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Sample records for rhenium 185 target

  1. Bench to bedside development of GMP grade Rhenium-188-HEDP, a radiopharmaceutical for targeted treatment of painful bone metastases.

    PubMed

    ter Heine, Rob; Lange, Rogier; Breukels, Oscar B; Bloemendal, Haiko J; Rummenie, Rob G; Wakker, Antoinette M; de Graaf, Hilly; Beekman, Freek J; van der Westerlaken, Monique M L; Malingré, Mirte M; Wielders, Jos P M; van den Berg, Leo; Hendrikse, N Harry; de Klerk, John M H

    2014-04-25

    Bone-targeting therapeutic radiopharmaceuticals are effective agents for treatment of painful bone metastases. Rhenium-188-HEDP is such a therapeutic radiopharmaceutical and has advantages over commercially available alternatives in terms of efficacy, safety and the ability to be produced on-site, allowing rapid treatment upon presentation of patients with pain. Unlike many other radiopharmaceuticals, there are no standardized preparation methods for Rhenium-188-HEDP. It is known, however, that drug composition may not only affect stability of the final drug product, but it may also influence bone affinity and, thus, efficacy. Furthermore, for support of clinical studies with Rhenium-188-HEDP as an investigational medicinal product, preparation of this radiopharmaceutical has to be performed under GMP conditions. To our knowledge, no group has reported on the preparation of Rhenium-188-HEDP under GMP conditions or on stock production of sterile non-radioactive starting materials. We present the production of GMP grade Rhenium-188-HEDP for application of this therapeutic radiopharmaceutical in routine clinical practice and for support of clinical studies. In addition, bio-distribution data of Rhenium-188-HEDP in mice and in patients with bone metastases originating from prostate cancer are presented.

  2. Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia

    PubMed Central

    Forstner, Andreas J.; Basmanav, F. Buket; Mattheisen, Manuel; Böhmer, Anne C.; Hollegaard, Mads V.; Janson, Esther; Strengman, Eric; Priebe, Lutz; Degenhardt, Franziska; Hoffmann, Per; Herms, Stefan; Maier, Wolfgang; Mössner, Rainald; Rujescu, Dan; Ophoff, Roel A.; Moebus, Susanne; Mortensen, Preben B.; Børglum, Anders D.; Hougaard, David M.; Frank, Josef; Witt, Stephanie H.; Rietschel, Marcella; Zimmer, Andreas; Nöthen, Markus M.; Miró, Xavier; Cichon, Sven

    2014-01-01

    Background Schizophrenia is a complex neuropsychiatric disorder of unclear etiology. The strongest known genetic risk factor is the 22q11.2 microdeletion. Research has yet to confirm which genes within the deletion region are implicated in schizophrenia. The minimal 1.5 megabase deletion contains MIR185, which encodes microRNA 185. Methods We determined miR-185 expression in embryonic and adult mouse brains. Common and rare variants at this locus were then investigated using a human genetics approach. First, we performed gene-based analyses for MIR185 common variants and target genes using Psychiatric Genomics Consortium genome-wide association data. Second, MIR185 was resequenced in German patients (n = 1000) and controls (n = 500). We followed up promising variants by genotyping an additional European sample (patients, n = 3598; controls, n = 4082). Results In situ hybridization in mice revealed miR-185 expression in brain regions implicated in schizophrenia. Gene-based tests revealed association between common variants in 3 MIR185 target genes (ATAT1, SH3PXD2A, NTRK3) and schizophrenia. Further analyses in mice revealed overlapping expression patterns for these target genes and miR-185. Resequencing identified 2 rare patient-specific novel variants flanking MIR185. However, follow-up genotyping provided no further evidence of their involvement in schizophrenia. Limitations Power to detect rare variant associations was limited. Conclusion Human genetic analyses generated no evidence of the involvement of MIR185 in schizophrenia. However, the expression patterns of miR-185 and its target genes in mice, and the genetic association results for the 3 target genes, suggest that further research into the involvement of miR-185 and its downstream pathways in schizophrenia is warranted. PMID:24936775

  3. Rhenium Redefined

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Through a Small Business Innovation Research (SBIR) contract with NASA's Glenn Research Center, Rhenium Alloys, Inc., of Elyria, Ohio, developed a new method for producing rhenium combustion chambers. Using room temperature isostatic pressing, Rhenium Alloys, Inc., compacted rhenium powder to a high density and into the approximated end shape and dimension of the rocket thruster. The item was then subjected to sintering and containerless hot isostatic pressing, increasing the density of the powder metallurgy part. With the new manufacturing process, both production time and costs are reduced while quality is significantly increased. The method enabled the company to deliver two chemical rocket thrusters to Glenn Research Center. The company makes rhenium a practical choice in manufacturing fields, including the aerospace, nuclear, and electronic industries, with upcoming opportunities projected in medical instrumentation.

  4. High Resolution Laser Spectroscopy of Rhenium Carbide

    NASA Astrophysics Data System (ADS)

    Adam, Allan G.; Hall, Ryan M.; Linton, Colan; Tokaryk, Dennis

    2014-06-01

    The first spectroscopic study of rhenium carbide, ReC, has been performed using both low and high resolution techniques to collect rotationally resolved electronic spectra from 420 to 500nm. Laser-induced fluorescence (LIF), and dispersed fluorescence (DF) techniques were employed. ReC was formed in our laser ablation molecular jet apparatus by ablating a rhenium target rod in the presence of 1% methane in helium. The low resolution spectrum identified four bands of an electronic system belonging to ReC, three of which have been studied so far. Extensive hyperfine structure composed of six hyperfine components was observed in the high resolution spectrum, as well as a clear distinction between the 187ReC and 185ReC isotopologues. The data seems consistent with a ^4Π - ^4Σ- transition, as was predicted before experimentation. Dispersed fluorescence spectra allowed us to determine the ground state vibrational frequency (ωe"=994.4 ± 0.3 wn), and to identify a low-lying electronically excited state at Te"=1118.4 ± 0.4 wn with a vibrational frequency of ωe"=984 ± 2 wn. Personal communication, F. Grein, University of New Brunswick

  5. Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.

    PubMed

    Belkaya, Serkan; Murray, Sean E; Eitson, Jennifer L; de la Morena, M Teresa; Forman, James A; van Oers, Nicolai S C

    2013-10-18

    miR-185 is a microRNA (miR) that targets Bruton's tyrosine kinase in B cells, with reductions in miR-185 linked to B cell autoantibody production. In hippocampal neurons, miR-185 targets both sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and a novel Golgi inhibitor. This miR is haploinsufficient in 90-95% of individuals with chromosome 22q11.2 deletion syndrome, patients who can present with immune, cardiac, and parathyroid problems, learning disorders, and a high incidence of schizophrenia in adults. The reduced levels of miR-185 in neurons cause presynaptic neurotransmitter release. Many of the 22q11.2 deletion syndrome patients have a thymic hypoplasia, which results in a peripheral T cell lymphopenia and unusual T helper cell skewing. The molecular targets of miR-185 in thymocytes are unknown. Using an miR-185 T cell transgenic approach, increasing levels of miR-185 attenuated T cell development at the T cell receptor β (TCRβ) selection checkpoint and during positive selection. This caused a peripheral T cell lymphopenia. Mzb1, Nfatc3, and Camk4 were identified as novel miR-185 targets. Elevations in miR-185 enhanced TCR-dependent intracellular calcium levels, whereas a knockdown of miR-185 diminished these calcium responses. These effects concur with reductions in Mzb1, an endoplasmic reticulum calcium regulator. Consistent with their haploinsufficiency of miR-185, Mzb1 levels were elevated in thymocyte extracts from several 22q11.2 deletion syndrome patients. Our findings indicate that miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1. PMID:24014023

  6. A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction.

    PubMed

    Ye, Rui-Rong; Tan, Cai-Ping; Lin, Yan-Nan; Ji, Liang-Nian; Mao, Zong-Wan

    2015-05-14

    In this report, we designed a histone deacetylase-targeted phosphorescent Re(I) complex ReLMito. Colocalization studies suggested that ReLMito could specially localize to mitochondria. We also demonstrated that ReLMito could induce paraptosis in cancer cells. These features endowed the complex with potential to induce and monitor mitochondrial morphological changes during the paraptosis simultaneously.

  7. MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma

    PubMed Central

    2011-01-01

    Background Perturbation of DNA methylation is frequent in cancers and has emerged as an important mechanism involved in tumorigenesis. To determine how DNA methylation is modified in the genome of primary glioma, we used Methyl-DNA immunoprecipitation (MeDIP) and Nimblegen CpG promoter microarrays to identify differentially DNA methylation sequences between primary glioma and normal brain tissue samples. Methods MeDIP-chip technology was used to investigate the whole-genome differential methylation patterns in glioma and normal brain tissues. Subsequently, the promoter methylation status of eight candidate genes was validated in 40 glioma samples and 4 cell lines by Sequenom's MassARRAY system. Then, the epigenetically regulated expression of these genes and the potential mechanisms were examined by chromatin immunoprecipitation and quantitative real-time PCR. Results A total of 524 hypermethylated and 104 hypomethylated regions were identified in glioma. Among them, 216 hypermethylated and 60 hypomethylated regions were mapped to the promoters of known genes related to a variety of important cellular processes. Eight promoter-hypermethylated genes (ANKDD1A, GAD1, HIST1H3E, PCDHA8, PCDHA13, PHOX2B, SIX3, and SST) were confirmed in primary glioma and cell lines. Aberrant promoter methylation and changed histone modifications were associated with their reduced expression in glioma. In addition, we found loss of heterozygosity (LOH) at the miR-185 locus located in the 22q11.2 in glioma and induction of miR-185 over-expression reduced global DNA methylation and induced the expression of the promoter-hypermethylated genes in glioma cells by directly targeting the DNA methyltransferases 1. Conclusion These comprehensive data may provide new insights into the epigenetic pathogenesis of human gliomas. PMID:21962230

  8. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).

    PubMed

    El Khouri, Elma; Le Pavec, Gwenaëlle; Toledano, Michel B; Delaunay-Moisan, Agnès

    2013-10-25

    In the endoplasmic reticulum (ER), misfolded or improperly assembled proteins are exported to the cytoplasm and degraded by the ubiquitin-proteasome pathway through a process called ER-associated degradation (ERAD). ER-associated E3 ligases, which coordinate substrate recognition, export, and proteasome targeting, are key components of ERAD. Cystic fibrosis transmembrane conductance regulator (CFTR) is one ERAD substrate targeted to co-translational degradation by the E3 ligase RNF5/RMA1. RNF185 is a RING domain-containing polypeptide homologous to RNF5. We show that RNF185 controls the stability of CFTR and of the CFTRΔF508 mutant in a RING- and proteasome-dependent manner but does not control that of other classical ERAD model substrates. Reciprocally, its silencing stabilizes CFTR proteins. Turnover analyses indicate that, as RNF5, RNF185 targets CFTR to co-translational degradation. Importantly, however, simultaneous depletion of RNF5 and RNF185 profoundly blocks CFTRΔF508 degradation not only during translation but also after synthesis is complete. Our data thus identify RNF185 and RNF5 as a novel E3 ligase module that is central to the control of CFTR degradation.

  9. Rhenium material properties

    SciTech Connect

    Biaglow, J.A.

    1995-09-01

    Tensile data were obtained from four different types of rhenium at ambient and elevated temperatures. The four types of rhenium included chemical vapor deposition (CVD) and three powder metallurgy (PM) types, i.e., rolled sheet and pressed and sintered bars, with and without hot isostatic pressure (HIP) treatment. Results revealed a wide range of values with ultimate strengths at ambient temperatures varying from 663 MPa for CVD rhenium to 943 MPa for rolled sheet. A similar spread was also obtained for material tested at 1088 K and 1644 K. The wide variance observed with the different materials indicated that the rhenium manufacturing process, material composition and prior handling strongly dictated its properties. In addition to tensile properties, CVD, pressed and sintered material and HIP rhenium successfully completed 100 cycles of low cycle fatigue. Creep data were also obtained showing that CVD and pressed and sintered rhenium could sustain five hours of testing under a tension of 27.5 MPa at 1922 K.

  10. Rhenium material properties

    NASA Technical Reports Server (NTRS)

    Biaglow, James A.

    1995-01-01

    Tensile data were obtained from four different types of rhenium at ambient and elevated temperatures. The four types of rhenium included chemical vapor deposition (CVD) and three powder metallurgy (PM) types, i.e., rolled sheet and pressed and sintered bars, with and without hot isostatic pressure (HIP) treatment. Results revealed a wide range of values with ultimate strengths at ambient temperatures varying from 663 MPa for CVD rhenium to 943 MPa for rolled sheet. A similar spread was also obtained for material tested at 1088 K and 1644 K. The wide variance observed with the different materials indicated that the rhenium manufacturing process, material composition and prior handling strongly dictated its properties. In addition to tensile properties, CVD, pressed and sintered material and HIP rhenium successfully completed 100 cycles of low cycle fatigue. Creep data were also obtained showing that CVD and pressed and sintered rhenium could sustain five hours of testing under a tension of 27.5 MPa at 1922 K.

  11. Rhenium-Foil Witness Cylinders

    NASA Technical Reports Server (NTRS)

    Knight, B. L.

    1992-01-01

    Cylindrical portion of wall of combustion chamber replaced with rhenium foil mounted on holder. Rhenium oxidizes without melting, indicating regions of excess oxidizer in combustion-chamber flow. Rhenium witness foils also useful in detecting excess oxygen and other oxidizers at temperatures between 2,000 and 3,600 degrees F in burner cores of advanced gas-turbine engines.

  12. Rhenium Rocket Manufacturing Technology

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The NASA Lewis Research Center's On-Board Propulsion Branch has a research and technology program to develop high-temperature (2200 C), iridium-coated rhenium rocket chamber materials for radiation-cooled rockets in satellite propulsion systems. Although successful material demonstrations have gained much industry interest, acceptance of the technology has been hindered by a lack of demonstrated joining technologies and a sparse materials property data base. To alleviate these concerns, we fabricated rhenium to C-103 alloy joints by three methods: explosive bonding, diffusion bonding, and brazing. The joints were tested by simulating their incorporation into a structure by welding and by simulating high-temperature operation. Test results show that the shear strength of the joints degrades with welding and elevated temperature operation but that it is adequate for the application. Rhenium is known to form brittle intermetallics with a number of elements, and this phenomena is suspected to cause the strength degradation. Further bonding tests with a tantalum diffusion barrier between the rhenium and C-103 is planned to prevent the formation of brittle intermetallics.

  13. Rhenium and technetium tricarbonyl complexes of 1,4-Substituted pyridyl-1,2,3-triazole bidentate 'click' ligands conjugated to a targeting RGD peptide.

    PubMed

    Connell, Timothy U; Hayne, David J; Ackermann, Uwe; Tochon-Danguy, Henri J; White, Jonathan M; Donnelly, Paul S

    2014-04-01

    New 1,4-substituted pyridyl-1,2,3-triazole ligands with pendent phenyl isothiocyanate functional groups linked to the heterocycle through a short methylene or longer polyethylene glycol spacers were prepared and conjugated to a peptide containing the arginine-glycine-aspartic acid peptide motif. Rhenium and technetium carbonyl complexes, [M(CO)3 L(x) (py)](+) (where M = Re(I) or (99m) Tc(I) ; L(x)  = 1,4-substituted pyridyl-1,2,3-triazole ligands and py = pyridine) were prepared. One rhenium complex has been characterized by X-ray crystallography, and the luminescent properties of [M(CO)3 L(x) (py)](+) are reported.

  14. Mineral of the month: rhenium

    USGS Publications Warehouse

    Magyar, Michael J.

    2005-01-01

    Rhenium, an exotic, heat-resistant metal, has grown in importance since its discovery nearly 80 years ago. First isolated by a team of German chemists studying a platinum ore, the mineral was named for the Rhine River. From then until the 1960s, only 2 metric tons of rhenium were produced worldwide. In 2004, worldwide production was 40 metric tons.

  15. Low blank rhenium isotope ratio determinations by V2O5 coated nickel filaments using negative thermal ionization mass spectrometry

    NASA Astrophysics Data System (ADS)

    Walczyk, Thomas; Hebeda, Erhard H.; Heumann, Klaus G.

    1994-02-01

    Thenium isotope ratio determinations are, in principle, possible by negative thermal ionization mass spectrometry (NTI-MS). Relatively high rhenium blanks from the commonly-used filament materials prevent accurate isotope ratio determinations, especially for small rhenium sample amounts which are of importance, for example, in geochronology in connection with the Re/Os dating method. Platinum and nickel filaments were tested by different preparation techniques to reduce the rhenium blank contribution from the filament material. The lowest rhenium blank of less than 1 pg was achieved by coating nickel filaments with V2O5 prior to degassing under high vacuum conditions at 850°C. Obviously, the vanadium--nickel oxide layer formed on the surface of the filament during this process prevents further emission of rhenium ions from the filament material. Using Ba(OH)2 for the enhancement of negative thermal ions, 1 ng of rhenium resulted in ion currents at the detector side of about 10-11 A with an ionization efficiency of up to 20%. The 185Re/187Re isotope ratio of a sample of natural isotopic composition could be determined to be 0.59818 ± 0.00026 with a relative precision of 0.04%. The isotope ratio determination for an 187Re spike was comparable in precision but the relative standard deviation of an 185Re spike was significantly higher, which could be explained by mass fractionations of oxygen in the measured ReO-4 ion. The ReO-4 ion is about 200 to 2500 times more abundant than the only other detectable rhenium ion in NTI-MSReO-3. The ReO-4/ReO-4 ratio decreases with increasing temperature. By the low blank NTI-MS technique described in this work, more precise and accurate determinations of the rhenium isotope ratio and the rhenium concentration by isotope dilution analysis from nanogramme samples are possible.

  16. Oxide strengthened molybdenum-rhenium alloy

    DOEpatents

    Bianco, Robert; Buckman, Jr., R. William

    2000-01-01

    Provided is a method of making an ODS molybdenum-rhenium alloy which includes the steps of: (a) forming a slurry containing molybdenum oxide and a metal salt dispersed in an aqueous medium, the metal salt being selected from nitrates or acetates of lanthanum, cerium or thorium; (b) heating the slurry in the presence of hydrogen to form a molybdenum powder comprising molybdenum and an oxide of the metal salt; (c) mixing rhenium powder with the molybdenum powder to form a molybdenum-rhenium powder; (d) pressing the molybdenum-rhenium powder to form a molybdenum-rhenium compact; (e) sintering the molybdenum-rhenium compact in hydrogen or under a vacuum to form a molybdenum-rhenium ingot; and (f) compacting the molybdenum-rhenium ingot to reduce the cross-sectional area of the molybdenum-rhenium ingot and form a molybdenum-rhenium alloy containing said metal oxide. The present invention also provides an ODS molybdenum-rhenium alloy made by the method. A preferred Mo--Re-ODS alloy contains 7-14 weight % rhenium and 2-4 volume % lanthanum oxide.

  17. Evaluation of Rhenium Joining Methods

    NASA Technical Reports Server (NTRS)

    Reed, Brian D.; Morren, Sybil H.

    1995-01-01

    Coupons of rhenium-to-Cl03 flat plate joints, formed by explosive and diffusion bonding, were evaluated in a series of shear tests. Shear testing was conducted on as-received, thermally-cycled (100 cycles, from 21 to 1100 C), and thermally-aged (3 and 6 hrs at 1100 C) joint coupons. Shear tests were also conducted on joint coupons with rhenium and/or Cl03 electron beam welded tabs to simulate the joint's incorporation into a structure. Ultimate shear strength was used as a figure of merit to assess the effects of the thermal treatment and the electron beam welding of tabs on the joint coupons. All of the coupons survived thermal testing intact and without any visible degradation. Two different lots of as-received, explosively-bonded joint coupons had ultimate shear strengths of 281 and 310 MPa and 162 and 223 MPa, respectively. As-received, diffusion-bonded coupons had ultimate shear strengths of 199 and 348 MPa. For the most part, the thermally-treated and rhenium weld tab coupons had shear strengths slightly reduced or within the range of the as-received values. Coupons with Cl03 weld tabs experienced a significant reduction in shear strength. The degradation of strength appeared to be the result of a poor heat sink provided during the electron beam welding. The Cl03 base material could not dissipate heat as effectively as rhenium, leading to the formation of a brittle rhenium-niobium intermetallic.

  18. Improved Rhenium Thrust Chambers

    NASA Technical Reports Server (NTRS)

    O'Dell, John Scott

    2015-01-01

    Radiation-cooled bipropellant thrust chambers are being considered for ascent/ descent engines and reaction control systems on various NASA missions and spacecraft, such as the Mars Sample Return and Orion Multi-Purpose Crew Vehicle (MPCV). Currently, iridium (Ir)-lined rhenium (Re) combustion chambers are the state of the art for in-space engines. NASA's Advanced Materials Bipropellant Rocket (AMBR) engine, a 150-lbf Ir-Re chamber produced by Plasma Processes and Aerojet Rocketdyne, recently set a hydrazine specific impulse record of 333.5 seconds. To withstand the high loads during terrestrial launch, Re chambers with improved mechanical properties are needed. Recent electrochemical forming (EL-Form"TM") results have shown considerable promise for improving Re's mechanical properties by producing a multilayered deposit composed of a tailored microstructure (i.e., Engineered Re). The Engineered Re processing techniques were optimized, and detailed characterization and mechanical properties tests were performed. The most promising techniques were selected and used to produce an Engineered Re AMBR-sized combustion chamber for testing at Aerojet Rocketdyne.

  19. Plasma miR-185 is decreased in patients with esophageal squamous cell carcinoma and might suppress tumor migration and invasion by targeting RAGE.

    PubMed

    Jing, Rongrong; Chen, Wen; Wang, Huimin; Ju, Shaoqing; Cong, Hui; Sun, Baolan; Jin, Qin; Chu, Shaopeng; Xu, Lili; Cui, Ming

    2015-11-01

    The receptor for advanced-glycation end products (RAGE) is upregulated in various cancers and has been associated with tumor progression, but little is known about its expression and regulation by microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC). Here, we describe miR-185, which represses RAGE expression, and investigate the biological role of miR-185 in ESCC. In this study, we found that the high level of RAGE expression in 29 pairs of paraffin-embedded ESCC tissues was correlated positively with the depth of invasion by immunohistochemistry, suggesting that RAGE was involved in ESCC. We used bioinformatics searches and luciferase reporter assays to investigate the prediction that RAGE was regulated directly by miR-185. Besides, overexpression of miR-185 in ESCC cells was accompanied by 27% (TE-11) and 49% (Eca-109) reduced RAGE expression. The effect was further confirmed in RAGE protein by immunofluorescence in both cell lines. The effects were reversed following cotransfection with miR-185 and high-level expression of the RAGE vector. Furthermore, the biological role of miR-185 in ESCC cell lines was investigated using assays of cell viability, Ki-67 staining, and cell migration and invasion, as well as in a xenograft model. We found that overexpression of miR-185 inhibited migration and invasion by ESCC cells in vitro and reduced their capacity to develop distal pulmonary metastases in vivo partly through the RAGE/heat shock protein 27 pathway. Interestingly, in clinical specimens, the level of plasma miR-185 expression was decreased significantly (P = 0.002) in patients with ESCC [0.500; 95% confidence interval (CI) 0.248-1.676] compared with healthy controls (2.410; 95% CI 0.612-5.671). The value of the area under the receiver-operating characteristic curve was 0.73 (95% CI 0.604-0.855). In conclusion, our findings shed novel light on the role of miR-185/RAGE in ESCC metastasis, and plasma miR-185 has potential as a novel diagnostic biomarker

  20. The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals.

    PubMed

    Donnelly, Paul S

    2011-02-01

    There are several isotopes of copper and rhenium that are of interest in the development of new molecular imaging or radiotherapeutic agents. This perspective article highlights the role of coordination chemistry in the design of copper and rhenium radiopharmaceuticals engineered to selectively target tissue of interest such as cancer cells or pathological features associated with Alzheimer's disease. The coordination chemistry of copper bis(thiosemicarbazone) derivatives and copper macrocyclic complexes is discussed in terms of their potential application as targeted positron emission tomography tracers for non-invasive diagnostic imaging. A range of rhenium complexes with different ligands with rhenium in different oxidation states are introduced and their potential to be translated to new radiotherapeutic agents discussed.

  1. Oxide strengthened molybdenum-rhenium alloy

    SciTech Connect

    Bianco, Robert; Buckman, William R. Jr.

    1998-12-01

    Provided is a method of making an ODS molybdenum-rhenium alloy which includes the steps of: (1) forming a slurry containing molybdenum oxide and a metal salt dispersed in an aqueous medium, the metal salt being selected from nitrates or acetates of lanthanum, cerium or thorium; (2) heating the slurry in the presence of hydrogen to form a molybdenum powder comprising molybdenum and an oxide of the metal salt; (3) mixing rhenium powder with the molybdenum powder to form a molybdenum-rhenium powder; (4) pressing the molybdenum-rhenium powder to form a molybdenum-rhenium compact; (5) sintering the molybdenum-rhenium compact in hydrogen or under a vacuum to form a molybdenum-rhenium ingot; and (6) compacting the molybdenum-rhenium ingot to reduce the cross-sectional area of the molybdenum-rhenium ingot and form a molybdenum-rhenium alloy containing said metal oxide. The present invention also provides an ODS molybdenum-rhenium alloy made by the method.

  2. Directed light fabrication of rhenium components

    SciTech Connect

    Milewski, J.O.; Thoma, D.J.; Lewis, G.K.

    1997-02-01

    Directed Light Fabrication (DLF) is a direct metal deposition process that fuses powder, delivered by gas into the focal zone of a high powered laser beam to form fully dense near-net shaped components. This is accomplished in one step without the use of molds, dies, forming, pressing, sintering or forging equipment. DLF is performed in a high purity inert environment free from the contaminants associated with conventional processing such as oxide and carbon pickup, lubricants, binding agents, cooling or cleaning agents. Applications using rhenium have historically been limited in part by its workability and cost. This study demonstrates the ability to fuse rhenium metal powder, using a DLF machine, into free standing rods and describes the associated parameter study. Microstructural comparisons between DLF deposited rhenium and commercial rhenium sheet product is performed. This research combined with existing DLF technology demonstrates the feasibility of forming complex rhenium, metal shapes directly from powder.

  3. Structure of rhenium-containing sodium borosilicate glass

    SciTech Connect

    Goel, Ashutosh; McCloy, John S.; Windisch, Charles F.; Riley, Brian J.; Schweiger, Michael J.; Rodriguez, Carmen P.; Ferreira, Jose M.

    2013-03-01

    A series of sodium borosilicate glasses were synthesized with increasing fractions of KReO4 or Re2O7, to 10000 ppm (1 mass%) target Re in glass, to assess the effects of large concentrations of rhenium on glass structure and to estimate the solubility of technetium, a radioactive component in typical low active waste nuclear waste glasses. Magic angle spinning nuclear magnetic resonance (MAS-NMR), Fourier transform infrared (FTIR) spectroscopy, and Raman spectroscopy were performed to characterize the glasses as a function of Re source additions. In general, silicon was found coordinated in a mixture of Q2 and Q3 structural units, while Al was 4-coordinated and B was largely 3-coordinate and partially 4-coordinated. The rhenium source did not appear to have significant effects on the glass structure. Thus, at the up to the concentrations that remain in dissolved in glass, ~3000 ppm Re by mass maximum. , the Re appeared to be neither a glass-former nor a strong glass modifier., Rhenium likely exists in isolated ReO4- anions in the interstices of the glass network, as evidenced by the polarized Raman spectrum of the Re glass in the absence of sulfate. Analogous to SO42-¬ in similar glasses, ReO4- is likely a network modifier and forms alkali salt phases on the surface and in the bulk glass above solubility.

  4. Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum(II) and rhenium(I) with a ligand targeting the translocator protein (TSPO).

    PubMed

    Margiotta, Nicola; Denora, Nunzio; Piccinonna, Sara; Laquintana, Valentino; Lasorsa, Francesco Massimo; Franco, Massimo; Natile, Giovanni

    2014-11-21

    The 18 kDa translocator protein (TSPO) is overexpressed in many types of cancers and is also abundant in activated microglial cells occurring in inflammatory neurodegenerative diseases. The TSPO-selective ligand 2-(8-(2-(bis-(pyridin-2-yl-methyl)amino)acetamido)-2-(4-chlorophenyl)H-imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide (CB256), which fulfills the requirements of a bifunctional chelate approach, has been used to synthesize coordination complexes containing either Pt (1) or Re (3), or both metal ions (2). The new metal complexes showed a cellular uptake markedly greater than that of the precursor metallic compounds and were also able to induce apoptosis in C6 glioma cells. The good cytotoxicity of the free ligand CB256 towards C6, A2780, and A2780cisR tumor cell lines was attenuated after coordination of the dipicolylamine moiety to Pt while coordination of the imidazopyridine residue to Re reduces the affinity towards TSPO. The results of the present investigation are essential for the design of new imidazopyridine bifunctional chelate ligands targeted to TSPO.

  5. Rhenium/Oxygen Interactions at Elevated Temperatures

    NASA Technical Reports Server (NTRS)

    Jacobson, Nathan; Myers, Dwight; Zhu, Dong-Ming; Humphrey, Donald

    2000-01-01

    The oxidation of pure rhenium is examined from 600-1400 C in oxygen/argon mixtures. Linear weight loss kinetics are observed. Gas pressures, flow rates, and temperatures are methodically varied to determine the rate controlling steps. The reaction at 600 and 800 C appears to be controlled by a chemical reaction step at the surface; whereas the higher temperature reactions appear to be controlled by gas phase diffusion of oxygen to the rhenium surface. Attack of the rhenium appears to be along grain boundaries and crystallographic planes.

  6. Rhenium-Oxygen Interactions at High Temperatures

    NASA Technical Reports Server (NTRS)

    Jacobson, Nathan S.; Myers, Dwight L.; Zhu, Dongming; Humphrey, Donald

    2000-01-01

    The reaction of pure rhenium metal with dilute oxygen/argon mixtures was studied from 600 to 1400 C. Temperature, oxygen pressure, and flow rates were systematically varied to determine the rate-controlling steps. At lower temperatures the oxygen/rhenium chemical reaction is rate limiting; at higher temperatures gas-phase diffusion of oxygen through the static boundary layer is rate limiting. At all temperatures post-reaction microstructures indicate preferential attack along certain crystallographic planes and defects.

  7. Mineral resource of the month: rhenium

    USGS Publications Warehouse

    Polyak, Désirée E.

    2012-01-01

    Rhenium, a silvery-white, heat resistant metal, has increased significantly in importance since its discovery in 1925. First isolated by a team of German chemists studying platinum ore, the mineral was named for the Rhine River. From 1925 until the 1960s, only two metric tons of rhenium were produced worldwide. Since then, its uses have steadily increased, including everything from unleaded gasoline to jet engines, and worldwide annual production now tops 45 metric tons.

  8. Recovery of rhenium from sulfuric acid solutions with activated coals

    SciTech Connect

    Troshkina, I.D.; Naing, K.Z.; Ushanova, O.N.; P'o, V.; Abdusalomov, A.A.

    2006-09-15

    Equilibrium and kinetic characteristics of rhenium sorption from sulfuric acid solutions (pH 2) by activated coals produced from coal raw materials (China) were studied. Constants of the Henry equation describing isotherms of rhenium sorption by activated coals were calculated. The effective diffusion coefficients of rhenium in the coals were determined. The dynamic characteristics of rhenium sorption and desorption were determined for the activated coal with the best capacity and kinetic characteristics.

  9. Liquid fluorine/hydrazine rhenium thruster update

    NASA Technical Reports Server (NTRS)

    Appel, M. A.; Kaplan, R. B.; Tuffias, R. H.

    1983-01-01

    The status of a fluorine/hydrazine thruster development program is discussed. A solid rhenium metal sea-level thrust chamber was successfully fabricated and tested for a total run duration of 1075 s with 17 starts. Rhenium fabrication methods are discussed. A test program was conducted to evaluate performance and chamber cooling. Acceptable performance was reached and cooling was adequate. A flight-type injector was fabricated that achieved an average extrapolated performance value of 3608 N-s/kg (368 lbf-s/lbm). Altitude thrust chambers were fabricated. One chamber incorporates a rhenium combustor and nozzle with an area ratio of 15:1, and a columbium nozzle extension with area ratios from 15:1 to 60:1. The other chamber was fabricated completely with a carbon/carbon composite. Because of the attributes of rhenium for use in high-temperature applications, a program to provide the materials and processes technology needed to reliably fabricate and/or repair vapor-deposited rhenium parts of relatively large size and complex shape is recommended.

  10. Rhenium-Based Hydrosols: Preparation and Properties.

    PubMed

    Mucalo, Michael R.; Bullen, Craig R.

    2001-07-01

    Transmission electron microscope (TEM), ultraviolet-visible (UV/vis), electrospray mass spectrometric (ESMS), and X-ray photoelectron spectroscopic (XPS) studies are presented on a little studied rhenium hydrosol system produced by reduction of aqueous K(2)ReCl(6) with hydrazine in the presence or absence of a gum arabic protecting agent. The studies indicate that hydrazine-generated "rhenium hydrosols" are unstable in water and slowly dissolve over time in aqueous media to form the highly stable perrhenate ion. Copyright 2001 Academic Press.

  11. Characterization of Rhenium Oxides Using ESCA

    NASA Technical Reports Server (NTRS)

    Panda, Binayak; Jones, Clyde S. (Technical Monitor)

    2001-01-01

    Rhenium as an engineering material has the following properties: (1) high melting point (one of the refractory metals); (2) high strength at elevated temperatures; (3) excellent toughness at room temperature; (4) low vapor pressure at melting point; (5) low coefficient of thermal expansion; (6) high impact and wear resistance; (7) compatibility with elements such as carbon and platinum; (8) conservation of properties in the presence of hydrogen, water vapor, and nitrogen oxides; and (9) poor oxidation resistance. This viewgraph presentation gives an overview of rhenium oxide characterization, including details on its history, experimental procedure using ESCA, and the analysis of the oxides (spectra and effects of ion sputtering).

  12. Size and shape of rhenium nanoparticles.

    SciTech Connect

    Yang, N.; Mickelson, G. E.; Greenlay, N.; Kelly, S. D.; Vila, F. D.; Kas, J.; Rehr, J. J.; Bare, S. R.; X-Ray Science Division; UOP LLC; EXAFS; Univ. of Washington

    2007-01-01

    In this paper the results from a detailed XAFS characterization of supported rhenium nanoparticles are presented. The Re nanoparticles are formed by the reduction of dispersed supported rhenium oxide in the presence of moist hydrogen. The shape of the wet-reduced Re clusters is determined by comparing the EXAFS spectra of Re-metal to the Re-wet-reduced clusters to 6 {angstrom}. A decrease in the signal from the 4th and 7th Re shells is an indication of sheet-like rather than spherical-like particles.

  13. Size and Shape of Rhenium Nanoparticles

    SciTech Connect

    Yang, N.; Mickelson, G. E.; Greenlay, N.; Bare, Simon R.; Kelly, S. D.; Vila, F. D.; Kas, J.; Rehr, J. J.

    2007-02-02

    In this paper the results from a detailed XAFS characterization of supported rhenium nanoparticles are presented. The Re nanoparticles are formed by the reduction of dispersed supported rhenium oxide in the presence of moist hydrogen. The shape of the wet--reduced Re clusters is determined by comparing the EXAFS spectra of Re-metal to the Re-wet-reduced clusters to 6 A. A decrease in the signal from the 4th and 7th Re shells is an indication of sheet-like rather than spherical-like particles.

  14. Rhenium solubility in borosilicate nuclear waste glass: implications for the processing and immobilization of technetium-99.

    PubMed

    McCloy, John S; Riley, Brian J; Goel, Ashutosh; Liezers, Martin; Schweiger, Michael J; Rodriguez, Carmen P; Hrma, Pavel; Kim, Dong-Sang; Lukens, Wayne W; Kruger, Albert A

    2012-11-20

    The immobilization of technetium-99 ((99)Tc) in a suitable host matrix has proven to be a challenging task for researchers in the nuclear waste community around the world. In this context, the present work reports on the solubility and retention of rhenium, a nonradioactive surrogate for (99)Tc, in a sodium borosilicate glass. Glasses containing target Re concentrations from 0 to 10,000 ppm [by mass, added as KReO(4) (Re(7+))] were synthesized in vacuum-sealed quartz ampules to minimize the loss of Re from volatilization during melting at 1000 °C. The rhenium was found as Re(7+) in all of the glasses as observed by X-ray absorption near-edge structure. The solubility of Re in borosilicate glasses was determined to be ~3000 ppm (by mass) using inductively coupled plasma optical emission spectroscopy. At higher rhenium concentrations, additional rhenium was retained in the glasses as crystalline inclusions of alkali perrhenates detected with X-ray diffraction. Since (99)Tc concentrations in a glass waste form are predicted to be <10 ppm (by mass), these Re results implied that the solubility should not be a limiting factor in processing radioactive wastes, assuming Tc as Tc(7+) and similarities between Re(7+) and Tc(7+) behavior in this glass system.

  15. Iridium-Coated Rhenium Combustion Chamber

    NASA Technical Reports Server (NTRS)

    Schneider, Steven J.; Tuffias, Robert H.; Rosenberg, Sanders D.

    1994-01-01

    Iridium-coated rhenium combustion chamber withstands operating temperatures up to 2,200 degrees C. Chamber designed to replace older silicide-coated combustion chamber in small rocket engine. Modified versions of newer chamber could be designed for use on Earth in gas turbines, ramjets, and scramjets.

  16. Elastic module of superhard rhenium diboride

    SciTech Connect

    Koehler, Michael R.; Keppens, Veerle; Sales, Brian C; Jin, Rongying; Mandrus, David

    2009-01-01

    The elastic moduli of polycrystalline rhenium diboride are measured as a function of temperature between 5 and 325 K. The room temperature results show that ReB{sub 2} has very high values for both the bulk and shear modulus, confirming the incompressible and superhard nature of this material. With decreasing temperature, the moduli increase, with a hint of softening below 50 K.

  17. ITEP MEVVA ion beam for rhenium silicide production

    SciTech Connect

    Kulevoy, T.; Seleznev, D.; Kropachev, G.; Kozlov, A.; Kuibeda, R.; Yakushin, P.; Petrenko, S.; Gerasimenko, N.; Medetov, N.; Zaporozhan, O.

    2010-02-15

    The rhenium silicides are very attractive materials for semiconductor industry. In the Institute for Theoretical and Experimental Physics (ITEP) at the ion source test bench the research program of rhenium silicide production by ion beam implantation are going on. The investigation of silicon wafer after implantation of rhenium ion beam with different energy and with different total dose were carried out by secondary ions mass spectrometry, energy-dispersive x-ray microanalysis, and x-ray diffraction analysis. The first promising results of rhenium silicide film production by high intensity ion beam implantation are presented.

  18. 32 CFR 185.6 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Information requirements. 185.6 Section 185.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE MILITARY SUPPORT TO CIVIL AUTHORITIES (MSCA) § 185.6 Information requirements. The reporting requirements in § 185.5...

  19. 46 CFR 185.420 - Crew training.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Crew training. 185.420 Section 185.420 Shipping COAST...) OPERATIONS Crew Requirements § 185.420 Crew training. (a) The owner, charterer, master or managing operator... duties listed in the station bill required by § 185.514 of this part. (b) Training conducted on a...

  20. Characterization of Rhenium Oxides Using ESCA

    NASA Technical Reports Server (NTRS)

    Panda, Binayak; Gentz, Steven J. (Technical Monitor)

    2001-01-01

    High melting point and inherent ductility (toughness) over a wide range of temperature has made Rhenium an engineering material of choice for several thrust chambers in propulsion systems. Although the material remains tough at high temperatures, it still can readily transform to several oxides. As many as eight different oxides have been reported in literature. When characterized using ESCA (Electron Spectroscopy for Chemical Analyses) these oxides show large shifts in the Re 4f line positions. While this unique property could be used as a tool for oxide characterization, literature indicates that only a few of these oxides have been characterized. Current work focuses on characterizing oxides of Rhenium using ESCA. Spectral line Re 4f have been measured for various oxides and the results have been compared with the Re 4f line positions of real-time oxidation products from space hardware.

  1. Rhenium Mechanical Properties and Joining Technology

    NASA Technical Reports Server (NTRS)

    Reed, Brian D.; Biaglow, James A.

    1996-01-01

    Iridium-coated rhenium (Ir/Re) provides thermal margin for high performance and long life radiation cooled rockets. Two issues that have arisen in the development of flight Ir/Re engines are the sparsity of rhenium (Re) mechanical property data (particularly at high temperatures) required for engineering design, and the inability to directly electron beam weld Re chambers to C103 nozzle skirts. To address these issues, a Re mechanical property database is being established and techniques for creating Re/C103 transition joints are being investigated. This paper discusses the tensile testing results of powder metallurgy Re samples at temperatures from 1370 to 2090 C. Also discussed is the evaluation of Re/C103 transition pieces joined by both, explosive and diffusion bonding. Finally, the evaluation of full size Re transition pieces, joined by inertia welding, as well as explosive and diffusion bonding, is detailed.

  2. Iridium-coated rhenium thrusters by CVD

    NASA Technical Reports Server (NTRS)

    Harding, J. T.; Kazaroff, J. M.; Appel, M. A.

    1989-01-01

    Operation of spacecraft thrusters at increased temperature reduces propellant requirements. Inasmuch as propellant comprises the bulk of a satellite's mass, even a small percentage reduction makes possible a significant enhancement of the mission in terms of increased payload. Because of its excellent high temperature strength, rhenium is often the structural material of choice. It can be fabricated into free-standing shapes by chemical vapor deposition (CVD) onto an expendable mandrel. What rhenium lacks is oxidation resistance, but this can be provided by a coating of iridium, also by CVD. This paper describes the process used by Ultramet to fabricate 22-N (5-lbf) and, more recently, 445-N (100-lbf) Ir/Re thrusters; characterizes the CVD-deposited materials; and summarizes the materials effects of firing these thrusters. Optimal propellant mixture ratios can be employed because the materials withstand an oxidizing environment up to the melting temperature of iridium, 2400 C (4350 F).

  3. Iridium-coated rhenium thrusters by CVD

    NASA Technical Reports Server (NTRS)

    Harding, John T.; Kazaroff, John M.; Appel, Marshall A.

    1988-01-01

    Operation of spacecraft thrusters at increased temperature reduces propellant requirements. Inasmuch as propellant comprises the bulk of a satellite's mass, even a small percentage reduction makes possible a significant enhancement of the mission in terms of increased payload. Because of its excellent high temperature strength, rhenium is often the structural material of choice. It can be fabricated into free-standing shapes by chemical vapor deposition (CVD) onto an expendable mandrel. What rhenium lacks is oxidation resistance, but this can be provided by a coating of iridium, also by CVD. This paper describes the process used by Ultramet to fabricate 22-N (5-lbf) and, more recently, 445-N (100-lbf) Ir/Re thrusters; characterizes the CVD-deposited materials; and summarizes the materials effects of firing these thrusters. Optimal propellant mixture ratios can be employed because the materials withstand an oxidizing environment up to the meltimg temperature of iridium, 2400 C (4350 F).

  4. Rhenium ion beam for implantation into semiconductors

    SciTech Connect

    Kulevoy, T. V.; Seleznev, D. N.; Alyoshin, M. E.; Kraevsky, S. V.; Yakushin, P. E.; Khoroshilov, V. V.; Gerasimenko, N. N.; Smirnov, D. I.; Fedorov, P. A.; Temirov, A. A.

    2012-02-15

    At the ion source test bench in Institute for Theoretical and Experimental Physics the program of ion source development for semiconductor industry is in progress. In framework of the program the Metal Vapor Vacuum Arc ion source for germanium and rhenium ion beam generation was developed and investigated. It was shown that at special conditions of ion beam implantation it is possible to fabricate not only homogenous layers of rhenium silicides solid solutions but also clusters of this compound with properties of quantum dots. At the present moment the compound is very interesting for semiconductor industry, especially for nanoelectronics and nanophotonics, but there is no very developed technology for production of nanostructures (for example quantum sized structures) with required parameters. The results of materials synthesis and exploration are presented.

  5. Rhenium Radioisotopes for Therapeutic Radiopharmaceutical Development

    SciTech Connect

    Beets, A.L.; Knapp, F.F., Jr.; Kropp, J.; Lin, W.-Y.; Pinkert, J.; Wang, S.-Y.

    1999-01-18

    The availability of therapeutic radioisotopes at reasonable costs is important for applications in nuclear medicine, oncology and interventional cardiology, Rhenium-186 (Re-186) and rhenium-1 88 (Re-188) are two reactor-produced radioisotope which are attractive for a variety of therapeutic applications, Rhenium-186 has a half-life of 90 hours and decays with emission of a &particle with a maximum energy of 1.08 MeV and a 135 keV (9Yo) gamma which permits imaging. In contrast, Re- 188 has a much shorter half-life of 16.9 hours and emits a p-particle with a much higher energy of 2.12 MeV (Em=) and a 155 keV gamma photon (15Yo) for imaging. While Re-186 is unavailable from a generator system and must be directly produced in a nuclear reactor, Re-188 can also be directly produced in a reactor with high specific activity, but is more conveniently and cost-effectively available as carrier-free sodium perrhenate by saline elution of the alumina-based tungsten-188 (W1 88)/Re-l 88 generator system [1-2]. Since a comprehensive overviewofRe-186 and Re-188 therapeutic agents is beyond the scope of this &tended Abstrac4 the goal is to provide key examples of various agents currently in clinical use and those which are being developed for important clinical applications.

  6. Rhenium: a rare metal critical in modern transportation

    USGS Publications Warehouse

    John, David A.

    2015-01-01

    Rhenium rarely occurs as a native element or as its own sulfide mineral—rheniite (ReS2)—and often occurs as a substitute for molybdenum in molybdenite (MoS2). Most extracted rhenium is a byproduct of copper mining, with about 80 percent recovered from flue dust during the processing of molybdenite concentrates from porphyry copper deposits.

  7. Cellular uptake and cytotoxicity of octahedral rhenium cluster complexes.

    PubMed

    Choi, Soo-Jin; Brylev, Konstantin A; Xu, Jing-Zhe; Mironov, Yuri V; Fedorov, Vladimir E; Sohn, Youn Soo; Kim, Sung-Jin; Choy, Jin-Ho

    2008-11-01

    Cellular uptake behavior of a novel class of octahedral rhenium cluster compounds, hexahydroxo complexes K(4)[{Re(6)S(8)}(OH)(6)].8H(2)O (1) and K(4)[{Re(6)Se(8)}(OH)(6)].8H(2)O (2), was evaluated in human cervical adenocarcinoma HeLa cells. Confocal microscopy and flow cytometry studies demonstrated that rhenium cluster 1 was not internalized into cell, while rhenium cluster 2 was. Conjugation of a polymer to rhenium cluster 1, namely the derivative K(4)[{Re(6)S(8)}(OH)(5)L] (3) (L is amphiphilic diblock copolymer MPEG550-CH(2)CONH-GlyPheLeuGlyPheLeu-COO(-)), considerably enhanced cellular uptake in a concentration-dependent manner and was predominantly localized in the cytoplasm and nucleus upon incubation time. The uptake of rhenium cluster 2 was mediated by energy-dependent endocytosis, whereas rhenium cluster 3 was directly ingested into cells by cell-fusion-like mechanism. According to the cytotoxicity evaluation test, both rhenium clusters 2 and 3 did not exhibit acute cytotoxic effects up to 50 microM, at the practical concentration level of biological applications. It is, therefore, expected that the rhenium cluster complexes can be promising potential candidates as diagnostic agents for medical treatment.

  8. Near-Net Shape Powder Metallurgy Rhenium Thruster

    NASA Technical Reports Server (NTRS)

    Leonhardt, Todd; Hamister, Mark; Carlen, Jan C.; Biaglow, James; Reed, Brian

    2001-01-01

    This paper describes the development of a method to produce a near-net shape (NNS) powder metallurgy (PM) rhenium combustion chamber of the size 445 N (100 lbf) used in a high performance liquid apogee engine. These engines are used in low earth Orbit and geostationary orbit for satellite positioning systems. The developments in near-net shape powder metallurgy rhenium combustion chambers reported in this paper will reduce manufacturing cost of the rhenium chambers by 25 percent, and reduce the manufacturing time by 30 to 40 percent. The quantity of rhenium metal powder used to produce a rhenium chamber is reduced by approximately 70 percent and the subsequent reduction in machining schedule and costs is nearly 50 percent.

  9. Iridium/Rhenium Parts For Rocket Engines

    NASA Technical Reports Server (NTRS)

    Schneider, Steven J.; Harding, John T.; Wooten, John R.

    1991-01-01

    Oxidation/corrosion of metals at high temperatures primary life-limiting mechanism of parts in rocket engines. Combination of metals greatly increases operating temperature and longevity of these parts. Consists of two transition-element metals - iridium and rhenium - that melt at extremely high temperatures. Maximum operating temperature increased to 2,200 degrees C from 1,400 degrees C. Increases operating lifetimes of small rocket engines by more than factor of 10. Possible to make hotter-operating, longer-lasting components for turbines and other heat engines.

  10. 5 CFR 185.126 - Evidence.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Evidence. 185.126 Section 185.126... § 185.126 Evidence. (a) The ALJ shall determine the admissibility of evidence. (b) Except as provided in this part, the ALJ shall not be bound by the Federal Rules of Evidence. However, the ALJ may apply...

  11. 5 CFR 185.126 - Evidence.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Evidence. 185.126 Section 185.126... § 185.126 Evidence. (a) The ALJ shall determine the admissibility of evidence. (b) Except as provided in this part, the ALJ shall not be bound by the Federal Rules of Evidence. However, the ALJ may apply...

  12. 5 CFR 185.126 - Evidence.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Evidence. 185.126 Section 185.126... § 185.126 Evidence. (a) The ALJ shall determine the admissibility of evidence. (b) Except as provided in this part, the ALJ shall not be bound by the Federal Rules of Evidence. However, the ALJ may apply...

  13. 40 CFR 68.185 - Certification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 16 2014-07-01 2014-07-01 false Certification. 68.185 Section 68.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.185 Certification. (a) For Program 1...

  14. 40 CFR 68.185 - Certification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Certification. 68.185 Section 68.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.185 Certification. (a) For Program 1...

  15. 40 CFR 68.185 - Certification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Certification. 68.185 Section 68.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.185 Certification. (a) For Program 1...

  16. 19 CFR 18.5 - Diversion.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Diversion. 18.5 Section 18.5 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT General Provisions § 18.5 Diversion. (a) Merchandise forwarded under any class of transportation entry may...

  17. 46 CFR 185.514 - Station bill.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Station bill. 185.514 Section 185.514 Shipping COAST...) OPERATIONS Preparations for Emergencies § 185.514 Station bill. (a) A station bill must be posted by the... requiring more than four crew members at any one time, including the master. (b) The station bill...

  18. 46 CFR 185.514 - Station bill.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Station bill. 185.514 Section 185.514 Shipping COAST...) OPERATIONS Preparations for Emergencies § 185.514 Station bill. (a) A station bill must be posted by the... requiring more than four crew members at any one time, including the master. (b) The station bill...

  19. 46 CFR 185.503 - Voyage plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Voyage plan. 185.503 Section 185.503 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.503 Voyage plan. (a) The master of the following vessels...

  20. 46 CFR 185.503 - Voyage plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Voyage plan. 185.503 Section 185.503 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.503 Voyage plan. (a) The master of the following vessels...

  1. 46 CFR 185.503 - Voyage plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Voyage plan. 185.503 Section 185.503 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.503 Voyage plan. (a) The master of the following vessels...

  2. 46 CFR 185.503 - Voyage plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Voyage plan. 185.503 Section 185.503 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.503 Voyage plan. (a) The master of the following vessels...

  3. 5 CFR 185.130 - Motions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Motions. 185.130 Section 185.130... § 185.130 Motions. (a) Any application to the ALJ for an order or ruling shall be by motion. Motions... the ALJ and served on all other parties. (b) Except for motions made during a prehearing conference...

  4. 5 CFR 185.130 - Motions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Motions. 185.130 Section 185.130... § 185.130 Motions. (a) Any application to the ALJ for an order or ruling shall be by motion. Motions... the ALJ and served on all other parties. (b) Except for motions made during a prehearing conference...

  5. 5 CFR 185.130 - Motions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Motions. 185.130 Section 185.130... § 185.130 Motions. (a) Any application to the ALJ for an order or ruling shall be by motion. Motions... the ALJ and served on all other parties. (b) Except for motions made during a prehearing conference...

  6. 5 CFR 185.130 - Motions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Motions. 185.130 Section 185.130... § 185.130 Motions. (a) Any application to the ALJ for an order or ruling shall be by motion. Motions... the ALJ and served on all other parties. (b) Except for motions made during a prehearing conference...

  7. 5 CFR 185.130 - Motions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Motions. 185.130 Section 185.130... § 185.130 Motions. (a) Any application to the ALJ for an order or ruling shall be by motion. Motions... the ALJ and served on all other parties. (b) Except for motions made during a prehearing conference...

  8. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN....185 Pineapple juice. (a) Identity. (1) Pineapple juice is the juice, intended for direct...

  9. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN....185 Pineapple juice. (a) Identity. (1) Pineapple juice is the juice, intended for direct...

  10. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN....185 Pineapple juice. (a) Identity. (1) Pineapple juice is the juice, intended for direct...

  11. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN....185 Pineapple juice. (a) Identity. (1) Pineapple juice is the juice, intended for direct...

  12. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN....185 Pineapple juice. (a) Identity. (1) Pineapple juice is the juice, intended for direct...

  13. 32 CFR 185.5 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Responsibilities. 185.5 Section 185.5 National... AUTHORITIES (DSCA) § 185.5 Responsibilities. (a) The Under Secretary of Defense for Policy (USD(P)) shall: (1... responsibilities in the matter, and Military Department Secretaries and other DoD officials as appropriate....

  14. 32 CFR 185.5 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Responsibilities. 185.5 Section 185.5 National... AUTHORITIES (DSCA) § 185.5 Responsibilities. (a) The Under Secretary of Defense for Policy (USD(P)) shall: (1... responsibilities in the matter, and Military Department Secretaries and other DoD officials as appropriate....

  15. 32 CFR 185.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Purpose. 185.1 Section 185.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.1 Purpose. This part: (a) Establishes policy and assigns responsibilities for DSCA,...

  16. 32 CFR 185.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Purpose. 185.1 Section 185.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.1 Purpose. This part: (a) Establishes policy and assigns responsibilities for DSCA,...

  17. 32 CFR 185.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Definitions. 185.3 Section 185.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.3 Definitions. Civil Authorities. See Joint Publication 1-02 14 . 14 Available...

  18. 32 CFR 185.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Definitions. 185.3 Section 185.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.3 Definitions. Civil Authorities. See Joint Publication 1-02 14 . 14 Available...

  19. 32 CFR 185.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Purpose. 185.1 Section 185.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.1 Purpose. This part: (a) Establishes policy and assigns responsibilities for DSCA,...

  20. 32 CFR 185.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Purpose. 185.1 Section 185.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.1 Purpose. This part: (a) Establishes policy and assigns responsibilities for DSCA,...

  1. 32 CFR 185.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Definitions. 185.3 Section 185.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.3 Definitions. Civil Authorities. See Joint Publication 1-02 14 . 14 Available...

  2. 32 CFR 185.4 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Policy. 185.4 Section 185.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.4 Policy. It is DoD policy that: (a) This part shall be implemented consistent...

  3. 32 CFR 185.4 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Policy. 185.4 Section 185.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.4 Policy. It is DoD policy that: (a) This part shall be implemented consistent...

  4. 46 CFR 185.503 - Voyage plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Voyage plan. 185.503 Section 185.503 Shipping COAST...) OPERATIONS Preparations for Emergencies § 185.503 Voyage plan. (a) The master of the following vessels shall prepare a voyage plan: (1) A vessel making an oceans or coastwise voyage; (2) A vessel making a voyage...

  5. 46 CFR 185.304 - Navigation underway.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Navigation underway. 185.304 Section 185.304 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Miscellaneous Operating Requirements § 185.304 Navigation underway. (a) The movement of...

  6. 46 CFR 185.304 - Navigation underway.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Navigation underway. 185.304 Section 185.304 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Miscellaneous Operating Requirements § 185.304 Navigation underway. (a) The movement of...

  7. 46 CFR 185.304 - Navigation underway.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Navigation underway. 185.304 Section 185.304 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Miscellaneous Operating Requirements § 185.304 Navigation underway. (a) The movement of...

  8. 46 CFR 185.510 - Emergency instructions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Emergency instructions. 185.510 Section 185.510 Shipping...) OPERATIONS Preparations for Emergencies § 185.510 Emergency instructions. (a) The master and crew of a vessel will be familiar with the content of and have mounted at the operating station, emergency...

  9. 46 CFR 45.185 - Tow limitations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Tow limitations. 45.185 Section 45.185 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.185 Tow limitations. (a) Barges must not be manned. (b) No more...

  10. 46 CFR 45.185 - Tow limitations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Tow limitations. 45.185 Section 45.185 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.185 Tow limitations. (a) Barges must not be manned. (b) No more...

  11. 46 CFR 45.185 - Tow limitations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Tow limitations. 45.185 Section 45.185 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.185 Tow limitations. (a) Barges must not be manned. (b) No more...

  12. 46 CFR 45.185 - Tow limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Tow limitations. 45.185 Section 45.185 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.185 Tow limitations. (a) Barges must not be manned. (b) No more...

  13. 46 CFR 45.185 - Tow limitations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Tow limitations. 45.185 Section 45.185 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.185 Tow limitations. (a) Barges must not be manned. (b) No more...

  14. 40 CFR 68.185 - Certification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 16 2012-07-01 2012-07-01 false Certification. 68.185 Section 68.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.185 Certification. (a) For Program 1...

  15. 46 CFR 185.410 - Watchmen.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Watchmen. 185.410 Section 185.410 Shipping COAST GUARD... Requirements § 185.410 Watchmen. The owner, charterer, master, or managing operator of a vessel carrying overnight passengers shall have a suitable number of watchmen patrol throughout the vessel during...

  16. 46 CFR 174.185 - Intact stability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Intact stability. 174.185 Section 174.185 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO SPECIFIC VESSEL TYPES Special Rules Pertaining to Offshore Supply Vessels § 174.185 Intact stability....

  17. 46 CFR 174.185 - Intact stability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Intact stability. 174.185 Section 174.185 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO SPECIFIC VESSEL TYPES Special Rules Pertaining to Offshore Supply Vessels § 174.185 Intact stability....

  18. 5 CFR 185.135 - The record.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false The record. 185.135 Section 185.135... § 185.135 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ at a cost not to exceed the actual cost of duplication. (b)...

  19. 5 CFR 185.135 - The record.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false The record. 185.135 Section 185.135... § 185.135 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ at a cost not to exceed the actual cost of duplication. (b)...

  20. 5 CFR 185.135 - The record.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false The record. 185.135 Section 185.135... § 185.135 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ at a cost not to exceed the actual cost of duplication. (b)...

  1. 5 CFR 185.135 - The record.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false The record. 185.135 Section 185.135... § 185.135 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ at a cost not to exceed the actual cost of duplication. (b)...

  2. 5 CFR 185.135 - The record.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false The record. 185.135 Section 185.135... § 185.135 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ at a cost not to exceed the actual cost of duplication. (b)...

  3. 5 CFR 185.142 - Judicial review.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Judicial review. 185.142 Section 185.142... § 185.142 Judicial review. Section 3805 of title 31, United States Code, authorizes judicial review by... penalties and/or assessments under this part and specifies the procedures for such review....

  4. 1 CFR 18.5 - Certified copies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Certified copies. 18.5 Section 18.5 General... DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.5 Certified copies. The certified copies or duplicate originals of each document must be submitted with the original. Each copy or...

  5. Rhenium labeled peptides and antibodies for cancer therapy. CRADA final report

    SciTech Connect

    Knapp, Jr., F. F.; Rhodes, B. A.

    1996-08-12

    This CRADA involved development of optimal methods for attachment of rhenium radioisotopes to antibodies and peptides which can be used for cancer treatment. Rhenium-186 and the tungsten-188/rhenium-188 generators were provided from ORNL to RhoMed for peptide labeling studies. The rhenium-186 and carrier-free rhenium-188 were then used to optimize the labeling of various small peptides....A system has been developed at ORNL which provides the rhenium-188 radioisotope, which has excellent therapeutic properties for cancer treatment.

  6. Toward hypoxia-selective rhenium and technetium tricarbonyl complexes.

    PubMed

    North, Andrea J; Hayne, David J; Schieber, Christine; Price, Katherine; White, Anthony R; Crouch, Peter J; Rigopoulos, Angela; O'Keefe, Graeme J; Tochon-Danguy, Henri; Scott, Andrew M; White, Jonathan M; Ackermann, Uwe; Donnelly, Paul S

    2015-10-01

    With the aim of preparing hypoxia-selective imaging and therapeutic agents, technetium(I) and rhenium(I) tricarbonyl complexes with pyridylhydrazone, dipyridylamine, and pyridylaminocarboxylate ligands containing nitrobenzyl or nitroimidazole functional groups have been prepared. The rhenium tricarbonyl complexes were synthesized with short reaction times using microwave irradiation. Rhenium tricarbonyl complexes with deprotonated p-nitrophenyl pyridylhydrazone ligands are luminescent, and this has been used to track their uptake in HeLa cells using confocal fluorescent microscopy. Selected rhenium tricarbonyl complexes displayed higher uptake in hypoxic cells when compared to normoxic cells. A (99m)Tc tricarbonyl complex with a dipyridylamine ligand bearing a nitroimidazole functional group is stable in human serum and was shown to localize in a human renal cell carcinoma (RCC; SK-RC-52) tumor in a mouse.

  7. Synthesis of the ytterbium derivatives of manganese and rhenium cyclopentadienyltricarbonyls

    SciTech Connect

    Kolobova, N.E.; Kazimirchuk, E.I.; Agdamskii, T.A.; Umudova, Z.M.; Khandozhko, V.N.; Suleimanov, G.Z.; Petrovskii, P.V.; Beletskaya, I.P.

    1988-01-20

    The direct metallation of manganese and rhenium cyclopentadienyltricarbonyl complexes by the action of PhYbI was studied. The metallation of the manganese complex with PhYbI leads to the formation of the Grignard-like compound (CO)/sub 3/MnC/sub 5/H/sub 4/YbI. The rhenium complex is not metallated by the action of PhYbI.

  8. Modification of 1,2,4,5-tetrazine with cationic rhenium(I) polypyridine units to afford phosphorogenic bioorthogonal probes with enhanced reaction kinetics.

    PubMed

    Choi, Alex Wing-Tat; Tso, Karson Ka-Shun; Yim, Vicki Man-Wai; Liu, Hua-Wei; Lo, Kenneth Kam-Wing

    2015-02-25

    New phosphorogenic bioorthogonal probes derived from mononuclear and binuclear rhenium(I) polypyridine complexes containing a 1,2,4,5-tetrazine moiety were designed; these complexes displayed substantial dienophile-induced emission enhancement, and accelerated reaction kinetics and could target a protein conjugate in living cells.

  9. Summary of Recent Target Studies

    SciTech Connect

    Bieniosek, F.; O'Day, S.

    1993-02-04

    This report describes recent measurements that have been performed with the new target stack (Fig. 1). Highlights of these measurements are: (1) Pbar yields of nickel and powdered rhenium are comparable to that of copper. (2) Enhancement of pbar yield at the interface between copper and aluminum disks in the target stack has been observed. This effect occurs only when the lens is focused near the upstream edge of the target. (3) The target density depletion study in powdered rhenium showed an apparent yield reduction on the time scale of a single proton pulse, accompanied by release of airborne radioactive material.

  10. Rhenium-188: availability from the (188)W/(188)Re generator and status of current applications.

    PubMed

    Pillai, M R A; Dash, Ashutosh; Knapp, F F

    2012-07-01

    Rhenium-188 is one of the most readily available generator derived and useful radionuclides for therapy emitting β(-) particles (2.12 MeV, 71.1% and 1.965 MeV, 25.6%) and imageable gammas (155 keV, 15.1%). The (188)W/(188)Re generator is an ideal source for the long term (4-6 months) continuous availability of no carrier added (nca) (188)Re suitable for the preparation of radiopharmaceuticals for radionuclide therapy. The challenges associated with the double neutron capture route of production of the parent (188)W radionuclide have been a major impediment in the progress of application of (188)Re. Tungsten-188 of adequate specific activity can be prepared only in 2-3 of the high flux reactors operating in the World. Several useful technologies have been developed for the preparation of clinical grade (188)W/(188)Re generators. Since the specific activity of (188)W used in the generator is relatively low 185 GBq( < 5 Ci)/g], the eluted (188)ReO(4)(-) can have low radioactive concentration often insufficient for radiopharmaceutical preparation. However, several efficient post elution concentration techniques have been developed that yield clinically useful (188)ReO(4)(-) solutions. Rhenium-188 has been used for the preparation of therapeutic radiopharmaceuticals for the management of diseases such as bone metastasis, rheumatoid arthritis and primary cancers. Several early phase clinical studies using radiopharmaceuticals based on (188)Re-labeled phosphonates, antibodies, peptides, lipiodol and particulates have been reported. This article reviews the availability and use of (188)Re including a discussion of why broader use of (188)Re has not progressed as expected as a popular radionuclide for therapy.

  11. Determination of rhenium in molybdenite by X-ray fluorescence. A combined chemical-spectrometric technique

    USGS Publications Warehouse

    Solt, M.W.; Wahlberg, J.S.; Myers, A.T.

    1969-01-01

    Rhenium in molybdenite is separated from molybdenum by distillation of rhenium heptoxide from a perchloric-sulphuric acid mixture. It is concentrated by precipitation of the sulphide and then determined by X-ray fluorescence. From 3 to 1000 ??g of rhenium can be measured with a precision generally within 2%. The procedure tolerates larger amounts of molybdenum than the usual colorimetric methods. ?? 1969.

  12. 40 CFR 421.210 - Applicability: Description of the primary molybdenum and rhenium subcategory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... primary molybdenum and rhenium subcategory. 421.210 Section 421.210 Protection of Environment... POINT SOURCE CATEGORY Primary Molybdenum and Rhenium Subcategory § 421.210 Applicability: Description of the primary molybdenum and rhenium subcategory. The provisions of this subpart are applicable...

  13. 40 CFR 421.210 - Applicability: Description of the primary molybdenum and rhenium subcategory.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... primary molybdenum and rhenium subcategory. 421.210 Section 421.210 Protection of Environment... POINT SOURCE CATEGORY Primary Molybdenum and Rhenium Subcategory § 421.210 Applicability: Description of the primary molybdenum and rhenium subcategory. The provisions of this subpart are applicable...

  14. 40 CFR 421.210 - Applicability: Description of the primary molybdenum and rhenium subcategory.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... primary molybdenum and rhenium subcategory. 421.210 Section 421.210 Protection of Environment... POINT SOURCE CATEGORY Primary Molybdenum and Rhenium Subcategory § 421.210 Applicability: Description of the primary molybdenum and rhenium subcategory. The provisions of this subpart are applicable...

  15. 40 CFR 421.210 - Applicability: Description of the primary molybdenum and rhenium subcategory.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... primary molybdenum and rhenium subcategory. 421.210 Section 421.210 Protection of Environment... POINT SOURCE CATEGORY Primary Molybdenum and Rhenium Subcategory § 421.210 Applicability: Description of the primary molybdenum and rhenium subcategory. The provisions of this subpart are applicable...

  16. 40 CFR 421.210 - Applicability: Description of the primary molybdenum and rhenium subcategory.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... primary molybdenum and rhenium subcategory. 421.210 Section 421.210 Protection of Environment... POINT SOURCE CATEGORY Primary Molybdenum and Rhenium Subcategory § 421.210 Applicability: Description of the primary molybdenum and rhenium subcategory. The provisions of this subpart are applicable...

  17. 40 CFR 46.185 - Activation notice.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Activation notice. 46.185 Section 46.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE...., if your program of study is at an EPA facility, the EPA project officer may sign as sponsor on...

  18. 40 CFR 46.185 - Activation notice.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Activation notice. 46.185 Section 46.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE...., if your program of study is at an EPA facility, the EPA project officer may sign as sponsor on...

  19. 27 CFR 27.185 - Customs release.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Customs release. 27.185... Distilled Spirits From Customs Custody Free of Tax for Use of the United States § 27.185 Customs release. (a) Upon receipt of appropriate customs entry and a photocopy of a permit, Form 5150.33 or...

  20. 5 CFR 185.120 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Prehearing conferences. 185.120 Section 185.120 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM... hearing and to submit only documentary evidence (subject to the objection of other parties) and...

  1. 15 CFR 922.185 - Emergency regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Emergency regulations. 922.185 Section... Sanctuary § 922.185 Emergency regulations. Where necessary to prevent or minimize the destruction of, loss... relevant Federal agency and the Governor of the State of Hawaii. Emergency regulations shall not...

  2. 15 CFR 922.185 - Emergency regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Emergency regulations. 922.185 Section 922.185 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued... MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National...

  3. 15 CFR 922.185 - Emergency regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Emergency regulations. 922.185 Section 922.185 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued... MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National...

  4. 15 CFR 922.185 - Emergency regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Emergency regulations. 922.185 Section 922.185 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued... MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National...

  5. 15 CFR 922.185 - Emergency regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Emergency regulations. 922.185 Section 922.185 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued... MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National...

  6. 7 CFR 65.185 - Ingredient.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Ingredient. 65.185 Section 65.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...

  7. 7 CFR 65.185 - Ingredient.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Ingredient. 65.185 Section 65.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...

  8. 7 CFR 65.185 - Ingredient.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Ingredient. 65.185 Section 65.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...

  9. 7 CFR 65.185 - Ingredient.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Ingredient. 65.185 Section 65.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...

  10. 7 CFR 65.185 - Ingredient.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Ingredient. 65.185 Section 65.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...

  11. 40 CFR 46.185 - Activation notice.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE FELLOWSHIPS During the Fellowship § 46.185 Activation notice. (a) Each fellowship includes a “Fellowship... Activation Notice when the program supported by the fellowship agreement begins. In certain instances,...

  12. 40 CFR 46.185 - Activation notice.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE FELLOWSHIPS During the Fellowship § 46.185 Activation notice. (a) Each fellowship includes a “Fellowship... Activation Notice when the program supported by the fellowship agreement begins. In certain instances,...

  13. 40 CFR 46.185 - Activation notice.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE FELLOWSHIPS During the Fellowship § 46.185 Activation notice. (a) Each fellowship includes a “Fellowship... Activation Notice when the program supported by the fellowship agreement begins. In certain instances,...

  14. 7 CFR 1150.185 - Amendments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Amendments. 1150.185 Section 1150.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and...

  15. 7 CFR 1150.185 - Amendments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 9 2012-01-01 2012-01-01 false Amendments. 1150.185 Section 1150.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and...

  16. 7 CFR 1150.185 - Amendments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 9 2013-01-01 2013-01-01 false Amendments. 1150.185 Section 1150.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and...

  17. 7 CFR 1150.185 - Amendments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Amendments. 1150.185 Section 1150.185 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and...

  18. Effect of rhenium on the structure and properties of the weld metal of a molybdenum alloy

    NASA Technical Reports Server (NTRS)

    Dyachenko, V. V.; Morozov, B. P.; Tylkina, M. A.; Savitskiy, Y. M.; Nikishanov, V. V.

    1984-01-01

    The structure and properties of welds made in molybdenum alloy VM-1 as a function of rhenium concentrations in the weld metal were studied. Rhenium was introduced into the weld using rhenium wire and tape or wires of Mo-47Re and Mo-52Re alloys. The properties of the weld metal were studied by means of metallographic techniques, electron microscopy, X-ray analysis, and autoradiography. The plasticity of the weld metal sharply was found to increase with increasing concentration of rhenium up to 50%. During welding, a decarburization process was observed which was more pronounced at higher concentrations of rhenium.

  19. The Role of Rhenium on the Temporal Evolution of the Nanostructure of a Model Ni-Al-Cr-Re Superalloy

    NASA Technical Reports Server (NTRS)

    Yoon, Kevin E.; Noebe, Ronald D.; Seidman, David N.

    2004-01-01

    Rhenium (2 at.%) additions to a model Ni-8.5 at.% Cr-10 at.% Al alloy are studied with respect to its effects on the temporal evolution of the nanostructure and the partitioning behavior of the four elements between the gamma (fcc) and gamma' (L1(sub 2)) phases. Chemical evolution of this quaternary alloy aged at 1073 K from 0.25 to 264 h, is investigated by three-dimensional atom-probe (3DAP) microscopy. The morphology of gamma'-precipitates remains spheroidal, even at an aging time of 264 h. The results demonstrate that Re slows the coarsening of gamma'-precipitates, in comparison to the ternary Ni-10 at.% A1-8.5 at.% Cr alloy at 1073 K.

  20. Mechanical properties of electron-beam-melted molybdenum and dilute molybdenum-rhenium alloys

    NASA Technical Reports Server (NTRS)

    Klopp, W. D.; Witzke, W. R.

    1972-01-01

    A study of molybdenum and three dilute molybdenum-rhenium alloys was undertaken to determine the effects of rhenium on the low temperature ductility and other mechanical properties of molybdenum. Alloys containing 3.9, 5.9, and 7.7 atomic percent rhenium exhibited lower ductile-brittle transition temperatures than did the unalloyed molybdenum. The maximum improvement in the annealed condition was observed for molybdenum - 7.7 rhenium, which had a ductile-brittle transition temperature approximately 200 C (360 F) lower than that for unalloyed molybdenum. Rhenium additions also increased the low and high temperature tensile strengths and the high temperature creep strength of molybdenum. The mechanical behavior of dilute molybdenum-rhenium alloys is similar to that observed for dilute tungsten-rhenium alloys.

  1. Rhenium-188--a generator-derived radioisotope for cancer therapy.

    PubMed

    Knapp, F F

    1998-10-01

    Rhenium-188 (188Re) is an important therapeutic radioisotope which is obtained on demand as carrier-free sodium perrhenate by saline elution of the tungsten-188/rhenium-188 generator system. With a half-life of 16.9 hours and emission of a high energy beta particle (maximal energy of 2.12 MeV) and a gamma photon (155 keV, 15%) for imaging, 188Re can be provided at reasonable costs for routine preparation of radiopharmaceuticals for cancer treatment. PMID:10851424

  2. Mechanistic Study of Oxygen Atom Transfer Catalyzed by Rhenium Compounds

    SciTech Connect

    Xiaopeng Shan

    2003-08-05

    Two ionic and one neutral methyl(oxo)rhenium(V) compounds were synthesized and structurally characterized. They were compared in reactivity towards the ligands triphenylphosphane, pyridines, pyridine N-oxides. Assistance from Broensted bases was found on ligand displacement of ionic rhenium compounds as well as nucleophile assistance on oxidation of all compounds. From the kinetic data, crystal structures, and an analysis of the intermediates, a structural formula of PicH{sup +}3{sup -} and mechanisms of ligand displacement and oxidation were proposed.

  3. Rhenium-catalyzed deoxydehydration of diols and polyols.

    PubMed

    Dethlefsen, Johannes R; Fristrup, Peter

    2015-03-01

    The substitution of platform chemicals of fossil origin by biomass-derived analogues requires the development of chemical transformations capable of reducing the very high oxygen content of biomass. One such reaction, which has received increasing attention within the past five years, is the rhenium-catalyzed deoxydehydration (DODH) of a vicinal diol into an alkene; this is a model system for abundant polyols like glycerol and sugar alcohols. The present contribution includes a review of early investigations of stoichiometric reactions involving rhenium, diols, and alkenes followed by a discussion of the various catalytic systems that have been developed with emphasis on the nature of the reductant, the substrate scope, and mechanistic investigations.

  4. 40 CFR 68.185 - Certification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.185 Certification. (a) For Program 1 processes... certification that, to the best of the signer's knowledge, information, and belief formed after...

  5. 5 CFR 185.122 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... § 185.122 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... document or of the truth of any relevant fact; (3) Written interrogatories; and (4) Depositions. (b)...

  6. Diffusion in the nickel-rhenium system

    SciTech Connect

    Neubauer, C.M.; Mari, D.; Dunand, D.C. . Dept. of Materials Science and Engineering)

    1994-07-01

    Most Ni-based metal matrix composites (MMC) studied to date were reinforced with ductile refractory metal fibers, mostly W or W-alloys. However, Ni embrittles and weakens cold-drawn W fibers by (1) forming intermetallic phases at the fiber-matrix interface and (2) inducing recrystallization of W at temperatures as low as 950 C by rapid grain-boundary diffusion. To prevent these problems, ceramic coatings with low solubility, reactivity, and diffusion coefficients for both W and Ni can be applied at the interface. However, ceramic coatings are brittle, and typically exhibit a large mismatch of coefficient of thermal expansion with Ni; therefore, these coatings tend to crack when the composite is subjected to thermal cycling. To prevent cracking of the diffusion barrier, ductile, metallic coatings can be used. Rhenium is an attractive candidate for W fibers in a Ni matrix, since it exhibits high-temperature strength significantly higher than W, while retaining excellent ductility at all temperatures, even after recrystallization. Also, its coefficient of thermal expansion is between those of W and Ni. Diffusion in the Re-W system at the potential use temperatures of Ni-based MMC (1,200--1,500 K) is negligible due to the very high melting points of both W and Re (3,695 K and 3,459 K, respectively). Furthermore, Re additions have been found to improve the mechanical properties of both W and Ni. Finally, the Ni-Re phase diagram shows a simple peritectic system with no intermetallic present. However, one potential drawback is the relatively high solubility of each metal in the other. The authors present an experimental investigation of diffusion phenomena in the Ni-Re system. The parameters controlling diffusion (activation energy and frequency factor) of each metal into the other are determined in order to predict long-term diffusion behavior at elevated temperatures and to assess the suitability of Re diffusion coatings for W fibers in Ni-based matrices.

  7. Rhenium Disulfide Depletion-Load Inverter

    NASA Astrophysics Data System (ADS)

    McClellan, Connor; Corbet, Chris; Rai, Amritesh; Movva, Hema C. P.; Tutuc, Emanuel; Banerjee, Sanjay K.

    2015-03-01

    Many semiconducting Transition Metal Dichalcogenide (TMD) materials have been effectively used to create Field-Effect Transistor (FET) devices but have yet to be used in logic designs. We constructed a depletion-load voltage inverter using ultrathin layers of Rhenium Disulfide (ReS2) as the semiconducting channel. This ReS2 inverter was fabricated on a single micromechanically-exfoliated flake of ReS2. Electron beam lithography and physical vapor deposition were used to construct Cr/Au electrical contacts, an Alumina top-gate dielectric, and metal top-gate electrodes. By using both low (Aluminum) and high (Palladium) work-function metals as two separate top-gates on a single ReS2 flake, we create a dual-gated depletion mode (D-mode) and enhancement mode (E-mode) FETs in series. Both FETs displayed current saturation in the output characteristics as a result of the FET ``pinch-off'' mechanism and On/Off current ratios of 105. Field-effect mobilities of 23 and 17 cm2V-1s-1 and subthreshold swings of 97 and 551 mV/decade were calculated for the E-mode and D-mode FETs, respectively. With a supply voltage of 1V, at low/negative input voltages the inverter output was at a high logic state of 900 mV. Conversely with high/positive input voltages, the inverter output was at a low logic state of 500 mV. The inversion of the input signal demonstrates the potential for using ReS2 in future integrated circuit designs and the versatility of depletion-load logic devices for TMD research. NRI SWAN Center and ARL STTR Program.

  8. Characterization of rhenium oxide films and their application to liquid crystal cells

    SciTech Connect

    Cazzanelli, E.; Castriota, M.; Marino, S.; Scaramuzza, N.; Purans, J.; Kuzmin, A.; Kalendarev, R.; Mariotto, G.; Das, G.

    2009-06-01

    Rhenium trioxide exhibits high electronic conductivity, while its open cubic crystal structure allows an appreciable hydrogen intercalation, generating disordered solid phases, with protonic conductivity. Rhenium oxide thin films have been obtained by thermal evaporation of ReO{sub 3} powders on different substrates, maintained at different temperatures, and also by reactive magnetron sputtering of a Re metallic target. A comparative investigation has been carried out on these films, by using micro-Raman spectroscopy and x-ray diffraction. Two basic types of solid phases appear to grow in the films: a red metallic H{sub x}ReO{sub 3} compound, with distorted perovskite structures, like in the bulk material, and ordered HReO{sub 4} crystals based on tetrahedral perrhenate ions. Because of its conduction properties, the electrical and electro-optical behaviors of ReO{sub 3} films deposited on standard indium tin oxide/glass substrate have been tested inside asymmetric nematic liquid crystal cells, showing an appreciable capability of rectification of their electro-optical response, in similar way to tungsten trioxide.

  9. Application of rhenium-188 HEDP in bone metastases therapy.

    PubMed

    Scheffler, Justyna; Derejko, Mirosława; Bandurski, Tomasz; Romanowicz, Grzegorz

    2003-01-01

    Radionuclide bone metastases therapy is a major achievement of nuclear medicine. Development of less radiotoxic and more effective radiopharmaceuticals is therefore a challenge for radiopharmacists and industry. This paper reviews the application of rhenium-188 HEDP as a reactor- or generator-produced nuclide for bone metastases therapy. PMID:14600935

  10. Discovery of tantalum, rhenium, osmium, and iridium isotopes

    SciTech Connect

    Robinson, R.; Thoennessen, M.

    2012-09-15

    Currently, thirty-eight tantalum, thirty-eight rhenium, thirty-nine osmium, and thirty-eight iridium isotopes have been observed and the discovery of these isotopes is described here. For each isotope a brief synopsis of the first refereed publication, including the production and identification method, is presented.

  11. Rhenium(I)-based Double-heterostranded Helicates.

    PubMed

    Saxena, Priya; Shankar, Bhaskaran; Sathyanarayana, Arruri; Prabusankar, Ganesan; Sathiyendiran, Malaichamy

    2015-01-01

    Rhenium(I)-based supramolecular coordination complexes were obtained using Re2(CO)10, (2-hydroxyphenyl)benzimidazole-derived bis-chelating N∩O donors and a benzimidazolyl-derived ditopic monodentate N-donor possessing Troger's base spacer in a one-pot approach.

  12. Combination of three metals for the treatment of cancer: gallium, rhenium and platinum. 1. Determination of the optimal schedule of treatment.

    PubMed

    Collery, Philippe; Mohsen, Ahmed; Kermagoret, Anthony; D'Angelo, Jean; Morgant, Georges; Desmaele, Didier; Tomas, Alain; Collery, Thomas; Wei, Ming; Badawi, Abdelfattah

    2012-07-01

    Platinum is well known for its anticancer activity, firstly used as cis-diaminedichloroplatinum (II) (CDDP), with a wide range of activity. Its main mechanism of action involves its binding to DNA. Gallium, another metal, has also demonstrated apoptotic effects on malignant cells, but through interaction with targets other than DNA, such as the membrane, cytoskeleton and proteasome, and on enzyme activities. An antitumor synergism between CDDP and both gallium and rhenium compounds has been demonstrated. For these reasons, we proposed to combine these three metals and to determine at which doses each compound could be administered without major toxicity. CDDP, tetrakis(1-octanol) tris(5-aminosalicylate)gallium(III), and a diseleno-ether rhenium(I) complex were used in this experimental study in breast cancer MCF-7 tumor-bearing mice. CDDP was administered intraperitoneally (i.p.) twice a week at the dose of 3 mg/kg. Tetrakis(1-octanol) tris(5-aminosalicylate) gallium (III) and rhenium(I) diseleno-ether complexes were administered orally, daily, five days a week for three weeks, at doses ranging from 20 to 100 mg/kg for the gallium compound and from 10 to 50 mg/kg for the rhenium compound. Doses of 10 mg/kg of rhenium(I) diseleno-ether, and 100 mg/kg of the salicylate gallium compound, in combination with CDDP induced a significant decrease of 50% of the tumor volume, by comparison with the control group. In contrast, the decrease of the tumor volume in mice treated by CDDP alone was less than 25%. Changes in the sequence of administration of the three metals will be discussed to improve the therapeutic index.

  13. Supported rhenium complexes: almost uniform rhenium tricarbonyls synthesized from CH3Re(CO)5 and HY zeolite.

    PubMed

    Lobo-Lapidus, Rodrigo J; Gates, Bruce C

    2010-11-01

    Supported rhenium complexes were prepared from CH(3)Re(CO)(5) and dealuminated HY zeolite or NaY zeolite, each with a Si/Al atomic ratio of 30. The samples were characterized with infrared (IR) and extended X-ray absorption fine structure (EXAFS) spectroscopies. EXAFS data characterizing the sample formed by the reaction of CH(3)Re(CO)(5) with dealuminated HY zeolite show that the rhenium complexes were bonded to the zeolite frame, incorporating, on average, three carbonyl ligands per Re atom (as shown by Re-C and multiple-scattering Re-O EXAFS contributions). The IR spectra, consistent with this result, show that the supported rhenium carbonyls were bonded near aluminum sites of the zeolite, as shown by the decrease in intensity of the IR bands characterizing the acidic silanol groups resulting from the reaction of the rhenium carbonyl with the zeolite. This supported metal complex was characterized by narrow peaks in the ν(CO) region of the IR spectrum, indicating highly uniform species. In contrast, the species formed from CH(3)Re(CO)(5) on NaY zeolite lost fewer carbonyl ligands than those formed on HY zeolite and were significantly less uniform, as indicated by the greater breadth of the ν(CO) bands in the IR spectra. The results show the importance of zeolite H(+) sites for the formation of uniform supported rhenium carbonyls from CH(3)Re(CO)(5); the formation of such uniform complexes did not occur on the NaY zeolite.

  14. RNF185, a Novel Mitochondrial Ubiquitin E3 Ligase, Regulates Autophagy through Interaction with BNIP1

    PubMed Central

    Tang, Fei; Wang, Bin; Li, Na; Wu, Yanfang; Jia, Junying; Suo, Talin; Chen, Quan; Liu, Yong-Jun; Tang, Jie

    2011-01-01

    Autophagy is an evolutionarily conserved catabolic process that allows recycling of cytoplasmic organelles, such as mitochondria, to offer a bioenergetically efficient pathway for cell survival. Considerable progress has been made in characterizing mitochondrial autophagy. However, the dedicated ubiquitin E3 ligases targeting mitochondria for autophagy have not been revealed. Here we show that human RNF185 is a mitochondrial ubiquitin E3 ligase that regulates selective mitochondrial autophagy in cultured cells. The two C-terminal transmembrane domains of human RNF185 mediate its localization to mitochondrial outer membrane. RNF185 stimulates LC3II accumulation and the formation of autophagolysosomes in human cell lines. We further identified the Bcl-2 family protein BNIP1 as one of the substrates for RNF185. Human BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage in vivo. The polyubiquitinated BNIP1 is capable of recruiting autophagy receptor p62, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy. Our study might reveal a novel RNF185-mediated mechanism for modulating mitochondrial homeostasis through autophagy. PMID:21931693

  15. 14 CFR 61.185 - Aeronautical knowledge.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Flight Instructors With a Sport Pilot Rating § 61.185 Aeronautical knowledge. (a) A person who is applying for a flight instructor certificate must receive and log ground training from an authorized... testing; (iv) Course development; (v) Lesson planning; and (vi) Classroom training techniques. (2)...

  16. 28 CFR 18.5 - Hearings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Administration DEPARTMENT OF JUSTICE OFFICE OF JUSTICE PROGRAMS HEARING AND APPEAL PROCEDURES § 18.5 Hearings. (a... inform the party of the reasons for the agency's proposed action; (2) A statement of the nature of the action proposed to be taken; and (3) A reference of the available appeal rights. (c) If a block...

  17. 28 CFR 18.5 - Hearings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Administration DEPARTMENT OF JUSTICE OFFICE OF JUSTICE PROGRAMS HEARING AND APPEAL PROCEDURES § 18.5 Hearings. (a... inform the party of the reasons for the agency's proposed action; (2) A statement of the nature of the action proposed to be taken; and (3) A reference of the available appeal rights. (c) If a block...

  18. 28 CFR 18.5 - Hearings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administration DEPARTMENT OF JUSTICE OFFICE OF JUSTICE PROGRAMS HEARING AND APPEAL PROCEDURES § 18.5 Hearings. (a... inform the party of the reasons for the agency's proposed action; (2) A statement of the nature of the action proposed to be taken; and (3) A reference of the available appeal rights. (c) If a block...

  19. 28 CFR 18.5 - Hearings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Administration DEPARTMENT OF JUSTICE OFFICE OF JUSTICE PROGRAMS HEARING AND APPEAL PROCEDURES § 18.5 Hearings. (a... inform the party of the reasons for the agency's proposed action; (2) A statement of the nature of the action proposed to be taken; and (3) A reference of the available appeal rights. (c) If a block...

  20. 28 CFR 18.5 - Hearings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Administration DEPARTMENT OF JUSTICE OFFICE OF JUSTICE PROGRAMS HEARING AND APPEAL PROCEDURES § 18.5 Hearings. (a... inform the party of the reasons for the agency's proposed action; (2) A statement of the nature of the action proposed to be taken; and (3) A reference of the available appeal rights. (c) If a block...

  1. 40 CFR 300.185 - Nongovernmental participation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 300.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY... of those plans in accordance with the requirements of 30 CFR part 254, 33 CFR parts 150, 154, and...

  2. 40 CFR 300.185 - Nongovernmental participation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 300.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY... of those plans in accordance with the requirements of 30 CFR part 254, 33 CFR parts 150, 154, and...

  3. 40 CFR 300.185 - Nongovernmental participation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 300.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY... of those plans in accordance with the requirements of 30 CFR part 254, 33 CFR parts 150, 154, and...

  4. 40 CFR 300.185 - Nongovernmental participation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 300.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY... of those plans in accordance with the requirements of 30 CFR part 254, 33 CFR parts 150, 154, and...

  5. 27 CFR 25.185 - Mingling.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... THE TREASURY ALCOHOL BEER Removals Without Payment of Tax Transfer to Another Brewery of Same Ownership § 25.185 Mingling. Beer transferred without payment of tax from one brewery to another brewery belonging to the same brewer may be mingled with beer of the receiving brewery. The brewer may handle...

  6. 27 CFR 25.185 - Mingling.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... THE TREASURY LIQUORS BEER Removals Without Payment of Tax Transfer to Another Brewery of Same Ownership § 25.185 Mingling. Beer transferred without payment of tax from one brewery to another brewery belonging to the same brewer may be mingled with beer of the receiving brewery. The brewer may handle...

  7. 27 CFR 25.185 - Mingling.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... THE TREASURY LIQUORS BEER Removals Without Payment of Tax Transfer to Another Brewery of Same Ownership § 25.185 Mingling. Beer transferred without payment of tax from one brewery to another brewery belonging to the same brewer may be mingled with beer of the receiving brewery. The brewer may handle...

  8. 27 CFR 25.185 - Mingling.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... THE TREASURY ALCOHOL BEER Removals Without Payment of Tax Transfer to Another Brewery of Same Ownership § 25.185 Mingling. Beer transferred without payment of tax from one brewery to another brewery belonging to the same brewer may be mingled with beer of the receiving brewery. The brewer may handle...

  9. 27 CFR 25.185 - Mingling.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... THE TREASURY LIQUORS BEER Removals Without Payment of Tax Transfer to Another Brewery of Same Ownership § 25.185 Mingling. Beer transferred without payment of tax from one brewery to another brewery belonging to the same brewer may be mingled with beer of the receiving brewery. The brewer may handle...

  10. 5 CFR 185.134 - Witnesses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... § 185.134 Witnesses. (a) Except as provided in paragraph (b) of this section, testimony at the hearing..., testimony may be admitted in the form of a written statement or deposition. Any such written statement must be provided to all others parties along with the last known address of such witness, in a...

  11. 32 CFR 185.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... specifically defined in DoD Directive 3025.12. 5 5 See footnote 4 to § 185.1(f). Civil emergency. Any natural... delegated authority of the DoD Executive Agency to coordinate MSCA activities under this Directive. The... Disaster Assistance under DoD Directive 5100.46 6 and to MSCA under the authority of this part. 6...

  12. 40 CFR 61.185 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.185 Recordkeeping... arsenic to the atmosphere between the time of discovery and the time corrective action was taken. (c) Each... ambient inorganic arsenic concentrations at all sampling sites and other data needed to determine...

  13. 40 CFR 61.185 - Recordkeeping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.185 Recordkeeping... arsenic to the atmosphere between the time of discovery and the time corrective action was taken. (c) Each... ambient inorganic arsenic concentrations at all sampling sites and other data needed to determine...

  14. 40 CFR 61.185 - Recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.185 Recordkeeping... arsenic to the atmosphere between the time of discovery and the time corrective action was taken. (c) Each... ambient inorganic arsenic concentrations at all sampling sites and other data needed to determine...

  15. 40 CFR 61.185 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.185 Recordkeeping... arsenic to the atmosphere between the time of discovery and the time corrective action was taken. (c) Each... ambient inorganic arsenic concentrations at all sampling sites and other data needed to determine...

  16. 40 CFR 61.185 - Recordkeeping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.185 Recordkeeping... arsenic to the atmosphere between the time of discovery and the time corrective action was taken. (c) Each... ambient inorganic arsenic concentrations at all sampling sites and other data needed to determine...

  17. 14 CFR 61.185 - Aeronautical knowledge.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Flight Instructors With a Sport Pilot Rating § 61.185 Aeronautical knowledge. (a) A person who is applying for a flight instructor certificate must receive and log ground training from an authorized... testing; (iv) Course development; (v) Lesson planning; and (vi) Classroom training techniques. (2)...

  18. 14 CFR 61.185 - Aeronautical knowledge.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Flight Instructors With a Sport Pilot Rating § 61.185 Aeronautical knowledge. (a) A person who is applying for a flight instructor certificate must receive and log ground training from an authorized... testing; (iv) Course development; (v) Lesson planning; and (vi) Classroom training techniques. (2)...

  19. 14 CFR 61.185 - Aeronautical knowledge.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Flight Instructors With a Sport Pilot Rating § 61.185 Aeronautical knowledge. (a) A person who is applying for a flight instructor certificate must receive and log ground training from an authorized... testing; (iv) Course development; (v) Lesson planning; and (vi) Classroom training techniques. (2)...

  20. Rhenium and Molybdenum in Rivers and Estuaries.

    NASA Astrophysics Data System (ADS)

    Walker, B. D.; Peucker-Ehrenbrink, B.

    2004-12-01

    Due to their redox-sensitive nature, the geochemical cycles of Re and Mo are linked to the global organic carbon cycle. Reducing sediments constitute a globally important sink and weathering of organic-rich sediments is responsible for a large portion of the Re and - to a lesser extent - Mo flux to the oceans (Colodner et al., 1993; Jaffe et al., 2002). Riverine concentrations of Re and Mo are a function of the river basin lithology, but are also likely to be affected by anthropogenic contributions (Colodner et al., 1995). Current estimates of global natural riverine Re flux are restricted to single analyses of four major rivers, which characterize only 23%\\ of the global freshwater flux (Colodner et al., 1993). Annual variability of Re and Mo concentrations in rivers has not been studied. A single study of Re concentrations along the salinity gradient of the Amazon shelf is suggestive of conservative mixing, but scatter in the data do not allow to exclude the possibility of Re addition in the low-salinity end of the profile (Colodner et al., 1993). Careful evaluation of samples from the Hudson River estuary using a variety of extraction techniques indicates that spike-sample equilibration was not fully achieved using commonly used methods. We have therefore developed a simple, clean and efficient method of extracting Re from filtered water samples. Our method utilizes syringe filtration, prolonged heating to achieve spike-sample equilibration, batch equilibration with TEVA resin, and extraction of Re and Mo using syringe filtration. Rhenium concentrations in the Hudson, Housatonic and Connecticut rivers are 38 pM, 6.6 pM and 14 pM, respectively, much higher than the estimated global average of 2.1 pM (Colodner et al., 1993). Molybdenum concentrations are 4.6 nM, 5.5 nM, 7.8 nM, respectively. These rivers drain basins of Precambrian basement as well as predominantly Paleozoic sediments and have been substantially urbanized. Data for a salinity profile along the

  1. Necroptosis-Inducing Rhenium(V) Oxo Complexes

    PubMed Central

    Suntharalingam, Kogularamanan; Awuah, Samuel G.; Bruno, Peter M.; Johnstone, Timothy C.; Wang, Fang; Lin, Wei; Zheng, Yao-Rong; Page, Julia E.; Hemann, Michael T.; Lippard, Stephen J.

    2015-01-01

    Rhenium(V) oxo complexes of general formula [ReO(OMe)(N^N)Cl2], where N^N = 4,7-diphenyl-1,10-phenanthroline, 1, or 3,4,7,8-tetramethyl-1,10-phenanthroline, 2, effectively kill cancer cells by triggering necroptsosis, a non-apoptotic form of cell death. Both complexes evoke necrosome (RIP1-RIP3)-dependent intracellular ROS production and propidium iodide uptake. The complexes also induce mitochondrial membrane potential depletion, a possible downstream effect of ROS production. Apparently, 1 and 2 are the first rhenium complexes to evoke cellular events consistent with programmed necrosis in cancer cells. Furthermore, 1 and 2 display low acute toxicity in C57BL/6 mice and reasonable stability in fresh human blood. PMID:25698398

  2. Necroptosis-inducing rhenium(V) oxo complexes.

    PubMed

    Suntharalingam, Kogularamanan; Awuah, Samuel G; Bruno, Peter M; Johnstone, Timothy C; Wang, Fang; Lin, Wei; Zheng, Yao-Rong; Page, Julia E; Hemann, Michael T; Lippard, Stephen J

    2015-03-01

    Rhenium(V) oxo complexes of general formula [ReO(OMe)(N^N)Cl2], where N^N = 4,7-diphenyl-1,10-phenanthroline, 1, or 3,4,7,8-tetramethyl-1,10-phenanthroline, 2, effectively kill cancer cells by triggering necroptosis, a non-apoptotic form of cell death. Both complexes evoke necrosome (RIP1-RIP3)-dependent intracellular reactive oxygen species (ROS) production and propidium iodide uptake. The complexes also induce mitochondrial membrane potential depletion, a possible downstream effect of ROS production. Apparently, 1 and 2 are the first rhenium complexes to evoke cellular events consistent with programmed necrosis in cancer cells. Furthermore, 1 and 2 display low acute toxicity in C57BL/6 mice and reasonable stability in fresh human blood.

  3. Rhenium complexes with visible-light-induced anticancer activity.

    PubMed

    Kastl, Anja; Dieckmann, Sandra; Wähler, Kathrin; Völker, Timo; Kastl, Lena; Merkel, Anna Lena; Vultur, Adina; Shannan, Batool; Harms, Klaus; Ocker, Matthias; Parak, Wolfgang J; Herlyn, Meenhard; Meggers, Eric

    2013-06-01

    Shedding light on the matter: Rhenium(I) indolato complexes with highly potent visible-light-triggered antiproliferative activity (complex 1: EC50 light=0.1 μM vs EC50 dark=100 μM) in 2D- and 3D-organized cancer cells are reported and can be traced back to an efficient generation of singlet oxygen, causing rapid morphological changes and an induction of apoptosis.

  4. CVD Rhenium Engines for Solar-Thermal Propulsion Systems

    NASA Technical Reports Server (NTRS)

    Williams, Brian E.; Fortini, Arthur J.; Tuffias, Robert H.; Duffy, Andrew J.; Tucker, Stephen P.

    1999-01-01

    Solar-thermal upper-stage propulsion systems have the potential to provide specific impulse approaching 900 seconds, with 760 seconds already demonstrated in ground testing. Such performance levels offer a 100% increase in payload capability compared to state-of-the-art chemical upper-stage systems, at lower cost. Although alternatives such as electric propulsion offer even greater performance, the 6- to 18- month orbital transfer time is a far greater deviation from the state of the art than the one to two months required for solar propulsion. Rhenium metal is the only material that is capable of withstanding the predicted thermal, mechanical, and chemical environment of a solar-thermal propulsion device. Chemical vapor deposition (CVD) is the most well-established and cost-effective process for the fabrication of complex rhenium structures. CVD rhenium engines have been successfully constructed for the Air Force ISUS program (bimodal thrust/electricity) and the NASA Shooting Star program (thrust only), as well as under an Air Force SBIR project (thrust only). The bimodal engine represents a more long-term and versatile approach to solar-thermal propulsion, while the thrust-only engines provide a potentially lower weight/lower cost and more near-term replacement for current upper-stage propulsion systems.

  5. Rhenium Complexes and Clusters Supported on c-Al2O3: Effects of Rhenium Oxidation State and Rhenium Cluster Size on Catalytic Activity for n-butane Hydrogenolysis

    SciTech Connect

    Lobo Lapidus, R.; Gates, B

    2009-01-01

    Supported metals prepared from H{sub 3}Re{sub 3}(CO){sub 12} on {gamma}-Al{sub 2}O{sub 3} were treated under conditions that led to various rhenium structures on the support and were tested as catalysts for n-butane conversion in the presence of H{sub 2} in a flow reactor at 533 K and 1 atm. After use, two samples were characterized by X-ray absorption edge positions of approximately 5.6 eV (relative to rhenium metal), indicating that the rhenium was cationic and essentially in the same average oxidation state in each. But the Re-Re coordination numbers found by extended X-ray absorption fine structure spectroscopy (2.2 and 5.1) show that the clusters in the two samples were significantly different in average nuclearity despite their indistinguishable rhenium oxidation states. Spectra of a third sample after catalysis indicate approximately Re{sub 3} clusters, on average, and an edge position of 4.5 eV. Thus, two samples contained clusters approximated as Re{sub 3} (on the basis of the Re-Re coordination number), on average, with different average rhenium oxidation states. The data allow resolution of the effects of rhenium oxidation state and cluster size, both of which affect the catalytic activity; larger clusters and a greater degree of reduction lead to increased activity.

  6. enantio-Enriched CPL-active helicene-bipyridine-rhenium complexes.

    PubMed

    Saleh, Nidal; Srebro, Monika; Reynaldo, Thibault; Vanthuyne, Nicolas; Toupet, Loïc; Chang, Victoria Y; Muller, Gilles; Williams, J A Gareth; Roussel, Christian; Autschbach, Jochen; Crassous, Jeanne

    2015-03-01

    The incorporation of a rhenium atom within an extended helical π-conjugated bi-pyridine system impacts the chiroptical and photophysical properties of the resulting neutral or cationic complexes, leading to the first examples of rhenium-based phosphors that exhibit circularly polarized luminescence.

  7. Catalytic Activity of Platinum Monolayer on Iridium and Rhenium Alloy Nanoparticles for the Oxygen Reduction Reaction

    SciTech Connect

    Karan, Hiroko I.; Sasaki, Kotaro; Kuttiyiel, Kurian; Farberow, Carrie A.; Mavrikakis, Manos; Adzic, Radoslav R.

    2012-05-04

    A new type of electrocatalyst with a core–shell structure that consists of a platinum monolayer shell placed on an iridium–rhenium nanoparticle core or platinum and palladium bilayer shell deposited on that core has been prepared and tested for electrocatalytic activity for the oxygen reduction reaction. Carbon-supported iridium–rhenium alloy nanoparticles with several different molar ratios of Ir to Re were prepared by reducing metal chlorides dispersed on Vulcan carbon with hydrogen gas at 400 °C for 1 h. These catalysts showed specific electrocatalytic activity for oxygen reduction reaction comparable to that of platinum. The activities of PtML/PdML/Ir2Re1, PtML/Pd2layers/Ir2Re1, and PtML/Pd2layers/Ir7Re3 catalysts were, in fact, better than that of conventional platinum electrocatalysts, and their mass activities exceeded the 2015 DOE target. Our density functional theory calculations revealed that the molar ratio of Ir to Re affects the binding strength of adsorbed OH and, thereby, the O2 reduction activity of the catalysts. The maximum specific activity was found for an intermediate OH binding energy with the corresponding catalyst on the top of the volcano plot. The monolayer concept facilitates the use of much less platinum than in other approaches. Finally, the results with the PtML/PdML/Ir2Re electrocatalyst indicate that it is a promising alternative to conventional Pt electrocatalysts in low-temperature fuel cells.

  8. Effect of rhenium addition on tungsten fuzz formation in helium plasmas

    NASA Astrophysics Data System (ADS)

    Khan, Aneeqa; De Temmerman, Gregory; Morgan, Thomas W.; Ward, Michael B.

    2016-06-01

    The effect of the addition of rhenium to tungsten on the formation of a nanostructure referred to as 'fuzz' when exposed to helium plasmas at fusion relevant ion fluxes was investigated in the Magnum and Pilot PSI devices at the FOM Institute DIFFER. The effect rhenium had on fuzz growth was seen to be dependent on time, temperature and flux. Initial fuzz growth was seen to be highly dependent on grain orientation, with rhenium having little effect. Once the fuzz was fully developed, the effect of grain orientation disappeared and the rhenium had an inhibiting effect on growth. This could be beneficial for inhibiting fuzz growth in a future fusion reactor, where transmutation of tungsten to rhenium is expected. It also appears that erosion or annealing of the fuzz is limiting growth of fuzz at higher temperatures in the range of ∼1340 °C.

  9. Spectroscopic Characterization of a Monomeric, Cyclopentadienyl-Based Rhenium(V) Dioxo Complex.

    PubMed

    Raju, Suresh; Jastrzebski, Johann T B H; Lutz, Martin; Witteman, Léon; Dethlefsen, Johannes R; Fristrup, Peter; Moret, Marc-Etienne; Gebbink, Robertus J M Klein

    2015-11-16

    Mononuclear, coordinatively unsaturated rhenium(V) dioxo species of the type XReO2 (X = Me, substituted cyclopentadienyl) have long been postulated as intermediates in rhenium-catalyzed deoxydehydration, but their characterization was precluded because of aggregation into dimeric or oligomeric structures. Using the bulky 1,2,4-tri-tert-butylcyclopentadienyl (Cp(ttt)) ligand, the rhenium(V) dioxo species (Cp(ttt))ReO2 could now be observed, in equilibrium with the dimeric form [(Cp(ttt))Re(O)μ-O]2, and characterized by NMR, IR, and UV-vis spectroscopies, as well as electrospray ionization mass spectrometry. (Cp(ttt))ReO2 is shown to be the primary product of reduction of the rhenium(VII) complex (Cp(ttt))ReO3 with PPh3 and demonstrated to react with ethylene glycol significantly faster than its dimeric counterpart, supporting its role as an intermediate in rhenium-catalyzed deoxydehydration reactions.

  10. Atom Probe Tomography Analysis of the Distribution of Rhenium in Nickel Alloys

    SciTech Connect

    Mottura, A.; Warnken, N; Miller, Michael K; Reed, R. C.; Finnis, M.

    2010-01-01

    Atom probe tomography (APT) is used to characterise the distributions of rhenium in a binary Ni-Re alloy and the nickel-based single-crystal CMSX-4 superalloy. A purpose-built algorithm is developed to quantify the size distribution of solute clusters, and applied to the APT datasets to critique the hypothesis that rhenium is prone to the formation of clusters in these systems. No evidence is found to indicate that rhenium forms solute clusters above the level expected from random fluctuations. In CMSX-4, enrichment of Re is detected in the matrix phase close to the matrix/precipitate ({gamma}/{gamma}{prime}) phase boundaries. Phase field modelling indicates that this is due to the migration of the {gamma}/{gamma}{prime} interface during cooling from the temperature of operation. Thus, neither clustering of rhenium nor interface enrichments can be the cause of the enhancement in high temperature mechanical properties conferred by rhenium alloying.

  11. Intraarterial irradiation with rhenium-188 for inhibition of restenosis after PTCA - strategy and evaluation of Re-188-species for rapid urinary excretion

    SciTech Connect

    Knapp, F.F. Jr.; Guhlke, S.; Beets, A.L.

    1997-05-01

    Estimated costs for coronary restenosis therapy after PTCA are > $ 1 billion (U.S.). Radiation is a simple and effective tool for inhibition of neointimal proliferation an important component of restenosis. We propose use of Re-188 (t{sub {1/2}} 16.9 h, 2.1 MeV {beta}), obtained from decay of W-188 (T{sub {1/2}} 69 d). Our alumina-based W-188/Re-188 generator has a shelf-life of several months and we have developed an on-line tandem cation/anion exchange column system to concentrate to > 18.5 BGq/mL. Estimates for targeted regional dose of 8.4 rad/37 MBq/min/mL, which is > 1,400 cGy for about 370 MBq Re-188 for 5 min. Balloon inflation with Re-188 solutions is a new approach for more uniform vascular dose distribution as an alternative to use of radioactive wires or other linear sources. Rapid urinary excretion kinetics are important in the unlikely event of balloon rupture (<0.1%). We have therefore evaluated relative excretion kinetics of Re-188-perrhenate and -MAG3 in rats; Re-188-perrhenate was obtained from generator elution with 0.9% NaCl and re-188-MAG3 was prepared be reaction of the ligand with Sn(II)-reduced perrhenate. Fischer rats (n=4-5/group) were injected i.v. and urine and feces collected every 2 h for 12 h and then daily for 5 d. Both agents excreted > 90% in urine; biodistribution studies showed low organ uptake with intestines as the major site. Rhenium-188-MAG3 excreted more rapidly (2 h = 59.6{+-}18.5%) then Re-188-MAG3 excreted more rapidly (2 h = 68.3{+-}13.5%) in same model. Both Re-188 species are thus good candidates for balloon inflation. Studies are in progress in a swine model to evaluate the effectiveness of Re-188 for inhibition of restenosis.

  12. 40 CFR 98.185 - Procedures for estimating missing data.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Procedures for estimating missing data. 98.185 Section 98.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... accounting purposes (such as purchase records)....

  13. 40 CFR 98.185 - Procedures for estimating missing data.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Procedures for estimating missing data. 98.185 Section 98.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... accounting purposes (such as purchase records)....

  14. 5 CFR 185.115 - Separation of functions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Separation of functions. 185.115 Section 185.115 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.115 Separation of functions. (a) The investigating official, the...

  15. 5 CFR 185.115 - Separation of functions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Separation of functions. 185.115 Section 185.115 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.115 Separation of functions. (a) The investigating official, the...

  16. 5 CFR 185.115 - Separation of functions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Separation of functions. 185.115 Section 185.115 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.115 Separation of functions. (a) The investigating official, the...

  17. 5 CFR 185.115 - Separation of functions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Separation of functions. 185.115 Section 185.115 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.115 Separation of functions. (a) The investigating official, the...

  18. 5 CFR 185.115 - Separation of functions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Separation of functions. 185.115 Section 185.115 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.115 Separation of functions. (a) The investigating official, the...

  19. 46 CFR 185.506 - Passenger safety orientation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Passenger safety orientation. 185.506 Section 185.506... TONS) OPERATIONS Preparations for Emergencies § 185.506 Passenger safety orientation. (a) Except as... informed of the required safety information. (e) On a vessel on a voyage of more than 24 hours...

  20. 46 CFR 185.516 - Life jacket placards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Life jacket placards. 185.516 Section 185.516 Shipping...) OPERATIONS Preparations for Emergencies § 185.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous...

  1. 46 CFR 185.516 - Life jacket placards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Life jacket placards. 185.516 Section 185.516 Shipping...) OPERATIONS Preparations for Emergencies § 185.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous...

  2. 46 CFR 185.516 - Life jacket placards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Life jacket placards. 185.516 Section 185.516 Shipping...) OPERATIONS Preparations for Emergencies § 185.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous...

  3. 46 CFR 185.502 - Crew and passenger list.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Crew and passenger list. 185.502 Section 185.502 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.502 Crew and passenger list. (a) The...

  4. 46 CFR 185.502 - Crew and passenger list.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Crew and passenger list. 185.502 Section 185.502 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.502 Crew and passenger list. (a) The...

  5. 46 CFR 185.502 - Crew and passenger list.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Crew and passenger list. 185.502 Section 185.502 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.502 Crew and passenger list. (a) The...

  6. 46 CFR 185.502 - Crew and passenger list.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Crew and passenger list. 185.502 Section 185.502 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.502 Crew and passenger list. (a) The...

  7. 46 CFR 185.502 - Crew and passenger list.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Crew and passenger list. 185.502 Section 185.502 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.502 Crew and passenger list. (a) The...

  8. 46 CFR 185.604 - Lifesaving equipment markings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Lifesaving equipment markings. 185.604 Section 185.604 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Markings Required § 185.604 Lifesaving equipment markings. (a) The name of a vessel must be marked or painted in...

  9. 32 CFR 185.2 - Applicability and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Applicability and scope. 185.2 Section 185.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.2 Applicability and scope. This part: (a) Applies to the Office of...

  10. 32 CFR 185.2 - Applicability and scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Applicability and scope. 185.2 Section 185.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.2 Applicability and scope. This part: (a) Applies to the Office of...

  11. 5 CFR 185.129 - Computation of time.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Computation of time. 185.129 Section 185.129 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.129 Computation of time. (a) In computing any period of time under this part or in an order issued thereunder, the time...

  12. 5 CFR 185.129 - Computation of time.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Computation of time. 185.129 Section 185.129 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.129 Computation of time. (a) In computing any period of time under this part or...

  13. 46 CFR 185.524 - Fire fighting drills and training.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fire fighting drills and training. 185.524 Section 185... 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.524 Fire fighting drills and training. (a) The master shall conduct sufficient fire drills to make sure that each crew member is...

  14. 46 CFR 185.524 - Fire fighting drills and training.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Fire fighting drills and training. 185.524 Section 185... 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.524 Fire fighting drills and training. (a) The master shall conduct sufficient fire drills to make sure that each crew member is...

  15. 46 CFR 185.524 - Fire fighting drills and training.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fire fighting drills and training. 185.524 Section 185... 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.524 Fire fighting drills and training. (a) The master shall conduct sufficient fire drills to make sure that each crew member is...

  16. 46 CFR 185.524 - Fire fighting drills and training.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fire fighting drills and training. 185.524 Section 185... 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.524 Fire fighting drills and training. (a) The master shall conduct sufficient fire drills to make sure that each crew member is...

  17. 46 CFR 185.524 - Fire fighting drills and training.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fire fighting drills and training. 185.524 Section 185... 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.524 Fire fighting drills and training. (a) The master shall conduct sufficient fire drills to make sure that each crew member is...

  18. 5 CFR 185.136 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Post-hearing briefs. 185.136 Section 185... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing...

  19. 46 CFR 185.608 - Fuel shutoff valves.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fuel shutoff valves. 185.608 Section 185.608 Shipping...) OPERATIONS Markings Required § 185.608 Fuel shutoff valves. Remote fuel shutoff stations must be marked in clearly legible letters at least 25 millimeters (1 inch) high indicating purpose of the valve...

  20. 46 CFR 185.608 - Fuel shutoff valves.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fuel shutoff valves. 185.608 Section 185.608 Shipping...) OPERATIONS Markings Required § 185.608 Fuel shutoff valves. Remote fuel shutoff stations must be marked in clearly legible letters at least 25 millimeters (1 inch) high indicating purpose of the valve...

  1. 46 CFR 185.704 - Maintenance of falls.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Maintenance of falls. 185.704 Section 185.704 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Operational Readiness, Maintenance, and Inspection of Lifesaving Equipment § 185.704...

  2. 46 CFR 185.360 - Use of auto pilot.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Use of auto pilot. 185.360 Section 185.360 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Miscellaneous Operating Requirements § 185.360 Use of auto pilot. Whenever an automatic pilot...

  3. 46 CFR 185.340 - Vessels carrying vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Vessels carrying vehicles. 185.340 Section 185.340... TONS) OPERATIONS Miscellaneous Operating Requirements § 185.340 Vessels carrying vehicles. (a) Automobiles or other vehicles must be stowed in such a manner as to permit both passengers and crew to get...

  4. 46 CFR 185.203 - Notice of hazardous conditions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Notice of hazardous conditions. 185.203 Section 185.203 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Marine Casualties and Voyage Records § 185.203 Notice of hazardous...

  5. 46 CFR 185.518 - Inflatable survival craft placards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Inflatable survival craft placards. 185.518 Section 185... 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.518 Inflatable survival craft placards. (a) Every vessel equipped with an inflatable survival craft must have approved placards or...

  6. 46 CFR 185.360 - Use of auto pilot.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Use of auto pilot. 185.360 Section 185.360 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Miscellaneous Operating Requirements § 185.360 Use of auto pilot. Whenever an automatic pilot...

  7. 46 CFR 185.720 - Weekly maintenance and inspections.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Weekly maintenance and inspections. 185.720 Section 185... 100 GROSS TONS) OPERATIONS Operational Readiness, Maintenance, and Inspection of Lifesaving Equipment § 185.720 Weekly maintenance and inspections. The following tests and inspections must be carried...

  8. 46 CFR 172.185 - Permeability of spaces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Permeability of spaces. 172.185 Section 172.185 Shipping... Under Subchapter O of This Chapter § 172.185 Permeability of spaces. (a) When doing the calculations required in § 172.170, the permeability of a floodable space other than a machinery space must be as...

  9. 5 CFR 185.129 - Computation of time.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Computation of time. 185.129 Section 185.129 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.129 Computation of time. (a) In computing any period of time under this part or...

  10. 46 CFR 185.516 - Life jacket placards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Life jacket placards. 185.516 Section 185.516 Shipping...) OPERATIONS Preparations for Emergencies § 185.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous...

  11. 46 CFR 185.516 - Life jacket placards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Life jacket placards. 185.516 Section 185.516 Shipping...) OPERATIONS Preparations for Emergencies § 185.516 Life jacket placards. (a) Placards containing instructions for the donning and use of the life jackets aboard the vessel must be posted in conspicuous...

  12. 46 CFR 185.508 - Wearing of life jackets.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Wearing of life jackets. 185.508 Section 185.508... TONS) OPERATIONS Preparations for Emergencies § 185.508 Wearing of life jackets. (a) The master of a vessel shall require passengers to don life jackets when possible hazardous conditions exist,...

  13. 46 CFR 185.508 - Wearing of life jackets.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Wearing of life jackets. 185.508 Section 185.508... TONS) OPERATIONS Preparations for Emergencies § 185.508 Wearing of life jackets. (a) The master of a vessel shall require passengers to don life jackets when possible hazardous conditions exist,...

  14. 5 CFR 185.144 - Right to administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Right to administrative offset. 185.144 Section 185.144 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.144 Right to administrative offset. The amount of any penalty or...

  15. 46 CFR 185.206 - Written report of marine casualty.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Written report of marine casualty. 185.206 Section 185... 100 GROSS TONS) OPERATIONS Marine Casualties and Voyage Records § 185.206 Written report of marine... of any marine casualty. This written report is in addition to the immediate notice required by...

  16. 5 CFR 185.136 - Post-hearing briefs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Post-hearing briefs. 185.136 Section 185... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing...

  17. 5 CFR 185.136 - Post-hearing briefs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Post-hearing briefs. 185.136 Section 185... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing...

  18. 5 CFR 185.136 - Post-hearing briefs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Post-hearing briefs. 185.136 Section 185... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing...

  19. 46 CFR 185.208 - Accidents to machinery.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Accidents to machinery. 185.208 Section 185.208 Shipping...) OPERATIONS Marine Casualties and Voyage Records § 185.208 Accidents to machinery. The owner, managing operator, or master shall report damage to a boiler, unfired pressure vessel, or machinery that...

  20. 21 CFR 73.185 - Haematococcus algae meal.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Haematococcus algae meal. 73.185 Section 73.185... COLOR ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.185 Haematococcus algae meal. (a) Identity. (1) The color additive haematococcus algae meal consists of the comminuted and dried cells of the...

  1. 21 CFR 73.185 - Haematococcus algae meal.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Haematococcus algae meal. 73.185 Section 73.185... COLOR ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.185 Haematococcus algae meal. (a) Identity. (1) The color additive haematococcus algae meal consists of the comminuted and dried cells of the...

  2. 21 CFR 73.185 - Haematococcus algae meal.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Haematococcus algae meal. 73.185 Section 73.185... COLOR ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.185 Haematococcus algae meal. (a) Identity. (1) The color additive haematococcus algae meal consists of the comminuted and dried cells of the...

  3. 21 CFR 73.185 - Haematococcus algae meal.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Haematococcus algae meal. 73.185 Section 73.185... COLOR ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.185 Haematococcus algae meal. (a) Identity. (1) The color additive haematococcus algae meal consists of the comminuted and dried cells of the...

  4. 21 CFR 73.185 - Haematococcus algae meal.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Haematococcus algae meal. 73.185 Section 73.185... COLOR ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.185 Haematococcus algae meal. (a) Identity. (1) The color additive haematococcus algae meal consists of the comminuted and dried cells of the...

  5. 46 CFR 172.185 - Permeability of spaces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Permeability of spaces. 172.185 Section 172.185 Shipping... Under Subchapter O of This Chapter § 172.185 Permeability of spaces. (a) When doing the calculations required in § 172.170, the permeability of a floodable space other than a machinery space must be as...

  6. 46 CFR 172.185 - Permeability of spaces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Permeability of spaces. 172.185 Section 172.185 Shipping... Under Subchapter O of This Chapter § 172.185 Permeability of spaces. (a) When doing the calculations required in § 172.170, the permeability of a floodable space other than a machinery space must be as...

  7. 46 CFR 172.185 - Permeability of spaces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Permeability of spaces. 172.185 Section 172.185 Shipping... Under Subchapter O of This Chapter § 172.185 Permeability of spaces. (a) When doing the calculations required in § 172.170, the permeability of a floodable space other than a machinery space must be as...

  8. 46 CFR 185.608 - Fuel shutoff valves.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fuel shutoff valves. 185.608 Section 185.608 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Markings Required § 185.608 Fuel shutoff valves. Remote fuel shutoff stations must be marked...

  9. 46 CFR 185.608 - Fuel shutoff valves.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fuel shutoff valves. 185.608 Section 185.608 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Markings Required § 185.608 Fuel shutoff valves. Remote fuel shutoff stations must be marked...

  10. Ultra-small rhenium clusters supported on graphene

    PubMed Central

    Miramontes, Orlando; Bonafé, Franco; Santiago, Ulises; Larios-Rodriguez, Eduardo; Velázquez-Salazar, Jesús J.; Mariscal, Marcelo M.; Yacaman, Miguel José

    2015-01-01

    The adsorption of very small rhenium clusters (2 – 13 atoms) supported on graphene was studied with high annular dark field - scanning transmission electron microscopy (HAADF-STEM). The atomic structure of the clusters was fully resolved with the aid of density functional calculations and STEM simulations. It was found that octahedral and tetrahedral structures work as seeds to obtain more complex morphologies. Finally, a detailed analysis of the electronic structure suggested that a higher catalytic effect can be expected in Re clusters when adsorbed on graphene than in isolated ones. PMID:25721176

  11. Preparation and properties of polytetrafluoroethylene impregnated with rhenium oxides

    NASA Technical Reports Server (NTRS)

    Leibecki, H. F.; Easter, R. W.

    1973-01-01

    The results of tests carried out to determine the properties of polytetrafluorethylene (PTFE) impregnated with rhenium oxides are presented. The tests included measurement of physical properties of the impregnated material and investigation of the effects of preparation process variables. Based on the latter tests a mechanism to describe the permeation process is postulated which identifies the rate controlling step to be diffusion of ReF6 molecules into the solid during the initial ReF6 soak. Physical property tests indicated that the electronic conductance is increased by many orders of magnitude while the desirable properties of the PTFE remain virtually unchanged.

  12. Ultra-small rhenium clusters supported on graphene.

    PubMed

    Miramontes, Orlando; Bonafé, Franco; Santiago, Ulises; Larios-Rodriguez, Eduardo; Velázquez-Salazar, Jesús J; Mariscal, Marcelo M; Yacaman, Miguel José

    2015-03-28

    The adsorption of very small rhenium clusters (2-13 atoms) supported on graphene was studied by high-angle annular dark field-scanning transmission electron microscopy (HAADF-STEM). The atomic structure of the clusters was fully resolved with the aid of density functional theory calculations and STEM simulations. It was found that octahedral and tetrahedral structures work as seeds to obtain more complex morphologies. Finally, a detailed analysis of the electronic structure suggested that a higher catalytic effect can be expected in Re clusters when adsorbed on graphene than in isolated ones.

  13. Functionalization of Rhenium Aryl Bonds by O-Atom Transfer

    SciTech Connect

    Bischof, Steven M.; Cheng, Mu-Jeng; Nielsen, Robert J.; Gunnoe, T. Brent; Goddard, William A.; Periana, Roy A.

    2011-03-29

    Aryltrioxorhenium (ArReO3) has been demonstrated to show rapid oxy-functionalization upon reaction with O-atom donors, YO, to selectively generate the corresponding phenols in near quantitative yields. 18O-Labeling experiments show that the oxygen in the products is exclusively from YO. DFT studies reveal a 10.7 kcal/mol barrier (Ar = Ph) for oxy-functionalization with H2O2 via a Baeyer-Villiger type mechanism involving nucleophilic attack of the aryl group on an electrophilic oxygen of YO coordinated to rhenium.

  14. RHENIUM SOLUBILITY IN BOROSILICATE NUCLEAR WASTE GLASS IMPLICATIONS FOR THE PROCESSING AND IMMOBILIZATION OF TECHNETIUM-99 (AND SUPPORTING INFORMATION WITH GRAPHICAL ABSTRACT)

    SciTech Connect

    AA KRUGER; A GOEL; CP RODRIGUEZ; JS MCCLOY; MJ SCHWEIGER; WW LUKENS; JR, BJ RILEY; D KIM; M LIEZERS; P HRMA

    2012-08-13

    The immobilization of 99Tc in a suitable host matrix has proved a challenging task for researchers in the nuclear waste community around the world. At the Hanford site in Washington State in the U.S., the total amount of 99Tc in low-activity waste (LAW) is {approx} 1,300 kg and the current strategy is to immobilize the 99Tc in borosilicate glass with vitrification. In this context, the present article reports on the solubility and retention of rhenium, a nonradioactive surrogate for 99Tc, in a LAW sodium borosilicate glass. Due to the radioactive nature of technetium, rhenium was chosen as a simulant because of previously established similarities in ionic radii and other chemical aspects. The glasses containing target Re concentrations varying from 0 to10,000 ppm by mass were synthesized in vacuum-sealed quartz ampoules to minimize the loss of Re by volatilization during melting at 1000 DC. The rhenium was found to be present predominantly as Re7 + in all the glasses as observed by X-ray absorption near-edge structure (XANES). The solubility of Re in borosilicate glasses was determined to be {approx}3,000 ppm (by mass) using inductively coupled plasma-optical emission spectroscopy (ICP-OES). At higher rhenium concentrations, some additional material was retained in the glasses in the form of alkali perrhenate crystalline inclusions detected by X-ray diffraction (XRD) and laser ablation-ICP mass spectrometry (LA-ICP-MS). Assuming justifiably substantial similarities between Re7 + and Tc 7+ behavior in this glass system, these results implied that the processing and immobilization of 99Tc from radioactive wastes should not be limited by the solubility of 99Tc in borosilicate LAW glasses.

  15. Optical and chemical properties of mixed-valent rhenium oxide films synthesized by reactive DC magnetron sputtering

    NASA Astrophysics Data System (ADS)

    Murphy, Neil R.; Gallagher, Regina C.; Sun, Lirong; Jones, John G.; Grant, John T.

    2015-07-01

    Mixed-valent rhenium oxide thin films were deposited using reactive magnetron sputtering employing a metallic rhenium target within an oxygen-argon environment. The oxygen and argon flow rates were systematically varied, while the extinction coefficient, k, of the deposited layers was monitored using in situ spectroscopic ellipsometry. In situ monitoring was used to identify absorption features specific to ReO3, namely, the minimization of k brought on by the gap between interband absorption features in the UV at 310 nm and the onset of free electron absorption at wavelengths above 540 nm. Based on these results, oxygen flow ratios of 50% and 60% were shown to produce films having optical properties characteristic of ReO3, and thus, were selected for detailed ex situ characterization. Chemical analysis via X-ray photoelectron spectroscopy confirmed that all films consisted largely of ReO3, but had some contributions from Re2O3, ReO2 and Re2O7. Additional monitoring of the chemistry, as a function of environmental exposure time, indicated a correlation between structural instability and the presence of Re2O3 and Re2O7 in the films.

  16. Rhenium-187 and the age of the galaxy

    SciTech Connect

    Bosch, Fritz

    1999-06-11

    The amount of {sup 187}Os in meteorites resulting from beta decay of the long-lived {sup 187}Re nuclide has been used as a measure of the time span of nucleosynthesis in our galaxy. During the galactic history, however, the rhenium atoms can be 'astrated' several times into newly forming stars, where they are stripped of most or all of their electrons. An experiment conducted at the ion storage ring ESR at Darmstadt showed that for bare {sup 187}Re ions, the lifetime is shortened by more than nine orders of magnitude. This observation strongly suggests that the effective lifetime of {sup 187}Re during the galactic evolution might differ significantly from the lifetime of neutral {sup 187}Re. Furthermore, it enables a recalibration of the rhenium aeon clock in the framework of chemical-evolution models of our galaxy. Based on this new calibration, a preliminary lower limit of 12x10{sup 9} yr for the age of our galaxy has been derived, which is, a fortiori, also a lower limit for the age of the universe. In combination with the Hubble constant, this limit provides narrow constraints for actual cosmological models.

  17. Redox reactivity of mononuclear and binuclear rhenium complexes

    SciTech Connect

    Holder, G.N.

    1988-01-01

    Six different classes of monomeric and dimeric rhenium complexes containing substituted nitriles, substituted pyridines, dithiocarbamates, and substituted phosphines as ligands were synthesized. Monomers had the general formula ReCl{sub 3} (NCR) (PPh{sub 3}){sub 2}, ReCl{sub 3}-(NCCH{sub 3})(P-(aryl-R){sub 3}){sub 2}, and ReOCl{sub 3} (P-(aryl-R){sub 3}){sub 2}. Dimers had the general formula Re{sub 2}Cl{sub 4} (dppm){sub 2} (NCR) and (Re{sub 2}Cl{sub 3}(dppm){sub 2}-(NCR){sub 2}){sup +} (dppm = bis(diphenylphosphino)methane) and Re{sub 2}O{sub 3}Cl{sub 4}-(py){sub 4}, where R was an alkyl or halogenated substituent chosen to systematically vary the donor-acceptor properties of the nitrile, pyridine, or phosphine ligand. The effects of this structural change on the function of the molecule was monitored both spectrally and electrochemically. Rate constants for addition of nitriles to the metal-metal bridged dimeric complex were found to vary linearly with the identity of the substitutent. Spectroscopic data followed these trends as well. The structure-function relationships derived from this work will aid in the design of future Technetium and Rhenium-based organ selective radioimaging agents.

  18. Fluorescent rhenium-naphthalimide conjugates as cellular imaging agents.

    PubMed

    Langdon-Jones, Emily E; Symonds, Nadine O; Yates, Sara E; Hayes, Anthony J; Lloyd, David; Williams, Rebecca; Coles, Simon J; Horton, Peter N; Pope, Simon J A

    2014-04-01

    A range of biologically compatible, fluorescent rhenium-naphthalimide conjugates, based upon the rhenium fac-tricarbonyl core, has been synthesized. The fluorescent ligands are based upon a N-functionalized, 4-amino-derived 1,8-naphthalimide core and incorporate a dipicolyl amine binding unit to chelate Re(I); the structural variations accord to the nature of the alkylated imide with ethyl ester glycine (L(1)), 3-propanol (L(2)), diethylene glycol (L(3)), and benzyl alcohol (L(4)) variants. The species are fluorescent in the visible region between 505 and 537 nm through a naphthalimide-localized intramolecular charge transfer, with corresponding fluorescent lifetimes of up to 9.8 ns. The ligands and complexes were investigated for their potential as imaging agents for human osteoarthritic cells and protistan fish parasite Spironucleus vortens using confocal fluorescence microscopy. The results show that the specific nature of the naphthalimide structure serves to control the uptake and intracellular localization of these imaging agents. Significant differences were noted between the free ligands and complexes, with the Re(I) complex of L(2) showing hydrogenosomal localization in S. vortens.

  19. The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.

    PubMed

    Houghton, Fiona J; Chew, Pau Ling; Lodeho, Sylvain; Goud, Bruno; Gleeson, Paul A

    2009-08-21

    Mammalian golgins of the trans-Golgi network (TGN) are small G protein effectors that are required for membrane transport and contain a Golgi targeting C-terminal GRIP domain. The localization of two TGN golgins, p230/golgin-245 and golgin-97, is mediated by the small GTPase Arl1, whereas recruitment of the TGN golgin GCC185 is controversial. Recently, GCC185 was proposed to localize to the Golgi by the co-operation of two small GTPases, Rab6A/A' and Arl1 (Burguete et al., 2008), a model based predominantly on in vitro interactions. Here we demonstrate that Golgi recruitment of endogenous GCC185 does not involve Rab6A/A' and Arl1. We find minimal colocalization between Rab6A/A' and endogenous GCC185 on Golgi membranes and failed to detect an interaction between Rab6A/A' and C-terminal domains of GCC185 by yeast two-hybrid analyses. Moreover, depletion of both Rab6A/A' and Arl1 also had no effect on the localization of endogenous GCC185 or the isolated GRIP domain of GCC185.

  20. Nickel-rhenium compound sheds light on the potency of rhenium as a strengthener in high-temperature nickel alloys

    NASA Astrophysics Data System (ADS)

    Maisel, Sascha B.; Schindzielorz, Nils; Mottura, Alessandro; Reed, Roger C.; Müller, Stefan

    2014-09-01

    For many decades, it has been known that rhenium imparts a tremendous resistance to creep to the nickel-based high-temperature alloys colloquially known as superalloys. This effect is so pronounced that is has been dubbed "the rhenium effect." Its origins are ill-understood, even though it is so critical to the performance of these high-temperature alloys. In this paper we show that the currently known phase diagram is inaccurate, and neglects a stoichiometric compound at 20 at.% Re (Nimathvariant="bold">4Re). The presence of this precipitate at low temperatures and the short-range ordering of Re in fcc-Ni observed at higher temperatures have important ramifications for the Ni-based superalloys. The Nimathvariant="bold">4Re compound is shown to be stable by quantum mechanical high-throughput calculations at 0 K. Monte Carlo simulations show that it is thermally persistent up to ≈930 K when considering configurational entropy. The existence of this compound is investigated using extended x-ray absorption fine spectroscopy on a Ni96.62Re3.38 alloy.

  1. Determination of the magnitude and sign of the 185,187Re nuclear electric quadrupole coupling constants using nuclear acoustic resonance

    NASA Astrophysics Data System (ADS)

    Sundfors, R. K.

    1990-08-01

    Acoustic nuclear electric quadrupole resonance spectra and the magnitude and sign of the coupling constants for 185Re and 187Re in rhenium-metal single crystals have been measured using nuclear acoustic resonance (NAR) in a small magnetic field. These measurements were carried out using a NAR reflection bridge spectrometer in the 37-41 MHz frequency range and at 4.2 and 77.8 K. In this hexagonal crystal, the dynamic coupling between acoustic waves and the Re nuclear spin systems is shown to be via the dynamic quadrupole interaction, which is responsible for the observation of both Δm=+/-1 and +/-2 transitions between the +/-3/2 energy levels and the mixed +/-1/2 energy levels. Magnetic-resonance second moments for angular-independent indirect exchange broadening and angular-dependent static electric quadrupole broadening (from a spread in the electric quadrupole coupling constant value) are determined from the measured linewidths.

  2. Preliminary evidence of field induced rhenium etching by XeF2 at high vacuum

    NASA Astrophysics Data System (ADS)

    Castano Giraldo, C. H.; Aghazarian, M.; Ruzic, D. N.

    2008-02-01

    Preliminary evidence of enhanced etching of rhenium by XeF2 under the influence of an electric field (3.36GV /m) is presented. Scanning electron microscope photographs of sharp rhenium tips show etching of at least 0.40μm ±0.07 in 32min at the point of maximum electric field, indicating a field enhanced etching rate of 13nm/min ±2. A control experiment shows a maximum spontaneous etching of rhenium by XeF2 of 0.1μm ±0.07 in 30min, indicating a maximum possible spontaneous etching rate of rhenium by XeF2 of 3nm /min ±2. The spontaneous rate of tungsten by XeF2 reported in the literature is 0.2nm /min.

  3. Development of Improved Rhenium Coatings for Fluorine Engine Thrust Chambers. [hydrazine-fluorine rocket engines

    NASA Technical Reports Server (NTRS)

    Barton, K. J.; Yurkewycz, R.; Harada, Y.; Daniels, I.

    1981-01-01

    Coating trials were undertaken to evaluate the application of rhenium to carbon-carbon composite sheet by plasma spraying. Optimum spray parameters and coating thickness were identified for production of coatings free from continuous defects and with adequate adherence to the substrate. A tungsten underlayer was not beneficial and possibly detracted from coating integrity. Stress calculations indicated that the proposed operating cycle of the rocket engine would not cause spalling of the rhenium coating. Calculations indicated that permeation of gases through the coating would not be significant during the expected life of the thrust chamber. The feasibility of applying rhenium coatings by laser melting was also studied. Poor wetting of the composite surface by the liquid rhenium precluded production of uniform coatings. Borate/carborate fluxes did not improve wetting characteristics.

  4. Mechanistic insights into the rhenium-catalyzed alcohol-to-olefin dehydration reaction.

    PubMed

    Korstanje, Ties J; Jastrzebski, Johann T B H; Klein Gebbink, Robertus J M

    2013-09-23

    Rhenium-based complexes are powerful catalysts for the dehydration of various alcohols to the corresponding olefins. Here, we report on both experimental and theoretical (DFT) studies into the mechanism of the rhenium-catalyzed dehydration of alcohols to olefins in general, and the methyltrioxorhenium-catalyzed dehydration of 1-phenylethanol to styrene in particular. The experimental and theoretical studies are in good agreement, both showing the involvement of several proton transfers, and of a carbenium ion intermediate in the catalytic cycle.

  5. Spectrophotometric catalytic determination of small amounts of rhenium in mineralized rocks and molybdenite

    USGS Publications Warehouse

    Simon, F.O.; Grimaldi, F.S.

    1962-01-01

    Rhenium is determined by spectrophotometry of the tellurium sol formed by the reduction of tellurate by stannous chloride under the catalytic influence of rhenium. A detailed investigation of the conditions for high sensitivity and stability at lowest concentration levels of rhenium is presented as well as the behavior of 26 ions. The method is applied to the determination of some tenths of 1 p.p.m. or more of rhenium in a 1-mg. aliquot of mineralized rocks, mixtures of molybdenite and rocks, and molybdenite concentrates. The practical quantity limit of detection is 2 ?? 10-10 gram of rhenium. Samples are decomposed with a mixture of CaO, CaCl2, and MgO. On leaching, most constituents of the sample are precipitated either as calcium salts or hydroxides, except for rhenium and a small amount of molybdenum which pass into the filtrate. Residual molybdenum is removed by extraction with 8-quinolinol in chloroform. Better than 95% recoveries are obtained with two fusions with flux.

  6. Separation of rhenium from molybdenum, tungsten, vanadium, platinum metals and other elements by reduction and solvent extraction.

    PubMed

    Yatirajam, V; Kakkar, L R

    1970-08-01

    Reduction in 1 M H(2)SO(4) with liquid zinc amalgam and extraction with isopentanol from 3M H(2)SO(4), separates rhenium from almost all the interfering elements of importance in rhenium determination. The small amounts of Mo, U, Fe and Ru still accompanying rhenium are removed by the thiocyanate-pentyl acetate or the oxine-chloroform extraction. The method is simple, rapid and of very wide applicability. It is particularly useful in the determination of rhenium in various alloys and tungsten-containing samples. PMID:18960795

  7. Nitrogen concentration driving the hardness of rhenium nitrides

    PubMed Central

    Zhao, Zhonglong; Bao, Kuo; Li, Da; Duan, Defang; Tian, Fubo; Jin, Xilian; Chen, Changbo; Huang, Xiaoli; Liu, Bingbing; Cui, Tian

    2014-01-01

    The structures and properties of rhenium nitrides are studied with density function based first principle method. New candidate ground states or high-pressure phases at Re:N ratios of 3:2, 1:3, and 1:4 are identified via a series of evolutionary structure searches. We find that the 3D polyhedral stacking with strong covalent N-N and Re-N bonding could stabilize Re nitrides to form nitrogen rich phases, meanwhile, remarkably improve the mechanical performance than that of sub-nitrides, as Re3N, Re2N, and Re3N2. By evaluating the trends of the crystal configuration, electronic structure, elastic properties, and hardness as a function of the N concentration, we proves that the N content is the key factor affecting the metallicity and hardness of Re nitrides. PMID:24762713

  8. Lattice Dynamics of the Rhenium and Technetium Dichalcogenides.

    PubMed

    Wolverson, Daniel; Hart, Lewis S

    2016-12-01

    The rhenium and technetium dichalcogenides are layered van der Waals semiconductors which show a large number of Raman-active zone-centre phonon modes as a result of their unusually large unit cells and deviation from hexagonal symmetry. They thus offer the possibility of introducing in-plane anisotropy into composite heterostructures based on van der Waals materials, and Raman spectroscopy is generally used to determine their in-plane orientation. We show that first-principles calculations give a good description of the lattice dynamics of this family of materials and thus predict the zone-centre phonon frequencies and Raman activities of TcS2. We consider the distribution of the phonon modes in frequency and their atomic displacements and give a unified understanding of the phonon frequencies and Raman spectra of ReS2, TcS2 and ReSe2 in terms of the scaling of Raman frequency with the chalcogen mass. PMID:27178055

  9. Organometallic Rhenium Complexes Divert Doxorubicin to the Mitochondria.

    PubMed

    Imstepf, Sebastian; Pierroz, Vanessa; Rubbiani, Riccardo; Felber, Michael; Fox, Thomas; Gasser, Gilles; Alberto, Roger

    2016-02-18

    Doxorubicin, a well-established chemotherapeutic agent, is known to accumulate in the cell nucleus. By using ICP-MS, we show that the conjugation of two small organometallic rhenium complexes to this structural motif results in a significant redirection of the conjugates from the nucleus to the mitochondria. Despite this relocation, the two bioconjugates display excellent toxicity toward HeLa cells. In addition, we carried out a preliminarily investigation of aspects of cytotoxicity and present evidence that the conjugates disrupt the mitochondrial membrane potential, are strong inhibitors of human Topoisomerase II, and induce apoptosis. Such derivatives may enhance the therapeutic index of the aggressive parent drug and overcome drug resistance by influencing nuclear and mitochondrial homeostasis. PMID:26799241

  10. Lattice Dynamics of the Rhenium and Technetium Dichalcogenides.

    PubMed

    Wolverson, Daniel; Hart, Lewis S

    2016-12-01

    The rhenium and technetium dichalcogenides are layered van der Waals semiconductors which show a large number of Raman-active zone-centre phonon modes as a result of their unusually large unit cells and deviation from hexagonal symmetry. They thus offer the possibility of introducing in-plane anisotropy into composite heterostructures based on van der Waals materials, and Raman spectroscopy is generally used to determine their in-plane orientation. We show that first-principles calculations give a good description of the lattice dynamics of this family of materials and thus predict the zone-centre phonon frequencies and Raman activities of TcS2. We consider the distribution of the phonon modes in frequency and their atomic displacements and give a unified understanding of the phonon frequencies and Raman spectra of ReS2, TcS2 and ReSe2 in terms of the scaling of Raman frequency with the chalcogen mass.

  11. Molecular Epoxidation Reactions Catalyzed by Rhenium, Molybdenum, and Iron Complexes.

    PubMed

    Kück, Jens W; Reich, Robert M; Kühn, Fritz E

    2016-02-01

    Epoxidations are of high relevance in many organic syntheses, both in industry and academia. In this personal account, the development of rhenium, molybdenum, and iron complexes in molecular epoxidation catalysis is presented. Methyltrioxorhenium (MTO) is the benchmark catalyst for these reactions, with a thoroughly investigated mechanism and reactivity profile. More recently, highly active molecular molybdenum and iron catalysts have emerged, challenging the extraordinary role of MTO in epoxidation catalysis with high turnover frequencies (TOFs). This development is highlighted in its use of cheaper, more readily available metals, and the challenges of using base metals in catalysis are discussed. These results show the promise that relatively cheap and abundant metals, such as molybdenum and iron, hold for the future of epoxidation catalysis. PMID:26776087

  12. Lattice Dynamics of the Rhenium and Technetium Dichalcogenides

    NASA Astrophysics Data System (ADS)

    Wolverson, Daniel; Hart, Lewis S.

    2016-05-01

    The rhenium and technetium dichalcogenides are layered van der Waals semiconductors which show a large number of Raman-active zone-centre phonon modes as a result of their unusually large unit cells and deviation from hexagonal symmetry. They thus offer the possibility of introducing in-plane anisotropy into composite heterostructures based on van der Waals materials, and Raman spectroscopy is generally used to determine their in-plane orientation. We show that first-principles calculations give a good description of the lattice dynamics of this family of materials and thus predict the zone-centre phonon frequencies and Raman activities of TcS2. We consider the distribution of the phonon modes in frequency and their atomic displacements and give a unified understanding of the phonon frequencies and Raman spectra of ReS2, TcS2 and ReSe2 in terms of the scaling of Raman frequency with the chalcogen mass.

  13. Organometallic Rhenium Complexes Divert Doxorubicin to the Mitochondria.

    PubMed

    Imstepf, Sebastian; Pierroz, Vanessa; Rubbiani, Riccardo; Felber, Michael; Fox, Thomas; Gasser, Gilles; Alberto, Roger

    2016-02-18

    Doxorubicin, a well-established chemotherapeutic agent, is known to accumulate in the cell nucleus. By using ICP-MS, we show that the conjugation of two small organometallic rhenium complexes to this structural motif results in a significant redirection of the conjugates from the nucleus to the mitochondria. Despite this relocation, the two bioconjugates display excellent toxicity toward HeLa cells. In addition, we carried out a preliminarily investigation of aspects of cytotoxicity and present evidence that the conjugates disrupt the mitochondrial membrane potential, are strong inhibitors of human Topoisomerase II, and induce apoptosis. Such derivatives may enhance the therapeutic index of the aggressive parent drug and overcome drug resistance by influencing nuclear and mitochondrial homeostasis.

  14. Raman scattering from superhard rhenium diboride under high pressure

    SciTech Connect

    Xie, Miao; Winkler, Björn; Mao, Zhu; Kaner, Richard B.; Tolbert, Sarah H. E-mail: tolbert@chem.ucla.edu; Kavner, Abby E-mail: tolbert@chem.ucla.edu

    2014-01-06

    Lattice vibrational properties of superhard rhenium diboride (ReB{sub 2}) were examined up to 8 GPa in a diamond anvil cell using Raman spectroscopy techniques. Linear pressure coefficients and mode Grüneisen parameters are obtained. Good agreement is found between the experimental and theoretical calculated Grüneisen parameters. Examination of the calculated mode Grüneisen parameters reveals that both B-B and Re-B covalent bonds play a dominant role in supporting the applied load under pressure. A comparison of vibrations parallel and perpendicular to the c-axis indicates that bonds along the c-axis tend to take greater loads. Our results agree with observations of elastic lattice anisotropy obtained from both in situ X-ray diffraction measurements and ultrasonic resonance spectra.

  15. 27 CFR 53.185 - Credit on returns.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... evidence prescribed in the applicable regulations in this subpart and 27 CFR 70.123 (Procedure and... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Credit on returns. 53.185... Other Administrative Provisions of Special Application to Manufacturers Taxes § 53.185 Credit on...

  16. 27 CFR 53.185 - Credit on returns.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... evidence prescribed in the applicable regulations in this subpart and 27 CFR 70.123 (Procedure and... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Credit on returns. 53.185... Other Administrative Provisions of Special Application to Manufacturers Taxes § 53.185 Credit on...

  17. 46 CFR 185.506 - Passenger safety orientation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Passenger safety orientation. 185.506 Section 185.506 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS... safety orientation. If only a small number of passengers embark at a port after the original muster...

  18. 46 CFR 185.506 - Passenger safety orientation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Passenger safety orientation. 185.506 Section 185.506 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS... safety orientation. If only a small number of passengers embark at a port after the original muster...

  19. 46 CFR 185.506 - Passenger safety orientation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Passenger safety orientation. 185.506 Section 185.506 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS... safety orientation. If only a small number of passengers embark at a port after the original muster...

  20. 12 CFR 18.5 - Alternative annual disclosure statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Board (12 CFR part 225). Such schedules must be comparable to the Call Report schedules enumerated in... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Alternative annual disclosure statements. 18.5 Section 18.5 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY DISCLOSURE...

  1. 30 CFR 250.181-250.185 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false 250.181-250.185 Section 250.181-250.185 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Primary Lease Requirements, Lease...

  2. 30 CFR 250.181-250.185 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false 250.181-250.185 Section 250.181-250.185 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Primary Lease Requirements, Lease...

  3. 30 CFR 250.181-250.185 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false 250.181-250.185 Section 250.181-250.185 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Primary Lease Requirements, Lease...

  4. 49 CFR 173.185 - Lithium cells and batteries.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Lithium cells and batteries. 173.185 Section 173... Class 7 § 173.185 Lithium cells and batteries. (a) Cells and batteries. A lithium cell or battery, including a lithium polymer cell or battery and a lithium-ion cell or battery, must conform to all of...

  5. 49 CFR 173.185 - Lithium cells and batteries.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Lithium cells and batteries. 173.185 Section 173... Class 7 § 173.185 Lithium cells and batteries. (a) Cells and batteries. A lithium cell or battery, including a lithium polymer cell or battery and a lithium-ion cell or battery, must conform to all of...

  6. 49 CFR 173.185 - Lithium cells and batteries.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Lithium cells and batteries. 173.185 Section 173... Class 7 § 173.185 Lithium cells and batteries. As used in this section, lithium cell(s) or battery(ies... the lithium cells or batteries will provide electrical power for its operation. (a) Classification....

  7. 49 CFR 173.185 - Lithium cells and batteries.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Lithium cells and batteries. 173.185 Section 173... Class 7 § 173.185 Lithium cells and batteries. (a) Cells and batteries. A lithium cell or battery, including a lithium polymer cell or battery and a lithium-ion cell or battery, must conform to all of...

  8. 49 CFR 173.185 - Lithium cells and batteries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Lithium cells and batteries. 173.185 Section 173... Class 7 § 173.185 Lithium cells and batteries. (a) Cells and batteries. A lithium cell or battery, including a lithium polymer cell or battery and a lithium-ion cell or battery, must conform to all of...

  9. 27 CFR 44.185 - Label or notice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Label or notice. 44.185... Papers and Tubes by Manufacturers and Export Warehouse Proprietors Packaging Requirements § 44.185 Label... subpart, have adequately imprinted thereon, or on a label securely affixed thereto, the words...

  10. 27 CFR 44.185 - Label or notice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Label or notice. 44.185... Papers and Tubes by Manufacturers and Export Warehouse Proprietors Packaging Requirements § 44.185 Label... subpart, have adequately imprinted thereon, or on a label securely affixed thereto, the words...

  11. 27 CFR 44.185 - Label or notice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Label or notice. 44.185... Papers and Tubes by Manufacturers and Export Warehouse Proprietors Packaging Requirements § 44.185 Label... subpart, have adequately imprinted thereon, or on a label securely affixed thereto, the words...

  12. 27 CFR 44.185 - Label or notice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Label or notice. 44.185... Papers and Tubes by Manufacturers and Export Warehouse Proprietors Packaging Requirements § 44.185 Label... subpart, have adequately imprinted thereon, or on a label securely affixed thereto, the words...

  13. 27 CFR 44.185 - Label or notice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Label or notice. 44.185 Section 44.185 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES, WITHOUT PAYMENT OF TAX, OR WITH DRAWBACK...

  14. 21 CFR 137.185 - Enriched self-rising flour.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Enriched self-rising flour. 137.185 Section 137... Cereal Flours and Related Products § 137.185 Enriched self-rising flour. Enriched self-rising flour conforms to the definition and standard of identity, and is subject to the requirements for label...

  15. 21 CFR 137.185 - Enriched self-rising flour.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Enriched self-rising flour. 137.185 Section 137... Cereal Flours and Related Products § 137.185 Enriched self-rising flour. Enriched self-rising flour conforms to the definition and standard of identity, and is subject to the requirements for label...

  16. 21 CFR 137.185 - Enriched self-rising flour.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Enriched self-rising flour. 137.185 Section 137... Cereal Flours and Related Products § 137.185 Enriched self-rising flour. Enriched self-rising flour conforms to the definition and standard of identity, and is subject to the requirements for label...

  17. 21 CFR 137.185 - Enriched self-rising flour.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Enriched self-rising flour. 137.185 Section 137... Cereal Flours and Related Products § 137.185 Enriched self-rising flour. Enriched self-rising flour conforms to the definition and standard of identity, and is subject to the requirements for label...

  18. 21 CFR 137.185 - Enriched self-rising flour.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Enriched self-rising flour. 137.185 Section 137... Cereal Flours and Related Products § 137.185 Enriched self-rising flour. Enriched self-rising flour conforms to the definition and standard of identity, and is subject to the requirements for label...

  19. 5 CFR 185.139 - Appeal to authority head.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Appeal to authority head. 185.139 Section... FRAUD CIVIL REMEDIES § 185.139 Appeal to authority head. (a) Any defendant who has filed a timely answer... such decision to the authority head by filing a notice of appeal with the authority head in...

  20. 5 CFR 185.139 - Appeal to authority head.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Appeal to authority head. 185.139 Section... FRAUD CIVIL REMEDIES § 185.139 Appeal to authority head. (a) Any defendant who has filed a timely answer... such decision to the authority head by filing a notice of appeal with the authority head in...

  1. 5 CFR 185.139 - Appeal to authority head.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Appeal to authority head. 185.139 Section... FRAUD CIVIL REMEDIES § 185.139 Appeal to authority head. (a) Any defendant who has filed a timely answer... such decision to the authority head by filing a notice of appeal with the authority head in...

  2. 5 CFR 185.139 - Appeal to authority head.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Appeal to authority head. 185.139 Section... FRAUD CIVIL REMEDIES § 185.139 Appeal to authority head. (a) Any defendant who has filed a timely answer... such decision to the authority head by filing a notice of appeal with the authority head in...

  3. 5 CFR 185.139 - Appeal to authority head.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Appeal to authority head. 185.139 Section... FRAUD CIVIL REMEDIES § 185.139 Appeal to authority head. (a) Any defendant who has filed a timely answer... such decision to the authority head by filing a notice of appeal with the authority head in...

  4. 5 CFR 550.185 - Payment of availability pay.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 550.185 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.185 Payment of availability pay. (a... earnings limitation on premium pay for law enforcement officers in 5 U.S.C. 5547(c). (b) Except as...

  5. 5 CFR 550.185 - Payment of availability pay.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 550.185 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.185 Payment of availability pay. (a... earnings limitation on premium pay for law enforcement officers in 5 U.S.C. 5547(c). (b) Except as...

  6. 36 CFR 223.185 - Scope and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Scope and applicability. 223.185 Section 223.185 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER The Forest Resources Conservation and Shortage...

  7. 46 CFR 185.352 - Ventilation of gasoline machinery spaces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Ventilation of gasoline machinery spaces. 185.352... (UNDER 100 GROSS TONS) OPERATIONS Miscellaneous Operating Requirements § 185.352 Ventilation of gasoline machinery spaces. The mechanical exhaust for the ventilation of a gasoline machinery space, required...

  8. 40 CFR 160.185 - Reporting of study results.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Reporting of study results. 160.185... GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 160.185 Reporting of study results. (a) A final report shall be prepared for each study and shall include, but not necessarily be limited to,...

  9. Synthesis, characterization, and biological studies of emissive rhenium-glutamine conjugates.

    PubMed

    Huang, Rachel; Langille, Graeme; Gill, Ravanjir K; Li, Cindy Mei Jin; Mikata, Yuji; Wong, May Q; Yapp, Donald T; Storr, Tim

    2013-10-01

    Two new rhenium complexes containing pyridine-triazole (pyta) and quinoline-triazole (quinta) ligands with attached glutamine-targeting agents have been characterized and tested for uptake in the HT-29 human colon adenocarcinoma cell line. The glutamine moiety in Re(CO)3Br(pyta) (1) and Re(CO)3Br(quinta) (2) remains pendant in solution. Both complexes exhibit absorptions in the 300-400-nm range with metal-to-ligand charge transfer (MLCT) character, as predicted by time-dependent density functional theory calculations. Geometrical analysis by theoretical calculations provides information on the cationic complexes 1 (+) and 2 (+) resulting from aquo for halide ligand exchange under aqueous conditions. The emissive properties of both complexes were studied under aqueous conditions, and the measured quantum yields were 0.46 % for 1 (+) and 0.18 % for 2 (+). The large Stokes shifts and oxygen sensitivity of the emission suggest a (3)MLCT process for both complexes. Cell studies in the HT-29 cell line demonstrate that both complexes are nontoxic over a large concentration range (0-1.4 mM). Preliminary uptake studies show that 2 (+), but not 1 (+), displays significant concentration-dependent uptake at 3 and 24 h.

  10. p185, an Immunodominant Epitope, Is an Autoantigen Mimotope*

    PubMed Central

    Kumar, Sanjeev; Hinks, John A.; Maman, Joseph; Ravirajan, Chelliah T.; Pearl, Laurence H.; Isenberg, David A.

    2011-01-01

    An immunodominant peptide (p185(378–394)) derived from the c-erbB2 gene product, was recognized by an anti-DNA antibody, B3, and importantly by two classical DNA-binding proteins, Tgo polymerase and Pa-UDG. These reactivities were inhibited by DNA, confirming that the peptide mimicked DNA. BALB/c mice immunized with p185(378–394) developed significant titers of IgG anti-dsDNA antibodies. Screening of 39 human lupus sera revealed that 5% of these sera possessed reactivity toward p185(378–394). Representative mouse and human sera with anti-p185(378–394) reactivity bound intact p185, and this binding was inhibited by dsDNA. This is the first demonstration of a naturally occurring autoantigen mimotope. The present study identifies a potential antigenic stimulus that might trigger systemic lupus erythematosus in a subset of patients. PMID:21566138

  11. p185, an immunodominant epitope, is an autoantigen mimotope.

    PubMed

    Kumar, Sanjeev; Hinks, John A; Maman, Joseph; Ravirajan, Chelliah T; Pearl, Laurence H; Isenberg, David A

    2011-07-22

    An immunodominant peptide (p185(378-394)) derived from the c-erbB2 gene product, was recognized by an anti-DNA antibody, B3, and importantly by two classical DNA-binding proteins, Tgo polymerase and Pa-UDG. These reactivities were inhibited by DNA, confirming that the peptide mimicked DNA. BALB/c mice immunized with p185(378-394) developed significant titers of IgG anti-dsDNA antibodies. Screening of 39 human lupus sera revealed that 5% of these sera possessed reactivity toward p185(378-394). Representative mouse and human sera with anti-p185(378-394) reactivity bound intact p185, and this binding was inhibited by dsDNA. This is the first demonstration of a naturally occurring autoantigen mimotope. The present study identifies a potential antigenic stimulus that might trigger systemic lupus erythematosus in a subset of patients. PMID:21566138

  12. Tricarbonyl-rhenium complexes of a thiol-functionalized amphoteric poly(amidoamine).

    PubMed

    Donghi, Daniela; Maggioni, Daniela; D'Alfonso, Giuseppe; Amigoni, Federica; Ranucci, Elisabetta; Ferruti, Paolo; Manfredi, Amedea; Fenili, Fabio; Bisazza, Agnese; Cavalli, Roberta

    2009-12-14

    An amphoteric thiol-functionalized poly(amidoamine) nicknamed ISA23SH(10%) was synthesized. Rhenium complexes 1 and 2, containing 0.5 and 0.8 equiv of rhenium, respectively, were easily obtained by reacting ISA23SH(10%) with [Re(CO)(3)(H(2)O)(3)](CF(3)SO(3)) in aqueous solution at pH 5.5. Both ISA23SH(10%), and its rhenium complexes were soluble in water under physiological conditions. The resultant solutions were stable, even in the presence of cysteine. Rhenium chelation occurred through the S and N atoms of the cysteamine moiety, as demonstrated by (1)H, (13)C, and (15)N NMR spectroscopy. The diffusion coefficients and the hydrodynamic radii of ISA23SH(10%) and complex 1 were determined by pulsed gradient spin echo (PGSE) NMR experiments. The radius of the rhenium complexes 1 and 2 was always slightly larger than that of the parent polymer. TEM analysis showed that both complexes form spherical nanoparticles with narrow size distributions. Consistent results were obtained by dynamic light scattering. The observed sizes were in good agreement with those evaluated by PGSE. Preliminary in vitro and in vivo biological studies have been performed on complexes 1 and 2 as well as on the parent ISA23SH(10%). Neither hemolytic activity of the two rhenium complexes and the parent polymer, up to a concentration of 5 mg/mL, nor cytotoxic effects were observed on Hela cell after 48 h at a concentration of 100 ng/mL. In vivo toxicological tests showed that ISA23SH(10%) is highly biocompatible, with a maximum tolerated dose (MTD) of 500 mg/kg. No toxic side effects were apparent after the intravenous injection in mice of the two rhenium complexes in doses up to 20 mg/kg.

  13. Rhenium-catalysed dehydrogenative borylation of primary and secondary C(sp3)-H bonds adjacent to a nitrogen atom.

    PubMed

    Murai, Masahito; Omura, Tetsuya; Kuninobu, Yoichiro; Takai, Kazuhiko

    2015-03-18

    Rhenium-catalysed C(sp(3))-H bond borylation in the absence of any oxidant, hydrogen acceptor, or external ligand, with the generation of H2 as the sole byproduct is described. The transformation, which represents a rare example of rhenium-catalysed C(sp(3))-H bond functionalisation, features high atom efficiency and simple reaction conditions. PMID:25688385

  14. Isotopic determinations of rhenium and osmium in meteorites by using fusion, distillation and ion-exchange separations

    USGS Publications Warehouse

    Morgan, J.W.; Walker, R.J.

    1989-01-01

    A stable isotope-dilution method using resonance ionization mass spectrometry is suitable for the determination of rhenium and osmium abundances and osmium isotopic composition in carbonaceous chondrites and iron meteorites. The chemical procedure involves sodium peroxide fusion, followed by distillation of osmium from sulfuric acid/hydrogen peroxide and subsequent anion-exchange separation of rhenium from the same solution. ?? 1989.

  15. Rhenium-catalysed dehydrogenative borylation of primary and secondary C(sp3)-H bonds adjacent to a nitrogen atom.

    PubMed

    Murai, Masahito; Omura, Tetsuya; Kuninobu, Yoichiro; Takai, Kazuhiko

    2015-03-18

    Rhenium-catalysed C(sp(3))-H bond borylation in the absence of any oxidant, hydrogen acceptor, or external ligand, with the generation of H2 as the sole byproduct is described. The transformation, which represents a rare example of rhenium-catalysed C(sp(3))-H bond functionalisation, features high atom efficiency and simple reaction conditions.

  16. Supported Rhenium Complexes: Almost Uniform Rhenium Tricarbonyls Synthesized from CH[subscript 3]Re(CO)[subscript 5] and HY Zeolite

    SciTech Connect

    Lobo-Lapidus, Rodrigo J.; Gates, Bruce C.

    2010-12-07

    Supported rhenium complexes were prepared from CH{sub 3}Re(CO){sub 5} and dealuminated HY zeolite or NaY zeolite, each with a Si/Al atomic ratio of 30. The samples were characterized with infrared (IR) and extended X-ray absorption fine structure (EXAFS) spectroscopies. EXAFS data characterizing the sample formed by the reaction of CH{sub 3}Re(CO){sub 5} with dealuminated HY zeolite show that the rhenium complexes were bonded to the zeolite frame, incorporating, on average, three carbonyl ligands per Re atom (as shown by Re-C and multiple-scattering Re-O EXAFS contributions). The IR spectra, consistent with this result, show that the supported rhenium carbonyls were bonded near aluminum sites of the zeolite, as shown by the decrease in intensity of the IR bands characterizing the acidic silanol groups resulting from the reaction of the rhenium carbonyl with the zeolite. This supported metal complex was characterized by narrow peaks in the {nu}{sub CO} region of the IR spectrum, indicating highly uniform species. In contrast, the species formed from CH{sub 3}Re(CO){sub 5} on NaY zeolite lost fewer carbonyl ligands than those formed on HY zeolite and were significantly less uniform, as indicated by the greater breadth of the {nu}{sub CO} bands in the IR spectra. The results show the importance of zeolite H{sup +} sites for the formation of uniform supported rhenium carbonyls from CH{sub 3}Re(CO){sub 5}; the formation of such uniform complexes did not occur on the NaY zeolite.

  17. Detecting Enriched Ejacta in the Remnant of SN 185 AD

    NASA Astrophysics Data System (ADS)

    Fesen, Robert A.

    Low dispersion IUE spectra of early-type stars lying behind young galactic supernova remnants can provide extremely valuable and unique information via line-of-sight interception of a remnant's ejecta producing strong absorptions lines. From such data, one can directly probe the elemental composition of the remnant's cool ejecta and, in turn, obtain some clue as to the type of supernova involved and explosive nucleosynthesis. Although realized for sometime as a potentially powerful technique due to the great sensitivity of heavy element resonance UV lines for detecting even very low column densities, in practice this method has been attempted only once due to problems in identifying early-type background target stars as well as reddening limitations. The one previous study using this technique has yielded exciting and very important new data on the remnant of SN 1006 AD. Analysis of IUE data for a faint sdOB star situated behind this young supernova remnant show the presence of very strong and definitely non-stellar absorption lines in this star's UV spectrum due to several individual knots of ejecta along the line-of-sight. These features are identified as redshifted S II (1259, 1254), O I (1302), and Si IV (1393, 1402) respectively at radial velocities of 5000 to 6700 krn s^-1 (Fesen, Wu, Leventhal, and Hamilton 1986). Also, very broad and strong absorption Fe II lines at 2370 and 2600 A indicate an Fe II mass of about 0.1 solar mass. This IUE detection is presently the only direct observation of the expected large mass of iron in SN 1006. Obviously, one would very much like to apply this now proven method to investigate other young galactic supernova remnants. Recent SNR studies indicate there is one (but presently only one) young SNR for which similar observations are possible, namely SN 185 (= RCW 86). Estimates for the remnant's distance have recently decreased from 2.5 kpc to < 1.5 kpc and this together with new, more accurate radio maps make UV observations

  18. Submersion criticality safety of tungsten-rhenium urania cermet fuel for space propulsion and power applications

    SciTech Connect

    A.E. Craft; R. C. O'Brien; S. D. Howe; J. C. King

    2014-07-01

    Nuclear thermal rockets are the preferred propulsion technology for a manned mission to Mars, and tungsten–uranium oxide cermet fuels could provide significant performance and cost advantages for nuclear thermal rockets. A nuclear reactor intended for use in space must remain subcritical before and during launch, and must remain subcritical in launch abort scenarios where the reactor falls back to Earth and becomes submerged in terrestrial materials (including seawater, wet sand, or dry sand). Submersion increases reflection of neutrons and also thermalizes the neutron spectrum, which typically increases the reactivity of the core. This effect is typically very significant for compact, fast-spectrum reactors. This paper provides a submersion criticality safety analysis for a representative tungsten/uranium oxide fueled reactor with a range of fuel compositions. Each submersion case considers both the rhenium content in the matrix alloy and the uranium oxide volume fraction in the cermet. The inclusion of rhenium significantly improves the submersion criticality safety of the reactor. While increased uranium oxide content increases the reactivity of the core, it does not significantly affect the submersion behavior of the reactor. There is no significant difference in submersion behavior between reactors with rhenium distributed within the cermet matrix and reactors with a rhenium clad in the coolant channels. The combination of the flooding of the coolant channels in submersion scenarios and the presence of a significant amount of spectral shift absorbers (i.e. high rhenium concentration) further decreases reactivity for short reactor cores compared to longer cores.

  19. Rhenium(I) Tricarbonyl Complexes of meso-Tetraaryl-21,23-diheteroporphyrins.

    PubMed

    Kaur, Tejinder; Lee, Way-Zen; Ravikanth, Mangalampalli

    2016-06-01

    The dithia/diselena meso-tetraarylporphyrins have a lesser tendency to form metal complexes because of the larger size of the heteroatom(s), which shrinks the cavity size, and the heteroatoms also have poor coordinating ability to bind metal ions. The first example of a rhenium(I) tricarbonyl complex of 21,23-diselenaporphyrin was synthesized by treating 5,10,15,20-tetra-p-tolyl-21,23-diselenaporphyrin with Re(CO)5Cl in chlorobenzene at reflux temperature and its structural properties were compared with our earlier reported rhenium(I) complex of tetraaryl-21,23-dithiaporphyrin. The crystal structures of rhenium(I) complexes of diheteroporphyrins revealed that the Re(I) ion binds to both the Se/S atoms and one of the N atoms of the porphyrin core along with three terminal carbonyl groups in an octahedral fashion. The rhenium(I) complexes of 21,23-diheteroporphyrins are stabilized by a large counterion, the trichloro-bridged dirhenium(I) ion. We also present a detailed account of the spectral and redox properties of rhenium(I) tricarbonyl complexes of 21,23-diheteroporphyrins. PMID:27214498

  20. Rhenium(I) Tricarbonyl Complexes of meso-Tetraaryl-21,23-diheteroporphyrins.

    PubMed

    Kaur, Tejinder; Lee, Way-Zen; Ravikanth, Mangalampalli

    2016-06-01

    The dithia/diselena meso-tetraarylporphyrins have a lesser tendency to form metal complexes because of the larger size of the heteroatom(s), which shrinks the cavity size, and the heteroatoms also have poor coordinating ability to bind metal ions. The first example of a rhenium(I) tricarbonyl complex of 21,23-diselenaporphyrin was synthesized by treating 5,10,15,20-tetra-p-tolyl-21,23-diselenaporphyrin with Re(CO)5Cl in chlorobenzene at reflux temperature and its structural properties were compared with our earlier reported rhenium(I) complex of tetraaryl-21,23-dithiaporphyrin. The crystal structures of rhenium(I) complexes of diheteroporphyrins revealed that the Re(I) ion binds to both the Se/S atoms and one of the N atoms of the porphyrin core along with three terminal carbonyl groups in an octahedral fashion. The rhenium(I) complexes of 21,23-diheteroporphyrins are stabilized by a large counterion, the trichloro-bridged dirhenium(I) ion. We also present a detailed account of the spectral and redox properties of rhenium(I) tricarbonyl complexes of 21,23-diheteroporphyrins.

  1. [Influence of antitumor system rhenium-platinum on biochemical state of the liver].

    PubMed

    Ivchuk, V V; Polishko, T M; Golichenko, O A; Shtemenko, O V; Shtemenko, N I

    2011-01-01

    Influence of the antitumour rhenium-platinum system on biochemical liver characteristics in the model of tumor growth (Guerin carcinoma) was studied and possible hepatoprotective activity of rhenium cluster compounds when introducing them in different forms was shown, that was confirmed by decreasing of diagnostic enzymes activity in blood (aminotransferase--AST 6 times and ALT 5.6 times, lactatedehydrogenase 4.9 times, gamma-glutamyltranspeptidase 3.6 times) and normalization of morphological state of the liver cells. The hepatoprotective activity of the cluster rhenium compound with adamanthyl ligands was confirmed in the model of acute toxic hepatitis. Introduction of this compound led to reduction of the concentration of MDA in homogenates of liver tissue (2 times), and in blood plasma (3.8 times); to reduction of levels of diagnostic liver enzymes in blood--AST and ALT 5.8 and 5.5 times respectively in comparison with control group. Some aspects of the mechanism of hepatoprotection were discussed, that included the presence of conjugated systems around the quadrupol rhenium-rhenium bond and alkyl radicals with significant positive inductive effects.

  2. Dynamics of rhenium photocatalysts revealed through ultrafast multidimensional spectroscopy.

    PubMed

    Kiefer, Laura M; King, John T; Kubarych, Kevin J

    2015-04-21

    Rhenium catalysts have shown promise to promote carbon neutrality by reducing a prominent greenhouse gas, CO2, to CO and other starting materials. Much research has focused on identifying intermediates in the photocatalysis mechanism as well as time scales of relevant ultrafast processes. Recent studies have implemented multidimensional spectroscopies to characterize the catalyst's ultrafast dynamics as it undergoes the many steps of its photocycle. Two-dimensional infrared (2D-IR) spectroscopy is a powerful method to obtain molecular structure information while extracting time scales of dynamical processes with ultrafast resolution. Many observables result from 2D-IR experiments including vibrational lifetimes, intramolecular redistribution time scales, and, unique to 2D-IR, spectral diffusion, which is highly sensitive to solute-solvent interactions and motional dynamics. Spectral diffusion, a measure of how long a vibrational mode takes to sample its frequency space due to multiple solvent configurations, has various contributing factors. Properties of the solvent, the solute's structural flexibility, and electronic properties, as well as interactions between the solvent and solute, complicate identifying the origin of the spectral diffusion. With carefully chosen experiments, however, the source of the spectral diffusion can be unveiled. Within the context of a considerable body of previous work, here we discuss the spectral diffusion of several rhenium catalysts at multiple stages in the catalysis. These studies were performed in multiple polar liquids to aid in discovering the contributions of the solvent. We also performed electronic ground state 2D-IR and electronic excited state transient-2D-IR experiments to observe how spectral diffusion changes upon electronic excitation. Our results indicate that with the original Lehn catalyst in THF, relative to the ground state, the spectral diffusion slows by a factor of 3 in the equilibrated triplet metal

  3. Investigation of 186Re via radiative thermal-neutron capture on 185Re

    NASA Astrophysics Data System (ADS)

    Matters, D. A.; Lerch, A. G.; Hurst, A. M.; Szentmiklósi, L.; Carroll, J. J.; Detwiler, B.; Révay, Zs.; McClory, J. W.; McHale, S. R.; Firestone, R. B.; Sleaford, B. W.; Krtička, M.; Belgya, T.

    2016-05-01

    Partial γ -ray production cross sections and the total radiative thermal-neutron capture cross section for the 185Re(n ,γ ) 186Re reaction were measured using the Prompt Gamma Activation Analysis facility at the Budapest Research Reactor with an enriched 185Re target. The 186Re cross sections were standardized using well-known 35Cl(n ,γ )36Cl cross sections from irradiation of a stoichiometric natReCl3 target. The resulting cross sections for transitions feeding the 186Re ground state from low-lying levels below a cutoff energy of Ec=746 keV were combined with a modeled probability of ground-state feeding from levels above Ec to arrive at a total cross section of σ0=111 (6 ) b for radiative thermal-neutron capture on 185Re. A comparison of modeled discrete-level populations with measured transition intensities led to proposed revisions for seven tentative spin-parity assignments in the adopted level scheme for 186Re. Additionally, 102 primary γ rays were measured, including 50 previously unknown. A neutron-separation energy of Sn=6179.59 (5 ) keV was determined from a global least-squares fit of the measured γ -ray energies to the known 186Re decay scheme. The total capture cross section and separation energy results are comparable to earlier measurements of these values.

  4. Atomic Mass and Nuclear Binding Energy for I-185 (Iodine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume A `Nuclei with Z = 1 - 54' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms'. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope I-185 (Iodine, atomic number Z = 53, mass number A = 185).

  5. Effect of rhenium irradiations on the mechanical properties of tungsten for nuclear fusion applications

    NASA Astrophysics Data System (ADS)

    Khan, Aneeqa; Elliman, Robert; Corr, Cormac; Lim, Joven J. H.; Forrest, Andrew; Mummery, Paul; Evans, Llion M.

    2016-08-01

    As-received and annealed tungsten samples were irradiated at a temperature of 400 °C with Re and W ions to peak concentrations of 1600 appm (atomic parts per million) and damage levels of 40 dpa (displacements per atom). Mechanical properties were investigated using nanoindentation, and the orientation and depth dependence of irradiation damage was investigated using Electron Back Scatter Diffraction (EBSD). Following irradiation there was a 13% increase in hardness in the as received sheet and a 23% increase in the annealed material for both tungsten and rhenium irradiation. The difference between the tungsten and rhenium irradiated samples was negligible, suggesting that for the concentrations and damage levels employed, the presence of rhenium does not have a significant effect on the hardening mechanism. Energy dependent EBSD of annealed samples provided information about the depth distribution of the radiation damage in individual tungsten grains and confirmed that the radiation damage is orientation dependant.

  6. Electric quadrupole interaction of 100Rh in antimony, hafnium and rhenium

    NASA Astrophysics Data System (ADS)

    Kemp, W. J.; Abiona, A. A.; Kessler, P.; Timmers, H.

    2013-05-01

    Time differential perturbed angular correlation (TDPAC) spectroscopy in beryllium, zinc, rhodium, antimony, hafnium and rhenium was performed with the 100Pd/100Rh probe using four-detector arrays with relative detector orientations of 90° and 180°. The probe was synthesized using the 92Zr(12C,4n)100Pd fusion evaporation reaction, with evaporation residues recoiling into specimens of the metals. The quadrupole coupling constant for 100Rh has been determined for the first time for antimony, hafnium and rhenium, while results for the other elements agree with known values. The coupling constants for the measured hexagonal lattices of the period VI transition metals, hafnium and rhenium, show the same trend with increasing atomic number as those of period V.

  7. Methods for the separation of rhenium, osmium and molybdenum applicable to isotope geochemistry

    USGS Publications Warehouse

    Morgan, J.W.; Golightly, D.W.; Dorrzapf, A.F.

    1991-01-01

    Effective methods are described for the chemical separation of rhenium, osmium and molybdenum. The methods are based on distillation and anion-exchange chromatography, and have been the basis for rhenium-osmium isotope studies of ore deposits and meteorites. Successful anion-exchange separation of osmium requires both recognition and careful control of the osmium species in solution; thus, distillation of osmium tetroxide from a mixture of sulfuric acid and hydrogen peroxide is preferred to anion-exchange. Distribution coefficients measured for perrhenate in sulfuric acid media are sufficiently high (Kd > 500) for rhenium to be directly loaded onto an ion-exchange column from a distillation residue and subsequently eluted with nitric acid. Polymerization of molybdenum species during elution is prevented by use of a solution that is 1M in hydrochloric acid and 1M in sodium chloride. ?? 1991.

  8. Thermocouples of tantalum and rhenium alloys for more stable vacuum-high temperature performance

    NASA Technical Reports Server (NTRS)

    Morris, J. F. (Inventor)

    1977-01-01

    Thermocouples of the present invention provide stability and performance reliability in systems involving high temperatures and vacuums by employing a bimetallic thermocouple sensor wherein each metal of the sensor is selected from a group of metals comprising tantalum and rhenium and alloys containing only those two metals. The tantalum, rhenium thermocouple sensor alloys provide bare metal thermocouple sensors having advantageous vapor pressure compatibilities and performance characteristics. The compatibility and physical characteristics of the thermocouple sensor alloys of the present invention result in improved emf, temperature properties and thermocouple hot junction performance. The thermocouples formed of the tantalum, rhenium alloys exhibit reliability and performance stability in systems involving high temperatures and vacuums and are adaptable to space propulsion and power systems and nuclear environments.

  9. Thermodynamic stability and unusual strength of ultra-incompressible rhenium nitrides

    SciTech Connect

    Zhang, R. F.; Lin, Zhijun; Mao, Ho-kwang; Zhao, Yusheng

    2011-02-11

    We report on a comprehensive study of thermodynamic and mechanical properties as well as a bond-deformation mechanism on ultra-incompressible Re{sub 2} N and Re{sub 3} N. The introduction of nitrogen into the rhenium lattice leads to thermodynamic instability in Re{sub 2} N at ambient conditions and enhanced incompressibility and strength for both rhenium nitrides. Rhenium nitrides, however, show substantially lower ideal shear strength than hard ReB{sub 2} and superhard c -BN, suggesting that they cannot be intrinsically superhard. An intriguing soft “ionic bond mediated plastic deformation” mechanism is revealed to underline the physical origin of their unusual mechanical strength. These results suggest a need to reformulate the design concept of intrinsically superhard transition-metal nitrides, borides, and carbides.

  10. Rhenium uptake and distribution in phaeophyceae macroalgae, Fucus vesiculosus

    PubMed Central

    Racionero-Gómez, B.; Sproson, A. D.; Selby, D.; Gröcke, D. R.; Redden, H.; Greenwell, H. C.

    2016-01-01

    Owing to Rhenium (Re) having no known biological role, it is not fully understood how Re is concentrated in oil kerogens. A commonly held assumption is that Re is incorporated into decomposing biomass under reducing conditions. However, living macroalgae also concentrate Re to several orders of magnitude greater than that of seawater. This study uses Fucus vesiculosus to assess Re uptake and its subsequent localization in the biomass. It is demonstrated that the Re abundance varies within the macroalgae and that Re is not located in one specific structure. In F. vesiculosus, the uptake and tolerance of Re was evaluated via tip cultures grown in seawater of different Re(VII) compound concentrations (0–7450 ng g−1). A positive correlation is shown between the concentration of Re-doped seawater and the abundance of Re accumulated in the tips. However, significant differences between Re(VII) compounds are observed. Although the specific cell structures where the Re is localized is not known, our findings suggest that Re is not held within chloroplasts or cytoplasmic proteins. In addition, metabolically inactivated F. vesiculosus does not accumulate Re, which indicates that Re uptake is via syn-life bioadsorption/bioaccumulation and that macroalgae may provide a source for Re phytomining and/or bioremediation. PMID:27293798

  11. Rhenium Dichalcogenides: Layered Semiconductors with Two Vertical Orientations.

    PubMed

    Hart, Lewis; Dale, Sara; Hoye, Sarah; Webb, James L; Wolverson, Daniel

    2016-02-10

    The rhenium and technetium diselenides and disulfides are van der Waals layered semiconductors in some respects similar to more well-known transition metal dichalcogenides (TMD) such as molybdenum sulfide. However, their symmetry is lower, consisting only of an inversion center, so that turning a layer upside-down (that is, applying a C2 rotation about an in-plane axis) is not a symmetry operation, but reverses the sign of the angle between the two nonequivalent in-plane crystallographic axes. A given layer thus can be placed on a substrate in two symmetrically nonequivalent (but energetically similar) ways. This has consequences for the exploitation of the anisotropic properties of these materials in TMD heterostructures and is expected to lead to a new source of domain structure in large-area layer growth. We produced few-layer ReS2 and ReSe2 samples with controlled "up" or "down" orientations by micromechanical cleavage and we show how polarized Raman microscopy can be used to distinguish these two orientations, thus establishing Raman as an essential tool for the characterization of large-area layers. PMID:26799768

  12. Rhenium-osmium isotope systematics of carbonaceous chondrites

    USGS Publications Warehouse

    Walker, R.J.; Morgan, J.W.

    1989-01-01

    Rhenium and osmium concentrations and Os isotopic compositions of eight carbonaceous chondrites, one LL3 ordinary chondrite, and two iron meteorites were determined by resonance ionization mass spectrometry. Iron meteorite 187Re/186Os and 187OS/186Os ratios plot on the previously determined iron meteorite isochron, but most chondrite data plot 1 to 2 percent above this meteorite isochron. This suggests either that irons have significantly younger Re-Os closure ages than chondrites or that chondrites were formed from precursor materials with different chemical histories from the precursors of irons. Some samples of Semarkona (LL3) and Murray (C2M) meteorites plot 4 to 6 percent above the iron meteorite isochron, well above the field delineated by other chondrites. Murray may have lost Re by aqueous leaching during its preterrestrial history. Semarkona could have experienced a similar loss of Re, but only slight aqueous alteration is evident in the meteorite. Therefore, the isotopic composition of Semarkona could reflect assembly of isotopically heterogeneous components subsequent to 4.55 billion years ago or Os isotopic heterogeneities in the primordial solar nebula.

  13. Polymer Photovoltaic Cells with Rhenium Oxide as Anode Interlayer.

    PubMed

    Wei, Jinyu; Bai, Dongdong; Yang, Liying

    2015-01-01

    The effect of a new transition metal oxide, rhenium oxide (ReO3), on the performance of polymer solar cells based on regioregular poly(3-hexylthiophene) (P3HT) and methanofullerene [6,6]-phenyl C61-butyric acid methyl ester (PCBM) blend as buffer layer was investigated. The effect of the thickness of ReO3 layer on electrical characteristics of the polymer solar cells was studied. It is found that insertion of ReO3 interfacial layer results in the decreased performance for P3HT: PCBM based solar cells. In order to further explore the mechanism of the decreasing of the open-circuit voltage (Voc), the X-ray photoelectron spectroscopy (XPS) is used to investigate the ReO3 oxidation states. Kelvin Probe method showed that the work function of the ReO3 is estimated to be 5.13eV after thermal evaporation. The results indicated the fact that a portion of ReO3 decomposed during thermal evaporation process, resulting in the formation of a buffer layer with a lower work function. As a consequence, a higher energy barrier was generated between the ITO and the active layer. PMID:26226439

  14. Polymer Photovoltaic Cells with Rhenium Oxide as Anode Interlayer.

    PubMed

    Wei, Jinyu; Bai, Dongdong; Yang, Liying

    2015-01-01

    The effect of a new transition metal oxide, rhenium oxide (ReO3), on the performance of polymer solar cells based on regioregular poly(3-hexylthiophene) (P3HT) and methanofullerene [6,6]-phenyl C61-butyric acid methyl ester (PCBM) blend as buffer layer was investigated. The effect of the thickness of ReO3 layer on electrical characteristics of the polymer solar cells was studied. It is found that insertion of ReO3 interfacial layer results in the decreased performance for P3HT: PCBM based solar cells. In order to further explore the mechanism of the decreasing of the open-circuit voltage (Voc), the X-ray photoelectron spectroscopy (XPS) is used to investigate the ReO3 oxidation states. Kelvin Probe method showed that the work function of the ReO3 is estimated to be 5.13eV after thermal evaporation. The results indicated the fact that a portion of ReO3 decomposed during thermal evaporation process, resulting in the formation of a buffer layer with a lower work function. As a consequence, a higher energy barrier was generated between the ITO and the active layer.

  15. Graphite-Conjugated Rhenium Catalysts for Carbon Dioxide Reduction.

    PubMed

    Oh, Seokjoon; Gallagher, James R; Miller, Jeffrey T; Surendranath, Yogesh

    2016-02-17

    Condensation of fac-Re(5,6-diamino-1,10-phenanthroline)(CO)3Cl to o-quinone edge defects on graphitic carbon surfaces generates graphite-conjugated rhenium (GCC-Re) catalysts that are highly active for CO2 reduction to CO in acetonitrile electrolyte. X-ray photoelectron and X-ray absorption spectroscopies establish the formation of surface-bound Re centers with well-defined coordination environments. GCC-Re species on glassy carbon surfaces display catalytic currents greater than 50 mA cm(-2) with 96 ± 3% Faradaic efficiency for CO production. Normalized for the number of Re active sites, GCC-Re catalysts exhibit higher turnover frequencies than that of a soluble molecular analogue, fac-Re(1,10-phenanthroline)(CO)3Cl, and turnover numbers greater than 12,000. In contrast to the molecular analogue, GCC-Re surfaces display a Tafel slope of 150 mV/decade, indicative of a catalytic mechanism involving rate-limiting one-electron transfer. This work establishes graphite-conjugation as a powerful strategy for generating well-defined, tunable, heterogeneous electrocatalysts on ubiquitous graphitic carbon surfaces. PMID:26804469

  16. Rhenium uptake and distribution in phaeophyceae macroalgae, Fucus vesiculosus.

    PubMed

    Racionero-Gómez, B; Sproson, A D; Selby, D; Gröcke, D R; Redden, H; Greenwell, H C

    2016-05-01

    Owing to Rhenium (Re) having no known biological role, it is not fully understood how Re is concentrated in oil kerogens. A commonly held assumption is that Re is incorporated into decomposing biomass under reducing conditions. However, living macroalgae also concentrate Re to several orders of magnitude greater than that of seawater. This study uses Fucus vesiculosus to assess Re uptake and its subsequent localization in the biomass. It is demonstrated that the Re abundance varies within the macroalgae and that Re is not located in one specific structure. In F. vesiculosus, the uptake and tolerance of Re was evaluated via tip cultures grown in seawater of different Re(VII) compound concentrations (0-7450 ng g(-1)). A positive correlation is shown between the concentration of Re-doped seawater and the abundance of Re accumulated in the tips. However, significant differences between Re(VII) compounds are observed. Although the specific cell structures where the Re is localized is not known, our findings suggest that Re is not held within chloroplasts or cytoplasmic proteins. In addition, metabolically inactivated F. vesiculosus does not accumulate Re, which indicates that Re uptake is via syn-life bioadsorption/bioaccumulation and that macroalgae may provide a source for Re phytomining and/or bioremediation. PMID:27293798

  17. Human TTR conformation altered by rhenium tris-carbonyl derivatives.

    PubMed

    Ciccone, Lidia; Policar, Clotilde; Stura, Enrico A; Shepard, William

    2016-09-01

    Transthyretin (TTR) is a 54 kDa homotetrameric serum protein that transports thyroxine (T4) and retinol. TTR is potentially amyloidogenic due to homotetramer dissociation into monomeric intermediates that self-assemble as amyloid deposits and insoluble fibrils. Most crystallographic structures, including those of amyloidogenic variants show the same tetramer without major variations in the monomer-monomer interface nor in the volume of the interdimeric cavity. Soaking TTR crystals in a solution containing rhenium tris-carbonyl derivatives yields a TTR conformer never observed before. Only one of the two monomers of the crystallographic dimer is significantly altered, and the inner part of the T4 binding cavity is expanded at one end and shrunk at the other. The result redefines the mechanism of allosteric communication between the two sites, suggesting that negative cooperativity is a function of dimer asymmetry, which can be induced through internal or external binding. An aspect that remains unexplained is why the conformational changes are ubiquitous throughout the crystal although the heavy metal content of the derivatized crystals is relatively low. The conformational changes observed, which include Leu(82), may represent a form of TTR better at scavenging β-Amyloid. At a resolution of 1.69Å, with excellent refinement statistics and well defined electron density for all parts of the structure, it is possible to envisage answering important questions that range from protein cooperative behavior to heavy atom induced protein conformational modifications that can result in crystallographic non-isomorphism. PMID:27402536

  18. High-Temperature Oxidation Behavior of Iridium-Rhenium Alloys

    NASA Technical Reports Server (NTRS)

    Reed, Brian D.

    1995-01-01

    The life-limiting mechanism for radiation-cooled rockets made from iridium-coated rhenium (Ir/Re) is the diffusion of Re into the Ir layer and the subsequent oxidation of the resulting Ir-Re alloy from the inner surface. In a previous study, a life model for Ir/Re rockets was developed. It incorporated Ir-Re diffusion and oxidation data to predict chamber lifetimes as a function of temperature and oxygen partial pressure. Oxidation testing at 1540 deg C suggested that a 20-wt percent Re concentration at the inner wall surface should be established as the failure criterion. The present study was performed to better define Ir-oxidation behavior as a function of Re concentration and to supplement the data base for the life model. Samples ranging from pure Ir to Ir-40 wt percent Re (Ir-40Re) were tested at 1500 deg C, in two different oxygen environments. There were indications that the oxidation rate of the Ir-Re alloy increased significantly when it went from a single-phase solid solution to a two-phase mixture, as was suggested in previous work. However, because of testing anomalies in this study, there were not enough dependable oxidation data to definitively raise the Ir/Re rocket failure criterion from 20-wt percent Re to a Re concentration corresponding to entry into the two-phase region.

  19. Formation and stability of point defects in monolayer rhenium disulfide

    NASA Astrophysics Data System (ADS)

    Horzum, S.; ćakır, D.; Suh, J.; Tongay, S.; Huang, Y.-S.; Ho, C.-H.; Wu, J.; Sahin, H.; Peeters, F. M.

    2014-04-01

    Recently, rhenium disulfide (ReS2) monolayers were experimentally extracted by conventional mechanical exfoliation technique from as-grown ReS2 crystals. Unlike the well-known members of transition metal dichalcogenides (TMDs), ReS2 crystallizes in a stable distorted-1T structure and lacks an indirect to direct gap crossover. Here we present an experimental and theoretical study of the formation, energetics, and stability of the most prominent lattice defects in monolayer ReS2. Experimentally, irradiation with 3-MeV He+2 ions was used to break the strong covalent bonds in ReS2 flakes. Photoluminescence measurements showed that the luminescence from monolayers is mostly unchanged after highly energetic α particle irradiation. In order to understand the energetics of possible vacancies in ReS2 we performed systematic first-principles calculations. Our calculations revealed that the formation of a single sulfur vacancy has the lowest formation energy in both Re and S rich conditions and a random distribution of such defects are energetically more preferable. Sulfur point defects do not result in any spin polarization whereas the creation of Re-containing point defects induce magnetization with a net magnetic moment of 1-3μB. Experimentally observed easy formation of sulfur vacancies is in good agreement with first-principles calculations.

  20. 40 CFR 18.5 - Qualifications for Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection Research Fellowships. 18.5 Section 18.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.5 Qualifications for Environmental Protection Research Fellowships. Scholastic and...

  1. 40 CFR 18.5 - Qualifications for Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Protection Research Fellowships. 18.5 Section 18.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.5 Qualifications for Environmental Protection Research Fellowships. Scholastic and...

  2. 40 CFR 18.5 - Qualifications for Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Protection Research Fellowships. 18.5 Section 18.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.5 Qualifications for Environmental Protection Research Fellowships. Scholastic and...

  3. 40 CFR 18.5 - Qualifications for Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Protection Research Fellowships. 18.5 Section 18.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.5 Qualifications for Environmental Protection Research Fellowships. Scholastic and...

  4. 40 CFR 18.5 - Qualifications for Environmental Protection Research Fellowships.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection Research Fellowships. 18.5 Section 18.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.5 Qualifications for Environmental Protection Research Fellowships. Scholastic and...

  5. NLC Positron Target Heating(LCC-0065)

    SciTech Connect

    Schultz, D

    2003-10-07

    The NLC requires an intense beam with a large number of positrons. These positrons are produced by a high energy electron beam impinging on a solid tungsten-rhenium alloy target. The particle shower that develops in the solid target deposits significant energy in the material, leading to target stresses and potentially to target damage. The stresses can be analyzed once the magnitude and extent of the energy deposition is known. This note details the modeling of the energy deposition using EGS, performed for the NLC and the SLC targets and for possible NLC targets made of copper or nickel instead of WRe.

  6. Synthesis and spectroscopic characterization of super-stable rhenium(V)porphyrins

    NASA Astrophysics Data System (ADS)

    Bichan, N. G.; Tyulyaeva, E. Yu.; Khodov, I. A.; Lomova, T. N.

    2014-03-01

    The preparation of rhenium(V) porphyrin complexes {μ-oxo-bis[(oxo)(5,10,15,20-tetraphenyl-21H,23H-porphinato)rhenium(V)] [OReTPP]2O (1), (oxo)(phenoxo)(2,3,7,8,12,13,17,18-octaethyl-5-monophenyl-21H,23H-porphinato)rhenium(V) ORe(PhO)MPOEP (2), (cloro)(oxo)(2,3,7,8,12,13,17,18-octaethyl-5,15-diphenyl-21H,23H-porphinato)rhenium(V) ORe(Cl)5,15DPOEP (4), and (oxo)(phenoxo)(2,3,7,8,12,13,17,18-octaethyl-21H,23H-porphinato)rhenium(V) ORe(PhO)OEP (5)} by the interaction of H2ReCl6 with corresponding porphyrin in boiling phenol is described. (Cloro)(oxo)(2,3,7,8,12,13,17,18-octaethyl-5-monophenyl-21H,23H-porphinato)rhenium(V) ORe(Cl)MPOEP (3) and (oxo)(chloro)(2,3,7,8,12,13,17,18-octaethyl-21H,23H-porphinato)rhenium(V) ORe(Cl)OEP (6) have been prepared by the reaction of axial-ligand substitution from (2) and (5), respectively. Compounds (2-4) were newly synthesized. Characterization of the compounds (1-6) reported herein was made mainly by UV-Visible, IR, 1Н NMR, 1H1H 2D COSY, 1H1H 2D DOSY, 1H1H 2D ROESY, 1H1H 2D TOCSY spectroscopic techniques and elemental analysis. The stability of the complexes in solutions when exposed to strong acids at the presence of atmospheric oxygen has been estimated. Compounds (2-4) and (6) show them super-stable since they do not undergo dissociation along MN bonds in concentrated H2SO4 under heating up to 363 K. Compounds (3) and (4) undergo one-electron oxidation to form stable π-cation radicals ORe(HSO)P under these conditions. The products of the reaction between all studied porphyrins and concentrated H2SO4 were isolated in CHCl3 by reprecipitation onto ice and proved to be rhenium(V) complexes ORe(HSO4)P.

  7. Synthesis, crystal structure and magnetic properties of a novel heterobimetallic rhenium(IV)-dysprosium(III) chain.

    PubMed

    Pejo, Carolina; Guedes, Guilherme P; Novak, Miguel A; Speziali, Nivaldo L; Chiozzone, Raúl; Julve, Miguel; Lloret, Francesc; Vaz, Maria G F; González, Ricardo

    2015-06-01

    The use of the mononuclear rhenium(IV) precursor [ReBr5 (H2 pydc)](-) (H2 pydc=3,5-pyridinedicarboxylic acid) as a metalloligand towards dysprosium(III) afforded the first heterobimetallic Re(IV) -Dy(III) complex. Crystal structures and static and dynamic magnetic properties of both rhenium-containing species are reported herein. The 5d-4f compound shows an extended 1D structure and the AC magnetic measurements reveal frequency dependence at low temperature suggesting slow relaxation of the magnetization.

  8. Novel rhenium gasket design for nuclear resonant inelastic x-ray scattering at high pressure

    SciTech Connect

    Tanis, Elizabeth A.; Giefers, Hubertus; Nicol, Malcolm F.

    2008-02-15

    For the first time, a highly absorbing element, rhenium, has been proven to be a strong, reliable, and safe gasket material for achieving high pressure in nuclear resonant inelastic x-ray scattering (NRIXS) experiments. Rhenium foil was cut into rectangular slices and in order to reduce absorption, the elevated imprint due to preindenting of the gasket is removed using electrical discharge machining. By utilizing this novel gasket design, transmission losses were mitigated while performing NRIXS experiments conducted on the {sup 119}Sn and {sup 57}Fe Moessbauer isotopes.

  9. Gondola-shaped tetra-rhenium metallacycles modified evanescent wave infrared chemical sensors for selective determination of volatile organic compounds.

    PubMed

    Huang, Genin Gary; Lee, Chung-Jay; Tsai, Bo-Chan; Yang, Jyisy; Sathiyendiran, Malaichamy; Lu, Kuang-Lieh

    2011-07-15

    Water-stable and cavity-contained rhenium metallacycles were synthesized, and their ability to selectively interact with volatile organic compounds (VOCs) systematically studied using attenuated total reflection infrared (ATR-IR) spectroscopy. Integrating the unique properties of rhenium metallacycles into optical sensing technologies significantly improves selectivity in detecting aromatic compounds. To explore the interaction of rhenium metallacycles with VOCs, the surface of ATR sensing elements was modified with the synthesized rhenium metallacycles and used to detect VOCs. The results indicate that rhenium metallacycles have crown ether-like recognition sites, which can selectively interact with aromatic compounds, especially those bearing polar functional groups. The IR absorption bands of rhenium metallacycles shift significantly upon adsorption of aromatic VOCs, revealing a strong interaction between the tetra-rhenium metallacycles and guest aromatic compounds. Optimizing the thickness of the metallacycles coated on the surface of the sensing element led to rapid response in detection. The dynamic range of response was generally up to 30 mg/L with detection limits ca. 30 μg/L. Further studies of the effect of interferences indicate that recovery can be higher than 95% for most of the compounds tested. The results on the flow-cell device indicated that the performances were similar to a static detection system but the detection of VOCs can be largely simplified.

  10. Rhenium tricarbonyl core complexes of thymidine and uridine derivatives.

    PubMed

    Wei, Lihui; Babich, John; Eckelman, William C; Zubieta, Jon

    2005-04-01

    Thymidine and uridine were modified at the C2' and C5' ribose positions to form amine analogues of the nucleosides (1 and 4). Direct amination with NaBH(OAc)3 in DCE with the appropriate aldehydes yielded 1-{5-[(bis(pyridin-2-ylmethyl)amino)methyl]-4-hydroxytetrahydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (L1), 1-{5-[(bis(quinolin-2-ylmethyl)amino)methyl]-4-hydroxytetrahydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (L2), and 1-[3-(bis(pyridin-2-ylmethyl)amino)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione (L5), while standard coupling procedures of 1 and 4 with 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid (2) and 5-(bis(quinolin-2-ylmethyl)amino)pentanoic acid (3) in the presence of HOBT-EDCI in DMF provided a second novel series of bifunctional chelators: 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid [(3-hydroxy-5-(5-methyl-4-oxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-yl)methyl] amide (L3), 5-(bis(quinolin-2-ylmethyl)amino)pentanoic acid [(3-hydroxy-5-(5-methyl-4-oxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-yl)methyl] amide (L4), 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid [2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl] amide (L6), and 5-(bis(quinolin-2-ylmethyl)amino)pentanoic acid [2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl] amide (L7). The rhenium tricarbonyl complexes of L1-L4, L6, and L7, [Re(CO)3(LX)]Br (X=1-4, 6, 7: compounds 5-10, respectively), have been prepared by reacting the appropriate ligand with [NEt4][Re(CO)3Br3] in methanol. The ligands and their rhenium complexes were obtained in good yields and characterized by common spectroscopic techniques including 1D and 2D NMR, HRMS, IR, cyclic voltammetry, UV, and luminescence spectroscopy and X-ray crystallography. The crystal structure of complex 6.0.5NaPF6 displays a facial geometry of the carbonyl ligands. The nitrogen donors of the tridentate ligand

  11. Experimental constraints on the mobility of Rhenium in silicate liquids

    NASA Astrophysics Data System (ADS)

    MacKenzie, Jason M.; Canil, Dante

    2006-10-01

    The volatization of Rhenium (Re) from melts of natural basalt, dacite and a synthetic composition in the CaO-MgO-Al 2O 3-SiO 2 system has been investigated at 0.1 MPa and 1250-1350 °C over a range of fO 2 conditions from log fO 2 = -10 to -0.68. Experiments were conducted using open top Pt crucibles doped with Re and Yb. Analysis of quenched glasses by laser ablation-inductively coupled plasma mass spectrometry (LA-ICP-MS) normal to the melt/gas interface showed concentration profiles for Re, to which a semi-infinite one-dimensional diffusion model could be applied to extract diffusion coefficients ( D). The results show Re diffusivity in basalt at 1300 °C in air is log DRe = -7.2 ± 0.3 cm 2/s and increases to log DRe = -6.6 ± 0.3 cm 2/s when trace amounts of Cl were added to the starting material. At fO 2 conditions below the nickel-nickel oxide (NNO) buffer Re diffusivity decreases to logDRereducing=-7.6±0.2cm/s and to logDRedacite=-8.4±0.2cm/s in dacitic melt. In the CMAS composition, logDReCMAS=-7.5±0.1. The diffusivity of Re is comparable to Ar and CO 2 in basalt at 500 MPa favoring its release as a volatile. Our results support the contention that subaerial degassing is the cause of lower Re concentrations in arc-type and ocean island basalts compared to mid-ocean ridge basalts.

  12. Luminescence modulations of rhenium tricarbonyl complexes induced by structural variations.

    PubMed

    Bertrand, Hélène C; Clède, Sylvain; Guillot, Régis; Lambert, François; Policar, Clotilde

    2014-06-16

    Octahedral d(6) low-spin Re(I) tricarbonyl complexes are of considerable interest as noninvasive imaging probes and have been deeply studied owing to their biological stability, low toxicity, large Stokes shifts, and long luminescence lifetimes. We reported recently the bimodal IR and luminescence imaging of a Re(I) tricarbonyl complex with a Pyta ligand (4-(2-pyridyl)-1,2,3-triazole) in cells and labeled such metal-carbonyl complexes SCoMPIs for single-core multimodal probes for imaging. Re(I) tricarbonyl complexes have unique photophysical properties allowing for their unequivocal detection in cells but also present some weaknesses such as a very low luminescence quantum yield in aqueous medium. Further optimizations would thus be desirable. We therefore developed new Re(I) tricarbonyl complexes prepared from different ancillary ligands. Complexes with benzothiadiazole-triazole ligands show interesting luminescent quantum yields in acetonitrile and may constitute valuable luminescent metal complexes in organic media. A series of complexes with bidentate 1-(2-quinolinyl)-1,2,3-triazole (Taquin) and 1-(2-pyridyl)-1,2,3-triazole (Tapy) ligands bearing various 4-substituted alkyl side chains has been designed and synthesized with efficient procedures. Their photophysical properties have been characterized in acetonitrile and in a H2O/DMSO (98/2) mixture and compared with those of the parent Quinta- and Pyta-based complexes. Tapy complexes bearing long alkyl chains show impressive enhancement of their luminescent properties relative to the parent Pyta complex. Theoretical calculations have been performed to further characterize this new class of rhenium tricarbonyl complexes. Preliminary cellular imaging studies in MDA-MB231 breast cancer cells reveal a strong increase in the luminescence signal in cells incubated with the Tapy complex substituted with a C12 alkyl chain. This study points out the interesting potential of the Tapy ligand in coordination chemistry

  13. Rhenium-188 and copper-67 radiopharmaceuticals for the treatment of bladder cancer.

    PubMed

    Frier, Malcolm

    2004-01-01

    The favourable nuclear properties of copper-67 and rhenium-188 for therapeutic application are described, together with methods for the chemical synthesis of a number of derivatives. Survival from invasive bladder cancer has changed little over the past 20 years. The intravesicular administration of Cu-67 or Re-188 radiopharmaceuticals in the treatment of bladder cancer offers some promise for improvement in this situation.

  14. [Spectrophotometric study of the interaction between rhenium complexes and phosphatidylcholine during liposome formation].

    PubMed

    Shtemenko, O V; Zeleniuk, M A; Shtemenko, N I; Verbyts'ka, Ia S

    2002-01-01

    The electron absorption spectra of halogenides and halogencarboxylate complex compounds of rhenium (III) having cluster structure with phosphatydilcholine and their lyposome forms were investigated. Some results which evidence for the interaction of these compounds with phosphatydilcholine were obtained. The possible mechanism of this interaction is discussed. PMID:12924020

  15. Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes.

    PubMed

    Bader, C A; Carter, E A; Safitri, A; Simpson, P V; Wright, P; Stagni, S; Massi, M; Lay, P A; Brooks, D A; Plush, S E

    2016-06-21

    Fourier transform infrared (FTIR) microspectroscopy and confocal imaging have been used to demonstrate that the neutral rhenium(i) tricarbonyl 1,10-phenanthroline complex bound to 4-cyanophenyltetrazolate as the ancillary ligand is able to localise in regions with high concentrations of polar lipids such as phosphatidylethanolamine (PE), sphingomyelin, sphingosphine and lysophosphatidic acid (LPA) in mammalian adipocytes. PMID:27170554

  16. Potentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis

    PubMed Central

    Li, Bin-bin; Li, Dong-liang; Chen, Chao; Liu, Bao-hai; Xia, Chun-yan; Wu, Han-jun; Wu, Chao-qun; Ji, Guo-qin; Liu, Su; Ni, Wu; Yao, Ding-kang; Zeng, Zhi-yu; Chen, Da-gui; Qin, Bao-dong; Xin, Xuan; Yan, Gang-li; Dan Tang; Liu, Hui-min; He, Jin; Yan, Hongli; Zhu, Wei-Jian; Yu, Hong-yu; Zhu, Liang

    2016-01-01

    Early diagnosis of liver fibrosis is critical for early intervention and prognosis of various chronic liver diseases. Conventional repeated histological assessment is impractical due to the associated invasiveness. In the current study, we evaluated circulating miR-185 as a potential biomarker to predict initiation and progression of liver fibrosis. We found that miR-185 was significantly up-regulated in blood specimens from patients with HBV-liver fibrosis and rats with liver fibrosis, the miR-185 levels were correlated with liver fibrosis progression, but not with the different viral loads in HBV-infected patients. miR-185 was observed in collagen deposition regions during advanced liver fibrosis. We found that differences in miR-185 levels facilitated the discrimination between early-staged or advanced-staged liver fibrosis and the healthy controls with high specificity, sensitivity, and likelihood ratio using receiver-operator characteristic analysis. miR-185 targeted SREBF1, and increased expression of COL1A1 and a-SMA genes that are hallmarks of liver fibrosis. Our data supported that circulating miR-185 levels could be used as potential biomarkers for the early diagnosis of liver fibrosis. PMID:27677421

  17. Optical observation of supernova remnant in elliptical galaxy NGC 185

    NASA Astrophysics Data System (ADS)

    Vučetić, M.; Arbutina, B.; Pavlovic, M. Z.; Ciprijanovic, A.; Urosevic, D.; Petrov, N.; Onić, D.; Trcka, A.

    2016-06-01

    In this paper we discuss the previously known optical supernova remnant (SNR) in NGC 185 galaxy, a dwarf elliptical companion of the Andromeda galaxy, in order to gain more information about its properties and evolutionary status. To this end, we observed a central portion of NGC 185, through the narrowband Hα and [SII]} filters, on a 2m RCC-telescope at National astronomical observatory Rozhen, Bulgaria. Also, we performed MHD simulations using the Pluto code, for the case of low environmental density and high pressure, in order to discuss evolution of a SNR in a gas poor dwarf galaxy.

  18. 2 x 2 Polyethylene Reflected and Moderated Highly Enriched Uranium System with Rhenium

    SciTech Connect

    A. Nichole Ellis; Jesson Hutchinson; John D. Bess; Dmitry N. Polyakov; Evgeny S. Glushkov; Alexey E. Glushkov

    2010-09-01

    The 2 × 2 array HEU-Re experiment was performed on the Planet universal critical assembly machine on November 4th, 2003 at the Los Alamos Critical Experiments Facility (LACEF) at Los Alamos National Laboratory (LANL). For this experiment, there were 10 ½ units, each full unit containing four HEU foils and two rhenium foils. The top unit contained only two HEU foils and two rhenium foils. A total of 42 HEU foils were used for this experiment. Rhenium is a desirable cladding material for space nuclear power applications. This experiment consisted of HEU foils interleaved with rhenium foils and is moderated and reflected by polyethylene plates. A unit consisted of a polyethylene plate, which has a recess for rhenium foils, and four HEU foils in a single layer in the top recess of each polyethylene plate. The Planet universal criticality assembly machine has been previously used in experiments containing HEU foils interspersed with SiO2 (HEU-MET-THERM-001), Al (HEU-MET-THERM-008), MgO (HEU-MET-THERM-009), Gd foils (HEU-MET-THERM-010), 2 × 2 × 26 Al (HEU-MET-THERM-012), Fe (HEU-MET-THERM-013 and HEU-MET-THERM-015), 2 × 2 × 23 SiO2 (HEU-MET-THERM-014), 2 × 2 × 11 hastalloy plates (HEU-MET-THERM-016), and concrete (HEU-MET-THERM-018). The 2 × 2 array of HEU-Re is considered acceptable for use as a benchmark critical experiment.

  19. Photochemical and electrochemical catalytic reduction of CO2 with NHC-containing dicarbonyl rhenium(i) bipyridine complexes.

    PubMed

    Maurin, Antoine; Ng, Chi-On; Chen, Lingjing; Lau, Tai-Chu; Robert, Marc; Ko, Chi-Chiu

    2016-10-01

    The electrochemical and photochemical catalytic reductions of CO2 using N,O and N,S-NHC-containing dicarbonyl rhenium(i) bipyridine complexes have been investigated. By replacing the carbonyl ligand in tricarbonyl rhenium(i) complexes with a weaker π-accepting ligand, the characteristic MLCT transitions shifted to lower energy. This makes photocatalysts capable of harvesting low-energy visible light for catalyzing CO2 reduction. A detailed study revealed that these dicarbonyl rhenium(i) complexes are also highly selective for photocatalysis of CO2 to CO with a good quantum efficiency (10%), similar to that of the tricarbonyl rhenium(i) complex analogues. From the electrochemical study, it was observed that the catalysts efficiently produce CO from CO2 with high turnover frequency and good stability over time.

  20. Evaluation of oxide-coated iridium-rhenium chambers

    NASA Technical Reports Server (NTRS)

    Reed, Brian D.

    1994-01-01

    Iridium-coated rhenium (Ir-Re) provides long life operation of radiation-cooled rockets at temperatures up to 2200 C. Ceramic oxide coatings could be used to increase Ir-Re rocket lifetimes and allow operation in highly oxidizing environments. Ceramic oxide coatings promise to serve as both thermal and diffusion barriers for the iridium layer. Seven ceramic oxide-coated Ir-Re, 22-N rocket chambers were tested with gaseous hydrogen/gaseous oxygen (GHz/G02) propellants. Five chambers had thick (over 10 mils), monolithic coatings of either hafnia (HfO2) or zirconia (ZrO2). Two chambers had coatings with thicknesses less than 5 mils. One of these chambers had a thin-walled coating of ZrO2 infiltrated with sol gel HfO2. The other chamber had a coating composed of an Ir-oxide composite. The purpose of this test program was to assess the ability of the oxide coatings to withstand the thermal shock of combustion initiation, adhere under repeated thermal cycling, and operate in aggressively oxidizing environments. All of the coatings survived the thermal shock of combustion and demonstrated operation at mixture ratios up to 11. Testing the Ir-oxide composite-coated chamber included over 29 min at mixture ratio 16. The thicker walled coatings provided the larger temperature drops across the oxide layer (up to 570 C), but were susceptible to macrocracking and eventual chipping at a stress concentrator. The cracks apparently resealed during firing, under compression of the oxide layer. The thinner walled coatings did not experience the macrocracking and chipping of the chambers that was seen with the thick, monolithic coatings. However, burn-throughs in the throat region did occur in both of the thin-walled chambers at mixture ratios well above stoichiometric. The burn-throughs were probably the result of oxygen diffusion through the oxide coating that allowed the underlying Ir and Re layers to be oxidized. The results of this test program indicated that the thin-walled oxide

  1. Testing of electroformed deposited iridium/powder metallurgy rhenium rockets

    NASA Technical Reports Server (NTRS)

    Reed, Brian D.; Dickerson, Robert

    1996-01-01

    High-temperature, oxidation-resistant chamber materials offer the thermal margin for high performance and extended lifetimes for radiation-cooled rockets. Rhenium (Re) coated with iridium (Ir) allow hours of operation at 2200 C on Earth-storable propellants. One process for manufacturing Ir/Re rocket chambers is the fabrication of Re substrates by powder metallurgy (PM) and the application of Ir coatings by using electroformed deposition (ED). ED Ir coatings, however, have been found to be porous and poorly adherent. The integrity of ED Ir coatings could be improved by densification after the electroforming process. This report summarizes the testing of two 22-N, ED Ir/PM Re rocket chambers that were subjected to post-deposition treatments in an effort to densify the Ir coating. One chamber was vacuum annealed, while the other chamber was subjected to hot isostatic pressure (HIP). The chambers were tested on gaseous oxygen/gaseous hydrogen propellants, at mixture ratios that simulated the oxidizing environments of Earth-storable propellants. ne annealed ED Ir/PM Re chamber was tested for a total of 24 firings and 4.58 hr at a mixture ratio of 4.2. After only 9 firings, the annealed ED Ir coating began to blister and spall upstream of the throat. The blistering and spalling were similar to what had been experienced with unannealed, as-deposited ED Ir coatings. The HIP ED Ir/PM Re chamber was tested for a total of 91 firings and 11.45 hr at mixture ratios of 3.2 and 4.2. The HIP ED Ir coating remained adherent to the Re substrate throughout testing; there were no visible signs of coating degradation. Metallography revealed, however, thinning of the HIP Ir coating and occasional pores in the Re layer upstream of the throat. Pinholes in the Ir coating may have provided a path for oxidation of the Re substrate at these locations. The HIP ED Ir coating proved to be more effective than vacuum annealed and as-deposited ED Ir. Further densification is still required to

  2. Evaluation of oxide-coated iridium-rhenium chambers

    NASA Astrophysics Data System (ADS)

    Reed, Brian D.

    1994-03-01

    Iridium-coated rhenium (Ir-Re) provides long life operation of radiation-cooled rockets at temperatures up to 2200 C. Ceramic oxide coatings could be used to increase Ir-Re rocket lifetimes and allow operation in highly oxidizing environments. Ceramic oxide coatings promise to serve as both thermal and diffusion barriers for the iridium layer. Seven ceramic oxide-coated Ir-Re, 22-N rocket chambers were tested with gaseous hydrogen/gaseous oxygen (GHz/G02) propellants. Five chambers had thick (over 10 mils), monolithic coatings of either hafnia (HfO2) or zirconia (ZrO2). Two chambers had coatings with thicknesses less than 5 mils. One of these chambers had a thin-walled coating of ZrO2 infiltrated with sol gel HfO2. The other chamber had a coating composed of an Ir-oxide composite. The purpose of this test program was to assess the ability of the oxide coatings to withstand the thermal shock of combustion initiation, adhere under repeated thermal cycling, and operate in aggressively oxidizing environments. All of the coatings survived the thermal shock of combustion and demonstrated operation at mixture ratios up to 11. Testing the Ir-oxide composite-coated chamber included over 29 min at mixture ratio 16. The thicker walled coatings provided the larger temperature drops across the oxide layer (up to 570 C), but were susceptible to macrocracking and eventual chipping at a stress concentrator. The cracks apparently resealed during firing, under compression of the oxide layer. The thinner walled coatings did not experience the macrocracking and chipping of the chambers that was seen with the thick, monolithic coatings. However, burn-throughs in the throat region did occur in both of the thin-walled chambers at mixture ratios well above stoichiometric. The burn-throughs were probably the result of oxygen diffusion through the oxide coating that allowed the underlying Ir and Re layers to be oxidized. The results of this test program indicated that the thin-walled oxide

  3. 27 CFR 19.185 - Testing scale tanks for accuracy.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the scale must be conducted at least every 6 months and whenever the scale is adjusted or repaired. (b... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Testing scale tanks for... Requirements Tank Requirements § 19.185 Testing scale tanks for accuracy. (a) A proprietor who uses a...

  4. 27 CFR 19.185 - Testing scale tanks for accuracy.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the scale must be conducted at least every 6 months and whenever the scale is adjusted or repaired. (b... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Testing scale tanks for... Requirements Tank Requirements § 19.185 Testing scale tanks for accuracy. (a) A proprietor who uses a...

  5. 27 CFR 19.185 - Testing scale tanks for accuracy.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the scale must be conducted at least every 6 months and whenever the scale is adjusted or repaired. (b... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Testing scale tanks for... Requirements Tank Requirements § 19.185 Testing scale tanks for accuracy. (a) A proprietor who uses a...

  6. 27 CFR 19.185 - Testing scale tanks for accuracy.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the scale must be conducted at least every 6 months and whenever the scale is adjusted or repaired. (b... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Testing scale tanks for... Requirements Tank Requirements § 19.185 Testing scale tanks for accuracy. (a) A proprietor who uses a...

  7. 32 CFR 185.2 - Applicability and scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.2 Applicability and scope. This part: (a) Applies to the Office of the... and Primary Agency for Emergency Support Function #3, Public Works and Engineering, of the...

  8. 32 CFR 185.2 - Applicability and scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE DEFENSE SUPPORT OF CIVIL AUTHORITIES (DSCA) § 185.2 Applicability and scope. This part: (a) Applies to the Office of the... and Primary Agency for Emergency Support Function #3, Public Works and Engineering, of the...

  9. 46 CFR 185.352 - Ventilation of gasoline machinery spaces.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Ventilation of gasoline machinery spaces. 185.352... machinery spaces. The mechanical exhaust for the ventilation of a gasoline machinery space, required by § 182.460(a)(1)(ii) of this chapter, must be operated prior to starting gasoline engines for the...

  10. 46 CFR 185.352 - Ventilation of gasoline machinery spaces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Ventilation of gasoline machinery spaces. 185.352... machinery spaces. The mechanical exhaust for the ventilation of a gasoline machinery space, required by § 182.460(a)(1)(ii) of this chapter, must be operated prior to starting gasoline engines for the...

  11. 46 CFR 185.352 - Ventilation of gasoline machinery spaces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Ventilation of gasoline machinery spaces. 185.352... machinery spaces. The mechanical exhaust for the ventilation of a gasoline machinery space, required by § 182.460(a)(1)(ii) of this chapter, must be operated prior to starting gasoline engines for the...

  12. 49 CFR 572.185 - Thorax (upper torso) assembly.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Impact Crash Test Dummy, 50th Percentile Adult Male § 572.185 Thorax (upper torso) assembly. (a) The... for a full-body thorax impact test. (b) Individual rib drop test. For purposes of this test, the rib... the impacted side of the rib facing up; (iii) The drop test fixture contains a free fall guided...

  13. 22 CFR 18.5 - Interpretative standards; advisory opinions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EMPLOYMENT CONFLICT OF INTEREST Applicable Rules § 18.5 Interpretative standards; advisory opinions. (a) A..., either in interim or final form by the Office of Government Ethics and published at 5 CFR part 737. (b... Legal Adviser for Management to request an advisory opinion....

  14. 46 CFR 185.202 - Notice of casualty.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... in a marine casualty shall notify the nearest Sector Office, Marine Inspection Office, or Coast Guard... fire extinguishing systems, lifesaving equipment, auxiliary power generating equipment, or bilge... Regulations (CFR) part 1904. (c) Notice given as required by § 185.203 satisfies the requirement of...

  15. 46 CFR 185.202 - Notice of casualty.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... in a marine casualty shall notify the nearest Sector Office, Marine Inspection Office, or Coast Guard... fire extinguishing systems, lifesaving equipment, auxiliary power generating equipment, or bilge... Regulations (CFR) part 1904. (c) Notice given as required by § 185.203 satisfies the requirement of...

  16. 16 CFR 1.85 - Final environmental impact statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Final environmental impact statements. 1.85... Final environmental impact statements. (a) After the close of the comment period, the Bureau responsible for the matter will consider the comments received on the draft environmental impact statement...

  17. 16 CFR 1.85 - Final environmental impact statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Final environmental impact statements. 1.85... Final environmental impact statements. (a) After the close of the comment period, the Bureau responsible for the matter will consider the comments received on the draft environmental impact statement...

  18. 16 CFR 1.85 - Final environmental impact statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Final environmental impact statements. 1.85... Final environmental impact statements. (a) After the close of the comment period, the Bureau responsible for the matter will consider the comments received on the draft environmental impact statement...

  19. 16 CFR 1.85 - Final environmental impact statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Final environmental impact statements. 1.85... Final environmental impact statements. (a) After the close of the comment period, the Bureau responsible for the matter will consider the comments received on the draft environmental impact statement...

  20. 16 CFR 1.85 - Final environmental impact statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Final environmental impact statements. 1.85... Final environmental impact statements. (a) After the close of the comment period, the Bureau responsible for the matter will consider the comments received on the draft environmental impact statement...

  1. 12 CFR 18.5 - Alternative annual disclosure statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Board (12 CFR part 225). Such schedules must be comparable to the Call Report schedules enumerated in... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Alternative annual disclosure statements. 18.5... national bank having a class of securities registered pursuant to section 12 of the Securities Exchange...

  2. 12 CFR 18.5 - Alternative annual disclosure statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Board (12 CFR part 225). Such schedules must be comparable to the Call Report schedules enumerated in... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Alternative annual disclosure statements. 18.5... national bank having a class of securities registered pursuant to section 12 of the Securities Exchange...

  3. 12 CFR 18.5 - Alternative annual disclosure statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Board (12 CFR part 225). Such schedules must be comparable to the Call Report schedules enumerated in... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Alternative annual disclosure statements. 18.5... national bank having a class of securities registered pursuant to section 12 of the Securities Exchange...

  4. 40 CFR 98.185 - Procedures for estimating missing data.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Procedures for estimating missing data... PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Lead Production § 98.185 Procedures for estimating... such estimates. (a) For each missing data for the carbon content for the smelting furnaces at...

  5. 46 CFR 185.352 - Ventilation of gasoline machinery spaces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Ventilation of gasoline machinery spaces. 185.352... machinery spaces. The mechanical exhaust for the ventilation of a gasoline machinery space, required by... sufficient to insure at least one complete change of air in the space served....

  6. 50 CFR 216.185 - Requirements for monitoring.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Low Frequency Active (SURTASS LFA sonar) Sonar § 216.185 Requirements for monitoring. (a) In order to mitigate the taking of marine mammals by SURTASS LFA sonar to the greatest extent practicable, the Holder... sunset); (2) Use low frequency passive SURTASS sonar to listen for vocalizing marine mammals; and (3)...

  7. 50 CFR 216.185 - Requirements for monitoring.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Low Frequency Active (SURTASS LFA sonar) Sonar § 216.185 Requirements for monitoring. (a) In order to mitigate the taking of marine mammals by SURTASS LFA sonar to the greatest extent practicable, the Holder... sunset); (2) Use low frequency passive SURTASS sonar to listen for vocalizing marine mammals; and (3)...

  8. 22 CFR 18.5 - Interpretative standards; advisory opinions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... EMPLOYMENT CONFLICT OF INTEREST Applicable Rules § 18.5 Interpretative standards; advisory opinions. (a) A..., either in interim or final form by the Office of Government Ethics and published at 5 CFR part 737. (b... Legal Adviser for Management to request an advisory opinion....

  9. 185. Photographic copy of original construction drawing dated March 28, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    185. Photographic copy of original construction drawing dated March 28, 1932 (from Record Group 115, Denver Branch of the National Archives, Denver). VOLUME CHANGE IN MASS CONCRETE; OWYHEE DAM CONCRETE RESEARCH FOR HOOVER DAM; CONTRACTION JOINT METER INSTALLATION. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

  10. 46 CFR 185.202 - Notice of casualty.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... does not include the cost of salvage, cleaning, gas freeing, drydocking, or demurrage. (b) A vessel is... reporting requirements of the Occupational Safety and Health Administration (OSHA) in 29 Code of Federal Regulations (CFR) part 1904. (c) Notice given as required by § 185.203 satisfies the requirement of...

  11. 40 CFR 792.185 - Reporting of study results.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Reporting of study results. 792.185... study results. (a) A final report shall be prepared for each study and shall include, but not necessarily be limited to, the following: (1) Name and address of the facility performing the study and...

  12. 40 CFR 792.185 - Reporting of study results.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Reporting of study results. 792.185... study results. (a) A final report shall be prepared for each study and shall include, but not necessarily be limited to, the following: (1) Name and address of the facility performing the study and...

  13. Rhenium-coated glass beads for intracolonic administration attenuate TNBS-induced colitis in mice: Proof-of-Concept Study.

    PubMed

    Siczek, Krzysztof; Zatorski, Hubert; Pawlak, Wojciech; Fichna, Jakub

    2015-01-01

    In search for novel effective treatments in inflammatory bowel diseases, a new strategy employing glass beads coated with rhenium nanolayer has been developed and validated in the mouse model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Briefly, mice were randomly divided into 5 experimental groups: control (vehicle alone, Group 1); control treated with rhenium-coated glass beads (Group 2); TNBS (Group 3); TNBS treated with rhenium-coated glass beads (Group 4); and TNBS treated with uncoated glass beads (Group 5). Mice from Group 2, 4 and 5 were treated with respective beads (once daily, 5 beads / animal, i.c.) between D3-D6 post-TNBS/vehicle and evaluation of colonic damage was performed on D7, based on macroscopic scoring and clinical parameters. Severe colonic inflammation developed in post-TNBS mice (Group 3) [P <0.001 vs. control (Group 1) for macroscopic score], which was significantly attenuated by treatment with rhenium-coated glass beads (Group 4) [P <0.01 vs. TNBS (Group 3), for macroscopic score]. Neither rhenium-coated glass beads had any effect in control animals (Group 2), nor uncoated glass beads influenced TNBS-induced colitis (Group 5). In conclusion, a novel and attractive strategy for the treatment of colonic inflammation has been proposed; therapy with rhenium-coated glass beads already proved effective in the mouse model of TNBS-induced colitis, now requires further characterization in clinical conditions.

  14. Rhenium-coated glass beads for intracolonic administration attenuate TNBS-induced colitis in mice: Proof-of-Concept Study.

    PubMed

    Siczek, Krzysztof; Zatorski, Hubert; Pawlak, Wojciech; Fichna, Jakub

    2015-01-01

    In search for novel effective treatments in inflammatory bowel diseases, a new strategy employing glass beads coated with rhenium nanolayer has been developed and validated in the mouse model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Briefly, mice were randomly divided into 5 experimental groups: control (vehicle alone, Group 1); control treated with rhenium-coated glass beads (Group 2); TNBS (Group 3); TNBS treated with rhenium-coated glass beads (Group 4); and TNBS treated with uncoated glass beads (Group 5). Mice from Group 2, 4 and 5 were treated with respective beads (once daily, 5 beads / animal, i.c.) between D3-D6 post-TNBS/vehicle and evaluation of colonic damage was performed on D7, based on macroscopic scoring and clinical parameters. Severe colonic inflammation developed in post-TNBS mice (Group 3) [P <0.001 vs. control (Group 1) for macroscopic score], which was significantly attenuated by treatment with rhenium-coated glass beads (Group 4) [P <0.01 vs. TNBS (Group 3), for macroscopic score]. Neither rhenium-coated glass beads had any effect in control animals (Group 2), nor uncoated glass beads influenced TNBS-induced colitis (Group 5). In conclusion, a novel and attractive strategy for the treatment of colonic inflammation has been proposed; therapy with rhenium-coated glass beads already proved effective in the mouse model of TNBS-induced colitis, now requires further characterization in clinical conditions. PMID:26867119

  15. Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging.

    PubMed

    Olafsen, Tove; Kenanova, Vania E; Sundaresan, Gobalakrishnan; Anderson, Anne-Line; Crow, Desiree; Yazaki, Paul J; Li, Lin; Press, Michael F; Gambhir, Sanjiv S; Williams, Lawrence E; Wong, Jeffrey Y C; Raubitschek, Andrew A; Shively, John E; Wu, Anna M

    2005-07-01

    We have recently described the in vivo properties of an iodinated anti-p185HER2 engineered antibody fragment [minibody (scFv-C(H)3)2; 80 kDa], made from the internalizing 10H8 monoclonal antibody. Although the 10H8 minibody showed excellent binding to the target in vitro, only modest tumor uptake [5.6 +/- 1.7% injected dose per gram (ID/g) of tissue] was achieved in nude mice bearing MCF7/HER2 breast cancer tumors. Here, in an attempt to improve targeting, the 10H8 minibody was conjugated to 1,4,7,10-tetraazacyclododecane-N, N', N'', N'''-tetraacetic acid (DOTA), radiometal labeled, and evaluated in vivo. The tumor uptake of 111In-DOTA 10H8 minibody was 5.7 +/- 0.1% ID/g, similar to the radioiodinated 10H8 minibody. However, in addition to the expected liver clearance, the kidneys had unexpectedly high activity (34.0 +/- 4.0% ID/g). A minibody derived from a second anti-p185(HER2) antibody (trastuzumab; hu4D5v8) was also made. Tumor uptakes, evaluated by quantitative microPET using 64Cu-DOTA hu4D5v8 minibody, were 4.2 +/- 0.5% ID/g. Furthermore, in non-tumor-bearing mice, 111In-DOTA hu4D5v8 minibody exhibited similar elevated uptake in the kidneys (28.4 +/- 6.5% ID/g). Immunohistochemical staining of kidneys from non-tumor-bearing mice showed strong specific staining of the proximal tubules, and Western blot analysis of kidney lysate confirmed the presence of cross-reactive antigen. To further improve tumor uptake and normal tissue distribution, a larger hu4D5v8 fragment [(scFv-C(H)2-C(H)3)2; 105 kDa] was made, engineered to exhibit rapid clearance kinetics. This fragment, when evaluated by microPET, exhibited improved tumor targeting (12.2 +/- 2.4% ID/g) and reduced kidney uptake (13.1 +/- 1.5% ID/g). Thus, by manipulating the size and format of anti-p185(HER2) antibody fragments, the kidney activity was reduced and high or low expression of p185HER2 in xenografts could be distinguished by microPET imaging.

  16. Luminescent Rhenium(I) and Iridium(III) Polypyridine Complexes as Biological Probes, Imaging Reagents, and Photocytotoxic Agents.

    PubMed

    Lo, Kenneth Kam-Wing

    2015-12-15

    in the cytotoxic activity, cellular uptake, and bioimaging applications of these complexes. Additionally, we and other research groups have demonstrated that many transition metal complexes have facile cellular uptake and organelle-localization properties and that their cytotoxic activity can be readily controlled. For example, complexes that can target the nucleus, nucleolus, mitochondria, lysosomes, endoplasmic reticulum, and Golgi apparatus have been identified. We anticipate that this selective localization property can be utilized in the development of intracellular sensors and bioimaging reagents. Thus, we have functionalized luminescent rhenium(I) and iridium(III) polypyridine complexes with various pendants, including molecule-binding moieties, sugar molecules, bioorthogonal functional groups, and polymeric chains such as poly(ethylene glycol) and polyethylenimine, and examined their potentials as biological reagents. This Account describes our design of luminescent rhenium(I) and iridium(III) polypyridine complexes and explains how they can serve as a new generation of biological reagents for diagnostic and therapeutic applications.

  17. A chiral rhenium complex with predicted high parity violation effects: synthesis, stereochemical characterization by VCD spectroscopy and quantum chemical calculations.

    PubMed

    Saleh, Nidal; Zrig, Samia; Roisnel, Thierry; Guy, Laure; Bast, Radovan; Saue, Trond; Darquié, Benoît; Crassous, Jeanne

    2013-07-14

    With their rich electronic, vibrational, rotational and hyperfine structure, molecular systems have the potential to play a decisive role in precision tests of fundamental physics. For example, electroweak nuclear interactions should cause small energy differences between the two enantiomers of chiral molecules, a signature of parity symmetry breaking. Enantioenriched oxorhenium(VII) complexes S-(-)- and R-(+)-3 bearing a chiral 2-methyl-1-thio-propanol ligand have been prepared as potential candidates for probing molecular parity violation effects via high resolution laser spectroscopy of the Re=O stretching. Although the rhenium atom is not a stereogenic centre in itself, experimental vibrational circular dichroism (VCD) spectra revealed a surrounding chiral environment, evidenced by the Re=O bond stretching mode signal. The calculated VCD spectrum of the R enantiomer confirmed the position of the sulfur atom cis to the methyl, as observed in the solid-state X-ray crystallographic structure, and showed the presence of two conformers of comparable stability. Relativistic quantum chemistry calculations indicate that the vibrational shift between enantiomers due to parity violation is above the target sensitivity of an ultra-high resolution infrared spectroscopy experiment under active preparation.

  18. Efficient photovoltaic cells with wide photosensitization range fabricated from rhenium benzathiazole complexes

    NASA Astrophysics Data System (ADS)

    Wong, Hei Ling; Mak, Chris S. K.; Chan, Wai Kin; Djurišić, Aleksandra B.

    2007-02-01

    Bulk heterojunction ITO/CuPc/sensitizer:C60/C60/Al (ITO denotes indium tin oxide; CuPc denotes copper phthalocyanine) photovoltaic cells were fabricated by using rhenium(I) complexes with benzathiazole ligands as the sensitizers. The complexes enhance the photosensitivity in the region of 450-550nm in which CuPc and C60 have little absorption. The devices exhibited high fill factors in excess of 0.6, and the power conversion efficiency of the best device 1.72%. A device based on pure CuPc :C60 mixed layer was fabricated for comparison. The external quantum efficiency of the devices remained higher than 10% in the entire visible region, which clearly demonstrated the importance of rhenium complexes as sensitizers.

  19. Nanograined Net-Shaped Fabrication of Rhenium Components by EB-PVD

    SciTech Connect

    Singh, Jogender; Wolfe, Douglas E.

    2004-02-04

    Cost-effective net-shaped forming components have brought considerable interest into DoD, NASA and DoE. Electron beam physical vapor deposition (EB-PVD) offers flexibility in forming net-shaped components with tailored microstructure and chemistry. High purity rhenium (Re) components including rhenium-coated graphite balls, Re- plates and tubes have been successfully manufactured by EB-PVD. EB-PVD Re components exhibited sub-micron and nano-sized grains with high hardness and strength as compared to CVD. It is estimated that the cost of Re components manufactured by EB-PVD would be less than the current CVD and powder-HIP Technologies.

  20. Slip casting and extruding shapes of rhenium with metal oxide additives. 1: Feasibility demonstration

    NASA Technical Reports Server (NTRS)

    Barr, F. A.; Page, R. J.

    1986-01-01

    The feasibility of fabricating small rhenium parts with metal oxide additives by means of slip casting and extrusion techniques is described. The metal oxides, ZrO2 and HfO2 were stabilized into the cubic phase with Y2O3. Additions of metal oxide to the rhenium of up to 15 weight percent were used. Tubes of 17 mm diameter with 0.5 mm walls were slip cast by adapting current ceramic oxide techniques. A complete cast double conical nozzle demonstrated the ability to meet shapes and tolerances. Extrusion of meter long tubing lengths of 3.9 mm o.d. x 2.3 mm i.d. final dimension is documented. Sintering schedules are presented to produce better than 95% of theoretical density parts. Finished machining was found possible were requried by electric discharge machining and diamond grinding.

  1. Rhenium-osmium-isotope constraints on the age of iron meteorites

    NASA Technical Reports Server (NTRS)

    Horan, M. F.; Morgan, J. W.; Walker, R. J.; Grossman, J. N.

    1992-01-01

    Rhenium and osmium concentrations and the osmium isotopic compositions of iron meteorites were determined by negative thermal ionization mass spectrometry. Data for the IIA iron meteorites define an isochron with an uncertainty of approximately +/-31 million years for meteorites about 4500 million years old. Although an absolute rhenium-osmium closure age for this iron group cannot be as precisely constrained because of uncertainty in the decay constant of Re-187, an age of 4460 million years ago is the minimum permitted by combined uncertainties. These age constraints imply that the parent body of the IIAB magmatic irons melted and subsequently cooled within 100 million years after the formation of the oldest portions of chondrites. Other iron meteorites plot above the IIA isochron, indicating that the planetary bodies represented by these iron groups may have cooled significantly later than the parent body of the IIA irons.

  2. Rhenium-osmium isotope constraints on the age of iron meteorites

    USGS Publications Warehouse

    Horan, M.F.; Morgan, J.W.; Walker, R.J.; Grossman, J.N.

    1992-01-01

    Rhenium and osmium concentrations and the osmium isotopic compositions of iron meteorites were determined by negative thermal ionization mass spectrometry. Data for the IIA iron meteorites define an isochron with an uncertainty of approximately ??31 million years for meteorites ???4500 million years old. Although an absolute rhenium-osmium closure age for this iron group cannot be as precisely constrained because of uncertainty in the decay constant of 187Re, an age of 4460 million years ago is the minimum permitted by combined uncertainties. These age constraints imply that the parent body of the IIAB magmatic irons melted and subsequently cooled within 100 million years after the formation of the oldest portions of chondrites. Other iron meteorites plot above the IIA isochron, indicating that the planetary bodies represented by these iron groups may have cooled significantly later than the parent body of the IIA irons.

  3. Stability and mobility of rhenium and osmium in tungsten: first principles study

    NASA Astrophysics Data System (ADS)

    Suzudo, T.; Yamaguchi, M.; Hasegawa, A.

    2014-10-01

    We report a series of ab initio studies based upon density functional theory for the behavior of rhenium and osmium atoms in body-centered-cubic tungsten crystal. Contrary to the fast one-dimensional migration of self-interstitial atoms, interstitials of these solute elements in tungsten have three-dimensional motion because they form a mixed dumbbell having a low rotation energy barrier. The migration of these solute elements strongly influences the effects of radiation upon the materials, and our results suggest that the low rotation energy barrier leading to three-dimensional migration is a property that is key to the explanation of the radiation effects experimentally observed in tungsten-rhenium and tungsten-osmium alloys.

  4. Radiometabolic treatment of bone-metastasizing cancer: from 186rhenium to 223radium.

    PubMed

    Rubini, Giuseppe; Nicoletti, Adriano; Rubini, Domenico; Asabella, Artor Niccoli

    2014-02-01

    Skeletal metastases occur in many patients with different kinds of malignant tumors, especially in advance stage of breast cancer (in 47%-85% of patients), prostate cancer (33-85%), and lung cancer (32%-60%). The management of painful skeletal metastases is complicated and should be carried out by a multidisciplinary approach including conventional analgesics, antitumor therapy (chemo- and hormone therapy), osteoclast-inhibitory agents (bisphosphonates), corticosteroids, external-beam radiotherapy, surgery, and nuclear medicine therapy. The nuclear medicine therapy for palliation of pain from bone metastases is a systemic radionuclide therapy based on the use of radiopharmaceuticals. In several studies the efficacy of bone-seeking radiopharmaceuticals have been demonstrated in terms of pain reduction from diffuse skeletal metastases. In this review, we will summarize the current literature on bone-seeking radiopharmaceuticals for the treatment of painful bone metastases (Phosphorus-32, Strontium-89, Rhenium-186, Rhenium-188, Samarium-153, and Radium-223) and the combination therapy with biphosphonates and chemotherapy.

  5. Electrotransport and diffusivity of molybdenum, rhenium, tungsten, and zirconium in beta-thorium

    NASA Technical Reports Server (NTRS)

    Schmidt, F. A.; Beck, M. S.; Rehbein, D. K.; Conzemius, R. J.; Carlson, O. N.

    1984-01-01

    The electric mobilities, diffusivities, and effective valences were determined for molybdenum, rhenium, tungsten, and zirconium in beta-thorium. All four solutes migrated in the same direction as the electron flow. Rhenium and molybdenum were found to be very mobile, with tungsten somewhat slower. Zirconium was found to move at a rate near that of the self-diffusion of beta-thorium, viz., about 10 to the -11th sq m/s at 1500 C. The electromigration velocities showed a similar trend. A comparison was made between experimental data obtained by scanning laser mass spectrometry and theoretical transport equations for two purification experiments. Good agreement was obtained with both the concentration profile predicted by DeGroot and the purification ratio predicted by Verhoeven.

  6. Alkoxy bridged binuclear rhenium (I) complexes as a potential sensor for β-amyloid aggregation.

    PubMed

    Sathish, Veerasamy; Babu, Eththilu; Ramdass, Arumugam; Lu, Zong-Zhan; Velayudham, Murugesan; Thanasekaran, Pounraj; Lu, Kuang-Lieh; Rajagopal, Seenivasan

    2014-12-01

    Alkoxy bridged binuclear rhenium(I) complexes are used as a probe for the selective and sensitive detection of aggregation of β-amyloid fibrils that are consorted with Alzheimer's disease (AD). The strong binding of the complexes is affirmed by the fluorescence enhancement and calculated binding constant value in the order of 10(5)M(-1) is obtained from the Scatchard plots. The binding of β-amyloid can be attributed to π-π stacking interaction of naphthalene moiety present in rhenium(I) complexes, and it is supported by docking studies. The selectivity is quite high towards other proteins and the formation of fibrils can be observed in the range of 30-40 nm through the AFM and TEM techniques.

  7. Equation of state of rhenium and application for ultra high pressure calibration

    SciTech Connect

    Anzellini, Simone; Dewaele, Agnès; Occelli, Florent; Loubeyre, Paul; Mezouar, Mohamed

    2014-01-28

    The isothermal equation of state of rhenium has been measured by powder X-ray diffraction experiments up to 144 GPa at room temperature in a diamond anvil cell. A helium pressure transmitting medium was used to minimize the non-hydrostatic stress on the sample. The fit of pressure-volume data yields a bulk modulus K{sub 0} = 352.6 GPa and a pressure derivative of the bulk modulus K′{sub 0}=4.56. This equation of state differs significantly from a recent determination [Dubrovinsky et al., Nat. Commun. 3, 1163 (2012)], giving here a lower pressure at a given volume. The possibility of using rhenium gasket X-ray diffraction signal, with the present equation of state, to evaluate multi-Mbar pressures in the chamber of diamond anvil cells is discussed.

  8. Crystallization and rhenium MAD phasing of the acyl-homoserinelactone synthase EsaI

    SciTech Connect

    Watson, W.T.; Murphy IV, Frank V.; Gould, Ty A.; Jambeck, Per; Val, Dale L.; Cronan, Jr., John E.; Beck von Bodman, Susan; Churchill, Mair E.A.

    2009-04-22

    Acyl-homoserine-L-lactones (AHLs) are diffusible chemical signals that are required for virulence of many Gram-negative bacteria. AHLs are produced by AHL synthases from two substrates, S-adenosyl-L-methionine and acyl-acyl carrier protein. The AHL synthase EsaI, which is homologous to the AHL synthases from other pathogenic bacterial species, has been crystallized in the primitive tetragonal space group P4{sub 3}, with unit-cell parameters a = b = 66.40, c = 47.33 {angstrom}. The structure was solved by multiple-wavelength anomalous diffraction with a novel use of the rhenium anomalous signal. The rhenium-containing structure has been refined to a resolution of 2.5 {angstrom} and the perrhenate ion binding sites and liganding residues have been identified.

  9. Rhenium Solubility in Borosilicate Nuclear Waste Glass: Implications for the Processing and Immobilization of Technetium-99

    SciTech Connect

    McCloy, John S.; Riley, Brian J.; Goel, Ashutosh; Liezers, Martin; Schweiger, Michael J.; Rodriguez, Carmen P.; Hrma, Pavel R.; Kim, Dong-Sang; Lukens, Wayne W.; Kruger, Albert A.

    2012-10-26

    The immobilization of 99Tc in a suitable host matrix has proved to be an arduous task for the researchers in nuclear waste community around the world. At the Hanford site in Washington State, the total amount of 99Tc in low-activity waste (LAW) is ~1300 kg and the current strategy is to immobilize the 99Tc in borosilicate glass with vitrification. In this context, the present article reports on the solubility/retention of rhenium, a nonradioactive surrogate for 99Tc, in a LAW borosilicate glass. Due to the radioactive nature of technetium, rhenium was chosen as a simulant because of the similarity between their ionic radii and other chemical aspects. The glasses containing Re (0 – 10,000 ppm by mass) were synthesized in vacuum-sealed quartz ampoules in order to minimize the loss of Re by volatilization during melting at 1000 °C. The rhenium was found to predominantly exist as Re (VII) in all the glasses as observed by X-ray absorption near-edge structure (XANES). The solubility of Re in borosilicate glasses was determined to be ~3000 ppm (by mass) with inductively coupled plasma-optical emission spectroscopy (ICP-OES). At higher rhenium concentrations, some additional material was retained in the glasses in the form of crystalline inclusions that were detected by X-ray diffraction (XRD) and laser ablation-ICP mass spectrometry (LA-ICP-MS). The implications of these results on the immobilization of 99Tc from radioactive wastes in borosilicate glasses have been discussed.

  10. Observation of a Burstein-Moss shift in rhenium-doped MoS2 nanoparticles.

    PubMed

    Sun, Qi-C; Yadgarov, Lena; Rosentsveig, Rita; Seifert, Gotthard; Tenne, Reshef; Musfeldt, Janice L

    2013-04-23

    We investigated the optical properties of rhenium-doped MoS2 nanoparticles and compared our findings with the pristine and bulk analogues. Our measurements reveal that confinement softens the exciton positions and reduces spin-orbit coupling, whereas doping has the opposite effect. We model the carrier-induced exciton blue shift in terms of the Burstein-Moss effect. These findings are important for understanding doping and finite length scale effects in low-dimensional nanoscale materials.

  11. Sulfur-bonded thiophenes in organometallic rhenium complexes and adsorption of isocyanides on gold

    SciTech Connect

    Robertson, M.J.

    1993-08-01

    This dissertation contains results of research conducted in two different areas: (1) organometallic synthesis and reactivity, and (2) organometallic surface chemistry. In the synthesis and reactivity studies, sulfur coordination of thiophene and benzo[b]thiophene to the metal center in organometallic rhenium complexes is examined. In the surface chemistry studies, diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) is used to analyze the adsorption of several isocyanides on the surface of gold powder. Results are compared and contrasted to known organometallic chemistry.

  12. Broad Detection Range Rhenium Diselenide Photodetector Enhanced by (3-Aminopropyl)Triethoxysilane and Triphenylphosphine Treatment.

    PubMed

    Jo, Seo-Hyeon; Park, Hyung-Youl; Kang, Dong-Ho; Shim, Jaewoo; Jeon, Jaeho; Choi, Seunghyuk; Kim, Minwoo; Park, Yongkook; Lee, Jaehyeong; Song, Young Jae; Lee, Sungjoo; Park, Jin-Hong

    2016-08-01

    The effects of triphenylphosphine and (3-aminopropyl)triethoxysilane on a rhenium diselenide (ReSe2 ) photodetector are systematically studied by comparing with conventional MoS2 devices. This study demonstrates a very high performance ReSe2 photodetector with high photoresponsivity (1.18 × 10(6) A W(-1) ), fast photoswitching speed (rising/decaying time: 58/263 ms), and broad photodetection range (possible above 1064 nm).

  13. Broad Detection Range Rhenium Diselenide Photodetector Enhanced by (3-Aminopropyl)Triethoxysilane and Triphenylphosphine Treatment.

    PubMed

    Jo, Seo-Hyeon; Park, Hyung-Youl; Kang, Dong-Ho; Shim, Jaewoo; Jeon, Jaeho; Choi, Seunghyuk; Kim, Minwoo; Park, Yongkook; Lee, Jaehyeong; Song, Young Jae; Lee, Sungjoo; Park, Jin-Hong

    2016-08-01

    The effects of triphenylphosphine and (3-aminopropyl)triethoxysilane on a rhenium diselenide (ReSe2 ) photodetector are systematically studied by comparing with conventional MoS2 devices. This study demonstrates a very high performance ReSe2 photodetector with high photoresponsivity (1.18 × 10(6) A W(-1) ), fast photoswitching speed (rising/decaying time: 58/263 ms), and broad photodetection range (possible above 1064 nm). PMID:27167366

  14. Evidence for the abundant expression of arginine 185 containing human CRF(2alpha) receptors and the role of position 185 for receptor-ligand selectivity.

    PubMed

    Dautzenberg, F M; Huber, G; Higelin, J; Py-Lang, G; Kilpatrick, G J

    2000-06-01

    The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated. His(185) has only been reported in hCRF(2); CRF(2) proteins from other species and all CRF(1) receptors encode an arginine (Arg(185)) at the corresponding position. Cloning of partial and full-length hCRF(2) cDNAs from a variety of neuronal and peripheral tissues revealed the existence of receptor molecules encoding Arg(185) only. Sequence analysis of the hCRF(2) gene verified the existence of Arg(185) also on genomic level. Full-length cDNAs encoding either the His(185) (R2H(185)) or the Arg(185) (R2R(185)) variants of hCRF(2alpha) were stably expressed in HEK293 cells and tested for ligand binding properties. In displacement studies R2H(185) and R2R(185) displayed a similar substrate specificity, human and rat urocortin, and the peptide antagonists astressin and alpha-helical CRF((9-41)) were bound with high affinity whereas human and ovine CRF were low-affinity ligands. Significant differences were observed for sauvagine and urotensin I, which bound with 3-fold (sauvagine) and 9-fold (urotensin I) higher affinity to R2R(185). These data indicate that hCRF(2), like all vertebrate CRF(1) and CRF(2) proteins encodes an arginine residue at the junction between extracellular domain 2 and transmembrane domain 3 and that this amino acid plays a role for the discrimination of some CRF peptide ligands.

  15. Evidence for the abundant expression of arginine 185 containing human CRF(2alpha) receptors and the role of position 185 for receptor-ligand selectivity.

    PubMed

    Dautzenberg, F M; Huber, G; Higelin, J; Py-Lang, G; Kilpatrick, G J

    2000-06-01

    The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated. His(185) has only been reported in hCRF(2); CRF(2) proteins from other species and all CRF(1) receptors encode an arginine (Arg(185)) at the corresponding position. Cloning of partial and full-length hCRF(2) cDNAs from a variety of neuronal and peripheral tissues revealed the existence of receptor molecules encoding Arg(185) only. Sequence analysis of the hCRF(2) gene verified the existence of Arg(185) also on genomic level. Full-length cDNAs encoding either the His(185) (R2H(185)) or the Arg(185) (R2R(185)) variants of hCRF(2alpha) were stably expressed in HEK293 cells and tested for ligand binding properties. In displacement studies R2H(185) and R2R(185) displayed a similar substrate specificity, human and rat urocortin, and the peptide antagonists astressin and alpha-helical CRF((9-41)) were bound with high affinity whereas human and ovine CRF were low-affinity ligands. Significant differences were observed for sauvagine and urotensin I, which bound with 3-fold (sauvagine) and 9-fold (urotensin I) higher affinity to R2R(185). These data indicate that hCRF(2), like all vertebrate CRF(1) and CRF(2) proteins encodes an arginine residue at the junction between extracellular domain 2 and transmembrane domain 3 and that this amino acid plays a role for the discrimination of some CRF peptide ligands. PMID:10818253

  16. Mechanisms for CO production from CO2 using reduced rhenium tricarbonyl catalysts.

    PubMed

    Agarwal, Jay; Fujita, Etsuko; Schaefer, Henry F; Muckerman, James T

    2012-03-21

    The chemical conversion of CO(2) has been studied by numerous experimental groups. Particularly the use of rhenium tricarbonyl-based molecular catalysts has attracted interest owing to their ability to absorb light, store redox equivalents, and convert CO(2) into higher-energy products. The mechanism by which these catalysts mediate reduction, particularly to CO and HCOO(-), is poorly understood, and studies aimed at elucidating the reaction pathway have likely been hindered by the large number of species present in solution. Herein the mechanism for carbon monoxide production using rhenium tricarbonyl catalysts has been investigated using density functional theory. The investigation presented proceeds from the experimental work of Meyer's group (J. Chem. Soc., Chem. Commun.1985, 1414-1416) in DMSO and Fujita's group (J. Am. Chem. Soc.2003, 125, 11976-11987) in dry DMF. The latter work with a simplified reaction mixture, one that removes the photo-induced reduction step with a sacrificial donor, is used for validation of the proposed mechanism, which involves formation of a rhenium carboxylate dimer, [Re(dmb)(CO)(3)](2)(OCO), where dmb = 4,4'-dimethyl-2,2'-bipyridine. CO(2) insertion into this species, and subsequent rearrangement, is proposed to yield CO and the carbonate-bridged [Re(dmb)(CO)(3)](2)(OCO(2)). Structures and energies for the proposed reaction path are presented and compared to previously published experimental observations. PMID:22364649

  17. Technetium and rhenium pentacarbonyl complexes with C₂ and C₁₁ ω-isocyanocarboxylic acid esters.

    PubMed

    Miroslavov, Alexander E; Polotskii, Yuriy S; Gurzhiy, Vladislav V; Ivanov, Alexander Yu; Lumpov, Alexander A; Tyupina, Margarita Yu; Sidorenko, Georgy V; Tolstoy, Peter M; Maltsev, Daniil A; Suglobov, Dmitry N

    2014-08-01

    Technetium(I) and rhenium(I) pentacarbonyl complexes with ethyl 2-isocyanoacetate and methyl 11-isocyanoundecanoate, [M(CO)5(CNCH2COOEt)]ClO4 (M = Tc (1) and Re (2)) and [M(CO)5(CN(CH2)10COOMe)]ClO4 (M = Tc (3) and Re (4)), were prepared and characterized by IR, (1)H NMR, and (13)C{(1)H} NMR spectroscopy. The crystal structures of 1 and 2 were determined using single-crystal X-ray diffraction. The kinetics of thermal decarbonylation of technetium complexes 1 and 3 in ethylene glycol was studied by IR spectroscopy. The rate constants and activation parameters of this reaction were determined and compared with those for [Tc(CO)6](+). It was found that rhenium complexes 2 and 4 were stable with respect to thermal decarbonylation. Histidine challenge reaction of complexes 1 and 2 in phosphate buffer was examined by IR spectroscopy. In the presence of histidine, the rhenium pentacarbonyl isocyanide complex partially decomposes to form an unidentified yellow precipitate. Technetium analogue 1 is more stable under these conditions.

  18. Mono- and Dinuclear Phosphorescent Rhenium(I) Complexes: Impact of Subcellular Localization on Anticancer Mechanisms.

    PubMed

    Ye, Rui-Rong; Tan, Cai-Ping; Chen, Mu-He; Hao, Liang; Ji, Liang-Nian; Mao, Zong-Wan

    2016-06-01

    Elucidation of relationship among chemical structure, cellular uptake, localization, and biological activity of anticancer metal complexes is important for the understanding of their mechanisms of action. Organometallic rhenium(I) tricarbonyl compounds have emerged as potential multifunctional anticancer drug candidates that can integrate therapeutic and imaging capabilities in a single molecule. Herein, two mononuclear phosphorescent rhenium(I) complexes (Re1 and Re2), along with their corresponding dinuclear complexes (Re3 and Re4), were designed and synthesized as potent anticancer agents. The subcellular accumulation of Re1-Re4 was conveniently analyzed by confocal microscopy in situ in live cells by utilizing their intrinsic phosphorescence. We found that increased lipophilicity of the bidentate ligands could enhance their cellular uptake, leading to improved anticancer efficacy. The dinuclear complexes were more potent than the mononuclear counterparts. The molecular anticancer mechanisms of action evoked by Re3 and Re4 were explored in detail. Re3 with a lower lipophilicity localizes to lysosomes and induces caspase-independent apoptosis, whereas Re4 with higher lipophilicity specially accumulates in mitochondria and induces caspase-independent paraptosis in cancer cells. Our study demonstrates that subcellular localization is crucial for the anticancer mechanisms of these phosphorescent rhenium(I) complexes. PMID:27106876

  19. Mono- and Dinuclear Phosphorescent Rhenium(I) Complexes: Impact of Subcellular Localization on Anticancer Mechanisms.

    PubMed

    Ye, Rui-Rong; Tan, Cai-Ping; Chen, Mu-He; Hao, Liang; Ji, Liang-Nian; Mao, Zong-Wan

    2016-06-01

    Elucidation of relationship among chemical structure, cellular uptake, localization, and biological activity of anticancer metal complexes is important for the understanding of their mechanisms of action. Organometallic rhenium(I) tricarbonyl compounds have emerged as potential multifunctional anticancer drug candidates that can integrate therapeutic and imaging capabilities in a single molecule. Herein, two mononuclear phosphorescent rhenium(I) complexes (Re1 and Re2), along with their corresponding dinuclear complexes (Re3 and Re4), were designed and synthesized as potent anticancer agents. The subcellular accumulation of Re1-Re4 was conveniently analyzed by confocal microscopy in situ in live cells by utilizing their intrinsic phosphorescence. We found that increased lipophilicity of the bidentate ligands could enhance their cellular uptake, leading to improved anticancer efficacy. The dinuclear complexes were more potent than the mononuclear counterparts. The molecular anticancer mechanisms of action evoked by Re3 and Re4 were explored in detail. Re3 with a lower lipophilicity localizes to lysosomes and induces caspase-independent apoptosis, whereas Re4 with higher lipophilicity specially accumulates in mitochondria and induces caspase-independent paraptosis in cancer cells. Our study demonstrates that subcellular localization is crucial for the anticancer mechanisms of these phosphorescent rhenium(I) complexes.

  20. Diverse roles of hydrogen in rhenium carbonyl chemistry: hydrides, dihydrogen complexes, and a formyl derivative.

    PubMed

    Li, Nan; Xie, Yaoming; King, R Bruce; Schaefer, Henry F

    2010-11-01

    Rhenium carbonyl hydride chemistry dates back to the 1959 synthesis of HRe(CO)₅ by Hieber and Braun. The binuclear H₂Re₂(CO)₈ was subsequently synthesized as a stable compound with a central Re₂(μ-H)₂ unit analogous to the B₂(μ-H)₂ unit in diborane. The complete series of HRe(CO)(n) (n = 5, 4, 3) and H₂Re₂(CO)(n) (n = 9, 8, 7, 6) derivatives have now been investigated by density functional theory. In contrast to the corresponding manganese derivatives, all of the triplet rhenium structures are found to lie at relatively high energies compared with the corresponding singlet structures consistent with the higher ligand field splitting of rhenium relative to manganese. The lowest energy HRe(CO)₅ structure is the expected octahedral structure. Low-energy structures for HRe(CO)(n) (n = 4, 3) are singlet structures derived from the octahedral HRe(CO)₅ structure by removal of one or two carbonyl groups. For H₂Re₂(CO)₉ a structure HRe₂(CO)₉(μ-H), with one terminal and one bridging hydrogen atom, lies within 3 kcal/mol of the structure Re₂(CO)₉(η²-H₂), similar to that of Re₂(CO)₁₀. For H₂Re₂(CO)(n) (n = 8, 7, 6) the only low-energy structures are doubly bridged singlet Re₂(μ-H)₂(CO)(n) structures. Higher energy dihydrogen complex structures are also found.

  1. Characterization of rhenium compounds obtained by electrochemical synthesis after aging process

    SciTech Connect

    Vargas-Uscategui, Alejandro; Mosquera, Edgar; López-Encarnación, Juan M.; Chornik, Boris; Katiyar, Ram S.; Cifuentes, Luis

    2014-12-15

    The proper identification of the molecular nature of the aged rhenium compound obtained by means of electrodeposition from an alkaline aqueous electrolyte was determined. Chemical, structural and vibrational experimental characterization of the aged Re compound showed agreement with quantum-computations, thereby allowing the unambiguous identification of the Re compound as H(ReO{sub 4})H{sub 2}O. - Graphical abstract: Rhenium oxides were electrodeposited on a copper surface and after environmental aging was formed the H(ReO{sub 4})H{sub 2}O compound. The characterization of the synthesized material was made through the comparison of experimental evidence with quantum mechanical computations carried out by means of density functional theory (DFT). - Highlights: • Aged rhenium compound obtained by means of electrodeposition was studied. • The study was made by combining experimental and DFT-computational information. • The aged electrodeposited material is consistent with the H(ReO{sub 4})H{sub 2}O compound.

  2. In house development of (99m)Tc-Rhenium sulfide colloidal nanoparticles for sentinel lymph node detection.

    PubMed

    Dar, Ume-Kalsoom; Khan, Irfanullah; Javed, Muhammad; Ali, Muhammad; Hyder, Syed Waqar; Murad, Sohail; Anwar, Jamil

    2013-03-01

    In this study, rhenium sulfide colloidal nanoparticles were developed as radiopharmaceutical for sentinel lymph node detection. We directly used rhenium sulfide as a starting material for the preparation of colloidal nanoparticles. UV-visible spectrophotometry was used for characterization of in house developed colloidal particles. The size distribution of radioactive particles was studied by using membrane filtration method. The percentage of radiolabeled colloidal nanoparticles was determined by paper chromatography (PC). The study also includes in vitro stability, protein binding in human blood and bioevaluation in a rabbit model. The results indicate that 77.27 ± 3.26 % particles of size less than 20nm (suitable for lymphoscintigraphy) were radiolabeled. (99m)Tc labeled rhenium sulfide labeling efficacy with the radiometal is 98.5 ± 0.5%, which remains considerably stable beyond 5h at room temperature. Furthermore, it was observed that 70.2 ± 1.3% radiolabeled colloid complex showed binding with the blood protein. Bioevaluation results show the remarkable achievement of our radiopharmaceutical. The in house prepared (99m)Tc labeled rhenium sulfide colloidal nanoparticles reached the sentinel node within 15 min of post injection. These results indicate that (99m)Tc labeled rhenium sulfide colloid nanoparticles kit produced by a novel procedure seems of significant potential as a feasible candidate for further development to be used in clinical practice.

  3. 41 CFR 102-85.185 - Can space be exempted from the standard levels of service

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Can space be exempted from the standard levels of service 102-85.185 Section 102-85.185 Public Contracts and Property... PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Standard Levels of Service § 102-85.185 Can space...

  4. 41 CFR 102-85.185 - Can space be exempted from the standard levels of service

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Can space be exempted from the standard levels of service 102-85.185 Section 102-85.185 Public Contracts and Property... PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Standard Levels of Service § 102-85.185 Can space...

  5. 42 CFR 416.185 - Process for establishing a new class of new technology IOLs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... technology IOLs. 416.185 Section 416.185 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.185 Process for establishing a new class of new technology IOLs. (a) Announcement of deadline...

  6. 42 CFR 416.185 - Process for establishing a new class of new technology IOLs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... technology IOLs. 416.185 Section 416.185 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.185 Process for establishing a new class of new technology IOLs. (a) Announcement of deadline...

  7. 42 CFR 416.185 - Process for establishing a new class of new technology IOLs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technology IOLs. 416.185 Section 416.185 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.185 Process for establishing a new class of new technology IOLs. (a) Announcement of deadline for requests...

  8. 24 CFR 990.185 - Utilities expense level: Incentives for energy conservation/rate reduction.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Calculating Formula Expenses § 990.185 Utilities expense level: Incentives for energy conservation/rate reduction. (a) General/consumption reduction. If a PHA undertakes energy conservation measures that are... for energy conservation/rate reduction. 990.185 Section 990.185 Housing and Urban...

  9. 46 CFR 185.730 - Servicing of inflatable liferafts, inflatable buoyant apparatus, inflatable life jackets, and...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... inflatable liferaft or inflatable buoyant apparatus must be serviced at a facility specifically approved by... apparatus, inflatable life jackets, and inflated rescue boats. 185.730 Section 185.730 Shipping COAST GUARD... Operational Readiness, Maintenance, and Inspection of Lifesaving Equipment § 185.730 Servicing of...

  10. 46 CFR 185.730 - Servicing of inflatable liferafts, inflatable buoyant apparatus, inflatable life jackets, and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... inflatable liferaft or inflatable buoyant apparatus must be serviced at a facility specifically approved by... apparatus, inflatable life jackets, and inflated rescue boats. 185.730 Section 185.730 Shipping COAST GUARD... Operational Readiness, Maintenance, and Inspection of Lifesaving Equipment § 185.730 Servicing of...

  11. 5 CFR 185.140 - Stays ordered by the Department of Justice.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Stays ordered by the Department of Justice. 185.140 Section 185.140 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.140 Stays ordered by the Department of Justice. If, at any...

  12. 5 CFR 185.140 - Stays ordered by the Department of Justice.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Stays ordered by the Department of Justice. 185.140 Section 185.140 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.140 Stays ordered by the Department of Justice. If, at any...

  13. 5 CFR 185.140 - Stays ordered by the Department of Justice.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Stays ordered by the Department of Justice. 185.140 Section 185.140 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.140 Stays ordered by the Department of Justice. If, at any...

  14. 5 CFR 185.140 - Stays ordered by the Department of Justice.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Stays ordered by the Department of Justice. 185.140 Section 185.140 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.140 Stays ordered by the Department of Justice. If, at any...

  15. 5 CFR 185.140 - Stays ordered by the Department of Justice.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Stays ordered by the Department of Justice. 185.140 Section 185.140 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.140 Stays ordered by the Department of Justice. If, at any...

  16. 5 CFR 185.103 - Basis for civil penalties and assessments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Basis for civil penalties and assessments. 185.103 Section 185.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.103 Basis for civil penalties and assessments. (a) In...

  17. 46 CFR 185.210 - Alcohol or drug use by individuals directly involved in casualties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Alcohol or drug use by individuals directly involved in casualties. 185.210 Section 185.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Marine Casualties and Voyage Records § 185.210 Alcohol or drug use by individuals...

  18. 12 CFR 303.185 - Merger transactions involving foreign banks or foreign organizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Merger transactions involving foreign banks or foreign organizations. 303.185 Section 303.185 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES International Banking § 303.185 Merger...

  19. 46 CFR 185.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Abandon ship and man overboard drills and training. 185.520 Section 185.520 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.520 Abandon ship and man overboard drills and training. (a) The...

  20. 46 CFR 185.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Abandon ship and man overboard drills and training. 185.520 Section 185.520 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.520 Abandon ship and man overboard drills and training. (a) The...

  1. 46 CFR 185.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Abandon ship and man overboard drills and training. 185.520 Section 185.520 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.520 Abandon ship and man overboard drills and training. (a) The...

  2. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Academy of Sciences or the National Academy of Public Administration? § 102-3.185 What does this... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What does this subpart require agencies to do? 102-3.185 Section 102-3.185 Public Contracts and Property Management...

  3. 40 CFR 408.185 - Standards of performance for new sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Standards of performance for new sources. 408.185 Section 408.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Hand-Butchered Salmon Processing Subcategory § 408.185 Standards of performance for new sources....

  4. 24 CFR 990.185 - Utilities expense level: Incentives for energy conservation/rate reduction.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... for energy conservation/rate reduction. 990.185 Section 990.185 Housing and Urban Development... Calculating Formula Expenses § 990.185 Utilities expense level: Incentives for energy conservation/rate reduction. (a) General/consumption reduction. If a PHA undertakes energy conservation measures that...

  5. 24 CFR 990.185 - Utilities expense level: Incentives for energy conservation/rate reduction.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... for energy conservation/rate reduction. 990.185 Section 990.185 Housing and Urban Development... Calculating Formula Expenses § 990.185 Utilities expense level: Incentives for energy conservation/rate reduction. (a) General/consumption reduction. If a PHA undertakes energy conservation measures that...

  6. A reusable unsupported rhenium nanocrystalline catalyst for acceptorless dehydrogenation of alcohols through γ-C-H activation.

    PubMed

    Yi, Jing; Miller, Jeffrey T; Zemlyanov, Dmitry Y; Zhang, Ruihong; Dietrich, Paul J; Ribeiro, Fabio H; Suslov, Sergey; Abu-Omar, Mahdi M

    2014-01-13

    Rhenium nanocrystalline particles (Re NPs), of 2 nm size, were prepared from NH4ReO4 under mild conditions in neat alcohol. The unsupported Re NPs convert secondary and benzylic alcohols to ketones and aldehydes, respectively, through catalytic acceptorless dehydrogenation (AD). The oxidant- and acceptor-free neat dehydrogenation of alcohols to obtain dihydrogen gas is a green and atom-economical process for making carbonyl compounds. Secondary aliphatic alcohols give quantitative conversion and yield. Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Re K-edge X-ray absorption near-edge structure (XANES), and X-ray absorption fine structure (EXAFS) data confirmed the characterization of the Re NPs as metallic rhenium with surface oxidation to rhenium(IV) oxide (ReO2). Isotope labeling experiments revealed a novel γ-CH activation mechanism for AD of alcohols. PMID:24282107

  7. First Science with SAMI: A Serendipitously Discovered Galactic Wind in ESO 185-G031

    NASA Astrophysics Data System (ADS)

    Fogarty, Lisa M. R.; Bland-Hawthorn, Joss; Croom, Scott M.; Green, Andrew W.; Bryant, Julia J.; Lawrence, Jon S.; Richards, Samuel; Allen, James T.; Bauer, Amanda E.; Birchall, Michael N.; Brough, Sarah; Colless, Matthew; Ellis, Simon C.; Farrell, Tony; Goodwin, Michael; Heald, Ron; Hopkins, Andrew M.; Horton, Anthony; Jones, D. Heath; Lee, Steve; Lewis, Geraint; López-Sánchez, Ángel R.; Miziarski, Stan; Trowland, Holly; Leon-Saval, Sergio G.; Min, Seong-Sik; Trinh, Christopher; Cecil, Gerald; Veilleux, Sylvain; Kreimeyer, Kory

    2012-12-01

    We present the first scientific results from the Sydney-AAO Multi-Object IFS (SAMI) at the Anglo-Australian Telescope. This unique instrument deploys 13 fused fiber bundles (hexabundles) across a one-degree field of view allowing simultaneous spatially resolved spectroscopy of 13 galaxies. During the first SAMI commissioning run, targeting a single galaxy field, one object (ESO 185-G031) was found to have extended minor axis emission with ionization and kinematic properties consistent with a large-scale galactic wind. The importance of this result is twofold: (1) fiber bundle spectrographs are able to identify low surface brightness emission arising from extranuclear activity and (2) such activity may be more common than presently assumed because conventional multi-object spectrographs use single-aperture fibers and spectra from these are nearly always dominated by nuclear emission. These early results demonstrate the extraordinary potential of multi-object hexabundle spectroscopy in future galaxy surveys.

  8. Highly anisotropic rhenium(IV) complexes: new examples of mononuclear single-molecule magnets.

    PubMed

    Martínez-Lillo, José; Mastropietro, Teresa F; Lhotel, Elsa; Paulsen, Carley; Cano, Joan; De Munno, Giovanni; Faus, Juan; Lloret, Francesc; Julve, Miguel; Nellutla, Saritha; Krzystek, J

    2013-09-18

    The rhenium(IV) complex (NBu4)2[ReBr4(ox)] (1) (ox = oxalate and NBu4(+) = tetra-n-butylammonium cation) has been prepared and its crystal structure determined by X-ray diffraction. The structure is made up of discrete [ReBr4(ox)](2-) anions and bulky NBu4(+) cations. Each [ReBr4(ox)](2-) anion is surrounded by six NBu4(+) cations, which preclude any significant intermolecular contact between the anionic entities, the shortest rhenium···rhenium distance being 9.373(1) Å. Variable temperature dc and ac magnetic susceptibility measurements and field-dependent magnetization experiments on polycrystalline samples of 1 reveal the occurrence of highly anisotropic magnetically isolated Re(IV) centers (S(Re) = 3/2), which exhibit slow relaxation of the magnetization at very low temperatures in a dc field. Ac measurements conducted on a polycrystalline sample of the complex (NBu4)2[ReCl4(ox)] (2) [compound isostructural to 1 whose structure and dc magnetic susceptibility study were previously reported in Tomkiewicz, A.; Bartczak, T. J.; Kruszyński, R.; Mroziński, J. J. Mol. Struct. 2001, 595, 225] show a similar behavior, both complexes thus constituting new examples of mononuclear single-molecule magnets. High-frequency and -field electron paramagnetic resonance on polycrystalline samples of 1 and 2 and on single crystals of 2 allowed for the determination for the first time of the negative sign and confirmed a significant magnitude and rhombicity (E/D) of the zero-field splitting tensor of the [ReCl4(ox)](2-) and [ReBr4(ox)](2-) centers, originating from a combination of spin-orbit coupling and low molecular symmetry. D and E values of 1 and 2 were estimated through magnetization measurements and theoretically calculated through complete active space and density functional theory methodologies.

  9. A recombinant Sp185/333 protein from the purple sea urchin has multitasking binding activities towards certain microbes and PAMPs.

    PubMed

    Lun, Cheng Man; Schrankel, Catherine S; Chou, Hung-Yen; Sacchi, Sandro; Smith, L Courtney

    2016-08-01

    The purple sea urchin, Strongylocentrotus purpuratus, possesses a sophisticated innate immune system that responds to microbes effectively by swift expression of the highly diverse Sp185/333 gene family. The Sp185/333 proteins are predicted to have anti-pathogen functions based on inducible gene expression and their significant sequence diversity. Sp185/333 proteins are all predicted to be intrinsically disordered and do not exhibit sequence similarities to other known proteins. To test the anti-pathogen hypothesis, a recombinant Sp185/333 protein, rSp0032, was evaluated and found to exhibit specific binding to marine Vibrio diazotrophicus and to Saccharomyces cerevisiae, but not to two Bacillus species. rSp0032 also binds to LPS, β-1,3-glucan and flagellin but not to peptidoglycan. rSp0032 binding to LPS can be competed by LPS, β-1,3-glucan and flagellin but not by peptidoglycan. We speculate that the predicted intrinsically disordered structure of rSp0032 may adapt to different conformations in binding to a limited number of PAMPs and pathogens. Given that rSp0032 binds to a range of targets, and that up to 260 different Sp185/333 proteins can be expressed per individual sea urchin, this family of immune response proteins may facilitate effective host protection against a broad array of potential pathogens encountered in the marine environment.

  10. A recombinant Sp185/333 protein from the purple sea urchin has multitasking binding activities towards certain microbes and PAMPs.

    PubMed

    Lun, Cheng Man; Schrankel, Catherine S; Chou, Hung-Yen; Sacchi, Sandro; Smith, L Courtney

    2016-08-01

    The purple sea urchin, Strongylocentrotus purpuratus, possesses a sophisticated innate immune system that responds to microbes effectively by swift expression of the highly diverse Sp185/333 gene family. The Sp185/333 proteins are predicted to have anti-pathogen functions based on inducible gene expression and their significant sequence diversity. Sp185/333 proteins are all predicted to be intrinsically disordered and do not exhibit sequence similarities to other known proteins. To test the anti-pathogen hypothesis, a recombinant Sp185/333 protein, rSp0032, was evaluated and found to exhibit specific binding to marine Vibrio diazotrophicus and to Saccharomyces cerevisiae, but not to two Bacillus species. rSp0032 also binds to LPS, β-1,3-glucan and flagellin but not to peptidoglycan. rSp0032 binding to LPS can be competed by LPS, β-1,3-glucan and flagellin but not by peptidoglycan. We speculate that the predicted intrinsically disordered structure of rSp0032 may adapt to different conformations in binding to a limited number of PAMPs and pathogens. Given that rSp0032 binds to a range of targets, and that up to 260 different Sp185/333 proteins can be expressed per individual sea urchin, this family of immune response proteins may facilitate effective host protection against a broad array of potential pathogens encountered in the marine environment. PMID:27020848

  11. Investigation of activation cross-section data of proton induced nuclear reactions on rhenium.

    PubMed

    Ditrói, F; Tárkányi, F; Takács, S; Hermanne, A; Yamazaki, H; Baba, M; Mohammadi, A; Ignatyuk, A V

    2013-07-01

    In the frame of systematic investigations of activation cross-section data for different applications the excitation functions of (nat)Re(p,x)(185)Os, (183m)Os, (183g)Os, (182)Os, (181m)Os, (186g)Re, (184m)Re, (184g)Re, (183)Re, (182m)Re, (182g)Re and (181g)Re reactions were measured up to 70MeV. The data for the (nat)Re(p,x) (183m)Os, (183g)Os, (182)Os, (181g)Os,(186g)Re, (184m)Re,(182m)Re, (182g)Re, and (181)Re reactions are reported for the first time. The activation method, the stacked foil irradiation technique and γ-spectroscopy for activity detection were used. The experimental data were compared with predictions of three theoretical codes. From the measured cross-section thick target integral yields were also calculated and presented.

  12. Direct radiometric dating of hydrocarbon deposits using rhenium-osmium isotopes.

    PubMed

    Selby, David; Creaser, Robert A

    2005-05-27

    Rhenium-osmium (Re-Os) data from migrated hydrocarbons establish the timing of petroleum emplacement for the giant oil sand deposits of Alberta, Canada, at 112 +/- 5.3 million years ago. This date does not support models that invoke oil generation and migration for these deposits in the Late Cretaceous. Most Re-Os data from a variety of deposits within the giant hydrocarbon system show similar characteristics, supporting the notion of a single source for these hydrocarbons. The Re-Os data disqualify Cretaceous rocks as the primary hydrocarbon source but suggest an origin from older source rocks. This approach should be applicable to dating oil deposits worldwide.

  13. Theoretical Investigations on the Elastic and Thermodynamic Properties of Rhenium Phosphide

    NASA Astrophysics Data System (ADS)

    Wei, Qun; Yan, Haiyan; Zhu, Xuanmin; Lin, Zhengzhe; Yao, Ronghui

    2016-01-01

    Structural, mechanical, and electronic properties of orthorhombic rhenium phosphide (Re2P) are systematically investigated by using first principles calculations. The elastic constants and anisotropy of elastic properties are obtained. The metallic character of Re2P is demonstrated by density of state calculations. The quasi-harmonic Debye model is applied to the study of the thermodynamic properties. The thermal expansion, heat capacities, and Grüneisen parameter on the temperature and pressure have been determined as a function of temperature and pressure in the pressure range from 0 to 100 GPa and the temperature range from 0 to 1600 K.

  14. Superconducting molybdenum-rhenium electrodes for single-molecule transport studies

    SciTech Connect

    Gaudenzi, R.; Island, J. O.; Bruijckere, J. de; Burzurí, E.; Zant, H. S. J. van der; Klapwijk, T. M.

    2015-06-01

    We demonstrate that electronic transport through single molecules or molecular ensembles, commonly based on gold (Au) electrodes, can be extended to superconducting electrodes by combining gold with molybdenum-rhenium (MoRe). This combination induces proximity-effect superconductivity in the gold to temperatures of at least 4.6 K and magnetic fields of 6 T, improving on previously reported aluminum based superconducting nanojunctions. As a proof of concept, we show three-terminal superconductive transport measurements through an individual Fe{sub 4} single-molecule magnet.

  15. Testing and evaluation of oxide-coated iridium/rhenium chambers

    NASA Technical Reports Server (NTRS)

    Reed, Brian D.

    1993-01-01

    Iridium-coated rhenium provides long life operation of radiation-cooled rockets at temperatures up to 2200 C. Ceramic oxide coatings could be used to increase iridium/rhenium rocket lifetimes and allow operation in highly oxidizing environments. Ceramic oxide coatings promise to serve as both thermal and diffusion barriers for the iridium layer. Seven ceramic oxide-coated iridium/rhenium, 22 N rocket chambers were tested on gaseous hydrogen/gaseous oxygen propellants. Five chambers had thick (over 10 mils), monolithic coatings of either hafnia or zirconia. Two chambers had coatings with thicknesses less than 5 mils. One of these chambers had a thin-walled coating of zirconia infiltrated with sol gel hafnia. The other chamber had a coating composed of an iridium/oxide composite. The purpose of this test program was to assess the ability of the oxide coatings to withstand the thermal shock of combustion initiation, adhere under repeated thermal cycling, and operate in aggressively oxidizing environments. All of the coatings survived the thermal shock of combustion and demonstrated operation at mixture ratios up to 11. The iridium/oxide composite coated chamber included testing for over 29 minutes at mixture ratio 16. The thicker-walled coatings provided the larger temperature drops across the oxide layer (up to 570 C), but were susceptible to macrocracking and eventual chipping at a stress concentrator. The cracks apparently resealed during firing, under compression of the oxide layer. The thinner-walled coatings did not experience the macrocracking and chipping of the chambers seen with the thick, monolithic coatings. However, burnthroughs in the throat region did occur in both of the thin-walled chambers at mixture ratios well above stochiometric. The burn-throughs were probably the result of oxygen-diffusion through the oxide coating that allowed the underlying iridium and rhenium layers to be oxidized. The results of this test program indicated that the thin

  16. Selective LXR{alpha} inhibitory effects observed in plant extracts of MEH184 (Parthenocissua tricuspidata) and MEH185 (Euscaphis japonica)

    SciTech Connect

    Kim, Kang Ho; Choi, Seung Hyun; Lee, Thomas S.; Oh, Won Keun; Kim, Dong Sun; Kim, Jae Bum . E-mail: jaebkim@snu.ac.kr

    2006-10-20

    Liver X receptors (LXRs) are nuclear hormone receptors that behave as lipid sensors of cellular cholesterol and fatty acid. Although LXR activation can alleviate hypercholesterolemia by inducing cholesterol efflux, it also results in undesirable effects of fatty acid synthesis, resulting in hepatic steatosis and hyperlipidemia. Therefore, it is critical to identify LXR{alpha} inhibitory agents that would repress fatty acid synthesis and hepatic lipid accumulation. In current study, screening of plant extracts used for traditional oriental medicine resulted in the identification of two candidates demonstrating selective LXR{alpha} inhibitory activity. These were whole leaf methanol extracts of Parthenocissua tricuspidata (MEH184) and Euscaphis japonica (MEH185). Both MEH184 and MEH185 decreased transcriptional activity of LXR{alpha} and the expression of LXR{alpha} target genes, such as FAS and ADD1/SREBP1c. Additionally, MEH184 and MEH184 significantly reduced lipogenesis and adipocyte differentiation. Together, the data imply that MEH184 and MEH185 possess selective antagonistic properties on LXR{alpha} to downregulate lipogenesis.

  17. Screening for 185delAG in the Ashkenazim.

    PubMed Central

    Richards, C S; Ward, P A; Roa, B B; Friedman, L C; Boyd, A A; Kuenzli, G; Dunn, J K; Plon, S E

    1997-01-01

    A study was initiated to assess interest, educational effectiveness, and implications of genetic testing for the common BRCA1 mutation, 185delAG, in the Ashkenazim. Of 333 individuals who attended group sessions, 309 (92%) participated in the study. Participants were categorized as having negative family history (67%), positive family history (defined, by a relaxed criterion, as one first-degree relative or two second-degree relatives with breast [premenopausal] or ovarian cancer) (22%), positive personal history (7%), and both positive personal history and positive family history (4%). Group education was effective, as shown by the improvement in participant scores from pre- to posteducation tests. For the 289 individuals (94%) who requested testing, the major reasons included concern for their own risk, concern for the risk of their children, and desire to learn about surveillance options. The most common reason given by participants who declined testing was concern about health insurance. Six participants found to be heterozygous for the 185delAG mutation received results and were offered genetic counseling. Participants had consented for additional testing without receiving results and were screened for the 6174delT mutation in BRCA2, and seven were found to be positive. All identified carriers reported at least one first- or second-degree relative with a history of breast or ovarian cancer, although they did not all meet our study criteria for positive family history. Given these outcomes, we conclude that screening for breast and ovarian cancer susceptibility is most appropriate for individuals with a positive personal or positive family cancer history. We propose a guideline for future studies designed to identify individuals who may benefit from genetic testing for inherited breast and ovarian cancer. Images Figure 1 PMID:9150156

  18. MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein

    PubMed Central

    Li, Min; Wang, Qi; Liu, Shun-Ai; Zhang, Jin-Qian; Ju, Wei; Quan, Min; Feng, Sheng-Hu; Dong, Jin-Ling; Gao, Ping; Cheng, Jun

    2015-01-01

    AIM: To investigate the molecular mechanism for regulation of cholesterol metabolism by hepatitis C virus (HCV) core protein in HepG2 cells. METHODS: HCV genotype 1b core protein was cloned and expressed in HepG2 cells. The cholesterol content was determined after transfection. The expression of sterol regulatory element binding protein 2 (SREBP2) and the rate-limiting enzyme in cholesterol synthesis (HMGCR) was measured by quantitative real-time PCR and immunoblotting after transfection. The effects of core protein on the SREBP2 promoter and 3’-untranslated region were analyzed by luciferase assay. We used different target predictive algorithms, microRNA (miRNA) mimics/inhibitors, and site-directed mutation to identify a putative target of a particular miRNA. RESULTS: HCV core protein expression in HepG2 cells increased the total intracellular cholesterol level (4.05 ± 0.17 vs 6.47 ± 0.68, P = 0.001), and this increase corresponded to an increase in SREBP2 and HMGCR mRNA levels (P = 0.009 and 0.037, respectively) and protein expression. The molecular mechanism study revealed that the HCV core protein increased the expression of SREBP2 by enhancing its promoter activity (P = 0.004). In addition, miR-185-5p expression was tightly regulated by the HCV core protein (P = 0.041). Moreover, overexpression of miR-185-5p repressed the SREBP2 mRNA level (P = 0.022) and protein expression. In contrast, inhibition of miR-185-5p caused upregulation of SREBP2 protein expression. miR-185-5p was involved in the regulation of SREBP2 expression by HCV core protein. CONCLUSION: HCV core protein disturbs the cholesterol homeostasis in HepG2 cells via the SREBP2 pathway; miR-185-5p is involved in the regulation of SREBP2 by the core protein. PMID:25914460

  19. Deep red to near-infrared emitting rhenium(I) complexes: synthesis, characterization, electrochemistry, photophysics, and electroluminescence studies.

    PubMed

    Yu, Tao; Tsang, Daniel Ping-Kuen; Au, Vonika Ka-Man; Lam, Wai Han; Chan, Mei-Yee; Yam, Vivian Wing-Wah

    2013-09-27

    A series of triarylamine-containing tricarbonyl rhenium(I) complexes, [BrRe(CO)3 (N^N)] (N^N=5,5'-bis(N,N-diaryl-4-[ethen-1-yl]-aniline)-2,2'-bipyridine), has been designed and synthesized by introducing a rhenium(I) metal center into a donor-π-acceptor-π-donor structure. All of the complexes showed an intense broad structureless emission band in dichloromethane at around 680-708 nm, which originated from an excited state of intraligand charge transfer ((3)ILCT) character from the triarylamine to the bipyridine moiety. Upon introduction of the bulky and electron-donating pentaphenylbenzene units attached to the aniline groups, the emission bands were found to be red shifted. The nanosecond transient absorption spectra of two selected complexes were studied, which were suggestive of the formation of an initial charge-separated state. Computational studies have been performed to provide further insight into the origin of the absorption and emission. One of the rhenium(I) complexes has been utilized in the fabrication of organic light-emitting diodes (OLEDs), representing the first example of the realization of deep red to near-infrared rhenium(I)-based OLEDs with an emission extending up to 800 nm. PMID:23959682

  20. Design, analysis, and fabrication of oxide-coated iridium/rhenium combustion chambers

    NASA Astrophysics Data System (ADS)

    Jang, Q.; Tuffias, R. H.; Laferla, R.; Ghoniem, N. M.

    1993-11-01

    Iridium-coated rhenium (Ir/Re) combustion chambers provide high temperature, oxidation-resistant operation for radiation-cooled liquid-fueled rocket engines. A 22-N (5-lb(sub f)) chamber has been operated for 15 hours at 2200 C (4000 F) using nitrogen tetroxide/monomethyl hydrazine (NTO/MMH) propellant, with negligible internal erosion. The oxidation resistance of these chambers could be further increased by the addition of refractory oxide coatings, providing longer life and/or operation in more oxidizing and higher temperature environments. The oxide coatings would serve as a thermal and diffusion barrier for the iridium coating, lowering the temperature of the iridium layer while also preventing the ingress of oxygen and egress of iridium oxides. This would serve to slow the failure mechanisms of Ir/Re chambers, namely the diffusion of rhenium to the inner surface and the oxidation of iridium. Such protection could extend chamber lifetimes by tens or perhaps hundreds of hours, and allow chamber operation on stoichiometric or higher mixture ratio oxygen/hydrogen (O2/H2) propellant. Extensive thermomechanical, thermochemical, and mass transport modeling was performed as a key material/structure design tool. Based on the results of these analyses, several 22-N oxide-coated Ir/Re chambers were fabricated and delivered to NASA Lewis Research Center for hot-fire testing.

  1. Crystallization of rhenium salts in a simulated low-activity waste borosilicate glass

    SciTech Connect

    Riley, Brian J.; McCloy, John S.; Goel, Ashutosh; Liezers, Martin; Schweiger, Michael J.; Liu, Juan; Rodriguez, Carmen P.; Kim, Dong-Sang

    2013-04-01

    This study presents a new method for looking at the solubility of volatile species in simulated low-activity waste glass. The present study looking at rhenium salts is also applicable to real applications involving radioactive technetium salts. In this synthesis method, oxide glass powder is mixed with the volatiles species, vacuum-sealed in a fused quartz ampoule, and then heat-treated under vacuum in a furnace. This technique restricts the volatile species to the headspace above the melt but still within the sealed ampoule, thus maximizing the volatile concentration in contact with the glass. Various techniques were used to measure the solubility of rhenium in glass and include energy dispersive spectroscopy, wavelength dispersive spectroscopy, laser ablation inductively-coupled plasma mass spectroscopy, and inductively-coupled plasma optical emission spectroscopy. The Re-solubility in this glass was determined to be ~3004 parts per million Re atoms. Above this concentration, the salts separated out of the melt as inclusions and as a low viscosity molten salt phase on top of the melt observed during and after cooling. This salt phase was analyzed with X-ray diffraction, scanning electron microscopy as well as some of the other aforementioned techniques and identified to be composed of alkali perrhenate and alkali sulfate.

  2. Rhenium volatilisation as caesium perrhenate from simulated vitrified high level waste from a melter crucible

    SciTech Connect

    Taylor, T.A.; Short, R.J.; Gribble, N.R.; Roe, J.I.; Steele, C.J.

    2013-07-01

    The Waste Vitrification Plant (WVP) converts Highly Active Liquor (HAL) from spent nuclear fuel reprocessing into a stable vitrified product. Recently WVP have been experiencing accumulation of solids in their primary off gas (POG) system leading to potential blockages. Chemical analysis of the blockage material via Laser Induced Breakdown Spectroscopy (LIBS) has shown it to exclusively consist of caesium, technetium and oxygen. The solids are understood to be caesium pertechnetate (CsTcO{sub 4}), resulting from the volatilisation of caesium and technetium from the high level waste glass melt. Using rhenium as a chemical surrogate for technetium, a series of full scale experiments have been performed in order to understand the mechanism of rhenium volatilisation as caesium perrhenate (CsReO{sub 4}), and therefore technetium volatilisation as CsTcO{sub 4}. These experiments explored the factors governing volatilisation rates from the melt, potential methods of minimising the amount of volatilisation, and various strategies for mitigating the deleterious effects of the volatile material on the POG. This paper presents the results from those experiments, and discusses potential methods to minimise blockages that can be implemented on WVP, so that the frequency of the CsTcO{sub 4} blockages can be reduced or even eradicated altogether. (authors)

  3. Linker conjugation effects in rhenium(I) bifunctional hole-transport/emitter molecules.

    PubMed

    Cleland, Deidre M; Irwin, Garth; Wagner, Pawel; Officer, David L; Gordon, Keith C

    2009-01-01

    Spectroscopic, electrochemical and density functional theory (DFT) methods have been employed to investigate a group of [Re(CO)(3)(HT)(phen)](+) complexes (phen = 1,10-phenanthroline), and in particular the level of electronic communication between various hole-transporting (HT) ligands and the rhenium centre. Here, the HT ligand consists of a coordinating pyridine connected to dimethylaniline group through a single-, double- or triple-bond-connecting system. Electronic absorption, resonance Raman, and steady-state emission spectroscopy combined with lifetime studies and DFT calculations suggest that multiple dpi(Re)-->pi*(phen) metal-to-ligand charge transfers (MLCTs) exist for each complex, two of which significantly absorb at about 340 and 385 nm, and one that emits at approximately 540 nm. In the complexes containing more-conjugated HT ligands, non-emissive intraligand transitions (IL(HT)) exist with energies between the ground and MLCT excited states. The overlap of these IL(HT) transitions and the absorbing MLCT of lowest energy deactivates emission resulting from about 385 nm excitation, and lowers the quantum yield and excited-state lifetimes of these complexes. Cyclic voltammetry experiments indicate that throughout the series investigated, the highest occupied molecular orbital (HOMO) of each complex is centred on the HT ligand, while the occupied molecular orbitals localised on the rhenium are lower in energy.

  4. Computer acquired performance data from a chemically vapor-deposited-rhenium, niobium planar diode

    NASA Technical Reports Server (NTRS)

    Manista, E. J.; Morris, J. F.; Smith, A. L.; Lancashire, R. B.

    1973-01-01

    Performance data from a chemically vapor-deposited-rhenium, niobium thermionic converter are presented. The planar converter has a guard-ringed collector and a nominal fixed spacing of 0.25 mm (10 mils). The data were obtained by using a computerized acquisition system and are available on request to one of the authors on microfiche as individual and composite parametric current, voltage curves. The parameters are the temperatures of the emitter T sub E collector T sub C, and cesium reservoir T sub R. The composite plots have constant T sub E and varying T sub C or T sub R, or both. Current, voltage envelopes having constant T sub E with and without fixed T sub C appear in the present report. The diode was tested at increments between 1600 and 2000 K for the emitter Hohlraum, 800 to 1100 K for the collector, and 540 and 650 K for the reservoir. A total of 312 current, voltage curves were obtained in the present performance evaluation. Current, voltage envelopes from three rhenium emitter converters evaluated in the present program are also given. The data are compared at commom emitter Hohlraum temperatures.

  5. Design, analysis, and fabrication of oxide-coated iridium/rhenium combustion chambers

    NASA Technical Reports Server (NTRS)

    Jang, Q.; Tuffias, R. H.; Laferla, R.; Ghoniem, N. M.

    1993-01-01

    Iridium-coated rhenium (Ir/Re) combustion chambers provide high temperature, oxidation-resistant operation for radiation-cooled liquid-fueled rocket engines. A 22-N (5-lb(sub f)) chamber has been operated for 15 hours at 2200 C (4000 F) using nitrogen tetroxide/monomethyl hydrazine (NTO/MMH) propellant, with negligible internal erosion. The oxidation resistance of these chambers could be further increased by the addition of refractory oxide coatings, providing longer life and/or operation in more oxidizing and higher temperature environments. The oxide coatings would serve as a thermal and diffusion barrier for the iridium coating, lowering the temperature of the iridium layer while also preventing the ingress of oxygen and egress of iridium oxides. This would serve to slow the failure mechanisms of Ir/Re chambers, namely the diffusion of rhenium to the inner surface and the oxidation of iridium. Such protection could extend chamber lifetimes by tens or perhaps hundreds of hours, and allow chamber operation on stoichiometric or higher mixture ratio oxygen/hydrogen (O2/H2) propellant. Extensive thermomechanical, thermochemical, and mass transport modeling was performed as a key material/structure design tool. Based on the results of these analyses, several 22-N oxide-coated Ir/Re chambers were fabricated and delivered to NASA Lewis Research Center for hot-fire testing.

  6. Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate.

    PubMed

    Gasser, Gilles; Pinto, Antonio; Neumann, Sebastian; Sosniak, Anna M; Seitz, Michael; Merz, Klaus; Heumann, Rolf; Metzler-Nolte, Nils

    2012-02-28

    A new rhenium tricarbonyl complex of a bis(quinoline)-derived ligand (2-azido-N,N-bis((quinolin-2-yl)methyl)ethanamine, L-N(3)), namely [Re(CO)(3)(L-N(3))]Br was synthesized and characterized in-depth, including by X-ray crystallography. [Re(CO)(3)(L-N(3))]Br exhibits a strong UV absorbance in the range 300-400 nm with a maximum at 322 nm, and upon photoexcitation, shows two distinct emission bands at about 430 and 560 nm in various solvents (water, ethylene glycol). [Re(CO)(3)(L-N(3))]Br could be conjugated, on a solid phase, to a peptide nucleic acid (PNA) oligomer using the copper(I)-catalyzed azide-alkyne cycloaddition reaction (Cu-AAC, "click" chemistry) and an alkyne-containing PNA building block to give Re-PNA. It was demonstrated that upon hybridisation with a complementary DNA strand (DNA), the position of the maxima and emission intensity for the hybrid Re-PNA·DNA remained mainly unchanged compared to those of the single strand Re-PNA. The rhenium-containing PNA oligomer Re-PNA could be then mediated in living cells where they have been shown to be non-toxic contrary to the general notion that organometallic compounds are usually unstable under physiological conditions and/or cytotoxic. Furthermore, Re-PNA could be detected in living cells using fluorescent microscopy.

  7. Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer.

    PubMed

    Collery, Philippe; Mohsen, Ahmed; Kermagoret, Anthony; Corre, Samantha; Bastian, Gérard; Tomas, Alain; Wei, Ming; Santoni, François; Guerra, Nadia; Desmaële, Didier; d'Angelo, Jean

    2015-08-01

    Rhenium (I)-diselenother (Re-diselenoether) is a water soluble metal-based compound, combining one atom of rhenium and two atoms of selenium. This compound has been reported to exhibit marked activities against several solid tumor cell lines. We now disclose an improved synthesis of this complex. The Re-diselenoether showed a potent inhibitory effect on MDA-MB231 cell division in vitro, which lasted when the complex was no longer present in the culture. Re-diselenoether induced a remarkable reduction of the volume of the primitive breast tumors and of the pulmonary metastases without clinical signs of toxicity, in mice-bearing a MDA-MB231 Luc+ tumor, orthotopically transplanted, after a daily oral administration at the dose of 10 mg/kg/d. Interestingly, an antagonism was observed when cisplatin was administered as a single i.p. injection 1 week after the end of the Re-diselenoether administration. In an effort to gain insight of the mechanisms of action of Re-diselenoether complex, interaction with 9-methylguanine as a nucleic acid base model was studied. We have shown that Re-diselenoether gave both mono- and bis-guanine Re adducts, the species assumed to be responsible for the DNA intrastrand lesions.

  8. [Antioxidant properties of cluster rhenium compounds and their effect on erythropoiesis of rats with guerin carcinoma].

    PubMed

    Voronkova, Y S; Babiy, S O; Ivans'kar, L V; Shtemenko, O V; Shtemenko, N I

    2015-01-01

    Biochemical characteristics of kidneys, pe- ripheral blood and bone marrow of rats in model of tumor growth under introduction of cisplatin and cis-tetrachlorodi-μ-isobutyratodirhenium(III), cis-Re2(i-C3H7COO)2Cl4 (I) have been investigated. It was shown that introduction of I alone and together with cisplatin led to decrease of biochemical markers of oxidation of lipids and proteins in tissue homogenates of the kidneys, change of enzyme activity in the urea and tissue homogenates of the kidneys, by a decrease of filtration function of kidneys. Introduction of nanoliposomal forms of the rhenium cluster compound led to a practically normal morphological picture of bone marrow and increase of the RBC (by 60%) with normalization of hematocrit counts, and decrease of quantities of destructed RBC (3.2 times) in comparison with the tumor-bearing animals. A tentative scheme of influence of cluster rhenium compound on erythropoiesis through regulation of synthesis of erythropoietin in kidneys has been proposed.

  9. 40 CFR 417.185 - Standards of performance for new sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.185 Standards of performance for new sources. The...

  10. 40 CFR 417.185 - Standards of performance for new sources.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.185 Standards of performance for new sources. The...

  11. 40 CFR 417.185 - Standards of performance for new sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.185 Standards of performance for new sources. The...

  12. 40 CFR 417.185 - Standards of performance for new sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.185 Standards of performance for new sources. The...

  13. 40 CFR 417.185 - Standards of performance for new sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.185 Standards of performance for new sources. The...

  14. A hexadentate bis(thiosemicarbazonato) ligand: rhenium(V), iron(III) and cobalt(III) complexes.

    PubMed

    Paterson, Brett M; White, Jonathan M; Donnelly, Paul S

    2010-03-21

    A new 1,3-diaminopropane bridged bis(thiosemicarbazone) ligand (H(4)L) has been synthesised. The new hexadentate ligand is capable of forming six coordinate complexes with rhenium(V), iron(III) and cobalt(III). In the case of the iron(III) and cobalt(III) complexes the ligand doubly deprotonates to give the monocations [Fe(III)(H(2)L)](+) and [Co(III)(H(2)L)](+) in which the metal ion is in a distorted octahedral environment. In the rhenium(V) complex the ligand loses four protons by deprotonation of both secondary amine nitrogen atoms to give [Re(V)(L)](+) with the metal ion in a distorted trigonal prismatic coordination environment. [Re(V)(L)](+) represents a rare example of a rhenium(V) complex that does not contain one of the ReO(3+), ReN(2+) or Re(NPh)(2+) cores. The new ligand and metal complexes have been characterised by a combination of NMR spectroscopy, X-ray crystallography, mass spectrometry and microanalysis. The electrochemistry of [Fe(III)(H(2)L)](+), [Co(III)(H(2)L)](+) and [Re(V)(L)](+) has been investigated by cyclic voltammetry with each complex undergoing a single electron reduction event. It is possible to prepare the rhenium(V) complex from ReOCl(3)(PPh(3))(2) or directly from [ReO(4)](-) with the addition of a reductant, which suggests the new ligand may be of interest in the development of rhenium radiopharmaceuticals.

  15. Rhenium(I)-Catalyzed Generation of α,β-Unsaturated Carbene Complex Intermediates from Propargyl Ethers for the Preparation of Cycloheptadiene Derivatives.

    PubMed

    Sogo, Hideyuki; Iwasawa, Nobuharu

    2016-08-16

    The rhenium(I)-catalyzed generation of α,β-unsaturated carbene complex intermediates from easily available propargyl ethers was achieved for the concise construction of cycloheptadiene derivatives through the formal [4+3] cycloaddition reaction with siloxydienes. PMID:27391557

  16. Radiation trapping of the Hg 185 nm resonance line

    NASA Astrophysics Data System (ADS)

    Menningen, K. L.; Lawler, J. E.

    2000-09-01

    The decay rate of the Hg 61P1 level was measured as a function of cold spot temperature (Hg density) and buffer gas pressure in cylindrical, sealed fused silica cells. The decay rates were obtained using a time-resolved laser-induced 185 nm fluorescence experiment with multi-step excitation. Cold spot temperatures from 25 to 100 °C were studied. The Hg densities for this temperature range and with no buffer gas yield the lowest possible decay rates due to radiation trapping with partial frequency redistribution. Decay rates with argon buffer gas pressures of 3 and 30 Torr were also studied. The results are in agreement with published data from a discharge afterglow experiment. Monte Carlo simulations of radiation transport in the cells, including the effects of hyperfine and isotope structure, the effects of foreign gas broadening, and partial frequency redistribution are compared to the experimental data. Reasonably good agreement is obtained, however there is evidence of quenching of Hg 61P1 atoms in collisions with ground state Hg and Ar atoms. An analytic formula for the fundamental mode trapped decay rate of the 61P1 level, which is applicable over a substantial region of parameter space, was devised from the Monte Carlo results.

  17. The Structures of the C185S and C185A Mutants of Sulfite Oxidase Reveal Rearrangement of the Active Site

    SciTech Connect

    Qiu, James A.; Wilson, Heather L.; Pushie, M. Jake; Kisker, Caroline; George, Graham N.; Rajagopalan, K.V.

    2010-11-03

    Sulfite oxidase (SO) catalyzes the physiologically critical conversion of sulfite to sulfate. Enzymatic activity is dependent on the presence of the metal molybdenum complexed with a pyranopterin-dithiolene cofactor termed molybdopterin. Comparison of the amino acid sequences of SOs from a variety of sources has identified a single conserved Cys residue essential for catalytic activity. The crystal structure of chicken liver sulfite oxidase indicated that this residue, Cys185 in chicken SO, coordinates the Mo atom in the active site. To improve our understanding of the role of this residue in the catalytic mechanism of sulfite oxidase, serine and alanine variants at position 185 of recombinant chicken SO were generated. Spectroscopic and kinetic studies indicate that neither variant is capable of sulfite oxidation. The crystal structure of the C185S variant was determined to 1.9 {angstrom} resolution and to 2.4 {angstrom} resolution in the presence of sulfite, and the C185A variant to 2.8 {angstrom} resolution. The structures of the C185S and C185A variants revealed that neither the Ser or Ala side chains appeared to closely interact with the Mo atom and that a third oxo group replaced the usual cysteine sulfur ligand at the Mo center, confirming earlier extended X-ray absorption fine structure spectroscopy (EXAFS) work on the human C207S mutant. An unexpected result was that in the C185S variant, in the absence of sulfite, the active site residue Tyr322 became disordered as did the loop region flanking it. In the C185S variant crystallized in the presence of sulfite, the Tyr322 residue relocalized to the active site. The C185A variant structure also indicated the presence of a third oxygen ligand; however, Tyr322 remained in the active site. EXAFS studies of the Mo coordination environment indicate the Mo atom is in the oxidized Mo{sup VI} state in both the C185S and C185A variants of chicken SO and show the expected trioxodithiolene active site. Density

  18. Effect of Iron and Carbonation of the Diffusion of Iodine and Rhenium in Waste Encasement Concrete and Soil Fill Material under Hydraulically Unsaturated Conditions

    SciTech Connect

    Wellman, Dawn M.; Parker, Kent E.; Powers, Laura; Whyatt, Greg A.; Clayton, Libby N.; Mattigod, Shas V.; Wood, Marcus I.

    2008-07-31

    Assessing long-term performance of Category 3 cement wasteforms and accurate prediction for radionuclide encasement requires knowledge of the radionuclide-cement interactions and mechanisms of retention (i.e. sorption or precipitation). A set of sediment-concrete half-cell diffusion experiments was conducted under unsaturated conditions (4% and 7% by weight moisture content) using carbonated and non-carbonated concrete-soil half-cells. Results indicate the behavior of rhenium and iodine release was comparable within a given half-cell test. Diffusivity in soil is a function of moisture content; a 3% increase in moisture content affords a one to two order of magnitude increase in diffusivity. Release of iodine and rhenium was 1 to 3 orders of magnitude less from non-carbonated, relative to carbonated, concrete monoliths. Inclusion of iron in non-carbonate monoliths resulted in the lowest concrete diffusivity values for both iodine and rhenium. This suggests that in the presence of iron, iodine and rhenium are converted to reduced species, which are less soluble and better retained within the concrete monolith. The release of iodine and rhenium was greatest from iron-bearing, carbonated concrete monoliths, suggesting carbonation negates the effect of iron on the retention of iodine and rhenium within concrete monoliths. This is likely due to enhanced formation of microcracks in the presence of iron, which provide preferential paths for contaminant migration. Although the release of iodine and rhenium were greatest from carbonated concrete monoliths containing iron, the migration of iodine and rhenium within a given half-cell is dependent on the moisture content, soil diffusivity, and diffusing species.

  19. 46 CFR 185.230 - Report of accident to aid to navigation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Report of accident to aid to navigation. 185.230 Section 185.230 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS... aid to navigation. Whenever a vessel collides with a buoy, or other aid to navigation under...

  20. 47 CFR 90.185 - Multiple licensing of radio transmitting equipment in the mobile radio service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Multiple licensing of radio transmitting equipment in the mobile radio service. 90.185 Section 90.185 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES...

  1. 12 CFR 303.185 - Merger transactions involving foreign banks or foreign organizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Merger transactions involving foreign banks or foreign organizations. 303.185 Section 303.185 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION... for obligations which will, after the merger transaction, be treated as deposits under section...

  2. 20 CFR 402.185 - Waiver or reduction of fees in the public interest.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... interest. 402.185 Section 402.185 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF... demonstrate that likelihood, while such a claim by a representative of the news media is better evidence. (4... the requester's commercial interest and, if so, whether this effect outweighs the advancement of...

  3. 20 CFR 402.185 - Waiver or reduction of fees in the public interest.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... interest. 402.185 Section 402.185 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF... demonstrate that likelihood, while such a claim by a representative of the news media is better evidence. (4... the requester's commercial interest and, if so, whether this effect outweighs the advancement of...

  4. 20 CFR 402.185 - Waiver or reduction of fees in the public interest.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... interest. 402.185 Section 402.185 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF... demonstrate that likelihood, while such a claim by a representative of the news media is better evidence. (4... the requester's commercial interest and, if so, whether this effect outweighs the advancement of...

  5. 20 CFR 402.185 - Waiver or reduction of fees in the public interest.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... interest. 402.185 Section 402.185 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF... demonstrate that likelihood, while such a claim by a representative of the news media is better evidence. (4... the requester's commercial interest and, if so, whether this effect outweighs the advancement of...

  6. 20 CFR 402.185 - Waiver or reduction of fees in the public interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... interest. 402.185 Section 402.185 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF... demonstrate that likelihood, while such a claim by a representative of the news media is better evidence. (4... the requester's commercial interest and, if so, whether this effect outweighs the advancement of...

  7. 36 CFR 18.5 - May property be leased without receiving fair market value rent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of the property or terms of the lease that limit the value and/or the highest and best use of the... without receiving fair market value rent? 18.5 Section 18.5 Parks, Forests, and Public Property NATIONAL... leased without receiving fair market value rent? Property may be leased under this part only if the...

  8. 36 CFR 18.5 - May property be leased without receiving fair market value rent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of the property or terms of the lease that limit the value and/or the highest and best use of the... without receiving fair market value rent? 18.5 Section 18.5 Parks, Forests, and Public Property NATIONAL... leased without receiving fair market value rent? Property may be leased under this part only if the...

  9. 36 CFR 18.5 - May property be leased without receiving fair market value rent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of the property or terms of the lease that limit the value and/or the highest and best use of the... without receiving fair market value rent? 18.5 Section 18.5 Parks, Forests, and Public Property NATIONAL... leased without receiving fair market value rent? Property may be leased under this part only if the...

  10. 46 CFR 185.730 - Servicing of inflatable liferafts, inflatable buoyant apparatus, inflatable life jackets, and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... servicing sticker affixed under 46 CFR 160.151-57(n), except that servicing may be delayed until the next... apparatus, inflatable life jackets, and inflated rescue boats. 185.730 Section 185.730 Shipping COAST GUARD... liferafts, inflatable buoyant apparatus, inflatable life jackets, and inflated rescue boats. (a)...

  11. 46 CFR 185.730 - Servicing of inflatable liferafts, inflatable buoyant apparatus, inflatable life jackets, and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... servicing sticker affixed under 46 CFR 160.151-57(n), except that servicing may be delayed until the next... apparatus, inflatable life jackets, and inflated rescue boats. 185.730 Section 185.730 Shipping COAST GUARD... liferafts, inflatable buoyant apparatus, inflatable life jackets, and inflated rescue boats. (a)...

  12. 46 CFR 185.730 - Servicing of inflatable liferafts, inflatable buoyant apparatus, inflatable life jackets, and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... servicing sticker affixed under 46 CFR 160.151-57(n), except that servicing may be delayed until the next... apparatus, inflatable life jackets, and inflated rescue boats. 185.730 Section 185.730 Shipping COAST GUARD... liferafts, inflatable buoyant apparatus, inflatable life jackets, and inflated rescue boats. (a)...

  13. 46 CFR 185.614 - Portable watertight containers for distress flares and smoke signals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... smoke signals. 185.614 Section 185.614 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... watertight containers for distress flares and smoke signals. Portable watertight containers for distress flares and smoke signals shall be of a bright color, and containers shall be clearly marked in...

  14. 46 CFR 185.614 - Portable watertight containers for distress flares and smoke signals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... smoke signals. 185.614 Section 185.614 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... watertight containers for distress flares and smoke signals. Portable watertight containers for distress flares and smoke signals shall be of a bright color, and containers shall be clearly marked in...

  15. 46 CFR 185.614 - Portable watertight containers for distress flares and smoke signals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... smoke signals. 185.614 Section 185.614 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... watertight containers for distress flares and smoke signals. Portable watertight containers for distress flares and smoke signals shall be of a bright color, and containers shall be clearly marked in...

  16. 46 CFR 185.614 - Portable watertight containers for distress flares and smoke signals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... smoke signals. 185.614 Section 185.614 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... watertight containers for distress flares and smoke signals. Portable watertight containers for distress flares and smoke signals shall be of a bright color, and containers shall be clearly marked in...

  17. 46 CFR 185.614 - Portable watertight containers for distress flares and smoke signals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... smoke signals. 185.614 Section 185.614 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... watertight containers for distress flares and smoke signals. Portable watertight containers for distress flares and smoke signals shall be of a bright color, and containers shall be clearly marked in...

  18. 24 CFR 990.185 - Utilities expense level: Incentives for energy conservation/rate reduction.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Utilities expense level: Incentives for energy conservation/rate reduction. 990.185 Section 990.185 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC...

  19. 33 CFR 207.185 - Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and navigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and navigation. 207.185 Section 207.185 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION...

  20. 33 CFR 207.185 - Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and navigation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and navigation. 207.185 Section 207.185 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION...