Science.gov

Sample records for reviewing procedure pri

  1. Cloze Procedure. An Historical Review.

    ERIC Educational Resources Information Center

    Wardell, David

    Cloze procedure, a testing method which systematically deletes words in written prose and then measures the accuracy of the information is reviewed from a historical viewpoint. Redundancy is placed in a verbal context and can be noted on three separate levels of language: (1) surface syntactic structure; (2) deep syntactic structure; and (3)…

  2. 36 CFR 908.32 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Review procedures. 908.32... DEVELOPMENT AREA Review Procedure § 908.32 Review procedures. (a) Upon receipt of a request for review, the... applicable regulations; (2) Information submitted by the applicant including the request for review and...

  3. Procedures for Peer Review of Grant Applications

    ERIC Educational Resources Information Center

    US Department of Education, 2006

    2006-01-01

    This guide presents information on the procedures for peer review of grant applications. It begins with an overview of the review process for grant application submission and review. The review process includes: (1) pre-submission procedures that enable the Institute to plan for specific review sessions; (2) application processing procedures; (3)…

  4. 36 CFR 908.32 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Review procedures. 908.32... DEVELOPMENT AREA Review Procedure § 908.32 Review procedures. (a) Upon receipt of a request for review, the... applicable regulations; (2) Information submitted by the applicant including the request for review and...

  5. 19 CFR 351.221 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Review procedures. 351.221 Section 351.221 Customs... Antidumping and Countervailing Duty Procedures § 351.221 Review procedures. (a) Introduction. The procedures for reviews are similar to those followed in investigations. This section details the...

  6. 49 CFR 601.47 - Review Procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Review Procedures. 601.47 Section 601.47 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for Public Transportation Systems § 601.47 Review Procedures....

  7. PriMux

    2010-08-31

    PriMux is used to compute sets of compatible Polymerase Chain Reaction (PCR)signatures that can be used for detecting the presence of biological species in a small sample of material. Before use, the computed signatures must be empirically tested in a wet lab.

  8. 42 CFR 431.812 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Review procedures. 431.812 Section 431.812 Public... Eligibility Quality Control (meqc) Program § 431.812 Review procedures. (a) Active case reviews. (1) Except as provided in paragraph (a)(2) of this section, the agency must review all active cases selected from...

  9. 12 CFR 1408.10 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Review procedures. 1408.10 Section 1408.10... Administrative Collection of Claims § 1408.10 Review procedures. (a) Unless an oral hearing is required by § 1408.23(d), the Corporation's review shall be a review of the written record of the claim. (b) If an...

  10. 16 CFR 260.4 - Review procedure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Review procedure. 260.4 Section 260.4... ENVIRONMENTAL MARKETING CLAIMS § 260.4 Review procedure. The Commission will review the guides as part of its... of a claim or regarding substantiation of a claim. Following review of such a petition,...

  11. 12 CFR 608.810 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Review procedures. 608.810 Section 608.810... UNITED STATES Administrative Collection of Claims § 608.810 Review procedures. (a) Unless an oral hearing is required by § 608.823(d), the FCA's review shall be a review of the written record of the...

  12. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  13. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  14. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  15. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  16. 39 CFR 776.9 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Review procedures. 776.9 Section 776.9 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending...

  17. 49 CFR 211.47 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Review procedures. 211.47 Section 211.47..., DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE Emergency Orders § 211.47 Review procedures. (a) As specified in section 203, Public Law 91-458, 84 Stat. 972 (45 U.S.C. 432), opportunity for review of...

  18. 49 CFR 211.47 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Review procedures. 211.47 Section 211.47..., DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE Emergency Orders § 211.47 Review procedures. (a) As specified in section 203, Public Law 91-458, 84 Stat. 972 (45 U.S.C. 432), opportunity for review of...

  19. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Review procedures. 142.80 Section 142...) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  20. 33 CFR 331.7 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Review procedures. 331.7 Section... DEFENSE ADMINISTRATIVE APPEAL PROCESS § 331.7 Review procedures. (a) General. The administrative appeal... permits. Upon receipt of an RFA, the RO shall review the RFA to determine whether the RFA is acceptable...

  1. 40 CFR 142.80 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Review procedures. 142.80 Section 142...) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Administrator's Review of State Decisions that Implement Criteria Under Which Filtration Is Required § 142.80 Review procedures. (a) The Administrator...

  2. 49 CFR 601.47 - Review Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Review Procedures. 601.47 Section 601.47 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  3. 49 CFR 601.47 - Review Procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Review Procedures. 601.47 Section 601.47 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  4. 49 CFR 601.47 - Review Procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Review Procedures. 601.47 Section 601.47 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  5. 49 CFR 601.47 - Review Procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Review Procedures. 601.47 Section 601.47 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  6. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  7. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  8. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  9. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  10. 39 CFR 776.5 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.5 Review procedures. Officials shall follow the decision-making process outlined in paragraphs (a) through (f) of this section, when a facility action may involve floodplain...

  11. Reviewing practice procedure can improve bottom line.

    PubMed

    Gambill, C

    1998-01-01

    Anecdotal and statistical sources attest that many hospital-owned physician practices are either losing money or breaking even. This is alarming for not only hospital-owned practices, but stand-alone practices, too. However, careful review of standard billing and coding practice procedures and policies, among other things, can help reverse that trend. PMID:10181639

  12. Reviewing the College Disciplinary Procedure. Mendip Papers.

    ERIC Educational Resources Information Center

    Kedney, R. J.; Saunders, R.

    This paper provides practical advice on reviewing and designing disciplinary procedures and is set in the context of incorporation of further education and sixth form colleges in England. Reasons are provided for having disciplinary rules, based on the Advisory Conciliation and Arbitration Service's (ACAS) Code of Practice. Relevant English…

  13. 12 CFR 797.9 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... appendix A to 5 CFR part 581 to arrange for a hearing official. When NCUA is the creditor agency and the... the paying agency designated in appendix A to 5 CFR part 581 to arrange for a hearing official. The... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Review procedures. 797.9 Section 797.9...

  14. Year 2000 TWRS Maintenance procedure review report

    SciTech Connect

    ADAMS, M.R.

    1999-02-24

    A concern exists that some equipment in use might contain microprocessors that are dependent upon a time date function. The majority of the software programming for microprocessors has only utilized a 2 digit identifier for the year. With the approach of the year 2000, (Y2K), there is concern that the date function will not be correctly recognized and some functions will not operate properly. TWRS maintenance procedures have been reviewed to identify equipment components that may not be Y2K compliant. Engineering judgment was utilized to eliminate procedures and equipment that is obviously not impacted by Y2K.

  15. A review of minimally invasive cosmetic procedures.

    PubMed

    Ogden, S; Griffiths, T W

    2008-11-01

    In today's society the desire to maintain a youthful appearance has driven the development of minimally invasive dermatological procedures that are designed to rejuvenate the ageing face. The aim of this review is to present evidence for the use of techniques which can easily be incorporated into outpatient dermatology practice with low overhead expenditure. For this reason, laser and light-based treatments have been omitted. This review will instead focus on chemical peels, intradermal fillers and botulinum toxin. These techniques address the main aspects of facial ageing, namely photodamage, volume loss and dynamic lines, which correlate anatomically to skin, subcutaneous fat and muscle. A combination of such techniques will provide the practitioner with a reasonable portfolio of treatments for a balanced, holistic result.

  16. [Mood induction procedures: a critical review].

    PubMed

    Gilet, A-L

    2008-06-01

    For a long period in the history of psychological research, emotion and cognition have been studied independently, as if one were irrelevant to the other. The renewed interest of researchers for the study of the relations between cognition and emotion has led to the development of a range of laboratory methods for inducing temporary mood states. This paper aims to review the main mood induction procedures allowing the induction of a negative mood as well as a positive mood, developed since the pioneer study of Schachter and Singer [Psychol Rev 69 (1962) 379-399] and to account for the usefulness and problems related to the use of such techniques. The first part of this paper deals with the detailed presentation of some of the most popular mood induction procedures according to their type: simple (use of only one mood induction technique) or combined (association of two or more techniques at once). The earliest of the modern techniques is the Velten Mood Induction Procedure [Behav Res Ther 6 (1968) 473-482], which involves reading aloud sixty self-referent statements progressing from relative neutral mood to negative mood or dysphoria. Some researchers have varied the procedure slightly by changing the number of the statements [Behav Res Ther 21 (1983) 233-239, Br J Clin Psychol 21 (1982) 111-117, J Pers Soc Psychol 35 (1977) 625-636]. Various other mood induction procedures have been developed including music induction [Cogn Emotion 11 (1997) 403-432, Br J Med Psychol 55 (1982) 127-138], film clip induction [J Pers Soc Psychol 20 (1971) 37-43, Cogn Emotion 7 (1993) 171-193, Rottenberg J, Ray RR, Gross JJ. Emotion elicitation using films. In: Coan JA, Allen JJB, editors. The handbook of emotion elicitation and assessment. New York: Oxford University Press, 2007], autobiographical recall [J Clin Psychol 36 (1980) 215-226, Jallais C. Effets des humeurs positives et négatives sur les structures de connaissances de type script. Thèse de doctorat non publi

  17. MISR Browse Images: Puerto Rico Dust Experiment (PRiDE)

    Atmospheric Science Data Center

    2013-04-02

    MISR Browse Images: Puerto Rico Dust Experiment (PRiDE) These MISR Browse images provide ... overview of the region observed during the Puerto Rico Dust Experiment (PRiDE) field campaign. PRiDE was a study of the radiative, ...

  18. 10 CFR 10.24 - Procedures for hearing and review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Procedures for hearing and review. 10.24 Section 10.24 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.24 Procedures...

  19. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  20. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  1. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  2. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  3. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false CMS reviewing official procedure. 405.1834 Section... Determinations and Appeals § 405.1834 CMS reviewing official procedure. (a) Scope. A provider that is a party to... Administrator by a designated CMS reviewing official who considers whether the decision of the...

  4. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Review procedures. 13.303... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at...

  5. 22 CFR 61.7 - Review and appeal procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any...

  6. 42 CFR 431.980 - Eligibility review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Estimating Improper Payments in Medicaid and CHIP § 431.980 Eligibility review procedures. (a) Active case reviews. The agency must verify eligibility for all selected active cases for Medicaid and CHIP for the... must review all selected negative cases for Medicaid and CHIP for the review month to determine...

  7. 75 FR 15689 - Streamlined Procedure for Appeal Brief Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... United States Patent and Trademark Office Streamlined Procedure for Appeal Brief Review AGENCY: United... Trademark Office (USPTO) is streamlining the procedure for the review of appeal briefs to increase the efficiency of the appeal process and reduce pendency of appeals. The Chief Judge of the Board of...

  8. Procedures for Peer Review of Reports

    ERIC Educational Resources Information Center

    US Department of Education, 2006

    2006-01-01

    Under the Education Sciences Reform Act, all research, statistics, and evaluation reports conducted by, or supported through, the Institute shall be subject to rigorous peer review before being published or otherwise made available to the public. Prior to review and approval by the NCEE Commissioner, NCEE reports are reviewed internally by the…

  9. 48 CFR 242.7203 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to be reviewed. In addition, they must— (1) Conduct reviews as a team effort. (i) the ACO— (A) Appoints a team leader; and (B) Ensures that the team includes appropriate functional specialists (e.g., industrial specialist, engineer, property administrator, auditor). (ii) The team leader— (A) Advises the...

  10. 42 CFR 431.812 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) of this section. (vi) Provide a statistically valid error rate that can be projected to the universe...) Substitution of PERM data. (1) A State in its Payment Error Rate Measurement (PERM) year may elect to substitute the random sample of selected cases, eligibility review findings, and payment review...

  11. 42 CFR 431.812 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) of this section. (vi) Provide a statistically valid error rate that can be projected to the universe...) Substitution of PERM data. (1) A State in its Payment Error Rate Measurement (PERM) year may elect to substitute the random sample of selected cases, eligibility review findings, and payment review...

  12. Program Review/Evaluation Policy and Procedures.

    ERIC Educational Resources Information Center

    Colorado Northwestern Community Coll., Rangely.

    At Colorado Northwestern Community College (CNCC), all educational programs, as well as student services and support functions, are formally reviewed/evaluated in depth at least once every five years. This nine-part outline, providing a step-by-step description of the program review process at CNCC, includes the following sections: (1) the value…

  13. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  14. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  15. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  16. 48 CFR 13.303-6 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Review procedures. (a) The contracting officer placing orders under a BPA, or the designated representative of the contracting officer, shall review a sufficient random sample of the BPA files at least... into the BPA shall— (1) Ensure that each BPA is reviewed at least annually and, if necessary,...

  17. Report of the Project on Contracting, Review, and Assessment Procedures.

    ERIC Educational Resources Information Center

    Vermont Community Colleges, Montpelier.

    The broad purpose of this project was to examine all aspects of the Community College of Vermont (CCV) review and contracting process and to recommend changes to the CCV Review Board and Decision Team for implementation. Examination focused on the present program, the contract format, Local Review Committee procedures, the counseling process, and…

  18. 7 CFR 28.66 - Review procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Reviews § 28.66...

  19. 42 CFR 431.812 - Review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... section. (vi) Provide a statistically valid error rate that can be projected to the universe that is being... under review on the appropriate forms. (f) Substitution of PERM data. (1) A State in its Payment Error Rate Measurement (PERM) year may elect to substitute the random sample of selected cases,...

  20. Procedural and Conceptual Knowledge: Adults Reviewing Fractions

    ERIC Educational Resources Information Center

    Baker, William J.; Czarnocha, Bronislaw; Dias, Olen; Doyle, Kathleen; Kennis, James R.

    2012-01-01

    In the United States a majority of the students who enroll in community colleges require a review of secondary math before they are eligible for college level mathematics. In the pre-algebra course, that has a high drop-out rate, the most difficult topic for students is fractions. In order to better understand the fraction concept, Kieren…

  1. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Science Foundation and the National Institute of Mental Health. In addition to specifying substantive and procedural matters related to the peer review process, the “Guideline” addresses such...

  2. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... National Science Foundation and the National Institute of Mental Health. In addition to specifying substantive and procedural matters related to the peer review process, the “Guideline” addresses such...

  3. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Science Foundation and the National Institute of Mental Health. In addition to specifying substantive and procedural matters related to the peer review process, the “Guideline” addresses such...

  4. 28 CFR 34.102 - Peer review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... National Science Foundation and the National Institute of Mental Health. In addition to specifying substantive and procedural matters related to the peer review process, the “Guideline” addresses such...

  5. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES §...

  6. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES §...

  7. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES §...

  8. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES §...

  9. 36 CFR 215.18 - Formal review and disposition procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Formal review and disposition procedures. 215.18 Section 215.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE NOTICE, COMMENT, AND APPEAL PROCEDURES FOR NATIONAL FOREST SYSTEM PROJECTS AND ACTIVITIES §...

  10. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES GENERAL § 1355.33 Procedures for the review. (a) The full child and family services reviews will: (1) Consist of a two-phase process...

  11. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval... the types of information required. (See 40 CFR § 1506.5 (a) and (b).) (b) Upon submission by a...

  12. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval... the types of information required. (See 40 CFR § 1506.5 (a) and (b).) (b) Upon submission by a...

  13. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval... the types of information required. (See 40 CFR § 1506.5 (a) and (b).) (b) Upon submission by a...

  14. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Review/Approval Procedures § 923.60 Review/approval... the types of information required. (See 40 CFR § 1506.5 (a) and (b).) (b) Upon submission by a...

  15. Binding of two PriA-PriB complexes to the primosome assembly site initiates primosome formation.

    PubMed

    Szymanski, Michal R; Jezewska, Maria J; Bujalowski, Wlodzimierz

    2011-08-01

    A direct quantitative analysis of the initial steps in primosome assembly, involving PriA and PriB proteins and the minimal primosome assembly site (PAS) of phage ϕX174, has been performed using fluorescence intensity, fluorescence anisotropy titration, and fluorescence resonance energy transfer techniques. We show that two PriA molecules bind to the PAS at both strong and weak binding sites on the DNA, respectively, without detectable cooperative interactions. Binding of the PriB dimer to the PriA-PAS complex dramatically increases PriA's affinity for the strong site, but only slightly affects its affinity for the weak site. Associations with the strong and weak sites are driven by apparent entropy changes, with binding to the strong site accompanied by a large unfavorable enthalpy change. The PriA-PriB complex, formed independently of the DNA, is able to directly recognize the PAS without the preceding the binding of PriA to the PAS. Thus, the high-affinity state of PriA for PAS is generated through PriA-PriB interactions. The effect of PriB is specific for PriA-PAS association, but not for PriA-double-stranded DNA or PriA-single-stranded DNA interactions. Only complexes containing two PriA molecules can generate a profound change in the PAS structure in the presence of ATP. The obtained results provide a quantitative framework for the elucidation of further steps in primosome assembly and for quantitative analyses of other molecular machines of cellular metabolism.

  16. 76 FR 4933 - Environmental Review Procedures for Entities Assuming HUD Environmental Review Responsibilities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... Responsibilities; Notice of Proposed Information Collection: Comment Request AGENCY: Office of the Assistant...: Environmental Review Procedures for Entities Assuming HUD Environmental Responsibilities. OMB Control...

  17. DnaT is a PriC-binding protein.

    PubMed

    Huang, Chien-Chih; Huang, Cheng-Yang

    2016-09-01

    DnaT and PriC are replication restart primosomal proteins required for re-initiating chromosomal DNA replication. DnaT is a component of the PriA-dependent primosome, while PriC belongs to the PriC-dependent primosome. Whether DnaT can interact with PriC is still unknown. In this study, we define a direct interaction between PriC, a key initiator protein in PriC-mediated DNA replication restart, and DnaT, a DnaB/C complex loader protein, from Klebsiella pneumoniae. In fluorescence titrations, PriC bound to single-stranded DNA with a binding-site size of approximately 9 nt. Gold nanoparticle assay showed that the solution of DnaT-PriC changed from red to purple, which indicated the protein-protein interactions due to gold nanoparticle aggregate. In addition, this DnaT-PriC complex could be co-purified by the heparin HP column. Surface plasmon resonance analysis showed that the Kd value of DnaT bound to PriC was 2.9 × 10(-8) M. These results constitute a pioneering study of the DnaT-PriC interaction and present a putative link between the two independent replication restart pathways, namely, PriA- and PriC-dependent primosome assemblies. Further research can directly focus on determining how DnaT binds to the PriC-SSB-DNA tricomplex and regulates the PriC-dependent replication restart.

  18. Deinococcus radiodurans PriA is a Pseudohelicase.

    PubMed

    Lopper, Matthew E; Boone, Jacob; Morrow, Christopher

    2015-01-01

    Reactivation of repaired DNA replication forks in bacteria is catalyzed by PriA helicase. This broadly-conserved bacterial enzyme can remodel the structure of DNA at a repaired DNA replication fork by unwinding small portions of duplex DNA to prepare the fork for replisome reloading. While PriA's helicase activity is not strictly required for cell viability in E. coli, the sequence motifs that confer helicase activity upon PriA are well-conserved among sequenced bacterial priA genes, suggesting that PriA's duplex DNA unwinding activity confers a selective advantage upon cells. However, these helicase sequence motifs are not well-conserved among priA genes from the Deinococcus-Thermus phylum. Here, we show that PriA from a highly radiation-resistant member of that phylum, Deinococcus radiodurans, lacks the ability to hydrolyze ATP and unwind duplex DNA, thus qualifying D. radiodurans PriA as a pseudohelicase. Despite the lack of helicase activity, D. radiodurans PriA has retained the DNA binding activity expected of a typical PriA helicase, and we present evidence for a physical interaction between D. radiodurans PriA and its cognate replicative helicase, DnaB. This suggests that PriA has retained a role in replisome reloading onto repaired DNA replication forks in D. radiodurans despite its lack of helicase activity.

  19. Remotely Sensing the Photochemical Reflectance Index (PRI)

    NASA Technical Reports Server (NTRS)

    Vanderbilt, Vern

    2015-01-01

    In remote sensing, the Photochemical Reflectance Index (PRI) provides insight into physiological processes occurring inside the leaves in a stand of plants. Developed by Gamon et al., (1990 and 1992), PRI evolved from laboratory measurements of the reflectance of individual leaves (Bilger et al.,1989). Yet in a remotely sensed image, a pixel measurement may include light from both reflecting and transmitting leaves. We conducted laboratory experiments comparing values of PRI based upon polarized reflectance and transmittance measurements of water and nutrient stressed leaves. We illuminated single detached leaves using a current controlled light source (Oriel model 66881) and measured the leaf weight using an analytical balance (Mettler model AE 260) and the light reflected and transmitted by the leaf during dry down using two Analytical Spectral Devices spectroradiometers. Polarizers on the incident and reflected light beams allowed us to divide the leaf reflectance into two parts: a polarized surface reflectance and a non-polarized 'leaf interior' reflectance. Our results underscore the importance when calculating PRI of removing the leaf surface reflection, which contains no information about physiological processes ongoing in the leaf interior. The results show that the leaf physiology information is in the leaf interior reflectance, not the leaf transmittance. Applied to a plant stand, these results suggest use of polarization measurements in sun-view directions that minimize the number of sunlit transmitting leaves in the sensor field of view.

  20. 15 CFR 960.6 - Review procedures for license applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Review procedures for license applications. 960.6 Section 960.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA...

  1. 15 CFR 960.6 - Review procedures for license applications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Review procedures for license applications. 960.6 Section 960.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA...

  2. 15 CFR 960.6 - Review procedures for license applications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Review procedures for license applications. 960.6 Section 960.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA...

  3. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract publication review procedures. 1552.237-70 Section 1552.237-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions...

  4. 15 CFR 960.6 - Review procedures for license applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Review procedures for license applications. 960.6 Section 960.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA...

  5. 29 CFR 801.69 - Procedures for initiating review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Procedures for initiating review. 801.69 Section 801.69 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Modification...

  6. 29 CFR 801.69 - Procedures for initiating review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Procedures for initiating review. 801.69 Section 801.69 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Modification...

  7. 29 CFR 801.69 - Procedures for initiating review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Procedures for initiating review. 801.69 Section 801.69 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Modification...

  8. 29 CFR 801.69 - Procedures for initiating review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Procedures for initiating review. 801.69 Section 801.69 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Modification...

  9. 29 CFR 801.69 - Procedures for initiating review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Procedures for initiating review. 801.69 Section 801.69 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Modification...

  10. 44 CFR 8.4 - Mandatory declassification review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Mandatory declassification review procedures. 8.4 Section 8.4 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NATIONAL SECURITY INFORMATION § 8.4...

  11. 44 CFR 8.4 - Mandatory declassification review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Mandatory declassification review procedures. 8.4 Section 8.4 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NATIONAL SECURITY INFORMATION § 8.4...

  12. 33 CFR 154.1065 - Plan review and revision procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... affects the required response resources; (3) A change in the name(s) or capabilities of the oil spill... SECURITY (CONTINUED) POLLUTION FACILITIES TRANSFERRING OIL OR HAZARDOUS MATERIAL IN BULK Response Plans for Oil Facilities § 154.1065 Plan review and revision procedures. (a) A facility owner or operator...

  13. 40 CFR 501.31 - Review and approval procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Review and approval procedures. 501.31 Section 501.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STATE... sewage listed on the inventory required by § 501.12(f) of this part. The notice will: (1) Provide...

  14. 24 CFR 135.74 - Section 3 compliance review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Section 3 compliance review procedures. 135.74 Section 135.74 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF ASSISTANT SECRETARY FOR EQUAL OPPORTUNITY, DEPARTMENT OF HOUSING AND URBAN...

  15. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  16. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  17. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  18. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  19. 7 CFR 929.125 - Committee review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Committee review procedures. 929.125 Section 929.125 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES...

  20. 42 CFR 405.1834 - CMS reviewing official procedure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false CMS reviewing official procedure. 405.1834 Section 405.1834 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Provider...

  1. 44 CFR 8.4 - Mandatory declassification review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... citizen or permanent resident alien, a Federal agency or a State or local government. (b) Requests for... declassification review procedures. (a) All information classified by FEMA under E.O. 12356 or predecessor orders... shall be completed within sixty (60) calendar days. (e) The Director of the Security Division...

  2. 44 CFR 8.4 - Mandatory declassification review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... citizen or permanent resident alien, a Federal agency or a State or local government. (b) Requests for... declassification review procedures. (a) All information classified by FEMA under E.O. 12356 or predecessor orders... shall be completed within sixty (60) calendar days. (e) The Director of the Security Division...

  3. Hypnosis before diagnostic or therapeutic medical procedures: a systematic review.

    PubMed

    Cheseaux, Nicole; de Saint Lager, Alix Juillet; Walder, Bernhard

    2014-01-01

    The aim of this systematic review was to estimate the efficiency of hypnosis prior to medical procedures. Different databases were analyzed to identify randomized controlled trials (RCTs) comparing hypnosis to control interventions. All RCTs had to report pain or anxiety. Eighteen RCTs with a total of 968 patients were included; study size was from 20 to 200 patients (14 RCTs ≤ 60 patients). Fourteen RCTs included 830 adults and 4 RCTs included 138 children. Twelve of 18 RCTs had major quality limitations related to unclear allocation concealments, provider's experience in hypnosis, patient's adherence to hypnotic procedures, and intention-to-treat design. This systematic review observed major methodological limitations in RCTs on hypnosis prior to medical procedures.

  4. Review of the IEEE Standard for Computerized Operating Procedure Systems

    SciTech Connect

    O'Hara, J.; Higgins, J.

    2010-02-26

    Increasingly nuclear power plant procedures, such as emergency operating procedures, are being presented in computer form with functionality to support operator use and management of the procedures. The U.S. Nuclear Regulatory Commission (NRC) currently has guidance for the review of computer-based procedures (CBPs); however, there remain CBP functions and human performance issues for which up-to-date guidance is lacking. The Institute of Electrical and Electronics Engineers (IEEE) has initiated a standard development effort to address the human factors engineering (HFE) aspects of CBP systems. When completed, it may provide guidance to supplement the NRC staff's review criteria. The purpose of our study was to evaluate the suitability of the IEEE Standard for use in the NRC's HFE safety reviews of CBP systems and to ensure that the guidance meets the NRC's standard for scientific and engineering rigor used in its own guidance development efforts. We established the following criteria with which to evaluate the Standard: (1) it should meet an existing need of NRC reviewers, (2) it should be based in sound HFE principles, (3) it should be thoroughly peer-reviewed, and (4) it should address CBP-related human performance issues identified in the literature. This report describes the methodology we used to evaluate each criterion. Our evaluation concluded that the Standard generally does meet these criteria, however several areas were identified for which additional clarifications are needed. Thus consideration of the Standard's use by the NRC is supported. The standard evaluation methodology developed in this study can be generally applied to the review of other HFE standards being considered for possible use or endorsement by the NRC.

  5. Effectiveness of granite cleaning procedures in cultural heritage: A review.

    PubMed

    Pozo-Antonio, J S; Rivas, T; López, A J; Fiorucci, M P; Ramil, A

    2016-11-15

    Most of the Cultural Heritage built in NW Iberian Peninsula is made of granite which exposition to the environment leads to the formation of deposits and coatings, mainly two types: biological colonization and sulphated black crusts. Nowadays, another form of alteration derives from graffiti paints when these are applied as an act of vandalism. A deep revision needs to be addressed considering the severity of these deterioration forms on granite and the different cleaning effectiveness achieved by cleaning procedures used to remove them. The scientific literature about these topics on granite is scarcer than on sedimentary carbonate stones and marbles, but the importance of the granite in NW Iberian Peninsula Cultural Heritage claims this review centred on biological colonization, sulphated black crusts and graffiti on granite and their effectiveness of the common cleaning procedures. Furthermore, this paper carried out a review of the knowledge about those three alteration forms on granite, as well as bringing together all the major studies in the field of the granite cleaning with traditional procedures (chemical and mechanical) and with the recent developed technique based on the laser ablation. Findings concerning the effectiveness evaluation of these cleaning procedures, considering the coating extraction ability and the damage induced on the granite surface, are described. Finally, some futures research lines are pointed out. PMID:27443454

  6. Effectiveness of granite cleaning procedures in cultural heritage: A review.

    PubMed

    Pozo-Antonio, J S; Rivas, T; López, A J; Fiorucci, M P; Ramil, A

    2016-11-15

    Most of the Cultural Heritage built in NW Iberian Peninsula is made of granite which exposition to the environment leads to the formation of deposits and coatings, mainly two types: biological colonization and sulphated black crusts. Nowadays, another form of alteration derives from graffiti paints when these are applied as an act of vandalism. A deep revision needs to be addressed considering the severity of these deterioration forms on granite and the different cleaning effectiveness achieved by cleaning procedures used to remove them. The scientific literature about these topics on granite is scarcer than on sedimentary carbonate stones and marbles, but the importance of the granite in NW Iberian Peninsula Cultural Heritage claims this review centred on biological colonization, sulphated black crusts and graffiti on granite and their effectiveness of the common cleaning procedures. Furthermore, this paper carried out a review of the knowledge about those three alteration forms on granite, as well as bringing together all the major studies in the field of the granite cleaning with traditional procedures (chemical and mechanical) and with the recent developed technique based on the laser ablation. Findings concerning the effectiveness evaluation of these cleaning procedures, considering the coating extraction ability and the damage induced on the granite surface, are described. Finally, some futures research lines are pointed out.

  7. Review of advanced catheter technologies in radiation oncology brachytherapy procedures

    PubMed Central

    Zhou, Jun; Zamdborg, Leonid; Sebastian, Evelyn

    2015-01-01

    The development of new catheter and applicator technologies in recent years has significantly improved treatment accuracy, efficiency, and outcomes in brachytherapy. In this paper, we review these advances, focusing on the performance of catheter imaging and reconstruction techniques in brachytherapy procedures using magnetic resonance images and electromagnetic tracking. The accuracy of catheter reconstruction, imaging artifacts, and other notable properties of plastic and titanium applicators in gynecologic treatments are reviewed. The accuracy, noise performance, and limitations of electromagnetic tracking for catheter reconstruction are discussed. Several newly developed applicators for accelerated partial breast irradiation and gynecologic treatments are also reviewed. New hypofractionated high dose rate treatment schemes in prostate cancer and accelerated partial breast irradiation are presented. PMID:26203277

  8. Reconstructive procedures for treating peri-implantitis: a systematic review.

    PubMed

    Khoshkam, V; Chan, H L; Lin, G H; MacEachern, M P; Monje, A; Suarez, F; Giannobile, W V; Wang, H L

    2013-12-01

    This review aimed at evaluating the effectiveness of reconstructive procedures for treating peri-implantitis. Searches of electronic databases and cross-referencing were performed for human comparative clinical trials with ≥ 10 implants for ≥ 12 months of follow-up, reporting radiographic defect fill and at least one of the following parameters: probing depth reduction, clinical attachment level gain, bleeding on probing reduction, and mucosal recession. The searches retrieved 430 citations. Only 1 randomized controlled trial was identified, which compared reconstructive therapy and open flap debridement. Case series studies were also included to evaluate the overall performance of the reconstructive procedures. Twelve studies were finally included. Meta-analysis revealed that the weighted mean radiographic defect fill was 2.17 mm (95% confidence interval [CI]: 1.46-2.87 mm), probing depth reduction was 2.97 mm (95% CI: 2.38-3.56 mm), clinical attachment level gain was 1.65 mm (95% CI: 1.17-2.13 mm), and bleeding on probing reduction was 45.8% (95% CI: 38.5%-53.3%). Great variability in reparative outcomes was found, attributed to patient factors, defect morphology, and reconstructive agents used. Currently, there is a lack of evidence for supporting additional benefit of reconstructive procedures to the other treatment modalities for managing peri-implantitis.

  9. TOPICAL REVIEW: Image-guidance for surgical procedures

    NASA Astrophysics Data System (ADS)

    Peters, Terry M.

    2006-07-01

    Contemporary imaging modalities can now provide the surgeon with high quality three- and four-dimensional images depicting not only normal anatomy and pathology, but also vascularity and function. A key component of image-guided surgery (IGS) is the ability to register multi-modal pre-operative images to each other and to the patient. The other important component of IGS is the ability to track instruments in real time during the procedure and to display them as part of a realistic model of the operative volume. Stereoscopic, virtual- and augmented-reality techniques have been implemented to enhance the visualization and guidance process. For the most part, IGS relies on the assumption that the pre-operatively acquired images used to guide the surgery accurately represent the morphology of the tissue during the procedure. This assumption may not necessarily be valid, and so intra-operative real-time imaging using interventional MRI, ultrasound, video and electrophysiological recordings are often employed to ameliorate this situation. Although IGS is now in extensive routine clinical use in neurosurgery and is gaining ground in other surgical disciplines, there remain many drawbacks that must be overcome before it can be employed in more general minimally-invasive procedures. This review overviews the roots of IGS in neurosurgery, provides examples of its use outside the brain, discusses the infrastructure required for successful implementation of IGS approaches and outlines the challenges that must be overcome for IGS to advance further.

  10. 32 CFR 861.5 - DOD Commercial Airlift Review Board procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false DOD Commercial Airlift Review Board procedures... AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM § 861.5 DOD Commercial Airlift Review Board procedures. (a) This section establishes procedures to be used by the...

  11. 32 CFR 861.5 - DOD Commercial Airlift Review Board procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false DOD Commercial Airlift Review Board procedures... AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM § 861.5 DOD Commercial Airlift Review Board procedures. (a) This section establishes procedures to be used by the...

  12. 32 CFR 861.5 - DOD Commercial Airlift Review Board procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false DOD Commercial Airlift Review Board procedures... AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM § 861.5 DOD Commercial Airlift Review Board procedures. (a) This section establishes procedures to be used by the...

  13. PriFi: using a multiple alignment of related sequences to find primers for amplification of homologs.

    PubMed

    Fredslund, Jakob; Schauser, Leif; Madsen, Lene H; Sandal, Niels; Stougaard, Jens

    2005-07-01

    Using a comparative approach, the web program PriFi (http://cgi-www.daimi.au.dk/cgi-chili/PriFi/main) designs pairs of primers useful for PCR amplification of genomic DNA in species where prior sequence information is not available. The program works with an alignment of DNA sequences from phylogenetically related species and outputs a list of possibly degenerate primer pairs fulfilling a number of criteria, such that the primers have a maximal probability of amplifying orthologous sequences in other phylogenetically related species. Operating on a genome-wide scale, PriFi automates the first steps of a procedure for developing general markers serving as common anchor loci across species. To accommodate users with special preferences, configuration settings and criteria can be customized.

  14. A review of human drug self-administration procedures

    PubMed Central

    Jones, Jermaine D.; Comer, Sandra D.

    2014-01-01

    Drug self-administration procedures in laboratory settings allow us to closely model drug-taking behavior in real-world settings. This review provides an overview of many of the common self-administration methods used in human laboratory research. Typically, self-administration studies provide a quantifiable measure of the reinforcing effect of a drug, which is believed to be predictive of its potential for abuse. Several adaptations of the self-administration paradigm exist, the simplest of which allows participants free access to the drug under investigation. Free-access procedures allow investigators to observe patterns of drug self-administration and drug effects in a controlled setting. Allowing participants to choose between two simultaneously available reinforcers (choice procedures) is another well-established method of assessing the reinforcing effects of a drug. Offering a choice between two reinforcers (e.g. two different doses of the same drug, two different drugs, or drug and nondrug reinforcers) provides researchers with a point of comparison (e.g. between a drug of known abuse potential and a novel drug). When combined with other endpoints, such as subjective effects ratings, physiological responses, and cognitive performance, human self-administration paradigms have contributed significantly to our understanding of the factors that contribute to, maintain, and alter drug-taking behavior including: craving, positive subjective effects, toxicity, drug interactions and abstinence. This area of research has also begun to incorporate other techniques such as imaging and genetics to further understand the multifaceted nature of substance abuse. The present paper summarizes the different self-administration techniques that are commonly used today and the application of other procedures that may complement interpretation of the drug PMID:23839027

  15. Donor site morbidity after articular cartilage repair procedures: a review.

    PubMed

    Matricali, Giovanni A; Dereymaeker, Greta Ph E; Luyten, Frank P

    2010-10-01

    In order to perform an Osteochondral Autologous Transplantation (OAT) or an Autologous Chondrocyte Implantation (ACI), the integrity of healthy intact articular cartilage at a second location needs to be violated. This creates the possibility for donor site morbidity. Only recently have any publications addressed this issue. The aim of this manuscript is to review the current knowledge on donor site morbidity after an OAT or an ACI. Reports were identified by searching Medline and Pubmed up to March 2010. Donor site morbidity was described mostly considering a clinical outcome, both in a qualitative (parameters in history or physical examination) and/or quantitative way (knee status reported by means of a numerical score). An increasing rate of problems is noted when using quantitative instead of qualitative parameters, and when donor site morbidity is the focus of attention, affecting up to more than half of the patients, in particular for an OAT procedure. The decision to harvest an osteochondral or cartilage biopsy to perform a repair procedure should therefore be taken with caution. This also underscores the need for further research to identify safe donor sites or to develop techniques that eliminate the need for a formal biopsy ccompletely.

  16. 16 CFR 1021.7 - Coordination of environmental review with CPSC procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... decisionmaking process. (c) Draft EISs or findings of no significant impact together with environmental... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Coordination of environmental review with... ENVIRONMENTAL REVIEW Procedures § 1021.7 Coordination of environmental review with CPSC procedures. (a)...

  17. 16 CFR 1021.7 - Coordination of environmental review with CPSC procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... decisionmaking process. (c) Draft EISs or findings of no significant impact together with environmental... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Coordination of environmental review with... ENVIRONMENTAL REVIEW Procedures § 1021.7 Coordination of environmental review with CPSC procedures. (a)...

  18. 16 CFR 1021.7 - Coordination of environmental review with CPSC procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... decisionmaking process. (c) Draft EISs or findings of no significant impact together with environmental... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Coordination of environmental review with... ENVIRONMENTAL REVIEW Procedures § 1021.7 Coordination of environmental review with CPSC procedures. (a)...

  19. 16 CFR 1021.7 - Coordination of environmental review with CPSC procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... decisionmaking process. (c) Draft EISs or findings of no significant impact together with environmental... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Coordination of environmental review with... ENVIRONMENTAL REVIEW Procedures § 1021.7 Coordination of environmental review with CPSC procedures. (a)...

  20. 21 CFR 814.44 - Procedures for review of a PMA.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Procedures for review of a PMA. 814.44 Section 814...) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES FDA Action on a PMA § 814.44 Procedures for review of a PMA. (a) FDA will begin substantive review of a PMA after the PMA is accepted for filing...

  1. Explaining the variability of Photochemical Reflectance Index (PRI): deconvolution of variability related to Light Use Efficiency and Canopy attributes.

    NASA Astrophysics Data System (ADS)

    Merlier, Elodie; Hmimina, Gabriel; Dufrêne, Eric; Soudani, Kamel

    2014-05-01

    . 1992. A narrow-waveband spectral index that tracks diurnal changes in photosynthetic efficiency. Remote Sensing of Environment 41, 35-44. Garbulsky MF, Peñuelas J, Gamon J, Inoue Y, Filella I. 2011. The photochemical reflectance index (PRI) and the remote sensing of leaf, canopy and ecosystem radiation use efficiencies: A review and meta-analysis. Remote Sensing of Environment 115, 281-297. Hilker T, Coops NC, Hall FG, Black TA, Wulder MA, Nesic Z, Krishnan P. 2008. Separating physiologically and directionally induced changes in PRI using BRDF models. Remote Sensing of Environment 112, 2777-2788. Hmimina G, Dufrêne E, Soudani K. 2014. Relationship between PRI and leaf ecophysiological and biochemical parameters under two different water statuses: toward a rapid and efficient correction method using real-time measurements. Plant, Cell & Environment 37, 2, 473-487. Nakaji T, Oguma H, Fujinuma Y. 2006. Seasonal changes in the relationship between photochemical reflectance index and photosynthetic light use efficiency of Japanese larch needles. International Journal of Remote Sensing 27, 493-509. Rahimzadeh-Bajgiran P, Munehiro M, Omasa K. 2012. Relationships between the photochemical reflectance index (PRI) and chlorophyll fluorescence parameters and plant pigment indices at different leaf growth stages. Photosynthesis Research 113, 261-271.

  2. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... determinations and fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and...

  3. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... determinations and fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and...

  4. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... determinations and fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and...

  5. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track...

  6. 42 CFR 417.840 - Administrative review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... fast-track appeals that affect its Medicare enrollees; and (b) Reconsiderations, hearings, Medicare Appeals Council review, and judicial review of the organization determinations and fast-track...

  7. DOE EERE Standard Operating Procedure Peer Review Best Practice and Procedures

    SciTech Connect

    2009-01-18

    Objective review and advice from peers - peer review - provides managers, staff, and researchers with a powerful and effective tool for enhancing the management, relevance, effectiveness, and productivity of all of the EERE research, development

  8. Ultrasound-Guided Interventional Procedures in Pain Medicine: A Review of Anatomy, Sonoanatomy, and Procedures: Part VI: Ankle Joint.

    PubMed

    Soneji, Neilesh; Peng, Philip W H

    2016-01-01

    Ultrasound-guided injections in pain medicine are emerging as a popular technique for pain interventions. Ultrasound can be applied for procedures of the ankle joint and surrounding structures. This review describes the anatomy and sonoanatomy of the ankle joint, subtalar joint, and surrounding extra-articular structures relevant for intra-articular injection. Second, it reviews injection techniques and the accuracy and efficacy of these intra-articular ankle injections.

  9. Ethical review: Standardizing procedures and local shaping of ethical review practices.

    PubMed

    Jaspers, Patricia; Houtepen, Rob; Horstman, Klasien

    2013-12-01

    Since ethical review practice has developed in relation to specific regulatory regimes and local contexts, it cannot be understood without paying attention to the institutional context of ethical review practices. We believe the tendency towards strong central governance and standardization in ethical review implies a lack of understanding of how specific local institutional contexts actually affect ethical review practices. Our question is: "How do local institutional contexts relate to the way REC's shape their formal mandate, and what are the implications for research governance?" To get in-depth insights in how REC's shape their formal mandates in every-day practice, we did a qualitative ethnographic-sociological study of three Dutch REC's in different contexts: an academic context, a care context and a commercial context. In analyzing these three REC's we paid attention to the procedures operative in REC practices, the cultures and everyday experiences of REC members, the scientific, social and financial resources that are available to REC's, and the evaluative perspective REC's employ. We conclude that specific local, institutional contexts offer valuable resources for ethical review. To track this, insight into the institutional configuration as a whole is necessary. Variations in the ways REC's shape their formal mandate should not be regarded problematic, but rather as fruitful opportunities for public learning.

  10. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for Review of Suspension...

  11. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  12. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  13. 75 FR 29321 - Streamlined Procedure for Appeal Brief Review in Ex Parte Reexamination Proceedings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... Patent and Trademark Office Streamlined Procedure for Appeal Brief Review in Ex Parte Reexamination... States Patent and Trademark Office (USPTO) is streamlining the procedure for the review of appeal briefs in ex parte reexamination proceeding appeals to increase the efficiency of the appeal process...

  14. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Procedures for Annual Review of Base Pilotage Rates C Appendix C to Part 404 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RATEMAKING Pt. 404, App. C Appendix C to Part 404—Procedures for Annual Review of...

  15. 42 CFR 8.28 - Expedited procedures for review of immediate suspension.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Expedited procedures for review of immediate suspension. 8.28 Section 8.28 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for Review of Suspension...

  16. 42 CFR 422.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Procedures before the Departmental Appeals Board on review. 422.1080 Section 422.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Civil Money Penalties § 422.1080 Procedures before the Departmental Appeals Board on review. The...

  17. 42 CFR 422.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Procedures before the Departmental Appeals Board on review. 422.1080 Section 422.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Civil Money Penalties § 422.1080 Procedures before the Departmental Appeals Board on review. The...

  18. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and Approval for Reentry of a Reentry Vehicle § 435.33 Safety review... to the safety review conducted for a license to reenter a reentry vehicle under this part....

  19. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Reentry of a Reentry Vehicle § 435.23 Policy review... apply to the policy review conducted for a license to reenter a reentry vehicle under this part....

  20. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and Approval for Reentry of a Reentry Vehicle § 435.33 Safety review... to the safety review conducted for a license to reenter a reentry vehicle under this part....

  1. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Reentry of a Reentry Vehicle § 435.23 Policy review... apply to the policy review conducted for a license to reenter a reentry vehicle under this part....

  2. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Reentry of a Reentry Vehicle § 435.23 Policy review... apply to the policy review conducted for a license to reenter a reentry vehicle under this part....

  3. 14 CFR 435.23 - Policy review requirements and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Policy Review and Approval for Reentry of a Reentry Vehicle § 435.23 Policy review... apply to the policy review conducted for a license to reenter a reentry vehicle under this part....

  4. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and Approval for Reentry of a Reentry Vehicle § 435.33 Safety review... to the safety review conducted for a license to reenter a reentry vehicle under this part....

  5. 14 CFR 435.33 - Safety review requirements and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Safety Review and Approval for Reentry of a Reentry Vehicle § 435.33 Safety review... to the safety review conducted for a license to reenter a reentry vehicle under this part....

  6. 7 CFR 658.7 - USDA assistance with Federal agencies' reviews of policies and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... policies and procedures. 658.7 Section 658.7 Agriculture Regulations of the Department of Agriculture... PROTECTION POLICY ACT § 658.7 USDA assistance with Federal agencies' reviews of policies and procedures. (a... current provisions of law, administrative rules and regulations, and policies and procedures applicable...

  7. 7 CFR 658.7 - USDA assistance with Federal agencies' reviews of policies and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... policies and procedures. 658.7 Section 658.7 Agriculture Regulations of the Department of Agriculture... PROTECTION POLICY ACT § 658.7 USDA assistance with Federal agencies' reviews of policies and procedures. (a... current provisions of law, administrative rules and regulations, and policies and procedures applicable...

  8. 42 CFR 423.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Procedures before the Departmental Appeals Board on review. 423.1080 Section 423.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Appeal Procedures for Civil Money Penalties § 423.1080 Procedures before the Departmental Appeals...

  9. 42 CFR 423.1080 - Procedures before the Departmental Appeals Board on review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Procedures before the Departmental Appeals Board on review. 423.1080 Section 423.1080 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... Appeal Procedures for Civil Money Penalties § 423.1080 Procedures before the Departmental Appeals...

  10. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Information Act (32 CFR part 286) or Privacy Act (32 CFR part 286a) after the DD Form 293 has been submitted... matters of procedure and shall ensure that reasonable bounds of relevancy and materiality are...

  11. Procedural justice and layoff survivors' commitment: a quantitative review.

    PubMed

    Grubb, W Lee

    2006-10-01

    Layoffs are common in today's organizations. Most studies that have examined the correlation between procedural justice and the organizational commitment of layoff survivors have yielded positive correlations, but the magnitude of the correlations varies widely. This study is the first to estimate the population correlation and to identify the primary sources that cause variation in the correlation across studies. The results indicated that justice and commitment correlations can always be expected to be positive. Based on a total sample size of 9080 individuals, the estimated mean population correlation was .34. Variation was primarily explained by attributes of the justice measure where multiple items scales and scales composed of both interactional and procedural justice items yielded higher correlations than single item measures. Therefore, it is important that employers recognize the substantial assuaging affect that procedural and interactional justice can have on survivors' organizational commitment. PMID:17153823

  12. Hypnosis for Acute Procedural Pain: A Critical Review.

    PubMed

    Kendrick, Cassie; Sliwinski, Jim; Yu, Yimin; Johnson, Aimee; Fisher, William; Kekecs, Zoltán; Elkins, Gary

    2016-01-01

    Clinical evidence for the effectiveness of hypnosis in the treatment of acute procedural pain was critically evaluated based on reports from randomized controlled clinical trials (RCTs). Results from the 29 RCTs meeting inclusion criteria suggest that hypnosis decreases pain compared to standard care and attention control groups and that it is at least as effective as comparable adjunct psychological or behavioral therapies. In addition, applying hypnosis in multiple sessions prior to the day of the procedure produced the highest percentage of significant results. Hypnosis was most effective in minor surgical procedures. However, interpretations are limited by considerable risk of bias. Further studies using minimally effective control conditions and systematic control of intervention dose and timing are required to strengthen conclusions. PMID:26599994

  13. Cyclodestructive procedures. II. Optical fibers, endoscopy, physics: a review.

    PubMed

    Fankhauser, Franz; Kwasniewska, Sylwia

    2004-01-01

    Methods used in laser destructive procedures are detailed. While in noncontact procedures laser energy is delivered via the optics of a slitlamp, often enhanced by contact lenses, the contact method takes advantage of optical fibers for the delivery of energy. Endpieces such as hemispherical or microlens probes enhance the cyclodestructive effect and/or allow the dose of laser energy to be reduced. Laser energy may also be delivered under direct view by endoscopic systems. Advances in laser cyclodestruction are possible by studying the physical effects.

  14. Transcatheter Renal Interventions: A Review of Established and Emerging Procedures

    PubMed Central

    Minocha, Jeet; Parvinian, Ahmad; Bui, James T; Knuttinen, Martha Grace; Ray, Charles E; Gaba, Ron C

    2015-01-01

    Catheter-based interventions play an important role in the multidisciplinary management of renal pathology. The array of procedures available to interventional radiologists (IRs) includes established techniques such as angioplasty, stenting, embolization, thrombolysis, and thrombectomy for treatment of renovascular disease, as well as embolization of renal neoplasms and emerging therapies such as transcatheter renal artery sympathectomy for treatment of resistant hypertension. Here, we present an overview of these minimally invasive therapies, with an emphasis on interventional technique and clinical outcomes of the procedure. PMID:25806140

  15. Development of electrical test procedures for qualification of spacecraft against EID. Volume 2: Review and specification of test procedures

    NASA Technical Reports Server (NTRS)

    Wilkenfeld, J. M.; Harlacher, B. L.; Mathews, D.

    1982-01-01

    A combined experimental and analytical program to develop system electrical test procedures for the qualification of spacecraft against damage produced by space-electron-induced discharges (EID) occurring on spacecraft dielectric outer surfaces is described. A review and critical evaluation of possible approaches to qualify spacecraft against space electron-induced discharges (EID) is presented. A variety of possible schemes to simulate EID electromagnetic effects produced in spacecraft was studied. These techniques form the principal element of a provisional, recommended set of test procedures for the EID qualification spacecraft. Significant gaps in our knowledge about EID which impact the final specification of an electrical test to qualify spacecraft against EID are also identified.

  16. Applications of Self-Control Procedures by Children: A Review.

    ERIC Educational Resources Information Center

    O'Leary, Susan G.; Dubey, Dennis R.

    1979-01-01

    Particular emphasis is on self-instruction, self-determined criteria, self-assessment, and self-reinforcement. Self-punishment, comprehensive programs, and innovative self-control procedures (including distraction and restatement of contingencies) are also evaluated. (Author/DLS)

  17. Continuous monitoring, automated analysis, and sampling procedures. [Review (63 references)

    SciTech Connect

    Pitt, W.W. Jr.

    1981-06-01

    This article emphasizes the the need for a well documented quality control system in waste water monitoring and sampling procedures. The US EPA has continued its strong emphasis on effluent monitoring and has published a list of 155 organic chemicals and 23 plastic or synthetic materials industries for which it proposed to require monitoring the process waste water under the Clean Water Act. (KRM)

  18. 40 CFR 63.851 - Regulatory authority review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Primary Aluminum Reduction Plants... the owner or operator in writing of the need for additional time to review the submissions...

  19. 40 CFR 63.851 - Regulatory authority review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Primary Aluminum Reduction Plants... the owner or operator in writing of the need for additional time to review the submissions...

  20. 15 CFR 923.60 - Review/approval procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... review/approval process. The OCRM guidance also recommends a format for the program document submitted to... the types of information required. (See 40 CFR § 1506.5 (a) and (b).) (b) Upon submission by a...

  1. Finding the SurPriSe: A Case Study of a Faculty Learning Community

    ERIC Educational Resources Information Center

    Michel, Roberta M.

    2014-01-01

    This article details a faculty learning community (FLC) that started in 2009 on the campus of a Midwestern University and has evolved into an interdisciplinary research, teaching and social community of practice and learning called SurPriSe. SurPriSe is an acronym that reflects the interest area of the FLC; Sur for surveillance, Pri for privacy,…

  2. The Veterinary Forensic Necropsy: A Review of Procedures and Protocols.

    PubMed

    Brownlie, H W Brooks; Munro, R

    2016-09-01

    Investigation of animal-related crime, and therefore submission of forensic cases to veterinary pathology facilities, is increasing, yet many veterinary pathologists are unfamiliar and often uncomfortable with involvement in the forensic necropsy. This article discusses various aspects of the forensic necropsy without specific attention to any particular species group or crime. General advice is given on procedures, documentation, and recording of the examination, and the article indicates how these features may differ from those used in investigation of natural disease. It also discusses evidence management, including recordkeeping, identification of evidence, labeling of photographs, and use of standard operating procedures and protocols. Various written and visual methods for documentation of the forensic necropsy are covered, and adjunctive topics such as sample collection, assessment, and description of wounds and taphonomy are included. Cause, mechanism, and manner of death are defined, and guidance to the use of these terms is given. The aim of this article is to offer guidance on procedural aspects of the forensic necropsy that will help those developing their forensic services, contribute to standardization of the provision of forensic veterinary pathology, and build the confidence of the "uncomfortable" forensic veterinary pathologist.

  3. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... in the development of the State's CFSP required at 45 CFR 1357.15(1), courts, administrative review... Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER...

  4. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... publish, in a scientific journal, material resulting directly or indirectly from work performed under this... in a journal article which has not been subjected to EPA review: “Although the research described in....” (3) Following publication of the journal article, the Contractor shall submit five copies of...

  5. 45 CFR 1355.33 - Procedures for the review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... in the development of the State's CFSP required at 45 CFR 1357.15(1), courts, administrative review... Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER...

  6. 23 CFR 230.409 - Contract compliance review procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... on previous PR-1391's (23 CFR part 230, subpart A, appendix C) Review Reports and Hometown Plan... representation of sources; (4) The availability of minorities and females with requisite skills in a reasonable... contractor taking to meet the contractual requirement to provide equal employment opportunity? (iii) Are...

  7. 23 CFR 230.409 - Contract compliance review procedures.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... on previous PR-1391's (23 CFR part 230, subpart A, appendix C) Review Reports and Hometown Plan... representation of sources; (4) The availability of minorities and females with requisite skills in a reasonable... contractor taking to meet the contractual requirement to provide equal employment opportunity? (iii) Are...

  8. 23 CFR 230.409 - Contract compliance review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... on previous PR-1391's (23 CFR part 230, subpart A, appendix C) Review Reports and Hometown Plan... representation of sources; (4) The availability of minorities and females with requisite skills in a reasonable... contractor taking to meet the contractual requirement to provide equal employment opportunity? (iii) Are...

  9. 23 CFR 230.409 - Contract compliance review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... on previous PR-1391's (23 CFR part 230, subpart A, appendix C) Review Reports and Hometown Plan... representation of sources; (4) The availability of minorities and females with requisite skills in a reasonable... contractor taking to meet the contractual requirement to provide equal employment opportunity? (iii) Are...

  10. 23 CFR 230.409 - Contract compliance review procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... on previous PR-1391's (23 CFR part 230, subpart A, appendix C) Review Reports and Hometown Plan... held, job promoted into; and corresponding wage rates; (vii) An annotated payroll to show job... appropriate, indicating actions and reactions of the contractor, a brief synopsis of any meetings with...

  11. 28 CFR 50.6 - Antitrust Division business review procedure.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... U.S.C. 18A, and the regulations promulgated thereunder, 16 CFR, part 801. 8. After review of a... upon the requesting party's operations or relationships with actual or potential customers, employees, suppliers (including suppliers of credit), stockholders, or competitors. The Department of Justice, in...

  12. 48 CFR 1552.237-70 - Contract publication review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... publish, in a scientific journal, material resulting directly or indirectly from work performed under this... in a journal article which has not been subjected to EPA review: “Although the research described in....” (3) Following publication of the journal article, the Contractor shall submit five copies of...

  13. 19 CFR 145.22 - Procedures for obtaining administrative review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of duty assessed under a mail entry, he may obtain administrative review in the following ways: (a) He may pay the assessed duty, take delivery of the merchandise, and send a copy of the mail entry to... believed the duty assessed is incorrect. Any invoices, bills of sale, or other evidence should be...

  14. 32 CFR 70.8 - Discharge review procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Information Act (32 CFR part 286) or Privacy Act (32 CFR part 286a) after the DD Form 293 has been submitted... decisional issues based upon such questions; (C) Prevents the applicant from amending or withdrawing such matter any time before the DRB closes the review process for deliberation; or (D) Prevents the DRB...

  15. 78 FR 64234 - 30-Day Notice of Proposed Information Collection: Environmental Review Procedures for Entities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... Entities Assuming HUD Environmental Responsibilities AGENCY: Office of the Chief Information Officer, HUD... Responsibilities. OMB Approval Number: 2506-0087. Type of Request: Revision of a currently approved collection..., ``Environmental Review Procedures for Entities Assuming HUD Environmental Responsibilities'' requires units...

  16. Limiting excessive postoperative blood transfusion after cardiac procedures. A review.

    PubMed Central

    Ferraris, V A; Ferraris, S P

    1995-01-01

    Analysis of blood product use after cardiac operations reveals that a few patients (< or = 20%) consume the majority of blood products (> 80%). The risk factors that predispose a minority of patients to excessive blood use include patient-related factors, transfusion practices, drug-related causes, and procedure-related factors. Multivariate studies suggest that patient age and red blood cell volume are independent patient-related variables that predict excessive blood product transfusion after cardiac procedures. Other factors include preoperative aspirin ingestion, type of operation, over- or underutilization of heparin during cardiopulmonary bypass, failure to correct hypothermia after cardiopulmonary bypass, and physician overtransfusion. A survey of the currently available blood conservation techniques reveals 5 that stand out as reliable methods: 1) high-dose aprotinin therapy, 2) preoperative erythropoietin therapy when time permits adequate dosage before operation, 3) hemodilution by harvest of whole blood immediately before cardiopulmonary bypass, 4) autologous predonation of blood, and 5) salvage of oxygenator blood after cardiopulmonary bypass. Other methods, such as the use of epsilon-aminocaproic acid or desmopressin, cell saving devices, reinfusion of shed mediastinal blood, and hemofiltration have been reported to be less reliable and may even be harmful in some high-risk patients. Consideration of the available data allows formulation of a 4-pronged plan for limiting excessive blood transfusion after surgery: 1) recognize the causes of excessive transfusion, including the importance of red blood cell volume, type of procedure being performed, preoperative aspirin ingestion, etc.; 2) establish a quality management program, including a survey of transfusion practices that emphasizes physician education and availability of real-time laboratory testing to guide transfusion therapy; 3) adopt a multimodal approach using institution-proven techniques; and

  17. Tooth-bleaching procedures and their controversial effects: A literature review

    PubMed Central

    Alqahtani, Mohammed Q.

    2014-01-01

    Aim This review article will help clinicians improve their understanding of the history of bleaching procedures, bleaching types, components, mechanisms, and their effects on soft tissue, tooth structures, resin composite, and bonding. Methods The controversial issues about bleaching procedures and their effects are reviewed. Additionally, the consequences of pre- and post-bleaching on the bonding potential of composite resin restorations to tooth structure are discussed. Conclusion The overall goal of the paper is to help reduce risks for patients. PMID:25408594

  18. A review of the regenerative endodontic treatment procedure.

    PubMed

    Lee, Bin-Na; Moon, Jong-Wook; Chang, Hoon-Sang; Hwang, In-Nam; Oh, Won-Mann; Hwang, Yun-Chan

    2015-08-01

    Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment.

  19. A review of the regenerative endodontic treatment procedure

    PubMed Central

    Lee, Bin-Na; Moon, Jong-Wook; Chang, Hoon-Sang; Hwang, In-Nam; Oh, Won-Mann

    2015-01-01

    Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment. PMID:26295020

  20. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  1. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  2. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  3. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... water quality standards that were derived, or are as protective as or more protective than could be... procedure by which water quality-based effluent limits and total maximum daily loads are developed using...

  4. 42 CFR 426.340 - Procedures for review of new evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Procedures for review of new evidence. 426.340 Section 426.340 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM REVIEW OF NATIONAL COVERAGE DETERMINATIONS AND LOCAL...

  5. 20 CFR 404.976 - Procedures before Appeals Council on review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Procedures before Appeals Council on review. 404.976 Section 404.976 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Determinations, Administrative Review Process, and Reopening...

  6. 7 CFR 658.7 - USDA assistance with Federal agencies' reviews of policies and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false USDA assistance with Federal agencies' reviews of... PROTECTION POLICY ACT § 658.7 USDA assistance with Federal agencies' reviews of policies and procedures. (a... the purpose and policy of the Act. (c) USDA will provide certain assistance to other Federal...

  7. 7 CFR 658.7 - USDA assistance with Federal agencies' reviews of policies and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false USDA assistance with Federal agencies' reviews of... PROTECTION POLICY ACT § 658.7 USDA assistance with Federal agencies' reviews of policies and procedures. (a... the purpose and policy of the Act. (c) USDA will provide certain assistance to other Federal...

  8. 7 CFR 658.7 - USDA assistance with Federal agencies' reviews of policies and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false USDA assistance with Federal agencies' reviews of... PROTECTION POLICY ACT § 658.7 USDA assistance with Federal agencies' reviews of policies and procedures. (a... the purpose and policy of the Act. (c) USDA will provide certain assistance to other Federal...

  9. 34 CFR 303.342 - Procedures for IFSP development, review, and evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... development, review, and evaluation. (a) Meeting to develop initial IFSP—timelines. For a child referred to... 34 Education 2 2012-07-01 2012-07-01 false Procedures for IFSP development, review, and evaluation... PROGRAM FOR INFANTS AND TODDLERS WITH DISABILITIES Child Find, Evaluations and Assessments,...

  10. 34 CFR 303.342 - Procedures for IFSP development, review, and evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... development, review, and evaluation. (a) Meeting to develop initial IFSP—timelines. For a child referred to... 34 Education 2 2014-07-01 2013-07-01 true Procedures for IFSP development, review, and evaluation... PROGRAM FOR INFANTS AND TODDLERS WITH DISABILITIES Child Find, Evaluations and Assessments,...

  11. 34 CFR 303.342 - Procedures for IFSP development, review, and evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... development, review, and evaluation. (a) Meeting to develop initial IFSP—timelines. For a child referred to... 34 Education 2 2013-07-01 2013-07-01 false Procedures for IFSP development, review, and evaluation... PROGRAM FOR INFANTS AND TODDLERS WITH DISABILITIES Child Find, Evaluations and Assessments,...

  12. 34 CFR 303.342 - Procedures for IFSP development, review, and evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... development, review, and evaluation. (a) Meeting to develop initial IFSP—timelines. For a child who has been... 34 Education 2 2011-07-01 2010-07-01 true Procedures for IFSP development, review, and evaluation... child and the child's family must be conducted every six months, or more frequently if...

  13. Review of numerical procedures for computational surface thermochemistry

    NASA Technical Reports Server (NTRS)

    Milos, Frank S.; Rasky, Daniel J.

    1994-01-01

    Models and equations for surface thermochemistry and near-surface thermophysics of aerodynamically heated thermal protection materials are reviewed, with particular emphasis on computational boundary conditions for surface mass and energy transfer. The surface energy and mass balances, coupled with an appropriate ablation or surface catalysis model, provide complete thermochemical boundary conditions for a true multidisciplinary solution of the fully coupled fluid-dynamics/solid mechanics problem. Practical approximate solutions can be obtained by using a detailed model with full thermophysics for either the solid or fluid phase and a semianalytic method for the other half of the problem. A significant increase in the state-of-the-art in aerothermal computational fluid dynamics is possible by uniting computational fluid dynamic (CFD) methodology with surface thermochemistry boundary conditions and the heat-balance-integral method.

  14. The Photochemical Reflectance Index (PRI) 20 years later: what have we learned?

    NASA Astrophysics Data System (ADS)

    Gamon, J. A.

    2012-12-01

    The Photochemical Reflectance Index (PRI) was originally derived as a measure of diurnal xanthophyll cycle activity and photosynthetic light-use efficiency (LUE). Based on experimental studies of plant canopies in the early 1990's, PRI is derived from reflectance at two wavelengths: 531 nm (the xanthophyll cycle wavelength) and a reference wavelength (unaffected by the xanthophyll cycle). Like any index approach, it has key advantages and disadvantages. Advantages include data reduction and a demonstrated correlation with biochemical and physiological processes tied to photosynthetic light regulation. Disadvantages include sensitivity to a number of confounding factors that include pigment pool sizes, vegetation canopy structure, and sun and view angle effects. Despite these challenges, many studies have shown some promise in using this index for airborne or satellite assessment of photosynthetic activity. This presentation will review key challenges in using this index for global assessment of photosynthetic activity, and will propose avenues for further research that might strengthen our understanding of the dynamic 531 nm reflectance signal. Alternative and complementary approaches to this index will also be briefly discussed.

  15. Canopy Level Chlorophyll Fluorescence and the PRI in a Cornfield

    NASA Technical Reports Server (NTRS)

    Middleton, Elizabeth M.; Cheng, Yen-Ben; Corp, Lawrence A.; Campbell, Petya K. E.; Huemmrich, K. Fred; Zhang, Qingyuan; Kustas, William P.

    2012-01-01

    Two bio-indicators, the Photochemical Reflectance Index (PRI) and solar-induced red and far-red Chlorophyll Fluorescence (SIF), were derived from directional hyperspectral observations and studied in a cornfield on two contrasting days in the growing season. Both red and far-red SIF exhibited higher values on the day when the canopy in the early senescent stage, but only the far-red SIF showed sensitivity to viewing geometry. Consequently, the red/far-red SIF ratio varied greatly among azimuth positions while the largest values were obtained for the "hotspot" at both growth stages. This ratio was lower (approx.0.88 +/- 0.4) in early July than in August when the ratio approached equivalence (near approx.1). In concert, the PRI exhibited stronger responses to both zenith and azimuth angles and different values on the two growth stages. The potential of using these indices to monitor photosynthetic activities needs further investigation

  16. A Review of Clinical Data for Currently Approved Hysteroscopic Sterilization Procedures

    PubMed Central

    Basinski, Cindy M

    2010-01-01

    Two hysteroscopic permanent sterilization procedures are approved for use in the United States: Essure® Permanent Birth Control System (Conceptus Incorporated, Mountain View, CA) and Adiana® Permanent Contraception (Hologic, Inc., Bedford, MA). This review compares the clinical trial data for these procedures. A notable difference is the resultant clinical pregnancy risk. The clinical trials for the Essure procedure have reported no pregnancies in 643 relying women in the 9 years since initiation of the studies. The clinical trial for the Adiana procedure has reported 12 pregnancies in 570 relying women in nearly 5 years of collected data. Other clinical outcome parameters concerning Essure and Adiana are examined in this review. PMID:21364861

  17. Prodifferentiation Activity of Novel Vitamin D2 Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells

    PubMed Central

    Nachliely, Matan; Sharony, Ehud; Bolla, Narasimha Rao; Kutner, Andrzej; Danilenko, Michael

    2016-01-01

    1α,25-dihydroxyvitamin D3 (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D2 is less toxic than vitamin D3 in animals. Here, we determined the differentiation effects of novel analogs of 1α,25-dihydroxyvitamin D2 (1,25D2), PRI-1916 and PRI-1917, in which the extended side chains of their previously reported precursors (PRI-1906 and PRI-1907, respectively) underwent further 24Z (24-cis) modification. Using four human AML cell lines representing different stages of myeloid maturation (KG-1a, HL60, U937, and MOLM-13), we found that the potency of PRI-1916 was slightly higher or equal to that of PRI-1906 while PRI-1917 was significantly less potent than PRI-1907. We also demonstrated that 1,25D2 was a less effective differentiation agent than 1,25D3 in these cell lines. Irrespective of their differentiation potency, all the vitamin D2 derivatives tested were less potent than 1,25D3 in transactivating the DR3-type vitamin D response elements. However, similar to 1,25D3, both 1,25D2 and its analogs could strongly cooperate with the plant polyphenol carnosic acid in inducing cell differentiation and inhibition of G1–S cell cycle transition. These results indicate that the 24Z modification has contrasting effects on the differentiation ability of PRI-1906 and PRI-1907 and that the addition of a plant polyphenol could result in a similar extent of cell differentiation induced by different vitamin D compounds. The enhanced antileukemic effects of the tested combinations may constitute the basis for the development of novel approaches for differentiation therapy of AML. PMID:27399677

  18. Retinoids: Literature Review and Suggested Algorithm for Use Prior to Facial Resurfacing Procedures

    PubMed Central

    Buchanan, Patrick J; Gilman, Robert H

    2016-01-01

    Vitamin A-containing products have been used topically since the early 1940s to treat various skin conditions. To date, there are four generations of retinoids, a family of Vitamin A-containing compounds. Tretinoin, all-trans-retinoic acid, is a first-generation, naturally occurring, retinoid. It is available, commercially, as a gel or cream. The authors conducted a complete review of all studies, clinical- and basic science-based studies, within the literature involving tretinoin treatment recommendations for impending facial procedures. The literature currently lacks definitive recommendations for the use of tretinoin-containing products prior to undergoing facial procedures. Tretinoin pretreatment regimens vary greatly in terms of the strength of retinoid used, the length of the pre-procedure treatment, and the ideal time to stop treatment before the procedure. Based on the current literature and personal experience, the authors set forth a set of guidelines for the use of tretinoin prior to various facial procedures. PMID:27761082

  19. Impact of 3D Rotational Angiography on Liver Embolization Procedures: Review of Technique and Applications

    SciTech Connect

    Lucatelli, Pierleone Corona, Mario Argirò, Renato Anzidei, Michele; Vallati, Giulio; Fanelli, Fabrizio Bezzi, Mario Catalano, Carlo

    2015-06-15

    In the last years, the interest into interventional applications of C-arm cone-beam CT (CBCT) progressively raised, widening its clinical application from the original field of interventional neuroradiology to the field of peripheral procedures. Liver embolization procedures, due to their complexity and potential treatment-related life-threatening complications, represent one of the main clinical applications of this novel angiographic technique. CBCT has been demonstrated to render procedures safer and technically easier, and to predict outcome as well as to avoid major complications in different treatment scenarios (trans-arterial embolization, trans-arterial chemoembolization, selective internal radiation therapy, percutaneous portal vein embolization). This review summarizes all technical, dosimetric and procedural aspects of CBCT techniques, underlying all its potential clinical advantages in the field of liver embolization procedures. Moreover, the paper provides all the instructions to obtain the best diagnostic performance out of this novel angiographic technique.

  20. 21 CFR 601.25 - Review procedures to determine that licensed biological products are safe, effective, and not...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Review procedures to determine that licensed... AND HUMAN SERVICES (CONTINUED) BIOLOGICS LICENSING Biologics Licensing § 601.25 Review procedures to... category of products. (a) Advisory review panels. The Commissioner of Food and Drugs shall appoint...

  1. 21 CFR 601.25 - Review procedures to determine that licensed biological products are safe, effective, and not...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Review procedures to determine that licensed... AND HUMAN SERVICES (CONTINUED) BIOLOGICS LICENSING Biologics Licensing § 601.25 Review procedures to... category of products. (a) Advisory review panels. The Commissioner of Food and Drugs shall appoint...

  2. 21 CFR 601.25 - Review procedures to determine that licensed biological products are safe, effective, and not...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Review procedures to determine that licensed... AND HUMAN SERVICES (CONTINUED) BIOLOGICS LICENSING Biologics Licensing § 601.25 Review procedures to... category of products. (a) Advisory review panels. The Commissioner of Food and Drugs shall appoint...

  3. 40 CFR 132.5 - Procedures for adoption and EPA review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM § 132.5 Procedures for adoption and EPA review... System (NPDES) program modifications under 40 CFR 123.62; and (4) General information which will aid EPA... Attorney General or other appropriate legal authority pursuant to 40 CFR 123.62 and 40 CFR 131.6(e)...

  4. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of certain... under 24 CFR parts 50 and 58. 55.10 Section 55.10 Housing and Urban Development Office of the...

  5. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of certain... under 24 CFR parts 50 and 58. 55.10 Section 55.10 Housing and Urban Development Office of the...

  6. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of certain... under 24 CFR parts 50 and 58. 55.10 Section 55.10 Housing and Urban Development Office of the...

  7. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Floodplain Management § 55.10 Environmental review procedures under 24 CFR parts 50 and 58. (a) Where an... subject to 24 CFR part 58) of proposed actions in a floodplain. (b) The categorical exclusion of certain... under 24 CFR parts 50 and 58. 55.10 Section 55.10 Housing and Urban Development Office of the...

  8. 47 CFR 76.945 - Procedures for Commission review of basic service rates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Procedures for Commission review of basic service rates. 76.945 Section 76.945 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation §...

  9. 47 CFR 76.945 - Procedures for Commission review of basic service rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Procedures for Commission review of basic service rates. 76.945 Section 76.945 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation §...

  10. 15 CFR 400.32 - Procedure for review of request for approval of manufacturing or processing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Procedure for review of request for approval of manufacturing or processing. 400.32 Section 400.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) FOREIGN-TRADE ZONES BOARD, DEPARTMENT OF...

  11. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation facility... license and Certificate of Insurance to the Commander, Naval Facilities Engineering Command or his... Facilities Engineering Command or his designated representative. (1) Upon receipt, the Commander,...

  12. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation facility... license and Certificate of Insurance to the Commander, Naval Facilities Engineering Command or his... Facilities Engineering Command or his designated representative. (1) Upon receipt, the Commander,...

  13. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation facility... license and Certificate of Insurance to the Commander, Naval Facilities Engineering Command or his... Facilities Engineering Command or his designated representative. (1) Upon receipt, the Commander,...

  14. 21 CFR 814.44 - Procedures for review of a PMA.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES FDA Action on a PMA § 814.44 Procedures for review... effectiveness of the device, which was the basis for the order approving the PMA, including information about any adverse effects of the device on health, is available on the Internet and has been placed...

  15. 21 CFR 814.44 - Procedures for review of a PMA.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES FDA Action on a PMA § 814.44 Procedures for review... effectiveness of the device, which was the basis for the order approving the PMA, including information about any adverse effects of the device on health, is available on the Internet and has been placed...

  16. 21 CFR 814.44 - Procedures for review of a PMA.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES FDA Action on a PMA § 814.44 Procedures for review... detailed summary of information respecting the safety and effectiveness of the device, which was the basis for the order approving the PMA, including information about any adverse effects of the device...

  17. 40 CFR 63.54 - Preconstruction review procedures for new affected sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE... Act Sections, Sections 112(g) and 112(j) § 63.54 Preconstruction review procedures for new affected... section 112(g) of the Act, then the owner or operator must comply with those requirements in order...

  18. 40 CFR 63.54 - Preconstruction review procedures for new affected sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE... Act Sections, Sections 112(g) and 112(j) § 63.54 Preconstruction review procedures for new affected... section 112(g) of the Act, then the owner or operator must comply with those requirements in order...

  19. 40 CFR 63.54 - Preconstruction review procedures for new affected sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE... Act Sections, Sections 112(g) and 112(j) § 63.54 Preconstruction review procedures for new affected... section 112(g) of the Act, then the owner or operator must comply with those requirements in order...

  20. The Generalization of Behavior Modification Procedures: A Review--with Special Emphasis on Classroom Applications

    ERIC Educational Resources Information Center

    Wildman, Robert W., II; Wildman, Robert W.

    1975-01-01

    Reports of the use of behavior modification in the classroom are reviewed, with special attention given to whether or not generalization of the effects of the behavior modification programs was obtained. The authors develop a set of 15 proposed "rules" for obtaining generalization of the effects of behavior modification procedures. (Author)

  1. Behavioristic Procedures in the Treatment of Autistic Children: A Review of the Literature.

    ERIC Educational Resources Information Center

    Akiyama, Robert M.

    Children with infantile autism display characteristics and behaviors that severely limit their growth and functioning on many levels. Research is reviewed in which principles of operant conditioning are implemented in procedures designed to investigate and/or modify the autistic child's behavior in the following areas: (a) social interaction, (b)…

  2. 75 FR 50750 - Streamlined Procedure for Appeal Brief Review in Inter Partes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... United States Patent and Trademark Office Streamlined Procedure for Appeal Brief Review in Inter Partes... appeal briefs filed in inter partes reexamination proceeding appeals to increase the efficiency of the appellate process and to reduce the pendency of appeals. The Chief Judge of the Board of Patent Appeals...

  3. 32 CFR 861.5 - DOD Commercial Airlift Review Board procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false DOD Commercial Airlift Review Board procedures. 861.5 Section 861.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE... consider reinstating a suspended carrier on either CARB motion or carrier motion, unless such carrier...

  4. 77 FR 36532 - Review of Small Generator Interconnection Agreements and Procedures; Solar Energy Industries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ...-001; ER12-1855-000] Review of Small Generator Interconnection Agreements and Procedures; Solar Energy... discuss issues related to a petition for rulemaking recently submitted by the Solar Energy Industries... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY...

  5. 32 CFR 861.5 - DOD Commercial Airlift Review Board procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false DOD Commercial Airlift Review Board procedures. 861.5 Section 861.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE... operations, maintenance, transportation, or air safety fields. A Chairman and alternate will be...

  6. A Qualitative Analysis of the Determinants in the Choice of a French Journal Reviewing Procedures

    ERIC Educational Resources Information Center

    Morge, Ludovic

    2015-01-01

    Between 1993 and 2010, two French journals (Aster and Didaskalia) coming from different backgrounds but belonging to the same institution used to publish papers on research in science and technology education. The merging of these journals made it necessary for them to compare the different reviewing procedures used by each. This merging occurred…

  7. 36 CFR 223.191 - Sourcing area disapproval and review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Sourcing area disapproval and review procedures. 223.191 Section 223.191 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER The Forest Resources...

  8. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  9. 32 CFR 766.8 - Procedure for review, approval, execution and distribution of aviation facility licenses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... distribution of aviation facility licenses. 766.8 Section 766.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES USE OF DEPARTMENT OF THE NAVY AVIATION FACILITIES BY CIVIL AIRCRAFT § 766.8 Procedure for review, approval, execution and distribution of aviation...

  10. A qualitative analysis of the determinants in the choice of a French journal reviewing procedures

    NASA Astrophysics Data System (ADS)

    Morge, Ludovic

    2015-12-01

    Between 1993 and 2010, two French journals (Aster and Didaskalia) coming from different backgrounds but belonging to the same institution used to publish papers on research in science and technology education. The merging of these journals made it necessary for them to compare the different reviewing procedures used by each. This merging occurred at a time when research is becoming increasingly international which partly determines some of the reviewing procedure choices. In order for a francophone international journal to survive, it needs to take this internationalization into account in a reasoned manner. The author of this article, as a chief editor of RDST (Recherches en Didactique des Sciences et des Technologies)—the journal resulting from the merging- taking part in this merger, analyses the social, cultural and pragmatic determinants which impacted the choices made in reviewing procedures. This paper describes how these diversity of factors leads us to drop the idea of a standard reviewing procedure which would be valid for all journals.

  11. Procedural sedation: A review of sedative agents, monitoring, and management of complications

    PubMed Central

    Tobias, Joseph D.; Leder, Marc

    2011-01-01

    Given the continued increase in the complexity of invasive and noninvasive procedures, healthcare practitioners are faced with a larger number of patients requiring procedural sedation. Effective sedation and analgesia during procedures not only provides relief of suffering, but also frequently facilitates the successful and timely completion of the procedure. However, any of the agents used for sedation and/or analgesia may result in adverse effects. These adverse effects most often affect upper airway patency, ventilatory function or the cardiovascular system. This manuscript reviews the pharmacology of the most commonly used agents for sedation and outlines their primary effects on respiratory and cardiovascular function. Suggested guidelines for the avoidance of adverse effects through appropriate pre-sedation evaluation, early identification of changes in respiratory and cardiovascular function, and their treatment are outlined. PMID:22144928

  12. Welfare implications of invasive piglet husbandry procedures, methods of alleviation and alternatives: a review.

    PubMed

    Sutherland, M A

    2015-01-01

    Iron administration, teeth clipping, tail docking and castration are common invasive husbandry procedures performed on piglets on commercial farms, generally within the first week of life. These procedures are performed to prevent potential health and welfare problems of piglets and/or the sow, or, with respect to castration, to enhance meat quality. The objectives of this review were firstly, to provide the rationale and scientific evidence for performing these procedures, secondly, to describe the welfare implications of these procedures, and lastly, to describe mitigation strategies or alternatives that can be used to eliminate or reduce the pain caused by these procedures. Administering supplementary iron is necessary to prevent anaemia in piglets and the procedure has a low welfare impact. The stated benefits of teeth clipping to prevent udder lesions do not appear to outweigh the risk from injury and infection in piglets following the procedure. Tail docking reduces the prevalence of tail biting, but does not eliminate this behaviour and the practice of tail docking can cause acute pain. Castration is primarily performed to reduce the occurrence of boar taint, but alternatives are now available that negate the need to perform this procedure. Teeth clipping, tail docking and castration all cause behavioural and physiological changes indicative of acute pain and can have potentially long-term negative consequences such as causing abscesses, lesions and the formation of neuromas. Therefore effective pain mitigation strategies (e.g. analgesia, local or general anaesthesia) that markedly alleviate the pain caused by these procedures are necessary to improve the welfare of piglets. Alternatively, if management practices are available that eliminate the need for performing these procedures altogether, then they should be adopted. PMID:25204203

  13. Dissemination of Periodontal Pathogens in the Bloodstream after Periodontal Procedures: A Systematic Review

    PubMed Central

    Horliana, Anna Carolina Ratto Tempestini; Chambrone, Leandro; Foz, Adriana Moura; Artese, Hilana Paula Carillo; Rabelo, Mariana de Sousa; Pannuti, Cláudio Mendes; Romito, Giuseppe Alexandre

    2014-01-01

    Background To date, there is no compilation of evidence-based information associating bacteremia and periodontal procedures. This systematic review aims to assess magnitude, duration, prevalence and nature of bacteremia caused by periodontal procedures. Study Design Systematic Review Types of Studies Reviewed MEDLINE, EMBASE and LILACS databases were searched in duplicate through August, 2013 without language restriction. Observational studies were included if blood samples were collected before, during or after periodontal procedures of patients with periodontitis. The methodological quality was assessed in duplicate using the modified Newcastle-Ottawa scale (NOS). Results Search strategy identified 509 potentially eligible articles and nine were included. Only four studies demonstrated high methodological quality, whereas five were of medium or low methodological quality. The study characteristics were considered too heterogeneous to conduct a meta-analysis. Among 219 analyzed patients, 106 (49.4%) had positive bacteremia. More frequent bacteria were S. viridans, A. actinomycetemcomitans P. gingivalis, M. micros and species Streptococcus and Actinomyces, although identification methods of microbiologic assays were different among studies. Clinical Implications Although half of the patients presented positive bacteremia after periodontal procedures, accurate results regarding the magnitude, duration and nature of bacteremia could not be confidentially assessed. PMID:24870125

  14. The risk of radiation exposure to assisting staff in urological procedures: a literature review.

    PubMed

    Jindal, Tarun

    2013-01-01

    Fluoroscopy is an integral part of urology and is used for various procedures, such as extra-corporeal shock wave lithotripsy, percutaneous nephrolithotomy, uretero-renoscopy, and ureteral stenting. This technique exposes the urologist and assistants to radiation, which is known to have deleterious effects. Although there have been studies that determine the amount of exposure and the risks to the operating urologist, the risk to the assisting staff remains largely undetermined. A literature review was conducted to determine the risk of radiation exposure during urological procedures, with emphasis on data concerning assisting staff. Data from nine major studies is presented in this article.

  15. Evidence for a cytoplasmic microprocessor of pri-miRNAs.

    PubMed

    Shapiro, Jillian S; Langlois, Ryan A; Pham, Alissa M; Tenoever, Benjamin R

    2012-07-01

    microRNAs (miRNAs) represent a class of noncoding RNAs that fine-tune gene expression through post-transcriptional silencing. While miRNA biogenesis occurs in a stepwise fashion, initiated by the nuclear microprocessor, rare noncanonical miRNAs have also been identified. Here we characterize the molecular components and unique attributes associated with the processing of virus-derived cytoplasmic primary miRNAs (c-pri-miRNAs). RNA in situ hybridization and inhibition of cellular division demonstrated a complete lack of nuclear involvement in c-pri-miRNA cleavage while genetic studies revealed that maturation still relied on the canonical nuclear RNase III enzyme, Drosha. The involvement of Drosha was mediated by a dramatic relocalization to the cytoplasm following virus infection. Deep sequencing analyses revealed that the cytoplasmic localization of Drosha does not impact the endogenous miRNA landscape during infection, despite allowing for robust synthesis of virus-derived miRNAs in the cytoplasm. Taken together, this research describes a unique function for Drosha in the processing of highly structured cytoplasmic RNAs in the context of virus infection.

  16. Three causes of variation in the photochemical reflectance index (PRI) in evergreen conifers.

    PubMed

    Wong, Christopher Y S; Gamon, John A

    2015-04-01

    The photochemical reflectance index (PRI) reflects diurnal xanthophyll cycle activity and is also influenced by seasonally changing carotenoid : Chl pigment ratios. Both changing pigment pools and xanthophyll cycle activity contribute to photoprotection in evergreen conifers exposed to boreal winters, but they operate over different timescales, and their relative contribution to the PRI signal has often been unclear. To clarify these responses and their contribution to the PRI signal, leaf PRI, pigment composition, temperature and irradiance were monitored over 2 yr for two evergreen conifers (Pinus contorta and Pinus ponderosa) in a boreal climate. PRI was affected by three distinct processes operating over different timescales and exhibiting contrasting spectral responses. Over the 2 yr study period, the greatest change in PRI resulted from seasonally changing carotenoid : Chl pigment ratios, followed by a previously unreported shifting leaf albedo during periods of deep cold. Remarkably, the smallest change was attributable to the xanthophyll cycle. To properly distinguish these three effects, interpretation of PRI must consider temporal context, physiological responses to evolving environmental conditions, and spectral response. Consideration of the separate mechanisms affecting PRI over different timescales could greatly improve efforts to monitor changing photosynthetic activity using optical remote sensing. PMID:25408288

  17. Diffuse sky radiation influences the relationship between canopy PRI and shadow fraction

    NASA Astrophysics Data System (ADS)

    Mõttus, Matti; Takala, Tuure L. H.; Stenberg, Pauline; Knyazikhin, Yuri; Yang, Bin; Nilson, Tiit

    2015-07-01

    The Photochemical Reflectance Index (PRI) of green leaves is an indicator of photosynthetic downregulation: when the photosynthetic apparatus is close to the saturation limit, PRI becomes dependent on light conditions. Therefore, by measuring the PRI of leaves under different local irradiance conditions, it should be possible to determine the saturation level of the leaves and obtain information on the light use efficiency (LUE) of a vegetation canopy. The dependence of PRI on the ratio of sunlit to shaded foliage (quantified by the canopy shadow fraction) in the field of view of an instrument has been used to remotely measure canopy LUE on clear days. However, besides photosynthetic downregulation, the dependence of canopy PRI on shadow fraction is affected by the blue sky radiation caused by scattering in the atmosphere. To quantify this effect on remotely sensed PRI, we present the underlying definitions relating leaf and canopy PRI and perform the required calculations for typical midsummer conditions in Central Finland. We demonstrate that the effect of blue sky radiation on the variation of PRI with canopy shadow fraction is similar in shape and magnitude to that of LUE variations reported in literature.

  18. 7 CFR 1c.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... an expedited review procedure shall adopt a method for keeping all members advised of research... research involving no more than minimal risk, and for minor changes in approved research. 1c.110 Section 1c... review procedures for certain kinds of research involving no more than minimal risk, and for...

  19. 10 CFR 745.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.110 Expedited review procedures for... 10 Energy 4 2010-01-01 2010-01-01 false Expedited review procedures for certain kinds of research... for Human Research Protections, HHS, or any successor office. (b) An IRB may use the expedited...

  20. 49 CFR 11.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... an expedited review procedure shall adopt a method for keeping all members advised of research... research involving no more than minimal risk, and for minor changes in approved research. 11.110 Section 11... Expedited review procedures for certain kinds of research involving no more than minimal risk, and for...

  1. Comparison of the predictive validity and consistency among preference assessment procedures: a review of the literature.

    PubMed

    Kang, Soyeon; O'Reilly, Mark; Lancioni, Giulio; Falcomata, Terry S; Sigafoos, Jeff; Xu, Ziwei

    2013-04-01

    We reviewed 14 experimental studies comparing different preference assessments for individuals with developmental disabilities that were published in peer-reviewed journals between 1985 and 2012. Studies were summarized based on the following six variables: (a) the number of participants, (b) the type of disability, (c) the number and type of stimuli, (d) the average duration of administration, (e) compared procedures, and (f) results. Studies were also classified in terms of the predictive validity and consistency of the preference assessment results. The results suggest the preference assessment procedures that may produce more accurate predictions for the reinforcing effects of identified stimuli and consistent preference results. The findings are discussed in relation to the previous literature. Evidence based modifications of the most efficient preference assessment are also discussed. PMID:23357675

  2. Is acupuncturing effective in controlling the gag reflex during dental procedures? A review of literature

    PubMed Central

    Daneshkazemi, Alireza; Daneshkazemi, Pedram; Davoudi, Amin; Badrian, Hamid; Firouzabadi, Vahid Pourtalebi

    2016-01-01

    Traditional acupuncture has been introduced more than 2500 years ago which provides an alternative and complementary option during clinical practices. Its main mechanism is based on stimulating the nerves by altering the processes and perception of pain transmitters. It facilitates releasing natural pain relievers such as endorphins and serotonin. Its success for various dental procedures has been proved earlier. However, its effects on controlling the gag reflex seem to be overlooked. The gag reflex is recognized as a protective reaction for stopping the entrance of any foreign bodies into the oropharynx. Pronounced gag reflexes can have negative impacts on the quality of dental procedures. Many techniques have been suggested for managing this reflex and acupuncturing is one of those which seems to be overlooked recently. The aim of this paper is reviewing the published high-quality researches about the efficacy of this technique for eliminating the gag reflex during dental procedures. PMID:27212742

  3. Is acupuncturing effective in controlling the gag reflex during dental procedures? A review of literature.

    PubMed

    Daneshkazemi, Alireza; Daneshkazemi, Pedram; Davoudi, Amin; Badrian, Hamid; Firouzabadi, Vahid Pourtalebi

    2016-01-01

    Traditional acupuncture has been introduced more than 2500 years ago which provides an alternative and complementary option during clinical practices. Its main mechanism is based on stimulating the nerves by altering the processes and perception of pain transmitters. It facilitates releasing natural pain relievers such as endorphins and serotonin. Its success for various dental procedures has been proved earlier. However, its effects on controlling the gag reflex seem to be overlooked. The gag reflex is recognized as a protective reaction for stopping the entrance of any foreign bodies into the oropharynx. Pronounced gag reflexes can have negative impacts on the quality of dental procedures. Many techniques have been suggested for managing this reflex and acupuncturing is one of those which seems to be overlooked recently. The aim of this paper is reviewing the published high-quality researches about the efficacy of this technique for eliminating the gag reflex during dental procedures. PMID:27212742

  4. Commander Young reviews clipboard notes and procedures on forward flight deck

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Commander Young reviews clipboard notes and procedures in forward flight deck commanders ejection seat (S1) wearing communication kit assembly (assy) headset (hdst) while hdst cable floats at his side. Soon after the launch phase of STS-1, crewmembers changed from their high altitude pressure garments into the light blue constant wear garment. Commanders Station control panels, rotational hand controller (RHC), crewman optical alignment sight (COAS), forward windows, window shade, and flight mirror assy appear in view.

  5. Assessment System for Aircraft Noise (ASAN) citation database. Volume 3: New citation review procedures

    NASA Astrophysics Data System (ADS)

    Reddingius, Nicolaas; Kugler, Andrew B.

    1989-12-01

    The Assessment System for Aircraft Noise (ASAN) includes a database of several thousand references to the literature on the impact of noise and sonic booms on humans, animals and structures. Bibliographic data, abstracts and critical reviews of key documents can be retrieved. A systematic methodology for the selection and evaluation of new citations to be added to the database consistent with the procedures used in CITASAN is described.

  6. MS Peterson eats while reviewing procedures with Commander Weitz on middeck

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Mission Specialist (MS) Peterson, holding food container, eats while reviewing procedures with Commander Weitz (wearing bifocals) on middeck in front of starboard wall. Weitz points out an item in the frew activity plan (CAP) to Peterson as the mission specialist uses a spoon to eat a meal aboard the Earth-orbiting Challenger, Orbiter Vehicle (OV) 099. Weitz and Peterson are wearing the shirt and trouser portions of the light blue cotton multi-piece constant wear garments.

  7. Considerations for the direct pulp capping procedure in primary teeth: a review of the literature.

    PubMed

    Kopel, H M

    1992-01-01

    In reviewing the various studies concerning the direct pulp capping procedure in primary teeth, using rigid criteria for case selection and procedure appears to insure a significant amount of success. It is acknowledged that vital primary pulp tissue is capable of healing without resorting to complete pulpectomy, although statistically direct pulp capping has been found to be less successful in primary teeth than indirect pulp therapy or coronal amputation (pulpotomy). To achieve success for direct pulp capping in primary teeth, the considerations involve: selecting teeth with minimal or no clinical signs of pulpal inflammation; or pretreating the carious tooth with a sedative restoration before excavating the caries; disinfecting the cavity floor; enlarging the actual exposure, and flushing out dentinal debris with mild solutions; controlling bleeding by not allowing a clot to form; placing a hard-set, CaOH material over the exposure, followed by a fast-setting, zinc oxide-eugenol cement to achieve a hermetic seal; and lastly, placing a stainless steel crown to minimize microleakage and prevent a fractured or defective restoration. These procedural steps can hardly ensure complete success in direct pulp capping of a primary tooth; but, based on the many cited investigations in this review, a significant amount of success can be expected without resorting more frequently to invasive techniques. Surely the evidence presented leading to the feasibility of direct pulp capping in primary teeth merits further investigations, before dogmatically rejecting this procedure of pulp therapy. PMID:1583199

  8. REVIEW Of COMPUTERIZED PROCEDURE GUIDELINES FOR NUCLEAR POWER PLANT CONTROL ROOMS

    SciTech Connect

    David I Gertman; Katya Le Blanc; Ronald L Boring

    2011-09-01

    Computerized procedures (CPs) are recognized as an emerging alternative to paper-based procedures for supporting control room operators in nuclear power plants undergoing life extension and in the concept of operations for advanced reactor designs. CPs potentially reduce operator workload, yield increases in efficiency, and provide for greater resilience. Yet, CPs may also adversely impact human and plant performance if not designed and implemented properly. Therefore, it is important to ensure that existing guidance is sufficient to provide for proper implementation and monitoring of CPs. In this paper, human performance issues were identified based on a review of the behavioral science literature, research on computerized procedures in nuclear and other industries, and a review of industry experience with CPs. The review of human performance issues led to the identification of a number of technical gaps in available guidance sources. To address some of the gaps, we developed 13 supplemental guidelines to support design and safety. This paper presents these guidelines and the case for further research.

  9. Continuous neuropathic pain secondary to endoscopic procedures: report of two cases and review of the literature.

    PubMed

    Kalladka, Mythili; Nasri-Heir, Cibele; Eliav, Eli; Ananthan, Sowmya; Viswanath, Archana; Heir, Gary

    2016-08-01

    Neuropathic pain encompasses a spectrum of conditions that can arise from a lesion or dysfunction of the central or the peripheral nervous system, and it may develop at variable intervals after nerve injury or inflammation. Nerve injuries arising from surgical procedures commonly occur secondary to the surgical trauma, and in rare instances they are a complication of intubation during general anesthesia or endoscopic procedures. A series of 2 cases of bilateral glossopharyngeal neuropathic pain subsequent to endoscopic procedures is presented with a review of the literature concerning the mechanisms of development of neuropathic pain after these procedures. The purpose of these case reports is to make dentists aware of the occurrence, the mechanisms of nerve injuries, and the treatment of neuropathic pain after endoscopic procedures. In the first case, the patient had relief of pain with a combination therapy of clonazepam 1.0 mg in divided doses twice daily and gabapentin 300 mg in divided doses 3 times daily. In the second case, the patient had significant relief of pain with a monotherapy of gabapentin 1200 mg in divided doses 3 times daily. PMID:27422430

  10. Review of Test Procedure for Determining HSPFs of Residential Variable-Speed Heat Pumps

    SciTech Connect

    Rice, C. Keith; Munk, Jeffrey D.; Shrestha, Som S.

    2015-08-01

    This report reviews the suitability of the existing Heating Seasonal Performance Factor (HSPF) ratings and testing requirements for the current generation of variable-speed (VS) air-source heat pumps. Recent field test results indicate larger discrepancies between rated HSPF and field-observed HSPF for VS models than for single-speed models in the same houses. These findings suggest that the heating season test and ratings procedure should be revisited for VS heat pumps. The ratings and testing procedures are described in ANSI/AHRI 210/240 (2008) for single-speed, two-capacity, and variable-speed units. Analysis of manufacturer and independent test performance data on VS units reveals why the current VS testing/ratings procedure results in overly optimistic HSPF ratings for some VS units relative to other types of heat pumps. This is due to a combination of extrapolation of low speed test data beyond the originally anticipated ambient temperature operating range and the constraints of unit controls, which prevent low speed operation over the range of ambient temperatures assumed in the procedure for low speed. As a result, the HSPFs of such units are being overpredicted relative to those for single- and two-capacity designs. This overprediction has been found to be significantly reduced by use in the HSPF ratings procedure of an alternative higher-load heating load line, described in a companion report (Rice et al., 2015).

  11. Correcting the relationship between PRI and shadow fraction for the blue sky effect

    NASA Astrophysics Data System (ADS)

    Mõttus, Matti

    2016-04-01

    The Photochemical Reflectance Index (PRI) is defined as the normalized difference ratio of leaf reflectance at two specific wavelengths in the green spectral region. Its value depends on the status of leaf carotenoid content, and especially that of the xanthophyll cycle pigments. Due to the dependence on the xanthophyll cycle, when the photosynthetic apparatus of green leaves is close to the saturation limit, their PRI becomes dependent on light conditions. Therefore, by measuring the PRI of leaves in the same canopy under different local irradiance conditions on a sunny day, it should be possible to determine the saturation level of the leaves. In turn, this gives information on the light use efficiency (LUE) of the vegetation canopy. The average light conditions of visible foliage elements are often quantified with the shadow fraction -- the fraction of visible foliage not lit by direct sunlight. The dependence of PRI on the shadow fraction has been used to remotely measure canopy LUE on clear days. Variations in shadow fraction have been achieved with multiangular measurement. However, besides photosynthetic downregulation, the dependence of canopy PRI on shadow fraction is affected by the blue sky radiation caused by scattering in the atmosphere. To quantify this effect on remotely sensed PRI, we present the underlying definitions relating leaf and canopy PRI and perform the required calculations for typical midsummer conditions in Central Finland. We demonstrate that the effect of blue sky radiation on the variation of PRI with canopy shadow fraction is similar in shape and magnitude to that of LUE variations reported in literature. Next, we propose a new method to assess these PRI variations in structured vegetation. We investiagate this blue sky effect on the PRI -- shadow fraction relationship with high spatial (60 cm) and spectral (9.8 nm) resolution airborne imaging spectroscopy data from Hyytiälä, Finland. We evaluate the spectral irradiance in

  12. Atrioesophageal fistula following ablation procedures for atrial fibrillation: systematic review of case reports

    PubMed Central

    Chavez, Patricia; Messerli, Franz H; Casso Dominguez, Abel; Aziz, Emad F; Sichrovsky, Tina; Garcia, Daniel; Barrett, Connor D; Danik, Stephan

    2015-01-01

    Background Atrioesophageal fistula (AEF) is a rare but serious adverse event of atrial fibrillation (AF) ablation. Objective To identify the clinical characteristics of AEF following ablation procedures for AF and determine the associated mortality. Methods A systematic review of observational cases of AEF following ablation procedures for AF was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. Results 53 cases were identified. Mean age was 54±13 years; 73% (39/53) of cases occurred in males. Mean interval between procedure and presentation was 20±12 days, ranging from 2 to 60 days. AEF was observed in 12 patients who underwent surgical radiofrequency ablation (RFA) and in 41 patients with percutaneous RFA. Fever was the most common presenting symptom (n=44) followed by neurological deficits (n=27) and haematemesis (n=19). CT of the chest (n=27) was the preferred diagnostic test. Patients who did not receive a primary esophageal repair were more likely to have a deadly outcome (34% vs 83%; p<0.05). No difference in mortality rate was found between patients who underwent surgical RFA when compared with percutaneous RFA (58% vs 56%; p=0.579). No association was found between onset of symptoms and mortality (19±10 vs 23±14 days; p=0.355). Conclusions AEF following ablation procedures for AF is a serious complication with high mortality rates. Presenting symptoms most often include a triad of fever, neurological deficit and/or haematemesis within 60 days of procedure. The preferred diagnostic test is CT of the chest. The treatments of choice is surgical repair. PMID:26380098

  13. Advanced human-system interface design review guideline. Evaluation procedures and guidelines for human factors engineering reviews

    SciTech Connect

    O`Hara, J.M.; Brown, W.S.; Baker, C.C.; Welch, D.L.; Granda, T.M.; Vingelis, P.J.

    1994-07-01

    Advanced control rooms will use advanced human-system interface (HSI) technologies that may have significant implications for plant safety in that they will affect the operator`s overall role in the system, the method of information presentation, and the ways in which operators interact with the system. The U.S. Nuclear Regulatory Commission (NRC) reviews the HSI aspects of control rooms to ensure that they are designed to good human factors engineering principles and that operator performance and reliability are appropriately supported to protect public health and safety. The principal guidance available to the NRC, however, was developed more than ten years ago, well before these technological changes. Accordingly, the human factors guidance needs to be updated to serve as the basis for NRC review of these advanced designs. The purpose of this project was to develop a general approach to advanced HSI review and the human factors guidelines to support. NRC safety reviews of advanced systems. This two-volume report provides the results of the project. Volume I describes the development of the Advanced HSI Design Review Guideline (DRG) including (1) its theoretical and technical foundation, (2) a general model for the review of advanced HSIs, (3) guideline development in both hard-copy and computer-based versions, and (4) the tests and evaluations performed to develop and validate the DRG. Volume I also includes a discussion of the gaps in available guidance and a methodology for addressing them. Volume 2 provides the guidelines to be used for advanced HSI review and the procedures for their use.

  14. Systematic review of clinical trials of cervical manipulation: control group procedures and pain outcomes

    PubMed Central

    2011-01-01

    Objective To characterize the types of control procedures used in controlled clinical trials of cervical spine manipulation and to evaluate the outcomes obtained by subjects in control groups so as to improve the quality of future clinical trials Methods A search of relevant clinical trials was performed in PubMed 1966-May 2010 with the following key words: "Chiropractic"[Mesh] OR "Manipulation, Spinal"[Mesh]) AND "Clinical Trial "[Publication Type]. Reference lists from these trials were searched for any additional trials. The reference lists of two prior studies, one review and one original study were also searched. Accepted reports were then rated for quality by 2 reviewers using the PEDro scale. Studies achieving a score of >50% were included for data extraction and analysis. Intra-group change scores on pain outcomes were obtained. For determining clinically important outcomes, a threshold of 20% improvement was used where continuous data were available; otherwise, an effect size of 0.30 was employed Results The PubMed search yielded 753 citations of which 13 were selected. Eight (8) other studies were identified by reviewing two systematic reviews and through reference searches. All studies scored >50% on the PEDro scale. There were 9 multi-session studies and 12 single-session studies. The most commonly used control procedure was "manual contact/no thrust". Four (4) studies used a placebo-control (patient blinded). For two of these studies with VAS data, the average change reported was 4.5 mm. For the other control procedures, variable results were obtained. No clinically important changes were reported in 57% of the paired comparisons, while, in 43% of these, changes which would be considered clinically important were obtained in the control groups. Only 15% of trials reported on post-intervention group registration. Conclusions Most control procedures in cervical manipulation trials result in small clinical changes, although larger changes are observed in

  15. Retrospective review of Contura HDR breast cases to improve our standardized procedure

    SciTech Connect

    Iftimia, Ileana; Cirino, Eileen T.; Ladd, Ron; Mower, Herbert W.; McKee, Andrea B.

    2013-07-01

    To retrospectively review our first 20 Contura high dose rate breast cases to improve and refine our standardized procedure and checklists. We prepared in advance checklists for all steps, developed an in-house Excel spreadsheet for second checking the plan, and generated a procedure for efficient contouring and a set of optimization constraints to meet the dose volume histogram criteria. Templates were created in our treatment planning system for structures, isodose levels, optimization constraints, and plan report. This study reviews our first 20 high dose rate Contura breast treatment plans. We followed our standardized procedure for contouring, planning, and second checking. The established dose volume histogram criteria were successfully met for all plans. For the cases studied here, the balloon-skin and balloon-ribs distances ranged between 5 and 43 mm and 1 and 33 mm, respectively; air{sub s}eroma volume/PTV{sub E}val volume≤5.5% (allowed≤10%); asymmetry<1.2 mm (goal≤2 mm); PTV{sub E}val V90%≥97.6%; PTV{sub E}val V95%≥94.9%; skin max dose≤98%Rx; ribs max dose≤137%Rx; V150%≤29.8 cc; V200%≤7.8 cc; the total dwell time range was 225.4 to 401.9 seconds; and the second check agreement was within 3%. Based on this analysis, more appropriate ranges for the total dwell time and balloon diameter tolerance were found. Three major problems were encountered: balloon migration toward the skin for small balloon-to-skin distances, lumen obstruction, and length change for the flexible balloon. Solutions were found for these issues and our standardized procedure and checklists were updated accordingly. Based on our review of these cases, the use of checklists resulted in consistent results, indicating good coverage for the target without sacrificing the critical structures. This review helped us to refine our standardized procedure and update our checklists.

  16. USING VIDEO TECHNOLOGY TO DISSEMINATE BEHAVIORAL PROCEDURES: A REVIEW OF FUNCTIONAL ANALYSIS: A GUIDE FOR UNDERSTANDING CHALLENGING BEHAVIOR (DVD)

    PubMed Central

    Carr, James E; Fox, Eric J

    2009-01-01

    Although applied behavior analysis has generated many highly effective behavior-change procedures, the procedures have not always been effectively disseminated. One solution to this problem is the use of video technology, which has been facilitated by the ready availability of video production equipment and software and multiple distribution methods (e.g., DVD, online streaming). We review a recent DVD that was produced to disseminate the successful experimental functional analysis procedure. The review is followed by general recommendations for disseminating behavior-analytic procedures via video technology. PMID:20514204

  17. Monitoring seasonal and diurnal changes in photosynthetic pigments with automated PRI and NDVI sensors

    NASA Astrophysics Data System (ADS)

    Gamon, J. A.; Kovalchuck, O.; Wong, C. Y. S.; Harris, A.; Garrity, S. R.

    2015-07-01

    The vegetation indices normalized difference vegetation index (NDVI) and photochemical reflectance index (PRI) provide indicators of pigmentation and photosynthetic activity that can be used to model photosynthesis from remote sensing with the light-use-efficiency model. To help develop and validate this approach, reliable proximal NDVI and PRI sensors have been needed. We tested new NDVI and PRI sensors, "spectral reflectance sensors" (SRS sensors; recently developed by Decagon Devices, during spring activation of photosynthetic activity in evergreen and deciduous stands. We also evaluated two methods of sensor cross-calibration - one that considered sky conditions (cloud cover) at midday only, and another that also considered diurnal sun angle effects. Cross-calibration clearly affected sensor agreement with independent measurements, with the best method dependent upon the study aim and time frame (seasonal vs. diurnal). The seasonal patterns of NDVI and PRI differed for evergreen and deciduous species, demonstrating the complementary nature of these two indices. Over the spring season, PRI was most strongly influenced by changing chlorophyll : carotenoid pool sizes, while over the diurnal timescale, PRI was most affected by the xanthophyll cycle epoxidation state. This finding demonstrates that the SRS PRI sensors can resolve different processes affecting PRI over different timescales. The advent of small, inexpensive, automated PRI and NDVI sensors offers new ways to explore environmental and physiological constraints on photosynthesis, and may be particularly well suited for use at flux tower sites. Wider application of automated sensors could lead to improved integration of flux and remote sensing approaches for studying photosynthetic carbon uptake, and could help define the concept of contrasting vegetation optical types.

  18. Monitoring seasonal and diurnal changes in photosynthetic pigments with automated PRI and NDVI sensors

    NASA Astrophysics Data System (ADS)

    Gamon, J. A.; Kovalchuk, O.; Wong, C. Y. S.; Harris, A.; Garrity, S. R.

    2015-02-01

    The vegetation indices normalized difference vegetation index (NDVI) and photochemical reflectance index (PRI) provide indicators of pigmentation and photosynthetic activity that can be used to model photosynthesis from remote sensing with the light-use efficiency model. To help develop and validate this approach, reliable proximal NDVI and PRI sensors have been needed. We tested new NDVI and PRI sensors, "SRS" sensors recently developed by Decagon Devices, during spring activation of photosynthetic activity in evergreen and deciduous stands. We also evaluated two methods of sensor cross-calibration, one that considered sky conditions (cloud cover) at midday only, and the other that also considered diurnal sun angle effects. Cross-calibration clearly affected sensor agreement with independent measurements, with the best method dependent upon the study aim and time frame (seasonal vs. diurnal). The seasonal patterns of NDVI and PRI differed for evergreen and deciduous species, demonstrating the complementary nature of these two indices. Over the spring season, PRI was most strongly influenced by changing chlorophyll : carotenoid pool sizes, while over the diurnal time scale PRI was most affected by the xanthophyll cycle epoxidation state. This finding demonstrates that the SRS PRI sensors can resolve different processes affecting PRI over different time scales. The advent of small, inexpensive, automated PRI and NDVI sensors offers new ways to explore environmental and physiological constraints on photosynthesis, and may be particularly well-suited for use at flux tower sites. Wider application of automated sensors could lead to improved integration of flux and remote sensing approaches to studying photosynthetic carbon uptake, and could help define the concept of contrasting vegetation optical types.

  19. Positive Peer Reporting in the Classroom: a Review of Intervention Procedures.

    PubMed

    Murphy, Jillian; Zlomke, Kimberly

    2014-10-01

    Positive peer reporting (PPR) is a classroom-based intervention to improve social interactions between students using rewards and positive social attention. Along with a variant of the procedure referred to as "Tootling," PPR has demonstrated overwhelmingly positive results since its development. However, a unified, standard protocol for successful implementation of PPR interventions has not yet been established. A review of 24 studies, including 48 separately described cases of PPR in classroom settings, provided information concerning adaptations for students in special education, alternative school, and mainstream classrooms. Student participants ranged from preschool (age 4) to eighth grade (age 16). This paper summarizes the common procedural components found across cases described in the studies. A comparison of PPR-based interventions reported in the literature by various research teams also revealed differences in the procedures for targeting individuals or groups, providing training and support, allocating rewards, proceeding with daily peer report sessions, and terminating the intervention. Variations in specific procedural elements that may relate to PPR's effectiveness are discussed. The authors also provide suggestions to guide and support the advancement of standardized methods of PPR for future research and clinical application.

  20. Optimal training design for procedural motor skills: a review and application to laparoscopic surgery.

    PubMed

    Spruit, Edward N; Band, Guido P H; Hamming, Jaap F; Ridderinkhof, K Richard

    2014-11-01

    This literature review covers the choices to consider in training complex procedural, perceptual and motor skills. In particular, we focus on laparoscopic surgery. An overview is provided of important training factors modulating the acquisition, durability, transfer, and efficiency of trained skills. We summarize empirical studies and their theoretical background on the topic of training complex cognitive and motor skills that are pertinent to proficiency in laparoscopic surgery. The overview pertains to surgical simulation training for laparoscopy, but also to training in other demanding procedural and dexterous tasks, such as aviation, managing complex systems and sports. Evidence-based recommendations are provided for facilitating efficiency in laparoscopic motor skill training such as session spacing, adaptive training, task variability, part-task training, mental imagery and deliberate practice.

  1. Pain and anxiety management for pediatric dental procedures using various combinations of sedative drugs: A review.

    PubMed

    Gazal, Giath; Fareed, Wamiq Musheer; Zafar, Muhammad Sohail; Al-Samadani, Khalid H

    2016-07-01

    For fearful and uncooperative children behavioral management techniques are used. In order to control the pain and anxiety in pedodontic patients, pharmacologic sedation, anesthesia and analgesia are commonly used. Midazolam is commonly used as an oral sedation agent in children; it has several features such as safety of use, quick onset and certain degree of amnesia that makes it a desirable sedation agent in children. This review paper discusses various aspects of oral midazolam, ketamine and their combinations in conscious sedation including, advantages of oral route of sedation, pharmacokinetics, range of oral doses, and antagonists for clinical dental treatment procedures. PMID:27330369

  2. Review of data analysis procedures for the ATS-6 millimeter wave experiment

    NASA Technical Reports Server (NTRS)

    Meneghini, R.

    1975-01-01

    Predictions of satellite downlink attenuation through the use of ground based measurements form a substantial part of the ATS-6 millimeter wave experiment (MWE). At the downlink frequencies (20 and 30 GHz), the major causes of attenuation are the density and the size distribution of rain drops along the propagation path. Ground station data, which include radar and rain gauge records, measure quantities related to the meteorological parameters of interest and thereby provide a prediction of downlink attenuation with which the measured attenuation can be compared. The calibration and data analysis procedures used in the MWE are reviewed with the object of improving the accuracy of such ground based predictions.

  3. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for...

  4. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for...

  5. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for...

  6. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for...

  7. 40 CFR 142.17 - Review of State programs and procedures for withdrawal of approved primacy programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Primary Enforcement Responsibility § 142.17 Review of State programs and procedures..., with respect to each State determined to have primary enforcement responsibility, the compliance of...

  8. 40 CFR 142.17 - Review of State programs and procedures for withdrawal of approved primacy programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS IMPLEMENTATION Primary Enforcement Responsibility § 142.17 Review of State programs and procedures..., with respect to each State determined to have primary enforcement responsibility, the compliance of...

  9. Ravitch versus Nuss procedure for pectus excavatum: systematic review and meta-analysis

    PubMed Central

    Kanagaratnam, Aran; Phan, Steven; Tchantchaleishvilli, Vakhtang

    2016-01-01

    Background Pectus excavatum is the most common congenital chest wall deformity. The two most common surgical techniques for its correction are the modified Ravitch technique and the minimally invasive Nuss technique. Despite both procedures being used widely, data comparing them are scarce. Methods We conducted a systematic review and meta-analysis of comparative studies to evaluate these procedures. A systematic search of the literature was performed from six electronic databases. Pooled meta-analysis was conducted using odds ratio (OR) and weighted mean difference (WMD). Results A total of 13 studies comprising 1,432 pediatric (79.3%) and adult (20.7%) patients were identified, including 912 patients undergoing the Nuss procedure compared to 520 patients undergoing the Ravitch procedure. There was no significant difference found between the Nuss group versus Ravitch group in pediatric patients with regard to overall complications (OR =1.16; 95% CI: 0.61–2.19; I2=56%; P=0.65), reoperations (6.1% vs. 6.4%; OR =1.00; 95% CI: 0.40–2.50; I2=0%; P=1.00), wound infections (OR =0.58; 95% CI: 0.23–1.46; I2=0%; P=0.25), hemothorax (1.6% vs. 1.3%; OR =0.74; 95% CI: 0.21–2.65; I2=12%; P=0.64), pneumothorax (3.4% vs. 1.5%; OR =1.11; 95% CI: 0.42–2.93; I2=0%; P=0.83) or pneumonia (OR =0.15; 95% CI: 0.02–1.48; I2=0%; P=0.10). Adult patients undergoing the Nuss procedure had a higher incidence of overall complications (OR =3.26; 95% CI: 1.01–10.46; I2=0%; P=0.05), though there were far fewer studies that reported data. Conclusions These results suggest no difference between the Nuss and Ravitch procedures for pediatric patients, while in adults the Ravitch procedure resulted in fewer complications. PMID:27747174

  10. 36 CFR 1260.42 - What are the procedures for agency personnel to review records at a NARA facility?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... damage to archival materials. See 36 CFR part 1254 for more information on acceptable equipment. ... handling of archival materials. (b) Agency reviewers must: (1) Follow NARA security regulations and abide by NARA procedures for handling archival materials; (2) Follow NARA procedures for identifying...

  11. 28 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of research proposals which have been approved under the procedure. (d) The department or agency head... kinds of research involving no more than minimal risk, and for minor changes in approved research. 46... SUBJECTS § 46.110 Expedited review procedures for certain kinds of research involving no more than...

  12. 16 CFR 1028.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of research proposals which have been approved under the procedure. (d) The department or agency head... kinds of research involving no more than minimal risk, and for minor changes in approved research. 1028... HUMAN SUBJECTS § 1028.110 Expedited review procedures for certain kinds of research involving no...

  13. 38 CFR 16.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 16.110 Section 16.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.110 Expedited review procedures for certain kinds of...

  14. 38 CFR 16.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 16.110 Section 16.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.110 Expedited review procedures for certain kinds of...

  15. 38 CFR 16.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 16.110 Section 16.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.110 Expedited review procedures for certain kinds of...

  16. 38 CFR 16.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 16.110 Section 16.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.110 Expedited review procedures for certain kinds of...

  17. 75 FR 36357 - Clarification on the Procedure for Seeking Review of a Finding of a Substantial New Question of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ...The United States Patent and Trademark Office (USPTO) is clarifying the procedure for seeking review of a determination that a substantial new question of patentability (SNQ) has been raised in an ex parte reexamination proceeding. This notice clarifies that while issues related to a SNQ determination are procedural, the Chief Judge of the Board of Patent Appeals and Interferences (BPAI) has......

  18. Pri sORF peptides induce selective proteasome-mediated protein processing.

    PubMed

    Zanet, J; Benrabah, E; Li, T; Pélissier-Monier, A; Chanut-Delalande, H; Ronsin, B; Bellen, H J; Payre, F; Plaza, S

    2015-09-18

    A wide variety of RNAs encode small open-reading-frame (smORF/sORF) peptides, but their functions are largely unknown. Here, we show that Drosophila polished-rice (pri) sORF peptides trigger proteasome-mediated protein processing, converting the Shavenbaby (Svb) transcription repressor into a shorter activator. A genome-wide RNA interference screen identifies an E2-E3 ubiquitin-conjugating complex, UbcD6-Ubr3, which targets Svb to the proteasome in a pri-dependent manner. Upon interaction with Ubr3, Pri peptides promote the binding of Ubr3 to Svb. Ubr3 can then ubiquitinate the Svb N terminus, which is degraded by the proteasome. The C-terminal domains protect Svb from complete degradation and ensure appropriate processing. Our data show that Pri peptides control selectivity of Ubr3 binding, which suggests that the family of sORF peptides may contain an extended repertoire of protein regulators.

  19. Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication.

    PubMed Central

    Masai, H; Asai, T; Kubota, Y; Arai, K; Kogoma, T

    1994-01-01

    Under certain conditions, Escherichia coli cells exhibit either of two altered modes of chromosomal DNA replication. These are inducible stable DNA replication (iSDR), seen in SOS-induced cells, and constitutive stable DNA replication (cSDR), seen in rnhA mutants. Both iSDR and cSDR can continue to occur in the absence of protein synthesis. They are dependent on RecA protein, but do not require DnaA protein or the oriC site. Here we report the requirement for PriA, a protein essential for assembly of the phi X174-type primosome, for both iSDR and cSDR. In priA1(Null)::kan mutant cells, iSDR is not observed after induction by thymine starvation. Replication from one of the origins (oriM1) specific to iSDR is greatly reduced by the priA1::kan mutation. cSDR in rnhA224 mutant cells deficient in RNase HI is also completely abolished by the same priA mutation. In both cases, SDR is restored by introduction of a plasmid carrying a wild-type priA gene. Furthermore, the viability of an rnhA::cat dnaA46 strain is lost at 42 degrees C upon inactivation of the priA gene, indicating the lethal effect of priA inactivation on those cells whose viability depends on cSDR. These results demonstrate that a function of PriA protein is essential for iSDR and cSDR and suggest the involvement of the PriA-dependent phi X174-type primosome in these DnaA/oriC-independent pathways of chromosome replication. Whereas ColE1-type plasmids, known to be independent of DnaA, absolutely require PriA function for replication, DnaA-dependent plasmid replicons such as pSC101, F, R6K, Rts1 and RK2 are able to transform and to be maintained in the priA1::kan strain.(ABSTRACT TRUNCATED AT 250 WORDS) Images PMID:7525276

  20. Review of edgematchimg procedures for digital cartographic data used in Geographic Information Systems (GIS)

    USGS Publications Warehouse

    Nebert, D.D.

    1989-01-01

    In the process of developing a continuous hydrographic data layer for water resources applications in the Pacific Northwest, map-edge discontinuities in the U.S. Geological Survey 1:100 ,000-scale digital data that required application of computer-assisted edgematching procedures were identified. The spatial data sets required by the project must have line features that match closely enough across map boundaries to ensure full line topology when adjacent files are joined by the computer. Automated edgematching techniques are evaluated as to their effects on positional accuracy. Interactive methods such as selective node-matching and on-screen editing are also reviewed. Interactive procedures complement automated methods by allowing supervision of edgematching in a cartographic and hydrologic context. Common edge conditions encountered in the preparation of the Northwest Rivers data base are described, as are recommended processing solutions. Suggested edgematching procedures for 1:100,000-scale hydrography data are included in an appendix to encourage consistent processing of this theme on a national scale. (USGS)

  1. Minor surgery procedures: A retrospective review and prospective survey in a pediatric population

    PubMed Central

    Chan, Emily; Bucevska, Marija; Verchere, Cynthia

    2015-01-01

    OBJECTIVE: The present study evaluated minor surgery procedures undertaken by a single plastic surgeon at BC Children’s Hospital (Vancouver, British Columbia) for patient and physician satisfaction, parent impressions, psychological concerns and complications. METHODS: Data were collected from a retrospective chart review and a prospective patient survey. Eligible subjects for the retrospective study included all pediatric patients undergoing minor surgery between May 2011 and April 2013. Parameters of interest included patient demographics, minor surgery specifics, complications and outcomes. Eligible subjects for the prospective patient survey included consecutive patients undergoing minor surgery between June 2013 and August 2013, as well as their parents. RESULTS: A total of 219 procedures were included in the retrospective review. The mean age of subjects was 13.1 years (range two weeks to 18 years). The median length of follow-up was 46 days (range four to 606 days). There were no major complications; however, 45 minor complications in 36 patients were found. Complications included crusting (4.6%), delayed wound healing (3.2%), hypersensitivity (2.3%), scar hypertrophy (1.8%), infection (0.9%) and other (7.8%). Outcomes were categorized as one of four outcomes: both satisfied (89.9%); patient satisfied but physician unsatisfied (0.8%); patient unsatisfied and physician satisfied (3.1%); and both unsatisfied (6.2%). In the prospective study, 32 subjects consented to participate in the survey. Of these subjects, 10 children and 12 parents responded to the questionnaires. Eighty-three percent of respondents indicated that their goals were accomplished by their procedure and that they would be willing to undergo minor surgery again. CONCLUSION: Minor surgery is possible and practical in pediatric plastic surgery clinics, with few complications and high patient and surgeon satisfaction. PMID:26361627

  2. The priA gene encoding the primosomal replicative n' protein of Escherichia coli.

    PubMed Central

    Lee, E H; Masai, H; Allen, G C; Kornberg, A

    1990-01-01

    The Escherichia coli gene encoding protein n' has been isolated and named priA for primosomal protein A. Protein n' is absolutely required for the conversion of single-stranded phi X174 DNA to the duplex replicative form in an in vitro-reconstituted system. The gene maps to 88.7 minutes on the chromosome adjacent to the cytR locus. Soluble protein extracts from cells harboring the priA gene on a multicopy plasmid contained 45-fold more n' replication activity than wild-type extracts. Enhanced overproduction of greater than 1000-fold was achieved by replacing the natural Shine-Dalgarno sequence with that of the phage T7 phi 10 gene and placing this priA under the control of the T7 phage promoter and RNA polymerase. The priA sequence reveals a 732-amino acid open reading frame and a nucleotide-binding consensus site consistent with the size and ATPase activity of the purified protein. The gene for protein n has been named priB and the putative gene for protein n", priC. Images PMID:2162050

  3. Effect and evaluation of prying action for top- and seat-angle connections

    NASA Astrophysics Data System (ADS)

    Ahmed, Ali; Hasan, Rafiq

    2015-06-01

    Nonlinear finite element (FE) static analyses of top- and seat-angle connections were performed using ABAQUS standard to investigate the influence of connection parameters and its properties on prying action developed due to the interaction between column flange and top angle's vertical leg. Contact phenomenon between two interfaces with finite sliding and bolt pretension in the initial step of analysis was considered in the FE model. FE analysis results were compared with the experimental ones to examine the applicability of the FE model. Then, the location of plastic hinges in connection assemblages was investigated at the ultimate state of the connection and a parametric study was performed varying connection parameters, material properties of connection assemblages, and magnitude of bolt pretension to visualize their effects on prying force and on the position of prying force on top angle's vertical leg. Current study shows that plastic hinges not only develop at top angle's heel and bolt hole region but also in the bolt shank that differs from some assumptions of power model (Kishi and Chen 1990): (1) top angle thickness and gage distance from angle heel to bolt hole center line have an distinct effect on prying action; and (2) distributed prying force developed near the region of the top edge of tension angle's leg adjacent to column flange can contribute to the failure of the connection. Finally, a mathematical formulation to identify the location of prying force action point is proposed.

  4. Documentation of various approaches and outcomes in patients on warfarin undergoing dental procedures: a review article

    PubMed Central

    Shaer, Fayez El; Raslan, Ismael; Osaimi, Nora Al; Bawazeer, Ghada; Alayobi, Fhakr; Alhogbani, Tarek; Kharabsheh, Suliman; Habeeb, Walid Al

    2016-01-01

    Appropriate management of patients with mechanical prosthetic valves on warfarin during dental procedures is crucial. If the patients continue warfarin, they might develop bleeding, while interruption of therapy can cause thromboembolic events. Bridging therapy (mostly heparin) is used in some patients, while others stop medications. There is no unifying protocol. Information on management of patients on warfarin undergoing dental procedures in Saudi Arabia is lacking. Therefore, the current study aimed to provide more insight into various approaches utilized by clinicians to deal with such patients at a large teaching hospital in Riyadh, and to evaluate the frequency and severity of bleeding and thromboembolic complications during different types of dental procedures in this population. This was a cohort study. Patient records were used to collect data on peri-procedural management of patients on warfarin, continuation or interruption of warfarin therapy, as well as bleeding and thromboembolic complications. Fifty medical records were reviewed from March to October 2012. Regarding management, 10% had no proper documentation, 74% underwent bridging therapy, 12% discontinued warfarin therapy, and 4% continued warfarin. Of the patients, 31% had minor bleeding (15% in patients on bridging therapy and 16% in patients continuing warfarin). Thromboembolic complications were documented in 4%, (2% in those on bridging therapy and 2% in those discontinuing warfarin). Patients on bridging therapy (heparin) were admitted to the hospital for a mean of five days, and none of the other patients were admitted. Adopting the protocol to continue warfarin caused bleeding tendency that was controlled with the usual measures, with more cost effectiveness, and no thromboembolic risks. PMID:27679745

  5. Documentation of various approaches and outcomes in patients on warfarin undergoing dental procedures: a review article

    PubMed Central

    Shaer, Fayez El; Raslan, Ismael; Osaimi, Nora Al; Bawazeer, Ghada; Alayobi, Fhakr; Alhogbani, Tarek; Kharabsheh, Suliman; Habeeb, Walid Al

    2016-01-01

    Appropriate management of patients with mechanical prosthetic valves on warfarin during dental procedures is crucial. If the patients continue warfarin, they might develop bleeding, while interruption of therapy can cause thromboembolic events. Bridging therapy (mostly heparin) is used in some patients, while others stop medications. There is no unifying protocol. Information on management of patients on warfarin undergoing dental procedures in Saudi Arabia is lacking. Therefore, the current study aimed to provide more insight into various approaches utilized by clinicians to deal with such patients at a large teaching hospital in Riyadh, and to evaluate the frequency and severity of bleeding and thromboembolic complications during different types of dental procedures in this population. This was a cohort study. Patient records were used to collect data on peri-procedural management of patients on warfarin, continuation or interruption of warfarin therapy, as well as bleeding and thromboembolic complications. Fifty medical records were reviewed from March to October 2012. Regarding management, 10% had no proper documentation, 74% underwent bridging therapy, 12% discontinued warfarin therapy, and 4% continued warfarin. Of the patients, 31% had minor bleeding (15% in patients on bridging therapy and 16% in patients continuing warfarin). Thromboembolic complications were documented in 4%, (2% in those on bridging therapy and 2% in those discontinuing warfarin). Patients on bridging therapy (heparin) were admitted to the hospital for a mean of five days, and none of the other patients were admitted. Adopting the protocol to continue warfarin caused bleeding tendency that was controlled with the usual measures, with more cost effectiveness, and no thromboembolic risks.

  6. Modern meta-heuristics based on nonlinear physics processes: A review of models and design procedures

    NASA Astrophysics Data System (ADS)

    Salcedo-Sanz, S.

    2016-10-01

    Meta-heuristic algorithms are problem-solving methods which try to find good-enough solutions to very hard optimization problems, at a reasonable computation time, where classical approaches fail, or cannot even been applied. Many existing meta-heuristics approaches are nature-inspired techniques, which work by simulating or modeling different natural processes in a computer. Historically, many of the most successful meta-heuristic approaches have had a biological inspiration, such as evolutionary computation or swarm intelligence paradigms, but in the last few years new approaches based on nonlinear physics processes modeling have been proposed and applied with success. Non-linear physics processes, modeled as optimization algorithms, are able to produce completely new search procedures, with extremely effective exploration capabilities in many cases, which are able to outperform existing optimization approaches. In this paper we review the most important optimization algorithms based on nonlinear physics, how they have been constructed from specific modeling of a real phenomena, and also their novelty in terms of comparison with alternative existing algorithms for optimization. We first review important concepts on optimization problems, search spaces and problems' difficulty. Then, the usefulness of heuristics and meta-heuristics approaches to face hard optimization problems is introduced, and some of the main existing classical versions of these algorithms are reviewed. The mathematical framework of different nonlinear physics processes is then introduced as a preparatory step to review in detail the most important meta-heuristics based on them. A discussion on the novelty of these approaches, their main computational implementation and design issues, and the evaluation of a novel meta-heuristic based on Strange Attractors mutation will be carried out to complete the review of these techniques. We also describe some of the most important application areas, in

  7. 34 CFR 602.32 - Procedures for Department review of applications for recognition or for change in scope...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Process Application and Review by Department Staff § 602.32 Procedures for Department review of... criteria. The analysis of an application for recognition and, as appropriate, of a compliance report, or of... evaluation of the agency, the staff— (1) Prepares a written draft analysis of the agency; (2) Sends the...

  8. 34 CFR 602.32 - Procedures for Department review of applications for recognition or for change in scope...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Process Application and Review by Department Staff § 602.32 Procedures for Department review of... criteria. The analysis of an application for recognition and, as appropriate, of a compliance report, or of... evaluation of the agency, the staff— (1) Prepares a written draft analysis of the agency; (2) Sends the...

  9. 34 CFR 602.32 - Procedures for Department review of applications for recognition or for change in scope...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Process Application and Review by Department Staff § 602.32 Procedures for Department review of... criteria. The analysis of an application for recognition and, as appropriate, of a compliance report, or of... evaluation of the agency, the staff— (1) Prepares a written draft analysis of the agency; (2) Sends the...

  10. 34 CFR 602.32 - Procedures for Department review of applications for recognition or for change in scope...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Process Application and Review by Department Staff § 602.32 Procedures for Department review of... criteria. The analysis of an application for recognition and, as appropriate, of a compliance report, or of... evaluation of the agency, the staff— (1) Prepares a written draft analysis of the agency; (2) Sends the...

  11. A Meta-Analytic Review of the Cover-Copy-Compare and Variations of This Self-Management Procedure

    ERIC Educational Resources Information Center

    Joseph, Laurice M.; Konrad, Moira; Cates, Gary; Vajcner, Terra; Eveleigh, Elisha; Fishley, Katelyn M.

    2012-01-01

    Studies that examined copy-cover-compare (CCC) and variations of this procedure were reviewed and analyzed. This review revealed a substantial number of studies that validated the use of CCC across spelling and math skills and across students with and without disabilities. A meta-analysis of findings indicated that CCC and variations of this…

  12. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... review procedure shall adopt a method for keeping all members advised of research proposals which have... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section 46... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review...

  13. Non-Respiratory Indications for Polysomnography and Related Procedures in Children: An Evidence-Based Review

    PubMed Central

    Kotagal, Suresh; Nichols, Cynthia D.; Grigg-Damberger, Madeleine M.; Marcus, Carole L.; Witmans, Manisha B.; Kirk, Valerie G.; D'Andrea, Lynn A.; Hoban, Timothy F.

    2012-01-01

    Objective: This evidence-based review provides a systematic and comprehensive review of the literature regarding the utility of polysomnography for the evaluation of non-respiratory sleep disorders in children including hypersomnias, parasomnias, sleep-related movement disorders, and sleep in other special populations. Methods: A task force of pediatric sleep medicine experts performed a systematic review of the literature regarding the use of polysomnography for non-respiratory sleep disorders in children. They identified and graded 76 papers as evidence. Results: The main results include (1) polysomnography combined with the multiple sleep latency test is useful for evaluating disorders of excessive somnolence to objectively quantify sleepiness. The results have to be interpreted with consideration of the pubertal stage and regularity of the sleep patterns of the child; (2) polysomnography is indicated in children with parasomnias or sleep related movement disorders who have a high likelihood of having obstructive sleep apnea (OSA); (3) polysomnography is not routinely indicated in children with enuresis unless there is a high likelihood of OSA; (4) polysomnography can be helpful in evaluating children with restless legs syndrome (RLS) and when periodic limb movement disorder (PLMD) is suspected. Conclusions: These findings suggest that, in children with non-respiratory sleep disorders, polysomnography should be a part of a comprehensive sleep evaluation in selected circumstances to determine the nature of the events in more detail or when the suspicion of OSA is relatively high. Citation: Kotagal S; Nichols CD; Grigg-Damberger MM; Marcus CL; Witmans MB; Kirk VG; D'Andrea LA; Hoban TF. Non-respiratory indications for polysomnography and related procedures in children: an evidence-based review. SLEEP 2012;35(11):1451-1466. PMID:23115394

  14. Lung radiofrequency and microwave ablation: a review of indications, techniques and post-procedural imaging appearances

    PubMed Central

    Jennings, P E

    2015-01-01

    Lung ablation can be used to treat both primary and secondary thoracic malignancies. Evidence to support its use, particularly for metastases from colonic primary tumours, is now strong, with survival data in selected cases approaching that seen after surgery. Because of this, the use of ablative techniques (particularly thermal ablation) is growing and the Royal College of Radiologists predict that the number of patients who could benefit from such treatment may reach in excess of 5000 per year in the UK. Treatment is often limited to larger regional centres, and general radiologists often have limited awareness of the current indications and the techniques involved. Furthermore, radiologists without any prior experience are frequently expected to interpret post-treatment imaging, often performed in the context of acute complications, which have occurred after discharge. This review aims to provide an overview of the current indications for pulmonary ablation, together with the techniques involved and the range of post-procedural appearances. PMID:25465192

  15. Improved enteral tolerance following step procedure: systematic literature review and meta-analysis.

    PubMed

    Fernandes, Melissa A; Usatin, Danielle; Allen, Isabel E; Rhee, Sue; Vu, Lan

    2016-10-01

    Surgical management of children with short bowel syndrome (SBS) changed with the introduction of the serial transverse enteroplasty procedure (STEP). We conducted a systematic review and meta-analysis using MEDLINE and SCOPUS to determine if children with SBS had improved enteral tolerance following STEP. Studies were included if information about a child's pre- and post-STEP enteral tolerance was provided. A random effects meta-analysis provided a summary estimate of the proportion of children with enteral tolerance increase following STEP. From 766 abstracts, seven case series involving 86 children were included. Mean percent tolerance of enteral nutrition improved from 35.1 to 69.5. Sixteen children had no enteral improvement following STEP. A summary estimate showed that 87 % (95 % CI 77-95 %) of children who underwent STEP had an increase in enteral tolerance. Compilation of the literature supports the belief that SBS subjects' enteral tolerance improves following STEP. Enteral nutritional tolerance is a measure of efficacy of STEP and should be presented as a primary or secondary outcome. By standardizing data collection on children undergoing STEP procedure, better determination of nutritional benefit from STEP can be ascertained. PMID:27461428

  16. Improved enteral tolerance following step procedure: systematic literature review and meta-analysis.

    PubMed

    Fernandes, Melissa A; Usatin, Danielle; Allen, Isabel E; Rhee, Sue; Vu, Lan

    2016-10-01

    Surgical management of children with short bowel syndrome (SBS) changed with the introduction of the serial transverse enteroplasty procedure (STEP). We conducted a systematic review and meta-analysis using MEDLINE and SCOPUS to determine if children with SBS had improved enteral tolerance following STEP. Studies were included if information about a child's pre- and post-STEP enteral tolerance was provided. A random effects meta-analysis provided a summary estimate of the proportion of children with enteral tolerance increase following STEP. From 766 abstracts, seven case series involving 86 children were included. Mean percent tolerance of enteral nutrition improved from 35.1 to 69.5. Sixteen children had no enteral improvement following STEP. A summary estimate showed that 87 % (95 % CI 77-95 %) of children who underwent STEP had an increase in enteral tolerance. Compilation of the literature supports the belief that SBS subjects' enteral tolerance improves following STEP. Enteral nutritional tolerance is a measure of efficacy of STEP and should be presented as a primary or secondary outcome. By standardizing data collection on children undergoing STEP procedure, better determination of nutritional benefit from STEP can be ascertained.

  17. The PRiMA-linked Cholinesterase Tetramers Are Assembled from Homodimers

    PubMed Central

    Chen, Vicky P.; Xie, Heidi Q.; Chan, Wallace K. B.; Leung, K. Wing; Chan, Gallant K. L.; Choi, Roy C. Y.; Bon, Suzanne; Massoulié, Jean; Tsim, Karl W. K.

    2010-01-01

    Acetylcholinesterase (AChE) is anchored onto cell membranes by the transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric globular form that is prominently expressed in vertebrate brain. In parallel, the PRiMA-linked tetrameric butyrylcholinesterase (BChE) is also found in the brain. A single type of AChE-BChE hybrid tetramer was formed in cell cultures by co-transfection of cDNAs encoding AChET and BChET with proline-rich attachment domain-containing proteins, PRiMA I, PRiMA II, or a fragment of ColQ having a C-terminal GPI addition signal (QN-GPI). Using AChE and BChE mutants, we showed that AChE-BChE hybrids linked with PRiMA or QN-GPI always consist of AChET and BChET homodimers. The dimer formation of AChET and BChET depends on the catalytic domains, and the assembly of tetramers with a proline-rich attachment domain-containing protein requires the presence of C-terminal “t-peptides” in cholinesterase subunits. Our results indicate that PRiMA- or ColQ-linked cholinesterase tetramers are assembled from AChET or BChET homodimers. Moreover, the PRiMA-linked AChE-BChE hybrids occur naturally in chicken brain, and their expression increases during development, suggesting that they might play a role in cholinergic neurotransmission. PMID:20566626

  18. The procedures used to review safety analysis reports for packagings submitted to the US Department of Energy for certification

    SciTech Connect

    Popper, G.F.; Raske, D.T.; Turula, P.

    1988-01-01

    This paper presents an overview of the procedures used at the Argonne National Laboratory (ANL) to review Safety Analysis Reports for Packagings (SARPs) submitted to the US Department of Energy (DOE) for issuance of a Certificate of Compliance. Prior to certification and shipment of a packaging for the transport of radioactive materials, a SARP must be prepared describing the design, contents, analyses, testing, and safety features of the packaging. The SARP must be reviewed to ensure that the specific packaging meets all DOE orders and federal regulations for safe transport. The ANL SARP review group provides an independent review and evaluation function for the DOE to ensure that the packaging meets all the prescribed requirements. This review involves many disciplines and includes evaluating the general information, drawings, construction details, operating procedures, maintenance and test programs, and the quality assurance plan for compliance with requirements. 14 refs., 6 figs.

  19. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein

    NASA Astrophysics Data System (ADS)

    Darwiche, Rabih; Kelleher, Alan; Hudspeth, Elissa M.; Schneiter, Roger; Asojo, Oluwatoyin A.

    2016-06-01

    The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and Pry2. Recombinant Pry1CAP forms dimers in solution, is sufficient for in vitro cholesterol binding, and has comparable binding properties as full-length Pry1. Two crystal structures of Pry1CAP are reported, one with Mg2+ coordinated to the conserved CAP tetrad (His208, Glu215, Glu233 and His250) in spacegroup I41 and the other without divalent cations in spacegroup P6122. The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one of which sits in the cholesterol binding site. Both structures reveal that the divalent cation and cholesterol binding sites are connected upon dimerization, providing a structural basis for the observed Mg2+-dependent sterol binding by Pry1.

  20. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein

    PubMed Central

    Darwiche, Rabih; Kelleher, Alan; Hudspeth, Elissa M.; Schneiter, Roger; Asojo, Oluwatoyin A.

    2016-01-01

    The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and Pry2. Recombinant Pry1CAP forms dimers in solution, is sufficient for in vitro cholesterol binding, and has comparable binding properties as full-length Pry1. Two crystal structures of Pry1CAP are reported, one with Mg2+ coordinated to the conserved CAP tetrad (His208, Glu215, Glu233 and His250) in spacegroup I41 and the other without divalent cations in spacegroup P6122. The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one of which sits in the cholesterol binding site. Both structures reveal that the divalent cation and cholesterol binding sites are connected upon dimerization, providing a structural basis for the observed Mg2+-dependent sterol binding by Pry1. PMID:27344972

  1. Diurnal and Directional Responses of Chlorophyll Fluorescence and the PRI in a Cornfield

    NASA Technical Reports Server (NTRS)

    Middleton, Elizabeth; Cheng, Y. B.; Corp, L.; Campbell, P.; Kustas, W.

    2010-01-01

    Determining the health and vigor of vegetation using high spectral resolution remote sensing is an important goal which has application to monitoring agriculture and ecosystem productivity and carbon exchange. Two spectral indices used to assess whether vegetation is performing near-optimally or exhibiting symptoms of environmental stress (e.g., drought or nutrient deficiency, non-optimal temperatures, etc.) are the Photochemical Reflectance Index (PRI) and solar-induced red and far-red Chlorophyll Fluorescence (Fs). Both the PRI and Fs capture the dynamics of photoprotection mechanisms within green foliage: the PRI is based on the association of the reflected radiation in the green spectrum with the xanthophyll cycle, whereas Fs measures the emitted radiation in the red and far-red spectrum. Fs was determined from retrievals in the atmospheric oxygen absorption features centered at 688 and 760 nm using a modified Fraunhofer Line Depth (FLD) method. We previously demonstrated diurnal and seasonal PRI differences for sunlit vs. shaded foliage in a conifer forest canopy, as expressed in the hotspot and darkspot of the Bidirectional Reflectance Function (BRF). In a USDA-ARS experimental field site located in Beltsville, MD, USA, measurements were acquired over a corn crop from a nadir view in 2008 with an ASD FieldSpec Pro (Analytical Spectral Devices, Inc., Boulder, CO, USA) to study the behavior of the PRI for sunlit and shaded foliage as captured in reflectance variations associated with the BRF, in a I m tall canopy in the vegetative growth stage. Those observations were compared to simulations obtained from two radiative transfer models. Measurements were then acquired to examine whether the PRI and Fs were influenced by view zenith and azimuth geometries at different times of day. Those measurements were made in 2010 with the Ocean Optics USB4000 Miniature Fiber Optic Spectrometer (Ocean Optics Inc., Dunedin, Florida, USA) at several times during the day on

  2. Requirement for RecFOR-mediated recombination in priA mutant.

    PubMed

    Grompone, Gianfranco; Sanchez, Nicolas; Dusko Ehrlich, S; Michel, Bénédicte

    2004-04-01

    Restart of arrested replication forks is an important process and PriA, the main Escherichia coli replication restart protein, is essential for viability under any condition that increases the frequency of fork arrest. In priA mutant, replication forks are arrested by spontaneously occurring roadblocks and blocked replication forks persist as a result of the defect in replication restart. In the present work, we analysed how recombination proteins contribute to the viability of the priA mutant. RecFOR-mediated homologous recombination occurs in a large fraction of priA mutant cells, indicating a frequent formation of DNA single strand gaps and their recombinational repair. This high level of homologous recombination renders the proteins that resolve Holliday junctions recombination intermediates essential for viability. When homologous recombination is blocked at early steps by recFOR or recA inactivation, exonuclease V-mediated DNA degradation is required for full viability of priA mutants, indicating that unrepaired gaps are broken and that DNA degradation of the broken DNA allows the formation of viable cells. Models for the formation of single strand DNA gaps consequently to a replication restart defect and for gap processing are proposed. PMID:15066040

  3. PRI-Modeler: extracting RNA structural elements from PDB files of protein-RNA complexes.

    PubMed

    Han, Kyungsook; Nepal, Chirag

    2007-05-01

    A complete understanding of protein and RNA structures and their interactions is important for determining the binding sites in protein-RNA complexes. Computational approaches exist for identifying secondary structural elements in proteins from atomic coordinates. However, similar methods have not been developed for RNA, due in part to the very limited structural data so far available. We have developed a set of algorithms for extracting and visualizing secondary and tertiary structures of RNA and for analyzing protein-RNA complexes. These algorithms have been implemented in a web-based program called PRI-Modeler (protein-RNA interaction modeler). Given one or more protein data bank files of protein-RNA complexes, PRI-Modeler analyzes the conformation of the RNA, calculates the hydrogen bond (H bond) and van der Waals interactions between amino acids and nucleotides, extracts secondary and tertiary RNA structure elements, and identifies the patterns of interactions between the proteins and RNAs. This paper presents PRI-Modeler and its application to the hydrogen bond and van der Waals interactions in the most representative set of protein-RNA complexes. The analysis reveals several interesting interaction patterns at various levels. The information provided by PRI-Modeler should prove useful for determining the binding sites in protein-RNA complexes. PRI-Modeler is accessible at http://wilab.inha.ac.kr/primodeler/, and supplementary materials are available in the analysis results section at http://wilab.inha.ac.kr/primodeler/.

  4. Shoulder Structure and Function Following the Modified Latarjet Procedure: A Clinical and Radiological Review

    PubMed Central

    Garewal, Devinder; Evans, Mathew; Taylor, David; Hoy, Gregory A.; Barwood, Shane; Connell, David

    2013-01-01

    Background To evaluate the clinical and radiological outcomes of the modified Latarjet procedure for traumatic, antero-inferior glenohumeral joint instability. Methods Case series were used with a mean follow-up of 21.3 months for clinical and radiological review and 47.2 months for recurrent instability. Shoulder function was evaluated by clinical examination and validated shoulder scales: Western Ontario Shoulder Stability Index (WOSI), Melbourne Instability Shoulder Score (MISS) and l'Insalata Shoulder Questionnaire. Shoulder structure was evaluated by computed tomography. Results Thirty-two cases were enrolled (mean age 27.0 years). One patient reported a redislocation during the follow-up period. Clinical examination revealed that the median external rotation (at 0° and 90° abduction) was reduced on the operative side by 7.5° (p < 0.01) and 10° (p < 0.001), respectively. Subjective shoulder function was good. Mean (SD) scores on the WOSI, MISS and l'Insalata scales were 78.0 (19.7), 75.8 (11.5) and 89.3 (9.9), respectively. No loss of subscapularis strength was identified (p > 0.05). Radiological evaluation revealed a mean (SD) pre-operative glenoid surface area loss of 169.5 (48.5) mm2 reconstituted surgically by a bone block of 225.4 (73.8) mm2. Subscapularis muscle bulk was reduced on the operative side, above the level of the muscle split (p < 0.05). Conclusions The Latarjet procedure reliably restores lost glenoid surface area, shoulder stability, strength and function. A small loss of external rotation is expected and related to altered subscapularis anatomy. PMID:27582905

  5. Fluorescence, PRI and canopy temperature for water stress detection in cereal crops

    NASA Astrophysics Data System (ADS)

    Panigada, C.; Rossini, M.; Meroni, M.; Cilia, C.; Busetto, L.; Amaducci, S.; Boschetti, M.; Cogliati, S.; Picchi, V.; Pinto, F.; Marchesi, A.; Colombo, R.

    2014-08-01

    Narrow-band multispectral remote sensing techniques and thermal imagery were investigated for water stress detection in cereal crops. Visible and near infrared AISA Eagle (Specim, Finland) and thermal AHS-160 (Sensytech Inc., USA) imageries were acquired with an airborne survey on a farm-level experimental site where maize (Zea mays L.) and sorghum (Sorghum bicolor L.) were grown with three different irrigation treatments. Vegetation biophysical and eco-physiological measurements were collected concurrently with the airborne campaign. Leaf fluorescence yield (ΔF/Fm‧) resulted to be a good indirect measure of water stress. Therefore, ΔF/Fm‧ measurements were compared against remotely sensed indicators: (i) the Photochemical Reflectance Index (PRI), (ii) the sun-induced chlorophyll fluorescence at 760 nm (F760), retrieved by the Fraunhofer line depth method and (iii) the canopy temperature (TC) calculated decoupling soil and vegetation contributions. TC was related to ΔF/Fm‧ with the highest determination coefficient (R2 = 0.65), followed by PRI586 (reference band at 586 nm) (R2 = 0.51). The relationship with F760 was significant but weaker (R2 = 0.36). The coefficient of determination increased up to 0.54 when pigment concentration was considered by multiplying ΔF/Fm‧ and chlorophyll content, confirming the close relationship between passive fluorescence signal, pigment content and light photosystem efficiency. PRI586, F760 and TC maps were produced in maize and sorghum plots. The differences in the average values of PRI586, F760 and TC extracted from the plots with different water treatments showed that water treatments were well discriminated in maize plots by the three remotely sensed indicators. This was confirmed by the visual observation of the PRI586, F760 and TC maps, while in sorghum plots, F760 and TC appeared more sensitive to water stress compared to PRI586.

  6. Bilateral symmetry in vision and influence of ocular surgical procedures on binocular vision: A topical review.

    PubMed

    Arba Mosquera, Samuel; Verma, Shwetabh

    2016-01-01

    We analyze the role of bilateral symmetry in enhancing binocular visual ability in human eyes, and further explore how efficiently bilateral symmetry is preserved in different ocular surgical procedures. The inclusion criterion for this review was strict relevance to the clinical questions under research. Enantiomorphism has been reported in lower order aberrations, higher order aberrations and cone directionality. When contrast differs in the two eyes, binocular acuity is better than monocular acuity of the eye that receives higher contrast. Anisometropia has an uncommon occurrence in large populations. Anisometropia seen in infancy and childhood is transitory and of little consequence for the visual acuity. Binocular summation of contrast signals declines with age, independent of inter-ocular differences. The symmetric associations between the right and left eye could be explained by the symmetry in pupil offset and visual axis which is always nasal in both eyes. Binocular summation mitigates poor visual performance under low luminance conditions and strong inter-ocular disparity detrimentally affects binocular summation. Considerable symmetry of response exists in fellow eyes of patients undergoing myopic PRK and LASIK, however the method to determine whether or not symmetry is maintained consist of comparing individual terms in a variety of ad hoc ways both before and after the refractive surgery, ignoring the fact that retinal image quality for any individual is based on the sum of all terms. The analysis of bilateral symmetry should be related to the patients' binocular vision status. The role of aberrations in monocular and binocular vision needs further investigation.

  7. Heavy Metal and Trace Metal Analysis in Soil by Sequential Extraction: A Review of Procedures

    PubMed Central

    Zimmerman, Amanda Jo; Weindorf, David C.

    2010-01-01

    Quantification of heavy and trace metal contamination in soil can be arduous, requiring the use of lengthy and intricate extraction procedures which may or may not give reliable results. Of the many procedures in publication, some are designed to operate within specific parameters while others are designed for more broad application. Most procedures have been modified since their inception which creates ambiguity as to which procedure is most acceptable in a given situation. For this study, the Tessier, Community Bureau of Reference (BCR), Short, Galán, and Geological Society of Canada (GCS) procedures were examined to clarify benefits and limitations of each. Modifications of the Tessier, BCR, and GCS procedures were also examined. The efficacy of these procedures is addressed by looking at the soils used in each procedure, the limitations, applications, and future of sequential extraction. PMID:20414344

  8. 22 CFR 225.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of research involving no more than minimal risk, and for minor changes in approved research. 225.110....110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. (a) The Secretary, HHS, has established, and published as...

  9. 21 CFR 56.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Expedited review procedures for certain kinds of....110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... Food and Drug Administration has established, and published in the Federal Register, a list...

  10. 21 CFR 56.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Expedited review procedures for certain kinds of....110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... Food and Drug Administration has established, and published in the Federal Register, a list...

  11. 21 CFR 56.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Expedited review procedures for certain kinds of....110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... Food and Drug Administration has established, and published in the Federal Register, a list...

  12. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  13. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  14. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  15. Organising Staff to Provide Individual Teaching in a Group: A Critical Review of Room Management and Related Procedures.

    ERIC Educational Resources Information Center

    Sturmey, P.; Crisp, A. G.

    1989-01-01

    The review of the literature on the use of room management (RM) procedures with severely disabled students concluded that RM may be an effective strategy for delivering individual instruction while maintaining high levels of group engagement in other students. RM can reduce problem behaviors and be maintained through positive monitoring and…

  16. 42 CFR 457.1190 - Application of review procedures when States offer premium assistance for group health plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Application of review procedures when States offer premium assistance for group health plans. 457.1190 Section 457.1190 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND...

  17. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  18. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  19. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  20. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  1. 15 CFR Supplement No. 5 to Part 744 - Procedures for End-User Review Committee Entity List Decisions

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Procedures for End-User Review Committee Entity List Decisions No. Supplement No. 5 to Part 744 Commerce and Foreign Trade Regulations... EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED Pt. 744, Supp. 5...

  2. 28 CFR 58.11 - Procedures governing administrative review of a United States Trustee's decision to deny a...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Procedures governing administrative review of a United States Trustee's decision to deny a Chapter 12 or Chapter 13 standing Trustee's claim of actual, necessary expenses. 58.11 Section 58.11 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) REGULATIONS RELATING TO THE...

  3. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... research involving no more than minimal risk, and for minor changes in approved research. 690.110 Section 690.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.110 Expedited review procedures for certain kinds of research involving...

  4. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... research involving no more than minimal risk, and for minor changes in approved research. 690.110 Section 690.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.110 Expedited review procedures for certain kinds of research involving...

  5. 14 CFR 1230.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 1230.110 Section 1230.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION...

  6. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... review procedure shall adopt a method for keeping all members advised of research proposals which have... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides...

  7. 40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.110 Expedited review procedures for certain kinds of research involving no more than minimal... kinds of research involving no more than minimal risk, and for minor changes in approved research....

  8. 40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.110 Expedited review procedures for certain kinds of research involving no more than minimal... kinds of research involving no more than minimal risk, and for minor changes in approved research....

  9. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section...

  10. 45 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved... research involving no more than minimal risk, and for minor changes in approved research. 46.110 Section...

  11. 34 CFR 97.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 97.110 Section 97.110 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS...

  12. 15 CFR 27.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 27.110 Section 27.110 Commerce and Foreign Trade Office of the Secretary of Commerce PROTECTION...

  13. 10 CFR 745.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... adopt a method for keeping all members advised of research proposals which have been approved under the... 10 Energy 4 2011-01-01 2011-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 745.110 Section...

  14. 40 CFR 26.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26... HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.110 Expedited review procedures for certain kinds of research involving no more than...

  15. 10 CFR 745.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... adopt a method for keeping all members advised of research proposals which have been approved under the... 10 Energy 4 2012-01-01 2012-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 745.110 Section...

  16. 10 CFR 745.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... adopt a method for keeping all members advised of research proposals which have been approved under the... 10 Energy 4 2013-01-01 2013-01-01 false Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. 745.110 Section...

  17. 34 CFR 97.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... research involving no more than minimal risk, and for minor changes in approved research. 97.110 Section 97... Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.110 Expedited review procedures for certain kinds of research involving no more than minimal...

  18. 21 CFR 56.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... uses an expedited review procedure shall adopt a method for keeping all members advised of research... research involving no more than minimal risk, and for minor changes in approved research. 56.110 Section 56... of research involving no more than minimal risk, and for minor changes in approved research. (a)...

  19. 16 CFR 1028.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... kinds of research involving no more than minimal risk, and for minor changes in approved research. 1028... HUMAN SUBJECTS § 1028.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. (a) The Secretary, HHS, has...

  20. 28 CFR 46.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... kinds of research involving no more than minimal risk, and for minor changes in approved research. 46... SUBJECTS § 46.110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. (a) The Secretary, HHS, has established,...

  1. 21 CFR 56.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... uses an expedited review procedure shall adopt a method for keeping all members advised of research... research involving no more than minimal risk, and for minor changes in approved research. 56.110 Section 56... of research involving no more than minimal risk, and for minor changes in approved research. (a)...

  2. 22 CFR 225.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of research involving no more than minimal risk, and for minor changes in approved research. 225.110....110 Expedited review procedures for certain kinds of research involving no more than minimal risk, and for minor changes in approved research. (a) The Secretary, HHS, has established, and published as...

  3. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... measure in the NRS. A copy of the list is also available from the U.S. Department of Education, Office of... 34 Education 3 2014-07-01 2014-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department...

  4. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... measure in the NRS. A copy of the list is also available from the U.S. Department of Education, Office of... 34 Education 3 2013-07-01 2013-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department...

  5. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... measure in the NRS. A copy of the list is also available from the U.S. Department of Education, Office of... 34 Education 3 2012-07-01 2012-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department...

  6. 34 CFR 462.12 - What procedures does the Secretary use to review the suitability of tests?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What procedures does the Secretary use to review the suitability of tests? 462.12 Section 462.12 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION...

  7. 29 CFR 37.62 - What are the authority and procedures for conducting pre-approval compliance reviews?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true What are the authority and procedures for conducting pre-approval compliance reviews? 37.62 Section 37.62 Labor Office of the Secretary of Labor IMPLEMENTATION OF THE NONDISCRIMINATION AND EQUAL OPPORTUNITY PROVISIONS OF THE WORKFORCE INVESTMENT ACT OF 1998...

  8. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  9. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under Section 1625 of the Public Health Service Act Appendix to Subpart G of Part 124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  10. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Secretary in Establishing and Implementing Construction Project Agreements § 137.365 What is the procedure... planning standards identified in the construction project agreement. The Secretary shall review and approve design documents for general compliance with requirements of the construction project agreement. (b)...

  11. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Secretary in Establishing and Implementing Construction Project Agreements § 137.365 What is the procedure... planning standards identified in the construction project agreement. The Secretary shall review and approve design documents for general compliance with requirements of the construction project agreement. (b)...

  12. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Secretary in Establishing and Implementing Construction Project Agreements § 137.365 What is the procedure... planning standards identified in the construction project agreement. The Secretary shall review and approve design documents for general compliance with requirements of the construction project agreement. (b)...

  13. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Secretary in Establishing and Implementing Construction Project Agreements § 137.365 What is the procedure... planning standards identified in the construction project agreement. The Secretary shall review and approve design documents for general compliance with requirements of the construction project agreement. (b)...

  14. 42 CFR 137.365 - What is the procedure for the Secretary's review and approval of project planning and design...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Secretary in Establishing and Implementing Construction Project Agreements § 137.365 What is the procedure... planning standards identified in the construction project agreement. The Secretary shall review and approve design documents for general compliance with requirements of the construction project agreement. (b)...

  15. The effectiveness of hypnosis for reducing procedure-related pain in children and adolescents: a comprehensive methodological review.

    PubMed

    Accardi, Michelle C; Milling, Leonard S

    2009-08-01

    A comprehensive, methodologically informed review of studies of the effectiveness of hypnosis for reducing procedure-related pain in children and adolescents is provided. To be included in the review, studies were required to use a between-subjects or mixed model design in which hypnosis was compared with a control condition or an alternative intervention in reducing the procedure-related pain of patients younger than age 19. An exhaustive search identified 13 studies satisfying these criteria. Hypnosis was consistently found to be more effective than control conditions in alleviating discomfort associated with bone marrow aspirations, lumbar punctures, voiding cystourethograms, the Nuss procedure, and post-surgical pain. Furthermore, hypnosis was as at least as effective as distraction. Three hypnotic interventions met criteria as a possibly efficacious empirically supported therapy for reducing post-surgical or lumbar puncture pain. Several other hypnotic interventions would have achieved the status of a possibly efficacious therapy had studies used a treatment manual. PMID:19255840

  16. Antibiotic Prophylaxis for Gynecologic Procedures prior to and during the Utilization of Assisted Reproductive Technologies: A Systematic Review

    PubMed Central

    Hutchinson, Anne P.; Lekovich, Jovana P.; Hobeika, Elie; Elias, Rony T.

    2016-01-01

    The use of assisted reproductive technologies (ART) has increased steadily. There has been a corresponding increase in the number of ART-related procedures such as hysterosalpingography (HSG), saline infusion sonography (SIS), hysteroscopy, laparoscopy, oocyte retrieval, and embryo transfer (ET). While performing these procedures, the abdomen, upper vagina, and endocervix are breached, leading to the possibility of seeding pelvic structures with microorganisms. Antibiotic prophylaxis is therefore important to prevent or treat any procedure-related infections. After careful review of the published literature, it is evident that routine antibiotic prophylaxis is generally not recommended for the majority of ART-related procedures. For transcervical procedures such as HSG, SIS, hysteroscopy, ET, and chromotubation, patients at risk for pelvic infections should be screened and treated prior to the procedure. Patients with a history of pelvic inflammatory disease (PID) or dilated fallopian tubes are at high risk for postprocedural infections and should be given antibiotic prophylaxis during procedures such as HSG, SIS, or chromotubation. Antibiotic prophylaxis is recommended prior to oocyte retrieval in patients with a history of endometriosis, PID, ruptured appendicitis, or multiple prior pelvic surgeries. PMID:27047692

  17. 76 FR 18571 - Notice of Submission of Proposed Information Collection to OMB; Environmental Review Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... Procedures for Entities Assuming HUD Environmental Responsibilities AGENCY: Office of the Chief Information... Assuming HUD Environmental Responsibilities. OMB Approval Number: 2506-0087. Form Numbers:...

  18. 42 CFR 433.120 - Procedures for reduction of FFP after reapproval review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Claims Processing and Information Retrieval Systems § 433.120 Procedures for reduction of FFP after... significance of the unsatisfactory conditions in overall mechanized claims processing and information...

  19. Soft Tissue Infection Caused by Rapid Growing Mycobacterium following Medical Procedures: Two Case Reports and Literature Review

    PubMed Central

    Lin, Shih-Sen; Lee, Chin-Cheng

    2014-01-01

    Non-tubecrulosis mycobacterium infections were increasingly reported either pulmonary or extrapulmonary in the past decades. In Taiwan, we noticed several reports about the soft tissue infections caused by rapid growing mycobacterium such as Mycobacterium abscessus, Mycobacterium chelonae, on newspaper, magazines, or the multimedia. Most of them occurred after a plastic surgery, and medical or non-medical procedures. Here, we reported two cases of these infections following medical procedures. We also discussed common features and the clinical course of the disease, the characteristics of the infected site, and the treatment strategy. The literatures were also reviewed, and the necessity of the treatment guidelines was discussed. PMID:24882980

  20. Tertiary structure mapping of the pri-miRNA miR-17~92.

    PubMed

    Chaulk, Steven G; Fahlman, Richard P

    2014-01-01

    The understanding of RNA in regulating gene expression has exploded over the past 15 years. MicroRNAs (miRNAs) have vastly expanded the role of RNA in gene regulation beyond spliceosomal, ribosomal, and messenger RNAs. Approximately one half of miRNAs are polycistronic, where two or more miRNAs are encoded on a single pri-miRNA transcript, termed a miRNA cluster. The six miRNAs of the miR-17~92 cluster are contained within a ~800 nucleotide region within intron 3 of the cl13orf25 ~7 kb pri-miRNA transcript. We recently reported on the tertiary structured domain of miR-17~92 and its role in modulating miRNA biogenesis. The key finding was that the cluster structure explained the differential processing of the miRNA hairpins by Drosha. This work demonstrated the need to consider pri-miRNA tertiary structure in miRNA biogenesis. Since biochemical structure probing is typically performed on relatively short RNAs (≤200 nucleotides), we had to adapt these methodologies for application on large RNAs (~800 nucleotide miR-17~92 pri-miRNA). We present here our adaptation of a protection footprinting method using ribonucleases to probe the structure of the ~800 nucleotide miR-17~92 pri-miRNA. We outline the technical difficulties involved in probing large RNAs and data visualization using denaturing polyacrylamide gel electrophoresis and how we adapted the existing approaches to probe large RNAs. The methodology outlined here is generally applicable to large RNAs including long noncoding RNAs (lncRNA).

  1. Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio.

    PubMed

    Liebschner, Dorothee; Brzezinski, Krzysztof; Dauter, Miroslawa; Dauter, Zbigniew; Nowak, Marta; Kur, Józef; Olszewski, Marcin

    2012-12-01

    PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the full 220-residue protein, adopts the characteristic oligonucleotide/oligosaccharide-binding (OB) structure consisting of a five-stranded β-barrel filled with hydrophobic residues and equipped with four loops extending from the barrel. In the crystal two protomers dimerize, forming a six-stranded antiparallel β-sheet. The structure of the N-terminal OB domain of T. tengcongensis shows significant differences compared with mesophile PriBs. While in all other known structures of PriB a dimer is formed by two identical OB domains in separate chains, TtePriB contains two consecutive OB domains in one chain. However, sequence comparison of both the N-terminal and the C-terminal domains of TtePriB suggests that they have analogous structures and that the natural protein possesses a structure similar to a dimer of two N-terminal domains.

  2. Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio

    PubMed Central

    Liebschner, Dorothee; Brzezinski, Krzysztof; Dauter, Miroslawa; Dauter, Zbigniew; Nowak, Marta; Kur, Józef; Olszewski, Marcin

    2012-01-01

    PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the full 220-residue protein, adopts the characteristic oligonucleotide/oligosaccharide-binding (OB) structure consisting of a five-stranded β-barrel filled with hydrophobic residues and equipped with four loops extending from the barrel. In the crystal two protomers dimerize, forming a six-stranded antiparallel β-sheet. The structure of the N-terminal OB domain of T. tengcongensis shows significant differences compared with mesophile PriBs. While in all other known structures of PriB a dimer is formed by two identical OB domains in separate chains, TtePriB contains two consecutive OB domains in one chain. However, sequence comparison of both the N-terminal and the C-terminal domains of TtePriB suggests that they have analogous structures and that the natural protein possesses a structure similar to a dimer of two N-terminal domains. PMID:23151633

  3. 24 CFR 15.303 - Procedure for review of demands for production of material or provision of testimony in any legal...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Response to Demands in Legal Proceedings in Which the United States Is a Party § 15.303 Procedure for review of demands for production of material or provision of testimony in any legal proceeding in which... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Procedure for review of demands...

  4. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 435.43 Payload reentry review requirements and... shall apply to the payload reentry review conducted for a license to reenter a reentry vehicle...

  5. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 435.43 Payload reentry review requirements and... shall apply to the payload reentry review conducted for a license to reenter a reentry vehicle...

  6. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 435.43 Payload reentry review requirements and... shall apply to the payload reentry review conducted for a license to reenter a reentry vehicle...

  7. 14 CFR 435.43 - Payload reentry review requirements and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING REENTRY OF A REENTRY VEHICLE OTHER THAN A REUSABLE LAUNCH VEHICLE (RLV) Payload Reentry Review and Determination § 435.43 Payload reentry review requirements and... shall apply to the payload reentry review conducted for a license to reenter a reentry vehicle...

  8. TOPICAL REVIEW: Tritium inventory in ITER plasma-facing materials and tritium removal procedures

    NASA Astrophysics Data System (ADS)

    Roth, Joachim; Tsitrone, Emmanuelle; Loarer, Thierry; Philipps, Volker; Brezinsek, Sebastijan; Loarte, Alberto; Counsell, Glenn F.; Doerner, Russell P.; Schmid, Klaus; Ogorodnikova, Olga V.; Causey, Rion A.

    2008-10-01

    Interactions between the plasma and the vessel walls constitute a major engineering problem for next step fusion devices, such as ITER, determining the choice of the plasma-facing materials. A prominent issue in this choice is the tritium inventory build-up in the vessel, which must be limited for safety reasons. The initial material selection, i.e. beryllium (Be) on the main vessel walls, tungsten (W) on the divertor upper baffle and dome, and carbon fibre composite around the strike points on the divertor plates, results both from the attempt to reduce the tritium inventory and to optimize the lifetime of the plasma-facing components. In the framework of the EU Task Force on Plasma-Wall Interaction (PWI TF), the many physics aspects governing the tritium inventory are brought together. Together with supporting information from international experts represented by the ITPA SOL/DIV section, this paper describes the present status of knowledge of the in-vessel tritium inventory build-up. Firstly, the main results from present fusion devices in this field are briefly reviewed. Then, the processes involved are discussed: implantation, trapping and diffusion in plasma-facing materials are considered as well as surface erosion and co-deposition of tritium with eroded material. The intermixing of the different materials and its influence on hydrogen retention and co-deposition is a major source of uncertainty on present estimates and is also addressed. Based on the previous considerations, estimates for the tritium inventory build-up are given for the initial choice of ITER materials, as well as for alternative options. Present estimates indicate a build-up of the tritium inventory to the administrative limit within a few hundred nominal full power D : T discharges, co-deposition with carbon being the dominant process. Therefore, tritium removal methods are also an active area of research within the EU PWI TF, and are discussed. An integrated operational scheme to slow

  9. Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio

    SciTech Connect

    Liebschner, Dorothee; Brzezinski, Krzysztof; Dauter, Miroslawa; Dauter, Zbigniew; Nowak, Marta; Kur, Józef; Olszewski, Marcin

    2012-12-01

    The N-terminal domain of the PriB protein from the thermophilic bacterium T. tengcongensis (TtePriB) was expressed and its crystal structure has been solved at the atomic resolution of 1.09 Å by direct methods. PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the full 220-residue protein, adopts the characteristic oligonucleotide/oligosaccharide-binding (OB) structure consisting of a five-stranded β-barrel filled with hydrophobic residues and equipped with four loops extending from the barrel. In the crystal two protomers dimerize, forming a six-stranded antiparallel β-sheet. The structure of the N-terminal OB domain of T. tengcongensis shows significant differences compared with mesophile PriBs. While in all other known structures of PriB a dimer is formed by two identical OB domains in separate chains, TtePriB contains two consecutive OB domains in one chain. However, sequence comparison of both the N-terminal and the C-terminal domains of TtePriB suggests that they have analogous structures and that the natural protein possesses a structure similar to a dimer of two N-terminal domains.

  10. Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Lesions: A Systematic Review of Technical and Procedural Variables

    PubMed Central

    Jani, Bhairvi S.; Rzouq, Fadi; Saligram, Shreyas; Lim, Diego; Rastogi, Amit; Bonino, John; Olyaee, Mojtaba

    2016-01-01

    Endoscopic ultrasound (EUS)-guided tissue acquisition has emerged over the last decade as an invaluable diagnostic tool in approaching the different pancreatic lesions. Given the safety and minimal invasiveness of this approach combined with the high diagnostic yield, it became the standard of care when dealing with different pancreatic pathologies. However, some variables regarding this procedure remain not fully understood. These can influence the diagnostic yield of the procedure and include the presence of the on-site cytopathologist, the type and size of the needle used as well as obtaining aspiration versus core biopsy, the number of passes and the sampling technique, and the role of suction and stylet use among others. We performed a comprehensive literature search using PubMed, Google Scholar, and Embase for studies that assessed these variables. Eligible studies were analyzed using several parameters such as technique and procedure, with the aim of reviewing results from an evidence-based standpoint. PMID:27011940

  11. Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Lesions: A Systematic Review of Technical and Procedural Variables.

    PubMed

    Jani, Bhairvi S; Rzouq, Fadi; Saligram, Shreyas; Lim, Diego; Rastogi, Amit; Bonino, John; Olyaee, Mojtaba

    2016-01-01

    Endoscopic ultrasound (EUS)-guided tissue acquisition has emerged over the last decade as an invaluable diagnostic tool in approaching the different pancreatic lesions. Given the safety and minimal invasiveness of this approach combined with the high diagnostic yield, it became the standard of care when dealing with different pancreatic pathologies. However, some variables regarding this procedure remain not fully understood. These can influence the diagnostic yield of the procedure and include the presence of the on-site cytopathologist, the type and size of the needle used as well as obtaining aspiration versus core biopsy, the number of passes and the sampling technique, and the role of suction and stylet use among others. We performed a comprehensive literature search using PubMed, Google Scholar, and Embase for studies that assessed these variables. Eligible studies were analyzed using several parameters such as technique and procedure, with the aim of reviewing results from an evidence-based standpoint.

  12. The efficacy of hypnosis in the reduction of procedural pain and distress in pediatric oncology: a systematic review.

    PubMed

    Wild, Matt R; Espie, Colin A

    2004-06-01

    Children who suffer from cancer have to endure regular, painful medical procedures that are associated with a considerable degree of psychosocial distress. Hypnosis has been successfully employed in the management of pain and distress in the adult population, but is not well studied in pediatric populations. This review systematically evaluates the systematic research conducted in the field of procedure-related pain management in pediatric oncology within the context of a nationally agreed framework for the assessment of research evidence. It is concluded that there is not currently enough robust research evidence to recommend that hypnosis should form part of best practice guidelines for the management of procedure-related pain in pediatric oncology. However, there is sufficient evidence to justify larger-scale, appropriately controlled studies. A number of recommendations are made regarding future research. PMID:15194906

  13. Complication Rates and Patency of Radiologically Guided Mushroom Gastrostomy, Balloon Gastrostomy, and Gastrojejunostomy: A Review of 250 Procedures

    SciTech Connect

    Yip, Doris; Vanasco, Matthew; Funaki, Brian

    2004-01-15

    To compare complication rates and tube performance of percutaneous mushroom gastrostomy, balloon gastrostomy, and gastrojejunostomy. Between September 9, 1999 and April 23, 2001, 203 patients underwent 250 radiologically guided percutaneous gastrostomy and gastrojejunostomy procedures. Follow-up was conducted through chart reviews and review of our interventional radiology database. Procedural and catheter-related complications were recorded. Chi-square statistical analysis was performed. In patients receiving mushroom-retained gastrostomy catheters (n = 114), the major complication rate was 0.88% (n = 1), the minor complication rate was 5.3% (n = 6), and the tube complication rate was 4.4% (n = 5). In patients receiving balloon-retained gastrostomy tubes (n = 67), the major complication rate was 0, the minor complication rate was 4.5% (n = 3), and the tube complication rate was 34.3% (n = 23). In patients receiving gastrojejunostomy catheters (n = 69), the major complication rate was 1.4% (n = 1), the minor complication rate was 2.9% (n = 2), and the tube complication rate was 34.8% (n = 24). No statistically significant differences were found between procedural or peri-procedural complications among the different types of tubes. Mushroom-retained catheters had significantly fewer tube complications (p < 0.01). Percutaneous gastrostomy and gastrojejunostomy have similar procedural and peri-procedural complication rates. Mushroom gastrostomy catheters have fewer tube-related complications compared with balloon gastrostomy and gastrojejunostomy catheters. In addition, mushroom-retained catheters exhibit the best overall long-term tube patency and are therefore the gastrostomy catheter of choice.

  14. Recurrent anterior shoulder instability: a review of the Latarjet procedure and its postoperative rehabilitation.

    PubMed

    Fedorka, Catherine J; Mulcahey, Mary K

    2015-02-01

    The shoulder is the most common joint to dislocate in the human body, with the dislocation often occurring in the anterior direction. This injury frequently results in soft tissue injury (eg, labral tear, capsular stretching) or bone injury (eg, glenoid or humeral head bone loss), which commonly leads to persistent deficits of shoulder function and a high risk of subsequent instability episodes in young, active patients. Patients with a significant degree of glenoid bone loss (> 25%) may require surgical intervention using the Latarjet procedure, which is an open bony augmentation of the glenoid. This procedure involves transferring the tip of the coracoid to the anteroinferior glenoid, creating a bony block and musculotendinous sling to prevent instability. Rehabilitation after the procedure is a slow progression over 4 to 6 months to regain range of motion and strength, while protecting the bony augmentation. Recent reports have shown success with the Latarjet procedure, as indicated by patient satisfaction scores and a low rate of recurrent instability.

  15. Suprascapular nerve palsy after arthroscopic Latarjet procedure: a case report and review of literature.

    PubMed

    Sastre, Sergi; Peidro, Lluis; Méndez, Anna; Calvo, Emilio

    2016-02-01

    The Bristow and Latarjet procedures have become popular among orthopaedic surgeons thanks to the development of new instruments that allow the use of arthroscopic techniques to treat cases of glenohumeral instability with bone defects or capsular deficiency. Nonetheless, several complications have been reported after Latarjet procedures, including neurological injuries. This report describes surgical damage to the suprascapular nerve, an unusual complication. Level of evidence Expert opinion, Level V.

  16. The Combination Therapy of Dissolution Using Carbonated Liquid and Endoscopic Procedure for Bezoars: Pragmatical and Clinical Review

    PubMed Central

    Ogawa, Kohei; Mizuno, Ken-ichi; Shinagawa, Yoko; Kobayashi, Yuji; Abe, Hiroyuki; Watanabe, Yukari; Takahashi, Shunsaku; Hayashi, Kazunao; Yokoyama, Junji; Takeuchi, Manabu; Yamagiwa, Satoshi; Sato, Yuichi; Terai, Shuji

    2016-01-01

    Bezoars are relatively rare foreign bodies of gastrointestinal tract and often cause ileus and ulcerative lesions in the stomach and subsequent bleeding and perforation due to their size and stiffness. Therefore, the removal of bezoars is essential and recent development of devices, the endoscopic removal procedure, is often applied. However, due to their stiffness, simple endoscopic removal failed in not a few cases, and surgical removal has also been used. Recently, the efficacy of a combination therapy of endoscopic procedure and dissolution using carbonated liquid has been reported. To develop the safe and effective removal procedure, we carefully reviewed a total of 55 reported cases in this study including our 3 additional cases, successfully treated with dissolution with endoscopic fragmentation. In summary, the data showed the efficiency in the combination therapy, treating the larger size of bezoar and reducing the length of hospital stay. To the best of our knowledge, this is the largest pragmatical and clinical review for the combination therapy of dissolution and endoscopic treatment for bezoars. This review should help physicians to manage bezoars more efficiently.

  17. The Combination Therapy of Dissolution Using Carbonated Liquid and Endoscopic Procedure for Bezoars: Pragmatical and Clinical Review

    PubMed Central

    Ogawa, Kohei; Mizuno, Ken-ichi; Shinagawa, Yoko; Kobayashi, Yuji; Abe, Hiroyuki; Watanabe, Yukari; Takahashi, Shunsaku; Hayashi, Kazunao; Yokoyama, Junji; Takeuchi, Manabu; Yamagiwa, Satoshi; Sato, Yuichi; Terai, Shuji

    2016-01-01

    Bezoars are relatively rare foreign bodies of gastrointestinal tract and often cause ileus and ulcerative lesions in the stomach and subsequent bleeding and perforation due to their size and stiffness. Therefore, the removal of bezoars is essential and recent development of devices, the endoscopic removal procedure, is often applied. However, due to their stiffness, simple endoscopic removal failed in not a few cases, and surgical removal has also been used. Recently, the efficacy of a combination therapy of endoscopic procedure and dissolution using carbonated liquid has been reported. To develop the safe and effective removal procedure, we carefully reviewed a total of 55 reported cases in this study including our 3 additional cases, successfully treated with dissolution with endoscopic fragmentation. In summary, the data showed the efficiency in the combination therapy, treating the larger size of bezoar and reducing the length of hospital stay. To the best of our knowledge, this is the largest pragmatical and clinical review for the combination therapy of dissolution and endoscopic treatment for bezoars. This review should help physicians to manage bezoars more efficiently. PMID:27642293

  18. The Combination Therapy of Dissolution Using Carbonated Liquid and Endoscopic Procedure for Bezoars: Pragmatical and Clinical Review.

    PubMed

    Ogawa, Kohei; Kamimura, Kenya; Mizuno, Ken-Ichi; Shinagawa, Yoko; Kobayashi, Yuji; Abe, Hiroyuki; Watanabe, Yukari; Takahashi, Shunsaku; Hayashi, Kazunao; Yokoyama, Junji; Takeuchi, Manabu; Kobayashi, Masaaki; Yamagiwa, Satoshi; Sato, Yuichi; Terai, Shuji

    2016-01-01

    Bezoars are relatively rare foreign bodies of gastrointestinal tract and often cause ileus and ulcerative lesions in the stomach and subsequent bleeding and perforation due to their size and stiffness. Therefore, the removal of bezoars is essential and recent development of devices, the endoscopic removal procedure, is often applied. However, due to their stiffness, simple endoscopic removal failed in not a few cases, and surgical removal has also been used. Recently, the efficacy of a combination therapy of endoscopic procedure and dissolution using carbonated liquid has been reported. To develop the safe and effective removal procedure, we carefully reviewed a total of 55 reported cases in this study including our 3 additional cases, successfully treated with dissolution with endoscopic fragmentation. In summary, the data showed the efficiency in the combination therapy, treating the larger size of bezoar and reducing the length of hospital stay. To the best of our knowledge, this is the largest pragmatical and clinical review for the combination therapy of dissolution and endoscopic treatment for bezoars. This review should help physicians to manage bezoars more efficiently. PMID:27642293

  19. Comparison of the Predictive Validity and Consistency among Preference Assessment Procedures: A Review of the Literature

    ERIC Educational Resources Information Center

    Kang, Soyeon; O'Reilly, Mark; Lancioni, Giulio; Falcomata, Terry S.; Sigafoos, Jeff; Xu, Ziwei

    2013-01-01

    We reviewed 14 experimental studies comparing different preference assessments for individuals with developmental disabilities that were published in peer-reviewed journals between 1985 and 2012. Studies were summarized based on the following six variables: (a) the number of participants, (b) the type of disability, (c) the number and type of…

  20. Review of Measurement Instruments and Procedures for Assessing Visual Behaviors: Implications for Quantitative Measurement.

    ERIC Educational Resources Information Center

    Janssen, Cynthia M.

    The assessment of vision as it relates to and interacts with motor development is reviewed. The focus is on eye readiness skills normally occuring in infants' first few months of life and preceding eye-hand coordination. These visual skills fall into three categories: fixation, tracking, and scanning. Six standardized scales are reviewed and…

  1. Regional anesthesia or patient-controlled analgesia and compartment syndrome in orthopedic surgical procedures: a systematic review

    PubMed Central

    Driscoll, Elizabeth BS; Maleki, Ana Hosseinzadeh; Jahromi, Leila; Hermecz, Brittany Nelson; Nelson, Lauren E; Vetter, Imelda L; Evenhuis, Spencer; Riesenberg, Lee Ann

    2016-01-01

    A systematic review of the literature on the use of regional anesthesia (RA) and patient-controlled analgesia (PCA) was conducted in patients who require orthopedic extremity procedures to determine whether either analgesic technique contributes to a delayed diagnosis of compartment syndrome (CS). A total of 34 relevant articles (28 case reports and six research articles) were identified. Of all case report articles published after 2009, the majority (75%) concluded that RA does not put the patient at an increased risk of a delayed diagnosis of CS. Of these, only two relevant prospective research studies focusing on RA or PCA and their relationship to CS were identified. Neither study resulted in any cases of CS. However, both had relatively small sample sizes. Given the lack of evidence identified in this systematic review, prospective studies or large-scale retrospective data reviews are needed to more strongly advocate the use of one modality of analgesia over the other in this patient population. PMID:27785097

  2. Evaluation of DSS-14 pedestal-review of top surface repair procedures

    NASA Technical Reports Server (NTRS)

    Oesterle, R. G.; Musser, D. W.; Salse, E. A. B.

    1983-01-01

    Proposed repair procedures for the top surface of the pedestal supporting the hydrostatic bearing runner for the 64m Antenna are presented. These procedures included: (1) removal of existing grout and concrete to approximately 8 in. below original concrete surface using a presplitting technique with expansive cement followed by secondary breaking; (2) preparation of exposed concrete surface including an epoxy bonding agent; and (3) replacement of material removed with 8 in. of new concrete surface including an epoxy bonding agent; and (4) replacement of material removed with 8 in. of new concrete and 4 in. of new grout.

  3. Long-Term Memory: A Review and Meta-Analysis of Studies of Declarative and Procedural Memory in Specific Language Impairment

    ERIC Educational Resources Information Center

    Lum, Jarrad A. G.; Conti-Ramsden, Gina

    2013-01-01

    This review examined the status of long-term memory systems in specific language impairment (SLI)--declarative memory and aspects of procedural memory in particular. Studies included in the review were identified following a systematic search of the literature and findings combined using meta-analysis. This review showed that individuals with SLI…

  4. 16 CFR 1021.7 - Coordination of environmental review with CPSC procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CPSC procedures. 1021.7 Section 1021.7 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL... decisionmaking process. (c) Draft EISs or findings of no significant impact together with environmental.... Pursuant to § 1506.10 of the NEPA regulations, no decision on a proposed action shall be made by...

  5. 46 CFR Appendix C to Part 404 - Procedures for Annual Review of Base Pilotage Rates

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...; Step 6: Divide the result in Step 5 by projected bridge hours to determine total unit costs; Step 7... period rates by the percentage change in unit costs in Step 7. For example if the total economic costs... coordination with Canada using the following procedures: Step 1: Calculate the total economic costs for...

  6. Information Exchange Procedures Manual (Field Review Edition): A Synopsis. Technical Report No. 46.

    ERIC Educational Resources Information Center

    Romney, Leonard C.

    The purpose of the Information Exchange Procedures (IEP) projects is to create among higher education institutions the capability for exchanging and reporting that information, both financial and otherwise, necessary to calculate and evaluate costs (1) by discipline and course level and (2) by student program and student level. Most uses of…

  7. Teaching Spelling through Prompting and Review Procedures Using Computer-Based Instruction

    ERIC Educational Resources Information Center

    Mayfield, Kristin H.; Glenn, Irene M.; Vollmer, Timothy R.

    2008-01-01

    Computer-based instruction (CBI) was used to teach 3 sets of 20 spelling words to two 6th graders in a multiple baseline design. The CBI presented a voice recording of each spelling word and prompted the students to type the word. If they spelled the word incorrectly, a training procedure was initiated that included prompt fading and systematic…

  8. 76 FR 31225 - Procedures Governing Administrative Review of a United States Trustee's Decision To Deny a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... August 14, 2009, at 74 FR 41,101, EOUST ] published a proposed rule on this topic. Before the comment... To Deny a Chapter 12 or Chapter 13 Standing Trustee's Claim of Actual, Necessary Expenses AGENCY... rule (``rule'') sets forth the procedures for a chapter 12 or chapter 13 standing trustee...

  9. 34 CFR 303.342 - Procedures for IFSP development, review, and evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND TODDLERS WITH DISABILITIES Program and Service Components of a Statewide System of Early Intervention Services Individualized Family Service Plans (ifsps) § 303.342 Procedures for...

  10. 10 CFR 1010.203 - Procedures for review and approval of requests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... EMPLOYEES Procedures for Exemption of Scientific and Technological Information Communications From Post...), (c), and (d) who wishes to communicate scientific or technological information to DOE must contact... and DOE; (3) The nature of the scientific or technological information to be conveyed; (4) The...

  11. Community College Grievance Procedures: A Review of Contract Content in Ninety-Four Colleges

    ERIC Educational Resources Information Center

    Mannix, Thomas

    1974-01-01

    After examining grievance procedures of community colleges, the author compares the range of differences on specific aspects of the contractual arrangement for 94 community colleges as to the type of arbitration, type of grievance, time limit, agent, expiration, grievance definition, and limitation of arbitration. (Editor/PG)

  12. Review of State Policies Concerning the Use of Physical Restraint Procedures in Schools

    ERIC Educational Resources Information Center

    Ryan, Joseph B.; Robbins, Katherine; Peterson, Reece; Rozalski, Michael

    2009-01-01

    Recent injuries and fatalities among students due to the use of physical restraint procedures in schools, and the resulting media attention and litigation have started to place pressure on many state and local education agencies to develop policies or guidelines concerning their use in schools. The authors investigated existing state policies and…

  13. 76 FR 26302 - Submission for OMB Review; Comment Request; Reunification Procedures for Unaccompanied Alien...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ...; Reunification Procedures for Unaccompanied Alien Children Description Following the passage of the 2002 Homeland... Resettlement (ORR), is charged with the care and placement of unaccompanied alien children in Federal custody... unaccompanied alien. Annual Burden Estimates Number of Average Instrument Number of responses per burden...

  14. Corralling Your Camp Horse Program: Reviewing Your Policies and Procedures and Creating a Written Manual.

    ERIC Educational Resources Information Center

    Glunt, Jim

    2000-01-01

    Camps offering horse programs need to have written policies and procedures to ensure quality control and risk minimization. Basic elements of a horse program manual include routine care of horses; general guidelines relating to participants, program, and staff; and emergency plans. Four information resources are presented. (TD)

  15. Remote detection of water stress conditions via a diurnal photochemical reflectance index (PRI) improves yield prediction in rainfed wheat

    NASA Astrophysics Data System (ADS)

    Magney, T. S.; Vierling, L. A.; Eitel, J.

    2014-12-01

    Employing remotely sensed techniques to quantify the existence and magnitude of midday photosynthetic downregulation using the photochemical reflectance index (PRI) may reveal new information about plant responses to abiotic stressors in space and time. However, the interpretation and application of the PRI can be confounded because of its sensitivity to several variables changing at the diurnal (e.g., irradiation, shadow fraction) and seasonal (e.g., leaf area, chlorophyll and carotene pigment concentrations, irradiation) time scales. We explored different techniques to correct the PRI for variations in canopy structure and relative chlorophyll content (ChlR) using highly temporally resolved (frequency = five minutes) in-situ radiometric measurements of PRI and the Normalized Difference Vegetation Index (NDVI) over eight soft white spring wheat (Triticum aestivum L.)field plots under varying nitrogen and soil water conditions over two seasons. Our results suggest that the influence of seasonal variation in canopy ChlR and LAI on the diurnally measured PRI (PRIdiurnal) can be minimized using simple correction techniques, therefore improving the strength of PRI as a tool to quantify abiotic stressors such as daily changes in soil volumetric water content (SVWC), and vapor pressure deficit (VPD). PRIdiurnal responded strongly to available nitrogen, and linearly tracked seasonal changes in SVWC, VPD, and stomatal conductance (gc). Utilizing the PRI as an indicator of stress, yield predictions significantly over greenness indices such as the NDVI. This study provides insight towards the future interpretation and scaling of PRI to quantify rapid changes in photosynthesis, and as an indicator of plant stress.

  16. 34 CFR 222.158 - What procedures apply to the Secretary's review of an initial decision?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION IMPACT AID PROGRAMS Impact Aid Administrative Hearings and Judicial Review Under Section 8011 of the Act § 222.158...

  17. 78 FR 30733 - Modernizing Federal Infrastructure Review and Permitting Regulations, Policies, and Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... best-management practices. These best-management practices include: integrating project reviews among..., including navigational channels; water resources projects; renewable energy generation; conventional energy... protection and continued enjoyment of our Nation's environmental, historical, and cultural resources...

  18. Essential role of the iron-sulfur cluster binding domain of the primase regulatory subunit Pri2 in DNA replication initiation.

    PubMed

    Liu, Lili; Huang, Mingxia

    2015-03-01

    DNA primase catalyzes de novo synthesis of a short RNA primer that is further extended by replicative DNA polymerases during initiation of DNA replication. The eukaryotic primase is a heterodimeric enzyme comprising a catalytic subunit Pri1 and a regulatory subunit Pri2. Pri2 is responsible for facilitating optimal RNA primer synthesis by Pri1 and mediating interaction between Pri1 and DNA polymerase α for transition from RNA synthesis to DNA elongation. All eukaryotic Pri2 proteins contain a conserved C-terminal iron-sulfur (Fe-S) cluster-binding domain that is critical for primase catalytic activity in vitro. Here we show that mutations at conserved cysteine ligands for the Pri2 Fe-S cluster markedly decrease the protein stability, thereby causing S phase arrest at the restrictive temperature. Furthermore, Pri2 cysteine mutants are defective in loading of the entire DNA pol α-primase complex onto early replication origins resulting in defective initiation. Importantly, assembly of the Fe-S cluster in Pri2 is impaired not only by mutations at the conserved cysteine ligands but also by increased oxidative stress in the sod1Δ mutant lacking the Cu/Zn superoxide dismutase. Together these findings highlight the critical role of Pri2's Fe-S cluster domain in replication initiation in vivo and suggest a molecular basis for how DNA replication can be influenced by changes in cellular redox state.

  19. The Criminal Procedure (Insanity and Unfitness to Plead) Act, 1991. A case report and selected review of the legal reforms.

    PubMed

    Dolan, M C; Campbell, A A

    1994-04-01

    Procedures relating to Insanity and Fitness to Plead are reviewed with special emphasis on the problems encountered with previous legislation. The introduction of the new Criminal Procedure (Insanity and Unfitness to Plead) Act 1991, on 1 January 1992, offered greater discretion in the disposal of these defendants, but fell short of many of the recommendations made by those advocating reform. As yet, too few cases have passed through the courts to highlight particular deficiencies in the unreformed parts of the Act, but the benefits are already apparent. Finally, some of the potential pitfalls of supervision and treatment orders and other disposals are discussed and an insanity case, dealt with under the new legislation, is presented.

  20. Incidence of adverse events in paediatric procedural sedation in the emergency department: a systematic review and meta-analysis

    PubMed Central

    Bellolio, M Fernanda; Puls, Henrique A; Anderson, Jana L; Gilani, Waqas I; Murad, M Hassan; Barrionuevo, Patricia; Erwin, Patricia J; Wang, Zhen; Hess, Erik P

    2016-01-01

    Objective and design We conducted a systematic review and meta-analysis to evaluate the incidence of adverse events in the emergency department (ED) during procedural sedation in the paediatric population. Randomised controlled trials and observational studies from the past 10 years were included. We adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Setting ED. Participants Children. Interventions Procedural sedation. Outcomes Adverse events like vomiting, agitation, hypoxia and apnoea. Meta-analysis was performed with random-effects model and reported as incidence rates with 95% CIs. Results A total of 1177 studies were retrieved for screening and 258 were selected for full-text review. 41 studies reporting on 13 883 procedural sedations in 13 876 children (≤18 years) were included. The most common adverse events (all reported per 1000 sedations) were: vomiting 55.5 (CI 45.2 to 65.8), agitation 17.9 (CI 12.2 to 23.7), hypoxia 14.8 (CI 10.2 to 19.3) and apnoea 7.1 (CI 3.2 to 11.0). The need to intervene with either bag valve mask, oral airway or positive pressure ventilation occurred in 5.0 per 1000 sedations (CI 2.3 to 7.6). The incidences of severe respiratory events were: 34 cases of laryngospasm among 8687 sedations (2.9 per 1000 sedations, CI 1.1 to 4.7; absolute rate 3.9 per 1000 sedations), 4 intubations among 9136 sedations and 0 cases of aspiration among 3326 sedations. 33 of the 34 cases of laryngospasm occurred in patients who received ketamine. Conclusions Serious adverse respiratory events are very rare in paediatric procedural sedation in the ED. Emesis and agitation are the most frequent adverse events. Hypoxia, a late indicator of respiratory depression, occurs in 1.5% of sedations. Laryngospasm, though rare, happens most frequently with ketamine. The results of this study provide quantitative risk estimates to facilitate shared decision-making, risk communication, informed consent and

  1. Removal of Review and Reclassification Procedures for Biological Products Licensed Prior to July 1, 1972. Final rule.

    PubMed

    2016-02-12

    The Food and Drug Administration (FDA, the Agency, or we) is removing two regulations that prescribe procedures for FDA's review and classification of biological products licensed before July 1, 1972. FDA is taking this action because the two regulations are obsolete and no longer necessary in light of other statutory and regulatory authorities established since 1972, which allow FDA to evaluate and monitor the safety and effectiveness of all biological products. In addition, other statutory and regulatory authorities authorize FDA to revoke a license for biological products because they are not safe and effective, or are misbranded. FDA is taking this action as part of its retrospective review of its regulations to promote improvement and innovation. PMID:26878738

  2. Response to the independent technical review of the UMTRA Project procedures and practices for well drilling and development

    SciTech Connect

    Not Available

    1994-07-01

    This report is a response to the findings and recommendations contained in the ITR report. The text of this document summarizes each ITR finding and recommendation, presents the TAC response, and concludes that implementation of many of the recommendations would benefit the UMTRA Project. Implementation of the recommendations represents ongoing improvement to the TAC well installation and development procedures and will result, in lower overall project costs. Appendix B is an implementation plan that groups similar or complementary action items, provides a schedule for implementation, identifies the group or people responsible for the changes, and estimates hours to implement the changes. The four major action items are as follows: (1) ITR Reevaluation, (2) Well Installation SOP Review and Revision, (3) Well Installation Contract Review and Revision, and (4) TAC and DOE Communications Improvement. The hours listed to implement the improvements are intended to be estimates for budgeting and planning purposes for the remainder of this fiscal year and the upcoming fiscal year.

  3. 24 CFR 55.10 - Environmental review procedures under 24 CFR parts 50 and 58.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under 24 CFR parts 50 and 58. 55.10 Section 55.10 Housing and Urban Development Office of the Secretary... under 24 CFR parts 50 and 58. (a) Where an environmental review is required under the National Environmental Policy Act of 1969 (NEPA) (42 U.S.C. 4321 et seq.), and 24 CFR part 50 or part 58, compliance...

  4. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) State whether it believes that additional data are needed and, if so, describe what is needed. A FIFRA 3(c)(2)(B) notice requiring such data may be issued in conjunction with a proposed or final decision... remain open until all actions required in the final decision on the registration review case have...

  5. 49 CFR 194.121 - Response plan review and update procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SAFETY RESPONSE PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.121 Response plan review and update... as a change from crude oil to gasoline; (4) The name of the oil spill removal organization; (5....121 Section 194.121 Transportation Other Regulations Relating to Transportation (Continued)...

  6. 49 CFR 194.121 - Response plan review and update procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SAFETY RESPONSE PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.121 Response plan review and update... as a change from crude oil to gasoline; (4) The name of the oil spill removal organization; (5....121 Section 194.121 Transportation Other Regulations Relating to Transportation (Continued)...

  7. 49 CFR 194.121 - Response plan review and update procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY RESPONSE PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.121 Response plan review and update... as a change from crude oil to gasoline; (4) The name of the oil spill removal organization; (5....121 Section 194.121 Transportation Other Regulations Relating to Transportation (Continued)...

  8. 49 CFR 194.121 - Response plan review and update procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAFETY RESPONSE PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.121 Response plan review and update... as a change from crude oil to gasoline; (4) The name of the oil spill removal organization; (5....121 Section 194.121 Transportation Other Regulations Relating to Transportation (Continued)...

  9. 49 CFR 194.121 - Response plan review and update procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SAFETY RESPONSE PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.121 Response plan review and update... as a change from crude oil to gasoline; (4) The name of the oil spill removal organization; (5....121 Section 194.121 Transportation Other Regulations Relating to Transportation (Continued)...

  10. Review of Measurement Instruments and Procedures for Assessing Mobility Behaviors: Implications for Quantitative Measurement.

    ERIC Educational Resources Information Center

    Lehr, Donna H.

    The literature review identifies information regarding the emergence of mobility skills in infants and young handicapped children, including rolling, crawling, creeping, and walking. Sections discuss the following topics: assessment instruments relevant to mobility, the identification of developmental milestones in mobility, and a hierarchy of the…

  11. 15 CFR 923.133 - Procedure for conducting continuing reviews of approved State CZM programs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... approved CZM program; (B) The management agency is effectively playing a leadership role in coastal issues..., DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS... performance of coastal States with respect to coastal management. Each review shall include a...

  12. 15 CFR 923.133 - Procedure for conducting continuing reviews of approved State CZM programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... approved CZM program; (B) The management agency is effectively playing a leadership role in coastal issues..., DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS... performance of coastal States with respect to coastal management. Each review shall include a...

  13. 15 CFR 923.133 - Procedure for conducting continuing reviews of approved State CZM programs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... approved CZM program; (B) The management agency is effectively playing a leadership role in coastal issues..., DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS... performance of coastal States with respect to coastal management. Each review shall include a...

  14. 15 CFR 923.133 - Procedure for conducting continuing reviews of approved State CZM programs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... approved CZM program; (B) The management agency is effectively playing a leadership role in coastal issues..., DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS... performance of coastal States with respect to coastal management. Each review shall include a...

  15. Perianesthetic Mortality in Domestic Animals: A Retrospective Study of Postmortem Lesions and Review of Autopsy Procedures.

    PubMed

    DeLay, J

    2016-09-01

    Autopsy of animals that die in the perianesthetic period allows identification of anesthetic and surgical complications as well as preexisting disease conditions that may have contributed to mortality. In most studies to date investigating perianesthetic mortality in animals, inclusion of autopsy data is very limited. This retrospective study evaluated autopsy findings in 221 cases of perianesthetic death submitted to a veterinary diagnostic laboratory from primary care and referral hospitals. Canine (n = 105; 48%) and feline (n = 90; 41%) cases predominated in the study, involving elective (71%) and emergency (19%) procedures. The clinical history provided to the pathologist was considered incomplete in 42 of 221 cases (19%), but this history was considered essential for evaluating the circumstances of perianesthetic death. Disease had been recognized clinically in 69 of 221 animals (31%). Death occurred in the premedication or sedation (n = 19; 9%), induction (n = 22; 11%), or maintenance (n = 73; 35%) phases or in the 24 hours postanesthesia (n = 93 animals; 45%). Lesions indicative of significant natural disease were present in 130 of 221 animals (59%), mainly involving the heart, upper respiratory tract, or lungs. Surgical or anesthesia-associated complications were identified in 10 of 221 cases (5%). No lesions were evident in 80 of 221 animals (36%), the majority of which were young, healthy, and undergoing elective surgical procedures. Lesions resulting from cardiopulmonary resuscitation were identified in 75 of 221 animals (34%). Investigation of perianesthetic death cases should be done with knowledge of prior clinical findings and antemortem surgical and medical procedures; the autopsy should particularly focus on the cardiovascular and respiratory system, including techniques to identify pneumothorax and venous air embolism. PMID:27371539

  16. STS-55 SL-D2 crew reviews preflight CEIT procedures in KSC conference room

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Spacelab Deutsche 2 (SL-D2) crewmembers, seated at a conference table, discuss Crew Equipment Interface Test (CEIT) procedures in a briefing room at the Kennedy Space Center (KSC). From left are Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross, German Payload Specialist 1 Ulrich Walter, Pilot Terence T. Henricks, Commander Steven R. Nagel, MS3 Bernard J. Harris, Jr, German Payload Specialist 2 Hans Schlegel, and MS2 Charles J. Precourt. Seated in the foreground are KSC technicians and payload integration officers. Walter and Schlegel are representatives from DLR. View provided by KSC with alternate KSC number KSC-93PC-212.

  17. Review of the design and manufacturing procedures for large-format holographic optical elements

    NASA Astrophysics Data System (ADS)

    Stojanoff, Christo G.; Schuette, Hartmut; Schulat, Jochen; Froning, Philipp

    1998-10-01

    The objective of this research program was the development of the technology for the industrial manufacturing of HOEs for technical applications such as: holographic solar concentrators for utilization in photovoltaic energy conversion and solar photochemistry, and integrated holographic stacks for daylighting, glazing and shading in buildings. Some of the fabricated HOEs exhibit apertures in the order of 8 square meters. The accomplished technology facilitates the continuous fabrication of the holographic films on glass or plastic substrata. The standard holographic material we use for the fabrication of HOEs is dichromated gelatin (DCG) on glass or plastic film (PET) substrata. The dichromated gelatin layer could be prepared with different compositions to accommodate the desired exposures and chemical processing procedures. At present we manufacture holographic plates on glass substrata in sizes of up to 1 meter square. The holographic film on plastic substratum is 20 cm wide and could be made in lengths of hundredths of meters. The inexpensive fabrication of such large formats is attained by automation of the entire process: film manufacturing, hologram copying, development and test. We present in this paper the design considerations and the developed manufacturing procedures. These comprise the fabrication of large format reflective holograms for concentrating mirrors and the copying of transmissive holograms, such as gratings and lenses, using in-plane contact copying in checkerboard arrangement or rotating drum continuous copying onto an endless plastic film.

  18. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Procedures for administrative review of a determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURE AND...

  19. Review of experimental attempts of islet allotransplantation in rodents: parameters involved and viability of the procedure.

    PubMed

    Iuamoto, Leandro Ryuchi; Meyer, Alberto; Chaib, Eleazar; D'Albuquerque, Luiz Augusto Carneiro

    2014-10-01

    The purpose of the present study was to organize the parameters involved in experimental allotransplantation in rodents to elaborate the most suitable model to supply the scarcity of islet donors. We used the PubMed database to systematically search for published articles containing the keywords "rodent islet transplantation" to review. We included studies that involved allotransplantation experiments with rodents' islets, and we reviewed the reference lists from the eligible publications that were retrieved. We excluded articles related to isotransplantation, autotransplantation and xenotransplantation, i.e., transplantation in other species. A total of 25 studies related to allotransplantation were selected for systematic review based on their relevance and updated data. Allotransplantation in rodents is promising and continues to develop. Survival rates of allografts have increased with the discovery of new immunosuppressive drugs and the use of different graft sites. These successes suggest that islet transplantation is a promising method to overcome the scarcity of islet donors and advance the treatment options for type 1 diabetes. PMID:25309081

  20. mirTarPri: Improved Prioritization of MicroRNA Targets through Incorporation of Functional Genomics Data

    PubMed Central

    Li, Ronghong; Ye, Jingrun; Zhao, Zuxianglan; Li, Yan; Huang, Teng; Li, Xia

    2013-01-01

    MicroRNAs (miRNAs) are a class of small (19–25 nt) non-coding RNAs. This important class of gene regulator downregulates gene expression through sequence-specific binding to the 3′untranslated regions (3′UTRs) of target mRNAs. Several computational target prediction approaches have been developed for predicting miRNA targets. However, the predicted target lists often have high false positive rates. To construct a workable target list for subsequent experimental studies, we need novel approaches to properly rank the candidate targets from traditional methods. We performed a systematic analysis of experimentally validated miRNA targets using functional genomics data, and found significant functional associations between genes that were targeted by the same miRNA. Based on this finding, we developed a miRNA target prioritization method named mirTarPri to rank the predicted target lists from commonly used target prediction methods. Leave-one-out cross validation has proved to be successful in identifying known targets, achieving an AUC score up to 0. 84. Validation in high-throughput data proved that mirTarPri was an unbiased method. Applying mirTarPri to prioritize results of six commonly used target prediction methods allowed us to find more positive targets at the top of the prioritized candidate list. In comparison with other methods, mirTarPri had an outstanding performance in gold standard and CLIP data. mirTarPri was a valuable method to improve the efficacy of current miRNA target prediction methods. We have also developed a web-based server for implementing mirTarPri method, which is freely accessible at http://bioinfo.hrbmu.edu.cn/mirTarPri. PMID:23326485

  1. Racial/ethnic differences in health care utilization of cardiovascular procedures: a review of the evidence.

    PubMed

    Ford, E S; Cooper, R S

    1995-04-01

    Studies based on a variety of primary data sets have consistently demonstrated that African Americans are about half as likely as whites to receive interventional therapy for coronary artery disease. Neither disease severity per se nor access to hospitals performing these procedures accounts for this finding. Likewise, available measures of income and ability to pay, including insurance status, do not explain the differences. Subtle personal factors, including physician bias and the willingness of patients to accept referral for surgery, may be important but have not as yet been measured. These findings present a challenge to the presumed equality in access to health care within the United States medical system. A new generation of health services research studies will be required to provide definitive reasons for this important disparity in treatment.

  2. A focused review on acne-induced and aesthetic procedure-related postinflammatory hyperpigmentation in Asians.

    PubMed

    Eimpunth, S; Wanitphadeedecha, R; Manuskiatti, W

    2013-01-01

    Postinflammatory hyperpigmentation (PIH) is a common consequence following cutaneous inflammation in dark-skinned individuals with Fitzpatrick skin phototypes (SPTs) III-VI. The exact pathogenesis of this condition is unknown, but is believed to be an integral part of the normal response of the skin to inflammatory stimuli. PIH can last from months to years and may significantly impair quality of life of affected individuals. The primary treatment of PIH is prevention and treatment of the underlying inflammatory condition. In addition to prevention, there are a variety of medication and procedures used to treat PIH. Although topical skin-depigmenting agents remain the treatment of choice for PIH, lasers and light sources may be an effective adjunctive therapy or alternative for treatment failures. When treating PIH, any treatment options selected should be optimized and utilized carefully because the treatments itself may worsen the PIH. PMID:23205540

  3. Assessment of metabolic bone disease: review of new nuclear medicine procedures

    SciTech Connect

    Wahner, H.W.

    1985-12-01

    In the management of patients with metabolic bone disease, nuclear medicine laboratories offer two nontraumatic procedures of potential clinical importance: bone mineral measurements and bone scintigraphy. Bone mineral measurements from the radius, lumbar spine, and hip obtained with use of absorptiometry or computed tomography can be used to predict the risk of fracture at these skeletal sites, can determine the severity of bone loss for the assessment of a benefit-versus-risk ratio on which appropriate therapy can be based, and can substantiate the effectiveness of therapy over time. Bone scintigraphy with use of labeled diphosphonate allows assessment of focal and, in defined circumstances, of total skeletal bone turnover in patients with normal kidney function. Both of these techniques have been used successfully in studies of population groups for the evaluation of trends. Their application to the management of individual patients is currently being evaluated. 41 references.

  4. Piezosurgery in Bone Augmentation Procedures Previous to Dental Implant Surgery: A Review of the Literature

    PubMed Central

    Magrin, Gabriel Leonardo; Sigua-Rodriguez, Eder Alberto; Goulart, Douglas Rangel; Asprino, Luciana

    2015-01-01

    The piezosurgery has been used with increasing frequency and applicability by health professionals, especially those who deal with dental implants. The concept of piezoelectricity has emerged in the nineteenth century, but it was applied in oral surgery from 1988 by Tomaso Vercellotti. It consists of an ultrasonic device able to cut mineralized bone tissue, without injuring the adjacent soft tissue. It also has several advantages when compared to conventional techniques with drills and saws, such as the production of a precise, clean and low bleed bone cut that shows positive biological results. In dental implants surgery, it has been used for maxillary sinus lifting, removal of bone blocks, distraction osteogenesis, lateralization of the inferior alveolar nerve, split crest of alveolar ridge and even for dental implants placement. The purpose of this paper is to discuss the use of piezosurgery in bone augmentation procedures used previously to dental implants placement. PMID:26966469

  5. Critical review of some multivariate procedures in the analysis of geochemical data

    USGS Publications Warehouse

    Miesch, A.T.

    1969-01-01

    Simulation experiments have been conducted to examine the potential usefulness of R-mode and Q-mode factor methods in the analysis and interpretation of geochemical data. The R-mode factor analysis experiment consisted of constructing a factor model, using the model to generate a correlation matrix, and attempting to recover the model by R-mode techniques. The techniques were successful in determining the number of factors in the model, but the factor loadings could not be estimated even approximately on the basis of mathematical procedures alone. Q-mode factor methods were successful in recovering all of the properties of a model used to generate hypothetical chemical data on olivine samples, but it was necessary to use a correction previously regarded as unimportant. ?? 1969 Plenum Publishing Corporation.

  6. Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology.

    PubMed

    Zhou, Jie; Du, Xuewen; Xu, Bing

    2015-01-01

    Formed by non-covalent interactions and not defined at genetic level, the assemblies of small molecules in biology are complicated and less explored. A common morphology of the supramolecular assemblies of small molecules is nanofibrils, which coincidentally resembles the nanofibrils formed by proteins such as prions. So these supramolecular assemblies are termed as prion-like nanofibrils of small molecules (PriSM). Emerging evidence from several unrelated fields over the past decade implies the significance of PriSM in biology and medicine. This perspective aims to highlight some recent advances of the research on PriSM. This paper starts with description of the intriguing similarities between PriSM and prions, discusses the paradoxical features of PriSM, introduces the methods for elucidating the biological functions of PriSM, illustrates several examples of beneficial aspects of PriSM, and finishes with the promises and current challenges in the research of PriSM. We anticipate that the research of PriSM will contribute to the fundamental understanding at the intersection of supramolecular chemistry and cell biology and ultimately lead to a new paradigm of molecular (or supramolecular) therapeutics for biomedicine.

  7. Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology

    PubMed Central

    Zhou, Jie; Du, Xuewen; Xu, Bing

    2015-01-01

    Abstract Formed by non-covalent interactions and not defined at genetic level, the assemblies of small molecules in biology are complicated and less explored. A common morphology of the supramolecular assemblies of small molecules is nanofibrils, which coincidentally resembles the nanofibrils formed by proteins such as prions. So these supramolecular assemblies are termed as prion-like nanofibrils of small molecules (PriSM). Emerging evidence from several unrelated fields over the past decade implies the significance of PriSM in biology and medicine. This perspective aims to highlight some recent advances of the research on PriSM. This paper starts with description of the intriguing similarities between PriSM and prions, discusses the paradoxical features of PriSM, introduces the methods for elucidating the biological functions of PriSM, illustrates several examples of beneficial aspects of PriSM, and finishes with the promises and current challenges in the research of PriSM. We anticipate that the research of PriSM will contribute to the fundamental understanding at the intersection of supramolecular chemistry and cell biology and ultimately lead to a new paradigm of molecular (or supramolecular) therapeutics for biomedicine. PMID:25738892

  8. The behavioral economics of drug self-administration: A review and new analytical approach for within-session procedures

    PubMed Central

    Bentzley, Brandon S.; Fender, Kimberly M.; Aston-Jones, Gary

    2012-01-01

    Rationale Behavioral-economic demand curve analysis offers several useful measures of drug self-administration. Although generation of demand curves previously required multiple days, recent within-session procedures allow curve construction from a single 110-min cocaine self-administration session, making behavioral-economic analyses available to a broad range of self-administration experiments. However, a mathematical approach of curve fitting has not been reported for the within-session threshold procedure. Objectives We review demand curve analysis in drug self-administration experiments and provide a quantitative method for fitting curves to single-session data that incorporates relative stability of brain drug concentration. Methods Sprague-Dawley rats were trained to self-administer cocaine, and then tested with the threshold procedure in which the cocaine dose was sequentially decreased on a fixed ratio-1 schedule. Price points (responses/mg cocaine) outside of relatively stable brain cocaine concentrations were removed before curves were fit. Curve-fit accuracy was determined by the degree of correlation between graphical and calculated parameters for cocaine consumption at low price (Q0) and the price at which maximal responding occurred (Pmax). Results Removing price points that occurred at relatively unstable brain cocaine concentrations generated precise estimates of Q0 and resulted in Pmax values with significantly closer agreement with graphical Pmax than conventional methods. Conclusion The exponential demand equation can be fit to single-session data using the threshold procedure for cocaine self-administration. Removing data points that occur during relatively unstable brain cocaine concentrations resulted in more accurate estimates of demand curve slope than graphical methods, permitting a more comprehensive analysis of drug self-administration via a behavioral-economic framework. PMID:23086021

  9. Reviewing Consensus HFE Standards for NRC Use: A Case Study using the IEEE Standard for Computerized Operating Procedure Systems

    SciTech Connect

    OHara, J.M.; Higgins, J.; Xing, J., Fleger S. - NRC

    2010-11-07

    The U.S. Nuclear Regulatory Commission’s (NRC’s) endorsement of consensus standards provides a cost-effective means of enhancing the staff’s ability to review state-of-the-art designs. Although the NRC endorsed consensus standards in many technical disciplines, it yet has to do so in human factors engineering (HFE). The purpose of our study was to develop a standardized methodology whereby to evaluate a consensus HFE standard to determine its appropriateness to, and adequacy for using in licensing reviews. The high-level objective of the methodology is to ensure that the guidance meets the NRC’s requirements on scientific- and engineering-rigor that they use in developing their own guidance. We propose four criteria for endorsing a consensus standard: (1) It should meet an existing need for NRC’s licensing and safety reviews; (2) it should be based on sound HFE principles; (3) it should be thoroughly peer-reviewed; and, (4) it should address human performance issues identified in the literature. Our methodology offers a means to assess these four criteria. We used it to evaluate an Institute of Electrical and Electronics Engineers’ (IEEE) draft standard on computerized operating procedure systems. We concluded that the IEEE standard generally met the established criteria, although several areas were identified that needed further clarification. Our evaluation methodology particularly was useful for identifying issues to be resolved, and for providing a basis for judging whether the staff should consider endorsing the standard. The methodology also helped recognize criteria in the proposed standard that may benefit from additional scrutiny by the staff. The evaluation methodology developed is applicable generally to reviewing other HFE standards that the NRC is considering for use or endorsement.

  10. Measurement of diffusion coefficients of VOCs for building materials: review and development of a calculation procedure.

    PubMed

    Haghighat, F; Lee, C S; Ghaly, W S

    2002-06-01

    The measurement and prediction of building material emission rates have been the subject of intensive research over the past decade, resulting in the development of advanced sensory and chemical analysis measurement techniques as well as the development of analytical and numerical models. One of the important input parameters for these models is the diffusion coefficient. Several experimental techniques have been applied to estimate the diffusion coefficient. An extensive literature review of the techniques used to measure this coefficient was carried out, for building materials exposed to volatile organic compounds (VOC). This paper reviews these techniques; it also analyses the results and discusses the possible causes of difference in the reported data. It was noted that the discrepancy between the different results was mainly because of the assumptions made in and the techniques used to analyze the data. For a given technique, the results show that there can be a difference of up to 700% in the reported data. Moreover, the paper proposes what is referred to as the mass exchanger method, to calculate diffusion coefficients considering both diffusion and convection. The results obtained by this mass exchanger method were compared with those obtained by the existing method considering only diffusion. It was demonstrated that, for porous materials, the convection resistance could not be ignored when compared with the diffusion resistance.

  11. Regional anesthesia for pediatric knee surgery: a review of the indications, procedures, outcomes, safety, and challenges

    PubMed Central

    Muhly, Wallis T; Gurnaney, Harshad G; Ganesh, Arjunan

    2015-01-01

    The indications for surgery on the knee in children and adolescents share some similarity to adult practice in that there are an increasing number of sports-related injuries requiring surgical repair. In addition, there are some unique age-related conditions or congenital abnormalities that may present as indications for orthopedic intervention at the level of the knee. The efficacy and safety of peripheral nerve blocks (PNBs) for postoperative analgesia following orthopedic surgery has been well established in adults. Recent studies have also demonstrated earlier functional recovery after surgery in patients who received PNBs. In children, PNB is gaining popularity, and increasing data are emerging to demonstrate the feasibility, efficacy, and safety in this population. In this paper, we will review some of the most common indications for surgery involving the knee in children and the anatomy of knee, associated dermatomal and osteotomal innervation, and the PNBs most commonly used to produce analgesia at the level of the knee. We will review the evidence in support of regional anesthesia in children in terms of both the quality conferred to the immediate postoperative care and the role of continuous PNBs in maintaining effective analgesia following discharge. Also we will discuss some of the subtle challenges in utilizing regional anesthesia in the pediatric patient including the use of general anesthesia when performing regional anesthesia and the issue of monitoring for compartment syndrome. Finally, we will offer some thoughts about areas of practice that are in need of further investigation. PMID:26609245

  12. Traumatic Extensor Tendon Injuries to the Hand: Clinical Anatomy, Biomechanics, and Surgical Procedure Review.

    PubMed

    Colzani, Giulia; Tos, Pierluigi; Battiston, Bruno; Merolla, Giovanni; Porcellini, Giuseppe; Artiaco, Stefano

    2016-04-01

    The extensor apparatus is a complex muscle-tendon system that requires integrity or optimal reconstruction to preserve hand function. Anatomical knowledge and the understanding of physiopathology of extensor tendons are essential for an accurate diagnosis of extensor tendon injuries (ETIs) of the hand and wrist, because these lesions are complex and commonly observed in clinical practice. A careful clinical history and assessment still remain the first step for the diagnosis, followed by US and MR to confirm the suspect of ETI or to investigate some doubtful conditions and rule out associate lesions. During last decades the evolution of surgical techniques and rehabilitative treatment protocol led to gradual improvement in clinical results of ETI treatment and surgical repair. Injury classification into anatomical zones and the evaluation of the characteristics of the lesions are considered key points to select the appropriate treatment for ETI. Both conservative and surgical management can be indicated in ETI, depending on the anatomical zone and on the characteristics of the injuries. As a general rule, an attempt of conservative treatment should be performed when the lesion is expected to have favorable result with nonoperative procedure. Many surgical techniques have been proposed over the time and with favorable results if the tendon injury is not underestimated and adequately treated. Despite recent research findings, a lack of evidence-based knowledge is still observed in surgical treatment and postoperative management of ETI. Further clinical and biomechanical investigations would be advisable to clarify this complex issue. PMID:27616821

  13. Procedural and methodological parameters in behavioral-gerontological research: a review.

    PubMed

    Mosher-Ashley, P M

    This article analyzes the behavioral-gerontological research published before 1984. The 151 studies located were classified into three main categories: observation, assessment, and intervention. Each study and each category were examined for variations in the behavioral procedures employed, and in the scientific research methods used to collect and analyze data. The survey indicated several serious problems in the research. Much of the behavioral-gerontological research focuses on institutionalized elderly, and tends to perpetuate a passive, helpless role on the part of the elderly in the treatment process. Less than 20 percent of the studies focused on observation or assessment, and most of these were found to be flawed. The intervention studies were also problematic; the majority of them were of short duration and had only one treatment phase which did not vary substantially during the study period. Most also failed to provide for interobserver agreement, generalization, maintenance, and follow-up assessments. Finally, the implications of these findings for future psychological research with the elderly are discussed.

  14. Malignancies in blood-forming organs following diagnostic and therapeutic procedures: a review.

    PubMed

    Hodgin, J D; Webster, P D

    1976-10-01

    Ionizing radiation used for diagnosis or therapy has been associated with an increased incidence of malignancies of blood-forming organs. The increased incidence of hematopoietic malignancies following exposure to ionizing radiation obtained in the course of occupation, diagnosis and therapy of disease, or as a weapon of war is documented. The natural occurrence and the induced progression to acute leukemia of polycythemia rubra vera, Hodgkin's disease, multiple myeloma, Di Guglielmo's disease, and reticuloendothelial malignancies are discussed. The status of transplantation and immunodeficiency states and their relationship to acute leukemia is reviewed. Finally, drugs, toxins, and the use of cytotoxic radiomimetic agents for nonmalignant purposes are shown to lead to the development of acute leukemia. Background information relevant to the proper use of future diagnostic and therapeutic modalities is provided.

  15. Paediatric acid-base disorders: A case-based review of procedures and pitfalls.

    PubMed

    Carmody, J Bryan; Norwood, Victoria F

    2013-01-01

    Acid-base disorders occur frequently in paediatric patients. Despite the perception that their analysis is complex and difficult, a straightforward set of rules is sufficient to interpret even the most complex disorders - provided certain pitfalls are avoided. Using a case-based approach, the present article reviews the fundamental concepts of acid-base analysis and highlights common mistakes and oversights. Specific topics include the proper identification of the primary disorder; distinguishing compensatory changes from additional primary disorders; use of the albumin-corrected anion gap to generate a differential diagnosis for patients with metabolic acidosis; screening for mixed disorders with the delta-delta formula; recognizing the limits of compensation; use of the anion gap to identify 'hidden' acidosis; and the importance of using information from the history and physical examination to identify the specific cause of a patient's acid-base disturbance.

  16. The crystal structure of Neisseria gonorrhoeae PriB reveals mechanistic differences among bacterial DNA replication restart pathways

    SciTech Connect

    Dong, Jinlan; George, Nicholas P.; Duckett, Katrina L.; DeBeer, Madeleine A.P.; Lopper, Matthew E.

    2010-05-25

    Reactivation of repaired DNA replication forks is essential for complete duplication of bacterial genomes. However, not all bacteria encode homologs of the well-studied Escherichia coli DNA replication restart primosome proteins, suggesting that there might be distinct mechanistic differences among DNA replication restart pathways in diverse bacteria. Since reactivation of repaired DNA replication forks requires coordinated DNA and protein binding by DNA replication restart primosome proteins, we determined the crystal structure of Neisseria gonorrhoeae PriB at 2.7 {angstrom} resolution and investigated its ability to physically interact with DNA and PriA helicase. Comparison of the crystal structures of PriB from N. gonorrhoeae and E. coli reveals a well-conserved homodimeric structure consisting of two oligosaccharide/oligonucleotide-binding (OB) folds. In spite of their overall structural similarity, there is significant species variation in the type and distribution of surface amino acid residues. This correlates with striking differences in the affinity with which each PriB homolog binds single-stranded DNA and PriA helicase. These results provide evidence that mechanisms of DNA replication restart are not identical across diverse species and that these pathways have likely become specialized to meet the needs of individual organisms.

  17. Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.

    PubMed

    Sasaki, Kaori; Ose, Toyoyuki; Okamoto, Naoaki; Maenaka, Katsumi; Tanaka, Taku; Masai, Hisao; Saito, Mihoko; Shirai, Tsuyoshi; Kohda, Daisuke

    2007-05-16

    In eubacteria, PriA helicase detects the stalled DNA replication forks. This critical role of PriA is ascribed to its ability to bind to the 3' end of a nascent leading DNA strand in the stalled replication forks. The crystal structures in complexes with oligonucleotides and the combination of fluorescence correlation spectroscopy and mutagenesis reveal that the N-terminal domain of PriA possesses a binding pocket for the 3'-terminal nucleotide residue of DNA. The interaction with the deoxyribose 3'-OH is essential for the 3'-terminal recognition. In contrast, the direct interaction with 3'-end nucleobase is unexpected, considering the same affinity for oligonucleotides carrying the four bases at the 3' end. Thus, the N-terminal domain of PriA recognizes the 3'-end base in a base-non-selective manner, in addition to the deoxyribose and 5'-side phosphodiester group, of the 3'-terminal nucleotide to acquire both sufficient affinity and non-selectivity to find all of the stalled replication forks generated during DNA duplication. This unique feature is prerequisite for the proper positioning of the helicase domain of PriA on the unreplicated double-stranded DNA. PMID:17464287

  18. Blocking the maturation of OncomiRNAs using pri-miRNA-17∼92 aptamer in retinoblastoma.

    PubMed

    Subramanian, Nithya; Kanwar, Jagat R; Kanwar, Rupinder K; Krishnakumar, Subramanian

    2015-02-01

    The miR-17∼92. or oncomiR-1, cluster encodes oncogenic microRNAs (miRNAs), and it also promotes retinoblastoma (RB) tumor formation. Antagomir and miRNA mimics based approaches are widely tried against oncogenic and tumor suppressive miRNAs. Other methods for targeting cancer related miRNAs are still under development. In the current study, we focused on the pri-miRNA-17∼92 aptamer (pri-apt), which can potentially replace the mix of five antagomirs by one aptamer that function to abrogate the maturation of miR-17, miR-18a, and miR-19b (P<0.05) for targeting RB. We used RB cell lines WERI-Rb1 and Y79 as an in vitro model. Cellular changes upon transfecting the pri-apt led to S-phase arrest in WERI-Rb1 cells and onset of apoptosis in both Y79 and WERI-Rb1 cell lines. There was increased cytotoxicity as measured by lactate dehydrogenase activity in pri-apt treated Y79 cells (P<0.05), and significant inhibition of cell proliferation was observed in both of the cell lines. Thus we showed the antiproliferative property of pri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells. PMID:25513843

  19. Blocking the Maturation of OncomiRNAs Using pri-miRNA-17∼92 Aptamer in Retinoblastoma

    PubMed Central

    Subramanian, Nithya; Kanwar, Jagat R.; Kanwar, Rupinder K.

    2015-01-01

    The miR-17∼92. or oncomiR-1, cluster encodes oncogenic microRNAs (miRNAs), and it also promotes retinoblastoma (RB) tumor formation. Antagomir and miRNA mimics based approaches are widely tried against oncogenic and tumor suppressive miRNAs. Other methods for targeting cancer related miRNAs are still under development. In the current study, we focused on the pri-miRNA-17∼92 aptamer (pri-apt), which can potentially replace the mix of five antagomirs by one aptamer that function to abrogate the maturation of miR-17, miR-18a, and miR-19b (P<0.05) for targeting RB. We used RB cell lines WERI-Rb1 and Y79 as an in vitro model. Cellular changes upon transfecting the pri-apt led to S-phase arrest in WERI-Rb1 cells and onset of apoptosis in both Y79 and WERI-Rb1 cell lines. There was increased cytotoxicity as measured by lactate dehydrogenase activity in pri-apt treated Y79 cells (P<0.05), and significant inhibition of cell proliferation was observed in both of the cell lines. Thus we showed the antiproliferative property of pri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells. PMID:25513843

  20. A systematic review of minimally invasive surgical treatment for atrial fibrillation: a comparison of the Cox-Maze procedure, beating-heart epicardial ablation, and the hybrid procedure on safety and efficacy.

    PubMed

    Je, Hyung Gon; Shuman, Deborah J; Ad, Niv

    2015-10-01

    There is a growing trend to perform off-bypass surgical ablation for atrial fibrillation (AF) because it is perceived to be safer and more effective than the Cox-Maze procedure with cardiopulmonary bypass (CPB) support. In this systematic review, we compared three minimally invasive stand-alone surgical ablation procedures for AF: the endocardial Cox-Maze procedure, epicardial surgical ablation and a hybrid epicardial surgical and catheter-based endocardial ablation procedure (hybrid procedure). Relevant studies were identified in MEDLINE and the Cochrane Database of Systematic Reviews according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. From 565 initial studies, 37 were included in this review. The total number of patients across all studies was 1877 (range 10-139). Two studies reported on endocardial Cox-Maze procedures (n = 145), 26 reported on epicardial surgical ablation (n = 1382) and 9 reported on hybrid surgical ablation (n = 350). For minimally invasive Cox-Maze, epicardial and hybrid groups, operative mortality rates were 0, 0.5 and 0.9%, perioperative permanent pacemaker insertion rates were 3.5, 2.7 and 1.5%, incidence of conversion to median sternotomy was 0, 2.4 and 2.5%, and reoperation for bleeding was 1.0, 1.5 and 2.2%, with mean length of stay (days) of 5.4, 6.0 and 4.6, respectively. At 12 months, rates of sinus rhythm restoration were 93, 80 and 70%, and sinus restoration without anti-arrhythmic medications was 87, 72 and 71%, for Cox-Maze, epicardial and hybrid procedures, respectively. Of the three procedures, the minimally invasive Cox-Maze procedure with CPB support was most effective for the treatment of stand-alone AF and had important safety advantages in conversion to sternotomy and major bleeding. The minimally invasive Cox-Maze procedure with CPB support also demonstrated the potential for a higher success rate 12 months following the procedure.

  1. A review of combined experimental and computational procedures for assessing biopolymer structure–process–property relationships

    PubMed Central

    Gronau, Greta; Krishnaji, Sreevidhya T.; Kinahan, Michelle E.; Giesa, Tristan; Wong, Joyce Y.; Kaplan, David L.; Buehler, Markus J.

    2013-01-01

    Tailored biomaterials with tunable functional properties are desirable for many applications ranging from drug delivery to regenerative medicine. To improve the predictability of biopolymer materials functionality, multiple design parameters need to be considered, along with appropriate models. In this article we review the state of the art of synthesis and processing related to the design of biopolymers, with an emphasis on the integration of bottom-up computational modeling in the design process. We consider three prominent examples of well-studied biopolymer materials – elastin, silk, and collagen – and assess their hierarchical structure, intriguing functional properties and categorize existing approaches to study these materials. We find that an integrated design approach in which both experiments and computational modeling are used has rarely been applied for these materials due to difficulties in relating insights gained on different length- and time-scales. In this context, multiscale engineering offers a powerful means to accelerate the biomaterials design process for the development of tailored materials that suit the needs posed by the various applications. The combined use of experimental and computational tools has a very broad applicability not only in the field of biopolymers, but can be exploited to tailor the properties of other polymers and composite materials in general. PMID:22938765

  2. A Biological and Procedural Review of Forensically Significant Dermestes Species (Coleoptera: Dermestidae).

    PubMed

    Magni, Paola A; Voss, Sasha C; Testi, Roberto; Borrini, Matteo; Dadour, Ian R

    2015-09-01

    The analyses of the insect species found on decomposing remains may provide useful information for the estimation of the minimum time elapsed since death and other parameters, such as causes and circumstances of death. The majority of research has focused on the early colonizing species, typically blowflies, while research concerning late colonizing insects is currently sparse. Dermestid beetles of the genus Dermestes L. (Coleoptera: Dermestidae) are one of the predominant insect species associated with decomposing remains during dry decay and skeletal stages of decomposition. In some dry environments, Dermestes species are likely to be the only necrophagous insects feeding on the decomposing remains. Furthermore, Dermestes species (immature and adults), their remains (cast skins and fecal material), and their artifacts (pupal chambers) are frequently found associated with ancient remains (e.g., mummies, fossils). Dermestes species have a worldwide distribution and are considered important in decomposition processes, forensic investigations, and economically as a known pest of stored products. Despite their recognized forensic importance, there is limited data documenting the ecology, biology, and the growth rates of the forensically relevant species. The aim of this review is to provide a comprehensive synopsis on the available literature concerning Dermestes species associated with forensic cases. In particular, aspects of colonization behavior, growth rates for forensic taxa and potential best practice guidelines for forensic casework encompassing late colonizing Dermestes species are discussed. PMID:26336246

  3. Procedures to view aberrations--a travel from protein to gene: literature review.

    PubMed

    Premalatha, B; Ramesh, V; Babu, S P K Kennedy; Balamurali, P D

    2014-01-01

    The diagnosis of any pathology is fundamentally based on the microscopic structure of cells and tissues and this remains as the standard by which all other diagnostic tests are measured. In this era, the pathologists are relying on the examination of tissue section stained by histochemical means and it is supported by the advanced immunological, biochemical and molecular techniques. This review will provide the information about one of the way that can be followed to unravel the molecular mechanism in spotting the disease process. Technologies used to study the cellular process are same for the normal and the abnormal cell. Experimental strategy briefed here is also applicable for both. The cellular process can be studied either from protein to gene or from gene to protein. Earlier days biochemical analysis (isolation of protein, protein sequencing) was separate and genetic analysis (genomic mapping) was separate. But now with advent of recombinant DNA technology it is possible to have a link between the biochemical and genetic analysis. Intermediary step of development of oligonucleotide synthesis, complementary DNA probe and cloning has revolutionized the research process. Identified gene can be compared with the normal gene by comparative genomics or expressed proteins by expression proteomics. PMID:24748307

  4. A Biological and Procedural Review of Forensically Significant Dermestes Species (Coleoptera: Dermestidae).

    PubMed

    Magni, Paola A; Voss, Sasha C; Testi, Roberto; Borrini, Matteo; Dadour, Ian R

    2015-09-01

    The analyses of the insect species found on decomposing remains may provide useful information for the estimation of the minimum time elapsed since death and other parameters, such as causes and circumstances of death. The majority of research has focused on the early colonizing species, typically blowflies, while research concerning late colonizing insects is currently sparse. Dermestid beetles of the genus Dermestes L. (Coleoptera: Dermestidae) are one of the predominant insect species associated with decomposing remains during dry decay and skeletal stages of decomposition. In some dry environments, Dermestes species are likely to be the only necrophagous insects feeding on the decomposing remains. Furthermore, Dermestes species (immature and adults), their remains (cast skins and fecal material), and their artifacts (pupal chambers) are frequently found associated with ancient remains (e.g., mummies, fossils). Dermestes species have a worldwide distribution and are considered important in decomposition processes, forensic investigations, and economically as a known pest of stored products. Despite their recognized forensic importance, there is limited data documenting the ecology, biology, and the growth rates of the forensically relevant species. The aim of this review is to provide a comprehensive synopsis on the available literature concerning Dermestes species associated with forensic cases. In particular, aspects of colonization behavior, growth rates for forensic taxa and potential best practice guidelines for forensic casework encompassing late colonizing Dermestes species are discussed.

  5. The efficacy of eutectic mixture of local anesthetics as a topical anesthetic agent used for dental procedures: A brief review

    PubMed Central

    Daneshkazemi, Alireza; Abrisham, Seyyed Mohammad; Daneshkazemi, Pedram; Davoudi, Amin

    2016-01-01

    Dental pain management is one of the most critical aspects of modern dentistry which might affect patient's quality of life. Several methods are suggested to provide a painless situation for patients. Desensitization of the oral site using topical anesthetics is one of those methods. The improvements of topical anesthetic agents are probably one of the most important advances in dental science in the past 100 years. Most of them are safe and can be applied on oral mucosa with minimal irritation and allergic reactions. At present, these agents are various with different potent and indications. Eutectic mixture of local anesthetics (EMLA) (lidocaine + prilocaine) is a commercial anesthetic agent which has got acceptance among dental clinicians. This article provides a brief review about the efficacy of EMLA as a topical anesthetic agent when used during dental procedures. PMID:27746520

  6. Road-corridor planning in the EIA procedure in Spain. A review of case studies

    SciTech Connect

    Loro, Manuel [Department of Urban and Regional Planning and Environment, Civil Engineering School, Universidad Politécnica de Madrid, Prof. Aranguren s Transport Research Centre Universidad Politécnica de Madrid, ETSI Caminos, Canales y Puertos, Prof. Aranguren s Centro de investigación del transporte, TRANSyT-UPM, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, Prof. Aranguren s Arce, Rosa M. [Department of Urban and Regional Planning and Environment, Civil Engineering School, Universidad Politécnica de Madrid, Prof. Aranguren s Transport Research Centre Universidad Politécnica de Madrid, ETSI Caminos, Canales y Puertos, Prof. Aranguren s Centro de investigación del transporte, TRANSyT-UPM, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, Prof. Aranguren s Ortega, Emilio [Transport Research Centre Universidad Politécnica de Madrid, ETSI Caminos, Canales y Puertos, Prof. Aranguren s Centro de investigación del transporte, TRANSyT-UPM, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, Prof. Aranguren s Department of Construction and Rural Roads, Forestry Engineering School, Universidad Politécnica de Madrid, Ciudad Universitaria s and others

    2014-01-15

    The assessment of different alternatives in road-corridor planning must be based on a number of well-defined territorial variables that serve as decision making criteria, and this requires a high-quality preliminary environmental assessment study. In Spain the formal specifications for the technical requirements stipulate the constraints that must be considered in the early stages of defining road corridors, but not how they should be analyzed and ranked. As part of the feasibility study of a new road definition, the most common methodology is to establish different levels of Territorial Carrying Capacity (TCC) in the study area in order to summarize the territorial variables on thematic maps and to ease the tracing process of road-corridor layout alternatives. This paper explores the variables used in 22 road-construction projects conducted by the Ministry of Public Works that were subject to the Spanish EIA regulation and published between 2006 and 2008. The aim was to evaluate the quality of the methods applied and the homogeneity and suitability of the variables used for defining the TCC. The variables were clustered into physical, environmental, land-use and cultural constraints for the purpose of comparing the TCC values assigned in the studies reviewed. We found the average quality of the studies to be generally acceptable in terms of the justification of the methodology, the weighting and classification of the variables, and the creation of a synthesis map. Nevertheless, the methods for assessing the TCC are not sufficiently standardized; there is a lack of uniformity in the cartographic information sources and methodologies for the TCC valuation. -- Highlights: • We explore 22 road-corridor planning studies subjected to the Spanish EIA regulation. • We analyze the variables selected for defining territorial carrying capacity. • The quality of the studies is acceptable (methodology, variable weighting, mapping). • There is heterogeneity in the

  7. SDZ PRI 053, an orally bioavailable human immunodeficiency virus type 1 proteinase inhibitor containing the 2-aminobenzylstatine moiety.

    PubMed Central

    Billich, A; Fricker, G; Müller, I; Donatsch, P; Ettmayer, P; Gstach, H; Lehr, P; Peichl, P; Scholz, D; Rosenwirth, B

    1995-01-01

    A series of inhibitors of human immunodeficiency virus type 1 (HIV-1) proteinase containing the 2-aralkyl-amino-substituted statine moiety as a novel transition-state analog was synthesized, with the aim to obtain compounds which combine anti-HIV potency with oral bioavailability. The reduced-size 2-aminobenzylstatine derivative SDZ PRI 053, which contains 2-(S)-amino-3-(R)-hydroxyindane in place of an amino acid amide, is a potent and orally bioavailable inhibitor of HIV-1 replication. The antiviral activity of SDZ PRI 053 was demonstrated in various cell lines, in primary lymphocytes, and in primary monocytes, against laboratory strains as well as clinical HIV-1 isolates (50% effective dose = 0.028 to 0.15 microM). Cell proliferation was impaired only at 100- to 300-fold-higher concentrations. The mechanism of antiviral action of the proteinase inhibitor SDZ PRI 0.53 was demonstrated to be inhibition of gag precursor protein processing. The finding that the inhibitory potency of SDZ PRI 053 in chronic virus infection, determined by p24 release, was considerably lower than that in de novo infection may be explained by the fact that the virus particles produced in the presence of SDZ PRI 053 are about 50-fold less infectious than those from untreated cultures. Upon intravenous administration, half-lives in blood of 100 and 32 min in mice and rats, respectively, were measured. Oral bioavailability of SDZ PRI 053 in rodents was 20 to 60%, depending on the dose. In mice, rats, and dogs, the inhibitor levels after oral administration remained far above the concentrations needed to efficiently block HIV replication in vitro for a prolonged period. This compound is thus a promising candidate for clinical use in HIV disease. PMID:7492076

  8. Assessment of uterine cavity size and shape: a systematic review addressing relevance to intrauterine procedures and events.

    PubMed

    Goldstuck, Norman

    2012-09-01

    Uterine cavity measurement began with evaluation of post-mortem and surgical specimens. It has been extended in vivo by use of mechanical instruments and visualization techniques. This is a systematic review of the range of values for the uterine cavity and the practical implications of these measurements, Following a review of multiple data bases & a QUORUM analysis. Only articles with clearly defined quantitative measurements were included. Mechanical cavity measurements with a variety of instruments gave a mean endometrial cavity length (ECL) of 33.73 mm (18-22.1) and a mean endometrial cavity width (ECW) of 25.1 mm (17.8-32.2) for nulliparae. The values for multiparae were mean ECL 38.6mm(20.61-40.3) and mean ECW 34.9 mm (23.4-53). Imaging measurements for the uterine cavity by hysterography and ultrasound were mean ECL 44.3 mm (29-64) for multiparae and ECL 37 mm for nulliparae. Mean ECW was 28.2 mm (21-33) for nulliparae and 32.1 mm (26-38) for multiparae. There were wide variations due to parity, ethnicity and gestational states. Accurate measurement of intrauterine parameters is valuable for improving and enhancing many intrauterine procedures including IUD insertion, endometrial ablation, embryo placement in IVF and management of spontaneous and therapeutic abortion. PMID:23437507

  9. Assessing canopy PRI from airborne imagery to map water stress in maize

    NASA Astrophysics Data System (ADS)

    Rossini, M.; Fava, F.; Cogliati, S.; Meroni, M.; Marchesi, A.; Panigada, C.; Giardino, C.; Busetto, L.; Migliavacca, M.; Amaducci, S.; Colombo, R.

    2013-12-01

    This paper presents a method for mapping water stress in a maize field using hyperspectral remote sensing imagery. An airborne survey using AISA (Specim, Finland) was performed in July 2008 over an experimental farm in Italy. Hyperspectral data were acquired over a maize field with three different irrigation regimes. An intensive field campaign was also conducted concurrently with imagery acquisition to measure relative leaf water content (RWC), active chlorophyll fluorescence (ΔF/Fm‧), leaf temperature (Tl) and Leaf Area Index (LAI). The analysis of the field data showed that at the time of the airborne overpass the maize plots with irrigation deficits were experiencing a moderate water stress, affecting the plant physiological status (ΔF/Fm‧, difference between Tl and air temperature (Tair), and RWC) but not the canopy structure (LAI). Among the different Vegetation Indices (VIs) computed from the airborne imagery the Photochemical Reflectance Index computed using the reflectance at 570 nm as the reference band (PRI570) showed the strongest relationships with ΔF/Fm‧ (r2 = 0.76), Tl - Tair (r2 = 0.82) and RWC (r2 = 0.64) and the red-edge Chlorophyll Index (CIred-edge) with LAI (r2 = 0.64). Thus PRI has been proven to be related to water stress at early stages, before structural changes occurred.

  10. A review of downscaling procedures - a contribution to the research on climate change impacts at city scale

    NASA Astrophysics Data System (ADS)

    Smid, Marek; Costa, Ana; Pebesma, Edzer; Granell, Carlos; Bhattacharya, Devanjan

    2016-04-01

    Human kind is currently predominantly urban based, and the majority of ever continuing population growth will take place in urban agglomerations. Urban systems are not only major drivers of climate change, but also the impact hot spots. Furthermore, climate change impacts are commonly managed at city scale. Therefore, assessing climate change impacts on urban systems is a very relevant subject of research. Climate and its impacts on all levels (local, meso and global scale) and also the inter-scale dependencies of those processes should be a subject to detail analysis. While global and regional projections of future climate are currently available, local-scale information is lacking. Hence, statistical downscaling methodologies represent a potentially efficient way to help to close this gap. In general, the methodological reviews of downscaling procedures cover the various methods according to their application (e.g. downscaling for the hydrological modelling). Some of the most recent and comprehensive studies, such as the ESSEM COST Action ES1102 (VALUE), use the concept of Perfect Prog and MOS. Other examples of classification schemes of downscaling techniques consider three main categories: linear methods, weather classifications and weather generators. Downscaling and climate modelling represent a multidisciplinary field, where researchers from various backgrounds intersect their efforts, resulting in specific terminology, which may be somewhat confusing. For instance, the Polynomial Regression (also called the Surface Trend Analysis) is a statistical technique. In the context of the spatial interpolation procedures, it is commonly classified as a deterministic technique, and kriging approaches are classified as stochastic. Furthermore, the terms "statistical" and "stochastic" (frequently used as names of sub-classes in downscaling methodological reviews) are not always considered as synonymous, even though both terms could be seen as identical since they are

  11. Explaining the variability of the photochemical reflectance index (PRI) at the canopy-scale: Disentangling the effects of phenological and physiological changes.

    PubMed

    Merlier, Elodie; Hmimina, Gabriel; Dufrêne, Eric; Soudani, Kamel

    2015-10-01

    Assessing photosynthesis rates at the ecosystem scale and over large regions is important for tracking the global carbon cycle and remote sensing has provided new and useful approaches for performing this assessment. The photochemical reflectance index (PRI) is a good estimator of short-term light-use efficiency (LUE) at the leaf scale; however, confounding factors appear at larger temporal and spatial scales. In this study, canopy-scale PRI variability was investigated for three species (Fagus sylvatica L., Quercus robur L. and Pinus sylvestris L.) growing under contrasting soil moisture conditions. Throughout the growing season, no significant differences in chlorophyll content and in violaxanthin, antheraxanthin and zeaxanthin were found between species or treatments. The daily PRI vs PAR (photosynthetically active radiation) relationships were determined using continuous measurements obtained at high frequency throughout the entire growing season, from early spring budburst to later autumn senescence, and were used to deconvolute the physiological PRI variability related to LUE variations due to phenological variability and related to temporal changes in the biochemical and structural canopy attributes. The PRI vs PAR relationship is used to show that the canopy-scale PRI measured at low radiation depends on the chlorophyll content of the canopy. The range of PRI variations at an intra-daily scale and the dynamics of the xanthophyll pool do not vary between days, which suggests that the PRI responds to a xanthophyll ratio. The PAR values at PRI saturation are mainly related to the canopy chlorophyll content during budburst and senescence and to the soil moisture content when the chlorophyll content is no longer a limiting factor. This parameter is significantly lower in the oak species that experience less stress from variations in soil moisture and is species dependant. These results provide new insights regarding the analysis and the meaning of PRI

  12. Successful Management of Two Cases of Placenta Accreta and a Literature Review: Use of the B-Lynch Suture and Bilateral Uterine Artery Ligation Procedures

    PubMed Central

    Arab, Maliheh; Ghavami, Behnaz; Saraeian, Samaneh; Sheibani, Samaneh; Abbasian Azar, Fatemeh; Hosseini-Zijoud, Seyed-Mostafa

    2016-01-01

    Introduction Placenta accreta is an increasingly common complication of pregnancy that can result in massive hemorrhage. Case Presentation We describe two cases of placenta accreta, with successful conservative management in a referral hospital in Tehran, Iran. In both cases, two procedures were performed: compression suture (B-Lynch) and a perfusion-decreasing procedure (bilateral uterine artery ligation). We also present the results of a narrative literature review. Conclusions The double B-Lynch and uterine arterial ligation procedure in cases of abnormal placentation might be strongly considered in fertility preservation, coagulopathy, coexisting medical disease, blood access shortage, low surgical experience, distant local hospitals, and no help. PMID:27354921

  13. Use of Tumescence for Outpatient Abdominoplasty and Other Concurrent Body Contouring Procedures: A Review of 65 Consecutive Patients

    PubMed Central

    Holzman, Nathaniel L.; Singh, Mansher; Caterson, Stephanie A.; Eriksson, Elof

    2015-01-01

    Introduction: Abdominoplasty is being increasingly performed as an outpatient procedure. The role of tumescent technique in decreasing postoperative pain and hospital stay has not been extensively studied. Methods: We reviewed 65 consecutive patients who underwent tumescent abdominoplasty over 20 months by a single surgeon. All the patients were followed up for at least 1 year. The outcomes were evaluated in terms of systemic complications such as deep vein thrombosis and pulmonary embolism and local complications such as seroma, wound infection, and skin necrosis. Results: Of the 65 patient records analyzed, 61 were of females and 4 of males. Average age for the patient population was 45.2 years. Mean follow-up was at least 1 year for all the patients. Ninety-five percent of patients could be discharged the same day with tumescent abdominoplasty, whereas 71% of the patients who underwent concurrent procedures with abdominoplasty were also able to go home the same day. All the patients reported excellent postoperative pain control. There was no report of deep vein thrombosis or pulmonary embolism in any of these patients. Wound complications occurred in 14 patients (21.6%), of which 12 patients had seroma (18.5%) and 2 had wound infection (3.1%). The seromas were treated with repeated aspirations or Jackson-Pratt drain placement, whereas the wound infections resolved with outpatient antibiotics. Conclusions: The safety and efficiency of outpatient abdominoplasty can be further facilitated by utilizing tumescence. Tumescence helps the patients be discharged sooner, usually the same day, mobilize sooner, and rely less on oral narcotics at home. PMID:26366244

  14. Numerical simulation for horizontal subsurface flow constructed wetlands: A short review including geothermal effects and solution bounding in biodegradation procedures

    NASA Astrophysics Data System (ADS)

    Liolios, K.; Tsihrintzis, V.; Angelidis, P.; Georgiev, K.; Georgiev, I.

    2016-10-01

    Current developments on modeling of groundwater flow and contaminant transport and removal in the porous media of Horizontal Subsurface Flow Constructed Wetlands (HSF CWs) are first reviewed in a short way. The two usual environmental engineering approaches, the black-box and the process-based one, are briefly presented. Next, recent research results obtained by using these two approaches are briefly discussed as application examples, where emphasis is given to the evaluation of the optimal design and operation parameters concerning HSF CWs. For the black-box approach, the use of Artificial Neural Networks is discussed for the formulation of models, which predict the removal performance of HSF CWs. A novel mathematical prove is presented, which concerns the dependence of the first-order removal coefficient on the Temperature and the Hydraulic Residence Time. For the process-based approach, an application example is first discussed which concerns procedures to evaluate the optimal range of values for the removal coefficient, dependent on either the Temperature or the Hydraulic Residence Time. This evaluation is based on simulating available experimental results of pilot-scale units operated in Democritus University of Thrace, Xanthi, Greece. Further, in a second example, a novel enlargement of the system of Partial Differential Equations is presented, in order to include geothermal effects. Finally, in a third example, the case of parameters uncertainty concerning biodegradation procedures is considered and the use of upper and a novel approach is presented, which concerns the upper and the lower solution bound for the practical draft design of HSF CWs.

  15. Remote sensing of plant emissions of volatile isoprenoids with PRI. Prospects for upscaling (Invited)

    NASA Astrophysics Data System (ADS)

    Penuelas, J.

    2013-12-01

    Josep Peñuelas*1,2, Giovanni Marino1,2,3,4, Joan LLusia1,2, Catherine Morfopoulos1,2,5, Gerard Farre-Armengol1,2, Shawn Kefauver, Alex Guenther6 , Francesca Rapparini7 , Roger Seco1,2,6, Marc Estiarte1,2, Mónica Mejia-Chang1,2, Romà Ogaya1,2, Jordi Sardans1,2 , Andrew Turnipseed6, Peter Harley6, Osvaldo Facini7, Rita Baraldi7, Jim Greenberg6 , Iolanda Filella1,2 1 CSIC, Global Ecology Unit CREAF-CEAB-UAB, Cerdanyola del Vallés 08193, Catalonia, Spain 2 CREAF, Cerdanyola del Vallés 08193, Catalonia, Spain 3 Dipartimento di Bioscienze e Territorio, Università degli Studi del Molise, Contrada Fonte Lappone, 86090 Pesche (IS), Italy 4 Institute for Plant Protection, National Research Council, Via Madonna del Piano 10, 50019 Sesto Fiorentino (FI), Italy 5 Division of Ecology and Evolution, Imperial College, Silwood Park, Ascot, SL5 7PY, UK 6 Atmospheric Chemistry Division, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000, USA 7 Biometeorology Institute, IBIMET-CNR, Via P. Gobetti 101, Bologna, Italy Abstract Terrestrial plants re-emit around 1-2% of the carbon they fix as isoprene and monoterpenes. These emissions play major roles in the ecological relationships among living organisms and in atmospheric chemistry and climate, and yet their actual quantification at the ecosystem level in different regions is far from being resolved. Phenomenological models are used to estimate the emission rates, but the limited understanding of the function and regulation of these emissions leads to large uncertainties in such estimations. Many measurements have been made at the foliar but few at the ecosystem level, and those that do exist are limited in space and time. We here provide evidence that a simple remote sensing index, the photochemical reflectance index (PRI), which is indicative of light use efficiency (LUE), is a good indirect estimator of foliar isoprenoid emissions and therefore can be used to sense them remotely. These results open

  16. PriA mediates DNA replication pathway choice at recombination intermediates.

    PubMed

    Xu, Liewei; Marians, Kenneth J

    2003-03-01

    We report the reconstitution of the initial steps of the double-strand break-repair pathway where joint molecule formation between a duplex DNA fragment and a circular template by the combined action of RecA, RecBCD, and the single-stranded DNA binding protein provides the substrate for replication fork formation by the restart primosome and the DNA polymerase III holoenzyme. We show that PriA dictates the pathway of replication from the recombination intermediate by inhibiting a nonspecific, strand displacement DNA synthesis reaction and favoring the formation of a bona fide replication fork. Furthermore, we find that RecO and RecR significantly stimulate this recombination-directed DNA replication reaction, and that this stimulation is modulated by the presence of RecF, suggesting that the latter protein may also act as a regulator of the pathway of resolution of the recombination intermediate. PMID:12667462

  17. Increasing the Rigor of Procedural Fidelity Assessment: An Empirical Comparison of Direct Observation and Permanent Product Review Methods

    ERIC Educational Resources Information Center

    Sanetti, Lisa M. Hagermoser; Collier-Meek, Melissa A.

    2014-01-01

    Although it is widely accepted that procedural fidelity data are important for making valid decisions about intervention effectiveness, there is little empirical guidance for researchers and practitioners regarding how to assess procedural fidelity. A first step in moving procedural fidelity assessment research forward is to develop a…

  18. iStent as a Solo Procedure for Glaucoma Patients: A Systematic Review and Meta-Analysis

    PubMed Central

    Malvankar-Mehta, Monali S.; Chen, Yufeng Nancy; Iordanous, Yiannis; Wang, Wan Wendy; Costella, John; Hutnik, Cindy M. L.

    2015-01-01

    Background Glaucoma is a leading cause of irreversible blindness. It is firmly entrenched in the traditional treatment paradigm to start with pharmacotherapy. However, pharmacotherapy is not benign and has been well documented to have a number of significant challenges. Minimally invasive glaucoma surgery (MIGS) that targets the outflow pathway with minimal to no scleral dissection has resulted in the need to reconsider the glaucoma treatment paradigm. Purpose To perform a systematic review and meta-analysis to evaluate and quantify the effect on post-operative intraocular pressure (IOP) and number of topical glaucoma medications, in patients receiving the iStent MIGS device as the solo procedure without concurrent cataract surgery. Methods A systematic review was conducted by searching various databases between January 1, 2000, and June 30, 2014. Studies reporting up to a maximum follow-up period of 24 months were retrieved and screened using the EPPI-Reviewer 4 gateway. Percentage reduction in IOP (IOPR%), and mean reduction in topical glaucoma medications after surgery were computed. Meta-analysis was performed using STATA v. 13.0. The standardized mean difference (SMD) was calculated as the effect size for continuous scale outcomes. Heterogeneity was determined using the I2 statistics, Z-value, and χ2 statistics. Fixed-effect and random-effect models were developed based on heterogeneity. Sub-group analysis was performed based on the number of iStents implanted and the follow-up period. The outcome measures were changes in the IOP and number of glaucoma medications. Results The search strategy identified 105 records from published literature and 9 records from the grey literature. Five studies with 248 subjects were included for quantitative synthesis. A 22% IOP reduction (IOPR%) from baseline occurred at 18-months after one iStent implant, 30% at 6-months after two iStents implantations, and 40% at 6-months after implantation of three iStents. A mean

  19. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  20. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  1. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  2. 26 CFR 301.6103(p)(7)-1 - Procedures for administrative review of a determination that an authorized recipient has failed...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... determination that an authorized recipient has failed to safeguard returns or return information. 301.6103(p)(7)-1 Section 301.6103(p)(7)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6103(p)(7)-1 Procedures for administrative review of a determination that an...

  3. Dental Procedures.

    PubMed

    Ramponi, Denise R

    2016-01-01

    Dental problems are a common complaint in emergency departments in the United States. There are a wide variety of dental issues addressed in emergency department visits such as dental caries, loose teeth, dental trauma, gingival infections, and dry socket syndrome. Review of the most common dental blocks and dental procedures will allow the practitioner the opportunity to make the patient more comfortable and reduce the amount of analgesia the patient will need upon discharge. Familiarity with the dental equipment, tooth, and mouth anatomy will help prepare the practitioner for to perform these dental procedures. PMID:27482994

  4. The Use of Thrombopoietin Receptor Agonists for Correction of Thrombocytopenia prior to Elective Procedures in Chronic Liver Diseases: Review of Current Evidence

    PubMed Central

    Meillier, Andrew

    2016-01-01

    Patients with chronic liver diseases (CLD) undergo a range of invasive procedures during their clinical lifetime. Various hemostatic abnormalities are frequently identified during the periprocedural work-up; including thrombocytopenia. Thrombocytopenia of cirrhosis is multifactorial in origin, and decreased activity of thrombopoietin has been identified to be a major cause. Liver is an important site of thrombopoietin production and its levels are decreased in patients with cirrhosis. Severe thrombocytopenia (platelet counts < 60–75,000/µL) is associated with increased risk of bleeding with invasive procedures. In recent years, compounds with thrombopoietin receptor agonist activity have been studied as therapeutic options to raise platelet counts in CLD. We reviewed the use of Eltrombopag, Romiplostim, and Avatrombopag prior to various invasive procedures in patients with CLD. These agents seem promising in raising platelet counts before elective procedures resulting in reduction in platelet transfusions, and they also enabled more patients to undergo the procedures. However, these studies were not primarily aimed at comparing bleeding episodes among groups. Use of these agents had some adverse consequences, importantly being the occurrence of portal vein thrombosis. This review highlights the need of further studies to identify reliable methods of safely reducing the provoked bleeding risk linked to thrombocytopenia in CLD. PMID:27800187

  5. Use of complementary and alternative medical interventions for the management of procedure-related pain, anxiety, and distress in pediatric oncology: an integrative review.

    PubMed

    Landier, Wendy; Tse, Alice M

    2010-12-01

    This integrative review aims to identify evidence in four electronic databases (MEDLINE, CINAHL, PsyINFO, and COCHRANE) regarding the effectiveness of complementary and alternative medical interventions, either alone or as an adjunct to pharmacological therapy, in alleviating procedure-related pain, anxiety, and distress in children and adolescents with cancer. A total of 32 articles met inclusion criteria. Results suggest that mind-body interventions, including hypnosis, distraction, and imagery, may be effective, alone or as adjuncts to pharmacological interventions, in managing procedure-related pain, anxiety, and distress in pediatric oncology.

  6. Use of Complementary and Alternative Medical Interventions for the Management of Procedure-Related Pain, Anxiety, and Distress in Pediatric Oncology: An Integrative Review

    PubMed Central

    Landier, Wendy; Tse, Alice M.

    2016-01-01

    This integrative review aims to identify evidence in four electronic databases (MEDLINE, CINAHL, PsyINFO, and COCHRANE) regarding the effectiveness of complementary and alternative medical interventions, either alone or as an adjunct to pharmacological therapy, in alleviating procedure-related pain, anxiety, and distress in children and adolescents with cancer. A total of 32 articles met inclusion criteria. Results suggest that mind–body interventions, including hypnosis, distraction, and imagery, may be effective, alone or as adjuncts to pharmacological interventions, in managing procedure-related pain, anxiety, and distress in pediatric oncology. PMID:21035021

  7. 75 FR 29996 - Review of MMS NEPA Policies, Practices, and Procedures for OCS Oil and Gas Exploration and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... procedures is being conducted as a result of the oil spill from the Deepwater Horizon well and drilling rig... production. In line with CEQ's effort to engage the public in the NEPA process and the President's Open... by CEQ as well as on current MMS NEPA policies, practices, and procedures regarding Outer...

  8. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 690.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... chairperson from among members of the IRB. In reviewing the research, the reviewers may exercise all of...

  9. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 690.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... chairperson from among members of the IRB. In reviewing the research, the reviewers may exercise all of...

  10. 45 CFR 690.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 690.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... chairperson from among members of the IRB. In reviewing the research, the reviewers may exercise all of...

  11. 36 CFR 1260.58 - What are the procedures for requesting a mandatory review of White House originated information?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requesting a mandatory review of White House originated information? 1260.58 Section 1260.58 Parks, Forests... review of White House originated information? (a) Requests for mandatory review must describe the...) NARA will promptly acknowledge to the requester the receipt of a request for White House...

  12. Beyond Synthesis: Augmenting Systematic Review Procedures with Practical Principles to Optimise Impact and Uptake in Educational Policy and Practice

    ERIC Educational Resources Information Center

    Green, Chris; Taylor, Celia; Buckley, Sharon; Hean, Sarah

    2016-01-01

    Whilst systematic reviews, meta-analyses and other forms of synthesis are considered amongst the most valuable forms of research evidence, their limited impact on educational policy and practice has been criticised. In this article, we analyse why systematic reviews do not benefit users of evidence more consistently and suggest how review teams…

  13. The modified Kidner-Cobb procedure for symptomatic flexible pes planovalgus and posterior tibial tendon dysfunction stage II: review of 50 feet in 39 patients.

    PubMed

    Giorgini, Renato; Giorgini, Tara; Calderaro, Michele; Japour, Christopher; Cortes, Jane; Kim, David

    2010-01-01

    Symptomatic flatfoot is a prevalent disorder. We undertook a review of 50 feet in 39 patients with flexible flatfoot treated between August 2000 and January 2008 in order to evaluate the modified Kidner-Cobb procedure. Overall clinical results were rated as good in 48 (96%) feet and fair in 2 (4%) feet, and there were no poor results. Average follow-up was 4.6 years, and total recovery time was 5.7 months in older patients and 3.7 months in children. Manual muscle-strength testing revealed no difference in tibialis anterior strength between the operated and contralateral extremity. All patients visually demonstrated postoperative elevation of the medial longitudinal arch height. Complications included 2 feet with wound dehiscence and 1 foot with fractured hardware. The results of this review indicate that the modified Kidner-Cobb procedure is a useful treatment option for patients with symptomatic flexible flatfoot with posterior tibial tendon dysfunction stage 2. PMID:20797583

  14. The PriA Replication Restart Protein Blocks Replicase Access Prior to Helicase Assembly and Directs Template Specificity through Its ATPase Activity*

    PubMed Central

    Manhart, Carol M.; McHenry, Charles S.

    2013-01-01

    The PriA protein serves as an initiator for the restart of DNA replication on stalled replication forks and as a checkpoint protein that prevents the replicase from advancing in a strand displacement reaction on forks that do not contain a functional replicative helicase. We have developed a primosomal protein-dependent fluorescence resonance energy transfer (FRET) assay using a minimal fork substrate composed of synthetic oligonucleotides. We demonstrate that a self-loading reaction, which proceeds at high helicase concentrations, occurs by threading of a preassembled helicase over free 5′-ends, an event that can be blocked by attaching a steric block to the 5′-end or coating DNA with single-stranded DNA binding protein. The specificity of PriA for replication forks is regulated by its intrinsic ATPase. ATPase-defective PriA K230R shows a strong preference for substrates that contain no gap between the leading strand and the duplex portion of the fork, as demonstrated previously. Wild-type PriA prefers substrates with larger gaps, showing maximal activity on substrates on which PriA K230R is inactive. We demonstrate that PriA blocks replicase function on forks by blocking its binding. PMID:23264623

  15. Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis.

    PubMed

    Chaulk, Steven G; Thede, Gina L; Kent, Oliver A; Xu, Zhizhong; Gesner, Emily M; Veldhoen, Richard A; Khanna, Suneil K; Goping, Ing Swie; MacMillan, Andrew M; Mendell, Joshua T; Young, Howard S; Fahlman, Richard P; Glover, J N Mark

    2011-01-01

    MicroRNAs (miRNAs) regulate gene expression in a variety of biological pathways such as development and tumourigenesis. miRNAs are initially expressed as long primary transcripts (pri-miRNAs) that undergo sequential processing by Drosha and then Dicer to yield mature miRNAs. miR-17~92 is a miRNA cluster that encodes 6 miRNAs and while it is essential for development it also has reported oncogenic activity. To date, the role of RNA structure in miRNA biogenesis has only been considered in terms of the secondary structural elements required for processing of pri-miRNAs by Drosha. Here we report that the miR-17~92 cluster has a compact globular tertiary structure where miRNAs internalized within the core of the folded structure are processed less efficiently than miRNAs on the surface of the structure. Increased miR-92 expression resulting from disruption of the compact miR-17~92 structure results in increased repression of integrin α5 mRNA, a known target of miR-92a. In summary, we describe the first example of pri-miRNA structure modulating differential expression of constituent miRNAs.

  16. siRNA release from pri-miRNA scaffolds is controlled by the sequence and structure of RNA.

    PubMed

    Galka-Marciniak, Paulina; Olejniczak, Marta; Starega-Roslan, Julia; Szczesniak, Michal W; Makalowska, Izabela; Krzyzosiak, Wlodzimierz J

    2016-04-01

    shmiRs are pri-miRNA-based RNA interference triggers from which exogenous siRNAs are expressed in cells to silence target genes. These reagents are very promising tools in RNAi in vivo applications due to their good activity profile and lower toxicity than observed for other vector-based reagents such as shRNAs. In this study, using high-resolution northern blotting and small RNA sequencing, we investigated the precision with which RNases Drosha and Dicer process shmiRs. The fidelity of siRNA release from the commonly used pri-miRNA shuttles was found to depend on both the siRNA insert and the pri-miR scaffold. Then, we searched for specific factors that may affect the precision of siRNA release and found that both the structural features of shmiR hairpins and the nucleotide sequence at Drosha and Dicer processing sites contribute to cleavage site selection and cleavage precision. An analysis of multiple shRNA intermediates generated from several reagents revealed the complexity of shmiR processing by Drosha and demonstrated that Dicer selects substrates for further processing. Aside from providing new basic knowledge regarding the specificity of nucleases involved in miRNA biogenesis, our results facilitate the rational design of more efficient genetic reagents for RNAi technology. PMID:26921501

  17. Pain management in the neonatal piglet during routine management procedures. Part 1: a systematic review of randomized and non-randomized intervention studies.

    PubMed

    Dzikamunhenga, R S; Anthony, R; Coetzee, J; Gould, S; Johnson, A; Karriker, L; McKean, J; Millman, S T; Niekamp, S R; O'Connor, A M

    2014-06-01

    Routine procedures carried out on piglets (i.e. castration, tail docking, teeth clipping, and ear notching) are considered painful. Unfortunately the efficacy of current pain mitigation modalities is poorly understood. The aim of this systematic review was to synthesize the existing primary scientific literature regarding the effectiveness of pain management interventions used for routine procedures on piglets. The review question was, 'In piglets under twenty-eight days old, undergoing castration, tail docking, teeth clipping, and/or methods of identification that involve cutting of the ear tissue, what is the effect of pain mitigation compared with no pain mitigation on behavioral and non-behavioral outcomes that indicate procedural pain and post-procedural pain?' A review protocol was designed a priori. Data sources used were Agricola (EBSCO), CAB Abstracts (Thomson Reuters), PubMed, Web of Science (Thomson Reuters), BIOSIS Previews (Thomson Reuters), and ProQuest Dissertations & Theses Full Text. No restrictions on year of publication or language were placed on the search. Eligible studies assessed an intervention designed to mitigate the pain of the procedures of interest and included a comparison group that did not receive an intervention. Eligible non-English studies were translated using a translation service. Two reviewers independently screened titles and abstracts for relevance using pre-defined questions. Data were extracted from relevant articles onto pre-defined forms. From the 2203 retrieved citations forty publications, containing 52 studies met the eligibility criteria. In 40 studies, piglets underwent castration only. In seven studies, piglets underwent tail docking only. In one study, piglets underwent teeth clipping only, and in one study piglets underwent ear notching only. Three studies used multiple procedures. Thirty-two trial arms assessed general anesthesia protocols, 30 trial arms assessed local anesthetic protocols, and 28 trial arms

  18. Developing policies and procedures.

    PubMed

    Randolph, Susan A

    2006-11-01

    The development of policies and procedures is an integral part of the occupational health nurse's role. Policies and procedures serve as the foundation for the occupational health service and are based on its vision, mission, culture, and values. The design and layout selected for the policies and procedures should be simple, consistent, and easy to use. The same format should be used for all existing and new policies and procedures. Policies and procedures should be reviewed periodically based on a specified time frame (i.e., annually). However, some policies may require a more frequent review if they involve rapidly changing external standards, ethical issues, or emerging exposures. PMID:17124968

  19. 36 CFR 1260.52 - What are the procedures when agency personnel review records in NARA's legal and physical custody?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... agency personnel review records in NARA's legal and physical custody? 1260.52 Section 1260.52 Parks... agency personnel review records in NARA's legal and physical custody? (a) NARA will: (1) Make the records... require exemption, referral, or exclusion in accordance with section 3.3 of the Order or 32 CFR...

  20. 36 CFR 1260.52 - What are the procedures when agency personnel review records in NARA's legal and physical custody?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... agency personnel review records in NARA's legal and physical custody? 1260.52 Section 1260.52 Parks... agency personnel review records in NARA's legal and physical custody? (a) NARA will: (1) Make the records... require exemption, referral, or exclusion in accordance with section 3.3 of the Order or 32 CFR...

  1. 36 CFR 1260.52 - What are the procedures when agency personnel review records in NARA's legal and physical custody?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... agency personnel review records in NARA's legal and physical custody? 1260.52 Section 1260.52 Parks... agency personnel review records in NARA's legal and physical custody? (a) NARA will: (1) Make the records... require exemption, referral, or exclusion in accordance with section 3.3 of the Order or 32 CFR...

  2. Registering medicines for low-income countries: how suitable are the stringent review procedures of the World Health Organisation, the US Food and Drug Administration and the European Medicines Agency?

    PubMed

    Doua, Joachim Y; Van Geertruyden, Jean-Pierre

    2014-01-01

    New medicines are registered after a resource-demanding process. Unfortunately, in low-income countries (LICs), demand outweighs resources. To facilitate registration in LICs, stringent review procedures of the European Medicines Agency (EMA Article-58), Food and Drug Administration (FDA PEPFAR-linked review) and WHO Prequalification programme have been established. Only the PEPFAR-linked review gives approval, while the others make recommendations for approval. This study assessed the performance and discussed the challenges of these three stringent review procedures. Data from WHO, FDA, EMA, Medline and Internet were analysed. Over 60% of medicines reviewed by stringent review procedures are manufactured in India. Until 2012, WHO prequalified 400 medicines (211 vaccines, 130 antiretrovirals, 29 tuberculostatics, 15 antimalarials and 15 others). PEPFAR-linked review approved 156 antiretrovirals, while EMA Article 58 recommended approval of 3 antiretrovirals, 1 vaccine and 1 antimalarial. WHO Prequalification and PEPFAR-linked review are free of charge and as a result have accelerated access to antiretrovirals. They both built capacity in sub-Saharan Africa, although WHO prequalification relies technically on stringent regulatory authorities and financially on donors. Article-58 offers the largest disease coverage and strongest technical capacities, is costly and involves fewer LICs. To meet the high demand for quality medicines in LICs, these stringent review procedures need to enlarge their disease coverage. To improve registration, EMA Article 58 should actively involve LICs. Furthermore, LIC regulatory activities must not be fully resigned to stringent review procedure.

  3. Quantitative Content Analysis Procedures to Analyse Students' Reflective Essays: A Methodological Review of Psychometric and Edumetric Aspects

    ERIC Educational Resources Information Center

    Poldner, E.; Simons, P. R. J.; Wijngaards, G.; van der Schaaf, M. F.

    2012-01-01

    Reflective essays are a common way to develop higher education students' reflection ability. Researchers frequently analyse reflective essays based on quantitative content analysis procedures (QCA). However, the quality criteria that should be met in QCA are not straightforward. This article aims to: (1) develop a framework of quality requirements…

  4. Binding Specificity of E. coli SSB protein for the χ subunit of DNA pol III Holoenzyme and PriA helicase.†

    PubMed Central

    Kozlov, Alexander G.; Jezewska, Maria J.; Bujalowski, Wlodzimierz; Lohman, Timothy M.

    2010-01-01

    The E. coli single stranded DNA binding (SSB) protein plays a central role in DNA metabolism through its high affinity interactions with ssDNA, as well as its interactions with numerous other proteins via its unstructured C-termini. Although SSB interacts with at least 14 other proteins, it is not understood how SSB might recruit one protein over another for a particular metabolic role. To probe the specificity of these interactions we have used isothermal titration calorimetry to examine the thermodynamics of binding of SSB to two E. coli proteins important for DNA replication, the χ subunit of DNA polymerase III holoenzyme and the PriA helicase. We find that an SSB tetramer can bind up to four molecules of either protein primarily via interactions with the last ~ 9 amino acids in the conserved SSB C-terminal tails (SSB-Ct). We observe intrinsic specificity for the binding of an isolated SSB-Ct peptide to PriA over χ due primarily to a more favorable enthalpic component. PriA and χ also bind with weaker affinity to SSB (in the absence of ssDNA) than to isolated SSB-Ct peptides, indicating an inhibitory effect of the SSB protein core. Although the binding affinity of SSB for both χ and PriA is enhanced if SSB is prebound to ssDNA, this effect is larger with PriA indicating a further enhancement of SSB specificity for PriA. These results also suggest that DNA binding proteins such as PriA, which also interact with SSB, could use this interaction to gain access to ssDNA by first interacting with the SSB C-termini. PMID:20329707

  5. Periprocedural management of anticoagulation in patients taking novel oral anticoagulants: Review of the literature and recommendations for specific populations and procedures.

    PubMed

    Mar, Philip L; Familtsev, Dmitry; Ezekowitz, Michael D; Lakkireddy, Dhanunjaya; Gopinathannair, Rakesh

    2016-01-01

    An increasing number of individuals are on novel oral anticoagulants (NOAC) for anticoagulation instead of vitamin K antagonists (VKA) and roughly 10% of these individuals will require interruption of these agents for procedures annually. Recent evidence surrounding bridging as well as the FDA approval of a new NOAC call for a comprehensive review and update regarding periprocedural NOAC management. The periprocedural management of NOACs involves striking a balance between the risks of bleeding and thromboembolism associated with interruption, bridging, and reinitiation of anticoagulation. NOACs have a distinct pharmacokinetic advantage in this setting with their quick onset and elimination from the body. Procedures at low risk for bleeding do not require interruption and can be scheduled at the start of the next dosing interval. Procedures at moderate-high risk of bleeding require interruption of NOAC for 5 half lives prior to the procedure to allow for adequate elimination of the drug. In light of new evidence highlighting the risks of bleeding, and given shorter "unprotected" times with NOAC interruption versus VKA, patients at low-moderate risk for thromboembolism should not be bridged when "unprotected" time is less than 96 h. For patients at high risk for thromboembolism, individual patient and surgical factors need to be considered before the decision to bridge is made. The benefit of bridging these patients who have a considerable risk of bleeding may not outweigh the benefits. Focused randomized studies on periprocedural management of NOACs are urgently needed. PMID:26447666

  6. Hypnosis for procedure-related pain and distress in pediatric cancer patients: a systematic review of effectiveness and methodology related to hypnosis interventions.

    PubMed

    Richardson, Janet; Smith, Joanna E; McCall, Gillian; Pilkington, Karen

    2006-01-01

    The aim of this study was to systematically review and critically appraise the evidence on the effectiveness of hypnosis for procedure-related pain and distress in pediatric cancer patients. A comprehensive search of major biomedical and specialist complementary and alternative medicine databases was conducted. Citations were included from the databases' inception to March 2005. Efforts were made to identify unpublished and ongoing research. Controlled trials were appraised using predefined criteria. Clinical commentaries were obtained for each study. Seven randomized controlled clinical trials and one controlled clinical trial were found. Studies report positive results, including statistically significant reductions in pain and anxiety/distress, but a number of methodological limitations were identified. Systematic searching and appraisal has demonstrated that hypnosis has potential as a clinically valuable intervention for procedure-related pain and distress in pediatric cancer patients. Further research into the effectiveness and acceptability of hypnosis for pediatric cancer patients is recommended. PMID:16442484

  7. 36 CFR 1260.58 - What are the procedures for requesting a mandatory review of White House originated information?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... information. (e) If the requested information is less than 25 years old, NARA will consult with agencies... more than 25 years old, NARA will review the records using systematic declassification guidance... declassification within the past 2 years, or if the specific information is the subject of pending litigation,...

  8. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE...

  9. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE...

  10. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE...

  11. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Federal Register, legal notice in one or more newspapers of general circulation, or press release. The.... This may include, but is not limited to, legal notice in a newspaper of general circulation or press release. The public shall have a minimum of 30 calendar days to review and comment on the proposal....

  12. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Federal Register, legal notice in one or more newspapers of general circulation, or press release. The.... This may include, but is not limited to, legal notice in a newspaper of general circulation or press release. The public shall have a minimum of 30 calendar days to review and comment on the proposal....

  13. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Federal Register, legal notice in one or more newspapers of general circulation, or press release. The.... This may include, but is not limited to, legal notice in a newspaper of general circulation or press release. The public shall have a minimum of 30 calendar days to review and comment on the proposal....

  14. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Federal Register, legal notice in one or more newspapers of general circulation, or press release. The.... This may include, but is not limited to, legal notice in a newspaper of general circulation or press release. The public shall have a minimum of 30 calendar days to review and comment on the proposal....

  15. 36 CFR 216.6 - Notice and comment procedures for proposed Manual directives identified for formal public review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Federal Register, legal notice in one or more newspapers of general circulation, or press release. The.... This may include, but is not limited to, legal notice in a newspaper of general circulation or press release. The public shall have a minimum of 30 calendar days to review and comment on the proposal....

  16. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC... and Approving Abandonment under Section 7 of the Natural Gas Act, as Amended, Concerning Any...

  17. 18 CFR 157.21 - Pre-filing procedures and review process for LNG terminal facilities and other natural gas...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... and review process for LNG terminal facilities and other natural gas facilities prior to filing of... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC... and Approving Abandonment under Section 7 of the Natural Gas Act, as Amended, Concerning Any...

  18. Maximizing the Effectiveness of Structured Classroom Management Programs: Implementing Rule-Review Procedures with Disruptive and Distractible Students.

    ERIC Educational Resources Information Center

    Rosenberg, Michael S.

    1986-01-01

    Results of a study of five subjects (ages 7-9) in a multicategorical resource room employing a token economy indicated that the addition of a daily review of classroom rules resulted in an overall time-on-task improvement of 12% and a 50% reduction of instances of disruptive "talkout." (Author/JW)

  19. Nerve Retraction During Inferior Alveolar Nerve Repositioning Procedure: A New Simple Method and Review of the Literature.

    PubMed

    Hassani, Ali; Saadat, Sarang; Moshiri, Roya; Shahmirzad, Solaleh; Hassani, Amin

    2015-07-01

    Nerve repositioning surgery is one of the treatments chosen for the patients with edentulous posterior atrophic mandible. Like any other treatments, this therapy has its advantages and disadvantages, indications and contraindications. The most important complication of this procedure is neurosensory disturbance. This problem may occur at different stages of the treatment. One common time when nerve damage happens is when the nerve is located outside the canal and drilling and insertion of the implant are performed. Accordingly, this report describes a simple and feasible method to retract and protect nerves outside the canal during the treatment of nerve transposition. This will reduce the risk of nerve damage. PMID:24344674

  20. Overlapping functions for recF and priA in cell viability and UV-inducible SOS expression are distinguished by dnaC809 in Escherichia coli K-12.

    PubMed

    Sandler, S J

    1996-02-01

    The recF and priA genes have roles in DNA repair and homologous recombination. Mutations in these genes also cause decreases in cell viability and alterations in UV-inducible sulAp-lacZ (SOS) expression. To find out if the two genes are in the same or different pathways for viability and SOS expression, the phenotypes of the double mutant strains were studied. The recF priA double mutant showed a lower viability and SOS expression level than either of the single mutants. In the case of cell viability, recF missense mutations decreased viability of a priA2::kan strain two to five-fold whereas recF null priA2::kan double mutants were not viable at all. dnaC809, a mutation that suppresses the UV-sensitive (UVs and Rec- phenotypes of priA2::kan, restored cell viability, but not UV-inducible SOS expression, to a priA recF strain. Since recF is epistatic with recO and recR (recOR) for UV resistance, recOR mutations were also tested with priA2::kan. No overlap was found between recOR and priA for viability and SOS expression. It is concluded that priA and recF have two different overlapping functions in viability and SOS expression that are distinguishable by the effects of dnaC809. The role of recF in a priA2::kan strain in cell viability is a new function for recF and unlike recF's other roles in DNA repair and recombination, is independent of recOR. A new role for priA in UV-inducible SOS expression in a recF mutant is also defined. PMID:8820655