Science.gov

Sample records for reviewing procedure pri

  1. In situ measurement of Scots pine needle PRI.

    PubMed

    Mõttus, Matti; Hernández-Clemente, Rocío; Perheentupa, Viljami; Markiet, Vincent

    2017-01-01

    The Photochemical Reflectance Index (PRI) calculated from narrow-band spectral reflectance data is a vegetation index which is increasingly used as an indicator of photosynthetic activity. The leaf-level link between the status of photosynthetic apparatus and PRI has been robustly established under controlled light conditions. However, when a whole canopy is measured instantaneously, the PRI signal is heavily modified by vegetation structure and local variations in incident light conditions. To apply PRI for monitoring the photosynthesis of whole canopies under natural conditions, these large-scale measurements need to be validated against simultaneous leaf PRI. Unfortunately, PRI changes dynamically with incident light and has a large natural variation. No generally accepted procedure exists today for determining the PRI of canopy elements in situ. We present a successful procedure for in situ measurements of needle PRI. We describe, characterize and test an optical measurement protocol and demonstrate its applicability in field conditions. The measurement apparatus consisted of a light source, needle clip, spectroradiometer and a controlling computer. The light level inside the clip was approximately two-thirds of that on sunlit needle surfaces at midday. During each measurement the needle was inserted into the clip for approximately 5 s. We found no near-instantaneous changes (sub-second scale jumps) in PRI during the measurements. The time constants for PRI variation in light to full shade acclimations were approximately 10 s. The procedure was successfully applied to monitor the greening-up of Scots pine trees. We detected both facultative (diurnal) PRI changes of 0.02 (unitless) and constitutive (seasonal) variations of 0.1. In order to reliably detect the facultative PRI change of 0.02, 20 needles need to be sampled from both sunlit and shaded locations. We established a robust procedure for irradiance-dependent leaf (needle) PRI measurements, facilitating

  2. PriMux

    SciTech Connect

    2010-08-31

    PriMux is used to compute sets of compatible Polymerase Chain Reaction (PCR)signatures that can be used for detecting the presence of biological species in a small sample of material. Before use, the computed signatures must be empirically tested in a wet lab.

  3. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  4. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  5. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  6. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  7. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  8. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  9. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  10. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  11. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  12. 48 CFR 242.7203 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... contractor's failure to meet one or more of the MMAS system criteria in the clause at 252.242-7004, Material... Management and Accounting System 242.7203 Review procedures. (a) Criteria for conducting reviews. Conduct...

  13. 49 CFR 601.47 - Review Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Review Procedures. 601.47 Section 601.47 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION... Transportation Systems § 601.47 Review Procedures. (a) FTA reserves the right to reopen any docket and reconsider...

  14. 7 CFR 28.66 - Review procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Reviews § 28.66 Review... 7 Agriculture 2 2010-01-01 2010-01-01 false Review procedure. 28.66 Section 28.66 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections,...

  15. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  16. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  17. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  18. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  19. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  20. 48 CFR 242.7203 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... experience and current vulnerability. (b) Qualifying sales. Qualifying sales are sales for which cost or... and/or cost accounting system; and (iv) Issue cautions to contracting activities regarding the award... Management and Accounting System 242.7203 Review procedures. (a) Criteria for conducting reviews. Conduct...

  1. Epilepsy and dental procedures. A review.

    PubMed

    Vorkas, Charles K; Gopinathan, Manju K; Singh, Anuradha; Devinsky, Orrin; Lin, Louis M; Rosenberg, Paul A

    2008-03-01

    This paper is a review of the dental management of patients with epilepsy. It includes discussion of the effects anti-epileptic drugs have on dental procedures and addresses complications and side effects of these drugs. A clinical case photo is presented to show gingival hyperplasia, along with four tables on which common antiepileptic medications are enumerated.

  2. 13 CFR 117.10 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Review procedures. 117.10 Section 117.10 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR ACTIVITIES OF SBA-EFFECTUATION OF THE AGE DISCRIMINATION ACT OF 1975, AS AMENDED §...

  3. Year 2000 TWRS Maintenance procedure review report

    SciTech Connect

    ADAMS, M.R.

    1999-02-24

    A concern exists that some equipment in use might contain microprocessors that are dependent upon a time date function. The majority of the software programming for microprocessors has only utilized a 2 digit identifier for the year. With the approach of the year 2000, (Y2K), there is concern that the date function will not be correctly recognized and some functions will not operate properly. TWRS maintenance procedures have been reviewed to identify equipment components that may not be Y2K compliant. Engineering judgment was utilized to eliminate procedures and equipment that is obviously not impacted by Y2K.

  4. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Peer review procedures. 34.102 Section 34.102 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.102 Peer review procedures. The OJJDP peer review process is contained in an OJJDP “Peer...

  5. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Peer review procedures. 34.102 Section 34.102 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.102 Peer review procedures. The OJJDP peer review process is contained in an OJJDP “Peer...

  6. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Peer review procedures. 34.102 Section 34.102 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.102 Peer review procedures. The OJJDP peer review process is contained in an OJJDP “Peer...

  7. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Peer review procedures. 34.102 Section 34.102 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.102 Peer review procedures. The OJJDP peer review process is contained in an OJJDP “Peer...

  8. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Peer review procedures. 34.102 Section 34.102 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.102 Peer review procedures. The OJJDP peer review process is contained in an OJJDP “Peer...

  9. Remotely sensing the photochemical reflectance index, PRI

    NASA Astrophysics Data System (ADS)

    Vanderbilt, Vern; Daughtry, Craig; Dahlgren, Robert

    2015-09-01

    In remote sensing, the Photochemical Reflectance Index (PRI) provides insight into physiological processes occurring inside leaves in a plant stand. Developed by1,2, PRI evolved from laboratory reflectance measurements of individual leaves. Yet in a remotely sensed image, a pixel measurement may include light from both reflecting and transmitting leaves. We compared values of PRI based upon polarized reflectance and transmittance measurements of water and nutrient stressed leaves. Our results show the polarized leaf surface reflection should be removed when calculating PRI and that the leaf physiology information is in leaf interior reflectance, not leaf transmittance.

  10. MISR Browse Images: Puerto Rico Dust Experiment (PRiDE)

    Atmospheric Science Data Center

    2013-04-02

    MISR Browse Images: Puerto Rico Dust Experiment (PRiDE) These MISR Browse images provide ... overview of the region observed during the Puerto Rico Dust Experiment (PRiDE) field campaign. PRiDE was a study of the radiative, ...

  11. Pectoralis major tendon rupture. Surgical procedures review.

    PubMed Central

    Merolla, Giovanni; Paladini, Paolo; Campi, Fabrizio; Porcellini, Giuseppe

    2012-01-01

    Summary Pectoralis major (PM) muscle is the powerful dynamic stabiliser of the shoulder that acts as a flexor, adductor and internal rotator. The rupture of the PM tendon is a relatively rare injury that was firstly described in a French boy by Patissier in 1822 and later, in 1861, by Letenneur who reported another similiar case. To date, over 200 cases have been published. In this article we describe the clinical anatomy and the mechanism of injuries of PM and we review the surgical procedures for acute and chronic ruptures. PMID:23738281

  12. 4 CFR 28.90 - Board procedures; judicial review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 4 Accounts 1 2013-01-01 2013-01-01 false Board procedures; judicial review. 28.90 Section 28.90 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL... ACCOUNTABILITY OFFICE Procedures Board Decisions, Attorney's Fees and Judicial Review § 28.90 Board procedures...

  13. Linking Knowledge and Action: PRI's Community Consultant.

    ERIC Educational Resources Information Center

    Spencer, Gregory P.

    Within the Partnership for Rural Improvement (PRI), community consultants operate within three complex sets of relationships: client groups, the organizational structure of PRI, and the local operational base. Community consultants are responsible for developing and facilitating rural development and for providing assistance in community and…

  14. Linking Knowledge and Action: PRI's Community Consultant.

    ERIC Educational Resources Information Center

    Spencer, Gregory P.

    Within the Partnership for Rural Improvement (PRI), community consultants operate within three complex sets of relationships: client groups, the organizational structure of PRI, and the local operational base. Community consultants are responsible for developing and facilitating rural development and for providing assistance in community and…

  15. [Mood induction procedures: a critical review].

    PubMed

    Gilet, A-L

    2008-06-01

    For a long period in the history of psychological research, emotion and cognition have been studied independently, as if one were irrelevant to the other. The renewed interest of researchers for the study of the relations between cognition and emotion has led to the development of a range of laboratory methods for inducing temporary mood states. This paper aims to review the main mood induction procedures allowing the induction of a negative mood as well as a positive mood, developed since the pioneer study of Schachter and Singer [Psychol Rev 69 (1962) 379-399] and to account for the usefulness and problems related to the use of such techniques. The first part of this paper deals with the detailed presentation of some of the most popular mood induction procedures according to their type: simple (use of only one mood induction technique) or combined (association of two or more techniques at once). The earliest of the modern techniques is the Velten Mood Induction Procedure [Behav Res Ther 6 (1968) 473-482], which involves reading aloud sixty self-referent statements progressing from relative neutral mood to negative mood or dysphoria. Some researchers have varied the procedure slightly by changing the number of the statements [Behav Res Ther 21 (1983) 233-239, Br J Clin Psychol 21 (1982) 111-117, J Pers Soc Psychol 35 (1977) 625-636]. Various other mood induction procedures have been developed including music induction [Cogn Emotion 11 (1997) 403-432, Br J Med Psychol 55 (1982) 127-138], film clip induction [J Pers Soc Psychol 20 (1971) 37-43, Cogn Emotion 7 (1993) 171-193, Rottenberg J, Ray RR, Gross JJ. Emotion elicitation using films. In: Coan JA, Allen JJB, editors. The handbook of emotion elicitation and assessment. New York: Oxford University Press, 2007], autobiographical recall [J Clin Psychol 36 (1980) 215-226, Jallais C. Effets des humeurs positives et négatives sur les structures de connaissances de type script. Thèse de doctorat non publi

  16. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  17. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any adverse...

  18. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any adverse...

  19. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any adverse...

  20. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any adverse...

  1. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  2. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  3. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  4. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  5. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  6. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval...

  7. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval...

  8. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval...

  9. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval...

  10. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval...

  11. 42 CFR 431.980 - Eligibility review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Estimating Improper Payments in Medicaid and CHIP § 431.980 Eligibility review procedures. (a) Active case reviews. The agency must verify eligibility for all selected active cases for Medicaid and CHIP for the... must review all selected negative cases for Medicaid and CHIP for the review month to determine whether...

  12. 42 CFR 431.980 - Eligibility review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Estimating Improper Payments in Medicaid and CHIP § 431.980 Eligibility review procedures. (a) Active case reviews. The agency must verify eligibility for all selected active cases for Medicaid and CHIP for the... must review all selected negative cases for Medicaid and CHIP for the review month to determine whether...

  13. 42 CFR 431.980 - Eligibility review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Estimating Improper Payments in Medicaid and CHIP § 431.980 Eligibility review procedures. (a) Active case reviews. The agency must verify eligibility for all selected active cases for Medicaid and CHIP for the... must review all selected negative cases for Medicaid and CHIP for the review month to determine whether...

  14. 42 CFR 431.980 - Eligibility review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Estimating Improper Payments in Medicaid and CHIP § 431.980 Eligibility review procedures. (a) Active case reviews. The agency must verify eligibility for all selected active cases for Medicaid and CHIP for the... must review all selected negative cases for Medicaid and CHIP for the review month to determine whether...

  15. 7 CFR 28.66 - Review procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... review shall cover all of the quality factors for which the original determination was made. Requests for... issued such memorandum or the Quality Control System. Requests for reviews of Form C determinations shall be filed with, and the reviews made by, the Quality Control System. Redrawn samples shall be required...

  16. 7 CFR 28.66 - Review procedure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... review shall cover all of the quality factors for which the original determination was made. Requests for... issued such memorandum or the Quality Control System. Requests for reviews of Form C determinations shall be filed with, and the reviews made by, the Quality Control System. Redrawn samples shall be required...

  17. 7 CFR 28.66 - Review procedure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... review shall cover all of the quality factors for which the original determination was made. Requests for... issued such memorandum or the Quality Control System. Requests for reviews of Form C determinations shall be filed with, and the reviews made by, the Quality Control System. Redrawn samples shall be required...

  18. 7 CFR 28.66 - Review procedure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... review shall cover all of the quality factors for which the original determination was made. Requests for... issued such memorandum or the Quality Control System. Requests for reviews of Form C determinations shall be filed with, and the reviews made by, the Quality Control System. Redrawn samples shall be required...

  19. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  20. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  1. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  2. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  3. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  4. 75 FR 15689 - Streamlined Procedure for Appeal Brief Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... United States Patent and Trademark Office Streamlined Procedure for Appeal Brief Review AGENCY: United... Trademark Office (USPTO) is streamlining the procedure for the review of appeal briefs to increase the... responsibility for determining whether appeal briefs filed in patent applications comply with the applicable...

  5. Program Review/Evaluation Policy and Procedures.

    ERIC Educational Resources Information Center

    Colorado Northwestern Community Coll., Rangely.

    At Colorado Northwestern Community College (CNCC), all educational programs, as well as student services and support functions, are formally reviewed/evaluated in depth at least once every five years. This nine-part outline, providing a step-by-step description of the program review process at CNCC, includes the following sections: (1) the value…

  6. 20 CFR 410.704 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-BLACK LUNG BENEFITS (1969- ) Rules for the Review of Denied and Pending Claims Under the Black Lung... establishes entitlement to benefits under the BLBRA of 1977. Evidence on file is information in the black...

  7. 20 CFR 410.704 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-BLACK LUNG BENEFITS (1969- ) Rules for the Review of Denied and Pending Claims Under the Black Lung... establishes entitlement to benefits under the BLBRA of 1977. Evidence on file is information in the black...

  8. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  9. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  10. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  11. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  12. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  13. 19 CFR 351.221 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) questionnaires requesting factual information for the review; (3) Conduct, if appropriate, a verification under... the case may be); and (ii) Normally will send questionnaires no later than 30 days after the date of... that expedited action is warranted; and (iii) May refrain from issuing questionnaires under...

  14. Procedural and Conceptual Knowledge: Adults Reviewing Fractions

    ERIC Educational Resources Information Center

    Baker, William J.; Czarnocha, Bronislaw; Dias, Olen; Doyle, Kathleen; Kennis, James R.

    2012-01-01

    In the United States a majority of the students who enroll in community colleges require a review of secondary math before they are eligible for college level mathematics. In the pre-algebra course, that has a high drop-out rate, the most difficult topic for students is fractions. In order to better understand the fraction concept, Kieren…

  15. Radiofrequency energy-induced heating during MR procedures: a review.

    PubMed

    Shellock, F G

    2000-07-01

    During an MR procedure, most of the transmitted RF power is transformed into heat within the patient's tissue as a result of resistive losses. Not surprisingly, the primary bioeffects associated with the RF radiation used for MR procedures are directly related to the thermogenic qualities of this electromagnetic field. This review article discusses the characteristics of RF energy-induced heating associated with MR procedures, with an emphasis on thermal and other physiologic responses observed in human subjects.

  16. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES § 215.18...

  17. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES § 215.18...

  18. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES § 215.18...

  19. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES § 215.18...

  20. 41 CFR 109-28.5004 - Justification and review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Management Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS SUPPLY AND... Justification and review procedures. Procedures shall provide for the following: (a) The original decision to... support the need for retention of the equipment. This justification will cite the project for which...

  1. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES § 215.18...

  2. Remotely Sensing the Photochemical Reflectance Index (PRI)

    NASA Technical Reports Server (NTRS)

    Vanderbilt, Vern

    2015-01-01

    In remote sensing, the Photochemical Reflectance Index (PRI) provides insight into physiological processes occurring inside the leaves in a stand of plants. Developed by Gamon et al., (1990 and 1992), PRI evolved from laboratory measurements of the reflectance of individual leaves (Bilger et al.,1989). Yet in a remotely sensed image, a pixel measurement may include light from both reflecting and transmitting leaves. We conducted laboratory experiments comparing values of PRI based upon polarized reflectance and transmittance measurements of water and nutrient stressed leaves. We illuminated single detached leaves using a current controlled light source (Oriel model 66881) and measured the leaf weight using an analytical balance (Mettler model AE 260) and the light reflected and transmitted by the leaf during dry down using two Analytical Spectral Devices spectroradiometers. Polarizers on the incident and reflected light beams allowed us to divide the leaf reflectance into two parts: a polarized surface reflectance and a non-polarized 'leaf interior' reflectance. Our results underscore the importance when calculating PRI of removing the leaf surface reflection, which contains no information about physiological processes ongoing in the leaf interior. The results show that the leaf physiology information is in the leaf interior reflectance, not the leaf transmittance. Applied to a plant stand, these results suggest use of polarization measurements in sun-view directions that minimize the number of sunlit transmitting leaves in the sensor field of view.

  3. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract publication... Clauses 1552.237-70 Contract publication review procedures. As prescribed in 1537.110, insert the following contract clause when the products of the contract are subject to contract publication review...

  4. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract publication... Clauses 1552.237-70 Contract publication review procedures. As prescribed in 1537.110, insert the following contract clause when the products of the contract are subject to contract publication review...

  5. 29 CFR 801.69 - Procedures for initiating review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Vacation of Decision and Order of Administrative Law Judge § 801.69 Procedures for initiating review. (a) Within twenty (20) days after the date of the decision of the Administrative Law Judge, the respondent... which review is sought. A copy of the Decision and Order of the Administrative Law Judge shall...

  6. Differential interference of vitamin D analogs PRI-1906, PRI-2191, and PRI-2205 with the renewal of human colon cancer cells refractory to treatment with 5-fluorouracil.

    PubMed

    Kotlarz, Agnieszka; Przybyszewska, Małgorzata; Swoboda, Paweł; Miłoszewska, Joanna; Grygorowicz, Monika Anna; Kutner, Andrzej; Markowicz, Sergiusz

    2016-04-01

    This study was aimed to determine whether hypocalcemic analogs of active forms of vitamins D modulate expression of genes related to stem-like phenotype in colon cancer cell lines HT-29 and HCT-116 undergoing renewal after the treatment with 5-fluorouracil (5-FU). Both lines express vitamin D receptor, but differ in differentiation stage and vitamin D sensitivity. Cells that resisted the 5-FU exposure were treated with synthetic analog of 1,25-dihydroxyvitamin D2 (PRI-1906) and analogs of 1,25-dihydroxyvitamin D3 (PRI-2191 and PRI-2205). Proliferative activity was more profoundly affected by vitamin D analogs in HT-29/5-FU than in HCT-116/5-FU cells. In HT-29/5-FU cells, analogs PRI-1906 and PRI-2191 downregulated the expression of genes related to survival, re-growth, and invasiveness during renewal, while PRI-2205 increased expression of genes related to differentiation only. In HCT-116/5-FU cells, PRI-2191 decreased the expression of stemness- and angiogenesis-related genes, whereas PRI-1906 augmented their expression. The effects in HCT-116/5-FU cells were observed at higher concentrations of the analogs than those used for HT-29/5-FU cells. Out of the series of analogs studied, PRI-2191 might be used to counteract the renewal of both moderately and poorly differentiated cancer cells following conventional treatment.

  7. 76 FR 4933 - Environmental Review Procedures for Entities Assuming HUD Environmental Review Responsibilities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Responsibilities; Notice of Proposed Information Collection: Comment Request AGENCY: Office of the Assistant...: Environmental Review Procedures for Entities Assuming HUD Environmental Responsibilities. OMB Control...

  8. A review of the EXIT (Ex utero Intrapartum Treatment) procedure.

    PubMed

    Abraham, R J; Sau, A; Maxwell, D

    2010-01-01

    The EXIT (Ex utero Intrapartum Treatment) procedure is done in cases where difficulty is anticipated in neonatal airway establishment at delivery and is done at the time of caesarean section. The partially delivered fetus is maintained on placental circulation while airway is established and this is carried out by a multidisciplinary team. In this paper, we review the indications, the maternal and fetal considerations of the procedure and the results and outcomes. The review highlights the fact that the benefits far outweigh the risks and that the risk of postpartum haemorrhage is more theoretical than real. As technology improves and more anomalies are diagnosed during the antenatal period, the EXIT procedure can be performed with good results after carefully considering the ethical issues. We have performed a MEDLINE search by using the keywords EXIT, CHAOS, fetal surgery, fetal neck masses and ex utero intrapartum treatment. As there are not many large studies, we have also reviewed smaller case series and case reports.

  9. Standard Review Plan Update and Development Program. Implementing Procedures Document

    SciTech Connect

    Not Available

    1992-05-01

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures.

  10. Standard Review Plan Maintenance Program implementing procedures document

    SciTech Connect

    1996-11-01

    The implementing Procedures Document (IPD) was developed by the Inspection Program Projects Branch, Office of Nuclear Reactor Regulation, with assistance from Pacific Northwest National Laboratory, for the Standard Review Plan Maintenance Program (SRP-MP). The SRP-MP was established to maintain the Standard Review Plan (SRP) on an on-going basis. The IPD provides guidance, including an overall approach and procedures, for SRP-MP tasks. The objective of the IPD is to ensure that modifications to SRP need to reflect current NRC requirements and guidance are identified and that a consistent methodology is used to develop and revise SRP sections.

  11. 49 CFR 802.14 - Review procedure and judicial review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... TRANSPORTATION SAFETY BOARD RULES IMPLEMENTING THE PRIVACY ACT OF 1974 Review of Initial Adverse Determination..., DC 20594, and shall contain a statement on the envelope and in the appeal: “Appeal from Privacy Act... envelope, “Privacy Act Statement of Disagreement.” (2) The Director, Bureau of Administration, or...

  12. 44 CFR 8.4 - Mandatory declassification review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... review procedures. 8.4 Section 8.4 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NATIONAL SECURITY INFORMATION § 8.4 Mandatory... section. (3) If the ISOC denies the appeal, in part or in its entirety, then it will forward the appeal...

  13. 44 CFR 8.4 - Mandatory declassification review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... review procedures. 8.4 Section 8.4 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NATIONAL SECURITY INFORMATION § 8.4 Mandatory... section. (3) If the ISOC denies the appeal, in part or in its entirety, then it will forward the appeal...

  14. 42 CFR 431.980 - Eligibility review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... procedures as of the review month and identify payments made on behalf of such beneficiary or family for... of such beneficiary or family in the first 30 days of eligibility. (B) If the last action occurred... payments made on behalf of the beneficiary or family for services received in the sample month. (iii)...

  15. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Policy review requirements and procedures. 435.23 Section 435.23 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH...

  16. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Policy review requirements and procedures. 435.23 Section 435.23 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH...

  17. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Safety review requirements and procedures. 435.33 Section 435.33 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH...

  18. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Safety review requirements and procedures. 435.33 Section 435.33 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH...

  19. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing.... Such grower may forward with the request any pertinent material for consideration of such grower's...

  20. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... review procedures. 1552.237-70 Section 1552.237-70 Federal Acquisition Regulations System ENVIRONMENTAL... Contracting Officer in writing. (c) The Contractor may publish, in a scientific journal, material resulting... for publication. (2) The Contractor shall include the following statement in a journal article...

  1. 29 CFR 500.264 - Procedures for initiating review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Order of Administrative Law Judge § 500.264 Procedures for initiating review. (a) Within twenty (20) days after the date of the decision of the Administrative Law Judge, the respondent, the Administrator.... A copy of the Decision and Order of the Administrative Law Judge shall be attached to the...

  2. 41 CFR 109-28.5004 - Justification and review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROCUREMENT 28-STORAGE AND DISTRIBUTION 28.50-Management of Equipment Held for Future Projects § 109-28.5004... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Justification and review procedures. 109-28.5004 Section 109-28.5004 Public Contracts and Property Management Federal...

  3. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF...

  4. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF...

  5. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF...

  6. Hypnosis before diagnostic or therapeutic medical procedures: a systematic review.

    PubMed

    Cheseaux, Nicole; de Saint Lager, Alix Juillet; Walder, Bernhard

    2014-01-01

    The aim of this systematic review was to estimate the efficiency of hypnosis prior to medical procedures. Different databases were analyzed to identify randomized controlled trials (RCTs) comparing hypnosis to control interventions. All RCTs had to report pain or anxiety. Eighteen RCTs with a total of 968 patients were included; study size was from 20 to 200 patients (14 RCTs ≤ 60 patients). Fourteen RCTs included 830 adults and 4 RCTs included 138 children. Twelve of 18 RCTs had major quality limitations related to unclear allocation concealments, provider's experience in hypnosis, patient's adherence to hypnotic procedures, and intention-to-treat design. This systematic review observed major methodological limitations in RCTs on hypnosis prior to medical procedures.

  7. Review of the IEEE Standard for Computerized Operating Procedure Systems

    SciTech Connect

    O'Hara, J.; Higgins, J.

    2010-02-26

    Increasingly nuclear power plant procedures, such as emergency operating procedures, are being presented in computer form with functionality to support operator use and management of the procedures. The U.S. Nuclear Regulatory Commission (NRC) currently has guidance for the review of computer-based procedures (CBPs); however, there remain CBP functions and human performance issues for which up-to-date guidance is lacking. The Institute of Electrical and Electronics Engineers (IEEE) has initiated a standard development effort to address the human factors engineering (HFE) aspects of CBP systems. When completed, it may provide guidance to supplement the NRC staff's review criteria. The purpose of our study was to evaluate the suitability of the IEEE Standard for use in the NRC's HFE safety reviews of CBP systems and to ensure that the guidance meets the NRC's standard for scientific and engineering rigor used in its own guidance development efforts. We established the following criteria with which to evaluate the Standard: (1) it should meet an existing need of NRC reviewers, (2) it should be based in sound HFE principles, (3) it should be thoroughly peer-reviewed, and (4) it should address CBP-related human performance issues identified in the literature. This report describes the methodology we used to evaluate each criterion. Our evaluation concluded that the Standard generally does meet these criteria, however several areas were identified for which additional clarifications are needed. Thus consideration of the Standard's use by the NRC is supported. The standard evaluation methodology developed in this study can be generally applied to the review of other HFE standards being considered for possible use or endorsement by the NRC.

  8. Neurosurgical procedures in patients with liver cirrhosis: A review

    PubMed Central

    Chen, Ching-Chang; Huang, Yin-Cheng; Yeh, Chun-Nan

    2015-01-01

    Liver cirrhosis, a devastating liver fibrosis caused by hepatitis/inflammation or tumors, is a major comorbid factor in known surgery fields, such as cardiovascular and abdominal surgeries. It is important to review possible comorbid results in neurosurgical procedures in cirrhotic patients. In the reviewed literature, Child-Pugh and model for end-stage liver disease scores are commonly used in the assessment of surgical risks for cirrhotic patients undergoing abdominal, cardiovascular or neurosurgical procedures. The major categories of neurosurgery are traumatic brain injury (TBI), spontaneous intracranial hemorrhage (SICH), brain tumors, and spinal instrumentation procedures. TBI was reported with surgical mortality as high as 34.5% and a complication rate of 87.2%. For SICH, mortality ranged from 22.7% to 47.0%, while complications were reported to be 43.2%. Less is discussed in brain tumor patients; still the postoperative hemorrhage rate approached 26.7%. In spinal fusion instrumentation procedures, the complication rate was as high as 41.0%. Preoperative assessment and correction could possibly decrease complications such as hemorrhage, wound infection and other cirrhosis-related complications (renal, pulmonary, ascites and encephalopathy). In this study, we reviewed the neurosurgical-related literature with regard to liver cirrhosis as a prognostic factor influencing neurosurgical outcomes. PMID:26413225

  9. Neurosurgical procedures in patients with liver cirrhosis: A review.

    PubMed

    Chen, Ching-Chang; Huang, Yin-Cheng; Yeh, Chun-Nan

    2015-09-28

    Liver cirrhosis, a devastating liver fibrosis caused by hepatitis/inflammation or tumors, is a major comorbid factor in known surgery fields, such as cardiovascular and abdominal surgeries. It is important to review possible comorbid results in neurosurgical procedures in cirrhotic patients. In the reviewed literature, Child-Pugh and model for end-stage liver disease scores are commonly used in the assessment of surgical risks for cirrhotic patients undergoing abdominal, cardiovascular or neurosurgical procedures. The major categories of neurosurgery are traumatic brain injury (TBI), spontaneous intracranial hemorrhage (SICH), brain tumors, and spinal instrumentation procedures. TBI was reported with surgical mortality as high as 34.5% and a complication rate of 87.2%. For SICH, mortality ranged from 22.7% to 47.0%, while complications were reported to be 43.2%. Less is discussed in brain tumor patients; still the postoperative hemorrhage rate approached 26.7%. In spinal fusion instrumentation procedures, the complication rate was as high as 41.0%. Preoperative assessment and correction could possibly decrease complications such as hemorrhage, wound infection and other cirrhosis-related complications (renal, pulmonary, ascites and encephalopathy). In this study, we reviewed the neurosurgical-related literature with regard to liver cirrhosis as a prognostic factor influencing neurosurgical outcomes.

  10. 30 CFR 100.6 - Procedures for review of citations and orders; procedures for assessment of civil penalties and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; procedures for assessment of civil penalties and conferences. 100.6 Section 100.6 Mineral Resources MINE... SAFETY AND HEALTH ACT OF 1977 CRITERIA AND PROCEDURES FOR PROPOSED ASSESSMENT OF CIVIL PENALTIES § 100.6 Procedures for review of citations and orders; procedures for assessment of civil penalties and conferences...

  11. [Sensitivity study of a revised leaf photochemical reflectance index (PRI)].

    PubMed

    Wu, Chao-yang; Niu, Zheng; Tang, Quan

    2008-09-01

    Photochemical reflectance index (PRI) defined as a normalized difference index using two narrow reflectance bands at 531 and 570 nm that are closely related to xanthophyll cycle pigment content has been successfully used to estimate leaf photosynthetic light use efficiency (LUE) across species which vary in water content and nitrogen concentration. Previous research demonstrated that a consistent relationship could be established between PRI and LUE calculated from gas exchange measurements at the leaf, small canopy, and full forest or crop canopy scales. However, a number of problems, such as the saturation of PRI when LUE exceeds 0.03 mol CO2 mol(-1) PPED (photosynthetic photon flux density) and disjunctive relationships of PRI and LUE in seasonal changes, still existed and need to be handled in order to evaluate LUE more accurately. A sensitivity study of a revised PRI with four leaf parameters was performed based on PROSPECT model in the present article to study the effects of different biochemical concentrations on leaf SR-PRI (simple ratio PRI). Sensitivity study proved that leaf SR-PRI is more sensitive to leaf mesophyll structure parameter (N) and chlorophyll a + b content (c(ab)) than parameters of dry matter content (c(m)) and equivalent water thickness (c(w)), indicating that leaf mesophyll structure parameter (N) and chlorophyll a + b content (c(ab)) should be especially considered when acquiring leaf SR-PRI. And changes in the two parameters would cause large variation in SR-PRI which would reduce the precision for estimating light use efficiency. Validation study of SR-PRI was carried out in the analysis and the results proved that SR-PRI can also be a feasible index of estimating LUE for four species of plants with correlation coefficients better than that of PRI and LUE. The advantage of SR-PRI compared to PRI is its much clearer physical meaning and its sensitivity to the changes in reflectance at 531 nm which serves as a core parameter to evaluate

  12. [Ultrasound guided radial artery cannulation: procedure description and literature review].

    PubMed

    Carmona Monge, F J; Martínez Lareo, M; Núñez Reiz, A

    2011-01-01

    Arterial catheterization is the second most common invasive procedure performed in critical care units. These devices are essential in certain types of patients (the hemodinamically unstable or those who require regular evaluation of the gasometric values). Complications related to arterial cannulation are relatively scarce. However, there are no reliable indicators to predict the occurrence of radial artery occlusions or ischemic lesions in the hand after a radial cannulation procedure has been performed. Ultrasound-guided catheter insertion has been used for years to guide central venous cannulation in critical care, but its use has been more limited for arterial catheterization. This paper aims to describe the technique of ultrasound-guided radial artery catheterization and reviews the most important research papers that have evaluated the safety and efficacy of this procedure in the adult population.

  13. Observation procedures characterizing occupational physical activities: critical review.

    PubMed

    Denis, D; Lortie, M; Rossignol, M

    2000-01-01

    The first objective of this paper is to compare the observation procedures proposed to characterize physical work. The second objective is to examine the following 3 methodological issues: reliability, observer training, and internal validity. Seventy-two papers were reviewed, 38 of which proposed a new or modified observation grid. The observation variables identified were broken down into 7 categories as follows: posture, exertion, load handled, work environment, use of feet, use of hands, and activities or tasks performed. The review revealed the variability of existing procedures. The examination of methodological issues showed that observation data can be reliable and can present an adequate internal validity. However, little information about the conditions necessary to achieve good reliability was available.

  14. A double-blind, clinical evaluation of facial augmentation treatments: a comparison of PRI 1, PRI 2, Zyplast and Perlane.

    PubMed

    Downie, Jeff; Mao, Zhili; Rachel Lo, Tsz-Wai; Barry, Sarah; Bock, Mitchum; Siebert, J Paul; Bowman, Adrian; Ayoub, Ashraf

    2009-12-01

    Facial wrinkles are caused by weakening of the sub-dermal collagen support layer. Dermal fillers can be used to treat wrinkles, and this double-blind, randomised, single-centre study compared four fillers: PRI 1, PRI 2 (both porcine collagen), Zyplast (purified bovine collagen) and Perlane (cross-linked hyaluronic acid gel). 79 females (aged 25-55 years) with wrinkles in the upper lip line border were randomised to PRI 1 (19 patients), PRI 2 (19 patients), Perlane (23 patients), Zyplast (18 patients). Patients were assessed at 1 week and 1, 3, 6, 9 and 12 months using 2D images and by mathematically derived facial volume changes using 3D stereophotogrammetry. All treatments produced larger, less wrinkled, more prominent lips. PRI 1, PRI 2 and Zyplast showed similar lip volume gains, with Perlane showing the greatest upper lip volume increase. All treatments were comparable for rates of decrease in upper lip volume post-treatment, however, Perlane maintained higher lip volume gains at each time point. Investigators indicated PRI 1 was significantly easier to deliver than Zyplast. Patient satisfaction scores were similar, though there was a trend towards greater dissatisfaction for PRI 1 and PRI 2 at month 9 (p=0.052). Treatment was well-tolerated, with 'cold sore' being the most common adverse event. Results showed that PRI 1 and PRI 2 were comparable to Perlane and Zyplast as dermal fillers. Further rigorous studies are required to establish the performance of dermal fillers and patient acceptability. We propose the utilisation of stereophotogrammetry for assessment of volume changes.

  15. Investigating the Role of Helicobacter pylori PriA Protein.

    PubMed

    Singh, Aparna; Blaskovic, Dusan; Joo, Jungsoo; Yang, Zhen; Jackson, Sharon H; Coleman, William G; Yan, Ming

    2016-08-01

    In bacteria, PriA protein, a conserved DEXH-type DNA helicase, plays a central role in replication restart at stalled replication forks. Its unique DNA binding property allows it to recognize and stabilize stalled forks and the structures derived from them. PriA plays a very critical role in replication fork stabilization and DNA repair in E. coli and N. gonorrhoeae. In our in vivo expression technology screen, priA gene was induced in vivo when Helicobacter pylori infects mouse stomach. We decided to elucidate the role of H. pylori PriA protein in survival in mouse stomach, survival in gastric epithelial cells and macrophage cells, DNA repair, acid stress, and oxidative stress. The priA null mutant strain was unable to colonize mice stomach mucosa after long-term infections. Mouse colonization was observed after 1 week of infection, but the levels were much lower than the wild-type HpSS1 strain. PriA protein was found to be important for intracellular survival of epithelial cell-/macrophage cell-ingested H. pylori. Also, a priA null mutant was more sensitive to DNA-damaging agents and was much more sensitive to acid and oxidative stress as compared to the wild-type strain. These data suggest that the PriA protein is needed for survival and persistence of H. pylori in mice stomach mucosa. © 2016 John Wiley & Sons Ltd.

  16. Token Economy: A Systematic Review of Procedural Descriptions.

    PubMed

    Ivy, Jonathan W; Meindl, James N; Overley, Eric; Robson, Kristen M

    2017-09-01

    The token economy is a well-established and widely used behavioral intervention. A token economy is comprised of six procedural components: the target response(s), a token that functions as a conditioned reinforcer, backup reinforcers, and three interconnected schedules of reinforcement. Despite decades of applied research, the extent to which the procedures of a token economy are described in complete and replicable detail has not been evaluated. Given the inherent complexity of a token economy, an analysis of the procedural descriptions may benefit future token economy research and practice. Articles published between 2000 and 2015 that included implementation of a token economy within an applied setting were identified and reviewed with a focus on evaluating the thoroughness of procedural descriptions. The results show that token economy components are regularly omitted or described in vague terms. Of the articles included in this analysis, only 19% (18 of 96 articles reviewed) included replicable and complete descriptions of all primary components. Missing or vague component descriptions could negatively affect future research or applied practice. Recommendations are provided to improve component descriptions.

  17. Effectiveness of granite cleaning procedures in cultural heritage: A review.

    PubMed

    Pozo-Antonio, J S; Rivas, T; López, A J; Fiorucci, M P; Ramil, A

    2016-11-15

    Most of the Cultural Heritage built in NW Iberian Peninsula is made of granite which exposition to the environment leads to the formation of deposits and coatings, mainly two types: biological colonization and sulphated black crusts. Nowadays, another form of alteration derives from graffiti paints when these are applied as an act of vandalism. A deep revision needs to be addressed considering the severity of these deterioration forms on granite and the different cleaning effectiveness achieved by cleaning procedures used to remove them. The scientific literature about these topics on granite is scarcer than on sedimentary carbonate stones and marbles, but the importance of the granite in NW Iberian Peninsula Cultural Heritage claims this review centred on biological colonization, sulphated black crusts and graffiti on granite and their effectiveness of the common cleaning procedures. Furthermore, this paper carried out a review of the knowledge about those three alteration forms on granite, as well as bringing together all the major studies in the field of the granite cleaning with traditional procedures (chemical and mechanical) and with the recent developed technique based on the laser ablation. Findings concerning the effectiveness evaluation of these cleaning procedures, considering the coating extraction ability and the damage induced on the granite surface, are described. Finally, some futures research lines are pointed out.

  18. Review of advanced catheter technologies in radiation oncology brachytherapy procedures

    PubMed Central

    Zhou, Jun; Zamdborg, Leonid; Sebastian, Evelyn

    2015-01-01

    The development of new catheter and applicator technologies in recent years has significantly improved treatment accuracy, efficiency, and outcomes in brachytherapy. In this paper, we review these advances, focusing on the performance of catheter imaging and reconstruction techniques in brachytherapy procedures using magnetic resonance images and electromagnetic tracking. The accuracy of catheter reconstruction, imaging artifacts, and other notable properties of plastic and titanium applicators in gynecologic treatments are reviewed. The accuracy, noise performance, and limitations of electromagnetic tracking for catheter reconstruction are discussed. Several newly developed applicators for accelerated partial breast irradiation and gynecologic treatments are also reviewed. New hypofractionated high dose rate treatment schemes in prostate cancer and accelerated partial breast irradiation are presented. PMID:26203277

  19. Review of advanced catheter technologies in radiation oncology brachytherapy procedures.

    PubMed

    Zhou, Jun; Zamdborg, Leonid; Sebastian, Evelyn

    2015-01-01

    The development of new catheter and applicator technologies in recent years has significantly improved treatment accuracy, efficiency, and outcomes in brachytherapy. In this paper, we review these advances, focusing on the performance of catheter imaging and reconstruction techniques in brachytherapy procedures using magnetic resonance images and electromagnetic tracking. The accuracy of catheter reconstruction, imaging artifacts, and other notable properties of plastic and titanium applicators in gynecologic treatments are reviewed. The accuracy, noise performance, and limitations of electromagnetic tracking for catheter reconstruction are discussed. Several newly developed applicators for accelerated partial breast irradiation and gynecologic treatments are also reviewed. New hypofractionated high dose rate treatment schemes in prostate cancer and accelerated partial breast irradiation are presented.

  20. Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells.

    PubMed

    Milczarek, Magdalena; Chodyński, Michał; Filip-Psurska, Beata; Martowicz, Agnieszka; Krupa, Małgorzata; Krajewski, Krzysztof; Kutner, Andrzej; Wietrzyk, Joanna

    2013-10-31

    Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) and tacalcitol (PRI-2191) were used as the reference compounds. Among a series of tested analogs the diastereomeric analog PRI-2202 showed the strongest antiproliferative activity on the human breast cancer cell line MCF-7, whereas the geometric analog PRI-2205 was the weakest. Both analogs were less potent in antiproliferative activity against HL-60 cells compared to the reference compounds. The ability to potentiate antiproliferative effect of cisplatin or doxorubicin against HL-60 cells or that of tamoxifen against the MCF-7 cell line was observed at higher doses of PRI-2202 or PRI-2205 than those of the reference compounds. The proapoptotic activity of tamoxifen, expressed as the diminished mitochondrial membrane potential, as well as the increased phosphatidylserine expression, was partially attenuated by calcitriol, PRI-2191, PRI-2201 and PRI-2205. The treatment of the MCF-7 cells with tamoxifen alone resulted in an increase in VDR expression. Moreover, a further increase in VDR expression was observed when the analogs PRI-2201 or PRI-2205, but not PRI-2191, were used in combination with tamoxifen. This observation could partially explain the potentiation of the antiproliferative effect of tamoxifen by vitamin D analogs.

  1. Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells

    PubMed Central

    Milczarek, Magdalena; Chodyński, Michał; Filip-Psurska, Beata; Martowicz, Agnieszka; Krupa, Małgorzata; Krajewski, Krzysztof; Kutner, Andrzej; Wietrzyk, Joanna

    2013-01-01

    Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) and tacalcitol (PRI-2191) were used as the reference compounds. Among a series of tested analogs the diastereomeric analog PRI-2202 showed the strongest antiproliferative activity on the human breast cancer cell line MCF-7, whereas the geometric analog PRI-2205 was the weakest. Both analogs were less potent in antiproliferative activity against HL-60 cells compared to the reference compounds. The ability to potentiate antiproliferative effect of cisplatin or doxorubicin against HL-60 cells or that of tamoxifen against the MCF-7 cell line was observed at higher doses of PRI-2202 or PRI-2205 than those of the reference compounds. The proapoptotic activity of tamoxifen, expressed as the diminished mitochondrial membrane potential, as well as the increased phosphatidylserine expression, was partially attenuated by calcitriol, PRI-2191, PRI-2201 and PRI-2205. The treatment of the MCF-7 cells with tamoxifen alone resulted in an increase in VDR expression. Moreover, a further increase in VDR expression was observed when the analogs PRI-2201 or PRI-2205, but not PRI-2191, were used in combination with tamoxifen. This observation could partially explain the potentiation of the antiproliferative effect of tamoxifen by vitamin D analogs. PMID:24202449

  2. Graft-Free Sinus Augmentation Procedure: a Literature Review

    PubMed Central

    Juodzbalys, Gintaras

    2014-01-01

    ABSTRACT Objectives The restoration of edentulous posterior maxilla with dental implants is challenging due to a deficient posterior alveolar ridge. Over the last decade an advance in the graftless bone augmentation procedures had occurred where the space left beneath the Schneiderian membrane is filled with blood clot in order to produce bone formation. The aim of present article is to review the scientific literature with respect to bone formation in the sinus, after membrane elevation procedure, without using any bone substitutes. Material and Methods A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The articles were searched from 1993 to 2013. English language articles with minimum one year patient follow-up and radiological and/or histological diagnostics of newly formed bone were included. Articles were excluded, if usage of bone graft or bone substitutes and/or usage of osteotome has been made during sinus lift operation. Results A total of 19 studies were included: 2 studies were related to the sinus membrane’s osteogenic potential, 3 to the histological evidence of bone formation in monkeys and humans, 12 to the radiologic evidence of bone gain, and 2 to the space-maintaining management. 100% of the reviewed articles presented with increased bone formation and high implant survival rates resulting from the graft-free technique. Conclusions It is clearly shown in the review that the potential of the maxillary sinus to heal and to form new bone without bone grafts or substitutes is of high nature. PMID:24800051

  3. Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins.

    PubMed

    Coelho, Miguel B; Ascher, David B; Gooding, Clare; Lang, Emma; Maude, Hannah; Turner, David; Llorian, Miriam; Pires, Douglas E V; Attig, Jan; Smith, Christopher W J

    2016-08-15

    Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands. © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.

  4. TOPICAL REVIEW: Image-guidance for surgical procedures

    NASA Astrophysics Data System (ADS)

    Peters, Terry M.

    2006-07-01

    Contemporary imaging modalities can now provide the surgeon with high quality three- and four-dimensional images depicting not only normal anatomy and pathology, but also vascularity and function. A key component of image-guided surgery (IGS) is the ability to register multi-modal pre-operative images to each other and to the patient. The other important component of IGS is the ability to track instruments in real time during the procedure and to display them as part of a realistic model of the operative volume. Stereoscopic, virtual- and augmented-reality techniques have been implemented to enhance the visualization and guidance process. For the most part, IGS relies on the assumption that the pre-operatively acquired images used to guide the surgery accurately represent the morphology of the tissue during the procedure. This assumption may not necessarily be valid, and so intra-operative real-time imaging using interventional MRI, ultrasound, video and electrophysiological recordings are often employed to ameliorate this situation. Although IGS is now in extensive routine clinical use in neurosurgery and is gaining ground in other surgical disciplines, there remain many drawbacks that must be overcome before it can be employed in more general minimally-invasive procedures. This review overviews the roots of IGS in neurosurgery, provides examples of its use outside the brain, discusses the infrastructure required for successful implementation of IGS approaches and outlines the challenges that must be overcome for IGS to advance further.

  5. A review of human drug self-administration procedures

    PubMed Central

    Jones, Jermaine D.; Comer, Sandra D.

    2014-01-01

    Drug self-administration procedures in laboratory settings allow us to closely model drug-taking behavior in real-world settings. This review provides an overview of many of the common self-administration methods used in human laboratory research. Typically, self-administration studies provide a quantifiable measure of the reinforcing effect of a drug, which is believed to be predictive of its potential for abuse. Several adaptations of the self-administration paradigm exist, the simplest of which allows participants free access to the drug under investigation. Free-access procedures allow investigators to observe patterns of drug self-administration and drug effects in a controlled setting. Allowing participants to choose between two simultaneously available reinforcers (choice procedures) is another well-established method of assessing the reinforcing effects of a drug. Offering a choice between two reinforcers (e.g. two different doses of the same drug, two different drugs, or drug and nondrug reinforcers) provides researchers with a point of comparison (e.g. between a drug of known abuse potential and a novel drug). When combined with other endpoints, such as subjective effects ratings, physiological responses, and cognitive performance, human self-administration paradigms have contributed significantly to our understanding of the factors that contribute to, maintain, and alter drug-taking behavior including: craving, positive subjective effects, toxicity, drug interactions and abstinence. This area of research has also begun to incorporate other techniques such as imaging and genetics to further understand the multifaceted nature of substance abuse. The present paper summarizes the different self-administration techniques that are commonly used today and the application of other procedures that may complement interpretation of the drug PMID:23839027

  6. Explaining the variability of Photochemical Reflectance Index (PRI): deconvolution of variability related to Light Use Efficiency and Canopy attributes.

    NASA Astrophysics Data System (ADS)

    Merlier, Elodie; Hmimina, Gabriel; Dufrêne, Eric; Soudani, Kamel

    2014-05-01

    . 1992. A narrow-waveband spectral index that tracks diurnal changes in photosynthetic efficiency. Remote Sensing of Environment 41, 35-44. Garbulsky MF, Peñuelas J, Gamon J, Inoue Y, Filella I. 2011. The photochemical reflectance index (PRI) and the remote sensing of leaf, canopy and ecosystem radiation use efficiencies: A review and meta-analysis. Remote Sensing of Environment 115, 281-297. Hilker T, Coops NC, Hall FG, Black TA, Wulder MA, Nesic Z, Krishnan P. 2008. Separating physiologically and directionally induced changes in PRI using BRDF models. Remote Sensing of Environment 112, 2777-2788. Hmimina G, Dufrêne E, Soudani K. 2014. Relationship between PRI and leaf ecophysiological and biochemical parameters under two different water statuses: toward a rapid and efficient correction method using real-time measurements. Plant, Cell & Environment 37, 2, 473-487. Nakaji T, Oguma H, Fujinuma Y. 2006. Seasonal changes in the relationship between photochemical reflectance index and photosynthetic light use efficiency of Japanese larch needles. International Journal of Remote Sensing 27, 493-509. Rahimzadeh-Bajgiran P, Munehiro M, Omasa K. 2012. Relationships between the photochemical reflectance index (PRI) and chlorophyll fluorescence parameters and plant pigment indices at different leaf growth stages. Photosynthesis Research 113, 261-271.

  7. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  8. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  9. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  10. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  11. 5 CFR 1201.114 - Petition and cross petition for review-content and procedure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-content and procedure. 1201.114 Section 1201.114 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES AND PROCEDURES Petitions for Review of Initial Decisions § 1201.114... for review is a pleading in which a party contends that an initial decision was incorrectly decided in...

  12. 5 CFR 1201.117 - Board decisions; procedures for review or reopening.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Board decisions; procedures for review or reopening. 1201.117 Section 1201.117 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES AND PROCEDURES Petitions for Review of Initial Decisions § 1201.117...

  13. 20 CFR 404.976 - Procedures before Appeals Council on review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Procedures before Appeals Council on review. 404.976 Section 404.976 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS... Determinations and Decisions Appeals Council Review § 404.976 Procedures before Appeals Council on review....

  14. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  15. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  16. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  17. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  18. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  19. Finding the SurPriSe: A Case Study of a Faculty Learning Community

    ERIC Educational Resources Information Center

    Michel, Roberta M.

    2014-01-01

    This article details a faculty learning community (FLC) that started in 2009 on the campus of a Midwestern University and has evolved into an interdisciplinary research, teaching and social community of practice and learning called SurPriSe. SurPriSe is an acronym that reflects the interest area of the FLC; Sur for surveillance, Pri for privacy,…

  20. DOE EERE Standard Operating Procedure Peer Review Best Practice and Procedures

    SciTech Connect

    2009-01-18

    Objective review and advice from peers - peer review - provides managers, staff, and researchers with a powerful and effective tool for enhancing the management, relevance, effectiveness, and productivity of all of the EERE research, development

  1. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... determinations and fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track...

  2. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track appeals...

  3. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track appeals...

  4. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... determinations and fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track...

  5. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... determinations and fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track...

  6. Ethical review: Standardizing procedures and local shaping of ethical review practices.

    PubMed

    Jaspers, Patricia; Houtepen, Rob; Horstman, Klasien

    2013-12-01

    Since ethical review practice has developed in relation to specific regulatory regimes and local contexts, it cannot be understood without paying attention to the institutional context of ethical review practices. We believe the tendency towards strong central governance and standardization in ethical review implies a lack of understanding of how specific local institutional contexts actually affect ethical review practices. Our question is: "How do local institutional contexts relate to the way REC's shape their formal mandate, and what are the implications for research governance?" To get in-depth insights in how REC's shape their formal mandates in every-day practice, we did a qualitative ethnographic-sociological study of three Dutch REC's in different contexts: an academic context, a care context and a commercial context. In analyzing these three REC's we paid attention to the procedures operative in REC practices, the cultures and everyday experiences of REC members, the scientific, social and financial resources that are available to REC's, and the evaluative perspective REC's employ. We conclude that specific local, institutional contexts offer valuable resources for ethical review. To track this, insight into the institutional configuration as a whole is necessary. Variations in the ways REC's shape their formal mandate should not be regarded problematic, but rather as fruitful opportunities for public learning.

  7. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., “Application for Review of Discharge or Separation from the Armed Forces of the United States,” with such other..., The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within 15... (including decisions maintained by the Armed Forces Discharge Review Board/Corrective Board Reading...

  8. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., “Application for Review of Discharge or Separation from the Armed Forces of the United States,” with such other..., The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within 15... (including decisions maintained by the Armed Forces Discharge Review Board/Corrective Board Reading...

  9. Constant and Progressive Time Delay Procedures for Teaching Children with Autism: A Literature Review

    ERIC Educational Resources Information Center

    Walker, Gabriela

    2008-01-01

    A review of 22 empirical studies examining the use of constant (CTD) and progressive (PTD) time delay procedures employed with children with autism frames an indirect analysis of the demographic, procedural, methodological, and outcome parameters of existing research. None of the previous manuscripts compared the two response prompting procedures.…

  10. 7 CFR 658.7 - USDA assistance with Federal agencies' reviews of policies and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... or suggests changes in laws, administrative rules and regulations, policies, or procedures that may... policies and procedures. 658.7 Section 658.7 Agriculture Regulations of the Department of Agriculture... PROTECTION POLICY ACT § 658.7 USDA assistance with Federal agencies' reviews of policies and procedures. (a...

  11. 7 CFR 658.7 - USDA assistance with Federal agencies' reviews of policies and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... or suggests changes in laws, administrative rules and regulations, policies, or procedures that may... policies and procedures. 658.7 Section 658.7 Agriculture Regulations of the Department of Agriculture... PROTECTION POLICY ACT § 658.7 USDA assistance with Federal agencies' reviews of policies and procedures. (a...

  12. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of Base...

  13. 78 FR 49280 - 60-Day Notice of Proposed Information Collection: Environmental Review Procedures for Entities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... environmental laws, executive orders, and authorities, and Part 58 procedure. When the environmental review... certify their compliance with all applicable environmental laws and authorities. HUD (or the State for... URBAN DEVELOPMENT 60-Day Notice of Proposed Information Collection: Environmental Review Procedures...

  14. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Accreditation Body § 8.28 Expedited procedures for review of immediate suspension. (a) Applicability. When the...

  15. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Accreditation Body § 8.28 Expedited procedures for review of immediate suspension. (a) Applicability. When the...

  16. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Accreditation Body § 8.28 Expedited procedures for review of immediate suspension. (a) Applicability. When the...

  17. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Accreditation Body § 8.28 Expedited procedures for review of immediate suspension. (a) Applicability. When...

  18. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Accreditation Body § 8.28 Expedited procedures for review of immediate suspension. (a) Applicability. When...

  19. 75 FR 29321 - Streamlined Procedure for Appeal Brief Review in Ex Parte Reexamination Proceedings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... Patent and Trademark Office Streamlined Procedure for Appeal Brief Review in Ex Parte Reexamination... States Patent and Trademark Office (USPTO) is streamlining the procedure for the review of appeal briefs... whether appeal briefs filed in ex parte reexamination proceeding appeals comply with the applicable...

  20. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  1. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  2. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  3. PRiME: integrating professional responsibility into the engineering curriculum.

    PubMed

    Moore, Christy; Hart, Hillary; Randall, D'Arcy; Nichols, Steven P

    2006-04-01

    Engineering educators have long discussed the need to teach professional responsibility and the social context of engineering without adding to overcrowded curricula. One difficulty we face is the lack of appropriate teaching materials that can fit into existing courses. The PRiME (Professional Responsibility Modules for Engineering) Project (http://www.engr.utexas.edu/ethics/primeModules.cfm) described in this paper was initiated at the University of Texas, Austin to provide web-based modules that could be integrated into any undergraduate engineering class. Using HPL (How People Learn) theory, PRiME developed and piloted four modules during the academic year 2004-2005. This article introduces the modules and the pilot, outlines the assessment process, analyzes the results, and describes how the modules are being revised in light of the initial assessment. In its first year of development and testing, PRiME made significant progress towards meeting its objectives. The PRiME Project can strengthen engineering education by providing faculty with an effective system for engaging students in learning about professional responsibility.

  4. A review of nonstandardized applicators digitization in Nucletron™ HDR procedures.

    PubMed

    Wang, Kelin; Ferenci, Michele S; de la Zerda, Alberto; Padgett, Kyle R; Bossart, Elizabeth L; Chao, Ming; Shao, Hua; Zhang, Mutain

    2017-09-01

    The major errors in HDR procedures were failures to enter the correct treatment distance, which could be caused by either entering wrong transmission lengths or imprecisely digitizing the dwelling positions. Most of those errors were not easily avoidable by enhancing the HDR management level because they were caused by implementations of nonstandardized applicators utilizing transmission tubes of different lengths in standard HDR procedures. We performed this comprehensive study to include all possible situations with different nonstandardized applicators that frequently occurred in HDR procedures, provide corresponding situations with standard applicator as comparisons, list all possible errors and in planning, clarify the confusions in offsets setting, and provide mathematical and quantitative solutions for each given scenarios. Training on HDR procedures with nonstandardized applicators are normally not included in most residential program for medical physics, thus this study could be meaningful in both clinical and educational purpose. At precision of 1 mm, our study could be used as the essential and practical reference for finding the correct treatment length as well as locating the accurate dwelling positions in any HDR procedure with nonstandardized applicators. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

  5. HYPNOSIS FOR ACUTE PROCEDURAL PAIN: A Critical Review

    PubMed Central

    Kendrick, Cassie; Sliwinski, Jim; Yu, Yimin; Johnson, Aimee; Fisher, William; Kekecs, Zoltán; Elkins, Gary

    2015-01-01

    Clinical evidence for the effectiveness of hypnosis in the treatment of acute, procedural pain was critically evaluated based on reports from randomized controlled clinical trials (RCTs). Results from the 29 RCTs meeting inclusion criteria suggest that hypnosis decreases pain compared to standard care and attention control groups and that it is at least as effective as comparable adjunct psychological or behavioral therapies. In addition, applying hypnosis in multiple sessions prior to the day of the procedure produced the highest percentage of significant results. Hypnosis was most effective in minor surgical procedures. However, interpretations are limited by considerable risk of bias. Further studies using minimally effective control conditions and systematic control of intervention dose and timing are required to strengthen conclusions. PMID:26599994

  6. Hypnosis for Acute Procedural Pain: A Critical Review.

    PubMed

    Kendrick, Cassie; Sliwinski, Jim; Yu, Yimin; Johnson, Aimee; Fisher, William; Kekecs, Zoltán; Elkins, Gary

    2016-01-01

    Clinical evidence for the effectiveness of hypnosis in the treatment of acute procedural pain was critically evaluated based on reports from randomized controlled clinical trials (RCTs). Results from the 29 RCTs meeting inclusion criteria suggest that hypnosis decreases pain compared to standard care and attention control groups and that it is at least as effective as comparable adjunct psychological or behavioral therapies. In addition, applying hypnosis in multiple sessions prior to the day of the procedure produced the highest percentage of significant results. Hypnosis was most effective in minor surgical procedures. However, interpretations are limited by considerable risk of bias. Further studies using minimally effective control conditions and systematic control of intervention dose and timing are required to strengthen conclusions.

  7. Procedural justice and layoff survivors' commitment: a quantitative review.

    PubMed

    Grubb, W Lee

    2006-10-01

    Layoffs are common in today's organizations. Most studies that have examined the correlation between procedural justice and the organizational commitment of layoff survivors have yielded positive correlations, but the magnitude of the correlations varies widely. This study is the first to estimate the population correlation and to identify the primary sources that cause variation in the correlation across studies. The results indicated that justice and commitment correlations can always be expected to be positive. Based on a total sample size of 9080 individuals, the estimated mean population correlation was .34. Variation was primarily explained by attributes of the justice measure where multiple items scales and scales composed of both interactional and procedural justice items yielded higher correlations than single item measures. Therefore, it is important that employers recognize the substantial assuaging affect that procedural and interactional justice can have on survivors' organizational commitment.

  8. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... Administration, or by writing to: DA Military Review Boards Agency, Attention: SFBA (Reading Room), Room 1E520, The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within...

  9. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... Administration, or by writing to: DA Military Review Boards Agency, Attention: SFBA (Reading Room), Room 1E520, The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within...

  10. Transcatheter Renal Interventions: A Review of Established and Emerging Procedures

    PubMed Central

    Minocha, Jeet; Parvinian, Ahmad; Bui, James T; Knuttinen, Martha Grace; Ray, Charles E; Gaba, Ron C

    2015-01-01

    Catheter-based interventions play an important role in the multidisciplinary management of renal pathology. The array of procedures available to interventional radiologists (IRs) includes established techniques such as angioplasty, stenting, embolization, thrombolysis, and thrombectomy for treatment of renovascular disease, as well as embolization of renal neoplasms and emerging therapies such as transcatheter renal artery sympathectomy for treatment of resistant hypertension. Here, we present an overview of these minimally invasive therapies, with an emphasis on interventional technique and clinical outcomes of the procedure. PMID:25806140

  11. Development of electrical test procedures for qualification of spacecraft against EID. Volume 2: Review and specification of test procedures

    NASA Technical Reports Server (NTRS)

    Wilkenfeld, J. M.; Harlacher, B. L.; Mathews, D.

    1982-01-01

    A combined experimental and analytical program to develop system electrical test procedures for the qualification of spacecraft against damage produced by space-electron-induced discharges (EID) occurring on spacecraft dielectric outer surfaces is described. A review and critical evaluation of possible approaches to qualify spacecraft against space electron-induced discharges (EID) is presented. A variety of possible schemes to simulate EID electromagnetic effects produced in spacecraft was studied. These techniques form the principal element of a provisional, recommended set of test procedures for the EID qualification spacecraft. Significant gaps in our knowledge about EID which impact the final specification of an electrical test to qualify spacecraft against EID are also identified.

  12. 15 CFR 960.6 - Review procedures for license applications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... those procedures, including time lines, described in the Fact Sheet, at Appendix 2 of this part, which..., within three (3) working days of receipt of an application, forward a copy of the application to the Department of Defense, the Department of State, the Department of the Interior, and any other Federal...

  13. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES GENERAL § 1355.33 Procedures for...

  14. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES GENERAL § 1355.33 Procedures for...

  15. Applications of Self-Control Procedures by Children: A Review.

    ERIC Educational Resources Information Center

    O'Leary, Susan G.; Dubey, Dennis R.

    1979-01-01

    Particular emphasis is on self-instruction, self-determined criteria, self-assessment, and self-reinforcement. Self-punishment, comprehensive programs, and innovative self-control procedures (including distraction and restatement of contingencies) are also evaluated. (Author/DLS)

  16. Applications of Self-Control Procedures by Children: A Review.

    ERIC Educational Resources Information Center

    O'Leary, Susan G.; Dubey, Dennis R.

    1979-01-01

    Particular emphasis is on self-instruction, self-determined criteria, self-assessment, and self-reinforcement. Self-punishment, comprehensive programs, and innovative self-control procedures (including distraction and restatement of contingencies) are also evaluated. (Author/DLS)

  17. Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model.

    PubMed

    Wietrzyk, Joanna; Nevozhay, Dmitry; Milczarek, Magdalena; Filip, Beata; Kutner, Andrzej

    2008-10-01

    Active and less toxic vitamin D analogs could be useful for clinical applications. In the present study, we evaluated the toxicity and antitumor effect of two new synthetic analogs of vitamin D, namely PRI-1906 [(24E)-24a-Homo-(1S)-1,25-dihydroxyergocalciferol] and its side-chain unsaturated homo analog PRI-1907. The toxicity and calcemic activity, as well as antitumor effect of calcitriol analogs was investigated in vivo. The studies were performed in a mouse mammary 16/C cancer model. Since calcitriol and its analogs inhibited 16/C tumor growth only slightly, we applied them in the combined therapy with cyclophosphamide (CY). Moreover, cell cycle analysis and VDR and p27 expression were investigated. The LD50 values after five daily subcutaneous (s.c.) injections were 7.8, 10.0 and 2.4 microg/kg per day for calcitriol, PRI-1906 and PRI-1907, respectively. The serum calcium level increased to 40, 23 and 63% over the control for these compounds. We also compare the antitumor activity of the PRI-1906 with the calcitriol and previously studied PRI-2191 (1,24-dihydroxyvitamin D3, tacalcitol). Statistically significant inhibition of tumor growth by calcitriol up to the eighth day was observed in all schedules applied. PRI-1906 inhibited the tumor growth at doses 1 and 5 microg/kg per day, and PRI-2191 only at the dose 5 microg/kg per day. Addition of vitamin D analogs increased the antitumor effect of CY. PRI-1906 exhibited toxicity higher than PRI-2191 but lower than calcitriol and antitumor activity similar to both PRI-2191 and calcitriol. This new analog seems to be a good candidate for the combined treatment of mammary cancer.

  18. NAFTA Revised Procedures for Joint Review of Microbials and Semiochemicals

    EPA Pesticide Factsheets

    The Canadian Pest Management Regulatory Agency and EPA have established a process for the joint review of pest control products in which the new active ingredient is a microbial or an arthropod semiochemical (including pheromones).

  19. Measuring procedures to determine the Cobb angle in idiopathic scoliosis: a systematic review.

    PubMed

    Langensiepen, S; Semler, O; Sobottke, R; Fricke, O; Franklin, J; Schönau, E; Eysel, P

    2013-11-01

    Scoliosis of the vertebral column can be assessed with the Cobb angle (Cobb 1948). This examination is performed manually by measuring the angle on radiographs and is considered the gold standard. However, studies evaluating the reproducibility of this procedure have shown high variability in intra- and inter-observer agreement. Because of technical advancements, interests in new procedures to determine the Cobb angle has been renewed. This review aims to systematically investigate the reproducibility of various new techniques to determine the Cobb angle in idiopathic scoliosis and to assess whether new technical procedures are reasonable alternatives when compared to manual measurement of the Cobb angle. Systematic review. Studies examining procedures used to determine the Cobb angle were selected. Two review authors independently selected studies for inclusion, extracted data and assessed risk of bias. Statistical results of reliability and agreement were summarised and described. Eleven studies of new measuring procedures were included, all reporting the reproducibility. The new procedures can be divided into computer-assisted procedures, automatic procedures and smartphone apps. All investigated measuring procedures showed high degrees of reliability. In general, digital procedures tend to be slightly better than manual ones. For all other measurement procedures (automatic or smartphone), results varied. Studies implementing vertebral pre-selection and observer training achieved better agreement.

  20. [Review As You Go: Oklahoma City Public Schools' Plan Using Saxon's Procedures.

    ERIC Educational Resources Information Center

    Hartzler, Stan

    This document consists of three related items. The first brief paper describes the components of a cumulative daily review program and its origins, rationale, and outcomes. The review-as-you-go (RAYG) format entails planning cumulative examinations and providing review problems each day. The procedure once was routinely used; today it is…

  1. [Review As You Go: Oklahoma City Public Schools' Plan Using Saxon's Procedures.

    ERIC Educational Resources Information Center

    Hartzler, Stan

    This document consists of three related items. The first brief paper describes the components of a cumulative daily review program and its origins, rationale, and outcomes. The review-as-you-go (RAYG) format entails planning cumulative examinations and providing review problems each day. The procedure once was routinely used; today it is…

  2. Procedural instruction in invasive bedside procedures: a systematic review and meta-analysis of effective teaching approaches.

    PubMed

    Huang, Grace C; McSparron, Jakob I; Balk, Ethan M; Richards, Jeremy B; Smith, C Christopher; Whelan, Julia S; Newman, Lori R; Smetana, Gerald W

    2016-04-01

    Optimal approaches to teaching bedside procedures are unknown. To identify effective instructional approaches in procedural training. We searched PubMed, EMBASE, Web of Science and Cochrane Library through December 2014. We included research articles that addressed procedural training among physicians or physician trainees for 12 bedside procedures. Two independent reviewers screened 9312 citations and identified 344 articles for full-text review. Two independent reviewers extracted data from full-text articles. We included measurements as classified by translational science outcomes T1 (testing settings), T2 (patient care practices) and T3 (patient/public health outcomes). Due to incomplete reporting, we post hoc classified study outcomes as 'negative' or 'positive' based on statistical significance. We performed meta-analyses of outcomes on the subset of studies sharing similar outcomes. We found 161 eligible studies (44 randomised controlled trials (RCTs), 34 non-RCTs and 83 uncontrolled trials). Simulation was the most frequently published educational mode (78%). Our post hoc classification showed that studies involving simulation, competency-based approaches and RCTs had higher frequencies of T2/T3 outcomes. Meta-analyses showed that simulation (risk ratio (RR) 1.54 vs 0.55 for studies with vs without simulation, p=0.013) and competency-based approaches (RR 3.17 vs 0.89, p<0.001) were effective forms of training. This systematic review of bedside procedural skills demonstrates that the current literature is heterogeneous and of varying quality and rigour. Evidence is strongest for the use of simulation and competency-based paradigms in teaching procedures, and these approaches should be the mainstay of programmes that train physicians to perform procedures. Further research should clarify differences among instructional methods (eg, forms of hands-on training) rather than among educational modes (eg, lecture vs simulation). Published by the BMJ Publishing

  3. The Veterinary Forensic Necropsy: A Review of Procedures and Protocols.

    PubMed

    Brownlie, H W Brooks; Munro, R

    2016-09-01

    Investigation of animal-related crime, and therefore submission of forensic cases to veterinary pathology facilities, is increasing, yet many veterinary pathologists are unfamiliar and often uncomfortable with involvement in the forensic necropsy. This article discusses various aspects of the forensic necropsy without specific attention to any particular species group or crime. General advice is given on procedures, documentation, and recording of the examination, and the article indicates how these features may differ from those used in investigation of natural disease. It also discusses evidence management, including recordkeeping, identification of evidence, labeling of photographs, and use of standard operating procedures and protocols. Various written and visual methods for documentation of the forensic necropsy are covered, and adjunctive topics such as sample collection, assessment, and description of wounds and taphonomy are included. Cause, mechanism, and manner of death are defined, and guidance to the use of these terms is given. The aim of this article is to offer guidance on procedural aspects of the forensic necropsy that will help those developing their forensic services, contribute to standardization of the provision of forensic veterinary pathology, and build the confidence of the "uncomfortable" forensic veterinary pathologist. © The Author(s) 2016.

  4. The Photochemical Reflectance Index (PRI) 20 years later: what have we learned?

    NASA Astrophysics Data System (ADS)

    Gamon, J. A.

    2012-12-01

    The Photochemical Reflectance Index (PRI) was originally derived as a measure of diurnal xanthophyll cycle activity and photosynthetic light-use efficiency (LUE). Based on experimental studies of plant canopies in the early 1990's, PRI is derived from reflectance at two wavelengths: 531 nm (the xanthophyll cycle wavelength) and a reference wavelength (unaffected by the xanthophyll cycle). Like any index approach, it has key advantages and disadvantages. Advantages include data reduction and a demonstrated correlation with biochemical and physiological processes tied to photosynthetic light regulation. Disadvantages include sensitivity to a number of confounding factors that include pigment pool sizes, vegetation canopy structure, and sun and view angle effects. Despite these challenges, many studies have shown some promise in using this index for airborne or satellite assessment of photosynthetic activity. This presentation will review key challenges in using this index for global assessment of photosynthetic activity, and will propose avenues for further research that might strengthen our understanding of the dynamic 531 nm reflectance signal. Alternative and complementary approaches to this index will also be briefly discussed.

  5. Limiting excessive postoperative blood transfusion after cardiac procedures. A review.

    PubMed Central

    Ferraris, V A; Ferraris, S P

    1995-01-01

    Analysis of blood product use after cardiac operations reveals that a few patients (< or = 20%) consume the majority of blood products (> 80%). The risk factors that predispose a minority of patients to excessive blood use include patient-related factors, transfusion practices, drug-related causes, and procedure-related factors. Multivariate studies suggest that patient age and red blood cell volume are independent patient-related variables that predict excessive blood product transfusion after cardiac procedures. Other factors include preoperative aspirin ingestion, type of operation, over- or underutilization of heparin during cardiopulmonary bypass, failure to correct hypothermia after cardiopulmonary bypass, and physician overtransfusion. A survey of the currently available blood conservation techniques reveals 5 that stand out as reliable methods: 1) high-dose aprotinin therapy, 2) preoperative erythropoietin therapy when time permits adequate dosage before operation, 3) hemodilution by harvest of whole blood immediately before cardiopulmonary bypass, 4) autologous predonation of blood, and 5) salvage of oxygenator blood after cardiopulmonary bypass. Other methods, such as the use of epsilon-aminocaproic acid or desmopressin, cell saving devices, reinfusion of shed mediastinal blood, and hemofiltration have been reported to be less reliable and may even be harmful in some high-risk patients. Consideration of the available data allows formulation of a 4-pronged plan for limiting excessive blood transfusion after surgery: 1) recognize the causes of excessive transfusion, including the importance of red blood cell volume, type of procedure being performed, preoperative aspirin ingestion, etc.; 2) establish a quality management program, including a survey of transfusion practices that emphasizes physician education and availability of real-time laboratory testing to guide transfusion therapy; 3) adopt a multimodal approach using institution-proven techniques; and

  6. 23 CFR 230.409 - Contract compliance review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... female labor forces within a reasonable recruitment area; (3) Working on projects that include special... project(s) is located and adjacent counties. (c) Contractor notification (Action R-3). (1) The Compliance Specialist should usually provide written notification to the contractor of the pending compliance review at...

  7. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... title IV-E agency must also analyze and explain its performance in meeting the national standards for the statewide/Tribal service area data indicators; (3) Assess the characteristics of the title IV-E... selected for the on-site review; and (iv) Interviews with key stakeholders, both internal and external to...

  8. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... in a journal article which has not been subjected to EPA review: “Although the research described in this article has been funded wholly or in part by the United States Environmental Protection Agency... Project Officer, at least 30 days prior to publication, a copy of any paper, article, or other...

  9. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... publish, in a scientific journal, material resulting directly or indirectly from work performed under this... in a journal article which has not been subjected to EPA review: “Although the research described in....” (3) Following publication of the journal article, the Contractor shall submit five copies of...

  10. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE... representing the best interests of the child. (5) The sample will range from 30-50 cases. Foster care cases... include children who entered foster care during the year under review. In-home cases must be drawn...

  11. 33 CFR 51.9 - Discharge review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Armed Forces of the United States, along with any other statements, affidavits or documentation desired... writing to the Armed Forces Review/Correction Board Reading Room, Pentagon Concourse, Washington, DC 20310... the case was on the motion of the DRB; (2) Changes in discharge policy occur; or (3) New,...

  12. 33 CFR 51.9 - Discharge review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Armed Forces of the United States, along with any other statements, affidavits or documentation desired... writing to the Armed Forces Review/Correction Board Reading Room, Pentagon Concourse, Washington, DC 20310... the case was on the motion of the DRB; (2) Changes in discharge policy occur; or (3) New,...

  13. 33 CFR 51.9 - Discharge review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Armed Forces of the United States, along with any other statements, affidavits or documentation desired... writing to the Armed Forces Review/Correction Board Reading Room, Pentagon Concourse, Washington, DC 20310... the case was on the motion of the DRB; (2) Changes in discharge policy occur; or (3) New,...

  14. Review of Monitoring Procedures with Mildly Handicapped Students.

    ERIC Educational Resources Information Center

    Fuchs, Lynn S.

    This paper presents a comprehensive review of special and remedial education practice in formative evaluation of goal attainment among mildly handicapped students. First, the relationship of formative evaluation to the range of special education assessment practice and its importance to the field are described. Then, four critical issues in…

  15. 40 CFR 501.31 - Review and approval procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SLUDGE MANAGEMENT PROGRAM REGULATIONS Program Approval, Revision and Withdrawal § 501.31 Review and... sludge management program within 90 days after receiving a complete program submission. (b) Within 30... questions; and (6) Briefly outline the fundamental aspects of the State's proposed program, and the process...

  16. 23 CFR 230.409 - Contract compliance review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... from which the contractor recruits employees, i.e., reasonable recruitment area; (iii) Standard... employees unless requested or approved by Washington Headquarters; and (9) For compliance reviews based on... Federal, State, or local agency regarding the contractor or any source of employees; (vi) A list of...

  17. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE...: (1) Address each systemic factor under review including the statewide/Tribal information system;...

  18. Canopy Level Chlorophyll Fluorescence and the PRI in a Cornfield

    NASA Technical Reports Server (NTRS)

    Middleton, Elizabeth M.; Cheng, Yen-Ben; Corp, Lawrence A.; Campbell, Petya K. E.; Huemmrich, K. Fred; Zhang, Qingyuan; Kustas, William P.

    2012-01-01

    Two bio-indicators, the Photochemical Reflectance Index (PRI) and solar-induced red and far-red Chlorophyll Fluorescence (SIF), were derived from directional hyperspectral observations and studied in a cornfield on two contrasting days in the growing season. Both red and far-red SIF exhibited higher values on the day when the canopy in the early senescent stage, but only the far-red SIF showed sensitivity to viewing geometry. Consequently, the red/far-red SIF ratio varied greatly among azimuth positions while the largest values were obtained for the "hotspot" at both growth stages. This ratio was lower (approx.0.88 +/- 0.4) in early July than in August when the ratio approached equivalence (near approx.1). In concert, the PRI exhibited stronger responses to both zenith and azimuth angles and different values on the two growth stages. The potential of using these indices to monitor photosynthetic activities needs further investigation

  19. 42 CFR 423.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Procedures before the Departmental Appeals Board on review. 423.1080 Section 423.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... 423.1016. ...

  20. 78 FR 64234 - 30-Day Notice of Proposed Information Collection: Environmental Review Procedures for Entities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... Entities Assuming HUD Environmental Responsibilities AGENCY: Office of the Chief Information Officer, HUD... Responsibilities. OMB Approval Number: 2506-0087. Type of Request: Revision of a currently approved collection..., ``Environmental Review Procedures for Entities Assuming HUD Environmental Responsibilities'' requires units...

  1. 29 CFR 2570.12 - Procedures for review by the Secretary.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Civil Sanctions Under ERISA Section 502(i) § 2570.12 Procedures for review by the Secretary. (a) Upon...) taken. Such decision by the Secretary shall be final agency action within the meaning of 5 U.S.C. 704....

  2. 29 CFR 2570.71 - Procedures for review by the Secretary.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Civil Penalties Under ERISA Section 502(c)(2) § 2570.71 Procedures for review by the Secretary. (a) Upon...(s) taken. Such decision by the Secretary shall be final agency action within the meaning of 5...

  3. 29 CFR 2570.101 - Procedures for review by the Secretary.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Civil Penalties Under ERISA Section 502(c)(5) § 2570.101 Procedures for review by the Secretary. (a... the action(s) taken. Such decision by the Secretary shall be final agency action within the meaning...

  4. 29 CFR 503.51 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATIONS ENFORCEMENT OF OBLIGATIONS FOR TEMPORARY NONIMMIGRANT NON-AGRICULTURAL WORKERS ADMITTED UNDER... Administrative Law Judge's Decision § 503.51 Procedures for initiating and undertaking review. (a) A...

  5. 29 CFR 503.51 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REGULATIONS ENFORCEMENT OF OBLIGATIONS FOR TEMPORARY NONIMMIGRANT NON-AGRICULTURAL WORKERS ADMITTED UNDER... Administrative Law Judge's Decision § 503.51 Procedures for initiating and undertaking review. (a) A...

  6. 29 CFR 503.51 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REGULATIONS ENFORCEMENT OF OBLIGATIONS FOR TEMPORARY NONIMMIGRANT NON-AGRICULTURAL WORKERS ADMITTED UNDER... Administrative Law Judge's Decision § 503.51 Procedures for initiating and undertaking review. (a) A...

  7. A review of the regenerative endodontic treatment procedure

    PubMed Central

    Lee, Bin-Na; Moon, Jong-Wook; Chang, Hoon-Sang; Hwang, In-Nam; Oh, Won-Mann

    2015-01-01

    Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment. PMID:26295020

  8. A review of the regenerative endodontic treatment procedure.

    PubMed

    Lee, Bin-Na; Moon, Jong-Wook; Chang, Hoon-Sang; Hwang, In-Nam; Oh, Won-Mann; Hwang, Yun-Chan

    2015-08-01

    Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment.

  9. The Primitive Material Explorer (PriME) Mission

    NASA Astrophysics Data System (ADS)

    Cochran, Anita L.; Weaver, H. A.; Science, PriME; Engineering Teams

    2010-10-01

    The Primitive Material Explorer (PriME) Mission is a proposed Discovery mission that will rendezvous with comet 46P/Wirtanen in 2021 in order to 1) clarify the roles played by comets in the formation and evolution of the Solar System and the origin of life; 2) ascertain the bulk physical properties, the surface geology, and the sources of activity in a fresh comet nucleus; and 3) investigate the compositional diversity of primitive material in the Solar System. PriME teams an experienced group of comet scientists (led by PI Anita Cochran and by DPI Harold Weaver) with university and industrial partners. The PriME payload accomplishes the mission objectives with only three instruments. MASPEX (MAss Spectrometer for Planetary EXploration) has higher mass resolution and is more sensitive than any mass spectrometer ever flown. MASPEX will measure D/H in H2O, noble gases, isotopes of many species, and complex molecular compounds to test solar nebula models and the role comets played in delivering water and other biologically important materials throughout the Solar System. The VIS (Visible Imaging System), consisting of a Narrow Angle Camera (NAC) and Wide-Angle Camera (WAC), will constrain the conditions under which the building blocks of the outer Solar System were assembled by measuring key physical properties of the nucleus of 46P/Wirtanen. Using the radio antenna and close flybys of the nucleus, PriME will determine the mass of the nucleus to an accuracy of 1% and the bulk density and average porosity of the nucleus to better than 5%. All spacecraft subsystems have significant planetary flight heritage. The spacecraft is a high-heritage derivative of the Kepler and Deep Impact spacecrafts, compatible with the three launch vehicle families specified in the Discovery Announcement of Opportunity.

  10. Tooth-bleaching procedures and their controversial effects: A literature review

    PubMed Central

    Alqahtani, Mohammed Q.

    2014-01-01

    Aim This review article will help clinicians improve their understanding of the history of bleaching procedures, bleaching types, components, mechanisms, and their effects on soft tissue, tooth structures, resin composite, and bonding. Methods The controversial issues about bleaching procedures and their effects are reviewed. Additionally, the consequences of pre- and post-bleaching on the bonding potential of composite resin restorations to tooth structure are discussed. Conclusion The overall goal of the paper is to help reduce risks for patients. PMID:25408594

  11. Judgments of Restrictiveness, Social Acceptability, and Usage: Review of Research on Procedures to Decrease Behavior.

    ERIC Educational Resources Information Center

    Morgan, Robert L.

    1989-01-01

    The article reviewed research on professionals', consumers', and others' judgments of the restrictiveness, social acceptability, and estimated frequency of use of procedures to decrease problem behaviors of disabled persons. Most respondents agreed that more restrictive procedures should be used as a last resort and that less restrictive…

  12. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  13. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  14. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  15. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  16. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  17. 29 CFR 530.407 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Procedures for initiating and undertaking review. 530.407 Section 530.407 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS EMPLOYMENT OF HOMEWORKERS IN CERTAIN INDUSTRIES Administrative Procedures § 530.407...

  18. 42 CFR 498.85 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Procedures before the Departmental Appeals Board on review. 498.85 Section 498.85 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION APPEALS PROCEDURES FOR...

  19. A Review of Different Estimation Procedures in the Rasch Model. Research Report 87-6.

    ERIC Educational Resources Information Center

    Engelen, R. J. H.

    A short review of the different estimation procedures that have been used in association with the Rasch model is provided. These procedures include joint, conditional, and marginal maximum likelihood methods; Bayesian methods; minimum chi-square methods; and paired comparison estimation. A comparison of the marginal maximum likelihood estimation…

  20. A review: the application of minimally invasive surgery to pediatric urology: upper urinary tract procedures.

    PubMed

    Traxel, Erica J; Minevich, Eugene A; Noh, Paul H

    2010-07-01

    This paper is one-half of a 2 part review on minimally-invasive procedures in pediatric urology. This article focuses on upper tract procedures, including complete nephrectomy, partial nephrectomy, pyeloplasty, and ureterocalicostomy. We note important articles on pure laparoscopic as well as robotic-assisted laparoscopic upper urinary tract surgeries, concentrating on their techniques and outcomes.

  1. A review: the application of minimally invasive surgery to pediatric urology: lower urinary tract reconstructive procedures.

    PubMed

    Traxel, Erica J; Minevich, Eugene A; Noh, Paul H

    2010-07-01

    This paper is one-half of a 2 part review on minimally-invasive procedures in pediatric urology. This article focuses on lower tract procedures, including ureteroureterostomy, anti-reflux surgeries, creation of continent catheterizable channels, and augmentation cystoplasty. We note important articles on pure laparoscopic as well as robotic-assisted laparoscopic lower urinary tract surgeries, concentrating on their techniques and outcomes.

  2. Prodifferentiation Activity of Novel Vitamin D₂ Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells.

    PubMed

    Nachliely, Matan; Sharony, Ehud; Bolla, Narasimha Rao; Kutner, Andrzej; Danilenko, Michael

    2016-07-05

    1α,25-dihydroxyvitamin D₃ (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D₂ is less toxic than vitamin D₃ in animals. Here, we determined the differentiation effects of novel analogs of 1α,25-dihydroxyvitamin D₂ (1,25D2), PRI-1916 and PRI-1917, in which the extended side chains of their previously reported precursors (PRI-1906 and PRI-1907, respectively) underwent further 24Z (24-cis) modification. Using four human AML cell lines representing different stages of myeloid maturation (KG-1a, HL60, U937, and MOLM-13), we found that the potency of PRI-1916 was slightly higher or equal to that of PRI-1906 while PRI-1917 was significantly less potent than PRI-1907. We also demonstrated that 1,25D2 was a less effective differentiation agent than 1,25D3 in these cell lines. Irrespective of their differentiation potency, all the vitamin D₂ derivatives tested were less potent than 1,25D3 in transactivating the DR3-type vitamin D response elements. However, similar to 1,25D3, both 1,25D2 and its analogs could strongly cooperate with the plant polyphenol carnosic acid in inducing cell differentiation and inhibition of G1-S cell cycle transition. These results indicate that the 24Z modification has contrasting effects on the differentiation ability of PRI-1906 and PRI-1907 and that the addition of a plant polyphenol could result in a similar extent of cell differentiation induced by different vitamin D compounds. The enhanced antileukemic effects of the tested combinations may constitute the basis for the development of novel approaches for differentiation therapy of AML.

  3. Discolouration potential of endodontic procedures and materials: a review.

    PubMed

    Ahmed, H M A; Abbott, P V

    2012-10-01

    Advances in endodontic materials and techniques are at the forefront of endodontic research. Despite continuous improvements, tooth discolouration, especially in anterior teeth, is considered an undesirable consequence following endodontic treatment as it creates a range of aesthetic problems. This article aims to discuss the intrinsic and internalized tooth discolouration caused by endodontic procedures, and to address the discolouration potential of materials used during root canal treatment, including root canal irrigants, intra-canal medicaments, endodontic and post-endodontic filling materials. In addition, the discolouration patterns caused by combined endodontic and nonendodontic aetiological factors are discussed. The recommended guidelines that should be followed by dental practitioners to prevent and manage tooth discolouration are also outlined. © 2012 International Endodontic Journal.

  4. Systematic reviews of surgical procedures in children: quantity, coverage and quality.

    PubMed

    McGee, Richard G; Craig, Jonathan C; Rogerson, Thomas E; Webster, Angela C

    2013-04-01

    Systematic reviews have the potential to map those areas where children are under-represented in surgical research. We aimed to describe and evaluate the quantity, coverage and the quality of conduct and reporting of systematic reviews of surgical procedures in children. We searched four biomedical databases, a systematic review register, reference lists and conducted hand searching to identify relevant reviews. Two reviewers worked independently to critically appraise included studies and abstract data. We assessed reporting quality using the preferred reporting items for systematic reviews and meta-analysis statement and methodological quality using the Assessment of Multiple SysTemAtic Reviews tool. Fifteen systematic reviews were identified, representing 0.01% of all paediatric surgical citations in MEDLINE and Embase. Thirteen of the reviews were Cochrane reviews, and most reviews (12/15) addressed subspecialty interests such as otorhinolaryngology. The median number of included trials per systematic review was four (interquartile range 1 to 9.5), the median number of primary outcomes was 5.5 (interquartile range 3.5 to 7.5). In general, reporting and methodological quality was good although there were several omissions, particularly around completeness of reporting of statistical methods used, and utilisation of quality assessments in analyses. Outcomes were often not clearly defined and descriptions of procedures lacked sufficient detail to determine the similarities and differences among surgical procedures within the contributing trials. Systematic reviews of surgical procedures in children are rarely published. To improve the evidence base and guide research agendas, more systematic reviews should be conducted, using standard guidelines for conduct and reporting. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  5. A review of mechanisms and modelling procedures for landslide tsunamis

    NASA Astrophysics Data System (ADS)

    Løvholt, Finn; Harbitz, Carl B.; Glimsdal, Sylfest

    2017-04-01

    Landslides, including volcano flank collapses or volcanically induced flows, constitute the second-most important cause of tsunamis after earthquakes. Compared to earthquakes, landslides are more diverse with respect to how they generation tsunamis. Here, we give an overview over the main tsunami generation mechanisms for landslide tsunamis. In the presentation, a mix of results using analytical models, numerical models, laboratory experiments, and case studies are used to illustrate the diversity, but also to point out some common characteristics. Different numerical modelling techniques for the landslide evolution, and the tsunami generation and propagation, as well as the effect of frequency dispersion, are also briefly discussed. Basic tsunami generation mechanisms for different types of landslides, including large submarine translational landslide, to impulsive submarine slumps, and violent subaerial landslides and volcano flank collapses, are reviewed. The importance of the landslide kinematics is given attention, including the interplay between landslide acceleration, landslide velocity to depth ratio (Froude number) and dimensions. Using numerical simulations, we demonstrate how landslide deformation and retrogressive failure development influence tsunamigenesis. Generation mechanisms for subaerial landslides, are reviewed by means of scaling relations from laboratory experiments and numerical modelling. Finally, it is demonstrated how the different degree of complexity in the landslide tsunamigenesis needs to be reflected by increased sophistication in numerical models.

  6. Review of numerical procedures for computational surface thermochemistry

    NASA Technical Reports Server (NTRS)

    Milos, Frank S.; Rasky, Daniel J.

    1994-01-01

    Models and equations for surface thermochemistry and near-surface thermophysics of aerodynamically heated thermal protection materials are reviewed, with particular emphasis on computational boundary conditions for surface mass and energy transfer. The surface energy and mass balances, coupled with an appropriate ablation or surface catalysis model, provide complete thermochemical boundary conditions for a true multidisciplinary solution of the fully coupled fluid-dynamics/solid mechanics problem. Practical approximate solutions can be obtained by using a detailed model with full thermophysics for either the solid or fluid phase and a semianalytic method for the other half of the problem. A significant increase in the state-of-the-art in aerothermal computational fluid dynamics is possible by uniting computational fluid dynamic (CFD) methodology with surface thermochemistry boundary conditions and the heat-balance-integral method.

  7. 20 CFR 410.695 - Procedure before Appeals Council on review of hearing officer's decision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Procedure before Appeals Council on review of hearing officer's decision. 410.695 Section 410.695 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Disability, Other Determinations, Administrative Review, Finality of Decisions, and Representation of...

  8. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... COVERAGE DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review... than 90 days, by which the contractor completes the reconsideration; or (ii) For NCDs, in compliance...— (i) For LCDs, the 90-day reconsideration timeframe; or (ii) For NCDs, the reconsideration...

  9. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... COVERAGE DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review... than 90 days, by which the contractor completes the reconsideration; or (ii) For NCDs, in compliance...— (i) For LCDs, the 90-day reconsideration timeframe; or (ii) For NCDs, the reconsideration...

  10. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review of new evidence... contractor completes the reconsideration; or (ii) For NCDs, in compliance with the timeframes specified in... timeframe; or (ii) For NCDs, the reconsideration timeframe specified by the Board, in compliance...

  11. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review of new evidence... contractor completes the reconsideration; or (ii) For NCDs, in compliance with the timeframes specified in... timeframe; or (ii) For NCDs, the reconsideration timeframe specified by the Board, in compliance...

  12. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... COVERAGE DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review... than 90 days, by which the contractor completes the reconsideration; or (ii) For NCDs, in compliance...— (i) For LCDs, the 90-day reconsideration timeframe; or (ii) For NCDs, the reconsideration...

  13. Procedures for Reviewing Environmental Impact Assessments and Statements for Construction Projects.

    DTIC Science & Technology

    This report presents systematic procedures designed to assist administrative and staff personnel in quickly and accurately reviewing environmental ... impact assessments and statements (EIA/EIS). In addition, these guidelines will help the EIA/EIS preparer and reviewer assess the completeness and

  14. 15 CFR 400.32 - Procedure for review of request for approval of manufacturing or processing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Procedure for review of request for approval of manufacturing or processing. 400.32 Section 400.32 Commerce and Foreign Trade Regulations... REGULATIONS OF THE FOREIGN-TRADE ZONES BOARD Manufacturing and Processing Activity-Reviews § 400.32...

  15. 15 CFR 400.32 - Procedure for review of request for approval of manufacturing or processing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Procedure for review of request for approval of manufacturing or processing. 400.32 Section 400.32 Commerce and Foreign Trade Regulations... REGULATIONS OF THE FOREIGN-TRADE ZONES BOARD Manufacturing and Processing Activity-Reviews § 400.32...

  16. 15 CFR 400.32 - Procedure for review of request for approval of manufacturing or processing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Procedure for review of request for approval of manufacturing or processing. 400.32 Section 400.32 Commerce and Foreign Trade Regulations... REGULATIONS OF THE FOREIGN-TRADE ZONES BOARD Manufacturing and Processing Activity-Reviews § 400.32...

  17. Injection therapy and denervation procedures for chronic low-back pain: a systematic review

    PubMed Central

    Kuijpers, Ton; Rubinstein, Sidney M.; van Middelkoop, Marienke; Ostelo, Raymond; Verhagen, Arianne; Koes, Bart W.; van Tulder, Maurits W.

    2010-01-01

    Injection therapy and denervation procedures are commonly used in the management of chronic low-back pain (LBP) despite uncertainty regarding their effectiveness and safety. To provide an evaluation of the current evidence associated with the use of these procedures, a systematic review was performed. Existing systematic reviews were screened, and the Cochrane Back Review Group trial register was searched for randomized controlled trials (RCTs) fulfilling the inclusion criteria. Studies were included if they recruited adults with chronic LBP, evaluated the use of injection therapy or denervation procedures and measured at least one clinically relevant outcome (such as pain or functional status). Two review authors independently assessed studies for eligibility and risk of bias (RoB). A meta-analysis was performed with clinically homogeneous studies, and the GRADE approach was used to determine the quality of evidence. In total, 27 RCTs were included, 14 on injection therapy and 13 on denervation procedures. 18 (66%) of the studies were determined to have a low RoB. Because of clinical heterogeneity, only two comparisons could be pooled. Overall, there is only low to very low quality evidence to support the use of injection therapy and denervation procedures over placebo or other treatments for patients with chronic LBP. However, it cannot be ruled out that in carefully selected patients, some injection therapy or denervation procedures may be of benefit. PMID:20424870

  18. Relationships between the photochemical reflectance index (PRI) and chlorophyll fluorescence parameters and plant pigment indices at different leaf growth stages.

    PubMed

    Rahimzadeh-Bajgiran, Parinaz; Munehiro, Masashi; Omasa, Kenji

    2012-09-01

    This study aimed to evaluate the photochemical reflectance index (PRI) for assessing plant photosynthetic performance throughout the plant life cycle. The relationships between PRI, chlorophyll fluorescence parameters, and leaf pigment indices in Solanum melongena L. (aubergine; eggplant) were studied using photosynthetic induction curves both in short-term (diurnal) and long-term (seasonal) periods under different light intensities. We found good correlations between PRI/non-photochemical quenching (NPQ) and PRI/electron transport rate (ETR) in the short term at the same site of a single leaf but these relationships did not hold throughout the life of the plant. In general, changes in PRI owing to NPQ or ETR variations in the short term were <20 % of those that occurred with leaf aging. Results also showed that PRI was highly correlated to plant pigments, especially chlorophyll indices measured by spectral reflectance. Moreover, relationships of steady-state PRI/ETR and steady-state PRI/photochemical yield of photosystem II (Φ(PSII)) measured at uniform light intensity at different life stages proved that overall photosynthesis capacity and steady-state PRI were better correlated through chlorophyll content than NPQ and xanthophylls. The calibrated PRI index accommodated these pigments effects and gave better correlation with NPQ and ETR than PRI. Further studies of PRI indices based on pigments other than xanthophylls, and studies on PRI mechanisms in different species are recommended.

  19. A Review of Clinical Data for Currently Approved Hysteroscopic Sterilization Procedures

    PubMed Central

    Basinski, Cindy M

    2010-01-01

    Two hysteroscopic permanent sterilization procedures are approved for use in the United States: Essure® Permanent Birth Control System (Conceptus Incorporated, Mountain View, CA) and Adiana® Permanent Contraception (Hologic, Inc., Bedford, MA). This review compares the clinical trial data for these procedures. A notable difference is the resultant clinical pregnancy risk. The clinical trials for the Essure procedure have reported no pregnancies in 643 relying women in the 9 years since initiation of the studies. The clinical trial for the Adiana procedure has reported 12 pregnancies in 570 relying women in nearly 5 years of collected data. Other clinical outcome parameters concerning Essure and Adiana are examined in this review. PMID:21364861

  20. The Importance of PRI Therapy for the Pastoral Counsellor

    PubMed Central

    2009-01-01

    It is not always easy for pastoral counsellors to help people change. Often people have become stuck in their ways. Recent developments in the field of brain research help explain why change is difficult. This article discusses Past Reality Integration Therapy (PRI), a psychotherapeutic method that integrates recent findings of brain research and offers an important addition to the work of (pastoral) counsellors and psychotherapists. The use of this approach with Dutch students in their pastoral training is presented. Furthermore the importance of this new method for counsellors themselves, their clients and their work is discussed and some overall conclusions about the method and its practical application are presented. PMID:20835380

  1. Application of carbon nanosorbent for PRiME pass-through cleanup of 10 selected local anesthetic drugs in human plasma samples.

    PubMed

    Ma, Jian-Bo; Zhao, Li-Ming; Rui, Qiu-Hong; Liao, Yu-Feng; Chen, Yan-Min; Xu, Jin; Zhu, Yan; Zhao, Yong-Gang

    2017-04-01

    A novel PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure has been developed to improve the existing commercially available designs. Carbon nanosorbents, i.e., magnetic modified carboxyl-graphene (Mag-CG) and magnetic modified carboxyl-carbon nanotubes (Mag-CCNTs), have been synthesised and evaluated in PRiME pass-through cleanup procedure for human plasma prior to analysis of 10 selected local anesthetic drugs by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS). The matrix effect, an interesting phenomenon of ion suppression for local anesthetic drugs containing ester group and ion enhancement for other drugs containing acylamino group, has been minimized using carbon nanosorbents PRiME pass-through cleanup procedure. Under the optimal conditions, the obtained results show higher cleanup efficiency of the carbon nanosorbents with recoveries between 70.2% and 126%. Furthermore, the carbon nanosorbents are also evaluated for reuse up to 80-100 times. The limits of quantification (LOQs) for local anesthetic drugs are in the range of 0.024-0.15 μg/L. Validation results on linearity, specificity, accuracy, and precision, as well as the application to the analysis of lidocaine in five patients recruited from the lung cancer demonstrate the applicability to clinical studies.

  2. STS-34 crewmembers review IFM procedures on JSC's CCT mockup middeck

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-34 crewmembers review inflight maintenance (IFM) procedures on the middeck of JSC's crew compartment trainer (CCT) located in the Mockup and Integration Laboratory (MAIL) Bldg 9A. IFM trainer, holding cable, discusses procedures with Mission Specialist (MS) Ellen S. Baker (center) and Pilot Michael J. McCulley. An open stowage locker appears in front of the group. Visible on the mockup's middeck are forward and aft stowage lockers, the airlock hatch, and the starboard wall mounted sleep restraints.

  3. Learning curves for cardiothoracic and vascular surgical procedures--a systematic review.

    PubMed

    Arora, Karan Singh; Khan, Nuzhath; Abboudi, Hamid; Khan, Mohammed S; Dasgupta, Prokar; Ahmed, Kamran

    2015-03-01

    The aim of this systematic review is to evaluate the learning curve (LC) literature and identify the LC of cardiothoracic and vascular surgical procedures. The LC describes an observation that a learner's performance improves over time during acquisition of new motor skills. Measuring the LC of surgical procedures has important implications for surgical innovation, education, and patient safety. Numerous studies have investigated LCs of isolated operations in cardiothoracic and vascular surgeries, but a lack of uniformity in the methods and variables used to measure LCs has led to a lack of systematic reviews. The MEDLINE®, EMBASE™, and PsycINFO® databases were systematically searched until July 2013. Articles describing LCs for cardiothoracic and vascular procedures were included. The type of procedure, statistical analysis, number of participants, procedure setting, level of participants, outcomes, and LCs were reviewed. A total of 48 studies investigated LCs in cardiothoracic and vascular surgeries. Based on operating time, the LC for coronary artery bypass surgery ranged between 15 and 100 cases; for endoscopic vessel harvesting and other cardiac vessel surgery between 7 and 35 cases; for valvular surgery, which included repair and replacement, between 20 and 135 cases; for video-assisted thoracoscopic surgery, between 15 and 35 cases; for vascular neurosurgical procedures between 100 and 500 cases, based on complications; for endovascular vessel repairs between 5 and 40 cases; and for ablation procedures between 25 and 60 cases. However there was a distinct lack of standardization in the variables/outcome measures used, case selection, prior experience, and supervision of participating surgeons and a range of statistical analyses to compute LCs was noted. LCs in cardiothoracic and vascular procedures are hugely variable depending on the procedure type, outcome measures, level of prior experience, and methods/statistics used. Uniformity in methods

  4. 16 CFR 1028.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... HUMAN SUBJECTS § 1028.110 Expedited review procedures for certain kinds of research involving no more... of research proposals which have been approved under the procedure. (d) The department or agency head... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Expedited review procedures for certain...

  5. Retinoids: Literature Review and Suggested Algorithm for Use Prior to Facial Resurfacing Procedures

    PubMed Central

    Buchanan, Patrick J; Gilman, Robert H

    2016-01-01

    Vitamin A-containing products have been used topically since the early 1940s to treat various skin conditions. To date, there are four generations of retinoids, a family of Vitamin A-containing compounds. Tretinoin, all-trans-retinoic acid, is a first-generation, naturally occurring, retinoid. It is available, commercially, as a gel or cream. The authors conducted a complete review of all studies, clinical- and basic science-based studies, within the literature involving tretinoin treatment recommendations for impending facial procedures. The literature currently lacks definitive recommendations for the use of tretinoin-containing products prior to undergoing facial procedures. Tretinoin pretreatment regimens vary greatly in terms of the strength of retinoid used, the length of the pre-procedure treatment, and the ideal time to stop treatment before the procedure. Based on the current literature and personal experience, the authors set forth a set of guidelines for the use of tretinoin prior to various facial procedures. PMID:27761082

  6. Impact of 3D Rotational Angiography on Liver Embolization Procedures: Review of Technique and Applications

    SciTech Connect

    Lucatelli, Pierleone Corona, Mario Argirò, Renato Anzidei, Michele; Vallati, Giulio; Fanelli, Fabrizio Bezzi, Mario Catalano, Carlo

    2015-06-15

    In the last years, the interest into interventional applications of C-arm cone-beam CT (CBCT) progressively raised, widening its clinical application from the original field of interventional neuroradiology to the field of peripheral procedures. Liver embolization procedures, due to their complexity and potential treatment-related life-threatening complications, represent one of the main clinical applications of this novel angiographic technique. CBCT has been demonstrated to render procedures safer and technically easier, and to predict outcome as well as to avoid major complications in different treatment scenarios (trans-arterial embolization, trans-arterial chemoembolization, selective internal radiation therapy, percutaneous portal vein embolization). This review summarizes all technical, dosimetric and procedural aspects of CBCT techniques, underlying all its potential clinical advantages in the field of liver embolization procedures. Moreover, the paper provides all the instructions to obtain the best diagnostic performance out of this novel angiographic technique.

  7. Three causes of variation in the photochemical reflectance index (PRI) in evergreen conifers.

    PubMed

    Wong, Christopher Y S; Gamon, John A

    2015-04-01

    The photochemical reflectance index (PRI) reflects diurnal xanthophyll cycle activity and is also influenced by seasonally changing carotenoid : Chl pigment ratios. Both changing pigment pools and xanthophyll cycle activity contribute to photoprotection in evergreen conifers exposed to boreal winters, but they operate over different timescales, and their relative contribution to the PRI signal has often been unclear. To clarify these responses and their contribution to the PRI signal, leaf PRI, pigment composition, temperature and irradiance were monitored over 2 yr for two evergreen conifers (Pinus contorta and Pinus ponderosa) in a boreal climate. PRI was affected by three distinct processes operating over different timescales and exhibiting contrasting spectral responses. Over the 2 yr study period, the greatest change in PRI resulted from seasonally changing carotenoid : Chl pigment ratios, followed by a previously unreported shifting leaf albedo during periods of deep cold. Remarkably, the smallest change was attributable to the xanthophyll cycle. To properly distinguish these three effects, interpretation of PRI must consider temporal context, physiological responses to evolving environmental conditions, and spectral response. Consideration of the separate mechanisms affecting PRI over different timescales could greatly improve efforts to monitor changing photosynthetic activity using optical remote sensing.

  8. Draft genome sequence of the antagonistic rhizosphere bacterium Serratia plymuthica strain PRI-2C.

    PubMed

    Garbeva, P; van Elsas, J D; de Boer, W

    2012-08-01

    Serratia plymuthica strain PRI-2C is a rhizosphere bacterial strain with antagonistic activity against different plant pathogens. Here we present the 5.39-Mb (G+C content, 55.67%) draft genome sequence of S. plymuthica strain PRI-2C with the aim of providing insight into the genomic basis of its antagonistic activity.

  9. Partnership for Rural Improvement: PRI in Transition. Annual Report 1979-80.

    ERIC Educational Resources Information Center

    Hagood, Richard A.; And Others

    Covering 1979-80, which was the final year of the initial four year grant period for the Partnership for Rural Improvement (PRI), this report details the major assessments and program adjustments made during that year. Several program developments of critical importance to understanding the transition occurring in PRI are highlighted in the…

  10. Diffuse sky radiation influences the relationship between canopy PRI and shadow fraction

    NASA Astrophysics Data System (ADS)

    Mõttus, Matti; Takala, Tuure L. H.; Stenberg, Pauline; Knyazikhin, Yuri; Yang, Bin; Nilson, Tiit

    2015-07-01

    The Photochemical Reflectance Index (PRI) of green leaves is an indicator of photosynthetic downregulation: when the photosynthetic apparatus is close to the saturation limit, PRI becomes dependent on light conditions. Therefore, by measuring the PRI of leaves under different local irradiance conditions, it should be possible to determine the saturation level of the leaves and obtain information on the light use efficiency (LUE) of a vegetation canopy. The dependence of PRI on the ratio of sunlit to shaded foliage (quantified by the canopy shadow fraction) in the field of view of an instrument has been used to remotely measure canopy LUE on clear days. However, besides photosynthetic downregulation, the dependence of canopy PRI on shadow fraction is affected by the blue sky radiation caused by scattering in the atmosphere. To quantify this effect on remotely sensed PRI, we present the underlying definitions relating leaf and canopy PRI and perform the required calculations for typical midsummer conditions in Central Finland. We demonstrate that the effect of blue sky radiation on the variation of PRI with canopy shadow fraction is similar in shape and magnitude to that of LUE variations reported in literature.

  11. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein.

    PubMed

    Wessel, Sarah R; Marceau, Aimee H; Massoni, Shawn C; Zhou, Ruobo; Ha, Taekjip; Sandler, Steven J; Keck, James L

    2013-06-14

    Frequent collisions between cellular DNA replication complexes (replisomes) and obstacles such as damaged DNA or frozen protein complexes make DNA replication fork progression surprisingly sporadic. These collisions can lead to the ejection of replisomes prior to completion of replication, which, if left unrepaired, results in bacterial cell death. As such, bacteria have evolved DNA replication restart mechanisms that function to reload replisomes onto abandoned DNA replication forks. Here, we define a direct interaction between PriC, a key Escherichia coli DNA replication restart protein, and the single-stranded DNA-binding protein (SSB), a protein that is ubiquitously associated with DNA replication forks. PriC/SSB complex formation requires evolutionarily conserved residues from both proteins, including a pair of Arg residues from PriC and the C terminus of SSB. In vitro, disruption of the PriC/SSB interface by sequence changes in either protein blocks the first step of DNA replication restart, reloading of the replicative DnaB helicase onto an abandoned replication fork. Consistent with the critical role of PriC/SSB complex formation in DNA replication restart, PriC variants that cannot bind SSB are non-functional in vivo. Single-molecule experiments demonstrate that PriC binding to SSB alters SSB/DNA complexes, exposing single-stranded DNA and creating a platform for other proteins to bind. These data lead to a model in which PriC interaction with SSB remodels SSB/DNA structures at abandoned DNA replication forks to create a DNA structure that is competent for DnaB loading.

  12. New insights into pri-miRNA processing and accumulation in plants.

    PubMed

    Zhang, Shuxin; Liu, Yuhui; Yu, Bin

    2015-01-01

    MicroRNAs (miRNAs) regulate many biological processes such as development, metabolism, and others. They are processed from their primary transcripts called primary miRNA transcripts (pri-miRNAs) by the processor complex containing the RNAse III enzyme, DICER-LIKE1 (DCL1), in plants. Consequently, miRNA biogenesis is controlled through altering pri-miRNA accumulation and processing, which is crucial for plant development and adaptation to environmental changes. Plant pri-miRNAs are transcribed by DNA-dependent RNA polymerase II (Pol II) and their levels are determined through transcription and degradation, whereas pri-miRNA processing is affected by its structure, splicing, alternative splicing, loading to the processor and the processor activity, which involve in many accessory proteins. Here, we summarize recent progresses related to pri-miRNA transcription, stability, and processing in plants.

  13. Evidence for a cytoplasmic microprocessor of pri-miRNAs.

    PubMed

    Shapiro, Jillian S; Langlois, Ryan A; Pham, Alissa M; Tenoever, Benjamin R

    2012-07-01

    microRNAs (miRNAs) represent a class of noncoding RNAs that fine-tune gene expression through post-transcriptional silencing. While miRNA biogenesis occurs in a stepwise fashion, initiated by the nuclear microprocessor, rare noncanonical miRNAs have also been identified. Here we characterize the molecular components and unique attributes associated with the processing of virus-derived cytoplasmic primary miRNAs (c-pri-miRNAs). RNA in situ hybridization and inhibition of cellular division demonstrated a complete lack of nuclear involvement in c-pri-miRNA cleavage while genetic studies revealed that maturation still relied on the canonical nuclear RNase III enzyme, Drosha. The involvement of Drosha was mediated by a dramatic relocalization to the cytoplasm following virus infection. Deep sequencing analyses revealed that the cytoplasmic localization of Drosha does not impact the endogenous miRNA landscape during infection, despite allowing for robust synthesis of virus-derived miRNAs in the cytoplasm. Taken together, this research describes a unique function for Drosha in the processing of highly structured cytoplasmic RNAs in the context of virus infection.

  14. 36 CFR 1260.42 - What are the procedures for agency personnel to review records at a NARA facility?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SECURITY INFORMATION Systematic Review § 1260.42 What are the procedures for agency personnel to review... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false What are the procedures for agency personnel to review records at a NARA facility? 1260.42 Section 1260.42 Parks, Forests, and Public...

  15. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false What are the procedures for using a multiple tier... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review...

  16. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false What are the procedures for using a multiple tier... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review...

  17. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false What are the procedures for using a multiple tier... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review...

  18. 21 CFR 56.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Expedited review procedures for certain kinds of....110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL INSTITUTIONAL REVIEW BOARDS IRB Functions and Operations § 56.110 Expedited review procedures for certain kinds...

  19. Impact of video review on surgical procedure determination for patients with cerebral palsy.

    PubMed

    Carlson, Michelle G; Spincola, Laura J; Lewin, Jennifer; McDermott, Erin

    2009-09-01

    Evaluation of patients with cerebral palsy is complex and variable. Several examinations, including video analysis, are necessary as part of the surgical planning process. Videotaped evaluation of the upper extremity in children with cerebral palsy has been used as an objective assessment of functional ability and deformity. The effect of review of these videotaped evaluations on altering the initially proposed surgical plan has not been evaluated. This is a retrospective study completed through a chart review. Inclusion criteria were all patients with cerebral palsy having upper extremity surgical consultation with the primary investigator (M.G.C.) between 1995 and 2005, having at least 2 presurgical consultations, completing a videotaped evaluation, and proceeding to surgery. Of 167 new patients, 94 patients, having 430 procedures, were eligible for the study. Five distinct anatomical areas (elbow, forearm, wrist, digit, and thumb) were delineated. Changes to the initial surgical plan based on a review of the videotaped evaluation were made for 77 patients (138 procedures) and carried through to surgery for 68 patients (108 procedures). Those procedure changes that carried through to surgery most often involved the thumb, wrist, and digit, as compared to the elbow and forearm. Videotaping evaluations allows for more precise understanding of ability and improves diagnosis. Changes to the initial presurgical plan were made in 77 patients (72%) after videotaped evaluation, most commonly for procedures addressing the wrist, digit, and thumb.

  20. Improving the review of standard operating procedures: a novel electronic system for compounding pharmacies.

    PubMed

    Brensel, Robert; Brensel, Scott; Ng, Amy

    2013-01-01

    Since the New England Compounding Center disaster in 2012, the importance of following correct procedures during every phase of customized pharmacy has been a focus of governmental interest and action as well as public scrutiny. Many pharmacies rely on the rote review of standard operating procedures to ensure that staff members understand and follow protocols that ensure the safety and potency of all compounds prepared, but that approach to continuing education can be cumbersome and needlessly time-consuming. In addition, documenting and retrieving evidence of employee competence can be difficult. In this article, we describe our use of online technology to improve our methods of educating staff about the full range of standard operating procedures that must be followed in our pharmacy. The system we devised and implemented has proven to be effective, easy to update and maintain, very inexpensive, and user friendly. Its use has reduced the time previously required for a read-over review of standard operating procedures from 30 or 40 minutes to 5 or 10 minutes in weekly staff meetings, and we can now easily document and access proof of employees' comprehension of that content. It is our hope that other small compounding pharmacies will also find this system of online standard operating procedure review helpful.

  1. 42 CFR 422.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Procedures before the Departmental Appeals Board on review. 422.1080 Section 422.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF.... Copies of any brief or other written statement must be sent in accordance with 422.1016. ...

  2. Physical Restraint of People with Intellectual Disability: A Review of Implementation Reduction and Elimination Procedures

    ERIC Educational Resources Information Center

    Luiselli, James K.

    2009-01-01

    Background: This review describes procedures to reduce and eliminate physical restraint of people with intellectual disability. One approach is to assess antecedent conditions associated with restraint and change them so that they no longer produce restraint-provoking behaviour. A second approach is to decrease the duration of restraint by…

  3. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Procedures for issuing a decision on a registration review case. 155.58 Section 155.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... decision, the Agency will, among other things: (1) State its proposed findings with respect to the...

  4. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  5. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  6. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  7. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  8. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  9. 15 CFR Supplement No. 9 to Part 748 - End-User Review Committee Procedures

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false End-User Review Committee Procedures No. Supplement No. 9 to Part 748 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT...

  10. 77 FR 36532 - Review of Small Generator Interconnection Agreements and Procedures; Solar Energy Industries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ...-001; ER12-1855-000] Review of Small Generator Interconnection Agreements and Procedures; Solar Energy... discuss issues related to a petition for rulemaking recently submitted by the Solar Energy Industries... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal...

  11. 36 CFR 223.191 - Sourcing area disapproval and review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Sourcing area disapproval and review procedures. 223.191 Section 223.191 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER The Forest Resources...

  12. 42 CFR 422.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Procedures before the Departmental Appeals Board on review. 422.1080 Section 422.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM...

  13. 42 CFR 423.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Procedures before the Departmental Appeals Board on review. 423.1080 Section 423.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) VOLUNTARY MEDICARE PRESCRIPTION...

  14. A Qualitative Analysis of the Determinants in the Choice of a French Journal Reviewing Procedures

    ERIC Educational Resources Information Center

    Morge, Ludovic

    2015-01-01

    Between 1993 and 2010, two French journals (Aster and Didaskalia) coming from different backgrounds but belonging to the same institution used to publish papers on research in science and technology education. The merging of these journals made it necessary for them to compare the different reviewing procedures used by each. This merging occurred…

  15. Physical Restraint of People with Intellectual Disability: A Review of Implementation Reduction and Elimination Procedures

    ERIC Educational Resources Information Center

    Luiselli, James K.

    2009-01-01

    Background: This review describes procedures to reduce and eliminate physical restraint of people with intellectual disability. One approach is to assess antecedent conditions associated with restraint and change them so that they no longer produce restraint-provoking behaviour. A second approach is to decrease the duration of restraint by…

  16. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS Application of Executive Orders on Floodplain Management and Protection of Wetlands § 55.10 Environmental review procedures... 58) of proposed actions in a floodplain or wetland. (b) The categorical exclusion of certain...

  17. A Review of Procedures for Analyzing Coherence in Written Language Samples.

    ERIC Educational Resources Information Center

    Irwin, Judith Westphal

    1982-01-01

    The article presents a critical review of procedures for analyzing coherence in written language samples. The psychological model of referential coherence, linguistic analysis of cohesion, and given/new contract are discussed in terms of research results, psychometric concerns, and writing research. Recommendations concerning their relative…

  18. 47 CFR 76.945 - Procedures for Commission review of basic service rates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... service rates. 76.945 Section 76.945 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation § 76.945 Procedures for Commission review of basic service rates. (a) Upon assumption of rate regulation authority...

  19. A qualitative analysis of the determinants in the choice of a French journal reviewing procedures

    NASA Astrophysics Data System (ADS)

    Morge, Ludovic

    2015-12-01

    Between 1993 and 2010, two French journals (Aster and Didaskalia) coming from different backgrounds but belonging to the same institution used to publish papers on research in science and technology education. The merging of these journals made it necessary for them to compare the different reviewing procedures used by each. This merging occurred at a time when research is becoming increasingly international which partly determines some of the reviewing procedure choices. In order for a francophone international journal to survive, it needs to take this internationalization into account in a reasoned manner. The author of this article, as a chief editor of RDST (Recherches en Didactique des Sciences et des Technologies)—the journal resulting from the merging- taking part in this merger, analyses the social, cultural and pragmatic determinants which impacted the choices made in reviewing procedures. This paper describes how these diversity of factors leads us to drop the idea of a standard reviewing procedure which would be valid for all journals.

  20. 36 CFR 223.191 - Sourcing area disapproval and review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Sourcing area disapproval and review procedures. 223.191 Section 223.191 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS,...

  1. 36 CFR 223.191 - Sourcing area disapproval and review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Sourcing area disapproval and review procedures. 223.191 Section 223.191 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS,...

  2. 36 CFR 223.191 - Sourcing area disapproval and review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Sourcing area disapproval and review procedures. 223.191 Section 223.191 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS,...

  3. A Qualitative Analysis of the Determinants in the Choice of a French Journal Reviewing Procedures

    ERIC Educational Resources Information Center

    Morge, Ludovic

    2015-01-01

    Between 1993 and 2010, two French journals (Aster and Didaskalia) coming from different backgrounds but belonging to the same institution used to publish papers on research in science and technology education. The merging of these journals made it necessary for them to compare the different reviewing procedures used by each. This merging occurred…

  4. 34 CFR 303.342 - Procedures for IFSP development, review, and evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Procedures for IFSP development, review, and evaluation. 303.342 Section 303.342 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION...

  5. The Utility of Routine Intensive Care Admission for Patients Undergoing Intracranial Neurosurgical Procedures: A Systematic Review.

    PubMed

    de Almeida, Cesar Cimonari; Boone, M Dustin; Laviv, Yosef; Kasper, Burkhard S; Chen, Clark C; Kasper, Ekkehard M

    2017-08-14

    Patients who have undergone intracranial neurosurgical procedures have traditionally been admitted to an intensive care unit (ICU) for close postoperative neurological observation. The purpose of this study was to systematically review the evidence for routine ICU admission in patients undergoing intracranial neurosurgical procedures and to evaluate the safety of alternative postoperative pathways. We were interested in identifying studies that examined selected patients who presented for elective, non-emergent intracranial surgery whose postoperative outcomes were compared as a function of ICU versus non-ICU admission. A systematic review was performed in July 2016 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist of the Medline database. The search strategy was created based on the following key words: "craniotomy," "neurosurgical procedure," and "intensive care unit." The nine articles that satisfied the inclusion criteria yielded a total of 2227 patients. Of these patients, 879 were observed in a non-ICU setting. The most frequent diagnoses were supratentorial brain tumors, followed by patients with cerebrovascular diseases and infratentorial brain tumors. Three percent (30/879) of the patients originally assigned to floor or intermediate care status were transferred to the ICU. The most frequently observed neurological complications leading to ICU transfer were delayed postoperative neurological recovery, seizures, worsening of neurological deficits, hemiparesis, and cranial nerves deficits. Our systematic review demonstrates that routine postoperative ICU admission may not benefit carefully selected patients who have undergone elective intracranial neurosurgical procedures. In addition, limiting routine ICU admission may result in significant cost savings.

  6. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of certain...

  7. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of certain...

  8. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of certain...

  9. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of certain...

  10. 75 FR 50750 - Streamlined Procedure for Appeal Brief Review in Inter Partes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... United States Patent and Trademark Office Streamlined Procedure for Appeal Brief Review in Inter Partes... appeal briefs filed in inter partes reexamination proceeding appeals to increase the efficiency of the... determining whether appeal briefs filed in inter partes reexamination proceedings (i.e., appellant's briefs...

  11. 34 CFR 222.158 - What procedures apply to the Secretary's review of an initial decision?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What procedures apply to the Secretary's review of an initial decision? 222.158 Section 222.158 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION IMPACT AID PROGRAMS...

  12. 34 CFR 602.33 - Procedures for review of agencies during the period of recognition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Procedures for review of agencies during the period of recognition. 602.33 Section 602.33 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE SECRETARY'S RECOGNITION...

  13. 19 CFR 207.92 - Procedures for commencing review of final determinations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FAIR VALUE OR FROM SUBSIDIZED EXPORTS TO THE UNITED STATES Implementing Regulations for the North American Free Trade Agreement § 207.92 Procedures for commencing review of final determinations. (a) Notice... determinations. 207.92 Section 207.92 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE...

  14. 19 CFR 207.92 - Procedures for commencing review of final determinations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FAIR VALUE OR FROM SUBSIDIZED EXPORTS TO THE UNITED STATES Implementing Regulations for the North American Free Trade Agreement § 207.92 Procedures for commencing review of final determinations. (a) Notice... determinations. 207.92 Section 207.92 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE...

  15. 19 CFR 207.92 - Procedures for commencing review of final determinations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FAIR VALUE OR FROM SUBSIDIZED EXPORTS TO THE UNITED STATES Implementing Regulations for the North American Free Trade Agreement § 207.92 Procedures for commencing review of final determinations. (a) Notice... determinations. 207.92 Section 207.92 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE...

  16. 19 CFR 207.92 - Procedures for commencing review of final determinations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FAIR VALUE OR FROM SUBSIDIZED EXPORTS TO THE UNITED STATES Implementing Regulations for the North American Free Trade Agreement § 207.92 Procedures for commencing review of final determinations. (a) Notice... determinations. 207.92 Section 207.92 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE...

  17. 19 CFR 207.92 - Procedures for commencing review of final determinations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FAIR VALUE OR FROM SUBSIDIZED EXPORTS TO THE UNITED STATES Implementing Regulations for the North American Free Trade Agreement § 207.92 Procedures for commencing review of final determinations. (a) Notice... determinations. 207.92 Section 207.92 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE...

  18. Emergency Major Abdominal Surgical Procedures in Older Adults: A Systematic Review of Mortality and Functional Outcomes

    PubMed Central

    Cooper, Zara; Scott, John W.; Rosenthal, Ronnie A.; Mitchell, Susan L.

    2016-01-01

    OBJECTIVES To systematically review the current literature on mortality and functional outcomes after emergency major abdominal surgery in older adults. DESIGN Systematic literature search and standardized data collection of primary research publications from January 1994 through December 2013 on mortality or functional outcome in adults aged 65 and older after emergency major abdominal surgery using PubMed, EMBASE, Web of Science, Cochrane, and CINAHL. Bibliographies of relevant reports were also hand-searched to identify all potentially eligible studies. SETTING Systematic review of retrospective and cohort studies using Preferred Reporting Items for Systematic reviews and Meta-Analyses, Meta-analysis Of Observational Studies in Epidemiology, Strengthening the Reporting of Observational Studies in Epidemiology, and A Measurement Tool to Assess Systematic Reviews guidelines. PARTICIPANTS Older adults. MEASUREMENTS Articles were assessed using a standardized quality scoring system based on study design, measurement of exposures, measurement of outcomes, and control for confounding. RESULTS Of 1,459 articles screened, 93 underwent full-text review, and 20 were systematically reviewed. In-hospital and 30-day mortality of all older adults exceeded 15% in 14 of 16 studies, where reported. Older adults undergoing emergency major abdominal surgery consistently had higher mortality across study settings and procedure types than younger individuals undergoing emergency procedures and older adults undergoing elective procedures. In studies that stratified older adults, odds of death increased with age. None of these studies examined postoperative functional status, which precluded including functional outcomes in this review. Differences in exposures, outcomes, and data presented in the studies did not allow for quantification of association using metaanalysis. CONCLUSION Age independently predicts mortality after emergency major abdominal surgery. Data on changes in

  19. Correcting the relationship between PRI and shadow fraction for the blue sky effect

    NASA Astrophysics Data System (ADS)

    Mõttus, Matti

    2016-04-01

    The Photochemical Reflectance Index (PRI) is defined as the normalized difference ratio of leaf reflectance at two specific wavelengths in the green spectral region. Its value depends on the status of leaf carotenoid content, and especially that of the xanthophyll cycle pigments. Due to the dependence on the xanthophyll cycle, when the photosynthetic apparatus of green leaves is close to the saturation limit, their PRI becomes dependent on light conditions. Therefore, by measuring the PRI of leaves in the same canopy under different local irradiance conditions on a sunny day, it should be possible to determine the saturation level of the leaves. In turn, this gives information on the light use efficiency (LUE) of the vegetation canopy. The average light conditions of visible foliage elements are often quantified with the shadow fraction -- the fraction of visible foliage not lit by direct sunlight. The dependence of PRI on the shadow fraction has been used to remotely measure canopy LUE on clear days. Variations in shadow fraction have been achieved with multiangular measurement. However, besides photosynthetic downregulation, the dependence of canopy PRI on shadow fraction is affected by the blue sky radiation caused by scattering in the atmosphere. To quantify this effect on remotely sensed PRI, we present the underlying definitions relating leaf and canopy PRI and perform the required calculations for typical midsummer conditions in Central Finland. We demonstrate that the effect of blue sky radiation on the variation of PRI with canopy shadow fraction is similar in shape and magnitude to that of LUE variations reported in literature. Next, we propose a new method to assess these PRI variations in structured vegetation. We investiagate this blue sky effect on the PRI -- shadow fraction relationship with high spatial (60 cm) and spectral (9.8 nm) resolution airborne imaging spectroscopy data from Hyytiälä, Finland. We evaluate the spectral irradiance in

  20. Involvement of histidine in complex formation of PriB and single-stranded DNA.

    PubMed

    Fujiyama, Saki; Abe, Yoshito; Takenawa, Taichi; Aramaki, Takahiko; Shioi, Seijiro; Katayama, Tsutomu; Ueda, Tadashi

    2014-02-01

    PriB is a basic 10-kDa protein that acts as a facilitator in PriA-dependent replication restart in Escherichia coli. PriB has an OB-fold dimer structure and exhibits single-stranded DNA (ssDNA)-binding activities similar to single-stranded binding protein (SSB). In this study, we examined PriB's interaction with ssDNA (oligo-dT35, -dT15, and -dT7) using heteronuclear NMR analysis. Interestingly, (1)H or (15)N chemical shift changes of the PriB main-chain showed two distinct modes using oligo-dT35. The chemical shift perturbation sites in the primary mode were consistent with the main contact site in PriB-ssDNA, which was previously determined by crystal structure analysis. The results also suggested that approximately 8nt in ssDNA was the main contact site to PriB. In the secondary mode, residues in the α-helix region (His57-Ser65) and in β4-loop3-β5 were mainly perturbed. On the other hand, we examined the state of ssDNA by FRET using 5'-Cy3- and 3'-Cy5-modified oligo-dT35. As the PriB concentration increased, two-step saturation curves were observed in the FRET assay, suggesting a compact structure of ssDNA. Moreover, we confirmed two-step PriB binding to oligo-dT35 using EMSA. The pH dependence of FRET suggested contribution of the His residues. Therefore, we prepared His mutants of PriB and found that His64 in the α-helix region contributed to the second interaction between PriB and ssDNA using FRET and EMSA. Thus, from a structural standpoint, we suggested the role of His64 on the compactness of the PriB-ssDNA complex and on the positive cooperativity of PriB.

  1. Non-Parenteral Medications for Procedural Sedation in Children- A Narrative: Review Article.

    PubMed

    Fallah, Razieh; Ferdosian, Farzad; Shajari, Ahmad

    2015-01-01

    Procedural sedation may be needed in many diagnostic and therapeutic procedures in children. To make pediatric procedural sedation as safe as possible, protocols should be developed by institutions. Response to sedation in children is highly variable, while some become deeply sedated after minimal doses, others may need much higher doses. Child developmental status, clinical circumstances and condition of patient should be considered and then pharmacologic and non-pharmacologic interventions for sedation be selected. Drug of choice and administration route depend on the condition of the child, type of procedure, and predicted pain degree. The drugs might be administered parenteral (intravenous or intramuscular) or non parenteral including oral, rectal, sublingual, aerosolized buccal and intranasal. The use of intravenous medication such propofol, ketamine, dexmedetomidine, or etomidate may be restricted in use by pediatric anesthesiologist or pediatric critical care specialists or pediatric emergency medicine specialists. In this review article we discuss on non-parenteral medications that can be used by non- anesthesiologist.

  2. Non-Parenteral Medications for Procedural Sedation in Children- A Narrative: Review Article

    PubMed Central

    FALLAH, Razieh; FERDOSIAN, Farzad; SHAJARI, Ahmad

    2015-01-01

    Procedural sedation may be needed in many diagnostic and therapeutic procedures in children. To make pediatric procedural sedation as safe as possible, protocols should be developed by institutions. Response to sedation in children is highly variable, while some become deeply sedated after minimal doses, others may need much higher doses. Child developmental status, clinical circumstances and condition of patient should be considered and then pharmacologic and non-pharmacologic interventions for sedation be selected. Drug of choice and administration route depend on the condition of the child, type of procedure, and predicted pain degree. The drugs might be administered parenteral (intravenous or intramuscular) or non parenteral including oral, rectal, sublingual, aerosolized buccal and intranasal. The use of intravenous medication such propofol, ketamine, dexmedetomidine, or etomidate may be restricted in use by pediatric anesthesiologist or pediatric critical care specialists or pediatric emergency medicine specialists. In this review article we discuss on non-parenteral medications that can be used by non- anesthesiologist. PMID:26401146

  3. Using a tablet computer during pediatric procedures: a case series and review of the "apps".

    PubMed

    McQueen, Alisa; Cress, Chelsea; Tothy, Alison

    2012-07-01

    Children who require procedures and interventions that might be painful or anxiety provoking often require physical restraint, procedural sedation, or both. Nonpharmacologic distraction techniques have been shown to be a helpful adjunct in these situations and can decrease or even eliminate the need for restraint or sedation. We present a case series of children who successfully underwent painful procedures using no restraint or sedation, but rather, distraction with the Apple iPad. We are finding this device to be increasingly useful in the management of pain and anxiety in the pediatric emergency department. We review several available applications (also known as "apps") available on this device with particular attention to features that assist providers in selecting appropriate ones by age, developmental stage, and type of procedure.

  4. Effectiveness of internet-based affect induction procedures: A systematic review and meta-analysis.

    PubMed

    Ferrer, Rebecca A; Grenen, Emily G; Taber, Jennifer M

    2015-12-01

    Procedures used to induce affect in a laboratory are effective and well-validated. Given recent methodological and technological advances in Internet research, it is important to determine whether affect can be effectively induced using Internet methodology. We conducted a meta-analysis and systematic review of prior research that has used Internet-based affect induction procedures, and examined potential moderators of the effectiveness of affect induction procedures. Twenty-six studies were included in final analyses, with 89 independent effect sizes. Affect induction procedures effectively induced general positive affect, general negative affect, fear, disgust, anger, sadness, and guilt, but did not significantly induce happiness. Contamination of other nontarget affect did not appear to be a major concern. Video inductions resulted in greater effect sizes. Overall, results indicate that affect can be effectively induced in Internet studies, suggesting an important venue for the acceleration of affective science. (PsycINFO Database Record

  5. Literature Review of Cosmetic Procedures in Men: Approaches and Techniques are Gender Specific.

    PubMed

    Cohen, Brandon E; Bashey, Sameer; Wysong, Ashley

    2017-02-01

    The proportion of men receiving non-surgical cosmetic procedures has risen substantially in recent years. Various physiologic, anatomic, and motivational considerations differentiate the treatments for male and female patients. Nevertheless, research regarding approaches to the male cosmetic patient is scarce. We sought to provide an overview and sex-specific discussion of the most popular cosmetic dermatologic procedures pursued by men by conducting a comprehensive literature review pertaining to non-surgical cosmetic procedures in male patients. The most common and rapidly expanding non-surgical interventions in men include botulinum toxin, filler injection, chemical peels, microdermabrasion, laser resurfacing, laser hair removal, hair transplantation, and minimally invasive techniques for adipose tissue reduction. Important sex-specific factors associated with each of these procedures should be considered to best serve the male cosmetic patient.

  6. Welfare implications of invasive piglet husbandry procedures, methods of alleviation and alternatives: a review.

    PubMed

    Sutherland, M A

    2015-01-01

    Iron administration, teeth clipping, tail docking and castration are common invasive husbandry procedures performed on piglets on commercial farms, generally within the first week of life. These procedures are performed to prevent potential health and welfare problems of piglets and/or the sow, or, with respect to castration, to enhance meat quality. The objectives of this review were firstly, to provide the rationale and scientific evidence for performing these procedures, secondly, to describe the welfare implications of these procedures, and lastly, to describe mitigation strategies or alternatives that can be used to eliminate or reduce the pain caused by these procedures. Administering supplementary iron is necessary to prevent anaemia in piglets and the procedure has a low welfare impact. The stated benefits of teeth clipping to prevent udder lesions do not appear to outweigh the risk from injury and infection in piglets following the procedure. Tail docking reduces the prevalence of tail biting, but does not eliminate this behaviour and the practice of tail docking can cause acute pain. Castration is primarily performed to reduce the occurrence of boar taint, but alternatives are now available that negate the need to perform this procedure. Teeth clipping, tail docking and castration all cause behavioural and physiological changes indicative of acute pain and can have potentially long-term negative consequences such as causing abscesses, lesions and the formation of neuromas. Therefore effective pain mitigation strategies (e.g. analgesia, local or general anaesthesia) that markedly alleviate the pain caused by these procedures are necessary to improve the welfare of piglets. Alternatively, if management practices are available that eliminate the need for performing these procedures altogether, then they should be adopted.

  7. Efficacy and safety of repeated oral sucrose for repeated procedural pain in neonates: A systematic review.

    PubMed

    Gao, Haixia; Gao, Honglian; Xu, Guihua; Li, Mei; Du, Shizheng; Li, Fang; Zhang, Hua; Wang, Danwen

    2016-10-01

    Although sucrose is most extensively examined for its analgesia effect on a single procedural pain, neonates in neonatal intensive care units can be exposed to numerous painful procedures every day requiring multiple doses of sucrose. Some experiments have been performed to examine the efficacy and safety of repeated sucrose administration for repeated procedural pain; however, a systematic review of this topic has not yet been carried out. To identify and assess the evidence demonstrating the efficacy and safety of repeated sucrose for repeated procedural pain in neonates. A systematic review was conducted using the Cochrane methodology. Pubmed, Cochrane Library, Web of Science, CINAHL (Cumulative Index to Nursing and Allied Health Literature), CBMdisc, CNKI, VIP, and Wanfang databases were searched through December 2015. All related abstracts were reviewed and the full texts of relevant articles were studied. Randomized controlled trials (RCTs) were included. Risk of bias was assessed for RCTs using quality critical appraisal criteria recommended by Cochrane Handbook. A standardised data form was used to extract information. Eight RCTs met our inclusion criteria. Different study designs were used in the included RCTs, which did not allow us to carry out a meta-analysis. The findings from this review indicated that repeated sucrose was effective in reducing both behavioral pain response and composite pain scores during repeated procedural pain. However, as for physiological pain response, one trial found less variability in physiological pain response for term neonates in the sucrose group than the sterile water group, while two trials demonstrated repeated sucrose was inefficacious for preterm neonates. Regarding the clinical outcomes, no study reported adverse effects related to the repeated sucrose administration. Regarding the neurobehavioral development, two trials reported repeated sucrose for repeated procedural pain would not lead to poor neurologic

  8. Conceptual framework for drug usage review, medical audit and other patient care review procedures.

    PubMed

    Stolar, M H

    1977-02-01

    The following concepts are discussed: (1) quality assurance programs, (2) drug usage review, (3) utilization review, (4) peer review, (5) medical audit, (6) patient care audit and (7) medical care evaluation studies. A framework within which all types of hospital quality assurance mechanisms can be constructed is proposed and their interrelationships are described. The pharmacist's particpiation in the hospital's overall quality assurance program is stressed in two main areas-drug usage review, performed jointly with the medical staff, and quality assurance of pharmaceutical services, a peer review function of the pharmacy profession. These services are primarily drug distribution and control, drug information, clinical pharmacy, continuing education, and other pharmacy and pharmacist functions. Both functions may be viewed as parts of the pharmacy audit, one of several patient care audits within the facility. Pharmacists in skilled nursing facilities have quality assurance responsibilities similar to those of hospital-based pharmacists.

  9. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing.

    PubMed

    Auyeung, Vincent C; Ulitsky, Igor; McGeary, Sean E; Bartel, David P

    2013-02-14

    To use microRNAs to downregulate mRNA targets, cells must first process these ~22 nt RNAs from primary transcripts (pri-miRNAs). These transcripts form RNA hairpins important for processing, but additional determinants must distinguish pri-miRNAs from the many other hairpin-containing transcripts expressed in each cell. Illustrating the complexity of this recognition, we show that most Caenorhabditis elegans pri-miRNAs lack determinants required for processing in human cells. To find these determinants, we generated many variants of four human pri-miRNAs, sequenced millions that retained function, and compared them with the starting variants. Our results confirmed the importance of pairing in the stem and revealed three primary-sequence determinants, including an SRp20-binding motif (CNNC) found downstream of most pri-miRNA hairpins in bilaterian animals, but not in nematodes. Adding this and other determinants to C. elegans pri-miRNAs imparted efficient processing in human cells, thereby confirming the importance of primary-sequence determinants for distinguishing pri-miRNAs from other hairpin-containing transcripts. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing

    PubMed Central

    Auyeung, Vincent C.; Ulitsky, Igor; McGeary, Sean E.; Bartel, David P.

    2013-01-01

    SUMMARY To use microRNAs to down-regulate mRNA targets, cells must first process these ~22 nt RNAs from primary transcripts (pri-miRNAs). These transcripts form RNA hairpins important for processing, but additional determinants must distinguish pri-miRNAs from the many other hairpin-containing transcripts expressed in each cell. Illustrating the complexity of this recognition, we show that most Caenorhabditis elegans pri-miRNAs lack determinants required for processing in human cells. To find these determinants, we generated >1011 variants of four human pri-miRNAs, sequenced millions that retained function and compared them with the starting variants. Our results confirmed the importance of pairing in the stem and revealed three primary-sequence determinants, including an SRp20-binding motif (CNNC) found downstream of most pri-miRNA hairpins in bilaterian animals but not in nematodes. Adding this and other determinants to C. elegans pri-miRNAs imparted efficient processing in human cells, thereby confirming the importance of primary-sequence determinants for distinguishing pri-miRNAs from other hairpin-containing transcripts. PMID:23415231

  11. Dissemination of Periodontal Pathogens in the Bloodstream after Periodontal Procedures: A Systematic Review

    PubMed Central

    Horliana, Anna Carolina Ratto Tempestini; Chambrone, Leandro; Foz, Adriana Moura; Artese, Hilana Paula Carillo; Rabelo, Mariana de Sousa; Pannuti, Cláudio Mendes; Romito, Giuseppe Alexandre

    2014-01-01

    Background To date, there is no compilation of evidence-based information associating bacteremia and periodontal procedures. This systematic review aims to assess magnitude, duration, prevalence and nature of bacteremia caused by periodontal procedures. Study Design Systematic Review Types of Studies Reviewed MEDLINE, EMBASE and LILACS databases were searched in duplicate through August, 2013 without language restriction. Observational studies were included if blood samples were collected before, during or after periodontal procedures of patients with periodontitis. The methodological quality was assessed in duplicate using the modified Newcastle-Ottawa scale (NOS). Results Search strategy identified 509 potentially eligible articles and nine were included. Only four studies demonstrated high methodological quality, whereas five were of medium or low methodological quality. The study characteristics were considered too heterogeneous to conduct a meta-analysis. Among 219 analyzed patients, 106 (49.4%) had positive bacteremia. More frequent bacteria were S. viridans, A. actinomycetemcomitans P. gingivalis, M. micros and species Streptococcus and Actinomyces, although identification methods of microbiologic assays were different among studies. Clinical Implications Although half of the patients presented positive bacteremia after periodontal procedures, accurate results regarding the magnitude, duration and nature of bacteremia could not be confidentially assessed. PMID:24870125

  12. A systematic review of music-based interventions for procedural support.

    PubMed

    Yinger, Olivia Swedberg; Gooding, Lori F

    2015-01-01

    Individuals undergoing medical procedures frequently experience pain and anxiety. Music-based interventions have the potential to help alleviate these symptoms. This review investigated the effects of music-based interventions (music therapy and music medicine) on pain and anxiety in children and adults undergoing medical procedures. This systematic review examined randomized controlled trial music intervention studies to manage patient-reported pain and/or anxiety during medical procedures. All studies were published in English and peer-reviewed journals. Quality and risk of bias were assessed using criteria from the Checklist to Evaluate a Report of a Nonpharmacological Trial (CLEAR-NPT). Fifty studies met inclusion criteria, the majority of which (84%) had a high risk of bias. It was not possible to perform a meta-analysis because studies varied greatly in terms of medical procedure and intervention type. Results varied across studies, with approximately half (48%) indicating less anxiety for music intervention participants; fewer studies (36%) reported less pain for music intervention participants. There is a need to clearly define and differentiate between music therapy and music medicine interventions in procedural support research. Further research is necessary to determine which patients would benefit most from music interventions during medical procedures, and which interventions are most beneficial. To improve research quality and reduce risk of bias, when designing studies investigators need to carefully consider factors related to design, including randomization, treatment allocation concealment, blinding outcome assessors, and intention-to-treat analysis. In addition, more detailed intervention reporting is needed when publishing results. © the American Music Therapy Association 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. What is a Bristow-Latarjet procedure? A review of the described operative techniques and outcomes.

    PubMed

    Cowling, P D; Akhtar, M A; Liow, R Y L

    2016-09-01

    A variety of operative techniques have been described as under the term 'Bristow-Latarjet' procedure. This review aims to define the original procedure, and compare the variation in techniques described in the literature, assessing any effect on clinical outcomes. A systematic review of 24 studies was performed to compare specific steps of the technique (coracoid osteotomy site, subscapularis approach, orientation and position of coracoid graft fixation and fixation method, additional labral and capsular repair) and detect any effect this variability had on outcomes. Overall recurrence rate was 5.36% (2.94% to 43%). Half of the studies performed the procedure for recurrent shoulder instability, with only five studies documenting glenoid bone loss as an indication: 12 studies used the procedure as the primary surgical intervention for recurrent instability. No change in outcome was noted when examining variation in the coracoid osteotomy site, the fixation site on the scapular neck, the fixation method or whether a capsular repair was also performed. Performing a horizontal split in subscapularis may preserve external rotation compared with performing a tenotomy. This is the first review to examine various operative techniques of the Bristow-Latarjet procedure, and their effect on outcome. We found that other than the approach through subscapularis, outcome was independent of the surgical technique, and depended more on patient selection. We would commend future publications on this procedure to provide a detailed description of the surgical technique, and as a minimum present rates of recurrence as an outcome measure. Cite this article: Bone Joint J 2016;98-B:1208-14. ©2016 The British Editorial Society of Bone & Joint Surgery.

  14. Interventions to Improve Patient Comprehension in Informed Consent for Medical and Surgical Procedures: A Systematic Review

    PubMed Central

    Schenker, Yael; Fernandez, Alicia; Sudore, Rebecca; Schillinger, Dean

    2017-01-01

    Background Patient understanding in clinical informed consent is often poor. Little is known about the effectiveness of interventions to improve comprehension or the extent to which such interventions address different elements of understanding in informed consent. Purpose To systematically review communication interventions to improve patient comprehension in informed consent for medical and surgical procedures. Data Sources A systematic literature search of English-language articles in MEDLINE (1949–2008) and EMBASE (1974–2008) was performed. In addition, a published bibliography of empirical research on informed consent and the reference lists of all eligible studies were reviewed. Study Selection Randomized controlled trials and controlled trials with non-random allocation were included if they compared comprehension in informed consent for a medical or surgical procedure. Only studies that used a quantitative, objective measure of understanding were included. All studies addressed informed consent for a needed or recommended procedure in actual patients. Data Extraction Reviewers independently extracted data using a standardized form. All results were compared, and disagreements were resolved by consensus. Data Synthesis Forty-four studies were eligible. Intervention categories included written information, audiovisual/multimedia, extended discussions, and test/feedback techniques. The majority of studies assessed patient understanding of procedural risks; other elements included benefits, alternatives, and general knowledge about the procedure. Only 6 of 44 studies assessed all 4 elements of understanding. Interventions were generally effective in improving patient comprehension, especially regarding risks and general knowledge. Limitations Many studies failed to include adequate description of the study population, and outcome measures varied widely. Conclusions A wide range of communication interventions improve comprehension in clinical informed

  15. Monitoring seasonal and diurnal changes in photosynthetic pigments with automated PRI and NDVI sensors

    NASA Astrophysics Data System (ADS)

    Gamon, J. A.; Kovalchuck, O.; Wong, C. Y. S.; Harris, A.; Garrity, S. R.

    2015-07-01

    The vegetation indices normalized difference vegetation index (NDVI) and photochemical reflectance index (PRI) provide indicators of pigmentation and photosynthetic activity that can be used to model photosynthesis from remote sensing with the light-use-efficiency model. To help develop and validate this approach, reliable proximal NDVI and PRI sensors have been needed. We tested new NDVI and PRI sensors, "spectral reflectance sensors" (SRS sensors; recently developed by Decagon Devices, during spring activation of photosynthetic activity in evergreen and deciduous stands. We also evaluated two methods of sensor cross-calibration - one that considered sky conditions (cloud cover) at midday only, and another that also considered diurnal sun angle effects. Cross-calibration clearly affected sensor agreement with independent measurements, with the best method dependent upon the study aim and time frame (seasonal vs. diurnal). The seasonal patterns of NDVI and PRI differed for evergreen and deciduous species, demonstrating the complementary nature of these two indices. Over the spring season, PRI was most strongly influenced by changing chlorophyll : carotenoid pool sizes, while over the diurnal timescale, PRI was most affected by the xanthophyll cycle epoxidation state. This finding demonstrates that the SRS PRI sensors can resolve different processes affecting PRI over different timescales. The advent of small, inexpensive, automated PRI and NDVI sensors offers new ways to explore environmental and physiological constraints on photosynthesis, and may be particularly well suited for use at flux tower sites. Wider application of automated sensors could lead to improved integration of flux and remote sensing approaches for studying photosynthetic carbon uptake, and could help define the concept of contrasting vegetation optical types.

  16. Monitoring seasonal and diurnal changes in photosynthetic pigments with automated PRI and NDVI sensors

    NASA Astrophysics Data System (ADS)

    Gamon, J. A.; Kovalchuk, O.; Wong, C. Y. S.; Harris, A.; Garrity, S. R.

    2015-02-01

    The vegetation indices normalized difference vegetation index (NDVI) and photochemical reflectance index (PRI) provide indicators of pigmentation and photosynthetic activity that can be used to model photosynthesis from remote sensing with the light-use efficiency model. To help develop and validate this approach, reliable proximal NDVI and PRI sensors have been needed. We tested new NDVI and PRI sensors, "SRS" sensors recently developed by Decagon Devices, during spring activation of photosynthetic activity in evergreen and deciduous stands. We also evaluated two methods of sensor cross-calibration, one that considered sky conditions (cloud cover) at midday only, and the other that also considered diurnal sun angle effects. Cross-calibration clearly affected sensor agreement with independent measurements, with the best method dependent upon the study aim and time frame (seasonal vs. diurnal). The seasonal patterns of NDVI and PRI differed for evergreen and deciduous species, demonstrating the complementary nature of these two indices. Over the spring season, PRI was most strongly influenced by changing chlorophyll : carotenoid pool sizes, while over the diurnal time scale PRI was most affected by the xanthophyll cycle epoxidation state. This finding demonstrates that the SRS PRI sensors can resolve different processes affecting PRI over different time scales. The advent of small, inexpensive, automated PRI and NDVI sensors offers new ways to explore environmental and physiological constraints on photosynthesis, and may be particularly well-suited for use at flux tower sites. Wider application of automated sensors could lead to improved integration of flux and remote sensing approaches to studying photosynthetic carbon uptake, and could help define the concept of contrasting vegetation optical types.

  17. Informed consent procedures with cognitively impaired patients: A review of ethics and best practices.

    PubMed

    Fields, Lindy Marie; Calvert, James Douglas

    2015-08-01

    The objectives of this article are to discuss ethical issues of informed consent in cognitively impaired patients and review considerations for capacity determination. We will also discuss how to evaluate capacity, determine competence, and obtain informed consent when a patient is deemed incompetent. This review emphasizes how to carry out informed consent procedures when capacity is questionable and discusses measures supported for use when determining cognitively impaired patients' ability to consent. Information was gathered from medical and psychological codes of ethics, peer-reviewed journals, published guidelines from health-care organizations (e.g., American Medical Association), and scholarly books. Google Scholar and PsycINFO were searched for articles related to 'informed consent' and 'cognitive impairment' published in English between 1975 and 2014. Relevant sources referenced in retrieved publications were subsequently searched and reviewed. We selected 49 sources generated by our search. Sources were included in our review if they presented information related to at least one of our focus areas. These areas included: review of informed consent ethics and procedures, review of cognitive impairment evaluations, recommendations for measuring cognitive capacity, and alternative forms of informed consent. Patients' cognitive impairments can hinder the ability of patients to understand treatment options. Evaluating the capacity of patients with cognitive impairment to understand treatment options is vital for valid informed consent and should be guided by best practices. Thus, proper identification of patients with questionable capacity, capacity evaluation, and determination of competence, as well as reliance upon appropriate alternative consent procedures, are paramount. © 2015 The Authors. Psychiatry and Clinical Neurosciences © 2015 Japanese Society of Psychiatry and Neurology.

  18. Review of enucleation methods and procedures used in animal cloning: state of the art.

    PubMed

    Li, Guang-Peng; White, Kenneth L; Bunch, Thomas D

    2004-01-01

    Enucleation of a recipient oocyte is a crucially important process for nuclear transfer efficiency. Several procedures have been developed and used in the production of nuclear transfer embryos. Although the use of excitable fluorochromes and ultraviolet (UV) light are commonly used for complete enucleation, they also pose the risk of damaging the maternal cytoplast. Telophase and chemically assisted enucleation have also been used for cloning, but the quality and quantity of the recipient cytoplasm varies with the procedure used. This paper reviews various methods used for enucleation, and discusses their benefits and limitations with respect to cloning efficiency.

  19. Regulation of pri-miRNA processing by the hnRNP-like protein AtGRP7 in Arabidopsis

    PubMed Central

    Köster, Tino; Meyer, Katja; Weinholdt, Claus; Smith, Lisa M.; Lummer, Martina; Speth, Corinna; Grosse, Ivo; Weigel, Detlef; Staiger, Dorothee

    2014-01-01

    The hnRNP-like glycine-rich RNA-binding protein AtGRP7 regulates pre-mRNA splicing in Arabidopsis. Here we used small RNA-seq to show that AtGRP7 also affects the miRNA inventory. AtGRP7 overexpression caused a significant reduction in the level of 30 miRNAs and an increase for 14 miRNAs with a minimum log2 fold change of ±0.5. Overaccumulation of several pri-miRNAs including pri-miR398b, pri-miR398c, pri-miR172b, pri-miR159a and pri-miR390 at the expense of the mature miRNAs suggested that AtGRP7 affects pri-miRNA processing. Indeed, RNA immunoprecipitation revealed that AtGRP7 interacts with these pri-miRNAs in vivo. Mutation of an arginine in the RNA recognition motif abrogated in vivo binding and the effect on miRNA and pri-miRNA levels, indicating that AtGRP7 inhibits processing of these pri-miRNAs by direct binding. In contrast, pri-miRNAs of selected miRNAs that were elevated or not changed in response to high AtGRP7 levels were not bound in vivo. Reduced accumulation of miR390, an initiator of trans-acting small interfering RNA (ta-siRNA) formation, also led to lower TAS3 ta-siRNA levels and increased mRNA expression of the target AUXIN RESPONSE FACTOR4. Furthermore, AtGRP7 affected splicing of pri-miR172b and pri-miR162a. Thus, AtGRP7 is an hnRNP-like protein with a role in processing of pri-miRNAs in addition to its role in pre-mRNA splicing. PMID:25104024

  20. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... review process to evaluate applications? 75.224 Section 75.224 Education Office of the Secretary... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review applications...

  1. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... review process to evaluate applications? 75.224 Section 75.224 Education Office of the Secretary... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review applications...

  2. Surgery for constipation: systematic review and practice recommendations: Results III: Rectal wall excisional procedures (Rectal Excision).

    PubMed

    Mercer-Jones, M; Grossi, U; Pares, D; Vollebregt, P F; Mason, J; Knowles, C H

    2017-09-01

    To assess the outcomes of rectal excisional procedures in adults with chronic constipation. Standardised methods and reporting of benefits and harms were used for all CapaCiTY reviews that closely adhered to PRISMA 2016 guidance. Main conclusions were presented as summary evidence statements with a summative Oxford Centre for Evidence-Based Medicine (2009) level. Forty-seven studies were identified, providing data on outcomes in 8340 patients. Average length of procedures was 44 min and length of stay (LOS) was 3 days. There was inadequate evidence to determine variations in procedural duration or LOS by type of procedure. Overall morbidity rate was 16.9% (0-61%), with lower rates observed after Contour Transtar procedure (8.9%). No mortality was reported after any procedures in a total of 5896 patients. Although inconsistently reported, good or satisfactory outcome occurred in 73-80% of patients; a reduction of 53-91% in Longo scoring system for obstructive defecation syndrome (ODS) occurred in about 68-76% of patients. The most common long-term adverse outcome is faecal urgency, typically occurring in up to 10% of patients. Recurrent prolapse occurred in 4.3% of patients. Patients with at least 3 ODS symptoms together with a rectocoele with or without an intussusception, who have failed conservative management, may benefit from a rectal excisional procedure. Rectal excisional procedures are safe with little major morbidity. It is not possible to advise which excisional technique is superior from the point of view of efficacy, peri-operative variables, or harms. Future study is required. © 2017 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland.

  3. 7 CFR 1c.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... an expedited review procedure shall adopt a method for keeping all members advised of research... research involving no more than minimal risk, and for minor changes in approved research. 1c.110 Section 1c... review procedures for certain kinds of research involving no more than minimal risk, and for minor...

  4. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... review procedure shall adopt a method for keeping all members advised of research proposals which have... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section 46... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures...

  5. Is acupuncturing effective in controlling the gag reflex during dental procedures? A review of literature

    PubMed Central

    Daneshkazemi, Alireza; Daneshkazemi, Pedram; Davoudi, Amin; Badrian, Hamid; Firouzabadi, Vahid Pourtalebi

    2016-01-01

    Traditional acupuncture has been introduced more than 2500 years ago which provides an alternative and complementary option during clinical practices. Its main mechanism is based on stimulating the nerves by altering the processes and perception of pain transmitters. It facilitates releasing natural pain relievers such as endorphins and serotonin. Its success for various dental procedures has been proved earlier. However, its effects on controlling the gag reflex seem to be overlooked. The gag reflex is recognized as a protective reaction for stopping the entrance of any foreign bodies into the oropharynx. Pronounced gag reflexes can have negative impacts on the quality of dental procedures. Many techniques have been suggested for managing this reflex and acupuncturing is one of those which seems to be overlooked recently. The aim of this paper is reviewing the published high-quality researches about the efficacy of this technique for eliminating the gag reflex during dental procedures. PMID:27212742

  6. Implicit memory in Korsakoff's syndrome: a review of procedural learning and priming studies.

    PubMed

    Hayes, Scott M; Fortier, Catherine B; Levine, Andrea; Milberg, William P; McGlinchey, Regina

    2012-06-01

    Korsakoff's syndrome (KS) is characterized by dense anterograde amnesia resulting from damage to the diencephalon region, typically resulting from chronic alcohol abuse and thiamine deficiency. This review assesses the integrity of the implicit memory system in KS, focusing on studies of procedural learning and priming. KS patients are impaired on several measures of procedural memory, most likely due to impairment in cognitive functions associated with alcohol-related neural damage outside of the diencephalon. The pattern of performance on tasks of implicit priming suggests reliance on a residual, non-flexible memory operating more or less in an automatic fashion. Our review concludes that whether measures of implicit memory reveal intact or impaired performance in individuals with KS depends heavily on specific task parameters and demands, including timing between stimuli, the specific nature of the stimuli used in a task, and the integrity of supportive cognitive functions necessary for performance.

  7. Anesthesia for Advanced Bronchoscopic Procedures: State-of-the-Art Review.

    PubMed

    Goudra, Basavana G; Singh, Preet Mohinder; Borle, Anuradha; Farid, Nahla; Harris, Kassem

    2015-08-01

    The bronchoscopic procedures have seen a remarkable increase in both numbers and complexity. Although many anesthesia providers have kept pace with the challenge, the practice is varied and frequently suboptimal. Shared airway during bronchoscopy poses unique challenges. The available reviews have tried to address this lacuna; however, these have frequently dealt with the technical aspects of bronchoscopy than anesthetic challenges. The present review provides evidence-based management insights into anesthesia for bronchoscopy-both flexible and rigid. A systematic approach toward pre-procedural evaluation and risk stratification is presented. The possible anatomical and physiological factors that can influence the outcomes are discussed. Pharmacological principles guiding sedation levels and appropriate selection of sedatives form the crux of safe anesthetic management. The newer and safer drugs that can have potential role in anesthesia for bronchoscopy in the near future are discussed. Ventilatory strategies during bronchoscopy for prevention of hypoxia and hypercarbia are emphasized.

  8. Implicit Memory in Korsakoff’s Syndrome: A Review of Procedural Learning and Priming Studies

    PubMed Central

    Hayes, Scott M.; Fortier, Catherine B.; Levine, Andrea; Milberg, William P.; McGlinchey, Regina

    2013-01-01

    Korsakoff’s syndrome (KS) is characterized by dense anterograde amnesia resulting from damage to the diencephalon region, typically resulting from chronic alcohol abuse and thiamine deficiency. This review assesses the integrity of the implicit memory system in KS, focusing on studies of procedural learning and priming. KS patients are impaired on several measures of procedural memory, most likely due to impairment in cognitive functions associated with alcohol-related neural damage outside of the diencephalon. The pattern of performance on tasks of implicit priming suggests reliance on a residual, non-flexible memory operating more or less in an automatic fashion. Our review concludes that whether measures of implicit memory reveal intact or impaired performance in individuals with KS depends heavily on specific task parameters and demands, including timing between stimuli, the specific nature of the stimuli used in a task, and the integrity of supportive cognitive functions necessary for performance. PMID:22592661

  9. Anxiety and pain in children undergoing elective surgical procedures: a systematic review.

    PubMed

    Jia Shermin, Chieng Ying; Sally, Chan Wai-Chi; Hong-Gu, He

    2012-01-01

    Anxiety and pain are two significant problems experienced by children undergoing elective surgical procedures, which may lead to suboptimal postoperative outcomes. Previous studies have shown a correlation between perioperative anxiety and pain in children. This review aimed to present the best available evidence on the correlation between perioperative anxiety and pain in children undergoing elective surgical procedures, and to determine the relationship between children's demographics, their anxiety and pain level in the perioperative period. Participants were children aged between five to 18 years old who were scheduled for an elective surgical procedure in the hospital setting.No specific intervention was of interest. So long as the primary studies examined correlation of children's anxiety and pain in the perioperative period, they were considered for inclusion.This review focused on children's preoperative level of anxiety; children's postoperative level of anxiety; children's postoperative pain intensity; and/or children's postoperative behavioural changes.This review included quantitative research studies, such as randomised-controlled trials, cohort studies, and descriptive studies which addressed the correlation between perioperative anxiety and perioperative pain in children undergoing elective surgical procedures. A three-step search strategy was utilised in this review. The following databases were searched for articles published in English from the inception date of databases to December 2010: CINAHL, PubMed, Scopus, PsycINFO, Mednar, Trip Database, ProQuest Dissertations and Theses, Scirus ETD and Web of Science. Papers selected for retrieval were assessed independently by two reviewers for methodological quality prior to inclusion in the review using standardised critical appraisal tools from Joanna Briggs Institute. There were no disagreements between the two reviewers, so the third reviewer was not required. Data were extracted using the

  10. MS Peterson eats while reviewing procedures with Commander Weitz on middeck

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Mission Specialist (MS) Peterson, holding food container, eats while reviewing procedures with Commander Weitz (wearing bifocals) on middeck in front of starboard wall. Weitz points out an item in the frew activity plan (CAP) to Peterson as the mission specialist uses a spoon to eat a meal aboard the Earth-orbiting Challenger, Orbiter Vehicle (OV) 099. Weitz and Peterson are wearing the shirt and trouser portions of the light blue cotton multi-piece constant wear garments.

  11. Use of prophylactic antibiotic therapy in oral surgical procedures: a critical review.

    PubMed

    Guerrero, Jaime Santiago

    2008-12-01

    Despite myriad evidence-based data on the efficacy of prophylactic antibiotics in oral surgical procedures, their inaccurate use and indiscriminate abuse still continues in all clinical settings. Although controversy remains, clear-cut guidelines relying on established scientific principles do exist and must be followed. This paper provides a critical and systematic review of each principle and encourages practitioners fit to what current evidence demands.

  12. A Review of CAM for Procedural Pain in Infancy: Part II. Other Interventions

    PubMed Central

    Evans, Subhadra; Meldrum, Marcia; Altman, Tamara; Zeltzer, Lonnie K.

    2008-01-01

    This article is the second in a two-part series reviewing the empirical evidence for complementary and alternative medicine (CAM) approaches for the management of pain related to medical procedures in infants up to 6 weeks of age. Part I of this series investigated the effects of sucrose with or without non-nutritive sucking (NNS). The present article examines other CAM interventions for procedural pain including music-based interventions, olfactory stimulation, kangaroo care and swaddling. Computerized databases were searched for relevant studies including prior reviews and primary trials. Preliminary support was revealed for the analgesic effects of the CAM modalities reviewed. However, the overall quality of the evidence for these approaches remains relatively weak. Additional well-designed trials incorporating rigorous methodology are required. Such investigations will assist in the development of evidence-based guidelines on the use of CAM interventions either alone or in concert with conventional approaches to provide safe, reliable analgesia for infant procedural pain. PMID:18955254

  13. REVIEW Of COMPUTERIZED PROCEDURE GUIDELINES FOR NUCLEAR POWER PLANT CONTROL ROOMS

    SciTech Connect

    David I Gertman; Katya Le Blanc; Ronald L Boring

    2011-09-01

    Computerized procedures (CPs) are recognized as an emerging alternative to paper-based procedures for supporting control room operators in nuclear power plants undergoing life extension and in the concept of operations for advanced reactor designs. CPs potentially reduce operator workload, yield increases in efficiency, and provide for greater resilience. Yet, CPs may also adversely impact human and plant performance if not designed and implemented properly. Therefore, it is important to ensure that existing guidance is sufficient to provide for proper implementation and monitoring of CPs. In this paper, human performance issues were identified based on a review of the behavioral science literature, research on computerized procedures in nuclear and other industries, and a review of industry experience with CPs. The review of human performance issues led to the identification of a number of technical gaps in available guidance sources. To address some of the gaps, we developed 13 supplemental guidelines to support design and safety. This paper presents these guidelines and the case for further research.

  14. Report: EPA’s Review of Applications for a Water Research Grant Did Not Follow All Review Procedures and Lacked Transparency

    EPA Pesticide Factsheets

    Report #12-P-0864, September 25, 2012. NCER did not follow all applicable policies and procedures in reviewing applications submitted under RFA EPA-G2009-STAR-F1, and lacked procedures for a key aspect of its STAR grant application peer review process.

  15. Pri peptides are mediators of ecdysone for the temporal control of development.

    PubMed

    Chanut-Delalande, Hélène; Hashimoto, Yoshiko; Pelissier-Monier, Anne; Spokony, Rebecca; Dib, Azza; Kondo, Takefumi; Bohère, Jérôme; Niimi, Kaori; Latapie, Yvan; Inagaki, Sachi; Dubois, Laurence; Valenti, Philippe; Polesello, Cédric; Kobayashi, Satoru; Moussian, Bernard; White, Kevin P; Plaza, Serge; Kageyama, Yuji; Payre, François

    2014-11-01

    Animal development fundamentally relies on the precise control, in space and time, of genome expression. Whereas we have a wealth of information about spatial patterning, the mechanisms underlying temporal control remain poorly understood. Here we show that Pri peptides, encoded by small open reading frames, are direct mediators of the steroid hormone ecdysone for the timing of developmental programs in Drosophila. We identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development, through post-translational control of the Shavenbaby transcription factor. We show that manipulating pri expression is sufficient to either put on hold or induce premature differentiation of trichomes. Furthermore, we find that ecdysone-dependent regulation of pri is not restricted to epidermis and occurs over various tissues and times. Together, these findings provide a molecular framework to explain how systemic hormonal control coordinates specific programs of differentiation with developmental timing.

  16. Effect of nitrogen stress on relationship of PRI and LUE during winter wheat growth period

    NASA Astrophysics Data System (ADS)

    Guo, Jianmao; Gao, Yanghua; Wang, Qian; Fei, Dunyue; Liu, Junwei

    2014-11-01

    Light use efficiency (LUE ) is an important parameter for GPP and and NPP estimation model, cause by the existing model method to estimate the actual LUE is always simple and rough, which may lead to serious bias by GPP and NPP. The photochemical reflectance index ( PRI ) has great potential for direct estimation the actual LUE. In this paper, wheat in different nitrogen treatments was designed in field trial during Wheat growing period, for obtain photosynthesis and reflective hyperspectral data, and then LUE and PRI was calculated in critical period of wheat growth. The results show that, at different growth stages under three different nitrogen conditions, LUE and PRI value were significantly increased with increasing nitrogen absorption; Last longer, more capable of absorbing nitrogen amount, the correlation between LUE and PRI was better - for example, the correlation coefficient is obviously larger in heading stage than elongation stage for same nitrogen treatment.

  17. Microprocessor dynamics shows co- and post-transcriptional processing of pri-miRNAs

    PubMed Central

    Louloupi, Annita; Ntini, Evgenia; Liz, Julia; Ørom, Ulf Andersson

    2017-01-01

    miRNAs are small regulatory RNAs involved in the regulation of translation of target transcripts. miRNA biogenesis is a multistep process starting with the cleavage of the primary miRNA transcript in the nucleus by the Microprocessor complex. Endogenous processing of pri-miRNAs is challenging to study and the in vivo kinetics of this process is not known. Here, we present a method for determining the processing kinetics of pri-miRNAs within intact cells over time, using a pulse-chase approach to label transcribed RNA during 15 min, and follow the processing within a 1-hour window after labeling with bromouridine. We show that pri-miRNAs exhibit different processing kinetics ranging from fast over intermediate to slow processing, and we provide evidence that pri-miRNA processing can occur both cotranscriptionally and post-transcriptionally. PMID:28250203

  18. Microprocessor dynamics shows co- and post-transcriptional processing of pri-miRNAs.

    PubMed

    Louloupi, Annita; Ntini, Evgenia; Liz, Julia; Ørom, Ulf Andersson

    2017-03-01

    miRNAs are small regulatory RNAs involved in the regulation of translation of target transcripts. miRNA biogenesis is a multi-step process starting with the cleavage of the primary miRNA transcript in the nucleus by the Microprocessor complex. Endogenous processing of pri-miRNAs is challenging to study and the in vivo kinetics of this process is not known. Here, we present a method for determining the processing kinetics of pri-miRNAs within intact cells over time using a pulse-chase approach to label transcribed RNA during 15 minutes and follow the processing within a 1-hour window after labeling with bromouridine. We show, that pri-miRNAs exhibit different processing kinetics ranging from fast over intermediate to slow processing and provide evidence that pri-miRNA processing can occur both co-transcriptionally and post-transcriptionally.

  19. Corticotomies as a surgical procedure to accelerate tooth movement during orthodontic treatment: A systematic review

    PubMed Central

    Fernández-Ferrer, Laura; Montiel-Company, José-María; Candel-Martí, Eugenia; Almerich-Silla, José-Manuel; Peñarrocha-Diago, Miguel

    2016-01-01

    Background One of the main aims of orthodontists is to reduce the treatment time as much as possible, particularly in view of the rise in demand for orthodontic treatment among adult patients. The objective of this systematic review was to examine the effectiveness of corticotomy as a surgical procedure that accelerates orthodontic tooth movement, together with its possible adverse effects. Material and Methods A systematic review of articles in 4 databases, Pubmed, Cochrane, Scopus and Embase, complemented by a manual search, identified 772 articles. The duplicates were eliminated and a critical reading of titles and abstracts led to the rejection of articles that did not meet the objectives of the review, leaving 69. After reading the full text of these articles, 49 were excluded because they did not meet the inclusion criteria. On applying the CONSORT criteria as a quality filter, a further 4 were eliminated due to low quality. Finally, 16 articles (4 systematic reviews and 12 controlled trials) were reviewed. Results All the studies agree that corticotomy prior to orthodontic treatment accelerates dental movement, reducing the treatment time. With regard to side-effects, no periodontal damage was found, although this was only studied in the short term. Conclusions The evidence regarding the results of corticotomy is limited, given the small number of quality clinical studies available. Before this procedure is included as a routine practice in dental surgeries, studies of higher methodological quality are required, studying a greater number of individuals and examining the possible long-term adverse effects and the cost/benefit of the procedure. Key words:Corticotomy, orthodontics, adults, accelerated tooth movement, osteotomy. PMID:27475698

  20. Pain relief following thoracic surgical procedures: A literature review of the uncommon techniques.

    PubMed

    Alzahrani, Tariq

    2017-01-01

    Thoracic surgical procedures can be either thoracotomy or thoracoscopy. In thoracotomy, the incision could be either muscle-cutting or muscle-sparing incision. The posterolateral thoracotomy incision is used for most general thoracic surgical procedures. This incision, which involves division of the latissimus dorsi and serratus anterior muscles, affords excellent exposure of the thoracic cavity. However, it is associated with significant morbidity, including impaired pulmonary function, postoperative chest pain, and restricted arm and shoulder movement. Various muscle-sparing incisions have been proposed to decrease the morbidity. Postthoracotomy pain originates from pleural and muscular damage, costovertebral joint disruption, and intercostal nerve damage during surgery. Inadequate pain relief after surgery affects the quality of patient's recovery and exposes the patients to postoperative morbidities. There is a tendency nowadays among thoracic surgeons and anesthesiologists toward the area of enhanced recovery after thoracic surgery which requires careful titration of the anesthetic drugs in awake patients undergoing thoracoscopic procedures. There is a common feeling among thoracic anesthesiologists that potthoracoscopy procedures produce less pain intensity versus thoracotomy which is partially true. However, effective management of acute pain following either thoracotomy/thoracoscopy is needed and may prevent these complications and reduce the likelihood of developing chronic pain. In this report, we are going to review the newly introduced postthoracotomy/thoracoscopy pain relief modalities with special reference to the new tendency of awake thoracic surgical procedures and its impact on enhanced recovery after surgery.

  1. Pain relief following thoracic surgical procedures: A literature review of the uncommon techniques

    PubMed Central

    Alzahrani, Tariq

    2017-01-01

    Thoracic surgical procedures can be either thoracotomy or thoracoscopy. In thoracotomy, the incision could be either muscle-cutting or muscle-sparing incision. The posterolateral thoracotomy incision is used for most general thoracic surgical procedures. This incision, which involves division of the latissimus dorsi and serratus anterior muscles, affords excellent exposure of the thoracic cavity. However, it is associated with significant morbidity, including impaired pulmonary function, postoperative chest pain, and restricted arm and shoulder movement. Various muscle-sparing incisions have been proposed to decrease the morbidity. Postthoracotomy pain originates from pleural and muscular damage, costovertebral joint disruption, and intercostal nerve damage during surgery. Inadequate pain relief after surgery affects the quality of patient's recovery and exposes the patients to postoperative morbidities. There is a tendency nowadays among thoracic surgeons and anesthesiologists toward the area of enhanced recovery after thoracic surgery which requires careful titration of the anesthetic drugs in awake patients undergoing thoracoscopic procedures. There is a common feeling among thoracic anesthesiologists that potthoracoscopy procedures produce less pain intensity versus thoracotomy which is partially true. However, effective management of acute pain following either thoracotomy/thoracoscopy is needed and may prevent these complications and reduce the likelihood of developing chronic pain. In this report, we are going to review the newly introduced postthoracotomy/thoracoscopy pain relief modalities with special reference to the new tendency of awake thoracic surgical procedures and its impact on enhanced recovery after surgery. PMID:28757835

  2. Review of Test Procedure for Determining HSPFs of Residential Variable-Speed Heat Pumps

    SciTech Connect

    Rice, C. Keith; Munk, Jeffrey D.; Shrestha, Som S.

    2015-08-01

    This report reviews the suitability of the existing Heating Seasonal Performance Factor (HSPF) ratings and testing requirements for the current generation of variable-speed (VS) air-source heat pumps. Recent field test results indicate larger discrepancies between rated HSPF and field-observed HSPF for VS models than for single-speed models in the same houses. These findings suggest that the heating season test and ratings procedure should be revisited for VS heat pumps. The ratings and testing procedures are described in ANSI/AHRI 210/240 (2008) for single-speed, two-capacity, and variable-speed units. Analysis of manufacturer and independent test performance data on VS units reveals why the current VS testing/ratings procedure results in overly optimistic HSPF ratings for some VS units relative to other types of heat pumps. This is due to a combination of extrapolation of low speed test data beyond the originally anticipated ambient temperature operating range and the constraints of unit controls, which prevent low speed operation over the range of ambient temperatures assumed in the procedure for low speed. As a result, the HSPFs of such units are being overpredicted relative to those for single- and two-capacity designs. This overprediction has been found to be significantly reduced by use in the HSPF ratings procedure of an alternative higher-load heating load line, described in a companion report (Rice et al., 2015).

  3. The effect of economic downturn on the volume of surgical procedures: A systematic review.

    PubMed

    Fujihara, Nasa; Lark, Meghan E; Fujihara, Yuki; Chung, Kevin C

    2017-08-01

    Economic downturn can have a wide range of effects on medicine at both individual and national levels. We aim to describe these effects in relation to surgical volume to guide future planning for physician specialization, patient expectations in the face of economic crises, or estimating healthcare expenditure. We hypothesized that because of high out-of-pocket costs, cosmetic procedure volumes would be most affected by economic decline. A systematic review was conducted using MEDLINE, Embase, and ABI/INFORMS. The main search terms were "economic recession" and "surgical procedures, operative". Studies were included if surgical volumes were measured and economic indicators were used as predictors of economic conditions. Twelve studies were included, and the most common subject was cosmetic (n = 5), followed by orthopedic (n = 2) and cardiac surgeries (n = 2). The majority of studies found that in periods of economic downturn, surgical volume decreased. Among the eight studies using Pearson's correlation analysis, there were no significant differences between cosmetic procedures and other elective procedures, indicating that cosmetic procedures may display trends similar to those of non-cosmetic elective procedures in periods of economic downturn. Surgical volume generally decreased when economic indicators declined, observed for both elective and non-elective surgery fields. However, a few specific procedure volumes such as vasectomy and caesarean section for male babies increased during the economic downturn. Knowledge of these trends can be useful for future surgical planning and distribution of healthcare resources. Copyright © 2017 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

  4. Biomechanical Results of Lateral Extra-articular Tenodesis Procedures of the Knee: A Systematic Review.

    PubMed

    Slette, Erik L; Mikula, Jacob D; Schon, Jason M; Marchetti, Daniel C; Kheir, Matthew M; Turnbull, Travis Lee; LaPrade, Robert F

    2016-12-01

    To systematically review and compare biomechanical results of lateral extra-articular tenodesis (LET) procedures. A systematic review was performed using the PubMed, Medline, Embase, and Cochrane databases. The search terms included the following: extraarticular, anterolateral, iliotibial, tenodesis, plasty, augmentation, procedure, reconstruction, technique, biomechanics, kinematic, robot, cadaver, knee, lateral tenodesis, ACL, Marcacci, Lemaire, Losee, Macintosh, Ellison, Andrews, Hughston, and Muller. The inclusion criteria were nonanatomic, in vitro biomechanical studies, defined as in vitro investigations of joint motion resulting from controlled, applied forces. Of the 10 included studies, 7 analyzed anterior tibial translation and reported that isolated LET procedures did not restore normal anterior stability to the anterior cruciate ligament (ACL)-deficient knee. Seven of the 8 studies analyzing tibial rotation reported a reduction in internal tibial rotation across various flexion angles in the ACL-deficient knee when compared with the native state. Five studies reported a reduction in intra-articular graft force with the addition of an LET. Two studies evaluated length change patterns, graft course, and total strain range and found that reconstruction techniques in which the graft attached proximal to the lateral epicondyle and coursed deep to the fibular collateral ligament were most isometric. In the ACL-deficient knee, LET procedures overconstrained the knee and restricted internal tibial rotation when compared with the native state. In addition, isolated LET procedures did not return normal anterior stability to the ACL-deficient knee but did significantly reduce anterior tibial translation and intra-articular graft forces during anteriorly directed loading. Combined injury to the ACL and anterolateral structures has been reported to exhibit greater anterolateral rotatory instability when compared with isolated ACL injuries. Despite the reported

  5. mirEX: a platform for comparative exploration of plant pri-miRNA expression data.

    PubMed

    Bielewicz, Dawid; Dolata, Jakub; Zielezinski, Andrzej; Alaba, Sylwia; Szarzynska, Bogna; Szczesniak, Michal W; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia; Karlowski, Wojciech M

    2012-01-01

    mirEX is a comprehensive platform for comparative analysis of primary microRNA expression data. RT-qPCR-based gene expression profiles are stored in a universal and expandable database scheme and wrapped by an intuitive user-friendly interface. A new way of accessing gene expression data in mirEX includes a simple mouse operated querying system and dynamic graphs for data mining analyses. In contrast to other publicly available databases, the mirEX interface allows a simultaneous comparison of expression levels between various microRNA genes in diverse organs and developmental stages. Currently, mirEX integrates information about the expression profile of 190 Arabidopsis thaliana pri-miRNAs in seven different developmental stages: seeds, seedlings and various organs of mature plants. Additionally, by providing RNA structural models, publicly available deep sequencing results, experimental procedure details and careful selection of auxiliary data in the form of web links, mirEX can function as a one-stop solution for Arabidopsis microRNA information. A web-based mirEX interface can be accessed at http://bioinfo.amu.edu.pl/mirex.

  6. Relationship between PRI-MODIS and LUE in a Mediterranean deciduous forest under water stress condition

    NASA Astrophysics Data System (ADS)

    Guarini, Rocchina; Loizzo, Rosa; Nichol, Caroline J.; Borghetti, Marco

    2010-05-01

    In this study the relationship between ecosystem-level light-use efficiency (LUE) obtained from eddy covariance data and MODIS-derived values of PRI (Photochemical Reflectance Index) for a Mediterranean Quercus cerris L. forest site (Roccarespampani, Viterbo , Italy) in two different years was investigated. The years considered are contrasting in temperature and rainfall conditions (i.e. 2003, dry, and 2004, wet). The PRI relates LUE to the de-epoxidation xanthophyll state which is linked to the biochemical mechanism down-regulating photosynthesis to prevent photo-oxidative damage in leaves. It is based on the reflectance at 531 and 570 nm, according to the following relationship PRI = (R531 - R570) = (R531 + R570). The aim of this study is to investigate the relationship between LUE and a scaled PRI (sPRI) for a Mediterranean Quercus cerris L. forest site (Roccarespampani, Viterbo, Italy) in two different years. Variations in canopy reflectance related to the xanthophyll cycle were detected using MODIS sensor ocean band 11 centered at 531 nm and band 12 (551 nm) was used as reference. Strong correlation between MODIS-sPRI and LUE were found, only during the wet year (2004), and only for backscattering scenes. Future studies could be investigated to test whether physiological reflectance signals are affected by sun position, heterogeneous landscape or atmospheric interfaces.

  7. Generating time series of PRI across the Amazon basin using hyperspectral Hyperion data

    NASA Astrophysics Data System (ADS)

    Toh Yuan Kun, L.; Yang, X.; Silva, C. E.; Cushman, K.; Kellner, J. R.

    2016-12-01

    Models of carbon cycling in tropical forests rely on estimates of fAPAR and LUE that are based on field experiments or remote sensing. However, much uncertainty surrounds such models on a regional scale because of unresolved questions over ecosystem response to climate variability. The photochemical reflectance index (PRI) is a normalized difference index that is sensitive to short-term changes in photosynthetic activity, unlike other more commonly used indices like NDVI. This is because PRI is indicative of the epoxidation state of xanthophyll pigments involved in non-photochemical quenching. Hence, an understanding of how PRI varies spatially and temporally would be a useful benchmark against which to evaluate model output and measurements of solar-induced fluorescence (SIF). Computing PRI requires two narrow spectral bands at 531 and 570 nm, and therefore cannot be quantified using broad-band optical sensors. The Hyperion instrument has generated Earth observations since 2000 and provides a unique opportunity to quantify PRI over large spatial and temporal scales. Here we describe a quantitative framework to correct striping, spectral keystone, and spectral smile inherent in the Hyperion data record. We show how these data can be used to generate time series of PRI to facilitate deeper understanding of photosynthetic activity in the Amazon basin.

  8. Effect and evaluation of prying action for top- and seat-angle connections

    NASA Astrophysics Data System (ADS)

    Ahmed, Ali; Hasan, Rafiq

    2015-06-01

    Nonlinear finite element (FE) static analyses of top- and seat-angle connections were performed using ABAQUS standard to investigate the influence of connection parameters and its properties on prying action developed due to the interaction between column flange and top angle's vertical leg. Contact phenomenon between two interfaces with finite sliding and bolt pretension in the initial step of analysis was considered in the FE model. FE analysis results were compared with the experimental ones to examine the applicability of the FE model. Then, the location of plastic hinges in connection assemblages was investigated at the ultimate state of the connection and a parametric study was performed varying connection parameters, material properties of connection assemblages, and magnitude of bolt pretension to visualize their effects on prying force and on the position of prying force on top angle's vertical leg. Current study shows that plastic hinges not only develop at top angle's heel and bolt hole region but also in the bolt shank that differs from some assumptions of power model (Kishi and Chen 1990): (1) top angle thickness and gage distance from angle heel to bolt hole center line have an distinct effect on prying action; and (2) distributed prying force developed near the region of the top edge of tension angle's leg adjacent to column flange can contribute to the failure of the connection. Finally, a mathematical formulation to identify the location of prying force action point is proposed.

  9. Retrospective review of Contura HDR breast cases to improve our standardized procedure

    SciTech Connect

    Iftimia, Ileana; Cirino, Eileen T.; Ladd, Ron; Mower, Herbert W.; McKee, Andrea B.

    2013-07-01

    To retrospectively review our first 20 Contura high dose rate breast cases to improve and refine our standardized procedure and checklists. We prepared in advance checklists for all steps, developed an in-house Excel spreadsheet for second checking the plan, and generated a procedure for efficient contouring and a set of optimization constraints to meet the dose volume histogram criteria. Templates were created in our treatment planning system for structures, isodose levels, optimization constraints, and plan report. This study reviews our first 20 high dose rate Contura breast treatment plans. We followed our standardized procedure for contouring, planning, and second checking. The established dose volume histogram criteria were successfully met for all plans. For the cases studied here, the balloon-skin and balloon-ribs distances ranged between 5 and 43 mm and 1 and 33 mm, respectively; air{sub s}eroma volume/PTV{sub E}val volume≤5.5% (allowed≤10%); asymmetry<1.2 mm (goal≤2 mm); PTV{sub E}val V90%≥97.6%; PTV{sub E}val V95%≥94.9%; skin max dose≤98%Rx; ribs max dose≤137%Rx; V150%≤29.8 cc; V200%≤7.8 cc; the total dwell time range was 225.4 to 401.9 seconds; and the second check agreement was within 3%. Based on this analysis, more appropriate ranges for the total dwell time and balloon diameter tolerance were found. Three major problems were encountered: balloon migration toward the skin for small balloon-to-skin distances, lumen obstruction, and length change for the flexible balloon. Solutions were found for these issues and our standardized procedure and checklists were updated accordingly. Based on our review of these cases, the use of checklists resulted in consistent results, indicating good coverage for the target without sacrificing the critical structures. This review helped us to refine our standardized procedure and update our checklists.

  10. Advanced human-system interface design review guideline. Evaluation procedures and guidelines for human factors engineering reviews

    SciTech Connect

    O`Hara, J.M.; Brown, W.S.; Baker, C.C.; Welch, D.L.; Granda, T.M.; Vingelis, P.J.

    1994-07-01

    Advanced control rooms will use advanced human-system interface (HSI) technologies that may have significant implications for plant safety in that they will affect the operator`s overall role in the system, the method of information presentation, and the ways in which operators interact with the system. The U.S. Nuclear Regulatory Commission (NRC) reviews the HSI aspects of control rooms to ensure that they are designed to good human factors engineering principles and that operator performance and reliability are appropriately supported to protect public health and safety. The principal guidance available to the NRC, however, was developed more than ten years ago, well before these technological changes. Accordingly, the human factors guidance needs to be updated to serve as the basis for NRC review of these advanced designs. The purpose of this project was to develop a general approach to advanced HSI review and the human factors guidelines to support. NRC safety reviews of advanced systems. This two-volume report provides the results of the project. Volume I describes the development of the Advanced HSI Design Review Guideline (DRG) including (1) its theoretical and technical foundation, (2) a general model for the review of advanced HSIs, (3) guideline development in both hard-copy and computer-based versions, and (4) the tests and evaluations performed to develop and validate the DRG. Volume I also includes a discussion of the gaps in available guidance and a methodology for addressing them. Volume 2 provides the guidelines to be used for advanced HSI review and the procedures for their use.

  11. Surgery for constipation: systematic review and practice recommendations: Results IV: Recto-vaginal reinforcement procedures.

    PubMed

    Grossi, U; Horrocks, E J; Mason, J; Knowles, C H; Williams, A B

    2017-09-01

    To assess the outcomes of recto-vaginal reinforcement procedures in adults with chronic constipation. Standardised methods and reporting of benefits and harms were used for all CapaCiTY reviews that closely adhered to PRISMA 2016 guidance. Main conclusions were presented as summary evidence statements with a summative Oxford Centre for Evidence-Based Medicine (2009) level. Forty-three articles were identified, providing data on outcomes in 3346 patients. Average length of procedures ranged between 20 and 169 min, and length of stay between 1 and 15 days. Complications typically occurred after 7-17% of procedures (range 0-61%). Post-operative bleeding was uncommon (0-4%) as well as haematoma or sepsis (0-2%). Fistulation did not occur in most studies. Two procedure-related deaths were observed for 3209 patients. Although inconsistent, 78% of patients reported a satisfactory or good outcome, with 30-50% experiencing reduced symptoms of straining, incomplete emptying or reduced vaginal digitation. About 17% of patients developed anatomical recurrence. Considering measures of harm and global satisfaction rating scales, there was insufficient evidence to prefer one type of procedure over another. There was no evidence to support better outcomes based on selection of patients with a particular size or grade of rectocoele. Evidence supporting recto-vaginal reinforcement procedures is currently derived from observational studies and comparisons, with only one high quality study. Large trials are needed to inform future clinical decision making. © 2017 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland.

  12. Systematic review of "filling" procedures for lip augmentation regarding types of material, outcomes and complications.

    PubMed

    San Miguel Moragas, Joan; Reddy, Rajgopal R; Hernández Alfaro, Federico; Mommaerts, Maurice Y

    2015-07-01

    The ideal lip augmentation technique provides the longest period of efficacy, lowest complication rate, and best aesthetic results. A myriad of techniques have been described for lip augmentation, but the optimal approach has not yet been established. This systematic review with meta-regression will focus on the various filling procedures for lip augmentation (FPLA), with the goal of determining the optimal approach. A systematic search for all English, French, Spanish, German, Italian, Portuguese and Dutch language studies involving FPLA was performed using these databases: Elsevier Science Direct, PubMed, Highwire Press, Springer Standard Collection, SAGE, DOAJ, Sweetswise, Free E-Journals, Ovid Lippincott Williams & Wilkins, Willey Online Library Journals, and Cochrane Plus. The reference section of every study selected through this database search was subsequently examined to identify additional relevant studies. The database search yielded 29 studies. Nine more studies were retrieved from the reference sections of these 29 studies. The level of evidence ratings of these 38 studies were as follows: level Ib, four studies; level IIb, four studies; level IIIb, one study; and level IV, 29 studies. Ten studies were prospective. This systematic review sought to highlight all the quality data currently available regarding FPLA. Because of the considerable diversity of procedures, no definitive comparisons or conclusions were possible. Additional prospective studies and clinical trials are required to more conclusively determine the most appropriate approach for this procedure. IV. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  13. A systematic review of the impact of volume of surgery and specialization in Norwood procedure

    PubMed Central

    2014-01-01

    Background The volume-outcome relationship is supposed to be stronger in high risk, low volume procedures. The aim of this systematic review is to examine the available literature on the effects of hospital and surgeon volume, specialization and regionalization on the outcomes of the Norwood procedure. Methods A systematic literature search was performed in Medline, Embase, and the Cochrane Library. On the basis of titles and abstracts, articles of comparative studies were obtained in full-text in case of potential relevance and assessed for eligibility according to predefined inclusion criteria. All relevant data on study design, patient characteristics, hospital volume, surgeon volume and other institutional characteristics, as well as results were extracted in standardized tables. Study selection, data extraction and critical appraisal were carried out independently by two reviewers. Results We included 10 studies. All but one study had an observational design. The number of analyzed patients varied from 75 to 2555. Overall, the study quality was moderate with a huge number of items with an unclear risk of bias. All studies investigating hospital volume indicated a hospital volume-outcome relationship, most of them even having significant results. The results were very heterogeneous for surgeon volume. Conclusions The volume-outcome relationship in the Norwood procedure can be supported. However, the magnitude of the volume effect is difficult to assess. PMID:25096305

  14. 21 CFR 601.25 - Review procedures to determine that licensed biological products are safe, effective, and not...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... by an advisory review panel, published and unpublished data and information pertinent to a designated... recommendations of the advisory review panel, the Commissioner of Food and Drugs shall publish in the Federal... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Review procedures to determine that licensed...

  15. 36 CFR 1260.58 - What are the procedures for requesting a mandatory review of White House originated information?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... more than 25 years old, NARA will review the records using systematic declassification guidance... requesting a mandatory review of White House originated information? 1260.58 Section 1260.58 Parks, Forests... NATIONAL SECURITY INFORMATION Mandatory Review § 1260.58 What are the procedures for requesting a mandatory...

  16. 36 CFR 1260.42 - What are the procedures for agency personnel to review records at a NARA facility?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SECURITY INFORMATION Systematic Review § 1260.42 What are the procedures for agency personnel to review... handling of archival materials. (b) Agency reviewers must: (1) Follow NARA security regulations and abide... NARA facility computers, scanners, tape recorders, microfilm readers and other equipment necessary to...

  17. USING VIDEO TECHNOLOGY TO DISSEMINATE BEHAVIORAL PROCEDURES: A REVIEW OF FUNCTIONAL ANALYSIS: A GUIDE FOR UNDERSTANDING CHALLENGING BEHAVIOR (DVD)

    PubMed Central

    Carr, James E; Fox, Eric J

    2009-01-01

    Although applied behavior analysis has generated many highly effective behavior-change procedures, the procedures have not always been effectively disseminated. One solution to this problem is the use of video technology, which has been facilitated by the ready availability of video production equipment and software and multiple distribution methods (e.g., DVD, online streaming). We review a recent DVD that was produced to disseminate the successful experimental functional analysis procedure. The review is followed by general recommendations for disseminating behavior-analytic procedures via video technology. PMID:20514204

  18. Application of mesenchymal stem cells in bone regenerative procedures in oral implantology. A literature review

    PubMed Central

    Viña, Jose A.; El-Alami, Marya; Gambini, Juan; Borras, Consuelo; Viña, Jose

    2014-01-01

    Objective: The aim of this work was to review de literature about the role of mesenchymal stem cells in bone regenerative procedures in oral implantology, specifically, in the time require to promote bone regeneration. Study Design: A bibliographic search was carried out in PUBMED with a combination of different key words. Animal and human studies that assessed histomorphometrically the influence of mesenchymal stem cells on bone regeneration procedures in oral implantology surgeries were examined. Reults: - Alveolar regeneration: Different controlled histomorphometric animal studies showed that bone regeneration is faster using stem cells seeded in scaffolds than using scaffolds or platelet rich plasma alone. Human studies revealed that stem cells increase bone regeneration. - Maxillary sinus lift: Controlled studies in animals and in humans showed higher bone regeneration applying stem cells compared with controls. - Periimplantary bone regeneration and alveolar distraction: Studies in animals showed higher regeneration when stem cells are used. In humans, no evidence of applying mesenchymal stem cells in these regeneration procedures was found. Conclusion: Stem cells may promote bone regeneration and be useful in bone regenerative procedures in oral implantology, but no firm conclusions can be drawn from the rather limited clinical studies so far performed. Key words:Mesenchymal stem cells, bone regeneration, dental implants, oral surgery, tissue engineering. PMID:24596637

  19. Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety.

    PubMed

    Barends, Clemens R M; Absalom, Anthony; van Minnen, Baucke; Vissink, Arjan; Visser, Anita

    2017-01-01

    To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation. We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine and midazolam for procedural sedation up to June 20, 2016. Inclusion criteria: clinical trial, human subjects, adult subjects (≥18 years), article written in English, German, French or Dutch, use of study medication for conscious sedation and at least one group receiving dexmedetomidine and one group receiving midazolam. Exclusion criteria: patients in intensive care, pediatric subjects and per protocol use of additional sedative medication other than rescue medication. Outcome measures for efficacy comparison were patient and clinician satisfaction scores and pain scores; outcome measures for safety comparison were hypotension, hypoxia, and circulatory and respiratory complications. We identified 89 papers, of which 12 satisfied the inclusion and exclusion criteria; 883 patients were included in these studies. Dexmedetomidine was associated with higher patient and operator satisfaction than midazolam. Patients receiving dexmedetomidine experienced less pain and had lower analgesic requirements. Respiratory and hemodynamic safety were similar. Dexmedetomidine is a promising alternative to midazolam for use in procedural sedation. Dexmedetomidine provides more comfort during the procedure for the patient and clinician. If carefully titrated, the safety profiles are similar.

  20. Positive Peer Reporting in the Classroom: a Review of Intervention Procedures.

    PubMed

    Murphy, Jillian; Zlomke, Kimberly

    2014-10-01

    Positive peer reporting (PPR) is a classroom-based intervention to improve social interactions between students using rewards and positive social attention. Along with a variant of the procedure referred to as "Tootling," PPR has demonstrated overwhelmingly positive results since its development. However, a unified, standard protocol for successful implementation of PPR interventions has not yet been established. A review of 24 studies, including 48 separately described cases of PPR in classroom settings, provided information concerning adaptations for students in special education, alternative school, and mainstream classrooms. Student participants ranged from preschool (age 4) to eighth grade (age 16). This paper summarizes the common procedural components found across cases described in the studies. A comparison of PPR-based interventions reported in the literature by various research teams also revealed differences in the procedures for targeting individuals or groups, providing training and support, allocating rewards, proceeding with daily peer report sessions, and terminating the intervention. Variations in specific procedural elements that may relate to PPR's effectiveness are discussed. The authors also provide suggestions to guide and support the advancement of standardized methods of PPR for future research and clinical application.

  1. Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety

    PubMed Central

    Absalom, Anthony; van Minnen, Baucke; Vissink, Arjan

    2017-01-01

    Objectives To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation. Materials and Methods We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine and midazolam for procedural sedation up to June 20, 2016. Inclusion criteria: clinical trial, human subjects, adult subjects (≥18 years), article written in English, German, French or Dutch, use of study medication for conscious sedation and at least one group receiving dexmedetomidine and one group receiving midazolam. Exclusion criteria: patients in intensive care, pediatric subjects and per protocol use of additional sedative medication other than rescue medication. Outcome measures for efficacy comparison were patient and clinician satisfaction scores and pain scores; outcome measures for safety comparison were hypotension, hypoxia, and circulatory and respiratory complications. Results We identified 89 papers, of which 12 satisfied the inclusion and exclusion criteria; 883 patients were included in these studies. Dexmedetomidine was associated with higher patient and operator satisfaction than midazolam. Patients receiving dexmedetomidine experienced less pain and had lower analgesic requirements. Respiratory and hemodynamic safety were similar. Conclusions Dexmedetomidine is a promising alternative to midazolam for use in procedural sedation. Dexmedetomidine provides more comfort during the procedure for the patient and clinician. If carefully titrated, the safety profiles are similar. PMID:28107373

  2. Optimal training design for procedural motor skills: a review and application to laparoscopic surgery.

    PubMed

    Spruit, Edward N; Band, Guido P H; Hamming, Jaap F; Ridderinkhof, K Richard

    2014-11-01

    This literature review covers the choices to consider in training complex procedural, perceptual and motor skills. In particular, we focus on laparoscopic surgery. An overview is provided of important training factors modulating the acquisition, durability, transfer, and efficiency of trained skills. We summarize empirical studies and their theoretical background on the topic of training complex cognitive and motor skills that are pertinent to proficiency in laparoscopic surgery. The overview pertains to surgical simulation training for laparoscopy, but also to training in other demanding procedural and dexterous tasks, such as aviation, managing complex systems and sports. Evidence-based recommendations are provided for facilitating efficiency in laparoscopic motor skill training such as session spacing, adaptive training, task variability, part-task training, mental imagery and deliberate practice.

  3. Review of procedures used for the extraction of anti-cancer compounds from tropical plants.

    PubMed

    Pandey, Saurabh; Shaw, Paul N; Hewavitharana, Amitha K

    2015-01-01

    Tropical plants are important sources of anti-cancer lead molecules. According to the US National Cancer Institute, out of the 3000 plants identified as active against cancer using in vitro studies, 70% are of tropical origin. The extraction of bioactive compounds from the plant materials is a fundamental step whose efficiency is critical for the success of drug discovery efforts. There has been no review published of the extraction procedures of anti-cancer compounds from tropical plants and hence the following is a critical evaluation of such procedures undertaken prior to the use of these compounds in cancer cell line studies, during the last five years. It presents a comprehensive analysis of all approaches taken to extract anti-cancer compounds from various tropical plants. (Databases searched were PubMed, SciFinder, Web of Knowledge, Scopus, Embase and Google Scholar).

  4. Continued Antiplatelet Therapy and Risk of Bleeding in Gastrointestinal Procedures: A Systematic Review.

    PubMed

    Fang, Xiao; Baillargeon, Jacques G; Jupiter, Daniel C

    2016-05-01

    Management of perioperative antiplatelet medications in gastrointestinal (GI) surgery is challenging. The risk of intraoperative and postoperative bleeding is associated with perioperative use of antiplatelet medication. However, cessation of these drugs may be unsafe for patients who are required to maintain antiplatelet use due to cardiovascular conditions. The objective of this systematic review was to compare the risk of intraoperative or postoperative bleeding among patients who had GI surgery while on continuous antiplatelet therapy (aspirin, clopidogrel, or dual therapy) with the risk among those not taking continuous antiplatelet medication. We reviewed articles published between January 2000 and July 2015 from the Medline Ovid and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases. Studies involving any GI procedures were included if the articles met our inclusion criteria (listed in Methods). The following key words were used for the search: clopidogrel, Plavix, aspirin, antiplatelet, bleeding, hemorrhage, and digestive system surgical procedures. Quality of the studies was assessed, depending on their study design, using the Newcastle-Ottawa score or the Cochrane Collaboration's tool for assessing risk of bias. Twenty-two studies were eligible for inclusion in the systematic review. Five showed that the risk of intraoperative bleeding or postoperative bleeding among patients who had GI surgery while on continuous antiplatelet therapy was higher compared that for those not on continuous therapy. The remaining 17 studies reported that there was no statistically significant difference in the risks of bleeding between the continuous antiplatelet therapy group and the group without continuous antiplatelet therapy. The risk of bleeding associated with GI procedures in patients receiving antiplatelet therapy was not significantly higher than in patients with no antiplatelet or interrupted antiplatelet therapy. Copyright © 2016 American

  5. Editor's Choice - Minimizing Radiation Exposure During Endovascular Procedures: Basic Knowledge, Literature Review, and Reporting Standards.

    PubMed

    Hertault, A; Maurel, B; Midulla, M; Bordier, C; Desponds, L; Saeed Kilani, M; Sobocinski, J; Haulon, S

    2015-07-01

    Endovascular procedures, requiring X-ray guidance, are commonly performed in vascular surgery. X-ray exposure is associated with biological risks for both patients and physicians. Medical X-ray use must follow "as low as reasonably achievable" (ALARA) principles, which aim at using the lowest radiation exposure to achieve a procedure safely. This is underlined by European and international recommendations that also suggest that adequate theoretical and practical training is mandatory during the initial education of physicians. However, the content of this education and professional practices vary widely from one country to another. This review aims to summarize the basic knowledge required for vascular surgeons on X-ray physics and image production. A panel of endovascular therapists (vascular surgeons and radiologists) and physicists dedicated to X-rays was gathered. International recommendations were summarized. A literature review was performed via MEDLINE to identify studies reporting dosages of common endovascular procedures. The different mechanisms inducing biological risks, and the associated potential effects on health, are described. Details on dose metrics are provided and a common nomenclature to measure, estimate, and report dose is proposed in order to perform accurate comparisons between publications and practices. Key points of the European and international legislation regarding medical X-ray use are summarized, and radiation protection basics for patients and staff, are detailed. Finally, a literature review is proposed for physicians to evaluate their practice. Today's trainees will be highly exposed to radiation throughout their practice. It is thus compulsory that they undergo dedicated radiation education during their initial training, and regular refresher sessions later. In daily practice, focus on dose reduction and monitoring of patient and staff exposure are mandatory. Copyright © 2015 European Society for Vascular Surgery. Published by

  6. Depth of anaesthesia monitoring during procedural sedation and analgesia: A systematic review and meta-analysis.

    PubMed

    Conway, Aaron; Sutherland, Joanna

    2016-11-01

    Processed electroencephalogram-based depth of anaesthesia monitoring devices provide an additional method to monitor level of consciousness during procedural sedation and analgesia. The objective of this systematic review was to determine whether using a depth of anaesthesia monitoring device improves the safety and efficacy of sedation. Systematic review and meta-analysis. Electronic databases (CENTRAL; Medline; CINAHL) were searched up to May 2015. Randomised controlled trials that compared use of a depth of anaesthesia monitoring device to a control group who received standard monitoring during procedural sedation and analgesia were included. Study selection, data extraction and risk of bias assessment (Cochrane risk of bias tool) were performed by two reviewers. Safety outcomes were hypoxaemia, hypotension and adverse events. Efficacy outcomes were amount of sedation used, duration of sedation recovery and rate of incomplete procedures. A total of 16 trials (2138 participants) were included. Evidence ratings were downgraded to either low or moderate quality due to study limitations and imprecision. Meta-analysis of 8 trials (766 participants) found no difference in hypoxaemia (RR 0.87; 95% CI=0.67-1.12). No statistically significant difference in hypotension was observed in meta-analysis of 8 trials (RR 0.96; 95% CI=0.54-1.7; 942 participants). Mean dose of propofol was 51mg lower for participants randomised to depth of anaesthesia monitoring (95% CI=-88.7 to -13.3mg) in meta-analysis of results from four trials conducted with 434 participants who underwent interventional endoscopy procedures with propofol infusions to maintain sedation. The difference in recovery time between depth of anaesthesia and standard monitoring groups was not clinically significant (standardised mean difference -0.41; 95% CI=-0.8 to -0.02; I(2)=86%; 8 trials; 809 participants). Depth of anaesthesia monitoring did impact sedation titration during interventional procedures with propofol

  7. Review of data analysis procedures for the ATS-6 millimeter wave experiment

    NASA Technical Reports Server (NTRS)

    Meneghini, R.

    1975-01-01

    Predictions of satellite downlink attenuation through the use of ground based measurements form a substantial part of the ATS-6 millimeter wave experiment (MWE). At the downlink frequencies (20 and 30 GHz), the major causes of attenuation are the density and the size distribution of rain drops along the propagation path. Ground station data, which include radar and rain gauge records, measure quantities related to the meteorological parameters of interest and thereby provide a prediction of downlink attenuation with which the measured attenuation can be compared. The calibration and data analysis procedures used in the MWE are reviewed with the object of improving the accuracy of such ground based predictions.

  8. Pain and anxiety management for pediatric dental procedures using various combinations of sedative drugs: A review.

    PubMed

    Gazal, Giath; Fareed, Wamiq Musheer; Zafar, Muhammad Sohail; Al-Samadani, Khalid H

    2016-07-01

    For fearful and uncooperative children behavioral management techniques are used. In order to control the pain and anxiety in pedodontic patients, pharmacologic sedation, anesthesia and analgesia are commonly used. Midazolam is commonly used as an oral sedation agent in children; it has several features such as safety of use, quick onset and certain degree of amnesia that makes it a desirable sedation agent in children. This review paper discusses various aspects of oral midazolam, ketamine and their combinations in conscious sedation including, advantages of oral route of sedation, pharmacokinetics, range of oral doses, and antagonists for clinical dental treatment procedures.

  9. A retrospective case note review of laparoscopic versus open reversal of Hartmann’s procedure

    PubMed Central

    Yeomans, NP

    2014-01-01

    Introduction First described in 1921, Hartmann’s procedure is the gold standard treatment for complicated sigmoid diverticular disease. It is also used commonly for other causes of perforation of the large bowel. However, the reversal rate in the UK is much lower than in comparable countries, at only 18–22%. Furthermore, laparoscopic reversal (LRH) is used far less frequently than open reversal (ORH) despite evidence that a laparoscopic technique reduces patient morbidity and decreases patient recovery time. Methods This retrospective case note review undertook an analysis of all the patients who had undergone Hartmann’s procedure at two centres in Leeds Teaching Hospitals NHS Trust between February 2007 and February 2012. Out of 305 patients, 235 were identified and included in the analysis. Comparisons were then drawn between LRH and ORH groups. Results The reversal rate was 21%. Three-quarters (76%) were performed using an open technique, 20% were laparoscopic and 5% were converted to an open procedure. The mean hospital stay was longer for the ORH group (9.82 days, standard deviation [SD]: 5.85 days, 95% confidence interval [CI]: 2.99 days) than for the LRH group (7.29 days, SD: 4.65 days, 95% CI: 11.58 days) p=0.006). Seven ORH patients (21%) were reoperated but only one LRH patient (13%) had a reoperation at six months. Five factors were found to have a significant effect on the likelihood of reversal of Hartmann’s procedure. Conclusions The overall reversal rate for Hartmann’s procedure remains low. Shorter hospital stays, lower 6-month reoperation rates and reduced 30-day complication rates are associated with LRH when compared with ORH. PMID:25245735

  10. The PRiMA-linked Cholinesterase Tetramers Are Assembled from Homodimers

    PubMed Central

    Chen, Vicky P.; Xie, Heidi Q.; Chan, Wallace K. B.; Leung, K. Wing; Chan, Gallant K. L.; Choi, Roy C. Y.; Bon, Suzanne; Massoulié, Jean; Tsim, Karl W. K.

    2010-01-01

    Acetylcholinesterase (AChE) is anchored onto cell membranes by the transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric globular form that is prominently expressed in vertebrate brain. In parallel, the PRiMA-linked tetrameric butyrylcholinesterase (BChE) is also found in the brain. A single type of AChE-BChE hybrid tetramer was formed in cell cultures by co-transfection of cDNAs encoding AChET and BChET with proline-rich attachment domain-containing proteins, PRiMA I, PRiMA II, or a fragment of ColQ having a C-terminal GPI addition signal (QN-GPI). Using AChE and BChE mutants, we showed that AChE-BChE hybrids linked with PRiMA or QN-GPI always consist of AChET and BChET homodimers. The dimer formation of AChET and BChET depends on the catalytic domains, and the assembly of tetramers with a proline-rich attachment domain-containing protein requires the presence of C-terminal “t-peptides” in cholinesterase subunits. Our results indicate that PRiMA- or ColQ-linked cholinesterase tetramers are assembled from AChET or BChET homodimers. Moreover, the PRiMA-linked AChE-BChE hybrids occur naturally in chicken brain, and their expression increases during development, suggesting that they might play a role in cholinergic neurotransmission. PMID:20566626

  11. A review of research on procedures for teaching safety skills to persons with developmental disabilities.

    PubMed

    Dixon, Dennis R; Bergstrom, Ryan; Smith, Marlena N; Tarbox, Jonathan

    2010-01-01

    Safety skills are an important but often neglected area of training for persons with developmental disabilities (DD). The present study reviewed the literature on teaching safety skills to persons with DD. Safety skills involve a variety of behaviors such as knowing how to cross the street or what to do in case of a house fire. A number of studies have been conducted on teaching these skills to individuals with DD. The studies reviewed have varying degrees of success and demonstrate varying degrees of generalization, but the general finding has been that prompting, reinforcement, and role-playing are effective teaching procedures across a variety of participants, skills, and settings. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  12. Bi-directional processing of pri-miRNAs with branched terminal loops by Arabidopsis Dicer-like1

    PubMed Central

    Zhu, Hongliang; Zhou, Yuyi; Castillo-González, Claudia; Lu, Amber; Ge, Chunxiao; Zhao, Ying-Tao; Duan, Liusheng; Li, Zhaohu; Axtell, Michael J.; Wang, Xiu-Jie; Zhang, Xiuren

    2013-01-01

    miRNAs originate from primary transcripts (pri-miRNAs) with characteristic stem-loop structures. Accurate processing of pri-miRNAs is required for functional miRNAs. Here, using pri-miR166 family as a paradigm, we report the decisive role of pri-miRNA terminal loops in miRNA biogenesis. We found that multi-branched terminal loops in pri-miR166s substantially suppressed miR166 expression in vivo. Unlike canonical processing of pri-miRNAs, terminal-loop-branched (TLBed) pri-miRNAs can be processed by Dicer-like1 (DCL1) complexes bi-directionally: from base to loop and from loop to base, resulting in productive and abortive processing of miRNAs, respectively. In either case, DCL1 complexes canonically cut pri-miRNAs at a distance of 16-17 base pairs (bp) from a reference single-stranded loop region. DCL1 also adjusts processing sites toward an internal loop through its helicase domain. Thus, these results provide new insight into the poorly understood processing mechanism of pri-miRNAs with complicated secondary structures. PMID:23934148

  13. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein

    PubMed Central

    Darwiche, Rabih; Kelleher, Alan; Hudspeth, Elissa M.; Schneiter, Roger; Asojo, Oluwatoyin A.

    2016-01-01

    The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and Pry2. Recombinant Pry1CAP forms dimers in solution, is sufficient for in vitro cholesterol binding, and has comparable binding properties as full-length Pry1. Two crystal structures of Pry1CAP are reported, one with Mg2+ coordinated to the conserved CAP tetrad (His208, Glu215, Glu233 and His250) in spacegroup I41 and the other without divalent cations in spacegroup P6122. The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one of which sits in the cholesterol binding site. Both structures reveal that the divalent cation and cholesterol binding sites are connected upon dimerization, providing a structural basis for the observed Mg2+-dependent sterol binding by Pry1. PMID:27344972

  14. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein

    NASA Astrophysics Data System (ADS)

    Darwiche, Rabih; Kelleher, Alan; Hudspeth, Elissa M.; Schneiter, Roger; Asojo, Oluwatoyin A.

    2016-06-01

    The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and Pry2. Recombinant Pry1CAP forms dimers in solution, is sufficient for in vitro cholesterol binding, and has comparable binding properties as full-length Pry1. Two crystal structures of Pry1CAP are reported, one with Mg2+ coordinated to the conserved CAP tetrad (His208, Glu215, Glu233 and His250) in spacegroup I41 and the other without divalent cations in spacegroup P6122. The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one of which sits in the cholesterol binding site. Both structures reveal that the divalent cation and cholesterol binding sites are connected upon dimerization, providing a structural basis for the observed Mg2+-dependent sterol binding by Pry1.

  15. Ravitch versus Nuss procedure for pectus excavatum: systematic review and meta-analysis

    PubMed Central

    Kanagaratnam, Aran; Phan, Steven; Tchantchaleishvilli, Vakhtang

    2016-01-01

    Background Pectus excavatum is the most common congenital chest wall deformity. The two most common surgical techniques for its correction are the modified Ravitch technique and the minimally invasive Nuss technique. Despite both procedures being used widely, data comparing them are scarce. Methods We conducted a systematic review and meta-analysis of comparative studies to evaluate these procedures. A systematic search of the literature was performed from six electronic databases. Pooled meta-analysis was conducted using odds ratio (OR) and weighted mean difference (WMD). Results A total of 13 studies comprising 1,432 pediatric (79.3%) and adult (20.7%) patients were identified, including 912 patients undergoing the Nuss procedure compared to 520 patients undergoing the Ravitch procedure. There was no significant difference found between the Nuss group versus Ravitch group in pediatric patients with regard to overall complications (OR =1.16; 95% CI: 0.61–2.19; I2=56%; P=0.65), reoperations (6.1% vs. 6.4%; OR =1.00; 95% CI: 0.40–2.50; I2=0%; P=1.00), wound infections (OR =0.58; 95% CI: 0.23–1.46; I2=0%; P=0.25), hemothorax (1.6% vs. 1.3%; OR =0.74; 95% CI: 0.21–2.65; I2=12%; P=0.64), pneumothorax (3.4% vs. 1.5%; OR =1.11; 95% CI: 0.42–2.93; I2=0%; P=0.83) or pneumonia (OR =0.15; 95% CI: 0.02–1.48; I2=0%; P=0.10). Adult patients undergoing the Nuss procedure had a higher incidence of overall complications (OR =3.26; 95% CI: 1.01–10.46; I2=0%; P=0.05), though there were far fewer studies that reported data. Conclusions These results suggest no difference between the Nuss and Ravitch procedures for pediatric patients, while in adults the Ravitch procedure resulted in fewer complications. PMID:27747174

  16. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain...

  17. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain...

  18. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain...

  19. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain...

  20. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain...

  1. "Non-filling" procedures for lip augmentation: a systematic review of contemporary techniques and their outcomes.

    PubMed

    Moragas, Joan San Miguel; Vercruysse, Herman Junior; Mommaerts, Maurice Y

    2014-09-01

    Ideal lip augmentation techniques have good longevity, low complication rates, and optimal functional and aesthetic results. No systematic review is currently available regarding the efficacy of lip augmentation techniques. This review will focus only on non-filling procedures for lip augmentation (NFPLAs). Current databases Elsevier Science Direct, PubMed, HighWire Press, Springer Standard Collection, SAGE, DOAJ, Sweetswise, Free E-Journals, Ovid Lippincott Williams & Wilkins, Willey Online Library Journals and Cochrane Plus were scrutinized and relevant article reference sections were studied for additional publications. The search heading sequence used was ("Lip" or "Mouth" or "Perioral" or "Nasolabial") and ("Augmentation" or "Enhancement" or "Surgery" or "Lift" or "V-Y" or "Corner"). Exclusion criteria applied to 6436 initial keyword-search retrievals yielded 12 articles. Eight more articles were retrieved from reference sections, for a total of 18 papers assessed. Only one article made a direct comparison of efficacy between two surgical techniques for lip augmentation, and none directly compared complications associated with different NFPLAs. Although this systematic review revealed a lack of quality data in comparing the efficacy and complications among different NFPLAs, it is important to review and pool the existing studies to better suggest proper treatment to patients. Copyright © 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  2. Procedural guidance for reviewing exposure information under RCRA (Resource Conservation and Recovery Act) section 3019. Final report

    SciTech Connect

    Grogan, T.; Kayser, R.

    1986-09-26

    This guidance manual describes the procedures for permit writers in evaluating exposure information submitted under Resource Conservation and Recovery Act (RCRA) Section 3019. The integration of the review with existing RCRA permitting activities is also discussed. The document outlines procedures to follow in referring sites to the Agency for Toxic Substances and Disease Registry (ATSDR) for health evaluations.

  3. 38 CFR 16.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 16.110 Section 16.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.110 Expedited review procedures for certain kinds of research...

  4. A systematic review of complication risks for HIV-positive patients undergoing invasive dental procedures.

    PubMed

    Patton, Lauren L; Shugars, Daniel A; Bonito, Arthur J

    2002-02-01

    This systematic literature review determined the strength of evidence regarding whether patients with human immunodeficiency virus, or HIV, are at higher risk of developing complications from invasive oral procedures than similar patients without HIV. MEDLINE and EMBASE searches of the English literature from the early 1980s through April 2000 yielded five articles meeting the inclusion and exclusion criteria: original research, concurrent treatment of HIV-positive and HIV-negative subjects, presence of complications (for example, local or systemic infection, bleeding, alveolitis, delayed healing) resulting from extractions, orthognathic surgery, periodontal therapy, endodontic therapy, placement of dental implants, prophylaxis, or scaling and root planing. The authors found no studies involving orthognathic surgery, periodontal therapy, dental implants, prophylaxis, or scaling and root planing, and only one study reporting few immediate endodontic therapeutic complications. Thus, the evidence is insufficient with respect to any additional risk associated with these procedures among people with HIV/AIDS. Because of the few studies, low overall complication rates and variability in results from different analytic approaches, the authors consider the evidence to be too poor to rule in or out a meaningful relationship between HIV status and complications from tooth extractions. Limited published scientific evidence is available to guide clinicians in regard to possible increased risks of invasive oral procedures associated with the HIV status of the patient.

  5. Do medical procedures in the arm increase the risk of lymphoedema after axillary surgery? A review.

    PubMed

    Cheng, Chris-Tin; Deitch, Jessica M; Haines, Ian E; Porter, David J; Kilbreath, Sharon L

    2014-01-01

    Lymphoedema of the arm is a potentially serious consequence of any axillary procedure performed during the management of breast cancer. In an attempt to reduce its incidence and severity, patients are instructed to avoid venepunctures and blood pressure measurements on the treated arm. These precautions are not possible in some patients and attempts to adhere to them can cause discomfort, anxiety and stress for both patients and their health-care workers. The strength with which these recommendations are made is in contrast to the level of evidence underpinning them. This paper reviews this evidence regarding the safety, or lack thereof, of blood pressure monitoring and intravenous puncture in women who have had axillary surgery. With this evidence generally being anecdotal in nature, there appears to be no rigorous evidence-based support for the risk-reduction behaviours of avoiding blood pressure monitoring and venepuncture in the affected arm in the prevention of lymphoedema after axillary procedure. A clinical trial was proposed to investigate whether such avoidance measures were valuable, but failed during its inception. There remains a need for research from prospective trials on this controversial topic to determine the most appropriate patient recommendations that should be provided after axillary procedure regarding the risks for development of lymphoedema.

  6. Fetal blood sampling in baboons (Papio spp.): important procedural aspects and literature review.

    PubMed

    Joy, S D; O'Shaughnessy, R; Schlabritz-Loutsevitch, N; Leland, M M; Frost, P; Fan-Havard, P

    2009-06-01

    The baboons (Papio cynocephalus) have similarities with human placentation and fetal development. Fetal blood sampling allows investigators to assess fetal condition at a specific point in gestation as well as transplacental transfer of medications. Unfortunately, assessing fetal status during gestation has been difficult and fetal instrumentation associated with high rate of pregnancy loss. Our objectives are to describe the technique of ultrasound guided cordocentesis (UGC) in baboons, report post-procedural outcomes, and review existing publications. This is a procedural paper describing the technique of UGC in baboons. After confirming pregnancy and gestational age via ultrasound, animals participating in approved research protocols that required fetal assessment underwent UGC. We successfully performed UGC in four animals (five samples) using this technique. Animals were sampled in the second and third trimesters with fetal blood sampling achieved by sampling a free cord loop, placental cord insertion site or the intrahepatic umbilical vein. All procedures were without complication and these animals delivered at term. Ultrasound guided fetal umbilical cord venipuncture is a useful and safe technique to sample the fetal circulation with minimal risk to the fetus or mother. We believe this technique could be used for repeated fetal venous blood sampling in the baboons.

  7. Review of edgematchimg procedures for digital cartographic data used in Geographic Information Systems (GIS)

    USGS Publications Warehouse

    Nebert, D.D.

    1989-01-01

    In the process of developing a continuous hydrographic data layer for water resources applications in the Pacific Northwest, map-edge discontinuities in the U.S. Geological Survey 1:100 ,000-scale digital data that required application of computer-assisted edgematching procedures were identified. The spatial data sets required by the project must have line features that match closely enough across map boundaries to ensure full line topology when adjacent files are joined by the computer. Automated edgematching techniques are evaluated as to their effects on positional accuracy. Interactive methods such as selective node-matching and on-screen editing are also reviewed. Interactive procedures complement automated methods by allowing supervision of edgematching in a cartographic and hydrologic context. Common edge conditions encountered in the preparation of the Northwest Rivers data base are described, as are recommended processing solutions. Suggested edgematching procedures for 1:100,000-scale hydrography data are included in an appendix to encourage consistent processing of this theme on a national scale. (USGS)

  8. [Psychotherapy and psychological procedures for fibromyalgia syndrome : Updated guidelines 2017 and overview of systematic review articles].

    PubMed

    Köllner, V; Bernardy, K; Greiner, W; Krumbein, L; Lucius, H; Offenbächer, M; Sarholz, M; Settan, M; Häuser, W

    2017-06-01

    The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was scheduled for April 2017. The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest. A systematic search of the literature for systematic reviews of randomized, controlled studies on psychological and psychotherapeutic procedures from December 2010 to May 2016 was performed in the Cochrane library, MEDLINE, PsycINFO and Scopus databases. Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine version 2009. The strength of recommendations was achieved by multiple step formalized procedures to reach a consensus. Efficacy, risks, patient preferences and applicability of available therapies were weighed up against each other. The guidelines were reviewed and approved by the board of directors of the societies engaged in the development of the guidelines. Cognitive behavioral therapies received a strong recommendation but biofeedback, guided imagery and hypnosis received a weak recommendation.

  9. Minor surgery procedures: A retrospective review and prospective survey in a pediatric population

    PubMed Central

    Chan, Emily; Bucevska, Marija; Verchere, Cynthia

    2015-01-01

    OBJECTIVE: The present study evaluated minor surgery procedures undertaken by a single plastic surgeon at BC Children’s Hospital (Vancouver, British Columbia) for patient and physician satisfaction, parent impressions, psychological concerns and complications. METHODS: Data were collected from a retrospective chart review and a prospective patient survey. Eligible subjects for the retrospective study included all pediatric patients undergoing minor surgery between May 2011 and April 2013. Parameters of interest included patient demographics, minor surgery specifics, complications and outcomes. Eligible subjects for the prospective patient survey included consecutive patients undergoing minor surgery between June 2013 and August 2013, as well as their parents. RESULTS: A total of 219 procedures were included in the retrospective review. The mean age of subjects was 13.1 years (range two weeks to 18 years). The median length of follow-up was 46 days (range four to 606 days). There were no major complications; however, 45 minor complications in 36 patients were found. Complications included crusting (4.6%), delayed wound healing (3.2%), hypersensitivity (2.3%), scar hypertrophy (1.8%), infection (0.9%) and other (7.8%). Outcomes were categorized as one of four outcomes: both satisfied (89.9%); patient satisfied but physician unsatisfied (0.8%); patient unsatisfied and physician satisfied (3.1%); and both unsatisfied (6.2%). In the prospective study, 32 subjects consented to participate in the survey. Of these subjects, 10 children and 12 parents responded to the questionnaires. Eighty-three percent of respondents indicated that their goals were accomplished by their procedure and that they would be willing to undergo minor surgery again. CONCLUSION: Minor surgery is possible and practical in pediatric plastic surgery clinics, with few complications and high patient and surgeon satisfaction. PMID:26361627

  10. Photochemical Reflectance Index (PRI) and remote sensing of plant CO2 uptake

    NASA Astrophysics Data System (ADS)

    Penuelas, J.; Garbulsky, M. F.; Filella, I.

    2011-12-01

    An accurate continuous quantification of the role of terrestrial ecosystems as carbon sinks everywhere constitutes a key issue in the face of ongoing environmental disturbance and climate change. The emerging consistency of the relationship between Photochemical Reflectance Index (PRI) and light use efficiency at the leaf, canopy and ecosystem scales offers promising prospects for continuous global monitoring of plant primary productivity from space. We will present and discuss this consistency. This reflectance index is based on the short term reversible xanthophyll pigment changes accompanying plant stress. It also behaves as an index of the chlorophyll:carotenoid ratios and therefore of the photosynthetic activities associated with their changes with leaf development, aging or stress at longer term. At the leaf and canopy levels, the PRI has been extensively found adequate to estimate LUE and thus photosynthetic performance, i.e. gross primary productivity, and its use has been extended increasingly in the last few years both in natural and semi-natural vegetation and in crops. The results of these studies confirm an exponential relationship between LUE and PRI over a wide range of species and conditions, hence suggesting that the overall photosynthetic system is often sufficiently regulated to maintain consistent relationships between the pigment, morphological and physiological changes linked to PRI and the changes in CO2 fixation. In a further step forward, with the availability of the MODIS sensor on TERRA and AQUA satellites, PRI is now increasingly used also at the ecosystem scale. The results of our study comparing PRI data from MODIS and CO2 exchange data from eddy covariance towers show that there may even be a common exponential relationship for all of forests. The emerging consistency of the relationship between PRI, LUE and ecosystem CO2 uptake increasingly found in these studies suggests a surprising degree of "functional convergence" of biochemical

  11. Diurnal and Directional Responses of Chlorophyll Fluorescence and the PRI in a Cornfield

    NASA Technical Reports Server (NTRS)

    Middleton, Elizabeth; Cheng, Y. B.; Corp, L.; Campbell, P.; Kustas, W.

    2010-01-01

    Determining the health and vigor of vegetation using high spectral resolution remote sensing is an important goal which has application to monitoring agriculture and ecosystem productivity and carbon exchange. Two spectral indices used to assess whether vegetation is performing near-optimally or exhibiting symptoms of environmental stress (e.g., drought or nutrient deficiency, non-optimal temperatures, etc.) are the Photochemical Reflectance Index (PRI) and solar-induced red and far-red Chlorophyll Fluorescence (Fs). Both the PRI and Fs capture the dynamics of photoprotection mechanisms within green foliage: the PRI is based on the association of the reflected radiation in the green spectrum with the xanthophyll cycle, whereas Fs measures the emitted radiation in the red and far-red spectrum. Fs was determined from retrievals in the atmospheric oxygen absorption features centered at 688 and 760 nm using a modified Fraunhofer Line Depth (FLD) method. We previously demonstrated diurnal and seasonal PRI differences for sunlit vs. shaded foliage in a conifer forest canopy, as expressed in the hotspot and darkspot of the Bidirectional Reflectance Function (BRF). In a USDA-ARS experimental field site located in Beltsville, MD, USA, measurements were acquired over a corn crop from a nadir view in 2008 with an ASD FieldSpec Pro (Analytical Spectral Devices, Inc., Boulder, CO, USA) to study the behavior of the PRI for sunlit and shaded foliage as captured in reflectance variations associated with the BRF, in a I m tall canopy in the vegetative growth stage. Those observations were compared to simulations obtained from two radiative transfer models. Measurements were then acquired to examine whether the PRI and Fs were influenced by view zenith and azimuth geometries at different times of day. Those measurements were made in 2010 with the Ocean Optics USB4000 Miniature Fiber Optic Spectrometer (Ocean Optics Inc., Dunedin, Florida, USA) at several times during the day on

  12. Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs

    PubMed Central

    Szarzynska, Bogna; Sobkowiak, Lukasz; Pant, Bikram Datt; Balazadeh, Salma; Scheible, Wolf-Rüdiger; Mueller-Roeber, Bernd; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia

    2009-01-01

    Arabidopsis thaliana HYL1 is a nuclear double-stranded RNA-binding protein involved in the maturation of pri-miRNAs. A quantitative real-time PCR platform for parallel quantification of 176 pri-miRNAs was used to reveal strong accumulation of 57 miRNA precursors in the hyl1 mutant that completely lacks HYL1 protein. This approach enabled us for the first time to pinpoint particular members of MIRNA family genes that require HYL1 activity for efficient maturation of their precursors. Moreover, the accumulation of miRNA precursors in the hyl1 mutant gave us the opportunity to carry out 3′ and 5′ RACE experiments which revealed that some of these precursors are of unexpected length. The alignment of HYL1-dependent miRNA precursors to A. thaliana genomic sequences indicated the presence of introns in 12 out of 20 genes studied. Some of the characterized intron-containing pri-miRNAs undergo alternative splicing such as exon skipping or usage of alternative 5′ splice sites suggesting that this process plays a role in the regulation of miRNA biogenesis. In the hyl1 mutant intron-containing pri-miRNAs accumulate alongside spliced pri-miRNAs suggesting the recruitment of HYL1 into the miRNA precursor maturation pathway before their splicing occurs. PMID:19304749

  13. Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs.

    PubMed

    Szarzynska, Bogna; Sobkowiak, Lukasz; Pant, Bikram Datt; Balazadeh, Salma; Scheible, Wolf-Rüdiger; Mueller-Roeber, Bernd; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia

    2009-05-01

    Arabidopsis thaliana HYL1 is a nuclear double-stranded RNA-binding protein involved in the maturation of pri-miRNAs. A quantitative real-time PCR platform for parallel quantification of 176 pri-miRNAs was used to reveal strong accumulation of 57 miRNA precursors in the hyl1 mutant that completely lacks HYL1 protein. This approach enabled us for the first time to pinpoint particular members of MIRNA family genes that require HYL1 activity for efficient maturation of their precursors. Moreover, the accumulation of miRNA precursors in the hyl1 mutant gave us the opportunity to carry out 3' and 5' RACE experiments which revealed that some of these precursors are of unexpected length. The alignment of HYL1-dependent miRNA precursors to A. thaliana genomic sequences indicated the presence of introns in 12 out of 20 genes studied. Some of the characterized intron-containing pri-miRNAs undergo alternative splicing such as exon skipping or usage of alternative 5' splice sites suggesting that this process plays a role in the regulation of miRNA biogenesis. In the hyl1 mutant intron-containing pri-miRNAs accumulate alongside spliced pri-miRNAs suggesting the recruitment of HYL1 into the miRNA precursor maturation pathway before their splicing occurs.

  14. PRI-Modeler: extracting RNA structural elements from PDB files of protein-RNA complexes.

    PubMed

    Han, Kyungsook; Nepal, Chirag

    2007-05-01

    A complete understanding of protein and RNA structures and their interactions is important for determining the binding sites in protein-RNA complexes. Computational approaches exist for identifying secondary structural elements in proteins from atomic coordinates. However, similar methods have not been developed for RNA, due in part to the very limited structural data so far available. We have developed a set of algorithms for extracting and visualizing secondary and tertiary structures of RNA and for analyzing protein-RNA complexes. These algorithms have been implemented in a web-based program called PRI-Modeler (protein-RNA interaction modeler). Given one or more protein data bank files of protein-RNA complexes, PRI-Modeler analyzes the conformation of the RNA, calculates the hydrogen bond (H bond) and van der Waals interactions between amino acids and nucleotides, extracts secondary and tertiary RNA structure elements, and identifies the patterns of interactions between the proteins and RNAs. This paper presents PRI-Modeler and its application to the hydrogen bond and van der Waals interactions in the most representative set of protein-RNA complexes. The analysis reveals several interesting interaction patterns at various levels. The information provided by PRI-Modeler should prove useful for determining the binding sites in protein-RNA complexes. PRI-Modeler is accessible at http://wilab.inha.ac.kr/primodeler/, and supplementary materials are available in the analysis results section at http://wilab.inha.ac.kr/primodeler/.

  15. Therapeutic efficacy of cold therapy after intraoral surgical procedures: a literature review.

    PubMed

    Greenstein, Gary

    2007-05-01

    Cryotherapy (e.g., ice pack) is prescribed commonly after oral surgery to inhibit swelling and discomfort. However, there is a dearth of data concerning various aspects of cold therapy: optimal delivery mode, best interval for application (time on/time off), and total duration of treatment to attain desired clinical outcomes. The literature was searched for clinical trials that assessed the benefits of cryotherapy after oral surgical procedures. In addition, other studies were reviewed that evaluated physiological responses to cold therapy. To inhibit signs of inflammation and achieve beneficial results with cryotherapy, skin temperature (normally 33 degrees C) needs to be reduced to 10 degrees C to 15 degrees C. Cold therapy usually decreased skin temperature to 10 degrees C to 15 degrees C within 10 to 20 minutes. Physiological studies indicated cryotherapy resulted in vasoconstriction, reduction of edema, and diminished pain perception. Various methods can be used to lower tissue temperature. Ice or gel packs are easy and efficient techniques to cool tissues. Seven studies published in English were found that addressed the use of cryotherapy after oral surgical procedures. Five investigations demonstrated no clinical benefits from cold therapy, and two studies indicated that cryotherapy reduced post-surgical edema and pain. The time interval for cold applications varied in different studies (10 minutes to continuous for hours). There seemed to be consensus among clinicians that cryotherapy should be applied for 10 to 20 minutes followed by a rest period. The duration of therapy ranged from 2 to 72 hours. No clinical trials were conducted to determine the optimal interval of cold application (time on/off) or extended duration of cryotherapy after surgical procedures to attain the best therapeutic benefits. Ice applied after surgical procedures may reduce swelling and discomfort. However, data from studies regarding the benefits of ice therapy after oral surgery

  16. Documentation of various approaches and outcomes in patients on warfarin undergoing dental procedures: a review article

    PubMed Central

    Shaer, Fayez El; Raslan, Ismael; Osaimi, Nora Al; Bawazeer, Ghada; Alayobi, Fhakr; Alhogbani, Tarek; Kharabsheh, Suliman; Habeeb, Walid Al

    2016-01-01

    Appropriate management of patients with mechanical prosthetic valves on warfarin during dental procedures is crucial. If the patients continue warfarin, they might develop bleeding, while interruption of therapy can cause thromboembolic events. Bridging therapy (mostly heparin) is used in some patients, while others stop medications. There is no unifying protocol. Information on management of patients on warfarin undergoing dental procedures in Saudi Arabia is lacking. Therefore, the current study aimed to provide more insight into various approaches utilized by clinicians to deal with such patients at a large teaching hospital in Riyadh, and to evaluate the frequency and severity of bleeding and thromboembolic complications during different types of dental procedures in this population. This was a cohort study. Patient records were used to collect data on peri-procedural management of patients on warfarin, continuation or interruption of warfarin therapy, as well as bleeding and thromboembolic complications. Fifty medical records were reviewed from March to October 2012. Regarding management, 10% had no proper documentation, 74% underwent bridging therapy, 12% discontinued warfarin therapy, and 4% continued warfarin. Of the patients, 31% had minor bleeding (15% in patients on bridging therapy and 16% in patients continuing warfarin). Thromboembolic complications were documented in 4%, (2% in those on bridging therapy and 2% in those discontinuing warfarin). Patients on bridging therapy (heparin) were admitted to the hospital for a mean of five days, and none of the other patients were admitted. Adopting the protocol to continue warfarin caused bleeding tendency that was controlled with the usual measures, with more cost effectiveness, and no thromboembolic risks. PMID:27679745

  17. The Manchester procedure versus vaginal hysterectomy in the treatment of uterine prolapse: a review.

    PubMed

    Tolstrup, Cæcilie Krogsgaard; Lose, Gunnar; Klarskov, Niels

    2017-01-01

    Uterine prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of uterine prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for uterine prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes. We systematically searched Embase, PubMed, the Cochrane databases, Clinicaltrials and Clinical trials register using the MeSh terms "uterine prolapse", "uterus prolapse", "vaginal prolapse" "pelvic organ prolapse", "prolapsed uterus", "Manchester procedure" and "vaginal hysterectomy". No limitations regarding language, study design or methodology were applied. In total, nine studies published from 1966 to 2014 comparing the MP to VH were included. The anatomical recurrence rate for the middle compartment was 4-7 % after VH, whereas recurrence was very rare after the MP. The re-operation rate because of symptomatic recurrence was higher after VH (9-13.1 %) compared with MP (3.3-9.5 %) and more patients needed conservative re-intervention (14-15 %) than after MP (10-11 %). After VH, postoperative bleeding and blood loss tended to be greater, bladder lesions and infections more frequent and the operating time longer. This review is in favour of the MP, which seems to be an efficient and safe treatment for uterine prolapse. We suggest that the MP might be considered a durable alternative to VH in uterine prolapse repair.

  18. Effect of music in endoscopy procedures: systematic review and meta-analysis of randomized controlled trials.

    PubMed

    Wang, Man Cai; Zhang, Ling Yi; Zhang, Yu Long; Zhang, Ya Wu; Xu, Xiao Dong; Zhang, You Cheng

    2014-10-01

    Endoscopies are common clinical examinations that are somewhat painful and even cause fear and anxiety for patients. We performed this systematic review and meta-analysis of randomized controlled trials to determine the effect of music on patients undergoing various endoscopic procedures. We searched the Cochrane Library, Issue 6, 2013, PubMed, and EMBASE databases up to July 2013. Randomized controlled trials comparing endoscopies, with and without the use of music, were included. Two authors independently abstracted data and assessed risk of bias. Subgroup analyses were performed to examine the impact of music on different types of endoscopic procedures. Twenty-one randomized controlled trials involving 2,134 patients were included. The overall effect of music on patients undergoing a variety of endoscopic procedures significantly improved pain score (weighted mean difference [WMD] = -1.53, 95% confidence interval [CI] [-2.53, -0.53]), anxiety (WMD = -6.04, 95% CI [-9.61, -2.48]), heart rate (P = 0.01), arterial pressure (P < 0.05), and satisfaction score (SMD = 1.83, 95% CI [0.76, 2.91]). Duration of the procedure (P = 0.29), except for gastrointestinal endoscopy (P = 0.03), and sedative or analgesic medication dose (P = 0.23, P = 0.12, respectively) were not significantly decreased in the music group, compared with the control group. Furthermore, music had little effect for patients undergoing colposcopy and bronchoscopy in the subanalysis. Our meta-analysis suggested that music may offer benefits for patients undergoing endoscopy, except in colposcopy and bronchoscopy. Wiley Periodicals, Inc.

  19. Subnuclear compartmentalization of transiently expressed polyadenylated pri-microRNAs: processing at transcription sites or accumulation in SC35 foci.

    PubMed

    Pawlicki, Jan M; Steitz, Joan A

    2009-02-01

    MicroRNAs (miRNAs) are small, noncoding RNAs that post-transcriptionally regulate expression of their target messenger RNAs. We recently demonstrated that primary miRNA transcripts (pri-miRNAs) retained at transcription sites are processed with enhanced efficiency, suggesting that pri-miRNA processing is coupled to transcription in mammalian cells. We also observed that transiently expressed pri-miRNAs accumulate in nuclear foci with splicing factor SC35 and Microprocessor components, Drosha and DGCR8. Here, we show that pri-miRNAs containing a self-cleaving hepatitis delta ribozyme accumulate in the nucleoplasm after release from their transcription sites, but are not efficiently processed. Pri-miRNAs with ribozyme-generated 3' ends do not localize to SC35-containing foci, whereas cleaved and polyadenylated pri-miRNA transcripts with or without the pre-miRNA hairpin do. Pri-miRNA/SC35 foci contain a number of proteins normally associated with SC35 domains, including ASF/SF2, PABII, and the prolyl isomerase, Pin1. In contrast, RNA polymerase II and PM/Scl-100 do not strongly colocalize with pri-miRNAs in SC35-containing foci. These data argue that pri-miRNA/SC35-containing foci are not major sites of pri-miRNA processing and that pri-miRNA processing is coupled to transcription. We discuss the implications of our findings relative to recent insights into miRNA biogenesis, mRNA metabolism, and the nuclear organization of gene expression.

  20. Modern meta-heuristics based on nonlinear physics processes: A review of models and design procedures

    NASA Astrophysics Data System (ADS)

    Salcedo-Sanz, S.

    2016-10-01

    Meta-heuristic algorithms are problem-solving methods which try to find good-enough solutions to very hard optimization problems, at a reasonable computation time, where classical approaches fail, or cannot even been applied. Many existing meta-heuristics approaches are nature-inspired techniques, which work by simulating or modeling different natural processes in a computer. Historically, many of the most successful meta-heuristic approaches have had a biological inspiration, such as evolutionary computation or swarm intelligence paradigms, but in the last few years new approaches based on nonlinear physics processes modeling have been proposed and applied with success. Non-linear physics processes, modeled as optimization algorithms, are able to produce completely new search procedures, with extremely effective exploration capabilities in many cases, which are able to outperform existing optimization approaches. In this paper we review the most important optimization algorithms based on nonlinear physics, how they have been constructed from specific modeling of a real phenomena, and also their novelty in terms of comparison with alternative existing algorithms for optimization. We first review important concepts on optimization problems, search spaces and problems' difficulty. Then, the usefulness of heuristics and meta-heuristics approaches to face hard optimization problems is introduced, and some of the main existing classical versions of these algorithms are reviewed. The mathematical framework of different nonlinear physics processes is then introduced as a preparatory step to review in detail the most important meta-heuristics based on them. A discussion on the novelty of these approaches, their main computational implementation and design issues, and the evaluation of a novel meta-heuristic based on Strange Attractors mutation will be carried out to complete the review of these techniques. We also describe some of the most important application areas, in

  1. A Meta-Analytic Review of the Cover-Copy-Compare and Variations of This Self-Management Procedure

    ERIC Educational Resources Information Center

    Joseph, Laurice M.; Konrad, Moira; Cates, Gary; Vajcner, Terra; Eveleigh, Elisha; Fishley, Katelyn M.

    2012-01-01

    Studies that examined copy-cover-compare (CCC) and variations of this procedure were reviewed and analyzed. This review revealed a substantial number of studies that validated the use of CCC across spelling and math skills and across students with and without disabilities. A meta-analysis of findings indicated that CCC and variations of this…

  2. A Meta-Analytic Review of the Cover-Copy-Compare and Variations of This Self-Management Procedure

    ERIC Educational Resources Information Center

    Joseph, Laurice M.; Konrad, Moira; Cates, Gary; Vajcner, Terra; Eveleigh, Elisha; Fishley, Katelyn M.

    2012-01-01

    Studies that examined copy-cover-compare (CCC) and variations of this procedure were reviewed and analyzed. This review revealed a substantial number of studies that validated the use of CCC across spelling and math skills and across students with and without disabilities. A meta-analysis of findings indicated that CCC and variations of this…

  3. Systematic Review: Predisposing, Precipitating, Perpetuating, and Present Factors Predicting Anticipatory Distress to Painful Medical Procedures in Children

    PubMed Central

    Pillai Riddell, Rebecca R.; Khan, Maria; Calic, Masa; Taddio, Anna; Tablon, Paula

    2016-01-01

    Objective To conduct a systematic review of the factors predicting anticipatory distress to painful medical procedures in children. Methods A systematic search was conducted to identify studies with factors related to anticipatory distress to painful medical procedures in children aged 0–18 years. The search retrieved 7,088 articles to review against inclusion criteria. A total of 77 studies were included in the review. Results 31 factors were found to predict anticipatory distress to painful medical procedures in children. A narrative synthesis of the evidence was conducted, and a summary figure is presented. Conclusions Many factors were elucidated that contribute to the occurrence of anticipatory distress to painful medical procedures. The factors that appear to increase anticipatory distress are child psychopathology, difficult child temperament, parent distress promoting behaviors, parent situational distress, previous pain events, parent anticipation of distress, and parent anxious predisposition. Longitudinal and experimental research is needed to further elucidate these factors. PMID:26338981

  4. ALPPS Procedure for Extended Liver Resections: A Single Centre Experience and a Systematic Review

    PubMed Central

    Vivarelli, Marco; Vincenzi, Paolo; Montalti, Roberto; Fava, Giammarco; Tavio, Marcello; Coletta, Martina; Vecchi, Andrea; Nicolini, Daniele; Agostini, Andrea; Ali Ahmed, Emad; Giovagnoni, Andrea; Mocchegiani, Federico

    2015-01-01

    Aim To report a single-centre experience with the novel Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) technique and systematically review the related literature. Methods Since January 2013, patients with extended primary or secondary liver tumors whose future liver remnant (FLR) was considered too small to allow hepatic resection were prospectively assessed for the ALPPS procedure. A systematic literature search was performed using PubMed, Scopus and the Cochrane Library Central. Results Until July 2014 ALPPS was completed in 9 patients whose mean age was 60±8 years. Indications for surgical resection were metastases from colorectal cancer in 3 cases, perihilar cholangiocarcinoma in 3 cases, intrahepatic cholangiocarcinoma in 2 cases and hepatocellular carcinoma without chronic liver disease in 1 case. The calculated FLR volume was 289±122 mL (21.1±5.5%) before ALPPS-1 and 528±121 mL (32.2±5.7%) before ALLPS-2 (p<0.001). The increase in FLR between the two procedures was 96±47% (range: 24–160%, p<0.001). Additional interventions were performed in 4 cases: 3 patients underwent Roux-en-Y hepaticojejunostomy, and one case underwent wedge resection of a residual tumor in the FLR. The average time between the first and second step of the procedure was 10.8±2.9 days. The average hospital stay was 24.1±13.3 days. There was 1 postoperative death due to hepatic failure in the oldest patient of this series who had a perihilar cholangiocarcinoma and concomitant liver fibrosis; 11 complications occurred in 6 patients, 4 of whom had grade III or above disease. After a mean follow-up of 17.1±8.5 months, the overall survival was 89% at 3–6 and 12 months. The recurrence-free survival was 100%, 87.5% and 75% at 3-6-12 months respectively. The literature search yielded 148 articles, of which 22 articles published between 2012 and 2015 were included in this systematic review. Conclusion The ALPPS technique effectively increased the

  5. Fluorescence, PRI and canopy temperature for water stress detection in cereal crops

    NASA Astrophysics Data System (ADS)

    Panigada, C.; Rossini, M.; Meroni, M.; Cilia, C.; Busetto, L.; Amaducci, S.; Boschetti, M.; Cogliati, S.; Picchi, V.; Pinto, F.; Marchesi, A.; Colombo, R.

    2014-08-01

    Narrow-band multispectral remote sensing techniques and thermal imagery were investigated for water stress detection in cereal crops. Visible and near infrared AISA Eagle (Specim, Finland) and thermal AHS-160 (Sensytech Inc., USA) imageries were acquired with an airborne survey on a farm-level experimental site where maize (Zea mays L.) and sorghum (Sorghum bicolor L.) were grown with three different irrigation treatments. Vegetation biophysical and eco-physiological measurements were collected concurrently with the airborne campaign. Leaf fluorescence yield (ΔF/Fm‧) resulted to be a good indirect measure of water stress. Therefore, ΔF/Fm‧ measurements were compared against remotely sensed indicators: (i) the Photochemical Reflectance Index (PRI), (ii) the sun-induced chlorophyll fluorescence at 760 nm (F760), retrieved by the Fraunhofer line depth method and (iii) the canopy temperature (TC) calculated decoupling soil and vegetation contributions. TC was related to ΔF/Fm‧ with the highest determination coefficient (R2 = 0.65), followed by PRI586 (reference band at 586 nm) (R2 = 0.51). The relationship with F760 was significant but weaker (R2 = 0.36). The coefficient of determination increased up to 0.54 when pigment concentration was considered by multiplying ΔF/Fm‧ and chlorophyll content, confirming the close relationship between passive fluorescence signal, pigment content and light photosystem efficiency. PRI586, F760 and TC maps were produced in maize and sorghum plots. The differences in the average values of PRI586, F760 and TC extracted from the plots with different water treatments showed that water treatments were well discriminated in maize plots by the three remotely sensed indicators. This was confirmed by the visual observation of the PRI586, F760 and TC maps, while in sorghum plots, F760 and TC appeared more sensitive to water stress compared to PRI586.

  6. Bidirectional processing of pri-miRNAs with branched terminal loops by Arabidopsis Dicer-like1.

    PubMed

    Zhu, Hongliang; Zhou, Yuyi; Castillo-González, Claudia; Lu, Amber; Ge, Chunxiao; Zhao, Ying-Tao; Duan, Liusheng; Li, Zhaohu; Axtell, Michael J; Wang, Xiu-Jie; Zhang, Xiuren

    2013-09-01

    MicroRNAs (miRNAs) originate from primary transcripts (pri-miRNAs) with characteristic stem-loop structures, and their accurate processing is required for the production of functional miRNAs. Here, using the pri-miR-166 family in Arabidopsis thaliana as a paradigm, we report the crucial role of pri-miRNA terminal loops in miRNA biogenesis. We found that multibranched terminal loops in pri-miR-166s substantially suppress miR-166 expression in vivo. Unlike canonical processing of pri-miRNAs, terminal loop-branched pri-miRNAs can be processed by Dicer-like 1 (DCL1) complexes bidirectionally from base to loop and from loop to base, resulting in productive and abortive processing of miRNAs, respectively. In both cases, DCL1 complexes canonically cut pri-miRNAs at a distance of 16-17 bp from a reference single-stranded loop region. DCL1 also adjusts processing sites toward an internal loop through its helicase domain. These results provide new insight into the poorly understood processing mechanism of pri-miRNAs with complex secondary structures.

  7. Non-Respiratory Indications for Polysomnography and Related Procedures in Children: An Evidence-Based Review

    PubMed Central

    Kotagal, Suresh; Nichols, Cynthia D.; Grigg-Damberger, Madeleine M.; Marcus, Carole L.; Witmans, Manisha B.; Kirk, Valerie G.; D'Andrea, Lynn A.; Hoban, Timothy F.

    2012-01-01

    Objective: This evidence-based review provides a systematic and comprehensive review of the literature regarding the utility of polysomnography for the evaluation of non-respiratory sleep disorders in children including hypersomnias, parasomnias, sleep-related movement disorders, and sleep in other special populations. Methods: A task force of pediatric sleep medicine experts performed a systematic review of the literature regarding the use of polysomnography for non-respiratory sleep disorders in children. They identified and graded 76 papers as evidence. Results: The main results include (1) polysomnography combined with the multiple sleep latency test is useful for evaluating disorders of excessive somnolence to objectively quantify sleepiness. The results have to be interpreted with consideration of the pubertal stage and regularity of the sleep patterns of the child; (2) polysomnography is indicated in children with parasomnias or sleep related movement disorders who have a high likelihood of having obstructive sleep apnea (OSA); (3) polysomnography is not routinely indicated in children with enuresis unless there is a high likelihood of OSA; (4) polysomnography can be helpful in evaluating children with restless legs syndrome (RLS) and when periodic limb movement disorder (PLMD) is suspected. Conclusions: These findings suggest that, in children with non-respiratory sleep disorders, polysomnography should be a part of a comprehensive sleep evaluation in selected circumstances to determine the nature of the events in more detail or when the suspicion of OSA is relatively high. Citation: Kotagal S; Nichols CD; Grigg-Damberger MM; Marcus CL; Witmans MB; Kirk VG; D'Andrea LA; Hoban TF. Non-respiratory indications for polysomnography and related procedures in children: an evidence-based review. SLEEP 2012;35(11):1451-1466. PMID:23115394

  8. Lung radiofrequency and microwave ablation: a review of indications, techniques and post-procedural imaging appearances.

    PubMed

    Smith, S L; Jennings, P E

    2015-02-01

    Lung ablation can be used to treat both primary and secondary thoracic malignancies. Evidence to support its use, particularly for metastases from colonic primary tumours, is now strong, with survival data in selected cases approaching that seen after surgery. Because of this, the use of ablative techniques (particularly thermal ablation) is growing and the Royal College of Radiologists predict that the number of patients who could benefit from such treatment may reach in excess of 5000 per year in the UK. Treatment is often limited to larger regional centres, and general radiologists often have limited awareness of the current indications and the techniques involved. Furthermore, radiologists without any prior experience are frequently expected to interpret post-treatment imaging, often performed in the context of acute complications, which have occurred after discharge. This review aims to provide an overview of the current indications for pulmonary ablation, together with the techniques involved and the range of post-procedural appearances.

  9. Lung radiofrequency and microwave ablation: a review of indications, techniques and post-procedural imaging appearances

    PubMed Central

    Jennings, P E

    2015-01-01

    Lung ablation can be used to treat both primary and secondary thoracic malignancies. Evidence to support its use, particularly for metastases from colonic primary tumours, is now strong, with survival data in selected cases approaching that seen after surgery. Because of this, the use of ablative techniques (particularly thermal ablation) is growing and the Royal College of Radiologists predict that the number of patients who could benefit from such treatment may reach in excess of 5000 per year in the UK. Treatment is often limited to larger regional centres, and general radiologists often have limited awareness of the current indications and the techniques involved. Furthermore, radiologists without any prior experience are frequently expected to interpret post-treatment imaging, often performed in the context of acute complications, which have occurred after discharge. This review aims to provide an overview of the current indications for pulmonary ablation, together with the techniques involved and the range of post-procedural appearances. PMID:25465192

  10. Non-invasive anaesthetic methods for dermatological laser procedures: a systematic review.

    PubMed

    Greveling, K; Prens, E P; Liu, L; van Doorn, M B A

    2017-07-01

    Pain is a common side-effect of dermatological laser procedures. Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy. However, it remains unclear which method provides the best pain relief. The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures. A systematic literature search was conducted. Randomized and non-randomized controlled clinical trials (RCTs and CCTs) were included. Two authors independently assessed study eligibility, extracted data and assessed the risk of bias. The quality of evidence was rated using Grading of Recommendations Assessment, Development and Evaluation (GRADE). Twenty RCTs and 12 CCTs were included, involving nine different laser indications: hair removal (n = 9), resurfacing/rejuvenation (n = 5), port wine stains (n = 8), leg telangiectasia (n = 3), facial telangiectasia (n = 2), tattoo removal (n = 2), naevus of Ota (n = 1), solar lentigines (n = 1) and HPV lesions (n = 1). The non-invasive anaesthetic methods (i.e. topical anaesthetic drugs, skin cooling, and pneumatic skin flattening [PSF]), types of lasers, laser settings, application time, and types of pain scales varied widely among the included studies. All of the studies had an unclear or high risk of bias, and the overall quality of evidence was rated as low. In general, active non-invasive anaesthetic methods seemed to provide favourable results compared to placebo or no anaesthesia, and topical anaesthetic drugs and PSF seemed to result in a better pain reduction than skin cooling. However, the current evidence is insufficient to provide recommendations for daily clinical practice. There is a need for more high-quality (head-to-head) RCTs. Future studies should also evaluate sex differences in pain perception, have uniformity with regard to validated pain measurement scales

  11. Are reviews based on sham acupuncture procedures in fibromyalgia syndrome (FMS) valid?

    PubMed

    Lundeberg, Thomas; Lund, Iréne

    2007-09-01

    In recent reviews regarding the efficacy of acupuncture in fibromyalgia syndrome (FMS) it has been concluded that acupuncture has no specific effect since the control procedure (superficial needling and/or needling away from 'specific' points) had similar effects. These conclusions may be questioned since superficial needling and/or needling away from specific trigger points is not inert. Also, manual acupuncture or mild electroacupuncture (EA) may not be sufficient to activate the endogenous pain inhibiting system. Patients with FMS suffer from allodynia, fatigue and muscle ache, which is partly explained by peripheral and central sensitisation. Sensitisation results in augmented and altered stimulus responses whereby light stimulation of the skin has as strong an effect as regular needling on the pain inhibitory system in FMS. Central sensitisation in FMS is also associated with expanded receptive fields of central neurons resulting in a larger topographic distribution of the pain. This would suggest that control procedures using needling away from the 'specific site' might have as strong an effect as needling within the most painful area. Also, repeated nociceptive input from muscles (as obtained by de qi) results in expansion of receptive fields which in turn may result in activation of descending pain inhibition outside the stimulated myotome. Sensitisation to pain, such as in FMS, may also be related to abnormalities in descending efferent pathways. As there is likely to be an imbalance between excitatory and inhibitory systems in FMS, stronger stimulation may therefore be needed to activate the descending pain inhibitory system. In studies using mild manual acupuncture or weak EA stimulation optimal pain inhibition may therefore not have been obtained. When conducting studies on acupuncture, the clinical condition or syndrome needs to be taken into account and the control procedure designed accordingly.

  12. Peroral endoscopic myotomy—initial experience with anesthetic management of 24 procedures and systematic review

    PubMed Central

    Goudra, Basavana; Singh, Preet Mohinder; Gouda, Gowri; Sinha, Ashish C.

    2016-01-01

    Background: Peroral endoscopic myotomy (POEM) is a novel method of treating achalasia of the esophagus. Very little data are available to guide the anesthesia providers caring for these patients. The anesthetic challenges are primarily related to the risk of pulmonary aspiration. There is also a potential risk of pneumomediastinum, pneumoperitoneum, subcutaneous, or submucosal emphysema, as a result of carbon dioxide tracking into the soft tissues surrounding the esophagus and lower esophageal sphincter. Methods: In this retrospective study, electronic charts of 24 patients who underwent POEM over 18 months were reviewed. Demographic data, fasting status, relevant aspiration risks, anesthetic technique, and postoperative care measures were extracted. Results: Fasting times for both solids and liquids were variable. None of the patients underwent preprocedural esophageal emptying. Standard induction and intubation were performed in 16, rapid sequence induction (RSI) with cricoid pressure in seven, and modified rapid sequence without application of cricoid pressure in one of the patients. One of the patients aspirated at induction, and the procedure was aborted. However, the procedure was performed successfully after a few weeks, this time a RSI with cricoid pressure was chosen. Conclusion: As there are no guidelines for the perioperative management of patients presenting for POEM presently, certain recommendations can be made. Preprocedural esophageal emptying should be considered in patients considered as high-risk, although cultural factors might preclude such an approach. Induction and intubation in a semi-reclining position might be useful. Although debatable, use of RSI with cricoid pressure should be strongly considered. PMID:27212764

  13. Micro-invasive glaucoma surgery (MIGS): a review of surgical procedures using stents

    PubMed Central

    Pillunat, Lutz E; Erb, Carl; Jünemann, Anselm GM; Kimmich, Friedemann

    2017-01-01

    Over the last decade several novel surgical treatment options and devices for glaucoma have been developed. All these developments aim to cause as little trauma as possible to the eye, to safely, effectively, and sustainably reduce intraocular pressure (IOP), to produce reproducible results, and to be easy to adopt. The term “micro-invasive glaucoma surgery (MIGS)” was used for summarizing all these procedures. Currently MIGS is gaining more and more interest and popularity. The possible reduction of the number of glaucoma medications, the ab interno approach without damaging the conjunctival tissue, and the probably safer procedures compared to incisional surgical methods may explain the increased interest in MIGS. The use of glaucoma drainage implants for lowering IOP in difficult-to-treat patients has been established for a long time, however, a variety of new glaucoma micro-stents are being manufactured by using various materials and are available to increase aqueous outflow via different pathways. This review summarizes published results of randomized clinical studies and extensive case report series on these devices, including Schlemm’s canal stents (iStent®, iStent® inject, Hydrus), suprachoroidal stents (CyPass®, iStent® Supra), and subconjunctival stents (XEN). The article summarizes the findings of published material on efficacy and safety for each of these approaches. PMID:28919702

  14. Procedures for measuring and verifying gastric tube placement in newborns: an integrative review

    PubMed Central

    Dias, Flávia de Souza Barbosa; Emidio, Suellen Cristina Dias; Lopes, Maria Helena Baena de Moraes; Shimo, Antonieta Keiko Kakuda; Beck, Ana Raquel Medeiros; Carmona, Elenice Valentim

    2017-01-01

    ABSTRACT Objective: to investigate evidence in the literature on procedures for measuring gastric tube insertion in newborns and verifying its placement, using alternative procedures to radiological examination. Method: an integrative review of the literature carried out in the Cochrane, LILACS, CINAHL, EMBASE, MEDLINE and Scopus databases using the descriptors “Intubation, gastrointestinal” and “newborns” in original articles. Results: seventeen publications were included and categorized as “measuring method” or “technique for verifying placement”. Regarding measuring methods, the measurements of two morphological distances and the application of two formulas, one based on weight and another based on height, were found. Regarding the techniques for assessing placement, the following were found: electromagnetic tracing, diaphragm electrical activity, CO2 detection, indigo carmine solution, epigastrium auscultation, gastric secretion aspiration, color inspection, and evaluation of pH, enzymes and bilirubin. Conclusion: the measuring method using nose to earlobe to a point midway between the xiphoid process and the umbilicus measurement presents the best evidence. Equations based on weight and height need to be experimentally tested. The return of secretion into the tube aspiration, color assessment and secretion pH are reliable indicators to identify gastric tube placement, and are the currently indicated techniques. PMID:28699995

  15. Airway Management During Upper GI Endoscopic Procedures: State of the Art Review.

    PubMed

    Goudra, Basavana; Singh, Preet Mohinder

    2017-01-01

    With the growing popularity of propofol mediated deep sedation for upper gastrointestinal (GI) endoscopic procedures, challenges are being felt and appreciated. Research suggests that management of the airway is anything but routine in this setting. Although many studies and meta-analyses have demonstrated the safety of propofol sedation administered by registered nurses under the supervision of gastroenterologists (likely related to the lighter degrees of sedation than those provided by anesthesia providers and is under medicolegal controversy in the United States), there is no agreement on the optimum airway management for procedures such as endoscopic retrograde cholangiopancreatography. Failure to rescue an airway at an appropriate time has led to disastrous consequences. Inability to evaluate and appreciate the risk factors for aspiration can ruin the day for both the patient and the health care providers. This review apprises the reader of various aspects of airway management relevant to the practice of sedation during upper GI endoscopy. New devices and modification of existing devices are discussed in detail. Recognizing the fact that appropriate monitoring is important for timely recognition and management of potential airway disasters, these issues are explored thoroughly.

  16. High-density polytetrafluoroethylene membranes in guided bone and tissue regeneration procedures: a literature review.

    PubMed

    Carbonell, J M; Martín, I Sanz; Santos, A; Pujol, A; Sanz-Moliner, J D; Nart, J

    2014-01-01

    Expanded polytetrafluoroethylene (e-PTFE) has been used successfully as a membrane barrier for regeneration procedures. However, when exposed to the oral cavity, its high porosity increases the risk of early infection, which can affect surgical outcomes. An alternative to e-PTFE is non-expanded and dense polytetrafluoroethylene (n-PFTE), which results in lower levels of early infection following surgical procedures. The aim of this literature review was to analyze and describe the available literature on n-PFTE, report the indications for use, advantages, disadvantages, surgical protocols, and complications. The medical databases Medline-PubMed and Cochrane Library were searched and supplemented with a hand search for reports published between 1980 and May 2012 on n-PTFE membranes. The search strategy was limited to animal, human, and in vitro studies in dental journals published in English. Twenty-four articles that analyzed the use of n-PTFE as a barrier membrane for guided tissue regeneration and guided bone regeneration around teeth and implants were identified: two in vitro studies, seven experimental studies, and 15 clinical studies. There is limited clinical and histological evidence for the use of n-PTFE membranes at present, with some indications in guided tissue regeneration and guided bone regeneration in immediate implants and fresh extraction sockets.

  17. Patient outcomes and procedure working time for digital versus conventional impressions: A systematic review.

    PubMed

    Gallardo, Yolanda R; Bohner, Lauren; Tortamano, Pedro; Pigozzo, Monica N; Laganá, Dalva C; Sesma, Newton

    2017-09-27

    Limited evidence is available comparing digital versus conventional impressions from the point of view of patient preference. The purpose of this systematic review was to identify and summarize the available literature related to patient-centered outcomes for digital versus conventional impression techniques. The databases Medline, Cochrane, Science Direct, Scopus, and Embase were electronically searched and complemented by hand searches. All published papers available on the databases from 1955 to July 2016 were considered for title and abstract analysis. A total of 2943 articles were initially identified through database searches, of which only 5 met the inclusion criteria for qualitative analysis. Four studies comparing patient-reported outcome measures (PROMs) between conventional and digital impressions revealed that the digital technique was more comfortable and caused less anxiety and sensation of nausea. Only 1 study reported no difference between the techniques regardless of patient comfort. Two studies reported a shorter procedure for the conventional technique, whereas 3 studies reported a shorter procedure for the digital technique. A lack of clinical studies addressing patient outcomes regarding digital prosthodontic treatments was observed among the included articles. However, current evidence suggests that patients are more likely to prefer the digital workflow than the conventional techniques. Copyright © 2017 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  18. Regulation of pri-miRNA processing by the hnRNP-like protein AtGRP7 in Arabidopsis.

    PubMed

    Köster, Tino; Meyer, Katja; Weinholdt, Claus; Smith, Lisa M; Lummer, Martina; Speth, Corinna; Grosse, Ivo; Weigel, Detlef; Staiger, Dorothee

    2014-09-01

    The hnRNP-like glycine-rich RNA-binding protein AtGRP7 regulates pre-mRNA splicing in Arabidopsis. Here we used small RNA-seq to show that AtGRP7 also affects the miRNA inventory. AtGRP7 overexpression caused a significant reduction in the level of 30 miRNAs and an increase for 14 miRNAs with a minimum log2 fold change of ± 0.5. Overaccumulation of several pri-miRNAs including pri-miR398b, pri-miR398c, pri-miR172b, pri-miR159a and pri-miR390 at the expense of the mature miRNAs suggested that AtGRP7 affects pri-miRNA processing. Indeed, RNA immunoprecipitation revealed that AtGRP7 interacts with these pri-miRNAs in vivo. Mutation of an arginine in the RNA recognition motif abrogated in vivo binding and the effect on miRNA and pri-miRNA levels, indicating that AtGRP7 inhibits processing of these pri-miRNAs by direct binding. In contrast, pri-miRNAs of selected miRNAs that were elevated or not changed in response to high AtGRP7 levels were not bound in vivo. Reduced accumulation of miR390, an initiator of trans-acting small interfering RNA (ta-siRNA) formation, also led to lower TAS3 ta-siRNA levels and increased mRNA expression of the target AUXIN RESPONSE FACTOR4. Furthermore, AtGRP7 affected splicing of pri-miR172b and pri-miR162a. Thus, AtGRP7 is an hnRNP-like protein with a role in processing of pri-miRNAs in addition to its role in pre-mRNA splicing. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  19. Neuropathic Pain Post Spinal Cord Injury Part 2: Systematic Review of Dorsal Root Entry Zone Procedure

    PubMed Central

    2013-01-01

    Background: Pharmacotherapy may not sufficiently reduce neuropathic pain in many individuals post spinal cord injury (SCI). The use of alternative therapies such as surgery may be effective in reducing neuropathic pain in these individuals. However, because of the invasive nature of surgery, it is important to examine the evidence for use of this treatment. Objective: The purpose of this study was to conduct a systematic review of published literature on the surgical treatment of neuropathic pain after SCI. Methods: MEDLINE, CINAHL, EMBASE, and PsycINFO databases were searched for articles in which surgical treatment of pain after SCI was examined. Articles were restricted to the English language. Article selection was conducted by 2 independent reviewers with the following inclusion criteria: the subjects participated in a surgical intervention for neuropathic pain; at least 50% of the subjects had an SCI; at least 3 subjects had an SCI; and a definable intervention involving the dorsal root entry zone (DREZ) procedure was used to reduce pain. Data extracted included study design, study type, subject demographics, inclusion and exclusion criteria, sample size, outcome measures, and study results. Randomized controlled trials (RCTs) were assessed for quality using the Physiotherapy Evidence Database (PEDro) assessment scale. Levels of evidence were assigned to each intervention using a modified Sackett scale. Results: Eleven studies met the inclusion criteria. One study provided level 2 evidence, and the rest provided level 4 evidence. The DREZ procedure was shown to be more effective for segmental pain than for diffuse pain after SCI. Further, individuals with conus medullaris level injury were found to have a higher level of neuropathic pain relief than those with cervical, thoracic, or cauda equina injury. Conclusions: The studies demonstrated that the DREZ procedure may be effective in reducing segmental pain. Hence, DREZ may be important in treatment of

  20. [Complementary and alternative procedures for fibromyalgia syndrome : Updated guidelines 2017 and overview of systematic review articles].

    PubMed

    Langhorst, J; Heldmann, P; Henningsen, P; Kopke, K; Krumbein, L; Lucius, H; Winkelmann, A; Wolf, B; Häuser, W

    2017-06-01

    The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was scheduled for April 2017. The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest. A search of the literature for systematic reviews of randomized controlled trials of complementary and alternative therapies from December 2010 to May 2016 was performed in the Cochrane library, MEDLINE, PsycINFO and Scopus databases. Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine version 2009. The strength of recommendations was formed by multiple step formalized procedures to reach a consensus. Efficacy, risks, patient preferences and applicability of available therapies were weighed up against each other. The guidelines were reviewed and approved by the board of directors of the societies engaged in the development of the guidelines. Meditative movement therapies (e.g. qi gong, tai chi and yoga) are strongly recommended. Acupuncture and weight reduction in cases of obesity can be considered.

  1. Effectiveness of sinus lift procedures for dental implant rehabilitation: a Cochrane systematic review.

    PubMed

    Esposito, Marco; Grusovin, Maria Gabriella; Rees, Jonathan; Karasoulos, Dimitrios; Felice, Pietro; Alissa, Rami; Worthington, Helen; Coulthard, Paul

    2010-01-01

    Marco Esposito, Pietro Felice and Paul Coulthard are among the authors of four of the included trials, however, they were not involved in the quality assessment of these trials. This review is based on a Cochrane systematic review entitled 'Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus' published in The Cochrane Library (see http:// www.cochrane.org/ for information). Cochrane systematic reviews are regularly updated to include new research and in response to comments and criticisms from readers. If you wish to comment on this review, please send your comments to the Cochrane website or to Marco Esposito. The Cochrane Library should be consulted for the most recent version of the review. The results of a Cochrane Review can be interpreted differently, depending on people's perspectives and circumstances. Please consider the conclusions presented carefully. They are the opinions of the review authors, and are not necessarily shared by the Cochrane Collaboration. Insufficient bone volume is a common problem encountered in the rehabilitation of the edentulous posterior maxillae with implant supported prostheses. Bone volume is limited by the presence of the maxillary sinus together with loss of alveolar bone height. Sinus lift procedures increase bone volume by augmenting the sinus cavity with autogenous bone and/or commercially available biomaterials. To test whether and when augmentation of the maxillary sinus is necessary and which are the most effective augmentation techniques for rehabilitating patients with implant-supported prostheses. The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched. Several dental journals were hand searched. The bibliographies of review articles were checked, and personal references were searched. More than 55 implant manufacturing companies were also contacted. The last electronic search was conducted

  2. Changes in Gastrointestinal Hormones and Leptin after Roux-en-Y Gastric Bypass Procedure: A Review

    PubMed Central

    BECKMAN, LAUREN M.; BECKMAN, TIFFANY R.; EARTHMAN, CARRIE P.

    2014-01-01

    Roux-en-Y gastric bypass is a well-accepted tool for the treatment of obesity and, compared to conventional weight loss methods (eg, diet and exercise) and other weight loss surgeries (eg, gastric banding), it results in considerable weight loss that is maintained long term. Although successful, the mechanisms for weight loss are not completely understood and it is thought that gastrointestinal hormones play a role. Several gastrointestinal hormones have been identified for their effects on appetite, including glucagon-like peptide-1 (GLP-1), peptide tyrosine-tyrosine (PYY), leptin, and ghrelin. This review encompasses a literature search that included 45 primary articles and shows that there are alterations in GLP-1, PYY, leptin, and ghrelin postoperatively. GLP-1 and PYY concentrations were usually found to be higher, whereas ghrelin levels were typically lower post- Roux-en-Y gastric bypass than in individuals with obesity, those who were overweight or of normal weight, and in those who underwent procedures other than Roux-en-Y gastric bypass or who achieved weight loss by lifestyle modification. An understanding of how gastrointestinal hormones change after Roux-en-Y gastric bypass may help dietetics practitioners optimize nutrition care for this patient population. A review of the literature also highlighted some research gaps that should be taken into consideration when designing future studies. PMID:20338283

  3. The procedures used to review safety analysis reports for packagings submitted to the US Department of Energy for certification

    SciTech Connect

    Popper, G.F.; Raske, D.T.; Turula, P.

    1988-01-01

    This paper presents an overview of the procedures used at the Argonne National Laboratory (ANL) to review Safety Analysis Reports for Packagings (SARPs) submitted to the US Department of Energy (DOE) for issuance of a Certificate of Compliance. Prior to certification and shipment of a packaging for the transport of radioactive materials, a SARP must be prepared describing the design, contents, analyses, testing, and safety features of the packaging. The SARP must be reviewed to ensure that the specific packaging meets all DOE orders and federal regulations for safe transport. The ANL SARP review group provides an independent review and evaluation function for the DOE to ensure that the packaging meets all the prescribed requirements. This review involves many disciplines and includes evaluating the general information, drawings, construction details, operating procedures, maintenance and test programs, and the quality assurance plan for compliance with requirements. 14 refs., 6 figs.

  4. Intranasal ketamine for procedural sedation and analgesia in children: A systematic review

    PubMed Central

    2017-01-01

    Background Ketamine is commonly used for procedural sedation and analgesia (PSA) in children. Evidence suggests it can be administered intranasally (IN). We sought to review the evidence for IN ketamine for PSA in children. Methods We performed a systematic review of randomized trials of IN ketamine in PSA that reported any sedation-related outcome in children 0 to 19 years. Trials were identified through electronic searches of MEDLINE (1946–2016), EMBASE (1947–2016), Google Scholar (2016), CINAHL (1981–2016), The Cochrane Library (2016), Web of Science (2016), Scopus (2016), clinical trial registries, and conference proceedings (2000–2016) without language restrictions. The methodological qualities of studies and the overall quality of evidence were evaluated using the Cochrane Collaboration’s Risk of Bias tool, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, respectively. Results The review included 7 studies (n = 264) of children ranging from 0 to 14 years. Heterogeneity in study design precluded meta-analysis. Most studies were associated with a low or unclear risk of bias and outcome-specific ratings for quality of evidence were low or very low. In four of seven studies, IN ketamine provided superior sedation to comparators and resulted in adequate sedation for 148/175 (85%) of participants. Vomiting was the most common adverse effect; reported by 9/91 (10%) of participants. Conclusions IN ketamine administration is well tolerated and without serious adverse effects. Although most participants were deemed adequately sedated with IN ketamine, effectiveness of sedation with respect to superiority over comparators was inconsistent, precluding a recommendation for PSA in children. PMID:28319161

  5. Use and implementation of standard operating procedures and checklists in prehospital emergency medicine: a literature review.

    PubMed

    Chen, Chulin; Kan, Ting; Li, Shuang; Qiu, Chen; Gui, Li

    2016-12-01

    This review aimed to analyze published literature to introduce the use and implementation of standard operating procedures (SOPs) and checklists in prehospital emergency medicine and their impact on guideline adherence and patient outcome. An English literature search was carried out using the Cochrane Library, MEDLINE, EMBASE, Springer, Elsevier, and ProQuest databases. Original articles describing the use and implementation of SOPs or checklists in prehospital emergency medicine were included. Editorials, comments, letters, bulletins, news articles, conference abstracts, and notes were excluded from the analysis. Relevant information was extracted relating to application areas, development of SOPs/checklists, educational preparation and training regarding SOPs/checklists implementation, staff attitudes and the effects of SOPs/checklists use on guideline adherence and patient outcomes. The literature search found 2187 potentially relevant articles, which were narrowed down following an abstract review and a full text review. A final total of 13 studies were identified that described the use and implementation of SOPs (9 studies) and checklists (4 studies) in different areas of prehospital emergency medicine including prehospital management of patients with acute exacerbated chronic obstructive pulmonary disease and acute coronary syndrome, prehospital airway management, medical documentation, Emergency Medical Services triage, and transportation of patients. The use and implementation of SOPs and checklists in prehospital emergency medicine have shown some benefits of improving guidelines adherence and patient outcomes in airway management, patient records, identification and triage, and other prehospital interventions. More research in this area is necessary to optimize the future use and implementation of SOPs and checklists to improve emergency personnel performance and patient outcomes. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Formalising multidisciplinary peer review: developing a haematological malignancy-specific electronic proforma and standard operating procedure to facilitate procedural efficiency and evidence-based clinical practice.

    PubMed

    Trotman, Judith; Trinh, Jimmy; Kwan, Yiu Lam; Estell, Jane A; Fletcher, Julie; Archer, Kate; Lee, Kenneth; Foo, Kerwin; Curnow, Jennifer; Bianchi, Alessandra; Wignall, Lynda; Verner, Emma; Gasiorowski, Robin; Siedlecka, Elizabeth; Cunningham, Ilona

    2017-05-01

    Multidisciplinary team (MDT) meetings aimed at facilitating peer review have become standard practice in oncology. However, there is scant literature on the optimal structure and conduct of such meetings. To develop a process for formal peer review of patients with haematological malignancies and to audit any resulting changes made to the management recommendations of the treating physician. A standard operating procedure (SOP) for MDT meetings was developed essentially to integrate clinical peer review with weekly pathology and radiology meetings. The centrepiece is the electronic submission of a patient-specific proforma (Microsoft InfoPath) prior to the meeting. It serves as the template for presentation, discussion and recording of recommendations and conclusions. The final verified document is stored in the electronic patient record, and a copy is sent to the general practitioner. The proposed management plans were compared to the consensus recommendations of the meeting for the first 4 years since inception. Both SOP and proforma underwent continual improvements. These provided the framework for the conduct of a robust weekly MDT meeting for peer review of the management of patients with haematological malignancies. On 20% of occasions, patient management plans were altered to optimise patient care as a direct consequence on peer review at the MDT. Our streamlined process, in its ultimate format, has provided a mature and efficient forum for formal peer review in a genuine multidisciplinary environment. Both initial data and informal feedback support its ongoing activity as an integral component of delivering quality patient care. © 2016 Royal Australasian College of Physicians.

  7. Shoulder Structure and Function Following the Modified Latarjet Procedure: A Clinical and Radiological Review

    PubMed Central

    Garewal, Devinder; Evans, Mathew; Taylor, David; Hoy, Gregory A.; Barwood, Shane; Connell, David

    2013-01-01

    Background To evaluate the clinical and radiological outcomes of the modified Latarjet procedure for traumatic, antero-inferior glenohumeral joint instability. Methods Case series were used with a mean follow-up of 21.3 months for clinical and radiological review and 47.2 months for recurrent instability. Shoulder function was evaluated by clinical examination and validated shoulder scales: Western Ontario Shoulder Stability Index (WOSI), Melbourne Instability Shoulder Score (MISS) and l'Insalata Shoulder Questionnaire. Shoulder structure was evaluated by computed tomography. Results Thirty-two cases were enrolled (mean age 27.0 years). One patient reported a redislocation during the follow-up period. Clinical examination revealed that the median external rotation (at 0° and 90° abduction) was reduced on the operative side by 7.5° (p < 0.01) and 10° (p < 0.001), respectively. Subjective shoulder function was good. Mean (SD) scores on the WOSI, MISS and l'Insalata scales were 78.0 (19.7), 75.8 (11.5) and 89.3 (9.9), respectively. No loss of subscapularis strength was identified (p > 0.05). Radiological evaluation revealed a mean (SD) pre-operative glenoid surface area loss of 169.5 (48.5) mm2 reconstituted surgically by a bone block of 225.4 (73.8) mm2. Subscapularis muscle bulk was reduced on the operative side, above the level of the muscle split (p < 0.05). Conclusions The Latarjet procedure reliably restores lost glenoid surface area, shoulder stability, strength and function. A small loss of external rotation is expected and related to altered subscapularis anatomy. PMID:27582905

  8. A Proposal for a New Arteriovenous Malformation Grading Scale for Neuroendovascular Procedures and Literature Review

    PubMed Central

    Feliciano, Caleb E.; León-Berra, Ramón de; Hernandez-Gaitán, Manuel S.; Rodríguez-Mercado, Rafael

    2011-01-01

    Background Traditionally, decisions regarding treatment and outcomes for patients with cerebral arteriovenous malformations have made use of the Spetzler-Martin grading scale. The latter has withstood the test of time in clinical practice for AVM patients managed surgically and even when comparing studies involving other modalities of treatment. Recent awareness on the applicability of the grading system for risk assessment and outcome determination in cases of treatment by neuroendovascular means has emerged. We propose a similar grading system for neuroendovascular procedures based on a revision of the available literature. Methods A literature search using the keywords ‘arteriovenous malformation’, ‘embolization’ and ‘outcome’ was done. Articles studying the factors involved in complications and outcome determination for endovascular cerebral AVM patients were reviewed. These were tabulated and those dealing with anatomical, radiological and hemodynamic descriptions that were noted as significant determinants of risk or clinical outcome were used for development of a grading system. Results A grading system similar to the Spetzler-Martin grading scale was developed using factors deemed in the literature as significant determinants of outcome. The classification includes the number of feeding vessels into the AVM, the eloquence of adjacent areas, and the presence of fistulous components. Follow up studies are underway at our institution to validate our proposal. Yet, significant evidence exists in the literature validating those factors as stand alone determinants of outcome and risk, suggesting that this grading scale may well be applicable to endovascular embolization procedures. Conclusions A grading scale similar to the Spetzler-Martin grading system for use in risk assessment and outcome determination in brain AVM patients treated by endovascular means seems adequate and clinically feasible. Studies on applicability and validation are underway

  9. A proposal for a new arteriovenous malformation grading scale for neuroendovascular procedures and literature review.

    PubMed

    Feliciano, Caleb E; de León-Berra, Ramón; Hernández-Gaitán, Manuel S; Rodríguez-Mercado, Rafael

    2010-06-01

    Traditionally, decisions regarding treatment and outcomes for patients with cerebral arteriovenous malformations (AVM) have made use of the Spetzler-Martin grading scale. The latter has withstood the test of time in clinical practice for AVM patients managed surgically and even when comparing studies involving other modalities of treatment. Recent awareness on the applicability of the grading system for risk assessment and outcome determination in cases of treatment by neuroendovascular means has emerged. We propose a preliminary grading system for neuroendovascular procedures based on a revision of the available literature. A literature search using the keywords 'arteriovenous malformation', 'embolization' and 'outcome' was done. Articles studying the factors involved in complications and outcome determination for endovascular cerebral AVM patients were reviewed. These were tabulated and those dealing with anatomical, radiological and hemodynamic descriptions that were noted as significant determinants of risk or clinical outcome were used for development of a preliminary grading system to be used in a follow-up validation study. A grading system similar to the Spetzler-Martin grading scale was developed using factors deemed in the literature as significant determinants of outcome. The classification includes the number of feeding vessels into the AVM, the eloquence of adjacent areas, and the presence of fistulous components. Follow-up study is underway at our institution to validate our proposal. Yet, significant evidence exists in the literature validating those factors as stand alone determinants of outcome and risk, suggesting that this grading scale may well be applicable to endovascular embolization procedures. A grading scale similar to the Spetzler-Martin grading system for use in risk assessment and outcome determination in brain AVM patients treated by endovascular techniques seems adequate and clinically feasible. Studies on applicability and validation

  10. Diurnal and directional responses of chlorophyll fluorescence and pri in a cornfield

    USDA-ARS?s Scientific Manuscript database

    Two high spectral resolution reflectance-based indices were used to assess whether vegetation in a cornfield was performing near-optimally or exhibiting symptoms of environmental stress. These were the Photochemical Reflectance Index (PRI) and solar-induced Chlorophyll Fluorescence (SIF). This study...

  11. Pri sORF peptides induce selective proteasome-mediated protein processing.

    PubMed

    Zanet, J; Benrabah, E; Li, T; Pélissier-Monier, A; Chanut-Delalande, H; Ronsin, B; Bellen, H J; Payre, F; Plaza, S

    2015-09-18

    A wide variety of RNAs encode small open-reading-frame (smORF/sORF) peptides, but their functions are largely unknown. Here, we show that Drosophila polished-rice (pri) sORF peptides trigger proteasome-mediated protein processing, converting the Shavenbaby (Svb) transcription repressor into a shorter activator. A genome-wide RNA interference screen identifies an E2-E3 ubiquitin-conjugating complex, UbcD6-Ubr3, which targets Svb to the proteasome in a pri-dependent manner. Upon interaction with Ubr3, Pri peptides promote the binding of Ubr3 to Svb. Ubr3 can then ubiquitinate the Svb N terminus, which is degraded by the proteasome. The C-terminal domains protect Svb from complete degradation and ensure appropriate processing. Our data show that Pri peptides control selectivity of Ubr3 binding, which suggests that the family of sORF peptides may contain an extended repertoire of protein regulators. Copyright © 2015, American Association for the Advancement of Science.

  12. Potential relative increment (PRI): a new method to empirically derive optimal tree diameter growth

    Treesearch

    Don C Bragg

    2001-01-01

    Potential relative increment (PRI) is a new method to derive optimal diameter growth equations using inventory information from a large public database. Optimal growth equations for 24 species were developed using plot and tree records from several states (Michigan, Minnesota, and Wisconsin) of the North Central US. Most species were represented by thousands of...

  13. Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.

    PubMed

    Zhang, Junjie; Huang, Xuewen; Xiao, Juanjuan; Yang, Yajun; Zhou, Yinghui; Wang, Xiaofeng; Liu, Qingmei; Yang, Jingmin; Wang, Mengyun; Qiu, Lixin; Zheng, Yabiao; Zhang, Ping; Li, Jin; Wang, Ya'nong; Wei, Qingyi; Jin, Li; Wang, Jiucun; Wang, Minghua

    2014-01-01

    MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43-0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS. p = 0.007, OR = 0.82, 95% CI = 0.71-0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.

  14. Photosynthetic Efficiency of Northern Forest Ecosystems Using a MODIS-Derived Photochemical Reflectance Index (PRI)

    NASA Technical Reports Server (NTRS)

    Middleton, E. M.; Huemmrich, K. F.; Landis, D. R.; Black, T. A.; Barr, A. G.; McCaughey, J. H.

    2016-01-01

    This study evaluates a direct remote sensing approach from space for the determination of ecosystem photosynthetic light use efficiency (LUE), through measurement of vegetation reflectance changes expressed with the Photochemical Reflectance Index (PRI). The PRI is a normalized difference index based on spectral changes at a physiologically active wavelength (approximately 531 nanometers) as compared to a reference waveband, and is only available from a very few satellites. These include the two Moderate-Resolution Imaging Spectroradiometers (MODIS) on the Aqua and Terra satellites each of which have a narrow (10-nanometer) ocean band centered at 531 nanometers. We examined several PRI variations computed with candidate reference bands, since MODIS lacks the traditional 570-nanometer reference band. The PRI computed using MODIS land band 1 (620-670 nanometers) gave the best performance for daily LUE estimation. Through rigorous statistical analyses over a large image collection (n equals 420), the success of relating in situ daily tower-derived LUE to MODIS observations for northern forests was strongly influenced by satellite viewing geometry. LUE was calculated from CO2 fluxes (moles per moles of carbon absorbed quanta) measured at instrumented Canadian Carbon Program flux towers in four Canadian forests: a mature fir site in British Columbia, mature aspen and black spruce sites in Saskatchewan, and a mixed deciduous/coniferous forest site in Ontario. All aspects of the viewing geometry had significant effects on the MODIS-PRI, including the view zenith angle (VZA), the view azimuth angle, and the displacement of the view azimuth relative to the solar principal plane, in addition to illumination related variables.Nevertheless, we show that forward scatter sector views (VZA, 16 degrees-45 degrees) provided the strongest relationships to daily LUE, especially those collected in the early afternoon by Aqua (r squared = 0.83, RMSE (root mean square error) equals 0

  15. Prion-like Nanofibrils of Small Molecules (PriSM) Selectively Inhibit Cancer Cells by Impeding Cytoskeleton Dynamics*

    PubMed Central

    Kuang, Yi; Long, Marcus J. C.; Zhou, Jie; Shi, Junfeng; Gao, Yuan; Xu, Chen; Hedstrom, Lizbeth; Xu, Bing

    2014-01-01

    Emerging evidence reveals that prion-like structures play important roles to maintain the well-being of cells. Although self-assembly of small molecules also affords prion-like nanofibrils (PriSM), little is known about the functions and mechanisms of PriSM. Previous works demonstrated that PriSM formed by a dipeptide derivative selectively inhibiting the growth of glioblastoma cells over neuronal cells and effectively inhibiting xenograft tumor in animal models. Here we examine the protein targets, the internalization, and the cytotoxicity pathway of the PriSM. The results show that the PriSM selectively accumulate in cancer cells via macropinocytosis to impede the dynamics of cytoskeletal filaments via promiscuous interactions with cytoskeletal proteins, thus inducing apoptosis. Intriguingly, Tau proteins are able to alleviate the effect of the PriSM, thus protecting neuronal cells. This work illustrates PriSM as a new paradigm for developing polypharmacological agents that promiscuously interact with multiple proteins yet result in a primary phenotype, such as cancer inhibition PMID:25157102

  16. Association of a peptoid ligand with the apical loop of pri-miR-21 inhibits cleavage by Drosha.

    PubMed

    Diaz, Jason P; Chirayil, Rachel; Chirayil, Sara; Tom, Martin; Head, Katie J; Luebke, Kevin J

    2014-04-01

    We have found a small molecule that specifically inhibits cleavage of a precursor to the oncogenic miRNA, miR-21, by the microprocessor complex of Drosha and DGCR8. We identified novel ligands for the apical loop of this precursor from a screen of 14,024 N-substituted oligoglycines (peptoids) in a microarray format. Eight distinct compounds with specific affinity were obtained, three having affinities for the targeted loop in the low micromolar range and greater than 15-fold discrimination against a closely related hairpin. One of these compounds completely inhibits microprocessor cleavage of a miR-21 primary transcript at concentrations at which cleavage of another miRNA primary transcript, pri-miR-16, is little affected. The apical loop of pri-miR-21, placed in the context of pri-miR-16, is sufficient for inhibition of microprocessor cleavage by the peptoid. This compound also inhibits cleavage of pri-miR-21 containing the pri-miR-16 apical loop, suggesting an additional site of association within pri-miR-21. The reported peptoid is the first example of a small molecule that inhibits microprocessor cleavage by binding to the apical loop of a pri-miRNA.

  17. Association of a peptoid ligand with the apical loop of pri-miR-21 inhibits cleavage by Drosha

    PubMed Central

    Diaz, Jason P.; Chirayil, Rachel; Chirayil, Sara; Tom, Martin; Head, Katie J.; Luebke, Kevin J.

    2014-01-01

    We have found a small molecule that specifically inhibits cleavage of a precursor to the oncogenic miRNA, miR-21, by the microprocessor complex of Drosha and DGCR8. We identified novel ligands for the apical loop of this precursor from a screen of 14,024 N-substituted oligoglycines (peptoids) in a microarray format. Eight distinct compounds with specific affinity were obtained, three having affinities for the targeted loop in the low micromolar range and greater than 15-fold discrimination against a closely related hairpin. One of these compounds completely inhibits microprocessor cleavage of a miR-21 primary transcript at concentrations at which cleavage of another miRNA primary transcript, pri-miR-16, is little affected. The apical loop of pri-miR-21, placed in the context of pri-miR-16, is sufficient for inhibition of microprocessor cleavage by the peptoid. This compound also inhibits cleavage of pri-miR-21 containing the pri-miR-16 apical loop, suggesting an additional site of association within pri-miR-21. The reported peptoid is the first example of a small molecule that inhibits microprocessor cleavage by binding to the apical loop of a pri-miRNA. PMID:24497550

  18. Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.

    PubMed

    Kuang, Yi; Long, Marcus J C; Zhou, Jie; Shi, Junfeng; Gao, Yuan; Xu, Chen; Hedstrom, Lizbeth; Xu, Bing

    2014-10-17

    Emerging evidence reveals that prion-like structures play important roles to maintain the well-being of cells. Although self-assembly of small molecules also affords prion-like nanofibrils (PriSM), little is known about the functions and mechanisms of PriSM. Previous works demonstrated that PriSM formed by a dipeptide derivative selectively inhibiting the growth of glioblastoma cells over neuronal cells and effectively inhibiting xenograft tumor in animal models. Here we examine the protein targets, the internalization, and the cytotoxicity pathway of the PriSM. The results show that the PriSM selectively accumulate in cancer cells via macropinocytosis to impede the dynamics of cytoskeletal filaments via promiscuous interactions with cytoskeletal proteins, thus inducing apoptosis. Intriguingly, Tau proteins are able to alleviate the effect of the PriSM, thus protecting neuronal cells. This work illustrates PriSM as a new paradigm for developing polypharmacological agents that promiscuously interact with multiple proteins yet result in a primary phenotype, such as cancer inhibition.

  19. Tertiary structure mapping of the pri-miRNA miR-17~92.

    PubMed

    Chaulk, Steven G; Fahlman, Richard P

    2014-01-01

    The understanding of RNA in regulating gene expression has exploded over the past 15 years. MicroRNAs (miRNAs) have vastly expanded the role of RNA in gene regulation beyond spliceosomal, ribosomal, and messenger RNAs. Approximately one half of miRNAs are polycistronic, where two or more miRNAs are encoded on a single pri-miRNA transcript, termed a miRNA cluster. The six miRNAs of the miR-17~92 cluster are contained within a ~800 nucleotide region within intron 3 of the cl13orf25 ~7 kb pri-miRNA transcript. We recently reported on the tertiary structured domain of miR-17~92 and its role in modulating miRNA biogenesis. The key finding was that the cluster structure explained the differential processing of the miRNA hairpins by Drosha. This work demonstrated the need to consider pri-miRNA tertiary structure in miRNA biogenesis. Since biochemical structure probing is typically performed on relatively short RNAs (≤200 nucleotides), we had to adapt these methodologies for application on large RNAs (~800 nucleotide miR-17~92 pri-miRNA). We present here our adaptation of a protection footprinting method using ribonucleases to probe the structure of the ~800 nucleotide miR-17~92 pri-miRNA. We outline the technical difficulties involved in probing large RNAs and data visualization using denaturing polyacrylamide gel electrophoresis and how we adapted the existing approaches to probe large RNAs. The methodology outlined here is generally applicable to large RNAs including long noncoding RNAs (lncRNA).

  20. Heavy Metal and Trace Metal Analysis in Soil by Sequential Extraction: A Review of Procedures

    PubMed Central

    Zimmerman, Amanda Jo; Weindorf, David C.

    2010-01-01

    Quantification of heavy and trace metal contamination in soil can be arduous, requiring the use of lengthy and intricate extraction procedures which may or may not give reliable results. Of the many procedures in publication, some are designed to operate within specific parameters while others are designed for more broad application. Most procedures have been modified since their inception which creates ambiguity as to which procedure is most acceptable in a given situation. For this study, the Tessier, Community Bureau of Reference (BCR), Short, Galán, and Geological Society of Canada (GCS) procedures were examined to clarify benefits and limitations of each. Modifications of the Tessier, BCR, and GCS procedures were also examined. The efficacy of these procedures is addressed by looking at the soils used in each procedure, the limitations, applications, and future of sequential extraction. PMID:20414344

  1. A systematic review on diagnostic procedures for specific language impairment: The sensitivity and specificity issues.

    PubMed

    Shahmahmood, Toktam Maleki; Jalaie, Shohreh; Soleymani, Zahra; Haresabadi, Fatemeh; Nemati, Parvin

    2016-01-01

    Identification of children with specific language impairment (SLI) has been viewed as both necessity and challenge. Investigators and clinicians use different tests and measures for this purpose. Some of these tests/measures have good psychometric properties, but it is not sufficient for diagnostic purposes. A diagnostic procedure can be used for identification a specific population with confidence only when its sensitivity and specificity are acceptable. In this study, we searched for tests/measures with predefined sensitivity and specificity for identification of preschool children with SLI from their typically developing peers. A computerized search in bibliographic databases from 2000 to August 2015 was performed with the following keywords: "specific language impairment" or SLI" and "primary language impairment" or 'PLI' with at least one of the followings: "diagnosis," "identification," "accuracy," "sensitivity," and "specificity." In addition, the related citations and reference lists of the selected articles were considered. The results of reviewing 23 included studies show that the index measures used in studies vary in accuracy with the sensitivity ranging from 16% to 100% and the specificity ranging from 14% to 100%. These varieties in sensitivity and specificity of different tests/measures confirm the necessity of attention to the diagnostic power of tests/measures before their use as diagnostic tool. Further, the results indicate there are some promising tests/measures that the available evidence supports their performances in the diagnosis of SLI in preschool-aged children, yet the place of a reference standard for the diagnosis of SLI is vacant among investigations.

  2. Bilateral symmetry in vision and influence of ocular surgical procedures on binocular vision: A topical review.

    PubMed

    Arba Mosquera, Samuel; Verma, Shwetabh

    2016-01-01

    We analyze the role of bilateral symmetry in enhancing binocular visual ability in human eyes, and further explore how efficiently bilateral symmetry is preserved in different ocular surgical procedures. The inclusion criterion for this review was strict relevance to the clinical questions under research. Enantiomorphism has been reported in lower order aberrations, higher order aberrations and cone directionality. When contrast differs in the two eyes, binocular acuity is better than monocular acuity of the eye that receives higher contrast. Anisometropia has an uncommon occurrence in large populations. Anisometropia seen in infancy and childhood is transitory and of little consequence for the visual acuity. Binocular summation of contrast signals declines with age, independent of inter-ocular differences. The symmetric associations between the right and left eye could be explained by the symmetry in pupil offset and visual axis which is always nasal in both eyes. Binocular summation mitigates poor visual performance under low luminance conditions and strong inter-ocular disparity detrimentally affects binocular summation. Considerable symmetry of response exists in fellow eyes of patients undergoing myopic PRK and LASIK, however the method to determine whether or not symmetry is maintained consist of comparing individual terms in a variety of ad hoc ways both before and after the refractive surgery, ignoring the fact that retinal image quality for any individual is based on the sum of all terms. The analysis of bilateral symmetry should be related to the patients' binocular vision status. The role of aberrations in monocular and binocular vision needs further investigation.

  3. Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio

    SciTech Connect

    Liebschner, Dorothee; Brzezinski, Krzysztof; Dauter, Miroslawa; Dauter, Zbigniew; Nowak, Marta; Kur, Józef; Olszewski, Marcin

    2012-12-01

    The N-terminal domain of the PriB protein from the thermophilic bacterium T. tengcongensis (TtePriB) was expressed and its crystal structure has been solved at the atomic resolution of 1.09 Å by direct methods. PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the full 220-residue protein, adopts the characteristic oligonucleotide/oligosaccharide-binding (OB) structure consisting of a five-stranded β-barrel filled with hydrophobic residues and equipped with four loops extending from the barrel. In the crystal two protomers dimerize, forming a six-stranded antiparallel β-sheet. The structure of the N-terminal OB domain of T. tengcongensis shows significant differences compared with mesophile PriBs. While in all other known structures of PriB a dimer is formed by two identical OB domains in separate chains, TtePriB contains two consecutive OB domains in one chain. However, sequence comparison of both the N-terminal and the C-terminal domains of TtePriB suggests that they have analogous structures and that the natural protein possesses a structure similar to a dimer of two N-terminal domains.

  4. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH...

  5. 26 CFR 301.7429-1 - Review of jeopardy and termination assessment and jeopardy levy procedures; information to taxpayer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Review of jeopardy and termination assessment... termination assessment and jeopardy levy procedures; information to taxpayer. Not later than 5 days after the day on which an assessment is made under section 6851(a), 6852(a), 6861(a), or 6862, or a levy is...

  6. 34 CFR 97.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Expedited review procedures for certain kinds of....110 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research...

  7. 34 CFR 222.95 - How are Indian policies and procedures reviewed to ensure compliance with the requirements in...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false How are Indian policies and procedures reviewed to ensure compliance with the requirements in section 8004(a) of the Act? 222.95 Section 222.95 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY...

  8. 22 CFR 225.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 225.110 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Expedited review procedures for certain kinds... copy of the list is available from the Office for Human Research Protections, HHS, or any successor...

  9. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  10. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  11. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  12. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  13. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE INVOLVING THE PUBLIC IN THE FORMULATION OF FOREST SERVICE DIRECTIVES § 216.6 Notice and comment procedures for proposed Manual directives... complete proposal or a summary of the proposal for review. (c) The responsible Forest Service official may...

  14. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE INVOLVING THE PUBLIC IN THE FORMULATION OF FOREST SERVICE DIRECTIVES § 216.6 Notice and comment procedures for proposed Manual directives... complete proposal or a summary of the proposal for review. (c) The responsible Forest Service official may...

  15. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE INVOLVING THE PUBLIC IN THE FORMULATION OF FOREST SERVICE DIRECTIVES § 216.6 Notice and comment procedures for proposed Manual directives... complete proposal or a summary of the proposal for review. (c) The responsible Forest Service official may...

  16. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE INVOLVING THE PUBLIC IN THE FORMULATION OF FOREST SERVICE DIRECTIVES § 216.6 Notice and comment procedures for proposed Manual directives... complete proposal or a summary of the proposal for review. (c) The responsible Forest Service official may...

  17. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... research involving no more than minimal risk, and for minor changes in approved research. 690.110 Section 690.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.110 Expedited review procedures for certain kinds of research involving no...

  18. 15 CFR 27.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... certain kinds of research involving no more than minimal risk, and for minor changes in approved research... HUMAN SUBJECTS § 27.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. (a) The Secretary, HHS, has established, and...

  19. 40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.110 Expedited review procedures for certain kinds of research involving no more than minimal...

  20. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH...

  1. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH...

  2. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH...

  3. Interventions for Echolalic Behaviour for Children with Autism: A Review of Verbal Prompts and the Cues Pause Point Procedure.

    ERIC Educational Resources Information Center

    Kavon, Nicole M.; McLaughlin, T. F.

    1995-01-01

    This paper examines behavior interventions for echolalic behavior in children with autism, including verbal prompting (focusing on the echolalic behavior itself) and the cues-pause-point procedure (which employs the child's prerequisite skills to teach correct verbal responses). A review of the literature indicated that both techniques were…

  4. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5 Supplement...

  5. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5 Supplement...

  6. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5 Supplement...

  7. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5 Supplement...

  8. 40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.110 Expedited review procedures for certain kinds of research involving no more than minimal... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26...

  9. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section 46...

  10. 40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.110 Expedited review procedures for certain kinds of research involving no more than minimal... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26...

  11. 40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.110 Expedited review procedures for certain kinds of research involving no more than minimal... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26...

  12. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section 46...

  13. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section 46...

  14. 34 CFR 97.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.110 Expedited review procedures for certain kinds of research involving no more than minimal risk... research involving no more than minimal risk, and for minor changes in approved research. 97.110 Section 97...

  15. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section 46...

  16. 75 FR 29996 - Review of MMS NEPA Policies, Practices, and Procedures for OCS Oil and Gas Exploration and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... procedures is being conducted as a result of the oil spill from the Deepwater Horizon well and drilling rig... revisions. The scope of the review is intended to be holistic, i.e. from leasing decisions to drilling and... Environmental Quality, at (202) 395- 5750. SUPPLEMENTARY INFORMATION: NEPA and Offshore Drilling Enacted in...

  17. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... research involving no more than minimal risk, and for minor changes in approved research. 690.110 Section 690.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.110 Expedited review procedures for certain kinds of research involving no...

  18. Efficacy Outcome Measures for Procedural Sedation Clinical Trials in Adults: An ACTTION Systematic Review.

    PubMed

    Williams, Mark R; McKeown, Andrew; Dexter, Franklin; Miner, James R; Sessler, Daniel I; Vargo, John; Turk, Dennis C; Dworkin, Robert H

    2016-01-01

    Successful procedural sedation represents a spectrum of patient- and clinician-related goals. The absence of a gold-standard measure of the efficacy of procedural sedation has led to a variety of outcomes being used in clinical trials, with the consequent lack of consistency among measures, making comparisons among trials and meta-analyses challenging. We evaluated which existing measures have undergone psychometric analysis in a procedural sedation setting and whether the validity of any of these measures support their use across the range of procedures for which sedation is indicated. Numerous measures were found to have been used in clinical research on procedural sedation across a wide range of procedures. However, reliability and validity have been evaluated for only a limited number of sedation scales, observer-rated pain/discomfort scales, and satisfaction measures in only a few categories of procedures. Typically, studies only examined 1 or 2 aspects of scale validity. The results are likely unique to the specific clinical settings they were tested in. Certain scales, for example, those requiring motor stimulation, are unsuitable to evaluate sedation for procedures where movement is prohibited (e.g., magnetic resonance imaging scans). Further work is required to evaluate existing measures for procedures for which they were not developed. Depending on the outcomes of these efforts, it might ultimately be necessary to consider measures of sedation efficacy to be procedure specific.

  19. Safety and Procedural Success of Left Atrial Appendage Exclusion With the Lariat Device: A Systematic Review of Published Reports and Analytic Review of the FDA MAUDE Database.

    PubMed

    Chatterjee, Saurav; Herrmann, Howard C; Wilensky, Robert L; Hirshfeld, John; McCormick, Daniel; Frankel, David S; Yeh, Robert W; Armstrong, Ehrin J; Kumbhani, Dharam J; Giri, Jay

    2015-07-01

    The Lariat device has received US Food and Drug Administration (FDA) 510(k) clearance for soft-tissue approximation and is being widely used off-label for left atrial appendage (LAA) exclusion. A comprehensive analysis of safety and effectiveness has not been reported. To perform a systematic review of published literature to assess safety and procedural success, defined as successful closure of the LAA during the index procedure, of the Lariat device. We performed a formal analytic review of the FDA MAUDE (Manufacturer and User Facility Device Experience) database to compile adverse event reports from real-world practice with the Lariat. For the systematic review, PubMed, EMBASE, CINAHL, and the Cochrane Library were searched from January 2007 through August 2014 to identify all studies reporting use of the Lariat device in 3 or more patients. The FDA MAUDE database was queried for adverse events reports related to Lariat use. Data were abstracted in duplicate by 2 physician reviewers. Events from published literature were pooled using a generic inverse variance weighting with a random effects model. Cumulative and individual adverse events were also reported using the FDA MAUDE data set. Procedural adverse events and procedural success. In the systematic review, 5 reports of Lariat device use in 309 participants were identified. Specific complications weighted for inverse of variance of individual studies were urgent need for cardiac surgery (2.3%; 7 of 309 procedures) and death (0.3%; 1 of 309 procedures). Procedural success was 90.3% (279 of 309 procedures). In the FDA MAUDE database, there were 35 unique reports of adverse events with use of the Lariat device. Among these, we identified 5 adverse event reports that noted pericardial effusion and death and an additional 23 reported urgent cardiac surgery without mention of death. This review of published reports and case reports identified risks of adverse events with off-label use of the Lariat device for LAA

  20. Antibiotic Prophylaxis for Gynecologic Procedures prior to and during the Utilization of Assisted Reproductive Technologies: A Systematic Review

    PubMed Central

    Hutchinson, Anne P.; Lekovich, Jovana P.; Hobeika, Elie; Elias, Rony T.

    2016-01-01

    The use of assisted reproductive technologies (ART) has increased steadily. There has been a corresponding increase in the number of ART-related procedures such as hysterosalpingography (HSG), saline infusion sonography (SIS), hysteroscopy, laparoscopy, oocyte retrieval, and embryo transfer (ET). While performing these procedures, the abdomen, upper vagina, and endocervix are breached, leading to the possibility of seeding pelvic structures with microorganisms. Antibiotic prophylaxis is therefore important to prevent or treat any procedure-related infections. After careful review of the published literature, it is evident that routine antibiotic prophylaxis is generally not recommended for the majority of ART-related procedures. For transcervical procedures such as HSG, SIS, hysteroscopy, ET, and chromotubation, patients at risk for pelvic infections should be screened and treated prior to the procedure. Patients with a history of pelvic inflammatory disease (PID) or dilated fallopian tubes are at high risk for postprocedural infections and should be given antibiotic prophylaxis during procedures such as HSG, SIS, or chromotubation. Antibiotic prophylaxis is recommended prior to oocyte retrieval in patients with a history of endometriosis, PID, ruptured appendicitis, or multiple prior pelvic surgeries. PMID:27047692

  1. Surveillance procedures for patients treated for endometrial cancer: a review of the literature.

    PubMed

    Sartori, Enrico; Pasinetti, Brunella; Chiudinelli, Francesca; Gadducci, Angiolo; Landoni, Fabio; Maggino, Tiziano; Piovano, Elisa; Zola, Paolo

    2010-08-01

    The aim of this review was to analyze the role of follow-up in patients treated for endometrial cancer and to provide some compelling issues that may contribute to improve daily practice while waiting for evidence-based guidelines. A literature search has been conducted in MEDLINE database using key words "endometrial neoplasms" and "follow up". Endometrial cancer represents the most common gynecologic malignancy after breast cancer. The overall recurrence rate is 13% and correlates with prognostic factors of the primary tumor. The anatomic sites of endometrial cancer relapse are mostly equivalently distributed between local (pelvic) and distant (abdominal and chest). Most endometrial cancer recurrences are symptomatic, even if vaginal vault relapses represent a particular setting of a more frequently asymptomatic disease. Most of endometrial cancer recurrences occur within 3 years since diagnosis of primary tumor. Long-term surveillance programs are mainly addressed to the early detection of recurrence, the rationale of follow-up being that an earlier diagnosis of relapse correlates with lower morbidity and mortality rates. Adjunctive objectives of routine follow-up are identification of treatment complications and detection of possible second tumors associated with endometrial cancer. No rationale (examination sensitivity/sensibility, cost-effectiveness, or patient's survival benefit) is available today for any particular follow-up protocol; follow-up procedures should probably be tailored according to different prognostic factors; only physical examination, including pelvic-rectal examination, showed some utility in detecting recurrence. In this uncertain setting, follow-up interval should be defined with the consideration of the patient's will.

  2. A systematic review on diagnostic procedures for specific language impairment: The sensitivity and specificity issues

    PubMed Central

    Shahmahmood, Toktam Maleki; Jalaie, Shohreh; Soleymani, Zahra; Haresabadi, Fatemeh; Nemati, Parvin

    2016-01-01

    Background: Identification of children with specific language impairment (SLI) has been viewed as both necessity and challenge. Investigators and clinicians use different tests and measures for this purpose. Some of these tests/measures have good psychometric properties, but it is not sufficient for diagnostic purposes. A diagnostic procedure can be used for identification a specific population with confidence only when its sensitivity and specificity are acceptable. In this study, we searched for tests/measures with predefined sensitivity and specificity for identification of preschool children with SLI from their typically developing peers. Materials and Methods: A computerized search in bibliographic databases from 2000 to August 2015 was performed with the following keywords: “specific language impairment” or SLI” and “primary language impairment” or ‘PLI’ with at least one of the followings: “diagnosis,” “identification,” “accuracy,” “sensitivity,” and “specificity.” In addition, the related citations and reference lists of the selected articles were considered. Results: The results of reviewing 23 included studies show that the index measures used in studies vary in accuracy with the sensitivity ranging from 16% to 100% and the specificity ranging from 14% to 100%. Conclusion: These varieties in sensitivity and specificity of different tests/measures confirm the necessity of attention to the diagnostic power of tests/measures before their use as diagnostic tool. Further, the results indicate there are some promising tests/measures that the available evidence supports their performances in the diagnosis of SLI in preschool-aged children, yet the place of a reference standard for the diagnosis of SLI is vacant among investigations. PMID:27904612

  3. Redislocation risk after an arthroscopic Bankart procedure in collision athletes: a systematic review.

    PubMed

    Alkaduhimi, Hassanin; van der Linde, Just A; Willigenburg, Nienke W; Paulino Pereira, Nuno Rui; van Deurzen, Derek F P; van den Bekerom, Michel P J

    2016-09-01

    The purpose of this review was to determine the redislocation risk for collision athletes after an arthroscopic Bankart repair and to compare the redislocation rate between collision athletes and noncollision athletes after an arthroscopic Bankart repair. A PubMed and Embase query was performed, screening all relevant literature of arthroscopic Bankart procedures mentioning redislocation rates in collision athletes. Studies with a follow-up <2 years or lacking information on redislocation rates in collision athletes were excluded. We used the modified Coleman Methodology Score to assess the quality of included studies. Finally, the data in all the studies were combined and analyzed. There were 1012 studies screened on title and abstract, of which 111 studies were full-text screened, and finally 20 studies were included. Four studies reported on collision athletes only, whereas 16 compared collision with noncollision athletes. Fourteen studies reported increased redislocation rates for collision athletes in comparison to noncollision athletes (absolute risk difference varying from 0.4% to 28.6%), whereas 2 studies reported decreased rates (absolute risk differences of -6% and -2.4%). A combined analysis revealed that collision athletes have an increased absolute risk of 8.09 with 95% CI from 3.61 to 12.57% for development of postoperative instability in comparison to noncollision athletes (P = .001). Collision athletes have an increased risk for redislocation in comparison to noncollision athletes after an arthroscopic Bankart repair, although there were no differences in return to sport. Copyright © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  4. Role of laser irradiation in direct pulp capping procedures: a systematic review and meta-analysis.

    PubMed

    Javed, Fawad; Kellesarian, Sergio Varela; Abduljabbar, Tariq; Gholamiazizi, Elham; Feng, Changyong; Aldosary, Khaled; Vohra, Fahim; Romanos, Georgios E

    2017-02-01

    A variety of materials are available to treat exposed dental pulp by direct pulp capping. The healing response of the pulp is crucial to form a dentin bridge and seal off the exposed pulp. Studies have used lasers to stimulate the exposed pulp to form tertiary dentin. The aim of the present systematic review and meta-analysis was to evaluate the evidence on the effects of laser irradiation as an adjunctive therapy to stimulate healing after pulp exposure. A systematic literature search was conducted up to April 2016. A structured search using the keywords "Direct pulp capping," "Lasers," "Calcium hydroxide pulp capping," and "Resin pulp capping" was performed. Initially, 34 potentially relevant articles were identified. After removal of duplicates and screening by title, abstract, and full text when necessary, nine studies were included. Studies were assessed for bias and data were synthetized using a random-effects meta-analysis model. Six studies were clinical, and three were preclinical animal trials; the follow-up period ranged from 2 weeks to 54 months. More than two thirds of the included studies showed that laser therapy used as an adjunct for direct pulp capping was more effective in maintaining pulp vitality than conventional therapy alone. Meta-analysis showed that the success rate in the laser treatment group was significantly higher than the control group (log odds ratio = 1.737; 95 % confidence interval, 1.304-2.171). Lasers treatment of exposed pulps can improve the outcome of direct pulp capping procedures; a number of confounding factors may have influenced the outcomes of the included studies.

  5. Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region.

    PubMed

    Liz, Julia; Portela, Anna; Soler, Marta; Gómez, Antonio; Ling, Hui; Michlewski, Gracjan; Calin, George A; Guil, Sònia; Esteller, Manel

    2014-07-03

    Noncoding RNAs (ncRNAs) control cellular programs by affecting protein-coding genes, but evidence increasingly points to their involvement in a network of ncRNA-ncRNA interactions. Here, we show that a long ncRNA, Uc.283+A, controls pri-miRNA processing. Regulation requires complementarity between the lower stem region of the pri-miR-195 transcript and an ultraconserved sequence in Uc.283+A, which prevents pri-miRNA cleavage by Drosha. Mutation of the site in either RNA molecule uncouples regulation in vivo and in vitro. We propose a model in which lower-stem strand invasion by Uc.283+A impairs microprocessor recognition and efficient pri-miRNA cropping. In addition to identifying a case of RNA-directed regulation of miRNA biogenesis, our study reveals regulatory networks involving different ncRNA classes of importance in cancer. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Entonox® inhalation to reduce pain in common diagnostic and therapeutic outpatient urological procedures: a review of the evidence

    PubMed Central

    Young, A; Ismail, M; Papatsoris, AG; Barua, JM; Calleary, JG; Masood, J

    2012-01-01

    INTRODUCTION Entonox® (50% nitrous oxide and 50% oxygen; BOC Healthcare, Manchester, UK) is an analgesic and anxiolytic agent that is used to successfully reduce pain and anxiety during dental, paediatric and emergency department procedures. In this article we review the application and efficacy of Entonox® in painful local anaesthesia urological procedures by performing a systematic review of the literature. METHODS A MEDLINE® search was performed using the terms ‘nitrous oxide’, ‘Entonox’, ‘prostate biopsy’, ‘flexible cystoscopy’ and ‘extracorporeal shock wave lithotripsy’. English language publications of randomised studies were identified and reviewed. RESULTS The search yielded five randomised studies that investigated the clinical efficacy of Entonox® as an analgesic for day case urological procedures. Three randomised controlled trials (RCTs) investigated Entonox® in transrectal ultrasonography guided prostate biopsy. All three reported significant reductions in pain score in the Entonox® versus control groups. One RCT reported significant reduction in pain during male flexible cystoscopy in the Entonox® group compared with the control group. One RCT, which examined the use of Entonox® during extracorporeal shock wave lithotripsy, found its use significantly decreased the pain score compared with the control group and this was comparable to intravenous pethidine. CONCLUSIONS Evidence from varied adult and paediatric procedures has shown Entonox® to be an effective, safe and patient acceptable form of analgesia. All published studies of its use in urological day case procedures have found it to significantly reduce procedural pain. There is huge potential to use this cheap, safe, effective analgesic in our current practice. PMID:22524905

  7. Remote detection of water stress conditions via a diurnal photochemical reflectance index (PRI) improves yield prediction in rainfed wheat

    NASA Astrophysics Data System (ADS)

    Magney, T. S.; Vierling, L. A.; Eitel, J.

    2014-12-01

    Employing remotely sensed techniques to quantify the existence and magnitude of midday photosynthetic downregulation using the photochemical reflectance index (PRI) may reveal new information about plant responses to abiotic stressors in space and time. However, the interpretation and application of the PRI can be confounded because of its sensitivity to several variables changing at the diurnal (e.g., irradiation, shadow fraction) and seasonal (e.g., leaf area, chlorophyll and carotene pigment concentrations, irradiation) time scales. We explored different techniques to correct the PRI for variations in canopy structure and relative chlorophyll content (ChlR) using highly temporally resolved (frequency = five minutes) in-situ radiometric measurements of PRI and the Normalized Difference Vegetation Index (NDVI) over eight soft white spring wheat (Triticum aestivum L.)field plots under varying nitrogen and soil water conditions over two seasons. Our results suggest that the influence of seasonal variation in canopy ChlR and LAI on the diurnally measured PRI (PRIdiurnal) can be minimized using simple correction techniques, therefore improving the strength of PRI as a tool to quantify abiotic stressors such as daily changes in soil volumetric water content (SVWC), and vapor pressure deficit (VPD). PRIdiurnal responded strongly to available nitrogen, and linearly tracked seasonal changes in SVWC, VPD, and stomatal conductance (gc). Utilizing the PRI as an indicator of stress, yield predictions significantly over greenness indices such as the NDVI. This study provides insight towards the future interpretation and scaling of PRI to quantify rapid changes in photosynthesis, and as an indicator of plant stress.

  8. 42 CFR 433.120 - Procedures for reduction of FFP after reapproval review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Procedures for reduction of FFP after reapproval... Claims Processing and Information Retrieval Systems § 433.120 Procedures for reduction of FFP after... conditions of reapproval in § 433.119, CMS will reduce FFP for system operations for at least four quarters...

  9. A Quantitative Review of Functional Analysis Procedures in Public School Settings

    ERIC Educational Resources Information Center

    Solnick, Mark D.; Ardoin, Scott P.

    2010-01-01

    Functional behavioral assessments can consist of indirect, descriptive and experimental procedures, such as a functional analysis. Although the research contains numerous examples demonstrating the effectiveness of functional analysis procedures, experimental conditions are often difficult to implement in classroom settings and analog conditions…

  10. A Quantitative Review of Functional Analysis Procedures in Public School Settings

    ERIC Educational Resources Information Center

    Solnick, Mark D.; Ardoin, Scott P.

    2010-01-01

    Functional behavioral assessments can consist of indirect, descriptive and experimental procedures, such as a functional analysis. Although the research contains numerous examples demonstrating the effectiveness of functional analysis procedures, experimental conditions are often difficult to implement in classroom settings and analog conditions…

  11. A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA

    PubMed Central

    Burke, James M.; Kelenis, Demetra P.; Kincaid, Rodney P.; Sullivan, Christopher S.

    2014-01-01

    Processing of primary microRNA (pri-miRNA) stem–loops by the Drosha–DGCR8 complex is the initial step in miRNA maturation and crucial for miRNA function. Nonetheless, the underlying mechanism that determines the Drosha cleavage site of pri-miRNAs has remained unclear. Two prevalent but seemingly conflicting models propose that Drosha–DGCR8 anchors to and directs cleavage a fixed distance from either the basal single-stranded (ssRNA) or the terminal loop. However, recent studies suggest that the basal ssRNA and/or the terminal loop may influence the Drosha cleavage site dependent upon the sequence/structure of individual pri-miRNAs. Here, using a panel of closely related pri-miRNA variants, we further examine the role of pri-miRNA structures on Drosha cleavage site selection in cells. Our data reveal that both the basal ssRNA and terminal loop influence the Drosha cleavage site within three pri-miRNAs, the Simian Virus 40 (SV40) pri-miRNA, pri-miR-30a, and pri-miR-16. In addition to the flanking ssRNA regions, we show that an internal loop within the SV40 pri-miRNA stem strongly influences Drosha cleavage position and efficiency. We further demonstrate that the positions of the internal loop, basal ssRNA, and the terminal loop of the SV40 pri-miRNA cooperatively coordinate Drosha cleavage position and efficiency. Based on these observations, we propose that the pri-miRNA stem, defined by internal and flanking structural elements, guides the binding position of Drosha–DGCR8, which consequently determines the cleavage site. This study provides mechanistic insight into pri-miRNA processing in cells that has numerous biological implications and will assist in refining Drosha-dependent shRNA design. PMID:24854622

  12. Potential use of the PRI and active fluorescence for the diagnosis of the physiological state of plants under ozone exposure and high atmospheric vapor pressure deficit.

    PubMed

    Merlier, Elodie; Hmimina, Gabriel; Bagard, Matthieu; Dufrêne, Eric; Soudani, Kamel

    2017-08-09

    Assessing photosynthesis rates with remote sensing is important for tracking the physiological state of plants. The photochemical reflectance index (PRI) is a good estimator of short-term light-use efficiency (LUE) at the leaf scale but its responses to environmental factors are poorly understood. In this study, we assessed changes in the responses of the PRI to ozone exposure and to an increase in atmospheric drought (separately and combined) in oak (Quercus robur) and holm oak (Quercus ilex) that were planted in climatic cells under controlled conditions. The aim was to evaluate the ability of the PRI as a relevant indicator to assess the impact of abiotic factors on photosynthesis. Leaf-scale measurements of biochemical, physiological and spectral properties, including the PRI in dim light on dark-adapted leaves (PRI0), kinetics of PRI responses to PAR variations (photosynthetically active radiation), and leaf chlorophyll fluorescence parameters were performed. The results show that PRI0 is a good proxy of the leaf chlorophyll content, and is correlated to chlorophyll fluorescence parameters on dark adapted leaves (Fo, Fm). The correction of the PRI from the leaf chlorophyll content variations (PRIc) significantly improves correlations between the PRI and NPQ (non-photochemical quenching). The variability of PARsat (estimated PAR value at PRI saturation using PRI vs. PAR relationships) depends on ozone exposure and on the increase in atmospheric vapor pressure deficit. For Quercus robur, results highlight that PARsat is linked to abiotic stress indicating that the PRI may be used as a relevant indicator of abiotic factors limiting the photosynthesis. Quercus ilex did not show significant variability in PRI0 and PARsat, which suggest that it is a more drought resistant species than Q. robur.

  13. Photochemical Reflectance Index (PRI) as a proxy of Light Use Efficiency (LUE) and transpiration in Mediterranean crop sites

    NASA Astrophysics Data System (ADS)

    LE Dantec, V.; Chebbi, W.; Boulet, G.; Merlin, O.; Lili-Chabaane, Z.; Er Raki, S.; Ceschia, E.; Khabba, S.; Fanise, P.; Zawilski, B.; Simonneaux, V.; Jarlan, L.

    2016-12-01

    The Photochemical Reflectance Index (PRI) is based on the short term reversible xanthophyll pigment changes accompanying plant stress and therefore of the associated photosynthetic activities. Strong relationships between PRI and Light Use Efficiency (LUE) were shown at leaf and canopy scales and over a wide range of species (Garbulsky et al., 2011). But very few previous works have explored the potential link with plant water status. In this study, we have first analyzed the link between PRI and LUE at canopy scale on two different crops in terms of canopy structure and crop management: olive grove (Tunisia) and wheat grown under different water regimes (irrigated or rainfed) and climate zones (France, Morocco). We have investigated the daily and seasonal dynamics of PRI; linking its variations to meteorological factors (global radiation and sun angle effects, soil water content, relative air humidity …) and plant processes. The highest correlations were mainly observed in clear skies conditions. We have found, whatever site, linear negative relationships between PRI and LUE using data acquired in midday (i.e. in solar zenithal angle condition). Linear link between PRI and sapflow measurements was also revealed. This correlation was obtained over periods characterized by a moderate soil water deficit, i.e. by when transpiration rate was mainly control by Vapor Pressure Deficit. We will then briefly presented alternative and complementary approaches to this index, to detect different level of water stress using thermal infrared emissions.

  14. [Effects of pri ming different low-dose rocurium on pharmacodynamics of mivacurium].

    PubMed

    Xin, Yan; Guo, Ying; Jiang, Yuge; Zhang, Hong

    2014-06-03

    To explore the effects of pri ming rocuronium on neuromuscular blockade produced by mivacurium. Ethical approval was granted by the medical ethics committee of our hospital with a reference number of C-2013-018-01. A total of 120 ASA physical status I and II patients undergoing selective otorhinolaryngologic surgery under general anesthesia signed the form of informed consent. And they were randomly divided by a random number table into 4 groups. After a standardized imidazole-propofol-fentanyl induction, they received a saline placebo injection (GroupI) and a pri ming dose of rocuronium 0.06 mg/kg (GroupII) , rocuronium 0.075 mg/kg (Group III) and rocuronium 0.1 mg/kg (Group IV). An intubating dose of mivacurium 0.15 mg/kg was offered 3 minutes later. Anesthesia was maintained with propofol and remifentanyl continuous infusion. Neuromuscular block was monitored with train of four (TOF) stimulation. The onset time, reappearance of T1 (DUR TOFc 1), times of T1 25% and 75% recovery, recovery index and times of TOF25%, 75% and 90% recovery were recorded. The onset time of mivacurium was significantly shorter and the times of T1 25% and 75% recovery were significantly longer in groups of II, III and IV than those in groupI. No significant difference existed in recovery index among 4 groups. The onset time of mivacurium became progressively shorter with the growing pri ming dose of rocurium among three experiment groups. And it was not statistically significant. Pri ming rocuronium decreases the onset and intubating times of mivacurium without effect on recovery index. No significant difference exists in drug effect among 3 experiment groups.

  15. 5 CFR 1201.114 - Petition and cross petition for review-content and procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... petition for review, or a response to a petition for review, whether computer generated, typed, or... review is limited to 15 pages or 3750 words, whichever is less. Computer generated and typed pleadings... of OPM. The Director of OPM may intervene in a case before the Board under the standards stated in...

  16. Cognitive versus behavioral procedures in cognitive-behavior therapy: a critical review of the evidence.

    PubMed

    Latimer, P R; Sweet, A A

    1984-03-01

    During the past decade there has been an increasing emphasis on cognition in psychology and behavior therapy. This movement has spawned several distinctive cognitive therapies. While those therapies do employ innovative cognitive treatment procedures, they often do so in the context of well-established behavioral treatment procedures which may or may not be acknowledged by the label "cognitive-behavior therapy". This paper addresses the question of whether cognitive therapy is an evolutionary or revolutionary development from behavior therapy and critically evaluates the evidence for the efficacy of procedures specific to cognitive therapy.

  17. Stimulation of pri-miR-18a Processing by hnRNP A1.

    PubMed

    Michlewski, Gracjan; Guil, Sonia; Cáceres, Javier F

    2011-01-01

    Recent evidence suggests that the canonical miRNA processing pathway can be regulated by a number of positive and negative trans-acting factors. This chapter provides an overview of hnRNP Al-mediated regulation of miR-18a biogenesis. Our laboratory has recently established that the multifunctional RNA-binding protein hnRNP Al is required for the processing of miR-18a at the nuclear step of Drosha-mediated processing. By combining structural and functional analysis of RNA, we showed that hnRNP Al regulates the processing of pri-miR-18a by binding to its terminal loop and reshaping its stem-loop structure, thus allowing for a more effective Drosha cleavage. Furthermore, we linked the event of hnRNP A1-binding to the pri-miR-18a with an unusual phylogenetic sequence conservation of its terminal loop. Bioinformatic and mutational analysis revealed that a number of pri-miRNAs have highly conserved terminal loops, which are predicted to act as landing pads for trans-acting factors influencing miRNA processing. These results underscore a previously uncharacterized role for general RNA-binding proteins as factors that facilitate the processing of specific miRNAs, revealing an additional level of complexity for the regulation of miRNA production and function.

  18. 24 CFR 15.303 - Procedure for review of demands for production of material or provision of testimony in any legal...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Response to Demands in Legal Proceedings in Which the United States Is a Party § 15.303 Procedure for review of demands for production of material or provision of testimony in any legal proceeding in which... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Procedure for review of demands...

  19. 42 CFR 137.297 - If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe, is the Self-Governance Tribe responsible for ensuring the... Process § 137.297 If the environmental review procedures of a Federal agency are adopted by a Self...

  20. 42 CFR 137.297 - If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe, is the Self-Governance Tribe responsible for ensuring the... Process § 137.297 If the environmental review procedures of a Federal agency are adopted by a Self...