areas of Configuration Aerodynamics (transonic and supersonic cruise drag prediction and minimization), High Lift, and Flight Controls. The review objectives were to (1) report the progress and status of HSCT aerodynamic performance technology development; (2) disseminate this technology within the appropriate technical communities; and (3) promote synergy among the scientists and engineers working on HSCT aerodynamics. In particular, single and midpoint optimized HSCT configurations, HSCT high-lift system performance predictions, and HSCT simulation results were presented, along with executive summaries for all the Aerodynamic Performance technology areas. The HSR Aerodynamic Performance Technical Review was held simultaneously with the annual review of the following airframe technology areas: Materials and Structures, Environmental Impact, Flight Deck, and Technology Integration. Thus, a fourth objective of the Review was to promote synergy between the Aerodynamic Performance technology area and the other technology areas of the HSR Program. This Volume 1/Part 2 publication covers the design optimization and testing sessions.

The Astrophysics Source Code Library: An Update

NASA Astrophysics Data System (ADS)

Allen, Alice; Nemiroff, R. J.; Shamir, L.; Teuben, P. J.

2012-01-01

The Astrophysics Source Code Library (ASCL), founded in 1999, takes an active approach to sharing astrophysical source code. ASCL's editor seeks out both new and old peer-reviewed papers that describe methods or experiments that involve the development or use of source code, and adds entries for the found codes to the library. This approach ensures that source codes are added without requiring authors to actively submit them, resulting in a comprehensive listing that covers a significant number of the astrophysics source codes used in peer-reviewed studies. The ASCL moved to a new location in 2010, and has over 300 codes in it and continues to grow. In 2011, the ASCL (http://asterisk.apod.com/viewforum.php?f=35) has on average added 19 new codes per month; we encourage scientists to submit their codes for inclusion. An advisory committee has been established to provide input and guide the development and expansion of its new site, and a marketing plan has been developed and is being executed. All ASCL source codes have been used to generate results published in or submitted to a refereed journal and are freely available either via a download site or from an identified source. This presentation covers the history of the ASCL and examines the current state and benefits of the ASCL, the means of and requirements for including codes, and outlines its future plans.

Themed section: Advances in nutritional pharmacology. Editorial.

PubMed

Wainwright, C L; McGrath, J C

2009-09-01

A themed section in this issue of Br J Pharmacol, on 'Advances in Nutritional Pharmacology', provides a valuable and timely update on progress in this area. The value of dietary components to improvement in health and, particularly, to prevention of cardiovascular disease and cancer, is frequently reported in the media and therefore often captures the attention of the wider public. Understanding the pharmacological mechanisms by which nutritional elements confer their health benefits enables us to keep the public informed, but also aids in the identification of new targets for drug development. In recent years there has been significant progress in this field. Four rapidly developing areas are reviewed. Vosper (2009) covers the identification of a receptor for niacin and the subsequent development of selective agonists as lipid lowering agents. Wu-Wong (2009) describes the development of new Vitamin D analogues for the treatment of cardiovascular disease. de Roos et al. (2009) provide detailed insight into how omega-3 fatty acids, also known as longchain n-3 polyunsaturated fatty acids (PUFAs) protect against cardiovascular disease. Zhou et al. (2009) cover the mechanisms underlying the beneficial effects of resveretrol in protection against cancer. These reviews are complimented by three key original articles focusing on endogenous mechanisms of weight control involving endocannabinoids (Izzo et al., 2009), a circulating protein, the soluble leptin receptor (Zhang & Scarpace, 2009) and a treatment, zinc plus cyclo-(His-Pro) (CHP), known to increase insulin metabolism (Song et al., 2009).

Review of Sexuality Studies in Africa: Setting a New Post-2015 Research Agenda.

PubMed

Akinyemi, Joshua O; De Wet, Nicole; Odimegwu, Clifford O

2016-03-01

At the nexus between reproductive health, population and development is the subject of sexuality which has generated extensive discourse in the past two decades. In this paper, we review Africa sexuality studies published between 1994 and 2015 with the aim of synthesizing the available evidence and suggesting a new research agenda for post-2015. Review findings showed that previous studies covered the five components of sexuality - practices, partners, pleasure/pressure/pain, procreation and power to different extents. Risky sexual behaviour was prevalent from adolescence till older ages. Literature on pleasure, pain, procreation and power reflect the complex diversity driven by traditional norms, gender roles and attitudes across the continent. Knowledge gaps were highlighted and new agenda suggested for sexuality research.

Mindfulness in mood and anxiety disorders: a review of the literature.

PubMed

Rodrigues, Michele F; Nardi, Antonio E; Levitan, Michelle

2017-01-01

The objective of this study was to conduct a review of the literature covering the use of different mindfulness-based therapy approaches in treatment of mood and anxiety disorders, including mindfulness skills and mindfulness linked to emotional regulation and fear of negative appraisal. A review was conducted of literature identified by searching the scientific databases PubMed and PsycINFO with the following keywords: mindfulness, mood disorders, and anxiety disorders. The search covered the past 10 years. The search returned 532 articles, 24 were selected, their full texts were read, and 16 were included in this review. Six articles about mindfulness-based stress reduction, four about mindfulness-based cognitive therapy, and three about fear of negative appraisal and emotional regulation were reviewed. All of the articles covered mindfulness in relation to mood and anxiety disorders. The literature in this field suggests that mindfulness is an effective strategy for the treatment of mood and anxiety disorders and is effective in therapy protocols with different structures including virtual modalities. Use of mindfulness in scientific models continues to expand.

Biodiversity as a multidimensional construct: a review, framework and case study of herbivory's impact on plant biodiversity

PubMed Central

Naeem, S.; Prager, Case; Weeks, Brian; Varga, Alex; Flynn, Dan F. B.; Griffin, Kevin; Muscarella, Robert; Palmer, Matthew; Wood, Stephen; Schuster, William

2016-01-01

Biodiversity is inherently multidimensional, encompassing taxonomic, functional, phylogenetic, genetic, landscape and many other elements of variability of life on the Earth. However, this fundamental principle of multidimensionality is rarely applied in research aimed at understanding biodiversity's value to ecosystem functions and the services they provide. This oversight means that our current understanding of the ecological and environmental consequences of biodiversity loss is limited primarily to what unidimensional studies have revealed. To address this issue, we review the literature, develop a conceptual framework for multidimensional biodiversity research based on this review and provide a case study to explore the framework. Our case study specifically examines how herbivory by whitetail deer (Odocoileus virginianus) alters the multidimensional influence of biodiversity on understory plant cover at Black Rock Forest, New York. Using three biodiversity dimensions (taxonomic, functional and phylogenetic diversity) to explore our framework, we found that herbivory alters biodiversity's multidimensional influence on plant cover; an effect not observable through a unidimensional approach. Although our review, framework and case study illustrate the advantages of multidimensional over unidimensional approaches, they also illustrate the statistical and empirical challenges such work entails. Meeting these challenges, however, where data and resources permit, will be important if we are to better understand and manage the consequences we face as biodiversity continues to decline in the foreseeable future. PMID:27928041

Biodiversity as a multidimensional construct: a review, framework and case study of herbivory's impact on plant biodiversity.

PubMed

Naeem, S; Prager, Case; Weeks, Brian; Varga, Alex; Flynn, Dan F B; Griffin, Kevin; Muscarella, Robert; Palmer, Matthew; Wood, Stephen; Schuster, William

2016-12-14

Biodiversity is inherently multidimensional, encompassing taxonomic, functional, phylogenetic, genetic, landscape and many other elements of variability of life on the Earth. However, this fundamental principle of multidimensionality is rarely applied in research aimed at understanding biodiversity's value to ecosystem functions and the services they provide. This oversight means that our current understanding of the ecological and environmental consequences of biodiversity loss is limited primarily to what unidimensional studies have revealed. To address this issue, we review the literature, develop a conceptual framework for multidimensional biodiversity research based on this review and provide a case study to explore the framework. Our case study specifically examines how herbivory by whitetail deer (Odocoileus virginianus) alters the multidimensional influence of biodiversity on understory plant cover at Black Rock Forest, New York. Using three biodiversity dimensions (taxonomic, functional and phylogenetic diversity) to explore our framework, we found that herbivory alters biodiversity's multidimensional influence on plant cover; an effect not observable through a unidimensional approach. Although our review, framework and case study illustrate the advantages of multidimensional over unidimensional approaches, they also illustrate the statistical and empirical challenges such work entails. Meeting these challenges, however, where data and resources permit, will be important if we are to better understand and manage the consequences we face as biodiversity continues to decline in the foreseeable future. © 2016 The Authors.

Rapid systematic review shows that using a high-flow nasal cannula is inferior to nasal continuous positive airway pressure as first-line support in preterm neonates.

PubMed

Conte, Francesca; Orfeo, Luigi; Gizzi, Camilla; Massenzi, Luca; Fasola, Salvatore

2018-05-11

We reviewed using a high-flow nasal cannula (HFNC) as first-line support for preterm neonates with, or at risk of, respiratory distress. This rapid systematic review covered biomedical databases up to June 2017. We included randomised controlled trials (RCTs) published in English. The reference lists of the studies and relevant reviews we included were also screened. We performed the study selection, data extraction, study quality assessment, meta-analysis and quality of evidence assessment following the Grading of Recommendations Assessment, Development and Evaluation system. Pooled results from six RCTs covering 1227 neonates showed moderate-quality evidence that HFNC was associated with a higher rate of failure than nasal continuous positive airway pressure (NCPAP) in preterm neonates of at least 28 weeks of gestation, with a risk ratio of 1.57. Low-quality evidence showed no significant differences between HFNC and NCPAP in the need for intubation and bronchopulmonary dysplasia rate. HFNC yielded a lower rate of nasal injury (risk ratio 0.50). When HFNC failed, intubation was avoided in some neonates by switching them to NCPAP. HFNC had higher failure rates than NCPAP when used as first-line support. Subsequently switching to NCPAP sometimes avoided intubation. Data on the most immature neonates were lacking. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

10 CFR 1304.115 - Systems of records covered by exemptions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Systems of records covered by exemptions. 1304.115 Section 1304.115 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.115 Systems of records covered by exemptions. The Board currently has no exempt systems of records. ...

10 CFR 1304.115 - Systems of records covered by exemptions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Systems of records covered by exemptions. 1304.115 Section 1304.115 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.115 Systems of records covered by exemptions. The Board currently has no exempt systems of records. ...

10 CFR 1304.115 - Systems of records covered by exemptions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Systems of records covered by exemptions. 1304.115 Section 1304.115 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.115 Systems of records covered by exemptions. The Board currently has no exempt systems of records. ...

10 CFR 1304.115 - Systems of records covered by exemptions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Systems of records covered by exemptions. 1304.115 Section 1304.115 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.115 Systems of records covered by exemptions. The Board currently has no exempt systems of records. ...

10 CFR 1304.115 - Systems of records covered by exemptions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Systems of records covered by exemptions. 1304.115 Section 1304.115 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.115 Systems of records covered by exemptions. The Board currently has no exempt systems of records. ...

Key results of the mini-dome Fresnel lens concentrator array development program under recently completed NASA and SDIO SBIR projects

NASA Technical Reports Server (NTRS)

Oneill, Mark J.; Piszczor, Michael F.; Fraas, Lewis M.

1991-01-01

Since 1986, ENTECH and the NASA Lewis Research Center have been developing a new photovoltaic concentrator system for space power applications. The unique refractive system uses small, dome shaped Fresnel lenses to focus sunlight onto high efficiency photovoltaic concentrator cells which use prismatic cell covers to further increase their performance. Highlights of the five-year development include near Air Mass Zero (AM0) Lear Jet flight testing of mini-dome lenses (90 pct. net optical efficiency achieved); tests verifying sun-pointing error tolerance with negligible power loss; simulator testing of prism-covered GaAs concentrator cells (24 pct. AM0 efficiency); testing of prism-covered Boeing GaAs/GaSb tandem cells (31 pct. AM0 efficiency); and fabrication and outdoor testing of a 36-lens/cell element panel. These test results have confirmed previous analytical predictions which indicate substantial performance improvements for this technology over current array systems. Based on program results to date, it appears than an array power density of 300 watts/sq m and a specific power of 100 watts/kg can be achieved in the near term. All components of the array appear to be readily manufacturable from space-durable materials at reasonable cost. A concise review is presented of the key results leading to the current array, and further development plans for the future are briefly discussed.

Operational Applications of Satellite Snowcover Observations

NASA Technical Reports Server (NTRS)

Rango, A. (Editor); Peterson, R. (Editor)

1980-01-01

The history of remote sensing of snow cover is reviewed and the following topics are covered: various techniques for interpreting LANDSAT and NOAA satellite data; the status of future systems for continuing snow hydrology applications; the use of snow cover observations in streamflow forecasts by Applications Systems Verification and Transfer participants and selected foreign investigators; and the benefits of using satellite snow cover data in runoff prediction.

Transmission Pathways and Mediators as the Basis for Clinical Pharmacology of Pain

PubMed Central

Kirkpatrick, Daniel R.; McEntire, Dan M.; Smith, Tyler A.; Dueck, Nicholas P.; Kerfeld, Mitchell J.; Hambsch, Zakary J.; Nelson, Taylor J.; Reisbig, Mark D.; Agrawal, Devendra K.

2016-01-01

Introduction Mediators in pain transmission are the targets of a multitude of different analgesic pharmaceuticals. This review explores the most significant mediators of pain transmission as well as the pharmaceuticals that act on them. Areas Covered The review explores many of the key mediators of pain transmission. In doing so, this review uncovers important areas for further research. It also highlights agents with potential for producing novel analgesics, probes important interactions between pain transmission pathways that could contribute to synergistic analgesia, and emphasizes transmission factors that participate in transforming acute injury into chronic pain. Expert Commentary This review examines current pain research, particularly in the context of identifying novel analgesics, highlighting interactions between analgesic transmission pathways, and discussing factors that may contribute to the development of chronic pain after an acute injury. PMID:27322358

How to Introduce the Imperfection Sensitivity Concept into Design 2

NASA Technical Reports Server (NTRS)

Elishakoff, Isaac

1998-01-01

The previous review on stochastic buckling of structures was written by Amazigo in 1976. The present review summarizes some of the developments which took place in recent two decades. A brief overview is given of the effect on uncertainty in the initial geometric imperfections, elastic moduli, applied forces, and thickness variation. For the benefit of the thinking reader, the review has a critical nature. Present essay should be viewed as a direct continuation of our previous paper (1983) with the same title. In order not to repeat what was covered there, it appears instructive to read it although not necessarily prior to dwelling on this article. Accordingly the title is appended with the serial number. It is not promised that the third review will follow since the university science, both fortunately and unfortunately, stands on three things: relevance, interest, and grants.

Organizational impact of nurse supply and workload on nurses continuing professional development opportunities: an integrative review.

PubMed

Coventry, Tracey H; Maslin-Prothero, Sian E; Smith, Gilly

2015-12-01

To identify the best evidence on the impact of healthcare organizations' supply of nurses and nursing workload on the continuing professional development opportunities of Registered Nurses in the acute care hospital. To maintain registration and professional competence nurses are expected to participate in continuing professional development. One challenge of recruitment and retention is the Registered Nurse's ability to participate in continuing professional development opportunities. The integrative review method was used to present Registered Nurses perspectives on this area of professional concern. The review was conducted for the period of 2001-February 2015. Keywords were: nurs*, continuing professional development, continuing education, professional development, supply, shortage, staffing, workload, nurse: patient ratio, barrier and deterrent. The integrative review used a structured approach for literature search and data evaluation, analysis and presentation. Eleven international studies met the inclusion criteria. Nurses are reluctant or prevented from leaving clinical settings to attend continuing professional development due to lack of relief cover, obtaining paid or unpaid study leave, use of personal time to undertake mandatory training and organizational culture and leadership issues constraining the implementation of learning to benefit patients. Culture, leadership and workload issues impact nurses' ability to attend continuing professional development. The consequences affect competence to practice, the provision of safe, quality patient care, maintenance of professional registration, job satisfaction, recruitment and retention. Organizational leadership plays an important role in supporting attendance at continuing professional development as an investment for the future. © 2015 John Wiley & Sons Ltd.

Delivery of cosmetic covers to persons with transtibial and transfemoral amputations in an outpatient prosthetic practice.

PubMed

Highsmith, M Jason; Kahle, Jason T; Knight, Molly; Olk-Szost, Ayla; Boyd, Melinda; Miro, Rebecca M

2016-06-01

Limb loss negatively impacts body image to the extent that functional activity and societal participation are affected. Scientific literature is lacking on the subject of cosmetic covering for prostheses and the rate of cosmetic cover utilization by cover type, gender, amputation level, and type of healthcare reimbursement. To describe the delivery of cosmetic covers in lower limb prostheses in a sample of people with lower extremity amputation. Cross-sectional design Patient records from an outpatient practice were reviewed for people who received a transtibial or transfemoral prosthesis within a selected 2-year period. A total of 294 records were reviewed. Regardless of the amputation level, females were significantly (p ≤ 0.05) more likely to receive a cover. Type of insurance did not affect whether or not a cover was used, but Medicare reimbursed more pull-up skin covers. There were differences regarding cosmetic cover delivery based on gender, and Medicare reimbursed for more pull-up skin covers at the transtibial level than other reimbursors did. This analysis was conducted in a warm, tropical geographic region of the United States. Results may differ in other parts of the world based on many factors including climate and local views of body image and disability. Cosmetic covering rates are clinically relevant because they provide insight into which gender is utilizing more cosmetic covers. Furthermore, it can be determined which type of covers are being utilized with greater frequency and which insurance type is providing more coverage for them. © The International Society for Prosthetics and Orthotics 2015.

Research related to variable sweep aircraft development

NASA Technical Reports Server (NTRS)

Polhamus, E. C.; Toll, T. A.

1981-01-01

Development in high speed, variable sweep aircraft research is reviewed. The 1946 Langley wind tunnel studies related to variable oblique and variable sweep wings and results from the X-5 and the XF1OF variable sweep aircraft are discussed. A joint program with the British, evaluation of the British "Swallow", development of the outboard pivot wing/aft tail configuration concept by Langley, and the applied research program that followed and which provided the technology for the current, variable sweep military aircraft is outlined. The relative state of variable sweep as a design option is also covered.

[Traditional and modern approaches to culture of preimplantation mammalian embryos in vitro].

PubMed

Brusentsev, E Iu; Igonina, T N; Amstislavskiĭ, S Ia

2014-01-01

This review covers the basic principles and methods of in vitro culture of preimplantation mammalian embryos. The features of in vitro development of embryos of various species of animals with allowance for the composition of nutrient media are described, with special attention paid to those species that have traditionally been consideredas laboratory (i.e., mice, rats, and hamsters). The effects of suboptimal culturing conditions of preimplantation embryos on the formation of the phenotype of individuals developed from these embryos are discussed. New approaches to optimize the conditions of the development of preimplantation mammalian embryos in vitro are analyzed.

Operations research for resource planning and -use in radiotherapy: a literature review.

PubMed

Vieira, Bruno; Hans, Erwin W; van Vliet-Vroegindeweij, Corine; van de Kamer, Jeroen; van Harten, Wim

2016-11-25

The delivery of radiotherapy (RT) involves the use of rather expensive resources and multi-disciplinary staff. As the number of cancer patients receiving RT increases, timely delivery becomes increasingly difficult due to the complexities related to, among others, variable patient inflow, complex patient routing, and the joint planning of multiple resources. Operations research (OR) methods have been successfully applied to solve many logistics problems through the development of advanced analytical models for improved decision making. This paper presents the state of the art in the application of OR methods for logistics optimization in RT, at various managerial levels. A literature search was performed in six databases covering several disciplines, from the medical to the technical field. Papers included in the review were published in peer-reviewed journals from 2000 to 2015. Data extraction includes the subject of research, the OR methods used in the study, the extent of implementation according to a six-stage model and the (potential) impact of the results in practice. From the 33 papers included in the review, 18 addressed problems related to patient scheduling (of which 12 focus on scheduling patients on linear accelerators), 8 focus on strategic decision making, 5 on resource capacity planning, and 2 on patient prioritization. Although calculating promising results, none of the papers reported a full implementation of the model with at least a thorough pre-post performance evaluation, indicating that, apart from possible reporting bias, implementation rates of OR models in RT are probably low. The literature on OR applications in RT covers a wide range of approaches from strategic capacity management to operational scheduling levels, and shows that considerable benefits in terms of both waiting times and resource utilization are likely to be achieved. Various fields can be further developed, for instance optimizing the coordination between the available capacity of different imaging devices or developing scheduling models that consider the RT chain of operations as a whole rather than the treatment machines alone.

Public involvement at the design stage of primary health research: a narrative review of case examples.

PubMed

Boote, Jonathan; Baird, Wendy; Beecroft, Claire

2010-04-01

To review published examples of public involvement in research design, to synthesise the contributions made by members of the public, as well as the identified barriers, tensions and facilitating strategies. Systematic literature search and narrative review. Seven papers were identified covering the following topics: breast-feeding, antiretroviral and nutrition interventions; paediatric resuscitation; exercise and cognitive behavioural therapy; hormone replacement therapy and breast cancer; stroke; and parents' experiences of having a pre-term baby. Six papers reported public involvement in the development of a clinical trial, while one reported public involvement in the development of a mixed methods study. Group meetings were the most common method of public involvement. Contributions that members of the public made to research design were: review of consent procedures and patient information sheets; outcome suggestions; review of acceptability of data collection procedures; and recommendations on the timing of potential participants into the study and the timing of follow-up. Numerous barriers, tensions and facilitating strategies were identified. The issues raised here should assist researchers in developing research proposals with members of the public. Substantive and methodological directions for further research on the impact of public involvement in research design are set out. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

Attenuation correction in emission tomography using the emission data—A review

PubMed Central

Li, Yusheng

2016-01-01

The problem of attenuation correction (AC) for quantitative positron emission tomography (PET) had been considered solved to a large extent after the commercial availability of devices combining PET with computed tomography (CT) in 2001; single photon emission computed tomography (SPECT) has seen a similar development. However, stimulated in particular by technical advances toward clinical systems combining PET and magnetic resonance imaging (MRI), research interest in alternative approaches for PET AC has grown substantially in the last years. In this comprehensive literature review, the authors first present theoretical results with relevance to simultaneous reconstruction of attenuation and activity. The authors then look back at the early history of this research area especially in PET; since this history is closely interwoven with that of similar approaches in SPECT, these will also be covered. We then review algorithmic advances in PET, including analytic and iterative algorithms. The analytic approaches are either based on the Helgason–Ludwig data consistency conditions of the Radon transform, or generalizations of John’s partial differential equation; with respect to iterative methods, we discuss maximum likelihood reconstruction of attenuation and activity (MLAA), the maximum likelihood attenuation correction factors (MLACF) algorithm, and their offspring. The description of methods is followed by a structured account of applications for simultaneous reconstruction techniques: this discussion covers organ-specific applications, applications specific to PET/MRI, applications using supplemental transmission information, and motion-aware applications. After briefly summarizing SPECT applications, we consider recent developments using emission data other than unscattered photons. In summary, developments using time-of-flight (TOF) PET emission data for AC have shown promising advances and open a wide range of applications. These techniques may both remedy deficiencies of purely MRI-based AC approaches in PET/MRI and improve standalone PET imaging. PMID:26843243

Attenuation correction in emission tomography using the emission data—A review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berker, Yannick, E-mail: berker@mail.med.upenn.edu; Li, Yusheng

2016-02-15

The problem of attenuation correction (AC) for quantitative positron emission tomography (PET) had been considered solved to a large extent after the commercial availability of devices combining PET with computed tomography (CT) in 2001; single photon emission computed tomography (SPECT) has seen a similar development. However, stimulated in particular by technical advances toward clinical systems combining PET and magnetic resonance imaging (MRI), research interest in alternative approaches for PET AC has grown substantially in the last years. In this comprehensive literature review, the authors first present theoretical results with relevance to simultaneous reconstruction of attenuation and activity. The authors thenmore » look back at the early history of this research area especially in PET; since this history is closely interwoven with that of similar approaches in SPECT, these will also be covered. We then review algorithmic advances in PET, including analytic and iterative algorithms. The analytic approaches are either based on the Helgason–Ludwig data consistency conditions of the Radon transform, or generalizations of John’s partial differential equation; with respect to iterative methods, we discuss maximum likelihood reconstruction of attenuation and activity (MLAA), the maximum likelihood attenuation correction factors (MLACF) algorithm, and their offspring. The description of methods is followed by a structured account of applications for simultaneous reconstruction techniques: this discussion covers organ-specific applications, applications specific to PET/MRI, applications using supplemental transmission information, and motion-aware applications. After briefly summarizing SPECT applications, we consider recent developments using emission data other than unscattered photons. In summary, developments using time-of-flight (TOF) PET emission data for AC have shown promising advances and open a wide range of applications. These techniques may both remedy deficiencies of purely MRI-based AC approaches in PET/MRI and improve standalone PET imaging.« less

An Automated Algorithm for Producing Land Cover Information from Landsat Surface Reflectance Data Acquired Between 1984 and Present

NASA Astrophysics Data System (ADS)

Rover, J.; Goldhaber, M. B.; Holen, C.; Dittmeier, R.; Wika, S.; Steinwand, D.; Dahal, D.; Tolk, B.; Quenzer, R.; Nelson, K.; Wylie, B. K.; Coan, M.

2015-12-01

Multi-year land cover mapping from remotely sensed data poses challenges. Producing land cover products at spatial and temporal scales required for assessing longer-term trends in land cover change are typically a resource-limited process. A recently developed approach utilizes open source software libraries to automatically generate datasets, decision tree classifications, and data products while requiring minimal user interaction. Users are only required to supply coordinates for an area of interest, land cover from an existing source such as National Land Cover Database and percent slope from a digital terrain model for the same area of interest, two target acquisition year-day windows, and the years of interest between 1984 and present. The algorithm queries the Landsat archive for Landsat data intersecting the area and dates of interest. Cloud-free pixels meeting the user's criteria are mosaicked to create composite images for training the classifiers and applying the classifiers. Stratification of training data is determined by the user and redefined during an iterative process of reviewing classifiers and resulting predictions. The algorithm outputs include yearly land cover raster format data, graphics, and supporting databases for further analysis. Additional analytical tools are also incorporated into the automated land cover system and enable statistical analysis after data are generated. Applications tested include the impact of land cover change and water permanence. For example, land cover conversions in areas where shrubland and grassland were replaced by shale oil pads during hydrofracking of the Bakken Formation were quantified. Analytical analysis of spatial and temporal changes in surface water included identifying wetlands in the Prairie Pothole Region of North Dakota with potential connectivity to ground water, indicating subsurface permeability and geochemistry.

Conversion Reaction-Based Oxide Nanomaterials for Lithium Ion Battery Anodes.

PubMed

Yu, Seung-Ho; Lee, Soo Hong; Lee, Dong Jun; Sung, Yung-Eun; Hyeon, Taeghwan

2016-04-27

Developing high-energy-density electrodes for lithium ion batteries (LIBs) is of primary importance to meet the challenges in electronics and automobile industries in the near future. Conversion reaction-based transition metal oxides are attractive candidates for LIB anodes because of their high theoretical capacities. This review summarizes recent advances on the development of nanostructured transition metal oxides for use in lithium ion battery anodes based on conversion reactions. The oxide materials covered in this review include oxides of iron, manganese, cobalt, copper, nickel, molybdenum, zinc, ruthenium, chromium, and tungsten, and mixed metal oxides. Various kinds of nanostructured materials including nanowires, nanosheets, hollow structures, porous structures, and oxide/carbon nanocomposites are discussed in terms of their LIB anode applications. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Engineering metallic nanostructures for plasmonics and nanophotonics

PubMed Central

Lindquist, Nathan C; Nagpal, Prashant; McPeak, Kevin M; Norris, David J; Oh, Sang-Hyun

2012-01-01

Metallic nanostructures now play an important role in many applications. In particular, for the emerging fields of plasmonics and nanophotonics, the ability to engineer metals on nanometric scales allows the development of new devices and the study of exciting physics. This review focuses on top-down nanofabrication techniques for engineering metallic nanostructures, along with computational and experimental characterization techniques. A variety of current and emerging applications are also covered. PMID:22790420

Cosmology, Clusters and Calorimeters

NASA Technical Reports Server (NTRS)

Figueroa-Feliciano, Enectali

2005-01-01

I will review the current state of Cosmology with Clusters and discuss the application of microcalorimeter arrays to this field. With the launch of Astro-E2 this summer and a slew of new missions being developed, microcalorimeters are the next big thing in x-ray astronomy. I will cover the basics and not-so-basic concepts of microcalorimeter designs and look at the future to see where this technology will go.

Flight Awareness Collaboration Tool Development

NASA Technical Reports Server (NTRS)

Mogford, Richard

2016-01-01

This is a PowerPoint presentation covering airline operations center (AOC) research. It reviews a dispatcher decision support tool called the Flight Awareness Collaboration Tool (FACT). FACT gathers information about winter weather onto one screen and includes predictive abilities. FACT should prove to be useful for airline dispatchers and airport personnel when they manage winter storms and their effect on air traffic. This material is very similar to other previously approved presentations.

Engineering metallic nanostructures for plasmonics and nanophotonics

NASA Astrophysics Data System (ADS)

Lindquist, Nathan C.; Nagpal, Prashant; McPeak, Kevin M.; Norris, David J.; Oh, Sang-Hyun

2012-03-01

Metallic nanostructures now play an important role in many applications. In particular, for the emerging fields of plasmonics and nanophotonics, the ability to engineer metals on nanometric scales allows the development of new devices and the study of exciting physics. This review focuses on top-down nanofabrication techniques for engineering metallic nanostructures, along with computational and experimental characterization techniques. A variety of current and emerging applications are also covered.

Advances in the synthesis of α-quaternary α-ethynyl α-amino acids.

PubMed

Boibessot, Thibaut; Bénimélis, David; Meffre, Patrick; Benfodda, Zohra

2016-09-01

α-Quaternary α-ethynyl α-amino acids are an important class of non-proteinogenic amino acids that play an important role in the development of peptides and peptidomimetics as therapeutic agents and in the inhibition of enzyme activities. This review provides an overview of the literature concerning synthesis and applications of α-quaternary α-ethynyl α-amino acids covering the period from 1977 to 2015.

Revealing facts behind spray dried solid dispersion technology used for solubility enhancement

PubMed Central

Patel, Bhavesh B.; Patel, Jayvadan K.; Chakraborty, Subhashis; Shukla, Dali

2013-01-01

Poor solubility and bioavailability of an existing or newly synthesized drug always pose challenge in the development of efficient pharmaceutical formulation. Numerous technologies can be used to improve the solubility and among them amorphous solid dispersion based spray drying technology can be successfully useful for development of product from lab scale to commercial scale with a wide range of powder characteristics. Current review deals with the importance of spray drying technology in drug delivery, basically for solubility and bioavailability enhancement. Role of additives, selection of polymer, effect of process and formulation parameters, scale up optimization, and IVIVC have been covered to gain the interest of readers about the technology. Design of experiment (DoE) to optimize the spray drying process has been covered in the review. A lot more research work is required to evaluate spray drying as a technology for screening the right polymer for solid dispersion, especially to overcome the issue related to drug re-crystallization and to achieve a stable product both in vitro and in vivo. Based on the recent FDA recommendation, the need of the hour is also to adopt Quality by Design approach in the manufacturing process to carefully optimize the spray drying technology for its smooth transfer from lab scale to commercial scale. PMID:27134535

Revealing facts behind spray dried solid dispersion technology used for solubility enhancement.

PubMed

Patel, Bhavesh B; Patel, Jayvadan K; Chakraborty, Subhashis; Shukla, Dali

2015-09-01

Poor solubility and bioavailability of an existing or newly synthesized drug always pose challenge in the development of efficient pharmaceutical formulation. Numerous technologies can be used to improve the solubility and among them amorphous solid dispersion based spray drying technology can be successfully useful for development of product from lab scale to commercial scale with a wide range of powder characteristics. Current review deals with the importance of spray drying technology in drug delivery, basically for solubility and bioavailability enhancement. Role of additives, selection of polymer, effect of process and formulation parameters, scale up optimization, and IVIVC have been covered to gain the interest of readers about the technology. Design of experiment (DoE) to optimize the spray drying process has been covered in the review. A lot more research work is required to evaluate spray drying as a technology for screening the right polymer for solid dispersion, especially to overcome the issue related to drug re-crystallization and to achieve a stable product both in vitro and in vivo. Based on the recent FDA recommendation, the need of the hour is also to adopt Quality by Design approach in the manufacturing process to carefully optimize the spray drying technology for its smooth transfer from lab scale to commercial scale.

Gaps in the evidence for prevention and treatment of maternal anaemia: a review of systematic reviews.

PubMed

Parker, Jacqui A; Barroso, Filipa; Stanworth, Simon J; Spiby, Helen; Hopewell, Sally; Doree, Carolyn J; Renfrew, Mary J; Allard, Shubha

2012-06-24

Anaemia, in particular due to iron deficiency, is common in pregnancy with associated negative outcomes for mother and infant. However, there is evidence of significant variation in management. The objectives of this review of systematic reviews were to analyse and summarise the evidence base, identify gaps in the evidence and develop a research agenda for this important component of maternity care. Multiple databases were searched, including MEDLINE, EMBASE and The Cochrane Library. All systematic reviews relating to interventions to prevent and treat anaemia in the antenatal and postnatal period were eligible. Two reviewers independently assessed data inclusion, extraction and quality of methodology. 27 reviews were included, all reporting on the prevention and treatment of anaemia in the antenatal (n = 24) and postnatal periods (n = 3). Using AMSTAR as the assessment tool for methodological quality, only 12 of the 27 were rated as high quality reviews. The greatest number of reviews covered antenatal nutritional supplementation for the prevention of anaemia (n = 19). Iron supplementation was the most extensively researched, but with ongoing uncertainty about optimal dose and regimen. Few identified reviews addressed anaemia management post-partum or correlations between laboratory and clinical outcomes, and no reviews reported on clinical symptoms of anaemia. The review highlights evidence gaps including the management of anaemia in the postnatal period, screening for anaemia, and optimal interventions for treatment. Research priorities include developing standardised approaches to reporting of laboratory outcomes, and information on clinical outcomes relevant to the experiences of pregnant women.

Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges

PubMed Central

Habel, Joachim; Hansen, Michael; Kynde, Søren; Larsen, Nanna; Midtgaard, Søren Roi; Jensen, Grethe Vestergaard; Bomholt, Julie; Ogbonna, Anayo; Almdal, Kristoffer; Schulz, Alexander; Hélix-Nielsen, Claus

2015-01-01

In recent years, aquaporin biomimetic membranes (ABMs) for water separation have gained considerable interest. Although the first ABMs are commercially available, there are still many challenges associated with further ABM development. Here, we discuss the interplay of the main components of ABMs: aquaporin proteins (AQPs), block copolymers for AQP reconstitution, and polymer-based supporting structures. First, we briefly cover challenges and review recent developments in understanding the interplay between AQP and block copolymers. Second, we review some experimental characterization methods for investigating AQP incorporation including freeze-fracture transmission electron microscopy, fluorescence correlation spectroscopy, stopped-flow light scattering, and small-angle X-ray scattering. Third, we focus on recent efforts in embedding reconstituted AQPs in membrane designs that are based on conventional thin film interfacial polymerization techniques. Finally, we describe some new developments in interfacial polymerization using polyhedral oligomeric silsesquioxane cages for increasing the physical and chemical durability of thin film composite membranes. PMID:26264033

Qualitative Development of the PROMIS® Pediatric Stress Response Item Banks

PubMed Central

Gardner, William; Pajer, Kathleen; Riley, Anne W.; Forrest, Christopher B.

2013-01-01

Objective To describe the qualitative development of the Patient-Reported Outcome Measurement Information System (PROMIS®) Pediatric Stress Response item banks. Methods Stress response concepts were specified through a literature review and interviews with content experts, children, and parents. A library comprising 2,677 items derived from 71 instruments was developed. Items were classified into conceptual categories; new items were written and redundant items were removed. Items were then revised based on cognitive interviews (n = 39 children), readability analyses, and translatability reviews. Results 2 pediatric Stress Response sub-domains were identified: somatic experiences (43 items) and psychological experiences (64 items). Final item pools cover the full range of children’s stress experiences. Items are comprehensible among children aged ≥8 years and ready for translation. Conclusions Child- and parent-report versions of the item banks assess children’s somatic and psychological states when demands tax their adaptive capabilities. PMID:23124904

Besifloxacin: A Critical Review of Its Characteristics, Properties, and Analytical Methods.

PubMed

Tótoli, Eliane Gandolpho; Salgado, Hérida Regina Nunes

2018-03-04

Bacterial conjunctivitis has high impact on the health of the population, since it represents more than a third of ocular pathologies reported by health services worldwide. There is a high incidence of bacterial resistance to the antimicrobials most commonly used for the treatment of conjunctivitis. In this context, besifloxacin stands out, since it is a fluoroquinolone developed exclusively for topical ophthalmic use, presenting a low risk of developing resistance due to its reduced systemic exposure. Bausch & Lomb markets it as ophthalmic suspension, under the trade name Besivance™. Literature review on besifloxacin is presented, covering its pharmaceutical and clinical characteristics, and the analytical methods used to measure the drug in pharmaceutical products and biological samples. High performance liquid chromatography is the most used method for this purpose. A discussion on Green Chemistry is also presented, focusing the importance of the development of green analytical methods for the analysis of drugs.

Development of the field of structural physiology

PubMed Central

FUJIYOSHI, Yoshinori

2015-01-01

Electron crystallography is especially useful for studying the structure and function of membrane proteins — key molecules with important functions in neural and other cells. Electron crystallography is now an established technique for analyzing the structures of membrane proteins in lipid bilayers that closely simulate their natural biological environment. Utilizing cryo-electron microscopes with helium-cooled specimen stages that were developed through a personal motivation to understand the functions of neural systems from a structural point of view, the structures of membrane proteins can be analyzed at a higher than 3 Å resolution. This review covers four objectives. First, I introduce the new research field of structural physiology. Second, I recount some of the struggles involved in developing cryo-electron microscopes. Third, I review the structural and functional analyses of membrane proteins mainly by electron crystallography using cryo-electron microscopes. Finally, I discuss multifunctional channels named “adhennels” based on structures analyzed using electron and X-ray crystallography. PMID:26560835

CLINICAL FOLLOW-UP FOR DUCHENNE MUSCULAR DYSTROPHY NEWBORN SCREENING: A PROPOSAL

PubMed Central

KWON, JENNIFER M.; ABDEL-HAMID, HODA Z.; AL-ZAIDY, SAMIAH A.; MENDELL, JERRY R.; KENNEDY, ANNIE; KINNETT, KATHI; CWIK, VALERIE A.; STREET, NATALIE; BOLEN, JULIE; DAY, JOHN W.; CONNOLLY, ANNE M.

2017-01-01

New developments in the rapid diagnosis and treatment of boys with Duchenne muscular dystrophy (DMD) have led to growing enthusiasm for instituting DMD newborn screening (NBS) in the United States. Our group has been interested in developing clinical guidance to be implemented consistently in specialty care clinics charged with the care of presymptomatically identified newborns referred after DMD-NBS. We reviewed the existing literature covering patient-centered clinical follow-up after NBS, educational material from public health and advocacy sites, and federal recommendations on effective NBS follow-up. We discussed the review as a group and added our own experience to develop materials suitable for initial parent and primary care provider education. These materials and a series of templates for subspecialist encounters could be used to provide consistent care across centers and serve as the basis for ongoing quality improvement. PMID:27170260

Clinical Follow-Up for Duchenne Muscular Dystrophy Newborn Screening: A Proposal.

PubMed

Kwon, Jennifer M; Abdel-Hamid, Hoda Z; Al-Zaidy, Samiah A; Mendell, Jerry R; Kennedy, Annie; Kinnett, Kathi; Cwik, Valerie A; Street, Natalie; Bolen, Julie; Day, John W; Connolly, Anne M

2016-08-01

New developments in the rapid diagnosis and treatment of boys with Duchenne muscular dystrophy (DMD) have led to growing enthusiasm for instituting DMD newborn screening (NBS) in the United States. Our group has been interested in developing clinical guidance to be implemented consistently in specialty care clinics charged with the care of presymptomatically identified newborns referred after DMD-NBS. We reviewed the existing literature covering patient-centered clinical follow-up after NBS, educational material from public health and advocacy sites, and federal recommendations on effective NBS follow-up. We discussed the review as a group and added our own experience to develop materials suitable for initial parent and primary care provider education. These materials and a series of templates for subspecialist encounters could be used to provide consistent care across centers and serve as the basis for ongoing quality improvement. Muscle Nerve 54: 186-191, 2016. © 2016 Wiley Periodicals, Inc.

Cork Composites: A Review

PubMed Central

Gil, Luís

2009-01-01

Cork is a material which has been used for mankind for the last 5,000 years and it is a strategic material used for multiple applications, from wine bottles to aeronautics. Many of current cork materials are composites, in particular cork materials for floor and wall coverings and several other building and industrial applications. Recent developments in cork research have shifted from the classical cork-wine relationship to quality and environmental issues, exploitation of cork industry residues and new cork based materials. In recent years a number of new cork based composite materials were developed.

Accelerator-based BNCT.

PubMed

Kreiner, A J; Baldo, M; Bergueiro, J R; Cartelli, D; Castell, W; Thatar Vento, V; Gomez Asoia, J; Mercuri, D; Padulo, J; Suarez Sandin, J C; Erhardt, J; Kesque, J M; Valda, A A; Debray, M E; Somacal, H R; Igarzabal, M; Minsky, D M; Herrera, M S; Capoulat, M E; Gonzalez, S J; del Grosso, M F; Gagetti, L; Suarez Anzorena, M; Gun, M; Carranza, O

2014-06-01

The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented. In particular, the present status and recent progress of the Argentine project will be reviewed. The topics will cover: intense ion sources, accelerator tubes, transport of intense beams, beam diagnostics, the (9)Be(d,n) reaction as a possible neutron source, Beam Shaping Assemblies (BSA), a treatment room, and treatment planning in realistic cases. © 2013 Elsevier Ltd. All rights reserved.

Self-Expandable Metallic Stent Placement for the Palliation of Esophageal Cancer

PubMed Central

2017-01-01

Esophageal stents have been used to palliate patients with dysphagia caused by esophageal cancer. Early rigid plastic prostheses have been associated with a high risk of complications. However, with the development of self-expanding stents, it has developed into a widely accepted method for treating malignant esophageal strictures and esophagorespiratory fistulas (ERFs). The present review covers various aspects of self-expanding metallic stent placement for palliating esophageal cancer, including its types, placement procedures, indications, contraindications, complications, and some of innovations that will become available in the future. PMID:28581260

Nuclear Propulsion Technical Interchange Meeting, volume 1

NASA Technical Reports Server (NTRS)

1993-01-01

The Nuclear Propulsion Technical Interchange Meeting (NP-TIM-92) was sponsored and hosted by the Nuclear Propulsion Office at the NASA Lewis Research Center. The purpose of the meeting was to review the work performed in fiscal year 1992 in the areas of nuclear thermal and nuclear electric propulsion technology development. These proceedings are a compilation of the presentations given at the meeting (many of the papers are presented in outline or viewgraph form). Volume 1 covers the introductory presentations and the system concepts and technology developments related to nuclear thermal propulsion.

Identification, Prevention and Treatment of Iron Deficiency during the First 1000 Days

PubMed Central

Burke, Rachel M.; Leon, Juan S.; Suchdev, Parminder S.

2014-01-01

Iron deficiency is a global problem across the life course, but infants and their mothers are especially vulnerable to both the development and the consequences of iron deficiency. Maternal iron deficiency during pregnancy can predispose offspring to the development of iron deficiency during infancy, with potentially lifelong sequelae. This review explores iron status throughout these “first 1000 days” from pregnancy through two years of age, covering the role of iron and the epidemiology of iron deficiency, as well as its consequences, identification, interventions and remaining research gaps. PMID:25310252

Development of Technologies to Utilize Laser Plasma Radiations Sources for Radiation Effects Sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, J F

2007-01-31

This final report will cover work performed over the period of November 11, 2005 to September 30, 2006 on the contract to develop technologies using laser sources for radiation effects sciences. The report will discuss four topic areas; the laser source experiments on the Gekko Laser at Osaka, Japan, planning for the Charge State Freeze Out experiments to be performed in calendar year 2007, a review of previous xenon gasbags on the LANL Trident laser to provide planning support to the May-June 2007 HELEN experiments.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seapan, M.; Crynes, B.L.; Dale, S.

The objectives of this study were to analyze alternate crudes kinetic hydrotreatment data in the literature, develop a mathematical model for interpretation of these data, develop an experimental procedure and apparatus to collect accurate kinetic data, and finally, to combine the model and experimental data to develop a general model which, with a few experimental parameters, could be used in design of future hydrotreatment processes. These objectives were to cover a four year program (1980 to 1984) and were subjective to sufficient funding. Only partial funding has been available thus far to cover activities for two years. A hydrotreatment datamore » base is developed which contains over 2000 citations, stored in a microcomputer. About 50% of these are reviewed, classified and can be identified by feedstock, catalyst, reactor type and other process characteristics. Tests of published hydrodesulfurization data indicate the problems with simple n-th order, global kinetic models, and point to the value of developing intrinsic reaction kinetic models to describe the reaction processes. A Langmuir-Hinshelwood kinetic model coupled with a plug flow reactor design equation has been developed and used for published data evaluation. An experimental system and procedure have been designed and constructed, which can be used for kinetic studies. 30 references, 4 tables.« less

Some Recent Developments on Financial Incentives for Smoking Cessation Among Pregnant and Newly Postpartum Women.

PubMed

Higgins, Stephen T; Solomon, Laura J

2016-03-01

Smoking during pregnancy is a leading preventable cause of poor pregnancy outcomes and immediate and longer-term adverse health outcomes among exposed offspring. Developing more effective smoking-cessation interventions for pregnant women has been a public-health priority for more than thirty years. We review developments over the past three years (2012-15) on the use of financial incentives to promote smoking cessation among pregnant women. We searched the literature for reports on primary and secondary analyses and reviews of controlled trials on this topic published in peer-reviewed journals using the search engine PubMed, reviewed bibliographies of published articles, and consulted expert colleagues. The search revealed several important developments, with the following three being especially noteworthy. First, the review identified four new randomized controlled trials, three of which further supported the efficacy of this treatment approach. One of the three trials supporting efficacy also included the first econometric analysis of this treatment approach showing financial incentives with pregnant smokers to be highly cost-effective. Second, two Cochrane reviews were published during this 3-year period covering the more recent and earlier efficacy trials. Meta-analyses in both reviews supported the efficacy of the approach. Lastly, the first effectiveness trial was reported demonstrating that financial incentives increased abstinence rates above control levels when implemented by obstetrical clinic staff in a large urban hospital working with community tobacco interventionists. Overall, t here is a growing and compelling body of evidence supporting the efficacy and cost-effectiveness of financial incentives for smoking cessation among pregnant women.

A land use and land cover classification system for use with remote sensor data

USGS Publications Warehouse

Anderson, James R.; Hardy, Ernest E.; Roach, John T.; Witmer, Richard E.

1976-01-01

The framework of a national land use and land cover classification system is presented for use with remote sensor data. The classification system has been developed to meet the needs of Federal and State agencies for an up-to-date overview of land use and land cover throughout the country on a basis that is uniform in categorization at the more generalized first and second levels and that will be receptive to data from satellite and aircraft remote sensors. The proposed system uses the features of existing widely used classification systems that are amenable to data derived from remote sensing sources. It is intentionally left open-ended so that Federal, regional, State, and local agencies can have flexibility in developing more detailed land use classifications at the third and fourth levels in order to meet their particular needs and at the same time remain compatible with each other and the national system. Revision of the land use classification system as presented in U.S. Geological Survey Circular 671 was undertaken in order to incorporate the results of extensive testing and review of the categorization and definitions.

Atezolizumab for the treatment of non-small cell lung cancer.

PubMed

Santini, Fernando C; Rudin, Charles M

2017-09-01

The immune system can restrain or promote cancer development and growth. Antibodies targeting immune checkpoints have revolutionized cancer treatment. Among the best responses have been in non-small cell lung cancer (NSCLC) which is largely caused by chronic exposure to carcinogens; associated with high neoantigen creation and sensitization to immune recognition. Atezolizumab was the first approved antibody that targets the PD-1 ligand (PD-L1). Areas covered: This drug profile article covers the basics of the cancer-immunity cycle and reviews some aspects of innate and adaptive immunology. We discuss the discovery of PD-L1 and PD-L2 while highlight the potential differences in targeting PD-L1 versus PD-1. In addition, we briefly summarized the available pre-clinical and clinical data of atezolizumab use in NSCLC. A special section covers the challenges of PD-L1 immunohistochemistry assay. Expert commentary: PD-1:PD-L1 blockade has taken the lead in the immunotherapeutics field and represents the backbone of developing combination immunotherapies. Atezolizumab represents a step forward in the treatment of advanced NSCLC, nonetheless PD1:PD-L1 blockade in early-stage lung cancer is still a matter of debate.

Systems biology of seeds: deciphering the molecular mechanisms of seed storage, dormancy and onset of germination.

PubMed

Sreenivasulu, Nese

2017-05-01

Seeds are heterogeneous storage reserves with wide array of storage compounds that include various soluble carbohydrates, starch polymer, storage proteins and lipids. These stored reserves comprise 70% of the world's caloric intake in the form of food and animal feed produced through sustainable agriculture, which contributes to food and nutritional security. Seed systems biology remains an enigmatic subject in understanding seed storage processes, maturation and pre-germinative metabolism. The reviews and research articles covered in this special issue of Plant Cell Reports highlight recent advances made in the area of seed biology that cover various systems biology applications such as gene regulatory networks, metabolomics, epigenetics and the role of micro-RNA in seed development.

The use of laser in hysteroscopic surgery.

PubMed

Nappi, Luigi; Sorrentino, Felice; Angioni, Stefano; Pontis, Alessandro; Greco, Pantaleo

2016-12-01

The term laser, an acronym for light amplification by stimulated emission of radiation, covers a wide range of devices. Lasers are commonly described by the emitted wavelength that covers the entire light spectrum from infrared to ultraviolet and the active lasing medium. Currently, over forty different types of lasers have found application in medicine. Moreover, advances made by gynecologists in the field of operative hysteroscopy have developed a very great interest in the use of surgical lasers. Technical improvements in hysteroscopes and lasers have led several gynecologists to evaluate their use in the surgical treatment of intrauterine pathologies. This narrative review concerns the most common used lasers in hysteroscopic surgery with particular attention to the latest promising results of the laser technology.

Attempting to detect and record brushland in the northeastern United States using MSS data - Schoharie County, N.Y., as a case study

NASA Technical Reports Server (NTRS)

Baumann, Paul R.

1990-01-01

Before county and local governments will utilize satellite data extensively for landcover inventories, digital image processing techniques must be developed to identify transitional land-use conditions and create large-scale, readable land-cover maps. This study examines a satellite-based land-cover inventory done for Schoharie County, New York and reviews the problems encountered in identifying and mapping brushland - a significant transitional land use - within the county and region. Brushland throughout the Northeast represents a barometer for measuring the shift away from agricultural land use to second-home property. Detecting and locating brushland on a regular basis can greatly assist county and local government officials in planning and managing a county's future.

Homologation Reaction of Ketones with Diazo Compounds.

PubMed

Candeias, Nuno R; Paterna, Roberta; Gois, Pedro M P

2016-03-09

This review covers the addition of diazo compounds to ketones to afford homologated ketones, either in the presence or in the absence of promoters or catalysts. Reactions with diazoalkanes, aryldiazomethanes, trimethylsilyldiazomethane, α-diazo esters, and disubstituted diazo compounds are covered, commenting on the complex regiochemistry of the reaction and the nature of the catalysts and promoters. The recent reports on the enantioselective version of ketone homologation reactions are gathered in one section, followed by reports on the use of cyclic ketones ring expansion in total synthesis. Although the first reports of this reaction appeared in the literature almost one century ago, the recent achievements, in particular, for the asymmetric version, forecast the development of new breakthroughs in the synthetically valuable field of diazo chemistry.

National climate assessment technical report on the impacts of climate and land use and land cover change

USGS Publications Warehouse

Loveland, Thomas; Mahmood, Rezaul; Patel-Weynand, Toral; Karstensen, Krista; Beckendorf, Kari; Bliss, Norman; Carleton, Andrew

2012-01-01

This technical report responds to the recognition by the U.S. Global Change Research Program (USGCRP) and the National Climate Assessment (NCA) of the importance of understanding how land use and land cover (LULC) affects weather and climate variability and change and how that variability and change affects LULC. Current published, peer-reviewed, scientific literature and supporting data from both existing and original sources forms the basis for this report's assessment of the current state of knowledge regarding land change and climate interactions. The synthesis presented herein documents how current and future land change may alter environment processes and in turn, how those conditions may affect both land cover and land use by specifically investigating, * The primary contemporary trends in land use and land cover, * The land-use and land-cover sectors and regions which are most affected by weather and climate variability,* How land-use practices are adapting to climate change, * How land-use and land-cover patterns and conditions are affecting weather and climate, and * The key elements of an ongoing Land Resources assessment. These findings present information that can be used to better assess land change and climate interactions in order to better assess land management and adaptation strategies for future environmental change and to assist in the development of a framework for an ongoing national assessment.

Developing blended online and classroom strategies to deliver an occupational health nursing overview course in a multi-state region in the United States.

PubMed

de Castro, A B; Shapleigh, Erin; Bruck, Annie; Salazar, Mary K

2015-03-01

This article describes how hybrid online and classroom learning approaches were used to design and offer an occupational health nursing review course throughout a multi-state region of the northwest United States. In response to demand from practicing occupational health nurses for board certification preparation, a series of asynchronous and synchronous continuing education modules was created covering a range of occupational health nursing topics. This review course illustrates how innovative educational delivery models can serve the needs of occupational health nurses challenged by geographic and time constraints. © 2015 The Author(s).

Modulation of eukaryotic cell apoptosis by members of the bacterial order Actinomycetales.

PubMed

Barry, Daniel P; Beaman, Blaine L

2006-10-01

Apoptosis, or programmed cell death, is normally responsible for the orderly elimination of aged or damaged cells, and is a necessary part of the homeostasis and development of multicellular organisms. Some pathogenic bacteria can disrupt this process by triggering excess apoptosis or by preventing it when appropriate. Either event can lead to disease. There has been extensive research into the modulation of host cell death by microorganisms, and several reviews have been published on the phenomenon. Rather than covering the entire field, this review focuses on the dysregulation of host cell apoptosis by members of the order Actinomycetales, containing the genera Corynebacterium, Mycobacterium, Rhodococcus, and Nocardia.

Prebiotic organic matter - Possible pathways for synthesis in a geological context

NASA Technical Reports Server (NTRS)

Chang, S.

1982-01-01

Models for the accretion of the earth, core formation, differentiation of the planet into core, mantle, crust, and atmosphere, and prebiotic synthesis of organic materials are reviewed. The development of the Haldane-Oparin and Urey models is traced, and the effect of accretion time on the outgassing process and the composition of the consequent atmosphere is examined. Model prebiotic atmospheres are calculated, the extent of equilibration of the primitive atmosphere is studied and the evolution of the atmosphere prior to organic chemical evolution is reviewed. Finally, experimental progress in synthesis of biological monomers and polymers under presumed early earth conditions is covered.

Apollo experience report: Power generation system

NASA Technical Reports Server (NTRS)

Bell, D., III; Plauche, F. M.

1973-01-01

A comprehensive review of the design philosophy and experience of the Apollo electrical power generation system is presented. The review of the system covers a period of 8 years, from conception through the Apollo 12 lunar-landing mission. The program progressed from the definition phase to hardware design, system development and qualification, and, ultimately, to the flight phase. Several problems were encountered; however, a technology evolved that enabled resolution of the problems and resulted in a fully manrated power generation system. These problems are defined and examined, and the corrective action taken is discussed. Several recommendations are made to preclude similar occurrences and to provide a more reliable fuel-cell power system.

Recent Progress in Discrete Dislocation Dynamics and Its Applications to Micro Plasticity

NASA Astrophysics Data System (ADS)

Po, Giacomo; Mohamed, Mamdouh S.; Crosby, Tamer; Erel, Can; El-Azab, Anter; Ghoniem, Nasr

2014-10-01

We present a self-contained review of the discrete dislocation dynamics (DDD) method for the numerical investigation of plasticity in crystals, focusing on recent development and implementation progress. The review covers the theoretical foundations of DDD within the framework of incompatible elasticity, its numerical implementation via the nodal method, the extension of the method to finite domains and several implementation details. Applications of the method to current topics in micro-plasticity are presented, including the size effects in nano-indentation, the evolution of the dislocation microstructure in persistent slip bands, and the phenomenon of dislocation avalanches in micro-pillar compression.

Role of carbon nanotubes in electroanalytical chemistry: a review.

PubMed

Agüí, Lourdes; Yáñez-Sedeño, Paloma; Pingarrón, José M

2008-08-01

This review covers recent advances in the development of new designs of electrochemical sensors and biosensors that make use of electrode surfaces modification with carbon nanotubes. Applications based on carbon nanotubes-driven electrocatalytic effects, and the construction and analytical usefulness of new hybrid materials with polymers or other nanomaterials will be treated. Moreover, electrochemical detection using carbon nanotubes-modified electrodes as detecting systems in separation techniques such as high performance liquid chromatography (HPLC) or capillary electrophoresis (CE) will be also considered. Finally, the preparation of electrochemical biosensors, including enzyme electrodes, immunosensors and DNA biosensors, in which carbon nanotubes play a significant role in their sensing performance will be separately considered.

Label Review Training: Module 1: Label Basics, Page 19

EPA Pesticide Factsheets

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. This section covers supplemental distributor labeling.

Conducting polymer-based electrochemical biosensors for neurotransmitters: A review.

PubMed

Moon, Jong-Min; Thapliyal, Neeta; Hussain, Khalil Khadim; Goyal, Rajendra N; Shim, Yoon-Bo

2018-04-15

Neurotransmitters are important biochemical molecules that control behavioral and physiological functions in central and peripheral nervous system. Therefore, the analysis of neurotransmitters in biological samples has a great clinical and pharmaceutical importance. To date, various methods have been developed for their assay. Of the various methods, the electrochemical sensors demonstrated the potential of being robust, selective, sensitive, and real time measurements. Recently, conducting polymers (CPs) and their composites have been widely employed in the fabrication of various electrochemical sensors for the determination of neurotransmitters. Hence, this review presents a brief introduction to the electrochemical biosensors, with the detailed discussion on recent trends in the development and applications of electrochemical neurotransmitter sensors based on CPs and their composites. The review covers the sensing principle of prime neurotransmitters, including glutamate, aspartate, tyrosine, epinephrine, norepinephrine, dopamine, serotonin, histamine, choline, acetylcholine, nitrogen monoxide, and hydrogen sulfide. In addition, the combination with other analytical techniques was also highlighted. Detection challenges and future prospective of the neurotransmitter sensors were discussed for the development of biomedical and healthcare applications. Copyright © 2017 Elsevier B.V. All rights reserved.

Biomedical coatings on magnesium alloys - a review.

PubMed

Hornberger, H; Virtanen, S; Boccaccini, A R

2012-07-01

This review comprehensively covers research carried out in the field of degradable coatings on Mg and Mg alloys for biomedical applications. Several coating methods are discussed, which can be divided, based on the specific processing techniques used, into conversion and deposition coatings. The literature review revealed that in most cases coatings increase the corrosion resistance of Mg and Mg alloys. The critical factors determining coating performance, such as corrosion rate, surface chemistry, adhesion and coating morphology, are identified and discussed. The analysis of the literature showed that many studies have focused on calcium phosphate coatings produced either using conversion or deposition methods which were developed for orthopaedic applications. However, the control of phases and the formation of cracks still appear unsatisfactory. More research and development is needed in the case of biodegradable organic based coatings to generate reproducible and relevant data. In addition to biocompatibility, the mechanical properties of the coatings are also relevant, and the development of appropriate methods to study the corrosion process in detail and in the long term remains an important area of research. Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Micro- and nanotechnologies in plankton research

NASA Astrophysics Data System (ADS)

Mohammed, Javeed Shaikh

2015-05-01

A better understanding of the vast range of plankton and their interactions with the marine environment would allow prediction of their large-scale impact on the marine ecosystem, and provide in-depth knowledge on pollution and climate change. Numerous technologies, especially lab-on-a-chip microsystems, are being used to this end. Marine biofouling is a global issue with significant economic consequences. Ecofriendly polymer nanotechnologies are being developed to combat marine biofouling. Furthermore, nanomaterials hold great potential for bioremediation and biofuel production. Excellent reviews covering focused topics in plankton research exist, with only a handful discussing both micro- and nanotechnologies. This work reviews both micro- and nanotechnologies applied to broad-ranging plankton research topics including flow cytometry, chemotaxis/toxicity assays, biofilm formation, marine antifouling/fouling-release surfaces and coatings, green energy, green nanomaterials, microalgae immobilization, and bioremediation. It is anticipated that developments in plankton research will see engineered exploitation of micro- and nanotechnologies. The current review is therefore intended to promote micro-/nanotechnology researchers to team up with limnologists/oceanographers, and develop novel strategies for understanding and green exploitation of the complex marine ecosystem.

Silage review: Factors affecting dry matter and quality losses in silages.

PubMed

Borreani, G; Tabacco, E; Schmidt, R J; Holmes, B J; Muck, R E

2018-05-01

An overview was made of dry matter (DM) and quality losses that occur during the ensiling process from the field through the feeding phase. The aim was to review the relevant published literature of the last 15 yr focusing on developments achieved after the publication of the book Silage Science and Technology. This review discusses the factors affecting DM and quality losses in terms of field and pre-ensiling conditions, respiration and temperature at ensiling, fermentation patterns, methods of covering and weighting the silage cover, and management of aerobic deterioration. The possibility of reducing DM and quality losses during the ensiling process requires knowledge of how to measure losses on farm and establish the status of the silage during the feed-out phase, implementing the most effective management practices to avoid air exposure during conservation and reduce silage aerobic deterioration during feeding. The paper concludes with future perspectives and recommended management practices to reduce losses and increase efficiency over the whole ensiling process in view of increasing sustainability of the livestock production chain. The Authors. Published by FASS Inc. and Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

The role of access policies in wireline shared resource projects

DOT National Transportation Integrated Search

2001-09-11

This report is a research review of potential safety implications of electronic billboards (EBBs) on driving safety. The review covers the interval from a similar review published in 1980 to the present. The present review focuses on the safety aspec...

45 CFR 160.308 - Compliance reviews.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Compliance reviews. 160.308 Section 160.308 Public... GENERAL ADMINISTRATIVE REQUIREMENTS Compliance and Investigations § 160.308 Compliance reviews. The Secretary may conduct compliance reviews to determine whether covered entities are complying with the...

Contemporary Cognitive Behavior Therapy: A Review of Theory, History, and Evidence.

PubMed

Thoma, Nathan; Pilecki, Brian; McKay, Dean

2015-09-01

Cognitive behavior therapy (CBT) has come to be a widely practiced psychotherapy throughout the world. The present article reviews theory, history, and evidence for CBT. It is meant as an effort to summarize the forms and scope of CBT to date for the uninitiated. Elements of CBT such as cognitive therapy, behavior therapy, and so-called "third wave" CBT, such as dialectical behavior therapy (DBT) and acceptance and commitment therapy (ACT) are covered. The evidence for the efficacy of CBT for various disorders is reviewed, including depression, anxiety disorders, personality disorders, eating disorders, substance abuse, schizophrenia, chronic pain, insomnia, and child/adolescent disorders. The relative efficacy of medication and CBT, or their combination, is also briefly considered. Future directions for research and treatment development are proposed.

Using glycome databases for drug discovery.

PubMed

Aoki-Kinoshita, Kiyoko F

2008-08-01

The glycomics field has made great advancements in the last decade due to technologies for their synthesis and analysis including carbohydrate microarrays. Accordingly, databases for glycomics research have also emerged and been made publicly available by many major institutions worldwide. This review introduces these and other useful databases on which new methods for drug discovery can be developed. The scope of this review covers current documented and accessible databases and resources pertaining to glycomics. These were selected with the expectation that they may be useful for drug discovery research. There is a plethora of glycomics databases that have much potential for drug discovery. This may seem daunting at first but this review helps to put some of these resources into perspective. Additionally, some thoughts on how to integrate these resources to allow more efficient research are presented.

A review of cost measures for the economic impact of domestic violence.

PubMed

Chan, Ko Ling; Cho, Esther Yin-Nei

2010-07-01

Although economic analyses of domestic violence typically guide decisions concerning resource allocation, allowing policy makers to make better informed decisions on how to prioritize and allocate scarce resources, the methods adopted to calculate domestic violence costs have varied widely from study to study. In particular, only a few studies have reviewed the cost measures of the economic impact of domestic violence. This article reviews and compares these measures by covering approaches to categorizing costs, the cost components, and ways to estimate them and recommends an integrated framework that brings the various approaches together. Some issues still need to be addressed when further developing measures such as including omitted but significant measures and expanding the time horizons of others. The implications for future study of domestic violence costs are discussed.

Chinese health care system and clinical epidemiology

PubMed Central

Sun, Yuelian; Gregersen, Hans; Yuan, Wei

2017-01-01

China has gone through a comprehensive health care insurance reform since 2003 and achieved universal health insurance coverage in 2011. The new health care insurance system provides China with a huge opportunity for the development of health care and medical research when its rich medical resources are fully unfolded. In this study, we review the Chinese health care system and its implication for medical research, especially within clinical epidemiology. First, we briefly review the population register system, the distribution of the urban and rural population in China, and the development of the Chinese health care system after 1949. In the following sections, we describe the current Chinese health care delivery system and the current health insurance system. We then focus on the construction of the Chinese health information system as well as several existing registers and research projects on health data. Finally, we discuss the opportunities and challenges of the health care system in regard to clinical epidemiology research. China now has three main insurance schemes. The Urban Employee Basic Medical Insurance (UEBMI) covers urban employees and retired employees. The Urban Residence Basic Medical Insurance (URBMI) covers urban residents, including children, students, elderly people without previous employment, and unemployed people. The New Rural Cooperative Medical Scheme (NRCMS) covers rural residents. The Chinese Government has made efforts to build up health information data, including electronic medical records. The establishment of universal health care insurance with linkage to medical records will provide potentially huge research opportunities in the future. However, constructing a complete register system at a nationwide level is challenging. In the future, China will demand increased capacity of researchers and data managers, in particular within clinical epidemiology, to explore the rich resources. PMID:28356772

Berberine and its derivatives: a patent review (2009 - 2012).

PubMed

Singh, Inder Pal; Mahajan, Shivani

2013-02-01

Berberine, a protoberberine alkaloid, and its derivatives exhibit a wide spectrum of pharmacological activities. It has been used in traditional Chinese medicine and Ayurvedic medicine and current research evidences support its use for various therapeutic areas. This review covers the patents on therapeutic activities of berberine and its derivatives in the years between 2009 and 2012. An extensive search was done to collect the patent information using European Patent Office database and SciFinder. The therapeutic areas covered include cancer, inflammation, infectious diseases, cardiovascular, metabolic disorders, and miscellaneous areas such as polycystic ovary syndrome, allergic diseases, and so on. Berberine along with its derivatives or in combination with other pharmaceutically active compounds or in the form of formulations has applications in various therapeutic areas such as cancer, inflammation, diabetes, depression, hypertension, and various infectious areas. Berberine has demonstrated wide physiological functions and has great potential to give a multipotent drug if some inherent problems on poor bioavailability and solubility are taken care of. Additionally, polyherbal formulations with berberine-containing plants as major ingredients can be successfully developed.

Emerging Drugs for Uveitis

PubMed Central

Larson, Theresa; Nussenblatt, Robert B.; Sen, H. Nida

2010-01-01

Importance of the Field Uveitis is a challenging disease covering both infectious and noninfectious conditions. The current treatment strategies are hampered by the paucity of randomized controlled trials (RCTs) and few trials comparing efficacy of different agents. Areas Covered in this Review This review describes the current and future treatments of uveitis. A literature search was performed in PUBMED from 1965 to 2010 on drugs treating ocular inflammation with emphasis placed on more recent, larger studies. What the Reader Will Gain Readers should gain a basic understanding of current treatment strategies beginning with corticosteroids and transitioning to steroid sparing agents. Steroid sparing agents include the antimetabolites which include methotrexate, azathioprine, and mycophenolate mofetil; the calcineurin inhibitors which include cyclosporine, tacrolimus; alkylating agents which include cyclophosphamide and chlorambucil; and biologics which include the TNF-α inhibitors infliximab, adalimumab, and etanercept; daclizumab, interferon α2a, and rituximab. Take Home Message Newer agents are typically formulated from existing drugs or developed based on new advances in immunology. Future treatment will require a better understanding of the mechanisms involved in autoimmune diseases and better delivery systems in order to provide targeted treatment with minimal side effects. PMID:21210752

Robot-like dexterity without computers and motors: a review of hand-held laparoscopic instruments with wrist-like tip articulation

PubMed Central

Anderson, Patrick L.; Lathrop, Ray A.; Webster, Robert J.

2018-01-01

Introduction Conventional manual laparoscopic instruments for minimally invasive surgery have limited dexterity within the patient, making procedures challenging. Surgical robotic systems offer enhanced articulation, but at substantial financial costs. This has motivated the development of high-dexterity, low-cost laparoscopic instruments. Areas covered This article reviews both commercial and academic results on creating fully mechanical (i.e. non-robotic) laparoscopic instruments that provide wrists or wrist-like dexterity within the patient. We review the state of the art in the development of these mechanical instruments, focusing on the surgeon interface, wrist mechanism, and the kinematic mapping between the two. Expert commentary Current articulated mechanical laparoscopic instruments exhibit a wide range of designs, with no clear consensus on what makes such devices easy to use. As these technologies mature, user studies are needed to determine surgeon preferences. Articulated, low-cost instruments have the potential to impact the minimally invasive surgery market if they provide compelling benefits to surgeons. PMID:26808896

Recent Progress in the Development of Conducting Polymer-Based Nanocomposites for Electrochemical Biosensors Applications: A Mini-Review.

PubMed

Naseri, Maryam; Fotouhi, Lida; Ehsani, Ali

2018-06-01

Among various immobilizing materials, conductive polymer-based nanocomposites have been widely applied to fabricate the biosensors, because of their outstanding properties such as excellent electrocatalytic activity, high conductivity, and strong adsorptive ability compared to conventional conductive polymers. Electrochemical biosensors have played a significant role in delivering the diagnostic information and therapy monitoring in a rapid, simple, and low cost portable device. This paper reviews the recent developments in conductive polymer-based nanocomposites and their applications in electrochemical biosensors. The article starts with a general and concise comparison between the properties of conducting polymers and conducting polymer nanocomposites. Next, the current applications of conductive polymer-based nanocomposites of some important conducting polymers such as PANI, PPy, and PEDOT in enzymatic and nonenzymatic electrochemical biosensors are overviewed. This review article covers an 8-year period beginning in 2010. © 2018 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recent Advances in the Chemistry and Biology of Podophyllotoxins.

PubMed

Yu, Xiang; Che, Zhiping; Xu, Hui

2017-04-03

Podophyllotoxin and its related aryltetralin cyclolignans belong to a family of important products that exhibit various biological properties (e.g., cytotoxic, insecticidal, antifungal, antiviral, anti-inflammatory, neurotoxic, immunosuppressive, antirheumatic, antioxidative, antispasmogenic, and hypolipidemic activities). This Review provides a survey of podophyllotoxin and its analogues isolated from plants. In particular, recent developments in the elegant total chemical synthesis, structural modifications, biosynthesis, and biotransformation of podophyllotoxin and its analogues are summarized. Moreover, a deoxypodophyllotoxin-based chemosensor for selective detection of mercury ion is described. In addition to the most active podophyllotoxin derivatives in each series against human cancer cell lines and insect pests listed in the tables, the structure-activity relationships of podophyllotoxin derivatives as cytotoxic and insecticidal agents are also outlined. Future prospects and further developments in this area are covered at the end of the Review. We believe that this Review will provide necessary information for synthetic, medicinal, and pesticidal chemistry researchers who are interested in the chemistry and biology of podophyllotoxins. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Analysis of environmental issues related to small-scale hydroelectric development IV: fish mortality resulting from turbine passage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turbak, S. C.; Reichle, D. R.; Shriner, C. R.

1981-01-01

This document presents a state-of-the-art review of literature concerning turbine-related fish mortality. The review discusses conventional and, to a lesser degree, pumped-storage (reversible) hydroelectric facilities. Much of the research on conventional facilities discussed in this report deals with studies performed in the Pacific Northwest and covers both prototype and model studies. Research conducted on Kaplan and Francis turbines during the 1950s and 1960s has been extensively reviewed and is discussed. Very little work on turbine-related fish mortality has been undertaken with newer turbine designs developed for more modern small-scale hydropower facilities; however, one study on a bulb unit (Kaplan runner)more » has recently been released. In discussing turbine-related fish mortality at pumped-storage facilities, much of the literature relates to the Ludington Pumped Storage Power Plant. As such, it is used as the principal facility in discussing research concerning pumped storage.« less

An overview of adjuvants utilized in prophylactic vaccine formulation as immunomodulators.

PubMed

Chauhan, Nidhi; Tiwari, Sukirti; Iype, Tessy; Jain, Utkarsh

2017-05-01

Development of efficient and cost effective vaccines have been recognized as the primary concern to improve the overall healthcare in a country. In order to achieve this goal, more improved and powerful adjuvants need to be developed. Lacking in the self-adjuvanting immuno-modulatory constituents, vaccines exhibit lower immunogenicity. Combining potent adjuvants with vaccines is the most appropriate method to enhance the efficacy of the vaccines. Hence, this review is focussed on the most potent adjuvants for the formulation of vaccines. Areas covered: This review focuses on Oil-based emulsions, Mineral compounds, Liposomes, Bacterial products, ISCOMs and most recently used nanomaterials as adjuvants for enhancing the antigenicity of vaccines. Furthermore, this review explains the immunological response elicited by various particles. Moreover, case studies are incorporated providing an in depth analyses of various adjuvant-containing vaccines which are currently used. Expert commentary: Enhanced fundamental knowledge about the adjuvants and their immuno-stimulatory capabilities and delivery mechanisms will facilitate the rational designing of prophylactic vaccines with better efficacy.

Optically pumped VECSELs: review of technology and progress

NASA Astrophysics Data System (ADS)

Guina, M.; Rantamäki, A.; Härkönen, A.

2017-09-01

Vertical-external-cavity surface-emitting lasers (VECSELs) are the most versatile laser sources, combining unique features such as wide spectral coverage, ultrashort pulse operation, low noise properties, high output power, high brightness and compact form-factor. This paper reviews the recent technological developments of VECSELs in connection with the new milestones that continue to pave the way towards their use in numerous applications. Significant attention is devoted to the fabrication of VECSEL gain mirrors in challenging wavelength regions, especially at the yellow and red wavelengths. The reviewed fabrication approaches address wafer-bonded VECSEL structures as well as the use of hybrid mirror structures. Moreover, a comprehensive summary of VECSEL characterization methods is presented; the discussion covers different stages of VECSEL development and different operation regimes, pointing out specific characterization techniques for each of them. Finally, several emerging applications are discussed, with emphasis on the unique application objectives that VECSELs render possible, for example in atom and molecular physics, dermatology and spectroscopy.

Fibroblast growth factor receptor inhibitors.

PubMed

Kumar, Suneel B V S; Narasu, Lakshmi; Gundla, Rambabu; Dayam, Raveendra; J A R P, Sarma

2013-01-01

Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates. The fibroblast growth factor (FGF) and its receptor (FGFR) provide another pathway that seems critical to monitoring angiogenesis. Recent findings suggest that FGFR mediates signaling, regulates the PKM2 activity, and plays a crucial role in cancer metabolism. The current review also covers the recent findings on the role of FGFR1 in cancer metabolism. This paper reviews the progress, mechanism, and binding modes of recently known kinase inhibitors such as PD173074, SU series and other inhibitors still under clinical development. Some of the structural classes that will be highlighted in this review include Pyrido[2,3-d]pyrimidines, Indolin- 2-one, Pyrrolo[2,1-f][1,2,4]triazine, Pyrido[2,3-d]pyrimidin-7(8H)-one, and 1,6- Naphthyridin-2(1H)-ones.

Theoretical Methods of Domain Structures in Ultrathin Ferroelectric Films: A Review

PubMed Central

Liu, Jianyi; Chen, Weijin; Wang, Biao; Zheng, Yue

2014-01-01

This review covers methods and recent developments of the theoretical study of domain structures in ultrathin ferroelectric films. The review begins with an introduction to some basic concepts and theories (e.g., polarization and its modern theory, ferroelectric phase transition, domain formation, and finite size effects, etc.) that are relevant to the study of domain structures in ultrathin ferroelectric films. Basic techniques and recent progress of a variety of important approaches for domain structure simulation, including first-principles calculation, molecular dynamics, Monte Carlo simulation, effective Hamiltonian approach and phase field modeling, as well as multiscale simulation are then elaborated. For each approach, its important features and relative merits over other approaches for modeling domain structures in ultrathin ferroelectric films are discussed. Finally, we review recent theoretical studies on some important issues of domain structures in ultrathin ferroelectric films, with an emphasis on the effects of interfacial electrostatics, boundary conditions and external loads. PMID:28788198

Potential value of systematic reviews of qualitative evidence in informing user-centered health and social care: findings from a descriptive overview.

PubMed

Dalton, Jane; Booth, Andrew; Noyes, Jane; Sowden, Amanda J

2017-08-01

Systematic reviews of quantitative evidence are well established in health and social care. Systematic reviews of qualitative evidence are increasingly available, but volume, topics covered, methods used, and reporting quality are largely unknown. We provide a descriptive overview of systematic reviews of qualitative evidence assessing health and social care interventions included on the Database of Abstracts of Reviews of Effects (DARE). We searched DARE for reviews published between January 1, 2009, and December 31, 2014. We extracted data on review content and methods, summarized narratively, and explored patterns over time. We identified 145 systematic reviews conducted worldwide (64 in the UK). Interventions varied but largely covered treatment or service delivery in community and hospital settings. There were no discernible patterns over time. Critical appraisal of primary studies was conducted routinely. Most reviews were poorly reported. Potential exists to use systematic reviews of qualitative evidence when driving forward user-centered health and social care. We identify where more research is needed and propose ways to improve review methodology and reporting. Copyright © 2017 Elsevier Inc. All rights reserved.

76 FR 73592 - Certain Lined Paper Products From Indonesia: Final Results of the Expedited Sunset Review of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... binders board, a spine strip, and cover wrap). Subject merchandise may or may not contain any combination... strip, and cover wrap; newspapers; pictures and photographs; desk and wall calendars and organizers... spiral, or helical, wire and with plastic front and rear covers made of a blended polyolefin plastic...

Do cover crops increase or decrease nitrous oxide emissions? A meta-analysis

USDA-ARS?s Scientific Manuscript database

Few studies have examined the factors that affect the impact of cover crops on nitrous oxide emissions. A meta-analysis of the data obtained from twenty-six peer reviewed articles was conducted using the natural log of the nitrous oxide flux with a cover crop divided by the nitrous oxide flux withou...

45 CFR 2540.204 - What procedures must I follow in conducting a National Service Criminal History Check for a...

Code of Federal Regulations, 2012 CFR

2012-10-01

... National Service Criminal History Check for a covered position? 2540.204 Section 2540.204 Public Welfare... What procedures must I follow in conducting a National Service Criminal History Check for a covered...'s review of the individual's criminal history, if any; (d) Provide a reasonable opportunity for the...

45 CFR 2540.204 - What procedures must I follow in conducting a National Service Criminal History Check for a...

Code of Federal Regulations, 2011 CFR

2011-10-01

... National Service Criminal History Check for a covered position? 2540.204 Section 2540.204 Public Welfare... What procedures must I follow in conducting a National Service Criminal History Check for a covered...'s review of the individual's criminal history, if any; (d) Provide a reasonable opportunity for the...