Carrender, Curtis Lee; Gilbert, Ronald W.
2007-02-20
A radio frequency (RF) communication system employs phase-modulated backscatter signals for RF communication from an RF tag to an interrogator. The interrogator transmits a continuous wave interrogation signal to the RF tag, which based on an information code stored in a memory, phase-modulates the interrogation signal to produce a backscatter response signal that is transmitted back to the interrogator. A phase modulator structure in the RF tag may include a switch coupled between an antenna and a quarter-wavelength stub; and a driver coupled between the memory and a control terminal of the switch. The driver is structured to produce a modulating signal corresponding to the information code, the modulating signal alternately opening and closing the switch to respectively decrease and increase the transmission path taken by the interrogation signal and thereby modulate the phase of the response signal. Alternatively, the phase modulator may include a diode coupled between the antenna and driver. The modulating signal from the driver modulates the capacitance of the diode, which modulates the phase of the response signal reflected by the diode and antenna.
DETECTOR FOR MODULATED AND UNMODULATED SIGNALS
Patterson, H.H.; Webber, G.H.
1959-08-25
An r-f signal-detecting device is described, which is embodied in a compact coaxial circuit principally comprising a detecting crystal diode and a modulating crystal diode connected in parallel. Incoming modulated r-f signals are demodulated by the detecting crystal diode to furnish an audio input to an audio amplifier. The detecting diode will not, however, produce an audio signal from an unmodulated r-f signal. In order that unmodulated signals may be detected, such incoming signals have a locally produced audio signal superimposed on them at the modulating crystal diode and then the"induced or artificially modulated" signal is reflected toward the detecting diode which in the process of demodulation produces an audio signal for the audio amplifier.
NASA Astrophysics Data System (ADS)
Isoe, G. M.; Wassin, S.; Gamatham, R. R. G.; Leitch, A. W. R.; Gibbon, T. B.
2017-11-01
Optical fibre communication technologies are playing important roles in data centre networks (DCNs). Techniques for increasing capacity and flexibility for the inter-rack/pod communications in data centres have drawn remarkable attention in recent years. In this work, we propose a low complexity, reliable, alternative technique for increasing DCN capacity and flexibility through multi-signal modulation onto a single mode VCSEL carrier. A 20 Gbps 4-PAM data signal is directly modulated on a single mode 10 GHz bandwidth VCSEL carrier at 1310 nm, therefore, doubling the network bit rate. Carrier spectral efficiency is further maximized by modulating its phase attribute with a 2 GHz reference frequency (RF) clock signal. We, therefore, simultaneously transmit a 20 Gbps 4-PAM data signal and a phase modulated 2 GHz RF signal using a single mode 10 GHz bandwidth VCSEL carrier. It is the first time a single mode 10 GHz bandwidth VCSEL carrier is reported to simultaneously transmit a directly modulated 4-PAM data signal and a phase modulated RF clock signal. A receiver sensitivity of -10. 52 dBm was attained for a 20 Gbps 4-PAM VCSEL transmission. The 2 GHz phase modulated RF clock signal introduced a power budget penalty of 0.21 dB. Simultaneous distribution of both data and timing signals over shared infrastructure significantly increases the aggregated data rate at different optical network units within the DCN, without expensive optics investment. We further demonstrate on the design of a software-defined digital signal processing assisted receiver to efficiently recover the transmitted signal without employing costly receiver hardware.
Transmission of RF Signals Over Optical Fiber for Avionics Applications
NASA Technical Reports Server (NTRS)
Slaveski, Filip; Sluss, James, Jr.; Atiquzzaman, Mohammed; Hung, Nguyen; Ngo, Duc
2002-01-01
During flight, aircraft avionics transmit and receive RF signals to/from antennas over coaxial cables. As the density and complexity of onboard avionics increases, the electromagnetic interference (EM) environment degrades proportionately, leading to decreasing signal-to-noise ratios (SNRs) and potential safety concerns. The coaxial cables are inherently lossy, limiting the RF signal bandwidth while adding considerable weight. To overcome these limitations, we have investigated a fiber optic communications link for aircraft that utilizes wavelength division multiplexing (WDM) to support the simultaneous transmission of multiple signals (including RF) over a single optical fiber. Optical fiber has many advantages over coaxial cable, particularly lower loss, greater bandwidth, and immunity to EM. In this paper, we demonstrate that WDM can be successfully used to transmit multiple RF signals over a single optical fiber with no appreciable signal degradation. We investigate the transmission of FM and AM analog modulated signals, as well as FSK digital modulated signals, over a fiber optic link (FOL) employing WDM. We present measurements of power loss, delay, SNR, carrier-to-noise ratio (CNR), total harmonic distortion (THD), and bit error rate (BER). Our experimental results indicate that WDM is a fiber optic technology suitable for avionics applications.
RF signal detection by a tunable optoelectronic oscillator based on a PS-FBG.
Shao, Yuchen; Han, Xiuyou; Li, Ming; Zhao, Mingshan
2018-03-15
Low-power radio frequency (RF) signal detection is highly desirable for many applications, ranging from wireless communication to radar systems. A tunable optoelectronic oscillator (OEO) based on a phase-shifted fiber Bragg grating for detecting low-power RF signals is proposed and experimentally demonstrated. When the frequency of the input RF signal is matched with the potential oscillation mode of the OEO, it is detected and amplified. The frequency of the RF signal under detection can be estimated simultaneously by scanning the wavelength of the laser source. The RF signals from 1.5 to 5 GHz as low as -91 dBm are detected with a gain of about 10 dB, and the frequency is estimated with an error of ±100 MHz. The performance of the OEO system for detecting an RF signal with different modulation rates is also investigated.
Wide-band analog frequency modulation of optic signals using indirect techniques
NASA Technical Reports Server (NTRS)
Fitzmartin, D. J.; Balboni, E. J.; Gels, R. G.
1991-01-01
The wideband frequency modulation (FM) of an optical carrier by a radio frequency (RF) or microwave signal can be accomplished independent of laser type when indirect modulation is employed. Indirect modulators exploit the integral relation of phase to frequency so that phase modulators can be used to impress frequency modulation on an optical carrier. The use of integrated optics phase modulators, which are highly linear, enables the generation of optical wideband FM signals with very low intermodulation distortion. This modulator can be used as part of an optical wideband FM link for RF and microwave signals. Experimental results from the test of an indirect frequency modulator for an optical carrier are discussed.
Integrated optical modulator for signal up-conversion over radio-on-fiber link.
Kim, Woo-Kyung; Kwon, Soon-Woo; Jeong, Woo-Jin; Son, Geun-Sik; Lee, Kwang-Hyun; Choi, Woo-Young; Yang, Woo-Seok; Lee, Hyung-Man; Lee, Han-Young
2009-02-16
An integrated optical modulator, which consists of a dual-sideband suppressed carrier (DSB-SC) modulator cascaded with a single-sideband (SSB) modulator, is proposed for signal up-conversion over Radio-on-Fiber. Utilizing a single-drive domain inverted structure in both modulators, balanced modulations were obtained without complicated radio frequency (RF) driving circuits and delicate RF phase adjustments. Intermediate frequency (IF) band signal was up-conversed to 60GHz band by using the fabricated device and was transmitted over optical fiber. Experiment results show that the proposed device enables millimeter wave generation and signal transmission without any power penalty caused by chromatic dispersion.
Multi-level RF identification system
Steele, Kerry D.; Anderson, Gordon A.; Gilbert, Ronald W.
2004-07-20
A radio frequency identification system having a radio frequency transceiver for generating a continuous wave RF interrogation signal that impinges upon an RF identification tag. An oscillation circuit in the RF identification tag modulates the interrogation signal with a subcarrier of a predetermined frequency and modulates the frequency-modulated signal back to the transmitting interrogator. The interrogator recovers and analyzes the subcarrier signal and determines its frequency. The interrogator generates an output indicative of the frequency of the subcarrier frequency, thereby identifying the responding RFID tag as one of a "class" of RFID tags configured to respond with a subcarrier signal of a predetermined frequency.
RF to millimeter wave integration and module technologies
NASA Astrophysics Data System (ADS)
Vähä-Heikkilä, T.
2015-04-01
Radio Frequency (RF) consumer applications have boosted silicon integrated circuits (IC) and corresponding technologies. More and more functions are integrated to ICs and their performance is also increasing. However, RF front-end modules with filters and switches as well as antennas still need other way of integration. This paper focuses to RF front-end module and antenna developments as well as to the integration of millimeter wave radios. VTT Technical Research Centre of Finland has developed both Low Temperature Co-fired Ceramics (LTCC) and Integrated Passive Devices (IPD) integration platforms for RF and millimeter wave integrated modules. In addition to in-house technologies, VTT is using module and component technologies from other commercial sources.
Low cost high efficiency GaAs monolithic RF module for SARSAT distress beacons
NASA Technical Reports Server (NTRS)
Petersen, W. C.; Siu, D. P.; Cook, H. F.
1991-01-01
Low cost high performance (5 Watts output) 406 MHz beacons are urgently needed to realize the maximum utilization of the Search and Rescue Satellite-Aided Tracking (SARSAT) system spearheaded in the U.S. by NASA. Although current technology can produce beacons meeting the output power requirement, power consumption is high due to the low efficiency of available transmitters. Field performance is currently unsatisfactory due to the lack of safe and reliable high density batteries capable of operation at -40 C. Low cost production is also a crucial but elusive requirement for the ultimate wide scale utilization of this system. Microwave Monolithics Incorporated (MMInc.) has proposed to make both the technical and cost goals for the SARSAT beacon attainable by developing a monolithic GaAs chip set for the RF module. This chip set consists of a high efficiency power amplifier and a bi-phase modulator. In addition to implementing the RF module in Monolithic Microwave Integrated Circuit (MMIC) form to minimize ultimate production costs, the power amplifier has a power-added efficiency nearly twice that attained with current commercial technology. A distress beacon built using this RF module chip set will be significantly smaller in size and lighter in weight due to a smaller battery requirement, since the 406 MHz signal source and the digital controller have far lower power consumption compared to the 5 watt power amplifier. All the program tasks have been successfully completed. The GaAs MMIC RF module chip set has been designed to be compatible with the present 406 MHz signal source and digital controller. A complete high performance low cost SARSAT beacon can be realized with only additional minor iteration and systems integration.
RF Jitter Modulation Alignment Sensing
NASA Astrophysics Data System (ADS)
Ortega, L. F.; Fulda, P.; Diaz-Ortiz, M.; Perez Sanchez, G.; Ciani, G.; Voss, D.; Mueller, G.; Tanner, D. B.
2017-01-01
We will present the numerical and experimental results of a new alignment sensing scheme which can reduce the complexity of alignment sensing systems currently used, while maintaining the same shot noise limited sensitivity. This scheme relies on the ability of electro-optic beam deflectors to create angular modulation sidebands in radio frequency, and needs only a single-element photodiode and IQ demodulation to generate error signals for tilt and translation degrees of freedom in one dimension. It distances itself from current techniques by eliminating the need for beam centering servo systems, quadrant photodetectors and Gouy phase telescopes. RF Jitter alignment sensing can be used to reduce the complexity in the alignment systems of many laser optical experiments, including LIGO and the ALPS experiment.
Spurious RF signals emitted by mini-UAVs
NASA Astrophysics Data System (ADS)
Schleijpen, Ric (H. M. A.); Voogt, Vincent; Zwamborn, Peter; van den Oever, Jaap
2016-10-01
This paper presents experimental work on the detection of spurious RF emissions of mini Unmanned Aerial Vehicles (mini-UAV). Many recent events have shown that mini-UAVs can be considered as a potential threat for civil security. For this reason the detection of mini-UAVs has become of interest to the sensor community. The detection, classification and identification chain can take advantage of different sensor technologies. Apart from the signatures used by radar and electro-optical sensor systems, the UAV also emits RF signals. These RF signatures can be split in intentional signals for communication with the operator and un-intentional RF signals emitted by the UAV. These unintentional or spurious RF emissions are very weak but could be used to discriminate potential UAV detections from false alarms. The goal of this research was to assess the potential of exploiting spurious emissions in the classification and identification chain of mini-UAVs. It was already known that spurious signals are very weak, but the focus was on the question whether the emission pattern could be correlated to the behaviour of the UAV. In this paper experimental examples of spurious RF emission for different types of mini-UAVs and their correlation with the electronic circuits in the UAVs will be shown
BPSK optical mm-wave signal generation by septupling frequency via a single optical phase modulator
NASA Astrophysics Data System (ADS)
Wu, Peng; Ma, Jianxin
2016-09-01
In this paper, we have proposed a novel and simple scheme to generate the BPSK optical millimeter wave (MMW) signal with frequency septupling by using an optical phase modulator (PM) and a wavelength selective switch (WSS). In this scheme, the PM is driven by a radio frequency (RF) BPSK signal at the optimized modulation index of 4.89 to assure the 4th and 3rd-order sidebands have equal amplitudes. An wavelength selective switch (WSS) is used to abstract the -4th and +3rd-order sidebands from the spectrum generated by RF BPSK signal modulating the lightwave to form the BPSK optical MMW signal with frequency septupling the driving RF signal. In these two tones, only the +3rd-order sideband bears the BPSK signal while the -4th-order sideband is unmodulated since the phase information is canceled by the even times multiplication of the phase of BPSK signal. The MMW signal can avoid the pulse walk-off effect and the amplitude fading effect caused by the fiber chromatic dispersion. By adjusting the modulation index to assure the two tones have equal amplitude, the generated optical MMW signal has the maximal opto-electrical conversion efficiency and good transmission performance.
NASA Astrophysics Data System (ADS)
Siddiqui, Aleem; Reinke, Charles; Shin, Heedeuk; Jarecki, Robert L.; Starbuck, Andrew L.; Rakich, Peter
2017-05-01
The performance of electronic systems for radio-frequency (RF) spectrum analysis is critical for agile radar and communications systems, ISR (intelligence, surveillance, and reconnaissance) operations in challenging electromagnetic (EM) environments, and EM-environment situational awareness. While considerable progress has been made in size, weight, and power (SWaP) and performance metrics in conventional RF technology platforms, fundamental limits make continued improvements increasingly difficult. Alternatively, we propose employing cascaded transduction processes in a chip-scale nano-optomechanical system (NOMS) to achieve a spectral sensor with exceptional signal-linearity, high dynamic range, narrow spectral resolution and ultra-fast sweep times. By leveraging the optimal capabilities of photons and phonons, the system we pursue in this work has performance metrics scalable well beyond the fundamental limitations inherent to all electronic systems. In our device architecture, information processing is performed on wide-bandwidth RF-modulated optical signals by photon-mediated phononic transduction of the modulation to the acoustical-domain for narrow-band filtering, and then back to the optical-domain by phonon-mediated phase modulation (the reverse process). Here, we rely on photonics to efficiently distribute signals for parallel processing, and on phononics for effective and flexible RF-frequency manipulation. This technology is used to create RF-filters that are insensitive to the optical wavelength, with wide center frequency bandwidth selectivity (1-100GHz), ultra-narrow filter bandwidth (1-100MHz), and high dynamic range (70dB), which we will present. Additionally, using this filter as a building block, we will discuss current results and progress toward demonstrating a multichannel-filter with a bandwidth of < 10MHz per channel, while minimizing cumulative optical/acoustic/optical transduced insertion-loss to ideally < 10dB. These proposed metric
Compression and Transmission of RF Signals for Telediagnosis
NASA Astrophysics Data System (ADS)
Seko, Toshihiro; Doi, Motonori; Oshiro, Osamu; Chihara, Kunihiro
2000-05-01
Health care is a critical issue nowadays. Much emphasis is given to quality care for all people. Telediagnosis has attracted public attention. We propose a new method of ultrasound image transmission for telediagnosis. In conventional methods, video image signals are transmitted. In our method, the RF signals which are acquired by an ultrasound probe, are transmitted. The RF signals can be transformed to color Doppler images or high-resolution images by a receiver. Because a stored form is adopted, the proposed system can be realized with existent technology such as hyper text transfer protocol (HTTP) and file transfer protocol (FTP). In this paper, we describe two lossless compression methods which specialize in the transmission of RF signals. One of the methods uses the characteristics of the RF signal. In the other method, the amount of the data is reduced. Measurements were performed in water targeting an iron block and triangular Styrofoam. Additionally, abdominal fat measurement was performed. Our method achieved a compression rate of 13% with 8 bit data.
Connect Global Positioning System RF Module
NASA Technical Reports Server (NTRS)
Franklin, Garth W.; Young, Lawrence E.; Ciminera, Michael A.; Tien, Jeffrey Y.; Gorelik, Jacob; Okihiro, Brian Bachman; Koelewyn, Cynthia L.
2012-01-01
The CoNNeCT Global Positioning System RF Module (GPSM) slice is part of the JPL CoNNeCT Software Defined Radio (SDR). CoNNeCT is the Communications, Navigation, and Net working reconfigurable Testbed project that is part of NASA's Space Communication and Nav igation (SCaN) Program. The CoNNeCT project is an experimental dem onstration that will lead to the advancement of SDRs and provide a path for new space communication and navigation systems for future NASA exploration missions. The JPL CoNNeCT SDR will be flying on the International Space Station (ISS) in 2012 in support of the SCaN CoNNeCT program. The GPSM is a radio-frequency sampler module (see Figure 1) that directly sub-harmonically samples the filtered GPS L-band signals at L1 (1575.42 MHz), L2 (1227.6 MHz), and L5 (1176.45 MHz). The JPL SDR receives GPS signals through a Dorne & Margolin antenna mounted onto a choke ring. The GPS signal is filtered against interference, amplified, split, and fed into three channels: L1, L2, and L5. In each of the L-band channels, there is a chain of bandpass filters and amplifiers, and the signal is fed through each of these channels to where the GPSM performs a one-bit analog-to-digital conversion (see Figure 2). The GPSM uses a sub-harmonic, single-bit L1, L2, and L5 sampler that samples at a clock rate of 38.656 MHz. The new capability is the down-conversion and sampling of the L5 signal when previous hardware did not provide this capability. The first GPS IIF Satellite was launched in 2010, providing the new L5 signal. With the JPL SDR flying on the ISS, it will be possible to demonstrate navigation solutions with 10-meter 3-D accuracy at 10-second intervals using a field-program mable gate array (FPGA)-based feedback loop running at 50 Hz. The GPS data bits will be decoded and used in the SDR. The GPSM will also allow other waveforms that are installed in the SDR to demonstrate various GNSS tracking techniques.
Down-conversion IM-DD RF photonic link utilizing MQW MZ modulator.
Xu, Longtao; Jin, Shilei; Li, Yifei
2016-04-18
We present the first down-conversion intensity modulated-direct detection (IM-DD) RF photonic link that achieves frequency down-conversion using the nonlinear optical phase modulation inside a Mach-Zehnder (MZ) modulator. The nonlinear phase modulation is very sensitive and it can enable high RF-to-IF conversion efficiency. Furthermore, the link linearity is enhanced by canceling the nonlinear distortions from the nonlinear phase modulation and the MZ interferometer. Proof-of-concept measurement was performed. The down-conversion IM-DD link demonstrated 28dB improvement in distortion levels over that of a conventional IM-DD link using a LiNbO3 MZ modulator.
Digital processing of RF signals from optical frequency combs
NASA Astrophysics Data System (ADS)
Cizek, Martin; Smid, Radek; Buchta, Zdeněk.; Mikel, Břetislav; Lazar, Josef; Cip, Ondřej
2013-01-01
The presented work is focused on digital processing of beat note signals from a femtosecond optical frequency comb. The levels of mixing products of single spectral components of the comb with CW laser sources are usually very low compared to products of mixing all the comb components together. RF counters are more likely to measure the frequency of the strongest spectral component rather than a weak beat note. Proposed experimental digital signal processing system solves this problem by analyzing the whole spectrum of the output RF signal and using software defined radio (SDR) algorithms. Our efforts concentrate in two main areas: Firstly, using digital servo-loop techniques for locking free running continuous laser sources on single components of the fs comb spectrum. Secondly, we are experimenting with digital signal processing of the RF beat note spectrum produced by f-2f 1 technique used for assessing the offset and repetition frequencies of the comb, resulting in digital servo-loop stabilization of the fs comb. Software capable of computing and analyzing the beat-note RF spectrums using FFT and peak detection was developed. A SDR algorithm performing phase demodulation on the f- 2f signal is used as a regulation error signal source for a digital phase-locked loop stabilizing the offset frequency of the fs comb.
Magnetoplasmonic RF mixing and nonlinear frequency generation
DOE Office of Scientific and Technical Information (OSTI.GOV)
Firby, C. J., E-mail: firby@ualberta.ca; Elezzabi, A. Y.
2016-07-04
We present the design of a magnetoplasmonic Mach-Zehnder interferometer (MZI) modulator facilitating radio-frequency (RF) mixing and nonlinear frequency generation. This is achieved by forming the MZI arms from long-range dielectric-loaded plasmonic waveguides containing bismuth-substituted yttrium iron garnet (Bi:YIG). The magnetization of the Bi:YIG can be driven in the nonlinear regime by RF magnetic fields produced around adjacent transmission lines. Correspondingly, the nonlinear temporal dynamics of the transverse magnetization component are mapped onto the nonreciprocal phase shift in the MZI arms, and onto the output optical intensity signal. We show that this tunable mechanism can generate harmonics, frequency splitting, and frequencymore » down-conversion with a single RF excitation, as well as RF mixing when driven by two RF signals. This magnetoplasmonic component can reduce the number of electrical sources required to generate distinct optical modulation frequencies and is anticipated to satisfy important applications in integrated optics.« less
Highly Sensitive Electro-Optic Modulators
DOE Office of Scientific and Technical Information (OSTI.GOV)
DeVore, Peter S
2015-10-26
There are very important diagnostic and communication applications that receive faint electrical signals to be transmitted over long distances for capture. Optical links reduce bandwidth and distance restrictions of metal transmission lines; however, such signals are only weakly imprinted onto the optical carrier, resulting in low fidelity transmission. Increasing signal fidelity often necessitates insertion of radio-frequency (RF) amplifiers before the electro-optic modulator, but (especially at high frequencies) RF amplification results in large irreversible distortions. We have investigated the feasibility of a Sensitive and Linear Modulation by Optical Nonlinearity (SALMON) modulator to supersede RF-amplified modulators. SALMON uses cross-phase modulation, a manifestationmore » of the Kerr effect, to enhance the modulation depth of an RF-modulated optical wave. This ultrafast process has the potential to result in less irreversible distortions as compared to a RF-amplified modulator due to the broadband nature of the Kerr effect. Here, we prove that a SALMON modulator is a feasible alternative to an RFamplified modulator, by demonstrating a sensitivity enhancement factor greater than 20 and significantly reduced distortion.« less
Low jitter RF distribution system
Wilcox, Russell; Doolittle, Lawrence; Huang, Gang
2012-09-18
A timing signal distribution system includes an optical frequency stabilized laser signal amplitude modulated at an rf frequency. A transmitter box transmits a first portion of the laser signal and receive a modified optical signal, and outputs a second portion of the laser signal and a portion of the modified optical signal. A first optical fiber carries the first laser signal portion and the modified optical signal, and a second optical fiber carries the second portion of the laser signal and the returned modified optical signal. A receiver box receives the first laser signal portion, shifts the frequency of the first laser signal portion outputs the modified optical signal, and outputs an electrical signal on the basis of the laser signal. A detector at the end of the second optical fiber outputs a signal based on the modified optical signal. An optical delay sensing circuit outputs a data signal based on the detected modified optical signal. An rf phase detect and correct signal circuit outputs a signal corresponding to a phase stabilized rf signal based on the data signal and the frequency received from the receiver box.
Response of a SET to large rf interference signals
NASA Astrophysics Data System (ADS)
Lewis, Rupert; Harris, C. Thomas; Shaner, Eric
Single electron transistors (SETs) fabricated from aluminum thin films and Al/AlOx Josephson tunnel junctions can be added to other structures as charge sensors with large intrinsic bandwidth-for example, the charge sensing corral of an electrons on helium quantum chip. We characterized a SET at temperature T =40 mk for its ability to tolerate extraneous radio frequency (rf) interference in such applications at frequencies from 10 kHz to 50 MHz. Our SET, with charging energy, Ec 1 K, normal resistance Rn 600 k Ω, and peak measured charge sensitivity of Sp = 5 × 10-5electrons/ √Hz maintained usable sensitivity (S <1 × 10-3electrons/ √Hz) when subjected to rf signals of strength greater than +/- 9 electrons. This suggests for frequencies well below fc 1/2 πRnCj where Cj is the junction capacitance, that SETs respond nearly instantaneously even to large rf signals. Exploiting this knowledge, we were able to cancel a known rf signal at 1 MHz nearly recovering the charge sensitivity in the absence of rf signals-a result we expect will hold to higher frequencies. Work performed, in part, at the Center for Integrated Nanotechnologies, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Los Alamos National Laboratory (Contract DE-AC52-06NA25396) and Sandia National Laboratories (Contract DE-AC04-94AL85000). Sandia National Laboratories is a multi-mission laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.
Array signal recovery algorithm for a single-RF-channel DBF array
NASA Astrophysics Data System (ADS)
Zhang, Duo; Wu, Wen; Fang, Da Gang
2016-12-01
An array signal recovery algorithm based on sparse signal reconstruction theory is proposed for a single-RF-channel digital beamforming (DBF) array. A single-RF-channel antenna array is a low-cost antenna array in which signals are obtained from all antenna elements by only one microwave digital receiver. The spatially parallel array signals are converted into time-sequence signals, which are then sampled by the system. The proposed algorithm uses these time-sequence samples to recover the original parallel array signals by exploiting the second-order sparse structure of the array signals. Additionally, an optimization method based on the artificial bee colony (ABC) algorithm is proposed to improve the reconstruction performance. Using the proposed algorithm, the motion compensation problem for the single-RF-channel DBF array can be solved effectively, and the angle and Doppler information for the target can be simultaneously estimated. The effectiveness of the proposed algorithms is demonstrated by the results of numerical simulations.
FERMILAB CRYOMODULE TEST STAND RF INTERLOCK SYSTEM
DOE Office of Scientific and Technical Information (OSTI.GOV)
Petersen, Troy; Diamond, J. S.; McDowell, D.
2016-10-12
An interlock system has been designed for the Fermilab Cryo-module Test Stand (CMTS), a test bed for the cryo- modules to be used in the upcoming Linac Coherent Light Source 2 (LCLS-II) project at SLAC. The interlock system features 8 independent subsystems, one per superconducting RF cavity and solid state amplifier (SSA) pair. Each system monitors several devices to detect fault conditions such as arcing in the waveguides or quenching of the SRF system. Additionally each system can detect fault conditions by monitoring the RF power seen at the cavity coupler through a directional coupler. In the event of amore » fault condition, each system is capable of removing RF signal to the amplifier (via a fast RF switch) as well as turning off the SSA. Additionally, each input signal is available for re- mote viewing and recording via a Fermilab designed digitizer board and MVME 5500 processor.« less
Optical mixing of microwave signals in a nonlinear semiconductor laser amplifier modulator.
Capmany, José; Sales, Salvador; Pastor, Daniel; Ortega, Beatriz
2002-02-11
In this paper we propose and evaluate the optical mixing of RF signals by means of exploiting the nonlinearity of a SLA modulator. The results show the potential for devices with low conversion losses (and even gain) and polarization insensitivity and reduced insertion losses.
NASA Astrophysics Data System (ADS)
Kii, Toshiteru; Nakai, Yoko; Fukui, Toshio; Zen, Heishun; Kusukame, Kohichi; Okawachi, Norihito; Nakano, Masatsugu; Masuda, Kai; Ohgaki, Hideaki; Yoshikawa, Kiyoshi; Yamazaki, Tetsuo
2007-01-01
Energy degradation due to back-bombardment effect is quite serious to produce high-brightness electron beam with long macro-pulse with thermionic rf gun. To avoid the back-bombardment problem, a laser photo cathode is used at many FEL facilities, but usually it costs high and not easy to operate. Thus we have studied long pulse operation of the rf gun with thermionic cathode, which is inexpensive and easy to operate compared to the photocathode rf gun. In this work, to reduce the energy degradation, we controlled input rf power amplitude by controlling pulse forming network of the power modulator for klystron. We have successfully increased the pulse duration up to 4 μs by increasing the rf power from 7.8 MW to 8.5 MW during the macro pulse.
Single frequency RF powered ECG telemetry system
NASA Technical Reports Server (NTRS)
Ko, W. H.; Hynecek, J.; Homa, J.
1979-01-01
It has been demonstrated that a radio frequency magnetic field can be used to power implanted electronic circuitry for short range telemetry to replace batteries. A substantial reduction in implanted volume can be achieved by using only one RF tank circuit for receiving the RF power and transmitting the telemetered information. A single channel telemetry system of this type, using time sharing techniques, was developed and employed to transmit the ECG signal from Rhesus monkeys in primate chairs. The signal from the implant is received during the period when the RF powering radiation is interrupted. The ECG signal is carried by 20-microsec pulse position modulated pulses, referred to the trailing edge of the RF powering pulse. Satisfactory results have been obtained with this single frequency system. The concept and the design presented may be useful for short-range long-term implant telemetry systems.
Analog Techniques in CEBAF's RF Control System
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hovater, J.; Fugitt, Jock
1988-01-01
Recent developments in high-speed analog technology have progressed into the areas of traditional RF technology.Diode-related devices are being replaced by analog IC's in the CEBAF RF control system.Complex phase modulators and attenuators have been successfully tested at 70 MHz.They have three advantages over existing technology: lower cost, less temperature sensitivity, and more linearity.RF signal conditioning components and how to implement the new analog IC's will be covered in this paper.
Identification coding schemes for modulated reflectance systems
Coates, Don M [Santa Fe, NM; Briles, Scott D [Los Alamos, NM; Neagley, Daniel L [Albuquerque, NM; Platts, David [Santa Fe, NM; Clark, David D [Santa Fe, NM
2006-08-22
An identifying coding apparatus employing modulated reflectance technology involving a base station emitting a RF signal, with a tag, located remotely from the base station, and containing at least one antenna and predetermined other passive circuit components, receiving the RF signal and reflecting back to the base station a modulated signal indicative of characteristics related to the tag.
El-Desouki, Munir M; Qasim, Syed Manzoor; BenSaleh, Mohammed; Deen, M Jamal
2013-08-02
Ultra-low power radio frequency (RF) transceivers used in short-range application such as wireless sensor networks (WSNs) require efficient, reliable and fully integrated transmitter architectures with minimal building blocks. This paper presents the design, implementation and performance evaluation of single-chip, fully integrated 2.4 GHz and 433 MHz RF transmitters using direct-modulation power voltage-controlled oscillators (PVCOs) in addition to a 2.0 GHz phase-locked loop (PLL) based transmitter. All three RF transmitters have been fabricated in a standard mixed-signal CMOS 0.18 µm technology. Measurement results of the 2.4 GHz transmitter show an improvement in drain efficiency from 27% to 36%. The 2.4 GHz and 433 MHz transmitters deliver an output power of 8 dBm with a phase noise of -122 dBc/Hz at 1 MHz offset, while drawing 15.4 mA of current and an output power of 6.5 dBm with a phase noise of -120 dBc/Hz at 1 MHz offset, while drawing 20.8 mA of current from 1.5 V power supplies, respectively. The PLL transmitter delivers an output power of 9 mW with a locking range of 128 MHz and consumes 26 mA from 1.8 V power supply. The experimental results demonstrate that the RF transmitters can be efficiently used in low power WSN applications.
Phase stable RF transport system
Curtin, Michael T.; Natter, Eckard F.; Denney, Peter M.
1992-01-01
An RF transport system delivers a phase-stable RF signal to a load, such as an RF cavity of a charged particle accelerator. A circuit generates a calibration signal at an odd multiple frequency of the RF signal where the calibration signal is superimposed with the RF signal on a common cable that connects the RF signal with the load. Signal isolating diplexers are located at both the RF signal source end and load end of the common cable to enable the calibration to be inserted and extracted from the cable signals without any affect on the RF signal. Any phase shift in the calibration signal during traverse of the common cable is then functionally related to the phase shift in the RF signal. The calibration phase shift is used to control a phase shifter for the RF signal to maintain a stable RF signal at the load.
Method of phase space beam dilution utilizing bounded chaos generated by rf phase modulation
Pham, Alfonse N.; Lee, S. Y.; Ng, K. Y.
2015-12-10
This paper explores the physics of chaos in a localized phase-space region produced by rf phase modulation applied to a double rf system. The study can be exploited to produce rapid particle bunch broadening exhibiting longitudinal particle distribution uniformity. Hamiltonian models and particle-tracking simulations are introduced to understand the mechanism and applicability of controlled particle diffusion. When phase modulation is applied to the double rf system, regions of localized chaos are produced through the disruption and overlapping of parametric resonant islands and configured to be bounded by well-behaved invariant tori to prevent particle loss. The condition of chaoticity and themore » degree of particle dilution can be controlled by the rf parameters. As a result, the method has applications in alleviating adverse space-charge effects in high-intensity beams, particle bunch distribution uniformization, and industrial radiation-effects experiments.« less
Amplification of a bi-phase shift-key modulated signal by a mm-wave FEL
DOE Office of Scientific and Technical Information (OSTI.GOV)
Prosnitz, D.; Scharlemann, E.T.; Sheaffer, M.K.
Bi-phase shift keying (BPSK) is a modulation scheme used in communications and radar in which the phase of a transmitted rf signal is switched in a coded pattern between discrete values differing by {pi} radians. The transmitted information rate (in communications) or resolution (in imaging radar) depends on the rate at which the transmitted signal can be modulated. Modulation rates of greater than 1 GHz are generally desired. Although the instantaneous gain bandwidth of a mm-wave FEL amplifier can be much greater than 10 GHz, slippage may limit the BPSK modulation rate that can be amplified. Qualitative slippage arguments wouldmore » limit the modulation rate to relatively low values; nevertheless, simulations with a time-dependent FEL code (GINGER) indicate that rates of 2 GHz or more are amplified without much loss in modulation integrity. In this paper we describe the effects of slippage in the simulations and discuss the limits of simple arguments.« less
Estimation of Characteristics of Echo Envelope Using RF Echo Signal from the Liver
NASA Astrophysics Data System (ADS)
Yamaguchi, Tadashi; Hachiya, Hiroyuki; Kamiyama, Naohisa; Ikeda, Kazuki; Moriyasu, Norifumi
2001-05-01
To realize quantitative diagnosis of liver cirrhosis, we have been analyzing the probability density function (PDF) of echo amplitude using B-mode images. However, the B-mode image is affected by the various signal and image processing techniques used in the diagnosis equipment, so a detailed and quantitative analysis is very difficult. In this paper, we analyze the PDF of echo amplitude using RF echo signal and B-mode images of normal and cirrhotic livers, and compare both results to examine the validity of the RF echo signal.
Direct digital RF synthesis and modulation for MSAT mobile applications
NASA Technical Reports Server (NTRS)
Crozier, Stewart; Datta, Ravi; Sydor, John
1993-01-01
A practical method of performing direct digital RF synthesis using the Hilbert transform single sideband (SSB) technique is described. It is also shown that amplitude and phase modulation can be achieved directly at L-band with frequency stability and spurii performance exceeding stringent MSAT system requirements.
R.F Microphotonics for NASA Space Communications Applications
NASA Technical Reports Server (NTRS)
Pouch, John; Nguyen, Hung; Lee, Richard; Miranda, Felix; Hossein-Zadeh, Mani; Cohen, David; Levi, A. F. J.
2007-01-01
An RF microphotonic receiver has-been developed at Ka-band. The receiver consists of a lithium niobate micro-disk that enables RF-optical coupling to occur. The modulated optical signal (- 200 THz) is detected by the high-speed photonic signal processing electronics. When compared with an electronic approach, the microphotonic receiver technology offers 10 times smaller volume, smaller weight, and smaller power consumption; greater sensitivity; and optical isolation for use in extreme environments. The status of the technology development will be summarized, and the potential application of the receiver to NASA space communications systems will be described.
Acousto-optic RF signal acquisition system
NASA Astrophysics Data System (ADS)
Bloxham, Laurence H.
1990-09-01
This paper describes the architecture and performance of a prototype Acousto-Optic RF Signal Acquisition System designed to intercept, automatically identify, and track communication signals in the VHF band. The system covers 28.0 to 92.0 MHz with five manually selectable, dual conversion; 12.8 MHZ bandwidth front ends. An acousto-optic spectrum analyzer (AOSA) implemented using a tellurium dioxide (Te02) Bragg cell is used to channelize the 12.8 MHz pass band into 512 25 KHz channels. Polarization switching is used to suppress optical noise. Excellent isolation and dynamic range are achieved by using a linear array of 512 custom 40/50 micron fiber optic cables to collect the light at the focal plane of the AOSA and route the light to individual photodetectors. The photodetectors are operated in the photovoltaic mode to compress the greater than 60 dB input optical dynamic range into an easily processed electrical signal. The 512 signals are multiplexed and processed as a line in a video image by a customized digital image processing system. The image processor simultaneously analyzes the channelized signal data and produces a classical waterfall display.
NASA Astrophysics Data System (ADS)
Bito, Jo; Bahr, Ryan; Hester, Jimmy; Kimionis, John; Nauroze, Abdullah; Su, Wenjing; Tehrani, Bijan; Tentzeris, Manos M.
2017-05-01
In this paper, numerous inkjet-/3D-/4D-printed wearable flexible antennas, RF electronics, modules and sensors fabricated on paper and other polymer (e.g. LCP) substrates are introduced as a system-level solution for ultra-low-cost mass production of autonomous Biomonitoring, Positioning and Sensing applications. This paper briefly discusses the state-of-the-art area of fully-integrated wearable wireless sensor modules on paper or flexible LCP and show the first ever 4D sensor module integration on paper, as well as numerous 3D and 4D multilayer paper-based and LCP-based RF/microwave, flexible and wearable structures, that could potentially set the foundation for the truly convergent wireless sensor ad-hoc "on-body networks of the future with enhanced cognitive intelligence and "rugged" packaging. Also, some challenges concerning the power sources of "nearperpetual" wearable RF modules, including flexible miniaturized batteries as well as power-scavenging approaches involving electromagnetic and solar energy forms are discuessed. The final step of the paper will involve examples from mmW wearable (e.g. biomonitoring) antennas and RF modules, as well as the first examples of the integration of inkjet-printed nanotechnology-based (e.g.CNT) sensors on paper and organic substrates for Internet of Things (IoT) applications. It has to be noted that the paper will review and present challenges for inkjetprinted organic active and nonlinear devices as well as future directions in the area of environmentally-friendly "green") wearable RF electronics and "smart-skin conformal sensors.
RF transmission line and drill/pipe string switching technology for down-hole telemetry
Clark, David D [Santa Fe, NM; Coates, Don M [Santa Fe, NM
2007-08-14
A modulated reflectance well telemetry apparatus having an electrically conductive pipe extending from above a surface to a point below the surface inside a casing. An electrical conductor is located at a position a distance from the electrically conductive pipe and extending from above the surface to a point below the surface. Modulated reflectance apparatus is located below the surface for modulating well data into a RF carrier transmitted from the surface and reflecting the modulated carrier back to the surface. A RF transceiver is located at the surface and is connected between the electrically conductive pipe and the electrical conductor for transmitting a RF signal that is confined between the electrically conductive well pipe and the electrical conductor to the modulated reflectance apparatus, and for receiving reflected data on the well from the modulated reflectance apparatus.
Nonlinear optical modulation in a plasmonic Bi:YIG Mach-Zehnder interferometer
NASA Astrophysics Data System (ADS)
Firby, C. J.; Elezzabi, A. Y.
2017-02-01
In this work, we propose a magnetoplasmonic modulator for nonlinear radio-frequency (RF) modulation of an integrated optical signal. The modulator consists of a plasmonic Mach-Zehnder interferometer (MZI), constructed of the ferrimagnetic garnet, bismuth-substituted yttrium iron garnet (Bi:YIG). The transverse component of the Bi:YIG magnetization induces a nonreciprocal phase shift (NRPS) onto the guided optical mode, which can be actively modulated through external magnetic fields. In an MZI, the modulated phase shift in turn modulates the output optical intensity. Due to the highly nonlinear evolution of the Bi:YIG magnetization, we show that the spectrum of the output modulated intensity signal can contain harmonics of the driving RF field, frequency splitting around the driving frequency, down-conversion, or mixing of multiple RF signals. This device provides a unique mechanism of simultaneously generating a number of modulation frequencies within a single device.
Enhanced modulation rates via field modulation in spin torque nano-oscillators
DOE Office of Scientific and Technical Information (OSTI.GOV)
Purbawati, A.; Garcia-Sanchez, F.; Buda-Prejbeanu, L. D.
Spin Transfer Nano-Oscillators (STNOs) are promising candidates for telecommunications applications due to their frequency tuning capabilities via either a dc current or an applied field. This frequency tuning is of interest for Frequency Shift Keying concepts to be used in wireless communication schemes or in read head applications. For these technological applications, one important parameter is the characterization of the maximum achievable rate at which an STNO can respond to a modulating signal, such as current or field. Previous studies of in-plane magnetized STNOs on frequency modulation via an rf current revealed that the maximum achievable rate is limited bymore » the amplitude relaxation rate Γ{sub p}, which gives the time scale over which amplitude fluctuations are damped out. This might be a limitation for applications. Here, we demonstrate via numerical simulation that application of an additional rf field is an alternative way for modulation of the in-plane magnetized STNO configuration, which has the advantage that frequency modulation is not limited by the amplitude relaxation rate, so that higher modulation rates above GHz are achievable. This occurs when the modulating rf field is oriented along the easy axis (longitudinal rf field). Tilting the direction of the modulating rf field in-plane and perpendicularly with respect to the easy axis (transverse rf field), the modulation is again limited by the amplitude relaxation rate similar to the response observed in current modulation.« less
FPGA-based RF interference reduction techniques for simultaneous PET–MRI
Gebhardt, P; Wehner, J; Weissler, B; Botnar, R; Marsden, P K; Schulz, V
2016-01-01
Abstract The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) as a multi-modal imaging technique is considered very promising and powerful with regard to in vivo disease progression examination, therapy response monitoring and drug development. However, PET–MRI system design enabling simultaneous operation with unaffected intrinsic performance of both modalities is challenging. As one of the major issues, both the PET detectors and the MRI radio-frequency (RF) subsystem are exposed to electromagnetic (EM) interference, which may lead to PET and MRI signal-to-noise ratio (SNR) deteriorations. Early digitization of electronic PET signals within the MRI bore helps to preserve PET SNR, but occurs at the expense of increased amount of PET electronics inside the MRI and associated RF field emissions. This raises the likelihood of PET-related MRI interference by coupling into the MRI RF coil unwanted spurious signals considered as RF noise, as it degrades MRI SNR and results in MR image artefacts. RF shielding of PET detectors is a commonly used technique to reduce PET-related RF interferences, but can introduce eddy-current-related MRI disturbances and hinder the highest system integration. In this paper, we present RF interference reduction methods which rely on EM field coupling–decoupling principles of RF receive coils rather than suppressing emitted fields. By modifying clock frequencies and changing clock phase relations of digital circuits, the resulting RF field emission is optimised with regard to a lower field coupling into the MRI RF coil, thereby increasing the RF silence of PET detectors. Our methods are demonstrated by performing FPGA-based clock frequency and phase shifting of digital silicon photo-multipliers (dSiPMs) used in the PET modules of our MR-compatible Hyperion IID PET insert. We present simulations and magnetic-field map scans visualising the impact of altered clock phase pattern on the spatial RF field
FPGA-based RF interference reduction techniques for simultaneous PET-MRI.
Gebhardt, P; Wehner, J; Weissler, B; Botnar, R; Marsden, P K; Schulz, V
2016-05-07
The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) as a multi-modal imaging technique is considered very promising and powerful with regard to in vivo disease progression examination, therapy response monitoring and drug development. However, PET-MRI system design enabling simultaneous operation with unaffected intrinsic performance of both modalities is challenging. As one of the major issues, both the PET detectors and the MRI radio-frequency (RF) subsystem are exposed to electromagnetic (EM) interference, which may lead to PET and MRI signal-to-noise ratio (SNR) deteriorations. Early digitization of electronic PET signals within the MRI bore helps to preserve PET SNR, but occurs at the expense of increased amount of PET electronics inside the MRI and associated RF field emissions. This raises the likelihood of PET-related MRI interference by coupling into the MRI RF coil unwanted spurious signals considered as RF noise, as it degrades MRI SNR and results in MR image artefacts. RF shielding of PET detectors is a commonly used technique to reduce PET-related RF interferences, but can introduce eddy-current-related MRI disturbances and hinder the highest system integration. In this paper, we present RF interference reduction methods which rely on EM field coupling-decoupling principles of RF receive coils rather than suppressing emitted fields. By modifying clock frequencies and changing clock phase relations of digital circuits, the resulting RF field emission is optimised with regard to a lower field coupling into the MRI RF coil, thereby increasing the RF silence of PET detectors. Our methods are demonstrated by performing FPGA-based clock frequency and phase shifting of digital silicon photo-multipliers (dSiPMs) used in the PET modules of our MR-compatible Hyperion II (D) PET insert. We present simulations and magnetic-field map scans visualising the impact of altered clock phase pattern on the spatial RF field
FPGA-based RF interference reduction techniques for simultaneous PET-MRI
NASA Astrophysics Data System (ADS)
Gebhardt, P.; Wehner, J.; Weissler, B.; Botnar, R.; Marsden, P. K.; Schulz, V.
2016-05-01
The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) as a multi-modal imaging technique is considered very promising and powerful with regard to in vivo disease progression examination, therapy response monitoring and drug development. However, PET-MRI system design enabling simultaneous operation with unaffected intrinsic performance of both modalities is challenging. As one of the major issues, both the PET detectors and the MRI radio-frequency (RF) subsystem are exposed to electromagnetic (EM) interference, which may lead to PET and MRI signal-to-noise ratio (SNR) deteriorations. Early digitization of electronic PET signals within the MRI bore helps to preserve PET SNR, but occurs at the expense of increased amount of PET electronics inside the MRI and associated RF field emissions. This raises the likelihood of PET-related MRI interference by coupling into the MRI RF coil unwanted spurious signals considered as RF noise, as it degrades MRI SNR and results in MR image artefacts. RF shielding of PET detectors is a commonly used technique to reduce PET-related RF interferences, but can introduce eddy-current-related MRI disturbances and hinder the highest system integration. In this paper, we present RF interference reduction methods which rely on EM field coupling-decoupling principles of RF receive coils rather than suppressing emitted fields. By modifying clock frequencies and changing clock phase relations of digital circuits, the resulting RF field emission is optimised with regard to a lower field coupling into the MRI RF coil, thereby increasing the RF silence of PET detectors. Our methods are demonstrated by performing FPGA-based clock frequency and phase shifting of digital silicon photo-multipliers (dSiPMs) used in the PET modules of our MR-compatible Hyperion II D PET insert. We present simulations and magnetic-field map scans visualising the impact of altered clock phase pattern on the spatial RF field distribution
Airborne RF Measurement System (ARMS) and Analysis of Representative Flight RF Environment
NASA Technical Reports Server (NTRS)
Koppen, Sandra V.; Ely, Jay J.; Smith, Laura J.; Jones, Richard A.; Fleck, Vincent J.; Salud, Maria Theresa; Mielnik, John J.
2007-01-01
Environmental radio frequency (RF) data over a broad band of frequencies (30 MHz to 1000 MHz) were obtained to evaluate the electromagnetic environment in airspace around several airports. An RF signal measurement system was designed utilizing a spectrum analyzer connected to the NASA Lancair Columbia 300 aircraft's VHF/UHF navigation antenna. This paper presents an overview of the RF measurement system and provides analysis of sample RF signal measurement data. This aircraft installation package and measurement system can be quickly returned to service if needed by future projects requiring measurement of an RF signal environment or exploration of suspected interference situations.
NASA Astrophysics Data System (ADS)
Kondoh, Takafumi; Kashima, Hiroaki; Yang, Jinfeng; Yoshida, Yoichi; Tagawa, Seiichi
2008-10-01
In intensity-modulated radiation therapy (IMRT), the aim is to deliver reduced doses of radiation to normal tissue. As a step toward IMRT, we examined dynamic optical modulation of an electron beam produced by a photocathode RF gun. Images on photomasks were transferred onto a photocathode by relay imaging. The resulting beam was controlled by a remote mirror. The modulated electron beam maintained its shape on acceleration, had a fine spatial resolution, and could be moved dynamically by optical methods.
Airborne RF Measurement System and Analysis of Representative Flight RF Environment
NASA Technical Reports Server (NTRS)
Koppen, Sandra V.; Ely, Jay J.; Smith, Laura J.; Jones, Richard A.; Fleck, Vincent J.; Salud, Maria Theresa; Mielnik, John
2007-01-01
Environmental radio frequency (RF) data over a broad band of frequencies were needed to evaluate the airspace around several airports. An RF signal measurement system was designed using a spectrum analyzer connected to an aircraft VHF/UHF navigation antenna installed on a small aircraft. This paper presents an overview of the RF measurement system and provides analysis of a sample of RF signal measurement data over a frequency range of 30 MHz to 1000 MHz.
NASA Astrophysics Data System (ADS)
Zhu, Zihang; Zhao, Shanghong; Li, Xuan; Qu, Kun; Lin, Tao
2018-01-01
A photonic approach to generate frequency-doubled microwave waveforms using an integrated dual-polarization quadrature phase shift keying (DP-QPSK) modulator driven by a sinusoidal radio frequency (RF) signal is proposed. By adjusting the dc bias points of the DP-QPSK modulator, the obtained second-order and six-order harmonics are in phase while the fourth-order harmonics are complementary when the orthogonal polarized outputs of the modulator are photodetected. After properly setting the modulation indices of the modulator, the amplitude of the second-order harmonic is 9 times of that of the six-order harmonic, indicating a frequency-doubled triangular waveform is generated. If a broadband 90° microwave phase shifter is attached after the photodetector (PD) to introduce a 90° phase shift, a frequency-doubled square waveform can be obtained after adjusting the amplitude of the second-order harmonic 3 times of that of the six-order harmonic. The proposal is first theoretically analyzed and then validated by simulation. Simulation results show that a 10 GHz triangular and square waveform sequences are successfully generated from a 5 GHz sinusoidal RF drive signal.
Srivastava, Viranjay M
2015-01-01
In the present technological expansion, the radio frequency integrated circuits in the wireless communication technologies became useful because of the replacement of increasing number of functions, traditional hardware components by modern digital signal processing. The carrier frequencies used for communication systems, now a day, shifted toward the microwave regime. The signal processing for the multiple inputs multiple output wireless communication system using the Metal- Oxide-Semiconductor Field-Effect-Transistor (MOSFET) has been done a lot. In this research the signal processing with help of nano-scaled Cylindrical Surrounding Double Gate (CSDG) MOSFET by means of Double- Pole Four-Throw Radio-Frequency (DP4T RF) switch, in terms of Insertion loss, Isolation, Reverse isolation and Inter modulation have been analyzed. In addition to this a channel model has been presented. Here, we also discussed some patents relevant to the topic.
Barbaro, V; Bartolini, P; Calcagnini, G; Censi, F; Beard, B; Ruggera, P; Witters, D
2003-06-07
The aim of this study was to investigate the mechanisms by which the radiated radiofrequency (RF) GSM (global system for mobile communication) signal may affect pacemaker (PM) function. We measured the signal at the output of the sensing amplifier of PMs with various configurations of low-pass filters. We used three versions of the same PM model: one with a block capacitor which short circuits high-frequency signals; one with a ceramic feedthrough capacitor, a hermetically sealed mechanism connecting the internal electronics to the external connection block, and one with both. The PMs had been modified to have an electrical shielded connection to the output of the sensing amplifier. For each PM, the output of the sensing amplifier was monitored under exposure to modulated and non-modulated RF signals, and to GSM signals (900 and 1800 MHz). Non-modulated RF signals did not alter the response of the PM sensing amplifier. Modulated RF signals showed that the block capacitor did not succeed in short circuiting the RF signal, which is somehow demodulated by the PM internal non-linear circuit elements. Such a demodulation phenomenon poses a critical problem because digital cellular phones use extremely low-frequency modulation (as low as 2 Hz). which can be mistaken for normal heartbeat.
10 GHz dual loop opto-electronic oscillator without RF-amplifiers
NASA Astrophysics Data System (ADS)
Zhou, Weimin; Okusaga, Olukayode; Nelson, Craig; Howe, David; Carter, Gary
2008-02-01
We report the first demonstration of a 10 GHz dual-fiber-loop Opto-Electronic Oscillator (OEO) without RF-amplifiers. Using a recently developed highly efficient RF-Photonic link with RF-to-RF gain facilitated by a high power laser, highly efficient optical modulator and high power phototectectors, we have built an amplifier-less OEO that eliminates the phase noise produced by the electronic amplifier. The dual-loop approach can provide additional gain and reduce unwanted multi-mode spurs. However, we have observed RF phase noise produced by the high power laser include relative intensity noise (RIN) and noise related to the laser's electronic control system. In addition, stimulated Brillouin scattering limits the fiber loop's length to ~2km at the 40mW laser power needed to provide the RF gain which limits the system's quality factor, Q. We have investigated several different methods for solving these problems. One promising technique is the use of a multi-longitudinal-mode laser to carry the RF signal, maintaining the total optical power but reducing the optical power of each mode to eliminate the Brillouin scattering in a longer fiber thereby reducing the phase noise of the RF signal produced by the OEO. This work shows that improvement in photonic components increases the potential for more RF system applications such as an OEO's with higher performance and new capabilities.
RF/optical shared aperture for high availability wideband communication RF/FSO links
Ruggiero, Anthony J; Pao, Hsueh-yuan; Sargis, Paul
2014-04-29
An RF/Optical shared aperture is capable of transmitting and receiving optical signals and RF signals simultaneously. This technology enables compact wide bandwidth communications systems with 100% availability in clear air turbulence, rain and fog. The functions of an optical telescope and an RF reflector antenna are combined into a single compact package by installing an RF feed at either of the focal points of a modified Gregorian telescope.
RF/optical shared aperture for high availability wideband communication RF/FSO links
Ruggiero, Anthony J; Pao, Hsueh-yuan; Sargis, Paul
2015-03-24
An RF/Optical shared aperture is capable of transmitting and receiving optical signals and RF signals simultaneously. This technology enables compact wide bandwidth communications systems with 100% availability in clear air turbulence, rain and fog. The functions of an optical telescope and an RF reflector antenna are combined into a single compact package by installing an RF feed at either of the focal points of a modified Gregorian telescope.
Design and Development of Amplitude and phase measurement of RF signal with Digital I-Q Demodulator
NASA Astrophysics Data System (ADS)
Soni, Dipal; Rajnish, Kumar; Verma, Sriprakash; Patel, Hriday; Trivedi, Rajesh; Mukherjee, Aparajita
2017-04-01
ITER-India, working as a nodal agency from India for ITER project [1], is responsible to deliver one of the packages, called Ion Cyclotron Heating & Current Drive (ICH&CD) - Radio Frequency Power Sources (RFPS). RFPS is having two cascaded amplifier chains (10 kW, 130 kW & 1.5 MW) combined to get 2.5 MW RF power output. Directional couplers are inserted at the output of each stage to extract forward power and reflected power as samples for measurement of amplitude and phase. Using passive mixer, forward power and reflected power are down converted to 1MHz Intermediate frequency (IF). This IF signal is used as an input to the Digital IQ Demodulator (DIQDM). DIQDM is realized using National Instruments make PXI hardware & LabVIEW software tool. In this paper, Amplitude and Phase measurement of RF signal with DIQDM technique is described. Also test results with dummy signals and signal generated from low power RF systems is discussed here.
Synchronous radio-frequency FM signal generator using direct digital synthesizers
NASA Astrophysics Data System (ADS)
Arablu, Masoud; Kafashi, Sajad; Smith, Stuart T.
2018-04-01
A novel Radio-Frequency Frequency-Modulated (RF-FM) signal generation method is introduced and a prototype circuit developed to evaluate its functionality and performance. The RF-FM signal generator uses a modulated, voltage-controlled time delay to correspondingly modulate the phase of a 10 MHz sinusoidal reference signal. This modulated reference signal is, in turn, used to clock a Direct Digital Synthesizer (DDS) circuit resulting in an FM signal at its output. The modulating signal that is input to the voltage-controlled time delay circuit is generated by another DDS that is synchronously clocked by the same 10 MHz sine wave signal before modulation. As a consequence, all of the digital components are timed from a single sine wave oscillator that forms the basis of all timing. The resultant output signal comprises a center, or carrier, frequency plus a series of phase-synchronized sidebands having exact integer harmonic frequency separation. In this study, carrier frequencies ranging from 10 MHz to 70 MHz are generated with modulation frequencies ranging from 10 kHz to 300 kHz. The captured spectra show that the FM signal characteristics, amplitude and phase, of the sidebands and the modulation depth are consistent with the Jacobi-Anger expansion for modulated harmonic signals.
Cytostatic response of NB69 cells to weak pulse-modulated 2.2 GHz radar-like signals.
Trillo, María A; Cid, María Antonia; Martínez, Maria Antonia; Page, Juan E; Esteban, Jaime; Úbeda, Alejandro
2011-07-01
The present study investigates the response of two human cancer cell lines to a 24-h treatment with a 2.2-GHz, pulse-modulated (5 µs pulse duration, 100 Hz repetition rate) radar-like signal at an average SAR = 0.023 W/kg, using a newly designed setup for in vitro exposure to radiofrequency (RF) fields. A complete discretized model of the setup was created for numerical dosimetry using finite-difference time-domain (FDTD) software, SEMCAD X. The average dose of RF radiation absorbed by the cultures was calculated to be subthermal (ΔT < 0.1 °C). The RF exposure induced a consistent, statistically significant reduction in the cell number (13.5% below controls, P < 0.001) in the neuroblastoma NB69 line. This effect was accompanied with slight but statistically significant increases in the proportions of cells in phases G0/G1 and G2/M of the cell cycle (6% and 9%, respectively; P < 0.05 over controls). By contrast, the hepatocarcinoma cell line HepG2 did not respond to the same RF treatment. These results indicate that a pulse-modulated RF radiation with high instantaneous amplitude and low average power can induce cytostatic responses on specific, sensitive cancer cell lines. The effect would be mediated, at least in part, by alterations in the kinetics of the cell cycle. Copyright © 2011 Wiley-Liss, Inc.
III-V on silicon micro-photonic circuits for frequency downconversion of RF signals
NASA Astrophysics Data System (ADS)
Roelkens, G.; Keyvaninia, S.; Tassaert, M.; Latkowski, S.; Bente, E.; Mariën, J.; Thomassen, L.; Baets, R.
2017-11-01
RF frequency downconverters are of key importance in communication satellites. Classically, this is implemented using an electronic mixer. In this paper we explore the use of photonic technology to realize the same functionality. The potential advantages of such an approach compared to the classical microwave solutions are that it is lighter weight, has lower power consumption and can be made smaller if photonic technology is used. An additional advantage is the fact that the optical local oscillator (LO) reference can easily be transported over longer distances than the equivalent LO signal in the microwave domain due to the large bandwidth and low loss and dispersion of optical fiber. Another big advantage is that one can envision the use of short pulse trains as the LO - starting off from a sinusoidal RF reference - in order to exploit subsampling. Subsampling avoids the need for high frequency LO references, which is especially valuable if a downconversion over several 10s of GHz is required. In this paper we present the operation principle of such a photonic frequency downconverter and describe the performance of the developed micro-photonic building blocks required for this functionality. These micro-photonic building blocks are implemented on a III-V semiconductor-on-silicon photonic platform. The components include a micro-photonic hybridly modelocked laser, a 30GHz electroabsorption modulator and an intermediate frequency (1.5GHz) photodetector.
Injection-locking of terahertz quantum cascade lasers up to 35GHz using RF amplitude modulation.
Gellie, Pierre; Barbieri, Stefano; Lampin, Jean-François; Filloux, Pascal; Manquest, Christophe; Sirtori, Carlo; Sagnes, Isabelle; Khanna, Suraj P; Linfield, Edmund H; Davies, A Giles; Beere, Harvey; Ritchie, David
2010-09-27
We demonstrate that the cavity resonance frequency - the round-trip frequency - of Terahertz quantum cascade lasers can be injection-locked by direct modulation of the bias current using an RF source. Metal-metal and single-plasmon waveguide devices with roundtrip frequencies up to 35GHz have been studied, and show locking ranges above 200MHz. Inside this locking range the laser round-trip frequency is phase-locked, with a phase noise determined by the RF-synthesizer. We find a square-root dependence of the locking range with RF-power in agreement with classical injection-locking theory. These results are discussed in the context of mode-locking operation.
Hinakura, Yosuke; Terada, Yosuke; Arai, Hiroyuki; Baba, Toshihiko
2018-04-30
We demonstrate a Si photonic crystal waveguide Mach-Zehnder modulator that incorporates meander-line electrodes to compensate for the phase mismatch between slow light and RF signals. We first employed commonized ground electrodes in the modulator to suppress undesired fluctuations in the electro-optic (EO) response due to coupled slot-line modes of RF signals. Then, we theoretically and experimentally investigated the effect of the phase mismatch on the EO response. We confirmed that meander-line electrodes improve the EO response, particularly in the absence of internal reflection of the RF signals. The cut-off frequency of this device can reach 27 GHz, which allows high-speed modulation up to 50 Gbps.
System for Automated Calibration of Vector Modulators
NASA Technical Reports Server (NTRS)
Lux, James; Boas, Amy; Li, Samuel
2009-01-01
Vector modulators are used to impose baseband modulation on RF signals, but non-ideal behavior limits the overall performance. The non-ideal behavior of the vector modulator is compensated using data collected with the use of an automated test system driven by a LabVIEW program that systematically applies thousands of control-signal values to the device under test and collects RF measurement data. The technology innovation automates several steps in the process. First, an automated test system, using computer controlled digital-to-analog converters (DACs) and a computer-controlled vector network analyzer (VNA) systematically can apply different I and Q signals (which represent the complex number by which the RF signal is multiplied) to the vector modulator under test (VMUT), while measuring the RF performance specifically, gain and phase. The automated test system uses the LabVIEW software to control the test equipment, collect the data, and write it to a file. The input to the Lab - VIEW program is either user-input for systematic variation, or is provided in a file containing specific test values that should be fed to the VMUT. The output file contains both the control signals and the measured data. The second step is to post-process the file to determine the correction functions as needed. The result of the entire process is a tabular representation, which allows translation of a desired I/Q value to the required analog control signals to produce a particular RF behavior. In some applications, corrected performance is needed only for a limited range. If the vector modulator is being used as a phase shifter, there is only a need to correct I and Q values that represent points on a circle, not the entire plane. This innovation has been used to calibrate 2-GHz MMIC (monolithic microwave integrated circuit) vector modulators in the High EIRP Cluster Array project (EIRP is high effective isotropic radiated power). These calibrations were then used to create
NASA Astrophysics Data System (ADS)
Kaba, M.; Zhou, F. C.; Lim, A.; Decoster, D.; Huignard, J.-P.; Tonda, S.; Dolfi, D.; Chazelas, J.
2007-11-01
The applications of microwave optoelectronics are extremely large since they extend from the Radio-over-Fibre to the Homeland security and defence systems. Then, the improved maturity of the optoelectronic components operating up to 40GHz permit to consider new optical processing functions (filtering, beamforming, ...) which can operate over very wideband microwave analogue signals. Specific performances are required which imply optical delay lines able to exhibit large Time-Bandwidth product values. It is proposed to evaluate slow light approach through highly dispersive structures based on either uniform or chirped Bragg Gratings. Therefore, we highlight the impact of the major parameters of such structures: index modulation depth, grating length, grating period, chirp coefficient and demonstrate the high potentiality of Bragg Grating for Large RF signals bandwidth processing under slow-light propagation.
Real-time digital signal processing for live electro-optic imaging.
Sasagawa, Kiyotaka; Kanno, Atsushi; Tsuchiya, Masahiro
2009-08-31
We present an imaging system that enables real-time magnitude and phase detection of modulated signals and its application to a Live Electro-optic Imaging (LEI) system, which realizes instantaneous visualization of RF electric fields. The real-time acquisition of magnitude and phase images of a modulated optical signal at 5 kHz is demonstrated by imaging with a Si-based high-speed CMOS image sensor and real-time signal processing with a digital signal processor. In the LEI system, RF electric fields are probed with light via an electro-optic crystal plate and downconverted to an intermediate frequency by parallel optical heterodyning, which can be detected with the image sensor. The artifacts caused by the optics and the image sensor characteristics are corrected by image processing. As examples, we demonstrate real-time visualization of electric fields from RF circuits.
Capmany, José; Pastor, Daniel; Martinez, Alfonso; Ortega, Beatriz; Sales, Salvador
2003-08-15
We report on a novel technical approach to the implementation of photonic rf filters that is based on the pi phase inversion that a rf modulating signal suffers in an electro-optic Mach-Zehnder modulator, which depends on whether the positive or the negative linear slope of the signal's modulation transfer function is employed. Experimental evidence is provided of the implementation of filters with negative coefficients that shows excellent agreement with results predicted by the theory.
Spectral Domain RF Fingerprinting for 802.11 Wireless Devices
2010-03-01
induce unintentional modulation effects . If these effects (features) are sufficiently unique, it becomes possible to identify a device us- ing its...Previous AFIT research has demonstrated the effectiveness of RF Fin- gerprinting using 802.11A signals with 1) spectral correlation on Power Spectral...32 4.5. SD Intra-manufacturer Classification: Effects of Burst Location Error
Analysis of a digital RF memory in a signal-delay application
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jelinek, D.A.
1992-03-01
Laboratory simulation of the approach of a radar fuze towards a target is an important factor in our ability to accurately measure the radar`s performance. This simulation is achieved, in part, by dynamically delaying and attenuating the radar`s transmitted pulse and sending the result back to the radar`s receiver. Historically, the device used to perform the dynamic delay has been a limiting factor in the evaluation of a radar`s performance and characteristics. A new device has been proposed that appears to have more capability than previous dynamic delay devices. This device is the digital RF memory. This report presents themore » results of an analysis of a digital RF memory used in a signal-delay application. 2 refs.« less
Analysis of a digital RF memory in a signal-delay application
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jelinek, D.A.
1992-03-01
Laboratory simulation of the approach of a radar fuze towards a target is an important factor in our ability to accurately measure the radar's performance. This simulation is achieved, in part, by dynamically delaying and attenuating the radar's transmitted pulse and sending the result back to the radar's receiver. Historically, the device used to perform the dynamic delay has been a limiting factor in the evaluation of a radar's performance and characteristics. A new device has been proposed that appears to have more capability than previous dynamic delay devices. This device is the digital RF memory. This report presents themore » results of an analysis of a digital RF memory used in a signal-delay application. 2 refs.« less
An analog RF gap voltage regulation system for the Advanced Photon Source storage ring.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Horan, D.
1999-04-13
An analog rf gap voltage regulation system has been designed and built at Argonne National Laboratory to maintain constant total storage ring rf gap voltage, independent of beam loading and cavity tuning effects. The design uses feedback control of the klystron mod-anode voltage to vary the amount of rf power fed to the storage ring cavities. The system consists of two independent feedback loops, each regulating the combined rf gap voltages of eight storage ring cavities by varying the output power of either one or two rf stations, depending on the mode of operation. It provides full operator control andmore » permissive logic to permit feedback control of the rf system output power only if proper conditions are met. The feedback system uses envelope-detected cavity field probe outputs as the feedback signal. Two different methods of combining the individual field probe signals were used to generate a relative DC level representing one-half of the total storage ring rf voltage, an envelope-detected vector sum of the field probe rf signals, and the DC sum of individual field probe envelope detector outputs. The merits of both methods are discussed. The klystron high-voltage power supply (HVPS) units are fitted with an analog interface for external control of the mod-anode voltage level, using a four-quadrant analog multiplier to modulate the HVPS mod-anode voltage regulator set-point in response to feedback system commands.« less
Ultra-wideband microwave photonic link based on single-sideband modulation
NASA Astrophysics Data System (ADS)
Li, Jingnan; Wang, Yunxin; Wang, Dayong; Zhou, Tao; Zhong, Xin; Xu, Jiahao; Yang, Dengcai; Rong, Lu
2017-10-01
Comparing with the conventional double-sideband (DSB) modulation in communication system, single-sideband (SSB) modulation only demands half bandwidth of DSB in transmission. Two common ways are employed to implement SSB modulation by using optical filter (OF) or electrical 90° phase shift, respectively. However, the bandwidth of above methods is limited by characteristics of current OF and electrical phase shift. To overcome this problem, an ultra-wideband microwave photonic link based on SSB modulation is proposed and demonstrated. The radio frequency (RF) signal modulates a single-drive dual-parallel Mach-Zehnder modulator, and the SSB modulation is realized by combining an electrical 90° hybrid coupler and an optical bandpass filter. The experimental results indicate that the system can achieve SSB modulation for RF signal from 2 to 40 GHz. The proposed microwave photonic link provides an ultra-wideband approach based on SSB modulation for radio-over-fiber system.
A simple 5-DoF MR-compatible motion signal measurement system.
Chung, Soon-Cheol; Kim, Hyung-Sik; Yang, Jae-Woong; Lee, Su-Jeong; Choi, Mi-Hyun; Kim, Ji-Hye; Yeon, Hong-Won; Park, Jang-Yeon; Yi, Jeong-Han; Tack, Gye-Rae
2011-09-01
The purpose of this study was to develop a simple motion measurement system with magnetic resonance (MR) compatibility and safety. The motion measurement system proposed here can measure 5-DoF motion signals without deteriorating the MR images, and it has no effect on the intense and homogeneous main magnetic field, the temporal-gradient magnetic field (which varies rapidly with time), the transceiver radio frequency (RF) coil, and the RF pulse during MR data acquisition. A three-axis accelerometer and a two-axis gyroscope were used to measure 5-DoF motion signals, and Velcro was used to attach a sensor module to a finger or wrist. To minimize the interference between the MR imaging system and the motion measurement system, nonmagnetic materials were used for all electric circuit components in an MR shield room. To remove the effect of RF pulse, an amplifier, modulation circuit, and power supply were located in a shielded case, which was made of copper and aluminum. The motion signal was modulated to an optic signal using pulse width modulation, and the modulated optic signal was transmitted outside the MR shield room using a high-intensity light-emitting diode and an optic cable. The motion signal was recorded on a PC by demodulating the transmitted optic signal into an electric signal. Various kinematic variables, such as angle, acceleration, velocity, and jerk, can be measured or calculated by using the motion measurement system developed here. This system also enables motion tracking by extracting the position information from the motion signals. It was verified that MR images and motion signals could reliably be measured simultaneously.
Error compensation of IQ modulator using two-dimensional DFT
NASA Astrophysics Data System (ADS)
Ohshima, Takashi; Maesaka, Hirokazu; Matsubara, Shinichi; Otake, Yuji
2016-06-01
It is important to precisely set and keep the phase and amplitude of an rf signal in the accelerating cavity of modern accelerators, such as an X-ray Free Electron Laser (XFEL) linac. In these accelerators an acceleration rf signal is generated or detected by an In-phase and Quadrature (IQ) modulator, or a demodulator. If there are any deviations of the phase and the amplitude from the ideal values, crosstalk between the phase and the amplitude of the output signal of the IQ modulator or the demodulator arises. This causes instability of the feedback controls that simultaneously stabilize both the rf phase and the amplitude. To compensate for such deviations, we developed a novel compensation method using a two-dimensional Discrete Fourier Transform (DFT). Because the observed deviations of the phase and amplitude of an IQ modulator involve sinusoidal and polynomial behaviors on the phase angle and the amplitude of the rf vector, respectively, the DFT calculation with these basis functions makes a good approximation with a small number of compensation coefficients. Also, we can suppress high-frequency noise components arising when we measure the deviation data. These characteristics have advantages compared to a Look Up Table (LUT) compensation method. The LUT method usually demands many compensation elements, such as about 300, that are not easy to treat. We applied the DFT compensation method to the output rf signal of a C-band IQ modulator at SACLA, which is an XFEL facility in Japan. The amplitude deviation of the IQ modulator after the DFT compensation was reduced from 15.0% at the peak to less than 0.2% at the peak for an amplitude control range of from 0.1 V to 0.9 V (1.0 V full scale) and for a phase control range from 0 degree to 360 degrees. The number of compensation coefficients is 60, which is smaller than that of the LUT method, and is easy to treat and maintain.
The report describes in a historical context the experiments that have been performed to examine the biological responses caused by exposure to low frequency electromagnetic radiation directly or as modulation of RF carrier waves. A detailed review is provided of the independentl...
RF Bearing Estimation in Wireless Sensor Networks
2010-01-01
are the main design drivers. Techniques based on ultrasonic and infrared signal modalities have short range and require line-of-sight. Clearly, RF...generating a Doppler shifted RF signal . The small frequency change can be measured even on low cost resource constrained nodes using a radio...is already included in the power budget and RF range is superior to most other signals . Radio signal strength (RSS) based approaches are the most
Learning and Visualizing Modulation Discriminative Radio Signal Features
2016-09-01
implemented as a mapping of a sequence of in-phase quadrature ( IQ ) measurements generated by a software-defined radio to a probability distri- bution...over modulation classes. 3.1 TRAINING SNR EVALUATION Training CNNs on RF data raises the unique question of determining an optimal training SNR, that
Zhang, Fangzheng; Pan, Shilong
2013-11-04
A novel scheme for photonic generation of a millimeter-wave ultra-wideband (MMW-UWB) signal is proposed and experimentally demonstrated based on a dual-parallel Mach-Zehnder modulator (DPMZM). In the proposed scheme, a single-frequency radio frequency (RF) signal is applied to one sub-MZM of the DPMZM to achieve optical suppressed-carrier modulation, and an electrical control pulse train is applied to the other sub-MZM biased at the minimum transmission point, to get an on/off switchable optical carrier. By filtering out the optical carrier with one of the first-order sidebands, and properly setting the amplitude of the control pulse, an MMW-UWB pulse train without the residual local oscillation is generated after photo-detection. The generated MMW-UWB signal is background-free, because the low-frequency components in the electrical spectrum are effectively suppressed. In the experiment, an MMW-UWB pulse train centered at 25 GHz with a 10-dB bandwidth of 5.5 GHz is successfully generated. The low frequency components are suppressed by 22 dB.
Measurement Techniques for Transmit Source Clock Jitter for Weak Serial RF Links
NASA Technical Reports Server (NTRS)
Lansdowne, Chatwin A.; Schlesinger, Adam M.
2010-01-01
Techniques for filtering clock jitter measurements are developed, in the context of controlling data modulation jitter on an RF carrier to accommodate low signal-to-noise ratio thresholds of high-performance error correction codes. Measurement artifacts from sampling are considered, and a tutorial on interpretation of direct readings is included.
Zhang, Jinjin; Idiyatullin, Djaudat; Corum, Curtis A.; Kobayashi, Naoharu; Garwood, Michael
2017-01-01
Purpose Methods designed to image fast-relaxing spins, such as sweep imaging with Fourier transformation (SWIFT), often utilize high excitation bandwidth and duty cycle, and in some applications the optimal flip angle cannot be used without exceeding safe specific absorption rate (SAR) levels. The aim is to reduce SAR and increase the flexibility of SWIFT by applying time-varying gradient-modulation (GM). The modified sequence is called GM-SWIFT. Theory and Methods The method known as gradient-modulated offset independent adiabaticity was used to modulate the radiofrequency (RF) pulse and gradients. An expanded correlation algorithm was developed for GM-SWIFT to correct the phase and scale effects. Simulations and phantom and in vivo human experiments were performed to verify the correlation algorithm and to evaluate imaging performance. Results GM-SWIFT reduces SAR, RF amplitude, and acquisition time by up to 90%, 70%, and 45%, respectively, while maintaining image quality. The choice of GM parameter influences the lower limit of short T2* sensitivity, which can be exploited to suppress unwanted image haze from unresolvable ultrashort T2* signals originating from plastic materials in the coil housing and fixatives. Conclusions GM-SWIFT reduces peak and total RF power requirements and provides additional flexibility for optimizing SAR, RF amplitude, scan time, and image quality. PMID:25800547
A direct modulated optical link for MRI RF receive coil interconnection.
Yuan, Jing; Wei, Juan; Shen, G X
2007-11-01
Optical glass fiber is a promising alternative to traditional coaxial cables for MRI RF receive coil interconnection to avoid any crosstalk and electromagnetic interference between multiple channels. A direct modulated optical link is proposed for MRI coil interconnection in this paper. The link performances of power gain, frequency response and dynamic range are measured. Phantom and in vivo human head images have been demonstrated by the connection of this direct modulated optical link to a head coil on a 0.3T MRI scanner for the first time. Comparable image qualities to coaxial cable link verify the feasibility of using the optical link for imaging with minor modification on the existing scanners. This optical link could also be easily extended for multi-channel array interconnections at high field of 1.5 T.
Low-voltage differentially-signaled modulators.
Zortman, William A; Lentine, Anthony L; Trotter, Douglas C; Watts, Michael R
2011-12-19
For exascale computing applications, viable optical solutions will need to operate using low voltage signaling and with low power consumption. In this work, the first differentially signaled silicon resonator is demonstrated which can provide a 5dB extinction ratio using 3fJ/bit and 500mV signal amplitude at 10Gbps. Modulation with asymmetric voltage amplitudes as low as 150mV with 3dB extinction are demonstrated at 10Gbps as well. Differentially signaled resonators simplify and expand the design space for modulator implementation and require no special drivers.
NASA Astrophysics Data System (ADS)
Reza, Syed Azer
This dissertation proposes the use of the emerging Micro-Electro-Mechanical Systems (MEMS) and agile lensing optical device technologies to design novel and powerful signal conditioning and sensing modules for advanced applications in optical communications, physical parameter sensing and RF/optical signal processing. For example, these new module designs have experimentally demonstrated exceptional features such as stable loss broadband operations and high > 60 dB optical dynamic range signal filtering capabilities. The first part of the dissertation describes the design and demonstration of digital MEMS-based signal processing modules for communication systems and sensor networks using the TI DLP (Digital Light Processing) technology. Examples of such modules include optical power splitters, narrowband and broadband variable fiber optical attenuators, spectral shapers and filters. Compared to prior works, these all-digital designs have advantages of repeatability, accuracy, and reliability that are essential for advanced communications and sensor applications. The next part of the dissertation proposes, analyzes and demonstrates the use of analog opto-fluidic agile lensing technology for sensor networks and test and measurement systems. Novel optical module designs for distance sensing, liquid level sensing, three-dimensional object shape sensing and variable photonic delay lines are presented and experimentally demonstrated. Compared to prior art module designs, the proposed analog-mode modules have exceptional performances, particularly for extreme environments (e.g., caustic liquids) where the free-space agile beam-based sensor provide remote non-contact access for physical sensing operations. The dissertation also presents novel modules involving hybrid analog-digital photonic designs that make use of the different optical device technologies to deliver the best features of both analog and digital optical device operations and controls. Digital controls are
DOE Office of Scientific and Technical Information (OSTI.GOV)
Balcazar, Mario D.; Yonehara, Katsuya; Moretti, Alfred
Intense neutrino beam is a unique probe for researching beyond the standard model. Fermilab is the main institution to produce the most powerful and widespectrum neutrino beam. From that respective, a radiation robust beam diagnostic system is a critical element in order to maintain the quality of the neutrino beam. Within this context, a novel radiation-resistive beam profile monitor based on a gasfilled RF cavity is proposed. The goal of this measurement is to study a tunable Qfactor RF cavity to determine the accuracy of the RF signal as a function of the quality factor. Specifically, measurement error of themore » Q-factor in the RF calibration is investigated. Then, the RF system will be improved to minimize signal error.« less
NASA Astrophysics Data System (ADS)
Hisatake, Shintaro; Yamaguchi, Koki; Uchida, Hirohisa; Tojyo, Makoto; Oikawa, Yoichi; Miyaji, Kunio; Nagatsuma, Tadao
2018-04-01
We propose a new asynchronous measurement system to visualize the amplitude and phase distribution of a frequency-modulated electromagnetic wave. The system consists of three parts: a nonpolarimetric electro-optic frequency down-conversion part, a phase-noise-canceling part, and a frequency-tracking part. The photonic local oscillator signal generated by electro-optic phase modulation is controlled to track the frequency of the radio frequency (RF) signal to significantly enhance the measurable RF bandwidth. We demonstrate amplitude and phase measurement of a quasi-millimeter-wave frequency-modulated continuous-wave signal (24 GHz ± 80 MHz with a 2.5 ms period) as a proof-of-concept experiment.
A transceiver module of the Mu radar
NASA Technical Reports Server (NTRS)
Kato, S.; Ogawa, T.; Tsuda, T.; Sato, T.; Kimura, I.; Fukao, S.
1983-01-01
The transceiver (TR) module of a middle and upper atmospheric radar is described. The TR module used in the radar is mainly composed of two units: a mixer (MIX unit) and a power amplifier (PA unit). The former generates the RF wave for transmission and converts the received echo to the IF signal. A 41.5-MHz local signal fed to mixers passes through a digitally controlled 8-bit phase shifter which can change its value up to 1,000 times in a second, so that the MU radar has the ability to steer its antenna direction quickly and flexibly. The MIX unit also contains a buffer amplifier and a gate for the transmitting signal and preamplifier for the received one whose noise figure is less than 5 dB. The PA unit amplifies the RF signal supplied from the MIX unit up to 63.7 dBm (2350 W), and feeds it to the crossed Yagi antenna.
Hybrid Modeling of SiH4/Ar Discharge in a Pulse Modulated RF Capacitively Coupled Plasma
NASA Astrophysics Data System (ADS)
Xi-Feng, Wang; Yuan-Hong, Song; You-Nian, Wang; PSEG Team
2015-09-01
Pulsed plasmas have offered important advantages in future micro-devices, especially for electronegative gas plasmas. In this work, a one-dimensional fluid and Monte-Carlo (MC) hybrid model is developed to simulate SiH4/Ar discharge in a pulse modulated radio-frequency (RF) capacitively coupled plasma (CCP). Time evolution densities of different species, such as electrons, ions, radicals, are calculated, as well as the electron energy probability function (EEPF) which is obtained by a MC simulation. By pulsing the RF source, the electron energy distributions and plasma properties can be modulated by pulse frequency and duty cycle. High electron energy tails are obtained during power-on period, with the SiHx densities increasing rapidly mainly by SiH4 dissociation. As the RF power is off, the densities in the bulk region decrease rapidly owing to high energy electrons disappear, but increase near electrodes since diffusion without the confinement of high electric field, which can prolong the time of radials deposition on the plate. Especially, in the afterglow, the increase of negative ions near the electrodes results from cool electron attachment, which are good for film deposition. This work was supported by the National Natural Science Foundation of China (Grant No. 11275038).
Analysis of signal to noise enhancement using a highly selective modulation tracking filter
NASA Technical Reports Server (NTRS)
Haden, C. R.; Alworth, C. W.
1972-01-01
Experiments are reported which utilize photodielectric effects in semiconductor loaded superconducting resonant circuits for suppressing noise in RF communication systems. The superconducting tunable cavity acts as a narrow band tracking filter for detecting conventional RF signals. Analytical techniques were developed which lead to prediction of signal-to-noise improvements. Progress is reported in optimization of the experimental variables. These include improved Q, new semiconductors, improved optics, and simplification of the electronics. Information bearing signals were passed through the system, and noise was introduced into the computer model.
Amplitude Modulations of Acoustic Communication Signals
NASA Astrophysics Data System (ADS)
Turesson, Hjalmar K.
2011-12-01
In human speech, amplitude modulations at 3 -- 8 Hz are important for discrimination and detection. Two different neurophysiological theories have been proposed to explain this effect. The first theory proposes that, as a consequence of neocortical synaptic dynamics, signals that are amplitude modulated at 3 -- 8 Hz are propagated better than un-modulated signals, or signals modulated above 8 Hz. This suggests that neural activity elicited by vocalizations modulated at 3 -- 8 Hz is optimally transmitted, and the vocalizations better discriminated and detected. The second theory proposes that 3 -- 8 Hz amplitude modulations interact with spontaneous neocortical oscillations. Specifically, vocalizations modulated at 3 -- 8 Hz entrain local populations of neurons, which in turn, modulate the amplitude of high frequency gamma oscillations. This suggests that vocalizations modulated at 3 -- 8 Hz should induce stronger cross-frequency coupling. Similar to human speech, we found that macaque monkey vocalizations also are amplitude modulated between 3 and 8 Hz. Humans and macaque monkeys share similarities in vocal production, implying that the auditory systems subserving perception of acoustic communication signals also share similarities. Based on the similarities between human speech and macaque monkey vocalizations, we addressed how amplitude modulated vocalizations are processed in the auditory cortex of macaque monkeys, and what behavioral relevance modulations may have. Recording single neuron activity, as well as, the activity of local populations of neurons allowed us to test both of the neurophysiological theories presented above. We found that single neuron responses to vocalizations amplitude modulated at 3 -- 8 Hz resulted in better stimulus discrimination than vocalizations lacking 3 -- 8 Hz modulations, and that the effect most likely was mediated by synaptic dynamics. In contrast, we failed to find support for the oscillation-based model proposing a
NASA Astrophysics Data System (ADS)
Aketagawa, Masato; Kimura, Shohei; Yashiki, Takuya; Iwata, Hiroshi; Banh, Tuan Quoc; Hirata, Kenji
2011-02-01
In this paper, we discuss a method to measure the free spectral range (FSR) of a Fabry-Perot cavity (FP-cavity) using frequency modulation with one electric optical modulator (EOM) and the null method. A laser beam modulated by the EOM, to which a sine wave signal is supplied from a radio frequency (RF) oscillator, is incident on the FP-cavity. The transmitted or reflected light from the FP-cavity is observed and converted to an RF signal by a high-speed photodetector, and the RF signal is synchronously demodulated with a lock-in amplifier by referring to a cosine wave signal from the oscillator. We theoretically and experimentally demonstrate that the lock-in amplifier signal for the transmitted or reflected light becomes null with a steep slope when the modulation frequency is equal to the FSR under the condition that the carrier frequency of the laser is slightly detuned from the resonance of the FP-cavity. To reduce the measurement uncertainty for the FSR, we also discuss a selection method for laser power, a modulation index and the detuning shift of the carrier frequency, respectively.
Design and Calibration of an RF Actuator for Low-Level RF Systems
NASA Astrophysics Data System (ADS)
Geng, Zheqiao; Hong, Bo
2016-02-01
X-ray free electron laser (FEL) machines like the Linac Coherent Light Source (LCLS) at SLAC require high-quality electron beams to generate X-ray lasers for various experiments. Digital low-level RF (LLRF) systems are widely used to control the high-power RF klystrons to provide a highly stable RF field in accelerator structures for beam acceleration. Feedback and feedforward controllers are implemented in LLRF systems to stabilize or adjust the phase and amplitude of the RF field. To achieve the RF stability and the accuracy of the phase and amplitude adjustment, low-noise and highly linear RF actuators are required. Aiming for the upgrade of the S-band Linac at SLAC, an RF actuator is designed with an I/Qmodulator driven by two digital-to-analog converters (DAC) for the digital LLRF systems. A direct upconversion scheme is selected for RF actuation, and an on-line calibration algorithm is developed to compensate the RF reference leakage and the imbalance errors in the I/Q modulator, which may cause significant phase and amplitude actuation errors. This paper presents the requirements on the RF actuator, the design of the hardware, the calibration algorithm, and the implementation in firmware and software and the test results at LCLS.
Computational expressions for signals in frequency-modulation spectroscopy.
Di Rosa, Michael D; Reiten, M T
2015-06-01
General expressions for the signals in frequency-modulation spectroscopy (FMS) appear in the literature but are often reduced to simple analytical equations following the assumption of a weak modulation index. This is little help to the experimentalist who wants to predict signals for modulation depths of the order of unity or greater, where strong FMS signals reside. Here, we develop general formulas for FMS signals in the case of an absorber with a Voigt line shape and then link these expressions to an example and existing numerical code for the line shape. The resulting computational recipe is easy to implement and exercised here to show where the larger FMS signals are found over the coordinates of modulation index and modulation frequency. One can also estimate from provided curves the in-phase FMS signal over a wide range of modulation parameters at either the Lorentzian-broadening or Doppler-broadening limit, or anywhere in between by interpolation.
Computational expressions for signals in frequency-modulation spectroscopy
DOE Office of Scientific and Technical Information (OSTI.GOV)
Di Rosa, Michael D.; Reiten, M. T.
2015-05-25
In this study, general expressions for the signals in frequency-modulation spectroscopy (FMS) appear in the literature but are often reduced to simple analytical equations following the assumption of a weak modulation index. This is little help to the experimentalist who wants to predict signals for modulation depths of the order of unity or greater, where strong FMS signals reside. Here, we develop general formulas for FMS signals in the case of an absorber with a Voigt line shape and then link these expressions to an example and existing numerical code for the line shape. The resulting computational recipe is easymore » to implement and exercised here to show where the larger FMS signals are found over the coordinates of modulation index and modulation frequency. One can also estimate from provided curves the in-phase FMS signal over a wide range of modulation parameters at either the Lorentzian-broadening or Doppler-broadening limit, or anywhere in between by interpolation.« less
Automatic Phase Calibration for RF Cavities using Beam-Loading Signals
DOE Office of Scientific and Technical Information (OSTI.GOV)
Edelen, J. P.; Chase, B. E.
Precise calibration of the cavity phase signals is necessary for the operation of any particle accelerator. For many systems this requires human in the loop adjustments based on measurements of the beam parameters downstream. Some recent work has developed a scheme for the calibration of the cavity phase using beam measurements and beam-loading however this scheme is still a multi-step process that requires heavy automation or human in the loop. In this paper we analyze a new scheme that uses only RF signals reacting to beam-loading to calculate the phase of the beam relative to the cavity. This technique couldmore » be used in slow control loops to provide real-time adjustment of the cavity phase calibration without human intervention thereby increasing the stability and reliability of the accelerator.« less
The RF-powered surface wave sensor oscillator--a successful alternative to passive wireless sensing.
Avramov, Ivan D
2004-09-01
A novel, passive wireless surface acoustic wave (SAW) sensor providing a highly coherent measurand proportional frequency, frequency modulated (FM) with identification (ID) data and immune to interference with multiple-path signals is described. The sensor is appropriate for bandwidth-limited applications requiring high-frequency accuracy. It comprises a low-power oscillator, stabilized with the sensing SAW resonator and powered by the rectified radio frequency (RF) power of the interrogating signal received by an antenna on the sensor part. A few hundred microwatts of direct current (DC) power are enough to power the sensor oscillator and ID modulation circuit and achieve stable operation at 1.0 and 2.49 GHz. Reliable sensor interrogation was achieved over a distance of 0.45 m from a SAW-based interrogation unit providing 50 mW of continuous RF power at 915 MHz. The -30 to -35 dBm of returned sensor power was enough to receive the sensor signal over a long distance and through several walls with a simple superheterodyne FM receiver converting the sensor signal to a low measurand proportional intermediate frequency and retrieving the ID data through FM detection. Different sensor implementations, including continuous and pulsed power versions and the possibility of transmitting data from several measurands with a single sensor, are discussed.
A software controllable modular RF signal generator with multichannel transmission capabilities.
Shaw, Z; Feilner, W; Esser, B; Dickens, J C; Neuber, A A
2017-09-01
A software controllable system which generates and transmits user defined RF signals is discussed. The system is implemented with multiple, modular transmitting channels that allow the user to easily replace parts such as amplifiers or antennas. Each channel is comprised of a data pattern generator (DPG), a digital to analog converter (DAC), a power amplifier, and a transmitting antenna. All channels are controlled through a host PC and synchronized through a master clock signal provided to each DAC by an external clock source. Signals to be transmitted are generated through the DPG control software on the PC or can be created by the user in a numerical computing environment. Three experiments are discussed using a two- and four-channel antenna array incorporating Chebyshev tapered TEM horn antennas. Transmitting distinct sets of nonperiodic bipolar impulses through each of the antennas in the array enabled synthesizing a sinusoidal signal of specific frequency in free space. Opposite to the standard phased array approach, each antenna radiates a distinctly different signal rather than the same signal simply phase shifted. The presented approach may be employed as a physical layer of encryption dependent on the position of the receiving antenna.
RF Photonic Technology in Optical Fiber Links
NASA Astrophysics Data System (ADS)
Chang, William S. C.
2007-06-01
List of contributors; Introduction and preface; 1. Figures of merit and performance analysis of photonic microwave links Charles Cox and William S. C. Chang; 2. RF subcarrier links in local access networks Xiaolin Lu; 3. Analog modulation of semiconductor lasers Joachim Piprek and John E. Bowers; 4. LiNbO3 external modulators and their use in high performance analog links Gary E. Betts; 5. Broadband traveling wave modulators in LiNbO3 Marta M. Howerton and William K. Burns; 6. Multiple quantum well electroabsorption modulators for RF photonic links William S. C. Chang; 7. Polymer modulators for RF photonics Timothy Van Eck; 8. Photodiodes for high performance analog links P. K. L. Yu and Ming C. Wu; 9. Opto-electronic oscillators X. Steve Yao; 10. Photonic link techniques for microwave frequency conversion Stephen A. Pappert, Roger Helkey and Ronald T. Logan Jr; 11. Antenna-coupled millimeter-wave electro-optical modulators William B. Bridges; 12. System design and performance of wideband photonic phased array antennas Greg L. Tangonan, Willie Ng, Daniel Yap and Ron Stephens; Acknowledgements; References; Index.
Infrared Avionics Signal Distribution using Wavelength Division Multiplexing
NASA Technical Reports Server (NTRS)
Atiquzzaman, Mohammed; Sluss, Jim; Nguyen, Hung; Ngo, Duc
2003-01-01
Pilots in the cockpits of aircrafts currently communicate with ground stations using Radio Frequency (RF) signals. Antennas mounted outside the aircraft receive and transmit RF signals from and to the ground stations. The RF signals received at the antennas are sent to the cockpit using coaxial cables. As the number of antennas needed to provide more than one frequency band in aircrafts increases, RF distribution media (such as coaxial cable) adds to the complexity and weight of the cockpit wiring. Concomitantly, the safety and signal to noise ratio also decreases due to the use of RF signals. The University of Oklahoma is collaborating with the National Aeronautics and Space Administration to develop optical fiber based schemes to replace the coaxial cable used for RF signal distribution within an aircraft. The project aims at exploiting emerging Wavelength Division Multiplexing (WDM) techniques to reduce the weight of cabling, and increase the signal to noise ratio and reliability. This will be achieved by wavelength division multiplexing the signals from the various antennas and then demultiplexing the signals to recover the original signals at the cockpit. This paper will show that (i) RF signals can not only be wavelength multiplexed at the end of a fiber, but additional signals can be inserted into the middle of the fiber using WDM technology, and (ii) the signals can also be successfully extracted by tapping into the middle of the fiber. We are currently extending our previous laboratory prototype (which could multiplex signals only at the end of the fiber) to include additional multiplexing and demultiplexing of RF signals from the middle of the optical backbone with a view to validating the proof of concept, and carrying out measurements to determine the effectiveness of Wavelength Division Multiplexing for avionics applications. A test bed to perform measurements of several relevant parameters for various modulation schemes and frequencies (such as VHF
Superconductor Digital-RF Receiver Systems
NASA Astrophysics Data System (ADS)
Mukhanov, Oleg A.; Kirichenko, Dmitri; Vernik, Igor V.; Filippov, Timur V.; Kirichenko, Alexander; Webber, Robert; Dotsenko, Vladimir; Talalaevskii, Andrei; Tang, Jia Cao; Sahu, Anubhav; Shevchenko, Pavel; Miller, Robert; Kaplan, Steven B.; Sarwana, Saad; Gupta, Deepnarayan
Digital superconductor electronics has been experiencing rapid maturation with the emergence of smaller-scale, lower-cost communications applications which became the major technology drivers. These applications are primarily in the area of wireless communications, radar, and surveillance as well as in imaging and sensor systems. In these areas, the fundamental advantages of superconductivity translate into system benefits through novel Digital-RF architectures with direct digitization of wide band, high frequency radio frequency (RF) signals. At the same time the availability of relatively small 4K cryocoolers has lowered the foremost market barrier for cryogenically-cooled digital electronic systems. Recently, we have achieved a major breakthrough in the development, demonstration, and successful delivery of the cryocooled superconductor digital-RF receivers directly digitizing signals in a broad range from kilohertz to gigahertz. These essentially hybrid-technology systems combine a variety of superconductor and semiconductor technologies packaged with two-stage commercial cryocoolers: cryogenic Nb mixed-signal and digital circuits based on Rapid Single Flux Quantum (RSFQ) technology, room-temperature amplifiers, FPGA processing and control circuitry. The demonstrated cryocooled digital-RF systems are the world's first and fastest directly digitizing receivers operating with live satellite signals in X-band and performing signal acquisition in HF to L-band at ˜30GHz clock frequencies.
NASA Astrophysics Data System (ADS)
Wang, Zhao; Knights, Andrew P.
2017-02-01
We describe a direct experimental method to determine the effective driving voltage (Vpp) applied to a silicon photonic modulator possessing an impedance mismatch between the unterminated capacitive load and input source. This method thus permits subsequent estimation of the power consumption of an imperfectly terminated device as well as a deduction of load impedance for optimization of termination design. The capacitive load in this paper is a silicon micro-ring modulator with an integrated p-n junction acting as a phase shifter. The RF reflection under high-speed drive is directly determined from observation of the eye-diagram following measurement of the power transfer function for various junction bias.
RF digital-to-analog converter
Conway, Patrick H.; Yu, David U. L.
1995-01-01
A digital-to analogue converter for producing an RF output signal proportional to a digital input word of N bits from an RF reference input, N being an integer greater or equal to 2. The converter comprises a plurality of power splitters, power combiners and a plurality of mixers or RF switches connected in a predetermined configuration.
High frequency modulation and injection locking of terahertz quantum cascade lasers
NASA Astrophysics Data System (ADS)
Gu, L.; Wan, W. J.; Zhu, Y. H.; Fu, Z. L.; Li, H.; Cao, J. C.
2017-06-01
Due to intersubband transitions, the quantum cascade laser (QCL) is free of relaxations and able to work under fast modulations. In this work, the authors investigate the fast modulation properties of a continuous wave (cw) terahertz QCL emitting around 3 THz (˜100 μm). Both simulation and experimental results show that the 3 dB modulation bandwidth for the device can reach 11.5 GHz and the modulation response curve is relatively flat upto ˜16 GHz. The radio frequency (RF) injection measurements verify that around the laser threshold the inter-mode beat note interacts strongly with the RF signal and the laser can be modulated at the round trip frequency of 15.5 GHz.
RF Tomography for Tunnel Detection: Principles and Inversion Schemes
NASA Astrophysics Data System (ADS)
Lo Monte, L.; Erricolo, D.; Inan, U. S.; Wicks, M. C.
2008-12-01
We propose a novel way to detect underground tunnels based on classical seismic tomography, Ground Penetrating Radar (GPR), inverse scattering principles, and the deployment of distributed sensors, which we call "Distributed RF Tomography". Tunnel detection has been a critical problem that cannot be considered fully solved. Presently, tunnel detection is performed by methods that include seismic sensors, electrical impedance, microgravity, boreholes, and GPR. All of these methods have drawbacks that make them not applicable for use in unfriendly environments, such as battlefields. Specifically, they do not cover wide surface areas, they are generally shallow, they are limited to vertical prospecting, and require the user to be in situ, which may jeopardize one's safety. Additional application of the proposed distributed RF tomography include monitoring sensitive areas, (e.g. banks, power plants, military bases, prisons, national borders) and civil applications (e.g. environmental engineering, mine safety, search and rescue, speleology, archaeology and geophysics). The novelty of a Distributed RF tomography system consists of the following. 1) Sensors are scattered randomly above the ground, thus saving time and money compared to the use of boreholes. 2) The use of lower operating frequency (around HF), which allows for deeper penetration. 3) The use of CW diffraction tomography, which increases the resolution to sub-wavelength values, independently from the sensor displacement, and increases the SNR. 4) Use of linear inversion schemes that are suited for tunnel detection. 5) The use of modulation schemes and signal processing algorithms to mitigate interferences and noise. This presentation will cover: 1. Current physical limits of existing techniques for tunnel detection. 2. Concept of Distributed RF Tomography. 3. Inversion theories and strategies a. Proper forward model for voids buried into an homogeneous medium b. Extended matched filtering inversion c. Near
NASA Astrophysics Data System (ADS)
Zong, Kang; Zhu, Jiang
2018-04-01
In this paper, we present a multiband phase-modulated (PM) radio over intersatellite optical wireless communication (IsOWC) link with balanced coherent homodyne detection. The proposed system can provide the transparent transport of multiband radio frequency (RF) signals with higher linearity and better receiver sensitivity than intensity modulated with direct detection (IM/DD) system. The expressions of RF gain, noise figure (NF) and third-order spurious-free dynamic range (SFDR) are derived considering the third-order intermodulation product and amplifier spontaneous emission (ASE) noise. The optimal power of local oscillator (LO) optical signal is also derived theoretically. Numerical results for RF gain, NF and third-order SFDR are given for demonstration. Results indicate that the gain of the optical preamplifier and the power of LO optical signal should be optimized to obtain the satisfactory performance.
RF digital-to-analog converter
Conway, P.H.; Yu, D.U.L.
1995-02-28
A digital-to-analog converter is disclosed for producing an RF output signal proportional to a digital input word of N bits from an RF reference input, N being an integer greater or equal to 2. The converter comprises a plurality of power splitters, power combiners and a plurality of mixers or RF switches connected in a predetermined configuration. 18 figs.
[Amplitude modulation in sound signals by mammals].
Nikol'skiĭ, A A
2012-01-01
Periodic variations in amplitude of a signal, or amplitude modulation (AM), affect the structure of communicative messages spectrum. Within the spectrum of AM-signals, side frequencies are formed both above and below the carrier frequency that is subjected to modulation. In case of harmonic signal structure they are presented near fundamental frequency as well as near harmonics. Thus, AM may by viewed as a relatively simple mechanism for controlling the spectrum of messages transmitted by mammals. Examples of AM affecting the spectrum structure of functionally different sound signals are discussed as applied to representatives of four orders of mammals: rodents (Reodentia), duplicidentates (Lagomorpha), pinnipeds (Pinnipedia), and paridigitates (Artiodactia). For the first time, the classification of AM in animals' sound signals is given. Five forms of AM are picked out in sound signals by mammals: absence of AM, continuous AM, fragmented, heterogeneous, and multilevel one. AM presence/absence is related neither with belonging to any specific order nor with some particular function of a signal. Similar forms of AM can occur in different orders of mammals in parallel. On the contrary, different forms of AM can be detected in signals meant for similar functions. The assumption is made about AM-signals facilitating information encoding and jamprotection of messages transmitted by mammals. Preliminry analysis indicates that hard-driving amplitude modulation is incompatible with hard-driving frequency modulation.
Coherent optical modulation for antenna remoting
NASA Technical Reports Server (NTRS)
Fitzmartin, D. J.; Gels, R. G.; Balboni, E. J.
1991-01-01
A coherent fiber optic link employing wideband frequency modulation (FM) of the optical carrier is used to transfer radio frequency (RF) or microwave signals. This system is used to link a remotely located antenna to a conveniently located electronics processing site. The advantages of coherent analog fiber optic systems over non-coherent intensity modulated fiber optic analog transmission systems are described. An optical FM link employing an indirect transmitter to frequency modulate the optical carrier and a microwave delay line discriminator receiver is described. Measured performance data for a video signal centered at 60 MHz is presented showing the use of wideband FM in the link.
NASA Technical Reports Server (NTRS)
Mcchesney, J. R.; Lerner, T.; Fitch, E. J. (Inventor)
1975-01-01
Tones and binary information are transmitted as phase variations on a carrier wave of constant amplitude and frequency. The carrier and tones are applied to a balanced modulator for deriving an output signal including a pair of sidebands relative to the carrier. The carrier is phase modulated by a digital signal so that it is + or - 90 deg out of phase with the predetermined phase of the carrier. The carrier is combined in an algebraic summing device with the phase modulated signal and the balanced modulator output signal. The output of the algebraic summing device is hard limited to derive a constant amplitude and frequency signal having very narrow bandwidth requirements. At a receiver, the tones and binary data are detected with a phase locked loop having a voltage controlled oscillator driving a pair of orthogonal detection channels.
Multidimensional signal modulation and/or demodulation for data communications
Smith, Stephen F [London, TN; Dress, William B [Camas, WA
2008-03-04
Systems and methods are described for multidimensional signal modulation and/or demodulation for data communications. A method includes modulating a carrier signal in a first domain selected from the group consisting of phase, frequency, amplitude, polarization and spread; modulating the carrier signal in a second domain selected from the group consisting of phase, frequency, amplitude, polarization and spread; and modulating the carrier signal in a third domain selected from the group consisting of phase, frequency, amplitude, polarization and spread.
Modulation of PPAR-Gamma Signaling in Prostatic Carcinogenesis
2009-09-01
AD_________________ AWARD NUMBER: W81XWH-07-1-0479 TITLE: Modulation of PPAR -Gamma Signaling in...REPORT TYPE Annual 3. DATES COVERED 1 Sep 2008 – 1 Sep 2009 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Modulation of PPAR -Gamma Signaling in...4 Annual Report PCRP Idea Development Award W81XWH-07-1-0479 Modulation of PPAR -Gamma Signaling in Prostatic Carcinogenesis P.I. Simon W
Least squares reconstruction of non-linear RF phase encoded MR data.
Salajeghe, Somaie; Babyn, Paul; Sharp, Jonathan C; Sarty, Gordon E
2016-09-01
The numerical feasibility of reconstructing MRI signals generated by RF coils that produce B1 fields with a non-linearly varying spatial phase is explored. A global linear spatial phase variation of B1 is difficult to produce from current confined to RF coils. Here we use regularized least squares inversion, in place of the usual Fourier transform, to reconstruct signals generated in B1 fields with non-linear phase variation. RF encoded signals were simulated for three RF coil configurations: ideal linear, parallel conductors and, circular coil pairs. The simulated signals were reconstructed by Fourier transform and by regularized least squares. The Fourier reconstruction of simulated RF encoded signals from the parallel conductor coil set showed minor distortions over the reconstruction of signals from the ideal linear coil set but the Fourier reconstruction of signals from the circular coil set produced severe geometric distortion. Least squares inversion in all cases produced reconstruction errors comparable to the Fourier reconstruction of the simulated signal from the ideal linear coil set. MRI signals encoded in B1 fields with non-linearly varying spatial phase may be accurately reconstructed using regularized least squares thus pointing the way to the use of simple RF coil designs for RF encoded MRI. Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.
An amplitude modulated radio frequency plasma generator
NASA Astrophysics Data System (ADS)
Lei, Fan; Li, Xiaoping; Liu, Yanming; Liu, Donglin; Yang, Min; Xie, Kai; Yao, Bo
2017-04-01
A glow discharge plasma generator and diagnostic system has been developed to study the effects of rapidly variable plasmas on electromagnetic wave propagation, mimicking the plasma sheath conditions encountered in space vehicle reentry. The plasma chamber is 400 mm in diameter and 240 mm in length, with a 300-mm-diameter unobstructed clear aperture. Electron densities produced are in the mid 1010 electrons/cm3. An 800 W radio frequency (RF) generator is capacitively coupled through an RF matcher to an internally cooled stainless steel electrode to form the plasma. The RF power is amplitude modulated by a waveform generator that operates at different frequencies. The resulting plasma contains electron density modulations caused by the varying power levels. A 10 GHz microwave horn antenna pair situated on opposite sides of the chamber serves as the source and detector of probe radiation. The microwave power feed to the source horn is split and one portion is sent directly to a high-speed recording oscilloscope. On mixing this with the signal from the pickup horn antenna, the plasma-induced phase shift between the two signals gives the path-integrated electron density with its complete time dependent variation. Care is taken to avoid microwave reflections and extensive shielding is in place to minimize electronic pickup. Data clearly show the low frequency modulation of the electron density as well as higher harmonics and plasma fluctuations.
Wei, Wei; Chang, Jun; Wang, Qiang; Qin, Zengguang
2017-01-15
A new technique of modulation index adjustment for pure wavelength modulation spectroscopy second harmonic signal waveforms recovery is presented. As the modulation index is a key parameter in determining the exact form of the signals generated by the technique of wavelength modulation spectroscopy, the method of modulation index adjustment is applied to recover the second harmonic signal with wavelength modulation spectroscopy. By comparing the measured profile with the theoretical profile by calculation, the relationship between the modulation index and average quantities of the scanning wavelength can be obtained. Furthermore, when the relationship is applied in the experimental setup by point-by-point modulation index modification for gas detection, the results show good agreement with the theoretical profile and signal waveform distortion (such as the amplitude modulation effect caused by diode laser) can be suppressed. Besides, the method of modulation index adjustment can be used in many other aspects which involve profile improvement. In practical applications, when the amplitude modulation effect can be neglected and the stability of the detection system is limited by the sampling rate of analog-to-digital, modulation index adjustment can be used to improve detection into softer inflection points and solve the insufficient sampling problem. As a result, measurement stability is improved by 40%.
Wei, Wei; Chang, Jun; Wang, Qiang; Qin, Zengguang
2017-01-01
A new technique of modulation index adjustment for pure wavelength modulation spectroscopy second harmonic signal waveforms recovery is presented. As the modulation index is a key parameter in determining the exact form of the signals generated by the technique of wavelength modulation spectroscopy, the method of modulation index adjustment is applied to recover the second harmonic signal with wavelength modulation spectroscopy. By comparing the measured profile with the theoretical profile by calculation, the relationship between the modulation index and average quantities of the scanning wavelength can be obtained. Furthermore, when the relationship is applied in the experimental setup by point-by-point modulation index modification for gas detection, the results show good agreement with the theoretical profile and signal waveform distortion (such as the amplitude modulation effect caused by diode laser) can be suppressed. Besides, the method of modulation index adjustment can be used in many other aspects which involve profile improvement. In practical applications, when the amplitude modulation effect can be neglected and the stability of the detection system is limited by the sampling rate of analog-to-digital, modulation index adjustment can be used to improve detection into softer inflection points and solve the insufficient sampling problem. As a result, measurement stability is improved by 40%. PMID:28098842
Performance of mixed RF/FSO systems in exponentiated Weibull distributed channels
NASA Astrophysics Data System (ADS)
Zhao, Jing; Zhao, Shang-Hong; Zhao, Wei-Hu; Liu, Yun; Li, Xuan
2017-12-01
This paper presented the performances of asymmetric mixed radio frequency (RF)/free-space optical (FSO) system with the amplify-and-forward relaying scheme. The RF channel undergoes Nakagami- m channel, and the Exponentiated Weibull distribution is adopted for the FSO component. The mathematical formulas for cumulative distribution function (CDF), probability density function (PDF) and moment generating function (MGF) of equivalent signal-to-noise ratio (SNR) are achieved. According to the end-to-end statistical characteristics, the new analytical expressions of outage probability are obtained. Under various modulation techniques, we derive the average bit-error-rate (BER) based on the Meijer's G function. The evaluation and simulation are provided for the system performance, and the aperture average effect is discussed as well.
Controlling satellite communication system unwanted emissions in congested RF spectrum
NASA Astrophysics Data System (ADS)
Olsen, Donald; Heymann, Roger
2007-09-01
, developed by the European Telecommunications Standards Institute (ETSI). In the USA, the Advanced Television Systems Committee (ATSC) has adopted Europe's DVB-S and DVB-S2 standards for satellite digital transmission. With today's digital modulations, RF spectral side lobes can extend out many times the modulating frequency on either side of the carrier at excessive power levels unless filtered. Higher-order digital modulations include quadrature phase shift keying (QPSK), 8 PSK (8-ary phase shift keying), 16 APSK (also called 12-4 APSK (amplitude phase shift keying)), and 16 QAM (quadrature amplitude modulation); they are key for higher spectrum efficiency to enable higher data rate transmissions in limited available bandwidths. Nonlinear high-power amplifiers (HPAs) can regenerate frequency spectral side lobes on input-filtered digital modulations. The paper discusses technologies and techniques for controlling these spectral side lobes, such as the use of square root raised cosine (SRRC) filtering before or during the modulation process, HPA output power back-off (OPBO), and RF filters after the HPA. Spectral mask specifications are a common method of the NTIA and ITU to define spectral occupancy power limits. They are intended to reduce interference among RF spectrum users by limiting excessive radiation at frequencies beyond the regulatory allocated bandwidth.The focus here is on the communication systems of U.S. government satellites used for space research, space operations, Earth exploration satellite services (EESS), meteorological satellite services (METSATS), and other government services. The 8025 to 8400 megahertz (MHz) X band can be used to illustrate the "unwanted emissions" issue. 8025 to 8400 MHz abuts the 8400 to 8450 MHz band allocated by the NTIA and ITU to space research for space-to-Earth transmissions such as receiving very weak Deep Space Network signals. The views and ideas expressed in this paper are those of the authors and do not necessarily
Flexible, reconfigurable, power efficient transmitter and method
NASA Technical Reports Server (NTRS)
Bishop, James W. (Inventor); Zaki, Nazrul H. Mohd (Inventor); Newman, David Childress (Inventor); Bundick, Steven N. (Inventor)
2011-01-01
A flexible, reconfigurable, power efficient transmitter device and method is provided. In one embodiment, the method includes receiving outbound data and determining a mode of operation. When operating in a first mode the method may include modulation mapping the outbound data according a modulation scheme to provide first modulation mapped digital data, converting the first modulation mapped digital data to an analog signal that comprises an intermediate frequency (IF) analog signal, upconverting the IF analog signal to produce a first modulated radio frequency (RF) signal based on a local oscillator signal, amplifying the first RF modulated signal to produce a first RF output signal, and outputting the first RF output signal via an isolator. In a second mode of operation method may include modulation mapping the outbound data according a modulation scheme to provide second modulation mapped digital data, converting the second modulation mapped digital data to a first digital baseband signal, conditioning the first digital baseband signal to provide a first analog baseband signal, modulating one or more carriers with the first analog baseband signal to produce a second modulated RF signal based on a local oscillator signal, amplifying the second RF modulated signal to produce a second RF output signal, and outputting the second RF output signal via the isolator. The digital baseband signal may comprise an in-phase (I) digital baseband signal and a quadrature (Q) baseband signal.
Choi, Sang-Jin; Mao, Wankai; Pan, Jae-Kyung
2013-01-01
We propose and experimentally demonstrate the novel radio-frequency (RF) interrogation of a fiber Bragg grating (FBG) sensor using bidirectional modulation of a Mach-Zehnder electro-optical modulator (MZ-EOM). Based on the microwave photonic technique and active detection, the transfer function of the proposed system was obtained, and the time delay was calculated from the change in the free spectral range (FSR) at different wavelengths over the optimal measuring range. The results show that the time delay and the wavelength variation have a good linear relationship, with a gradient of 9.31 ps/nm. An actual measurement taken with a sensing FBG for temperature variation shows the relationship with a gradient of 0.93 ps/10 °C. The developed system could be used for FBG temperature or strain sensing and other multiplexed sensor applications. PMID:23820744
NASA Astrophysics Data System (ADS)
Zhang, S.; Sobota, A.; van Veldhuizen, E. M.; Bruggeman, P. J.
2015-08-01
The ozone density distribution in the effluent of a time modulated RF atmospheric pressure plasma jet (APPJ) is investigated by time and spatially resolved by UV absorption spectroscopy. The plasma jet is operated with an averaged dissipated power of 6.5 W and gas flow rate 2 slm argon +2% O2. The modulation frequency of the RF power is 50 Hz with a duty cycle of 50%. To investigate the production and destruction mechanism of ozone in the plasma effluent, the atomic oxygen and gas temperature is also obtained by TALIF and Rayleigh scattering, respectively. A temporal increase in ozone density is observed close to the quartz tube exit when the plasma is switched off due to the decrease in O density and gas temperature. Ozone absorption at different axial positions indicates that the ozone distribution is dominated by the convection induced by the gas flow and allows estimating the on-axis local gas velocity in the jet effluent. Transient vortex structures occurring during the switch on and off of the RF power also significantly affect the ozone density in the far effluent.
Signaling cascades modulate the speed of signal propagation through space.
Govern, Christopher C; Chakraborty, Arup K
2009-01-01
Cells are not mixed bags of signaling molecules. As a consequence, signals must travel from their origin to distal locations. Much is understood about the purely diffusive propagation of signals through space. Many signals, however, propagate via signaling cascades. Here, we show that, depending on their kinetics, cascades speed up or slow down the propagation of signals through space, relative to pure diffusion. We modeled simple cascades operating under different limits of Michaelis-Menten kinetics using deterministic reaction-diffusion equations. Cascades operating far from enzyme saturation speed up signal propagation; the second mobile species moves more quickly than the first through space, on average. The enhanced speed is due to more efficient serial activation of a downstream signaling module (by the signaling molecule immediately upstream in the cascade) at points distal from the signaling origin, compared to locations closer to the source. Conversely, cascades operating under saturated kinetics, which exhibit zero-order ultrasensitivity, can slow down signals, ultimately localizing them to regions around the origin. Signal speed modulation may be a fundamental function of cascades, affecting the ability of signals to penetrate within a cell, to cross-react with other signals, and to activate distant targets. In particular, enhanced speeds provide a way to increase signal penetration into a cell without needing to flood the cell with large numbers of active signaling molecules; conversely, diminished speeds in zero-order ultrasensitive cascades facilitate strong, but localized, signaling.
A 2×1 Coplanar Monopole Antenna Structure for Wireless RF Energy Harvesting
NASA Astrophysics Data System (ADS)
Mathur, Monika; Agarwal, Ankit; Singh, Ghanshyam; Bhatnagar, S. K.
2018-03-01
The objective of this paper is to design an efcient wireless energy harvesting (WEH) system to eliminate the problem to continuous charging of a battery operated electronics devices. Most of the devices are battery operated so charging of a battery time to time is serious issue. This WEH system receives the Radio Frequency (RF) and Microwave frequency signals present in the atmosphere and converting it into DC signal so that it can stores in Capacitor or charges a battery for utilize the power. For this RF energy harvesting purposes 21 antenna array structure of the coplanar monopole antenna is presented. This structure shows the gain of 10.2 dBi and 83% efciency. This structure is designed for resonating on multiple bands (Radio, GSM, ISM, and UWB). It is useful for this application because it covers almost all useful bands in the maximum capturing area. The antenna can be connected directly to an RF-DC converter module and it uses about 60% of the total PCB area. And RF to DC convertor circuit can be implemented in that remaining 40% area on the same substrate so it eliminates the need of port connectors and impedance matching circuit between them. This design is worked in receiving mode only when used for energy harvesting purposes. This may be useful for the biomedical and satellite applications.
Tantawi, Sami G.; Vlieks, Arnold E.
1998-09-01
A compact high-power RF load comprises a series of very low Q resonators, or chokes [16], in a circular waveguide [10]. The sequence of chokes absorb the RF power gradually in a short distance while keeping the bandwidth relatively wide. A polarizer [12] at the input end of the load is provided to convert incoming TE.sub.10 mode signals to circularly polarized TE.sub.11 mode signals. Because the load operates in the circularly polarized mode, the energy is uniformly and efficiently absorbed and the load is more compact than a rectangular load. Using these techniques, a load having a bandwidth of 500 MHz can be produced with an average power dissipation level of 1.5 kW at X-band, and a peak power dissipation of 100 MW. The load can be made from common lossy materials, such as stainless steel, and is less than 15 cm in length. These techniques can also produce loads for use as an alternative to ordinary waveguide loads in small and medium RF accelerators, in radar systems, and in other microwave applications. The design is easily scalable to other RF frequencies and adaptable to the use of other lossy materials.
Active high-power RF switch and pulse compression system
Tantawi, Sami G.; Ruth, Ronald D.; Zolotorev, Max
1998-01-01
A high-power RF switching device employs a semiconductor wafer positioned in the third port of a three-port RF device. A controllable source of directed energy, such as a suitable laser or electron beam, is aimed at the semiconductor material. When the source is turned on, the energy incident on the wafer induces an electron-hole plasma layer on the wafer, changing the wafer's dielectric constant, turning the third port into a termination for incident RF signals, and. causing all incident RF signals to be reflected from the surface of the wafer. The propagation constant of RF signals through port 3, therefore, can be changed by controlling the beam. By making the RF coupling to the third port as small as necessary, one can reduce the peak electric field on the unexcited silicon surface for any level of input power from port 1, thereby reducing risk of damaging the wafer by RF with high peak power. The switch is useful to the construction of an improved pulse compression system to boost the peak power of microwave tubes driving linear accelerators. In this application, the high-power RF switch is placed at the coupling iris between the charging waveguide and the resonant storage line of a pulse compression system. This optically controlled high power RF pulse compression system can handle hundreds of Megawatts of power at X-band.
Silicon Micromachining in RF and Photonic Applications
NASA Technical Reports Server (NTRS)
Lin, Tsen-Hwang; Congdon, Phil; Magel, Gregory; Pang, Lily; Goldsmith, Chuck; Randall, John; Ho, Nguyen
1995-01-01
Texas Instruments (TI) has developed membrane and micromirror devices since the late 1970s. An eggcrate space membrane was used as the spatial light modulator in the early years. Discrete micromirrors supported by cantilever beams created a new era for micromirror devices. Torsional micromirror and flexure-beam micromirror devices were promising for mass production because of their stable supports. TI's digital torsional micromirror device is an amplitude modulator (known as the digital micromirror device (DMD) and is in production development, discussed elsewhere. We also use a torsional device for a 4 x 4 fiber-optic crossbar switch in a 2 cm x 2 cm package. The flexure-beam micromirror device is an analog phase modulator and is considered more efficient than amplitude modulators for use in optical processing systems. TI also developed millimeter-sized membranes for integrated optical switches for telecommunication and network applications. Using a member in radio frequency (RF) switch applications is a rapidly growing area because of the micromechanical device performance in microsecond-switching characteristics. Our preliminary membrane RF switch test structure results indicate promising speed and RF switching performance. TI collaborated with MIT for modeling of metal-based micromachining.
Microfluidic stretchable RF electronics.
Cheng, Shi; Wu, Zhigang
2010-12-07
Stretchable electronics is a revolutionary technology that will potentially create a world of radically different electronic devices and systems that open up an entirely new spectrum of possibilities. This article proposes a microfluidic based solution for stretchable radio frequency (RF) electronics, using hybrid integration of active circuits assembled on flex foils and liquid alloy passive structures embedded in elastic substrates, e.g. polydimethylsiloxane (PDMS). This concept was employed to implement a 900 MHz stretchable RF radiation sensor, consisting of a large area elastic antenna and a cluster of conventional rigid components for RF power detection. The integrated radiation sensor except the power supply was fully embedded in a thin elastomeric substrate. Good electrical performance of the standalone stretchable antenna as well as the RF power detection sub-module was verified by experiments. The sensor successfully detected the RF radiation over 5 m distance in the system demonstration. Experiments on two-dimensional (2D) stretching up to 15%, folding and twisting of the demonstrated sensor were also carried out. Despite the integrated device was severely deformed, no failure in RF radiation sensing was observed in the tests. This technique illuminates a promising route of realizing stretchable and foldable large area integrated RF electronics that are of great interest to a variety of applications like wearable computing, health monitoring, medical diagnostics, and curvilinear electronics.
NASA Astrophysics Data System (ADS)
Ogawa, Kuniyasu; Haishi, Tomoyuki; Aoki, Masaru; Hasegawa, Hiroshi; Morisaka, Shinichi; Hashimoto, Seitaro
2017-01-01
A small radio-frequency (rf) coil inserted into a polymer electrolyte fuel cell (PEFC) can be used to acquire nuclear magnetic resonance (NMR) signals from the water in a membrane electrode assembly (MEA) or in oxygen gas channels in the PEFC. Measuring the spatial distribution of the water in a large PEFC requires using many rf probes, so an NMR measurement system which acquires NMR signals from 128 rf probes at intervals of 0.5 s was manufactured. The system has eight rf transceiver units with a field-programmable gate array (FPGA) for modulation of the excitation pulse and quadrature phase detection of the NMR signal, and one control unit with two ring buffers for data control. The sequence data required for the NMR measurement were written into one ring buffer. The acquired NMR signal data were then written temporarily into the other ring buffer and then were transmitted to a personal computer (PC). A total of 98 rf probes were inserted into the PEFC that had an electrical generation area of 16 cm × 14 cm, and the water generated in the PEFC was measured when the PEFC operated at 100 A. As a result, time-dependent changes in the spatial distribution of the water content in the MEA and the water in the oxygen gas channels were obtained.
Murbach, Manuel; Christopoulou, Maria; Crespo-Valero, Pedro; Achermann, Peter; Kuster, Niels
2012-09-01
A novel exposure system for double-blind human electromagnetic provocation studies has been developed that satisfies the precision, control of fields and potential artifacts, and provides the flexibility to investigate the response of hypotheses-driven electromagnetic field exposure schemes on brain function, ranging from extremely low frequency (ELF) to radio frequency (RF) fields. The system can provide the same exposure of the lateral cerebral cortex at two different RF frequencies (900 and 2140 MHz) but with different exposure levels at subcortical structures, and also allows uniform ELF magnetic field exposure of the brain. The RF modulation and ELF signal are obtained by a freely programmable arbitrary signal generator allowing a wide range of worst-case exposure scenarios to be simulated, including those caused by wireless devices. The maximum achievable RF exposure is larger than 60 W/kg peak spatial specific absorption rate averaged over 10 g of tissue. The maximum ELF magnetic field exposure of the brain is 800 A/m at 50 Hz with a deviation from uniformity of 8% (SD). Copyright © 2012 Wiley Periodicals, Inc.
CEBAF Superconducting Cavity RF Drive System
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fugitt, Jock; Moore, Thomas
1987-03-01
The CEBAR RF system consists of 418 individual RF amplifier chains. Each superconducting cavity is phase locked to the master drive reference line to within 1 degree, and the cavity field gradient is regulated to within 1 part in 10 by a state-of-the-art RF control module. Precision, continuously adjustable, modulo 360 phase shifters are used to generate the individual phase references, and a compensated RF detector is used for level feedback. The close coupled digital system enhances system accuracy, provides self-calibration, and continuously checks the system for malfunction. Calibration curves, the operating program, and system history are stored in anmore » on board EEPROM. The RF power is generated by a 5Kw, water cooled, permanent magnet focused klystorn. The klystons are clustered in groups of 8 and powered from a common supply. RF power is transmitted to the accelerator sections by semiflexible waveguide.« less
Analog and digital transport of RF channels over converged 5G wireless-optical networks
NASA Astrophysics Data System (ADS)
Binh, Le Nguyen
2016-02-01
Under the exponential increase demand by the emerging 5G wireless access networking and thus data-center based Internet, novel and economical transport of RF channels to and from wireless access systems. This paper presents the transport technologies of RF channels over the analog and digital domain so as to meet the demands of the transport capacity reaching multi-Tbps, in the followings: (i) The convergence of 5G broadband wireless and optical networks and its demands on capacity delivery and network structures; (ii) Analog optical technologies for delivery of both the information and RF carriers to and from multiple-input multiple-output (MIMO) antenna sites so as to control the beam steering of MIMO antenna in the mmW at either 28.6 GHz and 56.8 GHz RF carrier and delivery of channels of aggregate capacity reaching several Tbps; (ii) Transceiver employing advanced digital modulation formats and digital signal processing (DSP) so as to provide 100G and beyond transmission rate to meet the ultra-high capacity demands with flexible spectral grids, hence pay-on-demand services. The interplay between DSP-based and analog transport techniques is examined; (iii) Transport technologies for 5G cloud access networks and associate modulation and digital processing techniques for capacity efficiency; and (iv) Finally the integrated optic technologies with novel lasers, comb generators and simultaneous dual function photonic devices for both demultiplexing/multiplexing and modulation are proposed, hence a system on chip structure can be structured. Quantum dot lasers and matrixes of micro ring resonators are integrated on the same Si-on-Silica substrate are proposed and described.
Hybrid recursive active filters for duplexing in RF transmitter front-ends
NASA Astrophysics Data System (ADS)
Gottardo, Giuseppe; Donati, Giovanni; Musolff, Christian; Fischer, Georg; Felgentreff, Tilman
2016-08-01
Duplex filters in modern base transceiver stations shape the channel in order to perform common frequency division duplex operations. Usually, they are designed as cavity filters, which are expensive and have large dimensions. Thanks to the emerging digital technology and fast digital converters, it is possible to transfer the efforts of designing analog duplex filters into digital numeric algorithms applied to feedback structures, operating on power. This solution provides the shaping of the signal spectrum directly at the output of the radio frequency (RF) power amplifiers (PAs) relaxing the transmitter design especially in the duplexer and in the antenna sections. The design of a digital baseband feedback applied to the analog power RF amplifiers (hybrid filter) is presented and verified by measurements. A model to describe the hybrid system is investigated, and the relation between phase and resonance peaks of the resulting periodic band-pass transfer function is described. The stability condition of the system is analyzed using Nyquist criterion. A solution involving a number of digital feedback and forward branches is investigated defining the parameters of the recursive structure. This solution allows the closed loop system to show a periodic band pass with up to 500 kHz bandwidth at the output of the RF amplifier. The band-pass magnitude reaches up to 17 dB selectivity. The rejection of the PA noise in the out-of-band frequencies is verified by measurements. The filter is tested with a modulated LTE (Long Term Evolution) signal showing an ACPR (Adjacent Channel Power Ratio) enhancement of 10 dB of the transmitted signal.
Lamp modulator provides signal magnitude indication
NASA Technical Reports Server (NTRS)
Zeman, J. R.
1970-01-01
Lamp modulator provides visible indication of presence and magnitude of an audio signal carrying voice or data. It can be made to reflect signal variations of up to 32 decibels. Lamp life is increased by use of a bypass resistor to prevent filament failure.
Zimbelman, Eloise G; Keefe, Robert F
2018-01-01
Real-time positioning on mobile devices using global navigation satellite system (GNSS) technology paired with radio frequency (RF) transmission (GNSS-RF) may help to improve safety on logging operations by increasing situational awareness. However, GNSS positional accuracy for ground workers in motion may be reduced by multipath error, satellite signal obstruction, or other factors. Radio propagation of GNSS locations may also be impacted due to line-of-sight (LOS) obstruction in remote, forested areas. The objective of this study was to characterize the effects of forest stand characteristics, topography, and other LOS obstructions on the GNSS accuracy and radio signal propagation quality of multiple Raveon Atlas PT GNSS-RF transponders functioning as a network in a range of forest conditions. Because most previous research with GNSS in forestry has focused on stationary units, we chose to analyze units in motion by evaluating the time-to-signal accuracy of geofence crossings in 21 randomly-selected stands on the University of Idaho Experimental Forest. Specifically, we studied the effects of forest stand characteristics, topography, and LOS obstructions on (1) the odds of missed GNSS-RF signals, (2) the root mean squared error (RMSE) of Atlas PTs, and (3) the time-to-signal accuracy of safety geofence crossings in forested environments. Mixed-effects models used to analyze the data showed that stand characteristics, topography, and obstructions in the LOS affected the odds of missed radio signals while stand variables alone affected RMSE. Both stand characteristics and topography affected the accuracy of geofence alerts.
2018-01-01
Real-time positioning on mobile devices using global navigation satellite system (GNSS) technology paired with radio frequency (RF) transmission (GNSS-RF) may help to improve safety on logging operations by increasing situational awareness. However, GNSS positional accuracy for ground workers in motion may be reduced by multipath error, satellite signal obstruction, or other factors. Radio propagation of GNSS locations may also be impacted due to line-of-sight (LOS) obstruction in remote, forested areas. The objective of this study was to characterize the effects of forest stand characteristics, topography, and other LOS obstructions on the GNSS accuracy and radio signal propagation quality of multiple Raveon Atlas PT GNSS-RF transponders functioning as a network in a range of forest conditions. Because most previous research with GNSS in forestry has focused on stationary units, we chose to analyze units in motion by evaluating the time-to-signal accuracy of geofence crossings in 21 randomly-selected stands on the University of Idaho Experimental Forest. Specifically, we studied the effects of forest stand characteristics, topography, and LOS obstructions on (1) the odds of missed GNSS-RF signals, (2) the root mean squared error (RMSE) of Atlas PTs, and (3) the time-to-signal accuracy of safety geofence crossings in forested environments. Mixed-effects models used to analyze the data showed that stand characteristics, topography, and obstructions in the LOS affected the odds of missed radio signals while stand variables alone affected RMSE. Both stand characteristics and topography affected the accuracy of geofence alerts. PMID:29324794
NASA Astrophysics Data System (ADS)
Zenick, Raymond; Kohlhepp, Kimberly; Partch, Russell
2004-09-01
AeroAstro's patented RF Probe is a system designed to address the needs of spacecraft developers and operators interested in measuring and analyzing near-field RF emissions emanating from a nearby spacecraft of interest. The RF Probe consists of an intelligent spectrum analyzer with digital signal processing capabilities combined with a calibrated, wide-bandwidth antenna and RF front end that covers the 50 kHz to 18 GHz spectrum. It is capable of acquiring signal level and signal vector information, classifying signals, assessing the quality of a satellite"s transponders, and characterizing near-field electromagnetic emissions. The RF Probe is intended for either incorporation as part of a suite of spacecraft sensors, or as a stand-alone sensor on spacecraft or other platforms such as Unmanned Aerial Vehicles (UAVs). The RF Probe was initially conceived as a tool to detect and aid in diagnosis of malfunctions in a spacecraft of interest. However, the utility of the RF Probe goes far beyond this initial concept, spanning a wide range of military applications. Most importantly, the RF Probe can provide space situational awareness for critical on-orbit assets by detecting externally induced RF fields, aiding in protection against potentially devastating attacks.
Long, Yun; Zhou, Linjie; Wang, Jian
2016-01-01
Photonic generation of microwave signal is obviously attractive for many prominent advantages, such as large bandwidth, low loss, and immunity to electromagnetic interference. Based on a single integrated silicon Mach–Zehnder modulator (MZM), we propose and experimentally demonstrate a simple and compact photonic scheme to enable frequency-multiplicated microwave signal. Using the fabricated integrated MZM, we also demonstrate the feasibility of microwave amplitude-shift keying (ASK) modulation based on integrated photonic approach. In proof-of-concept experiments, 2-GHz frequency-doubled microwave signal is generated using a 1-GHz driving signal. 750-MHz/1-GHz frequency-tripled/quadrupled microwave signals are obtained with a driving signal of 250 MHz. In addition, a 50-Mb/s binary amplitude coded 1-GHz microwave signal is also successfully generated. PMID:26832305
Zhu, Zihang; Zhao, Shanghong; Zheng, Wanze; Wang, Wei; Lin, Baoqin
2015-11-10
A novel frequency 12-tupling optical millimeter-wave (mm-wave) generation using two cascaded dual-parallel Mach-Zehnder modulators (DP-MZMs) without an optical filter is proposed and demonstrated by computer simulation. By properly adjusting the amplitude and phase of radio frequency (RF) driving signal and the direct current (DC) bias points of two DP-MZMs, a 120 GHz mm-wave with an optical sideband suppression ratio (OSSR) of 25.1 dB and a radio frequency spurious suppression ratio (RFSSR) of 19.1 dB is shown to be generated from a 10 GHz RF driving signal, which largely reduces the response frequency of electronic devices. Furthermore, it is also proved to be valid that even if the phase difference of RF driving signals, the RF driving voltage, and the DC bias voltage deviate from the ideal values to a certain degree, the performance is still acceptable. Since no optical filter is employed to suppress the undesired optical sidebands, a high-spectral-purity mm-wave signal tunable from 48 to 216 GHz can be obtained theoretically when a RF driving signal from 4 to 18 GHz is applied to the DP-MZMs, and the system can be readily implemented in wavelength-division-multiplexing upconversion systems to provide high-quality optical local oscillator signal.
Assessment of general public exposure to LTE and RF sources present in an urban environment.
Joseph, Wout; Verloock, Leen; Goeminne, Francis; Vermeeren, Günter; Martens, Luc
2010-10-01
For the first time, in situ electromagnetic field exposure of the general public to fields from long term evolution (LTE) cellular base stations is assessed. Exposure contributions due to different radiofrequency (RF) sources are compared with LTE exposure at 30 locations in Stockholm, Sweden. Total exposures (0.2-2.6 V/m) satisfy the International Commission on Non-Ionizing Radiation Protection (ICNIRP) reference levels (from 28 V/m for frequency modulation (FM), up to 61 V/m for LTE) at all locations. LTE exposure levels up to 0.8 V/m were measured, and the average contribution of the LTE signal to the total RF exposure equals 4%.
Load-induced modulation of signal transduction networks.
Jiang, Peng; Ventura, Alejandra C; Sontag, Eduardo D; Merajver, Sofia D; Ninfa, Alexander J; Del Vecchio, Domitilla
2011-10-11
Biological signal transduction networks are commonly viewed as circuits that pass along information--in the process amplifying signals, enhancing sensitivity, or performing other signal-processing tasks--to transcriptional and other components. Here, we report on a "reverse-causality" phenomenon, which we call load-induced modulation. Through a combination of analytical and experimental tools, we discovered that signaling was modulated, in a surprising way, by downstream targets that receive the signal and, in doing so, apply what in physics is called a load. Specifically, we found that non-intuitive changes in response dynamics occurred for a covalent modification cycle when load was present. Loading altered the response time of a system, depending on whether the activity of one of the enzymes was maximal and the other was operating at its minimal rate or whether both enzymes were operating at submaximal rates. These two conditions, which we call "limit regime" and "intermediate regime," were associated with increased or decreased response times, respectively. The bandwidth, the range of frequency in which the system can process information, decreased in the presence of load, suggesting that downstream targets participate in establishing a balance between noise-filtering capabilities and a circuit's ability to process high-frequency stimulation. Nodes in a signaling network are not independent relay devices, but rather are modulated by their downstream targets.
Digital Low Level RF Systems for Fermilab Main Ring and Tevatron
NASA Astrophysics Data System (ADS)
Chase, B.; Barnes, B.; Meisner, K.
1997-05-01
At Fermilab, a new Low Level RF system is successfully installed and operating in the Main Ring. Installation is proceeding for a Tevatron system. This upgrade replaces aging CAMAC/NIM components for an increase in accuracy, reliability, and flexibility. These VXI systems are based on a custom three channel direct digital synthesizer(DDS) module. Each synthesizer channel is capable of independent or ganged operation for both frequency and phase modulation. New frequency and phase values are computed at a 100kHz rate on the module's Analog Devices ADSP21062 (SHARC) digital signal processor. The DSP concurrently handles feedforward, feedback, and beam manipulations. Higher level state machines and the control system interface are handled at the crate level using the VxWorks operating system. This paper discusses the hardware, software and operational aspects of these LLRF systems.
Electrooptic modulation methods for high sensitivity tunable diode laser spectroscopy
NASA Technical Reports Server (NTRS)
Glenar, David A.; Jennings, Donald E.; Nadler, Shacher
1990-01-01
A CdTe phase modulator and low power RF sources have been used with Pb-salt tunable diode lasers operating near 8 microns to generate optical sidebands for high sensitivity absorption spectroscopy. Sweep averaged, first-derivative sample spectra of CH4 were acquired by wideband phase sensitive detection of the electrooptically (EO) generated carrier-sideband beat signal. EO generated beat signals were also used to frequency lock the TDL to spectral lines. This eliminates low frequency diode jitter, and avoids the excess laser linewidth broadening that accompanies TDL current modulation frequency locking methods.
A low-loss, single-pole, four-throw RF MEMS switch driven by a double stop comb drive
NASA Astrophysics Data System (ADS)
Kang, S.; Kim, H. C.; Chun, K.
2009-03-01
Our goal was to develop a single-pole four-throw (SP4T) radio frequency microelectromechanical system (RF MEMS) switch for band selection in a multi-band, multi-mode, front-end module of a wireless transceiver system. The SP4T RF MEMS switch was based on an arrangement of four single-pole single-throw (SPST) RF MEMS switches. The SP4T RF MEMS switch was driven by a double stop (DS) comb drive, with a lateral resistive contact, and composed of single crystalline silicon (SCS) on glass. A large contact force at a low-drive voltage was achieved by electrostatic actuation of the DS comb drive. Good RF characteristics were achieved by the large contact force and the lateral resistive Au-to-Au contact. Mechanical reliability was achieved by using SCS which has no residual stress as a structure material. The developed SP4T RF MEMS switch has a drive voltage of 15 V, an insertion loss below 0.31 dB at 6 GHz after more than one million cycles under a 10 mW signal, a return loss above 20 dB and an isolation value above 36 dB.
Accurate measurement of RF exposure from emerging wireless communication systems
NASA Astrophysics Data System (ADS)
Letertre, Thierry; Monebhurrun, Vikass; Toffano, Zeno
2013-04-01
Isotropic broadband probes or spectrum analyzers (SAs) may be used for the measurement of rapidly varying electromagnetic fields generated by emerging wireless communication systems. In this paper this problematic is investigated by comparing the responses measured by two different isotropic broadband probes typically used to perform electric field (E-field) evaluations. The broadband probes are submitted to signals with variable duty cycles (DC) and crest factors (CF) either with or without Orthogonal Frequency Division Multiplexing (OFDM) modulation but with the same root-mean-square (RMS) power. The two probes do not provide accurate enough results for deterministic signals such as Worldwide Interoperability for Microwave Access (WIMAX) or Long Term Evolution (LTE) as well as for non-deterministic signals such as Wireless Fidelity (WiFi). The legacy measurement protocols should be adapted to cope for the emerging wireless communication technologies based on the OFDM modulation scheme. This is not easily achieved except when the statistics of the RF emission are well known. In this case the measurement errors are shown to be systematic and a correction factor or calibration can be applied to obtain a good approximation of the total RMS power.
Influence of modulation frequency in rubidium cell frequency standards
NASA Technical Reports Server (NTRS)
Audoin, C.; Viennet, J.; Cyr, N.; Vanier, J.
1983-01-01
The error signal which is used to control the frequency of the quartz crystal oscillator of a passive rubidium cell frequency standard is considered. The value of the slope of this signal, for an interrogation frequency close to the atomic transition frequency is calculated and measured for various phase (or frequency) modulation waveforms, and for several values of the modulation frequency. A theoretical analysis is made using a model which applies to a system in which the optical pumping rate, the relaxation rates and the RF field are homogeneous. Results are given for sine-wave phase modulation, square-wave frequency modulation and square-wave phase modulation. The influence of the modulation frequency on the slope of the error signal is specified. It is shown that the modulation frequency can be chosen as large as twice the non-saturated full-width at half-maximum without a drastic loss of the sensitivity to an offset of the interrogation frequency from center line, provided that the power saturation factor and the amplitude of modulation are properly adjusted.
RF low-level control for the Linac4 H{sup −} source
DOE Office of Scientific and Technical Information (OSTI.GOV)
Butterworth, A., E-mail: andrew.butterworth@cern.ch; Grudiev, A.; Lettry, J.
2015-04-08
The H{sup −} source for the Linac4 accelerator at CERN uses an RF driven plasma for the production of H{sup −}. The RF is supplied by a 2 MHz RF tube amplifier with a maximum power output of 100 kW and a pulse duration of up to 2 ms. The low-level RF signal generation and measurement system has been developed using standard CERN controls electronics in the VME form factor. The RF frequency and amplitude reference signals are generated using separate arbitrary waveform generator channels. The frequency and amplitude are both freely programmable over the duration of the RF pulse, which allowsmore » fine-tuning of the excitation. Measurements of the forward and reverse RF power signals are performed via directional couplers using high-speed digitizers, and permit the estimation of the plasma impedance and deposited power via an equivalent circuit model. The low-level RF hardware and software implementations are described, and experimental results obtained with the Linac4 ion sources in the test stand are presented.« less
NASA Astrophysics Data System (ADS)
Ito, Kazuhito; Nakagawa, Seiji
2015-07-01
A novel hearing aid system utilizing amplitude-modulated bone-conducted ultrasound (AM-BCU) is being developed for use by profoundly deaf people. However, there is a lack of research on the acoustic aspects of AM-BCU hearing. In this study, acoustic fields in the ear canal under AM-BCU stimulation were examined with respect to the self-demodulation effect of amplitude-modulated signal components generated in the ear canal. We found self-demodulated signals with an audible sound pressure level related to the amplitude-modulated signal components of bone-conducted ultrasonic stimulation. In addition, the increases in the self-demodulated signal levels at low frequencies in the ear canal after occluding the ear canal opening, i.e., the positive occlusion effect, indicate the existence of a pathway by which the self-demodulated signals pass through the aural cartilage and soft tissue, and radiate into the ear canal.
Zhang, Shengzhao; Li, Gang; Wang, Jiexi; Wang, Donggen; Han, Ying; Cao, Hui; Lin, Ling; Diao, Chunhong
2017-10-01
When an optical chopper is used to modulate the light source, the rotating speed of the wheel may vary with time and subsequently cause jitter of the modulation frequency. The amplitude calculated from the modulated signal would be distorted when the frequency fluctuations occur. To precisely calculate the amplitude of the modulated light flux, we proposed a method to estimate the range of the frequency fluctuation in the measurement of the spectrum and then extract the amplitude based on the sum of power of the signal in the selected frequency range. Experiments were designed to test the feasibility of the proposed method and the results showed lower root means square error than the conventional way.
Ultrasensitive detection of atmospheric trace gases using frequency modulation spectroscopy
NASA Technical Reports Server (NTRS)
Cooper, David E.
1986-01-01
Frequency modulation (FM) spectroscopy is a new technique that promises to significantly extend the state-of-the-art in point detection of atmospheric trace gases. FM spectroscopy is essentially a balanced bridge optical heterodyne approach in which a small optical absorption or dispersion from an atomic or molecular species of interest generates an easily detected radio frequency (RF) signal. This signal can be monitored using standard RF signal processing techniques and is, in principle, limited only by the shot noise generated in the photodetector by the laser source employed. The use of very high modulation frequencies which exceed the spectral width of the probed absorption line distinguishes this technique from the well-known derivative spectroscopy which makes use of low (kHz) modulation frequencies. FM spectroscopy was recently extended to the 10 micron infrared (IR) spectral region where numerous polyatomic molecules exhibit characteristic vibrational-rotational bands. In conjunction with tunable semiconductor diode lasers, the quantum-noise-limited sensitivity of the technique should allow for the detection of absorptions as small as .00000001 in the IR spectral region. This sensitivity would allow for the detection of H2O2 at concentrations as low as 1 pptv with an integration time of 10 seconds.
NASA Astrophysics Data System (ADS)
Naggary, Schabnam; Brinkmann, Ralf Peter
2015-09-01
The characteristics of radio frequency (RF) modulated plasma boundary sheaths are studied on the basis of the so-called ``standard sheath model.'' This model assumes that the applied radio frequency ωRF is larger than the plasma frequency of the ions but smaller than that of the electrons. It comprises a phase-averaged ion model - consisting of an equation of continuity (with ionization neglected) and an equation of motion (with collisional ion-neutral interaction taken into account) - a phase-resolved electron model - consisting of an equation of continuity and the assumption of Boltzmann equilibrium -, and Poisson's equation for the electrical field. Previous investigations have studied the standard sheath model under additional approximations, most notably the assumption of a step-like electron front. This contribution presents an investigation and parameter study of the standard sheath model which avoids any further assumptions. The resulting density profiles and overall charge-voltage characteristics are compared with those of the step-model based theories. The authors gratefully acknowledge Efe Kemaneci for helpful comments and fruitful discussions.
RF switching network: a novel technique for IR sensing
NASA Astrophysics Data System (ADS)
Mechtel, Deborah M.; Jenkins, R. Brian; Joyce, Peter J.; Nelson, Charles L.
2016-05-01
Rapid sensing of near infrared (IR) energy on a composite structure would provide information that could mitigate damage to composite structures. This paper describes a novel technique that implements photoconductive sensors in a radio frequency (RF) switching network designed to locate in real time the position and intensity of IR radiation incident on a composite structure. In the implementation described here, photoconductive sensors act as rapid response switches in a two layer RF network embedded in an FR-4 laminate. To detect radiation, phosphorous doped silicon photoconductive sensors are inserted in GHz range RF transmission lines. Photoconductive sensors use semiconductor materials that are optically sensitive at material dependent wavelengths. Incident radiation at the appropriate wavelength produces hole-electron pairs, so that the semiconductor becomes a conductor. By permitting signal propagation only when a sensor is illuminated, the RF signals are selectively routed from the lower layer transmission lines to the upper layer lines, thereby pinpointing the location and strength of incident radiation on a structure. Simulations based on a high frequency 3D planar electromagnetics model are presented and compared to experimental results. Experimental results are described for GHz range RF signal control for 300 mW and 180 mW incident energy from 975 nm and 1060 nm wavelength lasers respectively, where upon illumination, RF transmission line signal output power doubled when compared to non-illuminated results. Experimental results are reported for 100 W incident energy from a 1060 nm laser. Test results illustrate that real-time signal processing would permit a structure or vehicle to be controlled in response to incident radiation
NASA Astrophysics Data System (ADS)
Wang, Chaoen; Chang, Lung-Hai; Chang, Mei-Hsia; Chen, Ling-Jhen; Chung, Fu-Tsai; Lin, Ming-Chyuan; Liu, Zong-Kai; Lo, Chih-Hung; Tsai, Chi-Lin; Yeh, Meng-Shu; Yu, Tsung-Chi
2017-11-01
Excitation of multipacting, enhanced by gas condensation on cold surfaces of the high power input coupler in a SRF module poses the highest challenge for reliable SRF operation under high average RF power. This could prevent the light source SRF module from being operated with a desired high beam current. Off-line long-term reliability tests have been conducted for the newly constructed 500-MHz SRF KEKB type modules at an accelerating RF voltage of 1.6-MV to enable prediction of their operational reliability in the 3-GeV Taiwan Photon Source (TPS), since prediction from mere production performance by conventional horizontal test is presently unreliable. As expected, operational difficulties resulting from multipacting, enhanced by gas condensation, have been identified in the course of long-term reliability test. Our present hypothesis is that gas condensation can be slowed down by preserving the vacuum pressure at the power coupler close to that reached just after its cool down to liquid helium temperatures. This is achievable by reduction of the power coupler out-gassing rate through comprehensive warm aging. Its feasibility and effectiveness has been experimentally verified in a second long term reliability test. Our success opens the possibility to operate the SRF module free of multipacting trouble and opens a new direction to improve the operational performance of next generation SRF modules in light sources with high beam currents.
Re-modulated technology of WDM-PON employing different DQPSK downstream signals
NASA Astrophysics Data System (ADS)
Gao, Chao; Xin, Xiang-jun; Yu, Chong-xiu
2012-11-01
This paper proposes a kind of modulation architecture for wavelength-division-multiplexing passive optical network (WDMPON) employing optical differential quadrature phase shift keying (DQPSK) downstream signals and two different modulation formats of re-modulated upstream signals. At the optical line terminal (OLT), 10 Gbit/s signal is modulated with DQPSK. At the optical network unit (ONU), part of the downstream signal is re-modulated with on-off keying (OOK) or inverse-return-to-zero (IRZ). Simulation results show the impact on the system employing NRZ, RZ and carrier-suppressed return-to-zero (CSRZ). The analyses also reflect that the architecture can restrain chromatic dispersion and channel crosstalk, which makes it the best architecture of access network in the future.
Sabato, Alessandro; Feng, Maria Q.
2014-01-01
Recent advances in the Micro Electro-Mechanical System (MEMS) technology have made wireless MEMS accelerometers an attractive tool for Structural Health Monitoring (SHM) of civil engineering structures. To date, sensors' low sensitivity and accuracy—especially at very low frequencies—have imposed serious limitations for their application in monitoring large-sized structures. Conventionally, the MEMS sensor's analog signals are converted to digital signals before radio-frequency (RF) wireless transmission. The conversion can cause a low sensitivity to the important low-frequency and low-amplitude signals. To overcome this difficulty, the authors have developed a MEMS accelerometer system, which converts the sensor output voltage to a frequency-modulated signal before RF transmission. This is achieved by using a Voltage to Frequency Conversion (V/F) instead of the conventional Analog to Digital Conversion (ADC). In this paper, a prototype MEMS accelerometer system is presented, which consists of a transmitter and receiver circuit boards. The former is equipped with a MEMS accelerometer, a V/F converter and a wireless RF transmitter, while the latter contains an RF receiver and a F/V converter for demodulating the signal. The efficacy of the MEMS accelerometer system in measuring low-frequency and low-amplitude dynamic responses is demonstrated through extensive laboratory tests and experiments on a flow-loop pipeline. PMID:25198003
Sabato, Alessandro; Feng, Maria Q
2014-09-05
Recent advances in the Micro Electro-Mechanical System (MEMS) technology have made wireless MEMS accelerometers an attractive tool for Structural Health Monitoring (SHM) of civil engineering structures. To date, sensors' low sensitivity and accuracy--especially at very low frequencies--have imposed serious limitations for their application in monitoring large-sized structures. Conventionally, the MEMS sensor's analog signals are converted to digital signals before radio-frequency (RF) wireless transmission. The conversion can cause a low sensitivity to the important low-frequency and low-amplitude signals. To overcome this difficulty, the authors have developed a MEMS accelerometer system, which converts the sensor output voltage to a frequency-modulated signal before RF transmission. This is achieved by using a Voltage to Frequency Conversion (V/F) instead of the conventional Analog to Digital Conversion (ADC). In this paper, a prototype MEMS accelerometer system is presented, which consists of a transmitter and receiver circuit boards. The former is equipped with a MEMS accelerometer, a V/F converter and a wireless RF transmitter, while the latter contains an RF receiver and a F/V converter for demodulating the signal. The efficacy of the MEMS accelerometer system in measuring low-frequency and low-amplitude dynamic responses is demonstrated through extensive laboratory tests and experiments on a flow-loop pipeline.
Mürtz, Petra; Kaschner, Marius; Träber, Frank; Kukuk, Guido M; Büdenbender, Sarah M; Skowasch, Dirk; Gieseke, Jürgen; Schild, Hans H; Willinek, Winfried A
2012-11-01
To evaluate the use of dual-source parallel RF excitation (TX) for diffusion-weighted whole-body MRI with background body signal suppression (DWIBS) at 3.0 T. Forty consecutive patients were examined on a clinical 3.0-T MRI system using a diffusion-weighted (DW) spin-echo echo-planar imaging sequence with a combination of short TI inversion recovery and slice-selective gradient reversal fat suppression. DWIBS of the neck (n=5), thorax (n=8), abdomen (n=6) and pelvis (n=21) was performed both with TX (2:56 min) and with standard single-source RF excitation (4:37 min). The quality of DW images and reconstructed inverted maximum intensity projections was visually judged by two readers (blinded to acquisition technique). Signal homogeneity and fat suppression were scored as "improved", "equal", "worse" or "ambiguous". Moreover, the apparent diffusion coefficient (ADC) values were measured in muscles, urinary bladder, lymph nodes and lesions. By the use of TX, signal homogeneity was "improved" in 25/40 and "equal" in 15/40 cases. Fat suppression was "improved" in 17/40 and "equal" in 23/40 cases. These improvements were statistically significant (p<0.001, Wilcoxon signed-rank test). In five patients, fluid-related dielectric shading was present, which improved remarkably. The ADC values did not significantly differ for the two RF excitation methods (p=0.630 over all data, pairwise Student's t-test). Dual-source parallel RF excitation improved image quality of DWIBS at 3.0 T with respect to signal homogeneity and fat suppression, reduced scan time by approximately one-third, and did not influence the measured ADC values. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Glucagon signaling modulates sweet taste responsiveness.
Elson, Amanda E T; Dotson, Cedrick D; Egan, Josephine M; Munger, Steven D
2010-10-01
The gustatory system provides critical information about the quality and nutritional value of food before it is ingested. Thus, physiological mechanisms that modulate taste function in the context of nutritional needs or metabolic status could optimize ingestive decisions. We report that glucagon, which plays important roles in the maintenance of glucose homeostasis, enhances sweet taste responsiveness through local actions in the mouse gustatory epithelium. Using immunohistochemistry and confocal microscopy, we found that glucagon and its receptor (GlucR) are coexpressed in a subset of mouse taste receptor cells. Most of these cells also express the T1R3 taste receptor implicated in sweet and/or umami taste. Genetic or pharmacological disruption of glucagon signaling in behaving mice indicated a critical role for glucagon in the modulation of taste responsiveness. Scg5(-/-) mice, which lack mature glucagon, had significantly reduced responsiveness to sucrose as compared to wild-type littermates in brief-access taste tests. No significant differences were seen in responses to prototypical salty, sour, or bitter stimuli. Taste responsiveness to sucrose was similarly reduced upon acute and local disruption of glucagon signaling by the GlucR antagonist L-168,049. Together, these data indicate a role for local glucagon signaling in the peripheral modulation of sweet taste responsiveness.
BICMOS power detector for pulsed Rf power amplifiers
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bridge, Clayton D.
2016-10-01
A BiCMOS power detector for pulsed radio-frequency power amplifiers is proposed. Given the pulse waveform and a fraction of the power amplifier's input or output signal, the detector utilizes a low-frequency feedback loop to perform a successive approximation of the amplitude of the input signal. Upon completion of the successive approximation, the detector returns 9-bits representing the amplitude of the RF input signal. Using the pulse waveform from the power amplifier, the detector can dynamically adjust the rate of the binary search operation in order to return the updated amplitude information of the RF input signal at least every 1ms.more » The detector can handle pulse waveform frequencies from 50kHz to 10MHz with duty cycles in the range of 5- 50% and peak power levels of -10 to 10dBm. The signal amplitude measurement can be converted to a peak power measurement accurate to within ±0.6dB of the input RF power.« less
DC-based smart PV-powered home energy management system based on voltage matching and RF module
Hasan, W. Z. W.
2017-01-01
The main tool for measuring system efficiency in homes and offices is the energy monitoring of the household appliances’ consumption. With the help of GUI through a PC or smart phone, there are various applications that can be developed for energy saving. This work describes the design and prototype implementation of a wireless PV-powered home energy management system under a DC-distribution environment, which allows remote monitoring of appliances’ energy consumptions and power rate quality. The system can be managed by a central computer, which obtains the energy data based on XBee RF modules that access the sensor measurements of system components. The proposed integrated prototype framework is characterized by low power consumption due to the lack of components and consists of three layers: XBee-based circuit for processing and communication architecture, solar charge controller, and solar-battery-load matching layers. Six precise analogue channels for data monitoring are considered to cover the energy measurements. Voltage, current and temperature analogue signals were accessed directly from the remote XBee node to be sent in real time with a sampling frequency of 11–123 Hz to capture the possible surge power. The performance shows that the developed prototype proves the DC voltage matching concept and is able to provide accurate and precise results. PMID:28934271
DC-based smart PV-powered home energy management system based on voltage matching and RF module.
Sabry, Ahmad H; Hasan, W Z W; Ab Kadir, Mza; Radzi, M A M; Shafie, S
2017-01-01
The main tool for measuring system efficiency in homes and offices is the energy monitoring of the household appliances' consumption. With the help of GUI through a PC or smart phone, there are various applications that can be developed for energy saving. This work describes the design and prototype implementation of a wireless PV-powered home energy management system under a DC-distribution environment, which allows remote monitoring of appliances' energy consumptions and power rate quality. The system can be managed by a central computer, which obtains the energy data based on XBee RF modules that access the sensor measurements of system components. The proposed integrated prototype framework is characterized by low power consumption due to the lack of components and consists of three layers: XBee-based circuit for processing and communication architecture, solar charge controller, and solar-battery-load matching layers. Six precise analogue channels for data monitoring are considered to cover the energy measurements. Voltage, current and temperature analogue signals were accessed directly from the remote XBee node to be sent in real time with a sampling frequency of 11-123 Hz to capture the possible surge power. The performance shows that the developed prototype proves the DC voltage matching concept and is able to provide accurate and precise results.
10 CFR 431.222 - Definitions concerning traffic signal modules and pedestrian modules.
Code of Federal Regulations, 2013 CFR
2013-01-01
... (or hydraulic) characteristics that affect energy consumption, energy efficiency, water consumption... 10 Energy 3 2013-01-01 2013-01-01 false Definitions concerning traffic signal modules and pedestrian modules. 431.222 Section 431.222 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY...
10 CFR 431.222 - Definitions concerning traffic signal modules and pedestrian modules.
Code of Federal Regulations, 2014 CFR
2014-01-01
... (or hydraulic) characteristics that affect energy consumption, energy efficiency, water consumption... 10 Energy 3 2014-01-01 2014-01-01 false Definitions concerning traffic signal modules and pedestrian modules. 431.222 Section 431.222 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY...
10 CFR 431.222 - Definitions concerning traffic signal modules and pedestrian modules.
Code of Federal Regulations, 2012 CFR
2012-01-01
... (or hydraulic) characteristics that affect energy consumption, energy efficiency, water consumption... 10 Energy 3 2012-01-01 2012-01-01 false Definitions concerning traffic signal modules and pedestrian modules. 431.222 Section 431.222 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY...
A reprogrammable receiver architecture for wireless signal interception
NASA Astrophysics Data System (ADS)
Yao, Timothy S.
2003-09-01
In this paper, a re-programmable receiver architecture, based on software-defined-radio concept, for wireless signal interception is presented. The radio-frequency (RF) signal that the receiver would like to intercept may come from a terrestrial cellular network or communication satellites, which their carrier frequency are in the range from 800 MHz (civilian mobile) to 15 GHz (Ku band). To intercept signals from such a wide range of frequency in these variant communication systems, the traditional way is to deploy multiple receivers to scan and detect the desired signal. This traditional approach is obviously unattractive due to the cost, efficiency, and accuracy. Instead, we propose a universal receiver, which is software-driven and re-configurable, to intercept signals of interest. The software-defined-radio based receiver first intercepts RF energy of wide spectrum (25MHz) through antenna, performs zero-IF down conversion (homodyne architecture) to baseband, and digital channelizes the baseband signal. The channelization module is a bank of high performance digital filters. The bandwidth of the filter bank is programmable according to the wireless communication protocol under watch. In the baseband processing, high-performance digital signal processors carry out the detection process and microprocessors handle the communication protocols. The baseband processing is also re-configurable for different wireless standards and protocol. The advantages of the software-defined-radio architecture over traditional RF receiver make it a favorable technology for the communication signal interception and surveillance.
2001-12-01
using TeO2 , A-O cell, slow acoustic wave). Beam deflection is a continuous function of the input voltage power spectrum; however, the spot width...than for isotropic crystals. Thus, anisotropic, A-O materials, such as TeO2 , have advantages for high RF bandwidth; slow acoustic speeds give better...112 Unfortunately, signal resolution worsened because the new TeO2 crystal was designed to operate in the longitudinal acoustic mode, ua = 5.5 Km
RF pulse compression for future linear colliders
NASA Astrophysics Data System (ADS)
Wilson, Perry B.
1995-07-01
Future (nonsuperconducting) linear colliders will require very high values of peak rf power per meter of accelerating structure. The role of rf pulse compression in producing this power is examined within the context of overall rf system design for three future colliders at energies of 1.0-1.5 TeV, 5 TeV, and 25 TeV. In order to keep the average AC input power and the length of the accelerator within reasonable limits, a collider in the 1.0-1.5 TeV energy range will probably be built at an x-band rf frequency, and will require a peak power on the order of 150-200 MW per meter of accelerating structure. A 5 TeV collider at 34 GHz with a reasonable length (35 km) and AC input power (225 MW) would require about 550 MW per meter of structure. Two-beam accelerators can achieve peak powers of this order by applying dc pulse compression techniques (induction linac modules) to produce the drive beam. Klystron-driven colliders achieve high peak power by a combination of dc pulse compression (modulators) and rf pulse compression, with about the same overall rf system efficiency (30-40%) as a two-beam collider. A high gain (6.8) three-stage binary pulse compression system with high efficiency (80%) is described, which (compared to a SLED-II system) can be used to reduce the klystron peak power by about a factor of two, or alternatively, to cut the number of klystrons in half for a 1.0-1.5 TeV x-band collider. For a 5 TeV klystron-driven collider, a high gain, high efficiency rf pulse compression system is essential.
Inductively coupled wireless RF coil arrays.
Bulumulla, S B; Fiveland, E; Park, K J; Foo, T K; Hardy, C J
2015-04-01
As the number of coils increases in multi-channel MRI receiver-coil arrays, RF cables and connectors become increasingly bulky and heavy, degrading patient comfort and slowing workflow. Inductive coupling of signals provides an attractive "wireless" approach, with the potential to reduce coil weight and cost while simplifying patient setup. In this work, multi-channel inductively coupled anterior arrays were developed and characterized for 1.5T imaging. These comprised MR receiver coils inductively (or "wirelessly") linked to secondary or "sniffer" coils whose outputs were transmitted via preamps to the MR system cabinet. The induced currents in the imaging coils were blocked by passive diode circuits during RF transmit. The imaging arrays were totally passive, obviating the need to deliver power to the coils, and providing lightweight, untethered signal reception with easily positioned coils. Single-shot fast spin echo images were acquired from 5 volunteers using a 7-element inductively coupled coil array and a conventionally cabled 7-element coil array of identical geometry, with the inductively-coupled array showing a relative signal-to-noise ratio of 0.86 +/- 0.07. The concept was extended to a larger 9-element coil array to demonstrate the effect of coil element size on signal transfer and RF-transmit blocking. Copyright © 2015 Elsevier Inc. All rights reserved.
Hybrid Simulation of Duty Cycle Influences on Pulse Modulated RF SiH4/Ar Discharge
NASA Astrophysics Data System (ADS)
Wang, Xifeng; Song, Yuanhong; Zhao, Shuxia; Dai, Zhongling; Wang, Younian
2016-04-01
A one-dimensional fluid/Monte-Carlo (MC) hybrid model is developed to describe capacitively coupled SiH4/Ar discharge, in which the lower electrode is applied by a RF source and pulse modulated by a square-wave, to investigate the modulation effects of the pulse duty cycle on the discharge mechanism. An electron Monte Carlo simulation is used to calculate the electron energy distribution as a function of position and time phase. Rate coefficients in chemical reactions can then be obtained and transferred to the fluid model for the calculation of electron temperature and densities of different species, such as electrons, ions, and radicals. The simulation results show that, the electron energy distribution f(ɛ) is modulated evidently within a pulse cycle, with its tail extending to higher energies during the power-on period, while shrinking back promptly in the afterglow period. Thus, the rate coefficients could be controlled during the discharge, resulting in modulation of the species composition on the substrate compared with continuous excitation. Meanwhile, more negative ions, like SiH-3 and SiH-2, may escape to the electrodes owing to the collapse of ambipolar electric fields, which is beneficial to films deposition. Pulse modulation is thus expected to provide additional methods to customize the plasma densities and components. supported by National Natural Science Foundation of China (No. 11275038)
Using the ATL HDI 1000 to collect demodulated RF data for monitoring HIFU lesion formation
NASA Astrophysics Data System (ADS)
Anand, Ajay; Kaczkowski, Peter J.; Daigle, Ron E.; Huang, Lingyun; Paun, Marla; Beach, Kirk W.; Crum, Lawrence A.
2003-05-01
The ability to accurately track and monitor the progress of lesion formation during HIFU (High Intensity Focused Ultrasound) therapy is important for the success of HIFU-based treatment protocols. To aid in the development of algorithms for accurately targeting and monitoring formation of HIFU induced lesions, we have developed a software system to perform RF data acquisition during HIFU therapy using a commercially available clinical ultrasound scanner (ATL HDI 1000, Philips Medical Systems, Bothell, WA). The HDI 1000 scanner functions on a software dominant architecture, permitting straightforward external control of its operation and relatively easy access to quadrature demodulated RF data. A PC running a custom developed program sends control signals to the HIFU module via GPIB and to the HDI 1000 via Telnet, alternately interleaving HIFU exposures and RF frame acquisitions. The system was tested during experiments in which HIFU lesions were created in excised animal tissue. No crosstalk between the HIFU beam and the ultrasound imager was detected, thus demonstrating synchronization. Newly developed acquisition modes allow greater user control in setting the image geometry and scanline density, and enables high frame rate acquisition. This system facilitates rapid development of signal-processing based HIFU therapy monitoring algorithms and their implementation in image-guided thermal therapy systems. In addition, the HDI 1000 system can be easily customized for use with other emerging imaging modalities that require access to the RF data such as elastographic methods and new Doppler-based imaging and tissue characterization techniques.
NASA Astrophysics Data System (ADS)
Harris, J. R.; Miller, R. B.
2018-02-01
The generation and evolution of modulated particle beams and their interactions with resonant radiofrequency (RF) structures are of fundamental interest for both particle accelerator and vacuum electronic systems. When the constraint of propagation in a vacuum is removed, the evolution of such beams can be greatly affected by interactions with matter including scattering, absorption, generation of atmospheric plasma, and the production of multiple generations of secondary particles. Here, we study the propagation of 21 MeV and 25 MeV electron beams produced in S-band and L-band linear accelerators, and their interaction with resonant RF structures, under a number of combinations of geometry, including transmission through both air and metal. Both resonant and nonresonant interactions were observed, with the resonant interactions indicating that the RF modulation on the electron beam is at least partially preserved as the beam propagates through air and metal. When significant thicknesses of metal are placed upstream of a resonant structure, preventing any primary beam electrons from reaching the structure, RF signals could still be induced in the structures. This indicated that the RF modulation present on the electron beam was also impressed onto the x-rays generated when the primary electrons were stopped in the metal, and that this RF modulation was also present on the secondary electrons generated when the x-rays struck the resonant structures. The nature of these interactions and their sensitivities to changes in system configurations will be discussed.
Improved RF Measurements of SRF Cavity Quality Factors
DOE Office of Scientific and Technical Information (OSTI.GOV)
Holzbauer, J. P.; Contreras, C.; Pischalnikov, Y.
SRF cavity quality factors can be accurately measured using RF-power based techniques only when the cavity is very close to critically coupled. This limitation is from systematic errors driven by non-ideal RF components. When the cavity is not close to critically coupled, these systematic effects limit the accuracy of the measurements. The combination of the complex base-band envelopes of the cavity RF signals in combination with a trombone in the circuit allow the relative calibration of the RF signals to be extracted from the data and systematic effects to be characterized and suppressed. The improved calibration allows accurate measurements tomore » be made over a much wider range of couplings. Demonstration of these techniques during testing of a single-spoke resonator with a coupling factor of near 7 will be presented, along with recommendations for application of these techniques.« less
NASA Astrophysics Data System (ADS)
Harrell, Lee; Moore, Eric; Lee, Sanggap; Hickman, Steven; Marohn, John
2011-03-01
We present data and theoretical signal and noise calculations for a protocol using parametric amplification to evade the inherent tradeoff between signal and detector frequency noise in force-gradient magnetic resonance force microscopy signals, which are manifested as a modulated frequency shift of a high- Q microcantilever. Substrate-induced frequency noise has a 1 / f frequency dependence, while detector noise exhibits an f2 dependence on modulation frequency f . Modulation of sample spins at a frequency that minimizes these two contributions typically results in a surface frequency noise power an order of magnitude or more above the thermal limit and may prove incompatible with sample spin relaxation times as well. We show that the frequency modulated force-gradient signal can be used to excite the fundamental resonant mode of the cantilever, resulting in an audio frequency amplitude signal that is readily detected with a low-noise fiber optic interferometer. This technique allows us to modulate the force-gradient signal at a sufficiently high frequency so that substrate-induced frequency noise is evaded without subjecting the signal to the normal f2 detector noise of conventional demodulation.
Design of RF MEMS switches without pull-in instability
NASA Astrophysics Data System (ADS)
Proctor, W. Cyrus; Richards, Gregory P.; Shen, Chongyi; Skorczewski, Tyler; Wang, Min; Zhang, Jingyan; Zhong, Peng; Massad, Jordan E.; Smith, Ralph
2010-04-01
Micro-electro-mechanical systems (MEMS) switches for radio-frequency (RF) signals have certain advantages over solid-state switches, such as lower insertion loss, higher isolation, and lower static power dissipation. Mechanical dynamics can be a determining factor for the reliability of RF MEMS. The RF MEMS ohmic switch discussed in this paper consists of a plate suspended over an actuation pad by four double-cantilever springs. Closing the switch with a simple step actuation voltage typically causes the plate to rebound from its electrical contacts. The rebound interrupts the signal continuity and degrades the performance, reliability and durability of the switch. The switching dynamics are complicated by a nonlinear, electrostatic pull-in instability that causes high accelerations. Slow actuation and tailored voltage control signals can mitigate switch bouncing and effects of the pull-in instability; however, slow switching speed and overly-complex input signals can significantly penalize overall system-level performance. Examination of a balanced and optimized alternative switching solution is sought. A step toward one solution is to consider a pull-in-free switch design. In this paper, determine how simple RC-circuit drive signals and particular structural properties influence the mechanical dynamics of an RF MEMS switch designed without a pull-in instability. The approach is to develop a validated modeling capability and subsequently study switch behavior for variable drive signals and switch design parameters. In support of project development, specifiable design parameters and constraints will be provided. Moreover, transient data of RF MEMS switches from laser Doppler velocimetry will be provided for model validation tasks. Analysis showed that a RF MEMS switch could feasibly be designed with a single pulse waveform and no pull-in instability and achieve comparable results to previous waveform designs. The switch design could reliably close in a timely
Development of a dual-pulse RF driver for an S-band (= 2856 MHz) RF electron linear accelerator
NASA Astrophysics Data System (ADS)
Cha, Sungsu; Kim, Yujong; Lee, Byeong-No; Lee, Byung Cheol; Cha, Hyungki; Ha, Jang Ho; Park, Hyung Dal; Lee, Seung Hyun; Kim, Hui Su; Buaphad, Pikad
2016-04-01
The radiation equipment research division of Korea Atomic Energy Research Institute has developed a Container Inspection System (CIS) using a Radio Frequency (RF) electron linear accelerator for port security. The primary purpose of the CIS is to detect nuclear materials and explosives, as well country-specific prohibited substances, e.g., smuggled. The CIS consists of a 9/6 MeV dualenergy electron linear accelerator for distinguishing between organic and inorganic materials. The accelerator consists of an electron gun, an RF accelerating structure, an RF driver, a modulator, electromagnets, a cooling system, a X-ray generating target, X-ray collimator, a detector, and a container moving system. The RF driver is an important part of the configuration because it is the RF power source: it supplies the RF power to the accelerating structure. A unique aspect of the RF driver is that it generates dual RF power to generate dual energy (9/6 MeV). The advantage of this RF driver is that it can allow the pulse width to vary and can be used to obtain a wide range of energy output, and pulse repetition rates up to 300 Hz. For this reason, 140 W (5 MW - 9 MeV) and 37 W (3.4 MW - 6 MeV) power outputs are available independently. A high power test for 20 minutes demonstrate that stable dual output powers can be generated. Moreover, the dual power can be applied to the accelerator which has stable accelerator operation. In this paper, the design, fabrication and high power test of the RF driver for the RF electron linear accelerator (linac) are presented.
Multiband phase-modulated radio over IsOWC link with balanced coherent homodyne detection
NASA Astrophysics Data System (ADS)
Zong, Kang; Zhu, Jiang
2017-11-01
In this paper, we present a multiband phase-modulated radio over intersatellite optical wireless communication (IsOWC) link with balanced coherent homodyne detection. The proposed system can provide high linearity for transparent transport of multiband radio frequency (RF) signals and better receiver sensitivity than intensity modulated with direct detection (IM/DD) system. The exact analytical expression of signal to noise and distortion ratio (SNDR) is derived considering the third-order intermodulation product and amplifier spontaneous emission (ASE) noise. Numerical results of SNDR with various number of subchannels and modulation index are given. Results indicate that the optimal modulation index exists to maximize the SNDR. With the same system parameters, the value of the optimal modulation index will decrease with the increase of number of subchannels.
RF pulse methods for use with surface coils: Frequency-modulated pulses and parallel transmission
NASA Astrophysics Data System (ADS)
Garwood, Michael; Uğurbil, Kamil
2018-06-01
The first use of a surface coil to obtain a 31P NMR spectrum from an intact rat by Ackerman and colleagues initiated a revolution in magnetic resonance imaging (MRI) and spectroscopy (MRS). Today, we take it for granted that one can detect signals in regions external to an RF coil; at the time, however, this concept was most unusual. In the approximately four decade long period since its introduction, this simple idea gave birth to an increasing number of innovations that has led to transformative changes in the way we collect data in an in vivo magnetic resonance experiment, particularly with MRI of humans. These innovations include spatial localization and/or encoding based on the non-uniform B1 field generated by the surface coil, leading to new spectroscopic localization methods, image acceleration, and unique RF pulses that deal with B1 inhomogeneities and even reduce power deposition. Without the surface coil, many of the major technological advances that define the extraordinary success of MRI in clinical diagnosis and in biomedical research, as exemplified by projects like the Human Connectome Project, would not have been possible.
NASA Astrophysics Data System (ADS)
Gill, Douglas M.; Rasras, Mahmoud; Tu, Kun-Yii; Chen, Young-Kai; White, Alice E.; Patel, Sanjay S.; Carothers, Daniel; Pomerene, Andrew; Kamocsai, Robert; Beattie, James; Kopa, Anthony; Apsel, Alyssa; Beals, Mark; Mitchel, Jurgen; Liu, Jifeng; Kimerling, Lionel C.
2008-02-01
Integrating electronic and photonic functions onto a single silicon-based chip using techniques compatible with mass-production CMOS electronics will enable new design paradigms for existing system architectures and open new opportunities for electro-optic applications with the potential to dramatically change the management, cost, footprint, weight, and power consumption of today's communication systems. While broadband analog system applications represent a smaller volume market than that for digital data transmission, there are significant deployments of analog electro-optic systems for commercial and military applications. Broadband linear modulation is a critical building block in optical analog signal processing and also could have significant applications in digital communication systems. Recently, broadband electro-optic modulators on a silicon platform have been demonstrated based on the plasma dispersion effect. The use of the plasma dispersion effect within a CMOS compatible waveguide creates new challenges and opportunities for analog signal processing since the index and propagation loss change within the waveguide during modulation. We will review the current status of silicon-based electrooptic modulators and also linearization techniques for optical modulation.
Development and Performance Analysis of a Photonics-Assisted RF Converter for 5G Applications
NASA Astrophysics Data System (ADS)
Borges, Ramon Maia; Muniz, André Luiz Marques; Sodré Junior, Arismar Cerqueira
2017-03-01
This article presents a simple, ultra-wideband and tunable radiofrequency (RF) converter for 5G cellular networks. The proposed optoelectronic device performs broadband photonics-assisted upconversion and downconversion using a single optical modulator. Experimental results demonstrate RF conversion from DC to millimeter waves, including 28 and 38 GHz that are potential frequency bands for 5G applications. Narrow linewidth and low phase noise characteristics are observed in all generated RF carriers. An experimental digital performance analysis using different modulation schemes illustrates the applicability of the proposed photonics-based device in reconfigurable optical wireless communications.
On-chip microwave signal generation based on a silicon microring modulator.
Shao, Haifeng; Yu, Hui; Li, Xia; Li, Yan; Jiang, Jianfei; Wei, Huan; Wang, Gencheng; Dai, Tingge; Chen, Qimei; Yang, Jianyi; Jiang, Xiaoqing
2015-07-15
A photonic-assisted microwave signal generator based on a silicon microring modulator is demonstrated. The microring cavity incorporates an embedded PN junction that enables a microwave signal to modulate the lightwave circling inside. The DC component of the modulated light is trapped in the cavity, while the high-order sideband components are able to exit the cavity and then generate microwave signals at new frequencies in a photodetector. In our proof-of-concept experiment, a 10 GHz microwave signal is converted to a 20 GHz signal in the optical domain with an electrical harmonic suppression ratio of 22 dB. An analytic model is also established to explain the operation mechanism, which agrees well with the measured data.
NASA Astrophysics Data System (ADS)
Zhu, Zihang; Zhao, Shanghong; Li, Xuan; Lin, Tao; Hu, Dapeng
2018-03-01
Photonic microwave frequency down-conversion with independent multichannel phase shifting and zero-intermediate frequency (IF) receiving is proposed and demonstrated by simulation. By combined use of a phase modulator (PM) in a sagnac loop and an optical bandpass filter (OBPF), orthogonal polarized carrier suppression single sideband (CS-SSB) signals are obtained. By adjusting the polarization controllers (PCs) to introduce the phase difference in the optical domain and using balanced detection to eliminate the direct current components, the phase of the generated IF signal can be arbitrarily tuned. Besides, the radio frequency (RF) vector signal can be also frequency down-converted to baseband directly by choosing two quadrature channels. In the simulation, high gain and continuously tunable phase shifts over the 360 degree range are verified. Furthermore, 2.5 Gbit/s RF vector signals centered at 10 GHz with different modulation formats are successfully demodulated.
Dichrometer errors resulting from large signals or improper modulator phasing.
Sutherland, John C
2012-09-01
A single-beam spectrometer equipped with a photoelastic modulator can be configured to measure a number of different parameters useful in characterizing chemical and biochemical materials including natural and magnetic circular dichroism, linear dichroism, natural and magnetic fluorescence-detected circular dichroism, and fluorescence polarization anisotropy as well as total absorption and fluorescence. The derivations of the mathematical expressions used to extract these parameters from ultraviolet, visible, and near-infrared light-induced electronic signals in a dichrometer assume that the dichroic signals are sufficiently small that certain mathematical approximations will not introduce significant errors. This article quantifies errors resulting from these assumptions as a function of the magnitude of the dichroic signals. In the case of linear dichroism, improper modulator programming can result in errors greater than those resulting from the assumption of small signal size, whereas for fluorescence polarization anisotropy, improper modulator phase alone gives incorrect results. Modulator phase can also impact the values of total absorbance recorded simultaneously with linear dichroism and total fluorescence. Copyright © 2012 Wiley Periodicals, Inc., A Wiley Company.
Space Shuttle communications RF switch matrix
NASA Technical Reports Server (NTRS)
Winch, R.
1979-01-01
The Shuttle Orbiter communications equipment includes phase modulation (PM) and frequency modulation (FM) channels. The PM section has the capability of routing high levels of energy (175 W) from any one of four transmitters to any one of four antennas, mutually exclusive. The FM channel uses a maximum of 15-W power routed from either of two transmitters to one of two antennas, mutually exclusive. The paper describes the design and the theory of a logic-controlled RF switch matrix devised for the purposes cited. Both PM and FM channels are computer-controlled with manual overrides. The logic interface is realized with CMOS logic for low power consumption and high noise immunity. The interior of the switch matrix is maintained at a pressure of 15 psi (90% nitrogen, 10% helium) by an electron beam-welded encapsulation. The computational results confirm the viability of the RF switch matrix concept.
Development of new S-band RF window for stable high-power operation in linear accelerator RF system
NASA Astrophysics Data System (ADS)
Joo, Youngdo; Lee, Byung-Joon; Kim, Seung-Hwan; Kong, Hyung-Sup; Hwang, Woonha; Roh, Sungjoo; Ryu, Jiwan
2017-09-01
For stable high-power operation, a new RF window is developed in the S-band linear accelerator (Linac) RF systems of the Pohang Light Source-II (PLS-II) and the Pohang Accelerator Laboratory X-ray Free-Electron Laser (PAL-XFEL). The new RF window is designed to mitigate the strength of the electric field at the ceramic disk and also at the waveguide-cavity coupling structure of the conventional RF window. By replacing the pill-box type cavity in the conventional RF window with an overmoded cavity, the electric field component perpendicular to the ceramic disk that caused most of the multipacting breakdowns in the ceramic disk was reduced by an order of magnitude. The reduced electric field at the ceramic disk eliminated the Ti-N coating process on the ceramic surface in the fabrication procedure of the new RF window, preventing the incomplete coating from spoiling the RF transmission and lowering the fabrication cost. The overmoded cavity was coupled with input and output waveguides through dual side-wall coupling irises to reduce the electric field strength at the waveguide-cavity coupling structure and the possibility of mode competitions in the overmoded cavity. A prototype of the new RF window was fabricated and fully tested with the Klystron peak input power, pulse duration and pulse repetition rate of 75 MW, 4.5 μs and 10 Hz, respectively, at the high-power test stand. The first mass-produced new RF window installed in the PLS-II Linac is running in normal operation mode. No fault is reported to date. Plans are being made to install the new RF window to all S-band accelerator RF modules of the PLS-II and PAL-XFEL Linacs. This new RF window may be applied to the output windows of S-band power sources like Klystron as wells as the waveguide windows of accelerator facilities which operate in S-band.
Cell oxidation-reduction imbalance after modulated radiofrequency radiation.
Marjanovic, Ana Marija; Pavicic, Ivan; Trosic, Ivancica
2015-01-01
Aim of this study was to evaluate an influence of modulated radiofrequency field (RF) of 1800 MHz, strength of 30 V/m on oxidation-reduction processes within the cell. The assigned RF field was generated within Gigahertz Transversal Electromagnetic Mode cell equipped by signal generator, modulator, and amplifier. Cell line V79, was irradiated for 10, 30, and 60 min, specific absorption rate was calculated to be 1.6 W/kg. Cell metabolic activity and viability was determined by MTT assay. In order to define total protein content, colorimetric method was used. Concentration of oxidised proteins was evaluated by enzyme-linked immunosorbent assay. Reactive oxygen species (ROS) marked with fluorescent probe 2',7'-dichlorofluorescin diacetate were measured by means of plate reader device. In comparison with control cell samples, metabolic activity and total protein content in exposed cells did not differ significantly. Concentrations of carbonyl derivates, a product of protein oxidation, insignificantly but continuously increase with duration of exposure. In exposed samples, ROS level significantly (p < 0.05) increased after 10 min of exposure. Decrease in ROS level was observed after 30-min treatment indicating antioxidant defence mechanism activation. In conclusion, under the given laboratory conditions, modulated RF radiation might cause impairment in cell oxidation-reduction equilibrium within the growing cells.
Studies on omnidirectional enhancement of giga-hertz radiation by sub-wavelength plasma modulation
NASA Astrophysics Data System (ADS)
Fanrong, KONG; Qiuyue, NIE; Shu, LIN; Zhibin, WANG; Bowen, LI; Shulei, ZHENG; Binhao, JIANG
2018-01-01
The technology of radio frequency (RF) radiation intensification for radio compact antennas based on modulation and enhancement effects of sub-wavelength plasma structures represents an innovative developing strategy. It exhibits important scientific significance and promising potential of broad applications in various areas of national strategic demands, such as electrical information network and microwave communication, detection and control technology. In this paper, laboratory experiments and corresponding analyses have been carried out to investigate the modulation and enhancement technology of sub-wavelength plasma structure on the RF electromagnetic radiation. An application focused sub-wavelength plasma-added intensification up to ∼7 dB higher than the free-space radiation is observed experimentally in giga-hertz (GHz) RF band. The effective radiation enhancement bandwidth covers from 0.85 to 1.17 GHz, while the enhanced electromagnetic signals transmitted by sub-wavelength plasma structures maintain good communication quality. Particularly, differing from the traditional RF electromagnetic radiation enhancement method characterized by focusing the radiation field of antenna in a specific direction, the sub-wavelength plasma-added intensification of the antenna radiation presents an omnidirectional enhancement, which is reported experimentally for the first time. Corresponding performance characteristics and enhancement mechanism analyses are also conducted in this paper. The results have demonstrated the feasibility and promising potential of sub-wavelength plasma modulation in application focused RF communication, and provided the scientific basis for further research and development of sub-wavelength plasma enhanced compact antennas with wide-range requests and good quality for communication.
Adaptive Nonlinear RF Cancellation for Improved Isolation in Simultaneous Transmit–Receive Systems
NASA Astrophysics Data System (ADS)
Kiayani, Adnan; Waheed, Muhammad Zeeshan; Anttila, Lauri; Abdelaziz, Mahmoud; Korpi, Dani; Syrjala, Ville; Kosunen, Marko; Stadius, Kari; Ryynanen, Jussi; Valkama, Mikko
2018-05-01
This paper proposes an active radio frequency (RF) cancellation solution to suppress the transmitter (TX) passband leakage signal in radio transceivers supporting simultaneous transmission and reception. The proposed technique is based on creating an opposite-phase baseband equivalent replica of the TX leakage signal in the transceiver digital front-end through adaptive nonlinear filtering of the known transmit data, to facilitate highly accurate cancellation under a nonlinear TX power amplifier (PA). The active RF cancellation is then accomplished by employing an auxiliary transmitter chain, to generate the actual RF cancellation signal, and combining it with the received signal at the receiver (RX) low noise amplifier (LNA) input. A closed-loop parameter learning approach, based on the decorrelation principle, is also developed to efficiently estimate the coefficients of the nonlinear cancellation filter in the presence of a nonlinear TX PA with memory, finite passive isolation, and a nonlinear RX LNA. The performance of the proposed cancellation technique is evaluated through comprehensive RF measurements adopting commercial LTE-Advanced transceiver hardware components. The results show that the proposed technique can provide an additional suppression of up to 54 dB for the TX passband leakage signal at the RX LNA input, even at considerably high transmit power levels and with wide transmission bandwidths. Such novel cancellation solution can therefore substantially improve the TX-RX isolation, hence reducing the requirements on passive isolation and RF component linearity, as well as increasing the efficiency and flexibility of the RF spectrum use in the emerging 5G radio networks.
Wnt signal transduction pathways: modules, development and evolution.
Nayak, Losiana; Bhattacharyya, Nitai P; De, Rajat K
2016-08-01
Wnt signal transduction pathway (Wnt STP) is a crucial intracellular pathway mainly due to its participation in important biological processes, functions, and diseases, i.e., embryonic development, stem-cell management, and human cancers among others. This is why Wnt STP is one of the highest researched signal transduction pathways. Study and analysis of its origin, expansion and gradual development to the present state as found in humans is one aspect of Wnt research. The pattern of development and evolution of the Wnt STP among various species is not clear till date. A phylogenetic tree created from Wnt STPs of multiple species may address this issue. In this respect, we construct a phylogenetic tree from modules of Wnt STPs of diverse species. We term it as the 'Module Tree'. A module is nothing but a self-sufficient minimally-dependent subset of the original Wnt STP. Authenticity of the module tree is tested by comparing it with the two reference trees. The module tree performs better than an alternative phylogenetic tree constructed from pathway topology of Wnt STPs. Moreover, an evolutionary emergence pattern of the Wnt gene family is created and the module tree is tallied with it to showcase the significant resemblances.
Analysis of interference of QPSK and QDPSK modulation signals by mathematical
NASA Astrophysics Data System (ADS)
Li, Dairuo; Xu, Kai
2017-03-01
In today's society, with the rapid development and extensive application of the information technology of the network central station and the integrated information system technology, information plays an important role in the military communication, mastering the information right to the competition Important role, how to protect one's own security, smooth access to and transmission of information, and to maximize the elimination of interference has become an important issue at home and abroad. QPSK modulation and its improved QPSK modulation as the mainstream signal modulation, the most widely used. In this paper, the principle of QPSK and QDPSK modulation and demodulation are introduced in this paper. Then, how to interfere with QPSK modulation signal is analyzed, and the interference of QPSK modulation signal is simulated by Matlab scripting program, which can be used in the next step. And to study the next step of anti-jamming measures provided the basis and preparatory work.
Probiotic Modulation of Innate Cell Pathogen Sensing and Signaling Events
Llewellyn, Amy; Foey, Andrew
2017-01-01
There is a growing body of evidence documenting probiotic bacteria to have a beneficial effect to the host through their ability to modulate the mucosal immune system. Many probiotic bacteria can be considered to act as either immune activators or immune suppressors, which have appreciable influence on homeostasis, inflammatory- and suppressive-immunopathology. What is becoming apparent is the ability of these probiotics to modulate innate immune responses via direct or indirect effects on the signaling pathways that drive these activatory or suppressive/tolerogenic mechanisms. This review will focus on the immunomodulatory role of probiotics on signaling pathways in innate immune cells: from positive to negative regulation associated with innate immune cells driving gut mucosal functionality. Research investigations have shown probiotics to modulate innate functionality in many ways including, receptor antagonism, receptor expression, binding to and expression of adaptor proteins, expression of negative regulatory signal molecules, induction of micro-RNAs, endotoxin tolerisation and finally, the secretion of immunomodulatory proteins, lipids and metabolites. The detailed understanding of the immunomodulatory signaling effects of probiotic strains will facilitate strain-specific selective manipulation of innate cell signal mechanisms in the modulation of mucosal adjuvanticity, immune deviation and tolerisation in both healthy subjects and patients with inflammatory and suppressive pathology. PMID:29065562
An RF energy harvesting power management circuit for appropriate duty-cycled operation
NASA Astrophysics Data System (ADS)
Shirane, Atsushi; Ito, Hiroyuki; Ishihara, Noboru; Masu, Kazuya
2015-04-01
In this study, we present an RF energy harvesting power management unit (PMU) for battery-less wireless sensor devices (WSDs). The proposed PMU realizes a duty-cycled operation that is divided into the energy charging time and discharging time. The proposed PMU detects two types of timing, thus, the appropriate timing for the activation can be recognized. The activation of WSDs at the proper timing leads to energy efficient operation and stable wireless communication. The proposed PMU includes a hysteresis comparator (H-CMP) and an RF signal detector (RF-SD) to detect the timings. The proposed RF-SD can operate without the degradation of charge efficiency by reusing the RF energy harvester (RF-EH) and H-CMP. The PMU fabricated in a 180 nm Si CMOS demonstrated the charge operation using the RF signal at 915 MHz and the two types of timing detection with less than 124 nW in the charge phase. Furthermore, in the active phase, the PMU generates a 0.5 V regulated power supply from the charged energy.
Blind Equalization and Fading Channel Signal Recovery of OFDM Modulation
2011-03-01
Square LTI Linear Time Invariant MIMO Multiple-Input Multiple-Output OFDM Orthogonal Frequency-Division Multiplexing QPSK Quadrature Phase-Shift...AND FADING CHANNEL SIGNAL RECOVERY OF OFDM MODULATION by Anthony G. Stranges March 2011 Thesis Co-Advisors: Roberto Cristi Frank Kragh...Master’s Thesis 4. TITLE AND SUBTITLE Blind Equalization and Fading Channel Signal Recovery of OFDM Modulation 6. AUTHOR(S) Anthony G. Stranges
DOE Office of Scientific and Technical Information (OSTI.GOV)
Huo, W. G.; Li, R. M.; Shi, J. J.
The overshoot and undershoot of the applied voltage on the electrodes, the discharge current, and radio frequency (RF) power were observed at the initial phase of pulse-modulated (PM) RF atmospheric pressure discharges, but factors influencing the overshoot and undershoot have not been fully elucidated. In this paper, the experimental studies were performed to seek the reasons for the overshoot and undershoot. The experimental results show that the overshoot and undershoot are associated with the pulse frequency, the rise time of pulse signal, and the series capacitor C{sub s} in the inversely L-shaped matching network. In the case of a highmore » RF power discharge, these overshoot and undershoot become serious when shortening the rise time of a pulse signal (5 ns) or operating at a moderate pulse frequency (500 Hz or 1 kHz).« less
Modulation of neuronal responses during covert search for visual feature conjunctions
Buracas, Giedrius T.; Albright, Thomas D.
2009-01-01
While searching for an object in a visual scene, an observer's attentional focus and eye movements are often guided by information about object features and spatial locations. Both spatial and feature-specific attention are known to modulate neuronal responses in visual cortex, but little is known of the dynamics and interplay of these mechanisms as visual search progresses. To address this issue, we recorded from directionally selective cells in visual area MT of monkeys trained to covertly search for targets defined by a unique conjunction of color and motion features and to signal target detection with an eye movement to the putative target. Two patterns of response modulation were observed. One pattern consisted of enhanced responses to targets presented in the receptive field (RF). These modulations occurred at the end-stage of search and were more potent during correct target identification than during erroneous saccades to a distractor in RF, thus suggesting that this modulation is not a mere presaccadic enhancement. A second pattern of modulation was observed when RF stimuli were nontargets that shared a feature with the target. The latter effect was observed during early stages of search and is consistent with a global feature-specific mechanism. This effect often terminated before target identification, thus suggesting that it interacts with spatial attention. This modulation was exhibited not only for motion but also for color cue, although MT neurons are known to be insensitive to color. Such cue-invariant attentional effects may contribute to a feature binding mechanism acting across visual dimensions. PMID:19805385
Modulation of neuronal responses during covert search for visual feature conjunctions.
Buracas, Giedrius T; Albright, Thomas D
2009-09-29
While searching for an object in a visual scene, an observer's attentional focus and eye movements are often guided by information about object features and spatial locations. Both spatial and feature-specific attention are known to modulate neuronal responses in visual cortex, but little is known of the dynamics and interplay of these mechanisms as visual search progresses. To address this issue, we recorded from directionally selective cells in visual area MT of monkeys trained to covertly search for targets defined by a unique conjunction of color and motion features and to signal target detection with an eye movement to the putative target. Two patterns of response modulation were observed. One pattern consisted of enhanced responses to targets presented in the receptive field (RF). These modulations occurred at the end-stage of search and were more potent during correct target identification than during erroneous saccades to a distractor in RF, thus suggesting that this modulation is not a mere presaccadic enhancement. A second pattern of modulation was observed when RF stimuli were nontargets that shared a feature with the target. The latter effect was observed during early stages of search and is consistent with a global feature-specific mechanism. This effect often terminated before target identification, thus suggesting that it interacts with spatial attention. This modulation was exhibited not only for motion but also for color cue, although MT neurons are known to be insensitive to color. Such cue-invariant attentional effects may contribute to a feature binding mechanism acting across visual dimensions.
Intracellular Signal Modulation by Nanomaterials
Hussain, Salik; Garantziotis, Stavros; Rodrigues-Lima, Fernando; Dupret, Jean-Marie; Baeza-Squiban, Armelle; Boland, Sonja
2016-01-01
A thorough understanding of the interactions of nanomaterials with biological systems and the resulting activation of signal transduction pathways is essential for the development of safe and consumer friendly nanotechnology. Here we present an overview of signaling pathways induced by nanomaterial exposures and describe the possible correlation of their physicochemical characteristics with biological outcomes. In addition to the hierarchical oxidative stress model and a review of the intrinsic and cell-mediated mechanisms of reactive Oxygen species (ROS) generating capacities of nanomaterials, we also discuss other oxidative stress dependent and independent cellular signaling pathways. Induction of the inflammasome, calcium signaling, and endoplasmic reticulum stress are reviewed. Furthermore, the uptake mechanisms can crucially affect the cytotoxicity of nanomaterials and membrane-dependent signaling pathways can be responsible for cellular effects of nanomaterials. Epigenetic regulation by nanomaterials effects of nanoparticle-protein interactions on cell signaling pathways, and the induction of various cell death modalities by nanomaterials are described. We describe the common trigger mechanisms shared by various nanomaterials to induce cell death pathways and describe the interplay of different modalities in orchestrating the final outcome after nanomaterial exposures. A better understanding of signal modulations induced by nanomaterials is not only essential for the synthesis and design of safer nanomaterials but will also help to discover potential nanomedical applications of these materials. Several biomedical applications based on the different signaling pathways induced by nanomaterials are already proposed and will certainly gain a great deal of attraction in the near future. PMID:24683030
Lee, Seung-Hun; Kim, Hyoung-Jun; Song, Jong-In
2014-01-13
A broadband photonic single sideband (SSB) frequency up-converter based on the cross polarization modulation (XPolM) effect in a semiconductor optical amplifier (SOA) is proposed and experimentally demonstrated. An optical radio frequency (RF) signal in the form of an optical single sideband (OSSB) is generated by the photonic SSB frequency up-converter to solve the power fading problem caused by fiber chromatic dispersion. The generated OSSB RF signal has almost identical optical carrier power and optical sideband power. This SSB frequency up-conversion scheme shows an almost flat electrical RF power response as a function of the RF frequency in a range from 31 GHz to 75 GHz after 40 km single mode fiber (SMF) transmission. The photonic SSB frequency up-conversion technique shows negligible phase noise degradation. The phase noise of the up-converted RF signal at 49 GHz for an offset of 10 kHz is -93.17 dBc/Hz. Linearity analysis shows that the photonic SSB frequency up-converter has a spurious free dynamic range (SFDR) value of 79.51 dB · Hz(2/3).
NASA Astrophysics Data System (ADS)
Wang, Yunxin; Li, Jingnan; Wang, Dayong; Zhou, Tao; Xu, Jiahao; Zhong, Xin; Yang, Dengcai; Rong, Lu
2018-03-01
An ultra-wideband microwave photonic frequency downconverter is proposed based on carrier-suppressed single-sideband (CS-SSB) modulation. A radio frequency (RF) signal and a local oscillator (LO) signal are combined to drive a dual-parallel Mach-Zehnder modulator (DPMZM) through the electrical 90°hybrid coupler. To break through the bandwidth limit, an optical bandpass filter (OBPF) is applied simultaneously. Then a photodetector (PD) after OBPF is used to obtain intermediate frequency (IF) signal. Experimental results demonstrate that the proposed frequency downconverter can generate the CS-SSB modulation signal from 2 to 40 GHz in optical spectrum. All the mixing spurs are completely suppressed under the noise floor in electrical spectrum, and the output IF signal possesses high purity with a suppression ratio of the undesired signals (≥40 dB). Furthermore, the multi-octave downconversion can also be implemented to satisfy the bandwidth requirement of multi-channel communication. The proposed frequency downconverter supplies an ultra-wideband and high-purity alternative for the signal processing in microwave photonic applications.
Cytokine Signaling Modulates Blood-Brain Barrier Function
Pan, Weihong; Stone, Kirsten P.; Hsuchou, Hung; Manda, Vamshi K.; Zhang, Yan; Kastin, Abba J.
2014-01-01
The blood-brain barrier (BBB) provides a vast interface for cytokines to affect CNS function. The BBB is a target for therapeutic intervention. It is essential, therefore, to understand how cytokines interact with each other at the level of the BBB and how secondary signals modulate CNS functions beyond the BBB. The interactions between cytokines and lipids, however, have not been fully addressed at the level of the BBB. Here, we summarize current understanding of the localization of cytokine receptors and transporters in specific membrane microdomains, particularly lipid rafts, on the luminal (apical) surface of the microvascular endothelial cells composing the BBB. We then illustrate the clinical context of cytokine effects on the BBB by neuroendocrine regulation and amplification of inflammatory signals. Two unusual aspects discussed are signaling crosstalk by different classes of cytokines and genetic regulation of drug efflux transporters. We also introduce a novel area of focus on how cytokines may act through nuclear hormone receptors to modulate efflux transporters and other targets. A specific example discussed is the ATP-binding cassette transporter-1 (ABCA-1) that regulates lipid metabolism. Overall, cytokine signaling at the level of the BBB is a crucial feature of the dynamic regulation that can rapidly change BBB function and affect brain health and disease. PMID:21834767
The effect of interference on delta modulation encoded video signals
NASA Technical Reports Server (NTRS)
Schilling, D. L.
1979-01-01
The results of a study on the use of the delta modulator as a digital encoder of television signals are presented. The computer simulation was studied of different delta modulators in order to find a satisfactory delta modulator. After finding a suitable delta modulator algorithm via computer simulation, the results are analyzed and then implemented in hardware to study the ability to encode real time motion pictures from an NTSC format television camera. The effects were investigated of channel errors on the delta modulated video signal and several error correction algorithms were tested via computer simulation. A very high speed delta modulator was built (out of ECL logic), incorporating the most promising of the correction schemes, so that it could be tested on real time motion pictures. The final area of investigation concerned itself with finding delta modulators which could achieve significant bandwidth reduction without regard to complexity or speed. The first such scheme to be investigated was a real time frame to frame encoding scheme which required the assembly of fourteen, 131,000 bit long shift registers as well as a high speed delta modulator. The other schemes involved two dimensional delta modulator algorithms.
Zhuang, Leimeng; Taddei, Caterina; Hoekman, Marcel; Leinse, Arne; Heideman, René; van Dijk, Paulus; Roeloffzen, Chris
2013-11-04
In this paper, we propose and experimentally demonstrate a novel wideband on-chip photonic modulation transformer for phase-modulated microwave photonic links. The proposed device is able to transform phase-modulated optical signals into intensity-modulated versions (or vice versa) with nearly zero conversion of laser phase noise to intensity noise. It is constructed using waveguide-based ring resonators, which features simple architecture, stable operation, and easy reconfigurability. Beyond the stand-alone functionality, the proposed device can also be integrated with other functional building blocks of photonic integrated circuits (PICs) to create on-chip complex microwave photonic signal processors. As an application example, a PIC consisting of two such modulation transformers and a notch filter has been designed and realized in TriPleX(TM) waveguide technology. The realized device uses a 2 × 2 splitting circuit and 3 ring resonators with a free spectral range of 25 GHz, which are all equipped with continuous tuning elements. The device can perform phase-to-intensity modulation transform and carrier suppression simultaneously, which enables high-performance phase-modulated microwave photonics links (PM-MPLs). Associated with the bias-free and low-complexity advantages of the phase modulators, a single-fiber-span PM-MPL with a RF bandwidth of 12 GHz (3 dB-suppression band 6 to 18 GHz) has been demonstrated comprising the proposed PIC, where the achieved spurious-free dynamic range performance is comparable to that of Class-AB MPLs using low-biased Mach-Zehnder modulators.
Optical signal monitoring in phase modulated optical fiber transmission systems
NASA Astrophysics Data System (ADS)
Zhao, Jian
Optical performance monitoring (OPM) is one of the essential functions for future high speed optical networks. Among the parameters to be monitored, chromatic dispersion (CD) is especially important since it has a significant impact on overall system performance. In this thesis effective CD monitoring approaches for phase-shift keying (PSK) based optical transmission systems are investigated. A number of monitoring schemes based on radio frequency (RF) spectrum analysis and delay-tap sampling are proposed and their performance evaluated. A method for dispersion monitoring of differential phase-shift keying (DPSK) signals based on RF power detection is studied. The RF power spectrum is found to increase with the increase of CD and decrease with polarization mode dispersion (PMD). The spectral power density dependence on CD is studied theoretically and then verified through simulations and experiments. The monitoring sensitivity for nonreturn-to-zero differential phase-shift keying (NRZ-DPSK) and return-to-zero differential phase-shift keying (RZ-DPSK) based systems can reach 80ps/nm/dB and 34ps/nm/dB respectively. The scheme enables the monitoring of differential group delay (DGD) and CD simultaneously. The monitoring sensitivity of CD and DGD can reach 56.7ps/nm/dB and 3.1ps/dB using a bandpass filter. The effects of optical signal-to-noise ratio (OSNR), DGD, fiber nonlinearity and chirp on the monitoring results are investigated. Two RF pilot tones are employed for CD monitoring of DPSK signals. Specially selected pilot tone frequencies enable good monitoring sensitivity with minimum influence on the received signals. The dynamic range exceeding 35dB and monitoring sensitivity up to 9.5ps/nm/dB are achieved. Asynchronous sampling technique is employed for CD monitoring. A signed CD monitoring method for 10Gb/s NRZ-DPSK and RZ-DPSK systems using asynchronous delay-tap sampling technique is studied. The demodulated signals suffer asymmetric waveform distortion if
Detecting modulated signals in modulated noise: (II) neural thresholds in the songbird forebrain.
Bee, Mark A; Buschermöhle, Michael; Klump, Georg M
2007-10-01
Sounds in the real world fluctuate in amplitude. The vertebrate auditory system exploits patterns of amplitude fluctuations to improve signal detection in noise. One experimental paradigm demonstrating these general effects has been used in psychophysical studies of 'comodulation detection difference' (CDD). The CDD effect refers to the fact that thresholds for detecting a modulated, narrowband noise signal are lower when the envelopes of flanking bands of modulated noise are comodulated with each other, but fluctuate independently of the signal compared with conditions in which the envelopes of the signal and flanking bands are all comodulated. Here, we report results from a study of the neural correlates of CDD in European starlings (Sturnus vulgaris). We manipulated: (i) the envelope correlations between a narrowband noise signal and a masker comprised of six flanking bands of noise; (ii) the signal onset delay relative to masker onset; (iii) signal duration; and (iv) masker spectrum level. Masked detection thresholds were determined from neural responses using signal detection theory. Across conditions, the magnitude of neural CDD ranged between 2 and 8 dB, which is similar to that reported in a companion psychophysical study of starlings [U. Langemann & G.M. Klump (2007) Eur. J. Neurosci., 26, 1969-1978]. We found little evidence to suggest that neural CDD resulted from the across-channel processing of auditory grouping cues related to common envelope fluctuations and synchronous onsets between the signal and flanking bands. We discuss a within-channel model of peripheral processing that explains many of our results.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Li, D.; Bowring, D.; DeMello, A.
2012-05-20
Recent progress on the design and fabrication of the RFCC (RF and superconducting Coupling Coil) module for the international MICE (Muon Ionization Cooling Experiment) are reported. The MICE ionization cooling channel has two RFCC modules, each having four 201- MHz normal conducting RF cavities surrounded by one superconducting coupling coil (solenoid) magnet. The magnet is designed to be cooled by three cryocoolers. Fabrication of the RF cavities is complete; preparation for the cavity electro-polishing, low power RF measurements, and tuning are in progress at Lawrence Berkeley National Laboratory (LBNL). Fabrication of the cold mass of the first coupling coil magnetmore » has been completed in China and the cold mass arrived at LBNL in late 2011. Preparations for testing the cold mass are currently under way at Fermilab. Plans for the RFCC module assembly and integration are being developed and are described.« less
The 30-GHz monolithic receive module
NASA Technical Reports Server (NTRS)
Sokolov, V.; Geddes, J.; Bauhahn, P.
1983-01-01
Key requirements for a 30 GHz GaAs monolithic receive module for spaceborne communication antenna feed array applications include an overall receive module noise figure of 5 dB, a 30 dB RF to IF gain with six levels of intermediate gain control, a five-bit phase shifter, and a maximum power consumption of 250 mW. The RF designs for each of the four submodules (low noise amplifier, some gain control, phase shifter, and RF to IF sub-module) are presented. Except for the phase shifter, high frequency, low noise FETs with sub-half micron gate lengths are employed in the submodules. For the gain control, a two stage dual gate FET amplifier is used. The phase shifter is of the passive switched line type and consists of 5-bits. It uses relatively large gate width FETs (with zero drain to source bias) as the switching elements. A 20 GHz local oscillator buffer amplifier, a FET compatible balanced mixer, and a 5-8 GHz IF amplifier constitute the RF/IF sub-module. Phase shifter fabrication using ion implantation and a self-aligned gate technique is described. Preliminary RF results obtained on such phase shifters are included.
NASA Astrophysics Data System (ADS)
Xie, Yiwei; Geng, Zihan; Zhuang, Leimeng; Burla, Maurizio; Taddei, Caterina; Hoekman, Marcel; Leinse, Arne; Roeloffzen, Chris G. H.; Boller, Klaus-J.; Lowery, Arthur J.
2017-12-01
Integrated optical signal processors have been identified as a powerful engine for optical processing of microwave signals. They enable wideband and stable signal processing operations on miniaturized chips with ultimate control precision. As a promising application, such processors enables photonic implementations of reconfigurable radio frequency (RF) filters with wide design flexibility, large bandwidth, and high-frequency selectivity. This is a key technology for photonic-assisted RF front ends that opens a path to overcoming the bandwidth limitation of current digital electronics. Here, the recent progress of integrated optical signal processors for implementing such RF filters is reviewed. We highlight the use of a low-loss, high-index-contrast stoichiometric silicon nitride waveguide which promises to serve as a practical material platform for realizing high-performance optical signal processors and points toward photonic RF filters with digital signal processing (DSP)-level flexibility, hundreds-GHz bandwidth, MHz-band frequency selectivity, and full system integration on a chip scale.
Lu, Hai-Han; Li, Chung-Yi; Chen, Hwan-Wei; Ho, Chun-Ming; Cheng, Ming-Te; Huang, Sheng-Jhe; Yang, Zih-Yi; Lin, Xin-Yao
2016-07-25
A bidirectional fiber-wireless and fiber-invisible laser light communication (IVLLC) integrated system that employs polarization-orthogonal modulation scheme for hybrid cable television (CATV)/microwave (MW)/millimeter-wave (MMW)/baseband (BB) signal transmission is proposed and demonstrated. To our knowledge, it is the first one that adopts a polarization-orthogonal modulation scheme in a bidirectional fiber-wireless and fiber-IVLLC integrated system with hybrid CATV/MW/MMW/BB signal. For downlink transmission, carrier-to-noise ratio (CNR), composite second-order (CSO), composite triple-beat (CTB), and bit error rate (BER) perform well over 40-km single-mode fiber (SMF) and 10-m RF/50-m optical wireless transport scenarios. For uplink transmission, good BER performance is obtained over 40-km SMF and 50-m optical wireless transport scenario. Such a bidirectional fiber-wireless and fiber-IVLLC integrated system for hybrid CATV/MW/MMW/BB signal transmission will be an attractive alternative for providing broadband integrated services, including CATV, Internet, and telecommunication services. It is shown to be a prominent one to present the advancements for the convergence of fiber backbone and RF/optical wireless feeder.
Intracellular signal modulation by nanomaterials.
Hussain, Salik; Garantziotis, Stavros; Rodrigues-Lima, Fernando; Dupret, Jean-Marie; Baeza-Squiban, Armelle; Boland, Sonja
2014-01-01
A thorough understanding of the interactions of nanomaterials with biological systems and the resulting activation of signal transduction pathways is essential for the development of safe and consumer friendly nanotechnology. Here we present an overview of signaling pathways induced by nanomaterial exposures and describe the possible correlation of their physicochemical characteristics with biological outcomes. In addition to the hierarchical oxidative stress model and a review of the intrinsic and cell-mediated mechanisms of reactive oxygen species (ROS) generating capacities of nanomaterials, we also discuss other oxidative stress dependent and independent cellular signaling pathways. Induction of the inflammasome, calcium signaling, and endoplasmic reticulum stress are reviewed. Furthermore, the uptake mechanisms can be of crucial importance for the cytotoxicity of nanomaterials and membrane-dependent signaling pathways have also been shown to be responsible for cellular effects of nanomaterials. Epigenetic regulation by nanomaterials, effects of nanoparticle-protein interactions on cell signaling pathways, and the induction of various cell death modalities by nanomaterials are described. We describe the common trigger mechanisms shared by various nanomaterials to induce cell death pathways and describe the interplay of different modalities in orchestrating the final outcome after nanomaterial exposures. A better understanding of signal modulations induced by nanomaterials is not only essential for the synthesis and design of safer nanomaterials but will also help to discover potential nanomedical applications of these materials. Several biomedical applications based on the different signaling pathways induced by nanomaterials are already proposed and will certainly gain a great deal of attraction in the near future.
Improved RF Isolation Amplifier
NASA Technical Reports Server (NTRS)
Stevens, G. L.; Macconnell, J.
1985-01-01
Circuit has high reverse isolation and wide bandwidth. Wideband isolation amplifier has low intermodulation distortion and high reverse isolation. Circuit does not require selected or matched components or directional coupling device. Circuit used in applications requiring high reverse isolation such as receiver intermediate-frequency (IF) strips and frequency distribution systems. Also applicable in RF and video signaling.
Analysis on measured signal retrieval approaches in non-modulation pyramid wavefront sensor
NASA Astrophysics Data System (ADS)
Wang, Jianxin; Bai, Fuzhong; Ning, Yu; Wang, Shengqian; Zhang, Lanqiang
2010-11-01
Pyramid wavefront sensor (PWFS) without modulation is prevailing over one with modulation. So far how to describe measured signals of non-modulation PWFS needs deeply research. In this paper, the theory of the non-modulation PWFS is briefly presented according to wave optics. This paper analyses the existing four approaches in theory. By numerical simulation this paper further verifies the performance of four approaches under the experiment condition. The result shows that the approach with total intensity of pixels conjugate to the same spot in the pupil as signal denominator is the best choice for the non-modulation PWFS in closed-loop correction.
Demonstration of an RF front-end based on GaN HEMT technology
NASA Astrophysics Data System (ADS)
Ture, Erdin; Musser, Markus; Hülsmann, Axel; Quay, Rüdiger; Ambacher, Oliver
2017-05-01
The effectiveness of the developed front-end on blocking the communication link of a commercial drone vehicle has been demonstrated in this work. A jamming approach has been taken in a broadband fashion by using GaN HEMT technology. Equipped with a modulated-signal generator, a broadband power amplifier, and an omni-directional antenna, the proposed system is capable of producing jamming signals in a very wide frequency range between 0.1 - 3 GHz. The maximum RF output power of the amplifier module has been software-limited to 27 dBm (500 mW), complying to the legal spectral regulations of the 2.4 GHz ISM band. In order to test the proof of concept, a real-world scenario has been prepared in which a commercially-available quadcopter UAV is flown in a controlled environment while the jammer system has been placed in a distance of about 10 m from the drone. It has been proven that the drone of interest can be neutralized as soon as it falls within the range of coverage (˜3 m) which endorses the promising potential of the broadband jamming approach.
Efficient Direct-Matching Rectenna Design for RF Power Transfer Applications
NASA Astrophysics Data System (ADS)
Keyrouz, Shady; Visser, Huib
2013-12-01
This paper presents the design, simulation, fabrication and measurements of a 50 ohm rectenna system. The paper investigates each part (in terms of input impedance) of the rectenna system starting from the antenna, followed by the matching network, to the rectifier. The system consists of an antenna, which captures the transmitted RF signal, connected to a rectifier which converts the AC captured signal into a DC power signal. For maximum power transfer, a matching network is designed between the rectifier and the antenna. At an input power level of -10 dBm, the system is able to achieve an RF/DC power conversion efficiency of 49.7%.
NASA Astrophysics Data System (ADS)
Zhang, Fangliu; He, Jing; Deng, Rui; Chen, Qinghui; Chen, Lin
2016-10-01
A modulation format, orthogonal pulse amplitude modulation and discrete multitone modulation (O-PAM-DMT), is experimentally demonstrated in a hybrid fiber-visible laser light communication (fiber-VLLC) system using a cost-effective directly modulated laser and blue laser diode. In addition, low overhead is achieved by utilizing only one training sequence to implement synchronization and channel estimation. Through adjusting the ratio of PAM and DMT signal, three types of O-PAM-DMT signals are investigated. After transmission over a 20-km standard single-mode fiber and 5-m free-space VLLC, the receiver sensitivity for 4.36-Gbit/s O-PAM-DMT signals can be improved by 0.4, 1.4, and 2.7 dB, respectively, at a bit error rate of 1×10-3, compared with a conventional DMT signal.
Thin film lithium niobate electro-optic modulator with terahertz operating bandwidth.
Mercante, Andrew J; Shi, Shouyuan; Yao, Peng; Xie, Linli; Weikle, Robert M; Prather, Dennis W
2018-05-28
We present a thin film crystal ion sliced (CIS) LiNbO 3 phase modulator that demonstrates an unprecedented measured electro-optic (EO) response up to 500 GHz. Shallow rib waveguides are utilized for guiding a single transverse electric (TE) optical mode, and Au coplanar waveguides (CPWs) support the modulating radio frequency (RF) mode. Precise index matching between the co-propagating RF and optical modes is responsible for the device's broadband response, which is estimated to extend even beyond 500 GHz. Matching the velocities of these co-propagating RF and optical modes is realized by cladding the modulator's interaction region in a thin UV15 polymer layer, which increases the RF modal index. The fabricated modulator possesses a tightly confined optical mode, which lends itself to a strong interaction between the modulating RF field and the guided optical carrier; resulting in a measured DC half-wave voltage of 3.8 V·cm -1 . The design, fabrication, and characterization of our broadband modulator is presented in this work.
Antimultipath communication by injecting tone into null in signal spectrum
NASA Technical Reports Server (NTRS)
Davarian, Faramaz (Inventor)
1987-01-01
A transmitter for digital radio communication creates a null by balanced encoding of data modulated on an RF carrier, and inserts a calibration tone within the null. This is accomplished by having the calibration tone coincide in phase and frequency with the transmitted radio frequency output, for coherent demodulation of data at the receiver where the tone calibration signal is extracted and used for multipath fading compensation.
Hybrid RF / Optical Communication Terminal with Spherical Primary Optics for Optical Reception
NASA Technical Reports Server (NTRS)
Charles, Jeffrey R.; Hoppe, Daniel H.; Sehic, Asim
2011-01-01
Future deep space communications are likely to employ not only the existing RF uplink and downlink, but also a high capacity optical downlink. The Jet Propulsion Laboratory (JPL) is currently investigating the benefits of a ground based hybrid RF and deep space optical terminal based on limited modification of existing 34 meter antenna designs. The ideal design would include as large an optical aperture as technically practical and cost effective, cause minimal impact to RF performance, and remain cost effective even when compared to a separate optical terminal of comparable size. Numerous trades and architectures have been considered, including shared RF and optical apertures having aspheric optics and means to separate RF and optical signals, plus, partitioned apertures in which various zones of the primary are dedicated to optical reception. A design based on the latter is emphasized in this paper, employing spherical primary optics and a new version of a "clamshell" corrector that is optimized to fit within the limited space between the antenna sub-reflector and the existing apex structure that supports the subreflector. The mechanical design of the hybrid accommodates multiple spherical primary mirror panels in the central 11 meters of the antenna, and integrates the clamshell corrector and optical receiver modules with antenna hardware using existing attach points to the maximum extent practical. When an optical collection area is implemented on a new antenna, it is possible to design the antenna structure to accommodate the additional weight of optical mirrors providing an equivalent aperture of several meters diameter. The focus of our near term effort is to use optics with the 34 meter DSS-13 antenna at Goldstone to demonstrate spatial optical acquisition and tracking capability using an optical system that is temporarily integrated into the antenna.
Commissioning of two RF operation modes for RF negative ion source experimental setup at HUST
NASA Astrophysics Data System (ADS)
Li, D.; Chen, D.; Liu, K.; Zhao, P.; Zuo, C.; Wang, X.; Wang, H.; Zhang, L.
2017-08-01
An RF-driven negative ion source experimental setup, without a cesium oven and an extraction system, has been built at Huazhong University of Science and Technology (HUST). The working gas is hydrogen, and the typical operational gas pressure is 0.3 Pa. The RF generator is capable of delivering up to 20 kW at 0.9 - 1.1 MHz, and has two operation modes, the fixed-frequency mode and auto-tuning mode. In the fixed-frequency mode, it outputs a steady RF forward power (Pf) at a fixed frequency. In the auto-tuning mode, it adjusts the operating frequency to seek and track the minimum standing wave ratio (SWR) during plasma discharge. To achieve fast frequency tuning, the RF signal source adopts a direct digital synthesizer (DDS). To withstand high SWR during the discharge, a tetrode amplifier is chosen as the final stage amplifier. The trend of maximum power reflection coefficient |ρ|2 at plasma ignition is presented at the fixed frequency of 1.02 MHz with the Pf increasing from 5 kW to 20 kW, which shows the maximum |ρ|2 tends to be "steady" under high RF power. The experiments in auto-tuning mode fail due to over-current protection of screen grid. The possible reason is the relatively large equivalent anode impedance caused by the frequency tuning. The corresponding analysis and possible solution are presented.
NASA Astrophysics Data System (ADS)
Puiu, A.; Becker, D.; Bennett, D.; Faverzani, M.; Ferri, E.; Fowler, J.; Gard, J.; Hays-Wehle, J.; Hilton, G.; Giachero, A.; Maino, M.; Mates, J.; Nucciotti, A.; Schmidt, D.; Swetz, D.; Ullom, J.; Vale, L.
2017-09-01
Measuring the neutrino mass is one the most compelling issue in particle physics. HOLMES is an experiment funded by the European Research Council for a direct measurement of neutrino mass. HOLMES will perform a precise measurement of the end point of the Electron Capture decay spectrum of 163Ho in order to extract information on neutrino mass with a sensitivity as low as 1 eV. HOLMES, in its final configuration will deploy a 1000 pixel array of low temperature microcalorimeters: each calorimeter consists of an absorber, where the Ho atoms will be implanted, coupled to a Transition Edge Sensor thermometer. The detectors will be kept at the working temperature of ˜70 mK using a dilution refrigerator. In order to gather the required 3 × 1013 events in a three year long data taking with a pile up fraction as low as 10-4, detectors must fulfill rather high speed and resolution requirements, i.e. 10 µs rise time and 4 eV resolution. To ensure such performances with an efficient read out technique for very large detectors array kept at low temperature inside a cryostat is no trivial matter: at the moment, the most appealing read out technique applicable to large arrays of Transition Edge Sensors is rf-SQUID multiplexing. It is based on the use of rf-SQUIDs as input devices with flux ramp modulation for linearisation purposes; the rf-SQUID is then coupled to a super-conductive λ/4-wave resonator in the GHz range, and the modulated signal is finally read out using the homodyne technique.
PIC microcontroller-based RF wireless ECG monitoring system.
Oweis, R J; Barhoum, A
2007-01-01
This paper presents a radio-telemetry system that provides the possibility of ECG signal transmission from a patient detection circuit via an RF data link. A PC then receives the signal through the National Instrument data acquisition card (NIDAQ). The PC is equipped with software allowing the received ECG signals to be saved, analysed, and sent by email to another part of the world. The proposed telemetry system consists of a patient unit and a PC unit. The amplified and filtered ECG signal is sampled 360 times per second, and the A/D conversion is performed by a PIC16f877 microcontroller. The major contribution of the final proposed system is that it detects, processes and sends patients ECG data over a wireless RF link to a maximum distance of 200 m. Transmitted ECG data with different numbers of samples were received, decoded by means of another PIC microcontroller, and displayed using MATLAB program. The designed software is presented in a graphical user interface utility.
The Application of Fiber Optic Wavelength Division Multiplexing in RF Avionics
NASA Technical Reports Server (NTRS)
Ngo, Duc; Nguyen, Hung; Atiquzzaman, Mohammed; Sluss, James J., Jr.; Refai, Hakki H.
2004-01-01
This paper demonstrates a successful application of wavelength division multiplexing (WDM) to the avionics environment to support analog RF signal transmission. We investigate the simultaneous transmission of four RF signals (channels) over a single optical fiber. These four analog channels are sequentially multiplexed and demultiplexed at different points along a fiber optic backbone to more closely emulate the conditions found onboard aircraft. We present data from measurements of signal-to-noise ratio (SNR), transmission response (loss and gain), group delay that defines phase distortion, and dynamic range that defines nonlinear distortion. The data indicate that WDM is well-suited for avionics applications.
Extracting a shape function for a signal with intra-wave frequency modulation.
Hou, Thomas Y; Shi, Zuoqiang
2016-04-13
In this paper, we develop an effective and robust adaptive time-frequency analysis method for signals with intra-wave frequency modulation. To handle this kind of signals effectively, we generalize our data-driven time-frequency analysis by using a shape function to describe the intra-wave frequency modulation. The idea of using a shape function in time-frequency analysis was first proposed by Wu (Wu 2013 Appl. Comput. Harmon. Anal. 35, 181-199. (doi:10.1016/j.acha.2012.08.008)). A shape function could be any smooth 2π-periodic function. Based on this model, we propose to solve an optimization problem to extract the shape function. By exploring the fact that the shape function is a periodic function with respect to its phase function, we can identify certain low-rank structure of the signal. This low-rank structure enables us to extract the shape function from the signal. Once the shape function is obtained, the instantaneous frequency with intra-wave modulation can be recovered from the shape function. We demonstrate the robustness and efficiency of our method by applying it to several synthetic and real signals. One important observation is that this approach is very stable to noise perturbation. By using the shape function approach, we can capture the intra-wave frequency modulation very well even for noise-polluted signals. In comparison, existing methods such as empirical mode decomposition/ensemble empirical mode decomposition seem to have difficulty in capturing the intra-wave modulation when the signal is polluted by noise. © 2016 The Author(s).
Parasitic modulation of electromagnetic signals caused by time-varying plasma
DOE Office of Scientific and Technical Information (OSTI.GOV)
Yang, Min, E-mail: merovingia1911@126.com; Li, Xiaoping; Xie, Kai
2015-02-15
An experiment on the propagation of electromagnetic (EM) signals in continuous time-varying plasma is described. The time-varying characteristics of plasma are considered to cause a parasitic modulation in both amplitude and phase, and the strength of this modulation, which carries the information of the electron density profile, is closely related to the plasma frequency and the incident wave frequency. Through theoretical analysis, we give an explanation and mechanism of the interaction between the continuous time-varying plasma and EM waves, which is verified by a comparative analysis with experiments performed under the same conditions. The effects of this modulation on themore » EM signals in the plasma sheath cannot be ignored.« less
High efficiency RF amplifier development over wide dynamic range for accelerator application
NASA Astrophysics Data System (ADS)
Mishra, Jitendra Kumar; Ramarao, B. V.; Pande, Manjiri M.; Joshi, Gopal; Sharma, Archana; Singh, Pitamber
2017-10-01
Superconducting (SC) cavities in an accelerating section are designed to have the same geometrical velocity factor (βg). For these cavities, Radio Frequency (RF) power needed to accelerate charged particles varies with the particle velocity factor (β). RF power requirement from one cavity to other can vary by 2-5 dB within the accelerating section depending on the energy gain in the cavity and beam current. In this paper, we have presented an idea to improve operating efficiency of the SC RF accelerators using envelope tracking technique. A study on envelope tracking technique without feedback is carried out on a 1 kW, 325 MHz, class B (conduction angle of 180 degrees) tuned load power amplifier (PA). We have derived expressions for the efficiency and power output for tuned load amplifier operating on the envelope tracking technique. From the derived expressions, it is observed that under constant load resistance to the device (MOSFET), optimum amplifier efficiency is invariant whereas output power varies with the square of drain bias voltage. Experimental results on 1 kW PA module show that its optimum efficiency is always greater than 62% with variation less than 5% from mean value over 7 dB dynamic range. Low power amplifier modules are the basic building block for the high power amplifiers. Therefore, results for 1 kW PA modules remain valid for the high power solid state amplifiers built using these PA modules. The SC RF accelerators using these constant efficiency power amplifiers can improve overall accelerator efficiency.
Characterization of the first RF coil dedicated to 1.5 T MR guided radiotherapy
NASA Astrophysics Data System (ADS)
Hoogcarspel, Stan J.; Zijlema, Stefan E.; Tijssen, Rob H. N.; Kerkmeijer, Linda G. W.; Jürgenliemk-Schulz, Ina M.; Lagendijk, Jan J. W.; Raaymakers, Bas W.
2018-01-01
The purpose of this study is to investigate the attenuation characteristics of a novel radiofrequency (RF) coil, which is the first coil that is solely dedicated to MR guided radiotherapy with a 1.5 T MR-linac. Additionally, we investigated the impact of the treatment beam on the MRI performance of this RF coil. First, the attenuation characteristics of the RF coil were characterized. Second, we investigated the impact of the treatment beam on the MRI performance of the RF coil. We additionally demonstrated the ability of the anterior coil to attenuate returning electrons and thereby reducing the dose to the skin at the distal side of the treatment beam. Intensity modulated radiation therapy simulation of a clinically viable treatment plan for spinal bone metastasis shows a decrease of the dose to the planned tumor volume of 1.8% as a result of the MR coil around the patient. Ionization chamber and film measurements show that the anterior and posterior coil attenuate the beam homogeneously by 0.4% and 2.2%, respectively. The impact of the radiation resulted in a slight drop of the time-course signal-to-noise ratio and was dependent on imaging parameters. However, we could not observe any image artifacts resulting from this irradiation in any situation. In conclusion, the investigated MR-coil can be utilized for treatments with the 1.5 T-linac system. However, there is still room for improvement when considering both the dosimetric and imaging performance of the coil.
Wireless RF communication in biomedical applications
NASA Astrophysics Data System (ADS)
Jones, Inke; Ricciardi, Lucas; Hall, Leonard; Hansen, Hedley; Varadan, Vijay; Bertram, Chris; Maddocks, Simon; Enderling, Stefan; Saint, David; Al-Sarawi, Said; Abbott, Derek
2008-02-01
This paper focuses on wireless transcutaneous RF communication in biomedical applications. It discusses current technology, restrictions and applications and also illustrates possible future developments. It focuses on the application in biotelemetry where the system consists of a transmitter and a receiver with a transmission link in between. The transmitted information can either be a biopotential or a nonelectric value like arterial pressure, respiration, body temperature or pH value. In this paper the use of radio-frequency (RF) communication and identification for those applications is described. Basically, radio-frequency identification or RFID is a technology that is analogous to the working principle of magnetic barcode systems. Unlike magnetic barcodes, passive RFID can be used in extreme climatic conditions—also the tags do not need to be within close proximity of the reader. Our proposed solution is to exploit an exciting new development in making circuits on polymers without the need for battery power. This solution exploits the principle of a surface acoustic wave (SAW) device on a polymer substrate. The SAW device is a set of interdigitated conducting fingers on the polymer substrate. If an appropriate RF signal is sent to the device, the fingers act as microantennas that pick up the signal, and this energy is then converted into acoustic waves that travel across the surface of the polymer substrate. Being a flexible polymer, the acoustic waves cause stresses that can either contract or stretch the material. In our case we mainly focus on an RF controllable microvalve that could ultimately be used for fertility control.
NASA Astrophysics Data System (ADS)
Pan, Zeyu; Subbaraman, Harish; Zhang, Cheng; Li, Qiaochu; Xu, Xiaochuan; Chen, Xiangning; Zhang, Xingyu; Zou, Yi; Panday, Ashwin; Guo, L. Jay; Chen, Ray T.
2016-02-01
Phased-array antenna (PAA) technology plays a significant role in modern day radar and communication networks. Truetime- delay (TTD) enabled beam steering networks provide several advantages over their electronic counterparts, including squint-free beam steering, low RF loss, immunity to electromagnetic interference (EMI), and large bandwidth control of PAAs. Chip-scale and integrated TTD modules promise a miniaturized, light-weight system; however, the modules are still rigid and they require complex packaging solutions. Moreover, the total achievable time delay is still restricted by the wafer size. In this work, we propose a light-weight and large-area, true-time-delay beamforming network that can be fabricated on light-weight and flexible/rigid surfaces utilizing low-cost "printing" techniques. In order to prove the feasibility of the approach, a 2-bit thermo-optic polymer TTD network is developed using a combination of imprinting and ink-jet printing. RF beam steering of a 1×4 X-band PAA up to 60° is demonstrated. The development of such active components on large area, light-weight, and low-cost substrates promises significant improvement in size, weight, and power (SWaP) requirements over the state-of-the-art.
An investigation of the DC and RF performance of InP DHBTs transferred to RF CMOS wafer substrate
NASA Astrophysics Data System (ADS)
Ren, Kun; Zheng, Jiachen; Lu, Haiyan; Liu, Jun; Wu, Lishu; Zhou, Wenyong; Cheng, Wei
2018-05-01
This paper investigated the DC and RF performance of the InP double heterojunction bipolar transistors (DHBTs) transferred to RF CMOS wafer substrate. The measurement results show that the maximum values of the DC current gain of a substrate transferred device had one emitter finger, of 0.8 μm in width and 5 μm in length, are changed unobviously, while the cut-off frequency and the maximum oscillation frequency are decreased from 220 to 171 GHz and from 204 to 154 GHz, respectively. In order to have a detailed insight on the degradation of the RF performance, small-signal models for the InP DHBT before and after substrate transferred are presented and comparably extracted. The extracted results show that the degradation of the RF performance of the device transferred to RF CMOS wafer substrate are mainly caused by the additional introduced substrate parasitics and the increase of the capacitive parasitics induced by the substrate transfer process itself. Project supported by the National Natural Science Foundation of China (No. 61331006) and the Natural Science Foundation of Zhejiang Province (No. Y14F010017).
Heart Rate Detection During Sleep Using a Flexible RF Resonator and Injection-Locked PLL Sensor.
Kim, Sung Woo; Choi, Soo Beom; An, Yong-Jun; Kim, Byung-Hyun; Kim, Deok Won; Yook, Jong-Gwan
2015-11-01
Novel nonintrusive technologies for wrist pulse detection have been developed and proposed as systems for sleep monitoring using three types of radio frequency (RF) sensors. The three types of RF sensors for heart rate measurement on wrist are a flexible RF single resonator, array resonators, and an injection-locked PLL resonator sensor. To verify the performance of the new RF systems, we compared heart rates between presleep time and postsleep onset time. Heart rates of ten subjects were measured using the RF systems during sleep. All three RF devices detected heart rates at 0.2 to 1 mm distance from the skin of the wrist over clothes made of cotton fabric. The wrist pulse signals of a flexible RF single resonator were consistent with the signals obtained by a portable piezoelectric transducer as a reference. Then, we confirmed that the heart rate after sleep onset time significantly decreased compared to before sleep. In conclusion, the RF system can be utilized as a noncontact nonintrusive method for measuring heart rates during sleep.
NASA Technical Reports Server (NTRS)
Downie, John D.
1995-01-01
Images with signal-dependent noise present challenges beyond those of images with additive white or colored signal-independent noise in terms of designing the optimal 4-f correlation filter that maximizes correlation-peak signal-to-noise ratio, or combinations of correlation-peak metrics. Determining the proper design becomes more difficult when the filter is to be implemented on a constrained-modulation spatial light modulator device. The design issues involved for updatable optical filters for images with signal-dependent film-grain noise and speckle noise are examined. It is shown that although design of the optimal linear filter in the Fourier domain is impossible for images with signal-dependent noise, proper nonlinear preprocessing of the images allows the application of previously developed design rules for optimal filters to be implemented on constrained-modulation devices. Thus the nonlinear preprocessing becomes necessary for correlation in optical systems with current spatial light modulator technology. These results are illustrated with computer simulations of images with signal-dependent noise correlated with binary-phase-only filters and ternary-phase-amplitude filters.
NASA Astrophysics Data System (ADS)
Li, Xinying; Xiao, Jiangnan
2015-06-01
We propose a novel scheme for optical frequency-locked multi-carrier generation based on one electro-absorption modulated laser (EML) and one phase modulator (PM) in cascade driven by different sinusoidal radio-frequency (RF) clocks. The optimal operating zone for the cascaded EML and PM is found out based on theoretical analysis and numerical simulation. We experimentally demonstrate 25 optical subcarriers with frequency spacing of 12.5 GHz and power difference less than 5 dB can be generated based on the cascaded EML and PM operating in the optimal zone, which agrees well with the numerical simulation. We also experimentally demonstrate 28-Gbaud polarization division multiplexing quadrature phase shift keying (PDM-QPSK) modulated coherent optical transmission based on the cascaded EML and PM. The bit error ratio (BER) can be below the pre-forward-error-correction (pre-FEC) threshold of 3.8 × 10-3 after 80-km single-mode fiber-28 (SMF-28) transmission.
Usselman, Robert J.; Hill, Iain; Singel, David J.; Martino, Carlos F.
2014-01-01
The effects of weak magnetic fields on the biological production of reactive oxygen species (ROS) from intracellular superoxide (O2 •−) and extracellular hydrogen peroxide (H2O2) were investigated in vitro with rat pulmonary arterial smooth muscle cells (rPASMC). A decrease in O2 •− and an increase in H2O2 concentrations were observed in the presence of a 7 MHz radio frequency (RF) at 10 μTRMS and static 45 μT magnetic fields. We propose that O2 •− and H2O2 production in some metabolic processes occur through singlet-triplet modulation of semiquinone flavin (FADH•) enzymes and O2 •− spin-correlated radical pairs. Spin-radical pair products are modulated by the 7 MHz RF magnetic fields that presumably decouple flavin hyperfine interactions during spin coherence. RF flavin hyperfine decoupling results in an increase of H2O2 singlet state products, which creates cellular oxidative stress and acts as a secondary messenger that affects cellular proliferation. This study demonstrates the interplay between O2 •− and H2O2 production when influenced by RF magnetic fields and underscores the subtle effects of low-frequency magnetic fields on oxidative metabolism, ROS signaling, and cellular growth. PMID:24681944
Modulation Classification of Satellite Communication Signals Using Cumulants and Neural Networks
NASA Technical Reports Server (NTRS)
Smith, Aaron; Evans, Michael; Downey, Joseph
2017-01-01
National Aeronautics and Space Administration (NASA)'s future communication architecture is evaluating cognitive technologies and increased system intelligence. These technologies are expected to reduce the operational complexity of the network, increase science data return, and reduce interference to self and others. In order to increase situational awareness, signal classification algorithms could be applied to identify users and distinguish sources of interference. A significant amount of previous work has been done in the area of automatic signal classification for military and commercial applications. As a preliminary step, we seek to develop a system with the ability to discern signals typically encountered in satellite communication. Proposed is an automatic modulation classifier which utilizes higher order statistics (cumulants) and an estimate of the signal-to-noise ratio. These features are extracted from baseband symbols and then processed by a neural network for classification. The modulation types considered are phase-shift keying (PSK), amplitude and phase-shift keying (APSK),and quadrature amplitude modulation (QAM). Physical layer properties specific to the Digital Video Broadcasting - Satellite- Second Generation (DVB-S2) standard, such as pilots and variable ring ratios, are also considered. This paper will provide simulation results of a candidate modulation classifier, and performance will be evaluated over a range of signal-to-noise ratios, frequency offsets, and nonlinear amplifier distortions.
NASA Astrophysics Data System (ADS)
Grimminck, Dennis L. A. G.; Vasa, Suresh K.; Meerts, W. Leo; Kentgens, P. M.
2011-06-01
A global optimisation scheme for phase modulated proton homonuclear decoupling sequences in solid-state NMR is presented. Phase modulations, parameterised by DUMBO Fourier coefficients, were optimized using a Covariance Matrix Adaptation Evolution Strategies algorithm. Our method, denoted EASY-GOING homonuclear decoupling, starts with featureless spectra and optimises proton-proton decoupling, during either proton or carbon signal detection. On the one hand, our solutions closely resemble (e)DUMBO for moderate sample spinning frequencies and medium radio-frequency (rf) field strengths. On the other hand, the EASY-GOING approach resulted in a superior solution, achieving significantly better resolved proton spectra at very high 680 kHz rf field strength. N. Hansen, and A. Ostermeier. Evol. Comput. 9 (2001) 159-195 B. Elena, G. de Paepe, L. Emsley. Chem. Phys. Lett. 398 (2004) 532-538
NASA Astrophysics Data System (ADS)
Haram, M.; Wang, T.; Gu, F.; Ball, A. D.
2012-05-01
Motor current signal analysis has been an effective way for many years of monitoring electrical machines themselves. However, little work has been carried out in using this technique for monitoring their downstream equipment because of difficulties in extracting small fault components in the measured current signals. This paper investigates the characteristics of electrical current signals for monitoring the faults from a downstream gearbox using a modulation signal bispectrum (MSB), including phase effects in extracting small modulating components in a noisy measurement. An analytical study is firstly performed to understand amplitude, frequency and phase characteristics of current signals due to faults. It then explores the performance of MSB analysis in detecting weak modulating components in current signals. Experimental study based on a 10kw two stage gearbox, driven by a three phase induction motor, shows that MSB peaks at different rotational frequencies can be based to quantify the severity of gear tooth breakage and the degrees of shaft misalignment. In addition, the type and location of a fault can be recognized based on the frequency at which the change of MSB peak is the highest among different frequencies.
NASA Astrophysics Data System (ADS)
Wu, Tonggen; Ma, Jianxin
2017-12-01
This paper proposes an original scheme to generate the photonic dual-tone optical millimeter wave (MMW) carrying the 16-star quadrature-amplitude-modulation (QAM) signal via an optical phase modulator (PM) and an interleaver with adaptive photonic frequency-nonupling without phase precoding. To enable the generated optical vector MMW signal to resist the power fading effect caused by the fiber chromatic dispersion, the modulated -5th- and +4th-order sidebands are selected from the output of the PM, which is driven by the precoding 16-star QAM signal. The modulation index of the PM is optimized to gain the maximum opto-electrical conversion efficiency. A radio over fiber link is built by simulation, and the simulated constellations and the bit error rate graph demonstrate that the frequency-nonupling 16-star QAM MMW signal has good transmission performance. The simulation results agree well with our theoretical results.
Cell Size and Growth Rate Are Modulated by TORC2-Dependent Signals.
Lucena, Rafael; Alcaide-Gavilán, Maria; Schubert, Katherine; He, Maybo; Domnauer, Matthew G; Marquer, Catherine; Klose, Christian; Surma, Michal A; Kellogg, Douglas R
2018-01-22
The size of all cells, from bacteria to vertebrates, is proportional to the growth rate set by nutrient availability, but the underlying mechanisms are unknown. Here, we show that nutrients modulate cell size and growth rate via the TORC2 signaling network in budding yeast. An important function of the TORC2 network is to modulate synthesis of ceramide lipids, which play roles in signaling. TORC2-dependent control of ceramide signaling strongly influences both cell size and growth rate. Thus, cells that cannot make ceramides fail to modulate their growth rate or size in response to changes in nutrients. PP2A associated with the Rts1 regulatory subunit (PP2A Rts1 ) is embedded in a feedback loop that controls TORC2 signaling and helps set the level of TORC2 signaling to match nutrient availability. Together, the data suggest a model in which growth rate and cell size are mechanistically linked by ceramide-dependent signals arising from the TORC2 network. Copyright © 2017 Elsevier Ltd. All rights reserved.
NASA Astrophysics Data System (ADS)
Kiasaleh, Kamran
1994-02-01
A novel optical phase-locked loop (OPLL) system for the self-homodyne detection of digitally phase modulated optical signals is introduced. A Mach-Zehnder type interferometer is used to self-homodyne binary phase-modulated optical signals with an external phase modulator inserted in the control arm of the interferometer.
Signal recognition and parameter estimation of BPSK-LFM combined modulation
NASA Astrophysics Data System (ADS)
Long, Chao; Zhang, Lin; Liu, Yu
2015-07-01
Intra-pulse analysis plays an important role in electronic warfare. Intra-pulse feature abstraction focuses on primary parameters such as instantaneous frequency, modulation, and symbol rate. In this paper, automatic modulation recognition and feature extraction for combined BPSK-LFM modulation signals based on decision theoretic approach is studied. The simulation results show good recognition effect and high estimation precision, and the system is easy to be realized.
Jitter model and signal processing techniques for pulse width modulation optical recording
NASA Technical Reports Server (NTRS)
Liu, Max M.-K.
1991-01-01
A jitter model and signal processing techniques are discussed for data recovery in Pulse Width Modulation (PWM) optical recording. In PWM, information is stored through modulating sizes of sequential marks alternating in magnetic polarization or in material structure. Jitter, defined as the deviation from the original mark size in the time domain, will result in error detection if it is excessively large. A new approach is taken in data recovery by first using a high speed counter clock to convert time marks to amplitude marks, and signal processing techniques are used to minimize jitter according to the jitter model. The signal processing techniques include motor speed and intersymbol interference equalization, differential and additive detection, and differential and additive modulation.
Multiband DSB-SC modulated radio over IsOWC link with coherent homodyne detection
NASA Astrophysics Data System (ADS)
Kang, Zong; Zhu, Jiang
2018-02-01
In this paper, we present a multiband double sideband-suppressed carrier (DSB-SC) modulated radio over intersatellite optical wireless communication (IsOWC) link with coherent homodyne detection. The proposed system can provide the transparent transport of multiband radio frequency (RF) signals with higher linearity and better receiver sensitivity than the intensity modulated with direct detection (IM/DD) scheme. The full system model and the exactly analytical expression of signal to noise and distortion ratio (SNDR) are derived considering the third-order intermodulation product and amplifier spontaneous emission (ASE) noise. The finite extinction ratio (ER) of Mach-Zehnder Modulator (MZM) and the saturation property of erbium doped fiber amplifier (EDFA) are also considered. Numerical results of SNDR with various numbers of subchannels and ERs are given. Results indicate that the optimal modulation index exists to maximize the SNDR and the power of local oscillator (LO) carrier should be within an appropriate range.
Integrated Module and Gene-Specific Regulatory Inference Implicates Upstream Signaling Networks
Roy, Sushmita; Lagree, Stephen; Hou, Zhonggang; Thomson, James A.; Stewart, Ron; Gasch, Audrey P.
2013-01-01
Regulatory networks that control gene expression are important in diverse biological contexts including stress response and development. Each gene's regulatory program is determined by module-level regulation (e.g. co-regulation via the same signaling system), as well as gene-specific determinants that can fine-tune expression. We present a novel approach, Modular regulatory network learning with per gene information (MERLIN), that infers regulatory programs for individual genes while probabilistically constraining these programs to reveal module-level organization of regulatory networks. Using edge-, regulator- and module-based comparisons of simulated networks of known ground truth, we find MERLIN reconstructs regulatory programs of individual genes as well or better than existing approaches of network reconstruction, while additionally identifying modular organization of the regulatory networks. We use MERLIN to dissect global transcriptional behavior in two biological contexts: yeast stress response and human embryonic stem cell differentiation. Regulatory modules inferred by MERLIN capture co-regulatory relationships between signaling proteins and downstream transcription factors thereby revealing the upstream signaling systems controlling transcriptional responses. The inferred networks are enriched for regulators with genetic or physical interactions, supporting the inference, and identify modules of functionally related genes bound by the same transcriptional regulators. Our method combines the strengths of per-gene and per-module methods to reveal new insights into transcriptional regulation in stress and development. PMID:24146602
Development of 24GHz Rectenna for Receiving and Rectifying Modulated Waves
NASA Astrophysics Data System (ADS)
Shinohara, Naoki; Hatano, Ken
2014-11-01
In this paper, we show experimental results of RF-DC conversion with modulated 24GHz waves. We have already developed class-F MMIC rectenna with resonators for higher harmonics at no modulated 24GHz microwave for RF energy transfer. Dimensions of the MMIC rectifying circuit is 1 mm × 3 mm on GaAs. Maximum RF-DC conversion efficiency is measured 47.9% for a 210 mW microwave input of 24 GHz with a 120 Ω load. The class-F rectenna is based on a single shunt full-wave rectifier. For future application of a simultaneous energy and information transfer system or an energy harvesting from broadcasting waves, input microwave will be modulated. In this paper, we show an experimental result of RF-DC conversion of the class-F rectenna with 24GHz waves modulated by 16QAM as 1st modulation and OFDM as 2nd modulation.
NASA Astrophysics Data System (ADS)
Zhu, Lili; Wu, Jingping; Lin, Guimin; Hu, Liangjun; Li, Hui
2016-10-01
With high spatial resolution of ultrasonic location and high sensitivity of optical detection, ultrasound-modulated optical tomography (UOT) is a promising noninvasive biological tissue imaging technology. In biological tissue, the ultrasound-modulated light signals are very weak and are overwhelmed by the strong unmodulated light signals. It is a difficulty and key to efficiently pick out the weak modulated light from strong unmodulated light in UOT. Under the effect of an ultrasonic field, the scattering light intensity presents a periodic variation as the ultrasonic frequency changes. So the modulated light signals would be escape from the high unmodulated light signals, when the modulated light signals and the ultrasonic signal are processed cross correlation operation by a lock-in amplifier and without a chopper. Experimental results indicated that the signal-to-noise ratio of UOT is significantly improved by a lock-in amplifier, and the higher the repetition frequency of pulsed ultrasonic wave, the better the signal-to-noise ratio of UOT.
Gear wear monitoring by modulation signal bispectrum based on motor current signal analysis
NASA Astrophysics Data System (ADS)
Zhang, Ruiliang; Gu, Fengshou; Mansaf, Haram; Wang, Tie; Ball, Andrew D.
2017-09-01
Gears are important mechanical components for power transmissions. Tooth wear is one of the most common failure modes, which can present throughout a gear's lifetime. It is significant to accurately monitor gear wear progression in order to take timely predictive maintenances. Motor current signature analysis (MCSA) is an effective and non-intrusive approach which is able to monitor faults from both electrical and mechanical systems. However, little research has been reported in monitoring the gear wear and estimating its severity based on MCSA. This paper presents a novel gear wear monitoring method through a modulation signal bispectrum based motor current signal analysis (MSB-MCSA). For a steady gear transmission, it is inevitable to exist load and speed oscillations due to various errors including wears. These oscillations can induce small modulations in the current signals of the driving motor. MSB is particularly effective in characterising such small modulation signals. Based on these understandings, the monitoring process was implemented based on the current signals from a run-to-failure test of an industrial two stages helical gearbox under a moderate accelerated fatigue process. At the initial operation of the test, MSB analysis results showed that the peak values at the bifrequencies of gear rotations and the power supply can be effective monitoring features for identifying faulty gears and wear severity as they exhibit agreeable changes with gear loads. A monotonically increasing trend established by these features allows a clear indication of the gear wear progression. The dismantle inspection at 477 h of operation, made when one of the monitored features is about 123% higher than its baseline, has found that there are severe scuffing wear marks on a number of tooth surfaces on the driving gear, showing that the gear endures a gradual wear process during its long test operation. Therefore, it is affirmed that the MSB-MSCA approach proposed is reliable
On the Effects of a Spacecraft Subcarrier Unbalanced Modulator
NASA Technical Reports Server (NTRS)
Nguyen, Tien Manh
1993-01-01
This paper presents mathematical models with associated analysis of the deleterious effects which a spacecraft's subcarrier unbalanced modulator has on the performance of a phase-modulated residual carrier communications link. The undesired spectral components produced by the phase and amplitude imbalances in the subcarrier modulator can cause (1) potential interference to the carrier tracking and (2) degradation in the telemetry bit signal-to-noise ratio (SNR). A suitable model for the unbalanced modulator is developed and the threshold levels of undesired components that fall into the carrier tracking loop are determined. The distribution of the carrier phase error caused by the additive White Gaussian noise (AWGN) and undesired component at the residual RF carrier is derived for the limiting cases. Further, this paper analyses the telemetry bit signal-to-noise ratio degradations due to undesirable spectral components as well as the carrier tracking phase error induced by phase and amplitude imbalances. Numerical results which indicate the sensitivity of the carrier tracking loop and the telemetry symbol-error rate (SER) to various parameters of the models are also provided as a tool in the design of the subcarrier balanced modulator.
Intelligent signal analysis and recognition
NASA Technical Reports Server (NTRS)
Levinson, Robert; Helman, Daniel; Oswalt, Edward
1987-01-01
Progress in the research and development of self-organizing database system that can support the identification and characterization of signals in an RF environment is described. As the radio frequency spectrum becomes more crowded, there are a number of situations that require a characterization of the RF environment. This database system is designed to be practical in applications where communications and other instruments encounter a time varying and complex RF environment. The primary application of this system is the guidance and control of NASA's SETI Microwave Observing Project. Other possible applications include selection of telemety bands for communication with spacecraft, and the scheduling of antenna for radio astronomy are two examples where characterization of the RF environment is required. In these applications, the RF environment is constantly changing, and even experienced operators cannot quickly identify the multitude of signals that can be encountered. Some of these signals are repetitive, others appear to occur sporadically.
Chemical modulation of glycerolipid signaling and metabolic pathways
Scott, Sarah A.; Mathews, Thomas P.; Ivanova, Pavlina T.; Lindsley, Craig W.; Brown, H. Alex
2014-01-01
Thirty years ago, glycerolipids captured the attention of biochemical researchers as novel cellular signaling entities. We now recognize that these biomolecules occupy signaling nodes critical to a number of physiological and pathological processes. Thus, glycerolipid-metabolizing enzymes present attractive targets for new therapies. A number of fields—ranging from neuroscience and cancer to diabetes and obesity—have elucidated the signaling properties of glycerolipids. The biochemical literature teems with newly emerging small molecule inhibitors capable of manipulating glycerolipid metabolism and signaling. This ever-expanding pool of chemical modulators appears daunting to those interested in exploiting glycerolipid-signaling pathways in their model system of choice. This review distills the current body of literature surrounding glycerolipid metabolism into a more approachable format, facilitating the application of small molecule inhibitors to novel systems. PMID:24440821
Modeling of RF/MHD coupling using NIMROD and GENRAY
NASA Astrophysics Data System (ADS)
Jenkins, Thomas G.; Schnack, D. D.; Sovinec, C. R.; Hegna, C. C.; Callen, J. D.; Ebrahimi, F.; Kruger, S. E.; Carlsson, J.; Held, E. D.; Ji, J.-Y.; Harvey, R. W.; Smirnov, A. P.
2008-11-01
We summarize ongoing theoretical/numerical work relevant to the development of a self--consistent framework for the inclusion of RF effects in fluid simulations, specifically considering the stabilization of resistive tearing modes in tokamak (DIII--D--like) geometry by electron cyclotron current drive. Previous investigations [T. G. Jenkins et al., Bull. APS 52, 131 (2007)] have demonstrated that relatively simple (though non--self--consistent) models for the RF--induced currents can be incorporated into the fluid equations, and that these currents can markedly reduce the width of the nonlinearly saturated magnetic islands generated by tearing modes. We report our progress toward the self--consistent modeling of these RF--induced currents. The initial interfacing of the NIMROD* code with the GENRAY/CQL3D** codes (which calculate RF propagation and energy/momentum deposition) is explained, equilibration of RF--induced currents over the plasma flux surfaces is investigated, and initial studies exploring the efficient reduction of saturated island widths through time modulation of the ECCD are presented. Conducted as part of the SWIM*** project; funded by U. S. DoE. *www.nimrodteam.org **www.compxco.com ***www.cswim.org
Ultrabroadband phased-array radio frequency (RF) receivers based on optical techniques
NASA Astrophysics Data System (ADS)
Overmiller, Brock M.; Schuetz, Christopher A.; Schneider, Garrett; Murakowski, Janusz; Prather, Dennis W.
2014-03-01
Military operations require the ability to locate and identify electronic emissions in the battlefield environment. However, recent developments in radio detection and ranging (RADAR) and communications technology are making it harder to effectively identify such emissions. Phased array systems aid in discriminating emitters in the scene by virtue of their relatively high-gain beam steering and nulling capabilities. For the purpose of locating emitters, we present an approach realize a broadband receiver based on optical processing techniques applied to the response of detectors in conformal antenna arrays. This approach utilizes photonic techniques that enable us to capture, route, and process the incoming signals. Optical modulators convert the incoming signals up to and exceeding 110 GHz with appreciable conversion efficiency and route these signals via fiber optics to a central processing location. This central processor consists of a closed loop phase control system which compensates for phase fluctuations induced on the fibers due to thermal or acoustic vibrations as well as an optical heterodyne approach for signal conversion down to baseband. Our optical heterodyne approach uses injection-locked paired optical sources to perform heterodyne downconversion/frequency identification of the detected emission. Preliminary geolocation and frequency identification testing of electronic emissions has been performed demonstrating the capabilities of our RF receiver.
The effect of MRET polymer compound on SAR values of RF phones.
Smirnov, Igor
2008-01-01
This article is related to the proposed hypothesis and experimental data regarding the ability of defined polar polymer compound (MRET polymer) applied to RF phones to increase the dielectric permittivity of water based solutions and to reduce the SAR (Specific Absorption Rate) values inside the "phantom head" filled with the jelly simulating muscle and brain tissues. Due to the high organizational state of fractal structures of MRET polymer compounds and the phenomenon of piezoelectricity, this polymer generates specific subtle, low frequency, non-coherent electromagnetic oscillations (optimal random field) that can affect the hydrogen lattice of the molecular structure of water and subsequently modify the electrodynamic properties of water. The increase of dielectric permittivity of water finally leads to the reduction of the absorption rate of the electromagnetic field by living tissue. The reduction of SAR values is confirmed by the research conducted in June - July of 2006 at RF Exposure Laboratory in Escondido, California. This test also confirmed that the application of MRET polymer to RF phones does not significantly affect the air measurements of RF phone signals, and subsequently does not lead to any significant distortion of transmitted RF signals.
High efficiency low cost monolithic module for SARSAT distress beacons
NASA Technical Reports Server (NTRS)
Petersen, Wendell C.; Siu, Daniel P.
1992-01-01
The program objectives were to develop a highly efficient, low cost RF module for SARSAT beacons; achieve significantly lower battery current drain, amount of heat generated, and size of battery required; utilize MMIC technology to improve efficiency, reliability, packaging, and cost; and provide a technology database for GaAs based UHF RF circuit architectures. Presented in viewgraph form are functional block diagrams of the SARSAT distress beacon and beacon RF module as well as performance goals, schematic diagrams, predicted performances, and measured performances for the phase modulator and power amplifier.
RF pulse shape control in the compact linear collider test facility
NASA Astrophysics Data System (ADS)
Kononenko, Oleksiy; Corsini, Roberto
2018-07-01
The Compact Linear Collider (CLIC) is a study for an electron-positron machine aiming at accelerating and colliding particles at the next energy frontier. The CLIC concept is based on the novel two-beam acceleration scheme, where a high-current low-energy drive beam generates RF in series of power extraction and transfer structures accelerating the low-current main beam. To compensate for the transient beam-loading and meet the energy spread specification requirements for the main linac, the RF pulse shape must be carefully optimized. This was recently modelled by varying the drive beam phase switch times in the sub-harmonic buncher so that, when combined, the drive beam modulation translates into the required voltage modulation of the accelerating pulse. In this paper, the control over the RF pulse shape with the phase switches, that is crucial for the success of the developed compensation model, is studied. The results on the experimental verification of this control method are presented and a good agreement with the numerical predictions is demonstrated. Implications for the CLIC beam-loading compensation model are also discussed.
Therapeutic modulators of STAT signalling for human diseases
Miklossy, Gabriella; Hilliard, Tyvette S.; Turkson, James
2014-01-01
The signal transducer and activator of transcription (STAT) proteins have important roles in biological processes. The abnormal activation of STAT signalling pathways is also implicated in many human diseases, including cancer, autoimmune diseases, rheumatoid arthritis, asthma and diabetes. Over a decade has passed since the first inhibitor of a STAT protein was reported and efforts to discover modulators of STAT signalling as therapeutics continue. This Review discusses the outcomes of the ongoing drug discovery research endeavours against STAT proteins, provides perspectives on new directions for accelerating the discovery of drug candidates, and highlights the noteworthy candidate therapeutics that have progressed to clinical trials. PMID:23903221
Method and apparatus for low-loss signal transmission
NASA Technical Reports Server (NTRS)
Shimabukuro, Fred (Inventor); Yeh, Cavour (Inventor); Fraser, Scott (Inventor); Siegel, Peter (Inventor)
2008-01-01
The present invention relates to the field of radio-frequency (RF) waveguides. More specifically, the present invention pertains to a method and apparatus that provides ultra-low-loss RF waveguide structures targeted between approximately 300 GHz and approximately 30 THz. The RF waveguide includes a hollow core and a flexible honeycomb, periodic-bandgap structure surrounding the hollow core. The flexible honeycomb, periodic-bandgap structure is formed of a plurality of tubes formed of a dielectric material such as of low-loss quartz, polyethylene, or high-resistivity silicon. Using the RF waveguide, a user may attach a terahertz signal source to the waveguide and pass signals through the waveguide, while a terahertz signal receiver receives the signals.
Hirose, H; Sakuma, N; Kaji, N; Suhara, T; Sekijima, M; Nojima, T; Miyakoshi, J
2006-09-01
A large-scale in vitro study focusing on low-level radiofrequency (RF) fields from mobile radio base stations employing the International Mobile Telecommunication 2000 (IMT-2000) cellular system was conducted to test the hypothesis that modulated RF fields induce apoptosis or other cellular stress response that activate p53 or the p53-signaling pathway. First, we evaluated the response of human cells to microwave exposure at a specific absorption rate (SAR) of 80 mW/kg, which corresponds to the limit of the average whole-body SAR for general public exposure defined as a basic restriction by the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines. Second, we investigated whether continuous wave (CW) and wideband code division multiple access (W-CDMA) modulated signal RF fields at 2.1425 GHz induced apoptosis or any signs of stress. Human glioblastoma A172 cells were exposed to W-CDMA radiation at SARs of 80, 250, and 800 mW/kg, and CW radiation at 80 mW/kg for 24 or 48 h. Human IMR-90 fibroblasts from fetal lungs were exposed to both W-CDMA and CW radiation at a SAR of 80 mW/kg for 28 h. Under the RF field exposure conditions described above, no significant differences in the percentage of apoptotic cells were observed between the test groups exposed to RF signals and the sham-exposed negative controls, as evaluated by the Annexin V affinity assay. No significant differences in expression levels of phosphorylated p53 at serine 15 or total p53 were observed between the test groups and the negative controls by the bead-based multiplex assay. Moreover, microarray hybridization and real-time RT-PCR analysis showed no noticeable differences in gene expression of the subsequent downstream targets of p53 signaling involved in apoptosis between the test groups and the negative controls. Our results confirm that exposure to low-level RF signals up to 800 mW/kg does not induce p53-dependent apoptosis, DNA damage, or other stress response in human
The sigma-1 receptor chaperone as an inter-organelle signaling modulator
Su, Tsung-Ping; Hayashi, Teruo; Maurice, Tangui; Buch, Shilpa; Ruoho, Arnold E.
2010-01-01
Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic reticulum (ER)-mitochondrion signaling affects intra-mitochondrial calcium (Ca2+) homeostasis and cellular bioenergetics. ER-nucleus signaling attenuates ER stress. ER-plasma membrane signaling regulates cytosolic Ca2+ homeostasis, and ER-mitochondrion-plasma membrane signaling regulates hippocampal dendritic spine formation. Here we propose that the sigma-1 receptor (Sig-1R), an ER chaperone protein, acts as an inter-organelle signaling modulator. Sig-1Rs normally reside at the ER-mitochondrion contact called the MAM (mitochondrion-associated ER membrane), where Sig-1Rs regulate ER-mitochondrion signaling and the ER-nucleus cross-talk. When cells are stimulated by ligands or undergo prolonged stress, Sig-1Rs translocate from the MAM to the ER reticular network and plasmalemma/plasma membrane to regulate a variety of functional proteins, including ion channels, receptors, and kinases. Thus, the Sig-1R serves as an inter-organelle signaling modulator locally at the MAM and remotely at the plasmalemma/plasma membrane. Many pharmacological/physiological effects of Sig-1Rs may relate to this unique action of Sig-1Rs. PMID:20869780
10 CFR 431.222 - Definitions concerning traffic signal modules and pedestrian modules.
Code of Federal Regulations, 2010 CFR
2010-01-01
..., all portions of the module behind the lens are within the chamber at a temperature of 74 °C and the air temperature in front of the lens is maintained at a minimum of 49 °C. Nominal wattage means the... signal indication that— (1) Consists of a light source, a lens, and all other parts necessary for...
DOE Office of Scientific and Technical Information (OSTI.GOV)
John Musson; Reza Kazimi; Benard Poelker
2007-06-25
Fiber-based drive lasers now produce all of the spin-polarized electron beams at CEBAF/Jefferson Lab. The flexibility of these drive lasers, combined with the existing three-beam CEBAF photoinjector Chopper, provides a means to implement a beat frequency technique to produce long time intervals between individual electron microbunches (tens of nanoseconds) by merely varying the nominal 499 MHz drive laser frequency by < 20%. This submission describes the RF Laser modulator that uses a divider and heterodyne scheme to maintain coherence with the accelerator Master Oscillator (MO), while providing delay resolution in increments of 2ns. Some possible uses for such a beammore » are discussed as well as intended future development.« less
RF Energy Harvesting Peel-and-Stick Sensors
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lalau-Keraly, Christopher; Schwartz, David; Daniel, George
PARC, a Xerox Company, is developing a low-cost system of peel-and-stick wireless sensors that will enable widespread building environment sensor deployment with the potential to deliver up to 30% energy savings. The system is embodied by a set of RF hubs that provide power to the automatically located sensor nodes, and relays data wirelessly to the building management system (BMS). The sensor nodes are flexible electronic labels powered by rectified RF energy transmitted by a RF hub and can contain multiple printed and conventional sensors. The system design overcomes limitations in wireless sensors related to power delivery, lifetime, and costmore » by eliminating batteries and photovoltaic devices. The sensor localization is performed automatically by the inclusion of a programmable multidirectional antenna array in the RF hub. Comparison of signal strengths when the RF beam is swept allows for sensor localization, further reducing installation effort and enabling automatic recommissioning of sensors that have been relocated, overcoming a significant challenge in building operations. PARC has already demonstrated wireless power and temperature data transmission up to a distance of 20m with a duty cycle less than a minute between measurements, using power levels well within the FCC regulation limits in the 902-928 MHz ISM band. The sensor’s RF energy harvesting antenna dimensions was less than 5cmx9cm, demonstrating the possibility of small form factor for the sensor nodes.« less
1992-06-30
18-722, 1985. (b)N. Koshizuka, K. Ando, and T. Okuda, "Growth-Induced Birefringence in LPE - grown Iron Garnet Films ," in Proc. Int. Sy ,p...J. Martin, R. Wolf, R. C. LeCraw, and S. L. Black,"Switching and modulation of light in magneto-optic waveguides of garnet films ," Appl. Phys. Lett...in an Yttrium Iron Garnet Film ," Soy. Tech. Phys. Lett., Vol..1, pp.386-387, 1985. (c) A. A. Solomko. Yu. A. Gaidai, A. V. Dovzhenko, M. V
Li, Xinying; Yu, Jianjun; Chi, Nan; Zhang, Junwen
2013-11-15
We propose and experimentally demonstrate an optical wireless integration system at the Q-band, in which up to 40 Gb/s polarization multiplexing multilevel quadrature amplitude/phase modulation (PM-QAM) signal can be first transmitted over 20 km single-mode fiber-28 (SMF-28), then delivered over a 2 m 2 × 2 multiple-input multiple-output wireless link, and finally transmitted over another 20 km SMF-28. The PM-QAM modulated wireless millimeter-wave (mm-wave) signal at 40 GHz is generated based on the remote heterodyning technique, and demodulated by the radio-frequency transparent photonic technique based on homodyne coherent detection and baseband digital signal processing. The classic constant modulus algorithm equalization is used at the receiver to realize polarization demultiplexing of the PM-QAM signal. For the first time, to the best of our knowledge, we realize the conversion of the PM-QAM modulated wireless mm-wave signal to the optical signal as well as 20 km fiber transmission of the converted optical signal.
Devgan, Preetpaul S; Diehl, John F; Urick, Vincent J; Sunderman, Christopher E; Williams, Keith J
2009-05-25
We present a technique using a dual-output Mach-Zehnder modulator (MZM) with two wavelength inputs, one operating at low-bias and the other operating at high-bias, in order to cancel unwanted even-order harmonics in analog optical links. By using a dual-output MZM, this technique allows for two suppressed optical carriers to be transmitted to the receiver. Combined with optical amplification and balanced differential detection, the RF power of the fundamental is increased by 2 dB while the even-order harmonic is reduced by 47 dB, simultaneously. The RF noise figure and third-order spurious-free dynamic range (SFDR(3)) are improved by 5.4 dB and 3.6 dB, respectively. Using a wavelength sensitive, low V(pi) MZM allows the two wavelengths to be within 5.5 nm of each other for a frequency band from 10 MHz to 100 MHz and 10 nm for 1 GHz.
NASA Astrophysics Data System (ADS)
Hasan, Mehedi; Hall, Trevor
2016-11-01
In the title paper, Li et al. have presented a scheme for filter-less photonic millimetre-wave (mm-wave) generation based on two polarization multiplexed parallel dual-parallel Mach-Zehnder modulators (DP-MZMs). For frequency octo-tupling, all the harmonics are suppressed except those of order 4l, where l is the integer. The carrier is then suppressed by the polarization multiplexing technique, which is the principal innovative step in their design. Frequency 12-tupling and 16-tupling is also described following a similar method. The two DP-MZM are similarly driven and provide identical outputs for the same RF modulation indices. Consequently, a demerit of their design is the requirement to apply two different RF signal modulation indexes in a particular range and set the polarizer to a precise angle which depends on the pair of modulation indices used in order to suppress the unwanted harmonics (e.g. the carrier) without simultaneously suppressing the wanted harmonics. The aim of this comment is to show that, an adjustment of the RF drive phases with a fixed polarizer angle with the design presented by Li, all harmonics can be suppressed except those of order4l, where l is an odd integer. Hence, a filter-less frequency octo-tupling can be generated whose performance is not limited by the careful adjustment of the RF drive signal, rather it can be operated for a wide range of modulation indexes (m 2.5 → 7.5). If the modulation index is adjusted to suppress 4th harmonics, then the design can be used to perform frequency 24-tupling. Since, the carrier is suppressed by design in the modified architecture, the strict requirement to adjust the RF drive (and polarizer angle) can be avoided without any significant change to the circuit complexity.
UHF wearable battery free sensor module for activity and falling detection.
Nam Trung Dang; Thang Viet Tran; Wan-Young Chung
2016-08-01
Falling is one of the most serious medical and social problems in aging population. Therefore taking care of the elderly by detecting activity and falling for preventing and mitigating the injuries caused by falls needs to be concerned. This study proposes a wearable, wireless, battery free ultra-high frequency (UHF) smart sensor tag module for falling and activity detection. The proposed tag is powered by UHF RF wave from reader and read by a standard UHF Electronic Product Code (EPC) Class-1 Generation-2 reader. The battery free sensor module could improve the wearability of the wireless device. The combination of accelerometer signal and received signal strength indication (RSSI) from a reader in the passive smart sensor tag detect the activity and falling of the elderly very successfully. The fabricated smart sensor tag module has an operating range of up to 2.5m and conducting in real-time activity and falling detection.
A Versatile Multichannel Digital Signal Processing Module for Microcalorimeter Arrays
NASA Astrophysics Data System (ADS)
Tan, H.; Collins, J. W.; Walby, M.; Hennig, W.; Warburton, W. K.; Grudberg, P.
2012-06-01
Different techniques have been developed for reading out microcalorimeter sensor arrays: individual outputs for small arrays, and time-division or frequency-division or code-division multiplexing for large arrays. Typically, raw waveform data are first read out from the arrays using one of these techniques and then stored on computer hard drives for offline optimum filtering, leading not only to requirements for large storage space but also limitations on achievable count rate. Thus, a read-out module that is capable of processing microcalorimeter signals in real time will be highly desirable. We have developed multichannel digital signal processing electronics that are capable of on-board, real time processing of microcalorimeter sensor signals from multiplexed or individual pixel arrays. It is a 3U PXI module consisting of a standardized core processor board and a set of daughter boards. Each daughter board is designed to interface a specific type of microcalorimeter array to the core processor. The combination of the standardized core plus this set of easily designed and modified daughter boards results in a versatile data acquisition module that not only can easily expand to future detector systems, but is also low cost. In this paper, we first present the core processor/daughter board architecture, and then report the performance of an 8-channel daughter board, which digitizes individual pixel outputs at 1 MSPS with 16-bit precision. We will also introduce a time-division multiplexing type daughter board, which takes in time-division multiplexing signals through fiber-optic cables and then processes the digital signals to generate energy spectra in real time.
Alavash, Mohsen; Lim, Sung-Joo; Thiel, Christiane; Sehm, Bernhard; Deserno, Lorenz; Obleser, Jonas
2018-05-15
Dopamine underlies important aspects of cognition, and has been suggested to boost cognitive performance. However, how dopamine modulates the large-scale cortical dynamics during cognitive performance has remained elusive. Using functional MRI during a working memory task in healthy young human listeners, we investigated the effect of levodopa (l-dopa) on two aspects of cortical dynamics, blood oxygen-level-dependent (BOLD) signal variability and the functional connectome of large-scale cortical networks. We here show that enhanced dopaminergic signaling modulates the two potentially interrelated aspects of large-scale cortical dynamics during cognitive performance, and the degree of these modulations is able to explain inter-individual differences in l-dopa-induced behavioral benefits. Relative to placebo, l-dopa increased BOLD signal variability in task-relevant temporal, inferior frontal, parietal and cingulate regions. On the connectome level, however, l-dopa diminished functional integration across temporal and cingulo-opercular regions. This hypo-integration was expressed as a reduction in network efficiency and modularity in more than two thirds of the participants and to different degrees. Hypo-integration co-occurred with relative hyper-connectivity in paracentral lobule and precuneus, as well as posterior putamen. Both, l-dopa-induced BOLD signal variability modulation and functional connectome modulations proved predictive of an individual's l-dopa-induced benefits in behavioral performance, namely response speed and perceptual sensitivity. Lastly, l-dopa-induced modulations of BOLD signal variability were correlated with l-dopa-induced modulation of nodal connectivity and network efficiency. Our findings underline the role of dopamine in maintaining the dynamic range of, and communication between, cortical systems, and their explanatory power for inter-individual differences in benefits from dopamine during cognitive performance. Copyright © 2018
Tribotronic Tuning Diode for Active Analog Signal Modulation.
Zhou, Tao; Yang, Zhi Wei; Pang, Yaokun; Xu, Liang; Zhang, Chi; Wang, Zhong Lin
2017-01-24
Realizing active interaction with external environment/stimuli is a great challenge for current electronics. In this paper, a tribotronic tuning diode (TTD) is proposed by coupling a variable capacitance diode and a triboelectric nanogenerator in free-standing sliding mode. When the friction layer is sliding on the device surface for electrification, a reverse bias voltage is created and applied to the diode for tuning the junction capacitance. When the sliding distance increases from 0 to 25 mm, the capacitance of the TTD decreases from about 39 to 8 pF. The proposed TTD has been integrated into analog circuits and exhibited excellent performances in frequency modulation, phase shift, and filtering by sliding a finger. This work has demonstrated tunable diode and active analog signal modulation by tribotronics, which has great potential to replace ordinary variable capacitance diodes in various practical applications such as signal processing, electronic tuning circuits, precise tuning circuits, active sensor networks, electronic communications, remote controls, flexible electronics, etc.
Jumping the energetics queue: Modulation of pulsar signals by extraterrestrial civilizations
NASA Astrophysics Data System (ADS)
Chennamangalam, Jayanth; Siemion, Andrew P. V.; Lorimer, D. R.; Werthimer, Dan
2015-01-01
It has been speculated that technological civilizations evolve along an energy consumption scale first formulated by Kardashev, ranging from human-like civilizations that consume energy at a rate of ∼1019 erg s-1 to hypothetical highly advanced civilizations that can consume ∼1044 erg s-1. Since the transmission power of a beacon a civilization can build depends on the energy it possesses, to make it bright enough to be seen across the Galaxy would require high technological advancement. In this paper, we discuss the possibility of a civilization using naturally-occurring radio transmitters - specifically, radio pulsars - to overcome the Kardashev limit of their developmental stage and transmit super-Kardashev power. This is achieved by the use of a modulator situated around a pulsar, that modulates the pulsar signal, encoding information onto its natural emission. We discuss a simple modulation model using pulse nulling and considerations for detecting such a signal. We find that a pulsar with a nulling modulator will exhibit an excess of thermal emission peaking in the ultraviolet during its null phases, revealing the existence of a modulator.
Modulation of EEG Theta Band Signal Complexity by Music Therapy
NASA Astrophysics Data System (ADS)
Bhattacharya, Joydeep; Lee, Eun-Jeong
The primary goal of this study was to investigate the impact of monochord (MC) sounds, a type of archaic sounds used in music therapy, on the neural complexity of EEG signals obtained from patients undergoing chemotherapy. The secondary goal was to compare the EEG signal complexity values for monochords with those for progressive muscle relaxation (PMR), an alternative therapy for relaxation. Forty cancer patients were randomly allocated to one of the two relaxation groups, MC and PMR, over a period of six months; continuous EEG signals were recorded during the first and last sessions. EEG signals were analyzed by applying signal mode complexity, a measure of complexity of neuronal oscillations. Across sessions, both groups showed a modulation of complexity of beta-2 band (20-29Hz) at midfrontal regions, but only MC group showed a modulation of complexity of theta band (3.5-7.5Hz) at posterior regions. Therefore, the neuronal complexity patterns showed different changes in EEG frequency band specific complexity resulting in two different types of interventions. Moreover, the different neural responses to listening to monochords and PMR were observed after regular relaxation interventions over a short time span.
Harris, John Richardson; Caporaso, George J; Sampayan, Stephen E
2013-10-22
A system and method for producing modulated electrical signals. The system uses a variable resistor having a photoconductive wide bandgap semiconductor material construction whose conduction response to changes in amplitude of incident radiation is substantially linear throughout a non-saturation region to enable operation in non-avalanche mode. The system also includes a modulated radiation source, such as a modulated laser, for producing amplitude-modulated radiation with which to direct upon the variable resistor and modulate its conduction response. A voltage source and an output port, are both operably connected to the variable resistor so that an electrical signal may be produced at the output port by way of the variable resistor, either generated by activation of the variable resistor or propagating through the variable resistor. In this manner, the electrical signal is modulated by the variable resistor so as to have a waveform substantially similar to the amplitude-modulated radiation.
Lee, Youngbum; Kim, Jinkwon; Son, Muntak; Lee, Myoungho
2007-01-01
This research implements wireless accelerometer sensor module and algorithm to determine wearer's posture, activity and fall. Wireless accelerometer sensor module uses ADXL202, 2-axis accelerometer sensor (Analog Device). And using wireless RF module, this module measures accelerometer signal and shows the signal at ;Acceloger' viewer program in PC. ADL algorithm determines posture, activity and fall that activity is determined by AC component of accelerometer signal and posture is determined by DC component of accelerometer signal. Those activity and posture include standing, sitting, lying, walking, running, etc. By the experiment for 30 subjects, the performance of implemented algorithm was assessed, and detection rate for postures, motions and subjects was calculated. Lastly, using wireless sensor network in experimental space, subject's postures, motions and fall monitoring system was implemented. By the simulation experiment for 30 subjects, 4 kinds of activity, 3 times, fall detection rate was calculated. In conclusion, this system can be application to patients and elders for activity monitoring and fall detection and also sports athletes' exercise measurement and pattern analysis. And it can be expected to common person's exercise training and just plaything for entertainment.
Compact rf polarizer and its application to pulse compression systems
Franzi, Matthew; Wang, Juwen; Dolgashev, Valery; ...
2016-06-01
We present a novel method of reducing the footprint and increasing the efficiency of the modern multi-MW rf pulse compressor. This system utilizes a high power rf polarizer to couple two circular waveguide modes in quadrature to a single resonant cavity in order to replicate the response of a traditional two cavity configuration using a 4-port hybrid. The 11.424 GHz, high-Q, spherical cavity has a 5.875 cm radius and is fed by the circularly polarized signal to simultaneously excite the degenerate TE 114 modes. The overcoupled spherical cavity has a Q 0 of 9.4×10 4 and coupling factor (β) ofmore » 7.69 thus providing a loaded quality factor Q L of 1.06×10 4 with a fill time of 150 ns. Cold tests of the polarizer demonstrated good agreement with the numerical design, showing transmission of -0.05 dB and reflection back to the input rectangular WR 90 waveguide less than -40 dB over a 100 MHz bandwidth. This novel rf pulse compressor was tested at SLAC using XL-4 Klystron that provided rf power up to 32 MW and generated peak output power of 205 MW and an average of 135 MW over the discharged signal. A general network analysis of the polarizer is discussed as well as the design and high power test of the rf pulse compressor.« less
CFTR modulates RPS27 gene expression using chloride anion as signaling effector.
Valdivieso, Ángel G; Mori, Consuelo; Clauzure, Mariángeles; Massip-Copiz, Macarena; Santa-Coloma, Tomás A
2017-11-01
In Cystic Fibrosis (CF), the impairment of the CFTR channel activity leads to a variety of alterations, including differential gene expression. However, the CFTR signaling mechanisms remain unclear. Recently, culturing IB3-1 CF cells under different intracellular Cl - concentrations ([Cl - ] i ), we observed several Cl - -dependent genes and further characterized one of them as RPS27. Thus, we hypothesized that Cl - might act as a signaling effector for CFTR signaling. Here, to test this idea, we study RPS27 expression in T84 cells modulating the CFTR activity by using CFTR inhibitors. First, we observed that incubation of T84 cells with increasing concentrations of the CFTR inhibitors CFTR(inh)-172 or GlyH-101 determined a progressive increase in the relative [Cl - ] i (using the Cl - fluorescent probe SPQ). The [Cl - ] i rise was concomitant with a dose-dependent down-regulation of RPS27. These results imply that CFTR inhibition produce Cl - accumulation and that RPS27 expression can be modulated by CFTR inhibition. Therefore, Cl - behaves as a signaling effector for CFTR in the modulation of RPS27 expression. In addition, the IL-1β receptor antagonist IL1RN or the JNK inhibitor SP600125, both restored the down-regulation of RPS27 induced by CFTRinh-172, implying a role of autocrine IL-1β and JNK signaling downstream of Cl - in RPS27 modulation. Copyright © 2017 Elsevier Inc. All rights reserved.
Genetic variation in glia-neuron signalling modulates ageing rate.
Yin, Jiang-An; Gao, Ge; Liu, Xi-Juan; Hao, Zi-Qian; Li, Kai; Kang, Xin-Lei; Li, Hong; Shan, Yuan-Hong; Hu, Wen-Li; Li, Hai-Peng; Cai, Shi-Qing
2017-11-08
The rate of behavioural decline in the ageing population is remarkably variable among individuals. Despite the considerable interest in studying natural variation in ageing rate to identify factors that control healthy ageing, no such factor has yet been found. Here we report a genetic basis for variation in ageing rates in Caenorhabditis elegans. We find that C. elegans isolates show diverse lifespan and age-related declines in virility, pharyngeal pumping, and locomotion. DNA polymorphisms in a novel peptide-coding gene, named regulatory-gene-for-behavioural-ageing-1 (rgba-1), and the neuropeptide receptor gene npr-28 influence the rate of age-related decline of worm mating behaviour; these two genes might have been subjected to recent selective sweeps. Glia-derived RGBA-1 activates NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration. This signalling involves the SIR-2.1-dependent activation of the mitochondrial unfolded protein response, a pathway that modulates ageing. Thus, natural variation in neuropeptide-mediated glia-neuron signalling modulates the rate of ageing in C. elegans.
Orphan nuclear receptor TLX regulates astrogenesis by modulating BMP signaling.
Qin, Song; Niu, Wenze; Iqbal, Nida; Smith, Derek K; Zhang, Chun-Li
2014-01-01
Neural stem cells (NSCs) are self-renewing multipotent progenitors that generate both neurons and glia. The precise control of NSC behavior is fundamental to the architecture and function of the central nervous system. We previously demonstrated that the orphan nuclear receptor TLX is required for postnatal NSC activation and neurogenesis in the neurogenic niche. Here, we show that TLX modulates bone morphogenetic protein (BMP)-SMAD signaling to control the timing of postnatal astrogenesis. Genes involved in the BMP signaling pathway, such as Bmp4, Hes1, and Id3, are upregulated in postnatal brains lacking Tlx. Chromatin immunoprecipitation and electrophoretic mobility shift assays reveal that TLX can directly bind the enhancer region of Bmp4. In accordance with elevated BMP signaling, the downstream effectors SMAD1/5/8 are activated by phosphorylation in Tlx mutant mice. Consequently, Tlx mutant brains exhibit an early appearance and increased number of astrocytes with marker expression of glial fibrillary acidic protein (GFAP) and S100B. Taken together, these results suggest that TLX tightly controls postnatal astrogenesis through the modulation of BMP-SMAD signaling pathway activity.
The 2D analytic signal for envelope detection and feature extraction on ultrasound images.
Wachinger, Christian; Klein, Tassilo; Navab, Nassir
2012-08-01
The fundamental property of the analytic signal is the split of identity, meaning the separation of qualitative and quantitative information in form of the local phase and the local amplitude, respectively. Especially the structural representation, independent of brightness and contrast, of the local phase is interesting for numerous image processing tasks. Recently, the extension of the analytic signal from 1D to 2D, covering also intrinsic 2D structures, was proposed. We show the advantages of this improved concept on ultrasound RF and B-mode images. Precisely, we use the 2D analytic signal for the envelope detection of RF data. This leads to advantages for the extraction of the information-bearing signal from the modulated carrier wave. We illustrate this, first, by visual assessment of the images, and second, by performing goodness-of-fit tests to a Nakagami distribution, indicating a clear improvement of statistical properties. The evaluation is performed for multiple window sizes and parameter estimation techniques. Finally, we show that the 2D analytic signal allows for an improved estimation of local features on B-mode images. Copyright © 2012 Elsevier B.V. All rights reserved.
Measured thermal images of a gallium arsenide power MMIC with and without RF applied to the input
NASA Astrophysics Data System (ADS)
Oxley, C. H.; Coaker, B. M.; Priestley, N. E.
2003-04-01
A gallium arsenide microwave monolithic integrated circuit (MMIC) power amplifier (M/ACom type MAAM71100) has been measured using infra-red microscope technology, with and without the application of a RF input signal. A reduction of approximately 10 °C in chip temperature was observed with the application of a RF input signal, which will influence the MTTF of the chip. Further, the measurement technique may be used to monitor the thermal impedance and dynamic cooling of RF power devices under operational conditions in complex circuits.
1995 second modulator-klystron workshop: A modulator-klystron workshop for future linear colliders
DOE Office of Scientific and Technical Information (OSTI.GOV)
NONE
1996-03-01
This second workshop examined the present state of modulator design and attempted an extrapolation for future electron-positron linear colliders. These colliders are currently viewed as multikilometer-long accelerators consisting of a thousand or more RF sources with 500 to 1,000, or more, pulsed power systems. The workshop opened with two introductory talks that presented the current approaches to designing these linear colliders, the anticipated RF sources, and the design constraints for pulse power. The cost of main AC power is a major economic consideration for a future collider, consequently the workshop investigated efficient modulator designs. Techniques that effectively apply the artmore » of power conversion, from the AC mains to the RF output, and specifically, designs that generate output pulses with very fast rise times as compared to the flattop. There were six sessions that involved one or more presentations based on problems specific to the design and production of thousands of modulator-klystron stations, followed by discussion and debate on the material.« less
The DAN family: modulators of TGF-β signaling and beyond.
Nolan, Kristof; Thompson, Thomas B
2014-08-01
Extracellular binding proteins or antagonists are important factors that modulate ligands in the transforming growth factor (TGF-β) family. While the interplay between antagonists and ligands are essential for developmental and normal cellular processes, their imbalance can lead to the pathology of several disease states. In particular, recent studies have implicated members of the differential screening-selected gene in neuroblastoma (DAN) family in disease such as renal fibrosis, pulmonary arterial hypertension, and reactivation of metastatic cancer stem cells. DAN family members are known to inhibit the bone morphogenetic proteins (BMP) of the TGF-β family. However, unlike other TGF-β antagonist families, DAN family members have roles beyond ligand inhibition and can modulate Wnt and vascular endothelial growth factor (VEGF) signaling pathways. This review describes recent structural and functional advances that have expanded our understanding of DAN family proteins with regards to BMP inhibition and also highlights their emerging roles in the modulation of Wnt and VEGF signaling pathways. © 2014 The Protein Society.
Generation of ultra-wide and flat optical frequency comb based on electro absorption modulator
NASA Astrophysics Data System (ADS)
Ujjwal; Thangaraj, Jaisingh
2018-05-01
A novel technique is proposed for the generation of ultra-wide and flat optical frequency comb (OFC) based on serially cascading three stages of electro absorption modulators (EAMs) through sinusoidal radio frequency (RF) signals by setting frequencies at f GHz, f/2 GHz and f/4 GHz. Here, the first stage acts as subcarrier generator, the second stage acts as subcarrier doubler, and the third stage acts as subcarrier quadrupler. In addition, a higher number of subcarriers can easily be generated by adjusting the driving sinusoidal RF signal. In this paper, cascading three stages of EAMs driven by 50 GHz, 25 GHz and 12.5 GHz clock sources, we obtain 272 subcarriers with spacing of 2.5 GHz and power deviation within 1 dB. Theoretical analysis of serially cascaded EAMs for subcarrier generation is also investigated. Principal analysis and simulation of this technique are demonstrated.
Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.
Kunnumakkara, Ajaikumar B; Bordoloi, Devivasha; Harsha, Choudhary; Banik, Kishore; Gupta, Subash C; Aggarwal, Bharat B
2017-08-01
Curcumin, a component of a spice native to India, was first isolated in 1815 by Vogel and Pelletier from the rhizomes of Curcuma longa (turmeric) and, subsequently, the chemical structure of curcumin as diferuloylmethane was reported by Milobedzka et al. [(1910) 43., 2163-2170]. Since then, this polyphenol has been shown to exhibit antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antifungal activities. The current review primarily focuses on the anticancer potential of curcumin through the modulation of multiple cell signaling pathways. Curcumin modulates diverse transcription factors, inflammatory cytokines, enzymes, kinases, growth factors, receptors, and various other proteins with an affinity ranging from the pM to the mM range. Furthermore, curcumin effectively regulates tumor cell growth via modulation of numerous cell signaling pathways and potentiates the effect of chemotherapeutic agents and radiation against cancer. Curcumin can interact with most of the targets that are modulated by FDA-approved drugs for cancer therapy. The focus of this review is to discuss the molecular basis for the anticancer activities of curcumin based on preclinical and clinical findings. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
Model cerebellar granule cells can faithfully transmit modulated firing rate signals
Rössert, Christian; Solinas, Sergio; D'Angelo, Egidio; Dean, Paul; Porrill, John
2014-01-01
A crucial assumption of many high-level system models of the cerebellum is that information in the granular layer is encoded in a linear manner. However, granule cells are known for their non-linear and resonant synaptic and intrinsic properties that could potentially impede linear signal transmission. In this modeling study we analyse how electrophysiological granule cell properties and spike sampling influence information coded by firing rate modulation, assuming no signal-related, i.e., uncorrelated inhibitory feedback (open-loop mode). A detailed one-compartment granule cell model was excited in simulation by either direct current or mossy-fiber synaptic inputs. Vestibular signals were represented as tonic inputs to the flocculus modulated at frequencies up to 20 Hz (approximate upper frequency limit of vestibular-ocular reflex, VOR). Model outputs were assessed using estimates of both the transfer function, and the fidelity of input-signal reconstruction measured as variance-accounted-for. The detailed granule cell model with realistic mossy-fiber synaptic inputs could transmit information faithfully and linearly in the frequency range of the vestibular-ocular reflex. This was achieved most simply if the model neurons had a firing rate at least twice the highest required frequency of modulation, but lower rates were also adequate provided a population of neurons was utilized, especially in combination with push-pull coding. The exact number of neurons required for faithful transmission depended on the precise values of firing rate and noise. The model neurons were also able to combine excitatory and inhibitory signals linearly, and could be replaced by a simpler (modified) integrate-and-fire neuron in the case of high tonic firing rates. These findings suggest that granule cells can in principle code modulated firing-rate inputs in a linear manner, and are thus consistent with the high-level adaptive-filter model of the cerebellar microcircuit. PMID:25352777
NASA Astrophysics Data System (ADS)
Luan, P.; Knoll, A. J.; Wang, H.; Kondeti, V. S. S. K.; Bruggeman, P. J.; Oehrlein, G. S.
2017-01-01
The surface interaction of a well-characterized time modulated radio frequency (RF) plasma jet with polystyrene, poly(methyl methacrylate) and poly(vinyl alcohol) as model polymers is investigated. The RF plasma jet shows fast polymer etching but mild chemical modification with a characteristic carbonate ester and NO formation on the etched surface. By varying the plasma treatment conditions including feed gas composition, environment gaseous composition, and treatment distance, we find that short lived species, especially atomic O for Ar/1% O2 and 1% air plasma and OH for Ar/1% H2O plasma, play an essential role for polymer etching. For O2 containing plasma, we find that atomic O initiates polymer etching and the etching depth mirrors the measured decay of O atoms in the gas phase as the nozzle-surface distance increases. The etching reaction probability of an O atom ranging from 10-4 to 10-3 is consistent with low pressure plasma research. We also find that adding O2 and H2O simultaneously into Ar feed gas quenches polymer etching compared to adding them separately which suggests the reduction of O and OH density in Ar/O2/H2O plasma.
Signal modulation as a mechanism for handicap disposal
Gavassa, Sat; Silva, Ana C.; Gonzalez, Emmanuel; Stoddard, Philip K.
2012-01-01
Signal honesty may be compromised when heightened competition provides incentive for signal exaggeration. Some degree of honesty might be maintained by intrinsic handicap costs on signalling or through imposition of extrinsic costs, such as social punishment of low quality cheaters. Thus, theory predicts a delicate balance between signal enhancement and signal reliability that varies with degree of social competition, handicap cost, and social cost. We investigated whether male sexual signals of the electric fish Brachyhypopomus gauderio would become less reliable predictors of body length when competition provides incentives for males to boost electric signal amplitude. As expected, social competition under natural field conditions and in controlled lab experiments drove males to enhance their signals. However, signal enhancement improved the reliability of the information conveyed by the signal, as revealed in the tightening of the relationship between signal amplitude and body length. Signal augmentation in male B. gauderio was independent of body length, and thus appeared not to be curtailed through punishment of low quality (small) individuals. Rather, all individuals boosted their signals under high competition, but those whose signals were farthest from the predicted value under low competition boosted signal amplitude the most. By elimination, intrinsic handicap cost of signal production, rather than extrinsic social cost, appears to be the basis for the unexpected reinforcement of electric signal honesty under social competition. Signal modulation may provide its greatest advantage to the signaller as a mechanism for handicap disposal under low competition rather than as a mechanism for exaggeration of quality under high competition. PMID:22665940
Methods and devices based on brillouin selective sideband amplification
NASA Technical Reports Server (NTRS)
Yao, X. Steve (Inventor)
2003-01-01
Opto-electronic devices and techniques using Brillouin scattering to select a sideband in a modulated optical carrier signal for amplification. Two lasers respectively provide a carrier signal beam and a Brillouin pump beam which are fed into an Brillouin optical medium in opposite directions. The relative frequency separation between the lasers is adjusted to align the frequency of the backscattered Brillouin signal with a desired sideband in the carrier signal to effect a Brillouin gain on the sideband. This effect can be used to implement photonic RF signal mixing and conversion with gain, conversion from phase modulation to amplitude modulation, photonic RF frequency multiplication, optical and RF pulse generation and manipulation, and frequency-locking of lasers.
Rate change detection of frequency modulated signals: developmental trends.
Cohen-Mimran, Ravit; Sapir, Shimon
2011-08-26
The aim of this study was to examine developmental trends in rate change detection of auditory rhythmic signals (repetitive sinusoidally frequency modulated tones). Two groups of children (9-10 years old and 11-12 years old) and one group of young adults performed a rate change detection (RCD) task using three types of stimuli. The rate of stimulus modulation was either constant (CR), raised by 1 Hz in the middle of the stimulus (RR1) or raised by 2 Hz in the middle of the stimulus (RR2). Performance on the RCD task significantly improved with age. Also, the different stimuli showed different developmental trajectories. When the RR2 stimulus was used, results showed adult-like performance by the age of 10 years but when the RR1 stimulus was used performance continued to improve beyond 12 years of age. Rate change detection of repetitive sinusoidally frequency modulated tones show protracted development beyond the age of 12 years. Given evidence for abnormal processing of auditory rhythmic signals in neurodevelopmental conditions, such as dyslexia, the present methodology might help delineate the nature of these conditions.
NASA Astrophysics Data System (ADS)
Berneking, Arne; Trinchero, Riccardo; Ha, YongHyun; Finster, Felix; Cerello, Piergiorgio; Lerche, Christoph; Shah, Nadim Jon
2017-05-01
This paper focuses on the design and the characterization of a frequency-selective shield for positron emission tomography (PET) detector modules of hybrid magnetic resonance-PET scanners, where the shielding of the PET cassettes is located close to the observed object. The proposed shielding configuration is designed and optimized to guarantee a high shielding effectiveness (SE) of up to 60 dB for B1-fields at the Larmor frequency of 64 MHz, thus preventing interactions between the radio-frequency (RF) coil and PET electronics. On the other hand, the shield is transparent to the gradient fields with the consequence that eddy-current artifacts in the acquired EPI images are significantly reduced with respect to the standard solid-shield configuration. The frequency-selective behavior of the shield is characterized and validated via simulation studies with CST MICROWAVE STUDIO in the megahertz and kilohertz range. Bench measurements with an RF coil built in-house demonstrated the high SE at the Larmor frequency. Moreover, measurements on a 4-T human scanner confirmed the abolishment of eddy current artifact and also provided an understanding of where the eddy currents occur with respect to the sequence parameters. Simulations and measurements for the proposed shielding concept were compared with a solid copper shielding configuration.
Coco is a dual activity modulator of TGFβ signaling
Deglincerti, Alessia; Haremaki, Tomomi; Warmflash, Aryeh; Sorre, Benoit; Brivanlou, Ali H.
2015-01-01
The TGFβ signaling pathway is a crucial regulator of developmental processes and disease. The activity of TGFβ ligands is modulated by various families of soluble inhibitors that interfere with the interactions between ligands and receptors. In an unbiased, genome-wide RNAi screen to identify genes involved in ligand-dependent signaling, we unexpectedly identified the BMP/Activin/Nodal inhibitor Coco as an enhancer of TGFβ1 signaling. Coco synergizes with TGFβ1 in both cell culture and Xenopus explants. Molecularly, Coco binds to TGFβ1 and enhances TGFβ1 binding to its receptor Alk5. Thus, Coco acts as both an inhibitor and an enhancer of signaling depending on the ligand it binds. This finding raises the need for a global reconsideration of the molecular mechanisms regulating TGFβ signaling. PMID:26116664
RF-DC converter for HF RFID sensing applications powered by a near-field loop antenna
NASA Astrophysics Data System (ADS)
Colella, R.; Pasca, M.; Catarinucci, L.; Tarricone, L.; D'Amico, S.
2016-07-01
In this paper, an RF-DC converter operating at 13.56 MHz (HF radio frequency identification (RFID) frequency band) is presented. Its architecture provides RF to load isolation, reducing the losses due to the reverse saturation current and improving the sensitivity. Fed by a loop antenna, the RF-DC converter is made by a Dickson's RF-DC rectifier and an additional Pelliconi's charge pump driven by a fully integrated 50 kHz ring oscillator realized using an application-specific integrated circuit (ASIC). The input RF signal from the reader is converted to DC supply voltage and stored on a 1 μF capacitor. Mathematical model of the converter is developed and verified through measurements. Silicon prototypes of the ASIC have been realized in 350 nm complementary metal-oxide semiconductor technology. Measurements have been done on 10 different samples showing an output voltage in the range of 0.5 V-3.11 V in correspondence of an RF input signal power in the range of -19 dBm-0 dBm. These output voltage levels are suitable to power HF RFID sensing platforms and sensor nodes of body sensor networks.
Rodenbeck, Christopher T.; Tracey, Keith J.; Barkley, Keith R.; ...
2014-08-01
This paper introduces a technique for improving the sensitivity of RF subsamplers in radar and coherent receiver applications. The technique, referred to herein as “delta modulation” (DM), feeds the time-average output of a monobit analog-to-digital converter (ADC) back to the ADC input, but with opposite polarity. Assuming pseudo-stationary modulation statistics on the sampled RF waveform, the feedback signal corrects for aggregate DC offsets present in the ADC that otherwise degrade ADC sensitivity. Two RF integrated circuits (RFICs) are designed to demonstrate the approach. One uses analog DM to create the feedback signal; the other uses digital DM to achieve themore » same result. A series of tests validates the designs. The dynamic time-domain response confirms the feedback loop’s basic operation. Measured output quantization imbalance, under noise-only input drive, significantly improves with the use of the DM circuit, even for large, deliberately induced DC offsets and wide temperature variation from -55°C to +85 °C. Examination of the corrected vs. uncorrected baseband spectrum under swept input signal-tonoise ratio (SNR) conditions demonstrates the effectiveness of this approach for realistic radar and coherent receiver applications. In conclusion, two-tone testing shows no impact of the DM technique on ADC linearity.« less
Micropower RF transponder with superregenerative receiver and RF receiver with sampling mixer
McEwan, Thomas E.
1997-01-01
A micropower RF transdponder employs a novel adaptation of the superregenerative receiver wherein the quench oscillator is external to the regenerative transistor. The quench oscillator applies an exponentially decaying waveform rather than the usual sinewave to achieve high sensitivity at microampere current levels. Further improvements include circuit simplifications for antenna coupling, extraction of the detected signal, and a low-voltage bias configuration that allows operation with less than a 1-volt rail voltage. The inventive transponder is expected to operate as long as the battery shelf life.
Simple method for RF pulse measurement using gradient reversal.
Landes, Vanessa L; Nayak, Krishna S
2018-05-01
To develop and evaluate a simple method for measuring the envelope of small-tip radiofrequency (RF) excitation waveforms in MRI, without extra hardware or synchronization. Gradient reversal approach to evaluate RF (GRATER) involves RF excitation with a constant gradient and reversal of that gradient during signal reception to acquire the time-reversed version of an RF envelope. An outer-volume suppression prepulse is used optionally to preselect a uniform volume. GRATER was evaluated in phantom and in vivo experiments. It was compared with the programmed waveform and the traditional pick-up coil method. In uniform phantom experiments, pick-up coil, GRATER, and outer-volume suppression + GRATER matched the programmed waveforms to less than 2.1%, less than 6.1%, and less than 2.4% normalized root mean square error, respectively, for real RF pulses with flip angle less than or equal to 30°, time-bandwidth product 2 to 8, and two to five excitation bands. For flip angles greater than 30°, GRATER measurement error increased as predicted by Bloch simulation. Fat-water phantom and in vivo experiments with outer-volume suppression + GRATER demonstrated less than 6.4% normalized root mean square error. The GRATER sequence measures small-tip RF envelopes without extra hardware or synchronization in just over two times the RF duration. The sequence may be useful in prescan calibration and for measurement and precompensation of RF amplifier nonlinearity. Magn Reson Med 79:2642-2651, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.
Automatic pattern identification of rock moisture based on the Staff-RF model
NASA Astrophysics Data System (ADS)
Zheng, Wei; Tao, Kai; Jiang, Wei
2018-04-01
Studies on the moisture and damage state of rocks generally focus on the qualitative description and mechanical information of rocks. This method is not applicable to the real-time safety monitoring of rock mass. In this study, a musical staff computing model is used to quantify the acoustic emission signals of rocks with different moisture patterns. Then, the random forest (RF) method is adopted to form the staff-RF model for the real-time pattern identification of rock moisture. The entire process requires only the computing information of the AE signal and does not require the mechanical conditions of rocks.
Wei, J L; Hugues-Salas, E; Giddings, R P; Jin, X Q; Zheng, X; Mansoor, S; Tang, J M
2010-05-10
Detailed numerical investigations are undertaken of wavelength reused bidirectional transmission of adaptively modulated optical OFDM (AMOOFDM) signals over a single SMF in a colorless WDM-PON incorporating a semiconductor optical amplifier (SOA) intensity modulator and a reflective SOA (RSOA) intensity modulator in the optical line termination and optical network unit, respectively. A comprehensive theoretical model describing the performance of such network scenarios is, for the first time, developed, taking into account dynamic optical characteristics of SOA and RSOA intensity modulators as well as the effects of Rayleigh backscattering (RB) and residual downstream signal-induced crosstalk. The developed model is rigorously verified experimentally in RSOA-based real-time end-to-end OOFDM systems at 7.5 Gb/s. It is shown that the RB noise and crosstalk effects are dominant factors limiting the maximum achievable downstream and upstream transmission performance. Under optimum SOA and RSOA operating conditions as well as practical downstream and upstream optical launch powers, 10 Gb/s downstream and 6 Gb/s upstream over 40 km SMF transmissions of conventional double sideband AMOOFDM signals are feasible without utilizing in-line optical amplification and chromatic dispersion compensation. In particular, the aforementioned transmission performance can be improved to 23 Gb/s downstream and 8 Gb/s upstream over 40 km SMFs when single sideband subcarrier modulation is adopted in the downstream systems. (c) 2010 Optical Society of America.
RF Conditioning of the Photo-Cathode RF Gun at the Advanced Photon Source - NWA RF Measurements
DOE Office of Scientific and Technical Information (OSTI.GOV)
Smith, T. L.; DiMonte, N.; Nassiri, A.
A new S-band Photo-cathode (PC) gun was recently installed and RF conditioned at the Advanced Photon Source (APS) Injector Test-stand (ITS) at Argonne National Lab (ANL). The APS PC gun is a LCLS type gun fabricated at SLAC [1]. The PC gun was delivered to the APS in October 2013 and installed in the APS ITS in December 2013. At ANL, we developed a new method of fast detection and mitigation of the guns internal arcs during the RF conditioning process to protect the gun from arc damage and to RF condition more efficiently. Here, we report the results ofmore » RF measurements for the PC gun and an Auto-Restart method for high power RF conditioning.« less
Wideband aperture array using RF channelizers and massively parallel digital 2D IIR filterbank
NASA Astrophysics Data System (ADS)
Sengupta, Arindam; Madanayake, Arjuna; Gómez-García, Roberto; Engeberg, Erik D.
2014-05-01
Wideband receive-mode beamforming applications in wireless location, electronically-scanned antennas for radar, RF sensing, microwave imaging and wireless communications require digital aperture arrays that offer a relatively constant far-field beam over several octaves of bandwidth. Several beamforming schemes including the well-known true time-delay and the phased array beamformers have been realized using either finite impulse response (FIR) or fast Fourier transform (FFT) digital filter-sum based techniques. These beamforming algorithms offer the desired selectivity at the cost of a high computational complexity and frequency-dependant far-field array patterns. A novel approach to receiver beamforming is the use of massively parallel 2-D infinite impulse response (IIR) fan filterbanks for the synthesis of relatively frequency independent RF beams at an order of magnitude lower multiplier complexity compared to FFT or FIR filter based conventional algorithms. The 2-D IIR filterbanks demand fast digital processing that can support several octaves of RF bandwidth, fast analog-to-digital converters (ADCs) for RF-to-bits type direct conversion of wideband antenna element signals. Fast digital implementation platforms that can realize high-precision recursive filter structures necessary for real-time beamforming, at RF radio bandwidths, are also desired. We propose a novel technique that combines a passive RF channelizer, multichannel ADC technology, and single-phase massively parallel 2-D IIR digital fan filterbanks, realized at low complexity using FPGA and/or ASIC technology. There exists native support for a larger bandwidth than the maximum clock frequency of the digital implementation technology. We also strive to achieve More-than-Moore throughput by processing a wideband RF signal having content with N-fold (B = N Fclk/2) bandwidth compared to the maximum clock frequency Fclk Hz of the digital VLSI platform under consideration. Such increase in bandwidth is
NASA Astrophysics Data System (ADS)
Deng, Ning
In recent years, optical phase modulation has attracted much research attention in the field of fiber optic communications. Compared with the traditional optical intensity-modulated signal, one of the main merits of the optical phase-modulated signal is the better transmission performance. For optical phase modulation, in spite of the comprehensive study of its transmission performance, only a little research has been carried out in terms of its functions, applications and signal processing for future optical networks. These issues are systematically investigated in this thesis. The research findings suggest that optical phase modulation and its signal processing can greatly facilitate flexible network functions and high bandwidth which can be enjoyed by end users. In the thesis, the most important physical-layer technology, signal processing and multiplexing, are investigated with optical phase-modulated signals. Novel and advantageous signal processing and multiplexing approaches are proposed and studied. Experimental investigations are also reported and discussed in the thesis. Optical time-division multiplexing and demultiplexing. With the ever-increasing demand on communication bandwidth, optical time division multiplexing (OTDM) is an effective approach to upgrade the capacity of each wavelength channel in current optical systems. OTDM multiplexing can be simply realized, however, the demultiplexing requires relatively complicated signal processing and stringent timing control, and thus hinders its practicability. To tackle this problem, in this thesis a new OTDM scheme with hybrid DPSK and OOK signals is proposed. Experimental investigation shows this scheme can greatly enhance the demultiplexing timing misalignment and improve the demultiplexing performance, and thus make OTDM more practical and cost effective. All-optical signal processing. In current and future optical communication systems and networks, the data rate per wavelength has been approaching
Orphan nuclear receptor TLX regulates astrogenesis by modulating BMP signaling
Qin, Song; Niu, Wenze; Iqbal, Nida; Smith, Derek K.; Zhang, Chun-Li
2014-01-01
Neural stem cells (NSCs) are self-renewing multipotent progenitors that generate both neurons and glia. The precise control of NSC behavior is fundamental to the architecture and function of the central nervous system. We previously demonstrated that the orphan nuclear receptor TLX is required for postnatal NSC activation and neurogenesis in the neurogenic niche. Here, we show that TLX modulates bone morphogenetic protein (BMP)-SMAD signaling to control the timing of postnatal astrogenesis. Genes involved in the BMP signaling pathway, such as Bmp4, Hes1, and Id3, are upregulated in postnatal brains lacking Tlx. Chromatin immunoprecipitation and electrophoretic mobility shift assays reveal that TLX can directly bind the enhancer region of Bmp4. In accordance with elevated BMP signaling, the downstream effectors SMAD1/5/8 are activated by phosphorylation in Tlx mutant mice. Consequently, Tlx mutant brains exhibit an early appearance and increased number of astrocytes with marker expression of glial fibrillary acidic protein (GFAP) and S100B. Taken together, these results suggest that TLX tightly controls postnatal astrogenesis through the modulation of BMP-SMAD signaling pathway activity. PMID:24782704
RF-SABRE: A Way to Continuous Spin Hyperpolarization at High Magnetic Fields.
Pravdivtsev, Andrey N; Yurkovskaya, Alexandra V; Vieth, Hans-Martin; Ivanov, Konstantin L
2015-10-29
A new technique is developed that allows one to carry out the signal amplification by reversible exchange (SABRE) experiments at high magnetic field. SABRE is a hyperpolarization method, which utilizes transfer of spin order from para-hydrogen to the spins of a substrate in transient iridium complexes. Previously, it has been thought that such a transfer of spin order is only efficient at low magnetic fields, notably, at level anti-crossing (LAC) regions. Here it is demonstrated that LAC conditions can also be fulfilled at high fields under the action of a RF field. The high-field RF-SABRE experiment can be implemented using commercially available nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) machines and does not require technically demanding field-cycling. The achievable NMR enhancements are around 100 for several substrates as compared to their NMR signals at thermal equilibrium conditions at 4.7 T. The frequency dependence of RF-SABRE is comprised of well pronounced peaks and dips, whose position and amplitude are conditioned solely by the magnetic resonance parameters such as chemical shifts and scalar coupling of the spin system involved in the polarization transfer and by the amplitude of the RF field. Thus, the proposed method can serve as a new sensitive tool for probing transient complexes. Simulations of the dependence of magnetization transfer (i.e., NMR signal amplifications) on the frequency and amplitude of the RF field are in good agreement with the developed theoretical approach. Furthermore, the method enables continuous re-hyperpolarization of the SABRE substrate over a long period of time, giving a straightforward way to repetitive NMR experiments.
NASA Astrophysics Data System (ADS)
Lee, Hwan; Cho, Jun-Hyung; Sung, Hyuk-Kee
2017-05-01
The phase modulation (PM) and amplitude modulation (AM) of optical signals can be achieved using a direct-modulated (DM) optical injection-locked (OIL) semiconductor laser. We propose and theoretically analyze a simple method to extract the phase component of a PM signal produced by a DM-OIL semiconductor laser. The pure AM component of the combined PM-AM signal can be isolated by square-law detection in a photodetector and can then be used to compensate for the PM-AM signal based on an optical homodyne method. Using the AM compensation technique, we successfully developed a simple and cost-effective phase extraction method applicable to the PM-AM optical signal of a DM-OIL semiconductor laser.
Structural insights into eRF3 and stop codon recognition by eRF1
Cheng, Zhihong; Saito, Kazuki; Pisarev, Andrey V.; Wada, Miki; Pisareva, Vera P.; Pestova, Tatyana V.; Gajda, Michal; Round, Adam; Kong, Chunguang; Lim, Mengkiat; Nakamura, Yoshikazu; Svergun, Dmitri I.; Ito, Koichi; Song, Haiwei
2009-01-01
Eukaryotic translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act cooperatively to ensure efficient stop codon recognition and fast polypeptide release. The crystal structures of human and Schizosaccharomyces pombe full-length eRF1 in complex with eRF3 lacking the GTPase domain revealed details of the interaction between these two factors and marked conformational changes in eRF1 that occur upon binding to eRF3, leading eRF1 to resemble a tRNA molecule. Small-angle X-ray scattering analysis of the eRF1/eRF3/GTP complex suggested that eRF1's M domain contacts eRF3's GTPase domain. Consistently, mutation of Arg192, which is predicted to come in close contact with the switch regions of eRF3, revealed its important role for eRF1's stimulatory effect on eRF3's GTPase activity. An ATP molecule used as a crystallization additive was bound in eRF1's putative decoding area. Mutational analysis of the ATP-binding site shed light on the mechanism of stop codon recognition by eRF1. PMID:19417105
Thermo-Acoustic Ultrasound for Detection of RF-Induced Device Lead Heating in MRI.
Dixit, Neerav; Stang, Pascal P; Pauly, John M; Scott, Greig C
2018-02-01
Patients who have implanted medical devices with long conductive leads are often restricted from receiving MRI scans due to the danger of RF-induced heating near the lead tips. Phantom studies have shown that this heating varies significantly on a case-by-case basis, indicating that many patients with implanted devices can receive clinically useful MRI scans without harm. However, the difficulty of predicting RF-induced lead tip heating prior to scanning prevents numerous implant recipients from being scanned. Here, we demonstrate that thermo-acoustic ultrasound (TAUS) has the potential to be utilized for a pre-scan procedure assessing the risk of RF-induced lead tip heating in MRI. A system was developed to detect TAUS signals by four different TAUS acquisition methods. We then integrated this system with an MRI scanner and detected a peak in RF power absorption near the tip of a model lead when transmitting from the scanner's body coil. We also developed and experimentally validated simulations to characterize the thermo-acoustic signal generated near lead tips. These results indicate that TAUS is a promising method for assessing RF implant safety, and with further development, a TAUS pre-scan could allow many more patients to have access to MRI scans of significant clinical value.
Micropower RF transponder with superregenerative receiver and RF receiver with sampling mixer
McEwan, T.E.
1997-05-13
A micropower RF transponder employs a novel adaptation of the superregenerative receiver wherein the quench oscillator is external to the regenerative transistor. The quench oscillator applies an exponentially decaying waveform rather than the usual sinewave to achieve high sensitivity at microampere current levels. Further improvements include circuit simplifications for antenna coupling, extraction of the detected signal, and a low-voltage bias configuration that allows operation with less than a 1-volt rail voltage. The inventive transponder is expected to operate as long as the battery shelf life. 13 figs.
Bedse, Gaurav; Hartley, Nolan D; Neale, Emily; Gaulden, Andrew D; Patrick, Toni A; Kingsley, Philip J; Uddin, Md Jashim; Plath, Niels; Marnett, Lawrence J; Patel, Sachin
2017-10-01
Increasing the available repertoire of effective treatments for mood and anxiety disorders represents a critical unmet need. Pharmacological augmentation of endogenous cannabinoid (eCB) signaling has been suggested to represent a novel approach to the treatment of anxiety disorders; however, the functional interactions between two canonical eCB pathways mediated via anandamide (N-arachidonylethanolamine [AEA]) and 2-arachidonoylglycerol (2-AG) in the regulation of anxiety are not well understood. We utilized pharmacological augmentation and depletion combined with behavioral and electrophysiological approaches to probe the role of 2-AG signaling in the modulation of stress-induced anxiety and the functional redundancy between AEA and 2-AG signaling in the modulation of anxiety-like behaviors in mice. Selective 2-AG augmentation reduced anxiety in the light/dark box assay and prevented stress-induced increases in anxiety associated with limbic AEA deficiency. In contrast, acute 2-AG depletion increased anxiety-like behaviors, which was normalized by selective pharmacological augmentation of AEA signaling and via direct cannabinoid receptor 1 stimulation with Δ 9 -tetrahydrocannabinol. Electrophysiological studies revealed 2-AG modulation of amygdala glutamatergic transmission as a key synaptic correlate of the anxiolytic effects of 2-AG augmentation. Although AEA and 2-AG likely subserve distinct physiological roles, a pharmacological and functional redundancy between these canonical eCB signaling pathways exists in the modulation of anxiety-like behaviors. These data support development of eCB-based treatment approaches for mood and anxiety disorders and suggest a potentially wider therapeutic overlap between AEA and 2-AG augmentation approaches than was previously appreciated. Copyright © 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Integrated RF-shim coil allowing two degrees of freedom shim current.
Jiazheng Zhou; Ying-Hua Chu; Yi-Cheng Hsu; Pu-Yeh Wu; Stockmann, Jason P; Fa-Hsuan Lin
2016-08-01
High-quality magnetic resonance imaging and spectroscopic measurements require a highly homogeneous magnetic field. Different from global shimming, localized off-resonance can be corrected by using multi-coil shimming. Previously, integrated RF and shimming coils have been used to implement multi-coil shimming. Such coils share the same conductor for RF signal reception and shim field generation. Here we propose a new design of the integrated RF-shim coil at 3-tesla, where two independent shim current paths are allowed in each coil. This coil permits a higher degree of freedom in shim current distribution design. We use both phantom experiments and simulations to demonstrate the feasibility of this new design.
PEEL-AND-STICK SENSORS POWERED BY DIRECTED RF ENERGY
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lalau-Keraly, Chrisopher; Daniel, George; Lee, Joseph
PARC, a Xerox Company, is developing a low-cost system of peel-and-stick wireless sensors that will enable widespread building environment sensor deployment with the potential to deliver up to 30% energy savings. The system is embodied by a set of RF hubs that provide power to automatically located sensor nodes, and relay data wirelessly to the building management system (BMS). The sensor nodes are flexible electronic labels powered by rectified RF energy transmitted by an RF hub and can contain multiple printed and conventional sensors. The system design overcomes limitations in wireless sensors related to power delivery, lifetime, and cost bymore » eliminating batteries and photovoltaic devices. Sensor localization is performed automatically by the inclusion of a programmable multidirectional antenna array in the RF hub. Comparison of signal strengths while the RF beam is swept allows for sensor localization, reducing installation effort and enabling automatic recommissioning of sensors that have been relocated, overcoming a significant challenge in building operations. PARC has already demonstrated wireless power and temperature data transmission up to a distance of 20m with less than one minute between measurements, using power levels well within the FCC regulation limits in the 902-928 MHz ISM band. The sensor’s RF energy harvesting antenna achieves high performance with dimensions below 5cm x 9cm.« less
Peel-and-Stick Sensors Powered by Directed RF Energy
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lalau-Keraly, Christopher; Daniel, George; Lee, Joseph
PARC, a Xerox Company, is developing a low-cost system of peel-and-stick wireless sensors that will enable widespread building environment sensor deployment with the potential to deliver up to 30% energy savings. The system is embodied by a set of RF hubs that provide power to automatically located sensor nodes, and relay data wirelessly to the building management system (BMS). The sensor nodes are flexible electronic labels powered by rectified RF energy transmitted by an RF hub and can contain multiple printed and conventional sensors. The system design overcomes limitations in wireless sensors related to power delivery, lifetime, and cost bymore » eliminating batteries and photovoltaic devices. Sensor localization is performed automatically by the inclusion of a programmable multidirectional antenna array in the RF hub. Comparison of signal strengths while the RF beam is swept allows for sensor localization, reducing installation effort and enabling automatic recommissioning of sensors that have been relocated, overcoming a significant challenge in building operations. PARC has already demonstrated wireless power and temperature data transmission up to a distance of 20m with less than one minute between measurements, using power levels well within the FCC regulation limits in the 902-928 MHz ISM band. The sensor’s RF energy harvesting antenna achieves high performance with dimensions below 5cm x 9cm« less
Small-signal modulation characteristics of a polariton laser
Zunaid Baten, Md; Frost, Thomas; Iorsh, Ivan; Deshpande, Saniya; Kavokin, Alexey; Bhattacharya, Pallab
2015-01-01
Use of large bandgap materials together with electrical injection makes the polariton laser an attractive low-power coherent light source for medical and biomedical applications or short distance plastic fiber communication at short wavelengths (violet and ultra-violet), where a conventional laser is difficult to realize. The dynamic properties of a polariton laser have not been investigated experimentally. We have measured, for the first time, the small signal modulation characteristics of a GaN-based electrically pumped polariton laser operating at room temperature. A maximum −3 dB modulation bandwidth of 1.18 GHz is measured. The experimental results have been analyzed with a theoretical model based on the Boltzmann kinetic equations and the agreement is very good. We have also investigated frequency chirping during such modulation. Gain compression phenomenon in a polariton laser is interpreted and a value is obtained for the gain compression factor. PMID:26154681
Displacement Vector Measurement Using 2D Modulation by Virtual Hyperbolic Beam Forming
NASA Astrophysics Data System (ADS)
Kondo, Kengo; Yamakawa, Makoto; Shiina, Tsuyoshi
For the purpose of diagnosing ischemic heart disease by detection of malfunction area and cancer tumor by detection of hard area, 3-D tissue motion must be correctly evaluated. So far various methods of measuring multidimensional displacement have been developed. Most of present techniques are restricted to one-dimensional measurement of tissue displacement such as myocardial stain-rate imaging. Although lateral modulation method enables us to attain high-accuracy measurement of lateral displacement as well as axial direction by generating lateral oscillating RF signals, the method causes distorted RF far from center of aperture. As a result, the method is not suited to sector scan which is used for myocardial examination. We propose a method to solve the problem by using 2-D modulation with the virtual hyperbolic beam forming and detection of 2-D displacement vector. The feasibilities of the proposed method were evaluated by numerically simulating the left ventricle short-axis imaging of cylindrical myocardial model. The volume strain image obtained by the proposed method clearly depicted the hard infarction area where conventional multi-beam Doppler imaging could not.
2014-02-26
through RF filtering . Subsequently, this modulated signal is used in a cutback experiment with a passive fiber . Studies describing enhancement factors...to filter out higher order modes [3]. However, in order to maintain single-mode (diffraction limited) operation, conventional step-index fiber core...Letters 36, 2686-2688 (2011). [3] J. P. Koplaw, D. Kliner, and L. Goldberg, “Single-mode operation of a coiled multimode fiber amplifier,” Optics Letters
miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila.
Xiong, Xiao-Peng; Kurthkoti, Krishna; Chang, Kung-Yen; Li, Jian-Liang; Ren, Xingjie; Ni, Jian-Quan; Rana, Tariq M; Zhou, Rui
2016-11-01
microRNAs are endogenous small regulatory RNAs that modulate myriad biological processes by repressing target gene expression in a sequence-specific manner. Here we show that the conserved miRNA miR-34 regulates innate immunity and ecdysone signaling in Drosophila. miR-34 over-expression activates antibacterial innate immunity signaling both in cultured cells and in vivo, and flies over-expressing miR-34 display improved survival and pathogen clearance upon Gram-negative bacterial infection; whereas miR-34 knockout animals are defective in antibacterial defense. In particular, miR-34 achieves its immune-stimulatory function, at least in part, by repressing the two novel target genes Dlg1 and Eip75B. In addition, our study reveals a mutual repression between miR-34 expression and ecdysone signaling, and identifies miR-34 as a node in the intricate interplay between ecdysone signaling and innate immunity. Lastly, we identify cis-regulatory genomic elements and trans-acting transcription factors required for optimal ecdysone-mediated repression of miR-34. Taken together, our study enriches the repertoire of immune-modulating miRNAs in animals, and provides new insights into the interplay between steroid hormone signaling and innate immunity.
Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences.
Donzis, Elissa J; Tronson, Natalie C
2014-11-01
This review describes the role of cytokines and their downstream signaling cascades on the modulation of learning and memory. Immune proteins are required for many key neural processes and dysregulation of these functions by systemic inflammation can result in impairments of memory that persist long after the resolution of inflammation. Recent research has demonstrated that manipulations of individual cytokines can modulate learning, memory, and synaptic plasticity. The many conflicting findings, however, have prevented a clear understanding of the precise role of cytokines in memory. Given the complexity of inflammatory signaling, understanding its modulatory role requires a shift in focus from single cytokines to a network of cytokine interactions and elucidation of the cytokine-dependent intracellular signaling cascades. Finally, we propose that whereas signal transduction and transcription may mediate short-term modulation of memory, long-lasting cellular and molecular mechanisms such as epigenetic modifications and altered neurogenesis may be required for the long lasting impact of inflammation on memory and cognition. Copyright © 2014 Elsevier Inc. All rights reserved.
Zhou, Wen; Li, Xinying; Yu, Jianjun
2017-10-30
We propose QPSK millimeter-wave (mm-wave) vector signal generation for D-band based on balanced precoding-assisted photonic frequency quadrupling technology employing a single intensity modulator without an optical filter. The intensity MZM is driven by a balanced pre-coding 37-GHz QPSK RF signal. The modulated optical subcarriers are directly sent into the single ended photodiode to generate 148-GHz QPSK vector signal. We experimentally demonstrate 1-Gbaud 148-GHz QPSK mm-wave vector signal generation, and investigate the bit-error-rate (BER) performance of the vector signals at 148-GHz. The experimental results show that the BER value can be achieved as low as 1.448 × 10 -3 when the optical power into photodiode is 8.8dBm. To the best of our knowledge, it is the first time to realize the frequency-quadrupling vector mm-wave signal generation at D-band based on only one MZM without an optical filter.
Design and implementation of quadrature bandpass sigma-delta modulator used in low-IF RF receiver
NASA Astrophysics Data System (ADS)
Ge, Binjie; Li, Yan; Yu, Hang; Feng, Xiaoxing
2018-05-01
This paper presents the design and implementation of quadrature bandpass sigma-delta modulator. A pole movement method for transforming real sigma-delta modulator to a quadrature one is proposed by detailed study of the relationship of noise-shaping center frequency and integrator pole position in sigma-delta modulator. The proposed modulator uses sampling capacitor sharing switched capacitor integrator, and achieves a very small feedback coefficient by a series capacitor network, and those two techniques can dramatically reduce capacitor area. Quantizer output-dependent dummy capacitor load for reference voltage buffer can compensate signal-dependent noise that is caused by load variation. This paper designs a quadrature bandpass Sigma-Delta modulator for 2.4 GHz low IF receivers that achieve 69 dB SNDR at 1 MHz BW and -1 MHz IF with 48 MHz clock. The chip is fabricated with SMIC 0.18 μm CMOS technology, it achieves a total power current of 2.1 mA, and the chip area is 0.48 mm2. Project supported by the National Natural Science Foundation of China (Nos. 61471245, U1201256), the Guangdong Province Foundation (No. 2014B090901031), and the Shenzhen Foundation (Nos. JCYJ20160308095019383, JSGG20150529160945187).
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 3 2010-01-01 2010-01-01 false Uniform test method for the measurement of energy consumption for traffic signal modules and pedestrian modules. 431.224 Section 431.224 Energy DEPARTMENT OF... measurement of energy consumption for traffic signal modules and pedestrian modules. (a) Scope. This section...
NASA Astrophysics Data System (ADS)
Morgan, I.; Benjamin, J. D.
1985-08-01
Methods of powering devices to which only ac contact can be made and receiving data transmitted back from them are described. Such devices include medical implants which communicate with the external environment via ultrasound or rf links. Two breadboard systems were built to demonstrate the techniques. In both the device is powered by picking up an ac input and rectifying it. A signal voltage detected by the device is encoded as a frequency, transmitted and decoded. In one case this is performed on a separate channel from that used to power the device. In the other only one channel is used for both signals, and data is transmitted by modulating the impedance presented by the device. The resulting modulation of the input signal is picked up by the external circuit and decoded.
NASA Astrophysics Data System (ADS)
Tezuka, Miwa; Kanno, Kazutaka; Bunsen, Masatoshi
2016-08-01
Reservoir computing is a machine-learning paradigm based on information processing in the human brain. We numerically demonstrate reservoir computing with a slowly modulated mask signal for preprocessing by using a mutually coupled optoelectronic system. The performance of our system is quantitatively evaluated by a chaotic time series prediction task. Our system can produce comparable performance with reservoir computing with a single feedback system and a fast modulated mask signal. We showed that it is possible to slow down the modulation speed of the mask signal by using the mutually coupled system in reservoir computing.
Monitoring Spacecraft Telemetry Via Optical or RF Link
NASA Technical Reports Server (NTRS)
Fielhauer, K. B.; Boone, B. G.
2011-01-01
A patent disclosure document discusses a photonic method for connecting a spacecraft with a launch vehicle upper-stage telemetry system as a means for monitoring a spacecraft fs health and status during and right after separation and deployment. This method also provides an efficient opto-coupled capability for prelaunch built-in-test (BIT) on the ground to enable more efficient and timely integration, preflight checkout, and a means to obviate any local EMI (electromagnetic interference) during integration and test. Additional utility can be envisioned for BIT on other platforms, such as the International Space Station (ISS). The photonic telemetry system implements an optical free-space link with a divergent laser transmitter beam spoiled over a significant cone angle to accommodate changes in spacecraft position without having to angle track it during deployment. Since the spacecraft may lose attitude control and tumble during deployment, the transmitted laser beam interrogates any one of several low-profile meso-scale retro-reflective spatial light modulators (SLMs) deployed over the surface of the spacecraft. The return signal beam, modulated by the SLMs, contains health, status, and attitude information received back at the launch vehicle. Very compact low-power opto-coupler technology already exists for the received signal (requiring relatively low bandwidths, e.g., .200 kbps) to enable transfer to a forward pass RF relay from the launch vehicle to TDRSS (Tracking and Data Relay Satellite System) or another recipient. The link would be active during separation and post-separation to monitor spacecraft health, status, attitude, or other data inventories until attitude recovery and ground control can be re-established. An optical link would not interfere with the existing upper stage telemetry and beacon systems, thus meeting launch vehicle EMI environmental constraints.
Dowla, Farid U; Nekoogar, Faranak
2015-03-03
A method for adaptive Radio Frequency (RF) jamming according to one embodiment includes dynamically monitoring a RF spectrum; detecting any undesired signals in real time from the RF spectrum; and sending a directional countermeasure signal to jam the undesired signals. A method for adaptive Radio Frequency (RF) communications according to another embodiment includes transmitting a data pulse in a RF spectrum; and transmitting a reference pulse separated by a predetermined period of time from the data pulse; wherein the data pulse is modulated with data, wherein the reference pulse is unmodulated. A method for adaptive Radio Frequency (RF) communications according to yet another embodiment includes receiving a data pulse in a RF spectrum; and receiving a reference pulse separated in time from the data pulse, wherein the data pulse is modulated with data, wherein the reference pulse is unmodulated; and demodulating the pulses.
Modulation of V1 Spike Response by Temporal Interval of Spatiotemporal Stimulus Sequence
Kim, Taekjun; Kim, HyungGoo R.; Kim, Kayeon; Lee, Choongkil
2012-01-01
The spike activity of single neurons of the primary visual cortex (V1) becomes more selective and reliable in response to wide-field natural scenes compared to smaller stimuli confined to the classical receptive field (RF). However, it is largely unknown what aspects of natural scenes increase the selectivity of V1 neurons. One hypothesis is that modulation by surround interaction is highly sensitive to small changes in spatiotemporal aspects of RF surround. Such a fine-tuned modulation would enable single neurons to hold information about spatiotemporal sequences of oriented stimuli, which extends the role of V1 neurons as a simple spatiotemporal filter confined to the RF. In the current study, we examined the hypothesis in the V1 of awake behaving monkeys, by testing whether the spike response of single V1 neurons is modulated by temporal interval of spatiotemporal stimulus sequence encompassing inside and outside the RF. We used two identical Gabor stimuli that were sequentially presented with a variable stimulus onset asynchrony (SOA): the preceding one (S1) outside the RF and the following one (S2) in the RF. This stimulus configuration enabled us to examine the spatiotemporal selectivity of response modulation from a focal surround region. Although S1 alone did not evoke spike responses, visual response to S2 was modulated for SOA in the range of tens of milliseconds. These results suggest that V1 neurons participate in processing spatiotemporal sequences of oriented stimuli extending outside the RF. PMID:23091631
Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling*
Moreno, Estefanía; Andradas, Clara; Medrano, Mireia; Caffarel, María M.; Pérez-Gómez, Eduardo; Blasco-Benito, Sandra; Gómez-Cañas, María; Pazos, M. Ruth; Irving, Andrew J.; Lluís, Carme; Canela, Enric I.; Fernández-Ruiz, Javier; Guzmán, Manuel; McCormick, Peter J.; Sánchez, Cristina
2014-01-01
The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology. PMID:24942731
PACAP/PAC1R signaling modulates acetylcholine release at neuronal nicotinic synapses
Pugh, Phyllis C.; Jayakar, Selwyn S.; Margiotta, Joseph F.
2009-01-01
Neuropeptides collaborate with conventional neurotransmitters to regulate synaptic output. Pituitary adenylate cyclase-activating polypeptide (PACAP) co-localizes with acetylcholine in presynaptic nerve terminals, is released by stimulation, and enhances nicotinic acetylcholine receptor- (nAChR-) mediated responses. Such findings implicate PACAP in modulating nicotinic neurotransmission, but relevant synaptic mechanisms have not been explored. We show here that PACAP acts via selective high-affinity G-protein coupled receptors (PAC1Rs) to enhance transmission at nicotinic synapses on parasympathetic ciliary ganglion (CG) neurons by rapidly and persistently increasing the frequency and amplitude of spontaneous, impulse-dependent nicotinic excitatory postsynaptic currents (sEPSCs). Of the canonical adenylate cyclase (AC) and phospholipase-C (PLC) transduction cascades stimulated by PACAP/PAC1R signaling, only AC-generated signals are critical for synaptic modulation since the increases in sEPSC frequency and amplitude were mimicked by 8-Bromo-cAMP, blocked by inhibiting AC or cAMP-dependent protein kinase (PKA), and unaffected by inhibiting PLC. Despite its ability to increase agonist-induced nAChR currents, PACAP failed to influence nAChR-mediated impulse-independent miniature EPSC amplitudes (quantal size). Instead, evoked transmission assays reveal that PACAP/PAC1R signaling increased quantal content, indicating it modulates synaptic function by increasing vesicular ACh release from presynaptic terminals. Lastly, signals generated by the retrograde messenger, nitric oxide- (NO-) are critical for the synaptic modulation since the PACAP-induced increases in spontaneous EPSC frequency, amplitude and quantal content were mimicked by NO donor and absent after inhibiting NO synthase (NOS). These results indicate that PACAP/PAC1R activation recruits AC-dependent signaling that stimulates NOS to increase NO production and control presynaptic transmitter output at neuronal
Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts
Baker, Wesley B.; Parthasarathy, Ashwin B.; Ko, Tiffany S.; Busch, David R.; Abramson, Kenneth; Tzeng, Shih-Yu; Mesquita, Rickson C.; Durduran, Turgut; Greenberg, Joel H.; Kung, David K.; Yodh, Arjun G.
2015-01-01
Abstract. We introduce and validate a pressure measurement paradigm that reduces extracerebral contamination from superficial tissues in optical monitoring of cerebral blood flow with diffuse correlation spectroscopy (DCS). The scheme determines subject-specific contributions of extracerebral and cerebral tissues to the DCS signal by utilizing probe pressure modulation to induce variations in extracerebral blood flow. For analysis, the head is modeled as a two-layer medium and is probed with long and short source-detector separations. Then a combination of pressure modulation and a modified Beer-Lambert law for flow enables experimenters to linearly relate differential DCS signals to cerebral and extracerebral blood flow variation without a priori anatomical information. We demonstrate the algorithm’s ability to isolate cerebral blood flow during a finger-tapping task and during graded scalp ischemia in healthy adults. Finally, we adapt the pressure modulation algorithm to ameliorate extracerebral contamination in monitoring of cerebral blood oxygenation and blood volume by near-infrared spectroscopy. PMID:26301255
Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts.
Baker, Wesley B; Parthasarathy, Ashwin B; Ko, Tiffany S; Busch, David R; Abramson, Kenneth; Tzeng, Shih-Yu; Mesquita, Rickson C; Durduran, Turgut; Greenberg, Joel H; Kung, David K; Yodh, Arjun G
2015-07-01
We introduce and validate a pressure measurement paradigm that reduces extracerebral contamination from superficial tissues in optical monitoring of cerebral blood flow with diffuse correlation spectroscopy (DCS). The scheme determines subject-specific contributions of extracerebral and cerebral tissues to the DCS signal by utilizing probe pressure modulation to induce variations in extracerebral blood flow. For analysis, the head is modeled as a two-layer medium and is probed with long and short source-detector separations. Then a combination of pressure modulation and a modified Beer-Lambert law for flow enables experimenters to linearly relate differential DCS signals to cerebral and extracerebral blood flow variation without a priori anatomical information. We demonstrate the algorithm's ability to isolate cerebral blood flow during a finger-tapping task and during graded scalp ischemia in healthy adults. Finally, we adapt the pressure modulation algorithm to ameliorate extracerebral contamination in monitoring of cerebral blood oxygenation and blood volume by near-infrared spectroscopy.
A Signal Processing Module for the Analysis of Heart Sounds and Heart Murmurs
NASA Astrophysics Data System (ADS)
Javed, Faizan; Venkatachalam, P. A.; H, Ahmad Fadzil M.
2006-04-01
In this paper a Signal Processing Module (SPM) for the computer-aided analysis of heart sounds has been developed. The module reveals important information of cardiovascular disorders and can assist general physician to come up with more accurate and reliable diagnosis at early stages. It can overcome the deficiency of expert doctors in rural as well as urban clinics and hospitals. The module has five main blocks: Data Acquisition & Pre-processing, Segmentation, Feature Extraction, Murmur Detection and Murmur Classification. The heart sounds are first acquired using an electronic stethoscope which has the capability of transferring these signals to the near by workstation using wireless media. Then the signals are segmented into individual cycles as well as individual components using the spectral analysis of heart without using any reference signal like ECG. Then the features are extracted from the individual components using Spectrogram and are used as an input to a MLP (Multiple Layer Perceptron) Neural Network that is trained to detect the presence of heart murmurs. Once the murmur is detected they are classified into seven classes depending on their timing within the cardiac cycle using Smoothed Pseudo Wigner-Ville distribution. The module has been tested with real heart sounds from 40 patients and has proved to be quite efficient and robust while dealing with a large variety of pathological conditions.
Valberg, Peter A; van Deventer, T Emilie; Repacholi, Michael H
2007-03-01
Radiofrequency (RF) waves have long been used for different types of information exchange via the air waves--wireless Morse code, radio, television, and wireless telephone (i.e., construction and operation of telephones or telephone systems). Increasingly larger numbers of people rely on mobile telephone technology, and health concerns about the associated RF exposure have been raised, particularly because the mobile phone handset operates in close proximity to the human body, and also because large numbers of base station antennas are required to provide widespread availability of service to large populations. The World Health Organization convened an expert workshop to discuss the current state of cellular-telephone health issues, and this article brings together several of the key points that were addressed. The possibility of RF health effects has been investigated in epidemiology studies of cellular telephone users and workers in RF occupations, in experiments with animals exposed to cell-phone RF, and via biophysical consideration of cell-phone RF electric-field intensity and the effect of RF modulation schemes. As summarized here, these separate avenues of scientific investigation provide little support for adverse health effects arising from RF exposure at levels below current international standards. Moreover, radio and television broadcast waves have exposed populations to RF for > 50 years with little evidence of deleterious health consequences. Despite unavoidable uncertainty, current scientific data are consistent with the conclusion that public exposures to permissible RF levels from mobile telephone and base stations are not likely to adversely affect human health.
Valberg, Peter A.; van Deventer, T. Emilie; Repacholi, Michael H.
2007-01-01
Radiofrequency (RF) waves have long been used for different types of information exchange via the airwaves—wireless Morse code, radio, television, and wireless telephony (i.e., construction and operation of telephones or telephonic systems). Increasingly larger numbers of people rely on mobile telephone technology, and health concerns about the associated RF exposure have been raised, particularly because the mobile phone handset operates in close proximity to the human body, and also because large numbers of base station antennas are required to provide widespread availability of service to large populations. The World Health Organization convened an expert workshop to discuss the current state of cellular-telephone health issues, and this article brings together several of the key points that were addressed. The possibility of RF health effects has been investigated in epidemiology studies of cellular telephone users and workers in RF occupations, in experiments with animals exposed to cell-phone RF, and via biophysical consideration of cell-phone RF electric-field intensity and the effect of RF modulation schemes. As summarized here, these separate avenues of scientific investigation provide little support for adverse health effects arising from RF exposure at levels below current international standards. Moreover, radio and television broadcast waves have exposed populations to RF for > 50 years with little evidence of deleterious health consequences. Despite unavoidable uncertainty, current scientific data are consistent with the conclusion that public exposures to permissible RF levels from mobile telephony and base stations are not likely to adversely affect human health. PMID:17431492
Hou, Shulian; Xie, Huantong; Chen, Wei; Wang, Guangxin; Zhao, Qiang; Li, Shiyu
2014-10-01
In the development of radio frequency (RF) coils for better quality of the mini-type permanent magnetic resonance imager for using in the small animal imaging, the solenoid RF coil has a special advantage for permanent magnetic system based on analyses of various types.of RF coils. However, it is not satisfied for imaging if the RF coils are directly used. By theoretical analyses of the magnetic field properties produced from the solenoid coil, the research direction was determined by careful studies to raise further the uniformity of the magnetic field coil, receiving coil sensitivity for signals and signal-to-noise ratio (SNR). The method had certain advantages and avoided some shortcomings of the other different coil types, such as, birdcage coil, saddle shaped coil and phased array coil by using the alloy materials (from our own patent). The RF coils were designed, developed and made for keeled applicable to permanent magnet-type magnetic resonance imager, multi-coil combination-type, single-channel overall RF receiving coil, and applied for a patent. Mounted on three instruments (25 mm aperture, with main magnetic field strength of 0.5 T or 1.5 T, and 50 mm aperture, with main magnetic field strength of 0.48 T), we performed experiments with mice, rats, and nude mice bearing tumors. The experimental results indicated that the RF receiving coil was fully applicable to the permanent magnet-type imaging system.
Digital processing of signals from femtosecond combs
NASA Astrophysics Data System (ADS)
Čížek, Martin; Šmíd, Radek; Buchta, Zdeněk.; Mikel, Břetislav; Lazar, Josef; Číp, Ondrej
2012-01-01
The presented work is focused on digital processing of beat note signals from a femtosecond optical frequency comb. The levels of mixing products of single spectral components of the comb with CW laser sources are usually very low compared to products of mixing all the comb components together. RF counters are more likely to measure the frequency of the strongest spectral component rather than a weak beat note. Proposed experimental digital signal processing system solves this problem by analyzing the whole spectrum of the output RF signal and using software defined radio (SDR) algorithms. Our efforts concentrate in two main areas: Firstly, we are experimenting with digital signal processing of the RF beat note spectrum produced by f-2f 1 technique and with fully digital servo-loop stabilization of the fs comb. Secondly, we are using digital servo-loop techniques for locking free running continuous laser sources on single components of the fs comb spectrum. Software capable of computing and analyzing the beat-note RF spectrums using FFT and peak detection was developed. A SDR algorithm performing phase demodulation on the f- 2f signal is used as a regulation error signal source for a digital phase-locked loop stabilizing the offset and repetition frequencies of the fs comb.
miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila
Xiong, Xiao-Peng; Chang, Kung-Yen; Ren, Xingjie; Ni, Jian-Quan; Rana, Tariq M.; Zhou, Rui
2016-01-01
microRNAs are endogenous small regulatory RNAs that modulate myriad biological processes by repressing target gene expression in a sequence-specific manner. Here we show that the conserved miRNA miR-34 regulates innate immunity and ecdysone signaling in Drosophila. miR-34 over-expression activates antibacterial innate immunity signaling both in cultured cells and in vivo, and flies over-expressing miR-34 display improved survival and pathogen clearance upon Gram-negative bacterial infection; whereas miR-34 knockout animals are defective in antibacterial defense. In particular, miR-34 achieves its immune-stimulatory function, at least in part, by repressing the two novel target genes Dlg1 and Eip75B. In addition, our study reveals a mutual repression between miR-34 expression and ecdysone signaling, and identifies miR-34 as a node in the intricate interplay between ecdysone signaling and innate immunity. Lastly, we identify cis-regulatory genomic elements and trans-acting transcription factors required for optimal ecdysone-mediated repression of miR-34. Taken together, our study enriches the repertoire of immune-modulating miRNAs in animals, and provides new insights into the interplay between steroid hormone signaling and innate immunity. PMID:27893816
Astrophysics-independent bounds on the annual modulation of dark matter signals.
Herrero-Garcia, Juan; Schwetz, Thomas; Zupan, Jure
2012-10-05
We show how constraints on the time integrated event rate from a given dark matter (DM) direct detection experiment can be used to bound the amplitude of the annual modulation signal in another experiment. The method requires only mild assumptions about the properties of the local DM distribution: that it is temporally stable on the scale of months and spatially homogeneous on the ecliptic. We apply the method to the annual modulation signal in DAMA/LIBRA, which we compare to the bounds derived from XENON10, XENON100, cryogenic DM search, and SIMPLE data. Assuming a DM mass of 10 GeV, we show that under the above assumptions about the DM halo, a DM interpretation of the DAMA/LIBRA signal is excluded for several classes of models: at 6.3σ (4.6σ) for elastic isospin conserving (violating) spin-independent interactions, and at 4.9σ for elastic spin-dependent interactions on protons.
Modeling of RF/MHD coupling using NIMROD, GENRAY, and the Integrated Plasma Simulator
NASA Astrophysics Data System (ADS)
Jenkins, Thomas; Schnack, D. D.; Sovinec, C. R.; Hegna, C. C.; Callen, J. D.; Ebrahimi, F.; Kruger, S. E.; Carlsson, J.; Held, E. D.; Ji, J.-Y.; Harvey, R. W.; Smirnov, A. P.
2009-05-01
We summarize ongoing theoretical/numerical work relevant to the development of a self--consistent framework for the inclusion of RF effects in fluid simulations; specifically considering resistive tearing mode stabilization in tokamak (DIII--D--like) geometry via ECCD. Relatively simple (though non--self--consistent) models for the RF--induced currents are incorporated into the fluid equations, markedly reducing the width of the nonlinearly saturated magnetic islands generated by tearing modes. We report our progress toward the self--consistent modeling of these RF--induced currents. The initial interfacing of the NIMROD* code with the GENRAY/CQL3D** codes (calculating RF propagation and energy/momentum deposition) via the Integrated Plasma Simulator (IPS) framework*** is explained, equilibration of RF--induced currents over the plasma flux surfaces is investigated, and studies exploring the efficient reduction of saturated island widths through time modulation and spatial localization of the ECCD are presented. *[Sovinec et al., JCP 195, 355 (2004)] **[www.compxco.com] ***[This research and the IPS development are both part of the SWIM project. Funded by U.S. DoE.
Synthesis of ultrafine Si3N4 powder in RF-RF plasma
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sato, Michitaka; Nishio, Hiroaki
1991-10-01
A newly designed plasma-CVD apparatus mounted with the RF-RF type plasma torch was introduced to synthesize ultrafine powders of silicon nitride (Si3N4). The RF-RF plasma system (the combination of a main (lower) and controlling (upper) RF plasma) improved the stability of simple RF plasma and solved the impurity problem of dc-RF hybrid plasma. The reaction of SiCl4 and NH3, which were radially injected into the tail flames of the upper and lower plasmas, respectively, yielded near-stoichiometric amorphous powders of Si3N4. The nitrogen content in the products largely depended on the flow rate of the quenching gas, a mixture of NH3more » (reactant) and H2. The oxygen content and metal impurities are 2-3 wt pct and less than 200 ppm, respectively. The powder particles had an average diameter of about 15 nm with a narrow size distribution, and showed extreme air sensitivity. Conspicuous crystallazation and particle growth occurred when heated at temperatures above 1400 C. These results suggested that the RF-RF system was a potential reactor for the synthesis of ultrafine powders with excellent sinterability at relatively low temperatures. 9 refs.« less
Kozloski, Goldi A; Carraway, Coralie A Carothers; Carraway, Kermit L
2010-09-01
The membrane mucin Muc4 is aberrantly expressed in numerous epithelial carcinomas and is currently used as a cancer diagnostic and prognostic tool. Muc4 can also potentiate signal transduction by modulating differential ErbB2 phosphorylation in the absence and in the presence of the ErbB3 soluble ligand heregulin (HRG-beta1). These features of Muc4 suggest that Muc4 is not merely a cancer marker, but an oncogenic factor with a unique-binding/activation relationship with the receptor ErbB2. In the present study, we examined the signaling mechanisms that are associated with the Muc4-ErbB2 module by analyzing ErbB2 differential signaling in response to Muc4 expression. Our study was carried out in the A375 human melanoma and BT-474 breast cancer cell lines as our model systems. Quantitative and comparative signaling modulations were evaluated by immunoblot using phospho-specific antibodies, and densitometry analysis. Signaling complex components were identified by chemical cross-linking, fractionation by gel filtration, immunoprecipitation, and immunoblotting. Activated downstream signaling pathways were analyzed by an antibody microarray screen and immunoblot analyses. Our results indicate that Muc4 modulates ErbB2 signaling potential significantly by stabilizing and directly interacting with the ErbB2-ErbB3 heterodimer. Further analyses indicate that Muc4 promotes ErbB2 autocatalysis, but it has no effect on ErbB3 phosphorylation, although the chemical cross-linking data indicated that the signaling module is composed of Muc4, ErbB2, and ErbB3. Our microarray analysis indicates that Muc4 expression promotes cell migration by increasing the phosphorylation of the focal adhesion kinase and also through an increase in the levels of beta-catenin. (c) 2010 Wiley-Liss, Inc.
Rf Feedback free electron laser
Brau, Charles A.; Swenson, Donald A.; Boyd, Jr., Thomas J.
1981-01-01
A free electron laser system and electron beam system for a free electron laser which use rf feedback to enhance efficiency. Rf energy is extracted from an electron beam by decelerating cavities and returned to accelerating cavities using rf returns such as rf waveguides, rf feedthroughs, etc. This rf energy is added to rf klystron energy to lower the required input energy and thereby enhance energy efficiency of the system.
Modulation of taste sensitivity by GLP-1 signaling in taste buds.
Martin, Bronwen; Dotson, Cedrick D; Shin, Yu-Kyong; Ji, Sunggoan; Drucker, Daniel J; Maudsley, Stuart; Munger, Steven D
2009-07-01
Modulation of sensory function can help animals adjust to a changing external and internal environment. Even so, mechanisms for modulating taste sensitivity are poorly understood. Using immunohistochemical, biochemical, and behavioral approaches, we found that the peptide hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) are expressed in mammalian taste buds. Furthermore, we found that GLP-1 signaling plays an important role in the modulation of taste sensitivity: GLP-1R knockout mice exhibit a dramatic reduction in sweet taste sensitivity as well as an enhanced sensitivity to umami-tasting stimuli. Together, these findings suggest a novel paracrine mechanism for the hormonal modulation of taste function in mammals.
NASA Astrophysics Data System (ADS)
Han, Xifeng; Zhou, Wen
2018-03-01
Optical vector radio-frequency (RF) signal generation based on optical carrier suppression (OCS) in one Mach-Zehnder modulator (MZM) can realize frequency-doubling. In order to match the phase or amplitude of the recovered quadrature amplitude modulation (QAM) signal, phase or amplitude pre-coding is necessary in the transmitter side. The detected QAM signals usually have one non-uniform phase distribution after square-law detection at the photodiode because of the imperfect characteristics of the optical and electrical devices. We propose to use optimal threshold of error decision for non-uniform phase contribution to reduce the bit error rate (BER). By employing this scheme, the BER of 16 Gbaud (32 Gbit/s) quadrature-phase-shift-keying (QPSK) millimeter wave signal at 36 GHz is improved from 1 × 10-3 to 1 × 10-4 at - 4 . 6 dBm input power into the photodiode.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Dowla, Farid; Nekoogar, Faranak
A method for adaptive Radio Frequency (RF) jamming according to one embodiment includes dynamically monitoring a RF spectrum; detecting any undesired signals in real time from the RF spectrum; and sending a directional countermeasure signal to jam the undesired signals. A method for adaptive Radio Frequency (RF) communications according to another embodiment includes transmitting a data pulse in a RF spectrum; and transmitting a reference pulse separated by a predetermined period of time from the data pulse; wherein the data pulse is modulated with data, wherein the reference pulse is unmodulated. A method for adaptive Radio Frequency (RF) communications accordingmore » to yet another embodiment includes receiving a data pulse in a RF spectrum; and receiving a reference pulse separated in time from the data pulse, wherein the data pulse is modulated with data, wherein the reference pulse is unmodulated; and demodulating the pulses.« less
Rf feedback free electron laser
Brau, C.A.; Swenson, D.A.; Boyd, T.J. Jr.
1979-11-02
A free electron laser system and electron beam system for a free electron laser are provided which use rf feedback to enhance efficiency. Rf energy is extracted from an electron beam by decelerating cavities and returned to accelerating cavities using rf returns such as rf waveguides, rf feedthroughs, etc. This rf energy is added to rf klystron energy to lower the required input energy and thereby enhance energy efficiency of the system.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Xiao, Renzhen; Song, Zhimin; Deng, Yuqun
Theoretical analyses and particle-in-cell (PIC) simulations are carried out to understand the mechanism of microwave phase control realized by the external RF signal in a klystron-like relativistic backward wave oscillator (RBWO). Theoretical calculations show that a modulated electron beam can lead the microwave field with an arbitrary initial phase to the same equilibrium phase, which is determined by the phase factor of the modulated current, and the difference between them is fixed. Furthermore, PIC simulations demonstrate that the phase of input signal has a close relation to that of modulated current, which initiates the phase of the irregularly microwave duringmore » the build-up of oscillation. Since the microwave field is weak during the early time of starting oscillation, it is easy to be induced, and a small input signal is sufficient to control the phase of output microwave. For the klystron-like RBWO with two pre-modulation cavities and a reentrant input cavity, an input signal with 100 kW power and 4.21 GHz frequency can control the phase of 5 GW output microwave with relative phase difference less than 6% when the diode voltage is 760 kV, and beam current is 9.8 kA, corresponding to a power ratio of output microwave to input signal of 47 dB.« less
Multi-Channel RF System for MRI-Guided Transurethral Ultrasound Thermal Therapy
NASA Astrophysics Data System (ADS)
Yak, Nicolas; Asselin, Matthew; Chopra, Rajiv; Bronskill, Michael
2009-04-01
MRI-guided transurethral ultrasound thermal therapy is an approach to treating localized prostate cancer which targets precise deposition of thermal energy within a confined region of the gland. This treatment requires a system incorporating a heating applicator with multiple planar ultrasound transducers and associated RF electronics to control individual elements independently in order to achieve accurate 3D treatment. We report the design, construction, and characterization of a prototype multi-channel system capable of controlling 16 independent RF signals for a 16-element heating applicator. The main components are a control computer, microcontroller, and a 16-channel signal generator with 16 amplifiers, each incorporating a low-pass filter and transmitted/reflected power detection circuit. Each channel can deliver from 0.5 to 10 W of electrical power and good linearity from 3 to 12 MHz. Harmonic RF signals near the Larmor frequency of a 1.5 T MRI were measured to be below -30 dBm and heating experiments within the 1.5 T MR system showed no significant decrease in SNR of the temperature images. The frequency and power for all 16 channels could be changed in less than 250 ms, which was sufficiently rapid for proper performance of the control algorithms. A common backplane design was chosen which enabled an inexpensive, modular approach for each channel resulting in an overall system with minimal footprint.
Effect of RF Gradient upon the Performance of the Wisconsin SRF Electron Gun
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bosch, Robert; Legg, Robert A.
2013-12-01
The performance of the Wisconsin 200-MHz SRF electron gun is simulated for several values of the RF gradient. Bunches with charge of 200 pC are modeled for the case where emittance compensation is completed during post-acceleration to 85 MeV in a TESLA module. We first perform simulations in which the initial bunch radius is optimal for the design gradient of 41 MV/m. We then optimize the radius as a function of RF gradient to improve the performance for low gradients.
NASA Astrophysics Data System (ADS)
Yang, Xiyan; Wu, Yahao; Yuan, Zhanjiang
2015-06-01
Two-component signaling modules exist extensively in bacteria and microbes. These modules can be, based on their distinct network structures, divided into two types: the monofunctional system (denoted by MFS) where the sensor kinase (SK) modulates only phosphorylation of the response regulator (RR), and the bifunctional system (denoted by BFS) where the SK catalyzes both phosphorylation and dephosphorylation of the RR. Here, we analyze dynamical behaviors of these two systems based on stability theory, focusing on differences between them. The analysis of the deterministic behavior indicates that there is no difference between the two modules, that is, each system has the unique stable steady state. However, there are significant differences in stochastic behavior between them. Specifically, if the mean phosphorylated SK level is kept the same for the two modules, then the variance and the Fano factor for the phosphorylated RR in the BFS are always no less than those in the MFS, indicating that bifunctionality always enhances fluctuations. The correlation between the phosphorylated SK and the phosphorylated RR in the BFS is always positive mainly due to competition between system components, but this correlation in the MFS may be positive, almost zero, or negative, depending on the ratio between two rate constants. Our overall analysis indicates that differences between dynamical behaviors of monofunctional and bifunctional signaling modules are mainly in the stochastic rather than deterministic aspect.
Development and performance test of a new high power RF window in S-band PLS-II LINAC
NASA Astrophysics Data System (ADS)
Hwang, Woon-Ha; Joo, Young-Do; Kim, Seung-Hwan; Choi, Jae-Young; Noh, Sung-Ju; Ryu, Ji-Wan; Cho, Young-Ki
2017-12-01
A prototype of RF window was developed in collaboration with the Pohang Accelerator Laboratory (PAL) and domestic companies. High power performance tests of the single RF window were conducted at PAL to verify the operational characteristics for its application in the Pohang Light Source-II (PLS-II) linear accelerator (Linac). The tests were performed in the in-situ facility consisting of a modulator, klystron, waveguide network, vacuum system, cooling system, and RF analyzing equipment. The test results with Stanford linear accelerator energy doubler (SLED) have shown no breakdown up to 75 MW peak power with 4.5 μs RF pulse width at a repetition rate of 10 Hz. The test results with the current operation level of PLS-II Linac confirm that the RF window well satisfies the criteria for PLS-II Linac operation.
Numerical Simulation of Liquid Metal RF MEMS Switch Based on EWOD
NASA Astrophysics Data System (ADS)
Liu, Tingting; Gao, Yang; Yang, Tao; Guo, Huihui
2018-03-01
Conventional RF MEMS switches rely on metal-to-dielectric or metal-to-metal contacts. Some problems in the “solid-solid” contact, such as contact degradation, signal bounce and poor reliability, can be solved by using “liquid-solid” contact. The RF MEMS switch based on liquid metal is characterized by small contact resistance, no moving parts, high reliability and long life. Using electrowetting-on-dielectric (EWOD) way to control the movement of liquid metal in the RF MEMS switch, to achieve the “on” and “off” of the switch. In this paper, the electrical characteristics and RF characteristics of RF MEMS switches are simulated by fluid mechanics software FLUENT and electromagnetic simulation software HFSS. The effects of driving voltage, switching time, dielectric layer, hydrophobic layer material and thickness, switching channel height on the RF characteristics are studied. The results show that to increase the external voltage to the threshold voltage of 58V, the liquid metal began to move, and the switching time from “off” state to “on” state is 16ms. In the 0~20GHz frequency range, the switch insertion loss is less than 0.28dB, isolation is better than 23.32dB.
High-Power X-Band Semiconductor RF Switch for Pulse Compression Systems of Future Colliders
NASA Astrophysics Data System (ADS)
Tantawi, Sami G.; Tamura, Fumihiko
2000-04-01
We describe the potential of semiconductor X-band RF switch arrays as a means of developing high power RF pulse compression systems for future linear colliders. The switch systems described here have two designs. Both designs consist of two 3dB hybrids and active modules. In the first design the module is composed of a cascaded active phase shifter. In the second design the module uses arrays of SPST (Single Pole Single Throw) switches. Each cascaded element of the phase shifter and the SPST switch has similar design. The active element consists of symmetrical three-port tee-junctions and an active waveguide window in the symmetrical arm of the tee-junction. The design methodology of the elements and the architecture of the whole switch system are presented. We describe the scaling law that governs the relation between power handling capability and number of elements. The design of the active waveguide window is presented. The waveguide window is a silicon wafer with an array of four hundred PIN/NIP diodes covering the surface of the window. This waveguide window is located in an over-moded TE01 circular waveguide. The results of high power RF measurements of the active waveguide window are presented. The experiment is performed at power levels of tens of megawatts at X-band.
Laser modulator for LISA pathfinder
NASA Astrophysics Data System (ADS)
Voland, C.; Lund, G.; Coppoolse, W.; Crosby, P.; Stadler, M.; Kudielka, K.; Özkan, C.
2017-11-01
LISA Pathfinder is an ESA experiment to demonstrate the key technologies needed for the LISA mission to detect gravitational waves in space. The LISA Pathfinder spacecraft represents one arm of the LISA interferometer, containing an optical metrology system and two proof masses as inertial references for the drag-free control system. The LISA Pathfinder payload consists of two drag-free floating test masses located in the inertial sensors with their control electronics and an optical metrology subsystem. The optical metrology subsystem monitors the movement of both test masses relative to each other and to the spacecraft with very high sensitivity and resolution. This is achieved with a heterodyne Mach- Zehnder interferometer. This interferometer requires as input two coherent laser beams with a heterodyne frequency difference of a few kHz. To generate the two laser beams with a heterodyne frequency difference a Nd:YAG laser is used together with the Laser Modulator. The Nd:YAG laser generates a single coherent laser signal at a wavelength of 1064nm which is fibre coupled to the Laser Modulator. The Laser Modulator then generates the two optical beams with the required heterodyne frequency offset. In addition, the Laser Modulator is required to perform laser amplitude stabilization and optical path difference control for the two optical signals. The Laser Modulator consists of an optical unit - the LMU - and RF synthesiser, power amplification and control electronics. These electronics are all housed in the Laser Modulator Electronics (LME). The LMU has four primary functions: • Splitting of the input laser beam into two paths for later superposition in the interferometer. • Applying different frequency shifts to each of the beams. • Providing amplitude modulation control to each of the beams. • Providing active control of the optical path length difference between the two optical paths. The present paper describes the design and performance of the LMU
Energetics of an rf SQUID Coupled to Two Thermal Reservoirs
Gardas, B.; Łuczka, J.; Ptok, A.; ...
2015-12-07
We study energetics of a Josephson tunnel junction connecting a superconducting loop pierced by an external magnetic flux (an rf SQUID) and coupled to two independent thermal reservoirs of different temperature. In the framework of the theory of quantum dissipative systems, we analyze energy currents in stationary states. The stationary energy flow can be periodically modulated by the external magnetic flux exemplifying the rf SQUID as a quantum heat interferometer. Additionally, we consider the transient regime and identify three distinct regimes: monotonic decay, damped oscillations and pulse-type behavior of energy currents. Furthermore, the first two regimes can be controlled bymore » the external magnetic flux while the last regime is robust against its variation.« less
NASA Astrophysics Data System (ADS)
Qiu, Zhaoyang; Wang, Pei; Zhu, Jun; Tang, Bin
2016-12-01
Nyquist folding receiver (NYFR) is a novel ultra-wideband receiver architecture which can realize wideband receiving with a small amount of equipment. Linear frequency modulated/binary phase shift keying (LFM/BPSK) hybrid modulated signal is a novel kind of low probability interception signal with wide bandwidth. The NYFR is an effective architecture to intercept the LFM/BPSK signal and the LFM/BPSK signal intercepted by the NYFR will add the local oscillator modulation. A parameter estimation algorithm for the NYFR output signal is proposed. According to the NYFR prior information, the chirp singular value ratio spectrum is proposed to estimate the chirp rate. Then, based on the output self-characteristic, matching component function is designed to estimate Nyquist zone (NZ) index. Finally, matching code and subspace method are employed to estimate the phase change points and code length. Compared with the existing methods, the proposed algorithm has a better performance. It also has no need to construct a multi-channel structure, which means the computational complexity for the NZ index estimation is small. The simulation results demonstrate the efficacy of the proposed algorithm.
Frequency-dependent tACS modulation of BOLD signal during rhythmic visual stimulation.
Chai, Yuhui; Sheng, Jingwei; Bandettini, Peter A; Gao, Jia-Hong
2018-05-01
Transcranial alternating current stimulation (tACS) has emerged as a promising tool for modulating cortical oscillations. In previous electroencephalogram (EEG) studies, tACS has been found to modulate brain oscillatory activity in a frequency-specific manner. However, the spatial distribution and hemodynamic response for this modulation remains poorly understood. Functional magnetic resonance imaging (fMRI) has the advantage of measuring neuronal activity in regions not only below the tACS electrodes but also across the whole brain with high spatial resolution. Here, we measured fMRI signal while applying tACS to modulate rhythmic visual activity. During fMRI acquisition, tACS at different frequencies (4, 8, 16, and 32 Hz) was applied along with visual flicker stimulation at 8 and 16 Hz. We analyzed the blood-oxygen-level-dependent (BOLD) signal difference between tACS-ON vs tACS-OFF, and different frequency combinations (e.g., 4 Hz tACS, 8 Hz flicker vs 8 Hz tACS, 8 Hz flicker). We observed significant tACS modulation effects on BOLD responses when the tACS frequency matched the visual flicker frequency or the second harmonic frequency. The main effects were predominantly seen in regions that were activated by the visual task and targeted by the tACS current distribution. These findings bridge different scientific domains of tACS research and demonstrate that fMRI could localize the tACS effect on stimulus-induced brain rhythms, which could lead to a new approach for understanding the high-level cognitive process shaped by the ongoing oscillatory signal. © 2018 Wiley Periodicals, Inc.
A noncontact RF-based respiratory sensor: results of a clinical trial.
Madsen, Spence; Baczuk, Jordan; Thorup, Kurt; Barton, Richard; Patwari, Neal; Langell, John T
2016-06-01
Respiratory rate (RR) is a critical vital signs monitored in health care setting. Current monitors suffer from sensor-contact failure, inaccurate data, and limited patient mobility. There is a critical need for an accurate and reliable and noncontact system to monitor RR. We developed a contact-free radio frequency (RF)-based system that measures movement using WiFi signal diffraction, which is converted into interpretable data using a Fourier transform. Here, we investigate the system's ability to measure fine movements associated with human respiration. Testing was conducted on subjects using visual cue, fixed-tempo instruction to breath at standard RRs. Blinded instruction-based RRs were compared to RF-acquired data to determine measurement accuracy. The RF-based technology was studied on postoperative ventilator-dependent patients. Blinded ventilator capnographic RR data were collected for each patient and compared to RF-acquired data to determine measurement accuracy. Respiratory rate data collected from 10 subjects breathing at a fixed RR (14, 16, 18, or 20) demonstrated 95.5% measurement accuracy between the patient's actual rate and that measured by our RF technology. Ten patients were enrolled into the clinical trial. Blinded ventilator capnographic RR data were compared to RF-based acquired data. The RF-based data showed 88.8% measurement accuracy with ventilator capnography. Initial clinical pilot trials with our contact-free RF-based monitoring system demonstrate a high degree of RR measurement accuracy when compared to capnographic data. Based on these results, we believe RF-based systems present a promising noninvasive, inexpensive, and accurate tool for continuous RR monitoring. Copyright © 2016 Elsevier Inc. All rights reserved.
Saez-Rodriguez, Julio; Gayer, Stefan; Ginkel, Martin; Gilles, Ernst Dieter
2008-08-15
The modularity of biochemical networks in general, and signaling networks in particular, has been extensively studied over the past few years. It has been proposed to be a useful property to analyze signaling networks: by decomposing the network into subsystems, more manageable units are obtained that are easier to analyze. While many powerful algorithms are available to identify modules in protein interaction networks, less attention has been paid to signaling networks de.ned as chemical systems. Such a decomposition would be very useful as most quantitative models are de.ned using the latter, more detailed formalism. Here, we introduce a novel method to decompose biochemical networks into modules so that the bidirectional (retroactive) couplings among the modules are minimized. Our approach adapts a method to detect community structures, and applies it to the so-called retroactivity matrix that characterizes the couplings of the network. Only the structure of the network, e.g. in SBML format, is required. Furthermore, the modularized models can be loaded into ProMoT, a modeling tool which supports modular modeling. This allows visualization of the models, exploiting their modularity and easy generation of models of one or several modules for further analysis. The method is applied to several relevant cases, including an entangled model of the EGF-induced MAPK cascade and a comprehensive model of EGF signaling, demonstrating its ability to uncover meaningful modules. Our approach can thus help to analyze large networks, especially when little a priori knowledge on the structure of the network is available. The decomposition algorithms implemented in MATLAB (Mathworks, Inc.) are freely available upon request. ProMoT is freely available at http://www.mpi-magdeburg.mpg.de/projects/promot. Supplementary data are available at Bioinformatics online.
NASA Technical Reports Server (NTRS)
Downey, Joseph A.
2004-01-01
adding a 200 watt Dornier tube to the Varian and Logimetrics combined setup for a total of 400 watts. After that we will use two 200 watt Dorniers for 400 watts and eventually four 200 watt Dornier tubes to demonstrate 800 watts. After demonstrating the success of power combining, we will need to verify the integrity of a modulated signal sent through the combined tubes. The purpose will be to see what effects separating and recombining will have on the modulated signal and also what effect it will have on combining efficiency. A Bit Error Rate (BER) will be determined by a Bit Error Rate Tester (BERT) by comparing the random information it transmits to what it receives back. The process began with two 100 watt tubes, a Varian and a Logimetrics, salvaged
Annexins - scaffolds modulating PKC localization and signaling.
Hoque, Monira; Rentero, Carles; Cairns, Rose; Tebar, Francesc; Enrich, Carlos; Grewal, Thomas
2014-06-01
Spatial and temporal organization of signal transduction is critical to link different extracellular stimuli with distinct cellular responses. A classical example of hormones and growth factors creating functional diversity is illustrated by the multiple signaling pathways activated by the protein kinase C (PKC) family of serine/threonine protein kinases. The molecular requirements for diacylglycerol (DAG) and calcium (Ca(2+)) to promote PKC membrane translocation, the hallmark of PKC activation, have been clarified. However, the underlying mechanisms that establish selectivity of individual PKC family members to facilitate differential substrate phosphorylation and varied signal output are still not fully understood. It is now well believed that the coordinated control and functional diversity of PKC signaling involves the formation of PKC isozyme-specific protein complexes in certain subcellular sites. In particular, interaction of PKC isozymes with compartment and signal-organizing scaffolds, including receptors for activated C-kinase (RACKs), A-kinase-anchoring proteins (AKAPs), 14-3-3, heat shock proteins (HSP), and importins target PKC isozymes to specific cellular locations, thereby delivering PKC isozymes into close proximity of their substrates. In addition, several annexins (Anx), including AnxA1, A2, A5 and A6, display specific and distinct abilities to interact and promote membrane targeting of different PKC isozymes. Together with the ability of annexins to create specific membrane microenvironments, this is likely to enable PKCs to phosphorylate certain substrates and regulate their downstream effector pathways in specific cellular sites. This review aims to summarize the capacity of annexins to modulate the localization and activity of PKC family members and participate in the spatiotemporal regulation of PKC signaling in health and disease. Copyright © 2014 Elsevier Inc. All rights reserved.
NASA Astrophysics Data System (ADS)
Duckitt, W. D.; Conradie, J. L.; van Niekerk, M. J.; Abraham, J. K.; Niesler, T. R.
2018-07-01
iThemba LABS has successfully designed a new broadband digital low-level RF control system for cyclotrons, that operates over the wide frequency range of 2-100 MHz and can achieve peak-peak amplitude and phase stabilities of 0.01% and 0.01°, respectively. The presented system performs direct digital synthesis (DDS) to directly convert the digital RF signals to analog RF and local-oscillator (LO) signals with 16-bit amplitude accuracy, programmable in steps of 1 μHz and 0.0001°. Down-conversion of the RF pick-up signals to an optimal intermediate frequency (IF) of 1 MHz and sampling of the IF channels by 16-bit, single sample-latency 10 MHz ADCs was implemented to allow digital high-speed low-latency in-phase/quadrature (I/Q) demodulation of the IF channels within the FPGA. This in turn allows efficient real-time digital closed-loop control of the amplitude and phase of the RF drive-signal to be achieved. The systems have been successfully integrated at iThemba LABS into the K = 8 and K = 10 injector cyclotrons (SPC1, and SPC2), the K = 200 separated sector cyclotron (SSC), the SSC flat-topping system, the pulse-selector system and the AX , J, and K-line RF bunchers. The systems have led to a substantial improvement in the beam quality of the SSC at iThemba LABS with a reduction in beam losses by more than 90%. The design, implementation and performance is discussed.
Miniaturized magnet-less RF electron trap. II. Experimental verification
Deng, Shiyang; Green, Scott R.; Markosyan, Aram H.; ...
2017-06-15
Atomic microsystems have the potential of providing extremely accurate measurements of timing and acceleration. But, atomic microsystems require active maintenance of ultrahigh vacuum in order to have reasonable operating lifetimes and are particularly sensitive to magnetic fields that are used to trap electrons in traditional sputter ion pumps. Our paper presents an approach to trapping electrons without the use of magnetic fields, using radio frequency (RF) fields established between two perforated electrodes. The challenges associated with this magnet-less approach, as well as the miniaturization of the structure, are addressed. These include, for example, the transfer of large voltage (100–200 V)more » RF power to capacitive loads presented by the structure. The electron trapping module (ETM) described here uses eight electrode elements to confine and measure electrons injected by an electron beam, within an active trap volume of 0.7 cm 3. The operating RF frequency is 143.6 MHz, which is the measured series resonant frequency between the two RF electrodes. It was found experimentally that the steady state electrode potentials on electrodes near the trap became more negative after applying a range of RF power levels (up to 0.15 W through the ETM), indicating electron densities of ≈3 × 10 5 cm -3 near the walls of the trap. The observed results align well with predicted electron densities from analytical and numerical models. The peak electron density within the trap is estimated as ~1000 times the electron density in the electron beam as it exits the electron gun. Finally, this successful demonstration of the RF electron trapping concept addresses critical challenges in the development of miniaturized magnet-less ion pumps.« less
NASA Astrophysics Data System (ADS)
Chakraborty, Avik; Sarkar, Angsuman
2015-04-01
In this paper, the analog/RF performance of an III-V semiconductor based staggered hetero-tunnel-junction (HETJ) n-type nanowire (NW) tunneling FET (n-TFET) is investigated, for the first time. The device performance figure-of-merits governing the analog/RF performance such as transconductance (gm), transconductance-to-drive current ratio (gm/IDS), output resistance (Rout), intrinsic gain and unity-gain cutoff frequency (fT) have been studied. The analog/RF performance parameters is compared between HETJ NW TFET and a homojunction (HJ) NW n-type TFET of similar dimensions. In addition to enhanced ION and subthreshold swing, a significant improvement in the analog/RF performance parameters obtained by the HETJ n-TFET over HJ counterpart for use in analog/mixed signal System-on-Chip (SoC) applications is reported. Moreover, the analog/RF performance parameters of a III-V based staggered HETJ NW TFET is also compared with a heterojunction (HETJ) NW n-type MOSFET having same material as HETJ n-TFET and equal dimension in order to provide a systematic comparison between HETJ-TFET and HETJ-MOSFET for use in analog/mixed-signal applications. The results reveal that HETJ n-TFET provides higher Rout and hence, a higher intrinsic gain, an improved gm/IDS ratio, and reasonable fT at lower values of gate-overdrive voltage as compared to the HETJ NW n-MOSFET.
Interpretation of fast-ion signals during beam modulation experiments
Heidbrink, W. W.; Collins, C. S.; Stagner, L.; ...
2016-07-22
Fast-ion signals produced by a modulated neutral beam are used to infer fast-ion transport. The measured quantity is the divergence of perturbed fast-ion flux from the phase-space volume measured by the diagnostic, ∇•more » $$\\bar{Γ}$$. Since velocity-space transport often contributes to this divergence, the phase-space sensitivity of the diagnostic (or “weight function”) plays a crucial role in the interpretation of the signal. The source and sink make major contributions to the signal but their effects are accurately modeled by calculations that employ an exponential decay term for the sink. Recommendations for optimal design of a fast-ion transport experiment are given, illustrated by results from DIII-D measurements of fast-ion transport by Alfv´en eigenmodes. Finally, the signal-to-noise ratio of the diagnostic, systematic uncertainties in the modeling of the source and sink, and the non-linearity of the perturbation all contribute to the error in ∇•$$\\bar{Γ}$$.« less
RF-photonic chirp encoder and compressor for seamless analysis of information flow.
Zalevsky, Zeev; Shemer, Amir; Zach, Shlomo
2008-05-26
In this paper we realize an RF photonic chirp compression system that compresses a continuous stream of incoming RF data (modulated on top of an optical carrier) into a train of temporal short pulses. Each pulse in the train can be separated and treated individually while being sampled by low rate optical switch and without temporal loses of the incoming flow of information. Each such pulse can be filtered and analyzed differently. The main advantage of the proposed system is its capability of being able to handle, seamlessly, high rate information flow with all-optical means and with low rate optical switches.
NASA Astrophysics Data System (ADS)
Wang, Ping; Zha, Hao; Syratchev, Igor; Shi, Jiaru; Chen, Huaibi
2017-11-01
We present an X-band high-power pulse compression system for a klystron-based compact linear collider. In this system design, one rf power unit comprises two klystrons, a correction cavity chain, and two SLAC Energy Doubler (SLED)-type X-band pulse compressors (SLEDX). An rf pulse passes the correction cavity chain, by which the pulse shape is modified. The rf pulse is then equally split into two ways, each deploying a SLEDX to compress the rf power. Each SLEDX produces a short pulse with a length of 244 ns and a peak power of 217 MW to power four accelerating structures. With the help of phase-to-amplitude modulation, the pulse has a dedicated shape to compensate for the beam loading effect in accelerating structures. The layout of this system and the rf design and parameters of the new pulse compressor are described in this work.
RF wave observations in beam-plasma discharge
NASA Technical Reports Server (NTRS)
Bernstein, W.
1986-01-01
The Beam Plasma Discharge (BPD) was produced in the large vacuum chamber at Johnson Space Center (20 x 30 m) using an energetic electron beam of moderately high perveance. A more complete expression of the threshold current I sub c taking into account the pitch angle injection dependence is given. Ambient plasma density inferred from wave measurements under various beam conditions are reported. Maximum frequency of the excited RF band behaves differently than the frequency of the peak amplitude. The latter shows signs of parabolic saturation consistent with the light data. Beam plasma state (pre-BPD or BPD) does not affect the pitch angle dependence. Unexpected strong modulation of the RF spectrum at half odd integer of the electron cyclotron frequency (n + 1/2)f sub ce is reported (5 n 10). Another new feature, the presence of wave emission around 3/2 f sub ce for I sub b is approximate I sub c is reported.
Environmental signals modulate ToxT-dependent virulence factor expression in Vibrio cholerae.
Schuhmacher, D A; Klose, K E
1999-03-01
The regulatory protein ToxT directly activates the transcription of virulence factors in Vibrio cholerae, including cholera toxin (CT) and the toxin-coregulated pilus (TCP). Specific environmental signals stimulate virulence factor expression by inducing the transcription of toxT. We demonstrate that transcriptional activation by the ToxT protein is also modulated by environmental signals. ToxT expressed from an inducible promoter activated high-level expression of CT and TCP in V. cholerae at 30 degrees C, but expression of CT and TCP was significantly decreased or abolished by the addition of 0.4% bile to the medium and/or an increase of the temperature to 37 degrees C. Also, expression of six ToxT-dependent TnphoA fusions was modulated by temperature and bile. Measurement of ToxT-dependent transcription of genes encoding CT and TCP by ctxAp- and tcpAp-luciferase fusions confirmed that negative regulation by 37 degrees C or bile occurs at the transcriptional level in V. cholerae. Interestingly, ToxT-dependent transcription of these same promoters in Salmonella typhimurium was relatively insensitive to regulation by temperature or bile. These data are consistent with ToxT transcriptional activity being modulated by environmental signals in V. cholerae and demonstrate an additional level of complexity governing the expression of virulence factors in this pathogen. We propose that negative regulation of ToxT-dependent transcription by environmental signals prevents the incorrect temporal and spatial expression of virulence factors during cholera pathogenesis.
A space-based classification system for RF transients
NASA Astrophysics Data System (ADS)
Moore, K. R.; Call, D.; Johnson, S.; Payne, T.; Ford, W.; Spencer, K.; Wilkerson, J. F.; Baumgart, C.
The FORTE (Fast On-Orbit Recording of Transient Events) small satellite is scheduled for launch in mid 1995. The mission is to measure and classify VHF (30-300 MHz) electromagnetic pulses, primarily due to lightning, within a high noise environment dominated by continuous wave carriers such as TV and FM stations. The FORTE Event Classifier will use specialized hardware to implement signal processing and neural network algorithms that perform onboard classification of RF transients and carriers. Lightning events will also be characterized with optical data telemetered to the ground. A primary mission science goal is to develop a comprehensive understanding of the correlation between the optical flash and the VHF emissions from lightning. By combining FORTE measurements with ground measurements and/or active transmitters, other science issues can be addressed. Examples include the correlation of global precipitation rates with lightning flash rates and location, the effects of large scale structures within the ionosphere (such as traveling ionospheric disturbances and horizontal gradients in the total electron content) on the propagation of broad bandwidth RF signals, and various areas of lightning physics. Event classification is a key feature of the FORTE mission. Neural networks are promising candidates for this application. The authors describe the proposed FORTE Event Classifier flight system, which consists of a commercially available digital signal processing board and a custom board, and discuss work on signal processing and neural network algorithms.
Rf2a and rf2b transcription factors
Beachy, Roger N.; Petruccelli, Silvana; Dai, Shunhong
2007-10-02
A method of activating the rice tungro bacilliform virus (RTBV) promoter in vivo is disclosed. The RTBV promoter is activated by exposure to at least one protein selected from the group consisting of Rf2a and Rf2b.
Thermally Stabilized Transmit/Receive Modules
NASA Technical Reports Server (NTRS)
Hoffman, James; DelCastillo, Linda; Miller, Jennifer; Birur, Gaj
2011-01-01
RF-hybrid technologies enable smaller packaging and mass reduction in radar instruments, especially for subsystems with dense electronics, such as electronically steered arrays. We are designing thermally stabilized RF-hybrid T/R modules using new materials for improved thermal performance of electronics. We are combining advanced substrate and housing materials with a thermal reservoir material, and develop new packaging techniques to significantly improve thermal-cycling reliability and performance stability over temperature.
NASA Technical Reports Server (NTRS)
Britt, C. L., Jr.
1975-01-01
The development of an RF Multilateration system to provide accurate position and velocity measurements during the approach and landing phase of Vertical Takeoff Aircraft operation is discussed. The system uses an angle-modulated ranging signal to provide both range and range rate measurements between an aircraft transponder and multiple ground stations. Range and range rate measurements are converted to coordinate measurements and the coordinate and coordinate rate information is transmitted by an integral data link to the aircraft. Data processing techniques are analyzed to show advantages and disadvantages. Error analyses are provided to permit a comparison of the various techniques.
Multimode intravascular RF coil for MRI-guided interventions.
Kurpad, Krishna N; Unal, Orhan
2011-04-01
To demonstrate the feasibility of using a single intravascular radiofrequency (RF) probe connected to the external magnetic resonance imaging (MRI) system via a single coaxial cable to perform active tip tracking and catheter visualization and high signal-to-noise ratio (SNR) intravascular imaging. A multimode intravascular RF coil was constructed on a 6F balloon catheter and interfaced to a 1.5T MRI scanner via a decoupling circuit. Bench measurements of coil impedances were followed by imaging experiments in saline and phantoms. The multimode coil behaves as an inductively coupled transmit coil. The forward-looking capability of 6 mm was measured. A greater than 3-fold increase in SNR compared to conventional imaging using optimized external coil was demonstrated. Simultaneous active tip tracking and catheter visualization was demonstrated. It is feasible to perform 1) active tip tracking, 2) catheter visualization, and 3) high SNR imaging using a single multimode intravascular RF coil that is connected to the external system via a single coaxial cable. Copyright © 2011 Wiley-Liss, Inc.
The effect of interference on delta modulation encoded video signals
NASA Technical Reports Server (NTRS)
Schilling, D. L.
1979-01-01
An adaptive delta modulator which encodes composite color video signals was shown to provide a good response when operating at 16 Mb/s and near-commercial quality at 23Mb/s. The ADM was relatively immune to channel errors. The system design is discussed and circuit diagrams are included.
NASA Astrophysics Data System (ADS)
Song, Ickhyun; Cho, Moon-Kyu; Oakley, Michael A.; Ildefonso, Adrian; Ju, Inchan; Buchner, Stephen P.; McMorrow, Dale; Paki, Pauline; Cressler, John. D.
2017-05-01
Best practice in mitigation strategies for single-event transients (SETs) in radio-frequency (RF) receiver modules is investigated using a variety of integrated receivers utilizing inverse-mode silicon-germanium (SiGe) heterojunction bipolar transistors (HBTs). The receivers were designed and implemented in a 130-nm SiGe BiCMOS technology platform. In general, RF switches, low-noise amplifiers (LNAs), and downconversion mixers utilizing inverse-mode SiGe HBTs exhibit less susceptibility to SETs than conventional RF designs, in terms of transient peaks and duration, at the cost of RF performance. Under normal RF operation, the SET-hardened switch is mainly effective in peak reduction, while the LNA and the mixer exhibit reductions in transient peaks as well as transient duration.
Ion source with external RF antenna
Leung, Ka-Ngo; Ji, Qing; Wilde, Stephen
2005-12-13
A radio frequency (RF) driven plasma ion source has an external RF antenna, i.e. the RF antenna is positioned outside the plasma generating chamber rather than inside. The RF antenna is typically formed of a small diameter metal tube coated with an insulator. An external RF antenna assembly is used to mount the external RF antenna to the ion source. The RF antenna tubing is wound around the external RF antenna assembly to form a coil. The external RF antenna assembly is formed of a material, e.g. quartz, which is essentially transparent to the RF waves. The external RF antenna assembly is attached to and forms a part of the plasma source chamber so that the RF waves emitted by the RF antenna enter into the inside of the plasma chamber and ionize a gas contained therein. The plasma ion source is typically a multi-cusp ion source.
Sub-micron resolution rf cavity beam position monitor system at the SACLA XFEL facility
NASA Astrophysics Data System (ADS)
Maesaka, H.; Ego, H.; Inoue, S.; Matsubara, S.; Ohshima, T.; Shintake, T.; Otake, Y.
2012-12-01
We have developed and constructed a C-band (4.760 GHz) rf cavity beam position monitor (RF-BPM) system for the XFEL facility at SPring-8, SACLA. The demanded position resolution of the RF-BPM is less than 1 μm, because an electron beam and x-rays must be overlapped within 4 μm precision in the undulator section for sufficient FEL interaction between the electrons and x-rays. In total, 57 RF-BPMs, including IQ demodulators and high-speed waveform digitizers for signal processing, were produced and installed into SACLA. We evaluated the position resolutions of 20 RF-BPMs in the undulator section by using a 7 GeV electron beam having a 0.1 nC bunch charge. The position resolution was measured to be less than 0.6 μm, which was sufficient for the XFEL lasing in the wavelength region of 0.1 nm, or shorter.
Ancho Canyon RF Collect, March 2, 2017: Final Report
DOE Office of Scientific and Technical Information (OSTI.GOV)
Junor, William; Layne, John Preston; Gamble, Thomas Kirk
2017-09-21
We report the results from the March 2, 2017, Ancho Canyon RF collection. While bright electromagnetic signals were seen nearby the firing point, there were no detections of signals from the explosively-fired fuse at a collection point about 570m distant on the East Mesa. However, "liveness" tests of the East Mesa data acquisition system and checks of the timing both suggest that the collection system was working correctly. We examine possible reasons for the lack of detection. Principal among these is that the impulsive signal may be small compared to the radio frequency background on the East Mesa.
Loran digital phase-locked loop and RF front-end system error analysis
NASA Technical Reports Server (NTRS)
Mccall, D. L.
1979-01-01
An analysis of the system performance of the digital phase locked loops (DPLL) and RF front end that are implemented in the MINI-L4 Loran receiver is presented. Three of the four experiments deal with the performance of the digital phase locked loops. The other experiment deals with the RF front end and DPLL system error which arise in the front end due to poor signal to noise ratios. The ability of the DPLLs to track the offsets is studied.
Universal sensor interface module (USIM)
NASA Astrophysics Data System (ADS)
King, Don; Torres, A.; Wynn, John
1999-01-01
A universal sensor interface model (USIM) is being developed by the Raytheon-TI Systems Company for use with fields of unattended distributed sensors. In its production configuration, the USIM will be a multichip module consisting of a set of common modules. The common module USIM set consists of (1) a sensor adapter interface (SAI) module, (2) digital signal processor (DSP) and associated memory module, and (3) a RF transceiver model. The multispectral sensor interface is designed around a low-power A/D converted, whose input/output interface consists of: -8 buffered, sampled inputs from various devices including environmental, acoustic seismic and magnetic sensors. The eight sensor inputs are each high-impedance, low- capacitance, differential amplifiers. The inputs are ideally suited for interface with discrete or MEMS sensors, since the differential input will allow direct connection with high-impedance bridge sensors and capacitance voltage sources. Each amplifier is connected to a 22-bit (Delta) (Sigma) A/D converter to enable simultaneous samples. The low power (Delta) (Sigma) converter provides 22-bit resolution at sample frequencies up to 142 hertz (used for magnetic sensors) and 16-bit resolution at frequencies up to 1168 hertz (used for acoustic and seismic sensors). The video interface module is based around the TMS320C5410 DSP. It can provide sensor array addressing, video data input, data calibration and correction. The processor module is based upon a MPC555. It will be used for mode control, synchronization of complex sensors, sensor signal processing, array processing, target classification and tracking. Many functions of the A/D, DSP and transceiver can be powered down by using variable clock speeds under software command or chip power switches. They can be returned to intermediate or full operation by DSP command. Power management may be based on the USIM's internal timer, command from the USIM transceiver, or by sleep mode processing management
RF study and 3-D simulations of a side-coupling thermionic RF-gun
NASA Astrophysics Data System (ADS)
Rimjaem, S.; Kusoljariyakul, K.; Thongbai, C.
2014-02-01
A thermionic RF-gun for generating ultra-short electron bunches was optimized, developed and used as a source at a linac-based THz radiation research laboratory of the Plasma and Beam Physics Research Facility, Chiang Mai University, Thailand. The RF-gun is a π/2-mode standing wave structure, which consists of two S-band accelerating cells and a side-coupling cavity. The 2856 MHz RF wave is supplied from an S-band klystron to the gun through the waveguide input-port at the cylindrical wall of the second cell. A fraction of the RF power is coupled from the second cell to the first one via a side-coupling cavity. Both the waveguide input-port and the side-coupling cavity lead to an asymmetric geometry of the gun. RF properties and electromagnetic field distributions inside the RF-gun were studied and numerically simulated by using computer codes SUPERFISH 7.19 and CST Microwave Studio 2012©. RF characterizations and tunings of the RF-gun were performed to ensure the reliability of the gun operation. The results from 3D simulations and measurements are compared and discussed in this paper. The influence of asymmetric field distributions inside the RF-gun on the electron beam properties was investigated via 3D beam dynamics simulations. A change in the coupling-plane of the side-coupling cavity is suggested to improve the gun performance.
NASA Technical Reports Server (NTRS)
Porter, J. A.; Gibson, J. S.; Kroll, Q. D.; Loh, Y. C.
1981-01-01
The RF communications capabilities and nominally expected performance for the ascent phase of the second orbital flight of the shuttle are provided. Predicted performance is given mainly in the form of plots of signal strength versus elapsed mission time for the STDN (downlink) and shuttle orbiter (uplink) receivers for the S-band PM and FM, and UHF systems. Performance of the NAV and landing RF systems is treated for RTLS abort, since in this case the spacecraft will loop around and return to the launch site. NAV and landing RF systems include TACAN, MSBLS, and C-band altimeter. Signal strength plots were produced by a computer program which combines the spacecraft trajectory, antenna patterns, transmit and receive performance characteristics, and system mathematical models. When available, measured spacecraft parameters were used in the predictions; otherwise, specified values were used. Specified ground station parameter values were also used. Thresholds and other criteria on the graphs are explained.
Full wave modulator-demodulator amplifier apparatus. [for generating rectified output signal
NASA Technical Reports Server (NTRS)
Black, J. M. (Inventor)
1974-01-01
A full-wave modulator-demodulator apparatus is described including an operational amplifier having a first input terminal coupled to a circuit input terminal, and a second input terminal alternately coupled to the circuit input terminal. A circuit is ground by a switching circuit responsive to a phase reference signal and the operational amplifier is alternately switched between a non-inverting mode and an inverting mode. The switching circuit includes three field-effect transistors operatively associated to provide the desired switching function in response to an alternating reference signal of the same frequency as an AC input signal applied to the circuit input terminal.
Li, Zhe; Erkilinc, M Sezer; Galdino, Lidia; Shi, Kai; Thomsen, Benn C; Bayvel, Polina; Killey, Robert I
2016-12-12
Single-polarization direct-detection transceivers may offer advantages compared to digital coherent technology for some metro, back-haul, access and inter-data center applications since they offer low-cost and complexity solutions. However, a direct-detection receiver introduces nonlinearity upon photo detection, since it is a square-law device, which results in signal distortion due to signal-signal beat interference (SSBI). Consequently, it is desirable to develop effective and low-cost SSBI compensation techniques to improve the performance of such transceivers. In this paper, we compare the performance of a number of recently proposed digital signal processing-based SSBI compensation schemes, including the use of single- and two-stage linearization filters, an iterative linearization filter and a SSBI estimation and cancellation technique. Their performance is assessed experimentally using a 7 × 25 Gb/s wavelength division multiplexed (WDM) single-sideband 16-QAM Nyquist-subcarrier modulation system operating at a net information spectral density of 2.3 (b/s)/Hz.
Negative ion kinetics in RF glow discharges
DOE Office of Scientific and Technical Information (OSTI.GOV)
Gottscho, R.A.; Gacbe, C.E.
1986-04-01
Using temporally and spatially resolved laser spectroscopy, the authors have determined the identities, approximate concentrations, effects on the local field, and kinetics of formation and loss of negative ions in RF discharges. CI/sup -/ and BCI/sub 3//sup -/ are the dominant negative ions found in low-frequency discharges through CI/sub 2/ and BCI/sub 3/, respectively. The electron affinity for CI is measured to be 3.6118 +- 0.0005 eV. Negative ion kinetics are strongly affected by application of the RF field. Formation of negative ions by attachment of slow electrons in RF discharges is governed by the extent and duration of electronmore » energy relaxation. Similarly, destruction of negative ions by collisional detachment and field extraction is dependent upon ion energy modulation. Thus, at low frequency, the anion density peaks at the beginning of the anodic and cathodic half-cycles after electrons have attached but before detachment and extraction have had time to occur. At higher frequencies, electrons have insufficient time to attach before they are reheated and the instantaneous anion density in the sheath is greatly reduced. When the negative ion density is comparable to the positive ion density, the plasma potential is observed to lie below the anode potential, double layers form between sheath and plasma, and anions and electrons are accelerated by large sheath fields to electrode surfaces.« less
Noncoherent Tracking of a Source of a Data-Modulated Signal
NASA Technical Reports Server (NTRS)
Arndt, G. Dickey; Ngo, Phong; Chen, Henry; Phan, Chau T.; Hill, Brent; Bourgeois, Brian; Dusl, John
2003-01-01
A proposed tracking receiver system containing three suitably positioned antenna elements and special signal-processing equipment would determine the direction of incidence of a microwave signal containing spread-spectrum digital data modulation. If the system were to contain two sets of antenna elements separated by a known baseline, it could determine the location of the transmitter as the intersection of the lines of incidence on the two antennas. Such systems could be used for diverse purposes in outer space and on Earth, including tracking astronauts and small robotic spacecraft working outside a spacecraft or space station, and locating cellular telephones from which distress calls have been made. The principle of operation does not require the transmission of a special identifying or distress signal by the cellular telephone or other transmitter to be tracked; instead, the system could utilize the data signal routinely sent by the transmitter, provided that the signal had the characteristics needed for processing.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hashimoto, Yoshifumi; Kumagai, Naomichi; Hosoda, Nao
2014-03-14
Highlights: • So far, eRF3 has been thought to function exclusively in the cytoplasm. • eRF3 is a nucleo-cutoplasmic shuttling protein. • eRF3 has a leptomycin-sensitive nuclear export signal (NES). • Removal of NES by proteolytic cleavage allows eRF3 to translocate to the nucleus. • The processed eRF3 (p-eRF3) interacts with a nuclear tumor suppressor ARF. - Abstract: The eukaryotic releasing factor eRF3 is a multifunctional protein that plays pivotal roles in translation termination as well as the initiation of mRNA decay. eRF3 also functions in the regulation of apoptosis; eRF3 is cleaved at Ala73 by an as yet unidentifiedmore » protease into processed isoform of eRF3 (p-eRF3), which interacts with the inhibitors of apoptosis proteins (IAPs). The binding of p-eRF3 with IAPs leads to the release of active caspases from IAPs, which promotes apoptosis. Although full-length eRF3 is localized exclusively in the cytoplasm, p-eRF3 localizes in the nucleus as well as the cytoplasm. We here focused on the role of p-eRF3 in the nucleus. We identified leptomycin-sensitive nuclear export signal (NES) at amino acid residues 61–71 immediately upstream of the cleavage site Ala73. Thus, the proteolytic cleavage of eRF3 into p-eRF3 leads to release an amino-terminal fragment containing NES to allow the relocalization of eRF3 into the nucleus. Consistent with this, p-eRF3 more strongly interacted with the nuclear ARF tumor suppressor than full-length eRF3. These results suggest that while p-eRF3 interacts with IAPs to promote apoptosis in the cytoplasm, p-eRF3 also has some roles in regulating cell death in the nucleus.« less
NASA Astrophysics Data System (ADS)
Hasan, Mehedi; Maldonado-Basilio, Ramón; Hall, Trevor J.
2015-04-01
Yin et al. have described an innovative filter-less optical millimeter-wave generation scheme for octotupling of a 10 GHz RF oscillator, or sedecimtupling of a 5 GHz RF oscillator using two parallel dual-parallel Mach-Zehnder modulators (DP-MZMs). The great merit of their design is the suppression of all harmonics except those of order ? (octotupling) or all harmonics except those of order ? (sedecimtupling), where ? is an integer. A demerit of their scheme is the requirement to set a precise RF signal modulation index in order to suppress the zeroth order optical carrier. The purpose of this comment is to show that, in the case of the octotupling function, all harmonics may be suppressed except those of order ?, where ? is an odd integer, by the simple addition of an optical ? phase shift between the two DP-MZMs and an adjustment of the RF drive phases. Since the carrier is suppressed in the modified architecture, the octotupling circuit is thereby released of the strict requirement to set the drive level to a precise value without any significant increase in circuit complexity.
Detector power linearity requirements and verification techniques for TMI direct detection receivers
NASA Technical Reports Server (NTRS)
Reinhardt, Victor S. (Inventor); Shih, Yi-Chi (Inventor); Toth, Paul A. (Inventor); Reynolds, Samuel C. (Inventor)
1997-01-01
A system (36, 98) for determining the linearity of an RF detector (46, 106). A first technique involves combining two RF signals from two stable local oscillators (38, 40) to form a modulated RF signal having a beat frequency, and applying the modulated RF signal to a detector (46) being tested. The output of the detector (46) is applied to a low frequency spectrum analyzer (48) such that a relationship between the power levels of the first and second harmonics generated by the detector (46) of the beat frequency of the modulated RF signal are measured by the spectrum analyzer (48) to determine the linearity of the detector (46). In a second technique, an RF signal from a local oscillator (100) is applied to a detector (106) being tested through a first attenuator (102) and a second attenuator (104). The output voltage of the detector (106) is measured when the first attenuator (102) is set to a particular attenuation value and the second attenuator (104) is switched between first and second attenuation values. Further, the output voltage of the detector (106) is measured when the first attenuator (102) is set to another attenuation value, and the second attenuator (104) is again switched between the first and second attenuation values. A relationship between the voltage outputs determines the linearity of the detector (106).
Safavi-Naeini, Payam; Zafar-Awan, Dreema; Zhu, Hongjian; Zablah, Gerardo; Ganapathy, Anand V; Rasekh, Abdi; Saeed, Mohammad; Razavi, Joanna Esther Molina; Razavi, Mehdi
2017-01-01
Current methods for measuring voltage during radiofrequency (RF) ablation (RFA) necessitate turning off the ablation catheter. If voltage could be accurately read without signal attenuation during RFA, turning off the catheter would be unnecessary, allowing continuous ablation. We evaluated the accuracy of the Thermocool SMARTTOUCH catheter for measuring voltage while RF traverses the catheter. We studied 26 patients undergoing RFA for arrhythmias. A 7.5F SMARTTOUCH catheter was used for sensing voltage and performing RFA. Data were collected from the Carto-3 3-dimensional mapping system. Voltages were measured during ablation (RF-ON) and immediately before or after ablation (RF-OFF). In evaluating the accuracy of RF-ON measurements, we utilized the RF-OFF measure as the gold standard. We measured 465 voltage signals. The median values were 0.2900 and 0.3100 for RF-ON and RF-OFF, respectively. Wilcoxon signed rank testing showed no significant difference in these values (P = 0.608). The intraclass correlation coefficient (ICC) was 0.96, indicating that voltage measurements were similarly accurate during RF-OFF versus RF-ON. Five patients had baseline atrial fibrillation (AF), for whom 82 ablation points were measured; 383 additional ablation points were measured for the remaining patients. The voltages measured during RF-ON versus RF-OFF were similar in the presence of AF (P = 0.800) versus non-AF rhythm (P = 0.456) (ICC, 0.96 for both). Voltage signal measurement was similarly accurate during RF-ON versus RF-OFF independent of baseline rhythm. Physicians should consider not turning off the SMARTTOUCH ablation catheter when measuring voltage during RFA. © 2016 Wiley Periodicals, Inc.
Ring modulator small-signal response analysis based on pole-zero representation.
Karimelahi, Samira; Sheikholeslami, Ali
2016-04-04
We present a closed-form expression for the small-signal response of a depletion-mode ring modulator and verify it by measurement results. Both electrical and optical behavior of micro-ring modulator as well as the loss variation due to the index modulation is considered in the derivation. This expression suggests that a ring modulator is a third-order system with one real pole, one zero and a pair of complex-conjugate poles. The exact positions of the poles/zero are given and shown to be dependent upon parameters such as electrical bandwidth, coupling condition, optical loss, and sign/value of laser detunings. We show that the location of zero is different for positive and negative detuning, and therefore, the ring modulator frequency response is asymmetric. We use the gain-bandwidth product as a figure of merit and calculate it for various pole/zero locations. We show that gain-bandwidth for the over-coupled ring modulator is superior compared to other coupling conditions. Also, we show that the gain-bandwidth product can be increased to a limit by increasing the electrical bandwidth.
On the power spectral density of quadrature modulated signals. [satellite communication
NASA Technical Reports Server (NTRS)
Yan, T. Y.
1981-01-01
The conventional (no-offset) quadriphase modulation technique suffers from the fact that hardlimiting will restore the frequency sidelobes removed by proper filtering. Thus, offset keyed quadriphase modulation techniques are often proposed for satellite communication with bandpass hardlimiting. A unified theory is developed which is capable of describing the power spectral density before and after the hardlimiting process. Using the in-phase and the quadrature phase channel with arbitrary pulse shaping, analytical results are established for generalized quadriphase modulation. In particular MSK, OPSK or the recently introduced overlapped raised cosine keying all fall into this general category. It is shown that for a linear communication channel, the power spectral density of the modulated signal remains unchanged regardless of the offset delay. Furthermore, if the in phase and the quadrature phase channel have identical pulse shapes without offset, the spectrum after bandpass hardlimiting will be identical to that of the conventional QPSK modulation. Numerical examples are given for various modulation techniques. A case of different pulse shapes in the in phase and the quadrature phase channel is also considered.
NASA Astrophysics Data System (ADS)
Martinez, Luis A.; Castelli, Alessandro R.; Delmas, William; Sharping, Jay E.; Chiao, Raymond
2016-11-01
We present experimental and theoretical results for the excitation of a mechanical oscillator via radiation pressure with a room-temperature system employing a relatively low-(Q) centimeter-size mechanical oscillator coupled to a relatively low-Q standard three-dimensional radio-frequency (RF) cavity resonator. We describe the forces giving rise to optomechanical coupling using the Maxwell stress tensor and show that nanometer-scale displacements are possible and experimentally observable. The experimental system is composed of a 35 mm diameter silicon nitride membrane sputtered with a 300 nm gold conducting film and attached to the end of a RF copper cylindrical cavity. The RF cavity is operated in its {{TE}}011 mode and amplitude modulated on resonance with the fundamental drum modes of the membrane. Membrane motion is monitored using an unbalanced, non-zero optical path difference, optically filtered Michelson interferometer capable of measuring sub-nanometer displacements.
Design and status of the RF-digitizer integrated circuit
NASA Technical Reports Server (NTRS)
Rayhrer, B.; Lam, B.; Young, L. E.; Srinivasan, J. M.; Thomas, J. B.
1991-01-01
An integrated circuit currently under development samples a bandpass-limited signal at a radio frequency in quadrature and then performs a simple sum-and-dump operation in order to filter and lower the rate of the samples. Downconversion to baseband is carried out by the sampling step itself through the aliasing effect of an appropriately selected subharmonic sampling frequency. Two complete RF digitizer circuits with these functions will be implemented with analog and digital elements on one GaAs substrate. An input signal, with a carrier frequency as high as 8 GHz, can be sampled at a rate as high as 600 Msamples/sec for each quadrature component. The initial version of the chip will sign-sample (1-bit) the input RF signal. The chip will contain a synthesizer to generate a sample frequency that is a selectable integer multiple of an input reference frequency. In addition to the usual advantages of compactness and reliability associated with integrated circuits, the single chip will replace several steps required by standard analog downconversion. Furthermore, when a very high initial sample rate is selected, the presampling analog filters can be given very large bandwidths, thereby greatly reducing phase and delay instabilities typically introduced by such filters, as well as phase and delay variation due to Doppler changes.
Modulation of hippocampal neural plasticity by glucose-related signaling.
Mainardi, Marco; Fusco, Salvatore; Grassi, Claudio
2015-01-01
Hormones and peptides involved in glucose homeostasis are emerging as important modulators of neural plasticity. In this regard, increasing evidence shows that molecules such as insulin, insulin-like growth factor-I, glucagon-like peptide-1, and ghrelin impact on the function of the hippocampus, which is a key area for learning and memory. Indeed, all these factors affect fundamental hippocampal properties including synaptic plasticity (i.e., synapse potentiation and depression), structural plasticity (i.e., dynamics of dendritic spines), and adult neurogenesis, thus leading to modifications in cognitive performance. Here, we review the main mechanisms underlying the effects of glucose metabolism on hippocampal physiology. In particular, we discuss the role of these signals in the modulation of cognitive functions and their potential implications in dysmetabolism-related cognitive decline.
NASA Astrophysics Data System (ADS)
El-Nahal, Fady I.
2017-01-01
We investigate a wavelength-division-multiplexing passive optical network (WDM-PON) with centralized lightwave and direct detection. The system is demonstrated for symmetric 10 Gbit/s differential phase-shift keying (DPSK) downstream signals and on-off keying (OOK) upstream signals, respectively. A wavelength reused scheme is employed to carry the upstream data by using a reflective semiconductor optical amplifier (RSOA) as an intensity modulator at the optical network unit (ONU). The constant-intensity property of the DPSK modulation format can keep high extinction ratio ( ER) of downstream signal and reduce the crosstalk to the upstream signal. The bit error rate ( BER) performance of our scheme shows that the proposed 10 Gbit/s symmetric WDM-PON can achieve error free transmission over 25-km-long fiber transmission with low power penalty.
NASA Astrophysics Data System (ADS)
Wu, Peng; Ma, Jianxin
2017-03-01
We have proposed and demonstrated a scheme to generate a frequency-sextupling amplitude shift keying (ASK)-single sideband optical millimeter (mm)-wave signal with high dispersion tolerance based on an optical phase modulator (PM) by ably using the-4th-order and +2nd-order sidebands of the optical modulation. The ASK radio frequency signal, superposed by a local oscillator with the same frequency, modulates the lightwave via an optical PM with proper voltage amplitudes, the +2nd-order sideband carries the ASK signal with a constant slope while the -4th-order sideband maintains constant amplitude. These two sidebands can be abstracted by a wavelength selective switch to form a dual-tone optical mm-wave with only one tone carrying the ASK signal. As only one tone bears the ASK signal while the other tone is unmodulated, the generated dual-tone optical mm-wave signal has high dispersion tolerance.
NASA Astrophysics Data System (ADS)
Yi, Xiaoqing; Hao, Liling; Jiang, Fangfang; Xu, Lisheng; Song, Shaoxiu; Li, Gang; Lin, Ling
2017-08-01
Synchronous acquisition of multi-channel biopotential signals, such as electrocardiograph (ECG) and electroencephalograph, has vital significance in health care and clinical diagnosis. In this paper, we proposed a new method which is using single channel ADC to acquire multi-channel biopotential signals modulated by square waves synchronously. In this method, a specific modulate and demodulate method has been investigated without complex signal processing schemes. For each channel, the sampling rate would not decline with the increase of the number of signal channels. More specifically, the signal-to-noise ratio of each channel is n times of the time-division method or an improvement of 3.01 ×log2n dB, where n represents the number of the signal channels. A numerical simulation shows the feasibility and validity of this method. Besides, a newly developed 8-lead ECG based on the new method has been introduced. These experiments illustrate that the method is practicable and thus is potential for low-cost medical monitors.
NASA Astrophysics Data System (ADS)
Menon, Govind; Krishnan, J.
2016-07-01
While signalling and biochemical modules have been the focus of numerous studies, they are typically studied in isolation, with no examination of the effects of the ambient network. In this paper we formulate and develop a systems framework, rooted in dynamical systems, to understand such effects, by studying the interaction of signalling modules. The modules we consider are (i) basic covalent modification, (ii) monostable switches, (iii) bistable switches, (iv) adaptive modules, and (v) oscillatory modules. We systematically examine the interaction of these modules by analyzing (a) sequential interaction without shared components, (b) sequential interaction with shared components, and (c) oblique interactions. Our studies reveal that the behaviour of a module in isolation may be substantially different from that in a network, and explicitly demonstrate how the behaviour of a given module, the characteristics of the ambient network, and the possibility of shared components can result in new effects. Our global approach illuminates different aspects of the structure and functioning of modules, revealing the importance of dynamical characteristics as well as biochemical features; this provides a methodological platform for investigating the complexity of natural modules shaped by evolution, elucidating the effects of ambient networks on a module in multiple cellular contexts, and highlighting the capabilities and constraints for engineering robust synthetic modules. Overall, such a systems framework provides a platform for bridging the gap between non-linear information processing modules, in isolation and as parts of networks, and a basis for understanding new aspects of natural and engineered cellular networks.
Menon, Govind; Krishnan, J
2016-07-21
While signalling and biochemical modules have been the focus of numerous studies, they are typically studied in isolation, with no examination of the effects of the ambient network. In this paper we formulate and develop a systems framework, rooted in dynamical systems, to understand such effects, by studying the interaction of signalling modules. The modules we consider are (i) basic covalent modification, (ii) monostable switches, (iii) bistable switches, (iv) adaptive modules, and (v) oscillatory modules. We systematically examine the interaction of these modules by analyzing (a) sequential interaction without shared components, (b) sequential interaction with shared components, and (c) oblique interactions. Our studies reveal that the behaviour of a module in isolation may be substantially different from that in a network, and explicitly demonstrate how the behaviour of a given module, the characteristics of the ambient network, and the possibility of shared components can result in new effects. Our global approach illuminates different aspects of the structure and functioning of modules, revealing the importance of dynamical characteristics as well as biochemical features; this provides a methodological platform for investigating the complexity of natural modules shaped by evolution, elucidating the effects of ambient networks on a module in multiple cellular contexts, and highlighting the capabilities and constraints for engineering robust synthetic modules. Overall, such a systems framework provides a platform for bridging the gap between non-linear information processing modules, in isolation and as parts of networks, and a basis for understanding new aspects of natural and engineered cellular networks.
RF slice profile effects in magnetic resonance fingerprinting.
Hong, Taehwa; Han, Dongyeob; Kim, Min-Oh; Kim, Dong-Hyun
2017-09-01
The radio frequency (RF) slice profile effects on T1 and T2 estimation in magnetic resonance fingerprinting (MRF) are investigated with respect to time-bandwidth product (TBW), flip angle (FA) level and field inhomogeneities. Signal evolutions are generated incorporating the non-ideal slice selective excitation process using Bloch simulation and matched to the original dictionary with and without the non-ideal slice profile taken into account. For validation, phantom and in vivo experiments are performed at 3T. Both simulations and experiments results show that T1 and T2 error from non-ideal slice profile increases with increasing FA level, off-resonance, and low TBW values. Therefore, RF slice profile effects should be compensated for accurate determination of the MR parameters. Copyright © 2017 Elsevier Inc. All rights reserved.
The NF-YC–RGL2 module integrates GA and ABA signalling to regulate seed germination in Arabidopsis
Liu, Xu; Hu, Pengwei; Huang, Mingkun; Tang, Yang; Li, Yuge; Li, Ling; Hou, Xingliang
2016-01-01
The antagonistic crosstalk between gibberellic acid (GA) and abscisic acid (ABA) plays a pivotal role in the modulation of seed germination. However, the molecular mechanism of such phytohormone interaction remains largely elusive. Here we show that three Arabidopsis NUCLEAR FACTOR-Y C (NF-YC) homologues NF-YC3, NF-YC4 and NF-YC9 redundantly modulate GA- and ABA-mediated seed germination. These NF-YCs interact with the DELLA protein RGL2, a key repressor of GA signalling. The NF-YC–RGL2 module targets ABI5, a gene encoding a core component of ABA signalling, via specific CCAAT elements and collectively regulates a set of GA- and ABA-responsive genes, thus controlling germination. These results suggest that the NF-YC–RGL2–ABI5 module integrates GA and ABA signalling pathways during seed germination. PMID:27624486
Feasibility study of a new RF coil design for prostate MRI
NASA Astrophysics Data System (ADS)
Ha, Seunghoon; Roeck, Werner W.; Cho, Jaedu; Nalcioglu, Orhan
2014-09-01
The combined use of a torso-pelvic RF array coil and endorectal RF coil is the current state-of-the-art in prostate MRI. The endorectal coil provides high detection sensitivity to acquire high-spatial resolution images and spectroscopic data, while the torso-pelvic coil provides large coverage to assess pelvic lymph nodes and pelvic bones for metastatic disease. However, the use of an endorectal coil is an invasive procedure that presents difficulties for both patients and technicians. In this study, we propose a novel non-invasive RF coil design that can provide both image signal to noise ratio and field of view coverage comparable to the combined torso-pelvic and endorectal coil configuration. A prototype coil was constructed and tested using a pelvic phantom. The results demonstrate that this new design is a viable alternative for prostate MRI
Welchko, Brian A [Torrance, CA
2012-02-14
Systems and methods are provided for pulse-width modulated control of power inverter using phase-shifted carrier signals. An electrical system comprises an energy source and a motor. The motor has a first set of windings and a second set of windings, which are electrically isolated from each other. An inverter module is coupled between the energy source and the motor and comprises a first set of phase legs coupled to the first set of windings and a second set of phase legs coupled to the second set of windings. A controller is coupled to the inverter module and is configured to achieve a desired power flow between the energy source and the motor by modulating the first set of phase legs using a first carrier signal and modulating the second set of phase legs using a second carrier signal. The second carrier signal is phase-shifted relative to the first carrier signal.
Proposal for an optical multicarrier generator based on single silicon micro-ring modulator
NASA Astrophysics Data System (ADS)
Bhowmik, Bishanka Brata; Gupta, Sumanta
2015-08-01
We propose an optical multicarrier generation technique using silicon micro-ring modulator (MRM) and analyze the scheme. Numerical studies have been done for three types MRMs having different power coupling coefficients. The proposed scheme is found to generate four optical carriers having 12.5 GHz spacing. According to simulation, the maximum side-mode-suppression ratio (SMSR) of ~16.3 dB with flatness of ~0.2 dB is achieved by using this scheme. The minimum extinction ratio (ER) of the generated carriers is found to be more than 35 dB. We also propose modulator driver circuit to generate RF signal, which is needed to generate multicarrier using MRM. The effect of coupling coefficient on the SMSR of the generated carriers is also investigated.
NASA Technical Reports Server (NTRS)
Ely, Jay J.; Nguyen, Truong X.; Scearce, Stephen A.
2000-01-01
For electromagnetic immunity testing of an electronic system, it is desirable to demonstrate its functional integrity when exposed to the full range and intensity of environmental electromagnetic threats that may be encountered over its operational life. As part of this, it is necessary to show proper system operation when exposed to representative threat signal modulations. Modulated signal transition time is easily overlooked, but can be highly significant to system susceptibility. Radiated electromagnetic field immunity testing is increasingly being performed in Mode Stirred Chambers. Because the peak field vs. time relationship is affected by the operation of a reverberating room, it is important to understand how the room may influence any input signal modulation characteristics. This paper will provide insight into the field intensity vs. time relationship within the test environment of a mode stirred chamber. An understanding of this relationship is important to EMC engineers in determining what input signal modulation characteristics will be transferred to the equipment under test. References will be given for the development of this topic, and experimental data will be presented
An Overview of the MaRIE X-FEL and Electron Radiography LINAC RF Systems
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bradley, Joseph Thomas III; Rees, Daniel Earl; Scheinker, Alexander
The purpose of the Matter-Radiation Interactions in Extremes (MaRIE) facility at Los Alamos National Laboratory is to investigate the performance limits of materials in extreme environments. The MaRIE facility will utilize a 12 GeV linac to drive an X-ray Free-Electron Laser (FEL). Most of the same linac will also be used to perform electron radiography. The main linac is driven by two shorter linacs; one short linac optimized for X-FEL pulses and one for electron radiography. The RF systems have historically been the one of the largest single component costs of a linac. We will describe the details of themore » different types of RF systems required by each part of the linacs. Starting with the High Power RF system, we will present our methodology for the choice of RF system peak power and pulselength with respect to klystron parameters, modulator parameters, performance requirements and relative costs. We will also present an overview of the Low Level RF systems that are proposed for MaRIE and briefly describe their use with some proposed control schemes.« less
Wei, Fang; Lu, Bin; Wang, Jian; Xu, Dan; Pan, Zhengqing; Chen, Dijun; Cai, Haiwen; Qu, Ronghui
2015-02-23
A precision and broadband laser frequency swept technique is experimentally demonstrated. Using synchronous current compensation, a slave diode laser is dynamically injection-locked to a specific high-order modulation-sideband of a narrow-linewidth master laser modulated by an electro-optic modulator (EOM), whose driven radio frequency (RF) signal can be agilely, precisely controlled by a frequency synthesizer, and the high-order modulation-sideband enables multiplied sweep range and tuning rate. By using 5th order sideband injection-locking, the original tuning range of 3 GHz and tuning rate of 0.5 THz/s is multiplied by 5 times to 15 GHz and 2.5 THz/s respectively. The slave laser has a 3 dB-linewidth of 2.5 kHz which is the same to the master laser. The settling time response of a 10 MHz frequency switching is 2.5 µs. By using higher-order modulation-sideband and optimized experiment parameters, an extended sweep range and rate could be expected.
NASA Astrophysics Data System (ADS)
Butkowski, Łukasz; Vogel, Vladimir; Schlarb, Holger; Szabatin, Jerzy
2017-06-01
The driving engine of the superconducting accelerator of the European X-ray free electron laser (XFEL) is a set of 27 radio frequency (RF) stations. Each of the underground RF stations consists of a multibeam horizontal klystron that can provide up to 10 MW of power at 1.3 GHz. Klystrons are sensitive devices with a limited lifetime and a high mean time between failures. In real operation, the lifetime of the tube can be significantly reduced because of failures. The special fast protection klystron lifetime management (KLM) system has been developed to minimize the influence of service conditions on the lifetime of klystrons. The main task of this system is to detect all events which can destroy the tube as quickly as possible, and switch off the driving RF signal or the high voltage. Detection of events is based on a comparison of the value of the real signal obtained at the system output with the value estimated on the basis of a high-power RF amplifier model and input signals. The KLM system has been realized in field-programmable gate array (FPGA) and implemented in XFEL. Implementation is based on the standard low-level RF micro telecommunications computing architecture (MTCA.4 or xTCA). The main part of the paper focuses on an estimation of the klystron model and the implementation of KLM in FPGA. The results of the performance of the KLM system will also be presented.
Meisel, Joshua D.; Panda, Oishika; Mahanti, Parag; Schroeder, Frank C.; Kim, Dennis H.
2014-01-01
Summary Discrimination among pathogenic and beneficial microbes is essential for host organism immunity and homeostasis. Here, we show that chemosensory detection of two secondary metabolites produced by Pseudomonas aeruginosa modulates a neuroendocrine signaling pathway that promotes avoidance behavior in the simple animal host Caenorhabditis elegans. Secondary metabolites phenazine-1-carboxamide and pyochelin activate a G protein-signaling pathway in the ASJ chemosensory neuron pair that induces expression of the neuromodulator DAF-7/TGF-β. DAF-7, in turn, activates a canonical TGF-β signaling pathway in adjacent interneurons to modulate aerotaxis behavior and promote avoidance of pathogenic P. aeruginosa. Our data provide a chemical, genetic, and neuronal basis for how the behavior and physiology of a simple animal host can be modified by the microbial environment, and suggest that secondary metabolites produced by microbes may provide environmental cues that contribute to pathogen recognition and host survival. PMID:25303524
RF wave simulation for cold edge plasmas using the MFEM library
NASA Astrophysics Data System (ADS)
Shiraiwa, S.; Wright, J. C.; Bonoli, P. T.; Kolev, T.; Stowell, M.
2017-10-01
A newly developed generic electro-magnetic (EM) simulation tool for modeling RF wave propagation in SOL plasmas is presented. The primary motivation of this development is to extend the domain partitioning approach for incorporating arbitrarily shaped SOL plasmas and antenna to the TORIC core ICRF solver, which was previously demonstrated in the 2D geometry [S. Shiraiwa, et. al., "HISTORIC: extending core ICRF wave simulation to include realistic SOL plasmas", Nucl. Fusion in press], to larger and more complicated simulations by including a 3D realistic antenna and integrating RF rectified sheath potential model. Such an extension requires a scalable high fidelity 3D edge plasma wave simulation. We used the MFEM [
Infrared Avionics Signal Distribution Using WDM
NASA Technical Reports Server (NTRS)
Atiquzzaman, Mohammed; Sluss, James J., Jr.
2004-01-01
Supporting analog RF signal transmission over optical fibers, this project demonstrates a successful application of wavelength division multiplexing (WDM) to the avionics environment. We characterize the simultaneous transmission of four RF signals (channels) over a single optical fiber. At different points along a fiber optic backbone, these four analog channels are sequentially multiplexed and demultiplexed to more closely emulate the conditions in existing onboard aircraft. We present data from measurements of optical power, transmission response (loss and gain), reflection response, group delay that defines phase distortion, signal-to-noise ratio (SNR), and dynamic range that defines nonlinear distortion. The data indicate that WDM is very suitable for avionics applications.
Dual-function photonic integrated circuit for frequency octo-tupling or single-side-band modulation.
Hasan, Mehedi; Maldonado-Basilio, Ramón; Hall, Trevor J
2015-06-01
A dual-function photonic integrated circuit for microwave photonic applications is proposed. The circuit consists of four linear electro-optic phase modulators connected optically in parallel within a generalized Mach-Zehnder interferometer architecture. The photonic circuit is arranged to have two separate output ports. A first port provides frequency up-conversion of a microwave signal from the electrical to the optical domain; equivalently single-side-band modulation. A second port provides tunable millimeter wave carriers by frequency octo-tupling of an appropriate amplitude RF carrier. The circuit exploits the intrinsic relative phases between the ports of multi-mode interference couplers to provide substantially all the static optical phases needed. The operation of the proposed dual-function photonic integrated circuit is verified by computer simulations. The performance of the frequency octo-tupling and up-conversion functions is analyzed in terms of the electrical signal to harmonic distortion ratio and the optical single side band to unwanted harmonics ratio, respectively.
Accuracy of WAAS-Enabled GPS-RF Warning Signals When Crossing a Terrestrial Geofence
Grayson, Lindsay M.; Keefe, Robert F.; Tinkham, Wade T.; Eitel, Jan U. H.; Saralecos, Jarred D.; Smith, Alistair M. S.; Zimbelman, Eloise G.
2016-01-01
Geofences are virtual boundaries based on geographic coordinates. When combined with global position system (GPS), or more generally global navigation satellite system (GNSS) transmitters, geofences provide a powerful tool for monitoring the location and movements of objects of interest through proximity alarms. However, the accuracy of geofence alarms in GNSS-radio frequency (GNSS-RF) transmitter receiver systems has not been tested. To achieve these goals, a cart with a GNSS-RF locator was run on a straight path in a balanced factorial experiment with three levels of cart speed, three angles of geofence intersection, three receiver distances from the track, and three replicates. Locator speed, receiver distance and geofence intersection angle all affected geofence alarm accuracy in an analysis of variance (p = 0.013, p = 2.58 × 10−8, and p = 0.0006, respectively), as did all treatment interactions (p < 0.0001). Slower locator speed, acute geofence intersection angle, and closest receiver distance were associated with reduced accuracy of geofence alerts. PMID:27322287
Accuracy of WAAS-Enabled GPS-RF Warning Signals When Crossing a Terrestrial Geofence.
Grayson, Lindsay M; Keefe, Robert F; Tinkham, Wade T; Eitel, Jan U H; Saralecos, Jarred D; Smith, Alistair M S; Zimbelman, Eloise G
2016-06-18
Geofences are virtual boundaries based on geographic coordinates. When combined with global position system (GPS), or more generally global navigation satellite system (GNSS) transmitters, geofences provide a powerful tool for monitoring the location and movements of objects of interest through proximity alarms. However, the accuracy of geofence alarms in GNSS-radio frequency (GNSS-RF) transmitter receiver systems has not been tested. To achieve these goals, a cart with a GNSS-RF locator was run on a straight path in a balanced factorial experiment with three levels of cart speed, three angles of geofence intersection, three receiver distances from the track, and three replicates. Locator speed, receiver distance and geofence intersection angle all affected geofence alarm accuracy in an analysis of variance (p = 0.013, p = 2.58 × 10(-8), and p = 0.0006, respectively), as did all treatment interactions (p < 0.0001). Slower locator speed, acute geofence intersection angle, and closest receiver distance were associated with reduced accuracy of geofence alerts.
Ka-Band Link Study and Analysis for a Mars Hybrid RF/Optical Software Defined Radio
NASA Technical Reports Server (NTRS)
Zeleznikar, Daniel J.; Nappier, Jennifer M.; Downey, Joseph A.
2014-01-01
The integrated radio and optical communications (iROC) project at the NASA Glenn Research Center (GRC) is investigating the feasibility of a hybrid RF and optical communication subsystem for future deep space missions. The hybrid communications subsystem enables the advancement of optical communications while simultaneously mitigating the risk of infusion by combining an experimental optical transmitter and telescope with a reliable Ka-band RF transmitter and antenna. The iROC communications subsystem seeks to maximize the total data return over the course of a potential 2-year mission in Mars orbit beginning in 2021. Although optical communication by itself offers potential for greater data return over RF, the reliable Ka-band link is also being designed for high data return capability in this hybrid system. A daily analysis of the RF link budget over the 2-year span is performed to optimize and provide detailed estimates of the RF data return. In particular, the bandwidth dependence of these data return estimates is analyzed for candidate waveforms. In this effort, a data return modeling tool was created to analyze candidate RF modulation and coding schemes with respect to their spectral efficiency, amplifier output power back-off, required digital to analog conversion (DAC) sampling rates, and support by ground receivers. A set of RF waveforms is recommended for use on the iROC platform.
NASA Astrophysics Data System (ADS)
Yu, Wan-Ting; Yu, Hong-yi; Du, Jian-Ping; Wang, Ding
2018-04-01
The Direct Position Determination (DPD) algorithm has been demonstrated to achieve a better accuracy with known signal waveforms. However, the signal waveform is difficult to be completely known in the actual positioning process. To solve the problem, we proposed a DPD method for digital modulation signals based on improved particle swarm optimization algorithm. First, a DPD model is established for known modulation signals and a cost function is obtained on symbol estimation. Second, as the optimization of the cost function is a nonlinear integer optimization problem, an improved Particle Swarm Optimization (PSO) algorithm is considered for the optimal symbol search. Simulations are carried out to show the higher position accuracy of the proposed DPD method and the convergence of the fitness function under different inertia weight and population size. On the one hand, the proposed algorithm can take full advantage of the signal feature to improve the positioning accuracy. On the other hand, the improved PSO algorithm can improve the efficiency of symbol search by nearly one hundred times to achieve a global optimal solution.
Simulations of S-band RF gun with RF beam control
NASA Astrophysics Data System (ADS)
Barnyakov, A. M.; Levichev, A. E.; Maltseva, M. V.; Nikiforov, D. A.
2017-08-01
The RF gun with RF control is discussed. It is based on the RF triode and two kinds of the cavities. The first cavity is a coaxial cavity with cathode-grid assembly where beam bunches are formed, the second one is an accelerating cavity. The features of such a gun are the following: bunched and relativistic beams in the output of the injector, absence of the back bombarding electrons, low energy spread and short length of the bunches. The scheme of the injector is shown. The electromagnetic field simulation and longitudinal beam dynamics are presented. The possible using of the injector is discussed.
An MR/MRI compatible core holder with the RF probe immersed in the confining fluid.
Shakerian, M; Balcom, B J
2018-01-01
An open frame RF probe for high pressure and high temperature MR/MRI measurements was designed, fabricated, and tested. The open frame RF probe was installed inside an MR/MRI compatible metallic core holder, withstanding a maximum pressure and temperature of 5000 psi and 80 °C. The open frame RF probe was tunable for both 1 H and 19 F resonance frequencies with a 0.2 T static magnetic field. The open frame structure was based on simple pillars of PEEK polymer upon which the RF probe was wound. The RF probe was immersed in the high pressure confining fluid during operation. The open frame structure simplified fabrication of the RF probe and significantly reduced the amount of polymeric materials in the core holder. This minimized the MR background signal detected. Phase encoding MRI methods were employed to map the spin density of a sulfur hexafluoride gas saturating a Berea core plug in the core holder. The SF 6 was imaged as a high pressure gas and as a supercritical fluid. Copyright © 2017 Elsevier Inc. All rights reserved.
An MR/MRI compatible core holder with the RF probe immersed in the confining fluid
NASA Astrophysics Data System (ADS)
Shakerian, M.; Balcom, B. J.
2018-01-01
An open frame RF probe for high pressure and high temperature MR/MRI measurements was designed, fabricated, and tested. The open frame RF probe was installed inside an MR/MRI compatible metallic core holder, withstanding a maximum pressure and temperature of 5000 psi and 80 °C. The open frame RF probe was tunable for both 1H and 19F resonance frequencies with a 0.2 T static magnetic field. The open frame structure was based on simple pillars of PEEK polymer upon which the RF probe was wound. The RF probe was immersed in the high pressure confining fluid during operation. The open frame structure simplified fabrication of the RF probe and significantly reduced the amount of polymeric materials in the core holder. This minimized the MR background signal detected. Phase encoding MRI methods were employed to map the spin density of a sulfur hexafluoride gas saturating a Berea core plug in the core holder. The SF6 was imaged as a high pressure gas and as a supercritical fluid.
Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets
Ahmad, Faiyaz; Murata, Taku; Simizu, Kasumi; Degerman, Eva; Maurice, Donald; Manganiello, Vincent
2014-01-01
By catalyzing hydrolysis of cAMP and cGMP, cyclic nucleotide phosphodiesterases are critical regulators of their intracellular concentrations and their biological effects. Since these intracellular second messengers control many cellular homeostatic processes, dysregulation of their signals and signaling pathways initiate or modulate pathophysiological pathways related to various disease states, including erectile dysfunction, pulmonary hypertension, acute refractory cardiac failure, intermittent claudication, chronic obstructive pulmonary disease, and psoriasis. Alterations in expression of PDEs and PDE-gene mutations (especially mutations in PDE6, PDE8B, PDE11A and PDE4) have been implicated in various diseases and cancer pathologies. PDEs also play important role in formation and function of multi-molecular signaling/regulatory complexes called signalosomes. At specific intracellular locations, individual PDEs, together with pathway-specific signaling molecules, regulators, and effectors, are incorporated into specific signalosomes, where they facilitate and regulate compartmentalization of cyclic nucleotide signaling pathways and specific cellular functions. Currently, only a limited number of PDE inhibitors (PDE3, PDE4, PDE5 inhibitors) are used in clinical practice. Future paths to novel drug discovery include the crystal structure-based design approach, which has resulted in generation of more effective family-selective inhibitors, as well as burgeoning development of strategies to alter compartmentalized cyclic nucleotide signaling pathways by selectively targeting individual PDEs and their signalosome partners. PMID:25056711
Arrays of Carbon Nanotubes as RF Filters in Waveguides
NASA Technical Reports Server (NTRS)
Hoppe, Daniel; Hunt, Brian; Hoenk, Michael; Noca, Flavio; Xu, Jimmy
2003-01-01
Brushlike arrays of carbon nanotubes embedded in microstrip waveguides provide highly efficient (high-Q) mechanical resonators that will enable ultraminiature radio-frequency (RF) integrated circuits. In its basic form, this invention is an RF filter based on a carbon nanotube array embedded in a microstrip (or coplanar) waveguide, as shown in Figure 1. In addition, arrays of these nanotube-based RF filters can be used as an RF filter bank. Applications of this new nanotube array device include a variety of communications and signal-processing technologies. High-Q resonators are essential for stable, low-noise communications, and radar applications. Mechanical oscillators can exhibit orders of magnitude higher Qs than electronic resonant circuits, which are limited by resistive losses. This has motivated the development of a variety of mechanical resonators, including bulk acoustic wave (BAW) resonators, surface acoustic wave (SAW) resonators, and Si and SiC micromachined resonators (known as microelectromechanical systems or MEMS). There is also a strong push to extend the resonant frequencies of these oscillators into the GHz regime of state-of-the-art electronics. Unfortunately, the BAW and SAW devices tend to be large and are not easily integrated into electronic circuits. MEMS structures have been integrated into circuits, but efforts to extend MEMS resonant frequencies into the GHz regime have been difficult because of scaling problems with the capacitively-coupled drive and readout. In contrast, the proposed devices would be much smaller and hence could be more readily incorporated into advanced RF (more specifically, microwave) integrated circuits.
ALTERATIONS IN CALCIUM ION ACTIVITY BY ELF AND RF ELECTROMAGNETIC FIELDS
Alterations in calcium ion activity by ELF and RF electromagnetic fields
Introduction
Calcium ions play many important roles in biological systems. For example, calcium ion activity can be used as an indicator of second-messenger signal-transduction processe...
NASA Astrophysics Data System (ADS)
Tian, Bo; Zhang, Qi; Ma, Jianxin; Tao, Ying; Shen, Yufei; Wang, Yang; Zhang, Geng; Zhou, Wenmao; Zhao, Yi; Pan, Xiaolong
2018-07-01
A polarization division multiplexed (PDM) microwave photonic link for the millimeter (MM)-wave signal with hybrid modulation scheme is proposed in this paper, which is based on the combination of quadrature amplitude modulation, multi-pulse pulse-position modulation and return to zero modulation (QAM-MPPM-RZ). In this scheme, the two orthogonal polarization states enable simultaneous transmission of four data flows, which can provide different services for users according to the data rate requirement. To generate hybrid QAM-MPPM-RZ mm-wave signal, the QAM mm-wave signal is directly modulated by MPPM-RZ signal without using digital signal processing (DSP) devices, which reduces the overhead of the encoding process. Then, the generated QAM-MPPM-RZ mm-wave signal is transmitted in PDM microwave photonic link based on SSB modulation. The sparsity characteristic of QAM-MPPM-RZ not only improves the power efficiency, but also decreases the degradation caused by the fiber chromatic dispersion. The simulation results show that, under the constraint of the same transmitted data rate, the PDM microwave photonic link with 50 GHz QAM-MPPM-RZ mm-wave signal achieves much lower levels of bit-error rate than ordinary 32-QAM. In addition, the increase of laser linewidth brings no additional impact to the proposed scheme.
A molecular-sized optical logic circuit for digital modulation of a fluorescence signal
NASA Astrophysics Data System (ADS)
Nishimura, Takahiro; Tsuchida, Karin; Ogura, Yusuke; Tanida, Jun
2018-03-01
Fluorescence measurement allows simultaneous detection of multiple molecular species by using spectrally distinct fluorescence probes. However, due to the broad spectra of fluorescence emission, the multiplicity of fluorescence measurement is generally limited. To overcome this limitation, we propose a method to digitally modulate fluorescence output signals with a molecular-sized optical logic circuit by using optical control of fluorescence resonance energy transfer (FRET). The circuit receives a set of optical inputs represented with different light wavelengths, and then it switches high and low fluorescence intensity from a reporting molecule according to the result of the logic operation. By using combinational optical inputs in readout of fluorescence signals, the number of biomolecular species that can be identified is increased. To implement the FRET-based circuits, we designed two types of basic elements, YES and NOT switches. An YES switch produces a high-level output intensity when receiving a designated light wavelength input and a low-level intensity without the light irradiation. A NOT switch operates inversely to the YES switch. In experiments, we investigated the operation of the YES and NOT switches that receive a 532-nm light input and modulate the fluorescence intensity of Alexa Fluor 488. The experimental result demonstrates that the switches can modulate fluorescence signals according to the optical input.
Fiber optic crossbar switch for automatically patching optical signals
NASA Technical Reports Server (NTRS)
Bell, C. H. (Inventor)
1983-01-01
A system for automatically optically switching fiber optic data signals between a plurality of input optical fibers and selective ones of a plurality of output fibers is described. The system includes optical detectors which are connected to each of the input fibers for converting the optic data signals appearing at the respective input fibers to an RF signal. A plurality of RF to optical signal converters are arranged in rows and columns. The output of each of the optical detectors are each applied to a respective row of optical signal converted for being converters back to an optical signal when the particular optical signal converter is selectively activated by a dc voltage.
Micropower RF material proximity sensor
McEwan, Thomas E.
1998-01-01
A level detector or proximity detector for materials capable of sensing through plastic container walls or encapsulating materials is of the sensor. Thus, it can be used in corrosive environments, as well as in a wide variety of applications. An antenna has a characteristic impedance which depends on the materials in proximity to the antenna. An RF oscillator, which includes the antenna and is based on a single transistor in a Colpitt's configuration, produces an oscillating signal. A detector is coupled to the oscillator which signals changes in the oscillating signal caused by changes in the materials in proximity to the antenna. The oscillator is turned on and off at a pulse repetition frequency with a low duty cycle to conserve power. The antenna consists of a straight monopole about one-quarter wavelength long at the nominal frequency of the oscillator. The antenna may be horizontally disposed on a container and very accurately detects the fill level within the container as the material inside the container reaches the level of the antenna.
Micropower RF material proximity sensor
McEwan, T.E.
1998-11-10
A level detector or proximity detector for materials capable of sensing through plastic container walls or encapsulating materials is disclosed. Thus, it can be used in corrosive environments, as well as in a wide variety of applications. An antenna has a characteristic impedance which depends on the materials in proximity to the antenna. An RF oscillator, which includes the antenna and is based on a single transistor in a Colpitt`s configuration, produces an oscillating signal. A detector is coupled to the oscillator which signals changes in the oscillating signal caused by changes in the materials in proximity to the antenna. The oscillator is turned on and off at a pulse repetition frequency with a low duty cycle to conserve power. The antenna consists of a straight monopole about one-quarter wavelength long at the nominal frequency of the oscillator. The antenna may be horizontally disposed on a container and very accurately detects the fill level within the container as the material inside the container reaches the level of the antenna. 5 figs.
NASA Astrophysics Data System (ADS)
Ning, G.; Shum, P.
2007-06-01
We derive the expressions for the power fading including first-order polarization mode dispersion (PMD), chromatic dispersion, chirp parameter as well as polarization-dependent chromatic dispersion (PCD), which is dependent on the angle of precession of output state of polarization around the PMD vector. From the expression for radio frequency (RF) signals power fading, we get the average power fading for chromatic dispersion, chirp parameter, first-order PMD and PCD for both double sideband (DSB) modulation and single sideband (SSB) modulation. We also demonstrate a fast PMD and chromatic dispersion monitoring technology with reduced polarization-dependent gain. The measured results agree well with theoretical analysis.
Patterned optogenetic modulation of neurovascular and metabolic signals
Richner, Thomas J; Baumgartner, Ryan; Brodnick, Sarah K; Azimipour, Mehdi; Krugner-Higby, Lisa A; Eliceiri, Kevin W; Williams, Justin C; Pashaie, Ramin
2015-01-01
The hemodynamic and metabolic response of the cortex depends spatially and temporally on the activity of multiple cell types. Optogenetics enables specific cell types to be modulated with high temporal precision and is therefore an emerging method for studying neurovascular and neurometabolic coupling. Going beyond temporal investigations, we developed a microprojection system to apply spatial photostimulus patterns in vivo. We monitored vascular and metabolic fluorescence signals after photostimulation in Thy1-channelrhodopsin-2 mice. Cerebral arteries increased in diameter rapidly after photostimulation, while nearby veins showed a slower smaller response. The amplitude of the arterial response was depended on the area of cortex stimulated. The fluorescence signal emitted at 450/100 nm and excited with ultraviolet is indicative of reduced nicotinamide adenine dinucleotide, an endogenous fluorescent enzyme involved in glycolysis and the citric acid cycle. This fluorescence signal decreased quickly and transiently after optogenetic stimulation, suggesting that glucose metabolism is tightly locked to optogenetic stimulation. To verify optogenetic stimulation of the cortex, we used a transparent substrate microelectrode array to map cortical potentials resulting from optogenetic stimulation. Spatial optogenetic stimulation is a new tool for studying neurovascular and neurometabolic coupling. PMID:25388678
Alternative technological development for RF hybridization
NASA Astrophysics Data System (ADS)
Antônio Finardi, Célio; da Fontoura Ponchet, André; Battesini Adamo, Cristina; Flacker, Alexander; Cotrin Teixeira, Ricardo; Panepucci, Roberto Ricardo
2017-03-01
The paper presents a technological solution for high frequency packaging platform evaluated up to 40 GHz. The main purpose of this development was to define an alternative hybrid technology that is more flexible and faster to prototype compared with thin film or multi chip module (MCM-D). The alternative technology also shows adequate performance for high bit rate solutions integrating optical and electronics blocks. This approach consists of a soft substrate (laminate material), plating processes (electroless Ni-P/Au, electrolytic Au) and lithography patterning. Ground coplanar waveguide was used for microwave structures with excellent ground planes connections due to easy via holes implementation. We present results of high frequency packaging of important RF blocks, such as integrated broadband bias-T, transimpedance amplifier ICs and silicon photonics optical modulators. The paper demonstrates a solution for high frequency hybridization that can be implemented with standard substrates, designed with any shape and with large numbers of metalized via holes and compatible with usual assembling techniques.
High-frequency modulated signals of killer whales (Orcinus orca) in the North Pacific.
Simonis, Anne E; Baumann-Pickering, Simone; Oleson, Erin; Melcón, Mariana L; Gassmann, Martin; Wiggins, Sean M; Hildebrand, John A
2012-04-01
Killer whales in the North Pacific, similar to Atlantic populations, produce high-frequency modulated signals, based on acoustic recordings from ship-based hydrophone arrays and autonomous recorders at multiple locations. The median peak frequency of these signals ranged from 19.6-36.1 kHz and median duration ranged from 50-163 ms. Source levels were 185-193 dB peak-to-peak re: 1 μPa at 1 m. These uniform, repetitive, down-swept signals are similar to bat echolocation signals and possibly could have echolocation functionality. A large geographic range of occurrence suggests that different killer whale ecotypes may utilize these signals.
Optimal space communications techniques. [discussion of video signals and delta modulation
NASA Technical Reports Server (NTRS)
Schilling, D. L.
1974-01-01
The encoding of video signals using the Song Adaptive Delta Modulator (Song ADM) is discussed. The video signals are characterized as a sequence of pulses having arbitrary height and width. Although the ADM is suited to tracking signals having fast rise times, it was found that the DM algorithm (which permits an exponential rise for estimating an input step) results in a large overshoot and an underdamped response to the step. An overshoot suppression algorithm which significantly reduces the ringing while not affecting the rise time is presented along with formuli for the rise time and the settling time. Channel errors and their effect on the DM encoded bit stream were investigated.
NASA Astrophysics Data System (ADS)
Bleuel, M.; Bröll, M.; Lang, E.; Littrell, K.; Gähler, R.; Lal, J.
2006-01-01
In this paper we report the results of our first tests of a novel proof-of-principle instrument developed at the IPNS, Argonne. The experiment was performed on the time of flight POSY1 instrument, the polarized reflectometer at the IPNS, which was modified to accommodate the apparatus. Two sets of RF-flippers were tested together, generating a modulated intensity by zero effort (MIEZE)-type neutron resonant spin echo signal which was observed at the detector using a wide neutron wavelength band.
Modulating Retro-Reflectors: Technology, Link Budgets and Applications
NASA Technical Reports Server (NTRS)
Salas, Alberto Guillen; Stupl, Jan; Mason, James
2012-01-01
Satellite communications systems today -- usually radio frequency (RF) -- tend to have low data rates and use a lot of on-board power. For CubeSats, communications often dominate the power budget. We investigate the use of modulating retro-reflectors (MRRs), previously demonstrated on the ground, for high data-rate communication downlinks from small satellites. A laser ground station would illuminate a retro-reflector on-board the satellite while an element in the retro-reflector modulates the intensity of the reflected signal, thereby encoding a data stream on the returning beam. A detector on the ground receives the data, keeping the complex systems and the vast majority of power consumption on the ground. Reducing the power consumption while increasing data rates would relax constraints on power budgets for small satellites, leaving more power available for payloads. In the future, this could enable the use of constellations of nano-satellites for a variety of missions, possibly leading to a paradigm shift in small satellite applications.
Negative ion source with external RF antenna
Leung, Ka-Ngo; Hahto, Sami K.; Hahto, Sari T.
2007-02-13
A radio frequency (RF) driven plasma ion source has an external RF antenna, i.e. the RF antenna is positioned outside the plasma generating chamber rather than inside. The RF antenna is typically formed of a small diameter metal tube coated with an insulator. An external RF antenna assembly is used to mount the external RF antenna to the ion source. The RF antenna tubing is wound around the external RF antenna assembly to form a coil. The external RF antenna assembly is formed of a material, e.g. quartz, which is essentially transparent to the RF waves. The external RF antenna assembly is attached to and forms a part of the plasma source chamber so that the RF waves emitted by the RF antenna enter into the inside of the plasma chamber and ionize a gas contained therein. The plasma ion source is typically a multi-cusp ion source. A converter can be included in the ion source to produce negative ions.
Small-tip fast recovery imaging using non-slice-selective tailored tip-up pulses and RF-spoiling
Nielsen, Jon-Fredrik; Yoon, Daehyun; Noll, Douglas C.
2012-01-01
Small-tip fast recovery (STFR) imaging is a new steady-state imaging sequence that is a potential alternative to balanced steady-state free precession (bSSFP). Under ideal imaging conditions, STFR may provide comparable signal-to-noise ratio (SNR) and image contrast as bSSFP, but without signal variations due to resonance offset. STFR relies on a tailored “tip-up”, or “fast recovery”, RF pulse to align the spins with the longitudinal axis after each data readout segment. The design of the tip-up pulse is based on the acquisition of a separate off-resonance (B0) map. Unfortunately, the design of fast (a few ms) slice- or slab-selective RF pulses that accurately tailor the excitation pattern to the local B0 inhomogeneity over the entire imaging volume remains a challenging and unsolved problem. We introduce a novel implementation of STFR imaging based on non-slice-selective tip-up pulses, which simplifies the RF design problem significantly. Out-of-slice magnetization pathways are suppressed using RF-spoiling. Brain images obtained with this technique show excellent gray/white matter contrast, and point to the possibility of rapid steady-state T2/T1-weighted imaging with intrinsic suppression of cerebrospinal fluid, through-plane vessel signal, and off-resonance artifacts. In the future we expect STFR imaging to benefit significantly from parallel excitation hardware and high-order gradient shim systems. PMID:22511367
Noninvasive Fetal Electrocardiography Part II: Segmented-Beat Modulation Method for Signal Denoising
Agostinelli, Angela; Sbrollini, Agnese; Burattini, Luca; Fioretti, Sandro; Di Nardo, Francesco; Burattini, Laura
2017-01-01
Background: Fetal well-being evaluation may be accomplished by monitoring cardiac activity through fetal electrocardiography. Direct fetal electrocardiography (acquired through scalp electrodes) is the gold standard but its invasiveness limits its clinical applicability. Instead, clinical use of indirect fetal electrocardiography (acquired through abdominal electrodes) is limited by its poor signal quality. Objective: Aim of this study was to evaluate the suitability of the Segmented-Beat Modulation Method to denoise indirect fetal electrocardiograms in order to achieve a signal-quality at least comparable to the direct ones. Method: Direct and indirect recordings, simultaneously acquired from 5 pregnant women during labor, were filtered with the Segmented-Beat Modulation Method and correlated in order to assess their morphological correspondence. Signal-to-noise ratio was used to quantify their quality. Results: Amplitude was higher in direct than indirect fetal electrocardiograms (median:104 µV vs. 22 µV; P=7.66·10-4), whereas noise was comparable (median:70 µV vs. 49 µV, P=0.45). Moreover, fetal electrocardiogram amplitude was significantly higher than affecting noise in direct recording (P=3.17·10-2) and significantly in indirect recording (P=1.90·10-3). Consequently, signal-to-noise ratio was initially higher for direct than indirect recordings (median:3.3 dB vs. -2.3 dB; P=3.90·10-3), but became lower after denoising of indirect ones (median:9.6 dB; P=9.84·10-4). Eventually, direct and indirect recordings were highly correlated (median: ρ=0.78; P<10-208), indicating that the two electrocardiograms were morphologically equivalent. Conclusion: Segmented-Beat Modulation Method is particularly useful for denoising of indirect fetal electrocardiogram and may contribute to the spread of this noninvasive technique in the clinical practice. PMID:28567129
NASA Astrophysics Data System (ADS)
Pekar, Martin; van der Mark, Martin B.
2017-02-01
Smart medical catheters face a connectivity challenge. An example is found in ultrasound imaging where the supply of power at the distal end and the signal transmission requires many thin and fragile wires in order to keep the catheter thin and flexible and this leads to a relatively high cost of production. We have built a fully functional benchtop demonstrator that is immediately scalable to catheter dimensions, in which all electrical wires are replaced by just two optical fibers. We show signal transfer of synthetic aperture ultrasound images as well as photovoltaic conversion to supply all electronics. The absence of conductors provides excellent galvanic isolation as well as RF and MRI compatibility and the simple design utilizing off the shelf components holds a promise of cost effectiveness all of which may help translation of these advanced devices into the clinic. We show photovoltaic conversion of 405 nm light to 45 V and 1.8 V by two blue LEDs as well as 200 MHz broad-band signal transfer using modulated 850 nm VCSEL light. Synthetic aperture ultrasound images are acquired at a frequency of 12 MHz with a collapse-mode capacitive-micromachined ultrasonic transducer. Bandwidth, noise level and dynamic range are nearly identical as shown in comparison of the images acquired with the optical link and its electrical equivalent. In conclusion, we have successfully demonstrated low-cost and scalable optical signal and power transmission for an ultrasound imaging system enjoying intrinsic RF / MRI compatibility and galvanic isolation.
NASA Astrophysics Data System (ADS)
Feng, Zhipeng; Chu, Fulei; Zuo, Ming J.
2011-03-01
Energy separation algorithm is good at tracking instantaneous changes in frequency and amplitude of modulated signals, but it is subject to the constraints of mono-component and narrow band. In most cases, time-varying modulated vibration signals of machinery consist of multiple components, and have so complicated instantaneous frequency trajectories on time-frequency plane that they overlap in frequency domain. For such signals, conventional filters fail to obtain mono-components of narrow band, and their rectangular decomposition of time-frequency plane may split instantaneous frequency trajectories thus resulting in information loss. Regarding the advantage of generalized demodulation method in decomposing multi-component signals into mono-components, an iterative generalized demodulation method is used as a preprocessing tool to separate signals into mono-components, so as to satisfy the requirements by energy separation algorithm. By this improvement, energy separation algorithm can be generalized to a broad range of signals, as long as the instantaneous frequency trajectories of signal components do not intersect on time-frequency plane. Due to the good adaptability of energy separation algorithm to instantaneous changes in signals and the mono-component decomposition nature of generalized demodulation, the derived time-frequency energy distribution has fine resolution and is free from cross term interferences. The good performance of the proposed time-frequency analysis is illustrated by analyses of a simulated signal and the on-site recorded nonstationary vibration signal of a hydroturbine rotor during a shut-down transient process, showing that it has potential to analyze time-varying modulated signals of multi-components.
Burns, Justin L; Jariwala, Parth B; Rivera, Shannon; Fontaine, Benjamin M; Briggs, Laura; Weinert, Emily E
2017-08-18
Bacterial pathogens utilize numerous signals to identify the presence of their host and coordinate changes in gene expression that allow for infection. Within plant pathogens, these signals typically include small molecules and/or proteins from their plant hosts and bacterial quorum sensing molecules to ensure sufficient bacterial cell density for successful infection. In addition, bacteria use environmental signals to identify conditions when the host defenses are weakened and potentially to signal entry into an appropriate host/niche for infection. A globin coupled sensor protein (GCS), termed PccGCS, within the soft rot bacterium Pectobacterium carotovorum ssp. carotovorum WPP14 has been identified as an O 2 sensor and demonstrated to alter virulence factor excretion and control motility, with deletion of PccGCS resulting in decreased rotting of a potato host. Using small molecules that modulate bacterial growth and quorum sensing, PccGCS signaling also has been shown to modulate quorum sensing pathways, resulting in the PccGCS deletion strain being more sensitive to plant-derived phenolic acids, which can function as quorum sensing inhibitors, and exhibiting increased N-acylhomoserine lactone (AHL) production. These findings highlight a role for GCS proteins in controlling key O 2 -dependent phenotypes of pathogenic bacteria and suggest that modulating GCS signaling to limit P. carotovorum motility may provide a means to decrease rotting of plant hosts.
Measurement of RF propagation around corners in underground mines and tunnels.
Jacksha, R; Zhou, C
2016-01-01
This paper reports measurement results for radio frequency (RF) propagation around 90° corners in tunnels and underground mines, for vertically, horizontally and longitudinally polarized signals. Measurements of signal power attenuation from a main entry into a crosscut were performed at four frequencies - 455, 915, 2450 and 5800 MHz - that are common to underground radio communication systems. From the measurement data, signal power loss was determined as a function of signal coupling from the main entry into the crosscut. The resultant power loss data show there are many factors that contribute to power attenuation from a main entry into a crosscut, including frequency, antenna polarization and cross-sectional entry dimensions.
Radio-frequency-modulated Rydberg states in a vapor cell
NASA Astrophysics Data System (ADS)
Miller, S. A.; Anderson, D. A.; Raithel, G.
2016-05-01
We measure strong radio-frequency (RF) electric fields using rubidium Rydberg atoms prepared in a room-temperature vapor cell as field sensors. Electromagnetically induced transparency is employed as an optical readout. We RF-modulate the 60{{{S}}}1/2 and 58{{{D}}}5/2 Rydberg states with 50 and 100 MHz fields, respectively. For weak to moderate RF fields, the Rydberg levels become Stark-shifted, and sidebands appear at even multiples of the driving frequency. In high fields, the adjacent hydrogenic manifold begins to intersect the shifted levels, providing rich spectroscopic structure suitable for precision field measurements. A quantitative description of strong-field level modulation and mixing of S and D states with hydrogenic states is provided by Floquet theory. Additionally, we estimate the shielding of DC electric fields in the interior of the glass vapor cell.
Shen, H; Zhao, S H; Cao, J H; Li, X Y; Fan, B
2011-11-01
Muscle specific RING finger protein2 (MuRF2) and Muscle specific RING finger protein3(MuRF3) are two important members of the muscle specific RING finger protein family, which are especially expressed in cardiac and skeletal muscle tissues and play critical roles during the myocyte differentiation, development and morphogenesis. In this study, the molecular characteristics of porcine MuRF2 and MuRF3 gene were reported, and furthermore two variants of MuRF2 were identified. The tissue distribution pattern analyses revealed that MuRF2-b and MuRF3 mRNA was exclusively expressed in striated muscle tissues while MuRF2-a had a low-level expression in liver tissue. Real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) results displayed MuRF2 mRNA expression levels were significantly varied at three stages of fetal skeletal muscle in Landrace pigs, and the expression of MuRF2-a was lower than that of MuRF2-b in all stages. An essencial region of -396 to -22 for transcription was identified at the 5'UTR of porcine MuRF2 gene, while no active regulatory fragment found in the 5'UTR of mouse MuRF2. A single nucleotide polymorphism (SNP), c.915G > A was identified in MuRF2 exon 5. A HinfI PCR-RFLP was developed for SNP genotyping in two different pig populations. Association of the genotypes with growth and carcass traits showed that different genotypes of MuRF2 were significantly (P < 0.05) associated with average daily gain on test, carcass weight and carcass length. The study suggested that the porcine MuRF2 and MuRF3 genes are involved in the muscle growth and development, and can be considered as potential candidate genes affecting muscle production traits in the pig.
Fabrication and RF characterization of zinc oxide based Film Bulk Acoustic Resonator
NASA Astrophysics Data System (ADS)
Patel, Raju; Bansal, Deepak; Agrawal, Vimal Kumar; Rangra, Kamaljit; Boolchandani, Dharmendar
2018-06-01
This work reports fabrication and characterization of Film Bulk Acoustic Resonator (FBAR) to improve the performance characteristics for RF filter and sensing application. Zinc oxide as a piezoelectric (PZE) material was deposited on an aluminum bottom electrode using an RF magnetron sputtering, at room temperature, and gold as top electrode for the resonator. Tetramethyl ammonium hydroxide (TMAH) setup was used for bulk silicon etching to make back side cavity to confine the acoustic signals. The transmission characteristics show that the FBARs have a central frequency at 1.77 GHz with a return loss of -10.7 dB.
Transmission analysis for OFDM signals over hybrid RF-optical high-throughput satellite.
Kolev, Dimitar R; Toyoshima, Morio
2018-02-19
In this paper, a theoretical investigation of the performance of a communication scenario where a geostationary-orbit satellite provides radio-frequency broadband access to the users through orthogonal-frequency-division multiplexing technology and has an optical feeder link is presented. The interface between the radio frequency and the optical parts is achieved by using radio-on-fiber technology for optical-electro and electro-optical conversion onboard and no further signal processing is required. The proposed scheme has significant potential, but presents limitations related to the noise. The noise in both forward and reverse links is described, and the system performance for an example scenario with 1280 MHz bandwidth for QPSK, 16QAM, and 64QAM subcarrier modulation is estimated. The obtained results show that under certain conditions regarding link budget and components choice, the proposed solution is feasible.
NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer.
Wallez, Yann; Mace, Peter D; Pasquale, Elena B; Riedl, Stefan J
2012-05-01
The CAS (CRK-associated substrate) family of adaptor proteins comprises 4 members, which share a conserved modular domain structure that enables multiple protein-protein interactions, leading to the assembly of intracellular signaling platforms. Besides their physiological role in signal transduction downstream of a variety of cell surface receptors, CAS proteins are also critical for oncogenic transformation and cancer cell malignancy through associations with a variety of regulatory proteins and downstream effectors. Among the regulatory partners, the 3 recently identified adaptor proteins constituting the NSP (novel SH2-containing protein) family avidly bind to the conserved carboxy-terminal focal adhesion-targeting (FAT) domain of CAS proteins. NSP proteins use an anomalous nucleotide exchange factor domain that lacks catalytic activity to form NSP-CAS signaling modules. Additionally, the NSP SH2 domain can link NSP-CAS signaling assemblies to tyrosine-phosphorylated cell surface receptors. NSP proteins can potentiate CAS function by affecting key CAS attributes such as expression levels, phosphorylation state, and subcellular localization, leading to effects on cell adhesion, migration, and invasion as well as cell growth. The consequences of these activities are well exemplified by the role that members of both families play in promoting breast cancer cell invasiveness and resistance to antiestrogens. In this review, we discuss the intriguing interplay between the NSP and CAS families, with a particular focus on cancer signaling networks.
NASA Technical Reports Server (NTRS)
Levine, D. M.
1978-01-01
Radiation from lightning in the RF band from 3-300 MHz were monitored. Radiation in this frequency range is of interest as a potential vehicle for monitoring severe storms and for studying the lightning itself. Simultaneous measurements were made of RF radiation and fast and slow field changes. Continuous analogue recordings with a system having 300 kHz of bandwidth were made together with digital records of selected events (principally return strokes) at greater temporal resolution. The data reveal patterns in the RF radiation for the entire flash which are characteristic of flash type and independent of the frequency of observation. Individual events within the flash also have characteristic RF patterns. Strong radiation occurs during the first return strokes, but delayed about 20 micron sec with respect to the begining of the return stroke; whereas, RF radiation from subsequent return strokes tends to be associated with cloud processes preceding the flash with comparatively little radiation occurring during the return stroke itself.
Hierarchical Feedback Modules and Reaction Hubs in Cell Signaling Networks
Xu, Jianfeng; Lan, Yueheng
2015-01-01
Despite much effort, identification of modular structures and study of their organizing and functional roles remain a formidable challenge in molecular systems biology, which, however, is essential in reaching a systematic understanding of large-scale cell regulation networks and hence gaining capacity of exerting effective interference to cell activity. Combining graph theoretic methods with available dynamics information, we successfully retrieved multiple feedback modules of three important signaling networks. These feedbacks are structurally arranged in a hierarchical way and dynamically produce layered temporal profiles of output signals. We found that global and local feedbacks act in very different ways and on distinct features of the information flow conveyed by signal transduction but work highly coordinately to implement specific biological functions. The redundancy embodied with multiple signal-relaying channels and feedback controls bestow great robustness and the reaction hubs seated at junctions of different paths announce their paramount importance through exquisite parameter management. The current investigation reveals intriguing general features of the organization of cell signaling networks and their relevance to biological function, which may find interesting applications in analysis, design and control of bio-networks. PMID:25951347
Signal acquisition module design for multi-channel surface magnetic resonance sounding system
NASA Astrophysics Data System (ADS)
Lin, Tingting; Chen, Wuqiang; Du, Wenyuan; Zhao, Jing
2015-11-01
To obtain a precise 2D/3D image of fissure or karst water, multi-channel magnetic resonance sounding (MRS) systems using edge-to-edge or overlapping receiving coils are needed. Thus, acquiring a nano-volt signal for a small amount of the aquifer and suppressing the mutual coupling between adjacent coils are two important issues for the design of the signal acquisition module in the system. In the present study, we propose to use a passive low pass filter, consisted of a resistance (R) and capacitance (C), to inhibit the mutual coupling effects of the coils. Four low-noise operational amplifiers LT1028, OPA124, AD745, and OP27 were compared with respect to achieving the lowest system noise. As a result, 3 pieces of LT1028 were chosen and connected in parallel to serve as preamplifier, with a sensitivity of 1.4 nV/√Hz at 2 kHz. Experimental results are presented for 2D MRS groundwater investigations conducted in the suburb of Changchun, China. The inversion result is consistent with the result of drilling log, suggesting that the signal acquisition module is well developed.
XUV pulse effect on signal modulations of harmonic spectra from H2+ and T2+
NASA Astrophysics Data System (ADS)
Feng, Liqiang; Liu, Hang; Kapteyn, Henry J.; Feng, April Y.
2018-05-01
The effects of signal modulations on the molecular high-order harmonic generations in H2^{+ } and T2+ have been theoretically investigated. It is found that with the introduction of the XUV pulse, due to the absorption of the extra XUV photons in the recombination process, multiplateaus on the harmonic spectra, separated by the XUV photon energy can be found. Moreover, this multiplateau structure is insensitive to the wavelength of the XUV pulse. In shorter pulse duration, the intensities of the multiplateaus from H2+ are higher than those from T2+; while in longer pulse duration, the opposite results can be found. Finally, by changing the delay time of the XUV pulse, the signal modulations (including the amplitude and the frequency modulations) of the multiplateaus can be controlled.
A low-level rf control system for a quarter-wave resonator
NASA Astrophysics Data System (ADS)
Kim, Jongwon; Hwang, Churlkew
2012-06-01
A low-level rf control system was designed and built for an rf deflector, which is a quarter wave resonator, and was designed to deflect a secondary electron beam to measure the bunch length of an ion beam. The deflector has a resonance frequency near 88 MHz, its required phase stability is approximately ±1° and its amplitude stability is less than ±1%. The control system consists of analog input and output components and a digital system based on a field-programmable gate array for signal processing. The system is cost effective, while meeting the stability requirements. Some basic properties of the control system were measured. Then, the capability of the rf control was tested using a mechanical vibrator made of a dielectric rod attached to an audio speaker system, which could induce regulated perturbations in the electric fields of the resonator. The control system was flexible so that its parameters could be easily configured to compensate for the disturbance induced in the resonator.
Acousto-optic modulation and opto-acoustic gating in piezo-optomechanical circuits
Balram, Krishna C.; Davanço, Marcelo I.; Ilic, B. Robert; Kyhm, Ji-Hoon; Song, Jin Dong; Srinivasan, Kartik
2017-01-01
Acoustic wave devices provide a promising chip-scale platform for efficiently coupling radio frequency (RF) and optical fields. Here, we use an integrated piezo-optomechanical circuit platform that exploits both the piezoelectric and photoelastic coupling mechanisms to link 2.4 GHz RF waves to 194 THz (1550 nm) optical waves, through coupling to propagating and localized 2.4 GHz acoustic waves. We demonstrate acousto-optic modulation, resonant in both the optical and mechanical domains, in which waveforms encoded on the RF carrier are mapped to the optical field. We also show opto-acoustic gating, in which the application of modulated optical pulses interferometrically gates the transmission of propagating acoustic pulses. The time-domain characteristics of this system under both pulsed RF and pulsed optical excitation are considered in the context of the different physical pathways involved in driving the acoustic waves, and modelled through the coupled mode equations of cavity optomechanics. PMID:28580373
Use of a compact range approach to evaluate rf and dual-mode missiles
NASA Astrophysics Data System (ADS)
Willis, Kenneth E.; Weiss, Yosef
2000-07-01
This paper describes a hardware-in-the-loop (HWIL) system developed for testing Radio Frequency (RF), Infra-Red (IR), and Dual-Mode missile seekers. The system consists of a unique hydraulic five-axis (three seeker axes plus two target axes) Flight Motion Table (FMT), an off-axis parabolic reflector, and electronics required to generate the signals to the RF feeds. RF energy that simulates the target is fed into the reflector from three orthogonal feeds mounted on the inner target axis, at the focal point area of the parabolic reflector. The parabolic reflector, together with the three RF feeds (the Compact Range), effectively produces a far-field image of the target. Both FMT target axis motion and electronic control of the RF beams (deflection) modify the simulated line-of-sight target angles. Multiple targets, glint, multi-path, ECM, and clutter can be introduced electronically. To evaluate dual-mode seekers, the center section of the parabolic reflector is replaced with an IR- transparent, but RF-reflective section. An IR scene projector mounts to the FMT target axes, with its image focused on the intersection of the FMT seeker axes. The system eliminates the need for a large anechoic chamber and 'Target Wall' or target motion system used with conventional HWIL systems. This reduces acquisition and operating costs of the facility.
500 MHz narrowband beam position monitor electronics for electron synchrotrons
NASA Astrophysics Data System (ADS)
Mohos, I.; Dietrich, J.
1998-12-01
Narrowband beam position monitor electronics were developed in the Forschungszentrum Jülich-IKP for the orbit measurement equipment used at ELSA Bonn. The equipment uses 32 monitor chambers, each with four capacitive button electrodes. The monitor electronics, consisting of an rf signal processing module (BPM-RF) and a data acquisition and control module (BPM-DAQ), sequentially process and measure the monitor signals and deliver calculated horizontal and vertical beam position data via a serial network.
Advanced Digital Signal Processing for Hybrid Lidar
2014-10-30
obtain range measurements . A MATLAB- based system developed at Clarkson University in FY14 has been used to perform real-time FDR ranging... measurement accuracy. There have been various methods that attempt to reduce the backscatter. One method is to increase the modulation frequency beyond...an unambiguous range measurement . In general, it is desired to determine which combination of Radio Frequency (RF) modulation frequencies, modulation
Yoder, Kathleen M.; Vicario, David S.
2012-01-01
Gonadal hormones modulate behavioral responses to sexual stimuli, and communication signals can also modulate circulating hormone levels. In several species, these combined effects appear to underlie a two-way interaction between circulating gonadal hormones and behavioral responses to socially salient stimuli. Recent work in songbirds has shown that manipulating local estradiol levels in the auditory forebrain produces physiological changes that affect discrimination of conspecific vocalizations and can affect behavior. These studies provide new evidence that estrogens can directly alter auditory processing and indirectly alter the behavioral response to a stimulus. These studies show that: 1. Local estradiol action within an auditory area is necessary for socially-relevant sounds to induce normal physiological responses in the brains of both sexes; 2. These physiological effects occur much more quickly than predicted by the classical time-frame for genomic effects; 3. Estradiol action within the auditory forebrain enables behavioral discrimination among socially-relevant sounds in males; and 4. Estradiol is produced locally in the male brain during exposure to particular social interactions. The accumulating evidence suggests a socio-neuro-endocrinology framework in which estradiol is essential to auditory processing, is increased by a socially relevant stimulus, acts rapidly to shape perception of subsequent stimuli experienced during social interactions, and modulates behavioral responses to these stimuli. Brain estrogens are likely to function similarly in both songbird sexes because aromatase and estrogen receptors are present in both male and female forebrain. Estrogenic modulation of perception in songbirds and perhaps other animals could fine-tune male advertising signals and female ability to discriminate them, facilitating mate selection by modulating behaviors. Keywords: Estrogens, Songbird, Social Context, Auditory Perception PMID:22201281
Suitability of miniature inductively coupled RF coils as MR-visible markers for clinical purposes.
Garnov, Nikita; Thormer, Gregor; Trampel, Robert; Grunder, Wilfried; Kahn, Thomas; Moche, Michael; Busse, Harald
2011-11-01
MR-visible markers have already been used for various purposes such as image registration, motion detection, and device tracking. Inductively coupled RF (ICRF) coils, in particular, provide a high contrast and do not require connecting wires to the scanner, which makes their application highly flexible and safe. This work aims to thoroughly characterize the MR signals of such ICRF markers under various conditions with a special emphasis on fully automatic detection. The small markers consisted of a solenoid coil that was wound around a glass tube containing the MR signal source and tuned to the resonance frequency of a 1.5 T MRI. Marker imaging was performed with a spoiled gradient echo sequence (FLASH) and a balanced steady-state free precession (SSFP) sequence (TrueFISP) in three standard projections. The signal intensities of the markers were recorded for both pulse sequences, three source materials (tap water, distilled water, and contrast agent solution), different flip angles and coil alignments with respect to the B(0) direction as well as for different marker positions in the entire imaging volume (field of view, FOV). Heating of the ICRF coils was measured during 10-min RF expositions to three conventional pulse sequences. Clinical utility of the markers was assessed from their performance in computer-aided detection and in defining double oblique scan planes. For almost the entire FOV (±215 mm) and an estimated 82% of all possible RF coil alignments with respect to B(0), the ICRF markers generated clearly visible MR signals and could be reliably localized over a large range of flip angles, in particular with the TrueFISP sequence (0.3°-4.0°). Generally, TrueFISP provided a higher marker contrast than FLASH. RF exposition caused a moderate heating (≤5 °C) of the ICRF coils only. Small ICRF coils, imaged at low flip angles with a balanced SSFP sequence showed an excellent performance under a variety of experimental conditions and therefore make for a
NASA Astrophysics Data System (ADS)
Bai, Guang-Fu; Hu, Lin; Jiang, Yang; Tian, Jing; Zi, Yue-Jiao; Wu, Ting-Wei; Huang, Feng-Qin
2017-08-01
In this paper, a photonic microwave waveform generator based on a dual-parallel Mach-Zehnder modulator is proposed and experimentally demonstrated. In this reported scheme, only one radio frequency signal is used to drive the dual-parallel Mach-Zehnder modulator. Meanwhile, dispersive elements or filters are not required in the proposed scheme, which make the scheme simpler and more stable. In this way, six variables can be adjusted. Through the different combinations of these variables, basic waveforms with full duty and small duty cycle can be generated. Tunability of the generator can be achieved by adjusting the frequency of the RF signal and the optical carrier. The corresponding theoretical analysis and simulation have been conducted. With guidance of theory and simulation, proof-of-concept experiments are carried out. The basic waveforms, including Gaussian, saw-up, and saw-down waveforms, with full duty and small duty cycle are generated at the repetition rate of 2 GHz. The theoretical and simulation results agree with the experimental results very well.
Aida, Kazuo; Sugie, Toshihiko
2011-12-12
We propose a method of testing transmission fiber lines and distributed amplifiers. Multipath interference (MPI) is detected as a beat spectrum between a multipath signal and a direct signal using a synthesized chirped test signal with lightwave frequencies of f(1) and f(2) periodically emitted from a distributed feedback laser diode (DFB-LD). This chirped test pulse is generated using a directly modulated DFB-LD with a drive signal calculated using a digital signal processing technique (DSP). A receiver consisting of a photodiode and an electrical spectrum analyzer (ESA) detects a baseband power spectrum peak appearing at the frequency of the test signal frequency deviation (f(1)-f(2)) as a beat spectrum of self-heterodyne detection. Multipath interference is converted from the spectrum peak power. This method improved the minimum detectable MPI to as low as -78 dB. We discuss the detailed design and performance of the proposed test method, including a DFB-LD drive signal calculation algorithm with DSP for synthesis of the chirped test signal and experiments on single-mode fibers with discrete reflections. © 2011 Optical Society of America
Algorithm for the classification of multi-modulating signals on the electrocardiogram.
Mita, Mitsuo
2007-03-01
This article discusses the algorithm to measure electrocardiogram (ECG) and respiration simultaneously and to have the diagnostic potentiality for sleep apnoea from ECG recordings. The algorithm is composed by the combination with the three particular scale transform of a(j)(t), u(j)(t), o(j)(a(j)) and the statistical Fourier transform (SFT). Time and magnitude scale transforms of a(j)(t), u(j)(t) change the source into the periodic signal and tau(j) = o(j)(a(j)) confines its harmonics into a few instantaneous components at tau(j) being a common instant on two scales between t and tau(j). As a result, the multi-modulating source is decomposed by the SFT and is reconstructed into ECG, respiration and the other signals by inverse transform. The algorithm is expected to get the partial ventilation and the heart rate variability from scale transforms among a(j)(t), a(j+1)(t) and u(j+1)(t) joining with each modulation. The algorithm has a high potentiality of the clinical checkup for the diagnosis of sleep apnoea from ECG recordings.
Lightweight Biometric Sensing for Walker Classification Using Narrowband RF Links
Liang, Zhuo-qian
2017-01-01
This article proposes a lightweight biometric sensing system using ubiquitous narrowband radio frequency (RF) links for path-dependent walker classification. The fluctuated received signal strength (RSS) sequence generated by human motion is used for feature representation. To capture the most discriminative characteristics of individuals, a three-layer RF sensing network is organized for building multiple sampling links at the most common heights of upper limbs, thighs, and lower legs. The optimal parameters of sensing configuration, such as the height of link location and number of fused links, are investigated to improve sensory data distinctions among subjects, and the experimental results suggest that the synergistic sensing by using multiple links can contribute a better performance. This is the new consideration of using RF links in building a biometric sensing system. In addition, two types of classification methods involving vector quantization (VQ) and hidden Markov models (HMMs) are developed and compared for closed-set walker recognition and verification. Experimental studies in indoor line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios are conducted to validate the proposed method. PMID:29206188
Lightweight Biometric Sensing for Walker Classification Using Narrowband RF Links.
Liu, Tong; Liang, Zhuo-Qian
2017-12-05
This article proposes a lightweight biometric sensing system using ubiquitous narrowband radio frequency (RF) links for path-dependent walker classification. The fluctuated received signal strength (RSS) sequence generated by human motion is used for feature representation. To capture the most discriminative characteristics of individuals, a three-layer RF sensing network is organized for building multiple sampling links at the most common heights of upper limbs, thighs, and lower legs. The optimal parameters of sensing configuration, such as the height of link location and number of fused links, are investigated to improve sensory data distinctions among subjects, and the experimental results suggest that the synergistic sensing by using multiple links can contribute a better performance. This is the new consideration of using RF links in building a biometric sensing system. In addition, two types of classification methods involving vector quantization (VQ) and hidden Markov models (HMMs) are developed and compared for closed-set walker recognition and verification. Experimental studies in indoor line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios are conducted to validate the proposed method.
Spin transfer driven resonant expulsion of a magnetic vortex core for efficient rf detector
NASA Astrophysics Data System (ADS)
Menshawy, S.; Jenkins, A. S.; Merazzo, K. J.; Vila, L.; Ferreira, R.; Cyrille, M.-C.; Ebels, U.; Bortolotti, P.; Kermorvant, J.; Cros, V.
2017-05-01
Spin transfer magnetization dynamics have led to considerable advances in Spintronics, including opportunities for new nanoscale radiofrequency devices. Among the new functionalities is the radiofrequency (rf) detection using the spin diode rectification effect in spin torque nano-oscillators (STNOs). In this study, we focus on a new phenomenon, the resonant expulsion of a magnetic vortex in STNOs. This effect is observed when the excitation vortex radius, due to spin torques associated to rf currents, becomes larger than the actual radius of the STNO. This vortex expulsion is leading to a sharp variation of the voltage at the resonant frequency. Here we show that the detected frequency can be tuned by different parameters; furthermore, a simultaneous detection of different rf signals can be achieved by real time measurements with several STNOs having different diameters. This result constitutes a first proof-of-principle towards the development of a new kind of nanoscale rf threshold detector.
Nakagata, Naomi; Miyagawa, Shinichi; Suzuki, Kentaro; Kitazawa, Sohei; Yamada, Gen
2012-01-01
Background Congenital diseases of the urinary tract are frequently observed in infants. Such diseases present a number of developmental anomalies such as hydroureter and hydronephrosis. Although some genetically-modified mouse models of growth factor signaling genes reproduce urinary phenotypes, the pathogenic mechanisms remain obscure. Previous studies suggest that a portion of the cells in the external genitalia and bladder are derived from peri-cloacal mesenchymal cells that receive Hedgehog (Hh) signaling in the early developmental stages. We hypothesized that defects in such progenitor cells, which give rise to urinary tract tissues, may be a cause of such diseases. Methodology/Principal Findings To elucidate the pathogenic mechanisms of upper urinary tract malformations, we analyzed a series of Sonic hedgehog (Shh) deficient mice. Shh−/− displayed hydroureter and hydronephrosis phenotypes and reduced expression of several developmental markers. In addition, we suggested that Shh modulation at an early embryonic stage is responsible for such phenotypes by analyzing the Shh conditional mutants. Tissue contribution assays of Hh-responsive cells revealed that peri-cloacal mesenchymal cells, which received Hh signal secreted from cloacal epithelium, could contribute to the ureteral mesenchyme. Gain- and loss-of-functional mutants for Hh signaling revealed a correlation between Hh signaling and Bone morphogenetic protein (Bmp) signaling. Finally, a conditional ablation of Bmp receptor type IA (BmprIA) gene was examined in Hh-responsive cell lineages. This system thus made it possible to analyze the primary functions of the growth factor signaling relay. The defective Hh-to-Bmp signaling relay resulted in severe urinary tract phenotypes with a decrease in the number of Hh-responsive cells. Conclusions/Significance This study identified the essential embryonic stages for the pathogenesis of urinary tract phenotypes. These results suggested that Hh
Modulation of Radio Frequency Signals by Nonlinearly Generated Acoustic Fields
2014-01-01
roll -off in attenuation, known as the filter skirt. Therefore, the use of filters can be inadequate if the small signals are close in frequency to the...effect can be avoided by introducing filters into the nonlinear measurement system that have much smaller bandwidths, capable of isolating narrow...contribution from each source of modulation has not been done as isolating each effect during measurement is currently infeasible. To better
Low Rate Transmission of Video Signals Using Adaptive Delta Modulation.
1983-08-15
903-80-C-0476 / . PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK AREA & WORK UNIT NUMBERS Research Foundation of CUNY on...transmitted phase, for the demodulation of the signal. AM is presently being used to transmit multilevel * symbols by vestigial or single sideband...34: Vestigial Sideband -- Duobinary 3600 4-Phase + AM 4800" 4-Phase + AM * Vestigial Sideband 8-PSK 7200 Phase and Amplitude Modulation 9600 Phase anl
Prospective Motion Correction using Inductively-Coupled Wireless RF Coils
Ooi, Melvyn B.; Aksoy, Murat; Maclaren, Julian; Watkins, Ronald D.; Bammer, Roland
2013-01-01
Purpose A novel prospective motion correction technique for brain MRI is presented that uses miniature wireless radio-frequency (RF) coils, or “wireless markers”, for position tracking. Methods Each marker is free of traditional cable connections to the scanner. Instead, its signal is wirelessly linked to the MR receiver via inductive coupling with the head coil. Real-time tracking of rigid head motion is performed using a pair of glasses integrated with three wireless markers. A tracking pulse-sequence, combined with knowledge of the markers’ unique geometrical arrangement, is used to measure their positions. Tracking data from the glasses is then used to prospectively update the orientation and position of the image-volume so that it follows the motion of the head. Results Wireless-marker position measurements were comparable to measurements using traditional wired RF tracking coils, with the standard deviation of the difference < 0.01 mm over the range of positions measured inside the head coil. RF safety was verified with B1 maps and temperature measurements. Prospective motion correction was demonstrated in a 2D spin-echo scan while the subject performed a series of deliberate head rotations. Conclusion Prospective motion correction using wireless markers enables high quality images to be acquired even during bulk motions. Wireless markers are small, avoid RF safety risks from electrical cables, are not hampered by mechanical connections to the scanner, and require minimal setup times. These advantages may help to facilitate adoption in the clinic. PMID:23813444
Qiu, Bensheng; El-Sharkawy, Abdel-Monem; Paliwal, Vaishali; Karmarkar, Parag; Gao, Fabao; Atalar, Ergin; Yang, Xiaoming
2005-07-01
Previous studies have confirmed the possibility of using an intravascular MR imaging guidewire (MRIG) as a heating source to enhance vascular gene transfection/expression. This motivated us to develop a new intravascular system that can perform MR imaging, radiofrequncy (RF) heating, and MR temperature monitoring simultaneously in an MR scanner. To validate this concept, a series of mathematical simulations of RF power loss along a 0.032-inch MRIG and RF energy spatial distribution were performed to determine the optimum RF heating frequency. Then, an RF generator/amplifier and a filter box were built. The possibility for simultaneous RF heating and MR thermal mapping of the system was confirmed in vitro using a phantom, and the obtained thermal mapping profile was compared with the simulated RF power distribution. Subsequently, the feasibility of simultaneous RF heating and temperature monitoring was successfully validated in vivo in the aorta of living rabbits. This MR imaging/RF heating system offers a potential tool for intravascular MR-mediated, RF-enhanced vascular gene therapy.
Development of a prototype chest digital tomosynthesis R/F system
NASA Astrophysics Data System (ADS)
Choi, Sunghoon; Lee, Haenghwa; Lee, Donghoon; Choi, Seungyeon; Shin, Jungwook; Jang, Woojin; Seo, Chang-Woo; Kim, Hee-Joung
2017-03-01
Digital tomosynthesis has an advantage of low radiation dose compared to conventional computed tomography (CT) by utilizing small number of projections ( 80) acquired over a limited angular range. It can produce 3D volumetric data although they may have some artifacts due to incomplete sampling. Based upon these attractive merits, we developed a prototype digital tomosynthesis R/F system especially for the purpose of applications in chest imaging. Prototype chest digital tomosynthesis (CDT) R/F system contains an X-ray tube with high power R/F pulse generator, flat-panel detector, R/F table, electromechanical radiographic subsystems including precise motor controller, and a reconstruction server. For image reconstruction, users could select the reconstruction option between analytic and iterative methods. Reconstructed images of Catphan700 and LUNGMAN phantoms clearly and rapidly described the internal structures of the phantoms using graphics processing unit (GPU) programming. Contrast-to-noise ratio (CNR) values of the CTP682 module was higher in images using the simultaneous algebraic reconstruction technique (SART) than those using filtered backprojection (FBP) for all materials by factors of 2.60, 3.78, 5.50, 2.30, 3.70, and 2.52 for air, lung foam, low density polyethylene (LDPE), Delrin (acetal homopolymer resin), bone 50% (hydroxyapatite), and Teflon, respectively. Total elapsed times for producing 3D volume were 2.92 sec and 86.29 sec on average for FBP and SART (20 iterations), respectively. The times required for reconstruction were clinically feasible. Moreover, the total radiation dose from the system (5.68 mGy) could demonstrate a significant lowered radiation dose compared to conventional chest CT scan. Consequently, our prototype tomosynthesis R/F system represents an important advance in digital tomosynthesis applications.
Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF.
Chen, Jiangtian; Reiher, Wencke; Hermann-Luibl, Christiane; Sellami, Azza; Cognigni, Paola; Kondo, Shu; Helfrich-Förster, Charlotte; Veenstra, Jan A; Wegener, Christian
2016-09-01
Feeding and sleep are fundamental behaviours with significant interconnections and cross-modulations. The circadian system and peptidergic signals are important components of this modulation, but still little is known about the mechanisms and networks by which they interact to regulate feeding and sleep. We show that specific thermogenetic activation of peptidergic Allatostatin A (AstA)-expressing PLP neurons and enteroendocrine cells reduces feeding and promotes sleep in the fruit fly Drosophila. The effects of AstA cell activation are mediated by AstA peptides with receptors homolog to galanin receptors subserving similar and apparently conserved functions in vertebrates. We further identify the PLP neurons as a downstream target of the neuropeptide pigment-dispersing factor (PDF), an output factor of the circadian clock. PLP neurons are contacted by PDF-expressing clock neurons, and express a functional PDF receptor demonstrated by cAMP imaging. Silencing of AstA signalling and continuous input to AstA cells by tethered PDF changes the sleep/activity ratio in opposite directions but does not affect rhythmicity. Taken together, our results suggest that pleiotropic AstA signalling by a distinct neuronal and enteroendocrine AstA cell subset adapts the fly to a digestive energy-saving state which can be modulated by PDF.
Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF
Reiher, Wencke; Hermann-Luibl, Christiane; Sellami, Azza; Cognigni, Paola; Helfrich-Förster, Charlotte; Veenstra, Jan A.
2016-01-01
Feeding and sleep are fundamental behaviours with significant interconnections and cross-modulations. The circadian system and peptidergic signals are important components of this modulation, but still little is known about the mechanisms and networks by which they interact to regulate feeding and sleep. We show that specific thermogenetic activation of peptidergic Allatostatin A (AstA)-expressing PLP neurons and enteroendocrine cells reduces feeding and promotes sleep in the fruit fly Drosophila. The effects of AstA cell activation are mediated by AstA peptides with receptors homolog to galanin receptors subserving similar and apparently conserved functions in vertebrates. We further identify the PLP neurons as a downstream target of the neuropeptide pigment-dispersing factor (PDF), an output factor of the circadian clock. PLP neurons are contacted by PDF-expressing clock neurons, and express a functional PDF receptor demonstrated by cAMP imaging. Silencing of AstA signalling and continuous input to AstA cells by tethered PDF changes the sleep/activity ratio in opposite directions but does not affect rhythmicity. Taken together, our results suggest that pleiotropic AstA signalling by a distinct neuronal and enteroendocrine AstA cell subset adapts the fly to a digestive energy-saving state which can be modulated by PDF. PMID:27689358
Savchenko, Tatyana; Walley, Justin W.; Chehab, E. Wassim; Xiao, Yanmei; Kaspi, Roy; Pye, Matthew F.; Mohamed, Maged E.; Lazarus, Colin M.; Bostock, Richard M.; Dehesh, Katayoon
2010-01-01
Fatty acid structure affects cellular activities through changes in membrane lipid composition and the generation of a diversity of bioactive derivatives. Eicosapolyenoic acids are released into plants upon infection by oomycete pathogens, suggesting they may elicit plant defenses. We exploited transgenic Arabidopsis thaliana plants (designated EP) producing eicosadienoic, eicosatrienoic, and arachidonic acid (AA), aimed at mimicking pathogen release of these compounds. We also examined their effect on biotic stress resistance by challenging EP plants with fungal, oomycete, and bacterial pathogens and an insect pest. EP plants exhibited enhanced resistance to all biotic challenges, except they were more susceptible to bacteria than the wild type. Levels of jasmonic acid (JA) were elevated and levels of salicylic acid (SA) were reduced in EP plants. Altered expression of JA and SA pathway genes in EP plants shows that eicosapolyenoic acids effectively modulate stress-responsive transcriptional networks. Exogenous application of various fatty acids to wild-type and JA-deficient mutants confirmed AA as the signaling molecule. Moreover, AA treatment elicited heightened expression of general stress-responsive genes. Importantly, tomato (Solanum lycopersicum) leaves treated with AA exhibited reduced susceptibility to Botrytis cinerea infection, confirming AA signaling in other plants. These studies support the role of AA, an ancient metazoan signaling molecule, in eliciting plant stress and defense signaling networks. PMID:20935246
Strong Recurrent Networks Compute the Orientation-Tuning of Surround Modulation in Primate V1
Shushruth, S.; Mangapathy, Pradeep; Ichida, Jennifer M.; Bressloff, Paul C.; Schwabe, Lars; Angelucci, Alessandra
2012-01-01
In macaque primary visual cortex (V1) neuronal responses to stimuli inside the receptive field (RF) are modulated by stimuli in the RF surround. This modulation is orientation-specific. Previous studies suggested that for some cells this specificity may not be fixed, but changes with the stimulus orientation presented to the RF. We demonstrate, in recording studies, that this tuning behavior is instead highly prevalent in V1 and, in theoretical work, that it arises only if V1 operates in a regime of strong local recurrence. Strongest surround suppression occurs when the stimuli in the RF and the surround are iso-oriented, and strongest facilitation when the stimuli are cross-oriented. This is the case even when the RF is sub-optimally activated by a stimulus of non-preferred orientation, but only if this stimulus can activate the cell when presented alone. This tuning behavior emerges from the interaction of lateral inhibition (via the surround pathways), which is tuned to the RF’s preferred orientation, with weakly-tuned, but strong, local recurrent connections, causing maximal withdrawal of recurrent excitation at the feedforward input orientation. Thus, horizontal and feedback modulation of strong recurrent circuits allows the tuning of contextual effects to change with changing feedforward inputs. PMID:22219292
Design and Implementation of RF Energy Harvesting System for Low-Power Electronic Devices
NASA Astrophysics Data System (ADS)
Uzun, Yunus
2016-08-01
Radio frequency (RF) energy harvester systems are a good alternative for energizing of low-power electronics devices. In this work, an RF energy harvester is presented to obtain energy from Global System for Mobile Communications (GSM) 900 MHz signals. The energy harvester, consisting of a two-stage Dickson voltage multiplier circuit and L-type impedance matching circuits, was designed, simulated, fabricated and tested experimentally in terms of its performance. Simulation and experimental works were carried out for various input power levels, load resistances and input frequencies. Both simulation and experimental works have been carried out for this frequency band. An efficiency of 45% is obtained from the system at 0 dBm input power level using the impedance matching circuit. This corresponds to the power of 450 μW and this value is sufficient for many low-power devices. The most important parameters affecting the efficiency of the RF energy harvester are the input power level, frequency band, impedance matching and voltage multiplier circuits, load resistance and the selection of diodes. RF energy harvester designs should be optimized in terms of these parameters.
P-code enhanced method for processing encrypted GPS signals without knowledge of the encryption code
NASA Technical Reports Server (NTRS)
Young, Lawrence E. (Inventor); Meehan, Thomas K. (Inventor); Thomas, Jr., Jess Brooks (Inventor)
2000-01-01
In the preferred embodiment, an encrypted GPS signal is down-converted from RF to baseband to generate two quadrature components for each RF signal (L1 and L2). Separately and independently for each RF signal and each quadrature component, the four down-converted signals are counter-rotated with a respective model phase, correlated with a respective model P code, and then successively summed and dumped over presum intervals substantially coincident with chips of the respective encryption code. Without knowledge of the encryption-code signs, the effect of encryption-code sign flips is then substantially reduced by selected combinations of the resulting presums between associated quadrature components for each RF signal, separately and independently for the L1 and L2 signals. The resulting combined presums are then summed and dumped over longer intervals and further processed to extract amplitude, phase and delay for each RF signal. Precision of the resulting phase and delay values is approximately four times better than that obtained from straight cross-correlation of L1 and L2. This improved method provides the following options: separate and independent tracking of the L1-Y and L2-Y channels; separate and independent measurement of amplitude, phase and delay L1-Y channel; and removal of the half-cycle ambiguity in L1-Y and L2-Y carrier phase.
Measurement of RF propagation around corners in underground mines and tunnels
Jacksha, R.; Zhou, C.
2017-01-01
This paper reports measurement results for radio frequency (RF) propagation around 90° corners in tunnels and underground mines, for vertically, horizontally and longitudinally polarized signals. Measurements of signal power attenuation from a main entry into a crosscut were performed at four frequencies — 455, 915, 2450 and 5800 MHz — that are common to underground radio communication systems. From the measurement data, signal power loss was determined as a function of signal coupling from the main entry into the crosscut. The resultant power loss data show there are many factors that contribute to power attenuation from a main entry into a crosscut, including frequency, antenna polarization and cross-sectional entry dimensions. PMID:28626351
Kindrachuk, Jason; Wahl-Jensen, Victoria; Safronetz, David; Trost, Brett; Hoenen, Thomas; Arsenault, Ryan; Feldmann, Friederike; Traynor, Dawn; Postnikova, Elena; Kusalik, Anthony; Napper, Scott; Blaney, Joseph E; Feldmann, Heinz; Jahrling, Peter B
2014-09-01
Ebola virus (EBOV) causes a severe hemorrhagic disease in humans and nonhuman primates, with a median case fatality rate of 78.4%. Although EBOV is considered a public health concern, there is a relative paucity of information regarding the modulation of the functional host response during infection. We employed temporal kinome analysis to investigate the relative early, intermediate, and late host kinome responses to EBOV infection in human hepatocytes. Pathway overrepresentation analysis and functional network analysis of kinome data revealed that transforming growth factor (TGF-β)-mediated signaling responses were temporally modulated in response to EBOV infection. Upregulation of TGF-β signaling in the kinome data sets correlated with the upregulation of TGF-β secretion from EBOV-infected cells. Kinase inhibitors targeting TGF-β signaling, or additional cell receptors and downstream signaling pathway intermediates identified from our kinome analysis, also inhibited EBOV replication. Further, the inhibition of select cell signaling intermediates identified from our kinome analysis provided partial protection in a lethal model of EBOV infection. To gain perspective on the cellular consequence of TGF-β signaling modulation during EBOV infection, we assessed cellular markers associated with upregulation of TGF-β signaling. We observed upregulation of matrix metalloproteinase 9, N-cadherin, and fibronectin expression with concomitant reductions in the expression of E-cadherin and claudin-1, responses that are standard characteristics of an epithelium-to-mesenchyme-like transition. Additionally, we identified phosphorylation events downstream of TGF-β that may contribute to this process. From these observations, we propose a model for a broader role of TGF-β-mediated signaling responses in the pathogenesis of Ebola virus disease. Ebola virus (EBOV), formerly Zaire ebolavirus, causes a severe hemorrhagic disease in humans and nonhuman primates and is the most
Wahl-Jensen, Victoria; Safronetz, David; Trost, Brett; Hoenen, Thomas; Arsenault, Ryan; Feldmann, Friederike; Traynor, Dawn; Postnikova, Elena; Kusalik, Anthony; Napper, Scott; Blaney, Joseph E.; Feldmann, Heinz; Jahrling, Peter B.
2014-01-01
ABSTRACT Ebola virus (EBOV) causes a severe hemorrhagic disease in humans and nonhuman primates, with a median case fatality rate of 78.4%. Although EBOV is considered a public health concern, there is a relative paucity of information regarding the modulation of the functional host response during infection. We employed temporal kinome analysis to investigate the relative early, intermediate, and late host kinome responses to EBOV infection in human hepatocytes. Pathway overrepresentation analysis and functional network analysis of kinome data revealed that transforming growth factor (TGF-β)-mediated signaling responses were temporally modulated in response to EBOV infection. Upregulation of TGF-β signaling in the kinome data sets correlated with the upregulation of TGF-β secretion from EBOV-infected cells. Kinase inhibitors targeting TGF-β signaling, or additional cell receptors and downstream signaling pathway intermediates identified from our kinome analysis, also inhibited EBOV replication. Further, the inhibition of select cell signaling intermediates identified from our kinome analysis provided partial protection in a lethal model of EBOV infection. To gain perspective on the cellular consequence of TGF-β signaling modulation during EBOV infection, we assessed cellular markers associated with upregulation of TGF-β signaling. We observed upregulation of matrix metalloproteinase 9, N-cadherin, and fibronectin expression with concomitant reductions in the expression of E-cadherin and claudin-1, responses that are standard characteristics of an epithelium-to-mesenchyme-like transition. Additionally, we identified phosphorylation events downstream of TGF-β that may contribute to this process. From these observations, we propose a model for a broader role of TGF-β-mediated signaling responses in the pathogenesis of Ebola virus disease. IMPORTANCE Ebola virus (EBOV), formerly Zaire ebolavirus, causes a severe hemorrhagic disease in humans and nonhuman
Stimulation of the Locus Ceruleus Modulates Signal-to-Noise Ratio in the Olfactory Bulb.
Manella, Laura C; Petersen, Nicholas; Linster, Christiane
2017-11-29
Norepinephrine (NE) has been shown to influence sensory, and specifically olfactory processing at the behavioral and physiological levels, potentially by regulating signal-to-noise ratio (S/N). The present study is the first to look at NE modulation of olfactory bulb (OB) in regards to S/N in vivo We show, in male rats, that locus ceruleus stimulation and pharmacological infusions of NE into the OB modulate both spontaneous and odor-evoked neural responses. NE in the OB generated a non-monotonic dose-response relationship, suppressing mitral cell activity at high and low, but not intermediate, NE levels. We propose that NE enhances odor responses not through direct potentiation of the afferent signal per se, but rather by reducing the intrinsic noise of the system. This has important implications for the ways in which an animal interacts with its olfactory environment, particularly as the animal shifts from a relaxed to an alert behavioral state. SIGNIFICANCE STATEMENT Sensory perception can be modulated by behavioral states such as hunger, fear, stress, or a change in environmental context. Behavioral state often affects neural processing via the release of circulating neurochemicals such as hormones or neuromodulators. We here show that the neuromodulator norepinephrine modulates olfactory bulb spontaneous activity and odor responses so as to generate an increased signal-to-noise ratio at the output of the olfactory bulb. Our results help interpret and improve existing ideas for neural network mechanisms underlying behaviorally observed improvements in near-threshold odor detection and discrimination. Copyright © 2017 the authors 0270-6474/17/3711605-11$15.00/0.
Tight Junction–Associated Signaling Pathways Modulate Cell Proliferation in Uveal Melanoma
Jayagopal, Ashwath; Yang, Jin-Long; Haselton, Frederick R.; Chang, Min S.
2011-01-01
Purpose. To investigate the role of tight junction (TJ)–associated signaling pathways in the proliferation of uveal melanoma. Methods. Human uveal melanoma cell lines overexpressing the TJ molecule blood vessel epicardial substance (Bves) were generated. The effects of Bves overexpression on TJ protein expression, cell proliferation, and cell cycle distribution were quantified. In addition, localization and transcription activity of the TJ-associated protein ZO-1–associated nucleic acid binding protein (ZONAB) were evaluated using immunofluorescence and bioluminescence reporter assays to study the involvement of Bves signaling in cell proliferation-associated pathways. Results. Bves overexpression in uveal melanoma cell lines resulted in increased expression of the TJ proteins occludin and ZO-1, reduced cell proliferation, and increased sequestration of ZONAB at TJs and reduced ZONAB transcriptional activity. Conclusions. TJ proteins are present in uveal melanoma, and TJ-associated signaling pathways modulate cell signaling pathways relevant to proliferation in uveal melanoma. PMID:20861479
An extraordinary tabletop speed of light apparatus
NASA Astrophysics Data System (ADS)
Pegna, Guido
2017-09-01
A compact, low-cost, pre-aligned apparatus of the modulation type is described. The apparatus allows accurate determination of the speed of light in free propagation with an accuracy on the order of one part in 104. Due to the 433.92 MHz radio frequency (rf) modulation of its laser diode, determination of the speed of light is possible within a sub-meter measuring base and in small volumes (some cm3) of transparent solids or liquids. No oscilloscope is necessary, while the required function generators, power supplies, and optical components are incorporated into the design of the apparatus and its receiver can slide along the optical bench while maintaining alignment with the laser beam. Measurement of the velocity factor of coaxial cables is also easily performed. The apparatus detects the phase difference between the rf modulation of the laser diode by further modulating the rf signal with an audio frequency signal; the phase difference between these signals is then observed as the loudness of the audio signal. In this way, the positions at which the minima of the audio signal are found determine where the rf signals are completely out of phase. This phase detection method yields a much increased sensitivity with respect to the display of coincidence of two signals of questionable arrival time and somewhat distorted shape on an oscilloscope. The displaying technique is also particularly suitable for large audiences as well as in unattended exhibits in museums and science centers. In addition, the apparatus can be set up in less than one minute.
Rasper, Michael; Nadjiri, Jonathan; Sträter, Alexandra S; Settles, Marcus; Laugwitz, Karl-Ludwig; Rummeny, Ernst J; Huber, Armin M
2017-06-01
To prospectively compare image quality and myocardial T 1 relaxation times of modified Look-Locker inversion recovery (MOLLI) imaging at 3.0 T (T) acquired with patient-adaptive dual-source (DS) and conventional single-source (SS) radiofrequency (RF) transmission. Pre- and post-contrast MOLLI T 1 mapping using SS and DS was acquired in 27 patients. Patient wise and segment wise analysis of T 1 times was performed. The correlation of DS MOLLI measurements with a reference spin echo sequence was analysed in phantom experiments. DS MOLLI imaging reduced T 1 standard deviation in 14 out of 16 myocardial segments (87.5%). Significant reduction of T 1 variance could be obtained in 7 segments (43.8%). DS significantly reduced myocardial T 1 variance in 16 out of 25 patients (64.0%). With conventional RF transmission, dielectric shading artefacts occurred in six patients causing diagnostic uncertainty. No according artefacts were found on DS images. DS image findings were in accordance with conventional T 1 mapping and late gadolinium enhancement (LGE) imaging. Phantom experiments demonstrated good correlation of myocardial T 1 time between DS MOLLI and spin echo imaging. Dual-source RF transmission enhances myocardial T 1 homogeneity in MOLLI imaging at 3.0 T. The reduction of signal inhomogeneities and artefacts due to dielectric shading is likely to enhance diagnostic confidence.
Microcontroller-based wireless recorder for biomedical signals.
Chien, C-N; Hsu, H-W; Jang, J-K; Rau, C-L; Jaw, F-S
2005-01-01
A portable multichannel system is described for the recording of biomedical signals wirelessly. Instead of using the conversional time-division analog-modulation method, the technique of digital multiplexing was applied to increase the number of signal channels to 4. Detailed design considerations and functional allocation of the system is discussed. The frontend unit was modularly designed to condition the input signal in an optimal manner. Then, the microcontroller handled the tasks of data conversion, wireless transmission, as well as providing the ability of simple preprocessing such as waveform averaging or rectification. The low-power nature of this microcontroller affords the benefit of battery operation and hence, patient isolation of the system. Finally, a single-chip receiver, which compatible with the RF transmitter of the microcontroller, was used to implement a compact interface with the host computer. An application of this portable recorder for low-back pain studies is shown. This device can simultaneously record one ECG and two surface EMG wirelessly, thus, is helpful in relieving patients' anxiety devising clinical measurement. Such an approach, microcontroller-based wireless measurement, could be an important trend for biomedical instrumentation and we help that this paper could be useful for other colleagues.
Design and research of RF system for 10 MeV compact cyclotron
NASA Astrophysics Data System (ADS)
Li, Dong; Hu, TongNing; Liu, KaiFeng; Yang, Jun
2011-12-01
A 10 MeV compact cyclotron (CYCHU-10) has been developing in Huazhong University of Science and Technology (HUST). The RF system includes a 10 kW RF power generator and a resonance cavity. There is no automatic frequency tuning equipment in the cavity due to space limitations, so the generator must search and track the cavity resonant frequency. AD9850 synthesizer is used to generate RF signal in the experimental prototype, and a fine sinusoidal waveform around 99 MHz is obtained with the method of picking up a special aliased signal from the synthesizer's output, and the output power level can be set by regulating the resistor connected to the Pin ` R set'. The final stage amplifier based on tetrode operates in the grounded cathode configuration, and the schematic of the tetrode circuit is illustrated. The method of searching the resonant frequency is discussed in detail. For the sake of a compact and robust structure, the resonance cavity will adopt non-uniform characteristic impedance coaxial structure, and the magnet surface electroplated with copper will be used as dummy Dees. The precise shapes and dimensions of the cavity are designed and simulation results are carried out in this paper. The distributions of electromagnetic field are illustrated by means of numerical calculation analysis, and the wooden model test is preformed as well.
Young, Adelaide Ij; Timpson, Paul; Gallego-Ortega, David; Ormandy, Christopher J; Oakes, Samantha R
2017-12-21
Myeloid cell leukemia-1 (MCL-1), closely related to B-cell lymphoma 2 (BCL-2), has a well-established role in cell survival and has emerged as an important target for cancer therapeutics. We have demonstrated that inhibiting MCL-1 is efficacious in suppressing tumour progression in pre-clinical models of breast cancer and revealed that in addition to its role in cell survival, MCL-1 modulated cellular invasion. Utilizing a MCL-1-specific genetic antagonist, we found two possible mechanisms; firstly MCL-1 directly binds to and alters the phosphorylation of the cytoskeletal remodeling protein, Cofilin, a protein important for cytoskeletal remodeling during invasion, and secondly MCL-1 modulates the levels SRC family kinases (SFKs) and their targets. These data provide evidence that MCL-1 activities are not limited to endpoints of extracellular and intracellular signaling culminating in cell survival as previously thought, but can directly modulate the output of SRC family kinases signaling during cellular invasion. Here we review the pleotropic roles of MCL-1 and discuss the implications of this newly discovered effect on protein kinase signaling for the development of cancer therapeutics.
Intercepted signals for ionospheric science
NASA Astrophysics Data System (ADS)
Lind, F. D.; Erickson, P. J.; Coster, A. J.; Foster, J. C.; Marchese, J. R.; Berkowitz, Z.; Sahr, J. D.
2013-05-01
The ISIS array (Intercepted Signals for Ionospheric Science) is a distributed, coherent software radio array designed for the study of geospace phenomena by observing the scatter of ambient radio frequency (RF) signals. ISIS data acquisition and analysis is performed using the MIDAS-M platform (Millstone Data Acquisition System - Mobile). Observations of RF signals can be performed between HF and L-band using the Array nodes and appropriate antennas. The deployment of the Array focuses on observations of the plasmasphere boundary layer. We discuss the concept of the coherent software radio array, describe the ISIS hardware, and give examples of data from the system for selected applications. In particular, we include the first observations of E region irregularities using the Array. We also present single-site passive radar observations of both meteor trails and E region irregularities using adaptive filtering techniques.
Direct Modulation of Heterotrimeric G Protein-coupled Signaling by a Receptor Kinase Complex.
Tunc-Ozdemir, Meral; Urano, Daisuke; Jaiswal, Dinesh Kumar; Clouse, Steven D; Jones, Alan M
2016-07-01
Plants and some protists have heterotrimeric G protein complexes that activate spontaneously without canonical G protein-coupled receptors (GPCRs). In Arabidopsis, the sole 7-transmembrane regulator of G protein signaling 1 (AtRGS1) modulates the G protein complex by keeping it in the resting state (GDP-bound). However, it remains unknown how a myriad of biological responses is achieved with a single G protein modulator. We propose that in complete contrast to G protein activation in animals, plant leucine-rich repeat receptor-like kinases (LRR RLKs), not GPCRs, provide this discrimination through phosphorylation of AtRGS1 in a ligand-dependent manner. G protein signaling is directly activated by the pathogen-associated molecular pattern flagellin peptide 22 through its LRR RLK, FLS2, and co-receptor BAK1. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.
Measured performance of the GTA rf systems
DOE Office of Scientific and Technical Information (OSTI.GOV)
Denney, P.M.; Jachim, S.P.
1993-06-01
This paper describes the performance of the RF systems on the Ground Test Accelerator (GTA). The RF system architecture is briefly described. Among the RF performance results presented are RF field flatness and stability, amplitude and phase control resolution, and control system bandwidth and stability. The rejection by the RF systems of beam-induced disturbances, such as transients and noise, are analyzed. The observed responses are also compared to computer-based simulations of the RF systems for validation.
Measured performance of the GTA rf systems
DOE Office of Scientific and Technical Information (OSTI.GOV)
Denney, P.M.; Jachim, S.P.
1993-01-01
This paper describes the performance of the RF systems on the Ground Test Accelerator (GTA). The RF system architecture is briefly described. Among the RF performance results presented are RF field flatness and stability, amplitude and phase control resolution, and control system bandwidth and stability. The rejection by the RF systems of beam-induced disturbances, such as transients and noise, are analyzed. The observed responses are also compared to computer-based simulations of the RF systems for validation.
Pregnant Women Models Analyzed for RF Exposure and Temperature Increase in 3T RF Shimmed Birdcages
Murbach, Manuel; Neufeld, Esra; Samaras, Theodoros; Córcoles, Juan; Robb, Fraser J.; Kainz, Wolfgang; Kuster, Niels
2017-01-01
Purpose MRI is increasingly used to scan pregnant patients. We investigated the effect of 3 Tesla (T) two-port radiofrequency (RF) shimming in anatomical pregnant women models. Theory and Methods RF shimming improves B1+ uniformity, but may at the same time significantly alter the induced current distribution and result in large changes in both the level and location of the absorbed RF energy. In this study, we evaluated the electrothermal exposure of pregnant women in the third, seventh, and ninth month of gestation at various imaging landmarks in RF body coils, including modes with RF shimming. Results Although RF shimmed configurations may lower the local RF exposure for the mother, they can increase the thermal load on the fetus. In worst-case configurations, whole-body exposure and local peak temperatures—up to 40.8°C—are equal in fetus and mother. Conclusions Two-port RF shimming can significantly increase the fetal exposure in pregnant women, requiring further research to derive a very robust safety management. For the time being, restriction to the CP mode, which reduces fetal SAR exposure compared with linear-horizontal polarization modes, may be advisable. Results from this study do not support scanning pregnant patients above the normal operating mode. PMID:27174499
A subsequent closed-form description of propagated signaling phenomena in the membrane of an axon
DOE Office of Scientific and Technical Information (OSTI.GOV)
Melendy, Robert F., E-mail: rfmelendy@liberty.edu
2016-05-15
I recently introduced a closed-form description of propagated signaling phenomena in the membrane of an axon [R.F. Melendy, Journal of Applied Physics 118, 244701 (2015)]. Those results demonstrate how intracellular conductance, the thermodynamics of magnetization, and current modulation, function together in generating an action potential in a unified, closed-form description. At present, I report on a subsequent closed-form model that unifies intracellular conductance and the thermodynamics of magnetization, with the membrane electric field, E{sub m}. It’s anticipated this work will compel researchers in biophysics, physical biology, and the computational neurosciences, to probe deeper into the classical and quantum features ofmore » membrane magnetization and signaling, informed by the computational features of this subsequent model.« less
Flexible RF filter using a nonuniform SCISSOR.
Zhuang, Leimeng
2016-03-15
This work presents a flexible radiofrequency (RF) filter using an integrated microwave photonic circuit that comprises a nonuniform side-coupled integrated spaced sequence of resonators (N-SCISSOR). The filter passband can be reconfigured by varying the N-SCISSOR parameters. When employing a dual-parallel Mach-Zechnder modulator, the filter is also able to perform frequency down-conversion. In the experiment, various filter response shapes are shown, ranging from a flat-top band-pass filter to a total opposite high-rejection (>40 dB) notch filter, with a frequency coverage of greater than two octaves. The frequency down-conversion function is also demonstrated.
Modular compact solid-state modulators for particle accelerators
NASA Astrophysics Data System (ADS)
Zavadtsev, A. A.; Zavadtsev, D. A.; Churanov, D. V.
2017-12-01
The building of the radio frequency (RF) particle accelerator needs high-voltage pulsed modulator as a power supply for klystron or magnetron to feed the RF accelerating system. The development of a number of solid-state modulators for use in linear accelerators has allowed to develop a series of modular IGBT based compact solid-state modulators with different parameters. This series covers a wide range of needs in accelerator technology to feed a wide range of loads from the low power magnetrons to powerful klystrons. Each modulator of the series is built on base of a number of unified solid-state modules connected to the pulse transformer, and covers a wide range of modulators: voltage up to 250 kV, a peak current up to 250 A, average power up to 100 kW and the pulse duration up to 20 μsec. The parameters of the block with an overall dimensions 880×540×250 mm are: voltage 12 kV, peak current 1600 A, pulse duration 20 μsec, average power 10 kW with air-cooling and 40 kW with liquidcooling. These parameters do not represent a physical limit, and modulators to parameters outside these ranges can be created on request.
IEEE-802.15.4-based low-power body sensor node with RF energy harvester.
Tran, Thang Viet; Chung, Wan-Young
2014-01-01
This paper proposes the design and implementation of a low-voltage and low-power body sensor node based on the IEEE 802.15.4 standard to collect electrocardiography (ECG) and photoplethysmography (PPG) signals. To achieve compact size, low supply voltage, and low power consumption, the proposed platform is integrated into a ZigBee mote, which contains a DC-DC booster, a PPG sensor interface module, and an ECG front-end circuit that has ultra-low current consumption. The input voltage of the proposed node is very low and has a wide range, from 0.65 V to 3.3 V. An RF energy harvester is also designed to charge the battery during the working mode or standby mode of the node. The power consumption of the proposed node reaches 14 mW in working mode to prolong the battery lifetime. The software is supported by the nesC language under the TinyOS environment, which enables the proposed node to be easily configured to function as an individual health monitoring node or a node in a wireless body sensor network (BSN). The proposed node is used to set up a wireless BSN that can simultaneously collect ECG and PPG signals and monitor the results on the personal computer.
Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats.
Elsonbaty, Sawsan M; Zahran, Walid E; Moawed, Fatma Sm
2017-08-01
β-glucans are one of the most abundant forms of polysaccharides known as biological response modifiers which influence host's biological response and stimulate immune system. Accordingly, this study was initiated to evaluate irradiated β-glucan as a modulator for cellular signaling growth factors involved in the pathogenesis of hepatocellular carcinoma in rats. Hepatocellular carcinoma was induced with 20 mg diethylnitrosamine/kg BW. Rats received daily by gastric gavage 65 mg irradiated β-glucan/kg BW. It was found that treatment of rats with diethylnitrosamine induced hepatic injury and caused significant increase in liver injury markers with a concomitant significant increase in both hepatic oxidative and inflammatory indices: alpha-fetoprotein, interferon gamma, and interleukin 6 in comparison with normal and irradiated β-glucan-treated groups. Western immunoblotting showed a significant increase in the signaling growth factors: extracellular signal-regulated kinase 1 and phosphoinositide 3-kinase proteins in a diethylnitrosamine-treated group while both preventive and therapeutic irradiated β-glucan treatments recorded significant improvement versus diethylnitrosamine group via the modulation of growth factors that encounters hepatic toxicity. The transcript levels of vascular endothelial growth factor A and inducible nitric oxide synthase genes were significantly higher in the diethylnitrosamine-treated group in comparison with controls. Preventive and therapeutic treatments with irradiated β-glucan demonstrated that the transcript level of these genes was significantly decreased which demonstrates the protective effect of β-glucan. Histological investigations revealed that diethylnitrosamine treatment affects the hepatic architecture throughout the significant severe appearance of inflammatory cell infiltration in the portal area and congestion in the portal vein in association with severe degeneration and dysplasia in hepatocytes all over hepatic
Mora, Liliana; Heurgué-Hamard, Valérie; de Zamaroczy, Miklos; Kervestin, Stephanie; Buckingham, Richard H
2007-12-07
Bacterial release factors RF1 and RF2 are methylated on the Gln residue of a universally conserved tripeptide motif GGQ, which interacts with the peptidyl transferase center of the large ribosomal subunit, triggering hydrolysis of the ester bond in peptidyl-tRNA and releasing the newly synthesized polypeptide from the ribosome. In vitro experiments have shown that the activity of RF2 is stimulated by Gln methylation. The viability of Escherichia coli K12 strains depends on the integrity of the release factor methyltransferase PrmC, because K12 strains are partially deficient in RF2 activity due to the presence of a Thr residue at position 246 instead of Ala. Here, we study in vivo RF1 and RF2 activity at termination codons in competition with programmed frameshifting and the effect of the Ala-246 --> Thr mutation. PrmC inactivation reduces the specific termination activity of RF1 and RF2(Ala-246) by approximately 3- to 4-fold. The mutation Ala-246 --> Thr in RF2 reduces the termination activity in cells approximately 5-fold. After correction for the decrease in level of RF2 due to the autocontrol of RF2 synthesis, the mutation Ala-246 --> Thr reduced RF2 termination activity by approximately 10-fold at UGA codons and UAA codons. PrmC inactivation had no effect on cell growth in rich media but reduced growth considerably on poor carbon sources. This suggests that the expression of some genes needed for optimal growth under such conditions can become growth limiting as a result of inefficient translation termination.
On-Board Fiber-Optic Network Architectures for Radar and Avionics Signal Distribution
NASA Technical Reports Server (NTRS)
Alam, Mohammad F.; Atiquzzaman, Mohammed; Duncan, Bradley B.; Nguyen, Hung; Kunath, Richard
2000-01-01
Continued progress in both civil and military avionics applications is overstressing the capabilities of existing radio-frequency (RF) communication networks based on coaxial cables on board modem aircrafts. Future avionics systems will require high-bandwidth on- board communication links that are lightweight, immune to electromagnetic interference, and highly reliable. Fiber optic communication technology can meet all these challenges in a cost-effective manner. Recently, digital fiber-optic communication systems, where a fiber-optic network acts like a local area network (LAN) for digital data communications, have become a topic of extensive research and development. Although a fiber-optic system can be designed to transport radio-frequency (RF) signals, the digital fiber-optic systems under development today are not capable of transporting microwave and millimeter-wave RF signals used in radar and avionics systems on board an aircraft. Recent advances in fiber optic technology, especially wavelength division multiplexing (WDM), has opened a number of possibilities for designing on-board fiber optic networks, including all-optical networks for radar and avionics RF signal distribution. In this paper, we investigate a number of different novel approaches for fiber-optic transmission of on-board VHF and UHF RF signals using commercial off-the-shelf (COTS) components. The relative merits and demerits of each architecture are discussed, and the suitability of each architecture for particular applications is pointed out. All-optical approaches show better performance than other traditional approaches in terms of signal-to-noise ratio, power consumption, and weight requirements.
Shankar, Jayendra; Walker, Rachel G; Wilkinson, Mark C; Ward, Deborah; Horsburgh, Malcolm J
2012-07-01
The culture supernatant fraction of an Enterococcus faecalis gelE mutant of strain OG1RF contained elevated levels of the secreted antigen SalB. Using differential fluorescence gel electrophoresis (DIGE) the salB mutant was shown to possess a unique complement of exoproteins. Differentially abundant exoproteins were identified using matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry. Stress-related proteins including DnaK, Dps family protein, SOD, and NADH peroxidase were present in greater quantity in the OG1RF salB mutant culture supernatant. Moreover, several proteins involved in cell wall synthesis and cell division, including d-Ala-d-Lac ligase and EzrA, were present in reduced quantity in OG1RF salB relative to the parent strain. The salB mutant displayed reduced viability and anomalous cell division, and these phenotypes were exacerbated in a gelE salB double mutant. An epistatic relationship between gelE and salB was not identified with respect to increased autolysis and cell morphological changes observed in the salB mutant. SalB was purified as a six-histidine-tagged protein to investigate peptidoglycan hydrolytic activity; however, activity was not evident. High-pressure liquid chromatography (HPLC) analysis of reduced muropeptides from peptidoglycan digested with mutanolysin revealed that the salB mutant and OG1RF were indistinguishable.
A Micromechanical RF Channelizer
NASA Astrophysics Data System (ADS)
Akgul, Mehmet
The power consumption of a radio generally goes as the number and strength of the RF signals it must process. In particular, a radio receiver would consume much less power if the signal presented to its electronics contained only the desired signal in a tiny percent bandwidth frequency channel, rather than the typical mix of signals containing unwanted energy outside the desired channel. Unfortunately, a lack of filters capable of selecting single channel bandwidths at RF forces the front-ends of contemporary receivers to accept unwanted signals, and thus, to operate with sub-optimal efficiency. This dissertation focuses on the degree to which capacitive-gap transduced micromechanical resonators can achieve the aforementioned RF channel-selecting filters. It aims to first show theoretically that with appropriate scaling capacitive-gap transducers are strong enough to meet the needed coupling requirements; and second, to fully detail an architecture and design procedure needed to realize said filters. Finally, this dissertation provides an actual experimentally demonstrated RF channel-select filter designed using the developed procedures and confirming theoretical predictions. Specifically, this dissertation introduces four methods that make possible the design and fabrication of RF channel-select filters. The first of these introduces a small-signal equivalent circuit for parallel-plate capacitive-gap transduced micromechanical resonators that employs negative capacitance to model the dependence of resonance frequency on electrical stiffness in a way that facilitates the analysis of micromechanical circuits loaded with arbitrary electrical impedances. The new circuit model not only correctly predicts the dependence of electrical stiffness on the impedances loading the input and output electrodes of parallel-plate capacitive-gap transduced micromechanical device, but does so in a visually intuitive way that identifies current drive as most appropriate for
Hybrid photonic signal processing
NASA Astrophysics Data System (ADS)
Ghauri, Farzan Naseer
This thesis proposes research of novel hybrid photonic signal processing systems in the areas of optical communications, test and measurement, RF signal processing and extreme environment optical sensors. It will be shown that use of innovative hybrid techniques allows design of photonic signal processing systems with superior performance parameters and enhanced capabilities. These applications can be divided into domains of analog-digital hybrid signal processing applications and free-space---fiber-coupled hybrid optical sensors. The analog-digital hybrid signal processing applications include a high-performance analog-digital hybrid MEMS variable optical attenuator that can simultaneously provide high dynamic range as well as high resolution attenuation controls; an analog-digital hybrid MEMS beam profiler that allows high-power watt-level laser beam profiling and also provides both submicron-level high resolution and wide area profiling coverage; and all optical transversal RF filters that operate on the principle of broadband optical spectral control using MEMS and/or Acousto-Optic tunable Filters (AOTF) devices which can provide continuous, digital or hybrid signal time delay and weight selection. The hybrid optical sensors presented in the thesis are extreme environment pressure sensors and dual temperature-pressure sensors. The sensors employ hybrid free-space and fiber-coupled techniques for remotely monitoring a system under simultaneous extremely high temperatures and pressures.
Liu, Xianwen; Sun, Changzheng; Xiong, Bing; Wang, Jian; Wang, Lai; Han, Yanjun; Hao, Zhibiao; Li, Hongtao; Luo, Yi; Yan, Jianchang; Wei, Tong Bo; Zhang, Yun; Wang, Junxi
2016-08-01
An all-optically tunable microwave photonic phase shifter is demonstrated based on an epitaxial aluminum nitride (AlN) microring with an intrinsic quality factor of 3.2×106. The microring adopts a pedestal structure, which allows overcoupling with 700 nm gap size and facilitates the fabrication process. A phase shift for broadband signals from 4 to 25 GHz is demonstrated by employing the thermo-optic effect and the separate carrier tuning technique. A phase tuning range of 0°-332° is recorded with a 3 dB radio frequency (RF) power variation and 48 mW optical power consumption. In addition, AlN exhibits intrinsic second-order optical nonlinearity. Thus, our work presents a novel platform with a low propagation loss and the capability of electro-optic modulation for applications in integrated microwave photonics.
Ground Isolation Circuit for Isolating a Transmission Line from Ground Interference
NASA Technical Reports Server (NTRS)
Davidson, Craig A. (Inventor)
1996-01-01
This invention relates generally to a system for isolating ground interference from a transmission line, e.g., a ground isolation circuit for isolating a wideband transmission signal (such as a video signal) from ground by modulating the base signal on a carrier signal to permit the transmission signal to be isolated. In one embodiment, the circuit includes a pair of matched mixer circuits, each of which receives a carrier signal from the same oscillator circuit. The first mixer circuit also receives the baseband signal input, after appropriate conditioning, and modulates the baseband signal onto the carrier signal. In a preferred embodiment the carrier signal has a predetermined frequency which is at least two times the frequency of the baseband signal. The modulated signal (which can comprise an rf signal) is transmitted via an rf transmission line to the second mixer, which demodulates the rf signal to recover the baseband signal. Each port of the mixer connects to an isolation transformer to ensure isolation from ground interference. The circuit is considered to be of commercial value in that it can provide isolation between transmitting and receiving circuits, e.g., ground isolation for television circuits or high frequency transmitters, without the need for video transformers or optical isolators, thereby reducing the complexity, power consumption, and weight of the system.
Installation and Commissioning of the Super Conducting RF Linac Cryomodules for the Erlp
NASA Astrophysics Data System (ADS)
Goulden, A. R.; Bate, R.; Buckley, R. K.; Pattalwar, S. M.
2008-03-01
An Energy Recovery Linac Prototype (ERLP) is currently being constructed at Daresbury Laboratory, (UK) to promote the necessary skills in science & technology, particularly in photocathode electron gun and Superconducting RF (SRF), to enable the construction of a fourth generation light source, based on energy recovery linacs-4GLS [1]. The ERLP uses two identical cryomodules, one as a booster Linac used to accelerate the beam to 8.5 MeV, the other as an Energy Recovery Linac (ERL) module with an energy gain of 26.5 MeV. Each module consists of two 9- cell cavities operating at a frequency of 1.3 GHz and a temperature of 2 K. As there is no energy recovery in the booster it requires a peak power of 53 kW; whereas the linac module only requires 8 kW. The RF power is supplied by Inductive Output Tube (IOT) amplifiers. The maximum heat load (or the cooling power) required in the SRF system is 180 W at 2 K and is achieved in two stages: a LN2 pre-cooled Linde TCF50 liquefier produces liquid helium at 4.5 K, followed by a 2 K cold box consisting of a JT valve, recuperator and an external room temperature vacuum pumping system. This presentation reports the experience gained during, installation, commissioning and the initial operation of the cryomodules.
Coherent detection of THz laser signals in optical fiber systems.
Folland, Thomas G; Marshall, Owen P; Beere, Harvey E; Ritchie, David A; Chakraborty, Subhasish
2017-10-16
Terahertz (THz) coherent detectors are crucial for the stabilization and measurement of the properties of quantum cascade lasers (QCLs). This paper describes the exploitation of intra-cavity sum frequency generation to up-convert the emission of a THz QCL to the near infrared for detection with fiber optic coupled components alone. Specifically, a low cost infrared photodiode is used to detect a radio frequency (RF) signal with a signal-to-noise ratio of approximately 20dB, generated by beating the up-converted THz wave and a near infrared local oscillator. This RF beat note allows direct analysis of the THz QCL emission in time and frequency domains. The application of this technique for QCL characterization is demonstrated by analyzing the continuous tuning of the RF signal over 2 GHz, which arises from mode tuning across the QCL's operational current range.
RF control hardware design for CYCIAE-100 cyclotron
NASA Astrophysics Data System (ADS)
Yin, Zhiguo; Fu, Xiaoliang; Ji, Bin; Zhao, Zhenlu; Zhang, Tianjue; Li, Pengzhan; Wei, Junyi; Xing, Jiansheng; Wang, Chuan
2015-11-01
The Beijing Radioactive Ion-beam Facility project is being constructed by BRIF division of China Institute of Atomic Energy. In this project, a 100 MeV high intensity compact proton cyclotron is built for multiple applications. The first successful beam extraction of CYCIAE-100 cyclotron was done in the middle of 2014. The extracted proton beam energy is 100 MeV and the beam current is more than 20 μA. The RF system of the CYCIAE-100 cyclotron includes two half-wavelength cavities, two 100 kW tetrode amplifiers and power transmission line systems (all above are independent from each other) and two sets of Low Level RF control crates. Each set of LLRF control includes an amplitude control unit, a tuning control unit, a phase control unit, a local Digital Signal Process control unit and an Advanced RISC Machines based EPICS IOC unit. These two identical LLRF control crates share one common reference clock and take advantages of modern digital technologies (e.g. DSP and Direct Digital Synthesizer) to achieve closed loop voltage and phase regulations of the dee-voltage. In the beam commission, the measured dee-voltage stability of RF system is better than 0.1% and phase stability is better than 0.03°. The hardware design of the LLRF system will be reviewed in this paper.
Olcott, Peter; Kim, Ealgoo; Hong, Keyjo; Lee, Brian J; Grant, Alexander M; Chang, Chen-Ming; Glover, Gary; Levin, Craig S
2015-05-07
The simultaneous acquisition of PET and MRI data shows promise to provide powerful capabilities to study disease processes in human subjects, guide the development of novel treatments, and monitor therapy response and disease progression. A brain-size PET detector ring insert for an MRI system is being developed that, if successful, can be inserted into any existing MRI system to enable simultaneous PET and MRI images of the brain to be acquired without mutual interference. The PET insert uses electro-optical coupling to relay all the signals from the PET detectors out of the MRI system using analog modulated lasers coupled to fiber optics. Because the fibers use light instead of electrical signals, the PET detector can be electrically decoupled from the MRI making it partially transmissive to the RF field of the MRI. The SiPM devices and low power lasers were powered using non-magnetic MRI compatible batteries. Also, the number of laser-fiber channels in the system was reduced using techniques adapted from the field of compressed sensing. Using the fact that incoming PET data is sparse in time and space, electronic circuits implementing constant weight codes uniquely encode the detector signals in order to reduce the number of electro-optical readout channels by 8-fold. Two out of a total of sixteen electro-optical detector modules have been built and tested with the entire RF-shielded detector gantry for the PET ring insert. The two detectors have been tested outside and inside of a 3T MRI system to study mutual interference effects and simultaneous performance with MRI. Preliminary results show that the PET insert is feasible for high resolution simultaneous PET/MRI imaging for applications in the brain.
NASA Astrophysics Data System (ADS)
Olcott, Peter; Kim, Ealgoo; Hong, Keyjo; Lee, Brian J.; Grant, Alexander M.; Chang, Chen-Ming; Glover, Gary; Levin, Craig S.
2015-05-01
The simultaneous acquisition of PET and MRI data shows promise to provide powerful capabilities to study disease processes in human subjects, guide the development of novel treatments, and monitor therapy response and disease progression. A brain-size PET detector ring insert for an MRI system is being developed that, if successful, can be inserted into any existing MRI system to enable simultaneous PET and MRI images of the brain to be acquired without mutual interference. The PET insert uses electro-optical coupling to relay all the signals from the PET detectors out of the MRI system using analog modulated lasers coupled to fiber optics. Because the fibers use light instead of electrical signals, the PET detector can be electrically decoupled from the MRI making it partially transmissive to the RF field of the MRI. The SiPM devices and low power lasers were powered using non-magnetic MRI compatible batteries. Also, the number of laser-fiber channels in the system was reduced using techniques adapted from the field of compressed sensing. Using the fact that incoming PET data is sparse in time and space, electronic circuits implementing constant weight codes uniquely encode the detector signals in order to reduce the number of electro-optical readout channels by 8-fold. Two out of a total of sixteen electro-optical detector modules have been built and tested with the entire RF-shielded detector gantry for the PET ring insert. The two detectors have been tested outside and inside of a 3T MRI system to study mutual interference effects and simultaneous performance with MRI. Preliminary results show that the PET insert is feasible for high resolution simultaneous PET/MRI imaging for applications in the brain.
GDF11 Modulates Ca2+-Dependent Smad2/3 Signaling to Prevent Cardiomyocyte Hypertrophy.
Duran, Javier; Troncoso, Mayarling Francisca; Lagos, Daniel; Ramos, Sebastian; Marin, Gabriel; Estrada, Manuel
2018-05-18
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-β family, has been shown to act as a negative regulator in cardiac hypertrophy. Ca 2+ signaling modulates cardiomyocyte growth; however, the role of Ca 2+ -dependent mechanisms in mediating the effects of GDF11 remains elusive. Here, we found that GDF11 induced intracellular Ca 2+ increases in neonatal rat cardiomyocytes and that this response was blocked by chelating the intracellular Ca 2+ with BAPTA-AM or by pretreatment with inhibitors of the inositol 1,4,5-trisphosphate (IP₃) pathway. Moreover, GDF11 increased the phosphorylation levels and luciferase activity of Smad2/3 in a concentration-dependent manner, and the inhibition of IP₃-dependent Ca 2+ release abolished GDF11-induced Smad2/3 activity. To assess whether GDF11 exerted antihypertrophic effects by modulating Ca 2+ signaling, cardiomyocytes were exposed to hypertrophic agents (100 nM testosterone or 50 μM phenylephrine) for 24 h. Both treatments increased cardiomyocyte size and [³H]-leucine incorporation, and these responses were significantly blunted by pretreatment with GDF11 over 24 h. Moreover, downregulation of Smad2 and Smad3 with siRNA was accompanied by inhibition of the antihypertrophic effects of GDF11. These results suggest that GDF11 modulates Ca 2+ signaling and the Smad2/3 pathway to prevent cardiomyocyte hypertrophy.
Pregnant women models analyzed for RF exposure and temperature increase in 3T RF shimmed birdcages.
Murbach, Manuel; Neufeld, Esra; Samaras, Theodoros; Córcoles, Juan; Robb, Fraser J; Kainz, Wolfgang; Kuster, Niels
2017-05-01
MRI is increasingly used to scan pregnant patients. We investigated the effect of 3 Tesla (T) two-port radiofrequency (RF) shimming in anatomical pregnant women models. RF shimming improves B 1 + uniformity, but may at the same time significantly alter the induced current distribution and result in large changes in both the level and location of the absorbed RF energy. In this study, we evaluated the electrothermal exposure of pregnant women in the third, seventh, and ninth month of gestation at various imaging landmarks in RF body coils, including modes with RF shimming. Although RF shimmed configurations may lower the local RF exposure for the mother, they can increase the thermal load on the fetus. In worst-case configurations, whole-body exposure and local peak temperatures-up to 40.8°C-are equal in fetus and mother. Two-port RF shimming can significantly increase the fetal exposure in pregnant women, requiring further research to derive a very robust safety management. For the time being, restriction to the CP mode, which reduces fetal SAR exposure compared with linear-horizontal polarization modes, may be advisable. Results from this study do not support scanning pregnant patients above the normal operating mode. Magn Reson Med 77:2048-2056, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Oehmigen, Mark, E-mail: mark.oehmigen@uni-due.de
Purpose: This study aims to develop, implement, and evaluate a 16-channel radiofrequency (RF) coil for integrated positron emission tomography/magnetic resonance (PET/MR) imaging of breast cancer. The RF coil is designed for optimized MR imaging performance and PET transparency and attenuation correction (AC) is applied for accurate PET quantification. Methods: A 16-channel breast array RF coil was designed for integrated PET/MR hybrid imaging of breast cancer lesions. The RF coil features a lightweight rigid design and is positioned with a spacer at a defined position on the patient table of an integrated PET/MR system. Attenuation correction is performed by generating andmore » applying a dedicated 3D CT-based template attenuation map. Reposition accuracy of the RF coil on the system patient table while using the positioning frame was tested in repeated measurements using MR-visible markers. The MR, PET, and PET/MR imaging performances were systematically evaluated using modular breast phantoms. Attenuation correction of the RF coil was evaluated with difference measurements of the active breast phantoms filled with radiotracer in the PET detector with and without the RF coil in place, serving as a standard of reference measurement. The overall PET/MR imaging performance and PET quantification accuracy of the new 16-channel RF coil and its AC were then evaluated in first clinical examinations on ten patients with local breast cancer. Results: The RF breast array coil provides excellent signal-to-noise ratio and signal homogeneity across the volume of the breast phantoms in MR imaging and visualizes small structures in the phantoms down to 0.4 mm in plane. Difference measurements with PET revealed a global loss and thus attenuation of counts by 13% (mean value across the whole phantom volume) when the RF coil is placed in the PET detector. Local attenuation ranging from 0% in the middle of the phantoms up to 24% was detected in the peripheral regions of the
Hoersch, Sebastian; Jensen, Morten B.; Kawli, Trupti; Kennedy, Lisa M.; Chavez, Violeta; Tan, Man-Wah; Lieb, Jason D.; Grishok, Alla
2011-01-01
Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studying the biological functions of the endogenous RNA interference factor RDE-4 and conserved PHD zinc finger protein ZFP-1 (AF10), which regulate overlapping sets of genes in Caenorhabditis elegans, we identified an important role for these factors in the negative modulation of transcription of the insulin/PI3 signaling-dependent kinase PDK-1. Consistently, increased expression of pdk-1 in zfp-1 and rde-4 mutants contributed to their reduced lifespan and sensitivity to oxidative stress and pathogens due to the reduction in the expression of DAF-16 and SKN-1 targets. We found that the function of ZFP-1 in modulating pdk-1 transcription was important for the extended lifespan of the age-1(hx546) reduction-of-function PI3 kinase mutant, since the lifespan of the age-1; zfp-1 double mutant strain was significantly shorter compared to age-1(hx546). We further demonstrate that overexpression of ZFP-1 caused an increased resistance to oxidative stress in a DAF-16–dependent manner. Our findings suggest that epigenetic regulation of key upstream signaling components in signal transduction pathways through chromatin and RNAi may have a large impact on the outcome of signaling and expression of numerous downstream genes. PMID:21980302
Mansisidor, Andres R; Cecere, Germano; Hoersch, Sebastian; Jensen, Morten B; Kawli, Trupti; Kennedy, Lisa M; Chavez, Violeta; Tan, Man-Wah; Lieb, Jason D; Grishok, Alla
2011-09-01
Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studying the biological functions of the endogenous RNA interference factor RDE-4 and conserved PHD zinc finger protein ZFP-1 (AF10), which regulate overlapping sets of genes in Caenorhabditis elegans, we identified an important role for these factors in the negative modulation of transcription of the insulin/PI3 signaling-dependent kinase PDK-1. Consistently, increased expression of pdk-1 in zfp-1 and rde-4 mutants contributed to their reduced lifespan and sensitivity to oxidative stress and pathogens due to the reduction in the expression of DAF-16 and SKN-1 targets. We found that the function of ZFP-1 in modulating pdk-1 transcription was important for the extended lifespan of the age-1(hx546) reduction-of-function PI3 kinase mutant, since the lifespan of the age-1; zfp-1 double mutant strain was significantly shorter compared to age-1(hx546). We further demonstrate that overexpression of ZFP-1 caused an increased resistance to oxidative stress in a DAF-16-dependent manner. Our findings suggest that epigenetic regulation of key upstream signaling components in signal transduction pathways through chromatin and RNAi may have a large impact on the outcome of signaling and expression of numerous downstream genes.