Science.gov

Sample records for reviewing procedure pri

  1. PriMux

    SciTech Connect

    2010-08-31

    PriMux is used to compute sets of compatible Polymerase Chain Reaction (PCR)signatures that can be used for detecting the presence of biological species in a small sample of material. Before use, the computed signatures must be empirically tested in a wet lab.

  2. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  3. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  4. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  5. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  6. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  7. 48 CFR 242.7203 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... contractor's failure to meet one or more of the MMAS system criteria in the clause at 252.242-7004, Material... Management and Accounting System 242.7203 Review procedures. (a) Criteria for conducting reviews. Conduct...

  8. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  9. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  10. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  11. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  12. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  13. 7 CFR 28.66 - Review procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Reviews § 28.66 Review... 7 Agriculture 2 2010-01-01 2010-01-01 false Review procedure. 28.66 Section 28.66 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections,...

  14. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  15. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  16. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  17. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  18. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  19. 13 CFR 117.10 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Review procedures. 117.10 Section 117.10 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR ACTIVITIES OF SBA-EFFECTUATION OF THE AGE DISCRIMINATION ACT OF 1975, AS AMENDED §...

  20. Epilepsy and dental procedures. A review.

    PubMed

    Vorkas, Charles K; Gopinathan, Manju K; Singh, Anuradha; Devinsky, Orrin; Lin, Louis M; Rosenberg, Paul A

    2008-03-01

    This paper is a review of the dental management of patients with epilepsy. It includes discussion of the effects anti-epileptic drugs have on dental procedures and addresses complications and side effects of these drugs. A clinical case photo is presented to show gingival hyperplasia, along with four tables on which common antiepileptic medications are enumerated.

  1. Year 2000 TWRS Maintenance procedure review report

    SciTech Connect

    ADAMS, M.R.

    1999-02-24

    A concern exists that some equipment in use might contain microprocessors that are dependent upon a time date function. The majority of the software programming for microprocessors has only utilized a 2 digit identifier for the year. With the approach of the year 2000, (Y2K), there is concern that the date function will not be correctly recognized and some functions will not operate properly. TWRS maintenance procedures have been reviewed to identify equipment components that may not be Y2K compliant. Engineering judgment was utilized to eliminate procedures and equipment that is obviously not impacted by Y2K.

  2. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Peer review procedures. 34.102 Section 34.102 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.102 Peer review procedures. The OJJDP peer review process is contained in an OJJDP...

  3. MISR Browse Images: Puerto Rico Dust Experiment (PRiDE)

    Atmospheric Science Data Center

    2013-04-02

    MISR Browse Images: Puerto Rico Dust Experiment (PRiDE) These MISR Browse images provide ... overview of the region observed during the Puerto Rico Dust Experiment (PRiDE) field campaign. PRiDE was a study of the radiative, ...

  4. Linking Knowledge and Action: PRI's Community Consultant.

    ERIC Educational Resources Information Center

    Spencer, Gregory P.

    Within the Partnership for Rural Improvement (PRI), community consultants operate within three complex sets of relationships: client groups, the organizational structure of PRI, and the local operational base. Community consultants are responsible for developing and facilitating rural development and for providing assistance in community and…

  5. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  6. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  7. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  8. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  9. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  10. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  11. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  12. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  13. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  14. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  15. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  16. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  17. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Procedures for hearing and review. 10.24 Section 10.24... RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures for... requirements set forth in § 10.22, the Director, Office of Administration, shall forthwith appoint a...

  18. 23 CFR 230.409 - Contract compliance review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PROGRAMS Construction Contract Equal Opportunity Compliance Procedures § 230.409 Contract compliance review... proper completion of procedural requirements and to ascertain the effectiveness of program implementation...) No compliance review shall be conducted that is based on a home office work force of less than...

  19. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  20. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  1. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  2. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  3. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  4. 20 CFR 410.704 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-BLACK LUNG BENEFITS (1969- ) Rules for the Review of Denied and Pending Claims Under the Black Lung... establishes entitlement to benefits under the BLBRA of 1977. Evidence on file is information in the black...

  5. 20 CFR 410.704 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-BLACK LUNG BENEFITS (1969- ) Rules for the Review of Denied and Pending Claims Under the Black Lung... establishes entitlement to benefits under the BLBRA of 1977. Evidence on file is information in the black...

  6. 19 CFR 351.221 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) questionnaires requesting factual information for the review; (3) Conduct, if appropriate, a verification under... the case may be); and (ii) Normally will send questionnaires no later than 30 days after the date of... that expedited action is warranted; and (iii) May refrain from issuing questionnaires under...

  7. Procedural and Conceptual Knowledge: Adults Reviewing Fractions

    ERIC Educational Resources Information Center

    Baker, William J.; Czarnocha, Bronislaw; Dias, Olen; Doyle, Kathleen; Kennis, James R.

    2012-01-01

    In the United States a majority of the students who enroll in community colleges require a review of secondary math before they are eligible for college level mathematics. In the pre-algebra course, that has a high drop-out rate, the most difficult topic for students is fractions. In order to better understand the fraction concept, Kieren…

  8. Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins.

    PubMed

    Coelho, Miguel B; Ascher, David B; Gooding, Clare; Lang, Emma; Maude, Hannah; Turner, David; Llorian, Miriam; Pires, Douglas E V; Attig, Jan; Smith, Christopher W J

    2016-08-15

    Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands.

  9. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... review procedures. 1552.237-70 Section 1552.237-70 Federal Acquisition Regulations System ENVIRONMENTAL... publish, in a scientific journal, material resulting directly or indirectly from work performed under this... in a journal article which has not been subjected to EPA review: “Although the research described...

  10. 29 CFR 801.69 - Procedures for initiating review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Vacation of Decision and Order of Administrative Law Judge § 801.69 Procedures for initiating review. (a) Within twenty (20) days after the date of the decision of the Administrative Law Judge, the respondent... which review is sought. A copy of the Decision and Order of the Administrative Law Judge shall...

  11. 76 FR 4933 - Environmental Review Procedures for Entities Assuming HUD Environmental Review Responsibilities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Responsibilities; Notice of Proposed Information Collection: Comment Request AGENCY: Office of the Assistant...: Environmental Review Procedures for Entities Assuming HUD Environmental Responsibilities. OMB Control...

  12. A review of the EXIT (Ex utero Intrapartum Treatment) procedure.

    PubMed

    Abraham, R J; Sau, A; Maxwell, D

    2010-01-01

    The EXIT (Ex utero Intrapartum Treatment) procedure is done in cases where difficulty is anticipated in neonatal airway establishment at delivery and is done at the time of caesarean section. The partially delivered fetus is maintained on placental circulation while airway is established and this is carried out by a multidisciplinary team. In this paper, we review the indications, the maternal and fetal considerations of the procedure and the results and outcomes. The review highlights the fact that the benefits far outweigh the risks and that the risk of postpartum haemorrhage is more theoretical than real. As technology improves and more anomalies are diagnosed during the antenatal period, the EXIT procedure can be performed with good results after carefully considering the ethical issues. We have performed a MEDLINE search by using the keywords EXIT, CHAOS, fetal surgery, fetal neck masses and ex utero intrapartum treatment. As there are not many large studies, we have also reviewed smaller case series and case reports.

  13. Standard Review Plan Update and Development Program. Implementing Procedures Document

    SciTech Connect

    Not Available

    1992-05-01

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures.

  14. Standard Review Plan Maintenance Program implementing procedures document

    SciTech Connect

    1996-11-01

    The implementing Procedures Document (IPD) was developed by the Inspection Program Projects Branch, Office of Nuclear Reactor Regulation, with assistance from Pacific Northwest National Laboratory, for the Standard Review Plan Maintenance Program (SRP-MP). The SRP-MP was established to maintain the Standard Review Plan (SRP) on an on-going basis. The IPD provides guidance, including an overall approach and procedures, for SRP-MP tasks. The objective of the IPD is to ensure that modifications to SRP need to reflect current NRC requirements and guidance are identified and that a consistent methodology is used to develop and revise SRP sections.

  15. 49 CFR 802.14 - Review procedure and judicial review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... TRANSPORTATION SAFETY BOARD RULES IMPLEMENTING THE PRIVACY ACT OF 1974 Review of Initial Adverse Determination..., DC 20594, and shall contain a statement on the envelope and in the appeal: “Appeal from Privacy Act... envelope, “Privacy Act Statement of Disagreement.” (2) The Director, Bureau of Administration, or...

  16. 41 CFR 109-28.5004 - Justification and review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROCUREMENT 28-STORAGE AND DISTRIBUTION 28.50-Management of Equipment Held for Future Projects § 109-28.5004... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Justification and review procedures. 109-28.5004 Section 109-28.5004 Public Contracts and Property Management Federal...

  17. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... review procedures. 1552.237-70 Section 1552.237-70 Federal Acquisition Regulations System ENVIRONMENTAL... Contracting Officer in writing. (c) The Contractor may publish, in a scientific journal, material resulting... for publication. (2) The Contractor shall include the following statement in a journal article...

  18. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... review procedures. 1552.237-70 Section 1552.237-70 Federal Acquisition Regulations System ENVIRONMENTAL... Contracting Officer in writing. (c) The Contractor may publish, in a scientific journal, material resulting... for publication. (2) The Contractor shall include the following statement in a journal article...

  19. 29 CFR 500.264 - Procedures for initiating review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Order of Administrative Law Judge § 500.264 Procedures for initiating review. (a) Within twenty (20) days after the date of the decision of the Administrative Law Judge, the respondent, the Administrator.... A copy of the Decision and Order of the Administrative Law Judge shall be attached to the...

  20. 42 CFR 431.980 - Eligibility review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... procedures as of the review month and identify payments made on behalf of such beneficiary or family for... of such beneficiary or family in the first 30 days of eligibility. (B) If the last action occurred... payments made on behalf of the beneficiary or family for services received in the sample month. (iii)...

  1. Hypnosis before diagnostic or therapeutic medical procedures: a systematic review.

    PubMed

    Cheseaux, Nicole; de Saint Lager, Alix Juillet; Walder, Bernhard

    2014-01-01

    The aim of this systematic review was to estimate the efficiency of hypnosis prior to medical procedures. Different databases were analyzed to identify randomized controlled trials (RCTs) comparing hypnosis to control interventions. All RCTs had to report pain or anxiety. Eighteen RCTs with a total of 968 patients were included; study size was from 20 to 200 patients (14 RCTs ≤ 60 patients). Fourteen RCTs included 830 adults and 4 RCTs included 138 children. Twelve of 18 RCTs had major quality limitations related to unclear allocation concealments, provider's experience in hypnosis, patient's adherence to hypnotic procedures, and intention-to-treat design. This systematic review observed major methodological limitations in RCTs on hypnosis prior to medical procedures.

  2. Review of the IEEE Standard for Computerized Operating Procedure Systems

    SciTech Connect

    O'Hara, J.; Higgins, J.

    2010-02-26

    Increasingly nuclear power plant procedures, such as emergency operating procedures, are being presented in computer form with functionality to support operator use and management of the procedures. The U.S. Nuclear Regulatory Commission (NRC) currently has guidance for the review of computer-based procedures (CBPs); however, there remain CBP functions and human performance issues for which up-to-date guidance is lacking. The Institute of Electrical and Electronics Engineers (IEEE) has initiated a standard development effort to address the human factors engineering (HFE) aspects of CBP systems. When completed, it may provide guidance to supplement the NRC staff's review criteria. The purpose of our study was to evaluate the suitability of the IEEE Standard for use in the NRC's HFE safety reviews of CBP systems and to ensure that the guidance meets the NRC's standard for scientific and engineering rigor used in its own guidance development efforts. We established the following criteria with which to evaluate the Standard: (1) it should meet an existing need of NRC reviewers, (2) it should be based in sound HFE principles, (3) it should be thoroughly peer-reviewed, and (4) it should address CBP-related human performance issues identified in the literature. This report describes the methodology we used to evaluate each criterion. Our evaluation concluded that the Standard generally does meet these criteria, however several areas were identified for which additional clarifications are needed. Thus consideration of the Standard's use by the NRC is supported. The standard evaluation methodology developed in this study can be generally applied to the review of other HFE standards being considered for possible use or endorsement by the NRC.

  3. Neurosurgical procedures in patients with liver cirrhosis: A review

    PubMed Central

    Chen, Ching-Chang; Huang, Yin-Cheng; Yeh, Chun-Nan

    2015-01-01

    Liver cirrhosis, a devastating liver fibrosis caused by hepatitis/inflammation or tumors, is a major comorbid factor in known surgery fields, such as cardiovascular and abdominal surgeries. It is important to review possible comorbid results in neurosurgical procedures in cirrhotic patients. In the reviewed literature, Child-Pugh and model for end-stage liver disease scores are commonly used in the assessment of surgical risks for cirrhotic patients undergoing abdominal, cardiovascular or neurosurgical procedures. The major categories of neurosurgery are traumatic brain injury (TBI), spontaneous intracranial hemorrhage (SICH), brain tumors, and spinal instrumentation procedures. TBI was reported with surgical mortality as high as 34.5% and a complication rate of 87.2%. For SICH, mortality ranged from 22.7% to 47.0%, while complications were reported to be 43.2%. Less is discussed in brain tumor patients; still the postoperative hemorrhage rate approached 26.7%. In spinal fusion instrumentation procedures, the complication rate was as high as 41.0%. Preoperative assessment and correction could possibly decrease complications such as hemorrhage, wound infection and other cirrhosis-related complications (renal, pulmonary, ascites and encephalopathy). In this study, we reviewed the neurosurgical-related literature with regard to liver cirrhosis as a prognostic factor influencing neurosurgical outcomes. PMID:26413225

  4. [Ultrasound guided radial artery cannulation: procedure description and literature review].

    PubMed

    Carmona Monge, F J; Martínez Lareo, M; Núñez Reiz, A

    2011-01-01

    Arterial catheterization is the second most common invasive procedure performed in critical care units. These devices are essential in certain types of patients (the hemodinamically unstable or those who require regular evaluation of the gasometric values). Complications related to arterial cannulation are relatively scarce. However, there are no reliable indicators to predict the occurrence of radial artery occlusions or ischemic lesions in the hand after a radial cannulation procedure has been performed. Ultrasound-guided catheter insertion has been used for years to guide central venous cannulation in critical care, but its use has been more limited for arterial catheterization. This paper aims to describe the technique of ultrasound-guided radial artery catheterization and reviews the most important research papers that have evaluated the safety and efficacy of this procedure in the adult population.

  5. Observation procedures characterizing occupational physical activities: critical review.

    PubMed

    Denis, D; Lortie, M; Rossignol, M

    2000-01-01

    The first objective of this paper is to compare the observation procedures proposed to characterize physical work. The second objective is to examine the following 3 methodological issues: reliability, observer training, and internal validity. Seventy-two papers were reviewed, 38 of which proposed a new or modified observation grid. The observation variables identified were broken down into 7 categories as follows: posture, exertion, load handled, work environment, use of feet, use of hands, and activities or tasks performed. The review revealed the variability of existing procedures. The examination of methodological issues showed that observation data can be reliable and can present an adequate internal validity. However, little information about the conditions necessary to achieve good reliability was available.

  6. Effectiveness of granite cleaning procedures in cultural heritage: A review.

    PubMed

    Pozo-Antonio, J S; Rivas, T; López, A J; Fiorucci, M P; Ramil, A

    2016-11-15

    Most of the Cultural Heritage built in NW Iberian Peninsula is made of granite which exposition to the environment leads to the formation of deposits and coatings, mainly two types: biological colonization and sulphated black crusts. Nowadays, another form of alteration derives from graffiti paints when these are applied as an act of vandalism. A deep revision needs to be addressed considering the severity of these deterioration forms on granite and the different cleaning effectiveness achieved by cleaning procedures used to remove them. The scientific literature about these topics on granite is scarcer than on sedimentary carbonate stones and marbles, but the importance of the granite in NW Iberian Peninsula Cultural Heritage claims this review centred on biological colonization, sulphated black crusts and graffiti on granite and their effectiveness of the common cleaning procedures. Furthermore, this paper carried out a review of the knowledge about those three alteration forms on granite, as well as bringing together all the major studies in the field of the granite cleaning with traditional procedures (chemical and mechanical) and with the recent developed technique based on the laser ablation. Findings concerning the effectiveness evaluation of these cleaning procedures, considering the coating extraction ability and the damage induced on the granite surface, are described. Finally, some futures research lines are pointed out.

  7. Review of advanced catheter technologies in radiation oncology brachytherapy procedures

    PubMed Central

    Zhou, Jun; Zamdborg, Leonid; Sebastian, Evelyn

    2015-01-01

    The development of new catheter and applicator technologies in recent years has significantly improved treatment accuracy, efficiency, and outcomes in brachytherapy. In this paper, we review these advances, focusing on the performance of catheter imaging and reconstruction techniques in brachytherapy procedures using magnetic resonance images and electromagnetic tracking. The accuracy of catheter reconstruction, imaging artifacts, and other notable properties of plastic and titanium applicators in gynecologic treatments are reviewed. The accuracy, noise performance, and limitations of electromagnetic tracking for catheter reconstruction are discussed. Several newly developed applicators for accelerated partial breast irradiation and gynecologic treatments are also reviewed. New hypofractionated high dose rate treatment schemes in prostate cancer and accelerated partial breast irradiation are presented. PMID:26203277

  8. Review of advanced catheter technologies in radiation oncology brachytherapy procedures.

    PubMed

    Zhou, Jun; Zamdborg, Leonid; Sebastian, Evelyn

    2015-01-01

    The development of new catheter and applicator technologies in recent years has significantly improved treatment accuracy, efficiency, and outcomes in brachytherapy. In this paper, we review these advances, focusing on the performance of catheter imaging and reconstruction techniques in brachytherapy procedures using magnetic resonance images and electromagnetic tracking. The accuracy of catheter reconstruction, imaging artifacts, and other notable properties of plastic and titanium applicators in gynecologic treatments are reviewed. The accuracy, noise performance, and limitations of electromagnetic tracking for catheter reconstruction are discussed. Several newly developed applicators for accelerated partial breast irradiation and gynecologic treatments are also reviewed. New hypofractionated high dose rate treatment schemes in prostate cancer and accelerated partial breast irradiation are presented.

  9. Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells

    PubMed Central

    Milczarek, Magdalena; Chodyński, Michał; Filip-Psurska, Beata; Martowicz, Agnieszka; Krupa, Małgorzata; Krajewski, Krzysztof; Kutner, Andrzej; Wietrzyk, Joanna

    2013-01-01

    Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) and tacalcitol (PRI-2191) were used as the reference compounds. Among a series of tested analogs the diastereomeric analog PRI-2202 showed the strongest antiproliferative activity on the human breast cancer cell line MCF-7, whereas the geometric analog PRI-2205 was the weakest. Both analogs were less potent in antiproliferative activity against HL-60 cells compared to the reference compounds. The ability to potentiate antiproliferative effect of cisplatin or doxorubicin against HL-60 cells or that of tamoxifen against the MCF-7 cell line was observed at higher doses of PRI-2202 or PRI-2205 than those of the reference compounds. The proapoptotic activity of tamoxifen, expressed as the diminished mitochondrial membrane potential, as well as the increased phosphatidylserine expression, was partially attenuated by calcitriol, PRI-2191, PRI-2201 and PRI-2205. The treatment of the MCF-7 cells with tamoxifen alone resulted in an increase in VDR expression. Moreover, a further increase in VDR expression was observed when the analogs PRI-2201 or PRI-2205, but not PRI-2191, were used in combination with tamoxifen. This observation could partially explain the potentiation of the antiproliferative effect of tamoxifen by vitamin D analogs. PMID:24202449

  10. Structural mechanisms of PriA-mediated DNA replication restart.

    PubMed

    Bhattacharyya, Basudeb; George, Nicholas P; Thurmes, Tiffany M; Zhou, Ruobo; Jani, Niketa; Wessel, Sarah R; Sandler, Steven J; Ha, Taekjip; Keck, James L

    2014-01-28

    Collisions between cellular DNA replication machinery (replisomes) and damaged DNA or immovable protein complexes can dissociate replisomes before the completion of replication. This potentially lethal problem is resolved by cellular "replication restart" reactions that recognize the structures of prematurely abandoned replication forks and mediate replisomal reloading. In bacteria, this essential activity is orchestrated by the PriA DNA helicase, which identifies replication forks via structure-specific DNA binding and interactions with fork-associated ssDNA-binding proteins (SSBs). However, the mechanisms by which PriA binds replication fork DNA and coordinates subsequent replication restart reactions have remained unclear due to the dearth of high-resolution structural information available for the protein. Here, we describe the crystal structures of full-length PriA and PriA bound to SSB. The structures reveal a modular arrangement for PriA in which several DNA-binding domains surround its helicase core in a manner that appears to be poised for binding to branched replication fork DNA structures while simultaneously allowing complex formation with SSB. PriA interaction with SSB is shown to modulate SSB/DNA complexes in a manner that exposes a potential replication initiation site. From these observations, a model emerges to explain how PriA links recognition of diverse replication forks to replication restart.

  11. A review of human drug self-administration procedures

    PubMed Central

    Jones, Jermaine D.; Comer, Sandra D.

    2014-01-01

    Drug self-administration procedures in laboratory settings allow us to closely model drug-taking behavior in real-world settings. This review provides an overview of many of the common self-administration methods used in human laboratory research. Typically, self-administration studies provide a quantifiable measure of the reinforcing effect of a drug, which is believed to be predictive of its potential for abuse. Several adaptations of the self-administration paradigm exist, the simplest of which allows participants free access to the drug under investigation. Free-access procedures allow investigators to observe patterns of drug self-administration and drug effects in a controlled setting. Allowing participants to choose between two simultaneously available reinforcers (choice procedures) is another well-established method of assessing the reinforcing effects of a drug. Offering a choice between two reinforcers (e.g. two different doses of the same drug, two different drugs, or drug and nondrug reinforcers) provides researchers with a point of comparison (e.g. between a drug of known abuse potential and a novel drug). When combined with other endpoints, such as subjective effects ratings, physiological responses, and cognitive performance, human self-administration paradigms have contributed significantly to our understanding of the factors that contribute to, maintain, and alter drug-taking behavior including: craving, positive subjective effects, toxicity, drug interactions and abstinence. This area of research has also begun to incorporate other techniques such as imaging and genetics to further understand the multifaceted nature of substance abuse. The present paper summarizes the different self-administration techniques that are commonly used today and the application of other procedures that may complement interpretation of the drug PMID:23839027

  12. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  13. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  14. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  15. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures... pesticide's registration review docket the Agency's proposed decision and the bases for the decision. There... standard for registration and describe the basis for such proposed findings. (2) Identify proposed...

  16. Explaining the variability of Photochemical Reflectance Index (PRI): deconvolution of variability related to Light Use Efficiency and Canopy attributes.

    NASA Astrophysics Data System (ADS)

    Merlier, Elodie; Hmimina, Gabriel; Dufrêne, Eric; Soudani, Kamel

    2014-05-01

    . 1992. A narrow-waveband spectral index that tracks diurnal changes in photosynthetic efficiency. Remote Sensing of Environment 41, 35-44. Garbulsky MF, Peñuelas J, Gamon J, Inoue Y, Filella I. 2011. The photochemical reflectance index (PRI) and the remote sensing of leaf, canopy and ecosystem radiation use efficiencies: A review and meta-analysis. Remote Sensing of Environment 115, 281-297. Hilker T, Coops NC, Hall FG, Black TA, Wulder MA, Nesic Z, Krishnan P. 2008. Separating physiologically and directionally induced changes in PRI using BRDF models. Remote Sensing of Environment 112, 2777-2788. Hmimina G, Dufrêne E, Soudani K. 2014. Relationship between PRI and leaf ecophysiological and biochemical parameters under two different water statuses: toward a rapid and efficient correction method using real-time measurements. Plant, Cell & Environment 37, 2, 473-487. Nakaji T, Oguma H, Fujinuma Y. 2006. Seasonal changes in the relationship between photochemical reflectance index and photosynthetic light use efficiency of Japanese larch needles. International Journal of Remote Sensing 27, 493-509. Rahimzadeh-Bajgiran P, Munehiro M, Omasa K. 2012. Relationships between the photochemical reflectance index (PRI) and chlorophyll fluorescence parameters and plant pigment indices at different leaf growth stages. Photosynthesis Research 113, 261-271.

  17. 5 CFR 1201.117 - Board decisions; procedures for review or reopening.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Board decisions; procedures for review or reopening. 1201.117 Section 1201.117 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES AND PROCEDURES Petitions for Review of Initial Decisions § 1201.117...

  18. 20 CFR 404.976 - Procedures before Appeals Council on review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Procedures before Appeals Council on review. 404.976 Section 404.976 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS... Determinations and Decisions Appeals Council Review § 404.976 Procedures before Appeals Council on review....

  19. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  20. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  1. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  2. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  3. 29 CFR 502.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER... of Administrative Law Judge's Decision § 502.42 Procedures for initiating and undertaking review....

  4. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track...

  5. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track...

  6. DOE EERE Standard Operating Procedure Peer Review Best Practice and Procedures

    SciTech Connect

    2009-01-18

    Objective review and advice from peers - peer review - provides managers, staff, and researchers with a powerful and effective tool for enhancing the management, relevance, effectiveness, and productivity of all of the EERE research, development

  7. Ethical review: Standardizing procedures and local shaping of ethical review practices.

    PubMed

    Jaspers, Patricia; Houtepen, Rob; Horstman, Klasien

    2013-12-01

    Since ethical review practice has developed in relation to specific regulatory regimes and local contexts, it cannot be understood without paying attention to the institutional context of ethical review practices. We believe the tendency towards strong central governance and standardization in ethical review implies a lack of understanding of how specific local institutional contexts actually affect ethical review practices. Our question is: "How do local institutional contexts relate to the way REC's shape their formal mandate, and what are the implications for research governance?" To get in-depth insights in how REC's shape their formal mandates in every-day practice, we did a qualitative ethnographic-sociological study of three Dutch REC's in different contexts: an academic context, a care context and a commercial context. In analyzing these three REC's we paid attention to the procedures operative in REC practices, the cultures and everyday experiences of REC members, the scientific, social and financial resources that are available to REC's, and the evaluative perspective REC's employ. We conclude that specific local, institutional contexts offer valuable resources for ethical review. To track this, insight into the institutional configuration as a whole is necessary. Variations in the ways REC's shape their formal mandate should not be regarded problematic, but rather as fruitful opportunities for public learning.

  8. Constant and Progressive Time Delay Procedures for Teaching Children with Autism: A Literature Review

    ERIC Educational Resources Information Center

    Walker, Gabriela

    2008-01-01

    A review of 22 empirical studies examining the use of constant (CTD) and progressive (PTD) time delay procedures employed with children with autism frames an indirect analysis of the demographic, procedural, methodological, and outcome parameters of existing research. None of the previous manuscripts compared the two response prompting procedures.…

  9. 49 CFR 194.121 - Response plan review and update procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Response plan review and update procedures. 194... SAFETY RESPONSE PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.121 Response plan review and update procedures. (a) Each operator shall update its response plan to address new or different operating...

  10. 78 FR 49280 - 60-Day Notice of Proposed Information Collection: Environmental Review Procedures for Entities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... environmental laws, executive orders, and authorities, and Part 58 procedure. When the environmental review... certify their compliance with all applicable environmental laws and authorities. HUD (or the State for... URBAN DEVELOPMENT 60-Day Notice of Proposed Information Collection: Environmental Review Procedures...

  11. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Accreditation Body § 8.28 Expedited procedures for review of immediate suspension. (a) Applicability. When...

  12. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Accreditation Body § 8.28 Expedited procedures for review of immediate suspension. (a) Applicability. When...

  13. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  14. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  15. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  16. Finding the SurPriSe: A Case Study of a Faculty Learning Community

    ERIC Educational Resources Information Center

    Michel, Roberta M.

    2014-01-01

    This article details a faculty learning community (FLC) that started in 2009 on the campus of a Midwestern University and has evolved into an interdisciplinary research, teaching and social community of practice and learning called SurPriSe. SurPriSe is an acronym that reflects the interest area of the FLC; Sur for surveillance, Pri for privacy,…

  17. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., “Application for Review of Discharge or Separation from the Armed Forces of the United States,” with such other..., The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within 15... (including decisions maintained by the Armed Forces Discharge Review Board/Corrective Board Reading...

  18. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., “Application for Review of Discharge or Separation from the Armed Forces of the United States,” with such other..., The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within 15... (including decisions maintained by the Armed Forces Discharge Review Board/Corrective Board Reading...

  19. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., “Application for Review of Discharge or Separation from the Armed Forces of the United States,” with such other..., The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within 15... (including decisions maintained by the Armed Forces Discharge Review Board/Corrective Board Reading...

  20. HYPNOSIS FOR ACUTE PROCEDURAL PAIN: A Critical Review

    PubMed Central

    Kendrick, Cassie; Sliwinski, Jim; Yu, Yimin; Johnson, Aimee; Fisher, William; Kekecs, Zoltán; Elkins, Gary

    2015-01-01

    Clinical evidence for the effectiveness of hypnosis in the treatment of acute, procedural pain was critically evaluated based on reports from randomized controlled clinical trials (RCTs). Results from the 29 RCTs meeting inclusion criteria suggest that hypnosis decreases pain compared to standard care and attention control groups and that it is at least as effective as comparable adjunct psychological or behavioral therapies. In addition, applying hypnosis in multiple sessions prior to the day of the procedure produced the highest percentage of significant results. Hypnosis was most effective in minor surgical procedures. However, interpretations are limited by considerable risk of bias. Further studies using minimally effective control conditions and systematic control of intervention dose and timing are required to strengthen conclusions. PMID:26599994

  1. Procedural justice and layoff survivors' commitment: a quantitative review.

    PubMed

    Grubb, W Lee

    2006-10-01

    Layoffs are common in today's organizations. Most studies that have examined the correlation between procedural justice and the organizational commitment of layoff survivors have yielded positive correlations, but the magnitude of the correlations varies widely. This study is the first to estimate the population correlation and to identify the primary sources that cause variation in the correlation across studies. The results indicated that justice and commitment correlations can always be expected to be positive. Based on a total sample size of 9080 individuals, the estimated mean population correlation was .34. Variation was primarily explained by attributes of the justice measure where multiple items scales and scales composed of both interactional and procedural justice items yielded higher correlations than single item measures. Therefore, it is important that employers recognize the substantial assuaging affect that procedural and interactional justice can have on survivors' organizational commitment.

  2. Hypnosis for Acute Procedural Pain: A Critical Review.

    PubMed

    Kendrick, Cassie; Sliwinski, Jim; Yu, Yimin; Johnson, Aimee; Fisher, William; Kekecs, Zoltán; Elkins, Gary

    2016-01-01

    Clinical evidence for the effectiveness of hypnosis in the treatment of acute procedural pain was critically evaluated based on reports from randomized controlled clinical trials (RCTs). Results from the 29 RCTs meeting inclusion criteria suggest that hypnosis decreases pain compared to standard care and attention control groups and that it is at least as effective as comparable adjunct psychological or behavioral therapies. In addition, applying hypnosis in multiple sessions prior to the day of the procedure produced the highest percentage of significant results. Hypnosis was most effective in minor surgical procedures. However, interpretations are limited by considerable risk of bias. Further studies using minimally effective control conditions and systematic control of intervention dose and timing are required to strengthen conclusions.

  3. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... Administration, or by writing to: DA Military Review Boards Agency, Attention: SFBA (Reading Room), Room 1E520, The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within...

  4. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... Administration, or by writing to: DA Military Review Boards Agency, Attention: SFBA (Reading Room), Room 1E520, The Pentagon, Washington, DC 20310. (2) Timing. A motion or request for review must be made within...

  5. Transcatheter Renal Interventions: A Review of Established and Emerging Procedures

    PubMed Central

    Minocha, Jeet; Parvinian, Ahmad; Bui, James T; Knuttinen, Martha Grace; Ray, Charles E; Gaba, Ron C

    2015-01-01

    Catheter-based interventions play an important role in the multidisciplinary management of renal pathology. The array of procedures available to interventional radiologists (IRs) includes established techniques such as angioplasty, stenting, embolization, thrombolysis, and thrombectomy for treatment of renovascular disease, as well as embolization of renal neoplasms and emerging therapies such as transcatheter renal artery sympathectomy for treatment of resistant hypertension. Here, we present an overview of these minimally invasive therapies, with an emphasis on interventional technique and clinical outcomes of the procedure. PMID:25806140

  6. Development of electrical test procedures for qualification of spacecraft against EID. Volume 2: Review and specification of test procedures

    NASA Technical Reports Server (NTRS)

    Wilkenfeld, J. M.; Harlacher, B. L.; Mathews, D.

    1982-01-01

    A combined experimental and analytical program to develop system electrical test procedures for the qualification of spacecraft against damage produced by space-electron-induced discharges (EID) occurring on spacecraft dielectric outer surfaces is described. A review and critical evaluation of possible approaches to qualify spacecraft against space electron-induced discharges (EID) is presented. A variety of possible schemes to simulate EID electromagnetic effects produced in spacecraft was studied. These techniques form the principal element of a provisional, recommended set of test procedures for the EID qualification spacecraft. Significant gaps in our knowledge about EID which impact the final specification of an electrical test to qualify spacecraft against EID are also identified.

  7. [Review As You Go: Oklahoma City Public Schools' Plan Using Saxon's Procedures.

    ERIC Educational Resources Information Center

    Hartzler, Stan

    This document consists of three related items. The first brief paper describes the components of a cumulative daily review program and its origins, rationale, and outcomes. The review-as-you-go (RAYG) format entails planning cumulative examinations and providing review problems each day. The procedure once was routinely used; today it is…

  8. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Assess the strengths and areas of the State's child and family services programs that require further..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES GENERAL § 1355.33 Procedures for...

  9. Applications of Self-Control Procedures by Children: A Review.

    ERIC Educational Resources Information Center

    O'Leary, Susan G.; Dubey, Dennis R.

    1979-01-01

    Particular emphasis is on self-instruction, self-determined criteria, self-assessment, and self-reinforcement. Self-punishment, comprehensive programs, and innovative self-control procedures (including distraction and restatement of contingencies) are also evaluated. (Author/DLS)

  10. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES GENERAL § 1355.33 Procedures for...

  11. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES GENERAL § 1355.33 Procedures for...

  12. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES GENERAL § 1355.33 Procedures for...

  13. NAFTA Revised Procedures for Joint Review of Microbials and Semiochemicals

    EPA Pesticide Factsheets

    The Canadian Pest Management Regulatory Agency and EPA have established a process for the joint review of pest control products in which the new active ingredient is a microbial or an arthropod semiochemical (including pheromones).

  14. The Veterinary Forensic Necropsy: A Review of Procedures and Protocols.

    PubMed

    Brownlie, H W Brooks; Munro, R

    2016-09-01

    Investigation of animal-related crime, and therefore submission of forensic cases to veterinary pathology facilities, is increasing, yet many veterinary pathologists are unfamiliar and often uncomfortable with involvement in the forensic necropsy. This article discusses various aspects of the forensic necropsy without specific attention to any particular species group or crime. General advice is given on procedures, documentation, and recording of the examination, and the article indicates how these features may differ from those used in investigation of natural disease. It also discusses evidence management, including recordkeeping, identification of evidence, labeling of photographs, and use of standard operating procedures and protocols. Various written and visual methods for documentation of the forensic necropsy are covered, and adjunctive topics such as sample collection, assessment, and description of wounds and taphonomy are included. Cause, mechanism, and manner of death are defined, and guidance to the use of these terms is given. The aim of this article is to offer guidance on procedural aspects of the forensic necropsy that will help those developing their forensic services, contribute to standardization of the provision of forensic veterinary pathology, and build the confidence of the "uncomfortable" forensic veterinary pathologist.

  15. 29 CFR 2570.12 - Procedures for review by the Secretary.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Civil Sanctions Under ERISA Section 502(i) § 2570.12 Procedures for review by the Secretary. (a) Upon...) taken. Such decision by the Secretary shall be final agency action within the meaning of 5 U.S.C. 704....

  16. 29 CFR 2570.71 - Procedures for review by the Secretary.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Civil Penalties Under ERISA Section 502(c)(2) § 2570.71 Procedures for review by the Secretary. (a) Upon...(s) taken. Such decision by the Secretary shall be final agency action within the meaning of 5...

  17. 29 CFR 2570.101 - Procedures for review by the Secretary.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Civil Penalties Under ERISA Section 502(c)(5) § 2570.101 Procedures for review by the Secretary. (a... the action(s) taken. Such decision by the Secretary shall be final agency action within the meaning...

  18. 29 CFR 503.51 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATIONS ENFORCEMENT OF OBLIGATIONS FOR TEMPORARY NONIMMIGRANT NON-AGRICULTURAL WORKERS ADMITTED UNDER... Administrative Law Judge's Decision § 503.51 Procedures for initiating and undertaking review. (a) A...

  19. 29 CFR 503.51 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REGULATIONS ENFORCEMENT OF OBLIGATIONS FOR TEMPORARY NONIMMIGRANT NON-AGRICULTURAL WORKERS ADMITTED UNDER... Administrative Law Judge's Decision § 503.51 Procedures for initiating and undertaking review. (a) A...

  20. 29 CFR 503.51 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REGULATIONS ENFORCEMENT OF OBLIGATIONS FOR TEMPORARY NONIMMIGRANT NON-AGRICULTURAL WORKERS ADMITTED UNDER... Administrative Law Judge's Decision § 503.51 Procedures for initiating and undertaking review. (a) A...

  1. 78 FR 64234 - 30-Day Notice of Proposed Information Collection: Environmental Review Procedures for Entities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... (NEPA), the regulations of the Council on Environmental Quality, related federal environmental laws... compliance with all applicable environmental laws and authorities. HUD (or the State for certain State... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Environmental Review Procedures...

  2. 75 FR 10807 - Subcommittee on Procedures Reviews (SPR), Advisory Board on Radiation and Worker Health (ABRWH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... procedure for reviewing OCAS Program Evaluation Reports; and discussion of the following Oak Ridge... Neutron Dose at the Oak Ridge Y-12 Facility''), OTIB-0054 (``Fission and Activation Product Assignment...

  3. Review of Monitoring Procedures with Mildly Handicapped Students.

    ERIC Educational Resources Information Center

    Fuchs, Lynn S.

    This paper presents a comprehensive review of special and remedial education practice in formative evaluation of goal attainment among mildly handicapped students. First, the relationship of formative evaluation to the range of special education assessment practice and its importance to the field are described. Then, four critical issues in…

  4. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... publish, in a scientific journal, material resulting directly or indirectly from work performed under this... in a journal article which has not been subjected to EPA review: “Although the research described in....” (3) Following publication of the journal article, the Contractor shall submit five copies of...

  5. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... publish, in a scientific journal, material resulting directly or indirectly from work performed under this... in a journal article which has not been subjected to EPA review: “Although the research described in....” (3) Following publication of the journal article, the Contractor shall submit five copies of...

  6. 33 CFR 51.9 - Discharge review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Armed Forces of the United States, along with any other statements, affidavits or documentation desired... writing to the Armed Forces Review/Correction Board Reading Room, Pentagon Concourse, Washington, DC 20310... the case was on the motion of the DRB; (2) Changes in discharge policy occur; or (3) New,...

  7. 33 CFR 51.9 - Discharge review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Armed Forces of the United States, along with any other statements, affidavits or documentation desired... writing to the Armed Forces Review/Correction Board Reading Room, Pentagon Concourse, Washington, DC 20310... the case was on the motion of the DRB; (2) Changes in discharge policy occur; or (3) New,...

  8. 33 CFR 51.9 - Discharge review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Armed Forces of the United States, along with any other statements, affidavits or documentation desired... writing to the Armed Forces Review/Correction Board Reading Room, Pentagon Concourse, Washington, DC 20310... the case was on the motion of the DRB; (2) Changes in discharge policy occur; or (3) New,...

  9. Limiting excessive postoperative blood transfusion after cardiac procedures. A review.

    PubMed Central

    Ferraris, V A; Ferraris, S P

    1995-01-01

    Analysis of blood product use after cardiac operations reveals that a few patients (< or = 20%) consume the majority of blood products (> 80%). The risk factors that predispose a minority of patients to excessive blood use include patient-related factors, transfusion practices, drug-related causes, and procedure-related factors. Multivariate studies suggest that patient age and red blood cell volume are independent patient-related variables that predict excessive blood product transfusion after cardiac procedures. Other factors include preoperative aspirin ingestion, type of operation, over- or underutilization of heparin during cardiopulmonary bypass, failure to correct hypothermia after cardiopulmonary bypass, and physician overtransfusion. A survey of the currently available blood conservation techniques reveals 5 that stand out as reliable methods: 1) high-dose aprotinin therapy, 2) preoperative erythropoietin therapy when time permits adequate dosage before operation, 3) hemodilution by harvest of whole blood immediately before cardiopulmonary bypass, 4) autologous predonation of blood, and 5) salvage of oxygenator blood after cardiopulmonary bypass. Other methods, such as the use of epsilon-aminocaproic acid or desmopressin, cell saving devices, reinfusion of shed mediastinal blood, and hemofiltration have been reported to be less reliable and may even be harmful in some high-risk patients. Consideration of the available data allows formulation of a 4-pronged plan for limiting excessive blood transfusion after surgery: 1) recognize the causes of excessive transfusion, including the importance of red blood cell volume, type of procedure being performed, preoperative aspirin ingestion, etc.; 2) establish a quality management program, including a survey of transfusion practices that emphasizes physician education and availability of real-time laboratory testing to guide transfusion therapy; 3) adopt a multimodal approach using institution-proven techniques; and

  10. Tooth-bleaching procedures and their controversial effects: A literature review

    PubMed Central

    Alqahtani, Mohammed Q.

    2014-01-01

    Aim This review article will help clinicians improve their understanding of the history of bleaching procedures, bleaching types, components, mechanisms, and their effects on soft tissue, tooth structures, resin composite, and bonding. Methods The controversial issues about bleaching procedures and their effects are reviewed. Additionally, the consequences of pre- and post-bleaching on the bonding potential of composite resin restorations to tooth structure are discussed. Conclusion The overall goal of the paper is to help reduce risks for patients. PMID:25408594

  11. 42 CFR 422.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Procedures before the Departmental Appeals Board on review. 422.1080 Section 422.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Appeal procedures...

  12. 42 CFR 498.85 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Procedures before the Departmental Appeals Board on review. 498.85 Section 498.85 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION APPEALS PROCEDURES FOR...

  13. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  14. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  15. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  16. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  17. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  18. Judgments of Restrictiveness, Social Acceptability, and Usage: Review of Research on Procedures to Decrease Behavior.

    ERIC Educational Resources Information Center

    Morgan, Robert L.

    1989-01-01

    The article reviewed research on professionals', consumers', and others' judgments of the restrictiveness, social acceptability, and estimated frequency of use of procedures to decrease problem behaviors of disabled persons. Most respondents agreed that more restrictive procedures should be used as a last resort and that less restrictive…

  19. A review: the application of minimally invasive surgery to pediatric urology: upper urinary tract procedures.

    PubMed

    Traxel, Erica J; Minevich, Eugene A; Noh, Paul H

    2010-07-01

    This paper is one-half of a 2 part review on minimally-invasive procedures in pediatric urology. This article focuses on upper tract procedures, including complete nephrectomy, partial nephrectomy, pyeloplasty, and ureterocalicostomy. We note important articles on pure laparoscopic as well as robotic-assisted laparoscopic upper urinary tract surgeries, concentrating on their techniques and outcomes.

  20. A review: the application of minimally invasive surgery to pediatric urology: lower urinary tract reconstructive procedures.

    PubMed

    Traxel, Erica J; Minevich, Eugene A; Noh, Paul H

    2010-07-01

    This paper is one-half of a 2 part review on minimally-invasive procedures in pediatric urology. This article focuses on lower tract procedures, including ureteroureterostomy, anti-reflux surgeries, creation of continent catheterizable channels, and augmentation cystoplasty. We note important articles on pure laparoscopic as well as robotic-assisted laparoscopic lower urinary tract surgeries, concentrating on their techniques and outcomes.

  1. Canopy Level Chlorophyll Fluorescence and the PRI in a Cornfield

    NASA Technical Reports Server (NTRS)

    Middleton, Elizabeth M.; Cheng, Yen-Ben; Corp, Lawrence A.; Campbell, Petya K. E.; Huemmrich, K. Fred; Zhang, Qingyuan; Kustas, William P.

    2012-01-01

    Two bio-indicators, the Photochemical Reflectance Index (PRI) and solar-induced red and far-red Chlorophyll Fluorescence (SIF), were derived from directional hyperspectral observations and studied in a cornfield on two contrasting days in the growing season. Both red and far-red SIF exhibited higher values on the day when the canopy in the early senescent stage, but only the far-red SIF showed sensitivity to viewing geometry. Consequently, the red/far-red SIF ratio varied greatly among azimuth positions while the largest values were obtained for the "hotspot" at both growth stages. This ratio was lower (approx.0.88 +/- 0.4) in early July than in August when the ratio approached equivalence (near approx.1). In concert, the PRI exhibited stronger responses to both zenith and azimuth angles and different values on the two growth stages. The potential of using these indices to monitor photosynthetic activities needs further investigation

  2. A review of the regenerative endodontic treatment procedure

    PubMed Central

    Lee, Bin-Na; Moon, Jong-Wook; Chang, Hoon-Sang; Hwang, In-Nam; Oh, Won-Mann

    2015-01-01

    Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment. PMID:26295020

  3. The Primitive Material Explorer (PriME) Mission

    NASA Astrophysics Data System (ADS)

    Cochran, Anita L.; Weaver, H. A.; Science, PriME; Engineering Teams

    2010-10-01

    The Primitive Material Explorer (PriME) Mission is a proposed Discovery mission that will rendezvous with comet 46P/Wirtanen in 2021 in order to 1) clarify the roles played by comets in the formation and evolution of the Solar System and the origin of life; 2) ascertain the bulk physical properties, the surface geology, and the sources of activity in a fresh comet nucleus; and 3) investigate the compositional diversity of primitive material in the Solar System. PriME teams an experienced group of comet scientists (led by PI Anita Cochran and by DPI Harold Weaver) with university and industrial partners. The PriME payload accomplishes the mission objectives with only three instruments. MASPEX (MAss Spectrometer for Planetary EXploration) has higher mass resolution and is more sensitive than any mass spectrometer ever flown. MASPEX will measure D/H in H2O, noble gases, isotopes of many species, and complex molecular compounds to test solar nebula models and the role comets played in delivering water and other biologically important materials throughout the Solar System. The VIS (Visible Imaging System), consisting of a Narrow Angle Camera (NAC) and Wide-Angle Camera (WAC), will constrain the conditions under which the building blocks of the outer Solar System were assembled by measuring key physical properties of the nucleus of 46P/Wirtanen. Using the radio antenna and close flybys of the nucleus, PriME will determine the mass of the nucleus to an accuracy of 1% and the bulk density and average porosity of the nucleus to better than 5%. All spacecraft subsystems have significant planetary flight heritage. The spacecraft is a high-heritage derivative of the Kepler and Deep Impact spacecrafts, compatible with the three launch vehicle families specified in the Discovery Announcement of Opportunity.

  4. 20 CFR 410.695 - Procedure before Appeals Council on review of hearing officer's decision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Procedure before Appeals Council on review of hearing officer's decision. 410.695 Section 410.695 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Disability, Other Determinations, Administrative Review, Finality of Decisions, and Representation of...

  5. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... COVERAGE DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review... than 90 days, by which the contractor completes the reconsideration; or (ii) For NCDs, in compliance...— (i) For LCDs, the 90-day reconsideration timeframe; or (ii) For NCDs, the reconsideration...

  6. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... COVERAGE DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review... than 90 days, by which the contractor completes the reconsideration; or (ii) For NCDs, in compliance...— (i) For LCDs, the 90-day reconsideration timeframe; or (ii) For NCDs, the reconsideration...

  7. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review of new evidence... contractor completes the reconsideration; or (ii) For NCDs, in compliance with the timeframes specified in... timeframe; or (ii) For NCDs, the reconsideration timeframe specified by the Board, in compliance...

  8. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review of new evidence... contractor completes the reconsideration; or (ii) For NCDs, in compliance with the timeframes specified in... timeframe; or (ii) For NCDs, the reconsideration timeframe specified by the Board, in compliance...

  9. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... COVERAGE DETERMINATIONS General Provisions for the Review of LCDs and NCDs § 426.340 Procedures for review... than 90 days, by which the contractor completes the reconsideration; or (ii) For NCDs, in compliance...— (i) For LCDs, the 90-day reconsideration timeframe; or (ii) For NCDs, the reconsideration...

  10. 15 CFR 400.32 - Procedure for review of request for approval of manufacturing or processing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Procedure for review of request for approval of manufacturing or processing. 400.32 Section 400.32 Commerce and Foreign Trade Regulations... REGULATIONS OF THE FOREIGN-TRADE ZONES BOARD Manufacturing and Processing Activity-Reviews § 400.32...

  11. 15 CFR 400.32 - Procedure for review of request for approval of manufacturing or processing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Procedure for review of request for approval of manufacturing or processing. 400.32 Section 400.32 Commerce and Foreign Trade Regulations... REGULATIONS OF THE FOREIGN-TRADE ZONES BOARD Manufacturing and Processing Activity-Reviews § 400.32...

  12. 15 CFR 400.32 - Procedure for review of request for approval of manufacturing or processing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Procedure for review of request for approval of manufacturing or processing. 400.32 Section 400.32 Commerce and Foreign Trade Regulations... REGULATIONS OF THE FOREIGN-TRADE ZONES BOARD Manufacturing and Processing Activity-Reviews § 400.32...

  13. Review of numerical procedures for computational surface thermochemistry

    NASA Technical Reports Server (NTRS)

    Milos, Frank S.; Rasky, Daniel J.

    1994-01-01

    Models and equations for surface thermochemistry and near-surface thermophysics of aerodynamically heated thermal protection materials are reviewed, with particular emphasis on computational boundary conditions for surface mass and energy transfer. The surface energy and mass balances, coupled with an appropriate ablation or surface catalysis model, provide complete thermochemical boundary conditions for a true multidisciplinary solution of the fully coupled fluid-dynamics/solid mechanics problem. Practical approximate solutions can be obtained by using a detailed model with full thermophysics for either the solid or fluid phase and a semianalytic method for the other half of the problem. A significant increase in the state-of-the-art in aerothermal computational fluid dynamics is possible by uniting computational fluid dynamic (CFD) methodology with surface thermochemistry boundary conditions and the heat-balance-integral method.

  14. A Review of Clinical Data for Currently Approved Hysteroscopic Sterilization Procedures

    PubMed Central

    Basinski, Cindy M

    2010-01-01

    Two hysteroscopic permanent sterilization procedures are approved for use in the United States: Essure® Permanent Birth Control System (Conceptus Incorporated, Mountain View, CA) and Adiana® Permanent Contraception (Hologic, Inc., Bedford, MA). This review compares the clinical trial data for these procedures. A notable difference is the resultant clinical pregnancy risk. The clinical trials for the Essure procedure have reported no pregnancies in 643 relying women in the 9 years since initiation of the studies. The clinical trial for the Adiana procedure has reported 12 pregnancies in 570 relying women in nearly 5 years of collected data. Other clinical outcome parameters concerning Essure and Adiana are examined in this review. PMID:21364861

  15. STS-34 crewmembers review IFM procedures on JSC's CCT mockup middeck

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-34 crewmembers review inflight maintenance (IFM) procedures on the middeck of JSC's crew compartment trainer (CCT) located in the Mockup and Integration Laboratory (MAIL) Bldg 9A. IFM trainer, holding cable, discusses procedures with Mission Specialist (MS) Ellen S. Baker (center) and Pilot Michael J. McCulley. An open stowage locker appears in front of the group. Visible on the mockup's middeck are forward and aft stowage lockers, the airlock hatch, and the starboard wall mounted sleep restraints.

  16. The Importance of PRI Therapy for the Pastoral Counsellor

    PubMed Central

    2009-01-01

    It is not always easy for pastoral counsellors to help people change. Often people have become stuck in their ways. Recent developments in the field of brain research help explain why change is difficult. This article discusses Past Reality Integration Therapy (PRI), a psychotherapeutic method that integrates recent findings of brain research and offers an important addition to the work of (pastoral) counsellors and psychotherapists. The use of this approach with Dutch students in their pastoral training is presented. Furthermore the importance of this new method for counsellors themselves, their clients and their work is discussed and some overall conclusions about the method and its practical application are presented. PMID:20835380

  17. Retinoids: Literature Review and Suggested Algorithm for Use Prior to Facial Resurfacing Procedures

    PubMed Central

    Buchanan, Patrick J; Gilman, Robert H

    2016-01-01

    Vitamin A-containing products have been used topically since the early 1940s to treat various skin conditions. To date, there are four generations of retinoids, a family of Vitamin A-containing compounds. Tretinoin, all-trans-retinoic acid, is a first-generation, naturally occurring, retinoid. It is available, commercially, as a gel or cream. The authors conducted a complete review of all studies, clinical- and basic science-based studies, within the literature involving tretinoin treatment recommendations for impending facial procedures. The literature currently lacks definitive recommendations for the use of tretinoin-containing products prior to undergoing facial procedures. Tretinoin pretreatment regimens vary greatly in terms of the strength of retinoid used, the length of the pre-procedure treatment, and the ideal time to stop treatment before the procedure. Based on the current literature and personal experience, the authors set forth a set of guidelines for the use of tretinoin prior to various facial procedures. PMID:27761082

  18. Impact of 3D Rotational Angiography on Liver Embolization Procedures: Review of Technique and Applications

    SciTech Connect

    Lucatelli, Pierleone Corona, Mario Argirò, Renato Anzidei, Michele; Vallati, Giulio; Fanelli, Fabrizio Bezzi, Mario Catalano, Carlo

    2015-06-15

    In the last years, the interest into interventional applications of C-arm cone-beam CT (CBCT) progressively raised, widening its clinical application from the original field of interventional neuroradiology to the field of peripheral procedures. Liver embolization procedures, due to their complexity and potential treatment-related life-threatening complications, represent one of the main clinical applications of this novel angiographic technique. CBCT has been demonstrated to render procedures safer and technically easier, and to predict outcome as well as to avoid major complications in different treatment scenarios (trans-arterial embolization, trans-arterial chemoembolization, selective internal radiation therapy, percutaneous portal vein embolization). This review summarizes all technical, dosimetric and procedural aspects of CBCT techniques, underlying all its potential clinical advantages in the field of liver embolization procedures. Moreover, the paper provides all the instructions to obtain the best diagnostic performance out of this novel angiographic technique.

  19. Application of carbon nanosorbent for PRiME pass-through cleanup of 10 selected local anesthetic drugs in human plasma samples.

    PubMed

    Ma, Jian-Bo; Zhao, Li-Ming; Rui, Qiu-Hong; Liao, Yu-Feng; Chen, Yan-Min; Xu, Jin; Zhu, Yan; Zhao, Yong-Gang

    2017-04-01

    A novel PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure has been developed to improve the existing commercially available designs. Carbon nanosorbents, i.e., magnetic modified carboxyl-graphene (Mag-CG) and magnetic modified carboxyl-carbon nanotubes (Mag-CCNTs), have been synthesised and evaluated in PRiME pass-through cleanup procedure for human plasma prior to analysis of 10 selected local anesthetic drugs by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS). The matrix effect, an interesting phenomenon of ion suppression for local anesthetic drugs containing ester group and ion enhancement for other drugs containing acylamino group, has been minimized using carbon nanosorbents PRiME pass-through cleanup procedure. Under the optimal conditions, the obtained results show higher cleanup efficiency of the carbon nanosorbents with recoveries between 70.2% and 126%. Furthermore, the carbon nanosorbents are also evaluated for reuse up to 80-100 times. The limits of quantification (LOQs) for local anesthetic drugs are in the range of 0.024-0.15 μg/L. Validation results on linearity, specificity, accuracy, and precision, as well as the application to the analysis of lidocaine in five patients recruited from the lung cancer demonstrate the applicability to clinical studies.

  20. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What are the procedures for using a multiple tier... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review...

  1. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false What are the procedures for using a multiple tier... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review...

  2. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false What are the procedures for using a multiple tier... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review...

  3. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false What are the procedures for using a multiple tier... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review...

  4. 34 CFR 75.224 - What are the procedures for using a multiple tier review process to evaluate applications?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false What are the procedures for using a multiple tier... procedures for using a multiple tier review process to evaluate applications? (a) The Secretary may use a multiple tier review process to evaluate applications. (b) The Secretary may refuse to review...

  5. 36 CFR 1260.42 - What are the procedures for agency personnel to review records at a NARA facility?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SECURITY INFORMATION Systematic Review § 1260.42 What are the procedures for agency personnel to review... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false What are the procedures for agency personnel to review records at a NARA facility? 1260.42 Section 1260.42 Parks, Forests, and...

  6. 36 CFR 1260.42 - What are the procedures for agency personnel to review records at a NARA facility?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SECURITY INFORMATION Systematic Review § 1260.42 What are the procedures for agency personnel to review... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false What are the procedures for agency personnel to review records at a NARA facility? 1260.42 Section 1260.42 Parks, Forests, and...

  7. Diffuse sky radiation influences the relationship between canopy PRI and shadow fraction

    NASA Astrophysics Data System (ADS)

    Mõttus, Matti; Takala, Tuure L. H.; Stenberg, Pauline; Knyazikhin, Yuri; Yang, Bin; Nilson, Tiit

    2015-07-01

    The Photochemical Reflectance Index (PRI) of green leaves is an indicator of photosynthetic downregulation: when the photosynthetic apparatus is close to the saturation limit, PRI becomes dependent on light conditions. Therefore, by measuring the PRI of leaves under different local irradiance conditions, it should be possible to determine the saturation level of the leaves and obtain information on the light use efficiency (LUE) of a vegetation canopy. The dependence of PRI on the ratio of sunlit to shaded foliage (quantified by the canopy shadow fraction) in the field of view of an instrument has been used to remotely measure canopy LUE on clear days. However, besides photosynthetic downregulation, the dependence of canopy PRI on shadow fraction is affected by the blue sky radiation caused by scattering in the atmosphere. To quantify this effect on remotely sensed PRI, we present the underlying definitions relating leaf and canopy PRI and perform the required calculations for typical midsummer conditions in Central Finland. We demonstrate that the effect of blue sky radiation on the variation of PRI with canopy shadow fraction is similar in shape and magnitude to that of LUE variations reported in literature.

  8. Three causes of variation in the photochemical reflectance index (PRI) in evergreen conifers.

    PubMed

    Wong, Christopher Y S; Gamon, John A

    2015-04-01

    The photochemical reflectance index (PRI) reflects diurnal xanthophyll cycle activity and is also influenced by seasonally changing carotenoid : Chl pigment ratios. Both changing pigment pools and xanthophyll cycle activity contribute to photoprotection in evergreen conifers exposed to boreal winters, but they operate over different timescales, and their relative contribution to the PRI signal has often been unclear. To clarify these responses and their contribution to the PRI signal, leaf PRI, pigment composition, temperature and irradiance were monitored over 2 yr for two evergreen conifers (Pinus contorta and Pinus ponderosa) in a boreal climate. PRI was affected by three distinct processes operating over different timescales and exhibiting contrasting spectral responses. Over the 2 yr study period, the greatest change in PRI resulted from seasonally changing carotenoid : Chl pigment ratios, followed by a previously unreported shifting leaf albedo during periods of deep cold. Remarkably, the smallest change was attributable to the xanthophyll cycle. To properly distinguish these three effects, interpretation of PRI must consider temporal context, physiological responses to evolving environmental conditions, and spectral response. Consideration of the separate mechanisms affecting PRI over different timescales could greatly improve efforts to monitor changing photosynthetic activity using optical remote sensing.

  9. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein.

    PubMed

    Wessel, Sarah R; Marceau, Aimee H; Massoni, Shawn C; Zhou, Ruobo; Ha, Taekjip; Sandler, Steven J; Keck, James L

    2013-06-14

    Frequent collisions between cellular DNA replication complexes (replisomes) and obstacles such as damaged DNA or frozen protein complexes make DNA replication fork progression surprisingly sporadic. These collisions can lead to the ejection of replisomes prior to completion of replication, which, if left unrepaired, results in bacterial cell death. As such, bacteria have evolved DNA replication restart mechanisms that function to reload replisomes onto abandoned DNA replication forks. Here, we define a direct interaction between PriC, a key Escherichia coli DNA replication restart protein, and the single-stranded DNA-binding protein (SSB), a protein that is ubiquitously associated with DNA replication forks. PriC/SSB complex formation requires evolutionarily conserved residues from both proteins, including a pair of Arg residues from PriC and the C terminus of SSB. In vitro, disruption of the PriC/SSB interface by sequence changes in either protein blocks the first step of DNA replication restart, reloading of the replicative DnaB helicase onto an abandoned replication fork. Consistent with the critical role of PriC/SSB complex formation in DNA replication restart, PriC variants that cannot bind SSB are non-functional in vivo. Single-molecule experiments demonstrate that PriC binding to SSB alters SSB/DNA complexes, exposing single-stranded DNA and creating a platform for other proteins to bind. These data lead to a model in which PriC interaction with SSB remodels SSB/DNA structures at abandoned DNA replication forks to create a DNA structure that is competent for DnaB loading.

  10. Improving the review of standard operating procedures: a novel electronic system for compounding pharmacies.

    PubMed

    Brensel, Robert; Brensel, Scott; Ng, Amy

    2013-01-01

    Since the New England Compounding Center disaster in 2012, the importance of following correct procedures during every phase of customized pharmacy has been a focus of governmental interest and action as well as public scrutiny. Many pharmacies rely on the rote review of standard operating procedures to ensure that staff members understand and follow protocols that ensure the safety and potency of all compounds prepared, but that approach to continuing education can be cumbersome and needlessly time-consuming. In addition, documenting and retrieving evidence of employee competence can be difficult. In this article, we describe our use of online technology to improve our methods of educating staff about the full range of standard operating procedures that must be followed in our pharmacy. The system we devised and implemented has proven to be effective, easy to update and maintain, very inexpensive, and user friendly. Its use has reduced the time previously required for a read-over review of standard operating procedures from 30 or 40 minutes to 5 or 10 minutes in weekly staff meetings, and we can now easily document and access proof of employees' comprehension of that content. It is our hope that other small compounding pharmacies will also find this system of online standard operating procedure review helpful.

  11. New insights into pri-miRNA processing and accumulation in plants.

    PubMed

    Zhang, Shuxin; Liu, Yuhui; Yu, Bin

    2015-01-01

    MicroRNAs (miRNAs) regulate many biological processes such as development, metabolism, and others. They are processed from their primary transcripts called primary miRNA transcripts (pri-miRNAs) by the processor complex containing the RNAse III enzyme, DICER-LIKE1 (DCL1), in plants. Consequently, miRNA biogenesis is controlled through altering pri-miRNA accumulation and processing, which is crucial for plant development and adaptation to environmental changes. Plant pri-miRNAs are transcribed by DNA-dependent RNA polymerase II (Pol II) and their levels are determined through transcription and degradation, whereas pri-miRNA processing is affected by its structure, splicing, alternative splicing, loading to the processor and the processor activity, which involve in many accessory proteins. Here, we summarize recent progresses related to pri-miRNA transcription, stability, and processing in plants.

  12. 77 FR 36532 - Review of Small Generator Interconnection Agreements and Procedures; Solar Energy Industries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ...-001; ER12-1855-000] Review of Small Generator Interconnection Agreements and Procedures; Solar Energy... discuss issues related to a petition for rulemaking recently submitted by the Solar Energy Industries... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY...

  13. Physical Restraint of People with Intellectual Disability: A Review of Implementation Reduction and Elimination Procedures

    ERIC Educational Resources Information Center

    Luiselli, James K.

    2009-01-01

    Background: This review describes procedures to reduce and eliminate physical restraint of people with intellectual disability. One approach is to assess antecedent conditions associated with restraint and change them so that they no longer produce restraint-provoking behaviour. A second approach is to decrease the duration of restraint by…

  14. 75 FR 50750 - Streamlined Procedure for Appeal Brief Review in Inter Partes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ..., 2010. David J. Kappos, Under Secretary of Commerce for Intellectual Property and Director of the United... United States Patent and Trademark Office Streamlined Procedure for Appeal Brief Review in Inter Partes Reexamination Proceedings AGENCY: United States Patent and Trademark Office, Commerce. ACTION: Notice....

  15. 7 CFR 658.7 - USDA assistance with Federal agencies' reviews of policies and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false USDA assistance with Federal agencies' reviews of policies and procedures. 658.7 Section 658.7 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES...

  16. 42 CFR 423.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Procedures before the Departmental Appeals Board on review. 423.1080 Section 423.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG...

  17. 42 CFR 422.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Procedures before the Departmental Appeals Board on review. 422.1080 Section 422.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM...

  18. 42 CFR 423.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Procedures before the Departmental Appeals Board on review. 423.1080 Section 423.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) VOLUNTARY MEDICARE PRESCRIPTION...

  19. 32 CFR 861.5 - DOD Commercial Airlift Review Board procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false DOD Commercial Airlift Review Board procedures. 861.5 Section 861.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE... consider reinstating a suspended carrier on either CARB motion or carrier motion, unless such carrier...

  20. 32 CFR 861.5 - DOD Commercial Airlift Review Board procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false DOD Commercial Airlift Review Board procedures. 861.5 Section 861.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE... consider reinstating a suspended carrier on either CARB motion or carrier motion, unless such carrier...

  1. A Review of Procedures for Analyzing Coherence in Written Language Samples.

    ERIC Educational Resources Information Center

    Irwin, Judith Westphal

    1982-01-01

    The article presents a critical review of procedures for analyzing coherence in written language samples. The psychological model of referential coherence, linguistic analysis of cohesion, and given/new contract are discussed in terms of research results, psychometric concerns, and writing research. Recommendations concerning their relative…

  2. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of...

  3. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of...

  4. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of...

  5. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT Application of Executive Order on Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of...

  6. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., Department of Housing and Urban Development FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS Application of Executive Orders on Floodplain Management and Protection of Wetlands § 55.10 Environmental review procedures... 58) of proposed actions in a floodplain or wetland. (b) The categorical exclusion of certain...

  7. A Qualitative Analysis of the Determinants in the Choice of a French Journal Reviewing Procedures

    ERIC Educational Resources Information Center

    Morge, Ludovic

    2015-01-01

    Between 1993 and 2010, two French journals (Aster and Didaskalia) coming from different backgrounds but belonging to the same institution used to publish papers on research in science and technology education. The merging of these journals made it necessary for them to compare the different reviewing procedures used by each. This merging occurred…

  8. 36 CFR 223.191 - Sourcing area disapproval and review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Sourcing area disapproval and review procedures. 223.191 Section 223.191 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER The Forest Resources...

  9. 15 CFR Supplement No. 9 to Part 748 - End-User Review Committee Procedures

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false End-User Review Committee Procedures No. Supplement No. 9 to Part 748 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT...

  10. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  11. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  12. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  13. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  14. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  15. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Procedures for issuing a decision on a registration review case. 155.58 Section 155.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... decision, the Agency will, among other things: (1) State its proposed findings with respect to the...

  16. A qualitative analysis of the determinants in the choice of a French journal reviewing procedures

    NASA Astrophysics Data System (ADS)

    Morge, Ludovic

    2015-12-01

    Between 1993 and 2010, two French journals (Aster and Didaskalia) coming from different backgrounds but belonging to the same institution used to publish papers on research in science and technology education. The merging of these journals made it necessary for them to compare the different reviewing procedures used by each. This merging occurred at a time when research is becoming increasingly international which partly determines some of the reviewing procedure choices. In order for a francophone international journal to survive, it needs to take this internationalization into account in a reasoned manner. The author of this article, as a chief editor of RDST (Recherches en Didactique des Sciences et des Technologies)—the journal resulting from the merging- taking part in this merger, analyses the social, cultural and pragmatic determinants which impacted the choices made in reviewing procedures. This paper describes how these diversity of factors leads us to drop the idea of a standard reviewing procedure which would be valid for all journals.

  17. 34 CFR 222.158 - What procedures apply to the Secretary's review of an initial decision?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What procedures apply to the Secretary's review of an initial decision? 222.158 Section 222.158 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION IMPACT AID PROGRAMS...

  18. 34 CFR 602.33 - Procedures for review of agencies during the period of recognition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Procedures for review of agencies during the period of recognition. 602.33 Section 602.33 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE SECRETARY'S RECOGNITION...

  19. Emergency Major Abdominal Surgical Procedures in Older Adults: A Systematic Review of Mortality and Functional Outcomes

    PubMed Central

    Cooper, Zara; Scott, John W.; Rosenthal, Ronnie A.; Mitchell, Susan L.

    2016-01-01

    OBJECTIVES To systematically review the current literature on mortality and functional outcomes after emergency major abdominal surgery in older adults. DESIGN Systematic literature search and standardized data collection of primary research publications from January 1994 through December 2013 on mortality or functional outcome in adults aged 65 and older after emergency major abdominal surgery using PubMed, EMBASE, Web of Science, Cochrane, and CINAHL. Bibliographies of relevant reports were also hand-searched to identify all potentially eligible studies. SETTING Systematic review of retrospective and cohort studies using Preferred Reporting Items for Systematic reviews and Meta-Analyses, Meta-analysis Of Observational Studies in Epidemiology, Strengthening the Reporting of Observational Studies in Epidemiology, and A Measurement Tool to Assess Systematic Reviews guidelines. PARTICIPANTS Older adults. MEASUREMENTS Articles were assessed using a standardized quality scoring system based on study design, measurement of exposures, measurement of outcomes, and control for confounding. RESULTS Of 1,459 articles screened, 93 underwent full-text review, and 20 were systematically reviewed. In-hospital and 30-day mortality of all older adults exceeded 15% in 14 of 16 studies, where reported. Older adults undergoing emergency major abdominal surgery consistently had higher mortality across study settings and procedure types than younger individuals undergoing emergency procedures and older adults undergoing elective procedures. In studies that stratified older adults, odds of death increased with age. None of these studies examined postoperative functional status, which precluded including functional outcomes in this review. Differences in exposures, outcomes, and data presented in the studies did not allow for quantification of association using metaanalysis. CONCLUSION Age independently predicts mortality after emergency major abdominal surgery. Data on changes in

  20. Literature Review of Cosmetic Procedures in Men: Approaches and Techniques are Gender Specific.

    PubMed

    Cohen, Brandon E; Bashey, Sameer; Wysong, Ashley

    2017-02-01

    The proportion of men receiving non-surgical cosmetic procedures has risen substantially in recent years. Various physiologic, anatomic, and motivational considerations differentiate the treatments for male and female patients. Nevertheless, research regarding approaches to the male cosmetic patient is scarce. We sought to provide an overview and sex-specific discussion of the most popular cosmetic dermatologic procedures pursued by men by conducting a comprehensive literature review pertaining to non-surgical cosmetic procedures in male patients. The most common and rapidly expanding non-surgical interventions in men include botulinum toxin, filler injection, chemical peels, microdermabrasion, laser resurfacing, laser hair removal, hair transplantation, and minimally invasive techniques for adipose tissue reduction. Important sex-specific factors associated with each of these procedures should be considered to best serve the male cosmetic patient.

  1. Non-Parenteral Medications for Procedural Sedation in Children- A Narrative: Review Article.

    PubMed

    Fallah, Razieh; Ferdosian, Farzad; Shajari, Ahmad

    2015-01-01

    Procedural sedation may be needed in many diagnostic and therapeutic procedures in children. To make pediatric procedural sedation as safe as possible, protocols should be developed by institutions. Response to sedation in children is highly variable, while some become deeply sedated after minimal doses, others may need much higher doses. Child developmental status, clinical circumstances and condition of patient should be considered and then pharmacologic and non-pharmacologic interventions for sedation be selected. Drug of choice and administration route depend on the condition of the child, type of procedure, and predicted pain degree. The drugs might be administered parenteral (intravenous or intramuscular) or non parenteral including oral, rectal, sublingual, aerosolized buccal and intranasal. The use of intravenous medication such propofol, ketamine, dexmedetomidine, or etomidate may be restricted in use by pediatric anesthesiologist or pediatric critical care specialists or pediatric emergency medicine specialists. In this review article we discuss on non-parenteral medications that can be used by non- anesthesiologist.

  2. Non-Parenteral Medications for Procedural Sedation in Children- A Narrative: Review Article

    PubMed Central

    FALLAH, Razieh; FERDOSIAN, Farzad; SHAJARI, Ahmad

    2015-01-01

    Procedural sedation may be needed in many diagnostic and therapeutic procedures in children. To make pediatric procedural sedation as safe as possible, protocols should be developed by institutions. Response to sedation in children is highly variable, while some become deeply sedated after minimal doses, others may need much higher doses. Child developmental status, clinical circumstances and condition of patient should be considered and then pharmacologic and non-pharmacologic interventions for sedation be selected. Drug of choice and administration route depend on the condition of the child, type of procedure, and predicted pain degree. The drugs might be administered parenteral (intravenous or intramuscular) or non parenteral including oral, rectal, sublingual, aerosolized buccal and intranasal. The use of intravenous medication such propofol, ketamine, dexmedetomidine, or etomidate may be restricted in use by pediatric anesthesiologist or pediatric critical care specialists or pediatric emergency medicine specialists. In this review article we discuss on non-parenteral medications that can be used by non- anesthesiologist. PMID:26401146

  3. Effectiveness of internet-based affect induction procedures: A systematic review and meta-analysis.

    PubMed

    Ferrer, Rebecca A; Grenen, Emily G; Taber, Jennifer M

    2015-12-01

    Procedures used to induce affect in a laboratory are effective and well-validated. Given recent methodological and technological advances in Internet research, it is important to determine whether affect can be effectively induced using Internet methodology. We conducted a meta-analysis and systematic review of prior research that has used Internet-based affect induction procedures, and examined potential moderators of the effectiveness of affect induction procedures. Twenty-six studies were included in final analyses, with 89 independent effect sizes. Affect induction procedures effectively induced general positive affect, general negative affect, fear, disgust, anger, sadness, and guilt, but did not significantly induce happiness. Contamination of other nontarget affect did not appear to be a major concern. Video inductions resulted in greater effect sizes. Overall, results indicate that affect can be effectively induced in Internet studies, suggesting an important venue for the acceleration of affective science. (PsycINFO Database Record

  4. Welfare implications of invasive piglet husbandry procedures, methods of alleviation and alternatives: a review.

    PubMed

    Sutherland, M A

    2015-01-01

    Iron administration, teeth clipping, tail docking and castration are common invasive husbandry procedures performed on piglets on commercial farms, generally within the first week of life. These procedures are performed to prevent potential health and welfare problems of piglets and/or the sow, or, with respect to castration, to enhance meat quality. The objectives of this review were firstly, to provide the rationale and scientific evidence for performing these procedures, secondly, to describe the welfare implications of these procedures, and lastly, to describe mitigation strategies or alternatives that can be used to eliminate or reduce the pain caused by these procedures. Administering supplementary iron is necessary to prevent anaemia in piglets and the procedure has a low welfare impact. The stated benefits of teeth clipping to prevent udder lesions do not appear to outweigh the risk from injury and infection in piglets following the procedure. Tail docking reduces the prevalence of tail biting, but does not eliminate this behaviour and the practice of tail docking can cause acute pain. Castration is primarily performed to reduce the occurrence of boar taint, but alternatives are now available that negate the need to perform this procedure. Teeth clipping, tail docking and castration all cause behavioural and physiological changes indicative of acute pain and can have potentially long-term negative consequences such as causing abscesses, lesions and the formation of neuromas. Therefore effective pain mitigation strategies (e.g. analgesia, local or general anaesthesia) that markedly alleviate the pain caused by these procedures are necessary to improve the welfare of piglets. Alternatively, if management practices are available that eliminate the need for performing these procedures altogether, then they should be adopted.

  5. Conceptual framework for drug usage review, medical audit and other patient care review procedures.

    PubMed

    Stolar, M H

    1977-02-01

    The following concepts are discussed: (1) quality assurance programs, (2) drug usage review, (3) utilization review, (4) peer review, (5) medical audit, (6) patient care audit and (7) medical care evaluation studies. A framework within which all types of hospital quality assurance mechanisms can be constructed is proposed and their interrelationships are described. The pharmacist's particpiation in the hospital's overall quality assurance program is stressed in two main areas-drug usage review, performed jointly with the medical staff, and quality assurance of pharmaceutical services, a peer review function of the pharmacy profession. These services are primarily drug distribution and control, drug information, clinical pharmacy, continuing education, and other pharmacy and pharmacist functions. Both functions may be viewed as parts of the pharmacy audit, one of several patient care audits within the facility. Pharmacists in skilled nursing facilities have quality assurance responsibilities similar to those of hospital-based pharmacists.

  6. Involvement of histidine in complex formation of PriB and single-stranded DNA.

    PubMed

    Fujiyama, Saki; Abe, Yoshito; Takenawa, Taichi; Aramaki, Takahiko; Shioi, Seijiro; Katayama, Tsutomu; Ueda, Tadashi

    2014-02-01

    PriB is a basic 10-kDa protein that acts as a facilitator in PriA-dependent replication restart in Escherichia coli. PriB has an OB-fold dimer structure and exhibits single-stranded DNA (ssDNA)-binding activities similar to single-stranded binding protein (SSB). In this study, we examined PriB's interaction with ssDNA (oligo-dT35, -dT15, and -dT7) using heteronuclear NMR analysis. Interestingly, (1)H or (15)N chemical shift changes of the PriB main-chain showed two distinct modes using oligo-dT35. The chemical shift perturbation sites in the primary mode were consistent with the main contact site in PriB-ssDNA, which was previously determined by crystal structure analysis. The results also suggested that approximately 8nt in ssDNA was the main contact site to PriB. In the secondary mode, residues in the α-helix region (His57-Ser65) and in β4-loop3-β5 were mainly perturbed. On the other hand, we examined the state of ssDNA by FRET using 5'-Cy3- and 3'-Cy5-modified oligo-dT35. As the PriB concentration increased, two-step saturation curves were observed in the FRET assay, suggesting a compact structure of ssDNA. Moreover, we confirmed two-step PriB binding to oligo-dT35 using EMSA. The pH dependence of FRET suggested contribution of the His residues. Therefore, we prepared His mutants of PriB and found that His64 in the α-helix region contributed to the second interaction between PriB and ssDNA using FRET and EMSA. Thus, from a structural standpoint, we suggested the role of His64 on the compactness of the PriB-ssDNA complex and on the positive cooperativity of PriB.

  7. Correcting the relationship between PRI and shadow fraction for the blue sky effect

    NASA Astrophysics Data System (ADS)

    Mõttus, Matti

    2016-04-01

    The Photochemical Reflectance Index (PRI) is defined as the normalized difference ratio of leaf reflectance at two specific wavelengths in the green spectral region. Its value depends on the status of leaf carotenoid content, and especially that of the xanthophyll cycle pigments. Due to the dependence on the xanthophyll cycle, when the photosynthetic apparatus of green leaves is close to the saturation limit, their PRI becomes dependent on light conditions. Therefore, by measuring the PRI of leaves in the same canopy under different local irradiance conditions on a sunny day, it should be possible to determine the saturation level of the leaves. In turn, this gives information on the light use efficiency (LUE) of the vegetation canopy. The average light conditions of visible foliage elements are often quantified with the shadow fraction -- the fraction of visible foliage not lit by direct sunlight. The dependence of PRI on the shadow fraction has been used to remotely measure canopy LUE on clear days. Variations in shadow fraction have been achieved with multiangular measurement. However, besides photosynthetic downregulation, the dependence of canopy PRI on shadow fraction is affected by the blue sky radiation caused by scattering in the atmosphere. To quantify this effect on remotely sensed PRI, we present the underlying definitions relating leaf and canopy PRI and perform the required calculations for typical midsummer conditions in Central Finland. We demonstrate that the effect of blue sky radiation on the variation of PRI with canopy shadow fraction is similar in shape and magnitude to that of LUE variations reported in literature. Next, we propose a new method to assess these PRI variations in structured vegetation. We investiagate this blue sky effect on the PRI -- shadow fraction relationship with high spatial (60 cm) and spectral (9.8 nm) resolution airborne imaging spectroscopy data from Hyytiälä, Finland. We evaluate the spectral irradiance in

  8. Dissemination of Periodontal Pathogens in the Bloodstream after Periodontal Procedures: A Systematic Review

    PubMed Central

    Horliana, Anna Carolina Ratto Tempestini; Chambrone, Leandro; Foz, Adriana Moura; Artese, Hilana Paula Carillo; Rabelo, Mariana de Sousa; Pannuti, Cláudio Mendes; Romito, Giuseppe Alexandre

    2014-01-01

    Background To date, there is no compilation of evidence-based information associating bacteremia and periodontal procedures. This systematic review aims to assess magnitude, duration, prevalence and nature of bacteremia caused by periodontal procedures. Study Design Systematic Review Types of Studies Reviewed MEDLINE, EMBASE and LILACS databases were searched in duplicate through August, 2013 without language restriction. Observational studies were included if blood samples were collected before, during or after periodontal procedures of patients with periodontitis. The methodological quality was assessed in duplicate using the modified Newcastle-Ottawa scale (NOS). Results Search strategy identified 509 potentially eligible articles and nine were included. Only four studies demonstrated high methodological quality, whereas five were of medium or low methodological quality. The study characteristics were considered too heterogeneous to conduct a meta-analysis. Among 219 analyzed patients, 106 (49.4%) had positive bacteremia. More frequent bacteria were S. viridans, A. actinomycetemcomitans P. gingivalis, M. micros and species Streptococcus and Actinomyces, although identification methods of microbiologic assays were different among studies. Clinical Implications Although half of the patients presented positive bacteremia after periodontal procedures, accurate results regarding the magnitude, duration and nature of bacteremia could not be confidentially assessed. PMID:24870125

  9. 16 CFR 1028.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Expedited review procedures for certain....110 Section 1028.110 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF HUMAN SUBJECTS § 1028.110 Expedited review procedures for certain kinds of research involving no...

  10. 7 CFR 1c.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... an expedited review procedure shall adopt a method for keeping all members advised of research... research involving no more than minimal risk, and for minor changes in approved research. 1c.110 Section 1c... review procedures for certain kinds of research involving no more than minimal risk, and for...

  11. 75 FR 29996 - Review of MMS NEPA Policies, Practices, and Procedures for OCS Oil and Gas Exploration and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... (OCS) oil and gas exploration and development. This review of MMS NEPA policies, practices and procedures is being conducted as a result of the oil spill from the Deepwater Horizon well and drilling rig... QUALITY Review of MMS NEPA Policies, Practices, and Procedures for OCS Oil and Gas Exploration...

  12. Monitoring seasonal and diurnal changes in photosynthetic pigments with automated PRI and NDVI sensors

    NASA Astrophysics Data System (ADS)

    Gamon, J. A.; Kovalchuck, O.; Wong, C. Y. S.; Harris, A.; Garrity, S. R.

    2015-07-01

    The vegetation indices normalized difference vegetation index (NDVI) and photochemical reflectance index (PRI) provide indicators of pigmentation and photosynthetic activity that can be used to model photosynthesis from remote sensing with the light-use-efficiency model. To help develop and validate this approach, reliable proximal NDVI and PRI sensors have been needed. We tested new NDVI and PRI sensors, "spectral reflectance sensors" (SRS sensors; recently developed by Decagon Devices, during spring activation of photosynthetic activity in evergreen and deciduous stands. We also evaluated two methods of sensor cross-calibration - one that considered sky conditions (cloud cover) at midday only, and another that also considered diurnal sun angle effects. Cross-calibration clearly affected sensor agreement with independent measurements, with the best method dependent upon the study aim and time frame (seasonal vs. diurnal). The seasonal patterns of NDVI and PRI differed for evergreen and deciduous species, demonstrating the complementary nature of these two indices. Over the spring season, PRI was most strongly influenced by changing chlorophyll : carotenoid pool sizes, while over the diurnal timescale, PRI was most affected by the xanthophyll cycle epoxidation state. This finding demonstrates that the SRS PRI sensors can resolve different processes affecting PRI over different timescales. The advent of small, inexpensive, automated PRI and NDVI sensors offers new ways to explore environmental and physiological constraints on photosynthesis, and may be particularly well suited for use at flux tower sites. Wider application of automated sensors could lead to improved integration of flux and remote sensing approaches for studying photosynthetic carbon uptake, and could help define the concept of contrasting vegetation optical types.

  13. Monitoring seasonal and diurnal changes in photosynthetic pigments with automated PRI and NDVI sensors

    NASA Astrophysics Data System (ADS)

    Gamon, J. A.; Kovalchuk, O.; Wong, C. Y. S.; Harris, A.; Garrity, S. R.

    2015-02-01

    The vegetation indices normalized difference vegetation index (NDVI) and photochemical reflectance index (PRI) provide indicators of pigmentation and photosynthetic activity that can be used to model photosynthesis from remote sensing with the light-use efficiency model. To help develop and validate this approach, reliable proximal NDVI and PRI sensors have been needed. We tested new NDVI and PRI sensors, "SRS" sensors recently developed by Decagon Devices, during spring activation of photosynthetic activity in evergreen and deciduous stands. We also evaluated two methods of sensor cross-calibration, one that considered sky conditions (cloud cover) at midday only, and the other that also considered diurnal sun angle effects. Cross-calibration clearly affected sensor agreement with independent measurements, with the best method dependent upon the study aim and time frame (seasonal vs. diurnal). The seasonal patterns of NDVI and PRI differed for evergreen and deciduous species, demonstrating the complementary nature of these two indices. Over the spring season, PRI was most strongly influenced by changing chlorophyll : carotenoid pool sizes, while over the diurnal time scale PRI was most affected by the xanthophyll cycle epoxidation state. This finding demonstrates that the SRS PRI sensors can resolve different processes affecting PRI over different time scales. The advent of small, inexpensive, automated PRI and NDVI sensors offers new ways to explore environmental and physiological constraints on photosynthesis, and may be particularly well-suited for use at flux tower sites. Wider application of automated sensors could lead to improved integration of flux and remote sensing approaches to studying photosynthetic carbon uptake, and could help define the concept of contrasting vegetation optical types.

  14. Report: EPA’s Review of Applications for a Water Research Grant Did Not Follow All Review Procedures and Lacked Transparency

    EPA Pesticide Factsheets

    Report #12-P-0864, September 25, 2012. NCER did not follow all applicable policies and procedures in reviewing applications submitted under RFA EPA-G2009-STAR-F1, and lacked procedures for a key aspect of its STAR grant application peer review process.

  15. REVIEW Of COMPUTERIZED PROCEDURE GUIDELINES FOR NUCLEAR POWER PLANT CONTROL ROOMS

    SciTech Connect

    David I Gertman; Katya Le Blanc; Ronald L Boring

    2011-09-01

    Computerized procedures (CPs) are recognized as an emerging alternative to paper-based procedures for supporting control room operators in nuclear power plants undergoing life extension and in the concept of operations for advanced reactor designs. CPs potentially reduce operator workload, yield increases in efficiency, and provide for greater resilience. Yet, CPs may also adversely impact human and plant performance if not designed and implemented properly. Therefore, it is important to ensure that existing guidance is sufficient to provide for proper implementation and monitoring of CPs. In this paper, human performance issues were identified based on a review of the behavioral science literature, research on computerized procedures in nuclear and other industries, and a review of industry experience with CPs. The review of human performance issues led to the identification of a number of technical gaps in available guidance sources. To address some of the gaps, we developed 13 supplemental guidelines to support design and safety. This paper presents these guidelines and the case for further research.

  16. Corticotomies as a surgical procedure to accelerate tooth movement during orthodontic treatment: A systematic review

    PubMed Central

    Fernández-Ferrer, Laura; Montiel-Company, José-María; Candel-Martí, Eugenia; Almerich-Silla, José-Manuel; Peñarrocha-Diago, Miguel

    2016-01-01

    Background One of the main aims of orthodontists is to reduce the treatment time as much as possible, particularly in view of the rise in demand for orthodontic treatment among adult patients. The objective of this systematic review was to examine the effectiveness of corticotomy as a surgical procedure that accelerates orthodontic tooth movement, together with its possible adverse effects. Material and Methods A systematic review of articles in 4 databases, Pubmed, Cochrane, Scopus and Embase, complemented by a manual search, identified 772 articles. The duplicates were eliminated and a critical reading of titles and abstracts led to the rejection of articles that did not meet the objectives of the review, leaving 69. After reading the full text of these articles, 49 were excluded because they did not meet the inclusion criteria. On applying the CONSORT criteria as a quality filter, a further 4 were eliminated due to low quality. Finally, 16 articles (4 systematic reviews and 12 controlled trials) were reviewed. Results All the studies agree that corticotomy prior to orthodontic treatment accelerates dental movement, reducing the treatment time. With regard to side-effects, no periodontal damage was found, although this was only studied in the short term. Conclusions The evidence regarding the results of corticotomy is limited, given the small number of quality clinical studies available. Before this procedure is included as a routine practice in dental surgeries, studies of higher methodological quality are required, studying a greater number of individuals and examining the possible long-term adverse effects and the cost/benefit of the procedure. Key words:Corticotomy, orthodontics, adults, accelerated tooth movement, osteotomy. PMID:27475698

  17. Review of Test Procedure for Determining HSPFs of Residential Variable-Speed Heat Pumps

    SciTech Connect

    Rice, C. Keith; Munk, Jeffrey D.; Shrestha, Som S.

    2015-08-01

    This report reviews the suitability of the existing Heating Seasonal Performance Factor (HSPF) ratings and testing requirements for the current generation of variable-speed (VS) air-source heat pumps. Recent field test results indicate larger discrepancies between rated HSPF and field-observed HSPF for VS models than for single-speed models in the same houses. These findings suggest that the heating season test and ratings procedure should be revisited for VS heat pumps. The ratings and testing procedures are described in ANSI/AHRI 210/240 (2008) for single-speed, two-capacity, and variable-speed units. Analysis of manufacturer and independent test performance data on VS units reveals why the current VS testing/ratings procedure results in overly optimistic HSPF ratings for some VS units relative to other types of heat pumps. This is due to a combination of extrapolation of low speed test data beyond the originally anticipated ambient temperature operating range and the constraints of unit controls, which prevent low speed operation over the range of ambient temperatures assumed in the procedure for low speed. As a result, the HSPFs of such units are being overpredicted relative to those for single- and two-capacity designs. This overprediction has been found to be significantly reduced by use in the HSPF ratings procedure of an alternative higher-load heating load line, described in a companion report (Rice et al., 2015).

  18. Microprocessor dynamics shows co- and post-transcriptional processing of pri-miRNAs.

    PubMed

    Louloupi, Annita; Ntini, Evgenia; Liz, Julia; Ørom, Ulf Andersson

    2017-03-01

    miRNAs are small regulatory RNAs involved in the regulation of translation of target transcripts. miRNA biogenesis is a multi-step process starting with the cleavage of the primary miRNA transcript in the nucleus by the Microprocessor complex. Endogenous processing of pri-miRNAs is challenging to study and the in vivo kinetics of this process is not known. Here, we present a method for determining the processing kinetics of pri-miRNAs within intact cells over time using a pulse-chase approach to label transcribed RNA during 15 minutes and follow the processing within a 1-hour window after labeling with bromouridine. We show, that pri-miRNAs exhibit different processing kinetics ranging from fast over intermediate to slow processing and provide evidence that pri-miRNA processing can occur both co-transcriptionally and post-transcriptionally.

  19. Advanced human-system interface design review guideline. Evaluation procedures and guidelines for human factors engineering reviews

    SciTech Connect

    O`Hara, J.M.; Brown, W.S.; Baker, C.C.; Welch, D.L.; Granda, T.M.; Vingelis, P.J.

    1994-07-01

    Advanced control rooms will use advanced human-system interface (HSI) technologies that may have significant implications for plant safety in that they will affect the operator`s overall role in the system, the method of information presentation, and the ways in which operators interact with the system. The U.S. Nuclear Regulatory Commission (NRC) reviews the HSI aspects of control rooms to ensure that they are designed to good human factors engineering principles and that operator performance and reliability are appropriately supported to protect public health and safety. The principal guidance available to the NRC, however, was developed more than ten years ago, well before these technological changes. Accordingly, the human factors guidance needs to be updated to serve as the basis for NRC review of these advanced designs. The purpose of this project was to develop a general approach to advanced HSI review and the human factors guidelines to support. NRC safety reviews of advanced systems. This two-volume report provides the results of the project. Volume I describes the development of the Advanced HSI Design Review Guideline (DRG) including (1) its theoretical and technical foundation, (2) a general model for the review of advanced HSIs, (3) guideline development in both hard-copy and computer-based versions, and (4) the tests and evaluations performed to develop and validate the DRG. Volume I also includes a discussion of the gaps in available guidance and a methodology for addressing them. Volume 2 provides the guidelines to be used for advanced HSI review and the procedures for their use.

  20. Structure and Function of the PriC DNA Replication Restart Protein.

    PubMed

    Wessel, Sarah R; Cornilescu, Claudia C; Cornilescu, Gabriel; Metz, Alice; Leroux, Maxime; Hu, Kaifeng; Sandler, Steven J; Markley, John L; Keck, James L

    2016-08-26

    Collisions between DNA replication complexes (replisomes) and barriers such as damaged DNA or tightly bound protein complexes can dissociate replisomes from chromosomes prematurely. Replisomes must be reloaded under these circumstances to avoid incomplete replication and cell death. Bacteria have evolved multiple pathways that initiate DNA replication restart by recognizing and remodeling abandoned replication forks and reloading the replicative helicase. In vitro, the simplest of these pathways is mediated by the single-domain PriC protein, which, along with the DnaC helicase loader, can load the DnaB replicative helicase onto DNA bound by the single-stranded DNA (ssDNA)-binding protein (SSB). Previous biochemical studies have identified PriC residues that mediate interactions with ssDNA and SSB. However, the mechanisms by which PriC drives DNA replication restart have remained poorly defined due to the limited structural information available for PriC. Here, we report the NMR structure of full-length PriC from Cronobacter sakazakii PriC forms a compact bundle of α-helices that brings together residues involved in ssDNA and SSB binding at adjacent sites on the protein surface. Disruption of these interaction sites and of other conserved residues leads to decreased DnaB helicase loading onto SSB-bound DNA. We also demonstrate that PriC can directly interact with DnaB and the DnaB·DnaC complex. These data lead to a model in which PriC acts as a scaffold for recruiting DnaB·DnaC to SSB/ssDNA sites present at stalled replication forks.

  1. 36 CFR 1260.58 - What are the procedures for requesting a mandatory review of White House originated information?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... more than 25 years old, NARA will review the records using systematic declassification guidance... requesting a mandatory review of White House originated information? 1260.58 Section 1260.58 Parks, Forests... NATIONAL SECURITY INFORMATION Mandatory Review § 1260.58 What are the procedures for requesting a...

  2. mirEX: a platform for comparative exploration of plant pri-miRNA expression data.

    PubMed

    Bielewicz, Dawid; Dolata, Jakub; Zielezinski, Andrzej; Alaba, Sylwia; Szarzynska, Bogna; Szczesniak, Michal W; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia; Karlowski, Wojciech M

    2012-01-01

    mirEX is a comprehensive platform for comparative analysis of primary microRNA expression data. RT-qPCR-based gene expression profiles are stored in a universal and expandable database scheme and wrapped by an intuitive user-friendly interface. A new way of accessing gene expression data in mirEX includes a simple mouse operated querying system and dynamic graphs for data mining analyses. In contrast to other publicly available databases, the mirEX interface allows a simultaneous comparison of expression levels between various microRNA genes in diverse organs and developmental stages. Currently, mirEX integrates information about the expression profile of 190 Arabidopsis thaliana pri-miRNAs in seven different developmental stages: seeds, seedlings and various organs of mature plants. Additionally, by providing RNA structural models, publicly available deep sequencing results, experimental procedure details and careful selection of auxiliary data in the form of web links, mirEX can function as a one-stop solution for Arabidopsis microRNA information. A web-based mirEX interface can be accessed at http://bioinfo.amu.edu.pl/mirex.

  3. Retrospective review of Contura HDR breast cases to improve our standardized procedure

    SciTech Connect

    Iftimia, Ileana; Cirino, Eileen T.; Ladd, Ron; Mower, Herbert W.; McKee, Andrea B.

    2013-07-01

    To retrospectively review our first 20 Contura high dose rate breast cases to improve and refine our standardized procedure and checklists. We prepared in advance checklists for all steps, developed an in-house Excel spreadsheet for second checking the plan, and generated a procedure for efficient contouring and a set of optimization constraints to meet the dose volume histogram criteria. Templates were created in our treatment planning system for structures, isodose levels, optimization constraints, and plan report. This study reviews our first 20 high dose rate Contura breast treatment plans. We followed our standardized procedure for contouring, planning, and second checking. The established dose volume histogram criteria were successfully met for all plans. For the cases studied here, the balloon-skin and balloon-ribs distances ranged between 5 and 43 mm and 1 and 33 mm, respectively; air{sub s}eroma volume/PTV{sub E}val volume≤5.5% (allowed≤10%); asymmetry<1.2 mm (goal≤2 mm); PTV{sub E}val V90%≥97.6%; PTV{sub E}val V95%≥94.9%; skin max dose≤98%Rx; ribs max dose≤137%Rx; V150%≤29.8 cc; V200%≤7.8 cc; the total dwell time range was 225.4 to 401.9 seconds; and the second check agreement was within 3%. Based on this analysis, more appropriate ranges for the total dwell time and balloon diameter tolerance were found. Three major problems were encountered: balloon migration toward the skin for small balloon-to-skin distances, lumen obstruction, and length change for the flexible balloon. Solutions were found for these issues and our standardized procedure and checklists were updated accordingly. Based on our review of these cases, the use of checklists resulted in consistent results, indicating good coverage for the target without sacrificing the critical structures. This review helped us to refine our standardized procedure and update our checklists.

  4. A systematic review of the impact of volume of surgery and specialization in Norwood procedure

    PubMed Central

    2014-01-01

    Background The volume-outcome relationship is supposed to be stronger in high risk, low volume procedures. The aim of this systematic review is to examine the available literature on the effects of hospital and surgeon volume, specialization and regionalization on the outcomes of the Norwood procedure. Methods A systematic literature search was performed in Medline, Embase, and the Cochrane Library. On the basis of titles and abstracts, articles of comparative studies were obtained in full-text in case of potential relevance and assessed for eligibility according to predefined inclusion criteria. All relevant data on study design, patient characteristics, hospital volume, surgeon volume and other institutional characteristics, as well as results were extracted in standardized tables. Study selection, data extraction and critical appraisal were carried out independently by two reviewers. Results We included 10 studies. All but one study had an observational design. The number of analyzed patients varied from 75 to 2555. Overall, the study quality was moderate with a huge number of items with an unclear risk of bias. All studies investigating hospital volume indicated a hospital volume-outcome relationship, most of them even having significant results. The results were very heterogeneous for surgeon volume. Conclusions The volume-outcome relationship in the Norwood procedure can be supported. However, the magnitude of the volume effect is difficult to assess. PMID:25096305

  5. Effect and evaluation of prying action for top- and seat-angle connections

    NASA Astrophysics Data System (ADS)

    Ahmed, Ali; Hasan, Rafiq

    2015-06-01

    Nonlinear finite element (FE) static analyses of top- and seat-angle connections were performed using ABAQUS standard to investigate the influence of connection parameters and its properties on prying action developed due to the interaction between column flange and top angle's vertical leg. Contact phenomenon between two interfaces with finite sliding and bolt pretension in the initial step of analysis was considered in the FE model. FE analysis results were compared with the experimental ones to examine the applicability of the FE model. Then, the location of plastic hinges in connection assemblages was investigated at the ultimate state of the connection and a parametric study was performed varying connection parameters, material properties of connection assemblages, and magnitude of bolt pretension to visualize their effects on prying force and on the position of prying force on top angle's vertical leg. Current study shows that plastic hinges not only develop at top angle's heel and bolt hole region but also in the bolt shank that differs from some assumptions of power model (Kishi and Chen 1990): (1) top angle thickness and gage distance from angle heel to bolt hole center line have an distinct effect on prying action; and (2) distributed prying force developed near the region of the top edge of tension angle's leg adjacent to column flange can contribute to the failure of the connection. Finally, a mathematical formulation to identify the location of prying force action point is proposed.

  6. Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety

    PubMed Central

    Absalom, Anthony; van Minnen, Baucke; Vissink, Arjan

    2017-01-01

    Objectives To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation. Materials and Methods We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine and midazolam for procedural sedation up to June 20, 2016. Inclusion criteria: clinical trial, human subjects, adult subjects (≥18 years), article written in English, German, French or Dutch, use of study medication for conscious sedation and at least one group receiving dexmedetomidine and one group receiving midazolam. Exclusion criteria: patients in intensive care, pediatric subjects and per protocol use of additional sedative medication other than rescue medication. Outcome measures for efficacy comparison were patient and clinician satisfaction scores and pain scores; outcome measures for safety comparison were hypotension, hypoxia, and circulatory and respiratory complications. Results We identified 89 papers, of which 12 satisfied the inclusion and exclusion criteria; 883 patients were included in these studies. Dexmedetomidine was associated with higher patient and operator satisfaction than midazolam. Patients receiving dexmedetomidine experienced less pain and had lower analgesic requirements. Respiratory and hemodynamic safety were similar. Conclusions Dexmedetomidine is a promising alternative to midazolam for use in procedural sedation. Dexmedetomidine provides more comfort during the procedure for the patient and clinician. If carefully titrated, the safety profiles are similar. PMID:28107373

  7. Positive Peer Reporting in the Classroom: a Review of Intervention Procedures.

    PubMed

    Murphy, Jillian; Zlomke, Kimberly

    2014-10-01

    Positive peer reporting (PPR) is a classroom-based intervention to improve social interactions between students using rewards and positive social attention. Along with a variant of the procedure referred to as "Tootling," PPR has demonstrated overwhelmingly positive results since its development. However, a unified, standard protocol for successful implementation of PPR interventions has not yet been established. A review of 24 studies, including 48 separately described cases of PPR in classroom settings, provided information concerning adaptations for students in special education, alternative school, and mainstream classrooms. Student participants ranged from preschool (age 4) to eighth grade (age 16). This paper summarizes the common procedural components found across cases described in the studies. A comparison of PPR-based interventions reported in the literature by various research teams also revealed differences in the procedures for targeting individuals or groups, providing training and support, allocating rewards, proceeding with daily peer report sessions, and terminating the intervention. Variations in specific procedural elements that may relate to PPR's effectiveness are discussed. The authors also provide suggestions to guide and support the advancement of standardized methods of PPR for future research and clinical application.

  8. Application of mesenchymal stem cells in bone regenerative procedures in oral implantology. A literature review

    PubMed Central

    Viña, Jose A.; El-Alami, Marya; Gambini, Juan; Borras, Consuelo; Viña, Jose

    2014-01-01

    Objective: The aim of this work was to review de literature about the role of mesenchymal stem cells in bone regenerative procedures in oral implantology, specifically, in the time require to promote bone regeneration. Study Design: A bibliographic search was carried out in PUBMED with a combination of different key words. Animal and human studies that assessed histomorphometrically the influence of mesenchymal stem cells on bone regeneration procedures in oral implantology surgeries were examined. Reults: - Alveolar regeneration: Different controlled histomorphometric animal studies showed that bone regeneration is faster using stem cells seeded in scaffolds than using scaffolds or platelet rich plasma alone. Human studies revealed that stem cells increase bone regeneration. - Maxillary sinus lift: Controlled studies in animals and in humans showed higher bone regeneration applying stem cells compared with controls. - Periimplantary bone regeneration and alveolar distraction: Studies in animals showed higher regeneration when stem cells are used. In humans, no evidence of applying mesenchymal stem cells in these regeneration procedures was found. Conclusion: Stem cells may promote bone regeneration and be useful in bone regenerative procedures in oral implantology, but no firm conclusions can be drawn from the rather limited clinical studies so far performed. Key words:Mesenchymal stem cells, bone regeneration, dental implants, oral surgery, tissue engineering. PMID:24596637

  9. Review of procedures used for the extraction of anti-cancer compounds from tropical plants.

    PubMed

    Pandey, Saurabh; Shaw, Paul N; Hewavitharana, Amitha K

    2015-01-01

    Tropical plants are important sources of anti-cancer lead molecules. According to the US National Cancer Institute, out of the 3000 plants identified as active against cancer using in vitro studies, 70% are of tropical origin. The extraction of bioactive compounds from the plant materials is a fundamental step whose efficiency is critical for the success of drug discovery efforts. There has been no review published of the extraction procedures of anti-cancer compounds from tropical plants and hence the following is a critical evaluation of such procedures undertaken prior to the use of these compounds in cancer cell line studies, during the last five years. It presents a comprehensive analysis of all approaches taken to extract anti-cancer compounds from various tropical plants. (Databases searched were PubMed, SciFinder, Web of Knowledge, Scopus, Embase and Google Scholar).

  10. Review of data analysis procedures for the ATS-6 millimeter wave experiment

    NASA Technical Reports Server (NTRS)

    Meneghini, R.

    1975-01-01

    Predictions of satellite downlink attenuation through the use of ground based measurements form a substantial part of the ATS-6 millimeter wave experiment (MWE). At the downlink frequencies (20 and 30 GHz), the major causes of attenuation are the density and the size distribution of rain drops along the propagation path. Ground station data, which include radar and rain gauge records, measure quantities related to the meteorological parameters of interest and thereby provide a prediction of downlink attenuation with which the measured attenuation can be compared. The calibration and data analysis procedures used in the MWE are reviewed with the object of improving the accuracy of such ground based predictions.

  11. Pain and anxiety management for pediatric dental procedures using various combinations of sedative drugs: A review.

    PubMed

    Gazal, Giath; Fareed, Wamiq Musheer; Zafar, Muhammad Sohail; Al-Samadani, Khalid H

    2016-07-01

    For fearful and uncooperative children behavioral management techniques are used. In order to control the pain and anxiety in pedodontic patients, pharmacologic sedation, anesthesia and analgesia are commonly used. Midazolam is commonly used as an oral sedation agent in children; it has several features such as safety of use, quick onset and certain degree of amnesia that makes it a desirable sedation agent in children. This review paper discusses various aspects of oral midazolam, ketamine and their combinations in conscious sedation including, advantages of oral route of sedation, pharmacokinetics, range of oral doses, and antagonists for clinical dental treatment procedures.

  12. A retrospective case note review of laparoscopic versus open reversal of Hartmann’s procedure

    PubMed Central

    Yeomans, NP

    2014-01-01

    Introduction First described in 1921, Hartmann’s procedure is the gold standard treatment for complicated sigmoid diverticular disease. It is also used commonly for other causes of perforation of the large bowel. However, the reversal rate in the UK is much lower than in comparable countries, at only 18–22%. Furthermore, laparoscopic reversal (LRH) is used far less frequently than open reversal (ORH) despite evidence that a laparoscopic technique reduces patient morbidity and decreases patient recovery time. Methods This retrospective case note review undertook an analysis of all the patients who had undergone Hartmann’s procedure at two centres in Leeds Teaching Hospitals NHS Trust between February 2007 and February 2012. Out of 305 patients, 235 were identified and included in the analysis. Comparisons were then drawn between LRH and ORH groups. Results The reversal rate was 21%. Three-quarters (76%) were performed using an open technique, 20% were laparoscopic and 5% were converted to an open procedure. The mean hospital stay was longer for the ORH group (9.82 days, standard deviation [SD]: 5.85 days, 95% confidence interval [CI]: 2.99 days) than for the LRH group (7.29 days, SD: 4.65 days, 95% CI: 11.58 days) p=0.006). Seven ORH patients (21%) were reoperated but only one LRH patient (13%) had a reoperation at six months. Five factors were found to have a significant effect on the likelihood of reversal of Hartmann’s procedure. Conclusions The overall reversal rate for Hartmann’s procedure remains low. Shorter hospital stays, lower 6-month reoperation rates and reduced 30-day complication rates are associated with LRH when compared with ORH. PMID:25245735

  13. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain... be amended, as appropriate after consultation with other departments and agencies, through...

  14. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain... be amended, as appropriate after consultation with other departments and agencies, through...

  15. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain... be amended, as appropriate after consultation with other departments and agencies, through...

  16. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain... be amended, as appropriate after consultation with other departments and agencies, through...

  17. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for certain... be amended, as appropriate after consultation with other departments and agencies, through...

  18. Ravitch versus Nuss procedure for pectus excavatum: systematic review and meta-analysis

    PubMed Central

    Kanagaratnam, Aran; Phan, Steven; Tchantchaleishvilli, Vakhtang

    2016-01-01

    Background Pectus excavatum is the most common congenital chest wall deformity. The two most common surgical techniques for its correction are the modified Ravitch technique and the minimally invasive Nuss technique. Despite both procedures being used widely, data comparing them are scarce. Methods We conducted a systematic review and meta-analysis of comparative studies to evaluate these procedures. A systematic search of the literature was performed from six electronic databases. Pooled meta-analysis was conducted using odds ratio (OR) and weighted mean difference (WMD). Results A total of 13 studies comprising 1,432 pediatric (79.3%) and adult (20.7%) patients were identified, including 912 patients undergoing the Nuss procedure compared to 520 patients undergoing the Ravitch procedure. There was no significant difference found between the Nuss group versus Ravitch group in pediatric patients with regard to overall complications (OR =1.16; 95% CI: 0.61–2.19; I2=56%; P=0.65), reoperations (6.1% vs. 6.4%; OR =1.00; 95% CI: 0.40–2.50; I2=0%; P=1.00), wound infections (OR =0.58; 95% CI: 0.23–1.46; I2=0%; P=0.25), hemothorax (1.6% vs. 1.3%; OR =0.74; 95% CI: 0.21–2.65; I2=12%; P=0.64), pneumothorax (3.4% vs. 1.5%; OR =1.11; 95% CI: 0.42–2.93; I2=0%; P=0.83) or pneumonia (OR =0.15; 95% CI: 0.02–1.48; I2=0%; P=0.10). Adult patients undergoing the Nuss procedure had a higher incidence of overall complications (OR =3.26; 95% CI: 1.01–10.46; I2=0%; P=0.05), though there were far fewer studies that reported data. Conclusions These results suggest no difference between the Nuss and Ravitch procedures for pediatric patients, while in adults the Ravitch procedure resulted in fewer complications. PMID:27747174

  19. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of research proposals which have been approved under the procedure. (d) The department or agency head... research involving no more than minimal risk, and for minor changes in approved research. 690.110 Section... PROTECTION OF HUMAN SUBJECTS § 690.110 Expedited review procedures for certain kinds of research involving...

  20. 28 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of research proposals which have been approved under the procedure. (d) The department or agency head... kinds of research involving no more than minimal risk, and for minor changes in approved research. 46... SUBJECTS § 46.110 Expedited review procedures for certain kinds of research involving no more than...

  1. Do medical procedures in the arm increase the risk of lymphoedema after axillary surgery? A review.

    PubMed

    Cheng, Chris-Tin; Deitch, Jessica M; Haines, Ian E; Porter, David J; Kilbreath, Sharon L

    2014-01-01

    Lymphoedema of the arm is a potentially serious consequence of any axillary procedure performed during the management of breast cancer. In an attempt to reduce its incidence and severity, patients are instructed to avoid venepunctures and blood pressure measurements on the treated arm. These precautions are not possible in some patients and attempts to adhere to them can cause discomfort, anxiety and stress for both patients and their health-care workers. The strength with which these recommendations are made is in contrast to the level of evidence underpinning them. This paper reviews this evidence regarding the safety, or lack thereof, of blood pressure monitoring and intravenous puncture in women who have had axillary surgery. With this evidence generally being anecdotal in nature, there appears to be no rigorous evidence-based support for the risk-reduction behaviours of avoiding blood pressure monitoring and venepuncture in the affected arm in the prevention of lymphoedema after axillary procedure. A clinical trial was proposed to investigate whether such avoidance measures were valuable, but failed during its inception. There remains a need for research from prospective trials on this controversial topic to determine the most appropriate patient recommendations that should be provided after axillary procedure regarding the risks for development of lymphoedema.

  2. Review of edgematchimg procedures for digital cartographic data used in Geographic Information Systems (GIS)

    USGS Publications Warehouse

    Nebert, D.D.

    1989-01-01

    In the process of developing a continuous hydrographic data layer for water resources applications in the Pacific Northwest, map-edge discontinuities in the U.S. Geological Survey 1:100 ,000-scale digital data that required application of computer-assisted edgematching procedures were identified. The spatial data sets required by the project must have line features that match closely enough across map boundaries to ensure full line topology when adjacent files are joined by the computer. Automated edgematching techniques are evaluated as to their effects on positional accuracy. Interactive methods such as selective node-matching and on-screen editing are also reviewed. Interactive procedures complement automated methods by allowing supervision of edgematching in a cartographic and hydrologic context. Common edge conditions encountered in the preparation of the Northwest Rivers data base are described, as are recommended processing solutions. Suggested edgematching procedures for 1:100,000-scale hydrography data are included in an appendix to encourage consistent processing of this theme on a national scale. (USGS)

  3. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein

    PubMed Central

    Darwiche, Rabih; Kelleher, Alan; Hudspeth, Elissa M.; Schneiter, Roger; Asojo, Oluwatoyin A.

    2016-01-01

    The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and Pry2. Recombinant Pry1CAP forms dimers in solution, is sufficient for in vitro cholesterol binding, and has comparable binding properties as full-length Pry1. Two crystal structures of Pry1CAP are reported, one with Mg2+ coordinated to the conserved CAP tetrad (His208, Glu215, Glu233 and His250) in spacegroup I41 and the other without divalent cations in spacegroup P6122. The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one of which sits in the cholesterol binding site. Both structures reveal that the divalent cation and cholesterol binding sites are connected upon dimerization, providing a structural basis for the observed Mg2+-dependent sterol binding by Pry1. PMID:27344972

  4. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein

    NASA Astrophysics Data System (ADS)

    Darwiche, Rabih; Kelleher, Alan; Hudspeth, Elissa M.; Schneiter, Roger; Asojo, Oluwatoyin A.

    2016-06-01

    The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and Pry2. Recombinant Pry1CAP forms dimers in solution, is sufficient for in vitro cholesterol binding, and has comparable binding properties as full-length Pry1. Two crystal structures of Pry1CAP are reported, one with Mg2+ coordinated to the conserved CAP tetrad (His208, Glu215, Glu233 and His250) in spacegroup I41 and the other without divalent cations in spacegroup P6122. The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one of which sits in the cholesterol binding site. Both structures reveal that the divalent cation and cholesterol binding sites are connected upon dimerization, providing a structural basis for the observed Mg2+-dependent sterol binding by Pry1.

  5. Minor surgery procedures: A retrospective review and prospective survey in a pediatric population

    PubMed Central

    Chan, Emily; Bucevska, Marija; Verchere, Cynthia

    2015-01-01

    OBJECTIVE: The present study evaluated minor surgery procedures undertaken by a single plastic surgeon at BC Children’s Hospital (Vancouver, British Columbia) for patient and physician satisfaction, parent impressions, psychological concerns and complications. METHODS: Data were collected from a retrospective chart review and a prospective patient survey. Eligible subjects for the retrospective study included all pediatric patients undergoing minor surgery between May 2011 and April 2013. Parameters of interest included patient demographics, minor surgery specifics, complications and outcomes. Eligible subjects for the prospective patient survey included consecutive patients undergoing minor surgery between June 2013 and August 2013, as well as their parents. RESULTS: A total of 219 procedures were included in the retrospective review. The mean age of subjects was 13.1 years (range two weeks to 18 years). The median length of follow-up was 46 days (range four to 606 days). There were no major complications; however, 45 minor complications in 36 patients were found. Complications included crusting (4.6%), delayed wound healing (3.2%), hypersensitivity (2.3%), scar hypertrophy (1.8%), infection (0.9%) and other (7.8%). Outcomes were categorized as one of four outcomes: both satisfied (89.9%); patient satisfied but physician unsatisfied (0.8%); patient unsatisfied and physician satisfied (3.1%); and both unsatisfied (6.2%). In the prospective study, 32 subjects consented to participate in the survey. Of these subjects, 10 children and 12 parents responded to the questionnaires. Eighty-three percent of respondents indicated that their goals were accomplished by their procedure and that they would be willing to undergo minor surgery again. CONCLUSION: Minor surgery is possible and practical in pediatric plastic surgery clinics, with few complications and high patient and surgeon satisfaction. PMID:26361627

  6. Documentation of various approaches and outcomes in patients on warfarin undergoing dental procedures: a review article

    PubMed Central

    Shaer, Fayez El; Raslan, Ismael; Osaimi, Nora Al; Bawazeer, Ghada; Alayobi, Fhakr; Alhogbani, Tarek; Kharabsheh, Suliman; Habeeb, Walid Al

    2016-01-01

    Appropriate management of patients with mechanical prosthetic valves on warfarin during dental procedures is crucial. If the patients continue warfarin, they might develop bleeding, while interruption of therapy can cause thromboembolic events. Bridging therapy (mostly heparin) is used in some patients, while others stop medications. There is no unifying protocol. Information on management of patients on warfarin undergoing dental procedures in Saudi Arabia is lacking. Therefore, the current study aimed to provide more insight into various approaches utilized by clinicians to deal with such patients at a large teaching hospital in Riyadh, and to evaluate the frequency and severity of bleeding and thromboembolic complications during different types of dental procedures in this population. This was a cohort study. Patient records were used to collect data on peri-procedural management of patients on warfarin, continuation or interruption of warfarin therapy, as well as bleeding and thromboembolic complications. Fifty medical records were reviewed from March to October 2012. Regarding management, 10% had no proper documentation, 74% underwent bridging therapy, 12% discontinued warfarin therapy, and 4% continued warfarin. Of the patients, 31% had minor bleeding (15% in patients on bridging therapy and 16% in patients continuing warfarin). Thromboembolic complications were documented in 4%, (2% in those on bridging therapy and 2% in those discontinuing warfarin). Patients on bridging therapy (heparin) were admitted to the hospital for a mean of five days, and none of the other patients were admitted. Adopting the protocol to continue warfarin caused bleeding tendency that was controlled with the usual measures, with more cost effectiveness, and no thromboembolic risks. PMID:27679745

  7. Modern meta-heuristics based on nonlinear physics processes: A review of models and design procedures

    NASA Astrophysics Data System (ADS)

    Salcedo-Sanz, S.

    2016-10-01

    Meta-heuristic algorithms are problem-solving methods which try to find good-enough solutions to very hard optimization problems, at a reasonable computation time, where classical approaches fail, or cannot even been applied. Many existing meta-heuristics approaches are nature-inspired techniques, which work by simulating or modeling different natural processes in a computer. Historically, many of the most successful meta-heuristic approaches have had a biological inspiration, such as evolutionary computation or swarm intelligence paradigms, but in the last few years new approaches based on nonlinear physics processes modeling have been proposed and applied with success. Non-linear physics processes, modeled as optimization algorithms, are able to produce completely new search procedures, with extremely effective exploration capabilities in many cases, which are able to outperform existing optimization approaches. In this paper we review the most important optimization algorithms based on nonlinear physics, how they have been constructed from specific modeling of a real phenomena, and also their novelty in terms of comparison with alternative existing algorithms for optimization. We first review important concepts on optimization problems, search spaces and problems' difficulty. Then, the usefulness of heuristics and meta-heuristics approaches to face hard optimization problems is introduced, and some of the main existing classical versions of these algorithms are reviewed. The mathematical framework of different nonlinear physics processes is then introduced as a preparatory step to review in detail the most important meta-heuristics based on them. A discussion on the novelty of these approaches, their main computational implementation and design issues, and the evaluation of a novel meta-heuristic based on Strange Attractors mutation will be carried out to complete the review of these techniques. We also describe some of the most important application areas, in

  8. Diurnal and Directional Responses of Chlorophyll Fluorescence and the PRI in a Cornfield

    NASA Technical Reports Server (NTRS)

    Middleton, Elizabeth; Cheng, Y. B.; Corp, L.; Campbell, P.; Kustas, W.

    2010-01-01

    Determining the health and vigor of vegetation using high spectral resolution remote sensing is an important goal which has application to monitoring agriculture and ecosystem productivity and carbon exchange. Two spectral indices used to assess whether vegetation is performing near-optimally or exhibiting symptoms of environmental stress (e.g., drought or nutrient deficiency, non-optimal temperatures, etc.) are the Photochemical Reflectance Index (PRI) and solar-induced red and far-red Chlorophyll Fluorescence (Fs). Both the PRI and Fs capture the dynamics of photoprotection mechanisms within green foliage: the PRI is based on the association of the reflected radiation in the green spectrum with the xanthophyll cycle, whereas Fs measures the emitted radiation in the red and far-red spectrum. Fs was determined from retrievals in the atmospheric oxygen absorption features centered at 688 and 760 nm using a modified Fraunhofer Line Depth (FLD) method. We previously demonstrated diurnal and seasonal PRI differences for sunlit vs. shaded foliage in a conifer forest canopy, as expressed in the hotspot and darkspot of the Bidirectional Reflectance Function (BRF). In a USDA-ARS experimental field site located in Beltsville, MD, USA, measurements were acquired over a corn crop from a nadir view in 2008 with an ASD FieldSpec Pro (Analytical Spectral Devices, Inc., Boulder, CO, USA) to study the behavior of the PRI for sunlit and shaded foliage as captured in reflectance variations associated with the BRF, in a I m tall canopy in the vegetative growth stage. Those observations were compared to simulations obtained from two radiative transfer models. Measurements were then acquired to examine whether the PRI and Fs were influenced by view zenith and azimuth geometries at different times of day. Those measurements were made in 2010 with the Ocean Optics USB4000 Miniature Fiber Optic Spectrometer (Ocean Optics Inc., Dunedin, Florida, USA) at several times during the day on

  9. Photochemical Reflectance Index (PRI) and remote sensing of plant CO2 uptake

    NASA Astrophysics Data System (ADS)

    Penuelas, J.; Garbulsky, M. F.; Filella, I.

    2011-12-01

    An accurate continuous quantification of the role of terrestrial ecosystems as carbon sinks everywhere constitutes a key issue in the face of ongoing environmental disturbance and climate change. The emerging consistency of the relationship between Photochemical Reflectance Index (PRI) and light use efficiency at the leaf, canopy and ecosystem scales offers promising prospects for continuous global monitoring of plant primary productivity from space. We will present and discuss this consistency. This reflectance index is based on the short term reversible xanthophyll pigment changes accompanying plant stress. It also behaves as an index of the chlorophyll:carotenoid ratios and therefore of the photosynthetic activities associated with their changes with leaf development, aging or stress at longer term. At the leaf and canopy levels, the PRI has been extensively found adequate to estimate LUE and thus photosynthetic performance, i.e. gross primary productivity, and its use has been extended increasingly in the last few years both in natural and semi-natural vegetation and in crops. The results of these studies confirm an exponential relationship between LUE and PRI over a wide range of species and conditions, hence suggesting that the overall photosynthetic system is often sufficiently regulated to maintain consistent relationships between the pigment, morphological and physiological changes linked to PRI and the changes in CO2 fixation. In a further step forward, with the availability of the MODIS sensor on TERRA and AQUA satellites, PRI is now increasingly used also at the ecosystem scale. The results of our study comparing PRI data from MODIS and CO2 exchange data from eddy covariance towers show that there may even be a common exponential relationship for all of forests. The emerging consistency of the relationship between PRI, LUE and ecosystem CO2 uptake increasingly found in these studies suggests a surprising degree of "functional convergence" of biochemical

  10. A Meta-Analytic Review of the Cover-Copy-Compare and Variations of This Self-Management Procedure

    ERIC Educational Resources Information Center

    Joseph, Laurice M.; Konrad, Moira; Cates, Gary; Vajcner, Terra; Eveleigh, Elisha; Fishley, Katelyn M.

    2012-01-01

    Studies that examined copy-cover-compare (CCC) and variations of this procedure were reviewed and analyzed. This review revealed a substantial number of studies that validated the use of CCC across spelling and math skills and across students with and without disabilities. A meta-analysis of findings indicated that CCC and variations of this…

  11. 21 CFR 56.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... research involving no more than minimal risk, and for minor changes in approved research. 56.110 Section 56... of research involving no more than minimal risk, and for minor changes in approved research. (a) The... categories of research that may be reviewed by the IRB through an expedited review procedure. The list...

  12. Systematic Review: Predisposing, Precipitating, Perpetuating, and Present Factors Predicting Anticipatory Distress to Painful Medical Procedures in Children

    PubMed Central

    Pillai Riddell, Rebecca R.; Khan, Maria; Calic, Masa; Taddio, Anna; Tablon, Paula

    2016-01-01

    Objective To conduct a systematic review of the factors predicting anticipatory distress to painful medical procedures in children. Methods A systematic search was conducted to identify studies with factors related to anticipatory distress to painful medical procedures in children aged 0–18 years. The search retrieved 7,088 articles to review against inclusion criteria. A total of 77 studies were included in the review. Results 31 factors were found to predict anticipatory distress to painful medical procedures in children. A narrative synthesis of the evidence was conducted, and a summary figure is presented. Conclusions Many factors were elucidated that contribute to the occurrence of anticipatory distress to painful medical procedures. The factors that appear to increase anticipatory distress are child psychopathology, difficult child temperament, parent distress promoting behaviors, parent situational distress, previous pain events, parent anticipation of distress, and parent anxious predisposition. Longitudinal and experimental research is needed to further elucidate these factors. PMID:26338981

  13. Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs

    PubMed Central

    Szarzynska, Bogna; Sobkowiak, Lukasz; Pant, Bikram Datt; Balazadeh, Salma; Scheible, Wolf-Rüdiger; Mueller-Roeber, Bernd; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia

    2009-01-01

    Arabidopsis thaliana HYL1 is a nuclear double-stranded RNA-binding protein involved in the maturation of pri-miRNAs. A quantitative real-time PCR platform for parallel quantification of 176 pri-miRNAs was used to reveal strong accumulation of 57 miRNA precursors in the hyl1 mutant that completely lacks HYL1 protein. This approach enabled us for the first time to pinpoint particular members of MIRNA family genes that require HYL1 activity for efficient maturation of their precursors. Moreover, the accumulation of miRNA precursors in the hyl1 mutant gave us the opportunity to carry out 3′ and 5′ RACE experiments which revealed that some of these precursors are of unexpected length. The alignment of HYL1-dependent miRNA precursors to A. thaliana genomic sequences indicated the presence of introns in 12 out of 20 genes studied. Some of the characterized intron-containing pri-miRNAs undergo alternative splicing such as exon skipping or usage of alternative 5′ splice sites suggesting that this process plays a role in the regulation of miRNA biogenesis. In the hyl1 mutant intron-containing pri-miRNAs accumulate alongside spliced pri-miRNAs suggesting the recruitment of HYL1 into the miRNA precursor maturation pathway before their splicing occurs. PMID:19304749

  14. ALPPS Procedure for Extended Liver Resections: A Single Centre Experience and a Systematic Review

    PubMed Central

    Vivarelli, Marco; Vincenzi, Paolo; Montalti, Roberto; Fava, Giammarco; Tavio, Marcello; Coletta, Martina; Vecchi, Andrea; Nicolini, Daniele; Agostini, Andrea; Ali Ahmed, Emad; Giovagnoni, Andrea; Mocchegiani, Federico

    2015-01-01

    Aim To report a single-centre experience with the novel Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) technique and systematically review the related literature. Methods Since January 2013, patients with extended primary or secondary liver tumors whose future liver remnant (FLR) was considered too small to allow hepatic resection were prospectively assessed for the ALPPS procedure. A systematic literature search was performed using PubMed, Scopus and the Cochrane Library Central. Results Until July 2014 ALPPS was completed in 9 patients whose mean age was 60±8 years. Indications for surgical resection were metastases from colorectal cancer in 3 cases, perihilar cholangiocarcinoma in 3 cases, intrahepatic cholangiocarcinoma in 2 cases and hepatocellular carcinoma without chronic liver disease in 1 case. The calculated FLR volume was 289±122 mL (21.1±5.5%) before ALPPS-1 and 528±121 mL (32.2±5.7%) before ALLPS-2 (p<0.001). The increase in FLR between the two procedures was 96±47% (range: 24–160%, p<0.001). Additional interventions were performed in 4 cases: 3 patients underwent Roux-en-Y hepaticojejunostomy, and one case underwent wedge resection of a residual tumor in the FLR. The average time between the first and second step of the procedure was 10.8±2.9 days. The average hospital stay was 24.1±13.3 days. There was 1 postoperative death due to hepatic failure in the oldest patient of this series who had a perihilar cholangiocarcinoma and concomitant liver fibrosis; 11 complications occurred in 6 patients, 4 of whom had grade III or above disease. After a mean follow-up of 17.1±8.5 months, the overall survival was 89% at 3–6 and 12 months. The recurrence-free survival was 100%, 87.5% and 75% at 3-6-12 months respectively. The literature search yielded 148 articles, of which 22 articles published between 2012 and 2015 were included in this systematic review. Conclusion The ALPPS technique effectively increased the

  15. Non-Respiratory Indications for Polysomnography and Related Procedures in Children: An Evidence-Based Review

    PubMed Central

    Kotagal, Suresh; Nichols, Cynthia D.; Grigg-Damberger, Madeleine M.; Marcus, Carole L.; Witmans, Manisha B.; Kirk, Valerie G.; D'Andrea, Lynn A.; Hoban, Timothy F.

    2012-01-01

    Objective: This evidence-based review provides a systematic and comprehensive review of the literature regarding the utility of polysomnography for the evaluation of non-respiratory sleep disorders in children including hypersomnias, parasomnias, sleep-related movement disorders, and sleep in other special populations. Methods: A task force of pediatric sleep medicine experts performed a systematic review of the literature regarding the use of polysomnography for non-respiratory sleep disorders in children. They identified and graded 76 papers as evidence. Results: The main results include (1) polysomnography combined with the multiple sleep latency test is useful for evaluating disorders of excessive somnolence to objectively quantify sleepiness. The results have to be interpreted with consideration of the pubertal stage and regularity of the sleep patterns of the child; (2) polysomnography is indicated in children with parasomnias or sleep related movement disorders who have a high likelihood of having obstructive sleep apnea (OSA); (3) polysomnography is not routinely indicated in children with enuresis unless there is a high likelihood of OSA; (4) polysomnography can be helpful in evaluating children with restless legs syndrome (RLS) and when periodic limb movement disorder (PLMD) is suspected. Conclusions: These findings suggest that, in children with non-respiratory sleep disorders, polysomnography should be a part of a comprehensive sleep evaluation in selected circumstances to determine the nature of the events in more detail or when the suspicion of OSA is relatively high. Citation: Kotagal S; Nichols CD; Grigg-Damberger MM; Marcus CL; Witmans MB; Kirk VG; D'Andrea LA; Hoban TF. Non-respiratory indications for polysomnography and related procedures in children: an evidence-based review. SLEEP 2012;35(11):1451-1466. PMID:23115394

  16. Lung radiofrequency and microwave ablation: a review of indications, techniques and post-procedural imaging appearances.

    PubMed

    Smith, S L; Jennings, P E

    2015-02-01

    Lung ablation can be used to treat both primary and secondary thoracic malignancies. Evidence to support its use, particularly for metastases from colonic primary tumours, is now strong, with survival data in selected cases approaching that seen after surgery. Because of this, the use of ablative techniques (particularly thermal ablation) is growing and the Royal College of Radiologists predict that the number of patients who could benefit from such treatment may reach in excess of 5000 per year in the UK. Treatment is often limited to larger regional centres, and general radiologists often have limited awareness of the current indications and the techniques involved. Furthermore, radiologists without any prior experience are frequently expected to interpret post-treatment imaging, often performed in the context of acute complications, which have occurred after discharge. This review aims to provide an overview of the current indications for pulmonary ablation, together with the techniques involved and the range of post-procedural appearances.

  17. Lung radiofrequency and microwave ablation: a review of indications, techniques and post-procedural imaging appearances

    PubMed Central

    Jennings, P E

    2015-01-01

    Lung ablation can be used to treat both primary and secondary thoracic malignancies. Evidence to support its use, particularly for metastases from colonic primary tumours, is now strong, with survival data in selected cases approaching that seen after surgery. Because of this, the use of ablative techniques (particularly thermal ablation) is growing and the Royal College of Radiologists predict that the number of patients who could benefit from such treatment may reach in excess of 5000 per year in the UK. Treatment is often limited to larger regional centres, and general radiologists often have limited awareness of the current indications and the techniques involved. Furthermore, radiologists without any prior experience are frequently expected to interpret post-treatment imaging, often performed in the context of acute complications, which have occurred after discharge. This review aims to provide an overview of the current indications for pulmonary ablation, together with the techniques involved and the range of post-procedural appearances. PMID:25465192

  18. High-density polytetrafluoroethylene membranes in guided bone and tissue regeneration procedures: a literature review.

    PubMed

    Carbonell, J M; Martín, I Sanz; Santos, A; Pujol, A; Sanz-Moliner, J D; Nart, J

    2014-01-01

    Expanded polytetrafluoroethylene (e-PTFE) has been used successfully as a membrane barrier for regeneration procedures. However, when exposed to the oral cavity, its high porosity increases the risk of early infection, which can affect surgical outcomes. An alternative to e-PTFE is non-expanded and dense polytetrafluoroethylene (n-PFTE), which results in lower levels of early infection following surgical procedures. The aim of this literature review was to analyze and describe the available literature on n-PFTE, report the indications for use, advantages, disadvantages, surgical protocols, and complications. The medical databases Medline-PubMed and Cochrane Library were searched and supplemented with a hand search for reports published between 1980 and May 2012 on n-PTFE membranes. The search strategy was limited to animal, human, and in vitro studies in dental journals published in English. Twenty-four articles that analyzed the use of n-PTFE as a barrier membrane for guided tissue regeneration and guided bone regeneration around teeth and implants were identified: two in vitro studies, seven experimental studies, and 15 clinical studies. There is limited clinical and histological evidence for the use of n-PTFE membranes at present, with some indications in guided tissue regeneration and guided bone regeneration in immediate implants and fresh extraction sockets.

  19. Airway Management During Upper GI Endoscopic Procedures: State of the Art Review.

    PubMed

    Goudra, Basavana; Singh, Preet Mohinder

    2017-01-01

    With the growing popularity of propofol mediated deep sedation for upper gastrointestinal (GI) endoscopic procedures, challenges are being felt and appreciated. Research suggests that management of the airway is anything but routine in this setting. Although many studies and meta-analyses have demonstrated the safety of propofol sedation administered by registered nurses under the supervision of gastroenterologists (likely related to the lighter degrees of sedation than those provided by anesthesia providers and is under medicolegal controversy in the United States), there is no agreement on the optimum airway management for procedures such as endoscopic retrograde cholangiopancreatography. Failure to rescue an airway at an appropriate time has led to disastrous consequences. Inability to evaluate and appreciate the risk factors for aspiration can ruin the day for both the patient and the health care providers. This review apprises the reader of various aspects of airway management relevant to the practice of sedation during upper GI endoscopy. New devices and modification of existing devices are discussed in detail. Recognizing the fact that appropriate monitoring is important for timely recognition and management of potential airway disasters, these issues are explored thoroughly.

  20. Fluorescence, PRI and canopy temperature for water stress detection in cereal crops

    NASA Astrophysics Data System (ADS)

    Panigada, C.; Rossini, M.; Meroni, M.; Cilia, C.; Busetto, L.; Amaducci, S.; Boschetti, M.; Cogliati, S.; Picchi, V.; Pinto, F.; Marchesi, A.; Colombo, R.

    2014-08-01

    Narrow-band multispectral remote sensing techniques and thermal imagery were investigated for water stress detection in cereal crops. Visible and near infrared AISA Eagle (Specim, Finland) and thermal AHS-160 (Sensytech Inc., USA) imageries were acquired with an airborne survey on a farm-level experimental site where maize (Zea mays L.) and sorghum (Sorghum bicolor L.) were grown with three different irrigation treatments. Vegetation biophysical and eco-physiological measurements were collected concurrently with the airborne campaign. Leaf fluorescence yield (ΔF/Fm‧) resulted to be a good indirect measure of water stress. Therefore, ΔF/Fm‧ measurements were compared against remotely sensed indicators: (i) the Photochemical Reflectance Index (PRI), (ii) the sun-induced chlorophyll fluorescence at 760 nm (F760), retrieved by the Fraunhofer line depth method and (iii) the canopy temperature (TC) calculated decoupling soil and vegetation contributions. TC was related to ΔF/Fm‧ with the highest determination coefficient (R2 = 0.65), followed by PRI586 (reference band at 586 nm) (R2 = 0.51). The relationship with F760 was significant but weaker (R2 = 0.36). The coefficient of determination increased up to 0.54 when pigment concentration was considered by multiplying ΔF/Fm‧ and chlorophyll content, confirming the close relationship between passive fluorescence signal, pigment content and light photosystem efficiency. PRI586, F760 and TC maps were produced in maize and sorghum plots. The differences in the average values of PRI586, F760 and TC extracted from the plots with different water treatments showed that water treatments were well discriminated in maize plots by the three remotely sensed indicators. This was confirmed by the visual observation of the PRI586, F760 and TC maps, while in sorghum plots, F760 and TC appeared more sensitive to water stress compared to PRI586.

  1. Neuropathic Pain Post Spinal Cord Injury Part 2: Systematic Review of Dorsal Root Entry Zone Procedure

    PubMed Central

    2013-01-01

    Background: Pharmacotherapy may not sufficiently reduce neuropathic pain in many individuals post spinal cord injury (SCI). The use of alternative therapies such as surgery may be effective in reducing neuropathic pain in these individuals. However, because of the invasive nature of surgery, it is important to examine the evidence for use of this treatment. Objective: The purpose of this study was to conduct a systematic review of published literature on the surgical treatment of neuropathic pain after SCI. Methods: MEDLINE, CINAHL, EMBASE, and PsycINFO databases were searched for articles in which surgical treatment of pain after SCI was examined. Articles were restricted to the English language. Article selection was conducted by 2 independent reviewers with the following inclusion criteria: the subjects participated in a surgical intervention for neuropathic pain; at least 50% of the subjects had an SCI; at least 3 subjects had an SCI; and a definable intervention involving the dorsal root entry zone (DREZ) procedure was used to reduce pain. Data extracted included study design, study type, subject demographics, inclusion and exclusion criteria, sample size, outcome measures, and study results. Randomized controlled trials (RCTs) were assessed for quality using the Physiotherapy Evidence Database (PEDro) assessment scale. Levels of evidence were assigned to each intervention using a modified Sackett scale. Results: Eleven studies met the inclusion criteria. One study provided level 2 evidence, and the rest provided level 4 evidence. The DREZ procedure was shown to be more effective for segmental pain than for diffuse pain after SCI. Further, individuals with conus medullaris level injury were found to have a higher level of neuropathic pain relief than those with cervical, thoracic, or cauda equina injury. Conclusions: The studies demonstrated that the DREZ procedure may be effective in reducing segmental pain. Hence, DREZ may be important in treatment of

  2. The procedures used to review safety analysis reports for packagings submitted to the US Department of Energy for certification

    SciTech Connect

    Popper, G.F.; Raske, D.T.; Turula, P.

    1988-01-01

    This paper presents an overview of the procedures used at the Argonne National Laboratory (ANL) to review Safety Analysis Reports for Packagings (SARPs) submitted to the US Department of Energy (DOE) for issuance of a Certificate of Compliance. Prior to certification and shipment of a packaging for the transport of radioactive materials, a SARP must be prepared describing the design, contents, analyses, testing, and safety features of the packaging. The SARP must be reviewed to ensure that the specific packaging meets all DOE orders and federal regulations for safe transport. The ANL SARP review group provides an independent review and evaluation function for the DOE to ensure that the packaging meets all the prescribed requirements. This review involves many disciplines and includes evaluating the general information, drawings, construction details, operating procedures, maintenance and test programs, and the quality assurance plan for compliance with requirements. 14 refs., 6 figs.

  3. Intranasal ketamine for procedural sedation and analgesia in children: A systematic review

    PubMed Central

    2017-01-01

    Background Ketamine is commonly used for procedural sedation and analgesia (PSA) in children. Evidence suggests it can be administered intranasally (IN). We sought to review the evidence for IN ketamine for PSA in children. Methods We performed a systematic review of randomized trials of IN ketamine in PSA that reported any sedation-related outcome in children 0 to 19 years. Trials were identified through electronic searches of MEDLINE (1946–2016), EMBASE (1947–2016), Google Scholar (2016), CINAHL (1981–2016), The Cochrane Library (2016), Web of Science (2016), Scopus (2016), clinical trial registries, and conference proceedings (2000–2016) without language restrictions. The methodological qualities of studies and the overall quality of evidence were evaluated using the Cochrane Collaboration’s Risk of Bias tool, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, respectively. Results The review included 7 studies (n = 264) of children ranging from 0 to 14 years. Heterogeneity in study design precluded meta-analysis. Most studies were associated with a low or unclear risk of bias and outcome-specific ratings for quality of evidence were low or very low. In four of seven studies, IN ketamine provided superior sedation to comparators and resulted in adequate sedation for 148/175 (85%) of participants. Vomiting was the most common adverse effect; reported by 9/91 (10%) of participants. Conclusions IN ketamine administration is well tolerated and without serious adverse effects. Although most participants were deemed adequately sedated with IN ketamine, effectiveness of sedation with respect to superiority over comparators was inconsistent, precluding a recommendation for PSA in children. PMID:28319161

  4. A Proposal for a New Arteriovenous Malformation Grading Scale for Neuroendovascular Procedures and Literature Review

    PubMed Central

    Feliciano, Caleb E.; León-Berra, Ramón de; Hernandez-Gaitán, Manuel S.; Rodríguez-Mercado, Rafael

    2011-01-01

    Background Traditionally, decisions regarding treatment and outcomes for patients with cerebral arteriovenous malformations have made use of the Spetzler-Martin grading scale. The latter has withstood the test of time in clinical practice for AVM patients managed surgically and even when comparing studies involving other modalities of treatment. Recent awareness on the applicability of the grading system for risk assessment and outcome determination in cases of treatment by neuroendovascular means has emerged. We propose a similar grading system for neuroendovascular procedures based on a revision of the available literature. Methods A literature search using the keywords ‘arteriovenous malformation’, ‘embolization’ and ‘outcome’ was done. Articles studying the factors involved in complications and outcome determination for endovascular cerebral AVM patients were reviewed. These were tabulated and those dealing with anatomical, radiological and hemodynamic descriptions that were noted as significant determinants of risk or clinical outcome were used for development of a grading system. Results A grading system similar to the Spetzler-Martin grading scale was developed using factors deemed in the literature as significant determinants of outcome. The classification includes the number of feeding vessels into the AVM, the eloquence of adjacent areas, and the presence of fistulous components. Follow up studies are underway at our institution to validate our proposal. Yet, significant evidence exists in the literature validating those factors as stand alone determinants of outcome and risk, suggesting that this grading scale may well be applicable to endovascular embolization procedures. Conclusions A grading scale similar to the Spetzler-Martin grading system for use in risk assessment and outcome determination in brain AVM patients treated by endovascular means seems adequate and clinically feasible. Studies on applicability and validation are underway

  5. Heavy Metal and Trace Metal Analysis in Soil by Sequential Extraction: A Review of Procedures

    PubMed Central

    Zimmerman, Amanda Jo; Weindorf, David C.

    2010-01-01

    Quantification of heavy and trace metal contamination in soil can be arduous, requiring the use of lengthy and intricate extraction procedures which may or may not give reliable results. Of the many procedures in publication, some are designed to operate within specific parameters while others are designed for more broad application. Most procedures have been modified since their inception which creates ambiguity as to which procedure is most acceptable in a given situation. For this study, the Tessier, Community Bureau of Reference (BCR), Short, Galán, and Geological Society of Canada (GCS) procedures were examined to clarify benefits and limitations of each. Modifications of the Tessier, BCR, and GCS procedures were also examined. The efficacy of these procedures is addressed by looking at the soils used in each procedure, the limitations, applications, and future of sequential extraction. PMID:20414344

  6. Bilateral symmetry in vision and influence of ocular surgical procedures on binocular vision: A topical review.

    PubMed

    Arba Mosquera, Samuel; Verma, Shwetabh

    2016-01-01

    We analyze the role of bilateral symmetry in enhancing binocular visual ability in human eyes, and further explore how efficiently bilateral symmetry is preserved in different ocular surgical procedures. The inclusion criterion for this review was strict relevance to the clinical questions under research. Enantiomorphism has been reported in lower order aberrations, higher order aberrations and cone directionality. When contrast differs in the two eyes, binocular acuity is better than monocular acuity of the eye that receives higher contrast. Anisometropia has an uncommon occurrence in large populations. Anisometropia seen in infancy and childhood is transitory and of little consequence for the visual acuity. Binocular summation of contrast signals declines with age, independent of inter-ocular differences. The symmetric associations between the right and left eye could be explained by the symmetry in pupil offset and visual axis which is always nasal in both eyes. Binocular summation mitigates poor visual performance under low luminance conditions and strong inter-ocular disparity detrimentally affects binocular summation. Considerable symmetry of response exists in fellow eyes of patients undergoing myopic PRK and LASIK, however the method to determine whether or not symmetry is maintained consist of comparing individual terms in a variety of ad hoc ways both before and after the refractive surgery, ignoring the fact that retinal image quality for any individual is based on the sum of all terms. The analysis of bilateral symmetry should be related to the patients' binocular vision status. The role of aberrations in monocular and binocular vision needs further investigation.

  7. 22 CFR 225.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of research involving no more than minimal risk, and for minor changes in approved research. 225.110....110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. (a) The Secretary, HHS, has established, and published as...

  8. 15 CFR 27.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... certain kinds of research involving no more than minimal risk, and for minor changes in approved research... HUMAN SUBJECTS § 27.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. (a) The Secretary, HHS, has established,...

  9. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  10. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  11. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  12. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  13. 40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.110 Expedited review procedures for certain kinds of research involving no more than minimal... kinds of research involving no more than minimal risk, and for minor changes in approved research....

  14. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section...

  15. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... research involving no more than minimal risk, and for minor changes in approved research. 690.110 Section 690.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.110 Expedited review procedures for certain kinds of research involving...

  16. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures... available from the Office for Human Research Protections, HHS, or any successor office. (b) An IRB may use... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section...

  17. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures... available from the Office for Human Research Protections, HHS, or any successor office. (b) An IRB may use... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section...

  18. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures... available from the Office for Human Research Protections, HHS, or any successor office. (b) An IRB may use... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section...

  19. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures... available from the Office for Human Research Protections, HHS, or any successor office. (b) An IRB may use... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section...

  20. Interventions for Echolalic Behaviour for Children with Autism: A Review of Verbal Prompts and the Cues Pause Point Procedure.

    ERIC Educational Resources Information Center

    Kavon, Nicole M.; McLaughlin, T. F.

    1995-01-01

    This paper examines behavior interventions for echolalic behavior in children with autism, including verbal prompting (focusing on the echolalic behavior itself) and the cues-pause-point procedure (which employs the child's prerequisite skills to teach correct verbal responses). A review of the literature indicated that both techniques were…

  1. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  2. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  3. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  4. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  5. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  6. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION...

  7. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION...

  8. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION...

  9. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION...

  10. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION...

  11. 49 CFR 11.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... research involving no more than minimal risk, and for minor changes in approved research. 11.110 Section 11... Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. (a) The Secretary, HHS, has established, and published as a Notice in...

  12. 10 CFR 745.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... adopt a method for keeping all members advised of research proposals which have been approved under the... 10 Energy 4 2010-01-01 2010-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 745.110 Section...

  13. 21 CFR 601.25 - Review procedures to determine that licensed biological products are safe, effective, and not...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Review procedures to determine that licensed... conditions of use. 601.25 Section 601.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... provisions of the Federal Food, Drug, and Cosmetic Act is superseded to the extent that these...

  14. 26 CFR 301.7429-1 - Review of jeopardy and termination assessment and jeopardy levy procedures; information to taxpayer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Review of jeopardy and termination assessment... termination assessment and jeopardy levy procedures; information to taxpayer. Not later than 5 days after the day on which an assessment is made under section 6851(a), 6852(a), 6861(a), or 6862, or a levy is...

  15. 34 CFR 97.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Expedited review procedures for certain kinds of....110 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research...

  16. 34 CFR 222.95 - How are Indian policies and procedures reviewed to ensure compliance with the requirements in...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false How are Indian policies and procedures reviewed to ensure compliance with the requirements in section 8004(a) of the Act? 222.95 Section 222.95 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY...

  17. Prion-like Nanofibrils of Small Molecules (PriSM) Selectively Inhibit Cancer Cells by Impeding Cytoskeleton Dynamics*

    PubMed Central

    Kuang, Yi; Long, Marcus J. C.; Zhou, Jie; Shi, Junfeng; Gao, Yuan; Xu, Chen; Hedstrom, Lizbeth; Xu, Bing

    2014-01-01

    Emerging evidence reveals that prion-like structures play important roles to maintain the well-being of cells. Although self-assembly of small molecules also affords prion-like nanofibrils (PriSM), little is known about the functions and mechanisms of PriSM. Previous works demonstrated that PriSM formed by a dipeptide derivative selectively inhibiting the growth of glioblastoma cells over neuronal cells and effectively inhibiting xenograft tumor in animal models. Here we examine the protein targets, the internalization, and the cytotoxicity pathway of the PriSM. The results show that the PriSM selectively accumulate in cancer cells via macropinocytosis to impede the dynamics of cytoskeletal filaments via promiscuous interactions with cytoskeletal proteins, thus inducing apoptosis. Intriguingly, Tau proteins are able to alleviate the effect of the PriSM, thus protecting neuronal cells. This work illustrates PriSM as a new paradigm for developing polypharmacological agents that promiscuously interact with multiple proteins yet result in a primary phenotype, such as cancer inhibition PMID:25157102

  18. Association of a peptoid ligand with the apical loop of pri-miR-21 inhibits cleavage by Drosha

    PubMed Central

    Diaz, Jason P.; Chirayil, Rachel; Chirayil, Sara; Tom, Martin; Head, Katie J.; Luebke, Kevin J.

    2014-01-01

    We have found a small molecule that specifically inhibits cleavage of a precursor to the oncogenic miRNA, miR-21, by the microprocessor complex of Drosha and DGCR8. We identified novel ligands for the apical loop of this precursor from a screen of 14,024 N-substituted oligoglycines (peptoids) in a microarray format. Eight distinct compounds with specific affinity were obtained, three having affinities for the targeted loop in the low micromolar range and greater than 15-fold discrimination against a closely related hairpin. One of these compounds completely inhibits microprocessor cleavage of a miR-21 primary transcript at concentrations at which cleavage of another miRNA primary transcript, pri-miR-16, is little affected. The apical loop of pri-miR-21, placed in the context of pri-miR-16, is sufficient for inhibition of microprocessor cleavage by the peptoid. This compound also inhibits cleavage of pri-miR-21 containing the pri-miR-16 apical loop, suggesting an additional site of association within pri-miR-21. The reported peptoid is the first example of a small molecule that inhibits microprocessor cleavage by binding to the apical loop of a pri-miRNA. PMID:24497550

  19. Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.

    PubMed

    Kuang, Yi; Long, Marcus J C; Zhou, Jie; Shi, Junfeng; Gao, Yuan; Xu, Chen; Hedstrom, Lizbeth; Xu, Bing

    2014-10-17

    Emerging evidence reveals that prion-like structures play important roles to maintain the well-being of cells. Although self-assembly of small molecules also affords prion-like nanofibrils (PriSM), little is known about the functions and mechanisms of PriSM. Previous works demonstrated that PriSM formed by a dipeptide derivative selectively inhibiting the growth of glioblastoma cells over neuronal cells and effectively inhibiting xenograft tumor in animal models. Here we examine the protein targets, the internalization, and the cytotoxicity pathway of the PriSM. The results show that the PriSM selectively accumulate in cancer cells via macropinocytosis to impede the dynamics of cytoskeletal filaments via promiscuous interactions with cytoskeletal proteins, thus inducing apoptosis. Intriguingly, Tau proteins are able to alleviate the effect of the PriSM, thus protecting neuronal cells. This work illustrates PriSM as a new paradigm for developing polypharmacological agents that promiscuously interact with multiple proteins yet result in a primary phenotype, such as cancer inhibition.

  20. Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio

    SciTech Connect

    Liebschner, Dorothee; Brzezinski, Krzysztof; Dauter, Miroslawa; Dauter, Zbigniew; Nowak, Marta; Kur, Józef; Olszewski, Marcin

    2012-12-01

    The N-terminal domain of the PriB protein from the thermophilic bacterium T. tengcongensis (TtePriB) was expressed and its crystal structure has been solved at the atomic resolution of 1.09 Å by direct methods. PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the full 220-residue protein, adopts the characteristic oligonucleotide/oligosaccharide-binding (OB) structure consisting of a five-stranded β-barrel filled with hydrophobic residues and equipped with four loops extending from the barrel. In the crystal two protomers dimerize, forming a six-stranded antiparallel β-sheet. The structure of the N-terminal OB domain of T. tengcongensis shows significant differences compared with mesophile PriBs. While in all other known structures of PriB a dimer is formed by two identical OB domains in separate chains, TtePriB contains two consecutive OB domains in one chain. However, sequence comparison of both the N-terminal and the C-terminal domains of TtePriB suggests that they have analogous structures and that the natural protein possesses a structure similar to a dimer of two N-terminal domains.

  1. Antibiotic Prophylaxis for Gynecologic Procedures prior to and during the Utilization of Assisted Reproductive Technologies: A Systematic Review

    PubMed Central

    Hutchinson, Anne P.; Lekovich, Jovana P.; Hobeika, Elie; Elias, Rony T.

    2016-01-01

    The use of assisted reproductive technologies (ART) has increased steadily. There has been a corresponding increase in the number of ART-related procedures such as hysterosalpingography (HSG), saline infusion sonography (SIS), hysteroscopy, laparoscopy, oocyte retrieval, and embryo transfer (ET). While performing these procedures, the abdomen, upper vagina, and endocervix are breached, leading to the possibility of seeding pelvic structures with microorganisms. Antibiotic prophylaxis is therefore important to prevent or treat any procedure-related infections. After careful review of the published literature, it is evident that routine antibiotic prophylaxis is generally not recommended for the majority of ART-related procedures. For transcervical procedures such as HSG, SIS, hysteroscopy, ET, and chromotubation, patients at risk for pelvic infections should be screened and treated prior to the procedure. Patients with a history of pelvic inflammatory disease (PID) or dilated fallopian tubes are at high risk for postprocedural infections and should be given antibiotic prophylaxis during procedures such as HSG, SIS, or chromotubation. Antibiotic prophylaxis is recommended prior to oocyte retrieval in patients with a history of endometriosis, PID, ruptured appendicitis, or multiple prior pelvic surgeries. PMID:27047692

  2. Efficacy Outcome Measures for Procedural Sedation Clinical Trials in Adults: An ACTTION Systematic Review.

    PubMed

    Williams, Mark R; McKeown, Andrew; Dexter, Franklin; Miner, James R; Sessler, Daniel I; Vargo, John; Turk, Dennis C; Dworkin, Robert H

    2016-01-01

    Successful procedural sedation represents a spectrum of patient- and clinician-related goals. The absence of a gold-standard measure of the efficacy of procedural sedation has led to a variety of outcomes being used in clinical trials, with the consequent lack of consistency among measures, making comparisons among trials and meta-analyses challenging. We evaluated which existing measures have undergone psychometric analysis in a procedural sedation setting and whether the validity of any of these measures support their use across the range of procedures for which sedation is indicated. Numerous measures were found to have been used in clinical research on procedural sedation across a wide range of procedures. However, reliability and validity have been evaluated for only a limited number of sedation scales, observer-rated pain/discomfort scales, and satisfaction measures in only a few categories of procedures. Typically, studies only examined 1 or 2 aspects of scale validity. The results are likely unique to the specific clinical settings they were tested in. Certain scales, for example, those requiring motor stimulation, are unsuitable to evaluate sedation for procedures where movement is prohibited (e.g., magnetic resonance imaging scans). Further work is required to evaluate existing measures for procedures for which they were not developed. Depending on the outcomes of these efforts, it might ultimately be necessary to consider measures of sedation efficacy to be procedure specific.

  3. A systematic review on diagnostic procedures for specific language impairment: The sensitivity and specificity issues

    PubMed Central

    Shahmahmood, Toktam Maleki; Jalaie, Shohreh; Soleymani, Zahra; Haresabadi, Fatemeh; Nemati, Parvin

    2016-01-01

    Background: Identification of children with specific language impairment (SLI) has been viewed as both necessity and challenge. Investigators and clinicians use different tests and measures for this purpose. Some of these tests/measures have good psychometric properties, but it is not sufficient for diagnostic purposes. A diagnostic procedure can be used for identification a specific population with confidence only when its sensitivity and specificity are acceptable. In this study, we searched for tests/measures with predefined sensitivity and specificity for identification of preschool children with SLI from their typically developing peers. Materials and Methods: A computerized search in bibliographic databases from 2000 to August 2015 was performed with the following keywords: “specific language impairment” or SLI” and “primary language impairment” or ‘PLI’ with at least one of the followings: “diagnosis,” “identification,” “accuracy,” “sensitivity,” and “specificity.” In addition, the related citations and reference lists of the selected articles were considered. Results: The results of reviewing 23 included studies show that the index measures used in studies vary in accuracy with the sensitivity ranging from 16% to 100% and the specificity ranging from 14% to 100%. Conclusion: These varieties in sensitivity and specificity of different tests/measures confirm the necessity of attention to the diagnostic power of tests/measures before their use as diagnostic tool. Further, the results indicate there are some promising tests/measures that the available evidence supports their performances in the diagnosis of SLI in preschool-aged children, yet the place of a reference standard for the diagnosis of SLI is vacant among investigations. PMID:27904612

  4. Role of laser irradiation in direct pulp capping procedures: a systematic review and meta-analysis.

    PubMed

    Javed, Fawad; Kellesarian, Sergio Varela; Abduljabbar, Tariq; Gholamiazizi, Elham; Feng, Changyong; Aldosary, Khaled; Vohra, Fahim; Romanos, Georgios E

    2017-02-01

    A variety of materials are available to treat exposed dental pulp by direct pulp capping. The healing response of the pulp is crucial to form a dentin bridge and seal off the exposed pulp. Studies have used lasers to stimulate the exposed pulp to form tertiary dentin. The aim of the present systematic review and meta-analysis was to evaluate the evidence on the effects of laser irradiation as an adjunctive therapy to stimulate healing after pulp exposure. A systematic literature search was conducted up to April 2016. A structured search using the keywords "Direct pulp capping," "Lasers," "Calcium hydroxide pulp capping," and "Resin pulp capping" was performed. Initially, 34 potentially relevant articles were identified. After removal of duplicates and screening by title, abstract, and full text when necessary, nine studies were included. Studies were assessed for bias and data were synthetized using a random-effects meta-analysis model. Six studies were clinical, and three were preclinical animal trials; the follow-up period ranged from 2 weeks to 54 months. More than two thirds of the included studies showed that laser therapy used as an adjunct for direct pulp capping was more effective in maintaining pulp vitality than conventional therapy alone. Meta-analysis showed that the success rate in the laser treatment group was significantly higher than the control group (log odds ratio = 1.737; 95 % confidence interval, 1.304-2.171). Lasers treatment of exposed pulps can improve the outcome of direct pulp capping procedures; a number of confounding factors may have influenced the outcomes of the included studies.

  5. 42 CFR 433.120 - Procedures for reduction of FFP after reapproval review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Claims Processing and Information Retrieval Systems § 433.120 Procedures for reduction of FFP after... significance of the unsatisfactory conditions in overall mechanized claims processing and information...

  6. 76 FR 18571 - Notice of Submission of Proposed Information Collection to OMB; Environmental Review Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... Procedures for Entities Assuming HUD Environmental Responsibilities AGENCY: Office of the Chief Information... Assuming HUD Environmental Responsibilities. OMB Approval Number: 2506-0087. Form Numbers:...

  7. Entonox® inhalation to reduce pain in common diagnostic and therapeutic outpatient urological procedures: a review of the evidence

    PubMed Central

    Young, A; Ismail, M; Papatsoris, AG; Barua, JM; Calleary, JG; Masood, J

    2012-01-01

    INTRODUCTION Entonox® (50% nitrous oxide and 50% oxygen; BOC Healthcare, Manchester, UK) is an analgesic and anxiolytic agent that is used to successfully reduce pain and anxiety during dental, paediatric and emergency department procedures. In this article we review the application and efficacy of Entonox® in painful local anaesthesia urological procedures by performing a systematic review of the literature. METHODS A MEDLINE® search was performed using the terms ‘nitrous oxide’, ‘Entonox’, ‘prostate biopsy’, ‘flexible cystoscopy’ and ‘extracorporeal shock wave lithotripsy’. English language publications of randomised studies were identified and reviewed. RESULTS The search yielded five randomised studies that investigated the clinical efficacy of Entonox® as an analgesic for day case urological procedures. Three randomised controlled trials (RCTs) investigated Entonox® in transrectal ultrasonography guided prostate biopsy. All three reported significant reductions in pain score in the Entonox® versus control groups. One RCT reported significant reduction in pain during male flexible cystoscopy in the Entonox® group compared with the control group. One RCT, which examined the use of Entonox® during extracorporeal shock wave lithotripsy, found its use significantly decreased the pain score compared with the control group and this was comparable to intravenous pethidine. CONCLUSIONS Evidence from varied adult and paediatric procedures has shown Entonox® to be an effective, safe and patient acceptable form of analgesia. All published studies of its use in urological day case procedures have found it to significantly reduce procedural pain. There is huge potential to use this cheap, safe, effective analgesic in our current practice. PMID:22524905

  8. A Quantitative Review of Functional Analysis Procedures in Public School Settings

    ERIC Educational Resources Information Center

    Solnick, Mark D.; Ardoin, Scott P.

    2010-01-01

    Functional behavioral assessments can consist of indirect, descriptive and experimental procedures, such as a functional analysis. Although the research contains numerous examples demonstrating the effectiveness of functional analysis procedures, experimental conditions are often difficult to implement in classroom settings and analog conditions…

  9. 24 CFR 15.303 - Procedure for review of demands for production of material or provision of testimony in any legal...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Response to Demands in Legal Proceedings in Which the United States Is a Party § 15.303 Procedure for review of demands for production of material or provision of testimony in any legal proceeding in which... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Procedure for review of demands...

  10. Remote detection of water stress conditions via a diurnal photochemical reflectance index (PRI) improves yield prediction in rainfed wheat

    NASA Astrophysics Data System (ADS)

    Magney, T. S.; Vierling, L. A.; Eitel, J.

    2014-12-01

    Employing remotely sensed techniques to quantify the existence and magnitude of midday photosynthetic downregulation using the photochemical reflectance index (PRI) may reveal new information about plant responses to abiotic stressors in space and time. However, the interpretation and application of the PRI can be confounded because of its sensitivity to several variables changing at the diurnal (e.g., irradiation, shadow fraction) and seasonal (e.g., leaf area, chlorophyll and carotene pigment concentrations, irradiation) time scales. We explored different techniques to correct the PRI for variations in canopy structure and relative chlorophyll content (ChlR) using highly temporally resolved (frequency = five minutes) in-situ radiometric measurements of PRI and the Normalized Difference Vegetation Index (NDVI) over eight soft white spring wheat (Triticum aestivum L.)field plots under varying nitrogen and soil water conditions over two seasons. Our results suggest that the influence of seasonal variation in canopy ChlR and LAI on the diurnally measured PRI (PRIdiurnal) can be minimized using simple correction techniques, therefore improving the strength of PRI as a tool to quantify abiotic stressors such as daily changes in soil volumetric water content (SVWC), and vapor pressure deficit (VPD). PRIdiurnal responded strongly to available nitrogen, and linearly tracked seasonal changes in SVWC, VPD, and stomatal conductance (gc). Utilizing the PRI as an indicator of stress, yield predictions significantly over greenness indices such as the NDVI. This study provides insight towards the future interpretation and scaling of PRI to quantify rapid changes in photosynthesis, and as an indicator of plant stress.

  11. 5 CFR 1201.114 - Petition and cross petition for review-content and procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... petition for review, or a response to a petition for review, whether computer generated, typed, or... review is limited to 15 pages or 3750 words, whichever is less. Computer generated and typed pleadings... of OPM. The Director of OPM may intervene in a case before the Board under the standards stated in...

  12. 75 FR 52597 - Availability of Interim Procedures for Federal External Review and Model Notices Relating to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... Federal External Review and Model Notices Relating to Internal Claims and Appeals and External Review Under the Patient Protection and Affordable Care Act; Notice AGENCY: Internal Revenue Service... external review process and model notices both for internal claims and appeals and for external...

  13. Cognitive versus behavioral procedures in cognitive-behavior therapy: a critical review of the evidence.

    PubMed

    Latimer, P R; Sweet, A A

    1984-03-01

    During the past decade there has been an increasing emphasis on cognition in psychology and behavior therapy. This movement has spawned several distinctive cognitive therapies. While those therapies do employ innovative cognitive treatment procedures, they often do so in the context of well-established behavioral treatment procedures which may or may not be acknowledged by the label "cognitive-behavior therapy". This paper addresses the question of whether cognitive therapy is an evolutionary or revolutionary development from behavior therapy and critically evaluates the evidence for the efficacy of procedures specific to cognitive therapy.

  14. Complication Rates and Patency of Radiologically Guided Mushroom Gastrostomy, Balloon Gastrostomy, and Gastrojejunostomy: A Review of 250 Procedures

    SciTech Connect

    Yip, Doris; Vanasco, Matthew; Funaki, Brian

    2004-01-15

    To compare complication rates and tube performance of percutaneous mushroom gastrostomy, balloon gastrostomy, and gastrojejunostomy. Between September 9, 1999 and April 23, 2001, 203 patients underwent 250 radiologically guided percutaneous gastrostomy and gastrojejunostomy procedures. Follow-up was conducted through chart reviews and review of our interventional radiology database. Procedural and catheter-related complications were recorded. Chi-square statistical analysis was performed. In patients receiving mushroom-retained gastrostomy catheters (n = 114), the major complication rate was 0.88% (n = 1), the minor complication rate was 5.3% (n = 6), and the tube complication rate was 4.4% (n = 5). In patients receiving balloon-retained gastrostomy tubes (n = 67), the major complication rate was 0, the minor complication rate was 4.5% (n = 3), and the tube complication rate was 34.3% (n = 23). In patients receiving gastrojejunostomy catheters (n = 69), the major complication rate was 1.4% (n = 1), the minor complication rate was 2.9% (n = 2), and the tube complication rate was 34.8% (n = 24). No statistically significant differences were found between procedural or peri-procedural complications among the different types of tubes. Mushroom-retained catheters had significantly fewer tube complications (p < 0.01). Percutaneous gastrostomy and gastrojejunostomy have similar procedural and peri-procedural complication rates. Mushroom gastrostomy catheters have fewer tube-related complications compared with balloon gastrostomy and gastrojejunostomy catheters. In addition, mushroom-retained catheters exhibit the best overall long-term tube patency and are therefore the gastrostomy catheter of choice.

  15. Chest-wall thickness and percent thoracic fat estimation by B-mode ultrasound: system and procedure review

    SciTech Connect

    Berger, C.D.; Lane, B.H.; Dunsmore, M.R.

    1983-02-01

    Accurate measurement of chest wall thickness is necessary for estimation of lung burden of transuranic elements in humans. To achieve tis capability, the ORNL Whole Body Counter has acquired a B-mode ultrasonic imaging system for defining the structure within the thorax of the body. This report contains a review of the ultrasound system in use at the ORNL Whole Body Counter, including its theory of operation, and te procedure for use of the system. Future developmental plans are also presented.

  16. Recurrent anterior shoulder instability: a review of the Latarjet procedure and its postoperative rehabilitation.

    PubMed

    Fedorka, Catherine J; Mulcahey, Mary K

    2015-02-01

    The shoulder is the most common joint to dislocate in the human body, with the dislocation often occurring in the anterior direction. This injury frequently results in soft tissue injury (eg, labral tear, capsular stretching) or bone injury (eg, glenoid or humeral head bone loss), which commonly leads to persistent deficits of shoulder function and a high risk of subsequent instability episodes in young, active patients. Patients with a significant degree of glenoid bone loss (> 25%) may require surgical intervention using the Latarjet procedure, which is an open bony augmentation of the glenoid. This procedure involves transferring the tip of the coracoid to the anteroinferior glenoid, creating a bony block and musculotendinous sling to prevent instability. Rehabilitation after the procedure is a slow progression over 4 to 6 months to regain range of motion and strength, while protecting the bony augmentation. Recent reports have shown success with the Latarjet procedure, as indicated by patient satisfaction scores and a low rate of recurrent instability.

  17. The importance of a two-step impression procedure for complete denture fabrication: a systematic review of the literature.

    PubMed

    Regis, R R; Alves, C C S; Rocha, S S M; Negreiros, W A; Freitas-Pontes, K M

    2016-10-01

    The literature has questioned the real need for some clinical and laboratory procedures considered essential for achieving better results for complete denture fabrication. The aim of this study was to review the current literature concerning the relevance of a two-step impression procedure to achieve better clinical results in fabricating conventional complete dentures. Through an electronic search strategy of the PubMed/MEDLINE database, randomised controlled clinical trials which compared complete denture fabrication in adults in which one or two steps of impressions occurred were identified. The selections were made by three independent reviewers. Among the 540 titles initially identified, four studies (seven published papers) reporting on 257 patients evaluating aspects such as oral health-related quality of life, patient satisfaction with dentures in use, masticatory performance and chewing ability, denture quality, direct and indirect costs were considered eligible. The quality of included studies was assessed according to the Cochrane guidelines. The clinical studies considered for this review suggest that a two-step impression procedure may not be mandatory for the success of conventional complete denture fabrication regarding a variety of clinical aspects of denture quality and patients' perceptions of the treatment.

  18. The Combination Therapy of Dissolution Using Carbonated Liquid and Endoscopic Procedure for Bezoars: Pragmatical and Clinical Review

    PubMed Central

    Ogawa, Kohei; Mizuno, Ken-ichi; Shinagawa, Yoko; Kobayashi, Yuji; Abe, Hiroyuki; Watanabe, Yukari; Takahashi, Shunsaku; Hayashi, Kazunao; Yokoyama, Junji; Takeuchi, Manabu; Yamagiwa, Satoshi; Sato, Yuichi; Terai, Shuji

    2016-01-01

    Bezoars are relatively rare foreign bodies of gastrointestinal tract and often cause ileus and ulcerative lesions in the stomach and subsequent bleeding and perforation due to their size and stiffness. Therefore, the removal of bezoars is essential and recent development of devices, the endoscopic removal procedure, is often applied. However, due to their stiffness, simple endoscopic removal failed in not a few cases, and surgical removal has also been used. Recently, the efficacy of a combination therapy of endoscopic procedure and dissolution using carbonated liquid has been reported. To develop the safe and effective removal procedure, we carefully reviewed a total of 55 reported cases in this study including our 3 additional cases, successfully treated with dissolution with endoscopic fragmentation. In summary, the data showed the efficiency in the combination therapy, treating the larger size of bezoar and reducing the length of hospital stay. To the best of our knowledge, this is the largest pragmatical and clinical review for the combination therapy of dissolution and endoscopic treatment for bezoars. This review should help physicians to manage bezoars more efficiently. PMID:27642293

  19. Suprascapular nerve palsy after arthroscopic Latarjet procedure: a case report and review of literature.

    PubMed

    Sastre, Sergi; Peidro, Lluis; Méndez, Anna; Calvo, Emilio

    2016-02-01

    The Bristow and Latarjet procedures have become popular among orthopaedic surgeons thanks to the development of new instruments that allow the use of arthroscopic techniques to treat cases of glenohumeral instability with bone defects or capsular deficiency. Nonetheless, several complications have been reported after Latarjet procedures, including neurological injuries. This report describes surgical damage to the suprascapular nerve, an unusual complication. Level of evidence Expert opinion, Level V.

  20. The DAIR (debridement, antibiotics and implant retention) procedure for infected total knee replacement – a literature review

    PubMed Central

    Qasim, Sultan Naseer; Swann, Andrew; Ashford, Robert

    2017-01-01

    Prosthetic joint infection (PJI) is a devastating complication in total knee arthroplasty (TKA) and third most common cause of revision of TKA with significant morbidity and surgical challenges. Treatment options include non-operative measures with long term antibiotic suppression, debridement and implant retention (DAIR), one- or two-stage revision arthroplasty, arthrodesis and amputation. Implant retention without infection is ideal and DAIR has been reported to have variable success rates depending on patient factors, duration of infection, infecting micro-organisms, choice of procedure, single or multiple debridement procedures, arthroscopic or open, antibiotic choice and duration of antibiotic use. We present a thorough literature review of DAIR for infected TKA. The important factors contributing to failure are presence of sinus, immunocompromised patient, delay between onset of infection and debridement procedure, Staphylococcal infection in particular Meticillin Resistant Staphylococcal aureus, multiple debridement procedures, retention of exchangeable components and short antibiotic duration. In conclusion DAIR can be successful procedure to eradicate infection in TKA in selective patients with factors contributing to failure taken into account. PMID:28074774

  1. A review and survey of policies utilized for interventional pain procedures: a need for consensus

    PubMed Central

    Kohan, Lynn; Salajegheh, Reza; Hamill-Ruth, Robin J; Yerra, Sandeep; Butz, John

    2017-01-01

    Background Other than the newly published anticoagulation guidelines, there are currently few recommendations to assist pain medicine physicians in determining the safety parameters to follow when performing interventional pain procedures. Little information exists regarding policies for oral intake, cumulative steroid dose limits, driving restrictions with and without sedation, and routine medication use for interventional procedures. Methods A 16-question survey was developed on common policies currently in use for interventional pain procedures. The questionnaire was distributed through the American Society of Regional Anesthesia and Pain Medicine and American Academy of Pain Medicine. We sought to statistically analyze the range of policies being used by pain medicine physicians and to determine if there are any commonly accepted standards. Results A total of 337 physicians out of 4037 members responded to our survey with a response rate of 8.4%. A total of 82% of these respondents used a sedative agent while performing an interventional pain procedure. The majority of respondents required drivers after procedures, except after trigger points. A total of 47% indicated that they have an nil per os (NPO) policy for procedures without sedation. A total of 98% reported that they had an anticoagulation policy before an interventional procedure. A total of 17% indicated that the interval between steroid doses was <2 weeks, while 53% indicated that they waited 2–4 weeks between steroid doses. Conclusion Our study has clearly demonstrated a wide variation in the current practice among physicians regarding sedation, NPO status, steroid administration, and the need for designated drivers. There was much higher endorsement of policies regarding anticoagulation. There is an obvious need for evidence-based guidelines for these aspects of interventional pain care to improve patient safety and minimize the risk of adverse events. PMID:28360531

  2. 29 CFR 501.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE IMMIGRATION AND NATIONALITY ACT Administrative Proceedings Review of Administrative...

  3. 29 CFR 501.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE IMMIGRATION AND NATIONALITY ACT Administrative Proceedings Review of Administrative...

  4. 29 CFR 501.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE IMMIGRATION AND NATIONALITY ACT Administrative Proceedings Review of Administrative...

  5. 29 CFR 501.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE IMMIGRATION AND NATIONALITY ACT Administrative Proceedings Review of Administrative...

  6. 29 CFR 501.42 - Procedures for initiating and undertaking review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE IMMIGRATION AND NATIONALITY ACT Administrative Proceedings Review of Administrative...

  7. Regional anesthesia or patient-controlled analgesia and compartment syndrome in orthopedic surgical procedures: a systematic review

    PubMed Central

    Driscoll, Elizabeth BS; Maleki, Ana Hosseinzadeh; Jahromi, Leila; Hermecz, Brittany Nelson; Nelson, Lauren E; Vetter, Imelda L; Evenhuis, Spencer; Riesenberg, Lee Ann

    2016-01-01

    A systematic review of the literature on the use of regional anesthesia (RA) and patient-controlled analgesia (PCA) was conducted in patients who require orthopedic extremity procedures to determine whether either analgesic technique contributes to a delayed diagnosis of compartment syndrome (CS). A total of 34 relevant articles (28 case reports and six research articles) were identified. Of all case report articles published after 2009, the majority (75%) concluded that RA does not put the patient at an increased risk of a delayed diagnosis of CS. Of these, only two relevant prospective research studies focusing on RA or PCA and their relationship to CS were identified. Neither study resulted in any cases of CS. However, both had relatively small sample sizes. Given the lack of evidence identified in this systematic review, prospective studies or large-scale retrospective data reviews are needed to more strongly advocate the use of one modality of analgesia over the other in this patient population. PMID:27785097

  8. European Union centralised procedure for marketing authorisation of oncology drugs: an in-depth review of its efficiency.

    PubMed

    Netzer, Tilo

    2006-03-01

    In the European Union (EU) 20 anticancer agents have been successfully authorised via the Centralised Procedure since its implementation in 1995. Public information on these 20 agents has been reviewed in order to evaluate the effectiveness of the available regulatory mechanisms to facilitate the marketing authorisation of such drugs in the EU. These mechanisms include orphan drug legislation, exceptional circumstances provision and the accelerated evaluation procedure. Based on the fact that the EU orphan drug legislation was not implemented before the year 2000 no conclusions on its effectiveness to facilitate oncology drug development can be drawn today. Much more data are available on the effects of the exceptional circumstances provision, which was used in 6 out of 10 cases over the past four years. An analysis of the clinical data packages indicates that this provision allows authorisation of innovative oncology drugs based on smaller clinical data sets than required for full approval. The accelerated evaluation procedure was used in only one case and significantly reduced the scientific review time at the EU agencies. However, this mechanism does not influence the administrative time at the authorities, which accounted for almost one-third of the overall duration of the EU marketing authorisation procedures for oncology drugs. Revision of the EU drug legislation brings about some changes to the above-described provisions, with the potential for an improvement in the current situation. Thus, its implementation offers the chance to reduce the time that innovative oncology agents take to reach the market, although -- based on experience with the current procedures -- more effort is likely to be required to achieve this goal.

  9. Angulated implants: an alternative to bone augmentation and sinus lift procedure: systematic review.

    PubMed

    Asawa, Nikhil; Bulbule, Nilesh; Kakade, Dilip; Shah, Riddhi

    2015-03-01

    Rehabilitation of completely edentulous patients with implant becomes challenging due to reduced amount of bone available and pneumatisation of maxillary sinus or both. To successfully treat such patients, prior to implant placement, patient has to undergo invasive procedures like sinus lift and/or bone augmentation which is not possible many time due to many reasons. This article focuses on an alternative treatment procedure in which two posterior implants are placed at an angle and two anterior implants are placed axially thereby eliminating the need for sinus lift or bone augmentation procedures. This article broadly discusses this "All on Four" concept in all aspects, its effects on bone, prosthesis survival, forces acting etc along with various related studies.

  10. Angulated Implants: An Alternative to Bone Augmentation and Sinus Lift Procedure: Systematic Review

    PubMed Central

    Bulbule, Nilesh; Kakade, Dilip; Shah, Riddhi

    2015-01-01

    Rehabilitation of completely edentulous patients with implant becomes challenging due to reduced amount of bone available and pneumatisation of maxillary sinus or both. To successfully treat such patients, prior to implant placement, patient has to undergo invasive procedures like sinus lift and/or bone augmentation which is not possible many time due to many reasons. This article focuses on an alternative treatment procedure in which two posterior implants are placed at an angle and two anterior implants are placed axially thereby eliminating the need for sinus lift or bone augmentation procedures. This article broadly discusses this “All on Four” concept in all aspects, its effects on bone, prosthesis survival, forces acting etc along with various related studies. PMID:25954718

  11. 26 CFR 301.7429-2 - Review of jeopardy and termination assessment and jeopardy levy procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... date such assessment or levy is made. Such request shall be in writing, shall state fully the reasons... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Review of jeopardy and termination assessment... Proceedings Civil Actions by the United States § 301.7429-2 Review of jeopardy and termination assessment...

  12. Comparison of the Predictive Validity and Consistency among Preference Assessment Procedures: A Review of the Literature

    ERIC Educational Resources Information Center

    Kang, Soyeon; O'Reilly, Mark; Lancioni, Giulio; Falcomata, Terry S.; Sigafoos, Jeff; Xu, Ziwei

    2013-01-01

    We reviewed 14 experimental studies comparing different preference assessments for individuals with developmental disabilities that were published in peer-reviewed journals between 1985 and 2012. Studies were summarized based on the following six variables: (a) the number of participants, (b) the type of disability, (c) the number and type of…

  13. Review of Measurement Instruments and Procedures for Assessing Visual Behaviors: Implications for Quantitative Measurement.

    ERIC Educational Resources Information Center

    Janssen, Cynthia M.

    The assessment of vision as it relates to and interacts with motor development is reviewed. The focus is on eye readiness skills normally occuring in infants' first few months of life and preceding eye-hand coordination. These visual skills fall into three categories: fixation, tracking, and scanning. Six standardized scales are reviewed and…

  14. Evaluation of DSS-14 pedestal-review of top surface repair procedures

    NASA Technical Reports Server (NTRS)

    Oesterle, R. G.; Musser, D. W.; Salse, E. A. B.

    1983-01-01

    Proposed repair procedures for the top surface of the pedestal supporting the hydrostatic bearing runner for the 64m Antenna are presented. These procedures included: (1) removal of existing grout and concrete to approximately 8 in. below original concrete surface using a presplitting technique with expansive cement followed by secondary breaking; (2) preparation of exposed concrete surface including an epoxy bonding agent; and (3) replacement of material removed with 8 in. of new concrete surface including an epoxy bonding agent; and (4) replacement of material removed with 8 in. of new concrete and 4 in. of new grout.

  15. Long-Term Memory: A Review and Meta-Analysis of Studies of Declarative and Procedural Memory in Specific Language Impairment

    ERIC Educational Resources Information Center

    Lum, Jarrad A. G.; Conti-Ramsden, Gina

    2013-01-01

    This review examined the status of long-term memory systems in specific language impairment (SLI)--declarative memory and aspects of procedural memory in particular. Studies included in the review were identified following a systematic search of the literature and findings combined using meta-analysis. This review showed that individuals with SLI…

  16. 78 FR 38346 - Subcommittee on Procedures Review, Advisory Board on Radiation and Worker Health (ABRWH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ..., Participant Pass Code 9933701. Background: The ABRWH was established under the Energy Employees Occupational... Secretary, HHS, advising the Secretary on whether there is a class of employees at any Department of Energy... procedures: OTIB- 054 (``Fission and Activation Product Assignment for Internal Dose- Related Gross Beta...

  17. Review of CBP Interview Procedure and Data. Investigative Report No. 7321.

    ERIC Educational Resources Information Center

    Wood, Penelope

    After an interview procedure used with educable mentally retarded children is described, the findings of an examination of some collected interview data are reported in this study of the Computer Based Project for the Evaluation of Media for the Handicapped. An ex post facto analysis revealed a moderately high correlation between interviewer…

  18. 76 FR 26302 - Submission for OMB Review; Comment Request; Reunification Procedures for Unaccompanied Alien...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ...; Reunification Procedures for Unaccompanied Alien Children Description Following the passage of the 2002 Homeland... Resettlement (ORR), is charged with the care and placement of unaccompanied alien children in Federal custody... unaccompanied alien. Annual Burden Estimates Number of Average Instrument Number of responses per burden...

  19. Corralling Your Camp Horse Program: Reviewing Your Policies and Procedures and Creating a Written Manual.

    ERIC Educational Resources Information Center

    Glunt, Jim

    2000-01-01

    Camps offering horse programs need to have written policies and procedures to ensure quality control and risk minimization. Basic elements of a horse program manual include routine care of horses; general guidelines relating to participants, program, and staff; and emergency plans. Four information resources are presented. (TD)

  20. Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology.

    PubMed

    Zhou, Jie; Du, Xuewen; Xu, Bing

    2015-01-01

    Formed by non-covalent interactions and not defined at genetic level, the assemblies of small molecules in biology are complicated and less explored. A common morphology of the supramolecular assemblies of small molecules is nanofibrils, which coincidentally resembles the nanofibrils formed by proteins such as prions. So these supramolecular assemblies are termed as prion-like nanofibrils of small molecules (PriSM). Emerging evidence from several unrelated fields over the past decade implies the significance of PriSM in biology and medicine. This perspective aims to highlight some recent advances of the research on PriSM. This paper starts with description of the intriguing similarities between PriSM and prions, discusses the paradoxical features of PriSM, introduces the methods for elucidating the biological functions of PriSM, illustrates several examples of beneficial aspects of PriSM, and finishes with the promises and current challenges in the research of PriSM. We anticipate that the research of PriSM will contribute to the fundamental understanding at the intersection of supramolecular chemistry and cell biology and ultimately lead to a new paradigm of molecular (or supramolecular) therapeutics for biomedicine.

  1. 78 FR 45198 - Federal Acquisition Regulation; Submission for OMB Review; Anti-Kickback Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... agency collecting the information. Response: In accordance with the Paperwork Reduction Act (PRA... a FAR clause that provides a benefit to the public and the agency collecting the information... reviewing instructions; using technology to collect, process, and disclose information; adjusting...

  2. 78 FR 30733 - Modernizing Federal Infrastructure Review and Permitting Regulations, Policies, and Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... best-management practices. These best-management practices include: integrating project reviews among... best-management practices, and by making additional improvements to enhance efficiencies in the... memorandum, the Steering Committee shall identify and prioritize opportunities to modernize key...

  3. A literature review of record linkage procedures focusing on infant health outcomes.

    PubMed

    Machado, Carla Jorge

    2004-01-01

    Record linkage is a powerful tool in assembling information from different data sources and has been used by a number of public health researchers. In this review, we provide an overview of the record linkage methodologies, focusing particularly on probabilistic record linkage. We then stress the purposes and research applications of linking records by focusing on studies of infant health outcomes based on large data sets, and provide a critical review of the studies in Brazil.

  4. Computer-Based Procedure Systems: Technical Basis and Human Factors Review Guidance

    DTIC Science & Technology

    2000-03-01

    controlling the plant. Historically, plant procedures have been paper-based and were not considered part of the HSI. Following the accident at Three Mile...Manuals Interfacing systems loss-of-coolant accident Knowledge-based system Loss-of-coolant accident Light water reactor xxi NUREG/CR-6634...have been paper-based and were not considered part of the HSI. Following the accident at the Three Mile Island NPP, the nuclear power industry

  5. Incidence of adverse events in paediatric procedural sedation in the emergency department: a systematic review and meta-analysis

    PubMed Central

    Bellolio, M Fernanda; Puls, Henrique A; Anderson, Jana L; Gilani, Waqas I; Murad, M Hassan; Barrionuevo, Patricia; Erwin, Patricia J; Wang, Zhen; Hess, Erik P

    2016-01-01

    Objective and design We conducted a systematic review and meta-analysis to evaluate the incidence of adverse events in the emergency department (ED) during procedural sedation in the paediatric population. Randomised controlled trials and observational studies from the past 10 years were included. We adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Setting ED. Participants Children. Interventions Procedural sedation. Outcomes Adverse events like vomiting, agitation, hypoxia and apnoea. Meta-analysis was performed with random-effects model and reported as incidence rates with 95% CIs. Results A total of 1177 studies were retrieved for screening and 258 were selected for full-text review. 41 studies reporting on 13 883 procedural sedations in 13 876 children (≤18 years) were included. The most common adverse events (all reported per 1000 sedations) were: vomiting 55.5 (CI 45.2 to 65.8), agitation 17.9 (CI 12.2 to 23.7), hypoxia 14.8 (CI 10.2 to 19.3) and apnoea 7.1 (CI 3.2 to 11.0). The need to intervene with either bag valve mask, oral airway or positive pressure ventilation occurred in 5.0 per 1000 sedations (CI 2.3 to 7.6). The incidences of severe respiratory events were: 34 cases of laryngospasm among 8687 sedations (2.9 per 1000 sedations, CI 1.1 to 4.7; absolute rate 3.9 per 1000 sedations), 4 intubations among 9136 sedations and 0 cases of aspiration among 3326 sedations. 33 of the 34 cases of laryngospasm occurred in patients who received ketamine. Conclusions Serious adverse respiratory events are very rare in paediatric procedural sedation in the ED. Emesis and agitation are the most frequent adverse events. Hypoxia, a late indicator of respiratory depression, occurs in 1.5% of sedations. Laryngospasm, though rare, happens most frequently with ketamine. The results of this study provide quantitative risk estimates to facilitate shared decision-making, risk communication, informed consent and

  6. An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase.

    PubMed

    Windgassen, Tricia A; Keck, James L

    2016-11-16

    Helicases couple ATP hydrolysis to nucleic acid binding and unwinding via molecular mechanisms that remain poorly defined for most enzyme subfamilies within the superfamily 2 (SF2) helicase group. A crystal structure of the PriA SF2 DNA helicase, which governs restart of prematurely terminated replication processes in bacteria, revealed the presence of an aromatic-rich loop (ARL) on the presumptive DNA-binding surface of the enzyme. The position and sequence of the ARL was similar to loops known to couple ATP hydrolysis with DNA binding in a subset of other SF2 enzymes, however, the roles of the ARL in PriA had not been investigated. Here, we show that changes within the ARL sequence uncouple PriA ATPase activity from DNA binding. In vitro protein-DNA crosslinking experiments define a residue- and nucleotide-specific interaction map for PriA, showing that the ARL binds replication fork junctions whereas other sites bind the leading or lagging strands. We propose that DNA binding to the ARL allosterically triggers ATP hydrolysis in PriA. Additional SF2 helicases with similarly positioned loops may also couple DNA binding to ATP hydrolysis using related mechanisms.

  7. The crystal structure of Neisseria gonorrhoeae PriB reveals mechanistic differences among bacterial DNA replication restart pathways

    SciTech Connect

    Dong, Jinlan; George, Nicholas P.; Duckett, Katrina L.; DeBeer, Madeleine A.P.; Lopper, Matthew E.

    2010-05-25

    Reactivation of repaired DNA replication forks is essential for complete duplication of bacterial genomes. However, not all bacteria encode homologs of the well-studied Escherichia coli DNA replication restart primosome proteins, suggesting that there might be distinct mechanistic differences among DNA replication restart pathways in diverse bacteria. Since reactivation of repaired DNA replication forks requires coordinated DNA and protein binding by DNA replication restart primosome proteins, we determined the crystal structure of Neisseria gonorrhoeae PriB at 2.7 {angstrom} resolution and investigated its ability to physically interact with DNA and PriA helicase. Comparison of the crystal structures of PriB from N. gonorrhoeae and E. coli reveals a well-conserved homodimeric structure consisting of two oligosaccharide/oligonucleotide-binding (OB) folds. In spite of their overall structural similarity, there is significant species variation in the type and distribution of surface amino acid residues. This correlates with striking differences in the affinity with which each PriB homolog binds single-stranded DNA and PriA helicase. These results provide evidence that mechanisms of DNA replication restart are not identical across diverse species and that these pathways have likely become specialized to meet the needs of individual organisms.

  8. An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase

    PubMed Central

    Windgassen, Tricia A.; Keck, James L.

    2016-01-01

    Helicases couple ATP hydrolysis to nucleic acid binding and unwinding via molecular mechanisms that remain poorly defined for most enzyme subfamilies within the superfamily 2 (SF2) helicase group. A crystal structure of the PriA SF2 DNA helicase, which governs restart of prematurely terminated replication processes in bacteria, revealed the presence of an aromatic-rich loop (ARL) on the presumptive DNA-binding surface of the enzyme. The position and sequence of the ARL was similar to loops known to couple ATP hydrolysis with DNA binding in a subset of other SF2 enzymes, however, the roles of the ARL in PriA had not been investigated. Here, we show that changes within the ARL sequence uncouple PriA ATPase activity from DNA binding. In vitro protein-DNA crosslinking experiments define a residue- and nucleotide-specific interaction map for PriA, showing that the ARL binds replication fork junctions whereas other sites bind the leading or lagging strands. We propose that DNA binding to the ARL allosterically triggers ATP hydrolysis in PriA. Additional SF2 helicases with similarly positioned loops may also couple DNA binding to ATP hydrolysis using related mechanisms. PMID:27484483

  9. A review of 105 consecutive uniport endoscopic plantar fascial release procedures for the treatment of chronic plantar fasciitis.

    PubMed

    Morton, Troy N; Zimmerman, Jeffrey P; Lee, Michael; Schaber, John D

    2013-01-01

    Plantar fasciitis is a common cause of heel pain in the U.S. Army soldier, resulting in a significant loss of man hours. Given the heavy operations tempo of the U.S. military, successful treatment options need to be considered and used as quickly as possible. Plantar fasciitis can be successfully treated in up to 90% of patients using conservative measures. Operative intervention might need to be considered for those in whom conservative measures have failed. The present report is a review of 105 consecutive uniport endoscopic plantar fascial release procedures performed by the principal investigator during a 9-year period. The following data were collected and analyzed: gender, age, weight, height, body mass index, medical treatment facility, procedure laterality, preoperative pain levels, postoperative pain levels at 3 months, first ambulatory day in the controlled ankle motion boot, return to activity as tolerated, and complications. Three major points were of interest: evidence of improvement in chronic plantar fasciitis when treated with uniport endoscopic procedures; the patient attributes associated with self-reported pain levels 90 days postoperatively; and the patient attributes associated with the average time until patients were able to return to activities as tolerated in a controlled ankle motion boot. It was noted that 44.5% of those with a body mass index of 29.80 kg/m(2) or greater reported a postoperative pain level of 0; and 96.3% of those with a body mass index of 25.53 kg/m(2) or less reported postoperative pain levels of 0. The analyzed data were used to characterize the clinical outcomes of the procedure, identify changes in outcome with surgeon experience, and identify whether certain patient subgroups have better outcomes, allowing surgeons to identify which patient might be the best candidates for an endoscopic release procedure.

  10. Response to the independent technical review of the UMTRA Project procedures and practices for well drilling and development

    SciTech Connect

    Not Available

    1994-07-01

    This report is a response to the findings and recommendations contained in the ITR report. The text of this document summarizes each ITR finding and recommendation, presents the TAC response, and concludes that implementation of many of the recommendations would benefit the UMTRA Project. Implementation of the recommendations represents ongoing improvement to the TAC well installation and development procedures and will result, in lower overall project costs. Appendix B is an implementation plan that groups similar or complementary action items, provides a schedule for implementation, identifies the group or people responsible for the changes, and estimates hours to implement the changes. The four major action items are as follows: (1) ITR Reevaluation, (2) Well Installation SOP Review and Revision, (3) Well Installation Contract Review and Revision, and (4) TAC and DOE Communications Improvement. The hours listed to implement the improvements are intended to be estimates for budgeting and planning purposes for the remainder of this fiscal year and the upcoming fiscal year.

  11. Review of inference procedures for the interclass correlation coefficient with emphasis on applications to family studies.

    PubMed

    Donner, A; Eliasziw, M; Shoukri, M

    1998-01-01

    Recent theory and methodology for inferences concerning the interclass correlation coefficient are reviewed, focusing on the case of a single individual in one class and a variable number of individuals in the other. Topics discussed include point and interval estimation, as well as significance-testing, with emphasis on application to data arising from family studies.

  12. Review of Measurement Instruments and Procedures for Assessing Mobility Behaviors: Implications for Quantitative Measurement.

    ERIC Educational Resources Information Center

    Lehr, Donna H.

    The literature review identifies information regarding the emergence of mobility skills in infants and young handicapped children, including rolling, crawling, creeping, and walking. Sections discuss the following topics: assessment instruments relevant to mobility, the identification of developmental milestones in mobility, and a hierarchy of the…

  13. 76 FR 31225 - Procedures Governing Administrative Review of a United States Trustee's Decision To Deny a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... certain expenses are actual and necessary for the administration of bankruptcy cases. The Bankruptcy Abuse... ensures that the process for administratively reviewing a United States Trustee's denial of a trustee's... period of time and obtains court approval of this plan. This process is termed confirming a chapter 12...

  14. 15 CFR 923.133 - Procedure for conducting continuing reviews of approved State CZM programs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... performance of coastal States with respect to coastal management. Each review shall include a written evaluation with an assessment and detailed findings concerning the extent to which the State has implemented... purpose of implementing and enforcing its approved CZM program. (2) For the purpose of evaluation,...

  15. A Review of Research on Procedures for Teaching Safety Skills to Persons with Developmental Disabilities

    ERIC Educational Resources Information Center

    Dixon, Dennis R.; Bergstrom, Ryan; Smith, Marlena N.; Tarbox, Jonathan

    2010-01-01

    Safety skills are an important but often neglected area of training for persons with developmental disabilities (DD). The present study reviewed the literature on teaching safety skills to persons with DD. Safety skills involve a variety of behaviors such as knowing how to cross the street or what to do in case of a house fire. A number of studies…

  16. 49 CFR 8.19 - Procedures for submitting and processing requests for classification reviews.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... classification review involves material produced by or under the cognizance of the U.S. Coast Guard or the Federal Aviation Administration, the Director will forward the request to the headquarters security staff of the element concerned for action. If the request involves material produced by other...

  17. OECHC Program Review Guide. A Manual of Standard Operating Procedures. Revised.

    ERIC Educational Resources Information Center

    New York State Education Dept. Albany. Office for the Education of Children with Handicapping Conditions.

    The program review guide provides a framework and a source of reference for the monitoring staff of the New York State Education Department's Office for Education of Children with Handicapping Conditions. The manual simultaneously provides a means for school districts, the Boards of Cooperative Educational Services, and other agencies to monitor…

  18. STS-55 SL-D2 crew reviews preflight CEIT procedures in KSC conference room

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Spacelab Deutsche 2 (SL-D2) crewmembers, seated at a conference table, discuss Crew Equipment Interface Test (CEIT) procedures in a briefing room at the Kennedy Space Center (KSC). From left are Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross, German Payload Specialist 1 Ulrich Walter, Pilot Terence T. Henricks, Commander Steven R. Nagel, MS3 Bernard J. Harris, Jr, German Payload Specialist 2 Hans Schlegel, and MS2 Charles J. Precourt. Seated in the foreground are KSC technicians and payload integration officers. Walter and Schlegel are representatives from DLR. View provided by KSC with alternate KSC number KSC-93PC-212.

  19. Review of the design and manufacturing procedures for large-format holographic optical elements

    NASA Astrophysics Data System (ADS)

    Stojanoff, Christo G.; Schuette, Hartmut; Schulat, Jochen; Froning, Philipp

    1998-10-01

    The objective of this research program was the development of the technology for the industrial manufacturing of HOEs for technical applications such as: holographic solar concentrators for utilization in photovoltaic energy conversion and solar photochemistry, and integrated holographic stacks for daylighting, glazing and shading in buildings. Some of the fabricated HOEs exhibit apertures in the order of 8 square meters. The accomplished technology facilitates the continuous fabrication of the holographic films on glass or plastic substrata. The standard holographic material we use for the fabrication of HOEs is dichromated gelatin (DCG) on glass or plastic film (PET) substrata. The dichromated gelatin layer could be prepared with different compositions to accommodate the desired exposures and chemical processing procedures. At present we manufacture holographic plates on glass substrata in sizes of up to 1 meter square. The holographic film on plastic substratum is 20 cm wide and could be made in lengths of hundredths of meters. The inexpensive fabrication of such large formats is attained by automation of the entire process: film manufacturing, hologram copying, development and test. We present in this paper the design considerations and the developed manufacturing procedures. These comprise the fabrication of large format reflective holograms for concentrating mirrors and the copying of transmissive holograms, such as gratings and lenses, using in-plane contact copying in checkerboard arrangement or rotating drum continuous copying onto an endless plastic film.

  20. Nephrolithiasis after bariatric surgery: A review of pathophysiologic mechanisms and procedural risk.

    PubMed

    Bhatti, Umer Hasan; Duffy, Andrew J; Roberts, Kurt Eric; Shariff, Amir Hafeez

    2016-12-01

    Obesity alone is a known risk factor for nephrolithiasis, and bariatric surgery has been linked to a higher incidence of post-operative new-onset nephrolithiasis. The mean interval from bariatric surgery to diagnosis of nephrolithiasis, ranges from 1.5 to 3.6 years. The stone risk is greatest for purely malabsorptive procedures, intermediate for Roux-en-Y gastric bypass and lowest for purely restrictive procedures (laparoscopic adjustable gastric banding, laparoscopic sleeve gastrectomy) where it approaches or is reduced below that of non-operative obese controls. A history of nephrolithiasis and increasing age at the time of surgery are both associated with an increased risk of new stone formation post-operatively. The underlying pathophysiologic changes following bariatric surgery include increased colonic absorption of oxalate leading to hyperoxaluria, hypocitraturia and increased urinary calcium oxalate supersaturation, which predispose to stone formation. The majority of incident stones are medically managed, with some requiring interventions in the form of lithotripsy or ureteroscopy.

  1. Reliability of procedures used in the physical examination of non-specific low back pain: a systematic review.

    PubMed

    May, Stephen; Littlewood, Chris; Bishop, Annette

    2006-01-01

    The purpose of this systematic review was to determine the quality of the research and to assess the reliability of different types of physical examination procedures used in the assessment of patients with non-specific low back pain. A search of electronic databases (MEDLINE, PEDro, AMED, EMBASE, Cochrane, and CINAHL) up to August 2005 identified 48 relevant studies which were analysed for quality and reliability. Pre-established criteria were used to judge the quality of the studies and satisfactory reliability, and conclusions emphasised high quality studies (> or = 60% methods score). The mean quality score of the studies was 52% (range 0 to 88%), indicating weak to moderate methodology. Based on the upper threshold used (kappa/ICC > 0.85) most procedures demonstrated either conflicting evidence or moderate to strong evidence of low reliability. When the lower threshold was used (kappa/ICC > 0.70) evidence about pain response to repeated movements changed from contradictory to moderate evidence for high reliability. Most procedures commonly used by clinicians in the examination of patients with back pain demonstrate low reliability.

  2. The perioperative dental screening and management of patients undergoing cardiothoracic, vascular surgery and other cardiovascular invasive procedures: A systematic review.

    PubMed

    Cotti, Elisabetta; Arrica, Mariantonietta; Di Lenarda, Andrea; Serri, Sara B; Bassareo, Pierpaolo; Padeletti, Luigi; Mercuro, Giuseppe

    2017-03-01

    Background One controversial issue in the relationship between oral care and cardiovascular diseases is how and whether to manage oral infections prior to cardiovascular surgery or other cardiovascular invasive procedures. Design We designed a systematic review to assess the information available on three main questions. Is there an agreement on the need for dental evaluation and treatment before cardiovascular interventions? Are consistent clinical recommendations or protocols available? Is dental treatment prior to cardiovascular interventions effective? Methods A systematic electronic search of MEDLINE, Scopus and Web of Science was performed from the database inceptions up to 31 April 2016. Searches were performed using Boolean operators to combine medical subject headings and free text words. Because this review included a large, heterogeneous group of study designs and sources, the results were synthesised in a narrative approach. Results In total, 2447 studies were identified: 2099 (+241 duplicates) were excluded after screening; 107 were included for full-text assessment; 55 were excluded for not meeting the inclusion criteria; and 11 were not available. Thus, 44 studies meeting the inclusion criteria were analysed. We found that, for patients undergoing cardiovascular surgery, there is a general agreement on the need for screening and treatment of dental infections, but not on the protocols. We also found that there are conflicting indications on when and to what extent to perform the treatment and that the risk-to-benefit ratios for these treatments are controversial. Conclusion No satisfactory answers regarding dental care before cardiovascular invasive procedures are available.

  3. Could laparoscopic colon and rectal surgery become the standard of care? A review and experience with 750 procedures

    PubMed Central

    Schlachta, Christopher M.; Mamazza, Joseph; Gregoire, Roger; Burpee, Stephen E.; Poulin, Eric C.

    2003-01-01

    Introduction The benefits of the laparoscopic approach to colon and rectal surgery do not seem as great as for other laparoscopic procedures. To study this further we decided to review the current literature and the 10-year experience of a surgical group from university teaching hospitals in Montréal, Québec and Toronto in performing laparoscopic colon and rectal surgery. Methods The prospectively designed case series comprised all patients having laparoscopic colon and rectal surgery. The procedures were carried out by a group of 4 surgeons between April 1991 and November 2001. We noted intraoperative complications, any conversions to open surgery, operating time, postoperative complications and postoperative length of hospital stay. Results The group attempted 750 laparoscopic colon and rectal procedures of which 669 were completed laparoscopically. Malignant disease was the indication for surgery in 49.6% of cases. Right hemicolectomy and sigmoid colectomy accounted for 54.5% of procedures performed. Intraoperative complications occurred in 8.3%, with 29.0% of these resulting in conversion to open surgery. The overall rate of conversion to open surgery was 10.8%, most commonly for oncologic concerns. Median operating time was 175 minutes for all procedures. Postoperative complications occurred in 27.5% of procedures completed laparoscopically but were mostly minor wound complications. Pulmonary complications occurred in only 1.0%. The anastomotic leak rate was 2.5%. The early reoperation rate was 2.4%. Postoperative mortality was 2.2%. No port site metastases have yet been detected. The median postoperative length of stay was 5 days. Conclusions The clinical outcomes of laparoscopic colon and rectal surgery in this 10-year experience are consistent with numerous cohort studies and randomized clinical trials. Laparoscopic colon and rectal surgery in the hands of well-trained surgeons can be performed safely with short hospital stay, low analgesic requirements

  4. Reviewing Consensus HFE Standards for NRC Use: A Case Study using the IEEE Standard for Computerized Operating Procedure Systems

    SciTech Connect

    OHara, J.M.; Higgins, J.; Xing, J., Fleger S. - NRC

    2010-11-07

    The U.S. Nuclear Regulatory Commission’s (NRC’s) endorsement of consensus standards provides a cost-effective means of enhancing the staff’s ability to review state-of-the-art designs. Although the NRC endorsed consensus standards in many technical disciplines, it yet has to do so in human factors engineering (HFE). The purpose of our study was to develop a standardized methodology whereby to evaluate a consensus HFE standard to determine its appropriateness to, and adequacy for using in licensing reviews. The high-level objective of the methodology is to ensure that the guidance meets the NRC’s requirements on scientific- and engineering-rigor that they use in developing their own guidance. We propose four criteria for endorsing a consensus standard: (1) It should meet an existing need for NRC’s licensing and safety reviews; (2) it should be based on sound HFE principles; (3) it should be thoroughly peer-reviewed; and, (4) it should address human performance issues identified in the literature. Our methodology offers a means to assess these four criteria. We used it to evaluate an Institute of Electrical and Electronics Engineers’ (IEEE) draft standard on computerized operating procedure systems. We concluded that the IEEE standard generally met the established criteria, although several areas were identified that needed further clarification. Our evaluation methodology particularly was useful for identifying issues to be resolved, and for providing a basis for judging whether the staff should consider endorsing the standard. The methodology also helped recognize criteria in the proposed standard that may benefit from additional scrutiny by the staff. The evaluation methodology developed is applicable generally to reviewing other HFE standards that the NRC is considering for use or endorsement.

  5. Regional anesthesia for pediatric knee surgery: a review of the indications, procedures, outcomes, safety, and challenges

    PubMed Central

    Muhly, Wallis T; Gurnaney, Harshad G; Ganesh, Arjunan

    2015-01-01

    The indications for surgery on the knee in children and adolescents share some similarity to adult practice in that there are an increasing number of sports-related injuries requiring surgical repair. In addition, there are some unique age-related conditions or congenital abnormalities that may present as indications for orthopedic intervention at the level of the knee. The efficacy and safety of peripheral nerve blocks (PNBs) for postoperative analgesia following orthopedic surgery has been well established in adults. Recent studies have also demonstrated earlier functional recovery after surgery in patients who received PNBs. In children, PNB is gaining popularity, and increasing data are emerging to demonstrate the feasibility, efficacy, and safety in this population. In this paper, we will review some of the most common indications for surgery involving the knee in children and the anatomy of knee, associated dermatomal and osteotomal innervation, and the PNBs most commonly used to produce analgesia at the level of the knee. We will review the evidence in support of regional anesthesia in children in terms of both the quality conferred to the immediate postoperative care and the role of continuous PNBs in maintaining effective analgesia following discharge. Also we will discuss some of the subtle challenges in utilizing regional anesthesia in the pediatric patient including the use of general anesthesia when performing regional anesthesia and the issue of monitoring for compartment syndrome. Finally, we will offer some thoughts about areas of practice that are in need of further investigation. PMID:26609245

  6. Improving outcomes using German Inpatient Quality Indicators in conjunction with peer review procedures.

    PubMed

    Mansky, Thomas; Völzke, Tatjana; Nimptsch, Ulrike

    2015-01-01

    Some hospital comparisons seem to generate confusion because different methods of outcome comparisons lead to different results in hospital rankings. This article questions the concept of overall comparisons of hospitals, which are multiproduct enterprises and may have specialties that provide good results in some areas despite having worse outcomes in others. Therefore, the authors argue for a disease specific view of outcome measurement. The concept of the German Inpatient Quality Indicators is explained. These indicators cover volume, mortality, and other information by a disease specific approach, which includes information for potential patients as well as specific feedback to the physicians responsible for the respective specialty. This article focuses on the feedback to the hospitals and explains how these indicators can be used for improvement in conjunction with a peer review process. The indicators provide information to the hospitals regarding their relative position because German reference values are available for all indicators. Thus, the indicators can serve as a trigger instrument for identifying possible quality problems. Based on these indications, peer review can be used to analyze the treatment processes and to eventually verify weaknesses and define actions for improvement. The first studies indicate that the use of this approach within hospital quality management can largely improve hospital outcomes in hospitals with subpar results compared to the German average.

  7. Totally laparoscopic total gastrectomy for gastric cancer: literature review and comparison of the procedure of esophagojejunostomy.

    PubMed

    Umemura, Akira; Koeda, Keisuke; Sasaki, Akira; Fujiwara, Hisataka; Kimura, Yusuke; Iwaya, Takeshi; Akiyama, Yuji; Wakabayashi, Go

    2015-04-01

    There has been a recent increase in the use of totally laparoscopic total gastrectomy (TLTG) for gastric cancer. However, there is no scientific evidence to determine which esophagojejunostomy (EJS) technique is the best. In addition, both short- and long-term oncological results of TLTG are inconsistent. We reviewed 25 articles about TLTG for gastric cancer in which at least 10 cases were included. We analyzed the short-term results, relationships between EJS techniques and complications, long-term oncological results, and comparative study results of TLTG. TLTG was performed in a total of 1170 patients. The mortality rate was 0.7%, and the short-term results were satisfactory. Regarding EJS techniques and complications, circular staplers (CSs) methods were significantly associated with leakage (4.7% vs. 1.1%, p < 0.001) and stenosis (8.3% vs. 1.8%, p < 0.001) of the EJS as compared with the linear stapler method. The long-term oncological prognosis was acceptable in patients with early gastric cancers and without metastases to lymph nodes. Although TLTG tended to increase surgical time compared with open total gastrectomy and laparoscopy-assisted total gastrectomy, it reduced intraoperative blood loss and was expected to shorten postoperative hospital stay. TLTG is found to be safer and more feasible than open total gastrectomy and laparoscopy-assisted total gastrectomy. At present, there is no evidence to encourage performing TLTG for patients with advanced gastric cancer from the viewpoint of long-term oncological prognosis. Although the current major EJS techniques are CS and linear stapler methods, in this review, CS methods are significantly associated with leakage and stenosis of the EJS.

  8. Explaining the variability of the photochemical reflectance index (PRI) at the canopy-scale: Disentangling the effects of phenological and physiological changes.

    PubMed

    Merlier, Elodie; Hmimina, Gabriel; Dufrêne, Eric; Soudani, Kamel

    2015-10-01

    Assessing photosynthesis rates at the ecosystem scale and over large regions is important for tracking the global carbon cycle and remote sensing has provided new and useful approaches for performing this assessment. The photochemical reflectance index (PRI) is a good estimator of short-term light-use efficiency (LUE) at the leaf scale; however, confounding factors appear at larger temporal and spatial scales. In this study, canopy-scale PRI variability was investigated for three species (Fagus sylvatica L., Quercus robur L. and Pinus sylvestris L.) growing under contrasting soil moisture conditions. Throughout the growing season, no significant differences in chlorophyll content and in violaxanthin, antheraxanthin and zeaxanthin were found between species or treatments. The daily PRI vs PAR (photosynthetically active radiation) relationships were determined using continuous measurements obtained at high frequency throughout the entire growing season, from early spring budburst to later autumn senescence, and were used to deconvolute the physiological PRI variability related to LUE variations due to phenological variability and related to temporal changes in the biochemical and structural canopy attributes. The PRI vs PAR relationship is used to show that the canopy-scale PRI measured at low radiation depends on the chlorophyll content of the canopy. The range of PRI variations at an intra-daily scale and the dynamics of the xanthophyll pool do not vary between days, which suggests that the PRI responds to a xanthophyll ratio. The PAR values at PRI saturation are mainly related to the canopy chlorophyll content during budburst and senescence and to the soil moisture content when the chlorophyll content is no longer a limiting factor. This parameter is significantly lower in the oak species that experience less stress from variations in soil moisture and is species dependant. These results provide new insights regarding the analysis and the meaning of PRI

  9. Critical review on the Environmental Risk Assessment of medicinal products for human use in the centralised procedure.

    PubMed

    Caneva, Laura; Bonelli, Milton; Papaluca-Amati, Marisa; Vidal, Jean-Marc

    2014-04-01

    In this article we analyse the Environmental Risk Assessment (ERA) of 59 medicinal products for human use authorised in the EU through the centralised procedure between 2011 and 2012, to establish whether company submissions are compliant with the European Medicines Agency (EMA) guideline and complete in terms of data and study reports provided. The most frequent questions raised by EU regulatory authorities are described, together with an evaluation of the presence and quality of ERA-related information in published regulatory assessment documents. The results of this review show recent improvement in ERA-related data presented in regulatory assessment documents available to the public while also highlighting a need to develop further guidance on environmental issues in order to assist applicants improve their ERA dossiers and overcome current shortcomings.

  10. The efficacy of eutectic mixture of local anesthetics as a topical anesthetic agent used for dental procedures: A brief review.

    PubMed

    Daneshkazemi, Alireza; Abrisham, Seyyed Mohammad; Daneshkazemi, Pedram; Davoudi, Amin

    2016-01-01

    Dental pain management is one of the most critical aspects of modern dentistry which might affect patient's quality of life. Several methods are suggested to provide a painless situation for patients. Desensitization of the oral site using topical anesthetics is one of those methods. The improvements of topical anesthetic agents are probably one of the most important advances in dental science in the past 100 years. Most of them are safe and can be applied on oral mucosa with minimal irritation and allergic reactions. At present, these agents are various with different potent and indications. Eutectic mixture of local anesthetics (EMLA) (lidocaine + prilocaine) is a commercial anesthetic agent which has got acceptance among dental clinicians. This article provides a brief review about the efficacy of EMLA as a topical anesthetic agent when used during dental procedures.

  11. The efficacy of eutectic mixture of local anesthetics as a topical anesthetic agent used for dental procedures: A brief review

    PubMed Central

    Daneshkazemi, Alireza; Abrisham, Seyyed Mohammad; Daneshkazemi, Pedram; Davoudi, Amin

    2016-01-01

    Dental pain management is one of the most critical aspects of modern dentistry which might affect patient's quality of life. Several methods are suggested to provide a painless situation for patients. Desensitization of the oral site using topical anesthetics is one of those methods. The improvements of topical anesthetic agents are probably one of the most important advances in dental science in the past 100 years. Most of them are safe and can be applied on oral mucosa with minimal irritation and allergic reactions. At present, these agents are various with different potent and indications. Eutectic mixture of local anesthetics (EMLA) (lidocaine + prilocaine) is a commercial anesthetic agent which has got acceptance among dental clinicians. This article provides a brief review about the efficacy of EMLA as a topical anesthetic agent when used during dental procedures. PMID:27746520

  12. A review of combined experimental and computational procedures for assessing biopolymer structure–process–property relationships

    PubMed Central

    Gronau, Greta; Krishnaji, Sreevidhya T.; Kinahan, Michelle E.; Giesa, Tristan; Wong, Joyce Y.; Kaplan, David L.; Buehler, Markus J.

    2013-01-01

    Tailored biomaterials with tunable functional properties are desirable for many applications ranging from drug delivery to regenerative medicine. To improve the predictability of biopolymer materials functionality, multiple design parameters need to be considered, along with appropriate models. In this article we review the state of the art of synthesis and processing related to the design of biopolymers, with an emphasis on the integration of bottom-up computational modeling in the design process. We consider three prominent examples of well-studied biopolymer materials – elastin, silk, and collagen – and assess their hierarchical structure, intriguing functional properties and categorize existing approaches to study these materials. We find that an integrated design approach in which both experiments and computational modeling are used has rarely been applied for these materials due to difficulties in relating insights gained on different length- and time-scales. In this context, multiscale engineering offers a powerful means to accelerate the biomaterials design process for the development of tailored materials that suit the needs posed by the various applications. The combined use of experimental and computational tools has a very broad applicability not only in the field of biopolymers, but can be exploited to tailor the properties of other polymers and composite materials in general. PMID:22938765

  13. Anatomical resection of hepatocellular carcinoma: A critical review of the procedure and its benefits on survival

    PubMed Central

    Kang, Koo Jeong; Ahn, Keun Soo

    2017-01-01

    Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the third most frequent cause of cancer-related death. Advances in preoperative assessment of HCC (e.g., imaging studies and liver function tests), surgical techniques, and postoperative care have improved the surgical outcomes and survival of patients who undergo hepatic resection for HCC. However, in the last 20 years, the long-term survival after hepatectomy has remained unsatisfactory owing to the high rates of local recurrence and multicentric occurrence. Anatomical liver resection (AR) was introduced in the 1980s. Although several studies have revealed tangible benefits of AR for HCC, these benefits are still debated. Because most HCCs occur in patients with liver cirrhosis and poor hepatic function, there are many factors that affect survival, including the surgical method. Nevertheless, many studies have documented the perioperative and long-term benefits of AR in various conditions. In this article, we review the results of several recently published, well-designed comparative studies of AR, to investigate whether AR provides real benefits on survival outcomes. We also discuss the potential pitfalls associated with this approach. PMID:28275294

  14. Nonvital tooth bleaching: a review of the literature and clinical procedures.

    PubMed

    Plotino, Gianluca; Buono, Laura; Grande, Nicola M; Pameijer, Cornelis H; Somma, Francesco

    2008-04-01

    Tooth discoloration varies in etiology, appearance, localization, severity, and adhesion to tooth structure. It can be defined as being extrinsic or intrinsic on the basis of localization and etiology. In this review of the literature, various causes of tooth discoloration, different bleaching materials, and their applications to endodontically treated teeth have been described. In the walking bleach technique the root filling should be completed first, and a cervical seal must be established. The bleaching agent should be changed every 3-7 days. The thermocatalytic technique involves placement of a bleaching agent in the pulp chamber followed by heat application. At the end of each visit the bleaching agent is left in the tooth so that it can function as a walking bleach until the next visit. External bleaching of endodontically treated teeth with an in-office technique requires a high concentration gel. It might be a supplement to the walking bleach technique, if the results are not satisfactory after 3-4 visits. These treatments require a bonded temporary filling or a bonded resin composite to seal the access cavity. There is a deficiency of evidence-based science in the literature that addresses the prognosis of bleached nonvital teeth. Therefore, it is important to always be aware of the possible complications and risks that are associated with the different bleaching techniques.

  15. Road-corridor planning in the EIA procedure in Spain. A review of case studies

    SciTech Connect

    Loro, Manuel [Department of Urban and Regional Planning and Environment, Civil Engineering School, Universidad Politécnica de Madrid, Prof. Aranguren s Transport Research Centre Universidad Politécnica de Madrid, ETSI Caminos, Canales y Puertos, Prof. Aranguren s Centro de investigación del transporte, TRANSyT-UPM, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, Prof. Aranguren s Arce, Rosa M. [Department of Urban and Regional Planning and Environment, Civil Engineering School, Universidad Politécnica de Madrid, Prof. Aranguren s Transport Research Centre Universidad Politécnica de Madrid, ETSI Caminos, Canales y Puertos, Prof. Aranguren s Centro de investigación del transporte, TRANSyT-UPM, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, Prof. Aranguren s Ortega, Emilio [Transport Research Centre Universidad Politécnica de Madrid, ETSI Caminos, Canales y Puertos, Prof. Aranguren s Centro de investigación del transporte, TRANSyT-UPM, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, Prof. Aranguren s Department of Construction and Rural Roads, Forestry Engineering School, Universidad Politécnica de Madrid, Ciudad Universitaria s and others

    2014-01-15

    The assessment of different alternatives in road-corridor planning must be based on a number of well-defined territorial variables that serve as decision making criteria, and this requires a high-quality preliminary environmental assessment study. In Spain the formal specifications for the technical requirements stipulate the constraints that must be considered in the early stages of defining road corridors, but not how they should be analyzed and ranked. As part of the feasibility study of a new road definition, the most common methodology is to establish different levels of Territorial Carrying Capacity (TCC) in the study area in order to summarize the territorial variables on thematic maps and to ease the tracing process of road-corridor layout alternatives. This paper explores the variables used in 22 road-construction projects conducted by the Ministry of Public Works that were subject to the Spanish EIA regulation and published between 2006 and 2008. The aim was to evaluate the quality of the methods applied and the homogeneity and suitability of the variables used for defining the TCC. The variables were clustered into physical, environmental, land-use and cultural constraints for the purpose of comparing the TCC values assigned in the studies reviewed. We found the average quality of the studies to be generally acceptable in terms of the justification of the methodology, the weighting and classification of the variables, and the creation of a synthesis map. Nevertheless, the methods for assessing the TCC are not sufficiently standardized; there is a lack of uniformity in the cartographic information sources and methodologies for the TCC valuation. -- Highlights: • We explore 22 road-corridor planning studies subjected to the Spanish EIA regulation. • We analyze the variables selected for defining territorial carrying capacity. • The quality of the studies is acceptable (methodology, variable weighting, mapping). • There is heterogeneity in the

  16. Quantitative radiomics studies for tissue characterization: a review of technology and methodological procedures.

    PubMed

    Larue, Ruben T H M; Defraene, Gilles; De Ruysscher, Dirk; Lambin, Philippe; van Elmpt, Wouter

    2017-02-01

    Quantitative analysis of tumour characteristics based on medical imaging is an emerging field of research. In recent years, quantitative imaging features derived from CT, positron emission tomography and MR scans were shown to be of added value in the prediction of outcome parameters in oncology, in what is called the radiomics field. However, results might be difficult to compare owing to a lack of standardized methodologies to conduct quantitative image analyses. In this review, we aim to present an overview of the current challenges, technical routines and protocols that are involved in quantitative imaging studies. The first issue that should be overcome is the dependency of several features on the scan acquisition and image reconstruction parameters. Adopting consistent methods in the subsequent target segmentation step is evenly crucial. To further establish robust quantitative image analyses, standardization or at least calibration of imaging features based on different feature extraction settings is required, especially for texture- and filter-based features. Several open-source and commercial software packages to perform feature extraction are currently available, all with slightly different functionalities, which makes benchmarking quite challenging. The number of imaging features calculated is typically larger than the number of patients studied, which emphasizes the importance of proper feature selection and prediction model-building routines to prevent overfitting. Even though many of these challenges still need to be addressed before quantitative imaging can be brought into daily clinical practice, radiomics is expected to be a critical component for the integration of image-derived information to personalize treatment in the future.

  17. Remote sensing of plant emissions of volatile isoprenoids with PRI. Prospects for upscaling (Invited)

    NASA Astrophysics Data System (ADS)

    Penuelas, J.

    2013-12-01

    Josep Peñuelas*1,2, Giovanni Marino1,2,3,4, Joan LLusia1,2, Catherine Morfopoulos1,2,5, Gerard Farre-Armengol1,2, Shawn Kefauver, Alex Guenther6 , Francesca Rapparini7 , Roger Seco1,2,6, Marc Estiarte1,2, Mónica Mejia-Chang1,2, Romà Ogaya1,2, Jordi Sardans1,2 , Andrew Turnipseed6, Peter Harley6, Osvaldo Facini7, Rita Baraldi7, Jim Greenberg6 , Iolanda Filella1,2 1 CSIC, Global Ecology Unit CREAF-CEAB-UAB, Cerdanyola del Vallés 08193, Catalonia, Spain 2 CREAF, Cerdanyola del Vallés 08193, Catalonia, Spain 3 Dipartimento di Bioscienze e Territorio, Università degli Studi del Molise, Contrada Fonte Lappone, 86090 Pesche (IS), Italy 4 Institute for Plant Protection, National Research Council, Via Madonna del Piano 10, 50019 Sesto Fiorentino (FI), Italy 5 Division of Ecology and Evolution, Imperial College, Silwood Park, Ascot, SL5 7PY, UK 6 Atmospheric Chemistry Division, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000, USA 7 Biometeorology Institute, IBIMET-CNR, Via P. Gobetti 101, Bologna, Italy Abstract Terrestrial plants re-emit around 1-2% of the carbon they fix as isoprene and monoterpenes. These emissions play major roles in the ecological relationships among living organisms and in atmospheric chemistry and climate, and yet their actual quantification at the ecosystem level in different regions is far from being resolved. Phenomenological models are used to estimate the emission rates, but the limited understanding of the function and regulation of these emissions leads to large uncertainties in such estimations. Many measurements have been made at the foliar but few at the ecosystem level, and those that do exist are limited in space and time. We here provide evidence that a simple remote sensing index, the photochemical reflectance index (PRI), which is indicative of light use efficiency (LUE), is a good indirect estimator of foliar isoprenoid emissions and therefore can be used to sense them remotely. These results open

  18. Scales used to rate adult patients' psycho-emotional status in tooth extraction procedures a systematic review.

    PubMed

    Astramskaitė, I; Juodžbalys, G

    2017-04-01

    The aim of this study was to review scales used to assess anxiety, stress, and pain in dental patients undergoing a tooth extraction procedure and to propose a novel psycho-emotional rating scale based on the relevant literature and our own experience. An electronic literature search was conducted of the National Library of Medicine database MEDLINE (Ovid) and EMBASE databases between January 2005 and April 2016. Sequential screening at the title/abstract and full-text levels was performed. The review included all human prospective or retrospective follow-up studies and clinical trials, cohort studies, case-control studies, and case series that demonstrated at least one scale used to measure tooth extraction anxiety, stress, or pain. The search resulted in 32 articles meeting the inclusion criteria. None of the studies were found to be suitable in evaluating patient's stress, pain, and fear at once. Also, no scales were found that included both the doctor's and the patient's rating. In a few studies, vital signs as psycho-emotional status indicators were rated. Guidelines for a suitable questionnaire that could be used for rating the psycho-emotional status of patients undergoing tooth extraction are listed in the present research. Further studies are required for verification and validation of offered scale.

  19. Dabigatran: A new oral anticoagulant. Guidelines to follow in oral surgery procedures. A systematic review of the literature

    PubMed Central

    Ramírez-Martínez-Acitores, Lucía; López-Pintor, Rosa Mª; Casañas-Gil, Elisabeth; Hernández-Vallejo, Gonzalo

    2016-01-01

    Background Dabigatran is a newly commercialized drug that is replacing other anticoagulants in the prevention of venous thromboembolism, stroke and systemic arterial valve embolism. It acts directly on thrombin presenting in a dynamic and predictable way, which does not require monitoring these patients. Therefore, we consider the need to assess whether their use increases the risk of bleeding involved before any dental treatment. Material and Methods We performed a systematic review with a bibliographic search in PubMed/Medline along with the Cochrane Library. We excluded articles dealing with all anticoagulants other than dabigatran, and works about surgical treatments in anatomical locations other than the oral cavity. Results We included a total of 13 papers of which 1 was a randomized clinical trial, 9 narrative literature reviews, 1 case series, 2 clinical cases and 1 expert opinion. Because we did not obtain any properly designed clinical trials, we were unable to conduct a meta-analysis. Conclusions Currently, there is no consensus on the procedure to be followed in patients taking dabigatran. However, all authors agree to treat each case individually in accordance to the risk of embolism, postoperative bleeding and renal function. Also, it is necessary to perform minimally invasive interventions, and take the appropriate local anti-hemolytic measures. Key words:Oral anticoagulants, dabigatran, risk of bleeding, oral surgery, dentistry. PMID:27694780

  20. Assessment of uterine cavity size and shape: a systematic review addressing relevance to intrauterine procedures and events.

    PubMed

    Goldstuck, Norman

    2012-09-01

    Uterine cavity measurement began with evaluation of post-mortem and surgical specimens. It has been extended in vivo by use of mechanical instruments and visualization techniques. This is a systematic review of the range of values for the uterine cavity and the practical implications of these measurements, Following a review of multiple data bases & a QUORUM analysis. Only articles with clearly defined quantitative measurements were included. Mechanical cavity measurements with a variety of instruments gave a mean endometrial cavity length (ECL) of 33.73 mm (18-22.1) and a mean endometrial cavity width (ECW) of 25.1 mm (17.8-32.2) for nulliparae. The values for multiparae were mean ECL 38.6mm(20.61-40.3) and mean ECW 34.9 mm (23.4-53). Imaging measurements for the uterine cavity by hysterography and ultrasound were mean ECL 44.3 mm (29-64) for multiparae and ECL 37 mm for nulliparae. Mean ECW was 28.2 mm (21-33) for nulliparae and 32.1 mm (26-38) for multiparae. There were wide variations due to parity, ethnicity and gestational states. Accurate measurement of intrauterine parameters is valuable for improving and enhancing many intrauterine procedures including IUD insertion, endometrial ablation, embryo placement in IVF and management of spontaneous and therapeutic abortion.

  1. A review of downscaling procedures - a contribution to the research on climate change impacts at city scale

    NASA Astrophysics Data System (ADS)

    Smid, Marek; Costa, Ana; Pebesma, Edzer; Granell, Carlos; Bhattacharya, Devanjan

    2016-04-01

    Human kind is currently predominantly urban based, and the majority of ever continuing population growth will take place in urban agglomerations. Urban systems are not only major drivers of climate change, but also the impact hot spots. Furthermore, climate change impacts are commonly managed at city scale. Therefore, assessing climate change impacts on urban systems is a very relevant subject of research. Climate and its impacts on all levels (local, meso and global scale) and also the inter-scale dependencies of those processes should be a subject to detail analysis. While global and regional projections of future climate are currently available, local-scale information is lacking. Hence, statistical downscaling methodologies represent a potentially efficient way to help to close this gap. In general, the methodological reviews of downscaling procedures cover the various methods according to their application (e.g. downscaling for the hydrological modelling). Some of the most recent and comprehensive studies, such as the ESSEM COST Action ES1102 (VALUE), use the concept of Perfect Prog and MOS. Other examples of classification schemes of downscaling techniques consider three main categories: linear methods, weather classifications and weather generators. Downscaling and climate modelling represent a multidisciplinary field, where researchers from various backgrounds intersect their efforts, resulting in specific terminology, which may be somewhat confusing. For instance, the Polynomial Regression (also called the Surface Trend Analysis) is a statistical technique. In the context of the spatial interpolation procedures, it is commonly classified as a deterministic technique, and kriging approaches are classified as stochastic. Furthermore, the terms "statistical" and "stochastic" (frequently used as names of sub-classes in downscaling methodological reviews) are not always considered as synonymous, even though both terms could be seen as identical since they are

  2. A review article on the benefits of early mobilization following spinal surgery and other medical/surgical procedures

    PubMed Central

    Epstein, Nancy E.

    2014-01-01

    Background: The impact of early mobilization on perioperative comorbidities and length of stay (LOS) has shown benefits in other medical/surgical subspecialties. However, few spinal series have specifically focused on the “pros” of early mobilization for spinal surgery, other than in acute spinal cord injury. Here we reviewed how early mobilization and other adjunctive measures reduced morbidity and LOS in both medical and/or surgical series, and focused on how their treatment strategies could be applied to spinal patients. Methods: We reviewed studies citing protocols for early mobilization of hospitalized patients (day of surgery, first postoperative day/other) in various subspecialties, and correlated these with patients’ perioperative morbidity and LOS. As anticipated, multiple comorbid factors (e.g. hypertension, high cholesterol, diabetes, hypothyroidism, obesity/elevated body mass index hypothyroidism, osteoporosis, chronic obstructive pulmonary disease, coronary artery disease and other factors) contribute to the risks and complications of immobilization for any medical/surgical patient, including those undergoing spinal procedures. Some studies additionally offered useful suggestions specific for spinal patients, including prehabilitation (e.g. rehabilitation that starts prior to surgery), preoperative and postoperative high protein supplements/drinks, better preoperative pain control, and early tracheostomy, while others cited more generalized recommendations. Results: In many studies, early mobilization protocols reduced the rate of complications/morbidity (e.g. respiratory decompensation/pneumonias, deep venous thrombosis/pulmonary embolism, urinary tract infections, sepsis or infection), along with the average LOS. Conclusions: A review of multiple medical/surgical protocols promoting early mobilization of hospitalized patients including those undergoing spinal surgery reduced morbidity and LOS. PMID:24843814

  3. Successful Management of Two Cases of Placenta Accreta and a Literature Review: Use of the B-Lynch Suture and Bilateral Uterine Artery Ligation Procedures

    PubMed Central

    Arab, Maliheh; Ghavami, Behnaz; Saraeian, Samaneh; Sheibani, Samaneh; Abbasian Azar, Fatemeh; Hosseini-Zijoud, Seyed-Mostafa

    2016-01-01

    Introduction Placenta accreta is an increasingly common complication of pregnancy that can result in massive hemorrhage. Case Presentation We describe two cases of placenta accreta, with successful conservative management in a referral hospital in Tehran, Iran. In both cases, two procedures were performed: compression suture (B-Lynch) and a perfusion-decreasing procedure (bilateral uterine artery ligation). We also present the results of a narrative literature review. Conclusions The double B-Lynch and uterine arterial ligation procedure in cases of abnormal placentation might be strongly considered in fertility preservation, coagulopathy, coexisting medical disease, blood access shortage, low surgical experience, distant local hospitals, and no help. PMID:27354921

  4. Numerical simulation for horizontal subsurface flow constructed wetlands: A short review including geothermal effects and solution bounding in biodegradation procedures

    NASA Astrophysics Data System (ADS)

    Liolios, K.; Tsihrintzis, V.; Angelidis, P.; Georgiev, K.; Georgiev, I.

    2016-10-01

    Current developments on modeling of groundwater flow and contaminant transport and removal in the porous media of Horizontal Subsurface Flow Constructed Wetlands (HSF CWs) are first reviewed in a short way. The two usual environmental engineering approaches, the black-box and the process-based one, are briefly presented. Next, recent research results obtained by using these two approaches are briefly discussed as application examples, where emphasis is given to the evaluation of the optimal design and operation parameters concerning HSF CWs. For the black-box approach, the use of Artificial Neural Networks is discussed for the formulation of models, which predict the removal performance of HSF CWs. A novel mathematical prove is presented, which concerns the dependence of the first-order removal coefficient on the Temperature and the Hydraulic Residence Time. For the process-based approach, an application example is first discussed which concerns procedures to evaluate the optimal range of values for the removal coefficient, dependent on either the Temperature or the Hydraulic Residence Time. This evaluation is based on simulating available experimental results of pilot-scale units operated in Democritus University of Thrace, Xanthi, Greece. Further, in a second example, a novel enlargement of the system of Partial Differential Equations is presented, in order to include geothermal effects. Finally, in a third example, the case of parameters uncertainty concerning biodegradation procedures is considered and the use of upper and a novel approach is presented, which concerns the upper and the lower solution bound for the practical draft design of HSF CWs.

  5. A review of studies comparing three laparoscopic procedures in bariatric surgery: sleeve gastrectomy, Roux-en-Y gastric bypass and adjustable gastric banding.

    PubMed

    Franco, Juan Victor A; Ruiz, Pablo Adrian; Palermo, Mariano; Gagner, Michel

    2011-09-01

    Obesity is a major worldwide problem in public health, reaching epidemic proportions in many countries, especially in urbanized regions. Bariatric procedures have been shown to be more effective in the management of morbid obesity, compared to medical treatments in terms of weight loss and its sustainability. The two most commonly performed procedures are laparoscopic Roux-en-Y gastric bypass (LRYGB), laparoscopic adjustable gastric banding (LAGB), and the novel laparoscopic sleeve gastrectomy (LSG). The MEDLINE database (cutoff date September 2010), LILACS, and the Cochrane Library were searched using the key words "gastric bypass," "sleeve gastrectomy," and "gastric banding." Only studies that compared at least two of the laparoscopic procedures were included. Reviews and meta-analysis, editorial letters or comments, case reports, animal or in vitro studies, comparisons with medical treatment, comparisons with open (non-laparoscopic) procedures were excluded. Most studies indicated that LRYGB and LSG could be more effective achieving weight loss than LAGB. However, LAGB seems to be a safer procedure with frequent, but less severe, long-term complications. Although not uniformly reported, a resolution of obesity-related comorbidities was achieved with most bariatric procedures. The three procedures have acceptable efficacy and safety. We believe that patients should be informed in detail on the advantages and disadvantages of each available procedure, possibly in several interviews and always accompanied by a specialized interdisciplinary team, warranting long-term follow-up.

  6. Peri- and intraarticular analgesia (PIA) superior to other procedures in TKA – review of literature and results of own RCT

    PubMed Central

    Beckmann, J.; Stathellis, A.; Fitz, W.; Köck, F.; Bauer, G.; Gebauer, M.; Schnurr, C.

    2016-01-01

    Background: TKA is a worldwide established surgery with periarticular infiltrations being scientifically funded is the superiority of in the perioperative setup of TKA nowadays. However, nerve blocks are still widely used as perioperative standard meaning possible analgesia beyond surger, but simultaneously with sensomotoric deficiency and resulting risk of fall as well as increased pain after removal of nerval catheters. Also a standard procedure is intubation which means immediate pain after awakening of patients with resulting need for sufficient oral, intravenous, intramuscular or subcutaneous analgesia. We present an actual review of the literature and an own RCT comparing infiltrations with nerve blocks, which to our best knowledge presents the first RCT combined with an additional continous part. Methods: Literature review (PubMed)Own RCT: 50 TKA were randomized and prospectively included. 25 patients received nerve blocks with a single ischiadicus block and a femoralis block with additional perineural catheter. 25 patients received periarticular infiltrations together with an intraarticular catheter (PIA). All catheters stayed for 4 days. Both groups received a laryngeal masc. Postoperative mobilisation, surgeon and type of prosthesis were the same in all patients. The following was evaluated pre- and postoperatively (first, third and sixth hour, first until sixth day): VAS, additional analgetics/ opioids, KSS score, knee function and ability to raise the straightened leg. Complications as infection, falls, DVT etc. were recorded. Results: Periarticular infiltrations are superior to other options in the perioperative setup of TKA which is clearly shown by literature (several studies including reviews) as well as the results of our own RCT: Pain occured in both groups, however, VAS, additional analgetics/ opioids and KSS score as well as the ability to raise the straightened leg were significantly better following PIA (p<0,01), with comparable knee function

  7. Increasing the Rigor of Procedural Fidelity Assessment: An Empirical Comparison of Direct Observation and Permanent Product Review Methods

    ERIC Educational Resources Information Center

    Sanetti, Lisa M. Hagermoser; Collier-Meek, Melissa A.

    2014-01-01

    Although it is widely accepted that procedural fidelity data are important for making valid decisions about intervention effectiveness, there is little empirical guidance for researchers and practitioners regarding how to assess procedural fidelity. A first step in moving procedural fidelity assessment research forward is to develop a…

  8. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  9. 42 CFR 137.297 - If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... environmental laws, not the Self-Governance Tribe. ... 42 Public Health 1 2010-10-01 2010-10-01 false If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe, is the Self-Governance Tribe responsible for ensuring...

  10. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  11. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  12. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  13. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  14. A Review of ETS Differential Item Functioning Assessment Procedures: Flagging Rules, Minimum Sample Size Requirements, and Criterion Refinement. Research Report. ETS RR-12-08

    ERIC Educational Resources Information Center

    Zwick, Rebecca

    2012-01-01

    Differential item functioning (DIF) analysis is a key component in the evaluation of the fairness and validity of educational tests. The goal of this project was to review the status of ETS DIF analysis procedures, focusing on three aspects: (a) the nature and stringency of the statistical rules used to flag items, (b) the minimum sample size…

  15. iStent as a Solo Procedure for Glaucoma Patients: A Systematic Review and Meta-Analysis

    PubMed Central

    Malvankar-Mehta, Monali S.; Chen, Yufeng Nancy; Iordanous, Yiannis; Wang, Wan Wendy; Costella, John; Hutnik, Cindy M. L.

    2015-01-01

    Background Glaucoma is a leading cause of irreversible blindness. It is firmly entrenched in the traditional treatment paradigm to start with pharmacotherapy. However, pharmacotherapy is not benign and has been well documented to have a number of significant challenges. Minimally invasive glaucoma surgery (MIGS) that targets the outflow pathway with minimal to no scleral dissection has resulted in the need to reconsider the glaucoma treatment paradigm. Purpose To perform a systematic review and meta-analysis to evaluate and quantify the effect on post-operative intraocular pressure (IOP) and number of topical glaucoma medications, in patients receiving the iStent MIGS device as the solo procedure without concurrent cataract surgery. Methods A systematic review was conducted by searching various databases between January 1, 2000, and June 30, 2014. Studies reporting up to a maximum follow-up period of 24 months were retrieved and screened using the EPPI-Reviewer 4 gateway. Percentage reduction in IOP (IOPR%), and mean reduction in topical glaucoma medications after surgery were computed. Meta-analysis was performed using STATA v. 13.0. The standardized mean difference (SMD) was calculated as the effect size for continuous scale outcomes. Heterogeneity was determined using the I2 statistics, Z-value, and χ2 statistics. Fixed-effect and random-effect models were developed based on heterogeneity. Sub-group analysis was performed based on the number of iStents implanted and the follow-up period. The outcome measures were changes in the IOP and number of glaucoma medications. Results The search strategy identified 105 records from published literature and 9 records from the grey literature. Five studies with 248 subjects were included for quantitative synthesis. A 22% IOP reduction (IOPR%) from baseline occurred at 18-months after one iStent implant, 30% at 6-months after two iStents implantations, and 40% at 6-months after implantation of three iStents. A mean

  16. The combined use of sucrose and nonnutritive sucking for procedural pain in both term and preterm neonates: an integrative review of the literature.

    PubMed

    Naughton, Kelli Ann

    2013-02-01

    Many agents, both pharmacologic and nonpharmacologic, have been studied to alleviate neonatal pain, and the research is extensive. The 2 most commonly studied nonpharmacologic agents studied have been sucrose and nonnutritive sucking (NNS). There is increasing evidence that the synergistic effect of sucrose and NNS is more effective than the effect of sucrose or NNS alone. The purpose of this integrative review of the literature was to determine whether there is a relationship between the synergistic effect of combining sucrose and NNS administered before and during painful procedures, and reducing procedural pain in both preterm and term neonates. This integrative review indicates that the combination of sucrose and NNS is a safe, effective, and clinically significant means of providing procedural pain relief in neonates, both term and preterm.

  17. Dental Procedures.

    PubMed

    Ramponi, Denise R

    2016-01-01

    Dental problems are a common complaint in emergency departments in the United States. There are a wide variety of dental issues addressed in emergency department visits such as dental caries, loose teeth, dental trauma, gingival infections, and dry socket syndrome. Review of the most common dental blocks and dental procedures will allow the practitioner the opportunity to make the patient more comfortable and reduce the amount of analgesia the patient will need upon discharge. Familiarity with the dental equipment, tooth, and mouth anatomy will help prepare the practitioner for to perform these dental procedures.

  18. The N-terminal domain of DnaT, a primosomal DNA replication protein, is crucial for PriB binding and self-trimerization.

    PubMed

    Huang, Yen-Hua; Huang, Cheng-Yang

    2013-12-13

    DnaT and PriB are replication restart primosomal proteins required for re-initiating chromosomal DNA replication in bacteria. Although the interaction of DnaT with PriB has been proposed, which region of DnaT is involved in PriB binding and self-trimerization remains unknown. In this study, we identified the N-terminal domain in DnaT (aa 1-83) that is important in PriB binding and self-trimerization but not in single-stranded DNA (ssDNA) binding. DnaT and the deletion mutant DnaT42-179 protein can bind to PriB according to native polyacrylamide gel electrophoresis, Western blot analysis, and pull-down assay, whereas DnaT84-179 cannot bind to PriB. In contrast to DnaT, DnaT26-179, and DnaT42-179 proteins, which form distinct complexes with ssDNA of different lengths, DnaT84-179 forms only a single complex with ssDNA. Analysis of DnaT84-179 protein by gel filtration chromatography showed a stable monomer in solution rather than a trimer, such as DnaT, DnaT26-179, and DnaT42-179 proteins. These results constitute a pioneering study of the domain definition of DnaT. Further research can directly focus on determining how DnaT binds to the PriA-PriB-DNA tricomplex in replication restart by the hand-off mechanism.

  19. A midtrimester procedure, not without its risks... Saline abortion: a review of the experience at Kapiolani hospital.

    PubMed

    Hooper, T I; Smith, R G; Pion, R J

    1973-01-01

    The experience with 107 saline instillation abortions at Kapiolani Maternity and Gynecologic Hospital in Honolulu, during the first 7 months of 1972 is reviewed. 57.9% of the patients were primigravidas and 40.2% were multigravidas. Estimated length of gestation ranged from 14 to 23 weeks, with a mean of 17.7. 87/8% of the women were successfully aborted on the initial attempt, while technical difficulty with amniocentesis prevented the instillation of saline in 10.3%, and the method itself failed for 2. 30% of the primary attempts at abortion failed when gestation length was estimated at 15 to 16 weeks compared to a 7% failure rate at 17 to 18 weeks; no failures occurred at 19 weeks or more. Mean induction-abortion interval was 25.7 hours; gravidity appeared to exert little influence. 32.7% of the patients displayed postabortive complications which were defined by the following criteria: 1) failure of amniocentesis or failure to abort; 2) accidental intravascular injection of saline and immediate reaction consistent with this clinical syndrome; 3) fever, any recorded temperature of 100.6 degrees Farenheit or greater; 4) retained tissue; 5) hemorrhage, a decrease in hemoglobin of 2 gm or more. 14% of the women developed fever while failed abortion occurred for 12.1% and 10.3% displayed more than 1 complication. The highest complication rate (40%) occurred in 13-16 week gestation group; the lowest (29.6%) in the 17-20 weeks interval. A greater risk was found to exist for the very young patient (15 years and under) and the older patient (age 30 and over); complication rates were 50% and 40% respectively, compared to a rate of 25% for age 29. The group of patients having greater than 150 cc of amniotic fluid removed and greater than 150 cc of hypertonic saline instilled had the shortest interval to abortion. While complications encountered in this series of 107 patients were mainly minor, it should be noted that the incidence of these complications as well as the

  20. Pri-miR-17-92a transcript folds into a tertiary structure and autoregulates its processing

    PubMed Central

    Chakraborty, Saikat; Mehtab, Shabana; Patwardhan, Anand; Krishnan, Yamuna

    2012-01-01

    MicroRNAs control gene expression either by RNA transcript degradation or translational repression. Expressions of miRNAs are highly regulated in tissues, disruption of which leads to disease. How this regulation is achieved and maintained is still largely unknown. MiRNAs that reside on clustered or polycistronic transcripts represent a more complex case where individual miRNAs from a cluster are processed with different efficiencies despite being cotranscribed. To shed light on the regulatory mechanisms that might be operating in these cases, we considered the long polycistronic primary miRNA transcript pri-miR-17-92a that contains six miRNAs with diverse functions. The six miRNA domains on this cluster are differentially processed to produce varying amounts of resultant mature miRNAs in different tissues. How this is achieved is not known. We show, using various biochemical and biophysical methods coupled with mutational studies, that pri-miR-17-92a adopts a specific three-dimensional architecture that poses a kinetic barrier to its own processing. This tertiary structure could create suboptimal protein recognition sites on the pri-miRNA cluster due to higher-order structure formation. PMID:22450760

  1. A systematic review of tongue base suspension techniques as an isolated procedure or combined with uvulopalatopharyngoplasty in obstructive sleep apnea.

    PubMed

    Bostanci, Asli; Turhan, Murat

    2016-10-01

    We aimed to evaluate existing research into the effectiveness and safety of two tongue base suspension (TBS) techniques (Repose(®) system and modified TBS) with or without uvulopalatopharyngoplasty (UPPP) in obstructive sleep apnea. The literature review was performed using PubMed database. Searched terms used included the keywords "sleep apnea", "surgery", "tongue", "tongue base", "suspension", "Repose", "uvulopalatopharyngoplasty", and "hypopharynx". Levels of evidences and grades of recommendations were determined according to the hierarchy proposed by Oxford Centre for Evidence-based Medicine. Seven studies including 113 patients met the eligibility criteria for TBS as a stand-alone procedure. Four of seven studies including 62 patients used the Repose(®), and three studies including 51 patients used the modified TBS. The success rates were higher in the studies that used modified technique (74.5 %) than those that used the Repose(®) (25.8 %), (p < 0.001). Ten studies including 300 patients met the eligibility criteria for TBS combined with UPPP. Seven of ten studies including 176 patients used the Repose(®), and three studies including 124 patients used the modified TBS. The success rates in this group were similar between the modified TBS (73.4 %) and Repose(®) (67.6 %), (p = 0.341). When aggregate data of 413 patients were compared, the modified TBS was found to be associated with significantly higher success rates (73.7 vs. 56.7 %, p < 0.001). The evidence supports primarily grade C recommendations for the benefits of both techniques with or without UPPP; although there is a trend toward improved outcome with modified technique.

  2. Imaging Review of Procedural and Periprocedural Complications of Central Venous Lines, Percutaneous Intrathoracic Drains, and Nasogastric Tubes

    PubMed Central

    Al-Jahdali, Hamdan; Irion, Klaus L.; Allen, Carolyn; de Godoy, Daniel Marafiga; Khan, Ali Nawaz

    2012-01-01

    Placements of central venous lines (CVC), percutaneous intrathoracic drains (ITDs), and nasogastric tubes (NGTs) are some of the most common interventional procedures performed on patients that are unconscious and in almost all intensive care/high dependency patients in one form or the other. These are standard procedures within the remit of physicians, and other trained health professionals. Procedural complications may occur in 7%–15% of patients depending upon the intervention and experience of the operator. Most complications are minor, but other serious complications may add significantly to morbidity and even mortality of already compromised patients. Imaging findings are the key to the detection of misplaced lines, and tubes and their prompt recognition are vital to avoid harm to the patient. It is, therefore, pertinent that healthcare professionals who perform these procedures are familiar with imaging complications of these procedures. Here, we present the imaging characteristics of procedural complications. PMID:22970363

  3. Report of the M16 Rifle Review Panel. Volume 2, Appendix 1. Small Arms Test Policies and Procedures

    DTIC Science & Technology

    1968-06-01

    Policies and Procedures Table of Contents A. Introduction B. Test Policies and Procedures As Applied to the M16, 1962-1966 C. Current Policies...SMALL ARMS TEST POLICIES AND PROCEDURES A. Introduction The purpose of this appendix Is to describe changes that have been made In the testing...smooth introduction of commer- cially developed items into the Army. Responsibilities for Testing No one DA staff agency was responsible for all

  4. The Use of Thrombopoietin Receptor Agonists for Correction of Thrombocytopenia prior to Elective Procedures in Chronic Liver Diseases: Review of Current Evidence

    PubMed Central

    Meillier, Andrew

    2016-01-01

    Patients with chronic liver diseases (CLD) undergo a range of invasive procedures during their clinical lifetime. Various hemostatic abnormalities are frequently identified during the periprocedural work-up; including thrombocytopenia. Thrombocytopenia of cirrhosis is multifactorial in origin, and decreased activity of thrombopoietin has been identified to be a major cause. Liver is an important site of thrombopoietin production and its levels are decreased in patients with cirrhosis. Severe thrombocytopenia (platelet counts < 60–75,000/µL) is associated with increased risk of bleeding with invasive procedures. In recent years, compounds with thrombopoietin receptor agonist activity have been studied as therapeutic options to raise platelet counts in CLD. We reviewed the use of Eltrombopag, Romiplostim, and Avatrombopag prior to various invasive procedures in patients with CLD. These agents seem promising in raising platelet counts before elective procedures resulting in reduction in platelet transfusions, and they also enabled more patients to undergo the procedures. However, these studies were not primarily aimed at comparing bleeding episodes among groups. Use of these agents had some adverse consequences, importantly being the occurrence of portal vein thrombosis. This review highlights the need of further studies to identify reliable methods of safely reducing the provoked bleeding risk linked to thrombocytopenia in CLD. PMID:27800187

  5. Graft Rejection Rate and Graft Failure Rate of Penetrating Keratoplasty (PKP) vs Lamellar Procedures: A Systematic Review

    PubMed Central

    Akanda, Zarique Z.; Naeem, Abdul; Russell, Elizabeth; Belrose, Jillian; Si, Francie F.; Hodge, William G.

    2015-01-01

    Purpose The aim of our investigation was to conduct a quantitative meta-analysis of the present world literature comparing the major surgical outcomes of penetrating keratoplasty (PKP) to lamellar procedures. Our goal is that clinicians, eye bank administrators, and health policy makers will be able to utilize this study in implementing decisions in regards to corneal transplantation. Methods Pooled measures of association were with odds ratios and because of study heterogeneity, the pooled effects were assumed to follow a random effects model (DerSimonian-Laird). The comparisons were between 1) PKP’s and all lamellar procedures (anterior AND posterior) and then 2) between PKP’s and all anterior lamellar procedures and 3) PKP and all posterior lamellar procedures. Results For PKP vs anterior lamellar procedures, the pooled odds ratio for rejection of PKP over lamellar keratoplasty (LK) was 3.56 (95% CI: 1.76-7.20) and for outright failure, the pooled odds ratio of PKP failure vs LK was 2.85 (95% CI: 0.84-9.66). For posterior lamellar procedures, the pooled odds ratio for rejection of PKP over LK was 1.52 (95% CI: 1.00-2.32). The pooled odds ratio for outright failure of PKP over posterior lamellar procedures was 2.09 (95% CI: 0.57-7.59). The follow up time was significantly longer for full transplants than for lamellar procedures. Conclusions For both anterior and posterior lamellar procedures, the odds ratios comparing rejection of full transplants to lamellar procedures (both anterior and posterior individually) were significantly higher in the PKP group. For outright failure, the PKP group also had a higher risk of failure than the lamellar groups but this was not statistically significant in either instance (anterior or posterior). Some of the clinical differences benefitting lamellar procedures may at least be partly explained by follow up time differences between groups and this needs to be accounted for more rigorously in future studies. PMID:25781319

  6. 38 CFR 16.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of research proposals which have been approved under the procedure. (d) The department or agency head... procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 16.110 Section 16.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF...

  7. Beyond Synthesis: Augmenting Systematic Review Procedures with Practical Principles to Optimise Impact and Uptake in Educational Policy and Practice

    ERIC Educational Resources Information Center

    Green, Chris; Taylor, Celia; Buckley, Sharon; Hean, Sarah

    2016-01-01

    Whilst systematic reviews, meta-analyses and other forms of synthesis are considered amongst the most valuable forms of research evidence, their limited impact on educational policy and practice has been criticised. In this article, we analyse why systematic reviews do not benefit users of evidence more consistently and suggest how review teams…

  8. 36 CFR 1260.58 - What are the procedures for requesting a mandatory review of White House originated information?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requesting a mandatory review of White House originated information? 1260.58 Section 1260.58 Parks, Forests... review of White House originated information? (a) Requests for mandatory review must describe the...) NARA will promptly acknowledge to the requester the receipt of a request for White House...

  9. Independent Auditor’s Report on the Agreed-Upon Procedures for Reviewing the FY 2014 Civilian Payroll Withholding Data and Enrollment Information

    DTIC Science & Technology

    2014-09-26

    five individuals who are under the Federal Employees [Retirement System]–Revised Annuity Employees system (FERS- RAE ) to test that their FERS- RAE ...Federal employees covered by FERS- RAE – effective date January 1, 2013. For more information and the FERS- RAE contribution rates, see BAL 12-104...by FERS include employees covered by FERS- RAE which became effective January 1, 2013. We performed separate procedures to review Federal Employees

  10. Review of Corneal Endothelial Specular Microscopy for FDA Clinical Trials of Refractive Procedures, Surgical Devices and New Intraocular Drugs and Solutions

    PubMed Central

    McCarey, Bernard E.; Edelhauser, Henry F.; Lynn, Michael J.

    2010-01-01

    Specular microscopy can provide a non-invasive morphological analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiological reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corneal endothelium. The purpose of this review is to discuss normal and stressed endothelial cell morphology, the techniques for determining the morphology parameters, and clinical trial applications. PMID:18245960

  11. Report from the Committee of Visitors on its Review of the Processes and Procedures used to Manage the Theory and Computations Program, Fusion Energy Sciences Advisory Committee

    SciTech Connect

    none,

    2004-03-01

    A Committee of Visitors (COV) was formed to review the procedures used by the Office of Fusion Energy Sciences to manage its Theory and Computations program. The COV was pleased to conclude that the research portfolio supported by the OFES Theory and Computations Program was of very high quality. The Program supports research programs at universities, research industries, and national laboratories that are well regarded internationally and address questions of high relevance to the DOE. A major change in the management of the Theory and Computations program over the past few years has been the introduction of a system of comparative peer review to guide the OFES Theory Team in selecting proposals for funding. The COV was impressed with the success of OFES in its implementation of comparative peer review and with the quality of the reviewers chosen by the OFES Theory Team. The COV concluded that the competitive peer review process has improved steadily over the three years that it has been in effect and that it has improved both the fairness and accountability of the proposal review process. While the COV commends OFES in its implementation of comparative review, the COV offers the following recommendations in the hope that they will further improve the comparative peer review process: The OFES should improve the consistency of peer reviews. We recommend adoption of a “results-oriented” scoring system in their guidelines to referees (see Appendix II), a greater use of review panels, and a standard format for proposals; The OFES should further improve the procedures and documentation for proposal handling. We recommend that the “folders” documenting funding decisions contain all the input from all of the reviewers, that OFES document their rationale for funding decisions which are at variance with the recommendation of the peer reviewers, and that OFES provide a Summary Sheet within each folder; The OFES should better communicate the procedures used to

  12. Pain management in the neonatal piglet during routine management procedures. Part 1: a systematic review of randomized and non-randomized intervention studies.

    PubMed

    Dzikamunhenga, R S; Anthony, R; Coetzee, J; Gould, S; Johnson, A; Karriker, L; McKean, J; Millman, S T; Niekamp, S R; O'Connor, A M

    2014-06-01

    Routine procedures carried out on piglets (i.e. castration, tail docking, teeth clipping, and ear notching) are considered painful. Unfortunately the efficacy of current pain mitigation modalities is poorly understood. The aim of this systematic review was to synthesize the existing primary scientific literature regarding the effectiveness of pain management interventions used for routine procedures on piglets. The review question was, 'In piglets under twenty-eight days old, undergoing castration, tail docking, teeth clipping, and/or methods of identification that involve cutting of the ear tissue, what is the effect of pain mitigation compared with no pain mitigation on behavioral and non-behavioral outcomes that indicate procedural pain and post-procedural pain?' A review protocol was designed a priori. Data sources used were Agricola (EBSCO), CAB Abstracts (Thomson Reuters), PubMed, Web of Science (Thomson Reuters), BIOSIS Previews (Thomson Reuters), and ProQuest Dissertations & Theses Full Text. No restrictions on year of publication or language were placed on the search. Eligible studies assessed an intervention designed to mitigate the pain of the procedures of interest and included a comparison group that did not receive an intervention. Eligible non-English studies were translated using a translation service. Two reviewers independently screened titles and abstracts for relevance using pre-defined questions. Data were extracted from relevant articles onto pre-defined forms. From the 2203 retrieved citations forty publications, containing 52 studies met the eligibility criteria. In 40 studies, piglets underwent castration only. In seven studies, piglets underwent tail docking only. In one study, piglets underwent teeth clipping only, and in one study piglets underwent ear notching only. Three studies used multiple procedures. Thirty-two trial arms assessed general anesthesia protocols, 30 trial arms assessed local anesthetic protocols, and 28 trial arms

  13. Linking chlorophyll fluorescence, hyperspectral reflectance and plant physiological responses to detect stress using the photochemical reflectance index (PRI) (Invited)

    NASA Astrophysics Data System (ADS)

    Naumann, J. C.; Young, D.; Anderson, J.

    2009-12-01

    The concept of using vegetation as sentinels to indicate natural or anthropogenic stress is not new and could potentially provide an ideal mechanism for large-scale detection. Advances in fluorescence spectroscopy and reflectance-derived fluorescence have made possible earlier detection of stress in plants, especially before changes in chlorophyll content are visible. Our studies have been used to fuse leaf fluorescence and reflectance characteristics to remotely sense and rapidly detect vegetation stress and terrain characteristics. Laboratory studies have indicated that light-adapted fluorescence (ΔF/F‧m) measurements have been successful in all experiments at detecting stress from flooding, salinity, drought, herbicide and TNT contamination prior to visible signs of damage. ΔF/F‧m was related to plant physiological status in natural stress conditions, as seen in the relationships with stomatal conductance and photosynthesis The photochemical reflectance index (PRI) and other reflectance ratios were effective at tracking changes in ΔF/F‧m at the leaf and canopy-level scales. At the landscape-level, chlorophyll fluorescence and airborne reflectance imagery were used to evaluate spatial variations in stress in the dominant shrub on a barrier island, Myrica cerifera, during a severe drought and compared to an extremely wet year. Measurements of relative water content and the water band index (WBI970) indicated that water stress did not vary across the island. In contrast, there were significant differences in tissue chlorides across sites. Using PRI we were able to detect salinity stress across the landscape. PRI did not differ between wet and dry years. There was a positive relationship between PRI and ΔF/F‧m for M. cerifera (r2 = 0.79). The normalized difference vegetation index (NDVI), the chlorophyll index (CI) and WBI970 were higher during the wet summer but varied little across the island. PRI was not significantly related to NDVI, suggesting that

  14. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... review process for LNG terminal facilities and other natural gas facilities prior to filing of applications. (a) LNG terminal facilities and related jurisdictional natural gas facilities. A...

  15. Diabetic Foot Ulcers Combination with Lower Limb Lymphedema Treated by Staged Charles Procedure: Case Report and Literature Review

    PubMed Central

    Lin, Chin-Ta; Ou, Kuang-Wen; Chang, Shun-Cheng

    2013-01-01

    Primary or secondary, lymphedema is lymphatic dysfunction which results in protein-rich interstitial fluid accumulated in the skin and subcutaneous tissue. In developed countries, surgical resection of regional lymph nodes or chronic inflammation process is the most common etiology of lymphedema instead of parasite infection seen in developing countries. Patients with lymphedema sustain either cosmetic or functional problems, and several studies have indicated the potential risk, though not high, transforming lymphedema to lymphangiosarcoma. Here we introduce a simple idea with staged Charles procedure by a case report to decrease the size of wound healing in each procedure and decreasing the rate of surgical complication. PMID:24353689

  16. Registering medicines for low-income countries: how suitable are the stringent review procedures of the World Health Organisation, the US Food and Drug Administration and the European Medicines Agency?

    PubMed

    Doua, Joachim Y; Van Geertruyden, Jean-Pierre

    2014-01-01

    New medicines are registered after a resource-demanding process. Unfortunately, in low-income countries (LICs), demand outweighs resources. To facilitate registration in LICs, stringent review procedures of the European Medicines Agency (EMA Article-58), Food and Drug Administration (FDA PEPFAR-linked review) and WHO Prequalification programme have been established. Only the PEPFAR-linked review gives approval, while the others make recommendations for approval. This study assessed the performance and discussed the challenges of these three stringent review procedures. Data from WHO, FDA, EMA, Medline and Internet were analysed. Over 60% of medicines reviewed by stringent review procedures are manufactured in India. Until 2012, WHO prequalified 400 medicines (211 vaccines, 130 antiretrovirals, 29 tuberculostatics, 15 antimalarials and 15 others). PEPFAR-linked review approved 156 antiretrovirals, while EMA Article 58 recommended approval of 3 antiretrovirals, 1 vaccine and 1 antimalarial. WHO Prequalification and PEPFAR-linked review are free of charge and as a result have accelerated access to antiretrovirals. They both built capacity in sub-Saharan Africa, although WHO prequalification relies technically on stringent regulatory authorities and financially on donors. Article-58 offers the largest disease coverage and strongest technical capacities, is costly and involves fewer LICs. To meet the high demand for quality medicines in LICs, these stringent review procedures need to enlarge their disease coverage. To improve registration, EMA Article 58 should actively involve LICs. Furthermore, LIC regulatory activities must not be fully resigned to stringent review procedure.

  17. 34 CFR 222.95 - How are Indian policies and procedures reviewed to ensure compliance with the requirements in...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ensure compliance with the requirements in section 8004(a) of the Act? 222.95 Section 222.95 Education... Children Residing on Indian Lands Indian Policies and Procedures § 222.95 How are Indian policies and... comply with the provisions of section 8004(a) and § 222.94. (b) If the Director determines either...

  18. Periprocedural management of anticoagulation in patients taking novel oral anticoagulants: Review of the literature and recommendations for specific populations and procedures.

    PubMed

    Mar, Philip L; Familtsev, Dmitry; Ezekowitz, Michael D; Lakkireddy, Dhanunjaya; Gopinathannair, Rakesh

    2016-01-01

    An increasing number of individuals are on novel oral anticoagulants (NOAC) for anticoagulation instead of vitamin K antagonists (VKA) and roughly 10% of these individuals will require interruption of these agents for procedures annually. Recent evidence surrounding bridging as well as the FDA approval of a new NOAC call for a comprehensive review and update regarding periprocedural NOAC management. The periprocedural management of NOACs involves striking a balance between the risks of bleeding and thromboembolism associated with interruption, bridging, and reinitiation of anticoagulation. NOACs have a distinct pharmacokinetic advantage in this setting with their quick onset and elimination from the body. Procedures at low risk for bleeding do not require interruption and can be scheduled at the start of the next dosing interval. Procedures at moderate-high risk of bleeding require interruption of NOAC for 5 half lives prior to the procedure to allow for adequate elimination of the drug. In light of new evidence highlighting the risks of bleeding, and given shorter "unprotected" times with NOAC interruption versus VKA, patients at low-moderate risk for thromboembolism should not be bridged when "unprotected" time is less than 96 h. For patients at high risk for thromboembolism, individual patient and surgical factors need to be considered before the decision to bridge is made. The benefit of bridging these patients who have a considerable risk of bleeding may not outweigh the benefits. Focused randomized studies on periprocedural management of NOACs are urgently needed.

  19. [Peer review procedures in pathology - more than ten years of experience in the free state of Saxony].

    PubMed

    Eberlein-Gonska, Maria; Baretton, Gustavo; Habeck, Jörg-Olaf

    2012-01-01

    The positive experiences regarding peer review practice go back to the 1990s and can be traced in the position paper of the German Medical Association concerning quality assurance in the field of pathology. This evolved into the initiative of pathologists in Saxony to implement the peer review practice within the remit of their State Medical Association. Since the 14(th) of May 1999 various institutes as well as medical group practices in pathology and cytology have joined forces to undertake voluntary inter-institutional quality control measures. The aim was to improve the process and especially the outcome quality by reviewing each other's quality (analysing samples) on the basis of defined criteria. A positive review outcome report, which will have to be unanimously agreed upon by all participants, will lead to a positive recommendation for a certificate issued by the Medical Association of Saxony. Between 1999 and 2011 a total of 56 peer review proceedings took place. The potentials for improvement concern the problem of "kitchen pathology" still being used in the context of macroscopic description, the quality of microscopic description including the use of correct nomenclature, the quality of tumour classification and immune histological investigations. Statements concerning the advantage of the peer review method in particular refer to the integration of resident pathologists. Due to the long period of implementation of the peer review system und the small number of proceedings, it is not possible to come to a clear conclusion about the improvement or deterioration of quality. During a period of more than 10 years three peer review proceedings were not successful. In this situation, it is appropriate to ask the question of how restrictive peer reviews should be. The three most important aspects for the pathologists in Saxony are: self-determination, learning from each other, and a commitment to quality improvement. So this method set an example of how a

  20. Prediction of moment-rotation characteristic of top- and seat-angle bolted connection incorporating prying action

    NASA Astrophysics Data System (ADS)

    Ahmed, Ali

    2017-03-01

    Finite element (FE) analyses were performed to explore the prying influence on moment-rotation behaviour and to locate yielding zones of top- and seat-angle connections in author's past research studies. The results of those FE analyses with experimental failure strategies of the connections were used to develop failure mechanisms of top- and seat-angle connections in the present study. Then a formulation was developed based on three simple failure mechanisms considering bending and shear deformations, effects of prying action on the top angle and stiffness of the tension bolts to estimate rationally the ultimate moment M u of the connection, which is a vital parameter of the proposed four-parameter power model. Applicability of the proposed formulation is assessed by comparing moment-rotation ( M- θ r ) curves and ultimate moment capacities with those measured by experiments and estimated by FE analyses and three-parameter power model. This study shows that proposed formulation and Kishi-Chen's method both achieved close approximation driving M- θ r curves of all given connections except a few cases of Kishi-Chen model, and M u estimated by the proposed formulation is more rational than that predicted by Kishi-Chen's method.

  1. Prediction of moment-rotation characteristic of top- and seat-angle bolted connection incorporating prying action

    NASA Astrophysics Data System (ADS)

    Ahmed, Ali

    2017-02-01

    Finite element (FE) analyses were performed to explore the prying influence on moment-rotation behaviour and to locate yielding zones of top- and seat-angle connections in author's past research studies. The results of those FE analyses with experimental failure strategies of the connections were used to develop failure mechanisms of top- and seat-angle connections in the present study. Then a formulation was developed based on three simple failure mechanisms considering bending and shear deformations, effects of prying action on the top angle and stiffness of the tension bolts to estimate rationally the ultimate moment M u of the connection, which is a vital parameter of the proposed four-parameter power model. Applicability of the proposed formulation is assessed by comparing moment-rotation (M-θ r ) curves and ultimate moment capacities with those measured by experiments and estimated by FE analyses and three-parameter power model. This study shows that proposed formulation and Kishi-Chen's method both achieved close approximation driving M-θ r curves of all given connections except a few cases of Kishi-Chen model, and M u estimated by the proposed formulation is more rational than that predicted by Kishi-Chen's method.

  2. Complications of the tunnel-graft procedure for attachment of a hairpiece: a review of 100 cases.

    PubMed

    Bendl, B J

    1977-01-01

    The office procedure of creating tunnel grafts for attachment of hairpieces is not without complications. Early complications such as a hematoma under a graft, bacterial infection, and maceration of the epithelium lining the tunnels tended to be acute, but minor. Late complications, such as cutting in of the clips into the roofs of tunnels or stretching of the tunnel-graft roof, were mainly of a mechanical nature. Recommendations for reducing the indicence of such complications are made.

  3. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... and approval of project planning and design documents submitted by the Self-Governance Tribe? 137.365... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Roles of the...-Governance Tribe? (a) The Secretary shall review and approve planning documents to ensure compliance...

  4. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and approval of project planning and design documents submitted by the Self-Governance Tribe? 137.365... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Roles of the...-Governance Tribe? (a) The Secretary shall review and approve planning documents to ensure compliance...

  5. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... and approval of project planning and design documents submitted by the Self-Governance Tribe? 137.365... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Roles of the...-Governance Tribe? (a) The Secretary shall review and approve planning documents to ensure compliance...

  6. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and approval of project planning and design documents submitted by the Self-Governance Tribe? 137.365... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Roles of the...-Governance Tribe? (a) The Secretary shall review and approve planning documents to ensure compliance...

  7. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and approval of project planning and design documents submitted by the Self-Governance Tribe? 137.365... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Roles of the...-Governance Tribe? (a) The Secretary shall review and approve planning documents to ensure compliance...

  8. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC... and Approving Abandonment under Section 7 of the Natural Gas Act, as Amended, Concerning Any...

  9. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC... and Approving Abandonment under Section 7 of the Natural Gas Act, as Amended, Concerning Any...

  10. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC... and Approving Abandonment under Section 7 of the Natural Gas Act, as Amended, Concerning Any...

  11. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC... and Approving Abandonment under Section 7 of the Natural Gas Act, as Amended, Concerning Any...

  12. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Federal Register, legal notice in one or more newspapers of general circulation, or press release. The.... This may include, but is not limited to, legal notice in a newspaper of general circulation or press release. The public shall have a minimum of 30 calendar days to review and comment on the proposal....

  13. 34 CFR 602.32 - Procedures for Department review of applications for recognition or for change in scope...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and evaluation panel meetings, and decision meetings take place and to one or more of the institutions or programs it accredits or preaccredits; (2) Review of the public comments and other third-party information the Department staff receives by the established deadline, and the agency's responses to the...

  14. The high risks of ventriculoperitoneal shunt procedures for hydrocephalus associated with vein of Galen malformations in childhood: case report and literature review.

    PubMed

    Jea, Andrew; Bradshaw, Tina J; Whitehead, William E; Curry, Daniel J; Dauser, Robert C; Luerssen, Thomas G

    2010-08-01

    Little to no pediatric or neurosurgical literature has been published about the complications of ventriculoperitoneal shunt procedures for hydrocephalus associated with vein of Galen malformations in childhood. The interventional neuroradiology literature, however, suggests that ventriculoperitoneal shunting as first-line treatment for hydrocephalus in children with vein of Galen malformations is fraught with short- and long-term dangers, including status epilepticus, intraventricular hemorrhage, subdural hematoma and hygroma, venous infarction, malignant dystrophic calcification, and worsening developmental delay. We present a single pediatric case where a ventriculoperitoneal shunt procedure for symptomatic hydrocephalus seemed to be the major contributing factor to the rapid neurological deterioration and eventual death of an infant with a vein of Galen malformation. Based on this experience and our review of the literature, we suggest the use of endovascular embolization of the vein of Galen malformation to reestablish a balance in hydrovenous dynamics as first-line treatment rather than directly addressing hydrocephalus with CSF diversion. The ventriculoperitoneal shunt procedure should be reserved for cases with symptomatic hydrocephalus in which the patient is a poor candidate for embolization, or for cases where endovascular therapy has already been maximized. The role of endoscopy in the treatment of hydrocephalus associated with vein of Galen malformations is not clear.

  15. Minor salivary gland biopsy in Sjögren’s syndrome: A review and introduction of a new tool to ease the procedure

    PubMed Central

    Varela-Centelles, Pablo; Seoane-Romero, Juan M.; Sánchez-Sánchez, Mariña; González-Mosquera, Antonio; Diz-Dios, Pedro

    2014-01-01

    Objectives: To review the existing techniques for minor salivary gland biopsy (MSGB) in the lip and to suggest a new approach to ease the procedure and reduce post-operative complications. Study Design: A comprehensive literature review and a descriptive study of a new surgical technique. Results: Diverse incisions have been suggested for MSGB with different designs (ellipse, circular, linear), different directions (parallel, oblique, vertical) and a wide range of lengths (from 1 mm up to 3 cm), but no comparative studies supporting the advantages of a particular type of incision over the others could be retrieved. A variety of features of the existing techniques for MSGB are linked to undesired events and surgical complications which could be minimized by modifying certain aspects of these procedures. The technique described, together with the use of the S forceps, represents a significant improvement over the already described chalazion forceps because it allows for a better access and positioning of the lower lip, improves the ergonomic conditions of the assistant, and facilitates the identification of lip areas with more superficial gland lobules. Conclusions: The suggested approach for lip MSGB includes a specifically designed instrument whose performance during lip biopsy may contribute to minimize post-operative complications. Key words:Sjögren’s syndrome, diagnosis, minor salivary gland biopsy, surgical technique, lower lip. PMID:23986014

  16. VALIDATION OF ANALYTICAL METHODS AND INSTRUMENTATION FOR BERYLLIUM MEASUREMENT: REVIEW AND SUMMARY OF AVAILABLE GUIDES, PROCEDURES, AND PROTOCOLS

    SciTech Connect

    Ekechukwu, A.

    2008-12-17

    This document proposes to provide a listing of available sources which can be used to validate analytical methods and/or instrumentation for beryllium determination. A literature review was conducted of available standard methods and publications used for method validation and/or quality control. A comprehensive listing of the articles, papers, and books reviewed is given in Appendix 1. Available validation documents and guides are listed in the appendix; each has a brief description of application and use. In the referenced sources, there are varying approaches to validation and varying descriptions of validation at different stages in method development. This discussion focuses on validation and verification of fully developed methods and instrumentation that have been offered up for use or approval by other laboratories or official consensus bodies such as ASTM International, the International Standards Organization (ISO) and the Association of Official Analytical Chemists (AOAC). This review was conducted as part of a collaborative effort to investigate and improve the state of validation for measuring beryllium in the workplace and the environment. Documents and publications from the United States and Europe are included. Unless otherwise specified, all documents were published in English.

  17. A survey of 77 major infectious complications of median sternotomy: a review of 7,949 consecutive operative procedures.

    PubMed

    Grossi, E A; Culliford, A T; Krieger, K H; Kloth, D; Press, R; Baumann, F G; Spencer, F C

    1985-09-01

    Sternal wound infections developed following 77 (0.97%) of 7,949 operative procedures involving median sternotomy at New York University Medical Center from 1976 to 1984. Risk factors associated with the development of a sternal wound infection included combined revascularization and valve replacement, early reexploration for bleeding, prolonged low cardiac output syndrome, and prolonged ventilatory support (greater than 24 hours). Concomitant infection at other sites with the same organism as cultured from the sternum was present in 42% of the patients. Thirty-seven patients (48%) were treated with radical debridement followed by closed antibiotic irrigation. In 31 other patients (40%), the wounds were debrided and left to heal by open granulation. Both initial treatments had equally high success rates (78.4% and 74.2%, respectively). However, the open granulation method resulted in a hospital stay that was an average of 10 days longer than the closed antibiotic irrigation method. Muscle flaps were used to expedite healing of open granulation in 9 patients. Analysis of the results of different treatment strategies revealed that if debridement was accomplished within 20 days of the initial cardiac procedure, 76% of the patients could be successfully treated with closed antibiotic irrigation. Conversely, if treatment was delayed for longer than 20 days, 81% of the patients were treated with open granulation (p less than 0.001). Also noted was an inverse relationship between the serum blood urea nitrogen (BUN) level and the success rate of initial treatment with closed antibiotic irrigation. Patients with a serum BUN level of less than 40 mg/dl at the time of debridement had a 90% success rate as opposed to a success rate of 38% when the BUN level was 40 mg/dl or greater. The data presented suggest the following conclusions. Early diagnosis is crucial to successful treatment of sternal wound infection. When diagnosis can be established within 20 days, 80% of

  18. Updated Lagrangian finite element formulations of various biological soft tissue non-linear material models: a comprehensive procedure and review.

    PubMed

    Townsend, Molly T; Sarigul-Klijn, Nesrin

    2016-01-01

    Simplified material models are commonly used in computational simulation of biological soft tissue as an approximation of the complicated material response and to minimize computational resources. However, the simulation of complex loadings, such as long-duration tissue swelling, necessitates complex models that are not easy to formulate. This paper strives to offer the updated Lagrangian formulation comprehensive procedure of various non-linear material models for the application of finite element analysis of biological soft tissues including a definition of the Cauchy stress and the spatial tangential stiffness. The relationships between water content, osmotic pressure, ionic concentration and the pore pressure stress of the tissue are discussed with the merits of these models and their applications.

  19. Minkowski momentum resulting from a vacuum-medium mapping procedure, and a brief review of Minkowski momentum experiments

    NASA Astrophysics Data System (ADS)

    Brevik, Iver

    2017-02-01

    A discussion is given on the interpretation and physical importance of the Minkowski momentum in macroscopic electrodynamics (essential for the Abraham-Minkowski problem). We focus on the following two facets: (1) Adopting a simple dielectric model where the refractive index n is constant, we demonstrate by means of a mapping procedure how the electromagnetic field in a medium can be mapped into a corresponding field in vacuum. This mapping was presented many years ago (Brevik and Lautrup, 1970), but is apparently not well known. A characteristic property of this procedure is that it shows how naturally the Minkowski energy-momentum tensor fits into the canonical formalism. Especially the spacelike character of the electromagnetic total four-momentum for a radiation field (implying negative electromagnetic energy in some inertial frames), so strikingly demonstrated in the Cherenkov effect, is worth attention. (2) Our second objective is to give a critical analysis of some recent experiments on electromagnetic momentum. Care must here be taken in the interpretations: it is easy to be misled and conclude that an experiment is important for the energy-momentum problem, while what is demonstrated experimentally is merely the action of the Abraham-Minkowski force acting in surface layers or inhomogeneous regions. The Abraham-Minkowski force is common for the two energy-momentum tensors and carries no information about field momentum. As a final item, we propose an experiment that might show the existence of the Abraham force at high frequencies. This would eventually be a welcome optical analogue to the classic low-frequency 1975 Lahoz-Walker experiment.

  20. To what extent are surgery and invasive procedures effective beyond a placebo response? A systematic review with meta-analysis of randomised, sham controlled trials

    PubMed Central

    Jonas, Wayne B; Crawford, Cindy; Colloca, Luana; Kaptchuk, Ted J; Moseley, Bruce; Miller, Franklin G; Kriston, Levente; Linde, Klaus; Meissner, Karin

    2015-01-01

    Objectives To assess the quantity and quality of randomised, sham-controlled studies of surgery and invasive procedures and estimate the treatment-specific and non-specific effects of those procedures. Design Systematic review and meta-analysis. Data sources We searched PubMed, EMBASE, CINAHL, CENTRAL (Cochrane Library), PILOTS, PsycInfo, DoD Biomedical Research, clinicaltrials.gov, NLM catalog and NIH Grantee Publications Database from their inception through January 2015. Study selection We included randomised controlled trials of surgery and invasive procedures that penetrated the skin or an orifice and had a parallel sham procedure for comparison. Data extraction and analysis Three authors independently extracted data and assessed risk of bias. Studies reporting continuous outcomes were pooled and the standardised mean difference (SMD) with 95% CIs was calculated using a random effects model for difference between true and sham groups. Results 55 studies (3574 patients) were identified meeting inclusion criteria; 39 provided sufficient data for inclusion in the main analysis (2902 patients). The overall SMD of the continuous primary outcome between treatment/sham-control groups was 0.34 (95% CI 0.20 to 0.49; p<0.00001; I2=67%). The SMD for surgery versus sham surgery was non-significant for pain-related conditions (n=15, SMD=0.13, p=0.08), marginally significant for studies on weight loss (n=10, SMD=0.52, p=0.05) and significant for gastroesophageal reflux disorder (GERD) studies (n=5, SMD=0.65, p<0.001) and for other conditions (n=8, SMD=0.44, p=0.004). Mean improvement in sham groups relative to active treatment was larger in pain-related conditions (78%) and obesity (71%) than in GERD (57%) and other conditions (57%), and was smaller in classical-surgery trials (21%) than in endoscopic trials (73%) and those using percutaneous procedures (64%). Conclusions The non-specific effects of surgery and other invasive procedures are generally large. Particularly in

  1. VALIDATION OF ANALYTICAL METHODS AND INSTRUMENTATION FOR BERYLLIUM MEASUREMENT: REVIEW AND SUMMARY OF AVAILABLE GUIDES, PROCEDURES, AND PROTOCOLS

    SciTech Connect

    Ekechukwu, A

    2009-05-27

    Method validation is the process of evaluating whether an analytical method is acceptable for its intended purpose. For pharmaceutical methods, guidelines from the United States Pharmacopeia (USP), International Conference on Harmonisation (ICH), and the United States Food and Drug Administration (USFDA) provide a framework for performing such valications. In general, methods for regulatory compliance must include studies on specificity, linearity, accuracy, precision, range, detection limit, quantitation limit, and robustness. Elements of these guidelines are readily adapted to the issue of validation for beryllium sampling and analysis. This document provides a listing of available sources which can be used to validate analytical methods and/or instrumentation for beryllium determination. A literature review was conducted of available standard methods and publications used for method validation and/or quality control. A comprehensive listing of the articles, papers and books reviewed is given in the Appendix. Available validation documents and guides are listed therein; each has a brief description of application and use. In the referenced sources, there are varying approches to validation and varying descriptions of the valication process at different stages in method development. This discussion focuses on valication and verification of fully developed methods and instrumentation that have been offered up for use or approval by other laboratories or official consensus bodies such as ASTM International, the International Standards Organization (ISO) and the Association of Official Analytical Chemists (AOAC). This review was conducted as part of a collaborative effort to investigate and improve the state of validation for measuring beryllium in the workplace and the environment. Documents and publications from the United States and Europe are included. Unless otherwise specified, all referenced documents were published in English.

  2. What is the influence of single-entry models on access to elective surgical procedures? A systematic review

    PubMed Central

    Damani, Zaheed; Conner-Spady, Barbara; Nash, Tina; Tom Stelfox, Henry; Noseworthy, Tom W; Marshall, Deborah A

    2017-01-01

    Background Single-entry models (SEMs) for the management of patients awaiting elective surgical services are designed to increase access and flow through the system of care. We assessed scope of use and influence of SEMs on access (waiting times/throughput) and patient-centredness (patient/provider acceptability). Methods Systematic review of articles published in 6 relevant electronic databases included studies from database inception to July 2016. Included studies needed to (1) report on the nature of the SEM; (2) specify elective service and (3) address at least 1 of 3 research questions related to (1) scope of use of SEMs; (2) influence on timeliness and access; (3) patient-centredness and acceptability. Article quality was assessed using a modified Downs and Black checklist. Results 11 studies from Canada, Australia and the UK were included with mostly weak observational design—2 simulations, 5 before–after, 2 descriptive and 2 cross-sectional studies. 9 studies showed a decrease in patient waiting times; 6 showed that more patients were meeting benchmark waiting times; and 5 demonstrated that waiting lists decreased using an SEM as compared with controls. Patient acceptability was examined in 6 studies, with high levels of satisfaction reported. Acceptability among general practitioners/surgeons was mixed, as reported in 1 study. Research varied widely in design, scope, reported outcomes and overall quality. Conclusions This is the first review to assess the influence of SEMs on access to elective surgery for adults. This review demonstrates a potential ability for SEMs to improve timeliness and patient-centredness of elective services; however, the small number of low-quality studies available does not support firm conclusions about the effectiveness of SEMs to improve access. Further evaluation with higher quality designs and rigour is required. PMID:28237954

  3. Risk factors for surgical site infection following nonshunt pediatric neurosurgery: a review of 9296 procedures from a national database and comparison with a single-center experience.

    PubMed

    Sherrod, Brandon A; Arynchyna, Anastasia A; Johnston, James M; Rozzelle, Curtis J; Blount, Jeffrey P; Oakes, W Jerry; Rocque, Brandon G

    2017-02-10

    OBJECTIVE Surgical site infection (SSI) following CSF shunt operations has been well studied, yet risk factors for nonshunt pediatric neurosurgery are less well understood. The purpose of this study was to determine SSI rates and risk factors following nonshunt pediatric neurosurgery using a nationwide patient cohort and an institutional data set specifically for better understanding SSI. METHODS The authors reviewed the American College of Surgeons National Surgical Quality Improvement Program-Pediatric (ACS NSQIP-P) database for the years 2012-2014, including all neurosurgical procedures performed on pediatric patients except CSF shunts and hematoma evacuations. SSI included deep (intracranial abscesses, meningitis, osteomyelitis, and ventriculitis) and superficial wound infections. The authors performed univariate analyses of SSI association with procedure, demographic, comorbidity, operative, and hospital variables, with subsequent multivariate logistic regression analysis to determine independent risk factors for SSI within 30 days of the index procedure. A similar analysis was performed using a detailed institutional infection database from Children's of Alabama (COA). RESULTS A total of 9296 nonshunt procedures were identified in NSQIP-P with an overall 30-day SSI rate of 2.7%. The 30-day SSI rate in the COA institutional database was similar (3.3% of 1103 procedures, p = 0.325). Postoperative time to SSI in NSQIP-P and COA was 14.6 ± 6.8 days and 14.8 ± 7.3 days, respectively (mean ± SD). Myelomeningocele (4.3% in NSQIP-P, 6.3% in COA), spine (3.5%, 4.9%), and epilepsy (3.4%, 3.1%) procedure categories had the highest SSI rates by procedure category in both NSQIP-P and COA. Independent SSI risk factors in NSQIP-P included postoperative pneumonia (OR 4.761, 95% CI 1.269-17.857, p = 0.021), immune disease/immunosuppressant use (OR 3.671, 95% CI 1.371-9.827, p = 0.010), cerebral palsy (OR 2.835, 95% CI 1.463-5.494, p = 0.002), emergency operation (OR 1

  4. Functional study of one nucleotide mutation in pri-miR-125a coding region which related to recurrent pregnancy loss.

    PubMed

    Hu, Yi; Huo, Zheng-Hao; Liu, Chun-Mei; Liu, Shi-Guo; Zhang, Ning; Yin, Kun-Lun; Qi, Lu; Ma, Xu; Xia, Hong-Fei

    2014-01-01

    MicroRNAs (miRNAs) are short non-coding RNAs which modulate gene expression by binding to complementary segments present in the 3'UTR of the mRNAs of protein coding genes. MiRNAs play very important roles in maintaining normal human body physiology conditions, meanwhile, abnormal miRNA expressions have been found related to many human diseases spanning from psychiatric disorders to malignant cancers. Recently, emerging reports have indicated that disturbed miRNAs expression contributed to the pathogenesis of recurrent pregnancy loss (RPL). In this study, we identified a new mutation site (+29A>G, position relative to pre-miR-125a) by scanning pri-miR-125a coding region in 389 Chinese Han RPL patients. This site was co-existed with two polymorphisms (rs12976445 and rs41275794) in patients heterogeneously and changed the predicted secondary structures of pri-miR-125a. Subsequent in vitro analysis indicated that the A>G mutation reduced mature miR-125a expression, and further led to less efficient inhibition of verified target genes. Functional analysis showed that mutant pri-mir-125a can enhance endometrial stromal cells (ESCs) invasive capacity and increase the sensitivity of ESCs cells to mifepristone. Moreover, we further analyzed the possible molecular mechanism by RIP-chip assay and found that mutant pri-mir-125a disturbed the expression of miR-125a targetome, the functions of which includes embryonic development, cell proliferation, migration and invasion. These data suggest that A>G mutation in pri-miR-125a coding region contributes to the genetic predisposition to RPL by disordering the production of miR-125a, which consequently meddled in gene regulatory network between mir-125a and mRNA.

  5. The use of nanoparticles in polymeric and ceramic membrane structures: review of manufacturing procedures and performance improvement for water treatment.

    PubMed

    Kim, Jeonghwan; Van der Bruggen, Bart

    2010-07-01

    Membrane separations are powerful tools for various applications, including wastewater treatment and the removal of contaminants from drinking water. The performance of membranes is mainly limited by material properties. Recently, successful attempts have been made to add nanoparticles or nanotubes to polymers in membrane synthesis, with particle sizes ranging from 4 nm up to 100 nm. Ceramic membranes have been fabricated with catalytic nanoparticles for synergistic effects on the membrane performance. Breakthrough effects that have been reported in the field of water and wastewater treatment include fouling mitigation, improvement of permeate quality and flux enhancement. Nanomaterials that have been used include titania, alumina, silica, silver and many others. This paper reviews the role of engineered nanomaterials in (pressure driven) membrane technology for water treatment, to be applied in drinking water production and wastewater recycling. Benefits and drawbacks are described, which should be taken into account in further studies on potential risks related to release of nanoparticles into the environment.

  6. Endoscopic ultrasound guided drainage of pancreatic fluid collections: Assessment of the procedure, technical details and review of the literature

    PubMed Central

    Puri, Rajesh; Thandassery, Ragesh Babu; Alfadda, Abdulrahman A; Kaabi, Saad Al

    2015-01-01

    Endoscopic ultrasound (EUS) guided drainage of pancreatic fluid collections (PFC) has become increasingly popular and become first line management option in many centers. Use of therapeutic echoendoscopes has greatly increased the applicability of EUS guided transmural drainage. Drainage is indicated in symptomatic PFCs, PFC related infection, bleed, luminal obstruction, fistulization and biliary obstruction. EUS guided transmural drainage of PFCs is preferred in patients with non bulging lesions, portal hypertension, bleeding tendency and in those whom conventional drainage has failed. In the present decade significant progress has been made in minimally invasive endoscopic techniques. There are newer stent designs, access devices and techniques for more efficient drainage of PFCs. In this review, we discuss the EUS guided drainage of PFCs in acute pancreatitis. PMID:25901214

  7. Endoscopic ultrasound guided drainage of pancreatic fluid collections: Assessment of the procedure, technical details and review of the literature.

    PubMed

    Puri, Rajesh; Thandassery, Ragesh Babu; Alfadda, Abdulrahman A; Kaabi, Saad Al

    2015-04-16

    Endoscopic ultrasound (EUS) guided drainage of pancreatic fluid collections (PFC) has become increasingly popular and become first line management option in many centers. Use of therapeutic echoendoscopes has greatly increased the applicability of EUS guided transmural drainage. Drainage is indicated in symptomatic PFCs, PFC related infection, bleed, luminal obstruction, fistulization and biliary obstruction. EUS guided transmural drainage of PFCs is preferred in patients with non bulging lesions, portal hypertension, bleeding tendency and in those whom conventional drainage has failed. In the present decade significant progress has been made in minimally invasive endoscopic techniques. There are newer stent designs, access devices and techniques for more efficient drainage of PFCs. In this review, we discuss the EUS guided drainage of PFCs in acute pancreatitis.

  8. A systematic review with procedural assessments and meta-analysis of Low Level Laser Therapy in lateral elbow tendinopathy (tennis elbow)

    PubMed Central

    Bjordal, Jan M; Lopes-Martins, Rodrigo AB; Joensen, Jon; Couppe, Christian; Ljunggren, Anne E; Stergioulas, Apostolos; Johnson, Mark I

    2008-01-01

    Background Recent reviews have indicated that low level level laser therapy (LLLT) is ineffective in lateral elbow tendinopathy (LET) without assessing validity of treatment procedures and doses or the influence of prior steroid injections. Methods Systematic review with meta-analysis, with primary outcome measures of pain relief and/or global improvement and subgroup analyses of methodological quality, wavelengths and treatment procedures. Results 18 randomised placebo-controlled trials (RCTs) were identified with 13 RCTs (730 patients) meeting the criteria for meta-analysis. 12 RCTs satisfied half or more of the methodological criteria. Publication bias was detected by Egger's graphical test, which showed a negative direction of bias. Ten of the trials included patients with poor prognosis caused by failed steroid injections or other treatment failures, or long symptom duration or severe baseline pain. The weighted mean difference (WMD) for pain relief was 10.2 mm [95% CI: 3.0 to 17.5] and the RR for global improvement was 1.36 [1.16 to 1.60]. Trials which targeted acupuncture points reported negative results, as did trials with wavelengths 820, 830 and 1064 nm. In a subgroup of five trials with 904 nm lasers and one trial with 632 nm wavelength where the lateral elbow tendon insertions were directly irradiated, WMD for pain relief was 17.2 mm [95% CI: 8.5 to 25.9] and 14.0 mm [95% CI: 7.4 to 20.6] respectively, while RR for global pain improvement was only reported for 904 nm at 1.53 [95% CI: 1.28 to 1.83]. LLLT doses in this subgroup ranged between 0.5 and 7.2 Joules. Secondary outcome measures of painfree grip strength, pain pressure threshold, sick leave and follow-up data from 3 to 8 weeks after the end of treatment, showed consistently significant results in favour of the same LLLT subgroup (p < 0.02). No serious side-effects were reported. Conclusion LLLT administered with optimal doses of 904 nm and possibly 632 nm wavelengths directly to the lateral

  9. Use of the 4F Roesch Inferior Mesenteric Catheter in Embolization Procedures in the Pelvis: A Review of 300 Cases

    SciTech Connect

    Kroencke, Thomas J. Kluner, Claudia; Hamm, Bernd; Gauruder-Burmester, Annett

    2007-04-15

    The aim of this study is to evaluate the use of a 4F Roesch inferior mesenteric (RIM) catheter for pelvic embolization procedures. Between October 2000 and January 2006, 364 patients (357 female, 7 male; age: 23-67 years) underwent embolization of various pathologies [uterine fibroids (n = 324), pure adenomyosis of the uterus (n = 19), postpartum hemorrhage (n =1), traumatic or postoperative hemorrhage (n = 9), bleeding related to cervical cancer (n =7), AV malformation of the uterus (n = 2) and high-flow priapism (n = 2)] at a single institution. In all cases, bilateral catheterization was primarily attempted with the use of a 4F hook-shaped braided endhole catheter (Roesch-Inferior-Mesenteric, RIM-Catheter, Cordis, Miami, FL). Frequency of initial failure to catheterize the vascular territory of interest and carry out the embolization were recorded and the types of difficulty encountered were noted. Catherization of the main stem of the vessel territory of interest with the use of a unilateral femoral approach and the 4F RIM catherer was successful in 334/364 (91.8%) the embolization cases. Bilateral catheterization of the internal iliac arteries using a single common femoral artery access and the 4F RIM catheter was achieved in 322/364 (88.5%) patients. In 12/364 (3.3%) patients, a contralateral puncture was performed and the same 4F catheter was used. In 28/364 (7.7%) cases the 4F RIM catheter was exchanged for a catheter with a cobra-shaped or sidewinder configuration. The 4F RIM catheter is a simple and valuable alternative to catheters and techniques commonly employed for pelvic artery embolization.

  10. Prevention of contrast-induced acute kidney injury in patients undergoing cardiovascular procedures-a systematic review and network meta-analysis

    PubMed Central

    Navarese, Eliano P.; Gurbel, Paul A.; Andreotti, Felicita; Kołodziejczak, Michalina Marta; Palmer, Suetonia C.; Dias, Sofia; Buffon, Antonino; Kubica, Jacek; Kowalewski, Mariusz; Jadczyk, Tomasz; Laskiewicz, Michał; Jędrzejek, Marek; Brockmeyer, Maximillian; Airoldi, Flavio; Ruospo, Marinella; De Servi, Stefano; Wojakowski, Wojciech; O’ Connor, Christopher; Strippoli, Giovanni F. M.

    2017-01-01

    Background Interventional diagnostic and therapeutic procedures requiring intravascular iodinated contrast steadily increase patient exposure to the risks of contrast-induced acute kidney injury (CIAKI), which is associated with death, nonfatal cardiovascular events, and prolonged hospitalization. The aim of this study was to investigate the efficacy of pharmacological and non-pharmacological treatments for CIAKI prevention in patients undergoing cardiovascular invasive procedures with iodinated contrast. Methods and findings MEDLINE, Google Scholar, EMBASE and Cochrane databases as well as abstracts and presentations from major cardiovascular and nephrology meetings were searched, up to 22 April 2016. Eligible studies were randomized trials comparing strategies to prevent CIAKI (alone or in combination) when added to saline versus each other, saline, placebo, or no treatment in patients undergoing cardiovascular invasive procedures with administration of iodinated contrast. Two reviewers independently extracted trial-level data including number of patients, duration of follow-up, and outcomes. Eighteen strategies aimed at CIAKI prevention were identified. The primary outcome was the occurrence of CIAKI. Secondary outcomes were mortality, myocardial infarction, dialysis and heart failure. The data were pooled using network meta-analysis. Treatment estimates were calculated as odds ratios (ORs) with 95% credible intervals (CrI). 147 RCTs involving 33,463 patients were eligible. Saline plus N-acetylcysteine (OR 0.72, 95%CrI 0.57–0.88), ascorbic acid (0.59, 0.34–0.95), sodium bicarbonate plus N-acetylcysteine (0.59, 0.36–0.89), probucol (0.42, 0.15–0.91), methylxanthines (0.39, 0.20–0.66), statin (0.36, 0.21–0.59), device-guided matched hydration (0.35, 0.12–0.79), prostaglandins (0.26, 0.08–0.62) and trimetazidine (0.26, 0.09–0.59) were associated with lower odds of CIAKI compared to saline. Methylxanthines (0.12, 0.01–0.94) or left ventricular

  11. Does the use of an intramedullary nail alter the duration of external fixation and rate of consolidation in tibial lengthening procedures? A systematic review.

    PubMed

    Jain, S; Harwood, P

    2012-11-01

    We performed this systematic review to evaluate tibial lengthening procedures with the use of an intramedullary nail. We investigated the hypothesis that lengthening over a nail can reduce the time spent in an external fixator and increase the rate of consolidation thereby reducing the risk of complications and improving patient satisfaction. We conducted a comprehensive literature search using the MEDLINE, EMBASE and PubMed databases using the key words 'tibia' or 'tibial lengthening' and 'nail'. This search was performed in December 2011 and repeated by both authors. Specific outcome measures were the duration of external fixation, rate of consolidation and complication rates. A total of 6 comparative studies published between 2005 and 2011 consisting of 494 procedures met our inclusion and exclusion criteria and were eligible for critical appraisal. The methodological quality of the studies was variable, and they were not homogenous enough for meta-analysis. Patients who have tibial lengthening over an intramedullary nail spend significantly less time in an external fixator. However, there is no reliable evidence to suggest that the rates of consolidation or complication are any different to those lengthened without an intramedullary nail.

  12. Procedural pediatric dermatology.

    PubMed

    Metz, Brandie J

    2013-04-01

    Due to many factors, including parental anxiety, a child's inability to understand the necessity of a procedure and a child's unwillingness to cooperate, it can be much more challenging to perform dermatologic procedures in children. This article reviews pre-procedural preparation of patients and parents, techniques for minimizing injection-related pain and optimal timing of surgical intervention. The risks and benefits of general anesthesia in the setting of pediatric dermatologic procedures are discussed. Additionally, the surgical approach to a few specific types of birthmarks is addressed.

  13. Measures and procedures utilized to determine the added value of microprocessor-controlled prosthetic knee joints: a systematic review

    PubMed Central

    2013-01-01

    Background The effectiveness of microprocessor-controlled prosthetic knee joints (MPKs) has been assessed using a variety of outcome measures in a variety of health and health-related domains. However, if the patient is to receive a prosthetic knee joint that enables him to function optimally in daily life, it is vital that the clinician has adequate information about the effects of that particular component on all aspects of persons’ functioning. Especially information concerning activities and participation is of high importance, as this component of functioning closely describes the person’s ability to function with the prosthesis in daily life. The present study aimed to review the outcome measures that have been utilized to assess the effects of microprocessor-controlled prosthetic knee joints (MPK), in comparison with mechanically controlled prosthetic knee joints, and aimed to classify these measures according to the components and categories of functioning defined by the International Classification of Functioning, Disability and Health (ICF). Subsequently, the gaps in the scientific evidence regarding the effectiveness of MPKs were determined. Methods A systematic literature search in 6 databases (i.e. PubMed, CINAHL, Cochrane Library, Embase, Medline and PsychInfo) identified scientific studies that compared the effects of using MPKs with mechanically controlled prosthetic knee joints on persons’ functioning. The outcome measures that have been utilized in those studies were extracted and categorized according to the ICF framework. Also, a descriptive analysis regarding all studies has been performed. Results A total of 37 studies and 72 outcome measures have been identified. The majority (67%) of the outcome measures that described the effects of using an MPK on persons’ actual performance with the prosthesis covered the ICF body functions component. Only 31% of the measures on persons’ actual performance investigated how an MPK may affect

  14. pri-miR-34b/c rs4938723 polymorphism is associated with hepatocellular carcinoma risk: a case-control study in a Chinese population

    PubMed Central

    Liu, Chun-Jia; Ma, Xue-Wei; Zhang, Xue-Jun; Shen, Shi-Qiang

    2017-01-01

    Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. miR-34 induces changes of its downstream genes, and plays a key role in altering the apoptotic cycle and pathways of downstream cells, and finally influences the development of cancer. We assessed the relationship of the pri-miR-34b/c rs4938723 polymorphism with hepatocellular carcinoma risk in a Chinese population. During the period of January 2014 and December 2015, a total of 164 HCC patients and 305 healthy controls were recruited from the Inner Mongolia People’s Hospital. Genotyping of the pri-miR-34b/c rs4938723 was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Using χ2 test, we observed that HCC patients were likely to have a habit of alcohol consumption (χ2 = 10.24, P = 0.001) and infect with HBV or HCV (χ2 = 128.17, P < 0.001). In co-dominant model, the CC genotype of pri-miR-34b/c rs4938723 had a significant higher risk of HCC as compared with the TT genotype, and the corresponding adjusted OR (95% CI) was 4.14 (1.91-9.75). In dominant model, we observed that the TC+CC genotype were associated with an increased risk of HCC in comparison to the TT genotype (OR = 1.67, 95% CI = 1.17-2.55). In recessive model, the CC genotype was correlated with an elevated risk of HCC when compared with the TT+TC genotype (OR = 3.46, 95% CI = 1.62-8.54). The pri-miR-34b/c rs4938723 polymorphism was associated with a higher risk of HCC in the Chinese population examined. Further large-scale and multi-center studies are required to confirm these results. PMID:28337312

  15. Zeaxanthin-independent energy quenching and alternative electron sinks cause a decoupling of the relationship between the photochemical reflectance index (PRI) and photosynthesis in an evergreen conifer during spring.

    PubMed

    Fréchette, Emmanuelle; Wong, Christopher Y S; Junker, Laura Verena; Chang, Christine Yao-Yun; Ensminger, Ingo

    2015-12-01

    In evergreen conifers, the winter down-regulation of photosynthesis and its recovery during spring are the result of a reorganization of the chloroplast and adjustments of energy-quenching mechanisms. These phenological changes may remain undetected by remote sensing, as conifers retain green foliage during periods of photosynthetic down-regulation. The aim was to assess if the timing of the spring recovery of photosynthesis and energy-quenching characteristics are accurately monitored by the photochemical reflectance index (PRI) in the evergreen conifer Pinus strobus. The recovery of photosynthesis was studied using chlorophyll fluorescence, leaf gas exchange, leaf spectral reflectance, and photosynthetic pigment measurements. To assess if climate change might affect the recovery of photosynthesis, seedlings were exposed to cold spring conditions or warm spring conditions with elevated temperature. An early spring decoupling of the relationship between photosynthesis and PRI in both treatments was observed. This was caused by differences between the timing of the recovery of photosynthesis and the timing of carotenoid and chlorophyll pool size adjustments which are the main factors controlling PRI during spring. It was also demonstrated that zeaxanthin-independent NPQ mechanisms undetected by PRI further contributed to the early spring decoupling of the PRI-LUE relationship. An important mechanism undetected by PRI seems to involve increased electron transport around photosystem I, which was a significant energy sink during the entire spring transition, particularly in needles exposed to a combination of high light and cold temperatures.

  16. Comparative efficacy of new interfaces for intra-procedural imaging review: the Microsoft Kinect, Hillcrest Labs Loop Pointer, and the Apple iPad.

    PubMed

    Chao, Cherng; Tan, Justin; Castillo, Edward M; Zawaideh, Mazen; Roberts, Anne C; Kinney, Thomas B

    2014-08-01

    We adapted and evaluated the Microsoft Kinect (touchless interface), Hillcrest Labs Loop Pointer (gyroscopic mouse), and the Apple iPad (multi-touch tablet) for intra-procedural imaging review efficacy in a simulation using MIM Software DICOM viewers. Using each device, 29 radiologists executed five basic interactions to complete the overall task of measuring an 8.1-cm hepatic lesion: scroll, window, zoom, pan, and measure. For each interaction, participants assessed the devices on a 3-point subjective scale (3 = highest usability score). The five individual scores were summed to calculate a subjective composite usability score (max 15 points). Overall task time to completion was recorded. Each user also assessed each device for its potential to jeopardize a sterile field. The composite usability scores were as follows: Kinect 9.9 (out of 15.0; SD = 2.8), Loop Pointer 12.9 (SD = 13.5), and iPad 13.5 (SD = 1.8). Mean task completion times were as follows: Kinect 156.7 s (SD = 86.5), Loop Pointer 51.5 s (SD = 30.6), and iPad 41.1 s (SD = 25.3). The mean hepatic lesion measurements were as follows: Kinect was 7.3 cm (SD = 0.9), Loop Pointer 7.8 cm (SD = 1.1), and iPad 8.2 cm (SD = 1.2). The mean deviations from true hepatic lesion measurement were as follows: Kinect 1.0 cm and for both the Loop Pointer and iPad, 0.9 cm (SD = 0.7). The Kinect had the least and iPad had the most subjective concern for compromising the sterile field. A new intra-operative imaging review interface may be near. Most surveyed foresee these devices as useful in procedures, and most do not anticipate problems with a sterile field. An ideal device would combine iPad's usability and accuracy with the Kinect's touchless aspect.

  17. Reviews

    NASA Astrophysics Data System (ADS)

    2003-07-01

    CD REVIEWS (346) Spectrum 7 Physics - Waves SOFTWARE REVIEW (347) Sound Packages BOOK REVIEW (350) Measured Tones, 2nd edition WEB WATCH (351) What’s the frequency, Kenneth? BOOK REVIEW (354) We know what you did last summer ... now do something better this summer

  18. Reviews

    NASA Astrophysics Data System (ADS)

    2001-07-01

    A-LEVEL RESOURCES REVIEWS SPECIAL AS and A2 books and resources: deciding what to buy? SUMMARY Exam boards, specifications and support materials OCR (Oxford Cambridge and RSA Examinations) CORRECTION BOOK REVIEW Good Practice in Science Teaching WEB WATCH Astronomy and cosmology DVD REVIEW The Video Encyclopedia of Physics Demonstrations SOFTWARE REVIEW Graph Paper Printer

  19. Radical nephroureterectomy versus endoscopic procedures for the treatment of localised upper tract urothelial carcinoma: a meta-analysis and a systematic review of current evidence from comparative studies.

    PubMed

    Yakoubi, R; Colin, P; Seisen, T; Léon, P; Nison, L; Bozzini, G; Shariat, S F; Rouprêt, M

    2014-12-01

    The conservative management of upper tract urothelial carcinoma (UTUC) has seen important developments over the last 10 years with advances in endoscopy. Our aim was to compare the available evidence regarding the impact of endoscopic nephron sparing procedures (NSP) and radical nephroureterectomy (RNU) on survival of upper tract urothelial carcinoma (UTUC). A critical review of Pubmed/Medline, Embase and the Cochrane Central Register of Controlled Trials was performed in July 2013 according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. Overall, eight publications were selected for inclusion in this meta-analysis but all of them were retrospective or non-randomised comparative studies. The primary end points were the overall and cancer-specific survivals (OS and CSS) in the two treatment groups. We achieved to pool data on 1002 patients diagnosed with localised UTUC and treated either by endoscopic NSP (n = 322) or by RNU (n = 680). No significant difference was found in terms of OS and CSS between RNU and endoscopic NSP (HR = 1.47 and p = 0.31; HR = 0.96 and p = 0.91, respectively). However, the low level of evidence (3b) and the heterogeneity of the studies limited the quality of the results. In the absence of prospective and randomised studies, the equivalent oncologic control for endoscopic NSP and RNU is not provided by this meta-analysis. Multicentre prospective studies are urgently needed to assess the oncologic outcomes of UTUC with endoscopic management. In the next multicentre studies, the patients should be matched on the basis of the tumour stage (imaging) and grade (biopsy) at diagnosis.

  20. Transverse resistance in Y1-yPryBa2Cu3O7-δ at large praseodymium concentrations

    NASA Astrophysics Data System (ADS)

    Vovk, Ruslan V.; Khadzhai, Georgij Ya.; Dobrovolskiy, Oleksandr V.

    2014-10-01

    The effect of praseodymium doping on the transverse electrical resistance of Y1-yPryBa2Cu3O7-δ single crystals is investigated by electrical resistance measurements. The resistance curves can be fitted well to an expression accounting for the thermo-activated variable-range hopping charge transfer in conjunction with the fluctuation conductivity in the 3D Aslamazov-Larkin model. Our analysis of the Pr concentration dependence of the fitting parameters shows that in the concentration range 0.34

  1. Magnetic and electric behavior of praseodymium substituted CuPryFe2-yO4 ferrites

    NASA Astrophysics Data System (ADS)

    Farid, Muhammad Tahir; Ahmad, Ishtiaq; Kanwal, Muddassara; Murtaza, Ghulam; Ali, Irshad; Ashiq, Muhammad Naeem; Khan, Sajjad Ahmad

    2017-01-01

    Spinel ferrites with chemical formula CuPryFe2-yO4(y=0.0,0.02,0.04,0.06,0.08,0.10) were synthesized using sol-gel technique. The sintered powder characterized by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and vibrating sample magnetometer (VSM). X-ray Diffraction analysis showed that the samples with concentration (y=0.0-0.06) have single spinel phase and the samples with concentration at y=0.08-0.10 have secondary phase (ortho ferrite phase) along spinel phase. The Lattice constant a increased with the substitution of Praseodymium (Pr) ions. The crystallite size calculated from Scherre's formula is found in the range of 53-37 nm. It is observed that DC resistivity and activation energy enhances with the substitution of Pr. The dc resistivity decreased with the increase in temperature. The conduction below Curie temperature (Tc) is due to hopping of electrons and holes, whereas, above Curie temperature it is due to polaron hopping. The decrease in Tc with increasing Pr constant may be due to the fact that Pr-Fe interactions on the B sites are weaker than Fe-Fe interaction. The saturation magnetization (Ms) and remanence (Mr) decreased where as coercivity (Hc) has been increased with the increase of Pr content. The measured parameters suggest that these materials are potential candidates for high frequency applications.

  2. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure for hepatocellular carcinoma with chronic liver disease: a case report and review of literature

    PubMed Central

    Pizanias, Michail; Yip, Vincent; Prassas, Evangellos; Prachalias, Andreas; Quaglia, Alberto; Peddu, Praveen; Heaton, Nigel; Srinivasan, Parthi

    2016-01-01

    The incidence of complications after liver resection is closely related to functional future liver remnant (FLR). The standard approach to augment FLR is surgical or radiological occlusion of the artery or portal vein on the tumor side. Associated liver partition and portal vein ligation for staged hepatectomy (ALLPS) has been introduced as an alternative method to augment FLR. It offers rapid and effective hypertrophy for resecting liver metastases. However, data regarding its application in patients with hepatocellular carcinoma (HCC) with a background of chronic liver disease are limited. Here we describe the use of ALPPS procedure to manage a large solitary HCC with a background of chronic liver disease. The rising incidence of HCC has increased the number of surgical resections in patients with advanced stage liver disease not considered for liver transplantation. We reviewed reported experience of ALPPS in established chronic liver disease and current therapeutic modalities for HCC on a background of chronic liver disease in patients with potential liver insufficiency where tumor burden is beyond liver transplant criteria. PMID:27212995

  3. Educational Accounting Procedures.

    ERIC Educational Resources Information Center

    Tidwell, Sam B.

    This chapter of "Principles of School Business Management" reviews the functions, procedures, and reports with which school business officials must be familiar in order to interpret and make decisions regarding the school district's financial position. Among the accounting functions discussed are financial management, internal auditing,…

  4. Pediatric Procedural Pain

    ERIC Educational Resources Information Center

    Blount, Ronald L.; Piira, Tiina; Cohen, Lindsey L.; Cheng, Patricia S.

    2006-01-01

    This article reviews the various settings in which infants, children, and adolescents experience pain during acute medical procedures and issues related to referral of children to pain management teams. In addition, self-report, reports by others, physiological monitoring, and direct observation methods of assessment of pain and related constructs…

  5. Reviews

    ERIC Educational Resources Information Center

    Schodde, P.; Ed.

    1976-01-01

    Reviews 17 books and curriculum materials of interest to secondary science teachers. Topics include plant science, pollution, fishes, science investigations, general zoology, neurobiology, electronics, and the environment. (MLH)

  6. Zeaxanthin-independent energy quenching and alternative electron sinks cause a decoupling of the relationship between the photochemical reflectance index (PRI) and photosynthesis in an evergreen conifer during spring

    PubMed Central

    Fréchette, Emmanuelle; Wong, Christopher Y. S.; Junker, Laura Verena; Chang, Christine Yao-Yun; Ensminger, Ingo

    2015-01-01

    In evergreen conifers, the winter down-regulation of photosynthesis and its recovery during spring are the result of a reorganization of the chloroplast and adjustments of energy-quenching mechanisms. These phenological changes may remain undetected by remote sensing, as conifers retain green foliage during periods of photosynthetic down-regulation. The aim was to assess if the timing of the spring recovery of photosynthesis and energy-quenching characteristics are accurately monitored by the photochemical reflectance index (PRI) in the evergreen conifer Pinus strobus. The recovery of photosynthesis was studied using chlorophyll fluorescence, leaf gas exchange, leaf spectral reflectance, and photosynthetic pigment measurements. To assess if climate change might affect the recovery of photosynthesis, seedlings were exposed to cold spring conditions or warm spring conditions with elevated temperature. An early spring decoupling of the relationship between photosynthesis and PRI in both treatments was observed. This was caused by differences between the timing of the recovery of photosynthesis and the timing of carotenoid and chlorophyll pool size adjustments which are the main factors controlling PRI during spring. It was also demonstrated that zeaxanthin-independent NPQ mechanisms undetected by PRI further contributed to the early spring decoupling of the PRI–LUE relationship. An important mechanism undetected by PRI seems to involve increased electron transport around photosystem I, which was a significant energy sink during the entire spring transition, particularly in needles exposed to a combination of high light and cold temperatures. PMID:26386258

  7. Minimally invasive procedures

    PubMed Central

    Baltayiannis, Nikolaos; Michail, Chandrinos; Lazaridis, George; Anagnostopoulos, Dimitrios; Baka, Sofia; Mpoukovinas, Ioannis; Karavasilis, Vasilis; Lampaki, Sofia; Papaiwannou, Antonis; Karavergou, Anastasia; Kioumis, Ioannis; Pitsiou, Georgia; Katsikogiannis, Nikolaos; Tsakiridis, Kosmas; Rapti, Aggeliki; Trakada, Georgia; Zissimopoulos, Athanasios; Zarogoulidis, Konstantinos

    2015-01-01

    Minimally invasive procedures, which include laparoscopic surgery, use state-of-the-art technology to reduce the damage to human tissue when performing surgery. Minimally invasive procedures require small “ports” from which the surgeon inserts thin tubes called trocars. Carbon dioxide gas may be used to inflate the area, creating a space between the internal organs and the skin. Then a miniature camera (usually a laparoscope or endoscope) is placed through one of the trocars so the surgical team can view the procedure as a magnified image on video monitors in the operating room. Specialized equipment is inserted through the trocars based on the type of surgery. There are some advanced minimally invasive surgical procedures that can be performed almost exclusively through a single point of entry—meaning only one small incision, like the “uniport” video-assisted thoracoscopic surgery (VATS). Not only do these procedures usually provide equivalent outcomes to traditional “open” surgery (which sometimes require a large incision), but minimally invasive procedures (using small incisions) may offer significant benefits as well: (I) faster recovery; (II) the patient remains for less days hospitalized; (III) less scarring and (IV) less pain. In our current mini review we will present the minimally invasive procedures for thoracic surgery. PMID:25861610

  8. Reviews

    NASA Astrophysics Data System (ADS)

    2002-09-01

    CD-ROM REVIEWS (449) It's Physics Furry Elephant: Electricity Explained BOOK REVIEWS (450) What Are the Chances? Voodoo Deaths, Office Gossip and Other Adventures in Probability Dictionary of Mechanics: A handbook for teachers and students Intermediate 2 Physics PLACES TO VISIT (452) Spaceguard Centre WEB WATCH (455) Risk

  9. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1988

    1988-01-01

    Reviews three computer software packages for Apple II computers. Includes "Simulation of Hemoglobin Function,""Solution Equilibrium Problems," and "Thin-Layer Chromatography." Contains ratings of ease of use, subject matter content, pedagogic value, and student reaction according to two separate reviewers for each…

  10. Procedures in the 1st year of life for children with trisomy 13 and trisomy 18, a 25-year, single-center review.

    PubMed

    Josephsen, Justin B; Armbrecht, Eric S; Braddock, Stephen R; Cibulskis, Catherine C

    2016-09-01

    Care of the child born with trisomy 13 or 18 has evolved over the past few decades, leading to increased healthcare utilization. We hypothesized that there has been an increase in procedures across all intensity types, including major, invasive procedures. We performed a retrospective-cohort study of children with trisomy 13 or 18 from 1990 to 2014 in a quaternary, free-standing children's hospital. Children were identified using ICD-9 billing diagnoses. Procedures were identified during these encounters and categorized by intensity (major, intermediate, or minor). One hundred thirty-two children with trisomy 13 or 18 were identified. In children with trisomy 13, major procedures increased from period 1 (1990-1997) to period 3 (2006-2013) from 0.11 to 0.78 procedures per patient. For trisomy 18, the increase between the time periods was from 0.14 to 1.33 procedures per patient. By the end of the study period, nearly all trisomy 13 patients had a major procedure and the majority of those with trisomy 18 had undergone a major procedure. Estimated 1-year survival for those with a major procedure was 30% and 22% for trisomies 13 and 18, respectively. In conclusion, there was an increasing rate of procedures per patient of all intensity levels over the 25-year study period. Given differences in characteristics in those with trisomies 13 and 18, and effects of intervention on survival, an individualized approach to care of these patients should be employed by parents and healthcare providers, using factors such as trisomy type, infant gender, co-morbidities, and parental preference. © 2016 Wiley Periodicals, Inc.

  11. Conductivity of single-crystal Y1-yPryBa2Cu3O7-δ over a wide range of temperatures and Pr concentrations

    NASA Astrophysics Data System (ADS)

    Khadzhai, G. Ya.; Vovk, N. R.; Vovk, R. V.

    2014-06-01

    The in-plane electrical resistance of Y1-yPryBa2Cu3O7-δ single crystals with a high degree of perfection is studied for temperatures in the range TC-300 K, where TC ranges from 92 to 52 K, with varying praseodymium content. The experimental data are approximated by an expression that takes electron scattering on phonons and defects into account, as well as fluctuation conductivity in a 3D Aslamazov-Larkin model. According to the approximation data the Debye temperature ranges from 350-370 K, depending on the praseodymium content. The transverse coherence length is ˜1 Å.

  12. Experimental oxygen potentials for U1-yPryO2±x and thermodynamic assessment of the U-Pr-O system

    NASA Astrophysics Data System (ADS)

    McMurray, J. W.; Silva, C. M.

    2016-03-01

    Thermogravimetric analysis (TGA) was used to determine the oxygen potentials of fluorite urania-praseodymia (U1-yPryO2±x) solid solutions for y = 0.10 and 0.20 between 1000 and 1500 °C. A thermodynamic assessment of U-Pr-O system was performed using the CALPHAD (CALculation of PHAse Diagrams) method. The models well reproduce the TGA measurements and the computed phase relations are in good agreement with those proposed from an X-ray diffraction investigation.

  13. Experimental oxygen potentials of U1-yPryO2± x and thermodynamic assessment of the U-Pr-O system

    DOE PAGES

    McMurray, Jake W.; Silva, Chinthaka M.

    2015-12-09

    Thermogravimetric analysis (TGA) was used to determine the oxygen potentials of fluorite urania-praseodymia (U1-yPryO2± x) solid solutions for y = 0.10 and 0.20 between 1000 and 1500 °C. A thermodynamic assessment of U-Pr-O system was performed using the CALPHAD (CALculation of PHAse Diagrams) method. Furthermore, the models well reproduce the TGA measurements and the computed phase relations are in good agreement with those proposed from an X-ray diffraction investigation.

  14. Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk.

    PubMed

    Yuan, Fang; Sun, Ruifen; Chen, Peng; Liang, Yundan; Ni, Shanshan; Quan, Yi; Huang, Juan; Zhang, Lin; Gao, Linbo

    2016-05-01

    miR-34 family members can form a p53-miR-34 positive feedback loop and induce apoptosis, DNA repair, angiogenesis, and cell cycle arrest. We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women. Genotypes of the two polymorphisms in 328 cervical cancer patients and 568 control subjects were determined by using a polymerase chain reaction-restriction fragment length polymorphism assay. We found a significantly increased cervical cancer risk in the pri-miR-34b/c rs4938723 under dominant and overdominant model (CT/CC vs. TT: adjusted OR = 1.34, 95 % CI = 1.01-1.77; CT vs. TT/CC: adjusted OR = 1.37, 95 % CI = 1.05-1.80, respectively). Increased cervical cancer risks were also found in the TP53 Arg72Pro under a heterozygous comparison and overdominant model (CG vs. GG: adjusted OR = 1.44, 95 % CI = 1.06-1.95; CG vs. GG/CC: adjusted OR = 1.47, 95 % CI = 1.12-1.94, respectively). Stratification analysis showed that patients carrying the pri-miR-34b/c rs4938723 CT genotype had a significantly increased risk for developing poorly differential status and clinical stage I. Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis. Combined analysis revealed that the genotypes of rs4938723 CT/CC and TP53 Arg72Pro CG/CC had an increased cervical cancer risk (OR = 2.21, 95 % CI = 1.38-3.53). These findings suggest that the pri-miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms may contribute to the genesis of cervical cancer.

  15. Oculoplastic procedures

    MedlinePlus

    ... lights of the surgical room. Self Care at Home Your recovery will depend on your condition and ... people are able to return to work and social activities about 2 weeks after surgery. The amount ... WA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla ...

  16. 40 CFR 154.34 - Expedited procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Expedited procedures. 154.34 Section 154.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS SPECIAL REVIEW PROCEDURES Procedures § 154.34 Expedited procedures. (a) The Agency may elect to issue...

  17. 40 CFR 154.34 - Expedited procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Expedited procedures. 154.34 Section 154.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS SPECIAL REVIEW PROCEDURES Procedures § 154.34 Expedited procedures. (a) The Agency may elect to issue...

  18. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1988

    1988-01-01

    Reviews four software packages available for IBM PC or Apple II. Includes "Graphical Analysis III"; "Space Max: Space Station Construction Simulation"; "Guesstimation"; and "Genetic Engineering Toolbox." Focuses on each packages' strengths in a high school context. (CW)

  19. Reviews.

    ERIC Educational Resources Information Center

    Greenleaf, Floyd; And Others

    1986-01-01

    Reviews eight textbooks, readers, and books. Topics include Latin America, colonial America, the Carolinians, women in French textbooks, the Vikings, the Soviet Union, nineteenth-century Black America, and Ernest Rutherford. (TRS)

  20. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1990

    1990-01-01

    Reviewed are two computer software packages: "Introduction to Spectroscopy, IR, NMR & CMR," and "ASYSTANT" (a mathematical and statistical analysis software tool). Discussed are the functions, strengths, weaknesses, hardware requirements, components, level, and cost for each package. (CW)

  1. Reviews.

    ERIC Educational Resources Information Center

    Radcliffe, George; And Others

    1988-01-01

    Reviews three software packages: 1) a package containing 68 programs covering general topics in chemistry; 2) a package dealing with acid-base titration curves and allows for variables to be changed; 3) a chemistry tutorial and drill package. (MVL)

  2. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1987

    1987-01-01

    Provides a review of both the Apple and IBM versions of ENZPACK, a software package which is designed to assist in the teaching of enzyme kinetics in courses where this topic is treated in some depth. (TW)

  3. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1987

    1987-01-01

    Provides reviews of four computer software packages designed for use in science education. Describes courseware dealing with a variety of tips for teaching physics concepts, chemical reactions in an aqueous solution, mitosis and meiosis, and photosynthesis. (TW)

  4. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1989

    1989-01-01

    Reviews seven software programs: (1) "Science Baseball: Biology" (testing a variety of topics); (2) "Wildways: Understanding Wildlife Conservation"; (3) "Earth Science Computer Test Bank"; (4) "Biology Computer Test Bank"; (5) "Computer Play & Learn Series" (a series of drill and test…

  5. Documenting Laboratory Procedures with Video

    PubMed Central

    Wyttenbach, Robert A.

    2015-01-01

    Demonstrating laboratory procedures in person during class time can be time-consuming. When procedures are done under a microscope, live demonstration is also impractical because of the limited number of students who can view the demonstration at once. Creating videos beforehand, which students can watch before class and review during lab sessions, solves both of these problems. This article suggests ways to make and distribute high quality video of microscopic procedures. PMID:26240520

  6. Intranasal ethmoidectomy and concurrent procedures.

    PubMed

    Taylor, J S; Crocker, P V; Keebler, J S

    1982-07-01

    In this review of 526 intranasal ethmoidectomy procedures, there was a complication rate of 2.5% with no blindness, meningitis, or deaths. The rationale for associated concurrent procedures is presented. The use of an absorbable hemostatic sinus sponge and an easily removable Telfa nasal packing made possible just a two-night hospital stay in over 90% of these patients.

  7. 42 CFR 137.297 - If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... agency's policies and procedures meet the requirements of NEPA, NHPA, and related environmental laws? 137... meet the requirements of NEPA, NHPA, and related environmental laws? No, the Federal agency is... environmental laws, not the Self-Governance Tribe....

  8. 42 CFR 137.297 - If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... agency's policies and procedures meet the requirements of NEPA, NHPA, and related environmental laws? 137... meet the requirements of NEPA, NHPA, and related environmental laws? No, the Federal agency is... environmental laws, not the Self-Governance Tribe....

  9. 42 CFR 137.297 - If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... agency's policies and procedures meet the requirements of NEPA, NHPA, and related environmental laws? 137... meet the requirements of NEPA, NHPA, and related environmental laws? No, the Federal agency is... environmental laws, not the Self-Governance Tribe....

  10. 42 CFR 137.297 - If the environmental review procedures of a Federal agency are adopted by a Self-Governance Tribe...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... agency's policies and procedures meet the requirements of NEPA, NHPA, and related environmental laws? 137... meet the requirements of NEPA, NHPA, and related environmental laws? No, the Federal agency is... environmental laws, not the Self-Governance Tribe....

  11. Reviews.

    ERIC Educational Resources Information Center

    Repak, Arthur J.; And Others

    1988-01-01

    Computer software, audiovisuals, and books are reviewed. Includes topics on interfacing, ionic equilibrium, space, the classification system, Acquired Immune Disease Syndrome, evolution, human body processes, energy, pesticides, teaching school, cells, and geological aspects. Availability, price, and a description of each are provided. (RT)

  12. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1988

    1988-01-01

    Reviews two computer programs: "Molecular Graphics," which allows molecule manipulation in three-dimensional space (requiring IBM PC with 512K, EGA monitor, and math coprocessor); and "Periodic Law," a database which contains up to 20 items of information on each of the first 103 elements (Apple II or IBM PC). (MVL)

  13. Reviews

    NASA Astrophysics Data System (ADS)

    2003-05-01

    DISTANCE-LEARNING COURSES (263) Planetary Science and Astronomy BOOK REVIEWS (263) A New Kind of Science Planetary Science: The Science of Planets Around Stars EQUIPMENT (265) The Science Enhancement Program (SEP) Geiger Counter WEB WATCH (265) Revision sites SOFTWARE (267) Exploration of Physics Volume 1

  14. Reviews.

    ERIC Educational Resources Information Center

    Newland, Robert J.; And Others

    1988-01-01

    Reviews four organic chemistry computer programs and three books. Software includes: (1) NMR Simulator 7--for IBM or Macintosh, (2) Nucleic Acid Structure and Synthesis--for IBM, (3) Molecular Design Editor--for Apple II, and (4) Synthetic Adventure--for Apple II and IBM. Book topics include physical chemistry, polymer pioneers, and the basics of…

  15. Reviews.

    ERIC Educational Resources Information Center

    Wu, Jennifer L.; And Others

    1996-01-01

    Reviews multicultural books under the subject categories of history, biography, social sciences, reference, juvenile works, and nonprint materials, with subcategories where appropriate (for example, age-group categories for children's books). Thesaurus citations in the author index indicate relevant ethnic groups, races, religions, and geographic…

  16. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1989

    1989-01-01

    Reviews a software planetarium package called "Sky Travel." Includes two audiovisuals: "Conquest of Space" and "Windows on Science: Earth Science"; and four books: "Small Energy Sources: Choices that Work,""Stonehenge Complete,""Uneasy Careers and Intimate Lives: Women in Science…

  17. Reviews.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1988

    1988-01-01

    Reviews three computer software packages for chemistry education including "Osmosis and Diffusion" and "E.M.E. Titration Lab" for Apple II and "Simplex-V: An Interactive Computer Program for Experimental Optimization" for IBM PC. Summary ratings include ease of use, content, pedagogic value, student reaction, and…

  18. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1988

    1988-01-01

    Presents information and concerns regarding computer courseware, books, and audiovisual materials reviewed by teachers. Covers a variety of topics including dissection of common classroom specimens, medicine, acid rain projects, molecules, the water cycle, erosion, plankton, and evolution. Notes on availability, price, and needed equipment, where…

  19. National Ignition Facility (NIF) operations procedures plan

    SciTech Connect

    Mantrom, D.

    1998-05-06

    The purpose of this Operations Procedures Plan is to establish a standard procedure which outlines how NIF Operations procedures will be developed (i.e , written, edited, reviewed, approved, published, revised) and accessed by the NIF Operations staff who must use procedures in order to accomplish their tasks. In addition, this Plan is designed to provide a guide to the NIF Project staff to assist them in planning and writing procedures. Also, resource and scheduling information is provided.

  20. Procedural learning and dyslexia.

    PubMed

    Nicolson, R I; Fawcett, A J; Brookes, R L; Needle, J

    2010-08-01

    Three major 'neural systems', specialized for different types of information processing, are the sensory, declarative, and procedural systems. It has been proposed (Trends Neurosci., 30(4), 135-141) that dyslexia may be attributable to impaired function in the procedural system together with intact declarative function. We provide a brief overview of the increasing evidence relating to the hypothesis, noting that the framework involves two main claims: first that 'neural systems' provides a productive level of description avoiding the underspecificity of cognitive descriptions and the overspecificity of brain structural accounts; and second that a distinctive feature of procedural learning is its extended time course, covering from minutes to months. In this article, we focus on the second claim. Three studies-speeded single word reading, long-term response learning, and overnight skill consolidation-are reviewed which together provide clear evidence of difficulties in procedural learning for individuals with dyslexia, even when the tasks are outside the literacy domain. The educational implications of the results are then discussed, and in particular the potential difficulties that impaired overnight procedural consolidation would entail. It is proposed that response to intervention could be better predicted if diagnostic tests on the different forms of learning were first undertaken.